{
    "srDOamxh": {
        "id": "srDOamxh",
        "title": "Manufacturing Technology Research on Invar Steel Mould",
        "abstract": "Surface of composite parts is no longer processed after curing,so the quality of composite molding is of the important effect to the quality of products' shape and surface.Thermal expansion coefficient of several mould material is tested by using the GB/T4339-1999 standard.The results show that Invar steel match with composite material.The welding and milling properties of an Invar steel is studied.The results show that a good welding joint can be obtained by setting the welding line gap of 2 mm,electric current of 170 A,and protecting gas of 15 L/min.It is also seen that the machine operates smoothly and the milling cutter has not been abraded obviously at the rough machining step by setting the rotate speed of 1 300-1 500 r/min,moving speed of 400 mm/min,and milling depth of 2.5 mm.A good milling surface can be obtained at the finish-machining step by setting the rotate speed of 2 200-2 500 r/min,moving speed of 480 mm/min,and milling depth of 0.5 mm.",
        "keywords": [
            "welding",
            "mould",
            "technology research",
            "milling",
            "Invar steel"
        ],
        "authors": [
            {
                "name": "Huang Ganghua",
                "org": "Institute of Aeronautical Manufacturing Technology.Shanghai Aircraft Manufacturing Corporation.Ltd.,Shanghai ,China"
            },
            {
                "name": "Zhang Dongmei",
                "org": "Institute of Aeronautical Manufacturing Technology.Shanghai Aircraft Manufacturing Corporation.Ltd.,Shanghai ,China"
            },
            {
                "name": "Yan Dongxiu",
                "org": "Institute of Aeronautical Manufacturing Technology.Shanghai Aircraft Manufacturing Corporation.Ltd.,Shanghai ,China"
            },
            {
                "name": "Yang Nihong",
                "org": "Institute of Aeronautical Manufacturing Technology.Shanghai Aircraft Manufacturing Corporation.Ltd.,Shanghai ,China"
            },
            {
                "name": "Liu Weiping",
                "org": "Institute of Aeronautical Manufacturing Technology.Shanghai Aircraft Manufacturing Corporation.Ltd.,Shanghai ,China"
            }
        ],
        "venue": "Advances in Aeronautical Science and Engineering",
        "year": 2011
    },
    "2FRVajBT": {
        "id": "2FRVajBT",
        "title": "Change in preform thickness throughout the vacuum assisted resin infusion process and the post-filling control",
        "abstract": "The non-contact electric eddy current displacement sensor system was applied to real-time monitor the preform thickness change throughout the vacuum assisted resin infusion (VARI) process. The compaction behavior of the preform during the VARI process was discussed. And the effect of the post-filling time on the preform thickness and the fiber volume fraction was studied. The result indicates that the compaction behavior of the preform can be divided into three stages: the preform thickness increases rapidly when the resin is infused; the perform thickness is almost not changed during the post-filling; the preform thickness decreases rapidly and drives to a stable value after that the resin-inlet is clamped. The final part thickness varies with the post-filling time, and the variation tendency is similar to a sinusoid. The fiber volume fraction is the lowest and decreases 1.7% compared with that without post-filling, when the post-filling time is about 10 min. And the fiber volume fraction is the greatest and increases 1.6% compared with that without post-filling, when the post filling time is about 40 min.",
        "keywords": [
            "Composites",
            "Fiber volume fraction",
            "Post-filling control",
            "Preform",
            "Thickness",
            "Vacuum assisted resin infusion (VARI)"
        ],
        "authors": [
            {
                "name": "Lijian Pan",
                "org": "Shanghai Aircraft Manufacturing Co. Ltd.(Shanghai Aircraft Manufacturing Co., Ltd,Shanghai Aircraft Manufacturing Co., Ltd.,Shanghai Aircraft Manufacturing Co. Ltd.),Shanghai,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Shanghai Aircraft Manufacturing Co. Ltd.(Shanghai Aircraft Manufacturing Co., Ltd,Shanghai Aircraft Manufacturing Co., Ltd.,Shanghai Aircraft Manufacturing Co. Ltd.),Shanghai,China"
            },
            {
                "name": "Ping Chen",
                "org": "Shanghai Aircraft Manufacturing Co. Ltd.(Shanghai Aircraft Manufacturing Co., Ltd,Shanghai Aircraft Manufacturing Co., Ltd.,Shanghai Aircraft Manufacturing Co. Ltd.),Shanghai,China"
            },
            {
                "name": "Fangfang Qi",
                "org": "Shanghai Aircraft Manufacturing Co. Ltd.(Shanghai Aircraft Manufacturing Co., Ltd,Shanghai Aircraft Manufacturing Co., Ltd.,Shanghai Aircraft Manufacturing Co. Ltd.),Shanghai,China"
            }
        ],
        "venue": "Fuhe Cailiao Xuebao/Acta Materiae Compositae Sinica",
        "year": 2012
    },
    "apFoZqo6": {
        "id": "apFoZqo6",
        "title": "Tensile behavior and parameters designing of double-sides flush repair of composite laminates",
        "abstract": "The tensile behavior of composite laminate containing penetrated damage and the optimization of repair designing parameters were studied after being flush repaired on double-sides. The results demonstrate that the recovery of failure strength of repairing specimens could reach 80% after double-sided flush repaired. The strength of repair specimens can be recovered to the maximum, when scarf ratio is 1:40, and covering layers number is three with the layer's orientation is the same as the mother plate's layer which is close to covering layers. Double-sides flush repairing is familiar to any thicknesses and any lay-up ways of the mother laminates. A 3D finite element analysis was studied to verify the test result using ABAQUS software. In the model, every layer was set as a section, then give it the orientation of each layer. The analysis data are agree with the test results.",
        "keywords": [
            "Composite laminate",
            "Double-sides flush repair",
            "Finite element modeling",
            "Penetrated damage",
            "Recovery of failure strength",
            "Scarf ratio"
        ],
        "authors": [
            {
                "name": "Xia Guo",
                "org": "Beijing University of Aeronautics and Astronautics(Beijing University of Aeronautics and Astronautics,Beijing Univ. of Aero. and Astron.),Beijing,China"
            },
            {
                "name": "Zhidong Guan",
                "org": "Beijing University of Aeronautics and Astronautics(Beijing University of Aeronautics and Astronautics,Beijing Univ. of Aero. and Astron.),Beijing,China"
            },
            {
                "name": "Sui Liu",
                "org": "Beijing University of Aeronautics and Astronautics(Beijing University of Aeronautics and Astronautics,Beijing Univ. of Aero. and Astron.),Beijing,China"
            },
            {
                "name": "Jia Liu",
                "org": "Commercial Aircraft Corporation of China Ltd(Commercial Aircraft Corporation of China Ltd,Commercial Aircraft Corporation of China, Ltd.,Commercial Aircraft Corporation of China Ltd.,Commercial Aircraft Corporation of China, Ltd),Shanghai,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Commercial Aircraft Corporation of China Ltd(Commercial Aircraft Corporation of China Ltd,Commercial Aircraft Corporation of China, Ltd.,Commercial Aircraft Corporation of China Ltd.,Commercial Aircraft Corporation of China, Ltd),Shanghai,China"
            }
        ],
        "venue": "Fuhe Cailiao Xuebao/Acta Materiae Compositae Sinica",
        "year": 2012
    },
    "zvUcvfNH": {
        "id": "zvUcvfNH",
        "title": "Process parameters effect on the edgewise compressive behavior of repaired honeycomb sandwich structures",
        "abstract": "Three different repair methods were adopted in the paper to restore the mechanical performance of composite honeycomb sandwich panels with different initial damages, and an experimental study was conducted to compare the edgewise compressive capacities of repaired specimens. Test results demonstrate that all these repair methods can recover the edgewise compressive strength of specimens effectively, and the strength recoveries are all above 79% of the intact panel level. In order to analyze experimental results, k-sample Anderson-Darling test was introduced to investigate the influence of process parameters on edgewise compressive strength of repaired specimens. Test results show that middle-temperature cure can hardly affect the edgewise compressive performance of repaired specimens. However, the edgewise compressive strength is higher for specimens cured by autoclave, but the improve extent is influenced by the effective height of the repair region. Besides, unsymmetrical repair structures should be adopted cautiously to avoid the mechanical performance degradation induced by the additional bending moment.",
        "keywords": [
            "Edgewise compressive strength",
            "Honeycomb sandwich structure",
            "k-sample Anderson-Darling test",
            "Process parameter",
            "Scarf repair"
        ],
        "authors": [
            {
                "name": "Sui Liu",
                "org": "Beijing University of Aeronautics and Astronautics(Beijing University of Aeronautics and Astronautics,Beijing Univ. of Aero. and Astron.),Beijing,China"
            },
            {
                "name": "Zhidong Guan",
                "org": "Beijing University of Aeronautics and Astronautics(Beijing University of Aeronautics and Astronautics,Beijing Univ. of Aero. and Astron.),Beijing,China"
            },
            {
                "name": "Xia Guo",
                "org": "Beijing University of Aeronautics and Astronautics(Beijing University of Aeronautics and Astronautics,Beijing Univ. of Aero. and Astron.),Beijing,China"
            },
            {
                "name": "Kai Sun",
                "org": "Shanghai Aircraft Manufacturing Co. Ltd.(Shanghai Aircraft Manufacturing Co., Ltd,Shanghai Aircraft Manufacturing Co., Ltd.,Shanghai Aircraft Manufacturing Co. Ltd.),Shanghai,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Shanghai Aircraft Manufacturing Co. Ltd.(Shanghai Aircraft Manufacturing Co., Ltd,Shanghai Aircraft Manufacturing Co., Ltd.,Shanghai Aircraft Manufacturing Co. Ltd.),Shanghai,China"
            },
            {
                "name": "Jiaoyue Kong",
                "org": "Shanghai Aircraft Manufacturing Co. Ltd.(Shanghai Aircraft Manufacturing Co., Ltd,Shanghai Aircraft Manufacturing Co., Ltd.,Shanghai Aircraft Manufacturing Co. Ltd.),Shanghai,China"
            }
        ],
        "venue": "Fuhe Cailiao Xuebao/Acta Materiae Compositae Sinica",
        "year": 2013
    },
    "S9d98A7W": {
        "id": "S9d98A7W",
        "title": "Influence of the Delamitation Flaw on Compressive Strength of Composite Structure",
        "abstract": "With a carbon fiber reinforced epoxy resin composite structure as an example, this paper studies the influence of the delamitation flaw on the compressive strength. The typical test pieces with preset delamitation flaws and the related test facilities were designed to test the compressive strength. The effects of the location and the size of the delamitation flaw are studied by numerical simulations combined with experiments. It is shown that the position of the delamitation flaw affects the delamitation form of the laminate and the small scale delamitation flaws do not affect the compressive strength. This conclusion is useful for the design and manufacture of the aircraft structures.",
        "keywords": [
            "failure mode",
            "delamitation flaw",
            "flaw design",
            "compressive strength",
            "numerical simulation"
        ],
        "authors": [
            {
                "name": "YE Jinrui",
                "org": " School of Materials Science and Engineering, Beihang University, Beijing , China"
            },
            {
                "name": "LI Jia",
                "org": " School of Materials Science and Engineering, Beihang University, Beijing , China"
            },
            {
                "name": "LIU Weiping",
                "org": " Shanghai Aircraft Manufacturing Co., Ltd., Commercial Aircraft Corporation of China, Ltd., Shanghai , China"
            },
            {
                "name": "ZHANG Boming",
                "org": " School of Materials Science and Engineering, Beihang University, Beijing , China"
            }
        ],
        "venue": "Science & Technology Review",
        "year": 2013
    },
    "ED6TONDy": {
        "id": "ED6TONDy",
        "title": "Lateral Compressive Behavior of Scarf Repaired Honeycomb Sandwich Panels",
        "abstract": "In this paper, three different repair methods to restore the mechanical performance of composite honeycomb sandwich panels with different initial damages are studied, and an experimental study was conducted to compare the lateral compressive capacities of the repaired specimens. Test results demonstrate that all these repair methods can recover the lateral compressive strength of the specimens effectively, and the strength recovery rates are all above 79% as compared with the intact panel. The panel with the smallest initial damage has the highest strength recovery. Besides, the unsymmetrical repair structures should be handled cautiously to avoid the mechanical performance degradation induced by the additional bending moment. Based on the test results, a finite element model is adopted to investigate the lateral compressive behavior of the repaired specimen. The calculated stiffness, the ultimate load and the failure pattern are in good agreement with the test results. The numerical model provides an efficient repair design method for the composite honeycomb sandwich panels.",
        "keywords": [
            "scarf repair",
            "edgewise compressive strength",
            "honeycomb sandwich structure",
            "finite element model"
        ],
        "authors": [
            {
                "name": "LIU Sui",
                "org": " School of Aeronautic Science and Engineering, Beihang University, Beijing , China"
            },
            {
                "name": "GUAN Zhidong",
                "org": " School of Aeronautic Science and Engineering, Beihang University, Beijing , China"
            },
            {
                "name": "GUO Xia",
                "org": " School of Aeronautic Science and Engineering, Beihang University, Beijing , China"
            },
            {
                "name": "YAN Dongxiu",
                "org": " Shanghai Aircraft Manufacturing Co., Ltd., Commercial Aircraft Corporation of China, Ltd., Shanghai , China"
            },
            {
                "name": "LIU Weiping",
                "org": " Shanghai Aircraft Manufacturing Co., Ltd., Commercial Aircraft Corporation of China, Ltd., Shanghai , China"
            },
            {
                "name": "KONG Jiaoyue",
                "org": " Shanghai Aircraft Manufacturing Co., Ltd., Commercial Aircraft Corporation of China, Ltd., Shanghai , China"
            }
        ],
        "venue": "Science & Technology Review",
        "year": 2013
    },
    "BIO81oA8": {
        "id": "BIO81oA8",
        "title": "Clinical Analysis of Cladribine in 18 Heavily Retreated Patients with Indolent B-cell Lymphoma",
        "abstract": "Objective:To analyze the response rate and security of cladribine in heavily retreated patients with indolent B-cell lymphomas.Methods:Clinical records of 18 cases of indolent B-cell lymphomas treated with a cladribine combined with cyclophosphamide (CC) regimen were retrospectively analyzed.Results:Among the 18 patients,9 were diagnosed as grade 1-2 follicular lymphoma. The median age was 54.5 years,with marked male predominance(1.25:1).Up to 88.7%of patients were of clinical stages\u2162to\u2163,16.7%of patients had B symptoms,38.9%of patients were with elevated lactate dehydrogenase.Up to 13 patients completed 2 or more cycles of the CC regimen,5 patients completed only 1 cycle.The response rate was 27.8%,with a complete remission(CR) rate of 16.7%.Myelosuppression was the major toxicity with 33.3%of grades 3 and 4 neutropenia.Conclusion:Cladribine used in the heavily retreated patients of indolent B-cell lymphoma shows good efficacy and is safety.",
        "keywords": [
            "Cladribine",
            "Efficacy",
            "Adverse reactions",
            "Indolent B-cell lymphoma"
        ],
        "authors": [
            {
                "name": "Lingyan PING",
                "org": " Department of Lymphoma,Cancer Hospital and Insitute of Peking University,Key Laboratory of Education Department of Developing Mechanism and Transformation of Malignant Tumor,Beijing ,China"
            },
            {
                "name": "Yuqin SONG",
                "org": " Department of Lymphoma,Cancer Hospital and Insitute of Peking University,Key Laboratory of Education Department of Developing Mechanism and Transformation of Malignant Tumor,Beijing ,China"
            },
            {
                "name": "Wen ZHENG",
                "org": " Department of Lymphoma,Cancer Hospital and Insitute of Peking University,Key Laboratory of Education Department of Developing Mechanism and Transformation of Malignant Tumor,Beijing ,China"
            },
            {
                "name": "Xiaopei WANG",
                "org": " Department of Lymphoma,Cancer Hospital and Insitute of Peking University,Key Laboratory of Education Department of Developing Mechanism and Transformation of Malignant Tumor,Beijing ,China"
            },
            {
                "name": "Meifeng TU",
                "org": " Department of Lymphoma,Cancer Hospital and Insitute of Peking University,Key Laboratory of Education Department of Developing Mechanism and Transformation of Malignant Tumor,Beijing ,China"
            },
            {
                "name": "Zhitao YING",
                "org": " Department of Lymphoma,Cancer Hospital and Insitute of Peking University,Key Laboratory of Education Department of Developing Mechanism and Transformation of Malignant Tumor,Beijing ,China"
            },
            {
                "name": "Weiping LIU",
                "org": " Department of Lymphoma,Cancer Hospital and Insitute of Peking University,Key Laboratory of Education Department of Developing Mechanism and Transformation of Malignant Tumor,Beijing ,China"
            },
            {
                "name": "Lijuan DENG",
                "org": " Department of Lymphoma,Cancer Hospital and Insitute of Peking University,Key Laboratory of Education Department of Developing Mechanism and Transformation of Malignant Tumor,Beijing ,China"
            },
            {
                "name": "Chen ZHANG",
                "org": " Department of Lymphoma,Cancer Hospital and Insitute of Peking University,Key Laboratory of Education Department of Developing Mechanism and Transformation of Malignant Tumor,Beijing ,China"
            },
            {
                "name": "Jun ZHU",
                "org": " Department of Lymphoma,Cancer Hospital and Insitute of Peking University,Key Laboratory of Education Department of Developing Mechanism and Transformation of Malignant Tumor,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Clinical Oncology",
        "year": 2011
    },
    "lYG5MhyK": {
        "id": "lYG5MhyK",
        "title": "Mobile-deployed care management based on standardized ePRO and computer-interpretable guideline engine for Chinese lymphoma patients.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Ling Yan Ping",
                "org": "Peking University Cancer Hospital & Institute, Beijing/China"
            },
            {
                "name": "Yuqin Song",
                "org": "Peking University Cancer Hospital, Beijing, China."
            },
            {
                "name": "Tingting Zhang",
                "org": "Kangmei Pharmaceuticals, Shenzhen, China;"
            },
            {
                "name": "Zhi Tao Ying",
                "org": "Peking University Cancer Hospital & Institute, Beijing/China"
            },
            {
                "name": "Chen Zhang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education); Department of Lymphoma; Peking University Cancer Hospital and Institute; Beijing China"
            },
            {
                "name": "Yan Xie",
                "org": "Peking University Cancer Hospital & Institute, Beijing/China"
            },
            {
                "name": "Weiping Liu",
                "org": "Peking University Cancer Hospital & Institute, Beijing/China"
            },
            {
                "name": "Ningjing Lin",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education); Department of Lymphoma; Peking University Cancer Hospital and Institute; Beijing China"
            },
            {
                "name": "Meifeng Tu",
                "org": "Peking University Cancer Hospital & Institute, Beijing/China"
            },
            {
                "name": "Lijuan Deng",
                "org": "Peking University Cancer Hospital & Institute, Beijing/China"
            },
            {
                "name": "Lingling Hong",
                "org": "Kangmei Pharmaceuticals, Shenzhen, China;"
            },
            {
                "name": "Jun Zhu",
                "org": "Department of Lymphoma, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, China;"
            }
        ],
        "venue": "Journal of Global Oncology",
        "year": 2019
    },
    "5izg4SyD": {
        "id": "5izg4SyD",
        "title": "Safety and adverse event profiling of pegylated L-asparaginase combined chemotherapy in the treatment of lymphoma]",
        "abstract": "To analyze the safety and adverse event profiling of pegylated L-asparaginase (PEG-asp) combined chemotherapy in the treatment of lymphoma patients.The clinical data of 32 lymphoma patients on PEG-asp-based chemotherapy from January 2008 to March 2012 were retrospectively collected and analyzed.There were 22 males and 10 females with a median age of 40 years. They were diagnosed as NK/T cell lymphoma (n = 22) and lymphoblastic lymphoma (n = 10). The overall response rate was 71.9% (23/32). And complete remission was 40.6% (13/32) and partial remission 31.3% (10/32). Myelosuppression was the most common adverse event at an incidence of 81.2% (26/32). Other adverse events included a low level of fibrinogen (n = 13, 40.6%), hypoalbuminemia (n = 8, 25%) and hyperlipidemia (n = 9, 28.1%). No instance of anaphylaxis, acute pancreatitis and thrombosis occurred.PEG-asp is both effective and safe in the treatment of lymphoma and it is well-tolerated.",
        "keywords": [
            "anaphylaxis",
            "pegylated l-asparaginase",
            "drug toxicity",
            "asparaginase",
            "lymphoma"
        ],
        "authors": [
            {
                "name": "Ling-yan Ping",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Wen Zheng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Xiao-pei Wang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Yan Xie",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Ning-jing Lin",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Mei-feng Tu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Zhi-tao Ying",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Chen Zhang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Wei-ping Liu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Li-juan Deng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Jun Zhu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Yu-qin Song",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            }
        ],
        "venue": "Zhonghua yi xue za zhi",
        "year": 2012
    },
    "RjRE7ksv": {
        "id": "RjRE7ksv",
        "title": "Burden of lymphoma in China, 2006-2016: an analysis of the Global Burden of Disease Study 2016.",
        "abstract": "The burden of lymphoma in China showed unexpected patterns varied by sex, age, and provinces, with an increased trend of NHL and a decreased trend of HL from 2006 to 2016.",
        "keywords": [
            "Epidemiology",
            "Hodgkin\u2019s disease",
            "Incidence",
            "Lymphoma",
            "Mortality",
            "Non-Hodgkin",
            "Prevalence"
        ],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China."
            },
            {
                "name": "Jiangmei Liu",
                "org": "National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China."
            },
            {
                "name": "Yuqin Song",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China."
            },
            {
                "name": "Xinying Zeng",
                "org": "National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China."
            },
            {
                "name": "Xiaopei Wang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China."
            },
            {
                "name": "Lan Mi",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China."
            },
            {
                "name": "Cai Cai",
                "org": "Beijing Institute of Survey and Mapping, Beijing Municipal Key Laboratory of Urban Spatial Information Engineering, Beijing, China."
            },
            {
                "name": "Lijun Wang",
                "org": "National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. wanglijun@ncncd.chinacdc.cn."
            },
            {
                "name": "Jun Ma",
                "org": "Department of Hematology & Oncology, Harbin Institute of Hematology & Oncology, Harbin, China. majun0322@126.com."
            },
            {
                "name": "Jun Zhu",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China. zhu-jun2017@outlook.com."
            }
        ],
        "venue": "Journal of hematology & oncology",
        "year": 2019
    },
    "OXgjB1hy": {
        "id": "OXgjB1hy",
        "title": "Primary breast lymphoma: Clinical analysis of 32 cases",
        "abstract": "Objective: To investigate the clinical features and the prognosis of patients with primary breast diffuse large B cell lymphoma. Methods: The clinical features and prognostic factors of 32 patinets who were newly diagnosed as primary breast diffuse large B cell lymphoma in Peking University Cancer Hospital from January 2005 to December 2012 were retrospectively analyzed. Results: The median age of the 32 patients was 51 years (range: 23 to 85). Among all patients, 13 patients were Ann Arbor stage, 15 patients were stage, and 4 patients were stage ?. Only 3 patients presented with B symptoms, 4 patients had bilateral involvement, 10 patients had elevated LDH (lactate dehydrogenase) at diagnosis; 25 patients had IPI (International Prognostic Index) score 0-1 (low risk), 3 (low/intermediate risk) had score 2, 3 (high/intermediate risk) had score 3, 1 (high risk) had score 1. Five patients received radiotherapy after chemotherapy, 16 patients received CNS (central nervous system) prophylaxis during the treatment. Immunochemical examination was performed in 17 patients, 16 belonged to non-germinal center B cell-like subgroup. First-line chemotherapy regimens were R-CHOP and CHOP-like-based regimens. Complete response was achieved in 90.6% of the patients. The median follow-up period was 35 months (range: 2 to 106). The 1-year, 2- year, and 5-year survival rates were 85%, 77%, and 46%, respectively. Statistical analysis revealed that Ann Arbor stage (P = 0.004), IPI (P = 0.005), LDH level (P = 0.008) as well as erythrocyte sedimentation rate (P = 0.02) were prognostic factors of survival, and IPI was an independent prognostic factor. Conclusion: The prognosis of primary breast diffuse large B cell lymphoma is usually poor. S IPI was an independent prognostic factor of survival. Copyright \u00a9 2013 by TUMOR.",
        "keywords": [
            "Breast",
            "Clinical characteristics",
            "Diffuse large B cell lymphoma",
            "Prognosis"
        ],
        "authors": [
            {
                "name": "Chen Zhang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "WANG Xiao-pei",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "YING Zhi-tao",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Wen Zheng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Yan Xie",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "LIN Ning-jing",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Ping Ling-yan",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "DENG Li-juan",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "SONG Yu-qin",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Jun Zhu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            }
        ],
        "venue": "Tumor",
        "year": 2013
    },
    "S1Q5G6AS": {
        "id": "S1Q5G6AS",
        "title": "Clinical analysis of 69 patients with primary gastric diffuse large B-cell lymphoma",
        "abstract": "Objective: To analyze the diagnosis, treatment and prognosis of primary gastric diffuse large B-cell lymphoma (PGDLBCL). Methods: Retrospective analysis was conducted in 69 cases of PGDLBCL between January 2007 and December 2009.The data of clinical presentations, diagnosis, treatment and prognosis were collected, and the association of clinicopathological features with treatment outcomes and prognosis was analyzed. Results: PGDLBCL comprised about 10.44% (69/661) of all lymphomas, including 29 males and 40 females; the median age was 54 years old (range: 21-78). The major clinical presentations of PGDLBCL were abdominal pain, abdominal distension and melena. ALL patients were treated with chemotherapy-based comprehensive treatment. In this cohort, the complete remission rate was 37.7% (26/69), the partial remission rate was 46.4% (32/69), and the overall response rate was 81.4% (58/69). The univariate analysis revealed that the patients with increased level of serum lactate dehydrogenase (LDH) had poor response (P<0.05). The one-, two- and three-year survival rates were 89.2%, 84.2% and 81.3%%, respectively. The univariate analysis revealed that the age, international prognostic index (IPI) and serum LDH had significant effects on the prognosis; COX regression multivariate analysis showed that only serum LDH had significant effect on the prognosis. Conclusion: PGDLBCL is more common in female and treated mainly with chemotherapy-based comprehensive treatment. The prevention and treatment of gastrointestinal bleeding and perforation should be emphasized. Serum LDH was an important prognostic factor for PGDLBCL. Copyright\u00a9 2011 by TUMOR.",
        "keywords": [
            "Diagnosis",
            "Lymphoma",
            " large B-cell",
            " diffuse",
            "Prognosis",
            "Stomach",
            "Therapy"
        ],
        "authors": [
            {
                "name": "WANG Xiao-pei",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Wen Zheng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Yan Xie",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "TU Mei-feng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "LIN Ning-jing",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "SONG Yu-qin",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "PING Ling-yan",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "YING Zhi-tao",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "DENG Li-juan",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Chen Zhang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Jun Zhu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            }
        ],
        "venue": "Tumor",
        "year": 2011
    },
    "3jtTyeOj": {
        "id": "3jtTyeOj",
        "title": "Phase I study of anti-CD52 monoclonal antibody as treatment for patients with relapsed or refractory chronic lymphocytic leukemia and peripheral T cell lymphoma",
        "abstract": "Objective: The relapsed or refractory chronic lymphocytic leukemia (CLL) and peripheral T-cell lymphomas (PTCLs) respond less well to chemotherapy and generally poor outcome. This phase I study evaluate safety and efficacy of a humanized anti-CD52 monoclonal antibody (anti-CD52 mAb) in the treatment of patients with CLL and PTCLs. Methods: According to WHO standards, 30 consecutive patients (6 patients with CLL and 24 patients with PTCLs) entered the study from November 2007 to June 2010. Anti-CD52 mAb was diluted in 100 mL of 0.9% normal saline and administered by intravenous infusion. Anti-CD52 mAb is divided into three dose groups, a single 3 mg group of 10 cases, a single 10 mg group of 12 cases, and the 30 mg group of 8 cases. The usage of 30 mg group is as follows, The first dose was 3 mg on day 1, which was increased to 10 mg on day 3 and then to 30 mg on day 5 as soon as infusion-related reactions were tolerated. The 30-mg dose was subsequently administered 3 times a week for up to 7 weeks. The 30 mg group is the same as foreign literature and medicine instructions. The Clinical data of the patients were analyzed by statistic software package of SPSS 16.0. Results: There were 17 males and 13 females, the median age was 47 (21~69 years) in the cohort. All patients were relapsed or refractory cases. Of the 30 patients, 26 (86.7%) developed adverse reactions. There were 59 adverse events in 26 patients. The most frequent side effects were Hematologic toxicity, grade 3/4 neutropenia was observed in 6 of 59 (10.2%), but no severe thrombocytopenia. One presented a grade 3 liver enzyme elevation. Infectious complications were by far the most frequent nonhematologic toxicities. Grade 3/4 infection were in 7 of 59 (11.9%), including Cytomegalovirus infection in 4 of 59 and Bacterial infectious complication in 3 of 59. The Bacterial infectious complications were treated successfully with vancomycin and ceftriaxone. The overall response rate of anti-CD52 mAb was 46.7% (14/30) with 6.7% (2/30) complete remission rate (CR) and 40.0% (12/30) partial remission rate (PR). Conclusion: Anti-CD52 mAb is a practicable and effective regimen for patients with CLL and PTCL.",
        "keywords": [
            "Adverse reactions",
            "Anti-CD52 monoclonal antibody",
            "Chronic lymphocytic leukemia",
            "Peripheral T-cell lymphomas",
            "Treatment"
        ],
        "authors": [
            {
                "name": "Wen Zheng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "FU Zhi-ying",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "TU Mei-feng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "LIN Ning-jing",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Yan Xie",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "WANG Xiao-pei",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "SONG Yu-qin",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "PING Ling-yan",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "YING Zhi-tao",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "DENG Li-juan",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Chen Zhang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Jun Zhu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            }
        ],
        "venue": "Chinese Journal of New Drugs",
        "year": 2012
    },
    "LmDmZI1S": {
        "id": "LmDmZI1S",
        "title": "A PHASE I STUDY OF CHIMERIC ANTIGEN RECEPTORMODIFIED T CELLS DIRECTED AGAINST CD19 IN PATIENTS WITH RELAPSED OR REFRACTORYCD19(+) B CELL LYMPHOMAS: INTERIM ANALYSIS",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Zhitao Ying",
                "org": ""
            },
            {
                "name": "X. Xiang",
                "org": ""
            },
            {
                "name": "Yuqin Song",
                "org": ""
            },
            {
                "name": "N. Ding",
                "org": ""
            },
            {
                "name": "Y. Lin",
                "org": ""
            },
            {
                "name": "Wen Zheng",
                "org": ""
            },
            {
                "name": "Xiaopei Wang",
                "org": ""
            },
            {
                "name": "Ningjing Lin",
                "org": ""
            },
            {
                "name": "Meifeng Tu",
                "org": ""
            },
            {
                "name": "Yan Xie",
                "org": ""
            },
            {
                "name": "Chen Zhang",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Lijuan Deng",
                "org": ""
            },
            {
                "name": "Y. Liu",
                "org": ""
            },
            {
                "name": "Y. Yue",
                "org": ""
            },
            {
                "name": "X. Yu",
                "org": ""
            },
            {
                "name": "H. Liu",
                "org": ""
            },
            {
                "name": "P. Duan",
                "org": ""
            },
            {
                "name": "F. Chen",
                "org": ""
            },
            {
                "name": "X. Wu",
                "org": ""
            },
            {
                "name": "X.F. Huang",
                "org": ""
            },
            {
                "name": "L. Jones",
                "org": ""
            },
            {
                "name": "X. Kang",
                "org": ""
            },
            {
                "name": "S. Chen",
                "org": ""
            },
            {
                "name": "Jun Zhu",
                "org": ""
            }
        ],
        "venue": "Hematological Oncology",
        "year": 2017
    },
    "ohtX3HRM": {
        "id": "ohtX3HRM",
        "title": "Clinical analysis of primary systemic anaplastic large cell lymphoma: A report of 45 cases",
        "abstract": "Objective: To investigate the clinical characteristics and prognosis of patients with primary systemic ALCL (anaplastic large cell lymphoma), and to explore the role of ALK (anaplastic lymphoma kinase) and other prognostic factors in primary systemic ALCL. Methods: Clinical data and follow-up information of 45 primary systemic ALCL patients treated in Peking University Cancer Hosipital from December 2002 to September 2011 were reviewed. Results: Among the 45 patients with primary systemic ALCL, 34 (75.6%) were ALK-positive, and 11 (24.4%) were ALK-negative. The only different clinical characteristic with statistical significance in these patients between ALK (+) and ALK (-) was age, with a younger median age of 23.5 years for ALK (+) compared with 49.0 years for ALK (-) (P = 0.022). Median follow-up period was 32 months. Of 45 patients, the 5-year estimated survival rate was 71.9%. The 5-year estimated survival rates were 71% and 72% in patients with ALK (+) and ALK (-), respectively (P = 0.581). Univariate and multivariate analyses showed that only short-term response was associated with survival rate (P < 0.05). Conclusion: Primary systemic ALCL usually occurs in young patients, with a good prognosis. ALK expression alone is not sufficient to determine the outcome of ALCL. This study suggests that short-term response is an independent prognostic factor. Copyright \u00a9 2013 by TUMOR.",
        "keywords": [
            "Anaplastic large cell lymphoma primary systemic",
            "Anaplastic lymphoma kinase",
            "Drug therapy",
            "Non-Hodgkin's Lymphoma",
            "Prognosis"
        ],
        "authors": [
            {
                "name": "Yan Xie",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Wen Zheng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "WANG Xiao-pei",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "LIN Ning-jing",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "TU Mei-feng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Ping Ling-yan",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "YING Zhi-tao",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Chen Zhang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "DENG Li-juan",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "SONG Yu-qin",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Jun Zhu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            }
        ],
        "venue": "Tumor",
        "year": 2013
    },
    "4wGoNk1r": {
        "id": "4wGoNk1r",
        "title": "Combination of Enzastaurin and Ibrutinib synergistically induces anti-tumor effects in diffuse large B cell lymphoma.",
        "abstract": "Combination of enzastaurin and ibrutinib had synergistic anti-tumor effects in DLBCL, independent of molecular subtype. These results provided a sound foundation for an attractive therapeutic treatment, and the simultaneous suppression of BTK and PKC\u03b2 might be a new treatment strategy for DLBCL.",
        "keywords": [
            "BTK inhibitor",
            "Diffuse large B cell lymphoma",
            "Drug combination",
            "PKC\u03b2 inhibitor",
            "Targeted therapy"
        ],
        "authors": [
            {
                "name": "Yizi He",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of lymphoma, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, People's Republic of China."
            },
            {
                "name": "Jiao Li",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of lymphoma, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, People's Republic of China."
            },
            {
                "name": "Ning Ding",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of lymphoma, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, People's Republic of China."
            },
            {
                "name": "Xiaogan Wang",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of lymphoma, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, People's Republic of China."
            },
            {
                "name": "Lijuan Deng",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of lymphoma, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, People's Republic of China."
            },
            {
                "name": "Yan Xie",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of lymphoma, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, People's Republic of China."
            },
            {
                "name": "Zhitao Ying",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of lymphoma, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, People's Republic of China."
            },
            {
                "name": "Weiping Liu",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of lymphoma, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, People's Republic of China."
            },
            {
                "name": "Lingyan Ping",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of lymphoma, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, People's Republic of China."
            },
            {
                "name": "Chen Zhang",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of lymphoma, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, People's Republic of China."
            },
            {
                "name": "Yuqin Song",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of lymphoma, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, People's Republic of China. songyuqin622@163.com."
            },
            {
                "name": "Jun Zhu",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of lymphoma, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, People's Republic of China. zhu-jun2017@outlook.com."
            }
        ],
        "venue": "Journal of experimental & clinical cancer research : CR",
        "year": 2019
    },
    "y4Dl6Ml5": {
        "id": "y4Dl6Ml5",
        "title": "Mortality of lymphoma and myeloma in China, 2004-2017: an observational study.",
        "abstract": "The mortality of lymphoma and myeloma increased in China from 2004 to 2017. The rapid increase in disease burden in rural areas highlights new challenges for disease prevention and control strategies.",
        "keywords": [
            "Epidemiology",
            "Lymphoma",
            "Mortality",
            "Multiple myeloma"
        ],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital and Institute, Beijing, China."
            },
            {
                "name": "Jiangmei Liu",
                "org": "National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China."
            },
            {
                "name": "Yuqin Song",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital and Institute, Beijing, China."
            },
            {
                "name": "Xiaopei Wang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital and Institute, Beijing, China."
            },
            {
                "name": "Maigeng Zhou",
                "org": "National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China."
            },
            {
                "name": "Lijun Wang",
                "org": "National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. wanglijun@ncncd.chinacdc.cn."
            },
            {
                "name": "Jun Ma",
                "org": "Harbin Institute of Hematology and Oncology, Harbin, China. majun0322@126.com."
            },
            {
                "name": "Jun Zhu",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital and Institute, Beijing, China. zhu-jun2017@outlook.com."
            }
        ],
        "venue": "Journal of hematology & oncology",
        "year": 2019
    },
    "pupqAvBl": {
        "id": "pupqAvBl",
        "title": "Prognostic value of interim18F-FDG PET/CT in diffuse large B-cell lymphoma",
        "abstract": "Objective: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease. The prognostic factor currently used is not accurate enough to predict the outcomes of patients with DLBCL. The prognostic significance of interim PET/CT in DLBCL remains controversial. The aim of this study is to determine the predictive value of interim 18F-FDG PET/CT after first-line treatment in patients with DLBCL. Methods: Thirty-two patients with DLBCL underwent baseline, interim and post-treatment 18F-FDG PET/CT scans. Imaging results were analyzed for the survival of patients via software SPSS 13.0, retrospectively. Results: Thirty-one of the 32 patients were treated with R-CHOP regimen, and interim 18F-FDG PET/CT of 24 patients was performed after 2 cycles of treatment. After a median follow-up period of 16.7 months, the 2-year progression-free survival (PFS) rates were significantly different between the groups above and below SUVmax cut-off value of 2.5 (P=0.039). No significant differences were found in the 2-year PFS rates if SUVmax cut-off values were set as 2.0 and 3.0, respectively (P=0.360; P=0.113). Conclusions: Interim PET/CT could predict the prognosis of DLBCL patients with the SUVmax cut-off value of 2.5, but more clinical data should be concluded to confirm this conclusion. \u00a9 Chinese Journal of Cancer Research. All rights reserved.",
        "keywords": [
            "Diffuse",
            "Fludeoxyglucose F18",
            "Large cell",
            "Lymphoma",
            "Prognosis",
            "Standard utility value"
        ],
        "authors": [
            {
                "name": "Zhitao Ying",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Xuejuan Wang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Yuqin Song",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Wen Zheng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Xiaopei Wang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Yan Xie",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Ningjing Lin",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Meifeng Tu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Lingyan Ping",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Lijuan Deng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Chen Zhang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Zhi Yang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Jun Zhu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            }
        ],
        "venue": "Chinese Journal of Cancer Research",
        "year": 2013
    },
    "GlDQ2JC4": {
        "id": "GlDQ2JC4",
        "title": "Central nervous system lymphoma and its significance]",
        "abstract": "To explore the clinical features, diagnosis, treatment and prognosis of central nervous system lymphoma (CNSL).Retrospective analysis was conducted for 31 CNSL cases from January 2007 to December 2009 in our hospital. Their clinical data were analyzed by statistical software package SPSS 16.0.Accounting for around 4.7% of all lymphomas at our institution, the present cohort had 21 males and 10 females with a median age of 38 years old. The major clinical manifestations were focal neurological deficits associated with the site of disease or increased intracranial pressure. Most patients were treated with chemotherapy-based regimens. The overall response rate was 67.7% (21/31) with 32.3% (10/31) complete remission rate (CR) and 35.5% (11/31) partial remission rate (PR). Involvement outside CNS or bone marrow, high international prognostic index (IPI) and B symptoms had significant effects on the therapeutic efficacy (P < 0.05). The overall survival rates were 80.7%, 74.2%, 64.5% and 58.1% at 3, 6, 12, 24 months respectively. The median survival time was 22.5 months. Univariate analysis showed that the clinical efficacy had significant effects on the overall survival of patients (OR = 0.030, 95%CI: 0.003 - 0.270, P = 0.000).The prognosis of CNSL remains poor. New diagnostic tools and treatment modality need to be explored.",
        "keywords": [
            "central nervous system neoplasms",
            "diagnosis",
            "lymphoma",
            "therapy"
        ],
        "authors": [
            {
                "name": "Wen Zheng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Ning-jing Lin",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Yan Xie",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Xiao-pei Wang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Mei-feng Tu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Wei-ping Liu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Yu-qin Song",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Ling-yan Ping",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Zhi-tao Ying",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Li-juan Deng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Chen Zhang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Jun Zhu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            }
        ],
        "venue": "Zhonghua yi xue za zhi",
        "year": 2011
    },
    "Kmitqvyp": {
        "id": "Kmitqvyp",
        "title": "PEG-asparaginase in BFM-90 regimen improves outcomes in adults with newly diagnosed lymphoblastic lymphoma.",
        "abstract": "Our clinical data and observed outcomes indicate that 1 dose of PEG-ASP can replace multiple doses of native L-ASP in BFM-90, with predominantly grade 3-4 neutropenia for adult LBL, and no therapy-related deaths. The effect is similar to previous reports of PEG-ASP-containing regimens for adult ALL. Major advantages include less serious allergic reactions, 2-3 weeks of action duration, and convenience for patients and physicians.",
        "keywords": [
            "PEG-asparaginase",
            "lymphoblastic lymphoma",
            "treatment"
        ],
        "authors": [
            {
                "name": "Wen Zheng",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Hanyun Ren",
                "org": "Department of Hematology, Peking University First Hospital, Beijing 100034, China."
            },
            {
                "name": "Xiaoyan Ke",
                "org": "Department of Hematology, Peking University Third Hospital, Beijing 100191, China."
            },
            {
                "name": "Mei Xue",
                "org": "Department of Hematology, Air Force General Hospital of Chinese People's Liberation Army, Beijing 100142, China."
            },
            {
                "name": "Yongqing Zhang",
                "org": "Department of Hematology, the 309th Hospital of Chinese People's Liberation Army, Beijing 100091, China."
            },
            {
                "name": "Yan Xie",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Ningjing Lin",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Meifeng Tu",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Weiping Liu",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Lingyan Ping",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Zhitao Ying",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Chen Zhang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Lijuan Deng",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Xiaopei Wang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Yuqin Song",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Jun Zhu",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            }
        ],
        "venue": "Chinese journal of cancer research = Chung-kuo yen cheng yen chiu",
        "year": 2017
    },
    "MSL1iVp7": {
        "id": "MSL1iVp7",
        "title": "Angioimmunoblastic T cell lymphoma: clinical analysis of 42 cases]",
        "abstract": "To explore the clinical characteristics and prognosis of patients with angioimmunoblastic T cell lymphoma (AITL).The clinical features and prognostic factors of 42 cases newly diagnosed as AITL at Peking University Cancer Hospital from January 2007 to August 2012 were retrospectively analyzed.Their median age was 59(34-76) years. Among them, 97.6% cases (41/42) belonged to Ann Arbor stage III/IV, 73.8% (31/42) cases presented with B symptoms, 85.7% (36/42)cases had painless lymphadenopathy, 52.4% (22/42)cases extranodal involvement, 64.3% (27/42) cases elevated lactate dehydrogenase and 45.2% (19/42) cases elevated \u03b22-microglobulin at diagnosis. And 40.5% (17/42) cases had 3 points of international prognostic index (IPI) score with the highest proportion.First-line chemotherapy was predominantly CHOP (cyclophosphamide, vincristine, doxorubicin, prednisolone) or CHOP-like-based and complete response was achieved in 44.7% (17/38) of them. The median follow-up time was 40 (2-106) months The 1, 2, 5-year survival rates were 78%, 57% and 39% respectively.Statistical analysis showed that IPI was an independent prognostic factor (P = 0.009).Other factors included gender (P = 0.311), age (P = 0.263), with or without B symptoms (P = 0.102), Ki-67 index (P = 0.146) as well as the choice of first-line chemotherapy (P = 0.292) each had a tendency of affecting; the survival rate, but failed to reach statistical significance.Angioimmunoblastic T-cell lymphoma is a major type of peripheral T-cell lymphoma. Most AITL patients are elders with a late stage. The disease generally displays an aggressive clinical course and poor prognosis.",
        "keywords": [
            "angioimmunoblastic t cell lymphoma",
            "clinical characteristics",
            "lymphoma",
            "prognosis"
        ],
        "authors": [
            {
                "name": "Chen Zhang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Xiao-pei Wang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Wen Zheng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Yan Xie",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Ning-jing Lin",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Ling-yan Ping",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Zhi-tao Ying",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Wei-ping Liu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Li-juan Deng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Yu-qin Song",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Jun Zhu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            }
        ],
        "venue": "Zhonghua yi xue za zhi",
        "year": 2013
    },
    "x22jjvB0": {
        "id": "x22jjvB0",
        "title": "Prognostic value of maximum standard uptake on pretreatment 18F-FDG PET/CT scan in newly diagnosed diffuse large B cell lymphoma]",
        "abstract": "To evaluate the prognostic value of maximum standard uptake (SUVmax) on pretreatment (18)F-fluoro-2-deoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) scan in patients with newly diagnosed diffuse large B cell lymphoma (DLBCL).The clinical data of 39 DLBCL patients undergoing a PET/CT scan at pre-treatment from December 2009 to October 2011 were analyzed retrospectively. SUVmax on PET/CT was evaluated by SPSS 13.0 for the associations with patient characteristics, prognostic factors, treatment efficacy and survival time.The median SUVmax was higher in non-germinal center B cell-like (non-GCB) patients than that in GCB ones (18.0(2.2 - 40.5) vs 11.6 (5.3 - 18.7), P = 0.039). No difference of SUVmax was observed between the patients with and without bulky disease (P = 0.539). SUVmax was not associated with such patient characteristics as international protein index, age, stage, Eastern Cooperative Oncology Group performance status, lactate dehydrogenase, number of extranodal involvement and Ki-67 (all P > 0.05). No significant difference in median SUVmax existed between complete remission (CR) and non-CR patients (P = 0.312). The difference of SUVmax was insignificant for the patients with efficacy and no efficacy (P = 0.243). With the cut-off values of 10, 15, 20, the CR rate, response rate, 2-year progression-free survival (PFS) rate and 2-year overall survival (OS) rate were not different between the patients with SUVmax below and above cut-off value (all P > 0.05).The prognostic value of SUVmax on PET/CT is indeterminate. And it can not be used to predict the patient prognosis.",
        "keywords": [
            "prognosis",
            "diffuse",
            "standard utility value",
            "fludeoxyglucose f18",
            "large b-cell",
            "lymphoma"
        ],
        "authors": [
            {
                "name": "Zhi-tao Ying",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Xue-juan Wang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Yu-qin Song",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Wen Zheng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Xiao-pei Wang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Yan Xie",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Ning-jing Lin",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Mei-feng Tu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Ling-yan Ping",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Wei-Ping Liu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Li-juan Deng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Chen Zhang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Zhi Yang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Jun Zhu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            }
        ],
        "venue": "Zhonghua yi xue za zhi",
        "year": 2012
    },
    "xurVogKn": {
        "id": "xurVogKn",
        "title": "Clinical characteristics and prognostic factors of primary extranodal classical Hodgkin lymphoma: a retrospective study.",
        "abstract": "The prognosis of PE-cHL is unfavorable. Elevated LDH and PLT are poor prognostic factors for PE-cHL.",
        "keywords": [
            "Hodgkin lymphoma",
            "clinical characteristics",
            "overall survival",
            "primary extranodal",
            "prognostic factors",
            "progression-free survival"
        ],
        "authors": [
            {
                "name": "Mingzi Yang",
                "org": "a Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma , Peking University Cancer Hospital & Institute , Beijing , People's Republic of China."
            },
            {
                "name": "Lingyan Ping",
                "org": "a Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma , Peking University Cancer Hospital & Institute , Beijing , People's Republic of China."
            },
            {
                "name": "Weiping Liu",
                "org": "a Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma , Peking University Cancer Hospital & Institute , Beijing , People's Republic of China."
            },
            {
                "name": "Yan Xie",
                "org": "a Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma , Peking University Cancer Hospital & Institute , Beijing , People's Republic of China."
            },
            {
                "name": "Aliya",
                "org": "a Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma , Peking University Cancer Hospital & Institute , Beijing , People's Republic of China."
            },
            {
                "name": "Yanfei Liu",
                "org": "a Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma , Peking University Cancer Hospital & Institute , Beijing , People's Republic of China."
            },
            {
                "name": "Reyizha Nuersulitan",
                "org": "a Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma , Peking University Cancer Hospital & Institute , Beijing , People's Republic of China."
            },
            {
                "name": "Jun Zhu",
                "org": "a Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma , Peking University Cancer Hospital & Institute , Beijing , People's Republic of China."
            },
            {
                "name": "Meng Wu",
                "org": "a Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma , Peking University Cancer Hospital & Institute , Beijing , People's Republic of China."
            },
            {
                "name": "Yuqin Song",
                "org": "a Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma , Peking University Cancer Hospital & Institute , Beijing , People's Republic of China."
            }
        ],
        "venue": "Hematology (Amsterdam, Netherlands)",
        "year": 2019
    },
    "Jvrvbc2x": {
        "id": "Jvrvbc2x",
        "title": "Prognostic value of pre- and post-transplantation 18 F-fluorodeoxyglucose positron emission tomography results in non-Hodgkin lymphoma patients receiving autologous stem cell transplantation.",
        "abstract": "Post-ASCT PET result was more important than pre-ASCT PET result in predicting outcomes for NHL patients who underwent ASCT. The prognostic significance can be improved when combining pre-ASCT PET result with post-ASCT PET result. Deauville criteria can be used for interpreting PET scans in this scenario.",
        "keywords": [
            "18F-fluorodeoxyglucose",
            "autologous stem cell transplantation",
            "computed tomography",
            "high-dose chemotherapy",
            "non-Hodgkin lymphoma",
            "positron emission tomography"
        ],
        "authors": [
            {
                "name": "Zhitao Ying",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Lan Mi",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Xuejuan Wang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Yuewei Zhang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Zhi Yang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Yuqin Song",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Xiaopei Wang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Wen Zheng",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Ningjing Lin",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Meifeng Tu",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Yan Xie",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Lingyan Ping",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Chen Zhang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Weiping Liu",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Lijuan Deng",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Jun Zhu",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            }
        ],
        "venue": "Chinese journal of cancer research = Chung-kuo yen cheng yen chiu",
        "year": 2017
    },
    "oj886mL5": {
        "id": "oj886mL5",
        "title": "Parallel comparison of 4-1BB or CD28 co-stimulated CD19-targeted chimeric antigen receptor-T cells for B-cell non-Hodgkin lymphoma",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Zhitao Ying",
                "org": "Department of Lymphoma, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, China"
            },
            {
                "name": "Ting He",
                "org": "Immunochina Pharmaceuticals Co., Ltd., Beijing, China"
            },
            {
                "name": "Xiaopei Wang",
                "org": "Department of Lymphoma, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, China"
            },
            {
                "name": "Wen Zheng",
                "org": "Department of Lymphoma, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, China"
            },
            {
                "name": "Ningjing Lin",
                "org": "Department of Lymphoma, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, China"
            },
            {
                "name": "Meifeng Tu",
                "org": "Department of Lymphoma, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, China"
            },
            {
                "name": "Yan Xie",
                "org": "Department of Lymphoma, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, China"
            },
            {
                "name": "Lingyan Ping",
                "org": "Department of Lymphoma, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, China"
            },
            {
                "name": "Chen Zhang",
                "org": "Department of Lymphoma, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, China"
            },
            {
                "name": "Weiping Liu",
                "org": "Department of Lymphoma, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, China"
            },
            {
                "name": "Lijuan Deng",
                "org": "Department of Lymphoma, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, China"
            },
            {
                "name": "Feifei Qi",
                "org": "Immunochina Pharmaceuticals Co., Ltd., Beijing, China"
            },
            {
                "name": "Yanping Ding",
                "org": "Immunochina Pharmaceuticals Co., Ltd., Beijing, China"
            },
            {
                "name": "Xin-an Lu",
                "org": "Immunochina Pharmaceuticals Co., Ltd., Beijing, China"
            },
            {
                "name": "Yuqin Song",
                "org": "Department of Lymphoma, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, China"
            },
            {
                "name": "Jun Zhu",
                "org": "Department of Lymphoma, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing, China"
            }
        ],
        "venue": "Molecular Therapy - Oncolytics",
        "year": 2019
    },
    "1VHvri6N": {
        "id": "1VHvri6N",
        "title": "Efficacy of fludarabine-based combination chemotherapy in 20 patients undergoing initial treatment of marginal zone B-cell lymphoma",
        "abstract": "Objective: To evaluate the efficacy and safety of fludarabine-based combination chemotherapy in 20 patients undergoing initial treatment for marginal zone B-cell lymphoma (MZL). Methods: Data of 20 patients with initial treatment of MZL in the study hospital between September 2005 and February 2010, including 16 with extranodal MZL, 3 with nodal MZL and 1 with splenic MZL, were reviewed in this study. A fludarabine-based regimen was administered in all patients. Specifically, 14 patients were treated with a FC regimen (Fludarabine and cyclophosphamide) while 6 were treated with R-FC (Rituximab + FC). On average the patients received 4.3 (1-6) therapeutic cycles. Results: Eighteen of the 20 patients (90 %) achieved complete remission (CR) and the other 2 patients (10 %) achieved partial remission (PR). The total effective rate (CR + PR) was 100 % (20/20). In all 20 patients, the 1- and 2-year overall survival rates were 88 %, the progression-free survival (PFS) rate was 88 % and the disease-free survival rate was 85 %. Myelosuppression and mild GI toxicity were the major side effects. The rates of leucopenia, nausea and vomiting and mild liver injury were 51 % (III+IV 9.3 %), 20%, and 8%, respectively. Six patients (30 %) had thrombocytopenia; the incidence of thrombocytopenia was 66.7% (4/6) in patients over 60 years old and 14.3% (2/14) in patients younger than 60 years old (P = 0.037). Pulmonary fungal infection occurred in 1 patient (5 %). Conclusion: The fludarabine-based chemotherapy regimen has shown a satisfactory therapeutic effect on patients undergoing initial treatment for MZL, and the corresponding side effects can be well tolerated.",
        "keywords": [
            "Combination chemotherapy",
            "Fludarabine",
            "Lymphoma",
            "Marginal zone B-cell"
        ],
        "authors": [
            {
                "name": "Meifeng Tu",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Wen Zheng",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Yuntao Zhang",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Xiaopei Wang",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Yuqin Song",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Yan Xie",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Ningjing Lin",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Lingyan Ping",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Zhitao Ying",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Lijuan Deng",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Chen Zhang",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Jun Zhu",
                "org": "Peking University(Peking University),Beijing,China"
            }
        ],
        "venue": "Chinese Journal of Clinical Oncology",
        "year": 2011
    },
    "Unvq6fQR": {
        "id": "Unvq6fQR",
        "title": "Primary testicular non-Hodgkin's lymphoma: clinical analysis of 21 cases]",
        "abstract": "To explore the clinical characteristics and prognosis of patients with primary testicular non-Hodgkin's lymphoma.The clinical profiles and prognostic factors of 21 cases newly diagnosed as primary testicular non-Hodgkin's lymphoma at Peking University Cancer Hospital from January 2005 to December 2012 were retrospectively analyzed.Their median age was 59 (34-86) years. And they were classified as Ann Arbor stage I (n = 8), stage II (n = 2) and stage IV (n = 11). There were B symptoms (n = 4), extranodal involvement outside testis (n = 12) and elevated lactate dehydrogenase (LDH) at diagnosis (n = 6). The scores of international prognostic index (IPI) were 0-1 point (n = 10), 3 points (n = 10) and 4 points (n = 1). The regimens included orchidectomy as the initial treatment (n = 15), chemotherapy followed by radiotherapy (n = 7) and CNS prophylaxis during treatment (n = 15). All patients were pathologically diagnosed as diffuse large B-cell lymphoma. And 11 cases belonged to the non-germinal center B cell-like subgroup.First-line chemotherapy was either R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone) or CHOP-like-based regimen. Complete response was achieved in 85.7% of patients. The median follow-up period was 18 (6-58) months. The 1, 2 and 3-year survival rates were 100%, 80% and 60% respectively. Statistical analysis showed that the first-line chemotherapy with rituximab was a prognostic factor (P = 0.038).Other factors included stage (P = 0.275), LDH level (P = 0.179) , \u03b22-microglobulin level (P = 0.229) and IPI (P = 0.275) .The prognosis of primary testicular non-Hodgkin's lymphoma is usually poor. The first-line chemotherapy with rituximab is a prognostic factor.",
        "keywords": [
            "clinical characteristics",
            "prognosis",
            "non-hodgkin",
            "testis",
            "lymphoma"
        ],
        "authors": [
            {
                "name": "Chen Zhang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Xiao-pei Wang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Zhi-tao Ying",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Wen Zheng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Yan Xie",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Ning-jing Lin",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Ling-yan Ping",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Wei-ping Liu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Li-juan Deng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Yu-qin Song",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Jun Zhu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            }
        ],
        "venue": "Zhonghua yi xue za zhi",
        "year": 2013
    },
    "meJ6jMzw": {
        "id": "meJ6jMzw",
        "title": "Prognostic value of 18 F-fluorodeoxyglucose positron emission tomography using Deauville criteria in diffuse large B cell lymphoma treated with autologous hematopoietic stem cell transplantation.",
        "abstract": "PET results before and after HSCT are useful prognostic factors for DLBCL patients receiving HSCT. Patients who responded to chemotherapy, even those with positive pre-HSCT PET, are appropriate candidates for auto-HSCT.",
        "keywords": [
            "Positron emission tomography",
            "autologous hematopoietic stem cell transplantation",
            "computed tomography",
            "diffuse large B cell lymphoma",
            "high-dose chemotherapy"
        ],
        "authors": [
            {
                "name": "Zhitao Ying",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Lan Mi",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Nina Zhou",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Xuejuan Wang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Zhi Yang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Yuqin Song",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Xiaopei Wang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Wen Zheng",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Ningjing Lin",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Meifeng Tu",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Yan Xie",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Lingyan Ping",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Chen Zhang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Weiping Liu",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Lijuan Deng",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            },
            {
                "name": "Jun Zhu",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing 100142, China."
            }
        ],
        "venue": "Chinese journal of cancer research = Chung-kuo yen cheng yen chiu",
        "year": 2019
    },
    "8RnBg9EP": {
        "id": "8RnBg9EP",
        "title": "A prospective phase II study of L-asparaginase- CHOP plus radiation in newly diagnosed extranodal NK/T-cell lymphoma, nasal type.",
        "abstract": "To explore the efficacy and safety of L-asparaginase in newly-diagnosed extranodal nature killer (NK)/T -cell lymphoma (ENKTL), we conducted a prospective phase II study of L-asparaginase, cyclophosphamide, vincristine, doxorubicin and dexamethasone (CHOP-L) regimen in combination with radiotherapy.Patients with newly diagnosed ENKTL and an ECOG performance status of 0 to 2 were eligible for enrollment. Treatment included 6-8 cycles of CHOP-L (cyclophosphamide, 750 mg/m(2) day 1; vincristine, 1.4 mg/m(2) day 1 (maximal dose 2 mg), doxorubicin 50 mg/m(2) day 1; dexamethasone 10 mg days 1-8; L-asparaginase 6000 u/m(2) days 2-8). Radiotherapy was scheduled after 4-6 cycles of CHOP-L regimen, depending on stage and primary anatomic site. The primary endpoint was complete response (CR) rate.A total of 38 eligible patients were enrolled. The median age was 40.5 years (range, 15 to 71 years). Their clinical characteristics were male to female ratio, 24:14; Ann Arbor stage I, 20; II, 11; III, 3; IV, 4. CR and overall response rates were 81.6% (95% CI, 69.3% to 93.9%) and 84.2%, respectively. With a median follow-up of 25 months, the 2-year overall survival, progression-free survival and disease-free survival rates were 80.1% (95%CI, 73.3% to 86.9%), 81% (95%CI, 74.5% to 87.5%) and 93.6% (95%CI, 89.3% to 97.9%), respectively. The major adverse events were myelosuppression, liver dysfunction, and digestive tract toxicities. Grade 3 to 4 leukopenia and neutropenia were 76.3% and 84.2%, respectively. No treatment-related death was observed.CHOP-L chemotherapy in combination with radiotherapy is a safe and highly effective treatment for newly diagnosed ENKTL.",
        "keywords": [
            "prospective studies",
            "young adult"
        ],
        "authors": [
            {
                "name": "Ningjing Lin",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Yuqin Song",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Wen Zheng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Meifeng Tu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Yan Xie",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Xiaopei Wang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Lingyan Ping",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Zhitao Ying",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Chen Zhang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Lijuan Deng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Jun Zhu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            }
        ],
        "venue": "Journal of hematology & oncology",
        "year": 2013
    },
    "2mpZ5ouh": {
        "id": "2mpZ5ouh",
        "title": "Secondary central nervous system involvement in 599 patients with diffuse large B-cell lymphoma: are there any changes in the rituximab era?",
        "abstract": "The introduction of rituximab has improved the overall prognosis of diffuse large B-cell lymphoma (DLBCL). However, the impact of rituximab on central nervous system (CNS) involvement in DLBCL remains a matter of debate. Patients with DLBCL and no CNS involvement at initial diagnosis were eligible for this analysis. Patients must have received treatment either with CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) or CHOP plus rituximab (R-CHOP). We analyzed the incidence, clinical features and outcomes of CNS involvement that developed during or after completion of therapy. A cohort of 599 patients was eligible for this analysis. With a median follow-up of 26 and 21 months, respectively, 19 of 294 (6.5 %) in the CHOP group and 13 of 305 (4.3 %) in the R-CHOP group developed CNS involvement. Rituximab did not significantly reduce the risk of CNS involvement either in the univariate (P = 0.354) or in the multivariate analysis (RR 0.632, 95 % CI 0.301\u20131.327, P = 0.225). No patient developed CNS disease after 19 months in the R-CHOP group whereas four patients (21.1 %) in the CHOP group developed CNS disease 2 years after initial diagnosis (range 34\u201383 months). Systemic disease prior to or coincident with CNS occurrence was more common in the CHOP group than in the R-CHOP group (73.7 versus 38.5 %, P = 0.046). Isolated CNS events were more common in the R-CHOP group than those in the CHOP group (53.8 versus 10.5 %, P = 0.015). This study indicates that isolated CNS events are more common in DLBCL patients treated with R-CHOP than those treated with CHOP alone. Our data also suggest that the time and pattern of CNS events and systemic disease status differ with the addition of rituximab. Better methods for earlier detection and prophylaxis of CNS involvement are needed in the rituximab era.",
        "keywords": [
            "diffuse large b-cell lymphoma",
            "central nervous system",
            "r-chop",
            "dlbcl",
            "cns involvement",
            "rituximab",
            "Central nervous system",
            "CNS involvement",
            "Diffuse large B-cell lymphoma",
            "DLBCL",
            "R-CHOP",
            "Rituximab"
        ],
        "authors": [
            {
                "name": "Lijuan Deng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Yuqin Song",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Jun Zhu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Wen Zheng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Xiaopei Wang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Yan Xie",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Ningjing Lin",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Meifeng Tu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Lingyan Ping",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Zhitao Ying",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Chen Zhang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            }
        ],
        "venue": "International journal of hematology",
        "year": 2013
    },
    "AwCkyLhX": {
        "id": "AwCkyLhX",
        "title": "Safety and efficacy of bevacizumab combined with R-CHOP regimen in seven Chinese patients with untreated diffuse large B-cell lymphoma.",
        "abstract": "Rituximab plus CHOP (R-CHOP) significantly improved the outcome of diffuse large B cell lymphoma (DLBCL), a common sub-type of non-Hodgkin lymphoma. But 40% - 50% of DLBCL patients cannot be cured by this regimen. Some clinical trials showed that bevacizumab might be useful in the treatment of DLBCL. This study evaluated the safety and efficacy of bevacizumab combined with the R-CHOP (A-R-CHOP) regimen in Chinese patients with previously untreated DLBCL.Patients with previously untreated DLBCL received A-R-CHOP regimen therapy. All patients with complete response (CR)/ unconfirmed complete response(CRu) after 8 cycles of A-R-CHOP received the bevacizumab maintenance therapy once every 3 weeks. The remained bulky disease was treated with radiotherapy.Seven Chinese patients were treated. All of them had bulky diseases. One patient had progressive disease after 4 cycles of A-R-CHOP therapy. The rest six patients completed 8 cycles of A-R-CHOP treatment. All of these six patients reached CR/CRu (5 CR, 1 CRu). Bevacizumab maintenance therapy was given to 4 CR patients. All 7 patients experienced Grade 3/4 hematologic adverse events; additionally, one had Grade 3 gastrointestinal toxicity and one had Grade 1 epistaxis. During bevacizumab maintenance therapy, one patient had Grade 1 gingival bleeding, another experienced Grade 1 proteinuria and then Grade 3 congestive heart failure 4 months after completion of maintenance therapy. At the end of July 2013, the patient who had progressive disease after 4 cycles of A-R-CHOP died of progressive disease, the other six remained CR response.The A-R-CHOP regimen is effective for untreated DLBCL, but may cause bevacizumab-specific toxicities, which should be monitored.",
        "keywords": [
            "bevacizumab",
            "dlbcl",
            "efficacy",
            "safety",
            "biomedical research",
            "cancer research",
            "bioinformatics",
            "cell biology"
        ],
        "authors": [
            {
                "name": "Zhiying Fu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Jun Zhu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Wen Zheng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Zhitao Ying",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Yan Xie",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Xiaopei Wang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Ningjing Lin",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Meifeng Tu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Lingyan Ping",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Lijuan Deng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Chen Zhang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Ning Ding",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Yuqin Song",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            }
        ],
        "venue": "Cancer cell international",
        "year": 2014
    },
    "LuwyyJkP": {
        "id": "LuwyyJkP",
        "title": "A safe and potent anti-CD19 CAR T cell therapy.",
        "abstract": "Anti-CD19 chimeric antigen receptor (CAR) T cell therapies can cause severe cytokine-release syndrome (CRS) and neurotoxicity, impeding their therapeutic application. Here we generated a new anti-CD19 CAR molecule (CD19-BBz(86)) derived from the CD19-BBz prototype bearing co-stimulatory 4-1BB and CD3\u03b6 domains. We found that CD19-BBz(86) CAR T cells produced lower levels of cytokines, expressed higher levels of antiapoptotic molecules and proliferated more slowly than the prototype CD19-BBz CAR T cells, although they retained potent cytolytic activity. We performed a phase 1 trial of CD19-BBz(86) CAR T cell therapy in patients with B cell lymphoma (ClinicalTrials.gov identifier NCT02842138 ). Complete remission occurred in 6 of 11 patients (54.5%) who each received a dose of 2\u2009\u00d7\u200910-4\u2009\u00d7\u200910 CD19-BBz(86) CAR T cells. Notably, no neurological toxicity or CRS (greater than grade 1) occurred in any of the 25 patients treated. No significant elevation in serum cytokine levels after CAR T cell infusion was detected in the patients treated, including in those who achieved complete remission. CD19-BBz(86) CAR T cells persistently proliferated and differentiated into memory cells in vivo. Thus, therapy with the new CD19-BBz(86) CAR T cells produces a potent and durable antilymphoma response without causing neurotoxicity or severe CRS, representing a safe and potent anti-CD19 CAR T cell therapy.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhitao Ying",
                "org": "Key Laboratory of Carcinogenesis and Translational Research, Departments of Lymphoma, Radiology and Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China."
            },
            {
                "name": "Xue F Huang",
                "org": "Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA."
            },
            {
                "name": "Xiaoyu Xiang",
                "org": "Marino Biotechnology Corp., Beijing, China."
            },
            {
                "name": "Yanling Liu",
                "org": "Marino Biotechnology Corp., Beijing, China."
            },
            {
                "name": "Xi Kang",
                "org": "Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA."
            },
            {
                "name": "Yuqin Song",
                "org": "Key Laboratory of Carcinogenesis and Translational Research, Departments of Lymphoma, Radiology and Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China."
            },
            {
                "name": "Xiaokai Guo",
                "org": "Marino Biotechnology Corp., Beijing, China."
            },
            {
                "name": "Hanzhi Liu",
                "org": "Marino Biotechnology Corp., Beijing, China."
            },
            {
                "name": "Ning Ding",
                "org": "Key Laboratory of Carcinogenesis and Translational Research, Departments of Lymphoma, Radiology and Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China."
            },
            {
                "name": "Tingting Zhang",
                "org": "Marino Biotechnology Corp., Beijing, China."
            },
            {
                "name": "Panpan Duan",
                "org": "Marino Biotechnology Corp., Beijing, China."
            },
            {
                "name": "Yufu Lin",
                "org": "Key Laboratory of Carcinogenesis and Translational Research, Departments of Lymphoma, Radiology and Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China."
            },
            {
                "name": "Wen Zheng",
                "org": "Key Laboratory of Carcinogenesis and Translational Research, Departments of Lymphoma, Radiology and Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China."
            },
            {
                "name": "Xiaopei Wang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research, Departments of Lymphoma, Radiology and Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China."
            },
            {
                "name": "Ningjing Lin",
                "org": "Key Laboratory of Carcinogenesis and Translational Research, Departments of Lymphoma, Radiology and Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China."
            },
            {
                "name": "Meifeng Tu",
                "org": "Key Laboratory of Carcinogenesis and Translational Research, Departments of Lymphoma, Radiology and Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China."
            },
            {
                "name": "Yan Xie",
                "org": "Key Laboratory of Carcinogenesis and Translational Research, Departments of Lymphoma, Radiology and Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China."
            },
            {
                "name": "Chen Zhang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research, Departments of Lymphoma, Radiology and Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China."
            },
            {
                "name": "Weiping Liu",
                "org": "Key Laboratory of Carcinogenesis and Translational Research, Departments of Lymphoma, Radiology and Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China."
            },
            {
                "name": "Lijuan Deng",
                "org": "Key Laboratory of Carcinogenesis and Translational Research, Departments of Lymphoma, Radiology and Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China."
            },
            {
                "name": "Shunyu Gao",
                "org": "Key Laboratory of Carcinogenesis and Translational Research, Departments of Lymphoma, Radiology and Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China."
            },
            {
                "name": "Lingyan Ping",
                "org": "Key Laboratory of Carcinogenesis and Translational Research, Departments of Lymphoma, Radiology and Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China."
            },
            {
                "name": "Xuejuan Wang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research, Departments of Lymphoma, Radiology and Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China."
            },
            {
                "name": "Nina Zhou",
                "org": "Key Laboratory of Carcinogenesis and Translational Research, Departments of Lymphoma, Radiology and Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China."
            },
            {
                "name": "Junqing Zhang",
                "org": "Marino Biotechnology Corp., Beijing, China."
            },
            {
                "name": "Yulong Wang",
                "org": "Marino Biotechnology Corp., Beijing, China."
            },
            {
                "name": "Songfeng Lin",
                "org": "Marino Biotechnology Corp., Beijing, China."
            },
            {
                "name": "Mierzhati Mamuti",
                "org": "Marino Biotechnology Corp., Beijing, China."
            },
            {
                "name": "Xueyun Yu",
                "org": "Marino Biotechnology Corp., Beijing, China."
            },
            {
                "name": "Lizhu Fang",
                "org": "Marino Biotechnology Corp., Beijing, China."
            },
            {
                "name": "Shuai Wang",
                "org": "Marino Biotechnology Corp., Beijing, China."
            },
            {
                "name": "Haifeng Song",
                "org": "Marino Biotechnology Corp., Beijing, China."
            },
            {
                "name": "Guan Wang",
                "org": "Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA."
            },
            {
                "name": "Lindsey Jones",
                "org": "Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA."
            },
            {
                "name": "Jun Zhu",
                "org": "Key Laboratory of Carcinogenesis and Translational Research, Departments of Lymphoma, Radiology and Nuclear Medicine, Peking University Cancer Hospital and Institute, Beijing, China. zhujun@csco.org.cn."
            },
            {
                "name": "Si-Yi Chen",
                "org": "Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. siyichen@usc.edu."
            }
        ],
        "venue": "Nature medicine",
        "year": 2019
    },
    "pquCSgcq": {
        "id": "pquCSgcq",
        "title": "The efficacy and safety of the DICE regimen in combination with rh-endostatin (Endostar) in the treatment of recurrent or refractory diffuse large B-cell lymphoma: A prospective clinical trial",
        "abstract": "Objective: To evaluate the efficacy and safety of the DICE regimen in combination with recombinant human endostatin (Endostar) in patients with recurrent or refractory DLBCL (diffuse large B-cell lymphoma). Methods: DICE regimen were given intravenously for 4 consecutive days, consisting of dexamethasone 10 mg/d, ifosfamide 1 g\u00b7m-2\u00b7d -1, cisplatin 25 mg\u00b7m-2\u00b7d-1, and etoposide 60 mg\u00b7m-2\u00b7d-1. Endostar were given at 7.5 mg/m2 (i.v.) on days 1-14. Cycles were repeated every 3 or 4 weeks. Results: Between January 2009 and September 2011, 15 patients with recurrent or refractory DLBCL were enrolled: 11(73.3%) with primary refractory lymphoma and 4 (26.7%) with recurrent lymphoma. Two patients (13.3%) achieved a complete remission and 2 (13.3%) achieved a partial remission. The overall response rate was 26.7%. The clinical factors of gender (P = 0.011), International Prognostic Index (P = 0.033) and serum lactate dehydrogenase level (P = 0.011) had significant effects on overall response rate. The TTF (median time to treatment failure) and the OS (overall survival) time were 2 and 10 months, respectively. The one-year OS rate and the TTF rate were 46.7% and 26.7%, respectively. Myelosuppression was the major toxicity. WHO grade III/IV leukopenia and granulocytopenia were developed in 11 patients (78.6%). Conclusion: DICE regimen in combination with Endostar was well tolerated and its efficacy was mild in patients with recurrent or refractory DLBCL, probably due to these extremely poor prognostic patients. Copyright \u00a9 2013 by TUMOR.",
        "keywords": [
            "DICE regimen",
            "Diffuse large B-cell lymphoma",
            "Non-hodgkin lymphoma",
            "Recombinant human endostatin",
            "Recurrent",
            "Refractory"
        ],
        "authors": [
            {
                "name": "LIN Ning-jing",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "SONG Yu-qin",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Wen Zheng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "TU Mei-feng",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "FU Zhi-ying",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Yan Xie",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "WANG Xiao-pei",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "PING Ling-yan",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "YING Zhi-tao",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Chen Zhang",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "DENG Li-juan",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            },
            {
                "name": "Jun Zhu",
                "org": "Beijing Cancer Hospital(Cancer Hospital),Beijing,China"
            }
        ],
        "venue": "Tumor",
        "year": 2013
    },
    "pdrc7ld1": {
        "id": "pdrc7ld1",
        "title": "FIRST-LINE L-ASPARAGINASE-BASED CHEMOTHERAPY PLUS RADIOTHERAPY IS ACTIVE IN STAGE I/II EXTRANODAL NK/T-CELL LYMPHOMA: RESULTS FROM PEKING UNIVERSITY CANCER HOSPITAL",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yuqin Song",
                "org": ""
            },
            {
                "name": "J. Jia",
                "org": "Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China"
            },
            {
                "name": "M. Wu",
                "org": "Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China"
            },
            {
                "name": "X. Leng",
                "org": "Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China"
            },
            {
                "name": "Ningjing Lin",
                "org": "Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China"
            },
            {
                "name": "Yan Xie",
                "org": "Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China"
            },
            {
                "name": "Wen Zheng",
                "org": "Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China"
            },
            {
                "name": "Xuejuan Wang",
                "org": "Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China"
            },
            {
                "name": "Lingyan Ping",
                "org": "Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China"
            },
            {
                "name": "Meifeng Tu",
                "org": "Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China"
            },
            {
                "name": "Zhitao Ying",
                "org": "Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China"
            },
            {
                "name": "Chen Zhang",
                "org": "Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China"
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Lijuan Deng",
                "org": "Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China"
            },
            {
                "name": "Jun Zhu",
                "org": "Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China"
            }
        ],
        "venue": "Hematological Oncology",
        "year": 2017
    },
    "0cT8RiCy": {
        "id": "0cT8RiCy",
        "title": "Parallel Comparison of 4-1BB or CD28 Co-stimulated CD19-Targeted CAR-T Cells for B Cell Non-Hodgkin's Lymphoma.",
        "abstract": "CD19-targeted chimeric antigen receptor-T (CAR-T) cells with CD28 or 4-1BB (28z CAR-T and BBz CAR-T) have shown great promise to treat relapsed or refractory (r/r) B cell non-Hodgkin's lymphoma (B-NHL). However, comparison of their clinical outcomes has never been reported. This study investigated their efficacy and adverse events in B-NHL therapy. Six patients with r/r B-NHL were initially enrolled and infused with 28z or BBz CAR-T cells at a dose of 0.75-5\u00a0\u00d7 10/kg. These CAR-T cells showed similar antitumor efficacies, with a complete response (CR) rate of 67% within 3\u00a0months. BBz CAR-T was well tolerated. However, severe cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome occurred in the 28z CAR-T cohort, resulting in the termination of further evaluation of 28z CAR-T. Three more patients were enrolled to investigate BBz CAR-T cells in-depth at an escalated dose (1\u00a0\u00d7 10/kg). All cases achieved CR within 3\u00a0months, and only grade 1/2 adverse events occurred. This study suggests that 4-1BB is more beneficial for the clinical performance of CAR-T cells than CD28 in CD19-targeted B-NHL therapy, at least under our manufacturing process.",
        "keywords": [
            "B cell non-Hodgkin\u2019s lymphoma",
            "CD19-targeted chimeric antigen receptor-T cells",
            "co-stimulatory domain"
        ],
        "authors": [
            {
                "name": "Zhitao Ying",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China."
            },
            {
                "name": "Ting He",
                "org": "Immunochina Pharmaceuticals Co., Ltd., Beijing, China."
            },
            {
                "name": "Xiaopei Wang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China."
            },
            {
                "name": "Wen Zheng",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China."
            },
            {
                "name": "Ningjing Lin",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China."
            },
            {
                "name": "Meifeng Tu",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China."
            },
            {
                "name": "Yan Xie",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China."
            },
            {
                "name": "Lingyan Ping",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China."
            },
            {
                "name": "Chen Zhang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China."
            },
            {
                "name": "Weiping Liu",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China."
            },
            {
                "name": "Lijuan Deng",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China."
            },
            {
                "name": "Feifei Qi",
                "org": "Immunochina Pharmaceuticals Co., Ltd., Beijing, China."
            },
            {
                "name": "Yanping Ding",
                "org": "Immunochina Pharmaceuticals Co., Ltd., Beijing, China."
            },
            {
                "name": "Xin-An Lu",
                "org": "Immunochina Pharmaceuticals Co., Ltd., Beijing, China."
            },
            {
                "name": "Yuqin Song",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China."
            },
            {
                "name": "Jun Zhu",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China."
            }
        ],
        "venue": "Molecular therapy oncolytics",
        "year": 2019
    },
    "vfZJZOjq": {
        "id": "vfZJZOjq",
        "title": "Effect of copper aspirinate on contraction of isolated rabbit aortic strips",
        "abstract": "AIM: To investigate the effect of copper aspirinate on contraction of vascular smooth muscle. METHODS: Isolated rabbit aortic strips, including intact endothelium strips and endothelial cell-denuded aortic strips, were suspended in modified Krebs solution to determine effects of copper aspirinate on the contraction induced by norepinephrine (NE), KCl, and CaCl2, while CuSO4, aspirin, and vehicle were used as controls. RESULTS: Copper aspirinate possessed antagonistic effect on contraction of rabbit aortic strips induced by NE with an IC50 value of 31 nmol/L, while CuSO4 had much less antagonistic effect with an IC50 value of 0.29 \u03bcmol/L, and aspirin did not work in the same preparation. No effect of copper aspirinate were found on the contraction induced by KCl and CaCl2. Effects on endothelial cell denuded aortic strips were similar to those in the normal aortic strips. CONCLUSION: Copper aspirinate possessed different effects from aspirin and CuSO4 on vascular smooth muscles. It inhibited contraction induced by NE with an activity stronger than CuSO4 at the same Cu2+ concentration, this action might be due to blockade of the receptor-operated Ca2+ channels, and it might not be linked to the endothelium.",
        "keywords": [
            "Aorta",
            "Copper aspirinate",
            "Vascular endothelium",
            "Vascular smooth muscle"
        ],
        "authors": [
            {
                "name": "Weimin Yang",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "ZhiQiang Shen",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "ZhiHe Chen",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "Ling Li",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "Fei Peng",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            }
        ],
        "venue": "Acta Pharmacologica Sinica",
        "year": 2001
    },
    "OthHx1LG": {
        "id": "OthHx1LG",
        "title": "Effect of Cu(\u2161)_2(acetylsalicylate)_4 on inhibition of growth and induced apoptosis in HCT-116 human colon adenocarcinoma cells",
        "abstract": "Objective:To study the effect of Cu (\u2161)_2(acetylsaiicylate)_4 on the inhibition of growth and the induced apoptosis in HCT-116 cells.Methods:The toxicity of Cu(\u2161)_2(acetylsalicylate)_4 to HCT-116 cells was detected by MTT assay,and the effect on the induced apoptosis was detected by Fluoroscope and flow eytometer.Results:When HCT-116 cells were treated by Cu (\u2161)_2(acetyl-salicylate)_4 for 48h and 72h,the IC_50 were 6.10\u03bcmol/L and 4.48\u03bcmol/L respec- tively.Nucleus cleavage and apoptotic bodies were observed when HCT-116 cells were treated by Cu (\u2161)_2(acetylsalicy- late)_4(10\u03bcmol/L) for 24 h;and an obvious subdiploid peak exhibited when HCT-I16 cells were treated by Cu(\u2161)_2 (acetylsalicylate)_4 (10\u03bcmol/L) for 48 h,trod the rate of apoptosis was 34.1%.Apoptosis was dependent on concentra- tion and time.Conclusion:The results suggest that Cu (\u2161)_2(acetylsalicylate)_4 can significantly inhibit the growth of HCT- 116 cells and induce the apoptosis.",
        "keywords": [
            "Cu(\u2161)_2(acetylsalicylate)_4",
            "human colon adenocarcinoma ceils",
            "apoptosis"
        ],
        "authors": [
            {
                "name": "ZHANG Feng",
                "org": "Kunming Medical College,Kunming ,China"
            },
            {
                "name": "LEI Xiu-ling",
                "org": "Kunming Medical College,Kunming ,China"
            },
            {
                "name": "ZHAI Ai-feng",
                "org": "Kunming Medical College,Kunming ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Kunming Institute of Precious Metals,Kunming ,China"
            }
        ],
        "venue": "Journal of Taishan Medical College",
        "year": 2006
    },
    "7VuGXlUw": {
        "id": "7VuGXlUw",
        "title": "Stability of Combination Use of Lobaplatin for Injection and Sodium Chloride Injection",
        "abstract": "Objective To investigate the stability of combination use of lobaplatin for injection and sodium chloride injection at different temperatures(25\u2103,37\u2103)in order to provide theoretical basis for its clinical reasonable application.Methods Lobaplatin for injection was dissolved in sodium chloride injection,and the mixed solution was placed at different temperatures.HPLC was used to detect the changes in lobaplatin content in sodium chloride injection at 25 \u2103 and 37 \u2103 within 24 h.Results Lobaplatin for injection in sodium chloride injection at 25 \u2103 and 37 \u2103 for 24hshowed no significant changes.Conclusion Lobaplatin for injection can be used in combine with sodium chloride injection.",
        "keywords": [
            "combination stability",
            "lobaplatin for injection",
            "sodium chloride injection"
        ],
        "authors": [
            {
                "name": "Jiang Jing",
                "org": ""
            },
            {
                "name": "Yang Shuiyan",
                "org": ""
            },
            {
                "name": "Ren Yanli",
                "org": ""
            },
            {
                "name": "Yu Juan",
                "org": ""
            },
            {
                "name": "Yan Caixian",
                "org": ""
            },
            {
                "name": "Liu Weiping",
                "org": ""
            }
        ],
        "venue": "Chinese Pharmaceutical Affairs",
        "year": 2013
    },
    "GU1QBFXh": {
        "id": "GU1QBFXh",
        "title": "Synthesis and anticancer activity of [2-hydroxy-1,3-diaminopropane- \u03ba 2 N , N \u2032] platinum(II) complexes",
        "abstract": "",
        "keywords": [
            "hydrogen bond",
            "structure",
            "cell line",
            "x ray diffraction"
        ],
        "authors": [
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "xizhu chen",
                "org": ""
            },
            {
                "name": "mingjin xie",
                "org": ""
            },
            {
                "name": "liguang lou",
                "org": ""
            },
            {
                "name": "qingsong ye",
                "org": ""
            },
            {
                "name": "yao yu",
                "org": ""
            },
            {
                "name": "shuqian hou",
                "org": ""
            }
        ],
        "venue": "Journal of Inorganic Biochemistry",
        "year": 2008
    },
    "T7iHT2QX": {
        "id": "T7iHT2QX",
        "title": "Stereoisomeric separation and toxicity of a new organophosphorus insecticide chloramidophos.",
        "abstract": "Chloramidophos (CP), O,S-dimethyl-[(2,2,2)-trichloro-1-hydroxyethyl]phosphoramidothioate, is a new organophosphorus pesticide (OP) with two chiral centers each on the phosphorus and carbon atoms. Although CP has been widely used in some provinces of China, it has received very limited attention toward its environmental behaviors, in particular, with regard to stereospecificity. In this study, the stereoisomeric separation and toxicity of CP were investigated. All of the four stereoisomers of CP were successfully separated by high-performance liquid chromatography on a Chiralpak AD column. The stereoisomers (pk 1 to pk 4) were distinguishable on their mass and circular dichroism spectra. The inhibition on acetylcholinesterases (AChE, in vitro) and the acute aquatic toxicity to Daphnia magna (in vivo) tested with optically pure stereoisomers of CP showed its stereoselectivity. The inhibitory potency toward AChE decreased in the order of pk 4 > pk 3 > pk 2 > pk 1. In comparison, the acute toxicity to D. magna was in the order of pk 3 > pk 2 > pk 1 > pk 4. The stereoselectivity was found to be isomer-dependent, with 1.1-18.1-fold differences (in vitro) and 1.2-13-fold differences (in vivo) among the stereoisomers. These results suggest that the overall toxicity of chiral OPs should be assessed using their individual enantiomers.",
        "keywords": [],
        "authors": [
            {
                "name": "Shanshan Zhou",
                "org": ""
            },
            {
                "name": "Kunde Lin",
                "org": ""
            },
            {
                "name": "Huayun Yang",
                "org": ""
            },
            {
                "name": "Ling Li",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Jian Li",
                "org": ""
            }
        ],
        "venue": "Chemical research in toxicology",
        "year": 2007
    },
    "baP9veFQ": {
        "id": "baP9veFQ",
        "title": "A Germylene/Borane Lewis Pair and the Remarkable C=O Bond Cleavage Reaction toward Isocyanate and Ketone Molecules.",
        "abstract": "A germylene/borane Lewis pair (2) was prepared from a 1,1-carboboration of amidinato phenylethynylgermylene (1) by B(C6 F5 )3 . Compound 2 reacted with iPrNCO and (4-MeOC6 H4 )C(O)Me, respectively, with cleavage of the C=O double bond. In the first instance, O and iPrNC insert separately into the Ge-B bond to yield a GeBC2 O-heterocycle (3) and a GeBC3 -heterocycle (4). In the second case (4-MeOC6 H4 )(Me)C inserts into the Ge-N bond of 2 while O is incorporated in the Ge-B bond to form a Ge-centered spiroheterocycle (5). The reaction of 2 with tBuNC to give 6, which has almost the same structure as 4, proved the formation of the isonitrile during transformation from 2 and iPrNCO to 3 and 4. The kinetic study of the reaction of 2 and iPrNCO gave evidence of proceeding through a GeBC3 O-heterocycle intermediate. In addition, a DFT study was performed to elucidate the reaction mechanism. ",
        "keywords": [
            "C=O bond cleavage",
            "coordination chemistry",
            "density functional calculations",
            "germylene/borane Lewis pairs",
            "isonitrile"
        ],
        "authors": [
            {
                "name": "Jiancheng Li",
                "org": "State Key Laboratory of Physical Chemistry of Solid Surfaces, National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P. R. China."
            },
            {
                "name": "Bin Li",
                "org": "State Key Laboratory of Physical Chemistry of Solid Surfaces, National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P. R. China."
            },
            {
                "name": "Rui Liu",
                "org": "State Key Laboratory of Physical Chemistry of Solid Surfaces, National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P. R. China."
            },
            {
                "name": "Liuyin Jiang",
                "org": "State Key Laboratory of Physical Chemistry of Solid Surfaces, National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P. R. China."
            },
            {
                "name": "Hongping Zhu",
                "org": "State Key Laboratory of Physical Chemistry of Solid Surfaces, National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P. R. China. hpzhu@xmu.edu.cn."
            },
            {
                "name": "Herbert W Roesky",
                "org": "Institut f\u00fcr Anorganische Chemie, Georg-August-Universit\u00e4t, Tammannstra\u00dfe 4, 37077, G\u00f6ttingen, Germany. hroesky@gwdg.de."
            },
            {
                "name": "Sayan Dutta",
                "org": "Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, 741246, India."
            },
            {
                "name": "Debasis Koley",
                "org": "Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, 741246, India. koley@iiserkol.ac.in."
            },
            {
                "name": "Weiping Liu",
                "org": "State Key Laboratory for Platinum Group Metals, Kunming Institute of Precious Metals, Kunming, Yunnan, 650106, P. R. China."
            },
            {
                "name": "Qingsong Ye",
                "org": "State Key Laboratory for Platinum Group Metals, Kunming Institute of Precious Metals, Kunming, Yunnan, 650106, P. R. China."
            }
        ],
        "venue": "Chemistry (Weinheim an der Bergstrasse, Germany)",
        "year": 2016
    },
    "UlmZEybv": {
        "id": "UlmZEybv",
        "title": "Enantioselective cytotoxicity of isocarbophos is mediated by oxidative stress-induced JNK activation in human hepatocytes.",
        "abstract": "Recent studies have shown the enantioselectivity of chiral pesticides in environmental fate, aquatic toxicity, endocrine disruption and cytotoxicity. Thus it is of significance to investigate the molecular mechanisms of chiral pesticides enantioselectivity in cytotoxicity. In the present study, we used Hep G2 cells as in vitro model to assay cytotoxicity of enantiomers of isocarbophos (ICP), a widely used chiral organophosphorus pesticide. The results of cell viability assay and cytoflow assay indicated an obvious enantioselective hepatocyte toxicity of ICP: (-)-ICP was about two times more toxic than (+)-ICP in Hep G2 cells. We found that (-)-ICP, but not (+)-ICP, up-regulated Bax protein expression and down-regulated Bcl-2 expression levels, which resulted in an increase in Bax/Bcl-2 ratio with the apoptosis co-ordination. Although (-)-ICP enantioselectively activated both ERK and JNK, only the specific inhibitor for JNK could completely reverse (-)-ICP-induced apoptosis of Hep G2 cells. It suggests that (-)-ICP-induced hepatocyte toxicity was more dominantly through the sustained activation of JNK pathway, but only partially via ERK cascade. Furthermore, (-)-ICP induced ROS production, while (+)-ICP had no effect on ROS generation. The antioxidant MnTBAP attenuated (-)-ICP-induced activation of JNK and ERK, indicating that the outcome from challenge with (-)-ICP enantiomer depends on the oxidative stress-induced activation of a series of signaling cascades that promote hepatocyte apoptosis. In conclusion, (-)-ICP enantioselectively causes the change of Bax/Bcl-2 ratio, triggers the generation of intracellular ROS and sequentially induces sustainable activation of JNK, which in turn, results in a decrease in cell viability and an increase in cell apoptosis. Our observations provide further insight into enantiomers toxicity pathway which is able to differentiate between enantiomer activities at molecular level.",
        "keywords": [
            "5-dimethylthiazol-2-yl)-2",
            "extracellular signal-regulated kinase",
            "icp",
            "mapk",
            "organophosphorus pesticides",
            "erk",
            "ops",
            "jnk pathway",
            "cytotoxicity",
            "jnk",
            "mitogen-ctivated protein kinase",
            "3-(4",
            "mtt",
            "pvdf",
            "isocarbophos",
            "enantioselectivity",
            "chiral pesticide",
            "hplc",
            "polyvinylidene difluoride",
            "5-diphenyl tetrazolium bromide",
            "high-performance liquid chromatography",
            "c-jun n-terminal kinase",
            "protein expression",
            "molecular mechanics",
            "cell viability"
        ],
        "authors": [
            {
                "name": "Huigang Liu",
                "org": ""
            },
            {
                "name": "Jing Liu",
                "org": ""
            },
            {
                "name": "Lihong Xu",
                "org": "Department of Biochemistry and Genetics, School of Medicine, Zhejiang University, Hangzhou 310058, People's Republic of China"
            },
            {
                "name": "Shanshan Zhou",
                "org": "Research Center of Green Chirality, College of Biology and Environment, Zhejiang University of Technology, Hangzhou 310032, People's Republic of China"
            },
            {
                "name": "Ling Li",
                "org": "Research Center of Green Chirality, College of Biology and Environment, Zhejiang University of Technology, Hangzhou 310032, People's Republic of China"
            },
            {
                "name": "Weiping Liu",
                "org": ""
            }
        ],
        "venue": "Toxicology",
        "year": 2010
    },
    "CJiqZFlG": {
        "id": "CJiqZFlG",
        "title": "(1,3-Diamino-propan-2-ol-\u03ba2 N,N\u2032)(3-hydroxy-cyclo- butane-1,1-dicarboxyl-ato-\u03ba2 O,O\u2032)platinum(II) monohydrate",
        "abstract": "The reaction of 2-hydr-oxy-1,3-diamino-propane and 1,1-cyclo-butane- dicarboxylic acid with potassium tetra-chloro-platinate(II) yielded the monomeric title complex, [Pt(C6H6O5)(C3H6N2O)]\u00b7H2O. The PtII atom, coordinated by two N atoms of diamino-propane and two O atoms of carboxyl-ato groups, is in a sqare-planar environment. O - H\u22efO hydrogen bonds between the ligands and the solvent water mol-ecule create a three-dimensional network. \u00a9 2007 International Union of Crystallography. All rights reserved.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Mingjin Xie",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            },
            {
                "name": "Xizhu Chen",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Yao Yu",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Qing Shong Ye",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            }
        ],
        "venue": "Acta Crystallographica Section E: Structure Reports Online",
        "year": 2007
    },
    "Q9NYZBvr": {
        "id": "Q9NYZBvr",
        "title": "Single and Joint Acute Toxicity of Isocarbophos Enantiomers to<i>Daphnia magna</i>",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Kunde Lin",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Ling Li",
                "org": ""
            },
            {
                "name": "Jay Gan",
                "org": ""
            }
        ],
        "venue": "Journal of Agricultural and Food Chemistry",
        "year": 2008
    },
    "V4quhZc4": {
        "id": "V4quhZc4",
        "title": "Hepatotoxicity of heptaplatin and a new platinum complex LLC-0601 in SD rats",
        "abstract": "OBJECTIVE: To investigate the hepatotoxicity of heptaplatin and LLC-0601 in SD rats, and to explore the toxic mechanisms. METHODS: Rats were respectively injected with cisplatin 2 mg\u00b7kg -1 (positive control), heptaplatin 40 mg\u00b7kg -1 and LLC-0601 40 and 70 mg\u00b7kg -1, once a day, for 2 d, and then an inteval for 5 d, all 3 courses for 6 injections, and then rats restored for 28 d. After the last 24 h after administration and after restoration 28 d, the rats were inspected for their general condition. Serum biochemistry indices glutamic pyruvic transaminase (GPT), glutamic oxaloacetic transaminase (GOT), alkaline phosphatase (ALP), total protein (TP), albumin (ALB) and total bilirubin (T-Bil) were detected. Liver mass and coefficients were detected. The activity of glutathione peroxidase (GSH-Px), total superoxide dismutase (T-SOD) and malondialdehyde (MDA) was examined and liver histopathology was observed. RESULTS: Compared with normal control group, rats in treated groups except LLC-0601 70 mg\u00b7kg -1 appeared to be dispirited, and mat, food intake decreased, significant vertical hair phenomena, with a reduction of activity. GPT was higher, but TP and ALB were lower in heptaplatin group (P < 0.05). Compared with normal control group, liver mass and organ coefficients, GSH-Px and T-SOD were lower in the drug-treated groups (P < 0.05). While MDA was significantly higher (P < 0.05). Liver tissue in cisplatin, heptapletin and LLC-0601 70 mg\u00b7kg -1 groups showed focal necrosis and sinusoidal lymphocytic infiltration of liver cells. After 28 d restoration all indices returned to normal except cisplatin group. CONCLUSION: Heptaplatin and LLC-0601 can induce liver damage and the mechanism may be related to their oxidative damage.",
        "keywords": [
            "Liver",
            "LLC-0601",
            "Platinum compounds",
            "Toxic actions"
        ],
        "authors": [
            {
                "name": "WANG Zhen-yu",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "Rong Mei",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "SONG Jing-feng",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "Wei Ping Liu",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Ying Lu",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            }
        ],
        "venue": "Chinese Journal of Pharmacology and Toxicology",
        "year": 2011
    },
    "MVfuEeKK": {
        "id": "MVfuEeKK",
        "title": "The photolytical products of aqueous carboplatin solution",
        "abstract": "null",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Zhen Huan Que",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Yikun Yang",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Huizhou Xiong",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            }
        ],
        "venue": "Yaoxue Xuebao",
        "year": 1996
    },
    "uaYyeDoE": {
        "id": "uaYyeDoE",
        "title": "The antilipolytic action of bis(\u03b1-furancarboxylato)oxovanadium(IV) in adipocytes",
        "abstract": "Results FFA release from adipocytes treated with epinephrine was markedly inhibited by BFOV and vanadyl sulfate, with the IC 50 values of 0.30 \u00b10.20 and 0.46 \u00b1 0.26\u00a0mmol/l, respectively, but not by insulin. Whereas, the inhibition of vanadyl compounds on FFA release triggered by forskolin in adipocytes were not observed. BFOV dose-dependently reduced serum triglycerides and FFA concentrations when compared with untreated diabetic rats ( P < 0.05), while it did not influence cholesterol concentrations, similar to vanadyl sulfate. Serum leptin concentration was also decreased both in the BFOV- and vanadyl sulfate-treated diabetic group ( P < 0.05). Moreover, BFOV markedly reduced blood glucose concentration and food intake ( P < 0.05), but it did not change the body weight of diabetic rats. Conclusion BFOV has an antilipolytic action in adipocytes mediated by catecholamines. This action was distinct from that of insulin and also not related to inhibiting the activity of adenylate cyclase. In vivo, BFOV could improve dyslipidemia and leptin sensitivity in fat-fed/STZ-diabetic rats. Keywords Bis(\u03b1-furancarboxylato)oxovanadium(IV) Fat-fed/streptozotocin rats Lipid Adipocyte Lipolysis 1 Introduction It is well known that the complications of atherosclerotic macrovascular disease account for the majority of deaths and a disproportionate amount of morbidity in patients with diabetes. The increased concentrations of lipids pose the diabetic patients with a greater risk factor for the development of coronary heart disease. Inadequate utilization of glucose in diabetic models or in diabetic patients stimulates the mobilization of storage lipids, increasing triglycerides and FFA [1] . Increased plasma concentrations of FFA are thought to play a major role in the pathogenesis of insulin resistance and type 2 diabetes [2,3] by inhibiting glucose uptake and utilization by muscle [4] and causing increased glucose output by liver [5] . These disorders of fat metabolism, therefore, contribute to promote and maintain the alterations of glucose homeostasis [6] . Vanadium, an essential nutritional element in higher animals, has also been proposed as an in vivo regulator of cell metabolism. Vanadium compounds have been known to possess insulinmimetic and/or enhancing effects both in vitro and in vivo via a postreceptor mechanism. Vanadate inhibits phosphotyrosine phosphatases (PTPs) activity and increases tyrosine phosphorylation of insulin substrate proteins [7\u20139] . Various vanadyl complexes with different ligands have been synthesized and their antidiabetic effects have been reported. An important advancement in the use of vanadium compounds as insulin mimics has been the development of various ligands in order to reduce the toxicity and improve the absorption, tissue uptake and efficiency of vanadium. One example is bis(\u03b1-furancarboxylato)oxovanadium(IV) (BFOV, Fig. 1 ) in which the vanadyl ions are held in a bidentate-chelating framework that imparts thermodynamic stability and lipophicity to the compounds. With the hypoglycemic potency of the vanadium complex in type 1 and type 2 diabetic animals [10\u201313] , we evaluated the hypolipidemic efficacy of the complex, in order to elaborate BFOV as a potent oral anti-diabetogenic drug. Hence the present paper reports the effect of BFOV in ameliorating dyslipidemia in fat-fed STZ-induced diabetic rats, a model of type 2-like diabetic rats, and its antilipolytic action in isolated rat adipocytes, by using several agonists relevant to stimulating FFA release. 2 Materials and methods 2.1 Reagents BFOV (purity > 98.5% by HPLC) was synthesized according to the method described previously [12] . Vanadyl sulfate (VOSO 4 ) was the product of Acros Origanics. STZ, collagenase (Type II), (6)-epinephrine hydrochloride (epinephrine) and forskolin were purchased from Sigma. Bovine serum albumin (BSA; fraction V) was the product of Roche. The biochemical kits used in this experiment were purchased from Shanghai Rongsheng Bioengineering Institute, Nanjing Jiancheng Bioengineering Institute, and China Institute of Atomic Energy. All other reagents were of analytical grade commercially available. 2.2 Animals Male Sprague\u2013Dawley rats, weighing 130\u2013180\u00a0g and 210\u2013220\u00a0g, were obtained from Experimental Animal Center, Kunming Medical College. The animals were housed on a constant 12-h light/12-dark cycle in our temperature-controlled central animal facility (18\u201322\u00a0\u00b0C) and allowed free access to solid food and tap water. All procedures were in accordance with the Institute Ethical Committee for Experimental Use of Animals. 2.3 Preparation of isolated rat adipocytes Rat adipocytes were isolated by a modification of Rodbell's procedure [14] . Briefly, epididymal fat pads, excised from male Sprague\u2013Dawley rats (weighing 130\u2013180\u00a0g) anesthetized with ether, were cut into the appropriate pieces and were incubated with type II collagenase in Krebs Ringer Bicarbonate (KRB) buffer (120\u00a0mmol/l NaCl, 1.27\u00a0mmol/l CaCl 2 , 1.2\u00a0mmol/l MgSO 4 , 4.75\u00a0mmol/l KCl, 1.2\u00a0mmol/l KH 2 PO 4 and 24\u00a0mmol/l NaHCO 3 : pH 7.4) containing 2% BSA at 37\u00a0\u00b0C with gentle shaking at 70\u00a0cycles/min for 1\u00a0h. At the end of the incubation, the prepared cells were filtered through nylon gauze and washed three times with KRB buffer without collagenase. The cells were counted in a hemacytometer and were prepared for 2.5 \u00d7 10 6 \u00a0cell/ml. Cell preparations showed > 95% viability by trypan blue exclusion. 2.4 FFA release in isolated rat adipocytes Isolated rat adipocytes cells (2.5 \u00d7 10 6 cells/ml) were pre-incubated at 37\u00a0\u00b0C for 30\u00a0min with various concentrations of vanadyl compounds (0.2\u20132\u00a0mmol/l) or insulin (10\u2013160\u00a0nmol/l) in KRB buffer containing 5.0\u00a0mmol/l glucose. Epinephrine (10\u00a0\u03bcmol/l) or forskolin (25\u00a0\u03bcmol/l) was then added to the reaction mixtures, and the resulting solutions were incubated at 37\u00a0\u00b0C for 3\u00a0h. The reactions were stopped by soaking the tube in ice water, and the resulting mixtures were centrifuged at 3500\u00a0rpm for 10\u00a0min at 4\u00a0\u00b0C. For the outer solution of cells, FFA concentrations were determined with a FFA kit. 2.5 Experimental induction of diabetes in rats The model of type 2-like diabetes was prepared as previously described [13] . Briefly, rats with weighing 210\u2013220\u00a0g were intragastrically fed either vehicle (10% Tween-80 and 10% propylene glycol) or high-fat emulsion consisting of 15% lard, 30% sucrose, 10% Tween-80 and 10% propylene glycol in a volume of 20\u00a0ml/kg body weight once a day at 15:00, for 4\u00a0weeks. After an overnight fast, animals were injected intraperitoneally with STZ (25\u00a0mg/kg) dissolved in 0.1\u00a0mol/l citrate buffer (pH 4.4) or citrate buffer. Before injection and on 7th day after injection, blood samples were obtained from the tail vein for assay of blood glucose by the glucose oxidase method using commercially available kits. The fat-fed/STZ-rats with blood glucose concentrations > 11.1\u00a0mmol/l were chosen for experiment. 2.6 Experimental procedure Rats were divided into 6 groups of 10 rats according to the blood glucose concentration: Group 1, normal control rats (0.9% saline-treated); Group 2, fat-fed/STZ-diabetic rats (0.9% saline-treated); Group 3\u20135, fat-fed/STZ-rats treated with BFOV at a dose of 0.02, 0.06, 0.2\u00a0mmol/kg, respectively; Group 6, fat-fed/STZ-rats treated with 0.06\u00a0mmol/kg vanadyl sulfate. All the substances above were administered intragastrically twice a day at 9:00 and 16:00, for 4\u00a0weeks. During experimental period, blood glucose concentrations, body weight gain and food intake were monitored weekly. At the end of experiment, the rats were deprived of food overnight, and blood samples were collected from the femoral artery of rats for determination of serum cholesterol, triglycerides, FFA and leptin concentrations using commercially available kits. 2.7 Statistical analyses Data are expressed as means \u00b1 standard error (S.E.). Statistical analysis was performed by one-way analysis of variance followed by Dunnett's and Bonfferoni's multiple comparison tests using Prism ver. 4.0 software. Statistical significance was accepted at the concentration of P < 0.05. 3 Results The inhibitory activities of vanadyl complexes on FFA release from isolated rat adipocytes treated with epinephrine are shown in Fig. 2 . FFA release from isolated rat adipocytes was significantly stimulated by epinephrine, compared with control group that was cell only ( P < 0.05). Both BFOV and vanadyl sulfate markedly inhibited FFA release from isolated rat adipocytes treated with epinephrine in a concentration-dependent manner. The IC 50 value was found to be 0.30 \u00b1 0.20 and 0.46 \u00b1 0.26\u00a0mmol/l, respectively. But insulin did not antagonize lipolysis triggered by epinephrine. As shown in Fig. 3 , FFA release from adipocytes was significantly stimulated by forskolin, compared with control group ( P < 0.05). While neither BFOV nor vanadyl sulfate suppressed FFA release triggered by forskolin from isolated rat adipocytes. The changes in the concentration of serum lipids of different experimental groups are illustrated in Table 1 , from which it can be seen that the fat-fed/STZ-induced diabetic rats exhibited a significant increase of triglyceride and FFA concentrations. The administration of BFOV to diabetic rats for 4\u00a0weeks resulted in the decrease of triglyceride and FFA concentrations in a dose-dependent manner, when compared to untreated diabetic rats ( P < 0.05). No significant alterations were observed in serum cholesterol of experimental rats. The changes in the serum leptin, food intake, body weight and fasting blood glucose concentrations of the control and experimental rats were represented in Fig. 4 . There was a significant increase of the blood glucose, serum leptin, and food consumption, as well as a decrease of the body weight gain in fat-fed/STZ-diabetic rats. After treatment for 4\u00a0weeks with BFOV the hyperleptinemia, hyperglycemia and the intake of food in diabetic rats were markedly attenuated, while no changes in the body weight gain were observed in comparison with the diabetic rats. Different with BFOV, vanadyl sulfate did not reduce the blood glucose concentration and food intake of diabetic rats. 4 Discussion Prospective epidemiological studies show that an increased FFA concentration is a risk marker for long-term development of glucose intolerance and progression to type 2 diabetes. The increase in plasma FFA concentrations is the result of increased mobilization from adipose tissue. Thus, it is becoming increasingly apparent that reducing FFA release is an important goal in the management of patients with type 2 diabetes. In the present investigation, the antilipolytic action of BFOV was observed by the inhibition of FFA release from isolated rat adipocytes treated with epinephrine and forskolin. When epinephrine binds to the \u03b2-adrenoceptor of adipocytes, the adenylate cyclase is activated to transform ATP to cyclic adenosine 3\u2032, 5\u2032-monophosphate (cAMP), which in turn activates some protein kinases and lipases. The activated lipase then hydrolyzes triglycerides to FFA, which will be released from the cells ( Fig. 5 ) [15] . When vanadate compounds were added to the system, the concentration of FFA was significantly decreased in a concentration-dependent manner, exhibiting that both vanadyl ion (vanadyle sulfate) and vanadyl complex (BFOV) inhibited FFA release from rat adipocytes treated with epinephrine. Interestingly, in the system, insulin did not antagonize epinephrine triggered lipolysis, which was consistent with the results reported by Li [16] . The findings suggested that BFOV has inhibitory effect of lipolysis mediated by superphysiological concentration of catecholamines, and the mechanism is different from that of insulin. As shown in Fig. 5 , insulin binds to the \u03b1-subunit of the insulin receptor and catalyzes autophosphorylation, which in turn stimulates tyrosine kinase in the \u03b2-subunit of insulin receptor. The insulin receptor tyrosine kinase then phosphorylates the insulin receptor substrate (IRS). Following these reactions, signal information is conveyed to downstream locations such as PI3-K, and GLUT-4 is then translocated to the surface of the cell membrane. Consequently, glucose uptake is enhanced and FFA release is subsequently inhibited in isolated rat adipocytes [17,18] by phosphorylating (on serine-302) and activating the phosphodiesterase type 3B (PDE3B), leading to a decrease in cAMP concentrations and thereby the inactivation of the cAMP-dependent protein kinase (PKA) [19] . To confirm whether antilipolysis by vanadyl compounds was related to adenylate cyclase, forskolin, an agonist of adenylate cyclase, was taken to disposal adipocytes instead of epinephrine. Forskolin produces a rapid increase in cAMP production through a direct activation, which in turn stimulates FFA release [20] . When vanadyl sulfate or BFOV was added, the inhibitory effect on FFA release induced by forskolin was not observed. It was suggested that the antilipolysis of BFOV was performed not by inhibiting the activity of adenylate cyclase in isolated rat adipocytes. The antilipolytic action seemed to be related to the signal transmission from the \u03b2-adrenoceptor to adenylate cyclase, which needs further identification. The rodent model induced by high-fat chow feeding plus a relatively moderate amount of STZ injection, which simulates the natural history and the metabolic characteristics of patients with type 2 diabetes, has been recognized as type 2 diabetes model [21,22] . In a previous experiment, we reported that BFOV significantly improved the postprandial blood glucose, the glucose intolerance and the hyperinsulinemia, and increased insulin sensitivity index in the fat-fed/STZ-diabetic rats [13] . In the current experiment, administration of BFOV dose-dependently lowered the serum triglyceride and FFA concentrations in the fat-fed/STZ-diabetic rats. This further indicated that BFOV could decrease FFA release in vivo. It is believed that the decreased FFA flux to the liver prevents FFA uptake by the liver and thus reduces very low density lipoprotein (VLDL) hyperproduction in the liver, which will decrease the plasma triglyceride observed under treatment with BFOV. Further research needs to be done for more evidence. Recent advances in molecular and cell biology have shown that the adipose tissue not only stores excess energy in the form of fat but also secretes biologically active substances called adipocytokines, such as FFA, tumour necrosis factor-\u03b1 (TNF-\u03b1), resistin and adiponectin [23] . Leptin, which is primarily synthesized and secreted from the adipose tissue, is a hormonal protein that controls the overall energy homeostasis via induction of reduced food intake and promotion of fat loss [24] . This adipocytokine has been shown to strongly relate to the developing type 2 diabetes [24] . In human type 2 diabetes, the circulating concentrations of leptin are usually increased accompanied by a reduction in leptin sensitivity (leptin resistance) [25] . Hyperleptinemia was observed in fat-fed/STZ-induced diabetic rats in our experiment, suggesting a state of \u2018leptin resistance\u2019. BFOV reduced the high serum leptin concentration in the diabetic rats, indicating the enhancement of leptin sensitivity. The improved leptin sensitivity suppressed the excessive food intake without affecting the body weight change. The leptin signal is thought to be predominately transferred by the stimulation of Jannus kinase/signal transducer and activator of transcription (JAK/STAT) signal transduction cascade via the binding of leptin to a receptor [26] . The transient characteristic of tyrosine phosphorylation of JAK2 and STAT3 suggests that PTPs are involved in the negative regulation of this signaling pathway. Therefore, it has been suggested that PTP1B might be a key regulator of not only insulin signalling but also leptin signalling [27] . Vanadium compounds have been considered to enhance insulin sensitivity and glucose uptake by inhibiting the PTP1B activity in type 2 diabetic animals [28] . It is worth further studying whether BFOV increases leptin sensitivity by affecting leptin signaling as a PTP1B inhibitor. In conclusion, BFOV complex optimized glucose utilization and reduced mobilization of fat depots, and in turn decreased hyperlipidemia. The antilipolytic action of BFOV was distinct from that of insulin, and was also not related to inhibiting the activity of adenylate cyclase. Acknowledgments This work was supported by National Natural Science Foundation of China (30260118), Yunnan Personal Cultivation Foundation (2004PY01) and Development Grant of Kunming Medical College (KMC 2005 DG 04). References [1] T. O'Brien T.T. Nguyeen B.R. Zimmerman Hyperlipidaemia and diabetes mellitus Mayo Clin Proc 73 1998 969 976 [2] K.N. Frayn Adipose tissue as a buffer for daily lipid flux Diabetologia 45 2002 1201 1210 [3] G. Boden Role of fatty acids in the pathogenesis of insulin resistance and NIDDM Diabetes 46 1997 3 10 [4] J.K. Kim J.J. Fillmore Y. Chen C. Yu I.K. Moore M. Pypaert Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance Proc Natl Acad Sci 98 2001 7522 7527 [5] V. Large P. Arner Regulation of lipolysis in humans. Pathophysiological modulation in obesity, diabetes and hyperlipidemia Diabetes Metab 24 1998 409 418 [6] J.D. McGarry What if Minkowski had been ageusic? An alternative angle on diabetes Science 258 1992 766 770 [7] T. Scior A. Guevara-Garcia P. Bernard Q.T. Do D. Domeyer S. Laufer Are vanadium compounds drugable? Structure and effects of antidiabetic vanadium compounds: a critical review Mini Rev Med Chem 5 2005 995 1008 [8] D. Rehder Biological and medical aspects of vanadium Inorg Chem Commun 6 2003 604 617 [9] A.K. Srivastava M.Z. Mehdi Insulino-mimetic and anti-diabetic effects of vanadium compounds Diabet Med 22 2005 2 13 [10] M.J. Xie W.P. Liu L. Li Z.H. Chen Synthesis and anti-diabetic activity of bis(\u03b1-furancarboxylato)oxovanadium(IV) Acta Chimi Sin 60 2002 892 896 [11] M.J. Xie L.H. Gao L. Li W.P. Liu S.Y. Yan A new orally active antidiabetic vanadyl complex \u2014 bis(\u03b1-furancarboxylato)oxovanadium(IV) J Inorg Biochem 99 2005 546 551 [12] L.H. Gao W.P. Liu B.L. Wang L. Li M.J. Xie Y.R. Li Effects of bis(alpha-furancarboxylato)oxovanadium(IV) on non-diabetic and streptozotocin-diabetic rats Clin Chim Acta 368 2006 173 178 [13] Y.F. Niu W.P. Liu C.F. Tian M.J. Xie L.H. Gao Z.H. Chen Effects of bis(\u03b1-furancarboxylato)oxovanadium(IV) on glucose metabolism in fat-fed/streptozotocin diabetic rats Eur J Pharmacol 572 2007 213 219 [14] M. Rodbell Metabolism of isolated fat cells-I. Effects of hormones on glucose metabolism and lipolysis J Biol Chem 239 1964 375 380 [15] H. Sakurai A new concept: the use of vanadium complexes in the treatment of diabetes mellitus Chem Rec 2 2002 237 248 [16] J. Li G. Elberg N. Sekar Z.B.. He Y. Shechter Antilipolytic actions of vanadate and insulin in rat adipocytes mediated by distinctly different mechanisms Endocrinology 138 1997 2274 2279 [17] H. Sakurai H. Yasui Y. Adachi The therapeutic potential of insulin-mimetic vanadium complexes Expert Opin Investig Drugs 12 2003 1189 1203 [18] A.R. Saltiel C.R. Kahn Insulin signalling and the regulation of glucose and lipid metabolism Nature 414 2001 799 806 [19] E. Degerman P. Belfrage V.C. Manganiello Structure, localization, and regulation of cGMP-inhibited phosphodiesterase (PDE3) J Biol Chem 272 1997 6823 6826 [20] I. Litosch T.H. Hudson I. Mills S.Y.. Li J.N. Fain Forskolin as an activator of cyclic AMP accumulation and lipolysis in rat adipocytes Mol Pharmacol 22 1982 109 115 [21] M.J. Reed K. Meszaros L.J. Entes M.D. Claypool J.G. Pinkett T.M. Gadbois A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat Metabolism 11 2000 1390 1394 [22] E.W. Kraegen P.W. Clark A.B. Jenkins Development of muscle insulin resistance after liver insulin resistance in high-fat-fed rats Diabetes 40 1991 1397 1403 [23] Y. Matsuzawa T. Funahashi T. Nakamura Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances Ann NY Acad Sci 892 1999 146 154 [24] R.B. Ceddia H.A. Koistinen J.R. Zierath G. Sweeney Analysis of paradoxical observations on the association between leptin and insulin resistance FASEB J 16 2002 1163 1176 [25] K. El-Haschimi D.D. Pierroz S.M. Hileman C. Bjorbaek J.S. Flier Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity J Clin Invest 105 2000 1827 1832 [26] C. Kloek A.K. Haq S.L. Dunn H.J. Lavery A.S. Banks M.G. Jr. Myers Regulation of Jak kinases by intracellular leptin receptor sequences J Biol Chem 277 2002 41547 41555 [27] I.K. Lund J.A. Hansen H.S. Andersen N.P. Moller N. Billestrup Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signaling J Mol Endocrinol 34 2005 339 351 [28] C.L. Winter J.S. Lange M.G. Davis G.S. Gerwe T.R. Downs K.G. Peters A nonspecific phosphotyrosine phosphatase inhibitor, bis(maltolato)oxovanadium(IV), improves glucose tolerance and prevents diabetes in Zucker diabetic fatty rats Exp Biol Med 230 2005 207 216",
        "keywords": [
            "adipocyte",
            "bis(\u03b1-furancarboxylato)oxovanadium(iv)",
            "fat-fed/streptozotocin rats",
            "lipid",
            "lipolysis",
            "lipid metabolism"
        ],
        "authors": [
            {
                "name": "Lihui Gao",
                "org": "Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming, PR China"
            },
            {
                "name": "Yanfen Niu",
                "org": "Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming, PR China"
            },
            {
                "name": "Weiping Liu",
                "org": "Kunming Institute of Precious Metals, Kunming, PR China"
            },
            {
                "name": "Mingjin Xie",
                "org": "Department of Chemistry, Yunnan University, Kunming, PR China"
            },
            {
                "name": "Xu Liu",
                "org": "Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming, PR China"
            },
            {
                "name": "Zhihe Chen",
                "org": "Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming, PR China"
            },
            {
                "name": "Ling Li",
                "org": ""
            }
        ],
        "venue": "Clinica Chimica Acta",
        "year": 2008
    },
    "sdSMgtJn": {
        "id": "sdSMgtJn",
        "title": "Investigation on pharmacokinetics, tissue distribution and excretion of a novel anticancer platinum compound by inductively coupled plasma mass spectrometry after intravenous administration to rats.",
        "abstract": "SM54111 [cis-3, 5-diisopropylsalylic cyclohexanodiaminoplatinum (II), Saliplatin] is a novel platinum compound with encouraging anticancer effect. In order to get more useful information in multiple species for the security evaluation, dosage design, and drug delivery design, its pharmacokinetic behaviors in rats after intravenous administration were investigated in this study. Based on its pharmacokinetics in plasma, the distribution of SM54111 in heart, liver, spleen, lung, kidney, brain, adipose, testicle, or ovaries of rats sampled at 0.5 h, 1 h, and 3 h after intravenous administration were determined utilizing inductively coupled plasma mass spectrometry (ICP-MS). Its amounts in urine and feces were determined at 8 sampling times till 96 h as well. It was proved that SM54111 fitted open two-compartment model in rats, with wide distribution in tissues and slow excretion. Its reasonable pharmacokinetic properties in rats make this novel platinum compound worthy of further research and development.",
        "keywords": [
            "pharmacokinetics",
            "icp-ms",
            "excretion",
            "sm54111",
            "tissue distri- bution",
            "novel antitumor platinum compound",
            "Novel antitumor platinum compound",
            "SM54111",
            "Pharmacokinetics",
            "Tissue distribution",
            "Excretion",
            "ICP-MS"
        ],
        "authors": [
            {
                "name": "Qing-Fei Liu",
                "org": "Tsinghua University School of Medicine Beijing 100084 China"
            },
            {
                "name": "Xue Li",
                "org": "Tsinghua University School of Medicine Beijing 100084 China"
            },
            {
                "name": "Qiang Su",
                "org": "Tsinghua University School of Medicine Beijing 100084 China"
            },
            {
                "name": "Guo-An Luo",
                "org": "Tsinghua University School of Medicine Beijing 100084 China"
            },
            {
                "name": "Yi-Ming Wang",
                "org": "Tsinghua University School of Medicine Beijing 100084 China"
            },
            {
                "name": "Wei-Ping Liu",
                "org": "Kunming Institute of Precious Metal Kunming 650221 China"
            }
        ],
        "venue": "Archives of pharmacal research",
        "year": 2009
    },
    "34Jq5bPm": {
        "id": "34Jq5bPm",
        "title": "Antitumor activity of the Carboplatin-\ufffd\ufffd-cyclodextrin adduct",
        "abstract": "Antitumor activity of the adduct between Carboplatin and \ufffd\ufffd-cyclodextrin has been tested against Sarcoma 180 (S180) and Ehrlich ascites carcinoma (EAC) murine tumors. The preliminary toxicity has also been evaluated by histological examinations of the treated animals. The results show the adduct has less antitumor efficacy than and similar toxicity to Carboplatin.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Huizhou Xiong",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Yikun Yang",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Ng Li",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "ZhiQiang Shen",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "ZhiHe Chen",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            }
        ],
        "venue": "Metal-Based Drugs",
        "year": 1997
    },
    "QCypfbqA": {
        "id": "QCypfbqA",
        "title": "A new orally active antidiabetic vanadyl complex \u2013 bis(\u03b1-furancarboxylato)oxovanadium(IV)",
        "abstract": "Bis(\u03b1-furancarboxylato)oxovanadium(IV) \u2013 a new orally active antidiabetic vanadyl complex has been synthesized, characterized, and tested for bioactivity as insulin-enhancing agents. The complex was administered intragastrically to both normal and STZ-diabetic rats for 4 weeks. The results show that the complex at a dose of 10.0 and 20.0 mg V kg \u22121 , could significantly lower the blood glucose level rats and ameliorated impaired glucose tolerance in STZ-diabetic, but not in normal rats. It was suggested that the complex exerted an antidiabetic effect in STZ-diabetic rats, which maybe was related to increasing the sensitivity to insulin. Keywords Oxovanadium \u03b1-Furancarboxylic acid Insulinomimetic activity",
        "keywords": [
            "\u03b1-furancarboxylic acid",
            "insulinomimetic activity",
            "oxovanadium"
        ],
        "authors": [
            {
                "name": "Mingjin Xie",
                "org": ""
            },
            {
                "name": "Lihui Gao",
                "org": "Yunnan Pharmacological Laboratories of Natural products, Kunming Medical College, Kunming 650031, PR China"
            },
            {
                "name": "Ling Li",
                "org": "Yunnan Pharmacological Laboratories of Natural products, Kunming Medical College, Kunming 650031, PR China"
            },
            {
                "name": "Weiping Liu",
                "org": "Kunming Institute of Precious Metals, Kunming 650221, PR China"
            },
            {
                "name": "Shiping Yan",
                "org": ""
            }
        ],
        "venue": "Journal of Inorganic Biochemistry",
        "year": 2005
    },
    "gd3EiSsE": {
        "id": "gd3EiSsE",
        "title": "Insulino-mimetic effects of bis (alpha-furancarboxylato) oxovanadium (IV) in vitro]",
        "abstract": "To study insulino-mimetic effects of bis(alpha-furancarboxylato) oxovanadium (IV) (BFOV), a orally active antidiabetic vanadyl complex, on glucose uptake and lipogenesis in isolated rat adipocytes were determined by using 2-deoxy-D-[3H]-glucose and D-[3H]-glucose, respectively. Lipolysis was assayed by free fatty acids (FFA) released from isolated rat adipocytes treated with epinephrine. The results showed that BFOV, similar to insulin, concentration-dependently significantly enhanced the uptake of 2-deoxy-D-[3H]-glucose and the transformation from D-[3H]-glucose to lipid in isolated rat adipocytes, with the EC50 values of (0.31 +/- 0.08) mmol L(-1) and (0.49 +/- 0.12) mmol L(-1), respectively. Moreover, BFOV markedly inhibited FFA release from isolated rat adipocytes treated with epinephrine, and the IC50 value was (0.30 +/- 0.20) mmol L(-1). BFOV had insulino-mimetic effects such as enhancing glucose uptake and lipogenesis, as well as inhibiting lipolysis.",
        "keywords": [],
        "authors": [
            {
                "name": "Yan-Rong Li",
                "org": "Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming 650031, China."
            },
            {
                "name": "Li-Hui Gao",
                "org": ""
            },
            {
                "name": "Yan-Lin Ma",
                "org": ""
            },
            {
                "name": "Yan-Fen Niu",
                "org": ""
            },
            {
                "name": "Wei-Ping Liu",
                "org": ""
            },
            {
                "name": "Ling Li",
                "org": ""
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2008
    },
    "5HqtqEU6": {
        "id": "5HqtqEU6",
        "title": "A new insulin-enhancing agent: [N,N'-bis(4-hydroxysalicylidene)-o-phenylene-diamine]oxovanadium(IV) and its permeability and cytotoxicity.",
        "abstract": "A new insulin-enhancing agent: [N,N'-bis(4-hydroxysalicylidene)-o-phenylene-diamine] oxovanadium(IV) (BPOV) was synthesized and characterized by X-ray crystallography. BPOV was administered intragastrically to STZ-diabetic rats for 4 weeks. The results showed that BPOV could significantly decrease the blood glucose level and ameliorated impaired glucose tolerance in STZ-diabetic rats. BPOV has been further tested on insulin, glycogen and serum lipid studies. The results suggested BPOV has glucose-lowering activity in diabetic rats, as well as improved the disorder of lipid metabolism in diabetes. BPOV had permeability above 10(-5) cm s(-1). It was suggested good lipophilic properties. The cytotoxicity of BPOV on Caco-2 cells was measured by MTT assay which suggested BPOV have higher effect on impairment of cellular associated with lower level capacity of cellular accumulation.",
        "keywords": [
            "caco-2 cells",
            "insulin-enhancing",
            "salen-type ligands",
            "serum lipids",
            "lipid metabolism",
            "caco 2 cells",
            "x ray crystallography"
        ],
        "authors": [
            {
                "name": "Ming-jin Xie",
                "org": ""
            },
            {
                "name": "Ling Li",
                "org": ""
            },
            {
                "name": "Xiao-Da Yang",
                "org": ""
            },
            {
                "name": "Wei-ping Liu",
                "org": ""
            },
            {
                "name": "Shi-ping Yan",
                "org": ""
            },
            {
                "name": "Yan-fen Niu",
                "org": ""
            },
            {
                "name": "Zhao-hui Meng",
                "org": ""
            }
        ],
        "venue": "European journal of medicinal chemistry",
        "year": 2010
    },
    "m9wyShWc": {
        "id": "m9wyShWc",
        "title": "Synthesis and structural characterization of novel symmetric homodinuclear iridium acetylacetonate complexes",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "juan yu",
                "org": ""
            },
            {
                "name": "qingsong ye",
                "org": ""
            },
            {
                "name": "jialin chen",
                "org": ""
            },
            {
                "name": "jing jiang",
                "org": ""
            },
            {
                "name": "caixian yan",
                "org": ""
            },
            {
                "name": "qiaowen chang",
                "org": ""
            }
        ],
        "venue": "Research on Chemical Intermediates",
        "year": 2014
    },
    "iVvQ72TB": {
        "id": "iVvQ72TB",
        "title": "Assay of platinum coordination by high performance liquid chromatography",
        "abstract": "Objective:To establish a HPLC method for the assay of platinum,cis-3,5-diisoprop- ylsalylic cyclohexanodiaminoplatinum(\u2161) (LSPt-DACH) associated with the determination of water-oil partition coefficient (log P).Methods:The assay was conducted by a HPLC consisted of a Kromasil C_(18) column (250 mm\u00d74.6 mm,5\u03bcm) with a column temperature at 28\u2103,an eluate of methanol-10 mmol\u00b7L~(-1) ammonium acetate solution (70:30) with a flow rate of 1.0 mL\u00b7min~(-1) and a detection wave- length at 315nm.Results:The calibrated linear curve of platinum coordination concentration was within 0.05\uff5e0.60\u03bcg with correlation efficient r=0.9999 and the correlation of y=7109.7x+1387.8.The log P of this platinum coordination was determined as 2.72.Conclusion:This sensitive and reliable HPLC method was useful for quantification of LSPt-DACH.",
        "keywords": [
            "platinum coordination",
            "high performance liquid chromatography (HPLC)",
            "water-oil partition coefficient"
        ],
        "authors": [
            {
                "name": "SU Qiang",
                "org": " Department of Pharmacy,Shenyang Pharmaceutical University,Shenyang ,China; School of Medicine,Tsinghua University,Beijing ,China"
            },
            {
                "name": "LIU Qing-fei",
                "org": " School of Medicine,Tsinghua University,Beijing ,China"
            },
            {
                "name": "YU Yao",
                "org": " Kunming Institute of Precious Metal,Kunming ,China"
            },
            {
                "name": "WANG Yi-ming",
                "org": " School of Medicine,Tsinghua University,Beijing ,China"
            },
            {
                "name": "BI Kai-shun",
                "org": " Department of Pharmacy,Shenyang Pharmaceutical University,Shenyang ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": " Kunming Institute of Precious Metal,Kunming ,China"
            },
            {
                "name": "LUO Guo-an",
                "org": " School of Medicine,Tsinghua University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of New Drugs",
        "year": 2007
    },
    "WigNlQL7": {
        "id": "WigNlQL7",
        "title": "Design, synthesis and anticancer activity of diam(m)ine platinum(II) complexes bearing a small-molecular cell apoptosis inducer dichloroacetate.",
        "abstract": "Four new diam(m)ine platinum complexes containing the dichloroacetate moiety in 3-dichoroacetoxylcyclobutane-1,1-dicarboxylate as the leaving group were synthesized, characterized by elemental analysis as well as by ESI(+)-MS (electrospray ionization mass spectrometry in positive mode), FT-IR, (1)H- and (13)C-NMR, and evaluated for their in vitro anticancer activity against human lung cancer cell line (A549) and ovarian cancer cell lines (SK-OV-3, SK-OV-3/DDP). Diam(m)ines used in the present study belong to the carriers of six clinically approved platinum drugs. Among the complexes synthesized, complex 2, cis-[Pt(II)(1R,2R-diaminocyclohexane)\u00b7(3-dichoroacetoxylcyclobutane-1,1-dicarboxylate)] is the most promising in terms of water solubility and potential of being totally devoid of cross-drug resistance with cisplatin. Therefore, complex 2 was selected for the dichloroacetate release test. The test shows dichloroacetate can be efficiently released from complex 2 under physiological conditions via the hydrolysis of an ester bond bridging the dichloroacetate moiety and platinum pharmacophores together. Our study supports the further evaluation of this complex as a drug candidate.",
        "keywords": [
            "anticancer activity",
            "dichloroacetate",
            "drug resistance",
            "platinum complexes"
        ],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "State Key Laboratory for Platinum Group Metals, Kunming Institute of Precious Metals, 650106 Yunnan, PR China."
            },
            {
                "name": "Jing Jiang",
                "org": "State Key Laboratory for Platinum Group Metals, Kunming Institute of Precious Metals, 650106 Yunnan, PR China."
            },
            {
                "name": "Yongping Xu",
                "org": "Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, PR China."
            },
            {
                "name": "Shuqian Hou",
                "org": "State Key Laboratory for Platinum Group Metals, Kunming Institute of Precious Metals, 650106 Yunnan, PR China."
            },
            {
                "name": "Liping Sun",
                "org": "Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, PR China."
            },
            {
                "name": "Qingsong Ye",
                "org": "State Key Laboratory for Platinum Group Metals, Kunming Institute of Precious Metals, 650106 Yunnan, PR China."
            },
            {
                "name": "Liguang Lou",
                "org": "Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, PR China."
            }
        ],
        "venue": "Journal of inorganic biochemistry",
        "year": 2015
    },
    "a7GaTKO3": {
        "id": "a7GaTKO3",
        "title": "Synthesis and in vitro cytotoxicity of cis-[Pt(NH(3))(NH(2)OH)Cl(2)].",
        "abstract": "A novel mixed NH(3)/NH(2)OH platinum(II) complex cis-[Pt(NH(3))(NH(2)OH)Cl(2)] was synthesized and characterized by elemental analysis, FAB-MS, FT-IR and (1)H NMR spectroscopy. This complex was determined to have a good water-solubility and satisfactory stability. The pertinent complex was evaluated for its in vitro cytotoxicity against 3AO, HCT-116, LNcap, A549/ATCC and SGC-7901 human carcinoma cell lines. It shows appreciable cytotoxic activity that is comparable with cisplatin and is much more active than carboplatin.",
        "keywords": [
            "Platinum",
            " Hydroxylamine",
            " Synthesis",
            " Antitumor"
        ],
        "authors": [
            {
                "name": "Qing-Song Ye",
                "org": "Kunming Institute of Precious Metals, 650106, Kunming, China."
            },
            {
                "name": "Wei-Ping Liu",
                "org": "State Key Lab of Advanced Technologies for Platinum Metals,Kunming Institute of Precious Metals,Kunming,China"
            },
            {
                "name": "Xi-Zhu Chen",
                "org": "State Key Lab of Advanced Technologies for Platinum Metals,Kunming Institute of Precious Metals,Kunming,China"
            },
            {
                "name": "Yao Yu",
                "org": "State Key Lab of Advanced Technologies for Platinum Metals,Kunming Institute of Precious Metals,Kunming,China"
            },
            {
                "name": "Qiao-Wen Chang",
                "org": "State Key Lab of Advanced Technologies for Platinum Metals,Kunming Institute of Precious Metals,Kunming,China"
            },
            {
                "name": "Shu-Qian Hou",
                "org": "State Key Lab of Advanced Technologies for Platinum Metals,Kunming Institute of Precious Metals,Kunming,China"
            }
        ],
        "venue": "Archives of pharmacal research",
        "year": 2010
    },
    "HoHUmqVC": {
        "id": "HoHUmqVC",
        "title": "Effect of Pretreatment of Activated Carbon on the Catalytic Activity of Rh/C",
        "abstract": "The untreated activated carbon was compared with the treated activated carbon by nitric acid and high temperature.The change of carbon surface groups,surface area,pore volume and pore size were measured by IR,adsorption and desorption of nitrogen.Three different catalysts were characterized by XRD,SEM and TPR.The catalytic activity was detected by the hydrogenation of p-chloronitrobenzene to prepare p-chloroaniline.The results show that after heat treatment the surface area and the pore volume of activated carbon increased,the surface groups were changed and the catalytic activity was improved.",
        "keywords": [
            "pretreatment",
            "activated carbon",
            "p-chloronitrobenzene",
            "physical chemistry",
            "hydrogenation",
            "Rh/C"
        ],
        "authors": [
            {
                "name": "WANG Fu",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals,Kunming Institute of Precious Metals,Kunming ,China;Faculty of Chemical Engineering,Kunming University of Science and Technology,Kunming ,China"
            },
            {
                "name": "YE Qingsong",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals,Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "LIU Weiping",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals,Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "WANG Yaming",
                "org": "Faculty of Chemical Engineering,Kunming University of Science and Technology,Kunming ,China"
            },
            {
                "name": "ZHAO Yunkun",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals,Kunming Institute of Precious Metals,Kunming ,China;Kunming Sino-Platinum Metals Catalyst Co.Ltd.,Kunming ,China"
            }
        ],
        "venue": "Precious Metals",
        "year": 2011
    },
    "vG0IcYqK": {
        "id": "vG0IcYqK",
        "title": "Synthesis,Characterization and Thermal Chemical Properties of Rhodium-Phosphine Complexes for Hydroformylation of Alkenes",
        "abstract": "Carbonylhydridotris(triphenylphosphine)rhodium(\u2160)[HRh(CO)(PPh3)3],trans chlorocarbonylbis(triphenylphosphine)rhodium(\u2160) [trans-RhCl(CO)(PPh3)2] are widely used as the catalysts for hydroformylation of alkenes.In this paper,these two compounds were synthesized by improved methods and their yields were higher than that reported in the literatures.The chemical structures of these complexes were determined by elemental analysis,MS,IR and 1H-NMR.The thermal chemical properties were studied via TG-DTA.",
        "keywords": [
            "rhodium-phosphine complexes",
            "thermal chemical properties",
            "hydroformylation of alkenes",
            "structure characterization",
            "physical chemistry",
            "synthesis"
        ],
        "authors": [
            {
                "name": "ZHANG Jun",
                "org": "Kunming Institute of Precious Metals,Sino-platinum Metals Co.Ltd.,Kunming ,Yunnan,China"
            },
            {
                "name": "YU Yao",
                "org": "Kunming Institute of Precious Metals,Sino-platinum Metals Co.Ltd.,Kunming ,Yunnan,China"
            },
            {
                "name": "YE Qingsong",
                "org": "Kunming Institute of Precious Metals,Sino-platinum Metals Co.Ltd.,Kunming ,Yunnan,China"
            },
            {
                "name": "CHEN Xizhu",
                "org": "Kunming Institute of Precious Metals,Sino-platinum Metals Co.Ltd.,Kunming ,Yunnan,China"
            },
            {
                "name": "CHANG Qiaowen",
                "org": "Kunming Institute of Precious Metals,Sino-platinum Metals Co.Ltd.,Kunming ,Yunnan,China"
            },
            {
                "name": "LIU Weiping",
                "org": "Kunming Institute of Precious Metals,Sino-platinum Metals Co.Ltd.,Kunming ,Yunnan,China"
            }
        ],
        "venue": "Precious Metals",
        "year": 2010
    },
    "IEktWsOm": {
        "id": "IEktWsOm",
        "title": "Effects of copper-aspirin complex on plasma 6-keto-prostaglandin F(1\u03b1) level and platelet cytosolic calcium in rabbits",
        "abstract": "Effects of copper-aspirin complex on washed platelet aggregation, thromboxane B(2) formation and 6-ketoprostaglandin F(1alpha) level were monitored by Born's and Terashita's methods, respectively. The influence of copper-aspirin complex on cytosolic free calcium was examined using the fluorescent indicator, Fura 2-AM. Copper-aspirin complex significantly inhibited arachidonic acid-induced aggregation in washed platelets. The IC(50) value was 9.6 micromol L(-1). Copper-aspirin complex significantly decreased arachidonic acid-induced thromboxane B(2) formation by 87.1% in washed platelets. Ten mg kg(-1) of copper-aspirin complex given intragastrically markedly increased the plasma level of 6-keto-prostaglandin F(1alpha). Aspirin, however, reduced both thromboxane B(2) formation and 6-keto-prostaglandin F(1alpha) level. In the presence of CaCl2 1 mmol L(-1), copper-aspirin complex (20, 40 and 80 micromol L(-1)) markedly lowered arachidonic acid-induced increase in platelet calcium from the resting level (270+/-36 nmol L(-1)) to 213+/-14, 170+/-20 and 135+/-17 nmol L(-1), respectively. In the presence of ethylene glycol-bis (beta-aminoethyl ether) N,N,N',N'-tetraacetic acid 1 mmol L(-1), copper-aspirin complex (20, 40 and 80 micromol l L(-1)) significantly suppressed the release of intracellular calcium induced by arachidonic acid from 127+/-23 nmol L-1 to 108+/-17, 93+/-12 and 70+/-13 nmol L(-1).",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "ZhiQiang Shen",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "Ling Li",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "Lanou Wu",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "ZhiHe Chen",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            }
        ],
        "venue": "Platelets",
        "year": 1999
    },
    "8oaUs4sH": {
        "id": "8oaUs4sH",
        "title": "Bis(acetyl-acetonato-2 O,O\u2032)-aqua-(diacetyl-methanido-C) iridium(III)",
        "abstract": "In the crystal structure of the title compound, [Ir(C(5)H(7)O(2))(3)(H(2)O)], the Ir(III) atom is six-coordinated and situated in a slightly distorted octa-hedral environment. The complex contains both Ir-O and Ir-C bonds and was isolated from a reaction mixture of IrCl(3)(H(2)O)(x), pentane-2,5-dione and NaHCO(3). O-H\u22efO hydrogen bonding between the water molecules and the carbonyl O atoms of adjacent molecules leads to a layered motif extending parallel to (010).",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Qiao-Wen Chang",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Ming-Jin Xie",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            },
            {
                "name": "Wei-Ping Liu",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Xi-Zhu Chen",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Qing-Song Ye",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            }
        ],
        "venue": "Acta crystallographica. Section E, Structure reports online",
        "year": 2009
    },
    "RLmFluB5": {
        "id": "RLmFluB5",
        "title": "Insulin-enhancing activity of a dinuclear vanadium complex: 5-chloro-salicylaldhyde ethylenediamine oxovanadium(V) and its permeability and cytotoxicity.",
        "abstract": "A new insulin-enhancing oxovanadium complex 5-chloro-salicylaldhyde ethylenediamine oxovanadium (V) ([V(2)O(2)(mu-O)(2)L(2)]) has been synthesized. The complex was characterized by a variety of physical methods, including X-ray crystallography. The X-ray diffraction analysis show a dinuclear complex of two six-coordinate vanadium centers doubly bridged by the oxygen atoms of the Schiff base ligand with a V(2)O(2) diamond core. The complex was administered intragastrically to STZ-diabetic rats for 2 weeks. The biological activity results show that the complex at the dose of 10.0 and 20.0 mg V kg(-1), could significantly decrease the blood glucose level and ameliorate impaired glucose tolerance in STZ-diabetic rats. That results suggested that the complex exerts an antidiabetic effect in STZ-diabetic rats. Furthermore, the complex ([V(2)O(2)(mu-O)(2)L(2)]) had permeability above 10(-5)cm/s. The experimental results suggested that the vanadium complex permeates via a passive diffusion mechanism. It was also suggested the complex with salen-type ligands has good lipophilic properties and better oral administration. The cytotoxicity of the complex ([V(2)O(2)(mu-O)(2)L(2)]) on Caco-2 cells was measured by a decrease of cell viability using the MTT assay suggesting that the chlorine atom at C4 of complex [V(2)O(2)(mu-O)(2)L(2)] increased cytotoxicity for vanadium complexes.",
        "keywords": [
            "anti-diabetic activity",
            "salen-type ligands",
            "substituent effect",
            "cell viability",
            "biological activity",
            "x ray crystallography"
        ],
        "authors": [
            {
                "name": "Ming-jin Xie",
                "org": ""
            },
            {
                "name": "Xiao-da Yang",
                "org": "Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China"
            },
            {
                "name": "Wei-ping Liu",
                "org": "Kunming Institute of Precious Metals, Kunming 650221, China"
            },
            {
                "name": "Shi-ping Yan",
                "org": "Deparment of Chemistry, Nankai University, Tianjin 300071, China"
            },
            {
                "name": "Zhao-hui Meng",
                "org": "Kunming Hospital of Population and Health, Kunming 650204, China"
            }
        ],
        "venue": "Journal of inorganic biochemistry",
        "year": 2010
    },
    "TBZYMRxb": {
        "id": "TBZYMRxb",
        "title": "Current status of liposomal platinum anticancer agents",
        "abstract": "Among several drug delivery systems,liposomal encapsulated anticancer agents repre- sent an advanced and versatile technology.Liposomes have been successfully used as carriers of cytotoxic antitumor agents,such as adriamycin,taxol and platinum,which feature reduction of drug toxicity,esca- lation of the therapeutic indexes as antitumor agents,and avoidance of cisplatin resistance.This review summarizes preclinical and clinical data of liposomal platinum anticancer agents including SPI-077,lip- oplatin and L-NDDP etc.",
        "keywords": [
            "antitumor activity",
            "liposome",
            "platinum anticancer agents"
        ],
        "authors": [
            {
                "name": "YU Yao",
                "org": "Platinum-based Drug Lab.,Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Platinum-based Drug Lab.,Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "GAO Wen-gui",
                "org": "Platinum-based Drug Lab.,Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "CHEN Xi-zhu",
                "org": "Platinum-based Drug Lab.,Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "LIU Yang",
                "org": "Platinum-based Drug Lab.,Kunming Institute of Precious Metals,Kunming ,China"
            }
        ],
        "venue": "Chinese Journal of New Drugs",
        "year": 2007
    },
    "xdnaDA2m": {
        "id": "xdnaDA2m",
        "title": "Aryl(silyl)amino group stabilized hydridosilanediols: synthesis and characterization and use for preparation of alumino(hydrido)siloxanes",
        "abstract": "Aryl(silyl)amino group stabilized hydridosilanediols RSiH(OH)2 (R = N(SiMe2Ph)-2,6-iPr2C6H3 (4), N(SiMe3)-2,6-iPr2C6H3 (5), and N(SiMe2Ph)-2,4,6-Me3C6H2 (6)) were prepared from the controlled hydrolysis of the related RSiHCl2 (1\u20133) each in the presence of aniline as the HCl acceptor. Reactions of 4 with AlMe3, AliBu3, AlH(iBu)2, and AlH3\u00b7NMe3, respectively, yielded alumino(hydrido)siloxanes [2,6-iPr2C6H3N(SiMe2Ph)Si(H)OAlMe(THF)]2 (7), [2,6-iPr2C6H3N(SiMe2Ph)Si(H)OAliBu(THF)]2 (9), [2,6-iPr2C6H3N(SiMe2Ph)Si(H)O2]3[Al(THF)]2 (10), and [2,6-iPr2C6H3N(SiMe2Ph)Si(H)OAlH(THF)]2 (11). The reaction of 5 with AlMe3 gave [2,6-iPr2C6H3N(SiMe3)Si(H)OAlMe(THF)]2 (8), a compound similar to 7. Compounds 1\u201311 are characterized by NMR (1H, 13C, and 29Si) and IR spectroscopy and CHN elemental analysis, of which 6 and 8\u201311 are further studied by X-ray crystallography. Compounds 8\u20139 and 11 feature cyclic structures all with the skeleton core of Si2O4Al2 while compound 10 exhibits a bicyclic structure having a core of Si3O6Al2. Melting point measurements indicated that 4\u20136 are thermally stable bearing the geminal SiH and SiOH groups. Compounds 8\u20139 and 11 are thermally stable as well with the O atom-bridged SiH and AlR (R = Me, iBu, or H) groups.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaoping Wang",
                "org": "State Key Laboratory of Physical Chemistry of Solid Surfaces, National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters, College of Chemistry and Chemical Engineering, Xiamen University,Xiamen,China"
            },
            {
                "name": "Jiancheng Li",
                "org": "State Key Laboratory of Physical Chemistry of Solid Surfaces, National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters, College of Chemistry and Chemical Engineering, Xiamen University,Xiamen,China"
            },
            {
                "name": "Shimin Chen",
                "org": "State Key Laboratory of Physical Chemistry of Solid Surfaces, National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters, College of Chemistry and Chemical Engineering, Xiamen University,Xiamen,China"
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Qingsong Ye",
                "org": ""
            },
            {
                "name": "Hongping Zhu",
                "org": "State Key Laboratory of Physical Chemistry of Solid Surfaces, National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters, College of Chemistry and Chemical Engineering, Xiamen University,Xiamen,China"
            }
        ],
        "venue": "Dalton Transactions",
        "year": 2016
    },
    "Grbypuwh": {
        "id": "Grbypuwh",
        "title": "3-Hydroxycarboplatin, a Simple Carboplatin Derivative 248 Endowed with an Improved Toxicological Profi le",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "kasem k kasem",
                "org": ""
            },
            {
                "name": "david ager",
                "org": ""
            },
            {
                "name": "fabrizio nerozzi",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "xizhu chen",
                "org": ""
            },
            {
                "name": "qingsong ye",
                "org": ""
            },
            {
                "name": "shuqian hou",
                "org": ""
            },
            {
                "name": "liguang lou",
                "org": ""
            },
            {
                "name": "chengying xie",
                "org": ""
            }
        ],
        "venue": "Platinum Metals Review",
        "year": 2012
    },
    "7H5ftCb6": {
        "id": "7H5ftCb6",
        "title": "Spectrophotometric Determination of Chlorotris(triphenyphosphine)rhodium(\u2160)",
        "abstract": "A spectrophotometric method has been established for the determination of chlorotris-(triphenyphosphine)rhodium(\u2160).The detection wavelength was 350 nm and chloroform was chosen as solvent.The linear range of chlorotris(triphenyphosphine)rhodium(\u2160) was found to be 0.03\uff5e0.17 mg/mL(\u03b3= 0.9990),and the average recovery was 99.13% with RSD being 2.0%.The method is simple,sensitive,and accurate and suitable for quick determination of chlorotris(triphenyphosphine)rhodium(\u2160).",
        "keywords": [
            "spectrophotometry",
            "chlorotris(triphenyphosphine)rhodium(\u2160)",
            "determination",
            "analytic chemistry"
        ],
        "authors": [
            {
                "name": "ZHENG Ping",
                "org": ""
            },
            {
                "name": "PAN Zaifu",
                "org": ""
            },
            {
                "name": "JIANG J",
                "org": ""
            },
            {
                "name": "LIU Guihua",
                "org": ""
            },
            {
                "name": "XIE Xiaotian",
                "org": ""
            },
            {
                "name": "LIU Weiping",
                "org": ""
            }
        ],
        "venue": "Precious Metals",
        "year": 2010
    },
    "lGKbsX2u": {
        "id": "lGKbsX2u",
        "title": "Application of HPLC-ESI-MS/MS to the Determination of a Novel Antitumour Platinum Complex",
        "abstract": "A novel platinum complex,named as saliplatin,was designed,synthesized and characterized with element analysis,coupled inductively plasma-mass spectrum,gravitational thermal-differential thermal analysis,ultraviolet-visible absorption spectrum,infrared spectrum,fast atom bombment mass spectrum and 1H NMR,etc.Its purity was investigated and determined.HPLC-ESI-MS was employed to separate the platinum complex and the impurity,and to identify and quantify the latter.It proved that the impurity in this novel compound was 3,5-diisopropylsalycilic acid,a reactant used in the synthesis of the novel platinum complex,identified with ESI-MS.The mass fraction was determined with HPLC as 4.3%,which meant that the purity of this new substance was 95.7%.",
        "keywords": [
            "Antitumour drug",
            "ESI-MS",
            "Platinum complex"
        ],
        "authors": [
            {
                "name": "Qiang Su",
                "org": "Shenyang Pharmaceutical University(Shenyang Pharmaceutical University),Shenyang,China"
            },
            {
                "name": "LIU Qing-Fei",
                "org": "Institute of Life Science and Biomedicine,3.Department of Chemistry,Tsinghua University,Beijing ,China"
            },
            {
                "name": "LIANG Qiong-Lin",
                "org": ""
            },
            {
                "name": "WANG Yi-Ming",
                "org": "Institute of Life Science and Biomedicine,3.Department of Chemistry,Tsinghua University,Beijing ,China"
            },
            {
                "name": "BI Kai-Shun",
                "org": "School of Pharmacy,Shenyang Pharmaceutical University,Shenyang ,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "LUO Guo-An",
                "org": "Institute of Life Science and Biomedicine,3.Department of Chemistry,Tsinghua University,Beijing ,China"
            }
        ],
        "venue": "Chemical Journal of Chinese Universities",
        "year": 2007
    },
    "vvcadoXb": {
        "id": "vvcadoXb",
        "title": "Recovery of Iridium from Organic Wastewater",
        "abstract": "A new process was established to recover iridium from Ir-containing organic wastewater.The process involves 4 steps,as following:(1) destruction of organic substance by aqua regia,transferring iridium into aqueous chloride media;(2) separation of Ir in the form of Ir(OH)3 or Ir(OH)4 from the aqueous by hydrolysis with NaOH;(3) re-dissolution of Ir(OH)3 or Ir(OH)4 in hydrochloride;and(4) purification by crystallization and ion-exchange to obtain chloro-iridic aicd from the solution.Then calcination and hydrogen reduction of chloro-iridic aicd were used to produce metallic iridium.The process was simple,suitable and has high recovery.",
        "keywords": [
            "organic wastewater",
            "metallurgy",
            "recovery",
            "iridium"
        ],
        "authors": [
            {
                "name": "HE Xiaotang",
                "org": "Sino-Platinum Metals Co.Ltd.,Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "LIU Weiping",
                "org": "Sino-Platinum Metals Co.Ltd.,Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "WU Xilong",
                "org": "Sino-Platinum Metals Co.Ltd.,Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "CHANG Qiaowen",
                "org": "Sino-Platinum Metals Co.Ltd.,Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "WANG Huan",
                "org": "Sino-Platinum Metals Co.Ltd.,Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "HAN Shouli",
                "org": "Sino-Platinum Metals Co.Ltd.,Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            }
        ],
        "venue": "Precious Metals",
        "year": 2010
    },
    "9lDjoHEr": {
        "id": "9lDjoHEr",
        "title": "Preparation and purity determination of cisplatin used for a reference standard",
        "abstract": "A new technique was introduced to prepare high-purity cisplatin.The technique involves selective separation of trans-[Pt(NH3)2Cl2]I in DMF with 18-crown-6,followed by re-precipitation of cisplatin with sodium chloride solution.The purity of the product was determined by HPLC and TLC.The results showed that the content of Cisplatin so prepared was greater than 99.5% and single related impurity did not exceed 0.1%,meeting the reqirement as a reference standard.",
        "keywords": [
            "Reference standard",
            "Cisplatin",
            "Analysis",
            "Preparation"
        ],
        "authors": [
            {
                "name": "CHEN Xi-zhu",
                "org": "Kunming Institute of Precious Metals,Kunming "
            },
            {
                "name": "LIU Yang",
                "org": "Kunming Institute of Precious Metals,Kunming "
            },
            {
                "name": "LIU Wei-ping",
                "org": "Kunming Institute of Precious Metals,Kunming "
            }
        ],
        "venue": "Chinese Journal of Analysis Laboratory",
        "year": 2008
    },
    "KKEG5MOr": {
        "id": "KKEG5MOr",
        "title": "Carbazolylphosphines and carbazolylphosphine oxides: facilely synthesized host materials with tunable mobilities and high triplet energy levels for blue phosphorescent OLEDs",
        "abstract": "A high triplet energy level (ET) and balanced carrier mobility are critical factors for host materials in efficient blue phosphorescent organic light-emitting diodes (PHOLEDs). Herein, we report a facile synthesis of four compounds, dicarbazolylphenylphosphine (DCPP), dicarbazolylphenylphosphine oxide (DCPPO), tricarbazolylphosphine (TCP), and tricarbazolylphosphine oxide (TCPO), and their application as host materials in a classic blue phosphorescent emitter bis[2-(4,6-difluorophenyl)pyridinato-C2,N](picolinato)iridium(III) (FIrpic). The four compounds show a high ET of up to 3.0 eV and tunable mobilities. We fabricated four OLEDs with a device structure of ITO/MoO3 (1 nm)/N,N\u2032-dicarbazolyl-3,5-benzene (mCP):MoO3 (20 wt%, 10 nm)/mCP (30 nm)/Host:FIrpic (7 wt%, 20 nm)/1,3,5-tri(m-pyrid-3-yl-phenyl) benzene (TmPyPB, 40 nm)/LiF (1 nm)/Al (100 nm), all of which display maximum external quantum efficiencies (EQEs) exceeding 20%. The DCPPO-based device reaches the highest EQE of 27.5%, the maximum luminance of 14\u2006070 cd m\u22122, and the lowest efficiency roll-off of 22.2% from 1 to 10 mA cm\u22122, which is among the best-performing FIrpic-based PHOLEDs without using any light extraction method.",
        "keywords": "",
        "authors": [
            {
                "name": "Zifeng Zhao",
                "org": "Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University,Beijing 100871,China"
            },
            {
                "name": "Gang Yu",
                "org": "Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University,Beijing 100871,China"
            },
            {
                "name": "Qiaowen Chang",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming 650106,China"
            },
            {
                "name": "Xiaochen Liu",
                "org": "Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University,Beijing 100871,China"
            },
            {
                "name": "Yang Liu",
                "org": ""
            },
            {
                "name": "Liding Wang",
                "org": "Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University,Beijing 100871,China"
            },
            {
                "name": "Zhiwei Liu",
                "org": "Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University,Beijing 100871,China"
            },
            {
                "name": "Zuqiang Bian",
                "org": "Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University,Beijing 100871,China"
            },
            {
                "name": "Weiping Liu",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming 650106,China"
            },
            {
                "name": "Chunhui Huang",
                "org": "Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University,Beijing 100871,China"
            }
        ],
        "venue": "Journal of Materials Chemistry C",
        "year": 2017
    },
    "kHBhAadv": {
        "id": "kHBhAadv",
        "title": "N-Geminal P/Al Lewis Pair-Alkyne Dipolar Cycloaddition to the Zwitterionic C 2 PNAl-Heterocyclopentene.",
        "abstract": "The N-geminal P/Al Lewis pair [PhPN(2,6-PrCH)AlEt] () has been prepared and studied for reaction with a series of alkynes. The reaction of  with RC\u2261CR yielded zwitterionic CPNAl-heterocyclopentene [Ph PN(2,6-PrCH)AlEt](CR=CR) (R = Me (), Ph ()); with PhC\u2261CEt produced two isomers, [Ph PN(2,6-PrCH)AlEt](CPh=CEt) () and [Ph PN(2,6-PrCH)AlEt](CEt=CPh) (); and with other alkynes generated [Ph PN(2,6-PrCH)AlEt](CR=CR) (R, R = COEt, Ph (); SiMe, Ph (); PPh, Ph (); SiMe,H (); H, EtO ()). Natural bond orbital analysis of the charge separation of the C\u2261C bond of alkynes was carried out, and then, the electronic matching interaction mode between the combined Lewis acid (AlEt) and base (PPh) groups of  and the C\u2261C bond of such alkynes was discussed. Reactions of  with alkene, nitrile, and carbodiimide molecules were also carried out, and cycloaddition compounds - were produced.",
        "keywords": "",
        "authors": [
            {
                "name": "Shuang Ding",
                "org": "State Key Laboratory of Physical Chemistry of Solid Surfaces, National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China."
            },
            {
                "name": "Jiancheng Li",
                "org": "State Key Laboratory of Physical Chemistry of Solid Surfaces, National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China."
            },
            {
                "name": "Rui Liu",
                "org": "State Key Laboratory of Physical Chemistry of Solid Surfaces, National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China."
            },
            {
                "name": "Gang Fu",
                "org": "State Key Laboratory of Physical Chemistry of Solid Surfaces, National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China."
            },
            {
                "name": "Hongping Zhu",
                "org": "State Key Laboratory of Physical Chemistry of Solid Surfaces, National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China."
            },
            {
                "name": "Weiping Liu",
                "org": "State Key Laboratory for Platinum Group Metals, Kunming Institute of Precious Metals, Kunming, Yunnan 650106, China."
            },
            {
                "name": "Qingsong Ye",
                "org": "State Key Laboratory for Platinum Group Metals, Kunming Institute of Precious Metals, Kunming, Yunnan 650106, China."
            }
        ],
        "venue": "ACS omega",
        "year": 2017
    },
    "QoudinHn": {
        "id": "QoudinHn",
        "title": "Enantiomeric separation of organophosphorus pesticides by high-performance liquid chromatography, gas chromatography and capillary electrophoresis and their applications to environmental fate and toxicity assays.",
        "abstract": "In recent years, the continuous evolution of the field of stereochemistry has produced a heightened awareness of the applications of pure enantiomers of agrochemicals. This review describes reports of the enantiomeric separation of commercial organophosphorus pesticides (OPs) and the applications of these methods to research on the enantioselectivity of the toxicity and environmental fate of these compounds. Chiral OPs can be analysed by high-performance liquid chromatography (HPLC), gas chromatography (GC), and capillary electrophoresis (CE). These different separation techniques for OP enantiomers are briefly discussed, and their applications are presented.",
        "keywords": [
            "toxicity",
            "environmental fate",
            "capillary electrophoresis",
            "gas chromatography",
            "organophosphorus pesticides",
            "high-performance liquid chromatography",
            "enantiomeric separation",
            "high performance liquid chromatography"
        ],
        "authors": [
            {
                "name": "Ling Li",
                "org": "Research Center of Green Chirality, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Shanshan Zhou",
                "org": "Research Center of Green Chirality, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Lixia Jin",
                "org": "Research Center of Green Chirality, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Cheng Zhang",
                "org": "Research Center of Green Chirality, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Weiping Liu",
                "org": ""
            }
        ],
        "venue": "Journal of chromatography. B, Analytical technologies in the biomedical and life sciences",
        "year": 2010
    },
    "s0VEhG7a": {
        "id": "s0VEhG7a",
        "title": "Inhibitory effects of copper-aspirin complex on platelet aggregation'",
        "abstract": "AIM: To study the inhibitory effects of copper-aspirin complex (CuAsp) on platelet aggregation. METHODS: With adenosine diphosphate the effects of CuAsp on platelet aggregation in vitro or in vivo were investigated. Radioimmunoassay and fluorophotometry were used to measure thromboxane B2 (TXB2) generation from platelets, the levels of TXB2 and of 6-keto- PGF(1\ufffd\ufffd) in plasma and the platelet serotonin release reaction. RESULTS: In vitro, CuAsp inhibited arachidonic acid (AA)-induced aggregation (IC50 = 17 \ufffd\ufffdmol \ufffd\ufffd L-1 95 % confidence limits: 9 - 33 \ufffd\ufffdmol \ufffd\ufffd L-1), the release of 5-HT (IC50 = 19 \ufffd\ufffdmol \ufffd\ufffd L-1, 95 % confidence limits: 10 - 30 \ufffd\ufffdmol \ufffd\ufffd L-1), and TXB2 generation from platelets (P < 0.05). CuAsp 10 mg \ufffd\ufffd kg- 1 ig selectively inhibited AA-induced aggregation, and increased the 6- keto-PGF(1\ufffd\ufffd) concentration in plasma while decreased that of TXB2. CONCLUSION: CoAsp, in vitro or in vivo, shows more potent inhibitory effects on AA-induced aggregation than aspirin (Asp), related to the inhibition of platelet cyclooxygenase and the release of active substances from platelets.",
        "keywords": [
            "Adenosine diphosphate",
            "Arachidonic acid",
            "Aspirin",
            "Copper",
            "Epoprostenol",
            "Platelet activating factor",
            "Platelet aggregation",
            "Serotonin",
            "Thromboxane A2"
        ],
        "authors": [
            {
                "name": "ZhiQiang Shen",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "ZhiHe Chen",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "Guo Y. Ma",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "Decheng Wang",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "Wanling Wu",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Yikun Yang",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Huizhou Xiong",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            }
        ],
        "venue": "Acta Pharmacologica Sinica",
        "year": 1997
    },
    "qIltnv8Q": {
        "id": "qIltnv8Q",
        "title": "Separation and toxicity of salithion enantiomers.",
        "abstract": "Enantioseletive toxicities of chiral pesticides have become an environmental concern recently. In this study, we evaluated the enantiomeric separation of salithion on a suite of commercial chiral columns and assessed the toxicity of enantiomers toward butyrylcholinesterase and Daphnia magna. Satisfactory separations of salithion enantiomers could be achieved on all tested columns, that is, Chiralcel OD, Chiralcel OJ, and Chiralpak AD column. However, the Chiralpak AD column offered the best separation and was chosen to prepare micro-scale of pure salithion enantiomers for subsequent bioassays. The first and second enantiomers eluted on the Chiralpak AD column were further confirmed to be (-)-S-salithion and (+)-R-salithion, respectively. The half inhibition concentrations to butyrylcholinesterase of racemate, (+)-R-salithion, and (-)-S-salithion were 33.09, 2.92, and 15.60 mg/l, respectively, showing (+)-R-enantiomer being about 5.0 times more potent than its (-)-S-form. However, the median lethal concentrations (96 h) of racemate, (+)-R-salithion, and (-)-S-salithion toward D. magna were 3.54, 1.10, and 0.36 microg/l, respectively, suggesting that (-)-S-salithion was about 3.0 times more toxic than (+)-R-form. Racemic salithion was less toxic than either of the enantiomers in both bioassays, suggesting that antagonistic interactions might occur between the enantiomers during the toxication action. This work reveals that the toxicity of salithion toward butyrylcholinesterase and D. magna is enantioselective, and this factor should be taken into consideration in the environmental risk assessment of salithion.",
        "keywords": [
            "butyrylcholinesterase",
            "daphnia magna",
            "organophosphorus pesticides",
            "enantioselectivity",
            "chiral separation"
        ],
        "authors": [
            {
                "name": "Shanshan Zhou",
                "org": ""
            },
            {
                "name": "Kunde Lin",
                "org": ""
            },
            {
                "name": "Ling Li",
                "org": ""
            },
            {
                "name": "Meiqing Jin",
                "org": ""
            },
            {
                "name": "Jing Ye",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            }
        ],
        "venue": "Chirality",
        "year": 2009
    },
    "YilvJHoA": {
        "id": "YilvJHoA",
        "title": "Preparation and Characterization of cis-and transDichlorobis(diethylsulfide) platinum(\u2161)",
        "abstract": "Two hydrosilylation catalysts,cis-and trans-dichlorobis(diethylsulfide) platinum(\u2161),were synthesized and characterized by MS,FT-IR,1H and 13C NMR spectroscopy.Both complexes could be prepared by the reaction of potassium tetrachloroplatinate(II) with diethyl sulfide.Appropriate amount of diethyl sulfide in the reaction yields the bright yellow trans-dichlorobis(diethylsulfide) platinum(\u2161),while excess amount of diethyl sulfide yields cis-dichlorobis(diethylsulfide) platinum(\u2161).",
        "keywords": [
            "hydrosilylation catalysts",
            "platinum complexes",
            "diethyl sulfide",
            "organic chemistry"
        ],
        "authors": [
            {
                "name": "WANG Jianqing",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China;College of Chemistry and Chemical Engineering, Yunnan Normal University,Kunming ,China"
            },
            {
                "name": "YE Qingsong",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "CHANG Qiaowen",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "CHEN Xizhu",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "XIE Xiaotian",
                "org": "College of Chemistry and Chemical Engineering, Yunnan Normal University,Kunming ,China"
            },
            {
                "name": "LIU Weiping",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            }
        ],
        "venue": "Precious Metals",
        "year": 2012
    },
    "NSiKEvT0": {
        "id": "NSiKEvT0",
        "title": "Modulation effect of bis (alpha-furancarboxylato) oxovanadium (IV) on blood glucose in diabetic rats]",
        "abstract": "To study the hypoglycemic effect of bis (alpha-furancarboxylato) oxovanadium (IV) (VO-FA) in normal rats and streptozotocin (STZ)-diabetic rats.Rats were injected intraperitoneally STZ 50 mg.kg(-1) to induce diabetes. Blood glucose, glycohemoglobin, glycogen and serum insulin were observed after administering intragastrically VO-FA for four weeks.After 2 weeks administration, VO-FA reduced the blood glucose in STZ-rats (P < 0. 01) dose-dependently, and up to 4 weeks the blood glucose was normalized (below 11.1 mmol.L(-1)) in some of STZ-rats, whereas did not decrease in normal rats. After administration of VO-FA at the dosage of 56.8 and 113.6 mg.kg(-1), the serum insulin levels were lowered in normal rats and STZ-rats, respectively. Moreover, VO-FA reduced glycohemoglobin, improved the glucose tolerance, and increased the liver glycogen and muscle glycogen contents in STZ-rats in a dose-dependent manner (P < 0. 05, P < 0. 01), but not in normal rats.VO-FA could improve the glycometabolism in STZ-rats, but not in normal rats.",
        "keywords": [],
        "authors": [
            {
                "name": "Li-Hui Gao",
                "org": "Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming 650031, China."
            },
            {
                "name": "Ming-Jin Xie",
                "org": ""
            },
            {
                "name": "Ling Li",
                "org": ""
            },
            {
                "name": "Wei-Ping Liu",
                "org": ""
            },
            {
                "name": "Yan-Rong Li",
                "org": ""
            },
            {
                "name": "Zhi-He Chen",
                "org": ""
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2005
    },
    "ARqHz5la": {
        "id": "ARqHz5la",
        "title": "Effects of bis(alpha-furancarboxylato)oxovanadium(IV) on glucose metabolism in fat-fed/streptozotocin-diabetic rats.",
        "abstract": "Bis(alpha-furancarboxylato)oxovanadium(IV) (BFOV) is a new orally active anti-diabetic organic vanadium complex. In the previous studies, we found that BFOV exhibited a glucose-lowering activity following oral administration to type 1-like diabetic mice induced by alloxan and rats induced by streptozotocin, and the mechanism was not related to enhancing the insulin synthesis and secretion. Since the enhancement of insulin sensitivity is involved in one of the mechanisms by which vanadium exerts its anti-diabetic effects, BFOV has been further tested on fat-fed/streptozotocin-treated rats, a type 2-like diabetic animal model, in the present study. The results showed that 4 weeks of BFOV treatment significantly improved hyperglycemia, glucose intolerance and hyperinsulinemia, as well as increased insulin sensitivity index in the fat-fed/streptozotocin-diabetic rats. Furthermore, BFOV efficiently activated glucokinase, increased hepatic glycogen content and suppressed phosphoenolpyruvate carboxykinase gene expression in the liver and kidney of the diabetic rats, which contributed to augmentation of hepatic glucose disposal and maintenance of blood glucose homeostasis. These findings suggested that BEOV had anti-diabetic and insulin-sensitizing effects in the diabetic rats, exhibiting the potential to be developed as a new therapeutic agent for the treatment of type 2 diabetes.",
        "keywords": [],
        "authors": [
            {
                "name": "Yanfen Niu",
                "org": "Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming, PR China."
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Changfu Tian",
                "org": ""
            },
            {
                "name": "Mingjin Xie",
                "org": ""
            },
            {
                "name": "Lihui Gao",
                "org": ""
            },
            {
                "name": "Zhihe Chen",
                "org": ""
            },
            {
                "name": "Xizhu Chen",
                "org": ""
            },
            {
                "name": "Ling Li",
                "org": ""
            }
        ],
        "venue": "European journal of pharmacology",
        "year": 2007
    },
    "4KARDrNk": {
        "id": "4KARDrNk",
        "title": "Research Progress of the HPLC Method for Anti-cancer Platinum Complexes",
        "abstract": "Platinum complexes are one of the most effective anti-cancer agents currently used in clinical treatments of cancer patients.The past decade has witnessed rapid developments in this field and some modern chemical analytical methods have also applied to determination of these agents.The methods include residue on ignition method,HPLC,TLC,UV\u2013Vis spectrophotometry and capillary electrophoresis,among which HPLC is the most frequently used because it has many advantages,such as fast analytical speed,high separation efficiency and detection sensitivity,automatic detection and wide-range application.The present paper summarized the HPLC for clinically approved platinum drugs as well as some platinum complexes under clinical investigation.",
        "keywords": [
            "analytical chemistry",
            "HPLC method",
            "platinum anti-cancer complexes",
            "research progress"
        ],
        "authors": [
            {
                "name": "YANG Shuiyan",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China;School of Chemistry and Chemical Engineering,Yunnan Normal University,Kunming ,China"
            },
            {
                "name": "XIE Xiaotian",
                "org": "School of Chemistry and Chemical Engineering,Yunnan Normal University,Kunming ,China"
            },
            {
                "name": "YE Qingsong",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "CHEN Xizhu",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "JIANG Jing",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China;School of Chemistry and Chemical Engineering,Yunnan Normal University,Kunming ,China"
            },
            {
                "name": "LIU Weiping",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            }
        ],
        "venue": "Precious Metals",
        "year": 2011
    },
    "IoOwDjT7": {
        "id": "IoOwDjT7",
        "title": "Research Progress of Ordered Porous Composite Materials Doped by Precious Metals",
        "abstract": "Ordered porous composite materials doped by precious metals are a kind of important supported catalysts.This paper reviewed the ordered porous materials and the precious metal precursors used for preparation of the composite materials.The application and the formation mechanism of ordered porous composite materials doped by precious metals were briefly introduced.",
        "keywords": [
            "progress",
            "catalytic chemistry",
            "precursor",
            "precious metals",
            "ordered porous materials"
        ],
        "authors": [
            {
                "name": "CHANG Qiaowen",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "WU Ling",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "WANG Tongwen",
                "org": "Yunnan Normal University,Kunming,Yunnan ,China"
            },
            {
                "name": "ZHANG Ni",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "YE Qingsong",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "YU Yao",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "CHEN Xizhu",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "LI Chunying",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "LIU Weiping",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            }
        ],
        "venue": "Precious Metals",
        "year": 2009
    },
    "e87icCHW": {
        "id": "e87icCHW",
        "title": "Amino group combined P/Ge and P/Sn Lewis pairs: synthesis and dipolar addition reactions to alkyne and aldehyde molecules",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ying yu",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "jiancheng li",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "qingsong ye",
                "org": ""
            },
            {
                "name": "hongping zhu",
                "org": "uc berkeley college of chemistry"
            }
        ],
        "venue": "Dalton Transactions",
        "year": 2015
    },
    "kUmphXHr": {
        "id": "kUmphXHr",
        "title": "Novel Lipophilic Platinum(II) Compounds of Salicylate Derivatives RESEARCH, DEVELOPMENT AND LIPOSOMAL FORMULATION",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "qingsong ye",
                "org": ""
            },
            {
                "name": "yao yu",
                "org": ""
            },
            {
                "name": "xizhu chen",
                "org": ""
            },
            {
                "name": "shuqian hou",
                "org": ""
            },
            {
                "name": "liguang lou",
                "org": ""
            },
            {
                "name": "yongping yang",
                "org": ""
            },
            {
                "name": "yiming wang",
                "org": ""
            },
            {
                "name": "qiang su",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2008
    },
    "YevfdzDk": {
        "id": "YevfdzDk",
        "title": "Effects of bis(\u03b1-furancarboxylato)oxovanadium(IV) on glucose metabolism in fat-fed/streptozotocin-diabetic rats",
        "abstract": "Bis(\u03b1-furancarboxylato)oxovanadium(IV) (BFOV) is a new orally active anti-diabetic organic vanadium complex. In the previous studies, we found that BFOV exhibited a glucose-lowering activity following oral administration to type 1-like diabetic mice induced by alloxan and rats induced by streptozotocin, and the mechanism was not related to enhancing the insulin synthesis and secretion. Since the enhancement of insulin sensitivity is involved in one of the mechanisms by which vanadium exerts its anti-diabetic effects, BFOV has been further tested on fat-fed/streptozotocin-treated rats, a type 2-like diabetic animal model, in the present study. The results showed that 4\u00a0weeks of BFOV treatment significantly improved hyperglycemia, glucose intolerance and hyperinsulinemia, as well as increased insulin sensitivity index in the fat-fed/streptozotocin-diabetic rats. Furthermore, BFOV efficiently activated glucokinase, increased hepatic glycogen content and suppressed phosphoenolpyruvate carboxykinase gene expression in the liver and kidney of the diabetic rats, which contributed to augmentation of hepatic glucose disposal and maintenance of blood glucose homeostasis. These findings suggested that BEOV had anti-diabetic and insulin-sensitizing effects in the diabetic rats, exhibiting the potential to be developed as a new therapeutic agent for the treatment of type 2 diabetes.",
        "keywords": [
            "fat-fed/streptozotocin rats",
            "glucokinase",
            "blood glucose",
            "bis(\u03b1-furancarboxylato)oxovanadium(iv)",
            "insulin",
            "phosphoenolpyruvate carboxykinase",
            "gene expression",
            "glucose metabolism"
        ],
        "authors": [
            {
                "name": "Yanfen Niu",
                "org": "Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming, PR China"
            },
            {
                "name": "Weiping Liu",
                "org": "Kunming Institute of Precious Metals, Kunming, PR China"
            },
            {
                "name": "Changfu Tian",
                "org": "Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming, PR China"
            },
            {
                "name": "Mingjin Xie",
                "org": "Department of Chemistry, Yunnan University, Kunming, PR China"
            },
            {
                "name": "Lihui Gao",
                "org": "Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming, PR China"
            },
            {
                "name": "Zhihe Chen",
                "org": "Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming, PR China"
            },
            {
                "name": "Xizhu Chen",
                "org": "Kunming Institute of Precious Metals, Kunming, PR China"
            },
            {
                "name": "Ling Li",
                "org": ""
            }
        ],
        "venue": "European Journal of Pharmacology",
        "year": 2007
    },
    "9EzHWQsa": {
        "id": "9EzHWQsa",
        "title": "Crystal structure of bis(acetylacetonato-kappa O-2,O ')-(diacetylmethanido-kappa C)(2-hydroxypyridine)iridium(III), Ir(C5H7O2)(3)(C5H5NO)",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "qiaowen chang",
                "org": ""
            },
            {
                "name": "changyi hu",
                "org": ""
            },
            {
                "name": "jialin chen",
                "org": ""
            },
            {
                "name": "qingsong ye",
                "org": ""
            },
            {
                "name": "strong",
                "org": ""
            },
            {
                "name": "xizhu chen",
                "org": ""
            },
            {
                "name": "yao yu",
                "org": ""
            },
            {
                "name": "liqiao chen",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            }
        ],
        "venue": "Zeitschrift Fur Kristallographie-new Crystal Structures",
        "year": 2011
    },
    "9R7EThro": {
        "id": "9R7EThro",
        "title": "Stereoisomeric separation and bioassay of a new organophosphorus compound, O,S-dimethyl-N-(2,2,2-trichloro-1-methoxyethyl)phosphoramidothioate: some implications for chiral switch.",
        "abstract": "The manufacture and use of single- or enriched-enantiomer pesticides are green-chemistry developments advocated in the 21st century, but predictive work for chiral switch of newly produced chiral active ingredients is limited. In the present study, the stereoselective separation, target activity, and nontarget toxicity of O,S-dimethyl-N-(2,2,2-trichloro-1-methoxyethyl)phosphoramidothioate (MCP), a new organophosphorus compound, were investigated. Because being highly active and safe is a prerequisite for marketing single-isomer products, the above studies were used to offer some implications for the chiral switch of racemic MCP. The results showed that all four stereoisomers of MCP were successfully separated with a Chiralpak AD column on HPLC. The resolved isomers and the pairs of enantiomers were further distinguished using a circular dichroism detector, designating the first and third eluted peaks as one pair of enantiomers and the second and fourth peaks as the other pair. Then, the insecticidal activities and acute and delayed toxicities of the resolved isomers of MCP were evaluated by their acute lethal efficacy against Daphina magna , their inhibitory potentials to acetylcholinesterase (AChE), and axon-like outgrowth of the SH-SY5Y cells, respectively. The inhibition potencies of the isomers against AChE in SH-SY5Y cells were low and slightly stereoselective. On the other hand, a significant difference was observed among the isomers in their activities and delayed neurotoxicities. The 48 h acute toxicities of isomers to D. magna followed the order peak 1 approximately pair 1 (i.e., equimolar mixture of peaks 1 and 3) > peak 4 approximately racemate > pair 2 (i.e., equimolar mixture of peaks 2 and 4) > peak 2 > peak 3, with 1.0-6.3-fold differences among them. In comparison, the inhibitory potentials of the isomers toward axon growth of SH-SY5Y cells decreased in the order peak 2 > pair 2 > peak 4 > racemate > peak 3 > pair 1 approximately peak 1, with at least a 60-fold difference between the strongest and weakest inhibitors. Those results imply that peak 1 has the optimal target selectivity and ecological profile among the four stereoisomers. It was calculated that two-thirds of the usual pesticide usage can be saved concomitantly with a substantial decrease in neuropathic risk if MCP is present only as peak 1 rather than the racemate. When considering the absence of the economically feasible synthetic methods and techniques to produce optically pure isomers of organophosphorus pesticides, pair 1 of MCP shows considerable worth for future applications on the basis of its biological predominance and cost effectiveness.",
        "keywords": [
            "organophosphate-induced delayed neuropathy",
            "acute toxicity",
            "green pesticide",
            "insecticidal activity",
            "human safety",
            "stereoselectivity",
            "aquatic animals",
            "bioassays",
            "toxicity",
            "chemical structure"
        ],
        "authors": [
            {
                "name": "Shanshan Zhou",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Lumei Wang",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Ling Li",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            }
        ],
        "venue": "Journal of agricultural and food chemistry",
        "year": 2009
    },
    "MxTpvvU8": {
        "id": "MxTpvvU8",
        "title": "Study on the Coordinate Mode of Acetylacetonate in Ir(acac)_3 and Ir(acac)_3(H_2O)",
        "abstract": "The coordination pattern between acac-and Ir(III) in the iridium complexes,Ir(acac)3 and Ir(acac)3(H2O),was studied by 13C-NMR,1H-NMR spectroscopy and single crystal X ray diffraction.The results revealed that there are two coordinate modes between acetylacetonate and iridium,which are oxygen bond and carbon bond coordination.",
        "keywords": [
            "iridium complex",
            "coordination chemistry",
            "acetylacetone"
        ],
        "authors": [
            {
                "name": "CHANG Qiaowen",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "CHEN Jialin",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "LIU Weiping",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "YE Qingsong",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "CHEN Xizhu",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "YU Yao",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "CHEN Liqiao",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "HU Changyi",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            }
        ],
        "venue": "Precious Metals",
        "year": 2011
    },
    "tSWSSDVn": {
        "id": "tSWSSDVn",
        "title": "Synthesis and Structural Characterization of Trans-dichlorobis(triphenylphosphine) palladium(\u2161)",
        "abstract": "trans-Dichlorobis(triphenylphosphine)palladium(\u2161),an impotant homogeneous catalyst for C-C formation,hydrogenation and CO addition,was prepared by the reaction of PdCl2 and triphenylphosphine in alcohol as the solvent,and its chemical structure was characterized by elemental analysis,IR,1H and13C-NMR.With a yield up to 98%,synthetic procedure is acceptable with respect to industrial manufacturing.",
        "keywords": [
            "structure",
            "trans-Dichlorobis(triphenylphosphine)palladium(\u2161)",
            "synthesis"
        ],
        "authors": [
            {
                "name": "LIU Gui-hua",
                "org": "Sino-Platinum Corperation"
            },
            {
                "name": "YE Qing-song",
                "org": "Kunming Institute of Precious Metals,State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals,Yunnan,Kunming,,China"
            },
            {
                "name": "PAN Zai-fu",
                "org": "Sino-Platinum Corperation"
            },
            {
                "name": "YU Juan",
                "org": "Kunming Institute of Precious Metals,State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals,Yunnan,Kunming,,China"
            },
            {
                "name": "SHEN Shan-wen",
                "org": "Sino-Platinum Corperation"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Kunming Institute of Precious Metals,State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals,Yunnan,Kunming,,China"
            }
        ],
        "venue": "Yunnan Chemical Technology",
        "year": 2013
    },
    "5D347hTw": {
        "id": "5D347hTw",
        "title": "Effects of bis (\u03b1-furancarboxylato) oxovanadium (IV) on the glucose uptake in normal and insulin-resistant 3T3-L1 adipocytes",
        "abstract": "Aim: To investigate the effects of bis [(\u03b1-furancarboxylato) oxovanadium (IV), BFOV] on the glucose uptake in normal and insulin-resistant 3T3-L1 adipocytes. Method: Fully differentiated 3T3-L1 adipocytes were treated with dexamethasone to induce insulin resistance. Effects of bis (\u03b1-furancarboxylato) oxovanadium (IV) on the glucose uptake in normal and insulin-resistant adipocytes were estimated by the changes of glucose consumption in the medium measured by the glucose oxidase method. Results BFOV (2.5 - 40 \u03bcmol \u00b7 L-1) produced the tendency of increasing the glucose consumption in normal cells, compared with untreated control cells (P > 0.05). However, BFOV markedly enhanced the glucose consumption in insulin-resistant 3T3-L1 adipocytes, resulting in the improvement of insulin resistance induced by dexamethasone. Conclusion: BFOV increased the glucose uptake in insulin-resistant adipocytes, suggesting the improvement of insulin resistance.",
        "keywords": [
            "3T3-L1 adipocytes",
            "Bis (\u03b1-furancarboxylato) oxovanadium (IV)",
            "Dexamethasone",
            "Glucose consumption",
            "Insulin resistance"
        ],
        "authors": [
            {
                "name": "Yi Qing Zuo",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "NIU Yan-fen",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "Hua Lin",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "Fang Wang",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Ling Li",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            }
        ],
        "venue": "Chinese Pharmacological Bulletin",
        "year": 2008
    },
    "Mh7ndSVC": {
        "id": "Mh7ndSVC",
        "title": "(1,3-Diaminopropan-2-ol-\u03ba 2 N , N \u2032)(3-hydroxycyclobutane-1,1-dicarboxylato-\u03ba 2 O , O \u2032)platinum(II) monohydrate",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "mingjin xie",
                "org": ""
            },
            {
                "name": "xizhu chen",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "y s yao",
                "org": ""
            },
            {
                "name": "qingsong ye",
                "org": ""
            }
        ],
        "venue": "Acta Crystallographica Section E-structure Reports Online",
        "year": 2007
    },
    "zjdXEqAm": {
        "id": "zjdXEqAm",
        "title": "Effects of copper-aspirin complex on platelet-neutrophil interactions1",
        "abstract": "AIM: To investigate the effects of copper-aspirin complex on rat thrombosis and the interaction between platelets and neutrophils. METHODS: The model of electrically stimulated carotid artery thrombosis in Sprague Dawley rats was used; the effects of copper-aspirin complex on rat platelet-neutrophil adhesion and platelet aggregation stimulated by activated neutrophils were observed by rosette assay and Born's method, respectively. RESULTS: Intragastric copper-aspirin complex (5, 7, and 10 mg/kg) dose-dependently prolonged the occlusion time; it signifi- cantly decreased the rosette number formed between thrombin-activated platelets and neutrophils; the 50 % of inhibitory concentration (IC50) was (54.6\u00b14.3) \u00b5mol/L. Copper-aspirin complex markedly inhibited rat platelet aggregation induced by either cell free supernatant of activated neutrophils or by activated neutrophil suspension. The values of IC50 were (224.5\u00b116.2) \u00b5mol/L and (820.5\u00b121.4) \u00b5mol/L, whereas aspirin had no influence. CONCLUSION: Copper-aspirin complex inhibited platelet-neutrophil interactions through a different property from aspirin and resulted in a more potent antithrombotic activity.",
        "keywords": [],
        "authors": [
            {
                "name": "ZhiQiang Shen",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "Peng Chen",
                "org": "Kunming Shenghuo Pharmaceut. Ltd Co(Kunming Shenghuo Pharmaceut. Ltd Co,Kunming Jindian Pharmaceutical Co., Ltd.),Kunming,China"
            },
            {
                "name": "Ling Li",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "Peng Chen",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            }
        ],
        "venue": "Acta Pharmacologica Sinica",
        "year": 2004
    },
    "GAt5Iv07": {
        "id": "GAt5Iv07",
        "title": "Application of high performance capillary electrophoresis tandem mass spectrometry to the investigation on the stability of novel anticancer platinum complex in solution",
        "abstract": "The stability of novel anticancer platinum complex in solution, named as cis-3,5-diisopropylsalici-lyco-(lR,2R-cyclodiamino) Pt( II ), or SM 54111 for short, was investigated. The platinum complex was designed, synthesized, and characterized by element analysis, coupled inductively plasma mass spectrometry, gravitational thermal-differential thermal analysis, ultraviolet-visible absorption spectrometry, infrared specos-copy, fast atom bombment mass spectrometry and H nuclear magnetic resonance, etc. High performance capillary electrophoresis-electrospray ionization-mass spectrometry(HPCE-ESI-MS n) was employed to separate the platinum complex and the possible products of dissociation, to identify and quantify as well. It shows that this novel compound remains prototype at the range of pH 5. 0-9. 0. At pH value lower than 5. 0, SM54111 disassociates by clearage producing monodentate platinum complex which was detected and identified with ESI-MS n. A type of novel cleavage was obtained by the compound tested, which indicated that the ionization rate depended on the ionization codition. It was proved that SM54111's stability at physiological pH in solution was demonstrated and HPCE-ESI-MS/MS was a convenient and useful tool for the analysis of platinum complex. The results offered the method and reference for the study on the pharmacokinetics and pharmacology of SM54111.",
        "keywords": [
            "Anticancer compound",
            "Electrospray ionization mass spectrometry",
            "High performance capillary electrophoresis",
            "Platinum complex",
            "Stability"
        ],
        "authors": [
            {
                "name": "Qiang Su",
                "org": "Shenyang Pharmaceutical University(Shenyang Pharmaceutical University),Shenyang,China"
            },
            {
                "name": "Liu Qing-Fei",
                "org": "Tsinghua University(Tsinghua University,Tsinghua Univ,Tsinghua Univ.),Beijing,China"
            },
            {
                "name": "Wu Juan-Fang",
                "org": "Tsinghua University(Tsinghua University,Tsinghua Univ,Tsinghua Univ.),Beijing,China"
            },
            {
                "name": "Wang Yi-Ming",
                "org": "Tsinghua University(Tsinghua University,Tsinghua Univ,Tsinghua Univ.),Beijing,China"
            },
            {
                "name": "Bi Kai-Shun",
                "org": "Shenyang Pharmaceutical University(Shenyang Pharmaceutical University),Shenyang,China"
            },
            {
                "name": "Liu Wei-Ping",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Luo Guo-An",
                "org": "Tsinghua University(Tsinghua University,Tsinghua Univ,Tsinghua Univ.),Beijing,China"
            }
        ],
        "venue": "Fenxi Huaxue/ Chinese Journal of Analytical Chemistry",
        "year": 2007
    },
    "yMAdaMOT": {
        "id": "yMAdaMOT",
        "title": "Synthesis and Structure of Rhodium Octanoate",
        "abstract": "A new method was established to synthesize rhodium octanoate,an important catalyst for C-H insertion process.The direct reaction between RhCl3\u00b73H2O and C7H15COOH in water at pH\u22485 produced rhodium octanoate with a yield of more than 95% based on RhCl3\u00b73H2O.The purity of the product was determined by HPLC to be greater than 99.0%.The structural studies by MS,IR,NMR and single X-ray diffraction reveal that rhodium octanoate is a dimeric coordination compound in which two rhodium atoms are bridged by four octanoate COO-groups,forming 'lantern-like' structure.",
        "keywords": [
            "structure",
            "rhodium octanoate",
            "synthesis",
            "organic chemistry"
        ],
        "authors": [
            {
                "name": "LIU Guihua",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "YE Qingsong",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "PAN Zaifu",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "HOU Wenming",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "SHEN Shanwen",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "YU Yao",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "CHEN Xizhu",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "JIANG Jing",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "LIU Weiping",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            }
        ],
        "venue": "Precious Metals",
        "year": 2012
    },
    "zLuIwn1K": {
        "id": "zLuIwn1K",
        "title": "cis-[Pt(II) (1R,2R-DACH)(3-acetoxy-1,1-cyclobutanedicarboxylato)], a water-soluble, oxalate-free and stable analogue of oxaliplatin: synthesis, characterization, and biological evaluations.",
        "abstract": "",
        "keywords": [
            "antitumor agents",
            "biological activity",
            "oxaliplatin",
            "platinum",
            "synthesis"
        ],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "State Key Lab for Platinum Group Metals, Kunming Institute of Precious Metals, 650106 Yunnan, China."
            },
            {
                "name": "Qingsong Ye",
                "org": ""
            },
            {
                "name": "Jing Jiang",
                "org": ""
            },
            {
                "name": "Liguang Lou",
                "org": ""
            },
            {
                "name": "Yongping Xu",
                "org": ""
            },
            {
                "name": "Chengying Xie",
                "org": ""
            },
            {
                "name": "Mingjin Xie",
                "org": ""
            }
        ],
        "venue": "ChemMedChem",
        "year": 2013
    },
    "1u9XV5mt": {
        "id": "1u9XV5mt",
        "title": "Non-coordination planer <Emphasis Type=\"Italic\">cis</Emphasis>-and <Emphasis Type=\"Italic\">trans</Emphasis>-configuration of <Emphasis Type=\"Italic\">cis</Emphasis>-[Pt(II)(mixed-NH<Subscript>3</Subscript>/RNH<Subscript>2</Subscript>)(3-OH-cyclobutane-1,1-dicarboxylate)]: separation, characterization, and anticancer activity",
        "abstract": "Two isomers of cis-[Pt(II)(mixed-NH3/RNH2)(3-OH-cyclobutane-1,1-dicarboxylate)] (R\u2009=\u2009cycopentyl, cyclohexyl) were separated, structurally characterized and tested for their anticancer activity. X-ray structural analysis revealed that this isomerism originates from two opposite spatial orientations of the hydroxyl group on the cyclobutane ring in relation to the coordinated NH3, resulting in cis- and trans-configurations. The two isomers have approximately equal anticancer activity, probably due to a relatively long distance between the hydroxyl group and the Pt(II) coordination plane. Therefore, the separation of such isomers is not recommended during drug development.",
        "keywords": [
            "Platinum(II) complexes",
            " Anticancer activity",
            " 3-OH-cyclobutane-1",
            "1-dicarboxylate",
            " Mixed-NH3/RNH2",
            " Non-coordination planer cis-/trans-isomerism"
        ],
        "authors": [
            {
                "name": "Jing\u00a0Jiang",
                "org": "State Key Laboratory for Platinum Group Metals,Kunming Institute of Precious Metals,Kunming,People\u2019s Republic of China"
            },
            {
                "name": "Jie\u00a0Qiu",
                "org": "Lincan Maternal and Child Health Care Hospital,Kaiyuan,People\u2019s Republic of China"
            },
            {
                "name": "Liguang\u00a0Lou",
                "org": "Shanghai Institute of Materia Medica,Chinese Academy of Science,Shanghai,People\u2019s Republic of China"
            },
            {
                "name": "Anli\u00a0Gao",
                "org": "State Key Laboratory for Platinum Group Metals,Kunming Institute of Precious Metals,Kunming,People\u2019s Republic of China"
            },
            {
                "name": "Shuqian\u00a0Hou",
                "org": "State Key Laboratory for Platinum Group Metals,Kunming Institute of Precious Metals,Kunming,People\u2019s Republic of China"
            },
            {
                "name": "Weiping\u00a0Liu",
                "org": "State Key Laboratory for Platinum Group Metals,Kunming Institute of Precious Metals,Kunming,People\u2019s Republic of China"
            }
        ],
        "venue": "Research on Chemical Intermediates",
        "year": 2018
    },
    "NzcyiGkB": {
        "id": "NzcyiGkB",
        "title": "Two mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group.",
        "abstract": "Two mixed-NH3/amine platinum (II) complexes of 3-dichoroacetoxylcyclobutane-1, 1-dicarboxylate have been prepared in the present study and characterized by elemental analysis and IR, HPLC-MS and (1)H, (13)C-NMR. The complexes exist in equilibrium between two position isomeric forms and undergo hydrolysis reaction in aqueous solution, releasing the platinum pharmacophores and dichloroacetate which is a small-molecular cell apoptosis inducer. Both complexes were evaluated for in vitro cytotoxic profile in A549, SGC-7901 and SK-OV-3 cancer cells as well as in BEAS-2B normal cells. They exhibit markedly cytotoxicity toward cancer cells by selectively inducing the apoptosis of cancer cells, whereas leaving normal cells less affected. They have also the ability to overcome the resistance of SK-OV-3 cancer cells to cisplatin. Our findings offer an alternative novel way to develop platinum drugs which can both overcome the drug resistance and selectively target tumor cells.",
        "keywords": [
            "apoptosis"
        ],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "State Key Laboratory for Platinum Group Metals, Kunming Institute of Precious Metals, 650106 Yunnan, China."
            },
            {
                "name": "Jia Su",
                "org": ""
            },
            {
                "name": "Jing Jiang",
                "org": ""
            },
            {
                "name": "Xingyao Li",
                "org": ""
            },
            {
                "name": "Qingsong Ye",
                "org": ""
            },
            {
                "name": "Hongyu Zhou",
                "org": ""
            },
            {
                "name": "Jialin Chen",
                "org": ""
            },
            {
                "name": "Yan Li",
                "org": ""
            }
        ],
        "venue": "Scientific reports",
        "year": 2013
    },
    "UyE4TPhZ": {
        "id": "UyE4TPhZ",
        "title": "Analysis of a novel platinum anticancer compound HJ5 by high performance liquid chromatography]",
        "abstract": "Cis-dichloroamine (4-amino-2, 2, 6, 6-tetramethylpiperidine-1-oxyl) platinum (II) (abbreviated to HJ5) is a novel platinum anticancer compound which has prospects for research and application. In order to establish a conventional analytical method, an HPLC has been studied. Under the conditions of acetonitrile-water (10:90, volume ratio) as mobile phase, detection wavelength of 210 nm, a Phenomenex column C18(150 mm x 3.9 mm i.d., 10 microns). The linear equation, recovery and accuracy of the method were determined with external standard method. The HPLC has satisfactory resolution between the peaks of HJ5 and impurities. The peak areas of HJ5 were linear to its amounts detected and the detection limit was 0.07 microgram. The hydration of HJ5 can be inhibited effectively by NaCl solution. In a 9 g/L NaCl solution, the stability can be kept for more than 2 hours which is enough for analysis.",
        "keywords": [],
        "authors": [
            {
                "name": "Yang Liu",
                "org": "Research Center of Precious Metal-Based Drugs, Kunming Institute of Precious Metals, Kunming 650221, China."
            },
            {
                "name": "Jian He",
                "org": ""
            },
            {
                "name": "Zhu-dong Liu",
                "org": ""
            },
            {
                "name": "Xi-zhu Chen",
                "org": ""
            },
            {
                "name": "Wei-ping Liu",
                "org": ""
            }
        ],
        "venue": "Se pu = Chinese journal of chromatography / Zhongguo hua xue hui",
        "year": 2002
    },
    "2RDdFCSI": {
        "id": "2RDdFCSI",
        "title": "Synthesis and Hypoglycemic Effects of Derivatives of Bia(a-furancarboxylato) Oxovanadium(IV)",
        "abstract": "Objective To design and synthesize derivatives of bis(a-furancarboxylato)oxovanadium(IV) (VO-FA), and to compare their hypoglycemic effects with VO-FA in alloxan-diabetic mice. Methods The chemical structure of the derivatives was determined by elemental analysis, IR, UV, MS and H NMR spectra. The Effects of the derivatives on the blood glucose concentrations were investigated in alloxan-induced diabetic mice. Results During the experiment, bis(a-tetrahydrofurancarboxylato)oxovanadium(IV) (VO-HFA) reduced the blood glucose in alloxan- diabetic mice, but was less active than the parent compound VO-FA. Bis(5-bromo-a-furancarboxylato)oxovanadium(IV) (VO-FABr) had no hypoglycemic effect. Both derivatives were more toxic than VO-FA. Conclusion Hydrogen addition of C=C in the ring or introduction of bromine will lower hypoglycemic activity and increase toxicity of the parent compound.",
        "keywords": [
            "Bis(a-furancarboxylato)oxovanadium(IV)",
            "Blood glucose",
            "Derivative",
            "Synthesis",
            "Diabetic mice"
        ],
        "authors": [
            {
                "name": "NIU Yan-fen",
                "org": " %%#1%%# Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming "
            },
            {
                "name": "XIE Ming-jin",
                "org": "Dept. of Chemistry, Yunnan University, Kunming, "
            },
            {
                "name": "LI Yan-rong",
                "org": " %%#1%%# Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming "
            },
            {
                "name": "LIU Wei-ping",
                "org": "Kunming Institute of Precious Metals, Kunming "
            },
            {
                "name": "YAN Shi-ping",
                "org": "Dept. of Chemistry, Nankai University, Tianjin ,China)"
            },
            {
                "name": "LI Ling",
                "org": " %%#1%%# Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming "
            }
        ],
        "venue": "Journal of Kunming Medical College",
        "year": 2006
    },
    "nOFUcgVx": {
        "id": "nOFUcgVx",
        "title": "Synthesis and Characterization of Cis-diaminedithiocyanatoplatinum(\u2161) and Study on Mechanism of a Precipitation from the Aqueous Solution",
        "abstract": "Cis-diaminedithiocyanatoplatinum(\u2161)(cis-[Pt(SCN)2(NH3)2])was prepared and characterized through content analysis of Pt,MS,IR.The results show that the complex has cis configuration and the bond type of Pt and SCN-is Pt-S.When the aqueous solution of the complex was stored for one week,an orange-yellow precipitation appeared,different from the complex with light yellow color.Further comparative studies of these two complexes suggested that the precipitation is cis-[Pt(NCS)2(NH3)2],the linkage isomerism of cis-[Pt(SCN)2(NH3)2].The mechanism of the isomerism reaction is also discussed.",
        "keywords": [
            "platinum complex",
            "cis-diaminedithiocyanato/isothiocyanatoplatinum(\u2161)",
            "thiocyanato/isothiocyanato",
            "aqueous solution"
        ],
        "authors": [
            {
                "name": "LIU Yang",
                "org": "Metal-based Drugs Lab,Institute of Precious Metals,Kunming "
            },
            {
                "name": "YU Yao",
                "org": "Metal-based Drugs Lab,Institute of Precious Metals,Kunming "
            },
            {
                "name": "GAO Wen-Gui",
                "org": "Metal-based Drugs Lab,Institute of Precious Metals,Kunming "
            },
            {
                "name": "CHEN Xi-Zhu",
                "org": "Metal-based Drugs Lab,Institute of Precious Metals,Kunming "
            },
            {
                "name": "XIE Xiao-Tian",
                "org": "Chemistry and Chemical Engineering College,Yunnan Normal University,Kunming "
            },
            {
                "name": "LIU Wei-Ping",
                "org": ""
            }
        ],
        "venue": "Chinese Journal of Inorganic Chemistry",
        "year": 2006
    },
    "hQY21hSX": {
        "id": "hQY21hSX",
        "title": "cis -(Malonato-\u03ba 2 O , O \u2032)bis(2-methylpyridine-\u03ba N )platinum(II)",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "mingjin xie",
                "org": ""
            },
            {
                "name": "yu yao",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "shuqian hou",
                "org": ""
            },
            {
                "name": "xizhu chen",
                "org": ""
            }
        ],
        "venue": "Acta Crystallographica Section E-structure Reports Online",
        "year": 2007
    },
    "HkpV3nfo": {
        "id": "HkpV3nfo",
        "title": "Preparation and Characterization of Pt/C Catalysts by Modified Polyol Method",
        "abstract": "Supported Pt/C catalysts used in proton exchange membrane fuel cells(PEMFC) were prepared by a traditional polyol process and a modified polyol method,and then compared.In the so-called modified polyol process,highly monodispersed nanoparticles and homogeneous distribution on the carbon support can be obtained by reduction of Pt metallic precursors previously supported on carbon powders.TEM,XRD and CV were carried out to characterize the morphology,composition and the electrochemical properties of the Pt/C catalysts.It was found that the Pt/C catalysts prepared using the traditional polyol process as the reduction before support(RS) were liable to agglomeration.But Pt/C catalysts prepared by the modified polyol method with support before reduction(SR) had a better distribution and uniform particle dispersity with the average diameter in the range of 1.2~3.2nm.Cyclic voltammograms show that the as-prepared catalyst latter exhibited better electrochemical performance with the mass activity(MA) of 23.42 A/g.",
        "keywords": [
            "modified polyol method",
            "Pt/C catalysts",
            "physical chemistry",
            "electrochemical performance",
            "proton exchange membrane fuel cell"
        ],
        "authors": [
            {
                "name": "ZHU Fangfang",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "ZHANG Kunhua",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "LIU Weiping",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "YU Yao",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "ZHANG Junmin",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "GUAN Weiming",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            }
        ],
        "venue": "Precious Metals",
        "year": 2012
    },
    "lN6xbovg": {
        "id": "lN6xbovg",
        "title": "Determination of copper aspirinate by high performance liquid chromatography",
        "abstract": "A method for determining copper aspirinate [Cu(ASA)2]2 has been studied by using reversed-phase high performance liquid chromatography with YWQ C18 column, MeOH:H2O (containing 0.08% H3PO4):CH3COCH3(11.4 = 8.6:1.1) as mobile phase and UV-235 mn as detector. The results showed that [Cu(ASA)2]2 and copper salicylate [Cu(SA)2]2 could separated satisfactorily. The detection limits of [Cu(ASA)2]2 and [Cu(SA)2]2 were 0.87 mg/L, 2.46 mg/L respectively and the corresponding recoveries were 99.0% \u223c 100.5%.",
        "keywords": [
            "Copper aspirinate",
            "High performance liquid chromatography"
        ],
        "authors": [
            {
                "name": "ZhuDong Liu",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Yikun Yang",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Shaoping Pu",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Xizhu Chen",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Jian He",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Huizhou Xiong",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            }
        ],
        "venue": "Fenxi Huaxue",
        "year": 1999
    },
    "ltNr55Xc": {
        "id": "ltNr55Xc",
        "title": "In vivo insulin-mimetic activity of [N,N'-1,3-propyl-bis(salicyladimine)]oxovanadium(IV).",
        "abstract": "[N,N'-1,3-Propyl-bis(salicyladimine)]oxovanadium(IV) - an oxovanadium complex has been tested for bioactivity as an insulin-enhancing agent. Its structure reveals that the vanadium(IV) ion is hexacoordinated and situated in a distorted octahedral environment. The complex was administered intragastrically to both normal and streptozotocin (STZ)-diabetic rats for two weeks. The results showed that the complex, at a dose of 10.0 and 20.0mgV.kg(-1), could lower the blood glucose level in STZ-diabetic rats and improve the response to an oral glucose challenge. This complex did not alter these parameters in normal rats. It was suggested that the complex exerted an antidiabetic effect in STZ-diabetic rats.",
        "keywords": [
            "n",
            "oxovanadium",
            "insulinomimetic activity",
            "3-propyl-bis(salicyladimine)",
            "n\u2032-1"
        ],
        "authors": [
            {
                "name": "Mingjin Xie",
                "org": ""
            },
            {
                "name": "Guangjun Xu",
                "org": ""
            },
            {
                "name": "Ling Li",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Yanfen Niu",
                "org": ""
            },
            {
                "name": "Shiping Yan",
                "org": ""
            }
        ],
        "venue": "European journal of medicinal chemistry",
        "year": 2007
    },
    "9zRpaLc9": {
        "id": "9zRpaLc9",
        "title": "(Cyclobutane-1,1-dicarboxylato)(2-morpholino-ethylamine)platinum(II) trihydrate",
        "abstract": "The reaction of 2-morpholinoethylamine and cyclobutane-1,1-dicarboxylic acid with potassium tetrachloroplatinate(II) produced the monomeric title complex, [Pt(C6H6O4)(C6H 14N2O)]\u00b73H2O. The PtII ion is tetracoordinated and situated in a square-planar environment. \u00a9 2007 International Union of Crystallography. All rights reserved.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Mingjin Xie",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            },
            {
                "name": "Xizhu Chen",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Yao Yu",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Qing Shong Ye",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            }
        ],
        "venue": "Acta Crystallographica Section E: Structure Reports Online",
        "year": 2007
    },
    "jE4dMr2t": {
        "id": "jE4dMr2t",
        "title": "~1H NMR Characteristics of New Carboplatin Derivatives",
        "abstract": "Carboplatin is one of the most important anticancer drugs among the second generation of platinum metal-based drugs,and widely used in clinics. To find new carbopaltin drugs with stronger anticancer efficacy,six new carbopaltin derivatives were synthesized. In the paper,the ~1H NMR chemical shift assignment of 4 new carbopaltin derivatives was obtained,and the ~1H NMR characteristics of these compounds was also discussed.",
        "keywords": [
            "~1H NMR",
            "carboplatin",
            "anticancer drugs",
            "assignments"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "GAO Chuan-zhu",
                "org": "Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "CHEN Xi-zhu",
                "org": "Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "QIU Ming-hua",
                "org": "State Key Laboratory Phytochemistry and Plant Resource in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming ,China"
            }
        ],
        "venue": "Chinese Journal of Magnetic Resonance",
        "year": 2006
    },
    "QIj3Ej4g": {
        "id": "QIj3Ej4g",
        "title": "Application of Precious Metal Catalysts in Drug Synthesis",
        "abstract": "Supported precious metal catalysts with high activity and high selectivity have been widely used in the drug synthesis as well as the fine chemical industry.The application of the catalysts in drug synthetic reactions including hydroformylation,hydrosilylation,isomerization,hydrogenolysis,transfer hydrogenation and coupling were introduced.The latest research and development were also summarized.",
        "keywords": [
            "drug synthesis",
            "Supported precious metal catalysts",
            "application",
            "physical chemistry"
        ],
        "authors": [
            {
                "name": "MENG Qingquan",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China;School of Chemical Engineering, Kunming University of Science and Technology,Kunming ,China"
            },
            {
                "name": "YE Qingsong",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "LIU Weiping",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "WANG Yaming",
                "org": "School of Chemical Engineering, Kunming University of Science and Technology,Kunming ,China"
            }
        ],
        "venue": "Precious Metals",
        "year": 2012
    },
    "BbvyBh2J": {
        "id": "BbvyBh2J",
        "title": "Pharmacokinetic investigation on a novel antitumour platinum compound in rabbit plasma by inductively coupled plasma mass spectrometry after intravenous administration.",
        "abstract": "The purpose of this study was to investigate a novel platinum anticancer compound named as SM54111 [cis-3, 5-diisopropylsalylic cyclohexanodiaminoplatinum (II)], which is under development as a new drug candidate, on its pharmacokinetics in plasma after intravenous administration to rabbits at concentration of 2.5, 5.0, and 9.0 mg/kg. The concentration of SM54111 in plasma expressed as Pt was determined utilizing ICP-MS method, and the method was thoroughly validated. The data were analyzed with 3P97 pharmacokinetic software to find the parameters. The results showed that the linear range lay at the 1 approximately 1000 ng/mL level, and the LOD and LOQ were 0.4 ng/mL and 1 ng/mL, respectively. It proved that this new drug candidate underwent disposition in rabbit plasma by a two-compartment open model at the three doses above, and the main pharmacokinetic parameters were obtained as the initial concentrations of three doses (C(0)) were 8.68 +/- 0.80, 20.04 +/- 1.92, and 28.88 +/- 2.32 mg/L, respectively; the areas under concentration-time profile from time 0 to 72 h (AUC(0 approximately t)) were 90.0 +/- 13.0, 251.3 +/- 45.3, and 396.9 +/- 61.1 mg*h/L, respectively; the terminal elimination half-life times (t(1/2beta)) 29.1 +/- 4.8, 35.2 +/- 7.5, and 29.4 +/- 2.8 h, respectively; and the total clearances (CL(tot)) were 0.026 +/- 0.004, 0.019 +/- 0.002, and 0.022 +/- 0.004 L/h, respectively. First order rate pharmacokinetics were observed for SM54111 with the doses used, and it showed a long retention and slow elimination in vivo, There showed no prolongation of the t(1/2beta) with larger dose, and the CLs of the three doses were proximate. It is reasonable to surmise that SM54111 follows first order rate pharmacokinetics, and no saturation was detected at concentrations from 2.5 to 9.0 mg/kg. This result suggested that SM54111 experienced an amiable procedure in vivo and was worthy of the further development.",
        "keywords": [
            "anticancer",
            "pharmacokinetics",
            "icp-ms",
            "sm54111",
            "platinumcomplex",
            "icp ms",
            "inductively coupled plasma mass spectrometry"
        ],
        "authors": [
            {
                "name": "Qiang Su",
                "org": ""
            },
            {
                "name": "Qingfei Liu",
                "org": ""
            },
            {
                "name": "Guoan Luo",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Yao Yu",
                "org": ""
            },
            {
                "name": "Yiming Wang",
                "org": ""
            },
            {
                "name": "Kaishun Bi",
                "org": ""
            }
        ],
        "venue": "Drug development and industrial pharmacy",
        "year": 2008
    },
    "xkkjkFZw": {
        "id": "xkkjkFZw",
        "title": "Research and Application of Platinum Metal Homogeneous Catalysts",
        "abstract": "Platinum metal homogeneous catalysts are a kind of metal coordination compounds with unique chemical structures.They are able to catalyze effectively many reactions including hydrogenation,carbonylation,hydroformylation,oxidation of alkenes and C-C bond formation and so on,and have been used in small-scale laboratory preparations and increasingly in industrially areas especially in the pharmaceutical industry.The catalystic mechanism involves oxidative addition,intramolecular ligand rearrangement,ligand migration and insertion and finally reductive elimination.The history and application of platinum metal homogeneous catalysts are introduced,and related mechanism and new progress are also reviewed.",
        "keywords": [
            "platinum group metals",
            "application",
            "mechanism",
            "homogeneous catalysis",
            "catalysts"
        ],
        "authors": [
            {
                "name": "PAN Zaifu",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "LIU Weiping",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "CHEN Jialin",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            }
        ],
        "venue": "Precious Metals",
        "year": 2009
    },
    "PfG4H93D": {
        "id": "PfG4H93D",
        "title": "Preparation, Characterization and in Vitro Anticancer Activity of Platinum(II) Complexes with N-Cyclohexyl-1,3-propanediamine as the Carrier",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yao yu",
                "org": ""
            },
            {
                "name": "qingsong ye",
                "org": ""
            },
            {
                "name": "xizhu chen",
                "org": ""
            },
            {
                "name": "chen qing",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "shuqian hou",
                "org": ""
            }
        ],
        "venue": "Chemical & Pharmaceutical Bulletin",
        "year": 2008
    },
    "iLZSMpaZ": {
        "id": "iLZSMpaZ",
        "title": "Synthesis, characterization and cytotoxic activity of a new oxaliplatin analog.",
        "abstract": "null",
        "keywords": [
            "oxaliplatin analog",
            "cytotoxic activity",
            "characterization"
        ],
        "authors": [
            {
                "name": "Yao Yu",
                "org": "Platinum-based Drug Laboratory,Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "Wei-Ping Liu",
                "org": "Platinum-based Drug Laboratory,Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "Ning Cui",
                "org": "Platinum-based Drug Laboratory,Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "Li-Guang Lou",
                "org": "Shanghai Institute of Materia Medica,China Academy of Science,Shanghai ,China"
            },
            {
                "name": "Hua-Jie Zhu",
                "org": "Kunming Institute of Botany,China Academy of Science,Kunming ,China"
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2006
    },
    "iUVTPBDc": {
        "id": "iUVTPBDc",
        "title": "Synthesis and Anticancer Activity of 3-benzyloxy-1,1-dicarboxycyclobutane Diammine Platinum(\u2161)",
        "abstract": "Platinum-based drugs are one of the most important anticancer drugs in clinical use.In this paper,a new platinum complex,3-benzyloxy-1,1-dicarboxycyclobutane diammine platinum(\u2161) was synthesized.Its structure is confirmed by modern analytical techniques.IC50 of the compound is 4.8mg/L for A549 tumor cells and 18.0mg/L for KB tumor cells,respectively.",
        "keywords": [
            "pharmaceutical chemistry",
            "platinum-based compound",
            "anticancer activity",
            "characterization",
            "synthesize"
        ],
        "authors": [
            {
                "name": "GAO Chuanzhu",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China;Kunming GUIYAN Pharmaceutical Co.Ltd.,Kunming,Yunnan ,China"
            },
            {
                "name": "LIU Weiping",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "PU Shaoping",
                "org": "Kunming GUIYAN Pharmaceutical Co.Ltd.,Kunming,Yunnan ,China;Kunming University of Science and Technology,Kunming,Yunnan ,China"
            },
            {
                "name": "GAO Wengui",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            }
        ],
        "venue": "Precious Metals",
        "year": 2007
    },
    "gGvnMXbn": {
        "id": "gGvnMXbn",
        "title": "Synthesis and anticancer activity of a new water-soluble derivative of heptaplatin, -{Pt(II)[(4,5)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](3-acetoxyl-cyclobutane-1,1-dicarboxylato)}",
        "abstract": "\nA new water-soluble derivative of heptaplatin, -{Pt(II)[(4,5)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](3-acetoxyl-cyclobutane-1,1-dicarboxylato)} has been synthesized, characterized by elemental analysis, MS, IR, and H, C NMR, and evaluated for in vitro anticancer activity in four human cancer cell lines. The stability of the derivative in water was also investigated by monitoring the changes of H NMR in DO. The results reveal that the new derivative has good solubility and stability in water and also shows high anticancer activity against gastric cancer cells, ovarian cancer cells, and colon cancer cells. Therefore, it is worthy of further evaluation for in vivo antitumor activity and toxicity.",
        "keywords": [
            "Platinum complexes",
            "Heptaplatin",
            "Synthesis",
            "Anticancer"
        ],
        "authors": [
            {
                "name": "Jing\u00a0Jiang",
                "org": "State Key Lab of Advanced Technologies for PGM,Kunming Institute of Precious Metals,Kunming,China"
            },
            {
                "name": "Jing\u00a0Lei",
                "org": "School of Chemistry,Hunan Normal University,Changsha,China"
            },
            {
                "name": "Xi-Zhu\u00a0Chen",
                "org": "State Key Lab of Advanced Technologies for PGM,Kunming Institute of Precious Metals,Kunming,China"
            },
            {
                "name": "Li-Guang\u00a0Lou",
                "org": "Shanghai Institute of Materia Medica,Chinese Academy of Science,Shanghai,China"
            },
            {
                "name": "Qing-Song\u00a0Ye",
                "org": "State Key Lab of Advanced Technologies for PGM,Kunming Institute of Precious Metals,Kunming,China"
            },
            {
                "name": "Qiao-Wen\u00a0Chang",
                "org": "State Key Lab of Advanced Technologies for PGM,Kunming Institute of Precious Metals,Kunming,China"
            },
            {
                "name": "Yong-Ping\u00a0Xu",
                "org": "Shanghai Institute of Materia Medica,Chinese Academy of Science,Shanghai,China"
            },
            {
                "name": "Wei-Ping\u00a0Liu",
                "org": "State Key Lab of Advanced Technologies for PGM,Kunming Institute of Precious Metals,Kunming,China"
            }
        ],
        "venue": "Research on Chemical Intermediates",
        "year": 2015
    },
    "W9YrOBM3": {
        "id": "W9YrOBM3",
        "title": "Insulino-mimetic effects of bis (\u03b1-furancarboxylato) oxovanadium (IV) in vitro",
        "abstract": "To study insulino-mimetic effects of bis (\u03b1-furancarboxylato) oxovanadium (IV) (BFOV), a orally active antidiabetic vanadyl complex, on glucose uptake and lipogenesis in isolated rat adipocytes were determined by using 2-deoxy-D-[3H]-glucose and D-[3H]-glucose, respectively. Lipolysis was assayed by free fatty acids (FFA) released from isolated rat adipocytes treated with epinephrine. The results showed that BFOV, similar to insulin, concentration-dependently significantly enhanced the uptake of 2-deoxy-D-[3H]-glucose and the transformation from D-[ 3H]-glucose to lipid in isolated rat adipocytes, with the EC 50 values of (0.31 \u00b1 0.08) mmol\u00b7L-1 and (0.49 \u00b1 0.12) mmol\u00b7L-1, respectively. Moreover, BFOV markedly inhibited FFA release from isolated rat adipocytes treated with epinephrine, and the IC50 value was (0.30 \u00b1 0.20) mmol\u00b7L-1. BFOV had insulino-mimetic effects such as enhancing glucose uptake and lipogenesis, as well as inhibiting lipolysis.",
        "keywords": [
            "Adipocyte",
            "Bis (\u03b1-furancarboxylato) oxovanadium (IV)",
            "Glucose uptake",
            "Lipogenesis",
            "Lipolysis"
        ],
        "authors": [
            {
                "name": "LI Yan-rong",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "GAO Li-hui",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "MA Yan-lin",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "NIU Yan-fen",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Ling Li",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            }
        ],
        "venue": "Acta Pharmaceutica Sinica",
        "year": 2008
    },
    "aMvFycwK": {
        "id": "aMvFycwK",
        "title": "Quick determination of copper salicylate in copper aspirinate",
        "abstract": "OBJECTIVE: To establish an analytical method of copper salicylate which can be applied to the quality control of copper aspirinate during the synthesis process. METHODS: By combination of complexing dissolution, solvent extraction and photometric measurement, the amount of salicylic acid was first obtained and then converted to the content of copper salicylate. RESULTS: The analysis limitation of copper salicylate was between 0.1% - 5% and the recovery varied from 97% - 104% with RSD less than 3.3%. CONCLUSION: The established method here was simple, rapid and accurate, suitable for mornitoring the synthesis process of copper aspirinate.",
        "keywords": [
            "Analysis",
            "Copper aspirinate",
            "Copper salicylate"
        ],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "ZhuDong Liu",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Xizhu Chen",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Shaoping Pu",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Yang Liu",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Yikun Yang",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            }
        ],
        "venue": "Chinese Pharmaceutical Journal",
        "year": 2000
    },
    "ZCcsIFoG": {
        "id": "ZCcsIFoG",
        "title": "Preparation and Characterization of Mesoporous Y_2O_3 and Nd_2O_3 Films",
        "abstract": "With poly(ethylene-co-butylene)block-poly(ethylene oxide) block copolymer(PHB-PEO) as the template,mesostructured Y_2O_3 and Nd_2O_3 thin films were successfully synthesized through the well-documented evaporation-induced self-assembly approach.The obtained samples calcined at different temperatures were characterized in detail by using small-and wide-angle X-ray diffraction and transmission electron microscopy(TEM).The results show that our presented Y_2O_3 and Nd_2O_3 thin films possessed an Im3m body-centered-(cubic(BCC)) array of distorted spherical pores with an average pore diameter of about 11.5 and 12.5 nm,(respectively).Furthermore,the partial crystalline pore walls can stabilize at 450 \u2103.The investigation also(indicated) that a rapid self-assembly process is necessary to generate the mesoporous Y_2O_3 and Nd_2O_3 thin films.It can be achieved by the utilization of PHB-PEO template and the fast dip-coating process of evaporation-(induced) self-assembly.",
        "keywords": [
            "Y_2O_3",
            "Block copolymer template",
            "Nd_2O_3",
            "Evaporation-induced self-(assembly)",
            "Mesoporous thin films"
        ],
        "authors": [
            {
                "name": "WANG Tong-Wen",
                "org": "College of Chemistry and Engineering,Yunnan Normal University,Kunming ,China"
            },
            {
                "name": "LIU Ling",
                "org": "College of Chemistry and Engineering,Yunnan Normal University,Kunming ,China"
            },
            {
                "name": "LIU Wei-Ping",
                "org": "Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "MA Zi-He",
                "org": "College of Chemistry and Engineering,Yunnan Normal University,Kunming ,China"
            },
            {
                "name": "Yang Zhi",
                "org": "College of Chemistry and Engineering,Yunnan Normal University,Kunming ,China"
            },
            {
                "name": "DUAN Ai-Hong",
                "org": "College of Chemistry and Engineering,Yunnan Normal University,Kunming ,China"
            },
            {
                "name": "RUAN Qiong",
                "org": "College of Chemistry and Engineering,Yunnan Normal University,Kunming ,China"
            }
        ],
        "venue": "Chemical Journal of Chinese Universities",
        "year": 2006
    },
    "OCsUE9yy": {
        "id": "OCsUE9yy",
        "title": "Fine Tuning of the Substituents on the N-Geminal Phosphorus/Silicon-Based Lewis Pairs for the Synthesis of Z -Type Silyliminophosphoranylalkenes",
        "abstract": "Reactions of the N-aryl(diphenylphosphanyl)aminosilane Ph2PN(Ar)SiCl3\u2013nMen (Ar = 2,4,6-Me3C6H2, n = 0 (1a), 1 (2a), 2 (3a), 3 (4a); Ar = 2,6-iPr2C6H3, n = 0 (1b), 1 (2b), 2 (3b), 3 (4b)) with methyl propiolate and dimethyl acetylenedicarboxylate (DMAD) give two types of products, the zwitterionic heterocycles [Ph2PN(2,4,6-Me3C6H2)SiCl3](HC\u2550CCO2Me) (5c) and [Ph2PN(Ar)SiCl3\u2013nMen](MeO2CC\u2550CCO2Me) (Ar = 2,4,6-Me3C6H2, n = 0 (5a), 1 (6a), 2 (7a); Ar = 2,6-iPr2C6H3, n = 0 (5b), 1 (6b), 2 (7b)) and (Z)-silyliminophosphoranylalkene ArN\u2550P(Ph2)C(CO2Me)\u2550C(CO2Me)SiMe3 (Ar = 2,4,6-Me3C6H2 (8a), 2,6-iPr2C6H3 (8b)). The reaction of Ph2PN(SiMe3)2 with DMAD gives only the acyclic alkene Me3SiN\u2550P(Ph2)(MeO2C)C\u2550C(CO2Me)SiMe3 (9), which is similar to 8a,b. In these reactions, compounds 1a\u20134a and 1b\u20134b behave as N-geminal P/Si-based Lewis pairs, which undergo a dipolar cycloaddition reaction with the alkyne. The theoretical calculations indicate that the reactions proceed through a concerted cycloaddition reaction mechanism. Th...",
        "keywords": [],
        "authors": [
            {
                "name": "bin li",
                "org": ""
            },
            {
                "name": "susmita de",
                "org": ""
            },
            {
                "name": "indu purushothaman",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "qingsong ye",
                "org": ""
            },
            {
                "name": "pattiyil parameswaran",
                "org": ""
            },
            {
                "name": "hongping zhu",
                "org": ""
            },
            {
                "name": "jiancheng li",
                "org": ""
            },
            {
                "name": "yan li",
                "org": ""
            }
        ],
        "venue": "Organometallics",
        "year": 2015
    },
    "vv4AcNH2": {
        "id": "vv4AcNH2",
        "title": "Synthesis and In Vitro cytotoxicity of Cis-[Pt(NH3)(NH2OH)Cl2]",
        "abstract": "",
        "keywords": [
            "nmr spectroscopy",
            "cell line",
            "water soluble"
        ],
        "authors": [
            {
                "name": "qingsong ye",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "xizhu chen",
                "org": ""
            },
            {
                "name": "yao yu",
                "org": ""
            },
            {
                "name": "qiaowen chang",
                "org": ""
            },
            {
                "name": "shuqian hou",
                "org": ""
            }
        ],
        "venue": "Archives of Pharmacal Research",
        "year": 2010
    },
    "kPzd623i": {
        "id": "kPzd623i",
        "title": "XPS and NMR Characteristics of Pt(acac)_2 and Pd(acac)_2",
        "abstract": "The coordination pattern between acac-and Pt(II),Pd(II) has been studied by X-photoelectronic spectrum and 1H-and 13C-nuclear magnetic resonance.The results showed that beside M\u2190L\u03c3coordination bondings,there still exists M\u2192L dxz(dyz) \u2192\u03c013 feedback \u03c0-bondings,which render acac-greater ability to form stable coordination compounds with Pt(II),Pd(II).",
        "keywords": [
            "Hacac",
            "Coordination chemistry",
            "XPS",
            "Platinum metal complex",
            "NMR"
        ],
        "authors": [
            {
                "name": "LIU Weiping",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "GAO Wengui",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "LIANG Guang",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "YAN Gexin",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "CHEN Xizhu",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "LIU Yang",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "YU Yao",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "WANG Yutian",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            }
        ],
        "venue": "Precious Metals",
        "year": 2005
    },
    "nNkpnXg0": {
        "id": "nNkpnXg0",
        "title": "Synthesis, characterization and cytotoxicity of diam(m)-ineplatinum(II) complexes containing beta-phenylisosuccinate ligand.",
        "abstract": "Four diam(m)ineplatinum(II) complexes containing beta-phenylisosuccinate as the leaving groups were prepared, characterized, and evaluated for their cytotoxicity against A549/ATCC human lung cancer cell line and SGC-7901 human gastric cancer cell line. One of the complexes, (trans-1R,2R-diaminocyclohexane)-beta-phenylisosuccinatoplatinum(II) 4, was much more active than cisplatin and carboplatin.",
        "keywords": [],
        "authors": [
            {
                "name": "Qing-Song Ye",
                "org": "Platinum-Based Drug Lab, Kunming Institute of Precious Metals, Kunming, Yunnan, China."
            },
            {
                "name": "Li-Guang Lou",
                "org": ""
            },
            {
                "name": "Zuo-Yan Liu",
                "org": ""
            },
            {
                "name": "Wei-Ping Liu",
                "org": ""
            },
            {
                "name": "Shu-Qian Hou",
                "org": ""
            },
            {
                "name": "Xi-Zhu Chen",
                "org": ""
            },
            {
                "name": "Yao Yu",
                "org": ""
            }
        ],
        "venue": "Archiv der Pharmazie",
        "year": 2007
    },
    "3ZRV94Xp": {
        "id": "3ZRV94Xp",
        "title": "Synthesis and Crystal Structure of Bis(2,2,6,6-tetramethyl-3,5-heptanedionato)palladium",
        "abstract": "A new precursor,bis(2,2,6,6-tetramethyl-3,5-heptanedionato)palladium was synthesized from PdCl2 and Hthd in methanol.The structure of bis(2,2,6,6-tetramethyl-3,5-heptanedionato) palladium was characterized by element alalysis,infrared spectroscopy,1HNMR spectroscopy and X-ray diffraction analysis.Thermal decomposition properties was studied by thermogravimetric analysis under nitrogen atmosphere.The results showed that bis(2,2,6,6-tetramethyl-3,5-heptanedionato) palladium was an ideal precursor for it was completely volatiled at 295\u2103.",
        "keywords": [
            "2",
            "6",
            "bis(2",
            "crystal structure",
            "5-heptanedionato)palladium",
            "6-tetramethyl-3",
            "synthesis",
            "organic chemistry"
        ],
        "authors": [
            {
                "name": "CHEN Gaofang",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "HU Changyi",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "CHEN Xizhu",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "YE Qingsong",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "LIU Weiping",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "CHANG Qiaowen",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            }
        ],
        "venue": "Precious Metals",
        "year": 2012
    },
    "2GXjiMJL": {
        "id": "2GXjiMJL",
        "title": "Research Situation of Precursors for Palladium Thin Films by MOCVD Process",
        "abstract": "Palladium thin film as a new precious metal material has a variety of important technological applications in many fields because of its excellent physical and chemical properties,such as protective coatings for high temperature,dielectric films in microelectronics and catalysis.It has attracted much attention in recent years due to its excellent properties and potential applications.In this article,the progress and situation on research of precursors for palladium thin films by MOCVD were introduced.The advantages and disadvantages of each precursors were discussed.The current focus and direction in the research field were summarized.",
        "keywords": [
            "precursors",
            "metal material",
            "palladium films",
            "MOCVD"
        ],
        "authors": [
            {
                "name": "CHEN Gaofang",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "CHANG Qiaowen",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "CHEN Xizhu",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "YE Qingsong",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "CHEN Liqiao",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "LIU Weiping",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals, Kunming Institute of Precious Metals,Kunming ,China"
            }
        ],
        "venue": "Precious Metals",
        "year": 2012
    },
    "WtC2Qfzf": {
        "id": "WtC2Qfzf",
        "title": "The antilipolytic action of bis(alpha-furancarboxylato)oxovanadium(IV) in adipocytes.",
        "abstract": "Previously, bis(alpha-furancarboxylato)oxovanadium(IV)(BFOV) exhibited potent hypoglycemic activity in diabetic animals. We evaluated the effects of BFOV on lipolysis in isolated rat adipocytes and lipid metabolism in fat-fed/streptozotocin (STZ)-induced diabetic rats, an animal model of type 2 diabetes.Antilipolytic action of BFOV was investigated by observing free fatty acids (FFA) release in isolated rat adipocytes treated with epinephrine and forskolin. Diabetic rats were induced by high-fat feeding plus STZ injection (25 mg/kg, i.p.). The rats were randomly divided into non-diabetic, diabetic, diabetic-BFOV (0.02, 0.06 and 0.2 mmol/kg) and diabetic-vanadyl sulfate group. All substances were given intragastrically to rats for 4 weeks. The concentrations of blood glucose, serum lipid and leptin, as well as body weight and food intake were determined.FFA release from adipocytes treated with epinephrine was markedly inhibited by BFOV and vanadyl sulfate, with the IC(50) values of 0.30+/-0.20 and 0.46+/-0.26 mmol/l, respectively, but not by insulin. Whereas, the inhibition of vanadyl compounds on FFA release triggered by forskolin in adipocytes were not observed. BFOV dose-dependently reduced serum triglycerides and FFA concentrations when compared with untreated diabetic rats (P<0.05), while it did not influence cholesterol concentrations, similar to vanadyl sulfate. Serum leptin concentration was also decreased both in the BFOV- and vanadyl sulfate-treated diabetic group (P<0.05). Moreover, BFOV markedly reduced blood glucose concentration and food intake (P<0.05), but it did not change the body weight of diabetic rats.BFOV has an antilipolytic action in adipocytes mediated by catecholamines. This action was distinct from that of insulin and also not related to inhibiting the activity of adenylate cyclase. In vivo, BFOV could improve dyslipidemia and leptin sensitivity in fat-fed/STZ-diabetic rats.",
        "keywords": [],
        "authors": [
            {
                "name": "Lihui Gao",
                "org": "Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming, PR China."
            },
            {
                "name": "Yanfen Niu",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Mingjin Xie",
                "org": ""
            },
            {
                "name": "Xu Liu",
                "org": ""
            },
            {
                "name": "Zhihe Chen",
                "org": ""
            },
            {
                "name": "Ling Li",
                "org": ""
            }
        ],
        "venue": "Clinica chimica acta; international journal of clinical chemistry",
        "year": 2008
    },
    "SivAT4wS": {
        "id": "SivAT4wS",
        "title": "Bis(alpha-furancarboxylato)oxovanadium(IV) prevents and improves dexamethasone-induced insulin resistance in 3T3-L1 adipocytes.",
        "abstract": "Previous studies showed that bis(alpha-furancarboxylato)oxovanadium(IV) (BFOV), an orally active anti-diabetic organic vanadium complex, could improve insulin resistance in animals with type 2 diabetes. The present study has been carried out to evaluate the effects of BFOV on insulin-resistant glucose metabolism using dexamethasone-treated 3T3-L1 adipocytes as an in-vitro model of insulin resistance. The results showed that BFOV, similar to vanadyl sulfate and rosiglitazone, caused a concentration-dependent increase in glucose consumption by insulin-resistant adipocytes. Moreover, BFOV enhanced the action of insulin and completely prevented the development of insulin resistance induced by dexamethasone, leading to glucose consumption equal to that by normal cells. In addition, dexamethasone reduced the mRNA expression of insulin receptor substrate 1 (IRS-1) and glucose transporter 4 (GLUT4) in 3T3-L1 adipocytes, while BFOV normalized the expression of IRS-1 and GLUT4. These findings suggest that BFOV prevents and improves dexamethasone-induced insulin resistance in 3T3-L1 adipocytes by enhancing expression of IRS-1 and GLUT4 mRNA.",
        "keywords": [],
        "authors": [
            {
                "name": "Yi-Qing Zuo",
                "org": "Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming, PR China."
            },
            {
                "name": "Wei-Ping Liu",
                "org": ""
            },
            {
                "name": "Yan-Fen Niu",
                "org": ""
            },
            {
                "name": "Chang-Fu Tian",
                "org": ""
            },
            {
                "name": "Ming-Jin Xie",
                "org": ""
            },
            {
                "name": "Xi-Zhu Chen",
                "org": ""
            },
            {
                "name": "Ling Li",
                "org": ""
            }
        ],
        "venue": "The Journal of pharmacy and pharmacology",
        "year": 2008
    },
    "MahcQe2g": {
        "id": "MahcQe2g",
        "title": "Potential application of copper aspirinate preventing and treating thromboembolic diseases",
        "abstract": "The efficacy of copper aspirinate against thrombotic diseases has been tested in animal models. The results show that copper aspirinate, following ig pretreatment for 7 days at 0.012mmol/kg markedly prolonged the bleeding time and inhibited the mortality induced by arachidonic acid (AA) in mice. On cereral ischemia model pretreatment with 0.018mmol/kg copper aspirinate ig significantly increased survival of animals and the density of intact hippocampal CA1 cells and decreased brain calcium concentration. Its anticerebral ischemia activity was superior to or equal to nimodipine. It is, therefore, suggested that copper aspirinate is very promising in becoming an antithrombotic drug in preventing and treating thrombotic diseases.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Huizhou Xiong",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Yikun Yang",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Ling Li",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "ZhiQiang Shen",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "ZhiHe Chen",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            }
        ],
        "venue": "Metal-Based Drugs",
        "year": 1998
    },
    "NEyc30ev": {
        "id": "NEyc30ev",
        "title": "Synthesis and anti-hyperglycemic effect of copper(II) bis(2-substituted 3-hydroxy-4-pyronate)",
        "abstract": "Copper(II) bis(2-substituted 3-hydroxy-4-pyronate), where the substituent is CH3/C2H5/CH2OH, was synthesized by the reaction between CuCl2 and sodium 2-substituted 3-hydroxy-4-pyronate in aqueous solution, followed by recrystallizaton in water. By using elemental analysis, IR, UV, MS and EPR spectra, their chemical structures were determined to be planar square complexes with 1:2 molar ratio of Cu to the pyronate in a molecule. The complexes were submitted to the test of preliminary toxicity and anti-hyperglycemic effect on STZ-diabetic mice. The results show that one of the complexes, copper(II) bis(2-ethyl-3-hydroxy-4- pyronate), increased the synthesis and release of the serum insulin, and lowered the blood glucose level in mice at the dose of 10 mg/kg, exhibiting good anti-hyperglycemic activity. The complex was also safe with LD50 of 855.9 mg/kg in healthy mice.",
        "keywords": [
            "3-hydroxy-4-pyrone",
            "Anti-hyperglycemic effect",
            "Copper(II)",
            "Synthesis"
        ],
        "authors": [
            {
                "name": "Xizhu Chen",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Yanfen Niu",
                "org": "Key Lab. Pharmacol. Nat. Prod. Y. P.(Key Lab. Pharmacol. Nat. Prod. Y. P.,Yunnan Pharmacological Laboratories of Natural Products,Pharmacol. Lab. Yunnan Prov. Nat. P.,Yunnan Key Lab. Pharmacol. N. P. R.,Yunnan Pharmacol. Labs. of Nat. P.),Kunming,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Ling Li",
                "org": "Key Lab. Pharmacol. Nat. Prod. Y. P.(Key Lab. Pharmacol. Nat. Prod. Y. P.,Yunnan Pharmacological Laboratories of Natural Products,Pharmacol. Lab. Yunnan Prov. Nat. P.,Yunnan Key Lab. Pharmacol. N. P. R.,Yunnan Pharmacol. Labs. of Nat. P.),Kunming,China"
            },
            {
                "name": "Yutian Wang",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Yanrong Li",
                "org": "Key Lab. Pharmacol. Nat. Prod. Y. P.(Key Lab. Pharmacol. Nat. Prod. Y. P.,Yunnan Pharmacological Laboratories of Natural Products,Pharmacol. Lab. Yunnan Prov. Nat. P.,Yunnan Key Lab. Pharmacol. N. P. R.,Yunnan Pharmacol. Labs. of Nat. P.),Kunming,China"
            },
            {
                "name": "Wengui Gao",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Yao Yu",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            }
        ],
        "venue": "Acta Chimica Sinica",
        "year": 2006
    },
    "q1f4n4sV": {
        "id": "q1f4n4sV",
        "title": "A Survey of Ruthenium Complexes as Nitric Oxide Modulators",
        "abstract": "The characteristics and mechanism of action of ruthenium(Ru) complexes as nitric oxide(NO) modulators were outlined.Several representative Ru complexes used as NO scavengers or releasers and their biological and pharmacological activities were introduced briefly.Ru-NO complexes show distinctive chemical properties,of which different types could selectively scavenge or release NO in vivo to modulate NO level,thus curing some diseases associated with NO.",
        "keywords": [
            "Nitric oxide modulator",
            "Nitric oxide releaser",
            "Nitric oxide scavenger",
            "Ruthenium complex"
        ],
        "authors": [
            {
                "name": "LIU Yang",
                "org": "Metal-based Drugs Lab,Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "YU Yao",
                "org": "Metal-based Drugs Lab,Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "GAO Wen-gui",
                "org": "Metal-based Drugs Lab,Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "CHEN Xi-zhu",
                "org": "Metal-based Drugs Lab,Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Metal-based Drugs Lab,Kunming Institute of Precious Metals,Kunming ,China"
            }
        ],
        "venue": "Progress in Pharmaceutical Sciences",
        "year": 2006
    },
    "vtJmGKPY": {
        "id": "vtJmGKPY",
        "title": "Structure and Properties of Pt/C Films Prepared by MOCVD",
        "abstract": "Pt/C films were prepared on silica glass and YSZ substrates by metal organic chemical vapor deposition (MOCVD) using platinum acetylacetonate as the precursor. The microstructure and some electrochemical properties were studied. Oxygen has important effects on the carbon contents of the Pt/C films. Small amount oxygen addition (3 ml/min) to the source gases decreases significantly the carbon contents of the films. The Pt/C film with higher carbon content has wider and lower XRD pattern of platinum, which has the characteristic of diffraction pattern of amorpha. The EMF values and output current of the oxygen concentration cell using Pt/C films as the electrodes are greater than those for other conventional platinum electrodes at 500\u2103.",
        "keywords": [
            "MOCVD",
            "platinum-carbon film",
            "microstructure",
            "composition",
            "property"
        ],
        "authors": [
            {
                "name": "Hu Changyi",
                "org": " Kunming Institute of Precious Metals, Kunming , China"
            },
            {
                "name": "Dai Jiaoyan",
                "org": " Central South University, Changsha , China"
            },
            {
                "name": "Fang Ying",
                "org": " Kunming Institute of Precious Metals, Kunming , China"
            },
            {
                "name": "Yan Gexin",
                "org": " Kunming Institute of Precious Metals, Kunming , China"
            },
            {
                "name": "Liu Weiping",
                "org": " Kunming Institute of Precious Metals, Kunming , China"
            },
            {
                "name": "Cheng Yong",
                "org": " Kunming Institute of Precious Metals, Kunming , China"
            }
        ],
        "venue": "Rare Metal Materials and Engineering",
        "year": 2006
    },
    "MCKklrlK": {
        "id": "MCKklrlK",
        "title": "Synthesis, anticancer activity and toxicity of a water-soluble 4S,5S-derivative of heptaplatin, cis-{Pt(II)[(4S,5S)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane]\u00b7(3-hydroxyl-cyclobutane-1,1-dicarboxylate)}.",
        "abstract": "A water-soluble 4S,5S-derivative of heptaplatin, cis-{Pt(II)[(4S,5S)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane]\u00b7(3-hydroxyl-cyclobutane-1,1-dicarboxylate)} was synthesized. The anticancer activity and toxicity were evaluated by comparing its interaction with DNA, cytotoxicity against four human cancer cell lines, antitumor efficiency in human gastric carcinoma NCI-N87 xenografts in nude mice, and preliminary side-effects in rats to those of its 4R,5R-optical isomer which is under preclinical development. Both isomers induce condensation of DNA to the same extent and have similar cytotoxicity, but show different antitumor activity and toxicity, probably owing to the difference in respective pharmacokinetic profiles. 4S,5S-Isomer seems to exhibit superior antitumor activity and less toxicity than 4R,5R-optical isomer as well as the parent heptaplatin. These results imply that 4S,5S-configuration as a new drug candidate may be better than 4R,5R-counterpart.",
        "keywords": [
            "anticancer activity",
            "derivative",
            "heptaplatin",
            "platinum complexes",
            "toxicity"
        ],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "State Key Laboratory for Platinum Group Metals, Kunming Institute of Precious Metals, 650106 Yunnan, PR China."
            },
            {
                "name": "Jing Jiang",
                "org": "State Key Laboratory for Platinum Group Metals, Kunming Institute of Precious Metals, 650106 Yunnan, PR China."
            },
            {
                "name": "Chengying Xie",
                "org": "Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, PR China."
            },
            {
                "name": "Shuqian Hou",
                "org": "State Key Laboratory for Platinum Group Metals, Kunming Institute of Precious Metals, 650106 Yunnan, PR China."
            },
            {
                "name": "Haitian Quan",
                "org": "Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, PR China."
            },
            {
                "name": "Qingsong Ye",
                "org": "State Key Laboratory for Platinum Group Metals, Kunming Institute of Precious Metals, 650106 Yunnan, PR China."
            },
            {
                "name": "Liguang Lou",
                "org": "Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, PR China."
            }
        ],
        "venue": "Journal of inorganic biochemistry",
        "year": 2014
    },
    "lw3stXHK": {
        "id": "lw3stXHK",
        "title": "Synthesis and Anticancer Activity of 3-chloro-1,1-dicarboxycyclobutane Diammine Platinum(II)",
        "abstract": "Platinum-based drugs are one of the most important anticancer drugs in clinical use.In this paper,a new platinum-based complex,3-chloro-1,1-dicarboxycyclobutane diammine platinum(II) was synthesized and its structures was characterized by element analysis,MS,IR,and 1H-NMR.The synthesized complex is confirmed to be the target compound.The IC50 of the compound is 4.8mg/L for A549 cell and 18.0 mg/L for KB cell respectively.",
        "keywords": [
            "pharmaceutical chemistry",
            "IC50",
            "structure characterization",
            "platinum-based complex",
            "synthesize"
        ],
        "authors": [
            {
                "name": "GAO Chuanzhu",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China;Kunming Guiyan Pharmaceutical Co.Ltd.,Kunming,Yunnan ,China"
            },
            {
                "name": "PU Shaoping",
                "org": "Kunming Guiyan Pharmaceutical Co.Ltd.,Kunming,Yunnan ,China;Kunming Science and Engineering University,Kunming,Yunnan ,China"
            },
            {
                "name": "LIU Weiping",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "GAO Wengui",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            }
        ],
        "venue": "Precious Metals",
        "year": 2007
    },
    "jcsJTKyc": {
        "id": "jcsJTKyc",
        "title": "A new orally active antidiabetic vanadyl complex--bis(alpha-furancarboxylato)oxovanadium(IV).",
        "abstract": "Bis(alpha-furancarboxylato)oxovanadium(IV)--a new orally active antidiabetic vanadyl complex has been synthesized, characterized, and tested for bioactivity as insulin-enhancing agents. The complex was administered intragastrically to both normal and STZ-diabetic rats for 4 weeks. The results show that the complex at a dose of 10.0 and 20.0 mg V kg(-1), could significantly lower the blood glucose level rats and ameliorated impaired glucose tolerance in STZ-diabetic, but not in normal rats. It was suggested that the complex exerted an antidiabetic effect in STZ-diabetic rats, which maybe was related to increasing the sensitivity to insulin.",
        "keywords": [],
        "authors": [
            {
                "name": "Mingjin Xie",
                "org": "Deparment of Chemistry, Nankai University, Tianjin 300071, PR China. yansp@nankai.edu.cn"
            },
            {
                "name": "Lihui Gao",
                "org": ""
            },
            {
                "name": "Ling Li",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Shiping Yan",
                "org": ""
            }
        ],
        "venue": "Journal of inorganic biochemistry",
        "year": 2005
    },
    "aYR8RNYx": {
        "id": "aYR8RNYx",
        "title": "Synthesis and Application of Acetylacetonate Platinum Group Metal Organic Complexes",
        "abstract": "Several kinds of acetylacetonate platinum metal organic complexes have been synthesized in our laboratory.In this paper,synthesis development and applications of acetylacetonate platinum metal organic complexes are briefly introduced.",
        "keywords": [
            "ligand chemistry",
            "application.",
            "acetylacetonate platinum metal organic complex",
            "synthesis"
        ],
        "authors": [
            {
                "name": "CHANG Qiaowen",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "LIU Weiping",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "ZHANG Ni",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "YE Qingsong",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "YU Yao",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "CHEN Xizhu",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "LIU Yang",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "LI Yunye",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            },
            {
                "name": "LI Chunying",
                "org": "Kunming Institute of Precious Metals,Kunming,Yunnan ,China"
            }
        ],
        "venue": "Precious Metals",
        "year": 2009
    },
    "e1ZlwZCT": {
        "id": "e1ZlwZCT",
        "title": "Antitumor Activity of the Carboplatin-\u03b1-Cyclodextrin Adduct",
        "abstract": "",
        "keywords": [
            "biomedical research",
            "bioinformatics"
        ],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Huizhou Xiong",
                "org": ""
            },
            {
                "name": "Yikun Yang",
                "org": ""
            },
            {
                "name": "Ling Li",
                "org": ""
            },
            {
                "name": "Zhiqiang Shen",
                "org": ""
            },
            {
                "name": "Zhihe Chen",
                "org": ""
            }
        ],
        "venue": "Metal-based Drugs",
        "year": 1997
    },
    "50Y89gDs": {
        "id": "50Y89gDs",
        "title": "Thermal Behavior of Palladium(II) Acetylacetonate",
        "abstract": "The palladium(II) acetylacetonate is an ideal precursor in preparing palladium films or coatings by chemical vapor deposition (CVD). Its thermal behavior has been investigated with TG-DTA and GC-MS under air and argon atmosphere. The results show that palladium(II) acetylacetonate sublime at 187\u2103 in air and 201\u2103 in Ar, and then decompose and recombine at higher temperature, forming different organic species, mainly 2,4-pentanedione in air and 2,4-pentanedione, 1-propen-2-ol acetate in Ar. By analysis above, it is suggested that air should be a better gas carrier than argon in the process of preparing palladium films by CVD with Pd(acac)2 as a precursor.",
        "keywords": [
            "GC-MS",
            "palladium(II) acetylacetonate",
            "TG-DTA",
            "thermal decomposition",
            "CVD"
        ],
        "authors": [
            {
                "name": "Liang Guang",
                "org": " Kunming Institute of Precious Metals, Kunming , China"
            },
            {
                "name": "Liu Weiping",
                "org": " Kunming Institute of Precious Metals, Kunming , China"
            },
            {
                "name": "Pu Shaoping",
                "org": " Kunming Institute of Precious Metals, Kunming , China"
            },
            {
                "name": "Yan Gexin",
                "org": " Kunming Institute of Precious Metals, Kunming , China"
            },
            {
                "name": "Hou Ying",
                "org": " Yunnan Reascend Science & Technology Co.,Ltd., Kunming , China"
            }
        ],
        "venue": "Rare Metal Materials and Engineering",
        "year": 2006
    },
    "WumRr7Yr": {
        "id": "WumRr7Yr",
        "title": "Preparation and characterization of the hydroxy-bridged dimeric-platinum compound",
        "abstract": "To prepare and characterize the hydroxyl-bridged dimeric platinum compound,a degradation product of cisplatin in aqueous solution.The compound was prepared via aquation of cisplatin,followed by irradiation at 313 nm.The chemical structures were characterized by elemental analysis,ESI-MS,1H NMR,along with X-ray crystal structure.The compound was determined to be a dimeric platinum(\u2161) complex with two hydroxyl groups as its bridged ligand.There are two expected Pt(\u2161) square planes.The angle formed between the planes is 2.7\u00b0,suggesting the two planes are actually in the same plane.The length of Pt-Pt is 3.095 and two nitrate ions lies outside the coordinated sphere.",
        "keywords": [
            "structure",
            "degradation product",
            "cisplatin",
            "synthesis",
            "aqueous solution"
        ],
        "authors": [
            {
                "name": "CHEN Xi-Zhu",
                "org": "Chemistry and Pharmacy Laboratory,Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "XIE Ming-Jin",
                "org": "School of Chemistry,Yunnan University,Kunming ,China"
            },
            {
                "name": "YE Qing-song",
                "org": "Chemistry and Pharmacy Laboratory,Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "LIU Wei-Ping",
                "org": "Chemistry and Pharmacy Laboratory,Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "YU Yao",
                "org": "Chemistry and Pharmacy Laboratory,Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "CHANG Qiao-wen",
                "org": "Chemistry and Pharmacy Laboratory,Kunming Institute of Precious Metals,Kunming ,China"
            },
            {
                "name": "HOU Shu-qian",
                "org": "Chemistry and Pharmacy Laboratory,Kunming Institute of Precious Metals,Kunming ,China"
            }
        ],
        "venue": "Journal of Yunnan University(Natural Sciences Edition)",
        "year": 2009
    },
    "hcKCV0PN": {
        "id": "hcKCV0PN",
        "title": "Cerebroprotective Effects of Dimeric Copper(II) Bis(o-acetoxybenzoate) on Ischemia-reperfusion Injury in Gerbils.",
        "abstract": "The cerebroprotective effects of copper aspirinate [dimeric copper(II) bis(o-acetoxybenzoate)] were investigated in gerbils subjected to 10-min global cerebral ischemia followed b 60-min reperfusion. The results showed that intragastric copper aspirinate (7.5, 15.0 and 30.0 mg Kg(-1)) markedly promoted the recovery of the electroencephalogram amplitude, attenuated the increase of lipid peroxide content and the decrease of superoxide dismutase activity in the cortex during ischemia-reperfusion injury. It suggested that copper aspirinate possesses potential neuroprotective properties, the mechanism of which might be related to an increase of the activity of endogenous superoxide dismutase.",
        "keywords": [
            "lipid peroxide",
            "electroencephalogram",
            "copper aspirinate",
            "antioxidant enzyme",
            "cerebral ischemia-reperfusion",
            "copper",
            "biomedical research",
            "bioinformatics"
        ],
        "authors": [
            {
                "name": "Ling Li",
                "org": ""
            },
            {
                "name": "Zhiqiang Shen",
                "org": ""
            },
            {
                "name": "Weimin Yang",
                "org": ""
            },
            {
                "name": "Wanling Wu",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Zhihe Chen",
                "org": ""
            }
        ],
        "venue": "Metal-based drugs",
        "year": 2002
    },
    "qi9D1Etk": {
        "id": "qi9D1Etk",
        "title": "Synthesis and anticancer activity of [2-hydroxy-1,3-diaminopropane-kappa 2N,N'] platinum(II) complexes.",
        "abstract": "A series of novel platinum(II) complexes involving a carrier with HO- peripheral functional group, 2-hydroxy-1,3-propanediamine (HO-pda), cis-[Pt(HO-dpa)X(2)] (X(2)=2Cl(-) (1), C(2)O(4)(2-) (2), malonate (3), 1,1-cyclobutane dicarboxylate (CBDCA) (4), 3-hydroxy-1,1-cyclobutanedicarboxylate (HO-CBDCA) (5)), have been synthesized and characterized by elemental analysis and spectroscopic data along with X-ray diffraction for three representative complexes 1, 4 and 5. The Pt(II) is in a square planar environment and is coordinated in cis position by a chelating HO-pda and 2Cl(-) for 1 and CBDCA for 4 and 5. Pt-N, Pt-Cl and Pt-O distances and coordinate bond angles of N-Pt-N, Cl-Pt-Cl and O-Pt-O are in the normal range. There are two independent molecules in the asymmetric unit of 5, held together by intermolecular hydrogen bonded chain. All the complexes show significant cytotoxicity on the sensitive cell lines SGC-7901, LNcap and A549, and are more active than carboplatin. 4 is also found to be active against the resistant cell A549/ATCC, which suggests that it has less cross-resistance with cisplatin than carboplatin. Moreover 4 shows much greater inhibition of tumor growth than carboplatin in S180-bearing mice, and is therefore worthy of further development as a potential anti-tumor platinum drug.",
        "keywords": [],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "Platinum-Based Drug Lab, Kunming Institute of Precious Metals, Kunming 650106, PR China. liuweiping0917@126.com"
            },
            {
                "name": "Xizhu Chen",
                "org": ""
            },
            {
                "name": "Mingjin Xie",
                "org": ""
            },
            {
                "name": "Liguang Lou",
                "org": ""
            },
            {
                "name": "Qingsong Ye",
                "org": ""
            },
            {
                "name": "Yao Yu",
                "org": ""
            },
            {
                "name": "Shuqian Hou",
                "org": ""
            }
        ],
        "venue": "Journal of inorganic biochemistry",
        "year": 2008
    },
    "wxL1C0e5": {
        "id": "wxL1C0e5",
        "title": "Synthesis, crystal structures and catalytic activity of tetrakis(acetato)dirhodium(II) complexes with axial picoline ligands",
        "abstract": "",
        "keywords": [
            "catalytic activity",
            "rhodium"
        ],
        "authors": [
            {
                "name": "qingsong ye",
                "org": ""
            },
            {
                "name": "xiaonian li",
                "org": ""
            },
            {
                "name": "yi jin",
                "org": ""
            },
            {
                "name": "juan yu",
                "org": ""
            },
            {
                "name": "qiaowen chang",
                "org": ""
            },
            {
                "name": "jing jiang",
                "org": ""
            },
            {
                "name": "caixian yan",
                "org": ""
            },
            {
                "name": "jie li",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            }
        ],
        "venue": "Inorganica Chimica Acta",
        "year": 2015
    },
    "vkOqxq6Z": {
        "id": "vkOqxq6Z",
        "title": "Bis(acetylacetonato-\u03ba 2 O , O \u2032)aqua(diacetylmethanido-\u03ba C )iridium(III)",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "qiaowen chang",
                "org": ""
            },
            {
                "name": "mingjin xie",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "xizhu chen",
                "org": ""
            },
            {
                "name": "qingsong ye",
                "org": ""
            }
        ],
        "venue": "Acta Crystallographica Section E-structure Reports Online",
        "year": 2009
    },
    "7OcKtsds": {
        "id": "7OcKtsds",
        "title": "To compare toxicity of a new platinum complax LLC-0601 with cisplatin and heptaplatin on L-02 cells and HK-2 cells in vitro",
        "abstract": "Objective To compare toxicity of a new platinum complax LLC-0601 with Cisplatin and heptaplatin on Human fetal liver cell(L-02) and human renal tubular epithelial cell(HK-2) in vitro.Methods L-02 cells and HK-2 cells were treated 48 hours with different concentrations of LLC-0601,cisplatin and heptaplatin,respectively,by MTT assays and calculated IC50.In addition,the concentrations of Lactic acid dehydrogenase(LDH) in cell culture fluid were measured by automatic biochemistry analyzer;morphological changes were observed.Results LLC-0601,cisplatin and heptaplatin treated two cells for 48 hours,at the same doses,the inhibition effect of LLC-0601 on L-02 cells and HK-2 cells were significantly lower than that of cisplatin and heptaplatin(P<0.05).Detected LDH levels of two cell culture fluid,LLC-0601 at higher doses to appeared the change of LDH,but cisplatin and heptaplatin at lower doses showed the increased LDH(P<0.05).Furthermore,the level of LDH in cisplatin treated was stronger than that of heptaplatin(P<0.05).Morphological changes showed that two cells by three platinum compounds treated appear vacuolar changes in the nucleus,cell membrane is not complete,and continued to increase drug concentration to cell death.Conclusion The toxicity of LLC-0601 on L-02 cell and HK-2 cell are significantly lower than that of cisplatin and heptaplatin in vitro.It is a potential compounds.",
        "keywords": [
            "LLC-0601",
            "Caplatin",
            "Toxicity",
            "Heptaplatin"
        ],
        "authors": [
            {
                "name": "WANG Zhen-yu",
                "org": "Center for Biomedical Engineering of Kunming Medical College,Kunming Yunnan ,China"
            },
            {
                "name": "MEI Rong",
                "org": "Center for Biomedical Engineering of Kunming Medical College,Kunming Yunnan ,China"
            },
            {
                "name": "SONG Jing-feng",
                "org": "Center for Biomedical Engineering of Kunming Medical College,Kunming Yunnan ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Center for Biomedical Engineering of Kunming Medical College,Kunming Yunnan ,China"
            },
            {
                "name": "DONG Rui-tao",
                "org": "Center for Biomedical Engineering of Kunming Medical College,Kunming Yunnan ,China"
            },
            {
                "name": "LU Ying",
                "org": "Center for Biomedical Engineering of Kunming Medical College,Kunming Yunnan ,China"
            }
        ],
        "venue": "Journal of Toxicology",
        "year": 2012
    },
    "R2OtVeRb": {
        "id": "R2OtVeRb",
        "title": "Bis(\u03b1-furancarboxylato)oxovanadium(IV) prevents and improves dexamethasone-induced insulin resistance in 3T3-L1 adipocytes",
        "abstract": "Previous studies showed that bis(\u03b1-furancarboxylato)oxovanadium(IV) (BFOV), an orally active antidiabetic organic vanadium complex, could improve insulin resistance in animals with type 2 diabetes. The present study has been carried out to evaluate the effects of BFOV on insulin-resistant glucose metabolism using dexamethasone-treated 3T3-L1 adipocytes as an in-vitro model of insulin resistance. The results showed that BFOV, similar to vanadyl sulfate and rosiglitazone, caused a concentration-dependent increase in glucose consumption by insulin-resistant adipocytes. Moreover, BFOV enhanced the action of insulin and completely prevented the development of insulin resistance induced by dexamethasone, leading to glucose consumption equal to that by normal cells. In addition, dexamethasone reduced the mRNA expression of insulin receptor substrate 1 (IRS-1) and glucose transporter 4 (GLUT4) in 3T3-L1 adipocytes, while BFOV normalized the expression of IRS-1 and GLUT4. These findings suggest that BFOV prevents and improves dexamethasone-induced insulin resistance in 3T3-L1 adipocytes by enhancing expression of IRS-1 and GLUT4 mRNA. \u00a9 2008 The Authors.",
        "keywords": [],
        "authors": [
            {
                "name": "Yi Qing Zuo",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Yanfen Niu",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "ChangFu Tian",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "Mingjin Xie",
                "org": "Yunnan University(Yunnan University),Kunming,China"
            },
            {
                "name": "Xizhu Chen",
                "org": "Kunming Institute of Precious Metals(Kunming Institute of Precious Metals,Institute of Precious Metals,Inst of Precious Metals),Kunming,China"
            },
            {
                "name": "Ling Li",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            }
        ],
        "venue": "Journal of Pharmacy and Pharmacology",
        "year": 2008
    },
    "4L1Eo3aV": {
        "id": "4L1Eo3aV",
        "title": "The influence of sodium and barium ions on the structures of iridium (III) acetylacetonate complexes",
        "abstract": "\nTwo iridium acetylacetonate complexes [Na(H2O)Ir(acac)2Cl2] n  (compound 1) and [Ba(H2O)5Ir(acac)2Cl2Ba(H2O)5][Ir(acac)2Cl2]3\u00b72H2O (compound 2) were synthesized and characterized by single-crystal X-ray diffraction, elemental analysis, NMR, IR, and absorption spectra. The influence of sodium and barium ions on their molecular structures was explored.",
        "keywords": [
            "Iridium acetylacetonate complexes",
            " Molecular structure",
            " Na+",
            " Ba2+",
            " Influence"
        ],
        "authors": [
            {
                "name": "qiaowen chang",
                "org": "kunming university of science and technology"
            },
            {
                "name": "caixian yan",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals,Kunming Institute of Precious Metals,Kunming,People\u2019s Republic of China"
            },
            {
                "name": "xiaonian li",
                "org": "chinese academy of sciences"
            },
            {
                "name": "hao cui",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals,Kunming Institute of Precious Metals,Kunming,People\u2019s Republic of China"
            },
            {
                "name": "qingsong ye",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals,Kunming Institute of Precious Metals,Kunming,People\u2019s Republic of China"
            },
            {
                "name": "jing jiang",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals,Kunming Institute of Precious Metals,Kunming,People\u2019s Republic of China"
            },
            {
                "name": "juan yu",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals,Kunming Institute of Precious Metals,Kunming,People\u2019s Republic of China"
            },
            {
                "name": "jialin chen",
                "org": "State Key Laboratory of Advanced Technologies for Comprehensive Utilization of Platinum Metals,Kunming Institute of Precious Metals,Kunming,People\u2019s Republic of China"
            },
            {
                "name": "weiping liu",
                "org": "kunming university of science and technology"
            }
        ],
        "venue": "Research on Chemical Intermediates",
        "year": 2014
    },
    "8HEcc69X": {
        "id": "8HEcc69X",
        "title": "Bis(<I>\u03b1</I>-furancarboxylato)oxovanadium(IV) prevents and improves dexamethasone-induced insulin resistance in 3T3-L1 adipocytes",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Yi-Qing Zuo",
                "org": ""
            },
            {
                "name": "Wei-Ping Liu",
                "org": ""
            },
            {
                "name": "Yan-Fen Niu",
                "org": ""
            },
            {
                "name": "Chang-Fu Tian",
                "org": ""
            },
            {
                "name": "Ming-Jin Xie",
                "org": ""
            },
            {
                "name": "Xi-Zhu Chen",
                "org": ""
            },
            {
                "name": "Ling Li",
                "org": ""
            }
        ],
        "venue": "Journal of Pharmacy and Pharmacology",
        "year": 2008
    },
    "M4viQPk4": {
        "id": "M4viQPk4",
        "title": "Experimental study of subsurface erosion in granitic under the conditions of different soil column angles and flow discharges",
        "abstract": "Soil erosion leads to soil loss and affects the hydraulic and mechanical properties of soils, and as a result, the soil fertility, eco-environmental quality, and reliability of engineering facilities will decline. Thus, it is very significant to study the mechanisms of subsurface erosion of granitic under different natural environmental conditions. However, limited studies focus on the effects of combined erosion angles and flow discharges on the subsurface erosion amount. This study self-made a subsurface erosion simulator and designed a series of combinational conditions of different soil column angles (0\u00b0, 30\u00b0, 60\u00b0) and different flow discharges (25 l/h, 50 l/h, 100 l/h) to simulate the subsurface erosion phenomenon and processes of moisture migration within granitic collected from a collapsing erosion area in southern China. Results show that the subsurface erosion development in the soil column is a complex and progressive process with obvious preferential flow, which indicates the transportability of soil particles, and the processes of soil subsurface erosion change markedly along with the change of soil column angle and flow discharge. Moreover, the growth rates of wetting front and subsurface erosion amount will speed up along with the increase of soil column angle of flow discharge. The relations between the advance rate of wetting front and time since the beginning of the test demonstrate bilinear. The erosion amount has obvious fluctuation during the process of subsurface erosion in granitic due to fine particles erosion, reposition, pore clogging, and flushing.",
        "keywords": "",
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "School of Civil Engineering and Architecture, Nanchang University, Nanchang, China"
            },
            {
                "name": "Shaofeng Wan",
                "org": "School of Civil Engineering and Architecture, Nanchang University, Nanchang, China"
            },
            {
                "name": "Faming Huang",
                "org": "School of Civil Engineering and Architecture, Nanchang University, Nanchang, China"
            },
            {
                "name": "Xiaoyan Luo",
                "org": "School of Civil Engineering and Architecture, Jiangxi Science and Technology Normal University, Nanchang, China"
            },
            {
                "name": "Mingfu Fu",
                "org": "School of Civil Engineering and Architecture, Nanchang Institute of Technology, Nanchang, China"
            }
        ],
        "venue": "Bulletin of Engineering Geology and the Environment",
        "year": 2019
    },
    "utJqYMfY": {
        "id": "utJqYMfY",
        "title": "Study on ultimate pulling force of anchor base on hyperbolic Mohr strength criterion",
        "abstract": "Base on the hyperbolic Mohr strength criterion and ultimate balance principle,the ultimate pulling force of the pre-stressed anchor was studied.The ultimate pulling force of the anchor would be influenced by the type of the rock and soil mass,shape of the cracking surface,grouting pressure,surrounding rock pressure and others.The study results showed that with the grouting pressure increased,the ultimate pulling force also would be increased.The results could provide the theoretical references to the application of the anchor project.",
        "keywords": [
            "ultimate pulling force",
            "hyperbolic strength envelope",
            "pre-stressed anchor"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "School of Civil Engineering and Architecture,Nanchang University,Nanchang ,China"
            },
            {
                "name": "FU Ming-fu",
                "org": "School of Civil Engineering and Architecture,Nanchang University,Nanchang ,China"
            },
            {
                "name": "LUO Xiao-yan",
                "org": "Jiangxi Technology Normal Collage,Nanchang ,China"
            },
            {
                "name": "HU Xiao-rong",
                "org": "School of Civil Engineering and Architecture,Nanchang University,Nanchang ,China"
            }
        ],
        "venue": "Coal Engineering",
        "year": 2010
    },
    "9wXMy6dr": {
        "id": "9wXMy6dr",
        "title": "Experiment and Modeling of Soil-WaterCharacteristic Curve of Unsaturated Soilin Collapsing Erosion Area",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Xiaoyan Luo",
                "org": ""
            },
            {
                "name": "Mingfu Fu",
                "org": ""
            },
            {
                "name": "Jinsong Huang",
                "org": ""
            }
        ],
        "venue": "Polish Journal of Environmental Studies",
        "year": 2016
    },
    "XUIObnnd": {
        "id": "XUIObnnd",
        "title": "Nonlocal Friction Analysis of Wholly Grouted Anchor",
        "abstract": "The nonlocal friction law proposed by Oden et al was modified and the modified nonlocal frica- tion model to analyze the wholly grouted anchor was used.Based on Mindlin's solution of displacement,an elastic solution of shear stress on bolt surface for wholly grouted anchor was derived.Wholly grouted an- chor was analyzed by using the modified nonlocal frication model,the nonlocal effect on the contact sur- face stress distribution was shown here and the solution of shear stress on bolt surface was given.The re- sults were compared with those obtained by the modified nonlocal frication model and local frication model and the experimental results in references.It is found that the result obtained by modified nonlocal frica- tion model coincides reasonably well with experimental results,and coincides better than the local frica- tion model.The result shows that the nonlocal friction law is more practicable.",
        "keywords": [
            "nonlocal frication",
            "wholly grouted anchor",
            "Mindlin's solution of displacement"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": " Jiangxi Technology Normal Collage,Nanchang ,China"
            },
            {
                "name": "FU Ming-fu",
                "org": " Jiangxi Technology Normal Collage,Nanchang ,China"
            },
            {
                "name": "LUO Xiao-yan",
                "org": " Jiangxi Technology Normal Collage,Nanchang ,China"
            }
        ],
        "venue": "Chinese Quarterly of Mechanics",
        "year": 2008
    },
    "saRXWEHh": {
        "id": "saRXWEHh",
        "title": "Analysis of compacting effects of tubular pile based on unified strength theory",
        "abstract": "Based on the unified strength theory and the cavity expansion theory,the compaction effects of the tubular pile are studied in this paper.The elasto-plastic analysis solution of the stress field and displacement field of the soil around the pile is given.The relationships between plastic zone,the limit expansion pressure,the radial stresses and the parameter b are also obtained from analysis.According to numerical results,the effect of intermediate principal stress on compaction effects of the tubular pile is examined.A comparative study is made for the present solution and other solutions based on Mohr-Coulomb criterion.The results show that the parameter b in unified strength theory has significant effects on the radius of plastic zone,the magnitude of stresses and displacement.The radius of plastic zone is decreased and the limit expansion pressure is increased,and at the same radius,the radial stress is also increased because of the effect of intermediate principal stress.",
        "keywords": [
            "tubular pile",
            "unified strength theory",
            "elasto-plastic analysis",
            "compacting effects"
        ],
        "authors": [
            {
                "name": "LUO Xiao-yan",
                "org": "Jiangxi Science and Technology Normal University,Nanchang ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "School of Civil Engineering and Architecture,Nanchang University,Nanchang ,China"
            }
        ],
        "venue": "Hydro-Science and Engineering",
        "year": 2011
    },
    "wwO1yqBp": {
        "id": "wwO1yqBp",
        "title": "Studies of kernel function in the nonlocal friction model and its application on bolt",
        "abstract": "To investigate the characteristics together with optimum selection of kernel functions in the nonlocal friction model, the nonlocal friction model proposed by Oden et al is modified. The kernel function in model is replaced by exponential function, trigonometric function, negative exponential function and power function. Based on the elastic solution of shear stress on bolt surface of the wholly grouted anchor derived with Mindlin's solution of displacement, wholly grouted anchor is analyzed by the modified nonlocal friction models which have four different kernel functions. The shear stress distributions on bolt surface given by the modified nonlocal friction models and the local friction models are similar. The nonlocal friction effect is also discussed. The results obtained by the modified nonlocal friction model with different kernel functions and local friction model are compared with experimental results. It is found that the calculating results obtained by modified nonlocal friction model with the negative exponential kernel functions agree better with experimental results.",
        "keywords": [
            "Bolt",
            "Kernel function",
            "Mindlin's solution of displacement",
            "Nonlocal frication"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "Nanchang University(Nanchang University),Nanchang,China"
            },
            {
                "name": "MingFu Mingfu",
                "org": "Nanchang University(Nanchang University),Nanchang,China"
            },
            {
                "name": "LUO Xiao-yan",
                "org": "School of Civil Engineering and Architecture(School of Civil Engineering and Architecture),,China"
            }
        ],
        "venue": "Beijing Gongye Daxue Xuebao/Journal of Beijing University of Technology",
        "year": 2011
    },
    "nLXNbHgp": {
        "id": "nLXNbHgp",
        "title": "The Numerical and Emulational Analysis of the Relation between Loads and Sedimentations of the Rock-socketed Filling Pile",
        "abstract": "In this paper,a two dimensional model between the rock-socketed filling pile and the soil is established by using the PLANE42 CONTACT171 and TARGET169 in ANSYS. Then we can get different sedimentations under the condition of different loads and eventually draw the Q-S curve after calculation.Comparison between the results obtained by the proposed method and the measured data is made;and close agreement has been found.It is shown that the proposed method is theoretically reliable,simple in application and useful in practice.",
        "keywords": [
            "Q-S curve",
            "numerical and emulational analysis",
            "ANSYS",
            "rock-socketed filling pile"
        ],
        "authors": [
            {
                "name": "ZHA Jin-bo",
                "org": "School of Architectural Engineering,Nanchang University,Nanchang ,China"
            },
            {
                "name": "HUANG Min",
                "org": "School of Architectural Engineering,Nanchang University,Nanchang ,China"
            },
            {
                "name": "FU Ming-fu",
                "org": "School of Architectural Engineering,Nanchang University,Nanchang ,China"
            },
            {
                "name": "LIU Wei-Ping",
                "org": "School of Architectural Engineering,Nanchang University,Nanchang ,China"
            }
        ],
        "venue": "Journal of Nanchang University(Engineering & Technology)",
        "year": 2006
    },
    "HS6xVTbu": {
        "id": "HS6xVTbu",
        "title": "Stability Analysis of Hydrodynamic Pressure Landslides with Different Permeability Coefficients Affected by Reservoir Water Level Fluctuations and Rainstorms",
        "abstract": "It is significant to study the variations in the stability coefficients of hydrodynamic pressure landslides with different permeability coefficients affected by reservoir water level fluctuations and rainstorms. The Sifangbei landslide in Three Gorges Reservoir area is used as case study. Its stability coefficients are simulated based on saturated-unsaturated seepage theory and finite element analysis. The operating conditions of stability coefficients calculation are reservoir water level variations between 175 m and 145 m, different rates of reservoir water level fluctuations, and a three-day continuous rainstorm. Results show that the stability coefficient of the hydrodynamic pressure landslide decreases with the drawdown of the reservoir water level, and a rapid drawdown rate leads to a small stability coefficient when the permeability coefficient ranges from 1.16 \u00d7 10\u22126 m/s to 4.64 \u00d7 10\u22125 m/s. Additionally, the landslide stability coefficient increases as the reservoir water level increases, and a rapid increase in the water level leads to a high stability coefficient when the permeability coefficient ranges from 1.16 \u00d7 10\u22126 m/s to 4.64 \u00d7 10\u22125 m/s. The landslide stability coefficient initially decreases and then increases as the reservoir water level declines when the permeability coefficient is greater than 4.64 \u00d7 10\u22125 m/s. Moreover, for structures with the same landslide, the landslide stability coefficient is most sensitive to the change in the rate of reservoir water level drawdown when the permeability coefficient increases from 1.16 \u00d7 10\u22126 m/s to 1.16 \u00d7 10\u22124 m/s. Additionally, the rate of decrease in the stability coefficient increases as the permeability coefficient increases. Finally, the three-day rainstorm leads to a significant reduction in landslide stability, and the rate of decrease in the stability coefficient initially increases and then decreases as the permeability coefficient increases.",
        "keywords": "",
        "authors": [
            {
                "name": "Faming Huang",
                "org": ""
            },
            {
                "name": "Xiaoyan Luo",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            }
        ],
        "venue": "Water",
        "year": 2017
    },
    "XVBKu8kR": {
        "id": "XVBKu8kR",
        "title": "Test Investigation on Characteristic of Bearing Capacity of Large Diameter Manually Excavated Belled Piles",
        "abstract": "Based on data from reinforcing steel bar stress transducer and pressure transducer embedded in the different layers of piles through field static loading test of three piles,the paper analyzes the characteristic of bearing capacity and load transfer mechanism of the manually excavated belled piles,problems about the action laws of pile end resistance and lateral fricrtion resistance and shaft compression are also discussed.The load-bearing capacity of gravel sands reaches 3.65 MPa.And some important references for the theoretical research and technical application of manually excavated belled Piles in the region are provided.",
        "keywords": [
            "manually excavated belled piles",
            "characteristic of bearing capacity",
            "static loading test"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "School of Architectural Engineering,Nanchang University,Nanchang ,China"
            },
            {
                "name": "FU Ming-fu",
                "org": "School of Architectural Engineering,Nanchang University,Nanchang ,China"
            },
            {
                "name": "LUO Xiao-yan",
                "org": "Jiangxi,Science & Technology Normal College,Nanchang ,China"
            },
            {
                "name": "ZENG Xian-kun",
                "org": "Nanchang Engineering & Research Institute of Nonferrous Metals,Nanchang ,China"
            }
        ],
        "venue": "Journal of Nanchang University(Engineering & Technology)",
        "year": 2006
    },
    "245etG51": {
        "id": "245etG51",
        "title": "Probabilistic Analysis of Tunnel Face Stability below River Using Bayesian Framework",
        "abstract": "A key issue in assessment on tunnel face stability is a reliable evaluation of required support pressure on the tunnel face and its variations during tunnel excavation. In this paper, a Bayesian framework involving Markov Chain Monte Carlo (MCMC) simulation is implemented to estimate the uncertainties of limit support pressure. The probabilistic analysis for the three-dimensional face stability of tunnel below river is presented. The friction angle and cohesion are considered as random variables. The uncertainties of friction angle and cohesion and their effects on tunnel face stability prediction are evaluated using the Bayesian method. The three-dimensional model of tunnel face stability below river is based on the limit equilibrium theory and is adopted for the probabilistic analysis. The results show that the posterior uncertainty bounds of friction angle and cohesion are much narrower than the prior ones, implying that the reduction of uncertainty in cohesion and friction significantly reduces the uncertainty of limit support pressure. The uncertainty encompassed in strength parameters are greatly reduced by the MCMC simulation. By conducting uncertainty analysis, MCMC simulation exhibits powerful capability for improving the reliability and accuracy of computational time and calculations.",
        "keywords": "",
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "School of Civil Engineering and Architecture, Nanchang University, Nanchang 330031, China"
            },
            {
                "name": "Xiaoyan Luo",
                "org": "Jiangxi Science and Technology Normal University, Nanchang 330013, China"
            },
            {
                "name": "Jinsong Huang",
                "org": "ARC Centre of Excellence for Geotechnical Science and Engineering, University of Newcastle, Callaghan, NSW 2308, Australia"
            },
            {
                "name": "Lina Hu",
                "org": "School of Civil Engineering and Architecture, Nanchang University, Nanchang 330031, China"
            },
            {
                "name": "Mingfu Fu",
                "org": "School of Civil Engineering and Architecture, Nanchang University, Nanchang 330031, China"
            },
            {
                "name": "Mingfu Fu",
                "org": "School of Civil Engineering and Architecture, Nanchang University, Nanchang 330031, China"
            }
        ],
        "venue": "Mathematical Problems in Engineering",
        "year": 2018
    },
    "ItNQ8QHY": {
        "id": "ItNQ8QHY",
        "title": "Analysis of driving effect of tubular pile based on two-parameter parabolic failure envelope",
        "abstract": "Based on the hypothesis that the pile driving process is regarded as cavity expansion,according to two-parameter parabolic failure envelope and the cavity expansion theory,the driving effect of the tubular pile is studied.The elasto-plastic analysis solution of the stress field and displacement field of the soil around the pile are given.The radius of plastic zone and the limit expansion pressure are obtained.It can provide theoretical supports for some tubular pile engineering practices.",
        "keywords": [
            "tubular pile",
            "elasto-plastic analysis",
            "two-parameter parabolic failure envelope",
            "effect of pile driving"
        ],
        "authors": [
            {
                "name": "LIU Weiping",
                "org": "School of Civil Engineering and Architecture,Nanchang University,Nanchang ,China"
            },
            {
                "name": "FU Mingfu",
                "org": "School of Civil Engineering and Architecture,Nanchang University,Nanchang ,China"
            },
            {
                "name": "HU Xiaorong",
                "org": "School of Civil Engineering and Architecture,Nanchang University,Nanchang ,China"
            }
        ],
        "venue": "Coal Geology & Exploration",
        "year": 2010
    },
    "Kf5M2Ht0": {
        "id": "Kf5M2Ht0",
        "title": "Elastoplastic analysis of tunnels based on parabolic Mohr strength criterion",
        "abstract": "Based on the Mohr strength criterion with parabolic failure envelope,an elastoplastic analysis of tunnels under seepages was given.Comparative analysis of an example with and without consideration of seepages indicates that the radius of the plastic zone considering influence of seepage fields is larger than that without considering it.With the increase of the pore water pressure,the influence of seepage fields is more and more significant.The seepage fields have close relation with the radial and tangential stresses of the tunnels.It may provide theoretical supports for the design of tunnels whose strength envelopes similarly take the form of quadratic parabolas.",
        "keywords": [
            "elastoplastic analysis",
            "seepage field",
            "parabolic Mohr strength criterion",
            "tunnel"
        ],
        "authors": [
            {
                "name": "LUO Xiao-yan",
                "org": "School of Civil Engineering and Architecture,Jiangxi Science and Technology Normal University,Nanchang ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "School of Civil Engineering and Architecture,Nanchang University,Nanchang ,China"
            }
        ],
        "venue": "Advances in Science and Technology of Water Resources",
        "year": 2011
    },
    "DTmuBPaS": {
        "id": "DTmuBPaS",
        "title": "Deformation analysis of tension pile based on nonlocal frication law",
        "abstract": "The nonlocal friction model proposed by Oden et al is modified on the basis of the geometric model of the tension pile.The deformation of tension pile is analyzed by using the modified nonlocal frication model,and the nonlocal effect of the contact surface on stress distribution is presented in the paper.A comparison of the analysis results from different models shows that the nonlocal friction law is feasible and reliable.",
        "keywords": [
            "geometric model",
            "tension pile",
            "nonlocal frication",
            "deformation"
        ],
        "authors": [
            {
                "name": "LIAO Xiaohong",
                "org": "School of Architectural Engineering,Nanchang University,Nanchang "
            },
            {
                "name": "FU Mingfu",
                "org": "President's Office,Nanchang Institute of Technology,Nanchang ,China"
            },
            {
                "name": "LIU Weiping",
                "org": "School of Architectural Engineering,Nanchang University,Nanchang "
            }
        ],
        "venue": "Journal of Nanchang Institute of Technology",
        "year": 2010
    },
    "2NfJ5rRR": {
        "id": "2NfJ5rRR",
        "title": "Nonlocal friction analysis of prestressed cables",
        "abstract": "In this paper, based on Kelvin's solution of displacement, a solution of shear stress in the anchorage is derived. The nonlacol friction law proposed by Oden et al is used to analyze the prestressed cables. The integral form of shear stress is obtained and solved by programming Maple language. The nonlocal effect on the contact surface stress distribution is shown here and the solution of shear stress is given. The results are compared with those obtained by the nonlocal frication model and local frication model. The factors which affect the nonlocal friction effect are discussed. The results also show that nonlocal effect changes with rock hardness and nonlocal effect size.",
        "keywords": [
            "mechanical analysis",
            "prestressed cable",
            "nonlocal friction",
            "non-local infection coefficient"
        ],
        "authors": [
            {
                "name": "LIU Weiping",
                "org": " School of Civil Engineering and Architecture, Nanchang University, Nanchang , China"
            },
            {
                "name": "FU Mingfu",
                "org": " School of Civil Engineering and Architecture, Nanchang University, Nanchang , China"
            },
            {
                "name": "LUO Xiaoyan",
                "org": " Jiangxi Technology Normal Collage, Nanchang , China"
            }
        ],
        "venue": "Coal Geology & Exploration",
        "year": 2009
    },
    "97AyvuAz": {
        "id": "97AyvuAz",
        "title": "Analysis on Non-local Friction of Pressure Type Anchor Cable",
        "abstract": "Stressing state of anchoring section of pressure anchor cable is analyzed using non-local friction model advanced by Oden instead of the classic Coulomb friction model.Balance equation of the stress is established and its solution is solved using perturbation method.Through comparison between shearing strength and axial force under non-local friction model and Coulomb friction model,correlative factors to non-local effect are analyzed.",
        "keywords": [
            "pressure anchor cable",
            "mechanical analysis",
            "non-local friction"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "School of Architectural Engineering,Nanchang University,Nanchang ,China"
            },
            {
                "name": "FU Ming-fu",
                "org": "School of Architectural Engineering,Nanchang University,Nanchang ,China"
            }
        ],
        "venue": "Subgrade Engineering",
        "year": 2010
    },
    "vwim529a": {
        "id": "vwim529a",
        "title": "Face Stability Analysis of Shield Tunnel Using Slip Line Method",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "School of Civil Engineering and Architecture, Nanchang University, Nanchang 330031, China"
            },
            {
                "name": "Shaofeng Wan",
                "org": "School of Civil Engineering and Architecture, Nanchang University, Nanchang 330031, China"
            },
            {
                "name": "Xinqiang Song",
                "org": "School of Civil Engineering and Architecture, Nanchang University, Nanchang 330031, China"
            },
            {
                "name": "Mingfu Fu",
                "org": "School of Civil Engineering and Architecture, Nanchang Institute of Technology, Nanchang 330099, China"
            },
            {
                "name": "Lina Hu",
                "org": "School of Civil Engineering and Architecture, Nanchang University, Nanchang 330031, China"
            }
        ],
        "venue": "Mathematical Problems in Engineering",
        "year": 2019
    },
    "yRfvb1kQ": {
        "id": "yRfvb1kQ",
        "title": "Prediction of soil water retention curve using Bayesian updating from limited measurement data",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "School of Civil Engineering and Architecture, Nanchang University, Nanchang 330031, China"
            },
            {
                "name": "Xiaoyan Luo",
                "org": "School of Civil Engineering and Architecture, Nanchang University, Nanchang 330031, China"
            },
            {
                "name": "Faming Huang",
                "org": "School of Civil Engineering and Architecture, Nanchang University, Nanchang 330031, China"
            },
            {
                "name": "Mingfu Fu",
                "org": "School of Civil Engineering and Architecture, Nanchang Institute of Technology, Nanchang 330099, China"
            }
        ],
        "venue": "Applied Mathematical Modelling",
        "year": 2019
    },
    "gm4fjcFX": {
        "id": "gm4fjcFX",
        "title": "Probabilistic analysis of soil-water characteristic curve with Bayesian approach and its application on slope stability under rainfall via a difference equations approach",
        "abstract": "The soil-water characteristic curve (SWCC) is an important tool in the interpretation of the properties of unsaturated soil, and is widely applied in Geotechnical and Geo-environmental engineering. The SWCC uses several fitting parameters to express the best fit equations, and the fitting parameters depend on the experimental data. The reliability and predictability of SWCC are always being questioned. In this paper, Fredlund and Xing model is used to fit the experimental data of loamy sand and sandy clay loam in the UNSODA database, the fitting parameters values are discussed. Bayesian framework and the Markov Chain Monte Carlo simulation method are applied to estimate the uncertainty of SWCC from the errors and variance of the fitting parameters, and SWCC of different levels of confidence is obtained. Applications of the confidence on slope stability analysis are presented by a simplified finite element program.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaoyan Luo",
                "org": "School of Civil Engineering and Architecture, Nanchang University, Nanchang, China.; School of Civil Engineering and Architecture, Jiangxi Science and Technology Normal University, Nanchang, China."
            },
            {
                "name": "Weiping Liu",
                "org": "School of Civil Engineering and Architecture, Nanchang University, Nanchang, China."
            },
            {
                "name": "Mingfu Fu",
                "org": "School of Civil Engineering and Architecture, Nanchang University, Nanchang, China."
            },
            {
                "name": "Jinsong Huang",
                "org": "CGSE, University of Newcastle, Callaghan, Australia."
            }
        ],
        "venue": "Journal of Difference Equations and Applications",
        "year": 2017
    },
    "EI4f7eqN": {
        "id": "EI4f7eqN",
        "title": "Elastoplastic stress analysis of pressure tunnel based on improvement of unified strength criterion",
        "abstract": "Based on the unified strength criterion with parabolic failure envelope, the nonlinear improved expression of the two-parameter twin shear unified criterion is obtained. Elastoplastic analysis of pressure tunnels is presented by considering the seepage and intermediate principal stress. The results show that the intermediate principalstress parameter b in unified strength theory has significant effect on the radius of plastic zone. The radius of plastic zone is decreased along with the increase of the intermediate principal stress parameter b. An example is analyzed and contrasted with and without considering seepage. The radius of plastic zone with considering influence of seepage is larger than that without considering the seepage influence. The results also indicate that the parameter b and seepage have significant influences on tangential stress and radial stress. The results obtained by the original linear expression and the nonlinear improved expression of the two-parameter twin shear unified strength theory are large difference. In tunnel design, the unified strength theory parameter should be reasonably adopted according to surrounding rock material properties. So as to provide theoretical supports for tunnel design.",
        "keywords": [
            "Parabolic failure envelope",
            "Pressure tunnel",
            "Seepage",
            "Unified strength criterion"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "Nanchang University(Nanchang University),Nanchang,China"
            },
            {
                "name": "LUO Xiao-yan",
                "org": "Jiangxi Science and Technology Normal University(Jiangxi University of Science and Technology,Jiangxi Science and Technology Normal University),Nanchang Economic and Technology Developing Zone,China"
            },
            {
                "name": "HU Xiao-rong",
                "org": "Nanchang University(Nanchang University),Nanchang,China"
            },
            {
                "name": "MingFu Mingfu",
                "org": "Nanchang University(Nanchang University),Nanchang,China"
            }
        ],
        "venue": "Yantu Lixue/Rock and Soil Mechanics",
        "year": 2011
    },
    "mmGR76Ds": {
        "id": "mmGR76Ds",
        "title": "Analysis of driving effect of tubular pile based on hyperbolic failure envelope",
        "abstract": "Based on the hypothesis that the pile driving process is regarded as round expansion,according to hyperbolic failure envelope and the cavity expansion theory,the driving effect of the tubular pile is studied.The elasto-plastic analysis solution of the stress field and displacement field of the soil around the pile are given.The radius of plastic zone and the limit expansion pressure are obtained.",
        "keywords": [
            "tubular pile",
            "elasto-plastic analysis",
            "effect of pile driving",
            "hyperbolic failure envelope"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "School of Civil Engineering and Architecture,Nanchang University,Nanchang ,China"
            },
            {
                "name": "FU Ming-fu",
                "org": "School of Civil Engineering and Architecture,Nanchang University,Nanchang ,China"
            },
            {
                "name": "HU Xiao-rong",
                "org": "School of Civil Engineering and Architecture,Nanchang University,Nanchang ,China"
            }
        ],
        "venue": "Port & Waterway Engineering",
        "year": 2010
    },
    "Wnkja6cF": {
        "id": "Wnkja6cF",
        "title": "Test Research on the Torsion Moment on the Scene of High-strength Bolts on the Structure",
        "abstract": "Having analyzed the check result of the torsional moment on the scene of the big hexangular high-stength bolts conjuncted in the service based on the engineering example,the paper gives two reseans about the lose of pretension:the earlier checking of the moment and the inaccurate maintenance method.For reducing the disadvantageous influence of the the relaxation of strain and the lose of pretension on the structure,the time span of delaying scene torsional moment checx and accurate maintence method are given.",
        "keywords": [
            "pretension",
            "high-strength bolts",
            "torsion moment on the scene"
        ],
        "authors": [
            {
                "name": "CHENG Shu-li",
                "org": "School of Architectural Engineering,Nanchang University,Nanchang ,China"
            },
            {
                "name": "FU Ming-fu",
                "org": "School of Architectural Engineering,Nanchang University,Nanchang ,China"
            },
            {
                "name": "YUAN Zhi-jun",
                "org": "School of Architectural Engineering,Nanchang University,Nanchang ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "School of Architectural Engineering,Nanchang University,Nanchang ,China"
            }
        ],
        "venue": "Journal of Nanchang University(Engineering & Technology)",
        "year": 2007
    },
    "mt1xvRTC": {
        "id": "mt1xvRTC",
        "title": "A Study on the Hypothesis of Forest Carbon Emissions Trading",
        "abstract": "The background of that forest enters carbon emissions market was expounded.Four hypothesis which make forest produced carbon emission right reasonable were pointed and analyzed.There are the negative effect be bigger than the positive effect of climate warmer,the main reason of climate warmer be the carbon dioxide increased,the technology of carbon capture be continuous,and the forest be manage to be the carbon sink.",
        "keywords": [
            "forest carbon emissions trading",
            "hypothesis",
            "climate change"
        ],
        "authors": [
            {
                "name": "FENG Liang-ming",
                "org": "Economics and Management Academic of Fujian Agriculture and Forestry University,Fuzhou,fujian  China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Economics and Management Academic of Fujian Agriculture and Forestry University,Fuzhou,fujian  China"
            }
        ],
        "venue": "Problems of Forestry Economics",
        "year": 2007
    },
    "k5KdP6l6": {
        "id": "k5KdP6l6",
        "title": "Analysis of Economic Benefits of PVP to Producers and Consumers",
        "abstract": "By building an economic model including seed market and product market of new plant varieties and by means of static analysis and comparative static analysis,study is made on the economic benefits of plant variety protection(PVP) to producers and consumers.Some conclusions are put forward as follows: First,PVP can take the positive economic surplus to consumers,but whether it is positive to take the economic surplus to producers can not be certain;Second,the lever of PVP is negative to the consumers' economic surplus and total economic surplus of consumers and producers,but whether the relationship between the lever of PVP and the producers' economic surplus is positive or negative can not be certain.",
        "keywords": [
            "plant breeding right(PBR)",
            "economic benefit",
            "plant variety protection(PVP)"
        ],
        "authors": [
            {
                "name": "HUANG Xiu-juan",
                "org": "Economics and Management College,Fujian Agriculture and Forestry University,Fuzhou "
            },
            {
                "name": "WU Li-zeng",
                "org": "Agricultural Division,Fujian Provincial Department of Science and Technology,Fuzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Economics and Management College,Fujian Agriculture and Forestry University,Fuzhou "
            }
        ],
        "venue": "Journal of Northwest A&F University(Social Science Edition)",
        "year": 2009
    },
    "DYZV4Tp7": {
        "id": "DYZV4Tp7",
        "title": "Forestry resources assetization management and system innovation of forestry resources cultivation fund",
        "abstract": "The relationship between forestry resources assetization management(FRAM) and system innovation of forestry resources' cultivation fund(FRCF) is stated,indicating that FRCF,forest price and the fee of forest cultivation all are characterized as compensation to the cost of forest management,and that FRCF is actually the reproduction fund of forestry resources.In the end of this paper the problems and the train of thought for the system innovation of FRCF are stated when the FARM is actualised.",
        "keywords": [
            "System of forestry resources' cultivation fund",
            "Assetization management",
            "Innovation",
            "Forest resources"
        ],
        "authors": [
            {
                "name": "WEI Yuan-Zhu",
                "org": "Economics and Management College,Fujian Agriculture and Forestry University,Fuzhou ,China"
            },
            {
                "name": "CHEN Qin",
                "org": "Economics and Management College,Fujian Agriculture and Forestry University,Fuzhou ,China"
            },
            {
                "name": "LIU Wei-Ping",
                "org": "Economics and Management College,Fujian Agriculture and Forestry University,Fuzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Eco-Agriculture",
        "year": 2006
    },
    "SCyVxXBu": {
        "id": "SCyVxXBu",
        "title": "The Situation and Analysis of Foreign and Domestic Apicultural Policy",
        "abstract": "At present, China is seeing very significant bottlenecks for apiculture. The development of Chinese beekeeping cannot be separated from the concern and support of the government. The paper conducted a systematic review of foreign and domestic apicultural policies. Furthermore, the paper provided six suggestions about the combination of special assistance and auxiliary support, supporting the beekeeping cooperative organizations,and so on.",
        "keywords": [
            "support policy",
            "Apiculture",
            "pollination"
        ],
        "authors": [
            {
                "name": "Li Haiyan",
                "org": "Economic and Management College of Fujian Agriculture and Forestry University, Fuzhou ;Bee Research Institute, Chinese Academy of Agricultural Sciences, Beijing "
            },
            {
                "name": "Liu Weiping",
                "org": "Economic and Management College of Fujian Agriculture and Forestry University, Fuzhou "
            }
        ],
        "venue": "Apiculture of China",
        "year": 2012
    },
    "UphFjZph": {
        "id": "UphFjZph",
        "title": "MECHANISM ANALYSIS OF THE IMPACT OF BIOMASS ENERGY DEVELOPMENT ON FOOD SECURITY IN FUJIAN PROVINCE",
        "abstract": "On the prospective of food security,the paper analyzed the biomass energy,a new industry,in Fujian.Firstly impacts of the development of biomass energy on food and energy security were considered,and then,by using methods of the cobweb model,granger causality,and ECM model,the long-term causality between corn prices and ethanol prices was evaluated.Finally,how the development of biomass energy affected food and energy security was discussed.",
        "keywords": [
            "biomass energy",
            "food security",
            "mechanism analysis",
            "impact"
        ],
        "authors": [
            {
                "name": "Liu Feixiang",
                "org": "College of crop science,Fujian Agriculture and Forestry University U"
            },
            {
                "name": "Liu Weiping",
                "org": "College of economics and management,Fujian Agriculture and Forestry University,Fuzhou Fujian "
            }
        ],
        "venue": "Chinese Journal of Agricultural Resources and Regional Planning",
        "year": 2011
    },
    "NR4xyuT5": {
        "id": "NR4xyuT5",
        "title": "Research on the Contribution of Forestry Food in Human Nutrition Structure",
        "abstract": "Forestry food can not only complements the diversity of food,but also provides high-quality food and improve food security of humanity.In the paper,human food sources are divided into arable agriculture,animal husbandry,fishery and forestry food.Through the collection of the world production data of 2007of all food sources,the paper calculates the number of energy,protein,fat and other important nutrient elements provided by various types of food,based on the food nutrient composition tables,and draw a conclusion that the energy,protein and fat which forestry food contributes to human is 8.5%,2.48% and 5.01% respectively,which can quantitatively analyzes the contribution of the forestry food in human nutrition structure.Then the paper briefly analyzes the problems and trends of the development of the world's forestry food.",
        "keywords": [
            "food composition",
            "nutrient element",
            "forestry food"
        ],
        "authors": [
            {
                "name": "HONG Yan-zhen",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            },
            {
                "name": "DAI Yong-wu",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            }
        ],
        "venue": "Issues of Forestry Economics",
        "year": 2009
    },
    "UrPNGSWM": {
        "id": "UrPNGSWM",
        "title": "Analysis on the Structural Changes in the Production and Trade of World Main Woody Grain",
        "abstract": "The paper analyzes the changes in the production and trade of world\ue6afs major woody food in the past 50 years,based on the relevant data from FAOSTAT database.The results show that:Although the total harvest area and the annual output of the main woody food in the world have increased,but the annual production slowly grow,and the yield per unit area decline in.China and the Middle East countries have an important contribution to the production expansion of the world\ue6afs main woody food,but developed countries such as Japan and Italy,reduce the production scale of woody food.The export volume of main woody food in the world is small,the export growth has been slow.Chinese chestnut and persimmon production is high,but the international competitiveness is not strong.The major countries which import woody food from the world are little changed,still mainly in Japan,France and the United States and other developed countries.",
        "keywords": [
            "product",
            "structure",
            "trade",
            "woody grain"
        ],
        "authors": [
            {
                "name": "DAI Yong-wu",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            },
            {
                "name": "HONG Yan-zhen",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            },
            {
                "name": "DAI Ke-wei",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            },
            {
                "name": "CHEN Mei-ying",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            }
        ],
        "venue": "Issues of Forestry Economics",
        "year": 2012
    },
    "vQwbRVgW": {
        "id": "vQwbRVgW",
        "title": "Analysis on Scale Efficiency of Tobacco Cultivation and Influence Factors:Taking Fujian Province as a case",
        "abstract": "Developing modern tobacco agriculture can promote tobacco continuous improvement and meet strong desires of tobacco farmers.Scale cultivation is the only road to develop modern tobacco agriculture.The model to evaluate scale efficiency of tobacco cultivation for tobacco farmers was established by DEA-Tobit two-stage method based on survey data to explore inner change regulation and influence factors of scale efficiency in tobacco cultivation.The results showed that the super-scale cultivation pattern was inapplicability because of decreasing returns to super-scale cultivation.Therefore,the local appropriate scale cultivation standard should be determined according to the evaluation result of local scale cultivation efficiency.Five factors affecting scale cultivation efficiency of tobacco farmers were age,education degree,income from non-tobacco,self-support land and rent of tobacco field.The quality promotion of tobacco farmers should be paid more attention to especially.",
        "keywords": [
            "tobacco farmer",
            "tobacco",
            "influence factor",
            "two-stage method",
            "scale efficiency"
        ],
        "authors": [
            {
                "name": "ZHANG Hong-yong",
                "org": "College of Economy and Management,Fujian Agriculture and Forestry University,Fuzhou,Fujian ;China National Tobacco Corporation Fujian Tobacco Company,Chinese Tobacco Corporation,Fujian ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "College of Economy and Management,Fujian Agriculture and Forestry University,Fuzhou,Fujian "
            }
        ],
        "venue": "Guizhou Agricultural Sciences",
        "year": 2011
    },
    "CfrJvSsd": {
        "id": "CfrJvSsd",
        "title": "Discussion on Ecological Benefits Compensation Funds Assignation of Non-commercial Forest",
        "abstract": "It is favorable for non-commercial forest protection to assign compensation funds fairly and reasonably. Firstly,author expounds allocation principle of compensation funds. Secondly,it is demonstrated and analyzed by equity,property right,public goods and external economy theory at present that compensation funds assignation of non-commercial forest is unfair,and that owner of non-commercial forest does not obtain income of property right in China. Government must solve the question. Thirdly,the author discusses influence factors of compensation funds allocation,including cost,quality,demand degree,importance degree,area,loss of non-commercial forest and so on. Finally,the paper expounds account method of compensation funds assignation standard. Author put forward that compensation funds assignation standard of state non-commercial forest is ascertained by cost account,and that the standard of other non-commercial forest is ascertained by loss account. Therefore,it is necessary to establish fair and reasonable assignation mechanism of compensation funds in order to inspirit construction and protection of non-commercial forest,and improve environment.",
        "keywords": [
            "compensation funds",
            "ecological benefits",
            "assignation",
            "non-commercial forest"
        ],
        "authors": [
            {
                "name": "Chen Qin",
                "org": "Economy and Management College of Fujian Agriculture and Forestry University,Fuzhou "
            },
            {
                "name": "Liu Weiping",
                "org": "Economy and Management College of Fujian Agriculture and Forestry University,Fuzhou "
            }
        ],
        "venue": "Chinese Agricultural Science Bulletin",
        "year": 2008
    },
    "uryqcLqg": {
        "id": "uryqcLqg",
        "title": "Study on the Forest Traveling Resources Assessment Method Contrast Analysis",
        "abstract": "This article contrasts and summaries the existing forest traveling resources assessment method.Through forest scenic resources assessment method,forest traveling resources economic evaluation as well as forest traveling resources quality synthetic evaluation method to analyze,then analyze each method the advantages and the applicable scope,then provide the certain reference for the later appraisal work.",
        "keywords": [
            "forest traveling resources assessment",
            "forest traveling resources",
            "assessment method"
        ],
        "authors": [
            {
                "name": "ZHAO Hong-xia",
                "org": "Management and Economy College of Fujian Agriculture and Forestry University,Fuzhou  China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Management and Economy College of Fujian Agriculture and Forestry University,Fuzhou  China"
            }
        ],
        "venue": "Problems of Forestry Economics",
        "year": 2006
    },
    "agEPJN2L": {
        "id": "agEPJN2L",
        "title": "Analysis on Biopiracy and Contradiction with the Protecting of Gene Resource",
        "abstract": "Analyze some representative event of biopiracy,it summarized the reason of biopiracy and the impact on the present property right.Some measures are put forward to interdict biopiracy,including building legislation procedure of getting and using gene resource and ethic frame of sharing gene resource.",
        "keywords": [
            "biopiracy",
            "intellectual property rights",
            "gene resource protecting"
        ],
        "authors": [
            {
                "name": "WU Li-zeng",
                "org": "Policy and Regime Department of Fujian Science and Technology Office,Fuzhou  China"
            },
            {
                "name": "HUANG Xiu-juan",
                "org": "Economics and Management College of Fujian Agricultural and Forestry University,Fuzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Economics and Management College of Fujian Agricultural and Forestry University,Fuzhou ,China"
            }
        ],
        "venue": "Modern Agricultural Sciences",
        "year": 2008
    },
    "BFUHYi2l": {
        "id": "BFUHYi2l",
        "title": "Empirical Study on Changes of Energy Consumption and Supply& Demand Gap in Fujian Province",
        "abstract": "Acoording to the socio-economic development and industrial restructuring in Fujian,this paper analyzes the situation of energy consumption and industrial consumption.Combining with supply&demand relaitonship and transferred amount of energy in Fujian,and based on the grey model,it empirically studies supply&demand gap of energy in Fujian in order to evaluate the security of energy supply in Fujian.The results show that the contradiction between energy supply and demand in Fujian is obvious. For Fujian province,changing traditional path dependence of energy,and developing circular economy and green energy,are the inevitable choices.",
        "keywords": [
            "supply&demand gap",
            "energy consumption",
            "Fujian province"
        ],
        "authors": [
            {
                "name": "Liu Feixiang",
                "org": "College of Crop Science,Fujian Agriculture and Forestry University,Fuzhou ,China"
            },
            {
                "name": "Liu Weiping",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry university,Fuzhou ,China"
            },
            {
                "name": "Liu Shuangming",
                "org": "College of Jiangxia,Fuzhou ,China"
            }
        ],
        "venue": "Technology Economics",
        "year": 2010
    },
    "IrvRooKc": {
        "id": "IrvRooKc",
        "title": "Forest Used to Produce Carbon Emission Right Is the Choice of Forest Product Industry to Counteract the Carbon Emissions",
        "abstract": "An opinion is proposed in this paper that forest management behavior as its object is to increase the car bon sequestration ability should obtain the carbon emission right.Forest used to counteract the emission of carbon has two aspects:concerted action and forestry resources assets management.Concerted action of forest product in dustry can lead their to be a forest business entity and can to reduce the production and transaction cost of carbon emission right.To accounting the increase of carbon sequestration which through the \"carbon credit\" account is the target of forestry resources assets management.The mechanism of forest used to counteract the carbon emission has four advantages as it beneficial to forest product industry financing,stabilizing prices of raw materials and so on.",
        "keywords": [
            "forest product industry",
            "carbon emission right",
            "forest counteract carbon emission mechanism"
        ],
        "authors": [
            {
                "name": "Feng Liangming",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou "
            },
            {
                "name": "Liu Weiping",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou "
            }
        ],
        "venue": "Forestry Economics",
        "year": 2012
    },
    "bfDfXaDx": {
        "id": "bfDfXaDx",
        "title": "Analysis of Forest Optimal Rotation Which Base on the Value of Carbon Sequestration",
        "abstract": "From the perspective of forest land operators'different forest management objectives,theoretical analyzed optimal rotation which forest land operators seek to maximize economic benefits,maximize the environmental benefits,maximize economic and environmental benefits,and then under the Kyoto mechanisms,analyzed the forest optimal rotation which in the consideration of the value of carbon sequestration,studied the optimal rotation that woodland have achieved the value of carbon sequestration,discovered that forest operation activities,such as rotation,land use,afforestation,etc,which have considered the value of carbon sequestration would be changed in the pursuit of maximizing forest land expectation value,while achieved the value of carbon sequestration need to improve the appropriate policies and develop the forest carbon sequestration market.",
        "keywords": [
            "optimal rotation",
            "the value of carbon sequestration",
            "forest"
        ],
        "authors": [
            {
                "name": "JIAN Gai-yuan",
                "org": "Economics and Management College of FAFU,Fuzhou  China"
            },
            {
                "name": "FENG Liang-ming",
                "org": "Economics and Management College of FAFU,Fuzhou  China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Economics and Management College of FAFU,Fuzhou  China"
            }
        ],
        "venue": "Issues of Forestry Economics",
        "year": 2011
    },
    "eIinvAiq": {
        "id": "eIinvAiq",
        "title": "An Empirical Study of the Development of Export-oriented Agriculture Based on Competitiveness in Fujian",
        "abstract": "Firstly, the author explains advantages and effectiveness of agricultural opening in Fujian, based on the understanding of the characteristics and changes of export-oriented agricultural trade in Fujian, through building measure model of provincial agricultural competitiveness of export-oriented degree and evaluate provincial agricultural competitiveness of export-oriented degree in Fujian compositely, and analyses in-depth its ranking in the country and developments and causes. Finally, from the angle of enhancing the agricultural competitiveness of export-oriented degree in Fujian, the author applies new thinking in order to advance the international, modern agriculture strategy.",
        "keywords": [
            "Evaluation",
            "Indicators measure",
            "Competitiveness of export-oriented degree",
            "Export-oriented agriculture",
            "Fujian"
        ],
        "authors": [
            {
                "name": "Liu Feixiang",
                "org": "1 College of crop science , FAFU, Fuzhou Fujian . "
            },
            {
                "name": "Liu Weiping",
                "org": "2 College of economics and management , FAFU , Fuzhou Fujian "
            },
            {
                "name": "Ruan Xueqing",
                "org": "1 College of crop science , FAFU, Fuzhou Fujian . "
            },
            {
                "name": "Zhan Jiwen",
                "org": "1 College of crop science , FAFU, Fuzhou Fujian . "
            }
        ],
        "venue": "Chinese Agricultural Science Bulletin",
        "year": 2010
    },
    "sVp2S18a": {
        "id": "sVp2S18a",
        "title": "Studies on the effect of FDI on carbon emissions in Fujian",
        "abstract": "This paper investigates the validity of the pollution haven hypothesis in the context of foreign direct investment( FDI) in Fujian Provence by determining the correlations between carbon emission and foreign direct investment between 2001 and 2011. Statistical results from co-integration test,and Granger Causality Test show that CO2 emission has a statistical relationship with FDI and FDI is the reason for the increasing CO2 emission in Fujian between 2001 and 2011.",
        "keywords": [
            "FDI",
            "Granger Causality Test",
            "CO2 emission"
        ],
        "authors": [
            {
                "name": "HE Jun-lin",
                "org": ""
            },
            {
                "name": "WANG Wen-lan",
                "org": ""
            },
            {
                "name": "LIU Wei-ping",
                "org": ""
            },
            {
                "name": "ZHUO Jiang-ying",
                "org": ""
            }
        ],
        "venue": "Journal of Fujian Agriculture and Forestry University(Philosophy and Social Sciences)",
        "year": 2013
    },
    "GqwlXhUC": {
        "id": "GqwlXhUC",
        "title": "The Analysis of Forest Carbon Production's Elements Flow Mechanism",
        "abstract": "Analyzed the major components including labor,capital and land,from the forest carbon production function,through the three aspects such as elements price,alternative between the elements and elements environment to study forest carbon production's elements flow mechanism,put forward through five aspects such as the implementation of national energy conservation and emission reduction policy,improving forest operators' carbon production cognitive,perfecting forest carbon production elements of land management,safeguarding forest carbon production funds and perfecting carbon emissions trading market to ensure elements flow reasonably and effectively.",
        "keywords": [
            "elements flow",
            "carbon sequestration",
            "forest carbon production",
            "CO2 emission reduction and energy saving"
        ],
        "authors": [
            {
                "name": "JIAN Gai-yuan",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            },
            {
                "name": "FENG Liang-ming",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            }
        ],
        "venue": "Issues of Forestry Economics",
        "year": 2013
    },
    "qbE8XrG1": {
        "id": "qbE8XrG1",
        "title": "The Analysis and Total Research on Fujian Agriculture Development",
        "abstract": "Based on the definition of realistic and strategic meaning of Fujian agriculture development,and through analysis and calculation the statistic data in Fujian from 1995,we make analysis and total research on the situation of the development of Fujian agriculture, finally, this article put forword the basic access selection which is mainly pulled by the power of marketing economy ;promotes the production ability of agriculture;and promotes special production in local area from all-directions.",
        "keywords": [
            "development",
            "agriculture",
            "Fujian"
        ],
        "authors": [
            {
                "name": "LIU Fei-xiang",
                "org": "College of Economics and Management, Fujian Agriculture and Forestry University, Fuzhou , China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "College of Economics and Management, Fujian Agriculture and Forestry University, Fuzhou , China"
            },
            {
                "name": "XIA Wen-ding",
                "org": "College of Economics and Management, Fujian Agriculture and Forestry University, Fuzhou , China"
            }
        ],
        "venue": "Science Technology and Industry",
        "year": 2007
    },
    "aUVKHlpJ": {
        "id": "aUVKHlpJ",
        "title": "Study on Operating Behavior Characteristics of Camellia Oleifera Abel Farming Households\u2014\u2014A Case Study of Fujian Camellia oleifera Abel Planters",
        "abstract": "Taking Camellia oleifera Abel growers as the survey respondents,the paper analyzes the farming households\ue6afoperating behavior characteristics of Camellia oleifera Abel in Fujian,which is one of the main provinces of growing Camellia oleifera Abel,for the purposes of showing the operating characteristics of farming households from descriptive statistical analysis,and as a whole to grasp micro-foundation for the industrial development of Camellia oleifera Abel.The results show that:in the existing Camellia oleifera Abel forest,the largest proportion is the old Camellia oleifera Abel forest,the scale of family-run is small,the land used to plant Camellia oleifera Abel is mainly barren hills and wasteland,the status of resources allocation for Camellia oleifera Abel is low in the farming households,and the management of most small Camellia oleifera Abel plots is inefficient.In the past 5 years,the new afforestation Camellia oleifera Abel forest showed a trend of expanding scale,and the adoption of nuture technology of these farmers increased.",
        "keywords": [
            "farming households",
            "Camellia oleifera Abel",
            "operating behavior"
        ],
        "authors": [
            {
                "name": "HONG Yan-zhen",
                "org": "a.Economics and Management College,"
            },
            {
                "name": "YU Yun",
                "org": "b.Art and Gardens College of Fujian Agriculture and Forestry University,Fuzhou  China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "a.Economics and Management College,"
            }
        ],
        "venue": "Issues of Forestry Economics",
        "year": 2011
    },
    "AbYOCZNF": {
        "id": "AbYOCZNF",
        "title": "Economic Analysis about Property Right Deployment and Benefit Allotment of Genetic Resources",
        "abstract": "Using property right theory and principal-agent theory in economics,this paper studies the issue of property right deployment and benefit allotment of genetic resources.First,it compares the economic efficiency of different primary deployments models of various property rights of genetic resources from their static and dynamic states and concludes that different property right deployment models of genetic resources are different in their economic efficiency.Then,by the principal-agent theory,this paper analyses the problem of the benefit allotment of plant breeding rights and concludes that if the developed countries allot part of benefits derived from the newly bred plants with the genetic resources to the developing countries,a \"two-win\" result can be achieved.",
        "keywords": [
            "genetic resource",
            "property right theory",
            "property right deployment",
            "principal-agent theory"
        ],
        "authors": [
            {
                "name": "HUANG Xiu-juan",
                "org": "Economics and Management College of Fujian Agricultural and Forestry University,Fuzhou,Fujian  China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Economics and Management College of Fujian Agricultural and Forestry University,Fuzhou,Fujian  China"
            },
            {
                "name": "WU Li-zeng",
                "org": "Policy and Regime Department of Fujian Science and Technology Office,Fuzhou,Fujian ,China"
            },
            {
                "name": "HUANG Yuan-cai",
                "org": "Economics and Management College of Fujian Agricultural and Forestry University,Fuzhou,Fujian  China"
            },
            {
                "name": "LU Su-lan",
                "org": "Economics and Management College of Fujian Agricultural and Forestry University,Fuzhou,Fujian  China"
            }
        ],
        "venue": "Journal of Southwest Agricultural University(Social Sciences Edition)",
        "year": 2009
    },
    "9dahq1k3": {
        "id": "9dahq1k3",
        "title": "Research on the revitalization measures of the traditional Chinese medicine industry in Taiwan",
        "abstract": "In Taiwan,as the purpose of \"Scientific Traditional Chinese Medicine\" of traditional Chinese medicine industry,which has made significant achievements,there accumulated many of the experiences in management practices,innovative approaches,industrial transformation and upgrading for revitalization of traditional Chinese medicine industry.In-depth analysis of the experiences and initiatives for revitalization of the traditional Chinese medicine industry in Taiwan is helpful to make recommendations accordingly on how to revitalize the traditional Chinese medicine industry in Fujian and to jointly promote the revitalization of the traditional Chinese medicine industry in Fujian and Taiwan.",
        "keywords": [
            "Taiwan",
            "the traditional Chinese medicine industry",
            "cooperation between Fujian and Taiwan"
        ],
        "authors": [
            {
                "name": "HOU Chang-hong",
                "org": "College of Economics,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China"
            },
            {
                "name": "YANG Jiang-fan",
                "org": "College of Economics,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China;Wuyi University,Wuyishan,Fujian ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "College of Economics,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China"
            },
            {
                "name": "ZHENG Gang",
                "org": "College of Bee Science,Fujian Agriculture and Forestry University, Fuzhou,Fujian ,China"
            },
            {
                "name": "WU Yu-lin",
                "org": "College of Food Science,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China"
            },
            {
                "name": "LIN Mei-rong",
                "org": "College of Food Science,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China"
            },
            {
                "name": "LIN Guang-mei",
                "org": "College of Food Science,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China"
            }
        ],
        "venue": "Journal of Fujian Agriculture and Forestry University(Philosophy and Social Sciences)",
        "year": 2013
    },
    "d7W8nQcc": {
        "id": "d7W8nQcc",
        "title": "Positive Analysis on Residents' Willingness to Compensate for the Ecological Forests\u2014\u2014A Study Based on an Investigation of Guangzhou City",
        "abstract": "The paper took the ecological forests of Guangzhou City as a typical example,through questionnaire and investigation,and CVM and multivariate statistics method,analyzed residents' willingness to compensate for the ecological forest and the influencing factors.The results are: a big gap existed in terms of the residents willingness to compensate for the ecological forest of Guangzhou City,the E(WTP)=27.79 yuan/(mouth\u00b7family),the median is 4.13,the average value of sample is 19.82.The residents' willingness to compensate for the ecological forest are conditioned by factors including age,sex,educational status,occupation,household income and so on.Among them,household register,occupation,environment awareness and their satisfaction about the environmental reality are the most important influencing factors.",
        "keywords": [
            "willingness to pay",
            "influencing factors",
            "ecological benefit",
            "ecological forest"
        ],
        "authors": [
            {
                "name": "ZHANG Mei",
                "org": "College of Economics and Management,Southwest Forestry University,Kunming ,China;College of Economics and Management,FAFU,Fuzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "College of Economics and Management,FAFU,Fuzhou ,China"
            }
        ],
        "venue": "Journal of Jiangxi Agricultural University(Social Sciences Edition)",
        "year": 2011
    },
    "9HM7edun": {
        "id": "9HM7edun",
        "title": "SWOT Analysis on Developing the New Low-carbon Industry in Fujian",
        "abstract": "By using the method of SWOT analysis,this paper explores the development of the emerging low-carbon industry in Fujian.Although the emerging low-carbon industry in Fujian has the advantages such as the strong car- bon sequestration capacity,policies support,but it still faces the difficulties such as low-efficiency energy conver- sion,difficult research and development of low-carbon technology and so on.Base on the analysis,this paper put forward the countermeasures to promote the development of the emerging low-carbon industry in Fujian.",
        "keywords": [
            "SWOT analysis",
            "industrial park",
            "low-carbon industries",
            "low-carbon economy"
        ],
        "authors": [
            {
                "name": "CHEN Yan-huang",
                "org": ""
            },
            {
                "name": "LIU Wei-ping",
                "org": ""
            },
            {
                "name": "CHEN Lin",
                "org": ""
            },
            {
                "name": "LI Huan-ting",
                "org": ""
            },
            {
                "name": "SHI Qiao-ling",
                "org": ""
            },
            {
                "name": "ZHUANG Pei-fen",
                "org": ""
            }
        ],
        "venue": "Taiwan Agricultural Research",
        "year": 2013
    },
    "3rygLiA3": {
        "id": "3rygLiA3",
        "title": "An Study on Compensation Standard of Ecological Forest:An Info Marginal Economics Frame",
        "abstract": "The article introduced the study achievements of the standard of ecological forest's compensation,and then structure an info marginal economics frame.through the former on division of labors and the analysis from forestry farmer's decision-making model,then analyze the balanced pattern.At last give us some conclusion:The standard of compensation is direct proportional with population;is inversely proportional to efficiency of transfer payment and ecological forest's acreage.At the same time,according to the comparatives static study,we point out that the standard of compensation is between the forestry pattern of provide for oneself completely and the pattern of specialization completely to produce ecological forest.The frame of analysis can solve a series of problems of ecological forest compensation;give some advices for government to law down the standard of compensation.",
        "keywords": [
            "theory on division of labors",
            "compensation standard",
            "ecological forest compensation",
            "info marginal economics"
        ],
        "authors": [
            {
                "name": "ZHANG Mei",
                "org": "Department of Economics and Management of Fujian Agriculture and Forestry University,Fuzhou  china;Department of Economics and Management of Southwest Forestry College,Kunming  China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Economics and Management of Fujian Agriculture and Forestry University,Fuzhou  china"
            }
        ],
        "venue": "Issues of Forestry Economics",
        "year": 2010
    },
    "RhovidlL": {
        "id": "RhovidlL",
        "title": "Farmers' Medical Care Seeking Behaviors in the New Rural Cooperative Medical Care System in Fuzhou:An Empirical Study",
        "abstract": "Based on Grossman's theory,this study makes an empirical study on farmers' medical care seeking behavior,choice of hospital,burden of medical expenses and the influencing factors in several counties of Fuzhou city by applying the quantitative methods in Probit Model and Multi-logit Model.The following conclusions have been made:(1) such socioeconomic factors as level of education,health,burden coefficient,income level and family size have significant influence on the farmers' medical selection;while factors such as gender,age,and whether the farmer is a CPC member or a village official do not have remarkable effect;(2) the distance to medical institutions has influenced the farmers' selection of medical institutions;(3) the New Rural Cooperative Medical Care System has a positive impact on reducing the farmers' burdens.It is suggested that the government raise the medical reimbursement rate,set a lower standard for medical reimbursement,simplify the systems related to farmers,utilize the cooperative medical fund rationally and formulate proper plans for outpatient and inpatient reimbursement.",
        "keywords": [
            "Fuzhou",
            "new rural cooperative medical care",
            "medical care units",
            "medical care seeking behavior"
        ],
        "authors": [
            {
                "name": "GUAN Rui-qi",
                "org": "Institute of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Institute of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou ,China"
            },
            {
                "name": "LU Su-lan",
                "org": "Institute of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou ,China"
            }
        ],
        "venue": "Journal of Fujian Medical University(Social Science Edition)",
        "year": 2011
    },
    "7hXqxGJp": {
        "id": "7hXqxGJp",
        "title": "Study on building farmers credit evaluation system",
        "abstract": "Farmers credit evaluation indices system that is constructed by 28 second indices,such as farmers\u2032 age,health status,level of education,special techniques and skills and so on,is built from five aspects of household characteristics,solvency,operating conditions,reputation conditions and other indicators on the basis of the review of previous research combined with the characteristics of farmers.Accordingly analytic hierarchy process is used to construct the index judgment matrix and calculate the index weight in order to lay the theoretical foundation for scientific evaluation of farmer credit.",
        "keywords": [
            "weight",
            "farmer",
            "indices system",
            "credit"
        ],
        "authors": [
            {
                "name": "LAI Yong-wen",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China;Fuzhou Center Branch,The People\u2032s Bank of China,Fuzhou,Fujian ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China"
            }
        ],
        "venue": "Journal of Fujian Agriculture and Forestry University(Philosophy and Social Sciences)",
        "year": 2012
    },
    "CENM7hSc": {
        "id": "CENM7hSc",
        "title": "Peasant's Cognition on the Value of Bee Pollination\u2014\u2014Based on the Empirical Study of Fujian",
        "abstract": "Chinese bee pollination service value of 3.0422 \u00d7 1011 Yuan,and peasant household was the main service object of bee pollination.In order to comprehensively and thoroughly understand peasant\u2019s cognition on the value of bees and bee pollination,the authors had signed relevant questionnaires for investigating 194 peasant households of 6 cities in Fujian Province.According to the survey data,the paper analyzed in detail the cognition status of peasant about bees,the value of bee pollination,renting bees and bee protection.The results showed that 78.87 percent of households had recognized the yield-increase effect caused by bee pollination,62.37 percent of peasants had recognized bee pollination as an absolutely essential agricultural input,along with other conventional input such as fertilizers and pesticides,and thought government departments should carried out the bees resource protection projects and would to pay a fee accounted for 68.04%.However,only 16.49% of peasants intended to rent honeybees to pollinated crops and to pay some costs in agricultural production.The government should play a significant and leading role in development of bee pollination services,this paper provided some suggestions about supporting the beekeeping cooperative organizations,centralization management of renting honeybees,and so on.",
        "keywords": [
            "bees",
            "bee pollination",
            "peasant's cognition",
            "willing to pay"
        ],
        "authors": [
            {
                "name": "Li Haiyan",
                "org": "Economic and Management College of Fujian Agriculture and Forestry University,Fuzhou ;Bee Research Institute,Chinese Academy of Agricultural Sciences,Beijing "
            },
            {
                "name": "Liu Pengfei",
                "org": "Bee Research Institute,Chinese Academy of Agricultural Sciences,Beijing "
            },
            {
                "name": "Liu Weiping",
                "org": "Economic and Management College of Fujian Agriculture and Forestry University,Fuzhou "
            },
            {
                "name": "Lin Suwen",
                "org": "College of Crop Science,Fujian Agriculture and Forestry University,Fuzhou "
            }
        ],
        "venue": "Chinese Agricultural Science Bulletin",
        "year": 2012
    },
    "IwsaUyVC": {
        "id": "IwsaUyVC",
        "title": "Study on the Role of Wild Vegetable Resource for Food Safety at Nutrition Transition Stage",
        "abstract": "The article describes the prominent food safety issues at nutrition transition stage,elaborates the evolution of food safety content in food consumption view to upgrade perspective,and analyzes the importance of wild vegetable resources for food safety at nutrition transition stage.In addition,it proposes the measures to accelerating the development of wild resources as well.",
        "keywords": [
            "development",
            "food safety",
            "wild vegetable resource",
            "nutrition transition stage"
        ],
        "authors": [
            {
                "name": "CHEN Mei-ying",
                "org": "College of Economics and Management,Fujian Agricultural and Forestry University,Fuzhou ,China;College of Food Science,Fujian Agricultural and Forestry University,Fuzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "College of Economics and Management,Fujian Agricultural and Forestry University,Fuzhou ,China"
            },
            {
                "name": "DAI Yong-wu",
                "org": "College of Economics and Management,Fujian Agricultural and Forestry University,Fuzhou ,China"
            },
            {
                "name": "HONG Yan-zhen",
                "org": "College of Economics and Management,Fujian Agricultural and Forestry University,Fuzhou ,China"
            }
        ],
        "venue": "Journal of Shanxi Agricultural Sciences",
        "year": 2011
    },
    "IVfR8MeE": {
        "id": "IVfR8MeE",
        "title": "Analysis on Constraint Factors and Strategies of Woody Grain Industry Development in China",
        "abstract": "The development of woody food is the strategy way to guarantee Chinese food security.On the basis of development status of woody food industry in China,the paper analyzes deeply the potential and constraint factors for the development of woody food industry in China.The result shows that development potential of Chinese woody food industrial is great,but also faces such constraints as the backward cultivation techniques,the small processing capacity,a low comprehensive utilization rate,the weak international market development and the small intensity of policy support,ect.Based on the conclusion,some development strategies of woody grain industry are put forward,including formulating scientifically development planning,promotion of the industrialization of standard construction,improvement the product deep processing and comprehensive utilization of capacity,the development of international markets in Europe and America and enhancement intensify of policy support.",
        "keywords": [
            "strategies",
            "woody grain industry",
            "constraint factors"
        ],
        "authors": [
            {
                "name": "Dai Yongwu",
                "org": " Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou "
            },
            {
                "name": "Liu Weiping",
                "org": " Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou "
            },
            {
                "name": "Hong Yanzhen",
                "org": " Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou "
            },
            {
                "name": "Chen Meiying",
                "org": " Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou "
            },
            {
                "name": "Dong Jiayun",
                "org": " School of Agricultural Economics and Rural Development,Renmin University of China,Beijing "
            }
        ],
        "venue": "Forestry Economics",
        "year": 2012
    },
    "h0I8U5u5": {
        "id": "h0I8U5u5",
        "title": "Study on Current Status and Promotion Strategy of International Competitiveness of Chinese Chestnut Industry",
        "abstract": "The paper evaluates quantitatively and contrasts internationally the international competitiveness of Chinese chestnut industry,and then analyzed deeply the factors of the international competitiveness of Chinese chestnut industry on the basis of Porter's diamond model,based on the data about chestnut trade from UNcomtrade online database in the period of 1992-2009.The result shows that Chinese chestnut industry has a strong international competitiveness from low labor costs and huge domestic market,but the traditional low-cost competitive advantage is gradually lost by the impact of rising labor costs and low scientific and technological innovation capability.Based on the conclusion,this article put forward some strategies to promote the international competitiveness of Chinese chestnut industry,including farmers training efforts to strengthen and enhancing the ability of technological innovation,the development of chestnut processing industry and the implementation of brand strategy.",
        "keywords": [
            "chestnut",
            "import and export trade",
            "industry international competitiveness"
        ],
        "authors": [
            {
                "name": "DAI Yong-wu",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China"
            }
        ],
        "venue": "Research of Agricultural Modernization",
        "year": 2012
    },
    "OMWF4wuo": {
        "id": "OMWF4wuo",
        "title": "An Analysis of the Factors of Farmer Choosing Tea Marketing Channel in the Tea Industry Developed Area\u2014\u2014An empirical study based on household's data In Anxi county of Fujian Province",
        "abstract": "Anxi county,Fujian province farmers survey data,the use of two Logistic model analysis the affecting factors what tea farmers choose sales channels.Studies have shown that the head of household age has no significant impact to the tea farmer choosing sale channels;the head of household whether village cadres of farmers to open their own tea shop has a significant influence;Farmers household whether to participate in the tea farmers cooperative organizations affects obviously them to choose the tea sales channel of cooperative organization;Tea-income proportion of total household income from 0 to 25%,26%\uff5e50% to open their own tea shop has a significant influence,51%\uff5e75% to choose the tea sales channel of dealers has a significant influence;The household to the nearest tea market distance \u22643 km,has significant impact to the tea farmer choosing two sale channels of dealers and tea markets.Based on these results,this paper puts forward the related policy proposal.",
        "keywords": [
            "tea sales channels",
            "influencing factors",
            "tea farmers",
            "2 Logistic models"
        ],
        "authors": [
            {
                "name": "SU Bao-cai",
                "org": "Economics And Management College of Fujian Agriculture And Forestry University,Fuzhou  China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Economics And Management College of Fujian Agriculture And Forestry University,Fuzhou  China"
            }
        ],
        "venue": "Issues of Forestry Economics",
        "year": 2008
    },
    "ywIMK3zu": {
        "id": "ywIMK3zu",
        "title": "Economic Benefits Evaluation of Farmers' Investment of High-yield Camellia Oleifera Stands\u2014\u2014A Case Study of Youxi County Fujian Province",
        "abstract": "Based on the theory of rational smallholders,the paper uses of risk-adjusted discount rate method toevaluate the investment economic benefits of high-yield camellia oleifera stands according to the research data ofYouxi county Fujian province,results show that:when the risk-adjusted discount rate is 12%,the investmentproject of high-yield camellia oleifera stands is economically viable;the internal rate of return of investment projects of high-yield camellia oleifera stands whose operating life is between 20 years to 50 years is 17.12%\uff5e17.67%.Further sensitivity analysis shows that:the net present value on the camellia oleifera stands is sensitiveto the selling price of crude oil,yield of camellia oleifera stands and the production cost of oil.Finally,the paperbring forwards relevant policy recommendations.",
        "keywords": [
            "sensitivity analysis",
            "NPV",
            "high-yield camellia oleifera stands"
        ],
        "authors": [
            {
                "name": "Dai Yongwu",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou "
            },
            {
                "name": "Liu Weiping",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou "
            },
            {
                "name": "Hong Yanzhen",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou "
            }
        ],
        "venue": "Forestry Economics",
        "year": 2010
    },
    "BmOGFgzn": {
        "id": "BmOGFgzn",
        "title": "Study on Kinds of People's Potential Consummations of Forest Healthcare-Based Tourism\u2014\u2014Take Fujian province for example",
        "abstract": "With the basis of health status and health care market characteristics and guided by the traditional health culture,and health knowledge,this study put forward that the forest health tourism is the new style for tourism which object is cultivate and maintenance the physical and mental,and in the context of the forest environment,with the foundation of traditional health culture,the tourism create\"forest-Natural health Museum\",the main theme of the tourism is to the various forms of health care activities as,a variety of tourism resources and the infrastructure conditions in a variety of health care tourism.Based on the theory of marketing,a product entering the market in the early stages of the adoption of market research survey of potential consumers is essential.In view of this,and the author on the basis of previous studies,the use of tourism marketing,economics,statistics,the Chinese health science,ecology and other related scientific theories and knowledge research,and research methods used,including a major field survey,literature analysis,quantitative analysis,and conducted a survey analysis by taking Fuzhou City\u3001Xiamen City,Quanzhou City of Fujian for example,in conjunction with other types of consumer behavior and its impact on tourism factors on forest health tourism precedent and the special conditions and the objective reality,the corresponding assumptions,and selected personal level analysis of the factors influencing the health of forest tourism consumer attitudes and intentions.",
        "keywords": [
            "potential consume",
            "Fujian province",
            "forest health care-based tourism"
        ],
        "authors": [
            {
                "name": "LU Su-lan",
                "org": "Agriculture and Forestry Economy Management Fujian Agriculture and Forestry University,Fuzhou  China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Agriculture and Forestry Economy Management Fujian Agriculture and Forestry University,Fuzhou  China"
            }
        ],
        "venue": "Issues of Forestry Economics",
        "year": 2009
    },
    "uFfPi4yI": {
        "id": "uFfPi4yI",
        "title": "An empirical analysis on tobacco farmers' planting scale efficiency in Fujian province",
        "abstract": "Cultivation data of tobacco farmers was analyzed with Data Envelopment Analysis method to study the relationship between tobacco-planting scale and efficiency and to determine optimal planting scale,.It was concluded that the optimal scale of tobacco farmers' planting area is 2 to 2.33 hm2 in the current production technology level in Fujian Province.",
        "keywords": [
            "tobacco farmer",
            "scale efficiency",
            "modern tobacco agriculture",
            "Data Envelopment Analysis"
        ],
        "authors": [
            {
                "name": "ZHANG Hong-yong",
                "org": " College of Economy and Management,Fujian Agriculture and Forestry University, Fuzhou ,China; Fujian Provincial Tobacco Corporation,Fuzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": " College of Economy and Management,Fujian Agriculture and Forestry University, Fuzhou ,China"
            }
        ],
        "venue": "Acta Tabacaria Sinica",
        "year": 2012
    },
    "JF3uXWsA": {
        "id": "JF3uXWsA",
        "title": "Research on the Coordinative Evaluation between Surrounding Environment and Tourist Environment of Forest Park\u2014\u2014A case study of Fuzhou National Forest Park",
        "abstract": "After definiting surrounding environment and tourist environment of forest park,an evaluating system based on tourist's perspective has been constructed,including an evaluating model,appraising indexes and standard of coordination degree.Then Fuzhou National Forest Park has been taken as a case to evaluate coordinative situation between surounding environment and tourist environment.The case study shows,the coordinative situation between surounding environment and tourist environment of Fuzhou National Forest Park is coordination at Intermediate level of environmental quality.At last,to get coordination at high level of environmental quality between surrounding environment and tourist environment of Fuzhou National Forest Park,a measurement about carrying out the development model that integrate surrounding area with forest park has been proposed.",
        "keywords": [
            "forest park",
            "surrounding environment",
            "tourist environment",
            "coordinative evaluation"
        ],
        "authors": [
            {
                "name": "CHEN Xiao-qin",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            },
            {
                "name": "CHEN Gui-song",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            }
        ],
        "venue": "Issues of Forestry Economics",
        "year": 2012
    },
    "JiVXqOLl": {
        "id": "JiVXqOLl",
        "title": "The Problem, Objective and Access of Modern Agriculture Construction in Fujian",
        "abstract": "Under the background of new rural construction, according to the requestion and arrangement of one hundred special social science lectures and one hundred villages investigation activities that Fijian social science association associated with Fujian publicity department developed, based on the extensive data collected from 69 administrative village and the analysis the data of the investigation of one hundred village and the statistics of many years in Fujian, the group of modern agriculture subject of in college of College of economics and management analyze profoundly the agricultural situations of nine districts divided three economic level in Fujian (prosperous districts along sea, undeveloped districts along sea, undeveloped mountain areas), according to the total object and stage object of modern agricultural construction, finally, put forward four main countermeasures that step up the development of Fujian agriculture.",
        "keywords": [
            "New rurual construction",
            "Modern agriculture",
            "Fujian"
        ],
        "authors": [
            {
                "name": "Liu Feixiang",
                "org": "College of economics and management,Fujian Agriculture and Forestry University, Fuzhou, Fujian "
            },
            {
                "name": "Liu Weiping",
                "org": "College of economics and management,Fujian Agriculture and Forestry University, Fuzhou, Fujian "
            },
            {
                "name": "Qian Dingwei",
                "org": "College of economics and management,Fujian Agriculture and Forestry University, Fuzhou, Fujian "
            }
        ],
        "venue": "Chinese Agricultural Science Bulletin",
        "year": 2007
    },
    "iqBK2jVm": {
        "id": "iqBK2jVm",
        "title": "A Discussion on the Compensation Standard for Ecological Forest",
        "abstract": "The paper introduced systematically the study of the compensation standard for ecological forest, including the theoretical basis,the empirical study of compensation. At the same time,it puts forward the problems in the compensation standard in China. Finally,some advices were proposed for establishing the reasonable compensation standard for ecological forests.",
        "keywords": [
            "compensation mechanism",
            "compensation standard",
            "ecological forest"
        ],
        "authors": [
            {
                "name": "Zhang Mei",
                "org": " Department of Economics and Management of Fujian Agriculture and Forestry University,Fuzhou ,China; Faculty of Economics and Management of Southwest Forestry College,Kunming ,China"
            },
            {
                "name": "Liu Weiping",
                "org": " Department of Economics and Management of Fujian Agriculture and Forestry University,Fuzhou ,China"
            }
        ],
        "venue": "World Forestry Research",
        "year": 2010
    },
    "iA4NcWg8": {
        "id": "iA4NcWg8",
        "title": "Empirical Analysis of Consumers\u2019Cognition of Oil-tea Camellia Seed Oil Value\u2014\u2014Based on Consumers\u2019Investigation of Fuzhou",
        "abstract": "Consumer lacking of cognition of oil-tea camellia seed oil value causes asymmetric information and mar ket failure,which makes the potential market demand can't become actual market demand.Through counting wheth er consumer heard of oil-tea camellia seed oil and which value does they kown,we find that most of consumers heard ofit,however,just a small part of consumers have a high cognition ofits value.We also find that sex,education al background,income and concern of health are the main reason ofimpacting on consumers' cognition of oil-tea camellia seed oil value.Consumers' cognition of oil-tea camellia seed oil value no more depend on the planting and processing places and buying of daily food.From the empirical result,we can predict that increasing people will have a high cognition of oil-tea camellia seed oil value.In order to stimulate consumers' cognition of oil-tea camellia seed oil value,we need continue to eliminate the residents' awareness of gender preference, and promote the equita ble distribution of educational resources, and reduce the difficulty for access to higher education, and promote the ra tional allocation of ofincome ,as well as improving health concerns of people.",
        "keywords": [
            "influencing factors",
            "camellia seed oil value",
            "consumer",
            "cognition",
            "Camellia"
        ],
        "authors": [
            {
                "name": "Dong Jiayun",
                "org": " Renmin University of China, Beijing "
            },
            {
                "name": "Liu Weiping",
                "org": " Fujian Agriculture and Forestry University, Fuzhou "
            },
            {
                "name": "Liu Jinlong",
                "org": " Renmin University of China, Beijing "
            },
            {
                "name": "Fang Jiangxia",
                "org": " Fujian Agriculture and Forestry University, Fuzhou "
            }
        ],
        "venue": "Forestry Economics",
        "year": 2012
    },
    "yFrnKJYv": {
        "id": "yFrnKJYv",
        "title": "Analysis of Forest Carbon Production's Price Compensation",
        "abstract": "By analyzing the economic attribute of the forest carbon production shows that the forest carbon production has positive external effects,its product has the public goods attribute,appropriate price compensation to motivate production behavior,by investigating the opportunity cost of woodland and forest to set price compensation standard,put forward to deepening the reform of forest right system,clear the forest carbon emissions,improve the forest ecological compensation legal policy,replenish the forest carbon compensation policy,diversified production channels of funds,improve investment and financing system and so on three aspects of forest carbon production policy protection forest carbon production price compensation.",
        "keywords": [
            "ecological compensation",
            "forest carbon production",
            "cost of chance",
            "price compensation"
        ],
        "authors": [
            {
                "name": "JIAN Gai-yuan",
                "org": "Economics and Management College of FAFU,Fuzhou  China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Economics and Management College of FAFU,Fuzhou  China"
            },
            {
                "name": "FENG Liang-ming",
                "org": "Economics and Management College of FAFU,Fuzhou  China"
            }
        ],
        "venue": "Issues of Forestry Economics",
        "year": 2013
    },
    "kdVKUcUU": {
        "id": "kdVKUcUU",
        "title": "STRATEGY FOR DEVELOPING GREEN RURAL ENERGY IN FUJIAN PROVINCE",
        "abstract": "This paper carries out thorough analysis on the strategic significance,development method,development potential for developing green energy in Fujian province,setting off from the internal and external economic development and energy utilization situation,and also from the conflict between the urgent need for energy development to realize complete well-off in rural areas and the reality.At last,this paper raises counter measures for green energy development in Fujian Province.",
        "keywords": [
            "construction of new rural areas",
            "Fujian",
            "green energy",
            "development strategy"
        ],
        "authors": [
            {
                "name": "Liu Feixiang",
                "org": "Economic Management College,Fujian Agriculture and Forest University, Fuzhou "
            },
            {
                "name": "Liu Weiping",
                "org": "Economic Management College,Fujian Agriculture and Forest University, Fuzhou "
            }
        ],
        "venue": "Chinese Journal of Agricultural Resources and Regional Planning",
        "year": 2007
    },
    "gGNlDDyG": {
        "id": "gGNlDDyG",
        "title": "Evaluation Model of Forest Park Tourism Products and Its Application\u2014\u2014In View Point of Suitability of Tourism Product Development",
        "abstract": "The forest tourism product evaluation theory,which is an essential part in the tourism product development theory,provides crucial knowledge to reduce the blindness and increase the success probability of developing forest tourism products.The paper deeply analyzed the problem and built a synthetic evaluating model.First,the paper analyzed the factors of affecting forest park tourism products by means of economic and tourism theory,built indexes system of evaluating the suitability of forest park tourism products,obtained the weight of every index by using Analyses of Hierarchical Process(AHP),and elucidated the score principle of final hierarchy indexes.Based on these analyses,a synthetic model of evaluating suitability of forest park tourism product was established.The indexes system was composed of four hierarchies.B hierarchy included product's competitiveness,market demand level,developing performance,product developing capability and external relationship.C,D hierarchy included twenty-six factors.In the end,the paper had evaluated the suitability of what the Fuzhou forest park would develop a climbing mountain tourism product.The evaluating outcome showed that the climbing mountain tourism product would be very suitable to develop in Fuzhou forest park,and the outcome was consistent with the actual outcome,which validated the rationality of the evaluation model.",
        "keywords": [
            "tourism product evaluation",
            "forest park",
            "evaluation model",
            "tourism product development"
        ],
        "authors": [
            {
                "name": "Huang Xiujuan",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University Fuzhou "
            },
            {
                "name": "Liu Weiping",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University Fuzhou "
            },
            {
                "name": "Lan Siren",
                "org": "Fujian Forestry Office Fuzhou "
            }
        ],
        "venue": "Scientia Silvae Sinicae",
        "year": 2009
    },
    "xL8yZXah": {
        "id": "xL8yZXah",
        "title": "Analysis of the Attributes on Forest Carbon Production",
        "abstract": "Forest carbon Production is an inexpensive option to mitigate global warming.Discusses the connotation of the forest carbon production.Points out the natural attributes are derived from the forest on the whole has the function of absorbing carbon dioxide.The economic attributes are consisted of public goods characteristics,external characteristics,and scarcity characteristics.The social attributes are composed by the impaction of ecological environment,economic development,forest managers' income,employment,etc.And these three attributes are mutual contact influence each other.",
        "keywords": [
            "social attributes",
            "carbon sequestration",
            "carbon production",
            "forest",
            "natural attributes",
            "economic attributes"
        ],
        "authors": [
            {
                "name": "JIAN Gai-yuan",
                "org": "Economics and Management College of FAFU,Fuzhou  China"
            },
            {
                "name": "FENG Liang-ming",
                "org": "Economics and Management College of FAFU,Fuzhou  China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Economics and Management College of FAFU,Fuzhou  China"
            }
        ],
        "venue": "Issues of Forestry Economics",
        "year": 2011
    },
    "9QXGGieE": {
        "id": "9QXGGieE",
        "title": "Study on the Mechanism of Forest Resources Protection by the Forestry Tenure Reform",
        "abstract": "After forest tenure reform, the protection of forest resources has a different mechanism. The farmers willing to protect their private property is stronger than to protect public resources, so illegal logging phenomenon can be forbidden effectively. The characteristics and impact extention of forestry income induce that the farmers to carry out logging less than the collective management. Transaction costs raised led by property rights scattered reduce the logging transaction and also an effective mechanism for the protection of forest resources. Farmers choose to operate, protect forest resources relied on land and on the \"home\" culture.",
        "keywords": [
            "forest resources protection",
            "mechanism",
            "forst tenur reform"
        ],
        "authors": [
            {
                "name": "Feng Liangming",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou "
            },
            {
                "name": "Liu Weiping",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou "
            }
        ],
        "venue": "Forestry Economics",
        "year": 2009
    },
    "fgTSlymn": {
        "id": "fgTSlymn",
        "title": "On Market Mechanism of Ecological Benefit Compensation of Non-commercial Forest",
        "abstract": "Paper simply expounds theory and practice of ecological benefit market compensation of non-commercial forest.Put forward some suggestions for ecological benefit market compensation of non-commercial forest in China,such as defining ecological property right,reducing deal cost,providing correlated information and innovating correlated system.Meanwhile,the paper put forward that certain ecological rights,which take the place of ecological product of non-commercial forest,can be regarded as market trade objection of ecological benefit of non-commercial forest.Analyzes ideology and its education effect on market trade of ecological benefit compensation of non-commercial forest.",
        "keywords": [
            "compensation",
            "market mechanism",
            "ecological benefit",
            "non-commercial forest"
        ],
        "authors": [
            {
                "name": "CHEN Qin",
                "org": "Economy and Management College of Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Economy and Management College of Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China"
            }
        ],
        "venue": "Research of Agricultural Modernization",
        "year": 2006
    },
    "9wYgqZN7": {
        "id": "9wYgqZN7",
        "title": "The Research on the Construction of the System of Modern Agriculture of Fujian",
        "abstract": "Modern agriculture own strong function\u3001content connotation and enormorous effect of wealth , based on the clear recognition of modern agriculture connotation and feature ,the article analyze profoundly the advantage and disadvantage to step up the construction of the system of modern agriculture of Fujian,put forward construction of the system of modern agriculture of Fujian with the core of industry innovation.",
        "keywords": [
            "involved agriculture",
            "Fujian",
            "modern agriculture"
        ],
        "authors": [
            {
                "name": "LIU Fei-xiang",
                "org": "College of economics and management, Fujian Agriculture and Forestry University,Fuzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "College of economics and management, Fujian Agriculture and Forestry University,Fuzhou ,China"
            }
        ],
        "venue": "Science Technology and Industry",
        "year": 2007
    },
    "PHSQbEH4": {
        "id": "PHSQbEH4",
        "title": "A Study on the Carbon Emissions Trading Based on Forest Resources Management",
        "abstract": "China's forest resources management has its own characteristics and has made a contribution to decease global warming.The \"Kyoto Protocol\"shows that forest has functions to offset greenhouse gas emissions,but also notices that China's forest resources management and climate change problems should regard as a whole.To ensure China's economic security and the forest eco-economic system play its function,it has proposed that establishment a voluntary domestic carbon emissions trading market and Innovation trading mechanisms to promotion that forest enters the framework of the market.",
        "keywords": [
            "forest resources management",
            "carbon Emissions trading",
            "climate change"
        ],
        "authors": [
            {
                "name": "FENG Liang-ming",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            },
            {
                "name": "XIAO You-zhi",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            }
        ],
        "venue": "Issues of Forestry Economics",
        "year": 2009
    },
    "c6L7e981": {
        "id": "c6L7e981",
        "title": "Analyzing Income and Risk of Plantation in Fujian Province",
        "abstract": "Investors always expect to invest the item of higher income and lower risk. Plantation income and risk can affect investment quantities. Beforetime, people believe that plantation income is lower. However, in recent years, because of reduction of timber tax and fee and policy to support forestry coming on, plantation income rate have enhanced and private forest have developed speedily. It may be demonstrated in Fujian Province. Bankers and potential investors are afraid of plantation risks, for example fire and diseases and insects, and are short of confidence for plantation investment. To analyze plantation risk of Fujian Province by real data, the paper concludes that from 1993 to 2002, average nature risk loss of plantation is lower in Fujian Province. Nevertheless, if a private forest happens fire or has diseases and insects, he will lose. Therefore, government must establish system to decentralize risks.",
        "keywords": [
            "risk",
            "system",
            "financing",
            "income",
            "plantation"
        ],
        "authors": [
            {
                "name": "Chen Qin",
                "org": "Economy and Management Department of Fujian Agriculture and Forestry University Fuzhou "
            },
            {
                "name": "Liu Weiping",
                "org": "Economy and Management Department of Fujian Agriculture and Forestry University Fuzhou "
            }
        ],
        "venue": "Scientia Silvae Sinicae",
        "year": 2006
    },
    "cU1YvhVe": {
        "id": "cU1YvhVe",
        "title": "Empirical Study on performance of Reform of Collective Forest Rightsin Yong'an City",
        "abstract": "Under the comprehensive carrying out and deepened collective ownership of Forests system reform background,the earlier period reform implementation situation and the result become the hot spot of research day by day.This article depends on the investigation situation of the national forestry Bureau collective ownership of forests system reform track monitor topic,take Yong'an city Fujian Province as the object of study,from the input and output of forest land management,circulation of forest land,degree of satisfaction with collective ownership of forests system reform,policy demand and so on,discussion achievements of collective ownership of forests system Reform.The findings discovered that,The collective ownership of Forests System Reform increased forest worker's forestry production income,has opened up the forestry financing channel;simultaneously also causes the forestry investment increasing,the forestry cooperative organization's appearance and the enhancement.Finally pointed out the public policies that would improve the performance of Reform of collective forest rights in Yong'an city.",
        "keywords": [
            "reform of collective forest rights",
            "Yong'an city",
            "collective forest"
        ],
        "authors": [
            {
                "name": "Huang Ying",
                "org": "Economics and management college of Fujian Agriculture and Forestry University,Fuzhou  China"
            },
            {
                "name": "Liu wei-ping",
                "org": "Economics and management college of Fujian Agriculture and Forestry University,Fuzhou  China"
            }
        ],
        "venue": "Issues of Forestry Economics",
        "year": 2011
    },
    "5z0WPfFR": {
        "id": "5z0WPfFR",
        "title": "A Perspective on the Progress of Forest Park Research through Statistical Analysis of the Articles Published in Domestic Core Journals",
        "abstract": "Based on the sources of CAJ Full-text Database,the paper tries to search for the articles of forest park published from January,1992 to December,2011 and makes statistical analysis of the distribution of these articles in terms of time,space,publications,writers,posting units,the number of citations and contents so as to provide a perspective on the progress of domestic forest park research in the past twenty years.",
        "keywords": [
            "literature analysis",
            "Chinese core journals",
            "forest park research"
        ],
        "authors": [
            {
                "name": "CHEN Xiao-qin",
                "org": "Economics and management college of Fujian agriculture and forestry university,Fuzhou,Fujian  China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Economics and management college of Fujian agriculture and forestry university,Fuzhou,Fujian  China"
            },
            {
                "name": "CHEN Gui-song",
                "org": "Economics and management college of Fujian agriculture and forestry university,Fuzhou,Fujian  China"
            }
        ],
        "venue": "Issues of Forestry Economics",
        "year": 2012
    },
    "EaDTfFOo": {
        "id": "EaDTfFOo",
        "title": "The Factors Affecting Tea Farmers' Investment Behavior:A Positive Analysis of Anxi County,Fujian Province",
        "abstract": "On basis of the survey data of farmers in Anxi County,Fujian Province,this paper establishes the double logarithmic model and analyzes the affecting factors of the tea farmers' investment behavior.Studies have shown that tea garden area,total household income farmers,tea income in the proportion of total household income,as well as regional differences in investment behavior of farmers are positive impacts;while the number of labor force of farmers families is the negative impact;the risk awareness of farmers is not significant.Therefore,it is of great importance to increase the income of the tea farmers.",
        "keywords": [
            "influencing factors",
            "tea farmers",
            "investment behavior",
            "positive study"
        ],
        "authors": [
            {
                "name": "SU Bao-cai",
                "org": "Economics and Management College,Fujian Agriculture And Forestry University,Fuzhou ,Fujian,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Economics and Management College,Fujian Agriculture And Forestry University,Fuzhou ,Fujian,China"
            }
        ],
        "venue": "Journal of Central South University of Forestry & Technology(Social Sciences)",
        "year": 2009
    },
    "NSBAHtRs": {
        "id": "NSBAHtRs",
        "title": "Analysis of the Incentive Mechanism on Forest Carbon Production",
        "abstract": "Forest carbon production is low-cost options in the adaptation and mitigation of global climate change,that encourage the production of forest carbon because of its economic attributes,including the production of public goods characteristics and positive externalities.The thesis uses the supply and demand curves to economically explain the forest carbon production,analyses property rights arrangements and carbon price payment as incentives for forest carbon production,points out the practical difficulties in the incentive of property rights arrangements,to expedite the introduction of a carbon tax,and then play the role of carbon pricing mechanism,optimize the allocation of resources in forest carbon production.",
        "keywords": [
            "incentive",
            "carbon emission",
            "carbon production",
            "forest"
        ],
        "authors": [
            {
                "name": "JIAN Gai-yuan",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            },
            {
                "name": "FENG Liang-ming",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            }
        ],
        "venue": "Issues of Forestry Economics",
        "year": 2012
    },
    "njMfMbkL": {
        "id": "njMfMbkL",
        "title": "Empirical Research on Scale Efficiency of Tobacco Leaf Based on DEA:Taking Fujian Province as a Case",
        "abstract": "It is necessary to research the appropriate scale size for the development of modern tobacco agriculture.Therefore,from the micro level the objectives of this article are to survey cultivation data of tobacco farmers by the scientific methods,to evaluate the planting scale efficiency of tobacco farmers of different scale ranges by Data Envelopment Analysis method,to reveals the relationship of the tobacco-planting scale and the efficiency.The main conclusion and suggestion: tobacco farmer should be actively guided to choose best moderate scale of planting by the standard of efficient scale;tobacco farmer should be guided scientifically planting with respecting to willingness of farmer and improving the planting scale efficiency;different areas must regular evaluate efficient scale as a moderate scale of local standards.",
        "keywords": [
            "DEA",
            "tobacco farmer",
            "scale efficiency",
            "modern tobacco agriculture"
        ],
        "authors": [
            {
                "name": "Zhang Hongyong",
                "org": "College of Economy and Management,Fujian Agriculture and Forestry University,Fuzhou ,China;China National Tobacco Corporation Fujian Company,Fuzhou ,China"
            },
            {
                "name": "Liu Weiping",
                "org": "College of Economy and Management,Fujian Agriculture and Forestry University,Fuzhou ,China"
            }
        ],
        "venue": "Value Engineering",
        "year": 2011
    },
    "6tCSwDw3": {
        "id": "6tCSwDw3",
        "title": "Empirical study of the credit rationing suffered by the agricultural leading enterprises in Fujian",
        "abstract": "Using statistics data of yearbook,this paper measures the credit rationing situation suffered by agricultural leading enterprises above the city-level in Fujian,and examines the credit rationing efficiency to agricultural leading enterprises made by banking institutions by using Panel-Data-Model.The results show that:the credit rationing degree suffered by agricultural leading enterprises above the city-level in Fujian is high and is deteriorating gradually,the credit rationing degree varies with different regions;the credit rationing efficiency to agricultural leading enterprises made by banking institutions is relatively high.",
        "keywords": [
            "credit rationing",
            "agricultural leading enterprise",
            "rationing efficiency"
        ],
        "authors": [
            {
                "name": "ZHENG Hui-ming",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China"
            }
        ],
        "venue": "Journal of Fujian Agriculture and Forestry University(Philosophy and Social Sciences)",
        "year": 2013
    },
    "d3GZS7hN": {
        "id": "d3GZS7hN",
        "title": "Discussion of the Chinese Enterprise Green Strategy",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Liu Wei-ping",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou,Fujian 350002 China)"
            }
        ],
        "venue": "Problems of Forestry Economics",
        "year": 2004
    },
    "NyKGSBtg": {
        "id": "NyKGSBtg",
        "title": "Discussion on Scale Development of Low-carbon Businesses in Fujian",
        "abstract": "The paper analyzes the current situations and the existing issues of the scale development of low-carbon businesses in Fujian,and puts forward the countermeasures which include developing and growing low-carbon businesses,enhancing the low-carbon brand establishment of local businesses,perfecting the low-carbon industrial chain,constructing legal supervision and incentive mechanism,and taking different approachfor different low-carbon businesses.",
        "keywords": [
            "scale development",
            "low-carbon brand",
            "low-carbon business"
        ],
        "authors": [
            {
                "name": "SHI Qiao-ling",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou,Fujian,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou,Fujian,China"
            },
            {
                "name": "LI Huan-ting",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou,Fujian,China"
            },
            {
                "name": "CHEN Yan-huang",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou,Fujian,China"
            },
            {
                "name": "CHEN Lin",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou,Fujian,China"
            },
            {
                "name": "ZHUANG Pei-fen",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou,Fujian,China"
            }
        ],
        "venue": "Taiwan Agricultural Research",
        "year": 2013
    },
    "LX27lMBM": {
        "id": "LX27lMBM",
        "title": "Investigation on Wetland Resources and Legislation Issues in Fujian Province",
        "abstract": "Investigation on wetlands conservation is the base of wetlands\u2019 legislation. Took wetland investigation of Longhai as anexample, the paper introduced the wetlands\u2019 usefulness, main existing problems, current conservation systems, problems of relevantlaws and regulations that are currently enforced in wetland management and protection. Based on the investigation, the authorsdiscussed some problems in wetlands\u2019 legislation in Fujian Province.",
        "keywords": [
            "Wetland management",
            "Wetland conservation",
            "Fujian Province",
            "Wetland legislation"
        ],
        "authors": [
            {
                "name": "LIU Wei-Ping",
                "org": " Economics and Management College of Fujian Agriculture and Forestry University, Fuzhou  China"
            },
            {
                "name": "RUAN Yun-Qiu",
                "org": " Wildlife Center of Fujian Forestry Department, Fuzhou  China"
            },
            {
                "name": "ZHANG Jian-Hua",
                "org": " Economics and Management College of Fujian Agriculture and Forestry University, Fuzhou  China"
            },
            {
                "name": "ZHOU Dong-Liang",
                "org": " Wildlife Center of Fujian Forestry Department, Fuzhou  China"
            }
        ],
        "venue": "Wetland Science &  Management",
        "year": 2006
    },
    "Xxsgiqcn": {
        "id": "Xxsgiqcn",
        "title": "Analysis of the Production Capacity of Woody Grain and Oil Based on Calculation of Food Equivalent Unit",
        "abstract": "It is of significance to develop woody of grain and oil industry based on current situation.The paper builds the food equivalent unit formula.Based on the collection of 30 years of production data of woody grain and oil products,the paper calculates the substitution of woody grain and oil to rice and the cultivated land during the 30 years.Then using statistical analysis software Eviews to forecast and analyze woody grain and oil's future production capacity and the potential capacity of replacing of rice and cultivated land.",
        "keywords": [
            "food equivalent unit",
            "woody grain and oil",
            "substitution"
        ],
        "authors": [
            {
                "name": "Hong Yanzhen",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou "
            },
            {
                "name": "Yu Jianhui",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou "
            },
            {
                "name": "Dai Yongwu",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou "
            },
            {
                "name": "Liu Weiping",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou "
            }
        ],
        "venue": "Forestry Economics",
        "year": 2010
    },
    "klT0qBRX": {
        "id": "klT0qBRX",
        "title": "A comment on the study of innovative agricultural technology development",
        "abstract": "Current studies on the system that fosters technological innovation for agriculture tended to focus on the technology per se.They concentrated on the research,extension and promotion with an aim to resolve the conflicts existing in the supply and demand of agriculture related technologies.There is a lack of classification of the technologies,and no explicit proposals for applications.In their eyes,agriculture extension was a one-way street for technical transfer,rather than communication between the providers and the applicators.Few study endeavored in the informal forms of technological development and promotion.Little attention was paid to the real technical needs of the farmers or the business assistance required by the farming communities.In this study on the development of innovative agricultural technologies,there needs to be a systematic design which can encourage and excite all parties involved.",
        "keywords": [
            "innovation system",
            "technical supplies",
            "technical promotion",
            "Agricultural technology",
            "technical demand"
        ],
        "authors": [
            {
                "name": "WANG Wen-lan",
                "org": "Economic and Management College,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Economic and Management College,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China"
            },
            {
                "name": "YIN Xiao-ke",
                "org": "Economic and Management College,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China"
            },
            {
                "name": "JIAN Gai-yuan",
                "org": "Economic and Management College,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China"
            }
        ],
        "venue": "Fujian Journal of Agricultural Sciences",
        "year": 2008
    },
    "N3wEBXZu": {
        "id": "N3wEBXZu",
        "title": "Research Progress of Forestry Economy in China for the Past Ten Years and Its Future Direction",
        "abstract": "Under the background of public financial investment,the implementation of forestry ecological projects of natural forest preservation and Returning Land for Farming to Forestry fulfills multiple managerial goals on forest and brings about tremendous changes on forestry output and structure.Forestry scholars follow the changes in good timing but there are pending scientific issues on the choice process of forestry managerial goals and constraints.The paper elaborates that market mechanism plays its full role as resource allocation in forest cultivation,processing of forestry products and management of forestry businesses.Changes on functions and modes of public administration in public forestry sectors further improve resource allocation.The paper indicates that scholars have considerate study on this institutional change but significant discoveries are not adequate.Through the analysis on the papers published in Issues on Forestry Economics,the paper concludes that future studies should be built on the practices in forestry economic activities and the accumulation of data and importance should be attached to the choice of research fields,applicable theories and econometric tools.",
        "keywords": [
            "research direction",
            "research methods",
            "forestry economic",
            "research progress"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            },
            {
                "name": "FENG Liang-ming",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            },
            {
                "name": "DAI Yong-wu",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            }
        ],
        "venue": "Issues of Forestry Economics",
        "year": 2008
    },
    "5z6PNK1p": {
        "id": "5z6PNK1p",
        "title": "Law-economics analysis of the law conflict in forest ecological benefit compensation system",
        "abstract": "Posner model in the law-economics analysis(legal economic analysis) is applied to deal with the law conflict in forest ecological benefit compensation system,meanwhile according to the manager\u2032s cost and income,the economic logic implied in the law conflict in forest ecological benefit compensation system is explored.",
        "keywords": [
            "income",
            "law-economics",
            "cost",
            "forest ecological benefit compensation system"
        ],
        "authors": [
            {
                "name": "LIN Xiu-feng",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China"
            }
        ],
        "venue": "Journal of Fujian Agriculture and Forestry University(Philosophy and Social Sciences)",
        "year": 2013
    },
    "OAZPwrRS": {
        "id": "OAZPwrRS",
        "title": "Summary of Study on Mortgage Loan Using Forest Property",
        "abstract": "The paper summarizes the connotation,spirit,principle and operation mechanism,function,effectiveness,constraining factors,suggestions for policy,in views of forestry property rights mortgage loan.Proposed the future research needed to be focused on.",
        "keywords": [
            "summary",
            "forestry property rights mortgage loan",
            "study",
            "credit"
        ],
        "authors": [
            {
                "name": "Yang Yun",
                "org": " Economics and Management School of Fujian Agriculture and Forestry University,Fuzhou ; Forestry Department of Fujian Province,Fuzhou "
            },
            {
                "name": "Liu Weiping",
                "org": " Economics and Management School of Fujian Agriculture and Forestry University,Fuzhou "
            }
        ],
        "venue": "Forestry Economics",
        "year": 2009
    },
    "IxQQC9jR": {
        "id": "IxQQC9jR",
        "title": "Influence of collective forestry property rights system reform on farmers\u2032 forestry income",
        "abstract": "Based on brief introduction of the current status of collective forestry property rights system reform and farmers\u2032 forestry income,taking Fujian and Jiangxi as the cases,and according to the results of analysis and practical data proving,the forestry property rights system reform has significantly increased the farmers\u2032 forestry income.Besides that,reduction and remission of the forestry tax and fee as well as the timber prices going up have increased the farmers\u2032 forestry income.Nevertheless the forestry property rights system reform has decreased financial income of towns and villages.",
        "keywords": [
            "forestry income",
            "farmer",
            "reform",
            "forestry property rights"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China"
            },
            {
                "name": "CHEN Qin",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China"
            }
        ],
        "venue": "Journal of Fujian Agriculture and Forestry University(Philosophy and Social Sciences)",
        "year": 2009
    },
    "QH3nyRJC": {
        "id": "QH3nyRJC",
        "title": "A Study on Legal Conflict of Forest Ecological Benefit Compensation System",
        "abstract": "There are serious legal conflicts of current forest ecological benefit compensation system.The normative documents of the State Forestry Administration and the Ministry of finance are to collide with the \"constitution\",\"general principles of civil law\",\"property law\",\"legislative law\",\"forest law\",etc.This paper gives a detailed description on the conflict of laws.The essence of legal conflict of forest ecological benefit compensation system is to ignore the property rights of farmers.",
        "keywords": [
            "legislative process",
            "conflict of laws",
            "forest ecological benefit compensation system"
        ],
        "authors": [
            {
                "name": "LIN Xiu-feng",
                "org": "Economic and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Economic and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            }
        ],
        "venue": "Issues of Forestry Economics",
        "year": 2013
    },
    "rCxnDAtX": {
        "id": "rCxnDAtX",
        "title": "Efficiency Analysis of Fujian Collective Forest Property Reform",
        "abstract": "Fujian province conduct the system of collective forest rights property reform first,one of the important objectives of the reform is achieve the number of forest resources growth and quality improvement,that is realizes the effective of the system of collective forest property rights reform. However,through the statistical analysis of survey data of the system of collective forest property rights reform in Fujian found that,the system of collective forest property rights reform in Fujian haven't met the efficiency of the targets. The lag of realize the target reflect the conflict between forestry family businesses and large-lscale forest management requirements,is also reflect the conflict between forestry family businesses system and other forestry policies.",
        "keywords": [
            "statistic",
            "rights",
            "collective forest"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": " Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            },
            {
                "name": "WANG Wen-lan",
                "org": " Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            }
        ],
        "venue": "Issues of Forestry Economics",
        "year": 2009
    },
    "e3iGgH1w": {
        "id": "e3iGgH1w",
        "title": "Study on the Utilization Ratio of Land of Magnolia biloba(Rehd et Wils) Cheng,and Phellodendron amurense Rupr. Forest Intercropped with Maize and Beans",
        "abstract": "The core meaning of study on the land utilization ratio is that can alleviate the land resource endowment scarce.Developing Magnolia biloba(Rehd et Wils) Cheng forest,and Phellodendron amurense Rupr.forest intercropped with maize and beans may raise the land utilization ratio,promoting forestry producer intensive farming,protects the biodiversity effectively,promoting Traditional Chinese Medicine industry development,increasing forest worker's economic gain,and promotes the social sustainable developmen.",
        "keywords": [
            "biodiversity",
            "Magnolia biloba(Rehd et Wils) Cheng forest",
            "Sustainable development",
            "intercropping",
            "intensive operation of economy",
            "Land equivalent ratio",
            "Phellodendron amurense Rupr.forest"
        ],
        "authors": [
            {
                "name": "HOU Chang-hong",
                "org": "Fujian Agriculture and Forestry University a.Economics and Management College"
            },
            {
                "name": "LIN Guang-mei",
                "org": "Fujian Agriculture and Forestry University a.Economics and Management College"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Fujian Agriculture and Forestry University a.Economics and Management College"
            }
        ],
        "venue": "Issues of Forestry Economics",
        "year": 2010
    },
    "md3YyJ37": {
        "id": "md3YyJ37",
        "title": "A Thinking on the Development in the Biomass-energy Industry Based on Energy Security and the Environment",
        "abstract": "Energy is an important material basis for human survival and development,the economic development level and its stage and energy utilization and efficiency are inseparable.the author study from energy strategy and the research significance,by an empirical analysis on energy security and efficiency in China,proposed that the ecological civilization rises with an inevitable trend of the biomass-energy industry development,In the last part of this paper,a thinking on the existent mechanism of new energy and the bio-energy policy policy.",
        "keywords": [
            "energy security",
            "industry",
            "biomass-energy"
        ],
        "authors": [
            {
                "name": "LIU Fei-xiang",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou ,China"
            }
        ],
        "venue": "Science Technology and Industry",
        "year": 2009
    },
    "ITFZJ4AF": {
        "id": "ITFZJ4AF",
        "title": "Construction and Evaluation on Model of Sustainable Development of Biomass Energy Policy in Fujian",
        "abstract": "Based on the sustainable development goal of biomass energy policy,this paper constructs a index system of evaluating the sustainable development of biomass energy policy,which reflects the essential characteristics,inherent laws and evolution trend of sustainable development of biomass energy policy.Evaluation result shows that the whole performance of biomass energy policy in Fujian is still at the initial stage of sustainable development,and government should strengthen the construction of energy market mechanism and promote the green energy consumption.",
        "keywords": [
            "energy policy",
            "sustainable development",
            "biomass energy"
        ],
        "authors": [
            {
                "name": "Liu Feixiang",
                "org": "College of Crop Science,FAFU,Fuzhou ,China"
            },
            {
                "name": "Liu Weiping",
                "org": "College of Economics and Management,FAFU,Fuzhou ,China"
            }
        ],
        "venue": "Technology Economics",
        "year": 2011
    },
    "1I6X9wps": {
        "id": "1I6X9wps",
        "title": "Study on the Collective Forests Property Rights Institutional Transformation of Sanming City",
        "abstract": "The paper objectively records the reform history on the property rights institution of collective forests in Sanming over the past twenty years.The paper analyzes the outcomes and driving forces from the household operation reform to the institutional transformation of board of shareholders in the background of forestry reform in the southern collective forestry areas at the early stage of China's rural reform.The paper analyzes the waning of forces supporting collective operation institution for the collective forests and the strengthening of the market forces in allocating resources in the course of adjustments of forestry board of shareholders and the formation of independent operation institution by farm households and individual farmers.The paper verifies that the constraint changes are the rules underlying the different institutional arrangements on property rights of collective forests.",
        "keywords": [
            "collective forests",
            "institutional transformation",
            "property rights"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "Economics and Management College of Fujian Agriculture and Forestry University,Fuzhou  China"
            }
        ],
        "venue": "Problems of Forestry Economics",
        "year": 2006
    },
    "mEu9HjeF": {
        "id": "mEu9HjeF",
        "title": "Cognition,Mode and Policy Guarantees of Forest Carbon Production",
        "abstract": "With the process of human civilization,forest production practice has transformed the patterns of utilization;utilizing forest to reduce carbon emission is nowadays widely concerned in response to global climate change.As a specific form of utilizing forest for less carbon emission,forest carbon production is actually a practice progress of forest ecological civilization.Based on this understanding,from ecological,social and economic aspects,this study makes an effort to probing into forest carbon production,and analyzes four kinds of major carbon production methods:afforestation,forest disaster prevention,harvesting delay,and changes of land use.Finally,this paper proposes four policy guarantees:promoting artificial afforestation incentive policies,improving logging quota system,enforcing appropriate carbon taxes and carbon offset policies,and establishing an effective carbon emission trading system,so as to better the important role that forest plays in global climate change.",
        "keywords": [
            "forest carbon production",
            "carbon production methods",
            "utilizing forest to reduce carbon emission",
            "climate change"
        ],
        "authors": [
            {
                "name": "JIAN Gai-yuan",
                "org": "Economics and Management College of FAFU,Fuzhou  China"
            },
            {
                "name": "WANG Wen-lan",
                "org": "Economics and Management College of FAFU,Fuzhou  China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Economics and Management College of FAFU,Fuzhou  China"
            },
            {
                "name": "FENG Liang-ming",
                "org": "Economics and Management College of FAFU,Fuzhou  China"
            }
        ],
        "venue": "Issues of Forestry Economics",
        "year": 2012
    },
    "e6kKTOrE": {
        "id": "e6kKTOrE",
        "title": "Analysis on Cultivation Potentiality of Chinese Camellia Oleifera Abel\u2014\u2014 Based on Survey Data of Farming Houshold in Fujian",
        "abstract": "Based on the theory of optimal production,the paper takes use of survey data of input and output of Ca mellia oleifera Abel parcel to construct Camellia oleifera Abel supply decision model which is based on the estimat ed production function.Then it uses LINGO planning software program to solve optimal Camellia oleifera Abel growing area,the most excellent input and output levels and the possible supply potentiality.The results show that the current Camellia oleifera Abel production did not reach the optimal level of input and output,and there is big room for improvement of supply and profit.But in the current operating level,even takeing all the barren hills which are suitable for growing Camellia oleifera Abel to plant Camellia oleifera Abel,the future supply of Camellia oleifera Abel is also difficult to achieve the Camellia oleifera Abel planning objectives.So it is necessary to probe strategies of improving the per unit yield of Camellia oleifera Abel.",
        "keywords": [
            "optimum decision",
            "potentiality",
            "farming houshold",
            "Camellia oleifera Abel planting"
        ],
        "authors": [
            {
                "name": "Hong Yanzhen",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou "
            },
            {
                "name": "Liu Weiping",
                "org": "College of Economics and Management,Fujian Agriculture and Forestry University,Fuzhou "
            }
        ],
        "venue": "Forestry Economics",
        "year": 2012
    },
    "WVfTur0b": {
        "id": "WVfTur0b",
        "title": "Strategy of the agricultural industrialization in Shaowu City",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Liu Wei-ping",
                "org": "College of Economics and Management, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002,China)"
            }
        ],
        "venue": "Journal of Fujian Agriculture University",
        "year": 2004
    },
    "oSmgKxwX": {
        "id": "oSmgKxwX",
        "title": "Preparation of Magnesium Oxide with Silico-steel Grade from Bischofite",
        "abstract": "Using bischofite as raw material,the preparation of magnesium oxide with silico-steel grade was studied.The effects of reaction temperature,reaction pH value and aging time on the intermediate magnesium hydroxide purity and conversion rate were studied.Calcinations temperature,calcinations time relationship to the hydration rate of MgO and amount of additive to the suspension performance of MgO were investigated.The results indicated that the optimum technological conditions were as follows:reaction temperature is 55 \u2103,reaction pH value is 9.5,aging time is 2h,the calcinations temperature is 1050\u2103 and the calcinations time is 2h.The amount of additive is 0.8%.The results show that the purity of magnesium oxide is 98.99%,the hydration rate is 2.92% and the suspension performance is 3mm/h which meet the requirements of magnesium oxide with sillico-steel grade.",
        "keywords": [
            "magnesium oxide with silico-steel grade",
            "ammonia",
            "magnesium hydroxide",
            "bischofite"
        ],
        "authors": [
            {
                "name": "XU Hui",
                "org": ""
            },
            {
                "name": "CHENG Junfeng",
                "org": ""
            },
            {
                "name": "LI Gui",
                "org": ""
            },
            {
                "name": "YANG Xiyun",
                "org": ""
            },
            {
                "name": "LIU Weiping",
                "org": ""
            }
        ],
        "venue": "Materials Review",
        "year": 2013
    },
    "BM7EH7u9": {
        "id": "BM7EH7u9",
        "title": "Study on Microwave Synthesis and Properties of LiFePO_4/C Cathode Materials",
        "abstract": "The LiFePO4/C cathode materials for lithium-ion battery were synthesized by means of mechanical ball-milling and microwave processing.The effects of different C-suppliers and the amounts of C-coating on the crystalline structure,morphology of particles and electrochemical properties of the resultant products were investigated by X-ray diffraction,scanning electro-microscopy and constant current charge-discharge test.The experimental results reveal that LiFePO4/C cathode material can be synthesized quickly by microwave processing.And the sample synthesized with 8wt% acetylene black shows the best electrochemical performance.The intial specific discharge capacity is 148.44mAh/g achieved in the charge-discharge test(20mA/g) at room temperature and its specific discharge capacity keeps 144.74mAh/g by 97.51% after 10 times cycling.",
        "keywords": [
            "lithium-ion batteries",
            "microwave sythesis",
            "cathode material",
            "electrochemical performance",
            "C-coating",
            "LiFePO4/C"
        ],
        "authors": [
            {
                "name": "XU Hui",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha "
            },
            {
                "name": "LIU Weiping",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha "
            },
            {
                "name": "SU Yuanzhi",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha "
            },
            {
                "name": "YANG Xiyun",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha "
            }
        ],
        "venue": "Materials Review",
        "year": 2011
    },
    "miL0r0ue": {
        "id": "miL0r0ue",
        "title": "Effects of Base Liquid on the Settlement Property of Mg(OH)_2 Prepared by Lime Method",
        "abstract": "The Mg(OH)2 synthesized from magnesium chloride and lime water via four kinds of injection: positive,reverse,double,double-basic liquid,and the latter was the best way.Effects of the mass percentage concentration and volume of calcium chloride solution on the sedimentation property of the Mg(OH)2 were researched,the optimal conditions were 15%,50 mL.The influence of different reaction system\u2032s instantly activity product on the sedimentation property of the Mg(OH)2 were explored,following the increase of mass percent concentration and volume of CaCl2 solution,the super saturation of the reaction system can be maintained at a relatively low level.",
        "keywords": [
            "settlement property",
            "double-basic liquid",
            "super saturation",
            "solution activity product",
            "lime water",
            "magnesium hydroxide"
        ],
        "authors": [
            {
                "name": "LIU Weiping",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha "
            },
            {
                "name": "XU Hui",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha "
            },
            {
                "name": "CHENG Junfeng",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha "
            },
            {
                "name": "LI Gui",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha "
            },
            {
                "name": "SHI Xichang",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha "
            },
            {
                "name": "YANG Xiyun",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha "
            }
        ],
        "venue": "Materials Review",
        "year": 2012
    },
    "r205G0pu": {
        "id": "r205G0pu",
        "title": "Study on Synthesis of Li_(1-x)Cr_xFePO_4 by Microwave Processing",
        "abstract": "The Li1-xCrxFePO4 cathode materials for lithium-ion battery were synthesized by means of mechanical ball-milling and microwave processing.The effects of different ways of Cr3+-doping and the amounts of doped-Cr3+ on the crystalline structure,morphology of particles and electrochemical properties of the resultant products were investigated by XRD,SEM and constant current charge-discharge test.The experimental results reveal that a Li1-x-CrxFePO4 cathode material can be synthesized quickly by microwave processing.And the sample Li0.99Cr0.01FePO4 doped by co-precipitation method shows the best electrochemical performance.The initial specific discharge capacity is 153.59mAh/g in the charge-discharge test(20mA/g) at room temperature and its specific discharge capacity keeps 149.29mAh/g by 97.20% after 10 cycles.",
        "keywords": [
            "Cr3+-doping",
            "lithium-ion batteries",
            "microwave",
            "cathode material",
            "LiFePO4"
        ],
        "authors": [
            {
                "name": "XU Hui",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha "
            },
            {
                "name": "LIU Weiping",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha "
            },
            {
                "name": "SU Yuanzhi",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha "
            },
            {
                "name": "SHI Xichang",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha "
            },
            {
                "name": "YANG Xiyun",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha "
            }
        ],
        "venue": "Materials Review",
        "year": 2011
    },
    "J4pCIzKn": {
        "id": "J4pCIzKn",
        "title": "Thermodynamic equilibrium diagram of CaCl_2-Ca(OH)_2-H_2O system",
        "abstract": "The lg c-pH diagram of the CaCl2-Ca(OH)2-H2O system and its two subsystems at 298.15 K are constructed according to the theory of thermodynamic equilibrium.The interaction characteristics between the solubility of CaCl2 and Ca(OH)2 can be found out from the diagrams.CaCl2.6H2O(s),Ca(OH)2(s) and solution coexist when the pH value of solution is about 10.8.CaCl2 with the minimum solubility of 1 682.4 g/L is in equilibrium with solution when the pH value is lower than 9.4,and Ca(OH)2 with the minimum solubility of 2.749 g/L is in equilibrium with solution at the pH value over 12.1,which provides a theoretical basis for the treatment and reuse of calcium chloride mother liquor for collocating lime cream which is the precipitant in the process of synthesizing magnesium hydroxide.",
        "keywords": [
            "thermodynamic equilibrium",
            "lg c-pH diagram",
            "CaCl2-Ca(OH)2-H2O system",
            "solubility",
            "magnesium hydroxide"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": " School of Metallurgical Science and Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "XU Hui",
                "org": " School of Metallurgical Science and Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "YANG Xi-yun",
                "org": " School of Metallurgical Science and Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "SHI Xi-chang",
                "org": " School of Metallurgical Science and Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "CHEN Ya",
                "org": " School of Metallurgical Science and Engineering,Central South University,Changsha ,China"
            }
        ],
        "venue": "\u4e2d\u5357\u5927\u5b66\u5b66\u62a5(\u82f1\u6587\u7248)",
        "year": 2012
    },
    "AKY8Ihjg": {
        "id": "AKY8Ihjg",
        "title": "Equilibrium concentration of calcium hydroxide in CaCl 2-Ca(OH) 2-H 2O system",
        "abstract": "The c(CaCl 2)-c(Ca(OH) 2) chart and c(CaCl 2)-pH value chart in CaCl 2-Ca(OH) 2-H 2O system under 25\u00b0C were plotted. The results represent that c(Ca(OH) 2) and pH value decrease with the increase of c(CaCl 2), the trend of c(Ca(OH) 2) is supported by the calculation results of Debye-Huckel. When c(CaCl 2)<3.78 mol/L, the pH value of the system is bigger than 10.4, and CaClOH is preciptated while c(CaCl 2)>2.57 mol/L. Through calculation, the CaCl 2 mother liquor can reuse 132 times for collocating lime water in theory. The research results provide a theoretical basis for the treatment and reuse of calcium chloride mother liquor for collocating lime water which is the precipitant in the process of synthesizing magnesium hydroxide.",
        "keywords": [
            "CaCl 2 mother liquor",
            "CaCl 2-Ca(OH) 2-H 2O",
            "Lime water",
            "PH value",
            "Recycling"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "Central South University China(Central South University ^),Changsha,China"
            },
            {
                "name": "Hui Xu",
                "org": "Central South University China(Central South University ^),Changsha,China"
            },
            {
                "name": "SHI Xi-chang",
                "org": "Central South University China(Central South University ^),Changsha,China"
            },
            {
                "name": "YANG Xi-yun",
                "org": "Central South University China(Central South University ^),Changsha,China"
            },
            {
                "name": "Ya Chen",
                "org": "Central South University China(Central South University ^),Changsha,China"
            },
            {
                "name": "CHENG Jun-feng",
                "org": "Central South University China(Central South University ^),Changsha,China"
            },
            {
                "name": "Gui Li",
                "org": "Central South University China(Central South University ^),Changsha,China"
            }
        ],
        "venue": "Zhongguo Youse Jinshu Xuebao/Chinese Journal of Nonferrous Metals",
        "year": 2012
    },
    "PvzCtibw": {
        "id": "PvzCtibw",
        "title": "Preparation of high-purity light magnesia from sulfate salt subtype salt lake brine",
        "abstract": "Using sulfate salt subtype salt lake brine as raw materials,light-magnesia was prepared by the technology of ammonia precipitation,ammonium bicarbonate carbonation and calcination.The effects of the excessive coefficient of ammonium bicarbonate,concentration of ammonium bicarbonate,temperature of reaction and time of reaction on the carbonization ratio of ammonium bicarbonate were investigated,and the optimum process for preparation of light magnesia was obtained.The results show that the contents of element S and B are decreased,the apparent gravity is increased to 10 cm3/g,and the purity of magnesium oxide is greater than 99% due to carbonation,which is better than national standard of light magnesia.",
        "keywords": [
            "light magnesia",
            "basic magnesium carbonate",
            "sulfate salt subtype salt lake brine"
        ],
        "authors": [
            {
                "name": "XU Hui",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "YANG Xi-yun",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "SHI Xi-chang",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "CHEN Shi-yue",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "YU Liang-liang",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha ,China"
            }
        ],
        "venue": "Journal of Central South University(Science and Technology)",
        "year": 2011
    },
    "zmlmJBtP": {
        "id": "zmlmJBtP",
        "title": "Study on Solubility of MgO in Melt Salt",
        "abstract": "The solubility of the five melt salts such as NaF+NaCl,NaCl+cryolite,NaCl+NaF+cryolite,Na3PO3+NaF+NaCl and Na3PO3+NaCl+cryolite are studied.According to the results the five melt salt is sequenced by the extent of solubility as 1.2%,1.9%,2.1%,1.09%,6.04%,which is of significance to electrolyzing magnesia.",
        "keywords": [
            "Solubility",
            "Molten salt",
            "Magnesium oxide"
        ],
        "authors": [
            {
                "name": "XU Hui",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "DONG Rui",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "YANG Xi-yun",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "SHI Xi-chang",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "ZHAO Na",
                "org": "School of Metallurgical Science and Engineering,Central South University,Changsha ,China"
            }
        ],
        "venue": "Nonferrous Metals(Extractive Metallurgy)",
        "year": 2011
    },
    "MJVq7FyS": {
        "id": "MJVq7FyS",
        "title": "Measurement of 2H( 8Li, 9Be) n reaction relevant to primordial nucleosynthesis",
        "abstract": "The angular distribution of the 2H( 8Li, 9Be) n (ground state) reaction, important to primordial nucleosynthesis in the inhomogeneous model, has been measured at E c.m. \u2264 8.1 MeV using a secondary 8Li beam. Cross section of this reaction was determined to be 9.0\u00b13.4 mb. According to the cross section, the astrophysical S-factor was calculated to be 272\u00b1103 keV b. It is shown that 2H( 8Li, 9Be) n (ground state) reaction is important for creating 9Be, but less important for destroying 8Li in primordial nucleosynthesis. \u00a92005 Chinese Physical Society and IOP Publishing Ltd.",
        "keywords": [
            "cross section",
            "ground state"
        ],
        "authors": [
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2005
    },
    "xBiWRmRU": {
        "id": "xBiWRmRU",
        "title": "Direct measurement of the14O(\u03b1, \u03b1)14O cross section for astrophysically important 14O + \u03b1 resonances",
        "abstract": "For the study of astrophysically important states in 18Ne, the 140(\u03b1, a)140 cross section was measured in inverse kinematics using a radioactive 14O beam. This reaction was investigated for properties of resonant states of 18Ne for determining the 14O(\u03b1,p)17F reaction rate, which is one of the most important reactions for understanding the breakout mechanism from the Hot CNO cycle to the rp-process. Alpha-induced elastic scattering on 14O was performed using the lowenergy radioactive ion (RI) beam separator at the Center for Nuclear Study (CNS) in the RIKEN Accelerator Research Facility. The energy range Ex = 7.2-13.1 MeV of 18Ne was scanned with the thick target method. Recoiled alpha particles were measured with Si dE-E telescopes. Spins and widths of three resonances at Ex = 8.6, 9.22, and 10.06 MeV were calculated using the R-matrix analysis, and a new state of 18Ne at Ex = 12.0 MeV was found in this experiment.",
        "keywords": [
            "14O(\u03b1 \u03b1) 14O",
            "14O(\u03b1p) 17F",
            "18Ne",
            "Ri beam"
        ],
        "authors": [
            {
                "name": "Aram Kim",
                "org": "Ewha Womans University(Ewha Womans University),Seoul,South Korea"
            },
            {
                "name": "Namhee Lee",
                "org": "Ewha Womans University(Ewha Womans University),Seoul,South Korea"
            },
            {
                "name": "Insik Hahn",
                "org": "Ewha Womans University(Ewha Womans University),Seoul,South Korea"
            },
            {
                "name": "J. S. Yoo",
                "org": "Ewha Womans University(Ewha Womans University),Seoul,South Korea"
            },
            {
                "name": "M. H. Han",
                "org": "Ewha Womans University(Ewha Womans University),Seoul,South Korea"
            },
            {
                "name": "Shigeru Kubono",
                "org": "University of Tokyo(University of Tokyo),Tokyo,Japan"
            },
            {
                "name": "Hidetoshi Yamaguchi",
                "org": "University of Tokyo(University of Tokyo),Tokyo,Japan"
            },
            {
                "name": "Satoshi Hayakawa",
                "org": "University of Tokyo(University of Tokyo),Tokyo,Japan"
            },
            {
                "name": "Yasuo Wakabayashi",
                "org": "University of Tokyo(University of Tokyo),Tokyo,Japan"
            },
            {
                "name": "Dam Nguyen Binh",
                "org": "University of Tokyo(University of Tokyo),Tokyo,Japan"
            },
            {
                "name": "Hidenori Hashimoto",
                "org": "University of Tokyo(University of Tokyo),Tokyo,Japan"
            },
            {
                "name": "Takahiro Kawabata",
                "org": "University of Tokyo(University of Tokyo),Tokyo,Japan"
            },
            {
                "name": "Daid M. Kahl",
                "org": "University of Tokyo(University of Tokyo),Tokyo,Japan"
            },
            {
                "name": "Yosuke Kurihara",
                "org": "University of Tokyo(University of Tokyo),Tokyo,Japan"
            },
            {
                "name": "Youngkwan Kwon",
                "org": "Chung-Ang University(Chung-Ang University),Seoul,South Korea"
            },
            {
                "name": "Takashi Teranishi",
                "org": "Kyushu University(Kyushu University),Fukuoka,Japan"
            },
            {
                "name": "Seigo Kato",
                "org": "Yamagata University(Yamagata University,Yamagata Univ),Yamagata,Japan"
            },
            {
                "name": "Tetsuro Komatsubara",
                "org": "University of Tsukuba(University of Tsukuba),Tsukuba,Japan"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Journal of the Korean Physical Society",
        "year": 2010
    },
    "N9dO8Je8": {
        "id": "N9dO8Je8",
        "title": "New measurement of proton transfer reactions and elastic scattering for 7Li + 13C at 34 MeV",
        "abstract": "The 13C( 7Li, 6He) 14N reaction is measured at E( 7Li) = 34 MeV with the Q3D magnetic spectrometer of HI-13 tandem accelerator. Angular distributions at forward angles for proton transfer to the ground and the first excited states in 14N are obtained. In addition, angular distribution for 7Li + 13C elastic scattering is also measured. The optical potential parameters for the entrance and exit channels of the transfer reactions are derived by fitting the 7Li + 13C and 6Li + 14N elastic scattering experimental data, and their angular distributions are well reproduced by the distorted wave Born approximation calculations. A phase shift of about 2\u00b0 between the calculations and the experiment data has been found in the earlier ( 7Li, 6He) study, whereas no such phase shift is observed in the present work.",
        "keywords": [
            "angular distribution",
            "elastic scattering",
            "transfer reaction"
        ],
        "authors": [
            {
                "name": "YunJu Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Ertao Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhichang Li.",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "JianCheng Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xin Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "SunJun Jin",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Qiwen Fan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "\u7b49\u79bb\u5b50\u4f53\u79d1\u5b66\u4e0e\u6280\u672f(\u82f1\u6587\u7248)",
        "year": 2012
    },
    "oKsVRMAY": {
        "id": "oKsVRMAY",
        "title": "The nature of the lithium enrichment in the most Li-rich giant star",
        "abstract": "About 1% of giant stars1 have anomalously high Li abundances (ALi) in their atmospheres, conflicting directly with the prediction of standard stellar evolution models2. This finding makes the production and evolution of Li in the Universe intriguing, not only in the sense of Big Bang nucleosynthesis3,4 or the interstellar medium5, but also for the evolution of stars. Decades of effort have been put into explaining why such extreme objects exist6\u20138, yet the origins of Li-rich giants are still being debated. Here, we report the discovery of the most Li-rich giant known to date, with a very high ALi of 4.51. This rare phenomenon was observed coincidentally with another short-term event: the star is experiencing its luminosity bump on the red giant branch. Such a high ALi indicates that the star might be at the very beginning of its Li-rich phase, which provides a great opportunity to investigate the origin and evolution of Li in the Galaxy. A detailed nuclear simulation is presented with up-to-date reaction rates to recreate the Li enrichment process in this star. Our results provide tight constraints on both observational and theoretical points of view, suggesting that low-mass giants can internally produce Li to a very high level through 7Be transportation during the red giant phase.",
        "keywords": "",
        "authors": [
            {
                "name": "H. L. Yan",
                "org": "Key Laboratory of Optical Astronomy, National Astronomical Observatories, Chinese Academy of Sciences, Beijing, China"
            },
            {
                "name": "J. R. Shi",
                "org": "Key Laboratory of Optical Astronomy, National Astronomical Observatories, Chinese Academy of Sciences, Beijing, China"
            },
            {
                "name": "Yu-Tao Zhou",
                "org": "Key Laboratory of Optical Astronomy, National Astronomical Observatories, Chinese Academy of Sciences, Beijing, China"
            },
            {
                "name": "Y. S. Chen",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Er-Tao Li",
                "org": "College of Physics and Energy, Shenzhen University, Shenzhen, China"
            },
            {
                "name": "Suyalatu Zhang",
                "org": "College of Physics and Electronics Information, Inner Mongolia University for Nationalities, Tongliao, China"
            },
            {
                "name": "Shao-Lan Bi",
                "org": "Department of Astronomy, Beijing Normal University, Beijing, China"
            },
            {
                "name": "Ya-Qian Wu",
                "org": "Department of Astronomy, Beijing Normal University, Beijing, China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "B. Guo",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Qi Gao",
                "org": "Key Laboratory of Optical Astronomy, National Astronomical Observatories, Chinese Academy of Sciences, Beijing, China"
            },
            {
                "name": "Jun-Bo Zhang",
                "org": "Key Laboratory of Optical Astronomy, National Astronomical Observatories, Chinese Academy of Sciences, Beijing, China"
            },
            {
                "name": "Ze-Ming Zhou",
                "org": "Key Laboratory of Optical Astronomy, National Astronomical Observatories, Chinese Academy of Sciences, Beijing, China"
            },
            {
                "name": "Hai-Ning Li",
                "org": "Key Laboratory of Optical Astronomy, National Astronomical Observatories, Chinese Academy of Sciences, Beijing, China"
            },
            {
                "name": "Gang Zhao",
                "org": "Key Laboratory of Optical Astronomy, National Astronomical Observatories, Chinese Academy of Sciences, Beijing, China"
            }
        ],
        "venue": "Nature Astronomy",
        "year": 2018
    },
    "38NqSjGo": {
        "id": "38NqSjGo",
        "title": "Enhancement of beta+-Decay Rate of 22Na in Metal Pd at Low Temperature",
        "abstract": "",
        "keywords": [
            "room temperature",
            "decay rate"
        ],
        "authors": [
            {
                "name": "gang lian",
                "org": ""
            },
            {
                "name": "jun su",
                "org": ""
            },
            {
                "name": "baoxiang wang",
                "org": ""
            },
            {
                "name": "chao jiang",
                "org": ""
            },
            {
                "name": "xixiang bai",
                "org": ""
            },
            {
                "name": "sheng zeng",
                "org": ""
            },
            {
                "name": "yongnan zheng",
                "org": ""
            },
            {
                "name": "shengyun zhu",
                "org": ""
            },
            {
                "name": "lihua zhu",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "zhihong li",
                "org": ""
            },
            {
                "name": "youbao wang",
                "org": ""
            },
            {
                "name": "bing guo",
                "org": ""
            },
            {
                "name": "yunju li",
                "org": ""
            },
            {
                "name": "xing qin",
                "org": ""
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2008
    },
    "B6erWT2R": {
        "id": "B6erWT2R",
        "title": "Measurement of the Angular distribution for the 7 Be(d, n) 8 B reaction and determination of the astrophysical S factor for the 7 Be(p, \u03b3) 8 B reaction",
        "abstract": "",
        "keywords": [
            "cross section"
        ],
        "authors": [
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "xixiang bai",
                "org": ""
            },
            {
                "name": "shuhua zhou",
                "org": ""
            },
            {
                "name": "zhichang li",
                "org": ""
            },
            {
                "name": "youbao wang",
                "org": ""
            },
            {
                "name": "anli li",
                "org": ""
            },
            {
                "name": "zhongyu ma",
                "org": ""
            },
            {
                "name": "baoqiu chen",
                "org": ""
            },
            {
                "name": "xiaodong tang",
                "org": ""
            },
            {
                "name": "yinlu han",
                "org": ""
            },
            {
                "name": "qingbiao shen",
                "org": ""
            },
            {
                "name": "jincheng xu",
                "org": ""
            }
        ],
        "venue": "Nuclear Physics",
        "year": 1997
    },
    "2uW9UKsl": {
        "id": "2uW9UKsl",
        "title": "Single-particle resonance levels in 14O examined by 13N + p elastic resonance scattering",
        "abstract": "Single-particle properties of low-lying resonance levels in 14O have been studied efficiently by utilizing a technique of proton elastic resonance scattering with a 13N secondary beam and a thick proton target. The excitation functions for the 13N + p elastic scattering were measured over a wide energy range of ECM = 0.4 - 3.3 \u00a0 MeV and fitted with an R-matrix calculation. A clear assignment of J\u03c0 = 2- has been made for the level at Ex = 6.767 (11) \u00a0 MeV in 14O for the first time. The excitation functions show a signature of a new 0- level at Ex = 5.71 (2) \u00a0 MeV with \u0393 = 400 (100) \u00a0 keV. The excitation energies and widths of the 14O levels are discussed in conjunction with the spectroscopic structure of A = 14 nuclei with T = 1. \u00a9 2007 Elsevier B.V. All rights reserved.",
        "keywords": [
            "Elastic resonance scattering",
            "Radioactive ion beam",
            "Resonance levels",
            "Spectroscopic factors"
        ],
        "authors": [
            {
                "name": "Takashi Teranishi",
                "org": "Kyushu University(Kyushu University),Fukuoka,Japan"
            },
            {
                "name": "Shigeru Kubono",
                "org": "University of Tokyo(University of Tokyo),Tokyo,Japan"
            },
            {
                "name": "Hidetoshi Yamaguchi",
                "org": "University of Tokyo(University of Tokyo),Tokyo,Japan"
            },
            {
                "name": "Jianjun He",
                "org": "University of Tokyo(University of Tokyo),Tokyo,Japan"
            },
            {
                "name": "Akito Saito",
                "org": "University of Tokyo(University of Tokyo),Tokyo,Japan"
            },
            {
                "name": "H. Fujikawa",
                "org": "University of Tokyo(University of Tokyo),Tokyo,Japan"
            },
            {
                "name": "G. Am\u00e1dio",
                "org": "University of Tokyo(University of Tokyo),Tokyo,Japan"
            },
            {
                "name": "M. Niikura",
                "org": "University of Tokyo(University of Tokyo),Tokyo,Japan"
            },
            {
                "name": "Susumu Shimoura",
                "org": "University of Tokyo(University of Tokyo),Tokyo,Japan"
            },
            {
                "name": "Yasuo Wakabayashi",
                "org": "Kyushu University(Kyushu University),Fukuoka,Japan"
            },
            {
                "name": "Shunji Nishimura",
                "org": "Riken(RIKEN),Wako,Japan"
            },
            {
                "name": "Masahiro Nishimura",
                "org": "Riken(RIKEN),Wako,Japan"
            },
            {
                "name": "Junyoung Moon",
                "org": "Chung-Ang University(Chung-Ang University),Seoul,South Korea"
            },
            {
                "name": "Chunsik Lee",
                "org": "Chung-Ang University(Chung-Ang University),Seoul,South Korea"
            },
            {
                "name": "Atsuko Odahara",
                "org": "Nishinippon Institute of Technology(Nishinippon Institute of Technology,Nishinippon Inst of Technology),Miyako,Japan"
            },
            {
                "name": "D\u00f3ra Sohler",
                "org": "Atommagkutat\u00f3 Int\u00e9zete(Hungarian Academy of Sciences,^ the Hungarian Academy of Sciences),Debrecen,Hungary"
            },
            {
                "name": "Le Hong Khiem",
                "org": "Vietnamese Academy of Science and Technology Institute of Physics and Electronics(Institute of Physics,^ VAST),Hanoi,Viet Nam"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics",
        "year": 2007
    },
    "msa0eG7k": {
        "id": "msa0eG7k",
        "title": "Determination of the astrophysically relevant 6Li(n, \u03b3) 7Li cross sections from the 7Li( 6Li, 7Li) 6Li elastic-transfer reaction",
        "abstract": "Angular distributions for the ~7Li(~6Li,~7Li)~6Li Li elastic-transfer reaction have been measured with the Q3D magnetic spectrograph at the HI-13 tandem accelerator of Beijing, China. The neutron spectroscopic factors of 7Li are derived by comparing the calculated differential cross sections, which are obtained through the distorted-wave Born approximation (DWBA) calculation, to the experimental data. And these spectroscopic factors are then used to deduce the direct capture cross sections in 6Li(n,\u03b3)7 Li at energies of astrophysical relevance.",
        "keywords": [
            "big bang nucleosynthesis",
            "elastic-transfer reaction",
            "spectroscopic factor"
        ],
        "authors": [
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhichang Li.",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "JianCheng Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "YunJu Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Ertao Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Qiwen Fan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "\u7b49\u79bb\u5b50\u4f53\u79d1\u5b66\u4e0e\u6280\u672f(\u82f1\u6587\u7248)",
        "year": 2012
    },
    "aknA4YWQ": {
        "id": "aknA4YWQ",
        "title": "NUCLEAR PHYSICS: Angular Distribution of the 12C(6He, 7Li)11B Reaction",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ertao li",
                "org": "zhengzhou university"
            },
            {
                "name": "zhihong li",
                "org": ""
            },
            {
                "name": "yunju li",
                "org": ""
            },
            {
                "name": "shengquan yan",
                "org": ""
            },
            {
                "name": "xixiang bai",
                "org": ""
            },
            {
                "name": "bing guo",
                "org": ""
            },
            {
                "name": "jun su",
                "org": ""
            },
            {
                "name": "yobao wang",
                "org": ""
            },
            {
                "name": "baoxiang wang",
                "org": ""
            },
            {
                "name": "gang lian",
                "org": ""
            },
            {
                "name": "sheng zeng",
                "org": ""
            },
            {
                "name": "xiao fang",
                "org": ""
            },
            {
                "name": "weijuan zhao",
                "org": "zhengzhou university"
            },
            {
                "name": "weiping liu",
                "org": ""
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2009
    },
    "fTrNFbT4": {
        "id": "fTrNFbT4",
        "title": "Angular Distribution for the 7Be( d,n)8B Reaction at Ec.m.=5.8 MeV and the S17(0) Factor for the 7Be( p,\u03b3)8B Reaction",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Xixiang Bai",
                "org": ""
            },
            {
                "name": "Shuhua Zhou",
                "org": ""
            },
            {
                "name": "Zhanwen Ma",
                "org": ""
            },
            {
                "name": "Zhichang Li",
                "org": ""
            },
            {
                "name": "Youbao Wang",
                "org": ""
            },
            {
                "name": "Anli Li",
                "org": ""
            },
            {
                "name": "Zhongyu Ma",
                "org": ""
            },
            {
                "name": "Baoqiu Chen",
                "org": ""
            },
            {
                "name": "Xiaodong Tang",
                "org": ""
            },
            {
                "name": "Yinlu Han",
                "org": ""
            },
            {
                "name": "Qingbiao Shen",
                "org": ""
            }
        ],
        "venue": "Physical Review Letters",
        "year": 1996
    },
    "Czf9EY8c": {
        "id": "Czf9EY8c",
        "title": "Angular distribution of 6 He+p elastic scattering",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "gang lian",
                "org": ""
            },
            {
                "name": "shengquan yan",
                "org": ""
            },
            {
                "name": "sheng zeng",
                "org": ""
            },
            {
                "name": "jun su",
                "org": ""
            },
            {
                "name": "bing guo",
                "org": ""
            },
            {
                "name": "xixiang bai",
                "org": ""
            },
            {
                "name": "xin liu",
                "org": ""
            },
            {
                "name": "youbao wang",
                "org": ""
            },
            {
                "name": "zhihong li",
                "org": ""
            },
            {
                "name": "sunjun jin",
                "org": ""
            },
            {
                "name": "baoxiang wang",
                "org": ""
            },
            {
                "name": "yunju li",
                "org": ""
            },
            {
                "name": "ertao li",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "wuzhen huang",
                "org": ""
            }
        ],
        "venue": "Chinese Physics C",
        "year": 2012
    },
    "7cf920jJ": {
        "id": "7cf920jJ",
        "title": "Experimental study of 13N(p, \u03b3)14O reaction of astrophysical importance",
        "abstract": "13N(p, \u03b3)14O is one of the key reaction in hot CNO cycle, which is important for studying the energy source of evolution of stars. The angular distribution of 13N(d, n)14O at Ecm=8.9 MeV was measured using 13N beam produced by secondary beam facility at HI-13 tandem accelerator. The ANC of 14O was then extracted to be (29.4\u00b15.3) fm-1. In addition, we derived the asymptotic normalization coefficient (ANC) of 14O by analyzing the 13C(d, p)14C angular distribution based on charge symmetry of mirror nuclei, which agrees with the experimental result. The astrophysical S factor and reaction rate of 13N(p, \u03b3)14O were then calculated using R-matrix theory and were inputted into astrophysical reaction network. It shows the energy generated by CNO cycle in novae using the present data is 5% more than that using the previous ones, which could affect the evolution of novae.",
        "keywords": [
            "Angular distribution",
            "Astrophysical S factor",
            "Asymptotic normalization coefficient",
            "Hot CNO cycle",
            "Radioactive nuclear beam"
        ],
        "authors": [
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "LI Zhi-hong",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "YAN Sheng-quan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "BAI Xi-xiang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "WANG You-bao",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "WANG Bao-xiang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "SHU Neng-chuan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "CHEN Yong-shou",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "CHANG Hong-wei",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "JIANG Li-yang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Yuanzineng Kexue Jishu/Atomic Energy Science and Technology",
        "year": 2009
    },
    "8tUKFET4": {
        "id": "8tUKFET4",
        "title": "Calculation of astrophysical reaction rate of ~(82)Ge(n,\u03b3)~(83)Ge",
        "abstract": "The neutron capture reaction on a neutron-rich near closed-shell nucleus 82Ge may play an important role in the r-process following the fallout from nuclear statistical equilibrium in core-collapse supernovae. By carrying out a DWBA analysis for the experimental angular distribution of 82Ge(d, p)83Ge reaction we obtain the single particle spectroscopic factors, S2,5/2 and S0,1/2 for the ground and first excited states of 83Ge=82Ge\ue3c1n, respectively. And then these spectroscopic factors are used to calculate the direct capture cross sections for the 82Ge(n, \u03b3)83Ge reaction at energies of astrophysical interest. The optical potential for neutron scattering on unstable nucleus 82Ge is not known experimentally. We employed a real folding potential which was calculated by using the proper 82Ge density distribution and an effective nucleon-nucleon force DDM3Y. The neutron capture reactions on neutron-rich closed-shell nuclei are expected to be dominated by the direct capture to bound states. We will show that the direct capture rates on these nuclei are sensitive to the structure of the low-lying states.",
        "keywords": [
            "astrophysical reaction rate",
            "neutron capture",
            "spectroscopic factor"
        ],
        "authors": [
            {
                "name": "WANG Mian",
                "org": "China Institute of Atomic Energy, Beijing , China"
            },
            {
                "name": "CHEN Yong-Shou",
                "org": "China Institute of Atomic Energy, Beijing , China"
            },
            {
                "name": "LI Zhi-Hong",
                "org": "China Institute of Atomic Energy, Beijing , China"
            },
            {
                "name": "LIU Wei-Ping",
                "org": "China Institute of Atomic Energy, Beijing , China"
            },
            {
                "name": "SHU Neng-Chuan",
                "org": "China Institute of Atomic Energy, Beijing , China"
            }
        ],
        "venue": "Chinese Physics C",
        "year": 2009
    },
    "OAAAx09r": {
        "id": "OAAAx09r",
        "title": "Angular distribution for 2H(6He, 7Li)n reaction and proton spectroscopic factor of 7Li",
        "abstract": "The angular distribution of the 2H(6He, 7Li)n reaction was measured at Ecm=9.1 MeV for the first time using the secondary beam facility of HI-13 tandem accelerator. The experimental data were analyzed with distorted wave Born approximation (DWBA) calculation and the proton spectroscopic factor of 7Li was extracted to be 0.40\u00b10.02.",
        "keywords": [
            "6He secondary beam",
            "Angular distribution",
            "Distorted wave Born approximation",
            "Spectroscopic factor"
        ],
        "authors": [
            {
                "name": "LI Er-tao",
                "org": "Zhengzhou University(Zhengzhou University),Zhengzhou,China"
            },
            {
                "name": "LI Zhi-hong",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "LI Yun-ju",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "YAN Sheng-quan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "WANG You-bao",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "WANG Bao-xiang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "BAI Xi-xiang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xiao Fang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "ZHAO Wei-juan",
                "org": "Zhengzhou University(Zhengzhou University),Zhengzhou,China"
            }
        ],
        "venue": "Yuanzineng Kexue Jishu/Atomic Energy Science and Technology",
        "year": 2010
    },
    "aNo1e59G": {
        "id": "aNo1e59G",
        "title": "Measurement of angular distribution for 11C(d,n)12N reaction and determination of asymptotic normalization coefficient for the virtual decay 12N\u219211C + p",
        "abstract": "Angular distribution of the 11C(d,n)12N reaction at Ec.m. = 9.8 MeV was measured in inverse kinematics with the secondary 11C beam. The peripheral of this reaction was also verified by changing the radial parameter limit in distorted wave Born approximation (DWBA) calculations. The experimental data were analyzed with DWBA calculations and thereby the square of asymptotic normalization coefficient (ANC) was extracted to be (2.86 \u00b1 0.91) fm-1 for the virtual decay 12N\u219211C + p. The present work shows that the direct capture contribution in the 11C(p,\u03b3)12N reaction is of importance.",
        "keywords": [
            "2H(11C",
            "12N)n reaction in inverse kinematics",
            "Angular distribution",
            "Asymptotic normalization coefficient method",
            "Distorted-wave Born approximation"
        ],
        "authors": [
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yongshou Chen",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yun Lu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Kaisu Wu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Nengchuan Shu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhongdao Lu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Yuanzineng Kexue Jishu/Atomic Energy Science and Technology",
        "year": 2005
    },
    "9UnGk4UB": {
        "id": "9UnGk4UB",
        "title": "Current progress of nuclear astrophysics study and BRNBF at CIAE",
        "abstract": "A secondary beam line (GIRAFFE) at the Beijing tandem accelerator lab was constructed for yielding low energy secondary beams. The current progress on the study of nuclear astrophysics and nuclear structure is presented. Up to now, we have carried out measurement of 7 Be(d,n) 8 B, 11 C(d,n) 12 N, 8 Li(d,n) 9 Be and 6 He(p,n) 6 Li reactions. The proposed Beijing radioactive nuclear beam facility and its current R&D progress are briefly introduced. This facility is based on the exist HI-13 tandem accelerator. A proton cyclotron will be built to provide 100 MeV 200 \u03bcA proton beam, together with an isotope separator on line system and a super-conducting heavy ion LINAC. By this facility, intensity of order of 10 9 pps radioactive nuclear beams for mass up to A =120 will be produced.",
        "keywords": [
            "25.60.\u2212t",
            "nuclear astrophysical reaction",
            "26.20.+f",
            "radioactive nuclear beam facility",
            "secondary beam line",
            "25.45.hi",
            "26.65.+t",
            "nuclear astrophysics",
            "nuclear structure"
        ],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy (CIAE), P.O. Box 275(80), Beijing 102413, People\u2019s Republic of China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy (CIAE), P.O. Box 275(80), Beijing 102413, People\u2019s Republic of China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy (CIAE), P.O. Box 275(80), Beijing 102413, People\u2019s Republic of China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy (CIAE), P.O. Box 275(80), Beijing 102413, People\u2019s Republic of China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy (CIAE), P.O. Box 275(80), Beijing 102413, People\u2019s Republic of China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy (CIAE), P.O. Box 275(80), Beijing 102413, People\u2019s Republic of China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy (CIAE), P.O. Box 275(80), Beijing 102413, People\u2019s Republic of China"
            },
            {
                "name": "Zhixiang Zhao",
                "org": "China Institute of Atomic Energy (CIAE), P.O. Box 275(80), Beijing 102413, People\u2019s Republic of China"
            },
            {
                "name": "Tianjue Zhang",
                "org": "China Institute of Atomic Energy (CIAE), P.O. Box 275(80), Beijing 102413, People\u2019s Republic of China"
            },
            {
                "name": "Hongqing Tang",
                "org": "China Institute of Atomic Energy (CIAE), P.O. Box 275(80), Beijing 102413, People\u2019s Republic of China"
            },
            {
                "name": "Bingfan Yang",
                "org": "China Institute of Atomic Energy (CIAE), P.O. Box 275(80), Beijing 102413, People\u2019s Republic of China"
            },
            {
                "name": "Xialing Guan",
                "org": "China Institute of Atomic Energy (CIAE), P.O. Box 275(80), Beijing 102413, People\u2019s Republic of China"
            },
            {
                "name": "Baoqun Cui",
                "org": "China Institute of Atomic Energy (CIAE), P.O. Box 275(80), Beijing 102413, People\u2019s Republic of China"
            }
        ],
        "venue": "Nuclear Inst. and Methods in Physics Research, B",
        "year": 2003
    },
    "o8SJyqYO": {
        "id": "o8SJyqYO",
        "title": "Excited states in 18Ne studied via 17F + p",
        "abstract": "The elastic resonance scattering of 17F+p is studied in inverse kinematics via a thick-target method. The excitation function for 17F+p elastic scattering is obtained within the energy interval of Ec.m. \u223c 0.4-1.7 MeV. The experimental excitation function is analyzed with a multilevel R-matrix code MULTI7, and the proton widths are deduced. The \u03b1 decay from 6.15 MeV 1- state in 18Ne is observed, which is critical to the 14O(\u03b1, p)17 F reaction as the main breakout route from CNO cycle to rp-process in supernovae and x-ray bursts. \u00a9 2010 Chinese Physical Society and IOP Publishing Ltd.",
        "keywords": [
            "elastic scattering",
            "excited states",
            "inverse kinematics"
        ],
        "authors": [
            {
                "name": "SunJun Jin",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xiao Fang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Ertao Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "YunJu Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zeen Yao",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2010
    },
    "fKD6xSwT": {
        "id": "fKD6xSwT",
        "title": "Parametrization of woods-saxon potential for heavy-ion systems",
        "abstract": "Several elastic scattering angular distributions of 12C from target nuclei of A \u2265 39 are analyzed to extract theWoods-Saxon potential parameters with the fixed imaginary potential and Coulomb radius parameters. Using the best fitted diffuseness parameters, the correlations of the real part parameters with A  1 1/3  + A 2 1/3  and incident energy are revealed, and the systematic Woods-Saxon potential parameters are presented for nucleus-nucleus interaction. The proposed potential parameters can reproduce not only the elastic scattering angular distributions induced by 12C, but also many elastic scattering angular distributions induced by the projectiles other than 12C, thus providing important inputs for the study of nuclear reactions of heavy-ion systems.",
        "keywords": [
            "optical potential",
            " elastic scattering",
            " heavy-ion reactions",
            " 24.10.Ht",
            " 25.70.Bc",
            " 25.75.-q"
        ],
        "authors": [
            {
                "name": "L. Gan",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "H. B. Sun",
                "org": "College of Physics and Energy, Shenzhen University, Shenzhen, China"
            },
            {
                "name": "D. Y. Pang",
                "org": "School of Physics and Nuclear Energy Engineering, Beihang University, Beijing, China"
            },
            {
                "name": "B. Guo",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Y. J. Li",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Er-Tao Li",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "G. Lian",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "ZhiYu Han",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "XinYue Li",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "DongHui Li",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "TianLi Ma",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "ChangJin Pei",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Y. P. Shen",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Yi Su",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "S. Zeng",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Yong Zhou",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy, Beijing, China"
            }
        ],
        "venue": "Science China-physics Mechanics & Astronomy",
        "year": 2017
    },
    "92zRbzuN": {
        "id": "92zRbzuN",
        "title": "The 33S(p,\u03b3)34Cl reaction in classical nova explosions",
        "abstract": "The analysis of microscopic grains within primitive meteorites has revealed isotopic ratios largely characteristic of the conditions thought to prevail in various astrophysical environments. Recently, several grains have been identified with isotopic signatures similar to those predicted within the ejecta of nova explosions on oxygen-neon white dwarfs. A possible smoking gun for a grain of nova origin is a large 33S abundance: nucleosynthesis calculations predict as much as 150 times the solar abundance of 33S in the ejecta of oxygen-neon novae. This overproduction factor may, however, vary by factors of at least 0.01 - 3 because of uncertainties in the 33S(p,\u03b3)34Cl reaction rate over nova temperatures. In addition, better knowledge of this rate would help with the interpretation of nova observations over the S-Ca mass region, and contribute towards the firm establishment of a nucleosynthetic endpoint in these phenomena. Finally, constraining this rate may help to finally confirm or rule out the decay of an isomeric state of 34Cl (Ex = 146 keV, t1/2 =32 min) as a source for observable gamma-rays from novae. Direct examinations of the 33S(p,\u03b3)34Cl reaction in the past have only identified resonances down to Er = 434 keV. At nova temperatures, lower-lying resonances could certainly play a dominant role. Several recent, complementary studies dedicated to improving our knowledge of the 33S(p,\u03b3)34Cl rate, using both indirect methods (measurement of the 34S( 3He,t)34Cl and 33S(3He,d) 34Cl reactions with the Munich Q3D spectrograph) and direct methods (in normal kinematics at CENPA, University of Washington, and in inverse kinematics with the DRAGON recoil mass separator at TRIUMF) are presented here. Our results affect predictions of sulphur isotopic ratios in nova ejecta (e.g. 32S/33S) that may be used as diagnostic tools for the nova paternity of grains. \u00a9 ?Copyright owned by the author(s).",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Anuj R. Parikh",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Th Faestermann",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Reiner Kr\u00fcken",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Vinzenz Bildstein",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Shawn M. Bishop",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Katrin Eppinger",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Clemens Herlitzius",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Olga A. Lepyoshkina",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Peter Maierbeck",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Dominik Seiler",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Kathrin Wimmer",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Ralf Hertenberger",
                "org": "Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen(University of Munich),M\u00fcnchen,Germany"
            },
            {
                "name": "Hans Friedrich Wirth",
                "org": "Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen(University of Munich),M\u00fcnchen,Germany"
            },
            {
                "name": "Jennifer Fallis",
                "org": "TRIUMF(TRIUMF),Vancouver,Canada"
            },
            {
                "name": "Ulrike Hager",
                "org": "TRIUMF(TRIUMF),Vancouver,Canada"
            },
            {
                "name": "Dave A. Hutcheon",
                "org": "TRIUMF(TRIUMF),Vancouver,Canada"
            },
            {
                "name": "Chris Ruiz",
                "org": "TRIUMF(TRIUMF),Vancouver,Canada"
            },
            {
                "name": "Lothar R. Buchmann",
                "org": "TRIUMF(TRIUMF),Vancouver,Canada"
            },
            {
                "name": "Dave F. Ottewell",
                "org": "TRIUMF(TRIUMF),Vancouver,Canada"
            },
            {
                "name": "Blake M. Freeman",
                "org": "University of Washington Seattle(Univ. Washington,University of Washington),Seattle,United States"
            },
            {
                "name": "Chris Wrede",
                "org": "University of Washington Seattle(Univ. Washington,University of Washington),Seattle,United States"
            },
            {
                "name": "Alejandro R. Garc\u00eda",
                "org": "University of Washington Seattle(Univ. Washington,University of Washington),Seattle,United States"
            },
            {
                "name": "Brent G. Delbridge",
                "org": "University of Washington Seattle(Univ. Washington,University of Washington),Seattle,United States"
            },
            {
                "name": "Andreas Knecht",
                "org": "University of Washington Seattle(Univ. Washington,University of Washington),Seattle,United States"
            },
            {
                "name": "Anne L. Sallaska",
                "org": "University of Washington Seattle(Univ. Washington,University of Washington),Seattle,United States"
            },
            {
                "name": "Alan Chen",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Jason A. Clark",
                "org": "Argonne National Laboratory(Argonne National Laboratory,Argonne Natl Lab),Argonne,United States"
            },
            {
                "name": "Catherine M. Deibel",
                "org": "Argonne National Laboratory(Argonne National Laboratory,Argonne Natl Lab),Argonne,United States"
            },
            {
                "name": "Brian R. Fulton",
                "org": "University of York(University of York),York,United Kingdom"
            },
            {
                "name": "Alison M. Laird",
                "org": "University of York(University of York),York,United Kingdom"
            },
            {
                "name": "Uwe Greife",
                "org": "Colorado School of Mines(Colorado School of Mines,Colorado Sch of Mines),Golden,United States"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Ertao Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Peter D. Parker",
                "org": "Yale University(Yale University),New Haven,United States"
            },
            {
                "name": "Kiana Setoodehnia",
                "org": "McMaster University(McMaster University),Hamilton,Canada"
            }
        ],
        "venue": "Proceedings of Science",
        "year": 2010
    },
    "FAOgn1ne": {
        "id": "FAOgn1ne",
        "title": "New determination of the 7Be ground state spectroscopic factor and the 6Li(p, ${\\rm{\\gamma }}$)7 Be astrophysical ${S}({E})$ factors",
        "abstract": "The u0027lithium problemu0027 in Big Bang nucleosynthesis (BBN) has recently focused on reactions involving 7Be. The 6Li()7Be reaction can provide us not only with information about 6Li destruction but also with information about 7Be production. In the present work, the proton spectroscopic factor in 7Be is extracted to be 0.70 \u00b1 0.17 from the angular distribution of 7Be(d, 3He)6Li at . This value is then used to compute the direct component of the astrophysical 6Li()7Beg.s. S(E) factors and determine the resonance parameters from the total S(E) factors.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy, Beijing 102413, China"
            },
            {
                "name": "Er-Tao Li",
                "org": "College of Physics and Energy, Shenzhen University, Shenzhen 518060, China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy, Beijing 102413, China"
            },
            {
                "name": "Y. J. Li",
                "org": "China Institute of Atomic Energy, Beijing 102413, China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy, Beijing 102413, China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy, Beijing 102413, China"
            },
            {
                "name": "B. Guo",
                "org": "China Institute of Atomic Energy, Beijing 102413, China"
            },
            {
                "name": "Ding Nan",
                "org": "China Institute of Atomic Energy, Beijing 102413, China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy, Beijing 102413, China"
            }
        ],
        "venue": "Chinese Physics C",
        "year": 2018
    },
    "tlAjKWfZ": {
        "id": "tlAjKWfZ",
        "title": "Current progress of nuclear astrophysical reaction and decay study at CIAE",
        "abstract": "Presented here was current progress of the study of nuclear astrophysical reaction and decay at CIAE. We studied astrophysical 12N(p,\u03b3) 13O reaction through the measurement of the 12N(d,n) 13O angular distribution in inverse kinematics. Our result is in agreement with that from the 14N(12N,13O) 13C reaction and two shell model calculations. We also measured the angular distributions of single neutron transfer reaction of 7Li(6Li,7Li)6Li, and derived the reaction cross section for 6Li(n,\u03b3)7Li by using the present spectroscopic factor. The astrophysical reaction rate is found to be higher by a factor of 1.7 than the value adopted in previous reaction network calculations. In addition, half-life of 147Sm in metal samarium and Sm2O3 was measured. No significant change has been observed within the experimental uncertainty.",
        "keywords": [
            "reaction rate",
            "cross section",
            "nuclear astrophysics",
            "inverse kinematics"
        ],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "YunJu Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Ertao Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "SunJun Jin",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xin Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Journal of Physics: Conference Series",
        "year": 2011
    },
    "de30ZnI0": {
        "id": "de30ZnI0",
        "title": "Calculation of astrophysical reaction rate of 82Ge(n,gamma)83Ge",
        "abstract": "",
        "keywords": [
            "neutron scattering",
            "bound states",
            "reaction rate",
            "cross section",
            "excited states"
        ],
        "authors": [
            {
                "name": "mian wang",
                "org": ""
            },
            {
                "name": "yongshou chen",
                "org": ""
            },
            {
                "name": "zhihong li",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "nengchuan shu",
                "org": ""
            }
        ],
        "venue": "Chinese Physics C",
        "year": 2009
    },
    "Bb5jNxqu": {
        "id": "Bb5jNxqu",
        "title": "New Measurement of Proton Transfer Reactions and Elastic Scattering for 7 Li + 13 C at 34 MeV",
        "abstract": "",
        "keywords": [
            "excited states",
            "phase shift",
            "elastic scattering"
        ],
        "authors": [
            {
                "name": "yunju li",
                "org": ""
            },
            {
                "name": "zhihong li",
                "org": ""
            },
            {
                "name": "bing guo",
                "org": ""
            },
            {
                "name": "jun su",
                "org": ""
            },
            {
                "name": "xixiang bai",
                "org": ""
            },
            {
                "name": "ertao li",
                "org": ""
            },
            {
                "name": "baoxiang wang",
                "org": ""
            },
            {
                "name": "shengquan yan",
                "org": ""
            },
            {
                "name": "sheng zeng",
                "org": ""
            },
            {
                "name": "jiancheng liu",
                "org": ""
            },
            {
                "name": "xin liu",
                "org": ""
            },
            {
                "name": "sunjun jin",
                "org": ""
            },
            {
                "name": "q fan",
                "org": ""
            },
            {
                "name": "gang lian",
                "org": ""
            },
            {
                "name": "youbao wang",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            }
        ],
        "venue": "Plasma Science & Technology",
        "year": 2012
    },
    "kN2dEmaA": {
        "id": "kN2dEmaA",
        "title": "Determination of 11C(p,gamma)12N astrophysical S-factor via measurement of 11C(d,n)12N reaction",
        "abstract": "",
        "keywords": [
            "excited states",
            "reaction rate",
            "inverse kinematics",
            "ground state",
            "reaction mechanism"
        ],
        "authors": [
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "zhihong li",
                "org": ""
            },
            {
                "name": "xixiang bai",
                "org": ""
            },
            {
                "name": "bing guo",
                "org": ""
            },
            {
                "name": "sheng zeng",
                "org": ""
            },
            {
                "name": "yongshou chen",
                "org": ""
            },
            {
                "name": "shengquan yan",
                "org": ""
            },
            {
                "name": "baoxiang wang",
                "org": ""
            },
            {
                "name": "gang lian",
                "org": ""
            },
            {
                "name": "yun guang lu",
                "org": ""
            },
            {
                "name": "kaisu wu",
                "org": ""
            },
            {
                "name": "nengchuan shu",
                "org": ""
            }
        ],
        "venue": "Nuclear Physics",
        "year": 2003
    },
    "QOzXudg0": {
        "id": "QOzXudg0",
        "title": "Neutron spectroscopic factors of 7Li and astrophysical 6Li(n,\u03b3)7Li reaction rates",
        "abstract": "Angular distributions of the 7Li(6Li, 6Li)7Li elastic scattering and the 7Li( 6Li, 7Lig.s.)6Li, 7Li(6Li, 7Li0.48)6Li transfer reactions at Ec.m. 23.7 MeV are measured with the Q3D magnetic spectrograph. The optical potential of 6Li + 7Li is obtained by fitting the elastic scattering differential cross sections. Based on the distorted wave Born approximation (DWBA) analysis, spectroscopic factors of 7Li 6Li \u2297 n are determined to be 0.73 0.05 and 0.90 0.09 for the ground and first exited states in 7Li, respectively. Using the spectroscopic factors, the cross sections of the 6Li(n, \u03b30, 1)7Li direct neutron capture reactions and the astrophysical 6Li(n, \u03b3)7Li reaction rates are derived. \u00a9 2010 Chinese Physical Society and IOP Publishing Ltd.",
        "keywords": [],
        "authors": [
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhichang Li.",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "JianCheng Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "YunJu Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Ertao Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Qiwen Fan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2010
    },
    "cCnuUtCK": {
        "id": "cCnuUtCK",
        "title": "Empirical formula for <Emphasis Type=\"Italic\">\u03b2</Emphasis><Superscript>\u2212</Superscript>-decay half-lives of r-process nuclei",
        "abstract": "Experimental data of \u03b2 \u2212-decay half-lives of nuclei with atomic number between 20 and 190 are investigated. A systematic formula has been proposed to calculate \u03b2 \u2212-decay half-lives of neutron-rich nuclei, with a particular consideration on shell and pair effects, the decay energy Q as well as the nucleon numbers (Z, N). Although the formula has relatively few parameters, it reproduces the experimental \u2014decay half-lives of neutron-rich nuclei very well. The predicted half-lives for the r-process relevant nuclei obtained with the current formula serve as reliable input in the r-process model calculations.",
        "keywords": [
            "\u00df--decay half-lives",
            " neutron-rich nuclei",
            " r-process"
        ],
        "authors": [
            {
                "name": "Yong\u00a0Zhou",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "ZhiHong\u00a0Li",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "YouBao\u00a0Wang",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "YongShou\u00a0Chen",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "Bing\u00a0Guo",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "Jun\u00a0Su",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "YunJu\u00a0Li",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "ShengQuan\u00a0Yan",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "XinYue\u00a0Li",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "ZhiYu\u00a0Han",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "YangPing\u00a0Shen",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "Lin\u00a0Gan",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "Sheng\u00a0Zeng",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "Gang\u00a0Lian",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "WeiPing\u00a0Liu",
                "org": "China Institute of Atomic Energy,Beijing,China"
            }
        ],
        "venue": "Science China Physics, Mechanics & Astronomy",
        "year": 2017
    },
    "x3zQEQD4": {
        "id": "x3zQEQD4",
        "title": "Determination of the astrophysical 8Li(n, \u03b3)9Li reaction rate from the measurement of 2H(8Li,9 Li)1H reaction",
        "abstract": "The cross section of the 8Li(n, \u03b3)9Li reaction has attracted much attention for many years because of its importance in nuclear astrophysics. The single particle spectroscopic factor, S1,3/2 for the ground state of 9Li = 8Li \u2297 n derived from the transfer reaction of 8Li(d, p)9Li was used to calculate the direct radiative capture reaction rates of 8Li(n, \u03b3) 9Li at energies of astrophysical interest. The present result shows that the 8Li(n, \u03b3)9Li direct capture reaction may play an important role in the astrophysical environments of inhomogeneous big bang and type II supernovae. \u00a9 2006 American Institute of Physics.",
        "keywords": [
            "nucleosynthesis",
            "radiative capture",
            "spectroscopic factor",
            "transfer reaction",
            "big bang nucleosynthesis",
            "ground state",
            "nuclear astrophysics",
            "reaction rate",
            "big bang",
            "cross section"
        ],
        "authors": [
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yun Lu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yongshou Chen",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Kaisu Wu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Nengchuan Shu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Toshitaka Kajino",
                "org": "National Astronomical Observatory of Japan(National Astronomical Observatory,National Astronomical Observatory of Japan,Natl. Astron. Observatory of Japan),Mitaka,Japan"
            }
        ],
        "venue": "AIP Conference Proceedings",
        "year": 2006
    },
    "M25LyZsz": {
        "id": "M25LyZsz",
        "title": "Determination of the Astrophysically Relevant 6 Li(n, \u03b3) 7 Li Cross Sections from the 7 Li( 6 Li, 7 Li) 6 Li Elastic-Transfer Reaction",
        "abstract": "",
        "keywords": [
            "cross section"
        ],
        "authors": [
            {
                "name": "jun su",
                "org": ""
            },
            {
                "name": "bing guo",
                "org": ""
            },
            {
                "name": "xixiang bai",
                "org": ""
            },
            {
                "name": "zhichang li",
                "org": ""
            },
            {
                "name": "jiancheng liu",
                "org": ""
            },
            {
                "name": "youbao wang",
                "org": ""
            },
            {
                "name": "gang lian",
                "org": ""
            },
            {
                "name": "sheng zeng",
                "org": ""
            },
            {
                "name": "baoxiang wang",
                "org": ""
            },
            {
                "name": "shengquan yan",
                "org": ""
            },
            {
                "name": "yunju li",
                "org": ""
            },
            {
                "name": "ertao li",
                "org": ""
            },
            {
                "name": "q fan",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            }
        ],
        "venue": "Plasma Science & Technology",
        "year": 2012
    },
    "Qv9AdsJz": {
        "id": "Qv9AdsJz",
        "title": "Study of the primordial Lithium Abundances at CIAE",
        "abstract": "Lithium isotopes have attracted an intense interest because the predicted abundances of both 6Li and 7Li from big bang nucleosynthesis (BBN) do not match experimental observations. Many investigations of astrophysical observations and BBN calculations have been carried out in order to solve the puzzles. Several nuclear reactions involving lithium have been determined at HI-13 tandem accelerator, Beijing, China. The BBN model calculations are then performed to investigate the primordial lithium abundance. The result shows that these nuclear reactions have minimal effect on the primordial abundances of 6Li and 7Li. \u00a9 Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike Licence.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Ertao Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Y. J. Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yongshou Chen",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Suqing Hou",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xin Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "S. J. Jin",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Proceedings of Science",
        "year": 2012
    },
    "LnZn7aGj": {
        "id": "LnZn7aGj",
        "title": "How were the heavy chemical elements beyond iron made in the Universe",
        "abstract": "Nuclear astrophysics, which is an interdisciplinary branch of nuclear physics (micro scale) and astrophysics (macro scale), addresses some of the most compelling questions in the universe. Research efforts have been devoted to many topics such as the origins of the chemical elements, the unique conditions of earth that makes life possible, and the formation and evolution of the sun, stars, and galaxies. Nuclear processes play an extremely important role in cosmic evolution after the Big Bang, and they are the only known mechanisms that synthesize heavy elements, in addition to providing the energy for stars to resist the force of gravity.   Over the past  50\u2005years,  scientists have developed a deep understanding of Big-Bang primordial nucleosynthesis and the mechanisms for synthesizing heavy elements. However, the astrophysical models have yet to adequately reproduce the observed solar abundances of those elements beyond iron (referred to as ultra-iron elements). It is widely believed that these ultra-iron elements were primarily synthesized via the slow neutron capture process (s-process) and the fast neutron capture process (r-process). The fundamental s-process component is thought to originate from thermally pulsing low-mass AGB stars, with reaction pathways closed after the stable nuclides. About half of the heavy elements (up to bismuth) were produced via the s-process. The r-process is thought to occur in the explosive burning of core-collapse supernova and/or neutron-star mergers. Although the r-process site remains a mystery, experts believe that more than half of the ultra-iron elements (up to thorium and uranium) were produced via the r-process. In addition, there are 35 neutron-deficient stable isotopes, which are present in significantly less abundance in our solar system. These so-called p-nuclei are likely produced in Type II supernova, through the photo-dissociation (referred to as p-process or r-process) of existing s- or r-process seeds, or through the recently proposed neutrino-proton  v p-process.  Astrophysical models require a huge amount of nuclear-physics input data. The most essential data include nuclear mass, structure, decay and fission characteristics, and related nuclide cross-sections along the various nucleosynthesis paths. Thus far, the lack of systematic and precise nuclear inputs is one of the main reasons scientists have not been able to reproduce the observed solar abundances of ultra-iron elements. Published by  Discover  magazine in 2002, the American National Research Council ranked the question, how were the heavy elements from iron to uranium made? as one of  the 11 Greatest Unanswered Questions of Physics in this Century . More complete and precise nuclear physics inputs are therefore urgently needed to improve astrophysical models and decode the observations.  This paper introduces the most important nucleosynthesis processes that are responsible for the ultra-iron elements production in the universe, while also summarizing the relevant key nuclear-physics inputs required in the astrophysical models. Finally, the frontier in this field study includes the origins of ultra-iron elements, and the future of nuclear astrophysics research in China is examined.",
        "keywords": "",
        "authors": [
            {
                "name": "He Jianjun",
                "org": ""
            },
            {
                "name": "Guo Bing",
                "org": ""
            },
            {
                "name": "Liu Wei-Ping",
                "org": ""
            },
            {
                "name": "Zhao Gang",
                "org": ""
            }
        ],
        "venue": "Chinese Science Bulletin",
        "year": 2018
    },
    "qvWHuV9L": {
        "id": "qvWHuV9L",
        "title": "Astrophysical Rates for the 6 He( p , \u03b3) 7 Li Reaction",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jun su",
                "org": ""
            },
            {
                "name": "gang lian",
                "org": ""
            },
            {
                "name": "baoxiang wang",
                "org": ""
            },
            {
                "name": "bing guo",
                "org": ""
            },
            {
                "name": "yunju li",
                "org": ""
            },
            {
                "name": "zhihong li",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "ertao li",
                "org": ""
            },
            {
                "name": "xixiang bai",
                "org": ""
            },
            {
                "name": "youbao wang",
                "org": ""
            },
            {
                "name": "shengquan yan",
                "org": ""
            },
            {
                "name": "weijuan zhao",
                "org": ""
            },
            {
                "name": "xiao fang",
                "org": ""
            },
            {
                "name": "sheng zeng",
                "org": ""
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2011
    },
    "9mgIz0mZ": {
        "id": "9mgIz0mZ",
        "title": "Analyses of d-6,7 Li and d-7,9Be reactions",
        "abstract": "Aiming at the production of 6He, 8Li and 7Be radioactive beams, various nuclear data of d+ 6,7Li and d+9Be reactions at incident energies spanning 0.1-30.0 MeV were obtained by calculation with the distorted wave Born approximation, preequilibrium nuclear reaction and Hauser-Feshbach (HF) theory. The cross sections of d+ 7Be reaction were also predicted. The results show that the experimental measurement for d+7Be reaction is feasible at HI-13 tandem accelerator.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Yinlu Han",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Qingbiao She",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "JingShang Zhang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhengjun Zhang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xiuquan Sun",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Chinese journal of nuclear physics",
        "year": 1997
    },
    "jUOpsqpY": {
        "id": "jUOpsqpY",
        "title": "Current progress of nuclear astrophysics experiments at CIAE",
        "abstract": "This paper described current progress of nuclear astrophysical studies using the unstable ion beam facility GIRAFFE. We measured the angular distributions for some low energy reactions, such as 11C(d,n) 12N, 8Li(d,p)9Li and 17F(d,n) 18Ne in inverse kinematics, and indirectly derived the astrophysical S-factors or reaction rates of 11C(p,\u03b3)12N, 8Li(n,\u03b3)9Li, 8B(p,\u03b3)9C at astrophysically relevant energies. \u00a9 2006 American Institute of Physics.",
        "keywords": [
            "anc",
            "dwba",
            "reaction rate",
            "s-factor",
            "secondary beam facility",
            "ion beam",
            "nuclear astrophysics",
            "inverse kinematics"
        ],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Nengchuan Shu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yongshou Chen",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "AIP Conference Proceedings",
        "year": 2006
    },
    "QKK1KIPN": {
        "id": "QKK1KIPN",
        "title": "New Determination of the 13C(?, n)16O Reaction Rate and its Influence on the s-process Nucleosynthesis in AGB Stars",
        "abstract": "",
        "keywords": [
            "stars"
        ],
        "authors": [
            {
                "name": "baining guo",
                "org": ""
            },
            {
                "name": "z h li",
                "org": ""
            },
            {
                "name": "maria lugaro",
                "org": "monash university clayton campus"
            },
            {
                "name": "j buntain",
                "org": "monash university clayton campus"
            },
            {
                "name": "d y pang",
                "org": "peking university"
            },
            {
                "name": "y j li",
                "org": ""
            },
            {
                "name": "jianzhong su",
                "org": ""
            },
            {
                "name": "s q yan",
                "org": ""
            },
            {
                "name": "x x bai",
                "org": ""
            },
            {
                "name": "y s chen",
                "org": ""
            },
            {
                "name": "q w fan",
                "org": ""
            },
            {
                "name": "s j jin",
                "org": ""
            },
            {
                "name": "amanda i karakas",
                "org": ""
            },
            {
                "name": "e t li",
                "org": ""
            },
            {
                "name": "g lian",
                "org": ""
            },
            {
                "name": "j c liu",
                "org": ""
            },
            {
                "name": "xinguo liu",
                "org": ""
            },
            {
                "name": "j r shi",
                "org": "chinese academy of sciences"
            },
            {
                "name": "n c shu",
                "org": ""
            },
            {
                "name": "b x wang",
                "org": ""
            },
            {
                "name": "y b wang",
                "org": ""
            },
            {
                "name": "sheng zeng",
                "org": ""
            },
            {
                "name": "w p liu",
                "org": ""
            }
        ],
        "venue": "The Astrophysical Journal",
        "year": 2012
    },
    "stN6snhc": {
        "id": "stN6snhc",
        "title": "Experimental design of 6He(p, \u03b3)7Li reaction and beam preparation",
        "abstract": "The 6He secondary beams with the energy of 26, 32 and 38 MeV were produced via the 2H (7Li, 6He) 3He reaction on the secondary beam facility at the HI-13 tandem accelerator, Beijing. The intensity of the collimated 6He beam with a purity of 99% is about 900 s-1. The angular distribution of 2H (6He, 7Li) n reaction can be measured using this secondary 6He beam in inverse kinematics, and the astrophysical S-factor and rate of the 6He(p, \u03b3)7Li reaction can be derived.",
        "keywords": [
            "Magnetic rigidity",
            "Nuclear astrophysics",
            "Secondary beam",
            "Wien filter"
        ],
        "authors": [
            {
                "name": "LI Yun-ju",
                "org": "Zhengzhou University(Zhengzhou University),Zhengzhou,China"
            },
            {
                "name": "LI Zhi-hong",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "BAI Xi-xiang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "WANG Bao-xiang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "WANG You-bao",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xing Qin",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Chao Jiang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "ZHAO Wei-juan",
                "org": "Zhengzhou University(Zhengzhou University),Zhengzhou,China"
            }
        ],
        "venue": "Yuanzineng Kexue Jishu/Atomic Energy Science and Technology",
        "year": 2008
    },
    "93Xm0G3S": {
        "id": "93Xm0G3S",
        "title": "Study of the primordial lithium abundance",
        "abstract": "Lithium isotopes have attracted an intense interest because the abundance of both 6Li and 7Li from big bang nucleosynthesis (BBN) is one of the puzzles in nuclear astrophysics. Many investigations of both astrophysical\n observation and nucleosynthesis calculation have been carried out to solve the puzzle, but it is not solved yet. Several nuclear\n reactions involving lithium have been indirectly measured at China Institute of Atomic Energy, Beijing. The Standard BBN (SBBN)\n network calculations are then performed to investigate the primordial Lithium abundance. The result shows that these nuclear\n reactions have minimal effect on the SBBN abundances of 6Li and 7Li.",
        "keywords": [
            "nuclear astrophysics",
            "big bang nucleosynthesis",
            "nuclear reactions"
        ],
        "authors": [
            {
                "name": "ZhiHong Li",
                "org": "China Institute of Atomic Energy, Beijing, 102413 China"
            },
            {
                "name": "ErTao Li",
                "org": "China Institute of Atomic Energy, Beijing, 102413 China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy, Beijing, 102413 China"
            },
            {
                "name": "YunJu Li",
                "org": "China Institute of Atomic Energy, Beijing, 102413 China"
            },
            {
                "name": "XiXiang Bai",
                "org": "China Institute of Atomic Energy, Beijing, 102413 China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy, Beijing, 102413 China"
            },
            {
                "name": "YouBao Wang",
                "org": "China Institute of Atomic Energy, Beijing, 102413 China"
            },
            {
                "name": "YongShou Chen",
                "org": "China Institute of Atomic Energy, Beijing, 102413 China"
            },
            {
                "name": "SuQing Hou",
                "org": "China Institute of Atomic Energy, Beijing, 102413 China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy, Beijing, 102413 China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy, Beijing, 102413 China"
            },
            {
                "name": "JianRong Shi",
                "org": "National Astronomical Observatories, Chinese Academy of Sciences, Beijing, 100012 China"
            },
            {
                "name": "WeiPing Liu",
                "org": "China Institute of Atomic Energy, Beijing, 102413 China"
            }
        ],
        "venue": "Science China-physics Mechanics & Astronomy",
        "year": 2011
    },
    "6jXMbhlD": {
        "id": "6jXMbhlD",
        "title": "Measurement of the angular distribution for the 7Be(d, n)8B reaction and determination of the astrophysical S factor for the 7Be(p, \ufffd\ufffd)8B reaction",
        "abstract": "The differential cross section for the 7Be(d, n)8B reaction at Ec.m.=5.8 MeV has been measured using a 7Be beam produced by the radioactive nuclear beam facility at the China Institute of Atomic Energy. The 8B ions were detected in full geometry with a two dimensional position sensitive \ufffd\ufffdE-E counter telescope. The reaction cross section was determined to be 58\ufffd\ufffd8 mb. The angular distribution data were analyzed with a distorted-wave Born approximation calculation. The astrophysical S17(0) factor for the 7Be(p, \ufffd\ufffd)8B reaction was derived to be 27.4\ufffd\ufffd4.4 eV b through the asymptotic normalization constant extracted from the experimental data.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shuhua Zhou",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhanwen Ma",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhichang Li.",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "AnLi Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhongyu Ma",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "BaoQiu Chen",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xiaodong Tang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yinlu Han",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Qingbiao Shen",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jincheng Xu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Nuclear Physics A",
        "year": 1997
    },
    "3DZVY8Ip": {
        "id": "3DZVY8Ip",
        "title": "A proposed direct measurement of cross section at Gamow window for key reaction 19F(p,\u03b1) 16O in Asymptotic Giant Branch stars with a planned accelerator in CJPL",
        "abstract": "In 2014, the National Natural Science Foundation of China (NSFC) approved the Jinping Underground Nuclear Astrophysics laboratory (JUNA) project, which aims at direct cross-section measurements of four key stellar nuclear reactions right down to the Gamow windows. In order to solve the observed fluorine overabundances in Asymptotic Giant Branch (AGB) stars, measuring the key 19F(p,\u03b1)16O reaction at effective burning energies (i.e., at Gamow window) is established as one of the scientific research sub-projects. The present paper describes this sub-project in details, including motivation, status, experimental setup, yield and background estimation, aboveground test, as well as other relevant reactions.",
        "keywords": [
            "Jinping Underground Nuclear Astrophysics laboratory (JUNA)",
            " direct measurement",
            " Gamow window",
            " cross section",
            " AGB star",
            " nucleosynthesis"
        ],
        "authors": [
            {
                "name": "JianJun He",
                "org": "Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China"
            },
            {
                "name": "ShiWei Xu",
                "org": "Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China"
            },
            {
                "name": "ShaoBo Ma",
                "org": "Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China"
            },
            {
                "name": "Jun Hu",
                "org": "Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China"
            },
            {
                "name": "LiYong Zhang",
                "org": "Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China"
            },
            {
                "name": "ChangBo Fu",
                "org": "Department of Physics, Shanghai Jiao Tong University, Shanghai, China"
            },
            {
                "name": "NingTao Zhang",
                "org": "Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "YunJu Li",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "ShengQuan Yan",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "YangPing Shen",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "SuQing Hou",
                "org": "Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China"
            },
            {
                "name": "BaoLu Jia",
                "org": "Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China"
            },
            {
                "name": "Tao Zhang",
                "org": "Department of Physics, Shanghai Jiao Tong University, Shanghai, China"
            },
            {
                "name": "XiaoPeng Zhang",
                "org": "Department of Physics, Shanghai Jiao Tong University, Shanghai, China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Shigeru Kubono",
                "org": "Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China"
            },
            {
                "name": "WeiPing Liu",
                "org": "China Institute of Atomic Energy, Beijing, China"
            }
        ],
        "venue": "Science China-physics Mechanics & Astronomy",
        "year": 2016
    },
    "8mgoYthb": {
        "id": "8mgoYthb",
        "title": "New determination of the 13C(\u03b1, n) 16O reaction rate and its influence on the s-process nucleosynthesis in AGB stars",
        "abstract": "We present a new measurement of the \u03b1-spectroscopic factor (S \u03b1) and the asymptotic normalization coefficient for the 6.356MeV 1/2 + subthreshold state of 17O through the 13C( 11B, 7Li) 17O transfer reaction and we determine the \u03b1-width of this state. This is believed to have a strong effect on the rate of the 13C(\u03b1, n) 16O reaction, the main neutron source for slow neutron captures (the s-process) in asymptotic giant branch (AGB) stars. Based on the new width we derive the astrophysical S-factor and the stellar rate of the 13C(\u03b1, n) 16O reaction. At a temperature of 100 MK, our rate is roughly two times larger than that by Caughlan & Fowler and two times smaller than that recommended by the NACRE compilation. We use the new rate and different rates available in the literature as input in simulations of AGB stars to study their influence on the abundances of selected s-process elements and isotopic ratios. There are no changes in the final results using the different rates for the 13C(\u03b1, n) 16O reaction when the 13C burns completely in radiative conditions. When the 13C burns in convective conditions, as in stars of initial mass lower than \u223c2 M \u2299 and in post-AGB stars, some changes are to be expected, e.g., of up to 25% for Pb in our models. These variations will have to be carefully analyzed when more accurate stellar mixing models and more precise observational constraints are available. \u00a9 2012 The American Astronomical Society. All rights reserved.",
        "keywords": [
            "nuclear reactions",
            " nucleosynthesis",
            " abundances",
            "stars: AGB and post-AGB"
        ],
        "authors": [
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Maria A. Lugaro",
                "org": "Monash University(Monash University),Melbourne,Australia"
            },
            {
                "name": "Joelene Buntain",
                "org": "Monash University(Monash University),Melbourne,Australia"
            },
            {
                "name": "Danyang Pang",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "YunJu Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yongshou Chen",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Qiwen Fan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "SunJun Jin",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Amanda I. Karakas",
                "org": "Mount Stromlo Observatory(Mount Stromlo Observatory,Mt. Stromlo Siding Spring O.,Mount Stromlo and Siding Spring Observatories),,Australia"
            },
            {
                "name": "Ertao Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhichang Li.",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "JianCheng Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xin Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jianrong Shi",
                "org": "National Astronomical Observatories Chinese Academy of Sciences(Chinese Academy of Sciences,National Astronomical Observatories),Beijing,China"
            },
            {
                "name": "Nengchuan Shu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Astrophysical Journal",
        "year": 2012
    },
    "40CpSbkM": {
        "id": "40CpSbkM",
        "title": "Radius of 9C from the asymptotic normalization coefficient",
        "abstract": "The asymptotic normalization coefficient (ANC) of 9C \u2264 8B+p deduced from 8Li(d,p) 9Li reaction is used to obtain the root-mean-square (rms) radius of the loosely bound proton in the 9C ground state. We obtain \u3009r 2\u3008 1/2 \u2264 3.61 fm for the valence proton, which is significantly larger than the matter radius of 9C. The probability of the valence proton outside the matter radius of 9C is greater than 60%. The present work supports the conclusion that 9C has a proton halo structure. \u00a92005 Chinese Physical Society and IOP Publishing Ltd.",
        "keywords": [
            "ground state",
            "root mean square"
        ],
        "authors": [
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2005
    },
    "s46geZlb": {
        "id": "s46geZlb",
        "title": "A facility for production and utilization of radioactive beams",
        "abstract": "",
        "keywords": [
            "ion beam",
            "inverse kinematics"
        ],
        "authors": [
            {
                "name": "xixiang bai",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "jiuchang qin",
                "org": ""
            },
            {
                "name": "zhichang li",
                "org": ""
            },
            {
                "name": "shuhua zhou",
                "org": ""
            },
            {
                "name": "anli li",
                "org": ""
            },
            {
                "name": "youbao wang",
                "org": ""
            },
            {
                "name": "yehao cheng",
                "org": ""
            },
            {
                "name": "zhao wenrong",
                "org": ""
            }
        ],
        "venue": "Nuclear Physics A",
        "year": 1995
    },
    "Mzs0FnGG": {
        "id": "Mzs0FnGG",
        "title": "Angular Distribution for the Be-7 (d, n) B-8 Reaction at Ec.m.=5.8 MeV and the S-17 (0) Factor for the Be-7 (p, gamma) B-8 Reaction",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Zhongyu Ma",
                "org": ""
            },
            {
                "name": "Qingbiao Shen",
                "org": ""
            },
            {
                "name": "X.D. Bai",
                "org": ""
            },
            {
                "name": "Baoqiu Chen",
                "org": ""
            },
            {
                "name": "Yinlu Han",
                "org": ""
            },
            {
                "name": "Zhichang Li",
                "org": ""
            },
            {
                "name": "Zhanwen Ma",
                "org": ""
            },
            {
                "name": "Xiaodong Tang",
                "org": ""
            },
            {
                "name": "Youbao Wang",
                "org": ""
            },
            {
                "name": "Anli Li",
                "org": ""
            },
            {
                "name": "Shuhua Zhou",
                "org": ""
            }
        ],
        "venue": "Physical Review Letters",
        "year": 1996
    },
    "VP2dz1Aj": {
        "id": "VP2dz1Aj",
        "title": "NUCLEAR AND HEAVY ION PHYSICS: Simulation and analysis of 13N+p elastic resonance scattering",
        "abstract": "",
        "keywords": [
            "monte carlo simulation",
            "inverse kinematics"
        ],
        "authors": [
            {
                "name": "youbao wang",
                "org": ""
            },
            {
                "name": "xing qin",
                "org": ""
            },
            {
                "name": "baoxiang wang",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "zhihong li",
                "org": ""
            },
            {
                "name": "xixiang bai",
                "org": ""
            },
            {
                "name": "gang lian",
                "org": ""
            },
            {
                "name": "bing guo",
                "org": ""
            },
            {
                "name": "sheng zeng",
                "org": ""
            },
            {
                "name": "jun su",
                "org": ""
            },
            {
                "name": "yunju li",
                "org": ""
            },
            {
                "name": "chao jiang",
                "org": ""
            }
        ],
        "venue": "Chinese Physics C",
        "year": 2009
    },
    "K0HkIfZW": {
        "id": "K0HkIfZW",
        "title": "Indirect measurement of astrophysical 13C(\u03b1, n) 16O S-factors",
        "abstract": "The 13C(\u03b1, n) 16O reaction is believed to be the main neutron source reaction for the s-process in asymptotic giant branch (AGB) stars. The astrophysical S-factors of this reaction have been determined based on an evaluation of the \u03b1 spectroscopic factor of the 1/2 + subthreshold state in 17O (E x = 6.356 MeV) by using the 13C( 11B, 7Li) 17O \u03b1 transfer reaction. Our result confirms that the 1/2 + subthreshold resonance is dominant for the 13C(\u03b1, n) 16O reaction at low energies of astrophysical interest.",
        "keywords": [
            "elastic scattering",
            "s-process",
            "transfer reaction"
        ],
        "authors": [
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "YunJu Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yongshou Chen",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Qiwen Fan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "SunJun Jin",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Ertao Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhichang Li.",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xin Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "JianCheng Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Nengchuan Shu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Danyang Pang",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Maria A. Lugaro",
                "org": "Monash University(Monash University),Melbourne,Australia"
            },
            {
                "name": "Joelene Buntain",
                "org": "Monash University(Monash University),Melbourne,Australia"
            }
        ],
        "venue": "\u7b49\u79bb\u5b50\u4f53\u79d1\u5b66\u4e0e\u6280\u672f(\u82f1\u6587\u7248)",
        "year": 2012
    },
    "HGCHsUUj": {
        "id": "HGCHsUUj",
        "title": "Asymptotic Normalization Coefficient of27P \u219226Si +pand Radius of27P Halo",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Guo Bing",
                "org": ""
            },
            {
                "name": "Li Zhi-Hong",
                "org": ""
            },
            {
                "name": "Liu Wei-Ping",
                "org": ""
            },
            {
                "name": "Bai Xi-Xiang",
                "org": ""
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2006
    },
    "6Jook7rR": {
        "id": "6Jook7rR",
        "title": "Neutron Spectroscopic Factors of7Li and Astrophysical6Li(n,\u03b3)7Li Reaction Rates",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Su Jun",
                "org": ""
            },
            {
                "name": "Li Zhi-Hong",
                "org": ""
            },
            {
                "name": "Guo Bing",
                "org": ""
            },
            {
                "name": "Bai Xi-Xiang",
                "org": ""
            },
            {
                "name": "Li Zhi-Chang",
                "org": ""
            },
            {
                "name": "Liu Jian-Cheng",
                "org": ""
            },
            {
                "name": "Wang You-Bao",
                "org": ""
            },
            {
                "name": "Lian Gang",
                "org": ""
            },
            {
                "name": "Zeng Sheng",
                "org": ""
            },
            {
                "name": "Wang Bao-Xiang",
                "org": ""
            },
            {
                "name": "Yan Sheng-Quan",
                "org": ""
            },
            {
                "name": "Li Yun-Ju",
                "org": ""
            },
            {
                "name": "Li Er-Tao",
                "org": ""
            },
            {
                "name": "Fan Qi-Wen",
                "org": ""
            },
            {
                "name": "Liu Wei-Ping",
                "org": ""
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2010
    },
    "CNObxMZJ": {
        "id": "CNObxMZJ",
        "title": "Parametrization of woods-saxon potential for heavy-ion systems",
        "abstract": "Several elastic scattering angular distributions of 12C from target nuclei of A \u2265 39 are analyzed to extract theWoods-Saxon potential parameters with the fixed imaginary potential and Coulomb radius parameters. Using the best fitted diffuseness parameters, the correlations of the real part parameters with A 1 1/3 + A 2 1/3 and incident energy are revealed, and the systematic Woods-Saxon potential parameters are presented for nucleus-nucleus interaction. The proposed potential parameters can reproduce not only the elastic scattering angular distributions induced by 12C, but also many elastic scattering angular distributions induced by the projectiles other than 12C, thus providing important inputs for the study of nuclear reactions of heavy-ion systems.",
        "keywords": "",
        "authors": [
            {
                "name": "L. Gan",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "H. B. Sun",
                "org": "College of Physics and Energy, Shenzhen University, Shenzhen, China"
            },
            {
                "name": "D. Y. Pang",
                "org": "School of Physics and Nuclear Energy Engineering, Beihang University, Beijing, China"
            },
            {
                "name": "B. Guo",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Y. J. Li",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Er-Tao Li",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "G. Lian",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "ZhiYu Han",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "XinYue Li",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "DongHui Li",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "TianLi Ma",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "ChangJin Pei",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Y. P. Shen",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Yi Su",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "S. Zeng",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Yong Zhou",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy, Beijing, China"
            }
        ],
        "venue": "Science China-physics Mechanics & Astronomy",
        "year": 2017
    },
    "R3nTWvp0": {
        "id": "R3nTWvp0",
        "title": "Test of determination of (p, \u03b3) astrophysical S-factors using the asymptotic normalization coefficients from neutron transfer reactions",
        "abstract": "The asymptotic normalization coefficients (ANCs) for the virtual decay 17O\u219216O+n are derived from the angular distributions of the 16O(d,p)17O reaction leading to the ground and first excited states of 17O, respectively, using the distorted wave Born approximation and the adiabatic wave approximation. The ANCs of 17F are then extracted according to charge symmetry of mirror nuclei and used to calculate the astrophysical S-factors of 16O(p,\u03b3) 17F leading to the first two states of 17F. The present results are in good agreement with those from the direct measurement. This provides a test of this indirect method to determine direct astrophysical S-factors of (p,\u03b3) reaction. In addition, the S-factors at zero energy for the direct captures to the ground and first excited states of 17F are presented, without the uncertainty associated with the extrapolation from higher energies in direct measurement. \u00a92007 Chinese Physical Society and IOP Publishing Ltd.",
        "keywords": [
            "excited states"
        ],
        "authors": [
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Li Zhi-Hong",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Liu Wei-Ping",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bai Xi-Xiang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2007
    },
    "eLWxce9D": {
        "id": "eLWxce9D",
        "title": "Angular distribution of 6He+p elastic scattering",
        "abstract": "The angular distribution of 1H( 6He,p) 6He elastic scattering has been measured at E c.m. = 4.3 MeV by using a thick-target inverse kinematic method. The experimental differential cross sections are reproduced by the distorted-wave Born approximation calculation utilizing the CH89 global optical potential parameter set. The real part of CH89 is reduced comparing with other potentials, which may be attributed to the couplings necessary for the weakly bound nuclei. \u00a9 2012 Chinese Physical Society and the Institute of High Energy Physics of the Chinese Academy of Sciences and the Institute of Modern Physics of the Chinese Academy of Sciences and IOP Publishing Ltd.",
        "keywords": [
            "angular distribution",
            "elastic scattering",
            "thick-target method",
            "cross section",
            "inverse kinematics"
        ],
        "authors": [
            {
                "name": "Xin Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "WANG You-Bao",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "LI Zhi-Hong",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "JIN Sun-Jun",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "WANG Bao-Xiang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "LI Yun-Ju",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "LI Er-Tao",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "BAI Xi-Xiang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "YAN Sheng-Quan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "HUANG Wu-Zhen",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "LIU Wei-Ping",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Chinese Physics C",
        "year": 2012
    },
    "aCnXEiJq": {
        "id": "aCnXEiJq",
        "title": "Astrophysical Rates for the6He(p, \u03b3)7Li Reaction",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Er-Tao Li",
                "org": ""
            },
            {
                "name": "Zhi-Hong Li",
                "org": ""
            },
            {
                "name": "Jun Su",
                "org": ""
            },
            {
                "name": "Bing Guo",
                "org": ""
            },
            {
                "name": "Yun-Ju Li",
                "org": ""
            },
            {
                "name": "Sheng-Quan Yan",
                "org": ""
            },
            {
                "name": "Xi-Xiang Bai",
                "org": ""
            },
            {
                "name": "You-Bao Wang",
                "org": ""
            },
            {
                "name": "Bao-Xiang Wang",
                "org": ""
            },
            {
                "name": "Gang Lian",
                "org": ""
            },
            {
                "name": "Sheng Zeng",
                "org": ""
            },
            {
                "name": "Xiao Fang",
                "org": ""
            },
            {
                "name": "Wei-Juan Zhao",
                "org": ""
            },
            {
                "name": "Wei-Ping Liu",
                "org": ""
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2011
    },
    "ryTfbSEB": {
        "id": "ryTfbSEB",
        "title": "Calculation Method of Absorption Efficiency for Charged Particle Emission in Silicon Detector",
        "abstract": "By using the energy loss calculation and layer approximation,the calculation method of absorption efficiency for charged particle emission in silicon detector was developed.The calculated result is in good agreement with experiments.This method provides a simple and reliable tool for getting the absorption efficiency.",
        "keywords": [
            "Absorption efficiency",
            "Charge particle emission",
            "Energy loss"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "China Institute of Atomic Energy,P.O.Box 275-1,Beijing ,China"
            }
        ],
        "venue": "Atomic Energy Science and Technology",
        "year": 2007
    },
    "AeLFqVfB": {
        "id": "AeLFqVfB",
        "title": "Beam-Monitoring Time of Flight System With Plastic Scintillator",
        "abstract": "A beam-monitoring time of flight(TOF) system is installed on the secondary beam line at the Beijing HI-13 Tandem Laboratory.The TOF system adopts plastic scintillation coupled with fast photomultiplier tube,and is intended the identification of the secondary beam and the determination of energy.Its performance is presented and discussed together with a recent 1H(17F,p)17F elastic resonance scattering measurement.",
        "keywords": [
            "secondary radioactive nuclear beams",
            "thick-target yield measurement",
            "time of flight method",
            "plastic scintillator"
        ],
        "authors": [
            {
                "name": "QIN Xing",
                "org": "China Institute of Atomic Energy,P.O.Box 275-46,Beijing ,China;Shanxi Normal University,Linfen ,China"
            },
            {
                "name": "WANG You-bao",
                "org": "China Institute of Atomic Energy,P.O.Box 275-46,Beijing ,China"
            },
            {
                "name": "WANG Bao-xiang",
                "org": "China Institute of Atomic Energy,P.O.Box 275-46,Beijing ,China"
            },
            {
                "name": "BAI Xi-xiang",
                "org": "China Institute of Atomic Energy,P.O.Box 275-46,Beijing ,China"
            },
            {
                "name": "GUO Bing",
                "org": "China Institute of Atomic Energy,P.O.Box 275-46,Beijing ,China"
            },
            {
                "name": "LI Zhi-hong",
                "org": "China Institute of Atomic Energy,P.O.Box 275-46,Beijing ,China"
            },
            {
                "name": "LIAN Gang",
                "org": "China Institute of Atomic Energy,P.O.Box 275-46,Beijing ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "China Institute of Atomic Energy,P.O.Box 275-46,Beijing ,China"
            },
            {
                "name": "SU Jun",
                "org": "China Institute of Atomic Energy,P.O.Box 275-46,Beijing ,China"
            },
            {
                "name": "YAN Sheng-quan",
                "org": "China Institute of Atomic Energy,P.O.Box 275-46,Beijing ,China"
            },
            {
                "name": "ZENG Sheng",
                "org": "China Institute of Atomic Energy,P.O.Box 275-46,Beijing ,China"
            }
        ],
        "venue": "Atomic Energy Science and Technology",
        "year": 2008
    },
    "to0wPjUq": {
        "id": "to0wPjUq",
        "title": "Calibration of neutron detection efficiency for a stilbene scintillator detector in the energy range of 18-27MeV",
        "abstract": "The neutron detection efficiency of a stilbene scintillator was calibrated in the energy range from 18MeV to 27MeV by measuring the angular distribution of the neutrons emitted from the T(d,n)4He reaction at 10MeV, the experimental data points were then connected with the curve obtained from calculation below 20MeV so that to form a complete curve of relative efficiency. The method can also be used for other organic scintillators.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Xiaozhong Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "AnLi Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Dahai Chin",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yuan Yuan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Yuanzineng Kexue Jishu/Atomic Energy Science and Technology",
        "year": 1995
    },
    "fRTPSG6U": {
        "id": "fRTPSG6U",
        "title": "Determination of the 12 C( p, ? ) 13 N reaction rates from the 12",
        "abstract": "",
        "keywords": [
            "reaction rate"
        ],
        "authors": [
            {
                "name": "zhihong li",
                "org": ""
            },
            {
                "name": "jun su",
                "org": ""
            },
            {
                "name": "bing guo",
                "org": ""
            },
            {
                "name": "xixiang bai",
                "org": ""
            },
            {
                "name": "jiancheng liu",
                "org": ""
            },
            {
                "name": "yunju li",
                "org": ""
            },
            {
                "name": "shengquan yan",
                "org": ""
            },
            {
                "name": "baoxiang wang",
                "org": ""
            },
            {
                "name": "youbao wang",
                "org": ""
            },
            {
                "name": "gang lian",
                "org": ""
            },
            {
                "name": "sheng zeng",
                "org": ""
            },
            {
                "name": "ertao li",
                "org": ""
            },
            {
                "name": "yongshou chen",
                "org": ""
            },
            {
                "name": "nengchuan shu",
                "org": ""
            },
            {
                "name": "q fan",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            }
        ],
        "venue": "Science China-physics Mechanics & Astronomy",
        "year": 2010
    },
    "sW2aVFim": {
        "id": "sW2aVFim",
        "title": "Study of (p,\u03b3) Reactions on Short-Lived Nuclei Using Transfer Reaction of Mirror Nuclei",
        "abstract": "An indirect method that using neutron transfer reaction and charge symmetry of mirror nuclei,was introduced to study(p,\u03b3) reactions on proton rich nuclei.It can contribute to the good use of radioactive secondary ion beams produced by GIRAFFE,the secondary beam facility at HI-13 tandem accelerator,and indirectly extract the proton capture cross section which has not been available to date or reduce its uncertainty(compared with the preexisting results).We measured the 8Li(d,p)9Li angular distribution in inverse kinematics at GIRAFFE,and then derived the contribution of direct capture in 8B(p,\u03b3)9C through this indirect approach.This work provides an independent examination to the existing results for 8B(p,\u03b3)9C.In addition,we reanalyzed the angular distributions of 26Si(p,\u03b3)27P leading to the ground,the first and the second excited states of 27P,and then indirectly extracted the contribution of direct and resonant captures in 26Si(p,\u03b3)27P.The direct capture contribution is experimentally obtained for the first time.The approach described here can be also used for the study of many reactions of astrophysical importance.",
        "keywords": [
            "Astrophysical S-factor",
            "Asymptotic normalization coefficient",
            "Mirror nuclei",
            "Reaction rate"
        ],
        "authors": [
            {
                "name": "GUO Bing",
                "org": "Department of Nuclear Physics,China Institute of Atomic Energy,Beijing ,China"
            },
            {
                "name": "LI Zhi-hong",
                "org": "Department of Nuclear Physics,China Institute of Atomic Energy,Beijing ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Nuclear Physics,China Institute of Atomic Energy,Beijing ,China"
            },
            {
                "name": "BAI Xi-xiang",
                "org": "Department of Nuclear Physics,China Institute of Atomic Energy,Beijing ,China"
            },
            {
                "name": "LIAN Gang",
                "org": "Department of Nuclear Physics,China Institute of Atomic Energy,Beijing ,China"
            },
            {
                "name": "YAN Sheng-quan",
                "org": "Department of Nuclear Physics,China Institute of Atomic Energy,Beijing ,China"
            },
            {
                "name": "WANG Bao-xiang",
                "org": "Department of Nuclear Physics,China Institute of Atomic Energy,Beijing ,China"
            },
            {
                "name": "SU Jun",
                "org": "Department of Nuclear Physics,China Institute of Atomic Energy,Beijing ,China"
            },
            {
                "name": "WANG You-bao",
                "org": "Department of Nuclear Physics,China Institute of Atomic Energy,Beijing ,China"
            },
            {
                "name": "ZENG Sheng",
                "org": "Department of Nuclear Physics,China Institute of Atomic Energy,Beijing ,China"
            },
            {
                "name": "SHU Neng-chuan",
                "org": "Department of Nuclear Physics,China Institute of Atomic Energy,Beijing ,China"
            },
            {
                "name": "CHEN Yong-shou",
                "org": "Department of Nuclear Physics,China Institute of Atomic Energy,Beijing ,China"
            }
        ],
        "venue": "Atomic Energy Science and Technology",
        "year": 2007
    },
    "FxgGUbBy": {
        "id": "FxgGUbBy",
        "title": "Properties of fluorine targets and their application on the astrophysically important 19F(p,\u03b1)16O reaction",
        "abstract": "Abstract   We report on the production and testing of both evaporated and implanted fluorine targets to investigate their stability to irradiation by protons. We produced four targets by evaporating CaF 2  and LiF powder on Ta backings and three targets by implanting 30\u202fkeV  19 F ions into stainless steel backings; a     5    \u03bc    g/cm 2  Cr protective layer was also evaporated on one of these implanted targets. We assessed each target\u2019s stability by monitoring the     \u03b3    -ray yields of the  19 F(    p  ,    \u03b1    \u03b3      ) 16 O reaction. Our results indicate that the evaporated and implanted targets without Cr layer exhibited 30    %  \u223c    75% and 13% deterioration after     \u223c    2.5\u202fCoulomb/cm 2 , 220\u2013270\u202fkeV proton bombardment, respectively. The implanted target with protecting layer exhibited only about 2.5% deterioration, which can be regarded as stable. As we observed stability in one of the CaF 2  evaporated targets up to 0.25\u202fCoulomb/cm 2  irradiation, this target was used to investigate the two resonances at       E    p    =  225     and 237\u202fkeV of the  19 F(    p  ,    \u03b1    \u03b3      ) 16 O reaction; the resonance parameters we extracted are consistent with the values found in the literature, giving us confidence in our analysis methods and our understanding of the target fabrication procedures described herein. In conclusion, the implantation technique provides a unique means to produce fluorine targets capable of withstanding high beam intensities, which is one of the necessary technical developments for the JUNA (Jinping Underground Nuclear Astrophysics) project in China.",
        "keywords": "",
        "authors": [
            {
                "name": "Liyong Zhang",
                "org": "Key Laboratory of Optical Astronomy, National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012, China"
            },
            {
                "name": "Shiwei Xu",
                "org": "Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "Jianjun He",
                "org": "Key Laboratory of Optical Astronomy, National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012, China"
            },
            {
                "name": "Shuo Wang",
                "org": "School of Space Science and Physics, Shandong University at Weihai, Weihai 264209, China"
            },
            {
                "name": "Han Chen",
                "org": "Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "Jun Hu",
                "org": "Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "Shaobo Ma",
                "org": "Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "Ningtao Zhang",
                "org": "Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "Suqing Hou",
                "org": "Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy, Beijing 102413, China"
            }
        ],
        "venue": "Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms",
        "year": 2019
    },
    "ETQ5cdfw": {
        "id": "ETQ5cdfw",
        "title": "Determination of the astrophysical S(E) factors or rates for radiative capture reaction with one nucleon transfer reaction",
        "abstract": "The radiative capture reaction plays an important role in nuclear astrophysics. We have indirectly measured the astrophysical S(E) factors for some proton capture reactions and reaction rates for several neutron capture reactions with one nucleon transfer reactions at HI-13 tandem accelerator in recent years. Some of them are compiled into IAEA EXFOR database and JINA REACLIB project, and used in the network calculations of Big Bang nucleosynthesis and type-I X-ray bursts.",
        "keywords": [
            "nucleosynthesis",
            "radiative capture",
            "spectroscopic factor",
            "transfer reaction"
        ],
        "authors": [
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "YunJu Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Ertao Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhichang Li.",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "JianCheng Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "SunJun Jin",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xin Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "\u7b49\u79bb\u5b50\u4f53\u79d1\u5b66\u4e0e\u6280\u672f(\u82f1\u6587\u7248)",
        "year": 2012
    },
    "IQdor22I": {
        "id": "IQdor22I",
        "title": "Study of neutron source reaction 13C(\ufffd\ufffd, n)16O in stars",
        "abstract": "13C(\ufffd\ufffd,n)16O is the main neutron source reaction of slow neutron capture (s) process in asymptotic giant branch (AGB) stars. The 6.356 MeV 1/2+ subthreshold resonance in 17O plays an important role in the 13C(\ufffd\ufffd,n)16O reaction. The 13C(11B, 7Li)17O angular distributions were measured using HI-13 tandem accelerator and Q3D magnetic spectrograph, and then used to determine the \ufffd\ufffd-width of the subthreshold resonant state which is currently the most uncertain parameter for determining the 13C(\ufffd\ufffd,n)16O reaction rate. By using the present \ufffd\ufffd-width, the astrophysical S-factor and the stellar rate of the 13C(\ufffd\ufffd,n)16O reaction were derived. This shed some light on the existing discrepancies up to a factor of 25 in S-factors derived from different authors. The simulation of s-process in AGB stars shows that the new reaction rate produces 25% more Pb than the CF88 compilation.",
        "keywords": [
            "AGB stars",
            "Angular distribution of transfer reaction",
            "Astrophysical S-factor",
            "s-process",
            "Subthreshold resonance"
        ],
        "authors": [
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Maria A. Lugaro",
                "org": "Monash University(Monash University),Melbourne,Australia"
            },
            {
                "name": "Joelene Buntain",
                "org": "Monash University(Monash University),Melbourne,Australia"
            },
            {
                "name": "Danyang Pang",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Yunju Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhidan Wu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yongshou Chen",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xianchao Du",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Qi Fan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Lin Gan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sunjun Jin",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Amanda I. Karakas",
                "org": "Mount Stromlo Observatory(Mount Stromlo Observatory,Mt. Stromlo Siding Spring O.,Mount Stromlo and Siding Spring Observatories),,Australia"
            },
            {
                "name": "Ertao Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhichang Li.",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jiancheng Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xin Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jianrong Shi",
                "org": "National Astronomical Observatories Chinese Academy of Sciences(Chinese Academy of Sciences,National Astronomical Observatories),Beijing,China"
            },
            {
                "name": "Nengchuan Shu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Yuanzineng Kexue Jishu/Atomic Energy Science and Technology",
        "year": 2014
    },
    "3JqbwI1W": {
        "id": "3JqbwI1W",
        "title": "Determination of astrophysical S-factor via measurement of reaction",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "zhihong li",
                "org": ""
            },
            {
                "name": "xixiang bai",
                "org": ""
            },
            {
                "name": "bing guo",
                "org": ""
            },
            {
                "name": "sheng zeng",
                "org": ""
            },
            {
                "name": "yongshou chen",
                "org": ""
            },
            {
                "name": "shengquan yan",
                "org": ""
            },
            {
                "name": "baoxiang wang",
                "org": ""
            },
            {
                "name": "gang lian",
                "org": ""
            },
            {
                "name": "yun lu",
                "org": ""
            },
            {
                "name": "kaisu wu",
                "org": ""
            },
            {
                "name": "nengchuan shu",
                "org": ""
            }
        ],
        "venue": "Nuclear Physics",
        "year": 2003
    },
    "Gn163Dtk": {
        "id": "Gn163Dtk",
        "title": "Improving the 33S(p,\u03b3)34Cl reaction rate for models of classical nova explosions",
        "abstract": "Reduced uncertainty in the thermonuclear rate of the 33S(p, \u03b3)34Cl reaction would help to improve our understanding of nucleosynthesis in classical nova explosions. At present, models are generally in concordance with observations that nuclei up to roughly the calcium region may be produced in these explosive phenomena; better knowledge of this rate would help with the quantitative interpretation of nova observations over the S-Ca mass region, and contribute towards the firm establishment of a nucleosynthetic endpoint. As well, models find that the ejecta of nova explosions on massive oxygen-neon white dwarfs may contain as much as 150 times the solar abundance of 33S. This characteristic isotopic signature of a nova explosion could possibly be observed through the analysis of microscopic grains formed in the environment surrounding a nova and later embedded within primitive meteorites. An improved 33S(p,\u03b3)34Cl rate (the principal destruction mechanism for 33S in novae) would help to ensure a robust model prediction for the amount of 33S that may be produced. Finally, constraining this rate could confirm or rule out the decay of an isomeric state of 34Cl (Ex=146keV, t 1/2=32m) as a source for observable gamma-rays from novae. We have performed several complementary experiments dedicated to improving our knowledge of the 33S(p,\u03b3)34Cl rate, using both indirect methods (measurement of the 34S(3He,t)34Cl and 33S(3He,d)34Cl reactions with the Munich Q3D spectrograph) and direct methods (in normal kinematics at CENPA, University of Washington, and in inverse kinematics with the DRAGON recoil mass separator at TRIUMF). Our results will be used with nova models to facilitate comparisons of model predictions with present and future nova observables. \u00a9 2011 American Institute of Physics.",
        "keywords": [
            "classical nova explosions",
            "experimental nuclear physics",
            "Nuclear astrophysics"
        ],
        "authors": [
            {
                "name": "Anuj R. Parikh",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Th Faestermann",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Reiner Kr\u00fccken",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Vinzenz Bildstein",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Shawn M. Bishop",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Katrin Eppinger",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Clemens Herlitzius",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Olga A. Lepyoshkina",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Peter Maierbeck",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Dominik Seiler",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Kathrin Wimmer",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Ralf Hertenberger",
                "org": "Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen(University of Munich),M\u00fcnchen,Germany"
            },
            {
                "name": "Hans Friedrich Wirth",
                "org": "Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen(University of Munich),M\u00fcnchen,Germany"
            },
            {
                "name": "Jennifer Fallis",
                "org": "TRIUMF(TRIUMF),Vancouver,Canada"
            },
            {
                "name": "Ulf H\u00e4ger",
                "org": "TRIUMF(TRIUMF),Vancouver,Canada"
            },
            {
                "name": "Dave A. Hutcheon",
                "org": "TRIUMF(TRIUMF),Vancouver,Canada"
            },
            {
                "name": "Chris Ruiz",
                "org": "TRIUMF(TRIUMF),Vancouver,Canada"
            },
            {
                "name": "Lothar R. Buchmann",
                "org": "TRIUMF(TRIUMF),Vancouver,Canada"
            },
            {
                "name": "Dave F. Ottewell",
                "org": "TRIUMF(TRIUMF),Vancouver,Canada"
            },
            {
                "name": "Blake M. Freeman",
                "org": "University of Washington Seattle(Univ. Washington,University of Washington),Seattle,United States"
            },
            {
                "name": "Chris Wrede",
                "org": "University of Washington Seattle(Univ. Washington,University of Washington),Seattle,United States"
            },
            {
                "name": "Alejandro R. Garc\u00eda",
                "org": "University of Washington Seattle(Univ. Washington,University of Washington),Seattle,United States"
            },
            {
                "name": "Brent G. Delbridge",
                "org": "University of Washington Seattle(Univ. Washington,University of Washington),Seattle,United States"
            },
            {
                "name": "Andreas Knecht",
                "org": "University of Washington Seattle(Univ. Washington,University of Washington),Seattle,United States"
            },
            {
                "name": "Anne L. Sallaska",
                "org": "University of Washington Seattle(Univ. Washington,University of Washington),Seattle,United States"
            },
            {
                "name": "Alan Chen",
                "org": "Technische Universit\u00e4t M\u00fcnchen(Technische Universit\u00e4t M\u00fcnchen),M\u00fcnchen,Germany"
            },
            {
                "name": "Jason A. Clark",
                "org": "Argonne National Laboratory(Argonne National Laboratory,Argonne Natl Lab),Argonne,United States"
            },
            {
                "name": "Catherine M. Deibel",
                "org": "Argonne National Laboratory(Argonne National Laboratory,Argonne Natl Lab),Argonne,United States"
            },
            {
                "name": "Brian R. Fulton",
                "org": "University of York(University of York),York,United Kingdom"
            },
            {
                "name": "Alison M. Laird",
                "org": "University of York(University of York),York,United Kingdom"
            },
            {
                "name": "Uwe Greife",
                "org": "Colorado School of Mines(Colorado School of Mines,Colorado Sch of Mines),Golden,United States"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Ertao Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Peter D. Parker",
                "org": "Yale University(Yale University),New Haven,United States"
            },
            {
                "name": "Kiana Setoodehnia",
                "org": "McMaster University(McMaster University),Hamilton,Canada"
            }
        ],
        "venue": "AIP Conference Proceedings",
        "year": 2011
    },
    "2lHnn2My": {
        "id": "2lHnn2My",
        "title": "Measurement of angular distribution for the 8Li(p, d) 7Li reaction",
        "abstract": "The 8Li(p, d)7Li reaction plays an important role in the inhomogeneous Big Bang nucleosynthesis and in the seed-nuclide production phase for the r-process. For the first time, its angular distribution at backward angles was measured in inverse kinematics at Ec.m. = 4.0 MeV by using an 8Li secondary beam. The result of measurement includes the contributions of 8Li(p, d0)7Li and 8Li(p, d1)7Li*. The 8Li(p, d0)7Li component is estimated to be 40%\u223c58% in the mixture angular distribution by analysing the measured result. \u00a9 2008 Chinese Physical Society and IOP Publishing Ltd.",
        "keywords": [],
        "authors": [
            {
                "name": "YunJu Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xing Qin",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Chao Jiang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "WeiJuan Zhao",
                "org": "Zhengzhou University(Zhengzhou University),Zhengzhou,China"
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2008
    },
    "mvW31TGK": {
        "id": "mvW31TGK",
        "title": "Measurement of2H(8Li,9Be)nReaction Relevant to Primordial Nucleosynthesis",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Zeng Sheng",
                "org": ""
            },
            {
                "name": "Liu Wei-Ping",
                "org": ""
            },
            {
                "name": "Li Zhi-Hong",
                "org": ""
            },
            {
                "name": "Bai Xi-Xiang",
                "org": ""
            },
            {
                "name": "Yan Sheng-Quan",
                "org": ""
            },
            {
                "name": "Wang Bao-Xiang",
                "org": ""
            },
            {
                "name": "Lian Gang",
                "org": ""
            },
            {
                "name": "Su Jun",
                "org": ""
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2005
    },
    "DXQWQEQ0": {
        "id": "DXQWQEQ0",
        "title": "Beam-monitoring time of flight system with plastic scintillator",
        "abstract": "A beam-monitoring time of flight (TOF) system is installed on the secondary beam line at the Beijing HI-13 Tandem Laboratory. The TOF system adopts plastic scintillation coupled with fast photomultiplier tube, and is intended the identification of the secondary beam and the determination of energy. Its performance is presented and discussed together with a recent 1H(17F, p)17F elastic resonance scattering measurement.",
        "keywords": [
            "Plastic scintillator",
            "Secondary radioactive nuclear beams",
            "Thick-target yield measurement",
            "Time of flight method"
        ],
        "authors": [
            {
                "name": "Xing Qin",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Yuanzineng Kexue Jishu/Atomic Energy Science and Technology",
        "year": 2008
    },
    "Sqlut0S0": {
        "id": "Sqlut0S0",
        "title": "Asymptotic normalization coefficient of 27P \u2192 26Si + p and radius of 27P halo",
        "abstract": "The asymptotic normalization coefficient of the virtual decay 27P \u2192 26Si + p is extracted to be 1840\u00b1240 fm -1 from the peripheral 26Mg(d,p) 27Mg reaction using charge symmetry of mirror pair, for the first time. It is then used to derive the rms radius of the valence proton in the ground state of 27P. We obtain the rms radius \u3008r 2\u3009 1/2 \u2264 4.57\u00b10.36 fm, significantly larger than the matter radius of 27P. The probability of the valence proton outside the matter radius of 27P is found to be 73%. The present work supports the conclusion that the 27P ground state has a proton halo structure. \u00a9 2005 Chinese Physical Society and IOP Publishing Ltd.",
        "keywords": [],
        "authors": [
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2006
    },
    "KVE3L3cf": {
        "id": "KVE3L3cf",
        "title": "Neutron spectroscopic factors of 7Li and astrophysical 6Li(n,g)7Li\n  reaction rates",
        "abstract": "Angular distributions of the 7Li(6Li,6Li)7Li elastic scattering and the\n7Li(6Li,7Li_{g.s.})6Li, 7Li(6Li,7Li*_{0.48})6Li transfer reactions at Ec.m. =\n23.7 MeV were measured with the Q3D magnetic spectrograph. The optical\npotential of 6Li+7Li was obtained by fitting the elastic scattering\ndifferential cross sections. Based on the distorted wave Born approximation\n(DWBA) analysis, spectroscopic factors of 7Li=6Li+n were determined to be 0.73\n+- 0.05 and 0.90 +- 0.09 for the ground and first exited states in 7Li,\nrespectively. Using the spectroscopic factors, the cross sections of the\n6Li(n,g)7Li direct neutron capture reactions and the astrophysical 6Li(n,g)7Li\nreaction rates were derived.",
        "keywords": [
            "elastic scattering",
            "reaction rate",
            "cross section"
        ],
        "authors": [
            {
                "name": "Jun Su",
                "org": ""
            },
            {
                "name": "Zhihong Li",
                "org": ""
            },
            {
                "name": "Bing Guo",
                "org": ""
            },
            {
                "name": "Xixiang Bai",
                "org": ""
            },
            {
                "name": "Zhichang Li",
                "org": ""
            },
            {
                "name": "Jiancheng Liu",
                "org": ""
            },
            {
                "name": "Youbao Wang",
                "org": ""
            },
            {
                "name": "Gang Lian",
                "org": ""
            },
            {
                "name": "Sheng Zeng",
                "org": ""
            },
            {
                "name": "Baoxiang Wang",
                "org": ""
            },
            {
                "name": "Shengquan Yan",
                "org": ""
            },
            {
                "name": "Yunju Li",
                "org": ""
            },
            {
                "name": "Ertao Li",
                "org": ""
            },
            {
                "name": "Qiwen Fan",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2010
    },
    "Jm3mJ1UY": {
        "id": "Jm3mJ1UY",
        "title": "Test of two dimensional position sensitive silicon detector",
        "abstract": "A two-dimensional position sensitive silicon detector was tested by using 239Pu \ufffd\ufffd source and Oxygen and Carbon beams accelerated to 40 MeV and 70 MeV. The results indicate that better position resolution can be obtained when the sum of the four position signals is replaced by the energy signal in the position formula. The shaping time of the main amplifier has great influence on the position resolution.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "AnLi Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shuhua Zhou",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Guojian Si",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhichang Li.",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Yuanzineng Kexue Jishu/Atomic Energy Science and Technology",
        "year": 1994
    },
    "kSm02d4e": {
        "id": "kSm02d4e",
        "title": "Determination of astrophysical 11C(p, \u03b3)12N reaction rate from the asymptotic normalization coefficients of 12B \u219211B + n",
        "abstract": "The squares of the neutron asymptotic normalization coefficient (ANC) for the virtual decay 12B \u219211B + n are extracted to be 1.20 \u00b1 0.26, 0.354 \u00b1 0.107 and 1.98 \u00b1 0.35 fm-1 from the angular distributions of the 11B(d, p)12B reaction leading to the ground, first and second excited states of 12B respectively, using the Johnson-Soper approach. According to charge symmetry of strong interaction, the square of proton ANC of virtual decay 12N \u219211C + p is determined to be 1.63 \u00b1 0.35 fm-1 and then utilized to calculate the astrophysical S-factor and the rate of the direct capture contribution in the 11C(p, \u03b3)12N reaction. The astrophysical S-factor at zero energy for the direct capture, S(0), is derived to be 0.088 \u00b1 0.019 keV b. An evaluated S(0) of 0.092 \u00b1 0.009 keV b is then given by using the present and pre-existing experimental results. In addition, the proton widths of the first and second excited states of 12N are derived to be 0.91 \u00b1 0.29 and 99 \u00b1 20 keV from the neutron ANCs of 12B and used to compute the contribution from the first two resonances of 12N, respectively. We have also calculated the contribution from the interference effect between the direct capture and the second resonance. \u00a9 2007 IOP Publishing Ltd.",
        "keywords": [
            "reaction rate",
            "excited states"
        ],
        "authors": [
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Journal of Physics G: Nuclear and Particle Physics",
        "year": 2007
    },
    "fvkjZOXM": {
        "id": "fvkjZOXM",
        "title": "The 8Li(d, p)9Li reaction and astrophysical 8B(p, \u03b3)9C reaction rate",
        "abstract": "Angular distribution of the Li8 (d, p)9 Lig.s. reaction at Ecm = 7.8 MeV was measured in inverse kinematics. The square of asymptotic normalization coefficient (ANC) for the virtual decay 9Li \u2192 8Li + n was derived to be 1.33 \u00b1 0.33 fm-1 through distorted wave Born approximation (DWBA) analysis, for the first time. According to charge symmetry, (ANC)2 for 9C \u2192 8B + p was then extracted to be 1.14 \u00b1 0.29 fm-1. We have deduced the astrophysical S-factors and reaction rates for direct capture in 8B (p, \u03b3)9C at energies of astrophysical relevance using the ANC for 9C \u2192 8B + p extracted from the mirror system. \u00a9 2005 Elsevier B.V. All rights reserved.",
        "keywords": [
            "8B(p",
            " \u03b3)",
            " E = low",
            "Deduced astrophysical S-factor",
            "Deduced asymptotic normalization coefficient",
            "Measured \u03c3(\u03b8)",
            " DWBA analysis",
            "Mirror systems",
            "Nuclear reactions 2H(8Li",
            " 9Li)",
            " Ecm=7.8MeV"
        ],
        "authors": [
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yun Lu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Nuclear Physics A",
        "year": 2005
    },
    "3sQcCBZg": {
        "id": "3sQcCBZg",
        "title": "Production of Intense Radioactive Beams Using Low Energy Protons",
        "abstract": "An approach for the production of intense (-108ions/s) radioactive ion beams, which differs from the standard ISOL (Isotope Separation On-Line) technique, has been demonstrated successfully using 11C at the TRIUMF laboratory of Canada. By using this approach, the low energy (13MeV) protons can be utilized to produce a range of radioisotopes of interest to the nuclear astrophysics research programs.",
        "keywords": [
            "beam intensity",
            "radioactive ion beam",
            "projectile fragmentation",
            "isotope separation on line"
        ],
        "authors": [
            {
                "name": "GUO Bing",
                "org": "China Institute of Atomic Energy, Depeartment of Nuclear Physics, Beijing , China"
            },
            {
                "name": "LIU Wei-Ping",
                "org": "TRIUMF Vancouver B.C.;TRIUMF, Vancouver, B.C., CANADA, V6T 2A3"
            }
        ],
        "venue": "High Energy Physics and Nuclear Physics",
        "year": 2006
    },
    "wPHLxY1A": {
        "id": "wPHLxY1A",
        "title": "Excited States in18Ne Studied via17F +p",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jin Sunjun",
                "org": ""
            },
            {
                "name": "Wang You-Bao",
                "org": ""
            },
            {
                "name": "Wang Bao-Xiang",
                "org": ""
            },
            {
                "name": "Bai Xi-Xiang",
                "org": ""
            },
            {
                "name": "Fang Xiao",
                "org": ""
            },
            {
                "name": "Guo Bing",
                "org": ""
            },
            {
                "name": "Li Er-Tao",
                "org": ""
            },
            {
                "name": "Li Yun-Ju",
                "org": ""
            },
            {
                "name": "Li Zhi-Hong",
                "org": ""
            },
            {
                "name": "Lian Gang",
                "org": ""
            },
            {
                "name": "Su Jun",
                "org": ""
            },
            {
                "name": "Yan Sheng-Quan",
                "org": ""
            },
            {
                "name": "Zeng Sheng",
                "org": ""
            },
            {
                "name": "Yao Ze-En",
                "org": ""
            },
            {
                "name": "Liu Wei-Ping",
                "org": ""
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2010
    },
    "rjpSiM32": {
        "id": "rjpSiM32",
        "title": "Simulation and analysis of 13 N+p elastic resonance scattering",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "youbao wang",
                "org": ""
            },
            {
                "name": "xing qin",
                "org": ""
            },
            {
                "name": "baoxiang wang",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "zhihong li",
                "org": ""
            },
            {
                "name": "xixiang bai",
                "org": ""
            },
            {
                "name": "gang lian",
                "org": ""
            },
            {
                "name": "bing guo",
                "org": ""
            },
            {
                "name": "sheng zeng",
                "org": ""
            },
            {
                "name": "jun su",
                "org": ""
            },
            {
                "name": "yunju li",
                "org": ""
            },
            {
                "name": "chao jiang",
                "org": ""
            }
        ],
        "venue": "Chinese Physics C",
        "year": 2009
    },
    "ZwQyPVRk": {
        "id": "ZwQyPVRk",
        "title": "Setup for resonance scattering reactions with thick target",
        "abstract": "A setup aiming to measure the resonance scattering reactions with radioactive ion beams in inverse kinematics is installed on the secondary beam line at HI-13 TANDEM laboratory. The setup consists of a beam-monitoring time of flight system, and a \u0394E-E telescope based on large-area Double-Sided Silicon Strip Detector (DSSSD). The thick-target method for excitation function of proton resonance scattering is checked with a 57.0 MeV 17F secondary beam on a 7.66 mg/cm2 thick (CH2)n target.",
        "keywords": [
            "Double-sided silicon strip detector",
            "Elastic resonance scattering reaction",
            "Secondary radioactive ion beam",
            "Thick-target method"
        ],
        "authors": [
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "LiYang Jiang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Kao Neng Wu Li Yu Ho Wu Li/High Energy Physics and Nuclear Physics",
        "year": 2006
    },
    "ePOkBJzg": {
        "id": "ePOkBJzg",
        "title": "Astrophysical reaction rates of the 8Li(p, \u03b3) 9Be g.s. direct capture reaction",
        "abstract": "Based on the angular distribution of the 8Li(d,n) 9Be g.s. reaction at E c.m. \u2264 8.0 MeV and distorted wave Born approximation analysis, the single particle spectroscopic factor S 1,3/2 for the ground state of 9Be \u2264 8Li\u2297p is derived to be 0.64 \u00b1 0.21. In addition, we deduce the astrophysical S-factors and rates of the 8Li(p,\u03b3) 9Be g.s. direct capture reaction at energies of astrophysical interests. \u00a9 2005 Chinese Physical Society and IOP Publishing Ltd.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2006
    },
    "MwuBzdoQ": {
        "id": "MwuBzdoQ",
        "title": "Levels in13N examined by12C+p elastic resonance scattering with thick target",
        "abstract": "The elastic resonance scattering of 12C+p has been studied in inverse kinematics via a novel thick target method at GIRAFFE facility of HI-13 tandem accelerator laboratory, Beijing. The recoil protons were measured by a AE-E counter telescope based on a large area double-sided silicon strip detector at laboratory angles around \u03b8o = 15\u00b0. The excitation function for 12C(p,p) elastic scattering has been obtained over a wide energy range of Ec.m.=0.31-3.45 MeV, which was explained quite well by the R-matrix calculation with known resonance parameters of the first three levels in 13N nucleus. Thus it is demonstrated that the present setup can be directly applied to the study of elastic resonance scattering with secondary radioactive beams.",
        "keywords": [
            "Elastic resonance scattering",
            "Excitation function",
            "Thick-target method"
        ],
        "authors": [
            {
                "name": "Xing Qin",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Chao Jiang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "YunJu Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Chinese Physics C",
        "year": 2008
    },
    "m5NveisO": {
        "id": "m5NveisO",
        "title": "Calculation of astrophysical reaction rate of 82 Ge(n,?) 83 Ge",
        "abstract": "",
        "keywords": [
            "reaction rate"
        ],
        "authors": [
            {
                "name": "mian wang",
                "org": ""
            },
            {
                "name": "yongshou chen",
                "org": ""
            },
            {
                "name": "zhihong li",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "nengchuan shu",
                "org": ""
            }
        ],
        "venue": "Chinese Physics C",
        "year": 2009
    },
    "g1QLFh6j": {
        "id": "g1QLFh6j",
        "title": "New determination of the spectroscopic factor of $^7$Be ground state and the $^6$Li($p,\\gamma$)$^7$Be astrophysical S(E) factors.",
        "abstract": "The `lithium problemu0027 in Big Bang Nucleosynthesis (BBN) has recently focused on the reactions involving $^7$Be. The $^6$Li($p, gamma$)$^7$Be reaction can provide us not only the information for destroying $^6$Li but also the information for producing $^7$Be. In the present work, the proton spectroscopic factor in $^7$Be was extracted to be 0.70 $pm$ 0.17 from the angular distribution of $^7$Be($d$, $^3$He)$^6$Li at $E_mathrm{c.m.}$ = 6.7 MeV. The value was then used to compute the direct component of the astrophysical $^6$Li($p, gamma$)$^7$Be$_mathrm{g.s.}$ S(E) factors and determine the resonance parameters from the total S(E) factors.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhihong Li",
                "org": ""
            },
            {
                "name": "Er-Tao Li",
                "org": ""
            },
            {
                "name": "Jun Su",
                "org": ""
            },
            {
                "name": "Y. J. Li",
                "org": ""
            },
            {
                "name": "Youbao Wang",
                "org": ""
            },
            {
                "name": "Shengquan Yan",
                "org": ""
            },
            {
                "name": "B. Guo",
                "org": ""
            },
            {
                "name": "Ding Nan",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            }
        ],
        "venue": "arXiv: Nuclear Experiment",
        "year": 2018
    },
    "AD8yvo1l": {
        "id": "AD8yvo1l",
        "title": "Nuclear Astrophysics Experiments at CIAE",
        "abstract": "",
        "keywords": [
            "nuclear astrophysics",
            "reaction rate",
            "inverse kinematics",
            "ion beam",
            "cross section"
        ],
        "authors": [
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "zhihong li",
                "org": ""
            },
            {
                "name": "xixiang bai",
                "org": ""
            },
            {
                "name": "gang lian",
                "org": ""
            },
            {
                "name": "bing guo",
                "org": ""
            },
            {
                "name": "sheng zeng",
                "org": ""
            },
            {
                "name": "shengquan yan",
                "org": ""
            },
            {
                "name": "baoxiang wang",
                "org": ""
            },
            {
                "name": "nengchuan shu",
                "org": ""
            },
            {
                "name": "kaisu wu",
                "org": ""
            },
            {
                "name": "yongshou chen",
                "org": ""
            }
        ],
        "venue": "Nuclear Physics",
        "year": 2005
    },
    "Hm6swRnQ": {
        "id": "Hm6swRnQ",
        "title": "Empirical formula for ${\\boldsymbol \\beta}^ \\bf{-}$-decay half-lives of r-process nuclei",
        "abstract": "Experimental data of \u03b2 \u2212-decay half-lives of nuclei with atomic number between 20 and 190 are investigated. A systematic formula has been proposed to calculate \u03b2 \u2212-decay half-lives of neutron-rich nuclei, with a particular consideration on shell and pair effects, the decay energy Q as well as the nucleon numbers (Z, N). Although the formula has relatively few parameters, it reproduces the experimental \u2014decay half-lives of neutron-rich nuclei very well. The predicted half-lives for the r-process relevant nuclei obtained with the current formula serve as reliable input in the r-process model calculations.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhou Yong",
                "org": ""
            },
            {
                "name": "Li Zhihong",
                "org": ""
            },
            {
                "name": "Wang You-Bao",
                "org": ""
            },
            {
                "name": "Chen Yong-Shou",
                "org": ""
            },
            {
                "name": "Guo Bing",
                "org": ""
            },
            {
                "name": "Su Jun",
                "org": ""
            },
            {
                "name": "Li Yun-Ju",
                "org": ""
            },
            {
                "name": "Yan ShengQuan",
                "org": ""
            },
            {
                "name": "Li XinYue",
                "org": ""
            },
            {
                "name": "Han ZhiYu",
                "org": ""
            },
            {
                "name": "Shen Yangping",
                "org": ""
            },
            {
                "name": "Gan Lin",
                "org": ""
            },
            {
                "name": "Zeng Sheng",
                "org": ""
            },
            {
                "name": "Lian Gang",
                "org": ""
            },
            {
                "name": "Liu Wei-Ping",
                "org": ""
            }
        ],
        "venue": "Science China-physics Mechanics & Astronomy",
        "year": 2017
    },
    "uWEBPyVv": {
        "id": "uWEBPyVv",
        "title": "Levels in 13N examined by 12C+p elastic resonance scattering with thick target",
        "abstract": "The elastic resonance scattering of 12C+p has been studied in inverse kinematics via a novel thick target method at GIRAFFE facility of HI-13 tandem accelerator laboratory, Beijing. The recoil protons were measured by a \u25b3E-E counter telescope based on a large area double-sided silicon strip detector at laboratory angles around \u03b80 = 15\u00b0. The excitation function for 12C(p,p) elastic scattering has been obtained over a wide energy range of Ec.m.=0.31\u20143.45 MeV, which was explained quite well by the R-matrix calculation with known resonance parameters of the first three levels in 13N nucleus. Thus it is demonstrated that the present setup can be directly applied to the study of elastic resonance scattering with secondary radioactive beams.",
        "keywords": [
            "excitation function",
            "elastic resonance scattering",
            "thick-target method",
            "elastic scattering",
            "inverse kinematics"
        ],
        "authors": [
            {
                "name": "QIN Xing",
                "org": ""
            },
            {
                "name": "WANG You-Bao",
                "org": ""
            },
            {
                "name": "BAI Xi-Xiang",
                "org": ""
            },
            {
                "name": "GUO Bing",
                "org": ""
            },
            {
                "name": "JIANG Chao",
                "org": ""
            },
            {
                "name": "LI Yun-Ju",
                "org": ""
            },
            {
                "name": "LI Zhi-Hong",
                "org": ""
            },
            {
                "name": "LIAN Gang",
                "org": ""
            },
            {
                "name": "SU Jun",
                "org": ""
            },
            {
                "name": "WANG Bao-Xiang",
                "org": ""
            },
            {
                "name": "ZENG Sheng",
                "org": ""
            },
            {
                "name": "LIU Wei-Ping",
                "org": ""
            }
        ],
        "venue": "Chinese Physics C",
        "year": 2008
    },
    "p0eDgd5E": {
        "id": "p0eDgd5E",
        "title": "Determination of the 12 C( p, \u03b3 ) 13 N reaction rates from the 12 C( 7 Li, 6 He) 13 N reaction",
        "abstract": "The angular distribution of the 12C(7Li,6He)13N reaction at E(7Li) = 44.0 MeV was measured at the HI-13 tandem accelerator of Beijing, China. The asymptotic normalization coefficient (ANC)\n of 13N \u2192 12C + p was derived to be (1.64 \u00b1 0.11) fm\u22121/2 through the distorted wave Born approximation (DWBA) analysis. The ANC was then used to deduce the astrophysical S(E) factors and reaction rates for the 12C(p, \u03b3)13N direct capture reaction at energies of astrophysical relevance.",
        "keywords": [
            "the 12C(7Li",
            "6He)13N reaction",
            " DWBA analysis",
            " asymptotic normalization coefficient",
            " astrophysical S(E)-factor"
        ],
        "authors": [
            {
                "name": "ZhiHong\u00a0Li",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "Jun\u00a0Su",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "Bing\u00a0Guo",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "ZhiChang\u00a0Li",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "XiXiang\u00a0Bai",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "JianCheng\u00a0Liu",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "YunJu\u00a0Li",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "ShengQuan\u00a0Yan",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "BaoXiang\u00a0Wang",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "YouBao\u00a0Wang",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "Gang\u00a0Lian",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "Sheng\u00a0Zeng",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "ErTao\u00a0Li",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "YongShou\u00a0Chen",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "NengChuan\u00a0Shu",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "QiWen\u00a0Fan",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "WeiPing\u00a0Liu",
                "org": "China Institute of Atomic Energy,Beijing,China"
            }
        ],
        "venue": "Science China Physics, Mechanics and Astronomy",
        "year": 2010
    },
    "LXnYO6k8": {
        "id": "LXnYO6k8",
        "title": "Upgrading the injector system of Beijing HI-13 tandem accelerator",
        "abstract": "Upgrade the injector system of the Beijing HI-13 tandem accelerator has been completed at CIAE. The new injector system includes two beamlines. The high voltage beamline is for normal operation and the platform voltage is upgraded from 150 kV to 300 kV for a superconducting linac booster. The high resolution achromatic beam line, which consists of an electrostatic analyzer and a magnetic analyzer, with mass resolution of over 380, is dedicated to an accelerator mass spectrometry (AMS).",
        "keywords": [
            "Accelerator Mass Spectrometry",
            "Energy achromatic System"
        ],
        "authors": [
            {
                "name": "YiWen Bao",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xialing Guan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yueming Hu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "ShengYong Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Qubo You",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Qinghua Huang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xiaofei Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Chaoxin Kan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Tao Yang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "HongSheng Fan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "BaoJun Yang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Dezhong Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bingfan Yang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shan Jiang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Ming He",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Renwei Hu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yin Ren",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "ZhengYu Ma",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xiuhua Zhang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Fang Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Qiuju Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Minglong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "He Jishu/Nuclear Techniques",
        "year": 2007
    },
    "YyJLj7Bi": {
        "id": "YyJLj7Bi",
        "title": "Indirect measurements of nuclear astrophysics reactions at CIAE",
        "abstract": "This paper described the nuclear astrophysical studies using the unstable ion beam facility GIRAFFE, by indirect measurements. We measured the angular distributions for some single proton or neutron transfer reactions, such as 7Be(d,n)8B, 11C(d,n)12N, 8Li(d,n)9Be, 8Li(d,p)9Li and 13N(d,n)14O in inverse kinematics, and derived the astrophysical S-factors or reaction rates of 7Be(p,\u03b3) 8B, 11C(p,\u03b3)12N, 8Li(n, \u03b3)9Li, 13N(p,\u03b3)14O by asymptotic normalization coefficient, spectroscopic factor, and R-matrix approach at astrophysically relevant energies. \u00a9 2006 American Institute of Physics.",
        "keywords": [
            "astrophysical s-factor",
            "indirect measurement",
            "reaction rate",
            "transfer reaction",
            "nuclear astrophysics",
            "inverse kinematics",
            "ion beam"
        ],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Nengchuan Shu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yongshou Chen",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "AIP Conference Proceedings",
        "year": 2006
    },
    "nZ2wPv3s": {
        "id": "nZ2wPv3s",
        "title": "Angular Distribution of the<sup>12</sup>C(<sup>6</sup>He,<sup>7</sup>Li)<sup>11</sup>B Reaction",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Li Er-Tao",
                "org": ""
            },
            {
                "name": "Li Zhi-Hong",
                "org": ""
            },
            {
                "name": "Li Yun-Ju",
                "org": ""
            },
            {
                "name": "Yan Sheng-Quan",
                "org": ""
            },
            {
                "name": "Bai Xi-Xiang",
                "org": ""
            },
            {
                "name": "Guo Bing",
                "org": ""
            },
            {
                "name": "Su Jun",
                "org": ""
            },
            {
                "name": "Wang Yo-Bao",
                "org": ""
            },
            {
                "name": "Wang Bao-Xiang",
                "org": ""
            },
            {
                "name": "Lian Gang",
                "org": ""
            },
            {
                "name": "Zeng Sheng",
                "org": ""
            },
            {
                "name": "Fang Xiao",
                "org": ""
            },
            {
                "name": "Zhao Wei-Juan",
                "org": ""
            },
            {
                "name": "Liu Wei-Ping",
                "org": ""
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2009
    },
    "8yy3SjAK": {
        "id": "8yy3SjAK",
        "title": "First observation of neutron\u2013proton halo structure for the 3.563 MeV 0 + state in 6 Li via 1 H( 6 He, 6 Li) n reaction",
        "abstract": "",
        "keywords": [
            "ground state",
            "excited states",
            "inverse kinematics"
        ],
        "authors": [
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "xixiang bai",
                "org": ""
            },
            {
                "name": "youbao wang",
                "org": ""
            },
            {
                "name": "gang lian",
                "org": ""
            },
            {
                "name": "zhichang li",
                "org": ""
            },
            {
                "name": "sheng zeng",
                "org": ""
            }
        ],
        "venue": "Physics Letters B",
        "year": 2002
    },
    "NFXbe6hA": {
        "id": "NFXbe6hA",
        "title": "Determination of the 25Mg(p, \u03b3)26Al resonance strength at E c.m.=58 keV via shell model calculation",
        "abstract": "The observation of 26Al is an useful tool for \u03b3-ray astronomy and in studies of galactic chemical evolution. The most likely mechanism for 26A1 nucleosynthesis is in the hydrogen burning MgAl cycle, and the 26A1 production reaction 25Mg(p, \u03b3)26Al at the important temperature range below T = 0.2 GK is still not well known. The spectroscopic factor of 58 keV resonance level in 26A1 is determined with shell model calculation and then used to deduce the resonance strength of the 25Mg(p, \u03b3)26Al reaction. The result provides a reference for the future 25Mg(p, \u03b3)26Al direct measurement at Jinping underground laboratory.",
        "keywords": [
            "\u03b3-ray astronomy",
            " astrophysical reaction rate",
            " spectroscopic factor",
            " resonance strength"
        ],
        "authors": [
            {
                "name": "ZhiHong Li",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "YunJu Li",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "ErTao Li",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "YouBao Wang",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "ShengQuan Yan",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "WeiPing Liu",
                "org": "China Institute of Atomic Energy, Beijing, China"
            }
        ],
        "venue": "Science China-physics Mechanics & Astronomy",
        "year": 2015
    },
    "6B9n4yu7": {
        "id": "6B9n4yu7",
        "title": "Efficiency calibration of neutron detectors with 252Cf spontaneous fission neutrons",
        "abstract": "The efficiency curves of several scintillation neutron detectors were experimentally calibrated with 252Cf spontaneous fission neutrons at the low energy range and theoretically calculated with a code NEFF4. The relative efficiency curves obtained with experimental calibrations were normalized and connected to the calculations. The calculated efficiency curves were corrected according to the trends of the experimental points near the thresholds. This paper mainly described the technique of the experimental calibrations.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "AnLi Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xiaozhong Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yuan Yuan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Yuanzineng Kexue Jishu/Atomic Energy Science and Technology",
        "year": 1994
    },
    "TGUhbtsu": {
        "id": "TGUhbtsu",
        "title": "Astrophysical Reaction Rates of the 8Li(p,gamma)9Beg.s. Direct Capture Reaction",
        "abstract": "",
        "keywords": [
            "ground state",
            "reaction rate"
        ],
        "authors": [
            {
                "name": "jun su",
                "org": ""
            },
            {
                "name": "zhihong li",
                "org": ""
            },
            {
                "name": "bing guo",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "xixiang bai",
                "org": ""
            },
            {
                "name": "sheng zeng",
                "org": ""
            },
            {
                "name": "gang lian",
                "org": ""
            },
            {
                "name": "shengquan yan",
                "org": ""
            },
            {
                "name": "baoxiang wang",
                "org": ""
            },
            {
                "name": "youbao wang",
                "org": ""
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2006
    },
    "UUwwVacB": {
        "id": "UUwwVacB",
        "title": "BRIF and CARIF progress",
        "abstract": "China Institute of Atomic Energy (CIAE) is currently constructing Beijing rare ion beam facility (BRIF) and is proposing China\n advanced rare ion beam facility (CARIF). This paper is aiming at introducing the progress of BRIF project and the conceptual\n design CARIF. The ISOL type facility BRIF under construction is composed of a 100 MeV 300 \u03bcA proton cyclotron, an ISOL with\n mass resolution of 20000, and a super-conducting LINAC of 2 MeV/q, and will be commissioned in 2013. CARIF facility proposed\n is planned to use both ISOL and PF techniques. It is based on a China advanced research reactor CARR that was critical, with\n ISOL separation of fission fragment, post acceleration to 150 MeV/u, and fragmentation of neutron-rich fission fragment beam\n like 132Sn. Such unique combination will allow CARIF to deliver beam intensity better than the best world facilities by more than\n one order of magnitude.",
        "keywords": [
            "pf",
            "rare ion beam",
            "isol"
        ],
        "authors": [
            {
                "name": "weiping liu",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "zhihong li",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "xixiang bai",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "youbao wang",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "bing guo",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "chaohua peng",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "yi yang",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "jun su",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "baoqun cui",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "shuhua zhou",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "shengyun zhu",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "haihong xia",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "xialing guan",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "sheng zeng",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "huanqiao zhang",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "yongshou chen",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "hongqing tang",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "li huang",
                "org": "China Institute of Atomic Energy,Beijing,China"
            },
            {
                "name": "beiyuan feng",
                "org": "China Institute of Atomic Energy,Beijing,China"
            }
        ],
        "venue": "\u4e2d\u56fd\u79d1\u5b66:\u7269\u7406\u5b66 \u529b\u5b66 \u5929\u6587\u5b66(\u82f1\u6587\u7248)",
        "year": 2011
    },
    "1XbW1Nzj": {
        "id": "1XbW1Nzj",
        "title": "The 11C(p,\u03b3)12N reaction rate and the conversion of 3He into CNO",
        "abstract": "The reaction sequence of 3He(\u03b1,\u03b3)7Be (\u03b1,\u03b3)11C(p,\u03b3)12N to CNO could be an alterative way of 3\u03b1 \u219212C to convert 3He into CNO. It may become important in some specific environments, such as in a very massive star with low metallicity. Whether it is significant depends on the reactions involved, one of the important reactions is the 11C p-capture competing with its \u03b2+ decay. The S factor for the 11C (p,\u03b3)12N direct capture was obtained in our previous work. This work is to update the reaction rate by adding uncertainty and fitting with the Thielemann format. With the new rate, nucleosynthesis simulations are performed to study the bridge of the p-p chains to CNO through the above sequence. \u00a9 2005 Elsevier B.V. All rights reserved.",
        "keywords": [
            "reaction rate"
        ],
        "authors": [
            {
                "name": "Nengchuan Shu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yongshou Chen",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Kaisu Wu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Nuclear Physics A",
        "year": 2005
    },
    "aRdGcLeP": {
        "id": "aRdGcLeP",
        "title": "The 95Zr(n, \u03b3)96Zr Cross Section from the Surrogate Ratio Method and Its Effect on s-process Nucleosynthesis",
        "abstract": "The 95Zr(n,gamma)96Zr reaction cross section is crucial in the modelling of s-process nucleosynthesis in asymptotic giant branch stars because it controls the operation of the branching point at the unstable 95Zr and the subsequent production of 96Zr. We have carried out the measurement of the 94Zr(18O,16O) and 90Zr(18O,16O) reactions and obtained the gamma-decay probability ratio of 96Zr* and 92Zr* to determine the 95Zr(n,gamma)96Zr reaction cross sections with the surrogate ratio method. Our deduced maxwellian-averaged cross section of 66+-16 mb at 30 keV is close to the value recommended by Bao et al. (2000), but 30% and more than a factor of two larger than the values proposed by Toukan u0026 Kappeler (1990) and Lugaro et al. (2014), respectively, and routinely used in s-process models. We tested the new rate in stellar models with masses between 2 and 6 Msun and metallicities 0.014 and 0.03. The largest changes - up 80% variations in 96Zr - are seen in models of mass 3-4 Msun, where the 22Ne neutron source is mildly activated. The new rate can still provide a match to data from meteoritic stardust silicon carbide grains, provided the maximum mass of the parent stars is below 4 Msun, for a metallicity of 0.03.",
        "keywords": "",
        "authors": [
            {
                "name": "S. Q. Yan",
                "org": "China Institute of Atomic Energy, P.O. Box 275(10), Beijing 102413, P. R. China"
            },
            {
                "name": "Z. H. Li",
                "org": "China Institute of Atomic Energy, P.O. Box 275(10), Beijing 102413, P. R. China"
            },
            {
                "name": "Y. B. Wang",
                "org": "China Institute of Atomic Energy, P.O. Box 275(10), Beijing 102413, P. R. China"
            },
            {
                "name": "K. Nishio",
                "org": "Japan Atomic Energy Agency, Tokai, Naka, Ibaraki 319-1195, Japan"
            },
            {
                "name": "M. Lugaro",
                "org": "Konkoly Observatory, Research Centre for Astronomy and Earth Sciences, Hungarian Academy of Sciences, 1121 Budapest, Hungary"
            },
            {
                "name": "M. Lugaro",
                "org": "Konkoly Observatory, Research Centre for Astronomy and Earth Sciences, Hungarian Academy of Sciences, 1121 Budapest, Hungary"
            },
            {
                "name": "A. I. Karakas",
                "org": "Monash Centre for Astrophysics, School of Physics and Astronomy, Monash University, Clayton, VIC 3800, Australia"
            },
            {
                "name": "H. Makii",
                "org": "Japan Atomic Energy Agency, Tokai, Naka, Ibaraki 319-1195, Japan"
            },
            {
                "name": "P. Mohr",
                "org": "Institute for Nuclear Research (ATOMKI), H-4001 Debrecen, Hungary"
            },
            {
                "name": "J. Su",
                "org": "China Institute of Atomic Energy, P.O. Box 275(10), Beijing 102413, P. R. China"
            },
            {
                "name": "Y. J. Li",
                "org": "China Institute of Atomic Energy, P.O. Box 275(10), Beijing 102413, P. R. China"
            },
            {
                "name": "I. Nishinaka",
                "org": "Japan Atomic Energy Agency, Tokai, Naka, Ibaraki 319-1195, Japan"
            },
            {
                "name": "K. Hirose",
                "org": "Japan Atomic Energy Agency, Tokai, Naka, Ibaraki 319-1195, Japan"
            },
            {
                "name": "Y. L. Han",
                "org": "China Institute of Atomic Energy, P.O. Box 275(10), Beijing 102413, P. R. China"
            },
            {
                "name": "R. Orlandi",
                "org": "Japan Atomic Energy Agency, Tokai, Naka, Ibaraki 319-1195, Japan"
            },
            {
                "name": "Y. P. Shen",
                "org": "China Institute of Atomic Energy, P.O. Box 275(10), Beijing 102413, P. R. China"
            },
            {
                "name": "B. Guo",
                "org": "China Institute of Atomic Energy, P.O. Box 275(10), Beijing 102413, P. R. China"
            },
            {
                "name": "S. Zeng",
                "org": "China Institute of Atomic Energy, P.O. Box 275(10), Beijing 102413, P. R. China"
            },
            {
                "name": "G. Lian",
                "org": "China Institute of Atomic Energy, P.O. Box 275(10), Beijing 102413, P. R. China"
            },
            {
                "name": "Y. S. Chen",
                "org": "China Institute of Atomic Energy, P.O. Box 275(10), Beijing 102413, P. R. China"
            },
            {
                "name": "W. P. Liu",
                "org": "China Institute of Atomic Energy, P.O. Box 275(10), Beijing 102413, P. R. China"
            }
        ],
        "venue": "The Astrophysical Journal",
        "year": 2017
    },
    "4pIgGnfW": {
        "id": "4pIgGnfW",
        "title": "Simulation and analysis of \uff5e(13)N+p elastic resonance scattering",
        "abstract": "The 13N+p elastic resonance scattering has been studied at the secondary radioactive beam facility of CIAE in inverse kinematics via a thick-target method. The excitation function for the 13N(p,p) scattering was obtained in the energy interval of Ecm \u22480.5\u20143.2 MeV with a 13N secondary beam of (47.8\u00b11.5) MeV. Careful analysis of the secondary beam components and extensive Monte-Carlo simulations enable the resolution of the experimental proton spectra. The resonance parameters for five low-lying levels in 14O were deduced by R-matrix fitting calculations with MULTI7 and SAMMY-M6-BETA. The present results show general agreement with those from a recent similar work, and thus confirm the observation of a new 0- level at 5.7 MeV in 14O with an improved width of 400(45) keV.",
        "keywords": [
            "excitation function",
            "elastic resonance scattering",
            "radioactive secondary beam",
            "thick-target method"
        ],
        "authors": [
            {
                "name": "WANG You-Bao",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy%%#CIAE%%#, Beijing , China"
            },
            {
                "name": "QIN Xing",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy%%#CIAE%%#, Beijing , China"
            },
            {
                "name": "WANG Bao-Xiang",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy%%#CIAE%%#, Beijing , China"
            },
            {
                "name": "LIU Wei-Ping",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy%%#CIAE%%#, Beijing , China"
            },
            {
                "name": "LI Zhi-Hong",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy%%#CIAE%%#, Beijing , China"
            },
            {
                "name": "BAI Xi-Xiang",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy%%#CIAE%%#, Beijing , China"
            },
            {
                "name": "LIAN Gang",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy%%#CIAE%%#, Beijing , China"
            },
            {
                "name": "GUO Bing",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy%%#CIAE%%#, Beijing , China"
            },
            {
                "name": "ZENG Sheng",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy%%#CIAE%%#, Beijing , China"
            },
            {
                "name": "SU Jun",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy%%#CIAE%%#, Beijing , China"
            },
            {
                "name": "LI Yun-Ju",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy%%#CIAE%%#, Beijing , China"
            },
            {
                "name": "JIANG Chao",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy%%#CIAE%%#, Beijing , China"
            }
        ],
        "venue": "Chinese Physics C",
        "year": 2009
    },
    "29qIMoqZ": {
        "id": "29qIMoqZ",
        "title": "Asymptotic Normalization Coefficient of 27P --> 26Si + p and Radius of 27P Halo",
        "abstract": "",
        "keywords": [
            "ground state"
        ],
        "authors": [
            {
                "name": "bing guo",
                "org": ""
            },
            {
                "name": "zhihong li",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "xixiang bai",
                "org": ""
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2006
    },
    "6SL2ltvZ": {
        "id": "6SL2ltvZ",
        "title": "Angular Distribution for<sup>7</sup>Be(d, n)<sup>8</sup>B Reaction at<i>E</i><sub>c.m.</sub>= 8.3 MeV and the Astrophysical<i>S</i><sub>17</sub>(0) Factor for<sup>7</sup>Be(p, \u03b3)<sup>8</sup>B Reaction",
        "abstract": "",
        "keywords": [
            "cross section"
        ],
        "authors": [
            {
                "name": "You-bao Wang",
                "org": ""
            },
            {
                "name": "Wei-ping Liu",
                "org": ""
            },
            {
                "name": "Xi-xiang Bai",
                "org": ""
            },
            {
                "name": "Zhi-chang Li",
                "org": ""
            },
            {
                "name": "An-li Li",
                "org": ""
            },
            {
                "name": "Shu-hua Zhou",
                "org": ""
            },
            {
                "name": "Xiao-feng Zhu",
                "org": ""
            },
            {
                "name": "Xiao-mei Li",
                "org": ""
            },
            {
                "name": "Gao-kui He",
                "org": ""
            },
            {
                "name": "Gang Guo",
                "org": ""
            },
            {
                "name": "Gang Lian",
                "org": ""
            },
            {
                "name": "Xiao-dong Tang",
                "org": "texas a m university"
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 1999
    },
    "6R7ic3Kk": {
        "id": "6R7ic3Kk",
        "title": "Alpha decay half-life of 147Sm in metal samarium and Sm2O3",
        "abstract": "In order to investigate the possible influence of metallic environment on the alpha decay process, we have measured the 147Sm activities in the hosts of metal samarium and Sm2O3. The 147Sm half-life was found to be (1.06\u00b10.01)\u00d71011 y in metal samarium and (1.07\u00b10.01)\u00d71011 y in Sm2O3, respectively. No significant change has been observed within the experimental uncertainty. The absolute half-life presented here is consistent with the recommended value. \u00a9 2010 SIF, Springer-Verlag Berlin Heidelberg.",
        "keywords": [],
        "authors": [
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "L. C. Zhu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "YunJu Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Ertao Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "SunJun Jin",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xin Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Qiwen Fan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "JiLong Zhang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "X. Y. Jiang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "J. X. Lu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xiaofei Lan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "XiuZhang Tang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "European Physical Journal A",
        "year": 2010
    },
    "fUavc7M9": {
        "id": "fUavc7M9",
        "title": "Determination of the 12C(p, \u03b3) 13N reaction rates from the 12C(7Li, 6He) 13N reaction",
        "abstract": "The angular distribution of the 12C(7Li, 6He) 13N reaction at E(7Li) = 44.0 MeV was measured at the HI-13 tandem accelerator of Beijing, China. The asymptotic normalization coefficient (ANC) of 13N-\u2192 12C + p was derived to be (1.64 \u00b1 0.11) fm -1'2 through the distorted wave Born approximation (DWBA) analysis. The ANC was then used to deduce the astrophysical S(E) factors and reaction rates for the 12C(p, \u03b3) 13N direct capture reaction at energies of astrophysical relevance. \u00a9 Science China Press and Springer-Verlag Berlin Heidelberg 2010.",
        "keywords": [
            "Astrophysical S(E)-factor",
            "Asymptotic normalization coefficient",
            "DWBA analysis",
            "The 12C(7Li",
            " 6He) 13N reaction"
        ],
        "authors": [
            {
                "name": "Li Zhihong",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Su Jun",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Guo Bing",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Li Zhichang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bai Xixiang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Liu Jiancheng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Li Yunju",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yan Shengquan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Wang Baoxiang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Wang Youbao",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Lian Gang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zeng Sheng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Li Ertao",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Chen Yongshou",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shu Nengchuan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Fan Qiwen",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Liu Weiping",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Science China: Physics, Mechanics and Astronomy",
        "year": 2010
    },
    "Wy37sELn": {
        "id": "Wy37sELn",
        "title": "Extracting spectroscopic factors from elastic transfer reactions",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Y. J. Li",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "B. Guo",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Ding Nan",
                "org": "China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Er-Tao Li",
                "org": "College of Physics and Energy, Shenzhen University, Shenzhen, China"
            },
            {
                "name": "L. Gan",
                "org": "College of Physics and Energy, Shenzhen University, Shenzhen, China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy, Beijing, China"
            }
        ],
        "venue": "Science China-physics Mechanics & Astronomy",
        "year": 2019
    },
    "eYdPL7B7": {
        "id": "eYdPL7B7",
        "title": "Measurement of the 52Fe mass via the precise proton-decay energy of 53Com",
        "abstract": "The proton decay of  53 Co  m  (3174.1 keV; 19/2 \u2212 ) was investigated via the fragmentation of a  58 Ni primary beam. The proton-decay energy was determined with an improved precision to be 1558(8) keV. With this new result and the mass of  53 Co  m  , the  52 Fe mass excess was derived to be \u221248330(8) keV, which is in good agreement with the AME12 value. A new recommended value of \u221248331.6(49) keV is given.",
        "keywords": "",
        "authors": [
            {
                "name": "Y. P. Shen",
                "org": "China Institute of Atomic Energy, P. O. Box 275(1), Beijing 102413, China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy, P. O. Box 275(1), Beijing 102413, China"
            },
            {
                "name": "J. Su",
                "org": "China Institute of Atomic Energy, P. O. Box 275(1), Beijing 102413, China"
            },
            {
                "name": "N. T. Zhang",
                "org": "Key Laboratory of High Precision Nuclear Spectroscopy and Center for Nuclear Matter Science, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "Long Jing",
                "org": "China Institute of Atomic Energy, P. O. Box 275(1), Beijing 102413, China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy, P. O. Box 275(1), Beijing 102413, China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy, P. O. Box 275(1), Beijing 102413, China"
            },
            {
                "name": "B. Guo",
                "org": "China Institute of Atomic Energy, P. O. Box 275(1), Beijing 102413, China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy, P. O. Box 275(1), Beijing 102413, China"
            },
            {
                "name": "Y. J. Li",
                "org": "China Institute of Atomic Energy, P. O. Box 275(1), Beijing 102413, China"
            },
            {
                "name": "S. Zeng",
                "org": "China Institute of Atomic Energy, P. O. Box 275(1), Beijing 102413, China"
            },
            {
                "name": "G. Lian",
                "org": "China Institute of Atomic Energy, P. O. Box 275(1), Beijing 102413, China"
            },
            {
                "name": "Xianchao Du",
                "org": ""
            },
            {
                "name": "L. Gan",
                "org": "China Institute of Atomic Energy, P. O. Box 275(1), Beijing 102413, China"
            },
            {
                "name": "X.D. Bai",
                "org": "China Institute of Atomic Energy, P. O. Box 275(1), Beijing 102413, China"
            },
            {
                "name": "J.Z. Wang",
                "org": ""
            },
            {
                "name": "Yu-Hu Zhang",
                "org": "Key Laboratory of High Precision Nuclear Spectroscopy and Center for Nuclear Matter Science, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "Xiao-Hong Zhou",
                "org": "Key Laboratory of High Precision Nuclear Spectroscopy and Center for Nuclear Matter Science, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "Xiaodong Tang",
                "org": "Key Laboratory of High Precision Nuclear Spectroscopy and Center for Nuclear Matter Science, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "J.J. He",
                "org": ""
            },
            {
                "name": "Yan-Yun Yang",
                "org": "Key Laboratory of High Precision Nuclear Spectroscopy and Center for Nuclear Matter Science, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "S. L. Jin",
                "org": "Key Laboratory of High Precision Nuclear Spectroscopy and Center for Nuclear Matter Science, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "P. Ma",
                "org": ""
            },
            {
                "name": "J.M. Ma",
                "org": "Key Laboratory of High Precision Nuclear Spectroscopy and Center for Nuclear Matter Science, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "Mei-Rong Huang",
                "org": "Key Laboratory of High Precision Nuclear Spectroscopy and Center for Nuclear Matter Science, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "Zhen Bai",
                "org": "Key Laboratory of High Precision Nuclear Spectroscopy and Center for Nuclear Matter Science, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "Yuanjie Zhou",
                "org": "Key Laboratory of High Precision Nuclear Spectroscopy and Center for Nuclear Matter Science, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "W. H. Ma",
                "org": "Key Laboratory of High Precision Nuclear Spectroscopy and Center for Nuclear Matter Science, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "Jun Hu",
                "org": "China Institute of Atomic Energy, P. O. Box 275(1), Beijing 102413, China"
            },
            {
                "name": "Shi-Wei Xu",
                "org": "Key Laboratory of High Precision Nuclear Spectroscopy and Center for Nuclear Matter Science, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "S. Ma",
                "org": "Key Laboratory of High Precision Nuclear Spectroscopy and Center for Nuclear Matter Science, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "Size Chen",
                "org": "Key Laboratory of High Precision Nuclear Spectroscopy and Center for Nuclear Matter Science, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "LiYong Zhang",
                "org": "Key Laboratory of High Precision Nuclear Spectroscopy and Center for Nuclear Matter Science, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "B. Ding",
                "org": "Key Laboratory of High Precision Nuclear Spectroscopy and Center for Nuclear Matter Science, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "Z. H. Li",
                "org": "School of Physics and State Key Laboratory of Nuclear Physics and Technology, Peking University, Beijing 100871, China"
            }
        ],
        "venue": "Physical Review C",
        "year": 2016
    },
    "m428HXYj": {
        "id": "m428HXYj",
        "title": "Angular distribution for the7Be(d, n)8B reaction at Ec.m. = 5.8 MeV and the S17(0) factor for the7Be(p, \ufffd\ufffd)8B reaction",
        "abstract": "The differential cross section for the 7Be(d, n)8B reaction at Ec.m. = 5.8 MeV has been measured using the 7Be beam generated by the radioactive nuclear beam facility at China Institute of Atomic Energy. The 8B ions were detected in full geometry with a two-dimensional position sensitive \ufffd\ufffdE-E counter telescope. The reaction cross section was determined to be 58 \ufffd\ufffd 8 mb. The angular distribution data were analyzed with the distorted-wave Born approximation calculation. The astrophysical S17(0) factor for the 7Be(p, \ufffd\ufffd)8B reaction was derived to be 27.4 \ufffd\ufffd 4.4 eV b through the asymptotic normalization constant extracted from the experimental data.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shuhua Zhou",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhanwen Ma",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhichang Li.",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "AnLi Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhongyu Ma",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "BaoQiu Chen",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xiaodong Tang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yinlu Han",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Qingbiao Shen",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 1996
    },
    "JkjOZqry": {
        "id": "JkjOZqry",
        "title": "The Beijing ISOL initial conceptual design report",
        "abstract": "",
        "keywords": [
            "reactor"
        ],
        "authors": [
            {
                "name": "baoqun cui",
                "org": ""
            },
            {
                "name": "yuan gao",
                "org": ""
            },
            {
                "name": "yucheng ge",
                "org": ""
            },
            {
                "name": "zhiyu guo",
                "org": ""
            },
            {
                "name": "zhihong li",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "shixiang peng",
                "org": ""
            },
            {
                "name": "zhaohua peng",
                "org": ""
            },
            {
                "name": "zhi wang",
                "org": ""
            },
            {
                "name": "sha yan",
                "org": ""
            },
            {
                "name": "yanlin ye",
                "org": ""
            },
            {
                "name": "sheng zeng",
                "org": ""
            },
            {
                "name": "guohui zhang",
                "org": ""
            },
            {
                "name": "feng zhu",
                "org": ""
            }
        ],
        "venue": "Nuclear Instruments & Methods in Physics Research Section B-beam Interactions With Materials and Atoms",
        "year": 2013
    },
    "Rq5m4GEj": {
        "id": "Rq5m4GEj",
        "title": "Indirect measurements of nuclear astrophysics reactions using unstable nuclear beams",
        "abstract": "This paper described the nuclear astrophysical studies using the unstable ion beam facility GIRAFFE, by indirect measurements. We measured the angular distributions for some single proton or neutron transfer reactions, such as 7 Be(d,n)8B, 11C(d,n)12N, 8Li(d,n)9Be, 8Li(d,p)9Li and 13N(d,n)14O in inverse kinematics, and derived the astrophysical S-factors or reaction rates of 7Be(p,\u03b3) 8B, 11C(p,\u03b3)12N, 8Li(n, \u03b3)9Li, 13N(p,\u03b3)14O by asymptotic normalization coefficient, spectroscopic factor, and R-matrix approach at astrophysically relevant energies. \u00a9 World Scientific Publishing Company.",
        "keywords": [
            "nuclear astrophysics",
            "inverse kinematics",
            "ion beam",
            "reaction rate"
        ],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Nengchuan Shu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yongshou Chen",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "International Journal of Modern Physics E",
        "year": 2006
    },
    "HAGIMUMI": {
        "id": "HAGIMUMI",
        "title": "Astrophysical rates for the 6He(p, \u03b3)7Li reaction",
        "abstract": "Angular distribution of the 6He(d,n)7Li reaction at Ec.m.=9.1 MeV is measured in inverse kinematics for the first time. The proton spectroscopic factors for the ground and first excited states of 7Li are derived by using the distorted wave Born approximation analysis. The astrophysical rates of 6He(p, \u03b3)7Li reaction are then deduced and fitted with an expression of REACLIB. \u00a9 2011 Chinese Physical Society and IOP Publishing Ltd.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Ertao Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "YunJu Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xiao Fang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "WeiJuan Zhao",
                "org": "Zhengzhou University(Zhengzhou University),Zhengzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2011
    },
    "9sbtkPOV": {
        "id": "9sbtkPOV",
        "title": "Search for the Halo Effect in the 1H(6He, 6Li)n Reaction",
        "abstract": "",
        "keywords": [
            "ground state",
            "excited states"
        ],
        "authors": [
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "xixiang bai",
                "org": ""
            },
            {
                "name": "youbao wang",
                "org": ""
            },
            {
                "name": "gang lian",
                "org": ""
            },
            {
                "name": "zhichang li",
                "org": ""
            },
            {
                "name": "qingbiao shen",
                "org": ""
            },
            {
                "name": "chengjian lin",
                "org": ""
            },
            {
                "name": "sheng zeng",
                "org": ""
            },
            {
                "name": "changbo fu",
                "org": ""
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2002
    },
    "nLpvBtS7": {
        "id": "nLpvBtS7",
        "title": "Excited States in<sup>18</sup>Ne Studied via<sup>17</sup>F +<i>p</i>",
        "abstract": "",
        "keywords": [
            "excited states"
        ],
        "authors": [
            {
                "name": "Jin Sun-Jun",
                "org": ""
            },
            {
                "name": "Wang You-Bao",
                "org": ""
            },
            {
                "name": "Wang Bao-Xiang",
                "org": ""
            },
            {
                "name": "Bai Xi-Xiang",
                "org": ""
            },
            {
                "name": "Fang Xiao",
                "org": ""
            },
            {
                "name": "Guo Bing",
                "org": ""
            },
            {
                "name": "Li Er-Tao",
                "org": ""
            },
            {
                "name": "Li Yun-Ju",
                "org": ""
            },
            {
                "name": "Li Zhi-Hong",
                "org": ""
            },
            {
                "name": "Lian Gang",
                "org": ""
            },
            {
                "name": "Su Jun",
                "org": ""
            },
            {
                "name": "Yan Sheng-Quan",
                "org": ""
            },
            {
                "name": "Zeng Sheng",
                "org": ""
            },
            {
                "name": "Yao Ze-En",
                "org": ""
            },
            {
                "name": "Liu Wei-Ping",
                "org": ""
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2010
    },
    "ix6HwdO9": {
        "id": "ix6HwdO9",
        "title": "Production of 10C secondary beam",
        "abstract": "A 10C beam with the energy of (55, 9 \u00b1 0.9) MeV was produced via the 1H(10B, 10C)n reaction on the secondary beam line of the HI-13 tandem accelerator at China Institute of Atomic Energy. The purity of the collimated 10C beam is more than 90% after the magnetic and velocity selection. The beam intensity is about 6 s-1\u00b7 pnA-1.",
        "keywords": [
            "Magnetic rigidity",
            "Secondary beam",
            "Wien filter"
        ],
        "authors": [
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Yuanzineng Kexue Jishu/Atomic Energy Science and Technology",
        "year": 2006
    },
    "i1R1WOUX": {
        "id": "i1R1WOUX",
        "title": "First observation of neutron-proton halo structure for the 3.563 MeV 0+ state in 6Li via 1H(6He, 6Li)n reaction",
        "abstract": "The angular distributions of the charge exchange reaction 1H(6He, 6Li)n were measured in reverse kinematics with a secondary 6He beam at the energy of 4.17 A MeV. The data were analyzed in the context of a microscopic calculation. It is shown that both the ground state of 6He and the second excited state of 6Li (3.563 MeV, 0+) have halo structure. \u00a9 2002 Elsevier Science B.V. All rights reserved.",
        "keywords": [
            "1H(6He",
            " 6Li)n reaction in inverse kinematics",
            "Angular distribution",
            "Microscopic optical potential",
            "Nucleon density distribution",
            "Proton-neutron halo structure"
        ],
        "authors": [
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhichang Li.",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics",
        "year": 2002
    },
    "YeYpgNxl": {
        "id": "YeYpgNxl",
        "title": "Determination of astrophysical 7Be(p, \u03b3)8B reaction rates from the 7Li(d, p)8Li reaction",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xianchao du",
                "org": ""
            },
            {
                "name": "bing guo",
                "org": ""
            },
            {
                "name": "zhihong li",
                "org": ""
            },
            {
                "name": "danyang pang",
                "org": "beihang university"
            },
            {
                "name": "ertao li",
                "org": "shenzhen university"
            },
            {
                "name": "weiping liu",
                "org": ""
            }
        ],
        "venue": "Science China-physics Mechanics & Astronomy",
        "year": 2015
    },
    "yo8m4Fvb": {
        "id": "yo8m4Fvb",
        "title": "New determination of astrophysical 14C(n, \u03b3)15C reaction rate from the spectroscopic factor of 15C",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "TianLi Ma",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Bing Guo",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "DanYang Pang",
                "org": "School of Physics and Nuclear Energy Engineering, Beihang University,Beijing,China"
            },
            {
                "name": "ZhiHong Li",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Yi Su",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "XinYue Li",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "YangPing Shen",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "YouBao Wang",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "YunJu Li",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Jun Su",
                "org": "College of Nuclear Science and Technology, Beijing Normal University, Beijing, China"
            },
            {
                "name": "ShengQuan Yan",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Sheng Zeng",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Gang Lian",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "Ding Nan",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy, Beijing, China"
            },
            {
                "name": "WeiPing Liu",
                "org": "Department of Nuclear Physics, China Institute of Atomic Energy, Beijing, China"
            }
        ],
        "venue": "Science China-physics Mechanics & Astronomy",
        "year": 2020
    },
    "LRKGuJpf": {
        "id": "LRKGuJpf",
        "title": "Determination of (p,\u03b3) reaction rates via transfer reactions of mirror nuclei",
        "abstract": "A method, neutron transfer reaction and charge symmetry of mirror nuclei, is used to study (p,\u03b3) reaction on proton-rich nuclei in this paper. The asymptotic normalization coefficients (ANCs) of virtual decays 9Li \u2192 8Li + n and 27Mg \u2192 26Mg + n were extracted from the angular distributions of the 8Li(d, p) 9Li and 26Mg(d, p)27Mg reactions, through distorted wave Born approximation (DWBA) analysis. The astrophysical S-factors and reaction rates of 8B(p, \u03b3)9C and 26Si(p, \u03b3)27P were then determined based on charge symmetry. \u00a9 2006 American Institute of Physics.",
        "keywords": [
            "anc",
            "mirror nuclei",
            "reaction rate",
            "s-factor"
        ],
        "authors": [
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yubo Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Nengchuan Shu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yongshou Chen",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "AIP Conference Proceedings",
        "year": 2006
    },
    "yJ4GN3Lx": {
        "id": "yJ4GN3Lx",
        "title": "Approaches in the experiment of nuclear reactions induced by low energy secondary beams",
        "abstract": "An experimental scheme was established for studying the inverse kinematic reactions induced by low-energy secondary radioactive nuclear beams which uses a serial measures such as strict collimation of the secondary beams, full solid angle detection of the reaction products with x-y position sensitive E-E counter telescope, and mixing trigger as well as pileup rejection to realize success fully the angular distribution measurement under the condition of low beam intensity.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhichang Li.",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shuhua Zhou",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "AnLi Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xiaofeng Zhu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhanwen Ma",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Yuanzineng Kexue Jishu/Atomic Energy Science and Technology",
        "year": 1999
    },
    "e4Rh7xsY": {
        "id": "e4Rh7xsY",
        "title": "Production of 11C and 17F secondary radioactive beams",
        "abstract": "THe 11C and 17F secondary beams were successfully tuned on the CIAE secondary radioactive beam line at the HI-13 tandem accelerator. The setting parameters of the secondary beam line and the beam quality for 11C and 17F were given, and a 11C beam was produced with intensity of 1.2\ufffd\ufffd105 particles/s and energy of 41\ufffd\ufffd1.0 MeV.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jiuchang Qin",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhichang Li.",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shuhua Zhou",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Junfeng Zhou",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "AnLi Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xialing Guan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xiaozhong Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Chinese Journal of Nuclear Physics",
        "year": 1994
    },
    "fDfJ4nrr": {
        "id": "fDfJ4nrr",
        "title": "New determination of the astrophysical 13C(p, \u03b3) 14N S(E) factors and reaction rates via the 13C( 7Li, 6He) 14N reaction",
        "abstract": "The 13C( 7Li, 6He) 14 N 0,1 reactions were measured at E ( 7Li) = 34 MeV with the Q3D magnetic spectrometer of the HI-13 tandem accelerator, and the first peaks of the angular distributions were obtained for the first time. The 14N 0,1 proton spectroscopic factors were extracted to be 0.67\u00b10.09 and 0.73\u00b10.10, respectively. Using the 13C(p, \u03b3) 14N direct capture S dc(E) factors derived by the spectroscopic factors, the direct measurement data for both 1 - and 0 - resonances were well fitted via updating the resonance parameters, and then the total astrophysical 13C(p, \u03b3) 14N S(E) factors and reaction rates were determined at stellar energies. The present work offers an independent examination to the existing results of the 13 C(p, \u03b3) 14N reaction. \u00a9 2012 SIF, Springer-Verlag Berlin Heidelberg.",
        "keywords": [
            "Angular Distribution",
            " Resonance Parameter",
            " Spectroscopic Factor",
            " Radiative Width",
            " Direct Capture"
        ],
        "authors": [
            {
                "name": "YunJu Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Ertao Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhichang Li.",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "JianCheng Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xin Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "SunJun Jin",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Liyong Zhang",
                "org": "Institute of Modern Physics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Modern Physics,Inst of Modern Physics),Lanzhou,China"
            },
            {
                "name": "Xian Yu",
                "org": "Institute of Modern Physics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Modern Physics,Inst of Modern Physics),Lanzhou,China"
            },
            {
                "name": "LiangXin Li",
                "org": "Institute of Modern Physics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Modern Physics,Inst of Modern Physics),Lanzhou,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Qiwen Fan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "European Physical Journal A",
        "year": 2012
    },
    "UnqAa6wV": {
        "id": "UnqAa6wV",
        "title": "Study of halo for the ground state and proton widths for the first two excited states of 27P",
        "abstract": "The neutron asymptotic normalization coefficients (ANCs) for the virtual decay 27Mg \u2192 26Mg+n are determined from the angular distributions of the 26Mg(d, p)27Mg reaction leading to the ground, first and second excited states of 27Mg respectively, based on distorted wave Born approximation analysis (DWBA). According to charge symmetry of mirror nuclei, we extract the proton ANC and spectroscopic factor for 27P ground state and the proton widths of the first and second excited states of 27P. The rms radius of valence proton is then derived. Our result indicates that the 27P ground state has a proton halo structure.",
        "keywords": [
            "Asymptotic normalization coefficient",
            "Proton width",
            "Rms radius",
            "Spectroscopic factor"
        ],
        "authors": [
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Kao Neng Wu Li Yu Ho Wu Li/High Energy Physics and Nuclear Physics",
        "year": 2006
    },
    "aSwAXVrd": {
        "id": "aSwAXVrd",
        "title": "Indirect Measurement of Astrophysical 13C(a, n)16O S-Factors",
        "abstract": "",
        "keywords": [
            "asymptotic giant branch"
        ],
        "authors": [
            {
                "name": "bing guo",
                "org": ""
            },
            {
                "name": "zhihong li",
                "org": ""
            },
            {
                "name": "yunju li",
                "org": ""
            },
            {
                "name": "jun su",
                "org": ""
            },
            {
                "name": "xixiang bai",
                "org": ""
            },
            {
                "name": "yongshou chen",
                "org": ""
            },
            {
                "name": "q fan",
                "org": ""
            },
            {
                "name": "sunjun jin",
                "org": ""
            },
            {
                "name": "ertao li",
                "org": ""
            },
            {
                "name": "gang lian",
                "org": ""
            },
            {
                "name": "xin liu",
                "org": ""
            },
            {
                "name": "jiancheng liu",
                "org": ""
            },
            {
                "name": "nengchuan shu",
                "org": ""
            },
            {
                "name": "baoxiang wang",
                "org": ""
            },
            {
                "name": "youbao wang",
                "org": ""
            },
            {
                "name": "shengquan yan",
                "org": ""
            },
            {
                "name": "sheng zeng",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "danyang pang",
                "org": "peking university"
            },
            {
                "name": "maria lugaro",
                "org": "monash university clayton campus"
            },
            {
                "name": "j buntain",
                "org": "monash university clayton campus"
            }
        ],
        "venue": "Plasma Science & Technology",
        "year": 2012
    },
    "EuZkIYoR": {
        "id": "EuZkIYoR",
        "title": "Measurement of \u03b3 detector backgrounds in the energy range of 3\u20138 MeV at Jinping underground laboratory for nuclear astrophysics",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "YangPing Shen",
                "org": "China Institute of Atomic Energy"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy"
            },
            {
                "name": "WeiPing Liu",
                "org": "China Institute of Atomic Energy"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy"
            },
            {
                "name": "Lin Gan",
                "org": "China Institute of Atomic Energy"
            },
            {
                "name": "LvHua Qiao",
                "org": "China Institute of Atomic Energy"
            },
            {
                "name": "ShengQuan Yan",
                "org": "China Institute of Atomic Energy"
            },
            {
                "name": "Yong Zhou",
                "org": "China Institute of Atomic Energy"
            },
            {
                "name": "Qian Yue",
                "org": "Tsinghua University"
            },
            {
                "name": "Zhi Zeng",
                "org": "Tsinghua University"
            },
            {
                "name": "QingDong Hu",
                "org": "Tsinghua University"
            },
            {
                "name": "YuHao Mi",
                "org": "Tsinghua University"
            },
            {
                "name": "Wei Zhao",
                "org": "Tsinghua University"
            }
        ],
        "venue": "Science China-physics Mechanics & Astronomy",
        "year": 2017
    },
    "3R7xanai": {
        "id": "3R7xanai",
        "title": "Determination of astrophysical$^{7}$Be(p, \u03b3)$^{8}$B reaction rates from the$^{7}$Li(d, p)$^{8}$Li reaction",
        "abstract": "The 7Be(p, \u03b3)8B reaction plays a central role not only in the evaluation of solar neutrino fluxes but also in the evolution of the first stars. Study of this reaction requires the asymptotic normalization coefficient (ANC) for the virtual decay 8B g.s. \u2192 7Be + p. By using the charge symmetry relation, we obtain this proton ANC with the single neutron ANC of 8Li g.s. \u21927Li + n, which is determined with the distorted wave Born approximation (DWBA) and adiabatic distorted wave approximation (ADWA) analysis of the 7Li(d, p)8Li angular distribution. The astrophysical S-factors and reaction rates of the direct capture process in the 7Be(p, \u03b3)8B reaction are further deduced at energies of astrophysical relevance. The astrophysical S-factor at zero energy for direct capture, S 17(0), is derived to be (19.9 \u00b1 3.5) eV b in good agreement with the most recent recommended value. The contributions of the 1+ and 3+ resonances to the S-factor and reaction rate are also evaluated. The present result demonstrates that the direct capture dominates the 7Be(p, \u03b3)8B reaction in the whole temperature range. This work provides an independent examination to the current results of the 7Be(p, \u03b3)8B reaction.",
        "keywords": [
            "mirror system"
        ],
        "authors": [
            {
                "name": "xianchao du",
                "org": ""
            },
            {
                "name": "ertao li",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "bing guo",
                "org": ""
            },
            {
                "name": "zhihong li",
                "org": ""
            },
            {
                "name": "danyang pang",
                "org": ""
            }
        ],
        "venue": "Science China-physics Mechanics & Astronomy",
        "year": 2015
    },
    "da3OacbU": {
        "id": "da3OacbU",
        "title": "Production of 15O secondary beam for measurements of reactions of nuclear astrophysical interests",
        "abstract": "A 15O secondary beam was produced via 2H(14N, 15O*)n reaction in inverse kinematics on the secondary beam facility at the HI-13 tandem accelerator. The energy of the 15O secondary beam is (74.3 + 0.7) MeV, with a purity of 50% and the intensity of about 80 pnA-1\u00b7s-1 after collimation. We plan to use the 15O beam to measure key reactions involved in the nucleosynthesis process at several high-temperature astrophysical sites.",
        "keywords": [
            "Hot CNO cycle",
            "Nuclear astrophysics",
            "Reaction in inverse kinematics",
            "Secondary beam"
        ],
        "authors": [
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yun Lu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Yuanzineng Kexue Jishu/Atomic Energy Science and Technology",
        "year": 2005
    },
    "g0afGgQD": {
        "id": "g0afGgQD",
        "title": "Production of 13N secondary beam",
        "abstract": "A 13N secondary beam to be used in the study of nuclear astrophysics was produced by the 2H(12C, 13N)n reaction using the secondary beam line of the HI-13 tandem accelerator in Beijing. The energy of the 13N secondary beam is (70.2 \u00b1 0.7) MeV, with a purity of 91% and the intensity of about 10 s-1\u00b7pnA-1 after collimation. The beam can be used for the study of transfer reaction in inverse kinematics.",
        "keywords": [
            "Magnetic rigidity",
            "Nuclear reactions in inverse kinematics",
            "Secondary beam",
            "Speed filter"
        ],
        "authors": [
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Yuanzineng Kexue Jishu/Atomic Energy Science and Technology",
        "year": 2007
    },
    "cekQnq2l": {
        "id": "cekQnq2l",
        "title": "Thermonuclear 19F(p, ${{\\boldsymbol{\\alpha }}}_{0}$)16O reaction rate",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "J.J. He",
                "org": ""
            },
            {
                "name": "I. Lombardo",
                "org": ""
            },
            {
                "name": "Daniele Dell\u2019Aquila",
                "org": ""
            },
            {
                "name": "Yi Xu",
                "org": ""
            },
            {
                "name": "LiYong Zhang",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            }
        ],
        "venue": "Chinese Physics C",
        "year": 2018
    },
    "ekP9JstH": {
        "id": "ekP9JstH",
        "title": "Search for the halo effect in the 1H(6He, 6Li)n reaction",
        "abstract": "The angular distributions of the charge exchange reaction 1H(6He, 6Li)n were measured in reverse kinematics with a secondary 6He beam at the energy of 4.17 A MeV. The data were analysed in the context of a microscopic calculation. It is shown that both the ground state of 6He and the second excited state of 6Li (3.563 MeV, 0+) have a halo structure.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhichang Li.",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Qingbiao Shen",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Chengjian Lin",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "ChangBo Fu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2002
    },
    "Jw3nn0Ad": {
        "id": "Jw3nn0Ad",
        "title": "Neutron Spectroscopic Factors of 7 Li and Astrophysical 6 Li(n,\u03b3) 7 Li Reaction Rates",
        "abstract": "",
        "keywords": [
            "reaction rate"
        ],
        "authors": [
            {
                "name": "jun su",
                "org": ""
            },
            {
                "name": "bing guo",
                "org": ""
            },
            {
                "name": "xixiang bai",
                "org": ""
            },
            {
                "name": "zhichang li",
                "org": ""
            },
            {
                "name": "jiancheng liu",
                "org": ""
            },
            {
                "name": "youbao wang",
                "org": ""
            },
            {
                "name": "gang lian",
                "org": ""
            },
            {
                "name": "sheng zeng",
                "org": ""
            },
            {
                "name": "baoxiang wang",
                "org": ""
            },
            {
                "name": "shengquan yan",
                "org": ""
            },
            {
                "name": "yunju li",
                "org": ""
            },
            {
                "name": "ertao li",
                "org": ""
            },
            {
                "name": "q fan",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2010
    },
    "Hcj3tRXA": {
        "id": "Hcj3tRXA",
        "title": "Indirect measurement of nuclear reactions of astrophysical interest",
        "abstract": "Systematic indirect measurements of nuclear astrophysical reactions using the unstable ion beam facility GIRAFFE in CIAE were performed. We have measured the angular distributions of transfer reactions, such as 8Li(d,p) 9Li, 8Li(d,n)9Be and 8Li(p,d) 7Li in inverse kinematics, and derived the astrophysical S-factors or reaction rates for 8Li(n,\u03b3)9Li and 8Li(p,\u03b3)9Be by using asymptotic normalization coefficient (ANC) or spectroscopic factor methods. \u00a9 2010 American Institute of Physics.",
        "keywords": [
            "astrophysical s-factor",
            "asymptotic normalization",
            "indirect measurement",
            "reaction rate",
            "spectroscopic factor",
            "nuclear reactions",
            "nuclear astrophysics",
            "inverse kinematics",
            "asymptotic stability",
            "ion beam"
        ],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "YunJu Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Ertao Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "SunJun Jin",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "AIP Conference Proceedings",
        "year": 2010
    },
    "vevccexH": {
        "id": "vevccexH",
        "title": "Simulation and analysis of 13N+p elastic resonance scattering",
        "abstract": "The 13N+p elastic resonance scattering has been studied at the secondary radioactive beam facility of CIAE in inverse kinematics via a thick-target method. The excitation function for the 13N(p,p) scattering was obtained in the energy interval of Ecm\u22480.5-3.2 MeV with a 13N secondary beam of (47.8\u00b11.5) MeV. Careful analysis of the secondary beam components and extensive Monte-Carlo simulations enable the resolution of the experimental proton spectra. The resonance parameters for five low-lying levels in 14O were deduced by R-matrix fitting calculations with MULTI7 and SAMMY-M6-BETA. The present results show general agreement with those from a recent similar work, and thus confirm the observation of a new 0- level at 5.7 MeV in 14O with an improved width of 400(45) keV. \u00a9 2009 Chinese Physical Society and the Institute of High Energy Physics of the Chinese Academy of Sciences and the Institute of Modern Physics of the Chinese Academy of Sciences and IOP Publishing Ltd.",
        "keywords": [
            "elastic resonance scattering",
            "excitation function",
            "radioactive secondary beam",
            "thick-target method"
        ],
        "authors": [
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xing Qin",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "YunJu Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Chao Jiang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Chinese Physics C",
        "year": 2009
    },
    "0aHtc0se": {
        "id": "0aHtc0se",
        "title": "Enhancement of \u03b2+-decay rate of 22Na in metal Pd at low temperature",
        "abstract": "Temperature dependence of nuclear decays in metallic environments is a controversial issue. We measured the temperature dependence of the \u03b2+-decay half-life of22Na implanted into the metal host of palladium. It is found that the \u03b2+ -decay half-life of22Na in the metal Pd cooled to T = 15 K is shorter by 0.46(14)% than that at room temperature. The result is consistent in sign with, but clearly smaller than, the estimated one by the Debye model. \u00a9 2008 Chinese Physical Society and IOP Publishing Ltd.",
        "keywords": [],
        "authors": [
            {
                "name": "Gang Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Baoxiang Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Chao Jiang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Sheng Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "YongNan Zheng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Shengyun Zhu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Lihua Zhu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Youbao Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Bing Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "YunJu Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xing Qin",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2008
    },
    "Yb1CzGHT": {
        "id": "Yb1CzGHT",
        "title": "High resolution ionization chamber detector",
        "abstract": "An IC+PSSD (position sensitive silicon detector) telescope for the identification of heavy ion reaction products at low energy was developed. The telescope consists of an ionization chamber for the measurement of specific energy loss \ufffd\ufffdE and a two-dimensional PSSD with the effective area of 45\ufffd\ufffd45 mm2 and thickness of 45 \ufffd\ufffdm for the measurement of the residual energy E. The performance of the IC detector was tested with alpha particle from the 241Am source. The operating conditions of the shaping time of 2.0\ufffd\ufffds, EGC=0.2 V/cm-torr and EAG/EGC=4.0 were recommended for the IC detector with P10 gas. The measured energy resolution is limited by the energy loss straggling in the gas and is close to optimum values of this kind of detectors.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Jun Lu",
                "org": "Institute of Modern Physics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Modern Physics,Inst of Modern Physics),Lanzhou,China"
            },
            {
                "name": "Songling Li",
                "org": "Institute of Modern Physics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Modern Physics,Inst of Modern Physics),Lanzhou,China"
            },
            {
                "name": "Hushan Xu",
                "org": "Institute of Modern Physics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Modern Physics,Inst of Modern Physics),Lanzhou,China"
            },
            {
                "name": "Yongtai Zhu",
                "org": "Institute of Modern Physics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Modern Physics,Inst of Modern Physics),Lanzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Institute of Modern Physics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Modern Physics,Inst of Modern Physics),Lanzhou,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "Institute of Modern Physics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Modern Physics,Inst of Modern Physics),Lanzhou,China"
            }
        ],
        "venue": "Chinese journal of nuclear physics",
        "year": 1995
    },
    "eLWTlumC": {
        "id": "eLWTlumC",
        "title": "Spectroscopic factors for low-lying N 16 levels and the astrophysical N 15 (n, \ufffd\ufffd) N 16 reaction rate",
        "abstract": "Background: Fluorine is a key element for nucleosynthetic studies since it is extremely sensitive to the physical conditions within stars. The astrophysical site to produce fluorine is suggested to be asymptotic giant branch stars. In these stars the N15(n,\ufffd\ufffd)N16 reaction could affect the abundance of fluorine by competing with N15(\ufffd\ufffd,\ufffd\ufffd)F19. Purpose: The N15(n,\ufffd\ufffd)N16 reaction rate depends directly on the neutron spectroscopic factors of the low-lying states in N16. Shell model calculations and two previous measurements of the (d,p) reaction yielded the spectroscopic factors with a discrepancy by a factor of \ufffd\ufffd2. The present work aims to explore these neutron spectroscopic factors through an independent transfer reaction and to determine the stellar rate of the N15(n,\ufffd\ufffd)N16 reaction. Methods: The angular distributions of the N15(Li7,Li6)N16 reaction populating the ground state and the first three excited states in N16 are measured using a Q3D magnetic spectrograph and are used to derive the spectroscopic factors of these states based on distorted wave Born approximation analysis. Results: The spectroscopic factors of these four states are extracted to be 0.96 \ufffd\ufffd 0.09, 0.69 \ufffd\ufffd 0.09, 0.84 \ufffd\ufffd 0.08, and 0.65 \ufffd\ufffd 0.08, respectively. Based on the new spectroscopic factors we derive the N15(n,\ufffd\ufffd)N16 reaction rate. Conclusions: The accuracy and precision of the spectroscopic factors are enhanced due to the first application of high-precision magnetic spectrograph for resolving the closely spaced N16 levels which cannot be achieved in most recent measurements. The present result demonstrates that two levels corresponding to neutron transfers to the 2s1/2 orbit in N16 are not good single-particle levels although N15 is a closed neutron-shell nucleus. This finding is contrary to the shell model expectation. The present work also provides an independent examination to shed some light on the existing discrepancies in the spectroscopic factors and the N15(n,\ufffd\ufffd)N16 rate. ? 2014 American Physical Society.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "B. Guo",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhihong Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Yunju Li",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jun Su",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Danyang Pang",
                "org": "Beijing University of Aeronautics and Astronautics(Beijing University of Aeronautics and Astronautics,Beijing Univ. of Aero. and Astron.),Beijing,China"
            },
            {
                "name": "Shengquan Yan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Zhendong Wu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Ertao Li",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Xixiang Bai",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Xianchao Du",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Qi Fan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Lin Gan",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "J. J. He",
                "org": "Institute of Modern Physics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Modern Physics,Inst of Modern Physics),Lanzhou,China"
            },
            {
                "name": "Sunjun Jin",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "L. Jing",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "L. Li",
                "org": "Institute of Modern Physics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Modern Physics,Inst of Modern Physics),Lanzhou,China"
            },
            {
                "name": "Zhichang Li.",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "G. Lian",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Jiancheng Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Y. P. Shen",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Y. B. Wang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "X. Q. Yu",
                "org": "Institute of Modern Physics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Modern Physics,Inst of Modern Physics),Lanzhou,China"
            },
            {
                "name": "S. Zeng",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Liyong Zhang",
                "org": "Institute of Modern Physics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Modern Physics,Inst of Modern Physics),Lanzhou,China"
            },
            {
                "name": "W. J. Zhang",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Physical Review C - Nuclear Physics",
        "year": 2014
    },
    "pvaDlVGp": {
        "id": "pvaDlVGp",
        "title": "Experimental studies on the primordial lithium abundance",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zhihong li",
                "org": ""
            },
            {
                "name": "ertao li",
                "org": ""
            },
            {
                "name": "jun su",
                "org": ""
            },
            {
                "name": "bing guo",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "yunju li",
                "org": ""
            },
            {
                "name": "yongshou chen",
                "org": ""
            },
            {
                "name": "suqing hou",
                "org": ""
            },
            {
                "name": "xixiang bai",
                "org": ""
            },
            {
                "name": "shengquan yan",
                "org": ""
            },
            {
                "name": "youbao wang",
                "org": ""
            },
            {
                "name": "baoxiang wang",
                "org": ""
            },
            {
                "name": "sheng zeng",
                "org": ""
            },
            {
                "name": "gang lian",
                "org": ""
            },
            {
                "name": "sunjun jin",
                "org": ""
            },
            {
                "name": "xin liu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "l4IULhDY": {
        "id": "l4IULhDY",
        "title": "Astrophysical Rates for the 6He(p, gamma)7Li Reaction",
        "abstract": "",
        "keywords": [
            "excited states",
            "inverse kinematics"
        ],
        "authors": [
            {
                "name": "ertao li",
                "org": ""
            },
            {
                "name": "zhihong li",
                "org": ""
            },
            {
                "name": "jun su",
                "org": ""
            },
            {
                "name": "bing guo",
                "org": ""
            },
            {
                "name": "yunju li",
                "org": ""
            },
            {
                "name": "shengquan yan",
                "org": ""
            },
            {
                "name": "xixiang bai",
                "org": ""
            },
            {
                "name": "youbao wang",
                "org": ""
            },
            {
                "name": "baoxiang wang",
                "org": ""
            },
            {
                "name": "gang lian",
                "org": ""
            },
            {
                "name": "sheng zeng",
                "org": ""
            },
            {
                "name": "xiao fang",
                "org": ""
            },
            {
                "name": "weijuan zhao",
                "org": "zhengzhou university"
            },
            {
                "name": "weiping liu",
                "org": ""
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2011
    },
    "qdSPFYtQ": {
        "id": "qdSPFYtQ",
        "title": "Calculation of heavy ion beam energy for tandem upgrading project",
        "abstract": "The heavy ion beam energy, as well as the charge stripping efficiency, was calculated by using the charge state stripping formula and empirical formula of stable isotope mass number. The result is helpful for compromising between beam energy and beam intensity when designing a tandem experiment.",
        "keywords": [
            "Beam energy",
            "Charge stripping",
            "Charge stripping efficiency",
            "Heavy ion"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "China Institute of Atomic Energy(China Institute of Atomic Energy,China Inst of Atomic Energy),Beijing,China"
            }
        ],
        "venue": "Yuanzineng Kexue Jishu/Atomic Energy Science and Technology",
        "year": 2007
    },
    "F1Uuoqd3": {
        "id": "F1Uuoqd3",
        "title": "Analysis of major constituents in Fructus aurantii-Magnolia bark decoction by UPLC-PDA.",
        "abstract": "A ultraperformance liquid chromatography (UPLC)-photodiode array (PDA) detection method was established for the simultaneous determination of seven constituents in Fructus aurantii-Magnolia bark decoction: naringin, hesperidin, neohesperidin, narirutin, meranzin hydrate, honokiol and magnolol. These were separated in <17 min using a C18 column with gradient elution using (a) acetonitrile, (b) water and (c) acetic acid at a flow rate of 0.3 mL/min, and with a PDA detector. All calibration curves showed good linear regression (r(2) > 0.9992) within the test ranges. The method was validated for speci\ufb01city, accuracy, precision and limits of detection. The proposed method was found to be suitable for the quality assessment of the formula.",
        "keywords": [],
        "authors": [
            {
                "name": "Zhi-hua Xing",
                "org": "Laboratory of Ethnopharmacology, Institute of Integrated Traditional Medicine and Western Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha 410008, Hunan Province, China National Key Clinical Specialist Vocational School of TCM Encephalopathy, Xiangya Hospital, Central South University, Changsha, China."
            },
            {
                "name": "Wei-jun Peng",
                "org": "Laboratory of Ethnopharmacology, Institute of Integrated Traditional Medicine and Western Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha 410008, Hunan Province, China National Key Clinical Specialist Vocational School of TCM Encephalopathy, Xiangya Hospital, Central South University, Changsha, China."
            },
            {
                "name": "Wei Huang",
                "org": "Laboratory of Ethnopharmacology, Institute of Integrated Traditional Medicine and Western Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha 410008, Hunan Province, China National Key Clinical Specialist Vocational School of TCM Encephalopathy, Xiangya Hospital, Central South University, Changsha, China TCM Pharmacogenetics Laboratory, Central South University, Changsha, China huangweidavid@aliyun.com."
            },
            {
                "name": "Xi Huang",
                "org": "Laboratory of Ethnopharmacology, Institute of Integrated Traditional Medicine and Western Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha 410008, Hunan Province, China National Key Clinical Specialist Vocational School of TCM Encephalopathy, Xiangya Hospital, Central South University, Changsha, China TCM Pharmacogenetics Laboratory, Central South University, Changsha, China."
            },
            {
                "name": "Wei-ping Liu",
                "org": "Laboratory of Ethnopharmacology, Institute of Integrated Traditional Medicine and Western Medicine, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha 410008, Hunan Province, China National Key Clinical Specialist Vocational School of TCM Encephalopathy, Xiangya Hospital, Central South University, Changsha, China."
            }
        ],
        "venue": "Journal of chromatographic science",
        "year": 2014
    },
    "6TpMZCYD": {
        "id": "6TpMZCYD",
        "title": "Effect of Baoxin Decoction on Plasma Vascular Endothelial Growth Factor and Heart Rate Variability in Patients with Stable Angina Pectoris",
        "abstract": "Objective:To investigate the effect of Baoxin decoction on plasma vascular endothelial growth factor(VEGF) and Heart rate variability(HRV) in patients with stable angina pectoris.Methods:Eighty-two patients were randomly divided into two groups:therapy group and control group.The patients in therapy group were treated with Baoxin decoction and routine treatments,and those in control group were subjected to routine treatments.The levels of plasma VEGF and HRV before and 4 weeks after therapy were measured in these two groups.The curative effectiveness was evaluated.Results:There was no significant difference in plasma VEGF and HRV between two groups before treatment(P> 0.05).After treatment,the 1evels of VEGF was obviously elevated in therapy group(P< 0.05),but no significant changes were found in control group(P>0.05).the 1evels of HRV were obviously elevated in therapy group and control group.(P< 0.05 or P<0.001),Compared with control group,the changes of HRV in therapy group were significant(P<0.05).Conclusion:Baoxin decoction can elevate the levels of plasma VEGF and improve HRV.It might work through elevating the plasma VEGF and improving HRV of patients,which facilitates building the subordinate circulatory system of coronary,and helps to improve prognosis.",
        "keywords": [
            "Heart Rate",
            "Baoxin Decoction",
            "Angina Pectoris",
            "Vascular Endothelial Growth Factor"
        ],
        "authors": [
            {
                "name": "LIN Zhan-zeng",
                "org": "The Fourth Central Hospital,Tianjin,,China"
            },
            {
                "name": "XING Zhi-hua",
                "org": "Institute of Integrative Medicine,Xiangya Hospital,Central South University,Changsha,,Hunan,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Institute of Integrative Medicine,Xiangya Hospital,Central South University,Changsha,,Hunan,China"
            }
        ],
        "venue": "Journal of Hebei North University(Medical Edition)",
        "year": 2009
    },
    "uc3NYREk": {
        "id": "uc3NYREk",
        "title": "Clinical Study of Relationships Between FIB HS-CRP Respectively in CHD with Various TCM Syndromes",
        "abstract": "Objective: The study is to provide an objective proof for syndrome differentiation of traditional Chinese medecine(TCM) and guide clinical treatment and syndromes in coronary heart disease(CHD).Methods: The patients with CHD were divided into 6 groups,such as heart blood stasis,retention of phlegm in heart vessel,stagnation of qi due to cold,heart-kidney yin deficiency,dual deficiency of qi and yin,dual deficiancy yang and qi.30members of the control group were randomly selected from the medical center.The levels of fibrinogen(fib)and high-sensititive reactive protein(HS-CRP) has been detectded.Results: The levels of fibrinogen(fib) of dual deficiancy yang and qi group were statistically higher than those of control group.heart-kidney yin deficiency,heart blood stasis group,dual deficiency of qi and yin(P<0.05).FIB levels of stagnation of qi due to cold group were statistically higher than control and heart-kidney yin deficiency group(P<0.05).Hs-crp levels of heart blood stasis group were statistically higher than the other 6 groups(P<0.05).Conclusion: from this experiment we can come to the conclusion that :FIB,HS-CRP could be severed as an objective proof in syndrome differentiation of TCM with CHD,especially HS-CRP in the heart blood stasis group and FIB in dual deficiancy yang and qi group.",
        "keywords": [
            "TCM syndromes",
            "coronary heart disease",
            "HS-CRP",
            "FIB"
        ],
        "authors": [
            {
                "name": "XING Zhi-hua",
                "org": "Institute of Combined Traditional Chinese and Westem Medicine,Xiangya Hospital,Central South University, Department of Integrated Chinese and Western Medicine,and Key Lab of Gan State Administration of Traditional Chinese Medicine of China,Xiangya Hospital,Central South University,Changsha ,Hunan,China"
            },
            {
                "name": "XU Cai-yun",
                "org": "Institute of Combined Traditional Chinese and Westem Medicine,Xiangya Hospital,Central South University, Department of Integrated Chinese and Western Medicine,and Key Lab of Gan State Administration of Traditional Chinese Medicine of China,Xiangya Hospital,Central South University,Changsha ,Hunan,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Institute of Combined Traditional Chinese and Westem Medicine,Xiangya Hospital,Central South University, Department of Integrated Chinese and Western Medicine,and Key Lab of Gan State Administration of Traditional Chinese Medicine of China,Xiangya Hospital,Central South University,Changsha ,Hunan,China"
            },
            {
                "name": "YANG Tian-lun",
                "org": "Department of Cardiology,Xiangya Hospital,Central South University,Changsha ,Hunan,China"
            },
            {
                "name": "XIAO Yan-ping",
                "org": "Institute of Combined Traditional Chinese and Westem Medicine,Xiangya Hospital,Central South University, Department of Integrated Chinese and Western Medicine,and Key Lab of Gan State Administration of Traditional Chinese Medicine of China,Xiangya Hospital,Central South University,Changsha ,Hunan,China"
            },
            {
                "name": "CUI Han-jin",
                "org": ""
            }
        ],
        "venue": "Chinese Archives of Traditional Chinese Medicine",
        "year": 2011
    },
    "pmVg4Ifj": {
        "id": "pmVg4Ifj",
        "title": "Influence of Baoxin Decoction on serum VEGF in patients with myocardial infarction after PTCA",
        "abstract": "Objective To study the influence of Chinese herbal drugs on serum vascular endothelial growth factor(VEGF) and heart function in patients with myocardial infarction(MI).Methods To divide randomly 54 cases into 3 groups,including the control group with 8 cases(group1),percutaneous transluminal angioplasty(PTCA) group with 22 cases(group2) and Baoxin Decoction group with 24 cases(group3).The concentration of serum VEGF was detected by enzyme-linked immunosorbent(assay)(ELISA) on 0~(th),1~(st),7~(th),14~(th) and 21~(st) day respectively after the treatment.The colour Doppler(ultrasonic) cardiograph was used for detect the left ventricular ejection fraction(LVEF) on 1~(st) and 21~(st) day after the treatment. Result The concentration of serum VEGF increased gradually after the beginning of the treatment,reached the peak on 1~(st) day and then decreased gradually.The concentration of serum VEGF was not significant different between group2 and group3 on 0~(th),1~(st),7~(th) and 14~(th) day,but higher than that of group1(P<0.01).On 21~(st) day the concentration of serum VEGF in group3 was higher than that in group2(P<0.01) and obviously higher than that in group1,but there was no significant difference between group2 and group1.On 1~(st) day LVEF was not significant different between group2 and group3 and lower than that in group1(P<0.01).On 21~(st) day LVEF was higher in group3 than that in group2(P<0.05).Conclusion Baoxin Decoction can promote the collateralization in ischemic zone,protect cardiac muscle and improve the recovery of heart function through regulating the VEGF expression and keep VEGF a suitable serum concentration.",
        "keywords": [
            "myocardial infarction",
            "vascular endothelial growth factor",
            "Baoxin Decoction"
        ],
        "authors": [
            {
                "name": "ZHANG Zong-qi",
                "org": "Institute of Integration of Chinese and Western Medicine,Xiangya Hospital,Zhongnan University,Hunan "
            },
            {
                "name": "XING Zhi-hua",
                "org": "Institute of Integration of Chinese and Western Medicine,Xiangya Hospital,Zhongnan University,Hunan "
            },
            {
                "name": "TANG Tao",
                "org": "Institute of Integration of Chinese and Western Medicine,Xiangya Hospital,Zhongnan University,Hunan "
            },
            {
                "name": "LIU Wei-ping",
                "org": "Institute of Integration of Chinese and Western Medicine,Xiangya Hospital,Zhongnan University,Hunan "
            },
            {
                "name": "YI Liang",
                "org": "Institute of Integration of Chinese and Western Medicine,Xiangya Hospital,Zhongnan University,Hunan "
            }
        ],
        "venue": "Journal of Beijing University of Traditional Chinese Medicine",
        "year": 2006
    },
    "a6t0rBbi": {
        "id": "a6t0rBbi",
        "title": "Clinical Study of Relationships between Fibrinogen Respectively in CHD with Various TCM Syndromes",
        "abstract": "Objective:To provide an objective proof for syndrome differentiati on of traditional Chinese medecine(TCM).Methods:The patients with CHD were divided into 6 groups,according to heart blood stasis,retention of phlegm in hea rt vessel,stagnation of qi due to cold,heart-kidney yin deficiency,dual def iciency of qi and yin,dual deficiancy yang and qi.30 members of the control gr oup were randomly selected from the medical center.The level of fib has been de tected.Results:Fib levels of dual deficiancy yang and qi group were statistically higher than those of control group.Heart-kidney yin deficiency,heart blood s tasis group and dual deficiency of qi and yin.When 7 groups compared to each other,in these 21 pairs,6 pairs had statistical differences,but 15 pairs do not have them.The positive rate of acute coronary syndrome(ACS) in these 6 groups of CHD had statistical differences.Conclusion:Fib level could not be efficient eno ugh to serve as an objective proof for differentiation TCM syndromes of CHD,how ever,it gives a further demonstration that it is an indicator of the severity of CHD.",
        "keywords": [
            "TCM syndromes",
            "Fibrinogen",
            "Coronary heart disease"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "Institute of Combined Traditional Chinese and Westem Medicine,Xiangya Hospit al,Central South University,%%#Changsha %%# 2Xiangya Hospital,Central South University%%#Changsha %%#"
            },
            {
                "name": "XIAO Yan-ping",
                "org": "Institute of Combined Traditional Chinese and Westem Medicine,Xiangya Hospit al,Central South University,%%#Changsha %%# 2Xiangya Hospital,Central South University%%#Changsha %%#"
            },
            {
                "name": "XING Zhi-hua",
                "org": "Institute of Combined Traditional Chinese and Westem Medicine,Xiangya Hospit al,Central South University,%%#Changsha %%# 2Xiangya Hospital,Central South University%%#Changsha %%#"
            }
        ],
        "venue": "Journal of Emergency in Traditional Chinese Medicine",
        "year": 2010
    },
    "4gqcDaop": {
        "id": "4gqcDaop",
        "title": "Effect of Baoxin Decoction on Plasma Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor in Patients with Stable Angina Pectoris",
        "abstract": "Objective: To investigate the effect of Baoxin decoction on plasma vascular endothelial growth factor(VEGF) and basic fibroblast growth factor(bFGF) in patients with stable angina pectoris.Methods: Eighty-two patients were randomly divided into two groups: therapy group and control group.The patients in therapy group were treated with Baoxin decoction,and those in control group were subjected to routine treatments.The levels of plasma VEGF and bFGF before and 4 weeks after therapy were measured in these two groups.The curative effectiveness was evaluated.Results: There was no significant difference in plasma VEGF and bFGF between two groups before treatment(P>0.05).After treatment,the levels of VEGF and bFGF were obviously elevated in therapy group(P<0.05),but no significant changes were found in control group (P>0.05).Conclusion: Baoxin decoction can elevate the levels of plasma VEGF and bFGF.It might work through elevating the plasma VEGF and bFGF levels of patients,which facilitates building the subordinate circulatory system of coronary,and helps to cure coronary heart disease.",
        "keywords": [
            "Vascular endothelial growth factor",
            "Baoxin decoction",
            "Basic fibroblast growth factor",
            "Stable angina pectoris"
        ],
        "authors": [
            {
                "name": "Yi Liang",
                "org": ",et al.Institute of Integrated Traditional Chinese and Western Medicine,Xiangya Hospital,Central South University,Changsha ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": ",et al.Institute of Integrated Traditional Chinese and Western Medicine,Xiangya Hospital,Central South University,Changsha ,China"
            }
        ],
        "venue": "Chinese Journal of Rehabilitation",
        "year": 2006
    },
    "9QKucTyR": {
        "id": "9QKucTyR",
        "title": "Effect of Tianmagouteng Decoction on Antioxygen and Carotid Artery Atherosclerosis in Patients with Hypertension",
        "abstract": "Objective:To observe the effect of Tianmagouteng decoction on antioxygen and carotid artery atherosclerosis in hypertensive patients with hyperactivity of liver.Methods:Sixty hypertensive patients with hyperactivity of liver were randomly divided into tianmagouteng decoction group receiving tianmagouteng decoction treatment and felodipine group subject to felodipine.Before and 6 month after treatment,serum catalase(CAT)malonaldehyde(MDA)activity and carotid artery intima-media thickness(IMT)were measured.Results:After 6 months of treatment,the blood pressure was declined in two groups and there was no significant difference between two groups(P>0.05).The serum CAT was significantly increased in tianmagouteng decoction group compared with that of felodipine group(P<0.01);The serum MDA was significantly decreased in tianmagouteng decoction group compared with that of felodipine group(P<0.01).and the IMT significantly decreased in tianmagouteng decoction group compared with that of felodipine group(P<0.05).Conclusion:Tianmagouteng decoction can reduce IMT in the hypertensive patients with hyperactivity of liver,and increase antioxygen activity.",
        "keywords": [
            "Antioxidants",
            "Tianmagouteng Decoction",
            "Carotid Artery Diseases",
            "Hypertension"
        ],
        "authors": [
            {
                "name": "LIN Zhan-zeng",
                "org": ",et al 1.Tianjin Fourth Central Hospital,Tianjin,,China"
            },
            {
                "name": "XING Zhi-hua",
                "org": "Xiangya Hospital,Zhongnan University,Changsha,,Hunan,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Xiangya Hospital,Zhongnan University,Changsha,,Hunan,China"
            }
        ],
        "venue": "Journal of Hebei North University(Medical Edition)",
        "year": 2009
    },
    "yUCbzQEm": {
        "id": "yUCbzQEm",
        "title": "Effect of Yiqi Huoxue therapy on serum IL-6,ICAM-1 and TNF-\u03b1 in patients with stable angina pectoris in qi deficiency and blood stasis",
        "abstract": "Objective To investigate the effects of Baoxin decoction on serum IL-6,ICAM-1 and TNF-\u03b1 in patients with stable angina pectoris.Methods 60 patients were randomly divided into treatment group treated with Baoxin decoction and control group treated with routine treatments.The curative effects in both groups and the levels of serum IL-6,ICAM-1 and TNF-\u03b1 were measured before treatment and after 4 weeks therapy.Results The curative effects in treatment group was much better than that in control group(P<0.05),the levels of serum IL-6,TNF-\u03b1 and ICAM-1 in treatment group after treatment were obviously decreased(P<0.01).Conclusion Baoxin decoction is exact effective to cure coronary heart disease with stable angina pectoris,and the mechanism may be through inhibiting the levels of serum IL-6,ICAM-1 and TNF-\u03b1 and decreasing the inflammation reaction.",
        "keywords": [
            "related inflammatory molecules",
            "stable angina pectoris",
            "Yiqi Huoxue therapy"
        ],
        "authors": [
            {
                "name": "PENG Wei-jun",
                "org": "Institute of Integrated Chinese and Western Medicine,Xiangya Hospital,Central South University,Changsha,Hunan,,China"
            },
            {
                "name": "XING Zhi-hua",
                "org": "Institute of Integrated Chinese and Western Medicine,Xiangya Hospital,Central South University,Changsha,Hunan,,China"
            },
            {
                "name": "LIAO Xiang",
                "org": "Institute of Integrated Chinese and Western Medicine,Xiangya Hospital,Central South University,Changsha,Hunan,,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Institute of Integrated Chinese and Western Medicine,Xiangya Hospital,Central South University,Changsha,Hunan,,China"
            }
        ],
        "venue": "Journal of Traditional Chinese Medicine University of Hunan",
        "year": 2011
    },
    "Wxn9yWmj": {
        "id": "Wxn9yWmj",
        "title": "Clinical Effectiveness of Baoxin Decoction on Coronary Heart Disease with Stable Angina Pectoris and Effect of that on plasma Basic Fibroblast Growth Factor",
        "abstract": "Objective To observe the curative effect of Baoxin decoction on patients with stable angina pectoris in coronary heart disease and effect of that on plasma basic fibroblast growth factor(bFGF).Methods 82 Cases were randomly divided into two groups: curative group and control group,which were treated respectively with Baoxin docoction and western medicine.The curative effect on the patients and the change of bFGF were compared after 4 weeks treatment.Results For all patients,angina pectoris and electrocardiogram have been much improved(P<0.05).There was no significant difference of curative effect between the two treatments(P>0.05).But the curative group improved clinical symptom better than the control group did(P<0.05).Moreover,it was observed that plasma bFGF in the curative group notably increased after treatment,and the difference between pretreatment and posttreatment is significant(P<(0.01)).Conclusion Baoxin decotion has curative effect on patients with stable angina pectoris in coronary heart disease.It might work by elevating the plasma bFGF level of patients,which facilitates building the subordinate circulatory system of coronary,and helps to cure coronary heart disease.",
        "keywords": [
            "coronary heart disease",
            "stable angina pectoris",
            "Baoxin decotion",
            "basic fibroblast growth factor(bFGF)"
        ],
        "authors": [
            {
                "name": "YI Liang",
                "org": "Institute of Integrated Traditional Chinese and Western Medicine,Xiangya Hospital,Central South University,Changsha ,China"
            },
            {
                "name": "Liu Weiping",
                "org": "Institute of Integrated Traditional Chinese and Western Medicine,Xiangya Hospital,Central South University,Changsha ,China"
            }
        ],
        "venue": "Journal of Hunan Traditional Chinese Medicine University of Hunan",
        "year": 2005
    },
    "cIEujrT7": {
        "id": "cIEujrT7",
        "title": "Relationships between Plasma Fibrinogen in Coronary Heart Disease with Various TCM Syndromes",
        "abstract": "Objective:To provide an objective proof for syndrome differentiation of traditional Chinese medicine(TCM)and guide clinical treatment and syndromes in coronary heart disease(CHD).Methods:The patients with CHD were divided into 6 groups:heart blood stasis,retention of phlegm in heart vessel,stagnation of qi due to cold,heart-kidney yin deficiency,dual deficiency of qi and yin,dual deficiency yang and qi.Thirty healthy volunteers randomly selected from the medical center served as control group.The level of serum fibrinogen was determined.Results:The serum fibrinogen level in dual deficiency yang and qi group was statistically higher than in control group,and the groups of heart-kidney yin deficiency,heart blood stasis,dual deficiency of qi and yin(P<0.05).The serum fibrinogen level in dual deficiency yang and qi was the highest,followed by stagnation of qi due to cold,retention of phlegm in heart vessel,dual deficiency of qi and yin,heart blood stasis,heart-kidney yin deficiency.The serum fibrinogen level in dual deficiency yang and qi was significantly higher than in control group,heart-kidney yin deficiency group,heart blood stasis group and dual deficiency of qi and ying group(P<0.05).Conclusion:The changes of serum fibrinogen level may be related to the severity of CHD.",
        "keywords": [
            "TCM syndromes",
            "coronary heart disease",
            "fibrinogen"
        ],
        "authors": [
            {
                "name": "XU Cai-yun",
                "org": ",et al.Institute of Integrated Traditional Chinese and Western Medicine,Department of Integrated Chinese and Western Medicine,and Key Lab of Gan State Administration of Traditional Chinese Medicine of China,Xiangya Hospital,Central South University,Changsha ,China"
            },
            {
                "name": "XING Zhi-hua",
                "org": ",et al.Institute of Integrated Traditional Chinese and Western Medicine,Department of Integrated Chinese and Western Medicine,and Key Lab of Gan State Administration of Traditional Chinese Medicine of China,Xiangya Hospital,Central South University,Changsha ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": ",et al.Institute of Integrated Traditional Chinese and Western Medicine,Department of Integrated Chinese and Western Medicine,and Key Lab of Gan State Administration of Traditional Chinese Medicine of China,Xiangya Hospital,Central South University,Changsha ,China"
            }
        ],
        "venue": "Chinese Journal of Rehabilitation",
        "year": 2010
    },
    "JsyN7tiX": {
        "id": "JsyN7tiX",
        "title": "The Innovation Mechanism and Laws of Inspiration and Intuition Thought",
        "abstract": "The inspiration and intuition activity takes on a unique thought innovation form,has the process stages and its own mechanisms,namely the thought movement choice mechanism,the thought movement induction mechanism,the thought intuition's high-level simplification mechanism,the thought lifting mechanism and the thought reconstruction mechanism.These thought mechanisms profoundly reflects the basic laws of inspiration and intuition innovations.",
        "keywords": [
            "law",
            "mechanism",
            "inspiration and intuition thought",
            "innovation"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "Party School of Shanghai Municipal Party Committee,Shanghai ,China"
            }
        ],
        "venue": "Academic Journal of Jinyang",
        "year": 2007
    },
    "ZMCk0F20": {
        "id": "ZMCk0F20",
        "title": "Construction of the Harmonious Society and System Thinking",
        "abstract": "In this paper,the author believes that the construction of the harmonious society has become the contemporary social consensus,analyses the construction of the socialist harmonious society with system thinking and points out that the open principle,the integrity principle,the complex principle and the practicality of dynamic control are necessary in the construction of the socialism harmonious society.",
        "keywords": [
            "System thinking",
            "Harmonious society",
            "Instruction"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "Shanghai Municipal Party School,Shanghai ,China"
            }
        ],
        "venue": "Chinese Journal of Systems Science",
        "year": 2010
    },
    "5X5bRoTM": {
        "id": "5X5bRoTM",
        "title": "Image Thinking Shape of Thinking Innovation",
        "abstract": "The Image thinking innovation is undoubtedly the important basic shape of innovative thinking.The image thinking innovation can be divided into two,brain physiological activity and the thinking information sport mechanism of people.The former exists in left and right brain functioning coherent complementary mechanism and the brain physiology is the second signal in people's reflecting systematic mechanism.The latter lies in the isomorphism mechanism of thinking with similar information and integration mechanism of the thinking information.The image thinking innovative campaign will inevitably lead to the following mechanism of its own internal rules: 1.Image infiltration with legal structure,that is,\"will\" and \"picture\" mutually penetrated and integrated into one,becomes innovative thinking of the image of the results.2.It is a total combination of image thinking,a total of materials as a mutual penetration and combination.3.The thinking of the legal time and space with various image materials forms combinations.4.The overall image of the same thinking that all elements connect with each other,mutual integration forms an overall image of thinking.",
        "keywords": [
            "law",
            "thinking innovation",
            "image thinking"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "Philosophy Section,Party School of Shanghai Party Committee,Shanghai ,China"
            }
        ],
        "venue": "Journal of Xuzhou Normal University(Philosophy and Social Sciences Edition)",
        "year": 2007
    },
    "kbFZ1Z2v": {
        "id": "kbFZ1Z2v",
        "title": "Marx's Theory on Man's Development and Its Value in Contemporary China",
        "abstract": "What Karl Marx brings forth is that the essence of man' s development lies in the objectification of his intrinsic force and the possession of his own essence in the course;man' s development, social progress as well as his objective world can promote each other; and man' s development is intrinsically regulated by his own social activity. Marx' s ideas are of guiding value to our practising the scientific concept of people-centred development, and the realization of man's overall development in the course of deepening reform and promoting socialist civilization.",
        "keywords": [
            "Karl Marx",
            "value",
            "contemporary China",
            "man's development"
        ],
        "authors": [
            {
                "name": "Liu Weiping",
                "org": "Department of Philosophy,Party School of the CPC Shanghai Municipal Committee, Shanghai ,China"
            }
        ],
        "venue": "Dongjiang Journal",
        "year": 2006
    },
    "DS6jP6Ei": {
        "id": "DS6jP6Ei",
        "title": "On Implication of Thinking Innovation and its Systematic Structure and Features",
        "abstract": "Thinking innovation refers to integrated thinking process of all activities with innovation and social value,characterized by active pursuit of difference,initiative,unexpectedness and comprehensive complement.As a sophisticated thinking activity of human beings,essentially it belongs to the process of systemization.Thinking innovation has multi-level structures including psychological structure,constituent element structure,thinking ability structure and main-part structure.",
        "keywords": [
            "structure",
            "system",
            "thinking innovation",
            "feature"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "Department of Philosophy,The Party School of Shanghai Municipal Committee of the CPC,Shanghai ,China"
            }
        ],
        "venue": "Journal of Anhui Institute of Education",
        "year": 2007
    },
    "Jn4FjWbR": {
        "id": "Jn4FjWbR",
        "title": "On the Self-organization of Thought Innovation",
        "abstract": "Looked from the significance of knowledge sociology,the thoughtinnovation-socialized process has three stages.In subconscious thought innovation stage,there are microscopic fluctuations reflecting social thought system interior to the conventional thought.In hasten thought innovation stage,thought innovation microscopic fluctuation was amplified as a result of thought equilibrium from the convention state.In revealing thought innovation stage,each kind of thought innovation cooperat harmoniously with the knowledge information and form a new level of thought.",
        "keywords": [
            "the thought innovation",
            "self-organization",
            "diffusion structure",
            "fluctuates"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "Department of Philosophy,Shanghai Municipal Committee Party School,China"
            }
        ],
        "venue": "Journal of Hunan University(Social Sciences)",
        "year": 2007
    },
    "qMwVY5td": {
        "id": "qMwVY5td",
        "title": "On the Characteristics and Cultural Basis of the Social Structure Transition in Contemporary China",
        "abstract": "The contemporary social structure levels are splitting day by day.Fluidity and opening of people's activities are becoming more obvious,and more and more multiplex subjects have appeared.Along with the mutual collision and shaking of the social activity factors and cultural conception,the new social relationship and the cultural conception are appearing constantly.These new social characteristics are caused by the three-dimensional culture of the social transition in contemporary China.The main body culture and realistic strength of the contemporary society of our country,stipulating inherently the contemporary society of our country,must make the transition to the development of the modernized society based on the social market economy.",
        "keywords": [
            "the contemporary China",
            "social transition",
            "cultural background",
            "characteristic"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "Philosophy Section,Party School of Shanghai Party Committee,Shanghai ,China"
            }
        ],
        "venue": "",
        "year": 2006
    },
    "DvvZSQ8x": {
        "id": "DvvZSQ8x",
        "title": "The Philosophical Reflection of Innovative Thinking System and Information Moving Process",
        "abstract": "As an information moving process,subjects' innovative thinking system can be divided into such stages as the input of external environmental information,the transformation,store and reorganization of external environmental information in the thinking system,and the output of information result.This internal thinking system is characterized by the unity of assimilation and adaptability,disorder and order,construction and deconstruction of thinking information.The information feedback of this thinking system shows the deepening of process from \"practice\" to \"understanding\".However,this feedback does not repeat or echo the original information simply and mechanically,but deepens or enriches the original information at a higher level.Thisfeedback system requires us to follow the scientific principles of appropriateness,accuracy,promptness and randomness in innovative thinking activities.",
        "keywords": [
            "philosophical reflection",
            "thinking innovation",
            "information movement"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "Department of Philosophy,Party School of the Shanghai Municipal Party Committee,Shanghai ,China"
            }
        ],
        "venue": "Journal of Foshan University(Social Science Edition)",
        "year": 2008
    },
    "pETa7QYJ": {
        "id": "pETa7QYJ",
        "title": "On the Practical Basis of Thinking Renovation",
        "abstract": "Thinking renovation is always undergoing in the process of human practice activities,in return,practice activities play a fundamentally decisive role in thinking renovation,which provide thinking renovation with important material conditions,shape the internal cognitive structure of thinking renovation and offer the open space for the development of thinking renovation,therefore,internal mechanism of interaction between new subject and new object of thinking renovation is set up and the social standard to test the new results of thinking renovation is established.",
        "keywords": [
            "basis",
            "practice",
            "thinking renovation"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "Philosophy Department,Party School of Shanghai CPC Committee,Shanghai ,China"
            },
            {
                "name": "SUN Xiao-juan",
                "org": "Philosophy Department,Party School of Shanghai CPC Committee,Shanghai ,China"
            }
        ],
        "venue": "Journal of Anhui Institute of Education",
        "year": 2006
    },
    "nV3ckbxh": {
        "id": "nV3ckbxh",
        "title": "The Systemic Thinking Characteristics of Scientific Development Concept",
        "abstract": "The contemporary systemic thinking, which is a social thinking model reflecting the inherent requirements of contemporary scientific research methodology, possesses the basic features such as opening, complexity, wholeness and coordinated development. The contemporary systemic thinking is the thinking foundation of scientific development. The scientific development concept which belongs to systemic thinking development concept fundamentally have the systemic thinking characteristics and the intensions of the times, such as the opening of development thinking, the human subject, the cause and aim of human activity, the variety of development patterns and the coordination of the whole, etc.",
        "keywords": [
            "systemic thinking",
            "characteristic",
            "scientific deelopment concept"
        ],
        "authors": [
            {
                "name": "LIU Wei-Ping",
                "org": "CCP Party School of Shanghai, Shanghai , China"
            }
        ],
        "venue": "Journal of Systemic Dialectics",
        "year": 2005
    },
    "WOFTR3z3": {
        "id": "WOFTR3z3",
        "title": "Clinical Significance of HBV-DNA Detection for Coexistent Serum Models of HBsAg and HBsAb",
        "abstract": "Objective HBV DNA copies for coexistent models of HBsAg and HbsAb were detected to discuss the application value for diagnosis and treatment of corresponding cases.Methods HBsAg,HBsAb,HBeAg,HBeAb and HBcAb were detected by ELISA and the statistical distribution of coexistent serum models of HBsAg and HBsAb were obtained.HBV DNA copies were determined for the coexistent serum samples by fluorescence quantitative PCR.Ninety-six cases of coexistent samples were divided into four groups(A,B,C,D) according to the cut off values(CO) of HBsAg and HbsAb.Results Among the coexistent models of HBsAg and HBsAb,the positive model of HBsAg,HBsAb,HBeAg and HBcAb acounted for 53.1%(51/96),and the positive model of HBsAg,HBsAb,HBeAb and HBcAb acounted for 35.4%(34/96).Besides,the positive rate of HBV DNA was 86% in HBeAg positive group and 53.1% in HBeAg negtive group,which showed significant difference(P<0.05).In HBV DNA positve samples,the logarithm value of mean HBV DNA load in HBeAg positive group was significantly higher than that in HBeAg negtive group(5.08\u00b11.12/ml vs 4.43\u00b11.15/ml,P<0.05).The positive rate of HBV DNA in group C was up to 61.5%(59/96),significantly higher than other groups.Conclusion In all coexistent serum models of HBsAg and HBsAb,the HBV DNA are supposed to be determined by fluorescence quantitative PCR to confirm whether HBV replication or not and the level of HBV load,which helps improving the accuracy of clinical diagnosis and therapeutic method.",
        "keywords": [
            "HBV DNA",
            "Hepatitis B surface antibody",
            "Hepatitis B surface antigen",
            "Fluorescence quantitative polymerase chain reaction"
        ],
        "authors": [
            {
                "name": "Liu Weiping",
                "org": ".Department of Clinical Laboratory,Zigong First People\u2032s Hospital,Sichuan ,China"
            },
            {
                "name": "Yin Minggang",
                "org": ".Department of Clinical Laboratory,Zigong First People\u2032s Hospital,Sichuan ,China"
            },
            {
                "name": "Ruan Yanqiu",
                "org": ".Department of Clinical Laboratory,Zigong First People\u2032s Hospital,Sichuan ,China"
            }
        ],
        "venue": "Journal of Medical Research",
        "year": 2012
    },
    "PkMN4nCw": {
        "id": "PkMN4nCw",
        "title": "Discussion on the value of combining detection of hemoglutination target and D-dimer",
        "abstract": "Objective To discuss the value of combining detection of hemoglutination target and D-dimmer in liver disease patients.Methods PT,APTT,TT,FIB and D-dimmer were detected for 465 cases of various types of liver disease,correlation analysis with hemoglutination target and liver function target was done.Results Hemoglutination targets were normal in acute hepatitis patients and it did not show statistically significant difference compared with control group (P> 0.05).PT,APTT,TT and D-dimmer increased in chronic hepatitis patients but FIB decreased,while compared with control group,there was significant difference (P< 0.05).The results among different types of hepatitis showed statistical difference (P< 0.05).There was negative correlation between PT and GGT,ALB,CHE,PA;negative correlation between APTT,TT and GGT,PA;as well as between FIB and TBIL,DBIL,TBA,ADA.It was positively related between PT and TBIL,DBIL,TBA,ADA;the same between APTT,TT and TBIL,DBIL,TBA,ADA;the same between FIB and GGT,PA;the same between D-dimmer and TBIL,DBIL,ADA (P< 0.05).Conclusion Combination detection of PT,APTT,TT,FIB and D-dimmer in liver disease patients has great value in diagnosis and treatment,especially in chronic hepatitis.Combining analysis with liver function target would be good to liver disease patients' diagnosis,different diagnosis,course monitoring,prognosis judgment and therapeutic effect observation.",
        "keywords": [
            "D-dimmer",
            "Hemoglutination target",
            "Liver disease",
            "Liver function target"
        ],
        "authors": [
            {
                "name": "ZHONG Huixiu",
                "org": " Department of Clinical Laboratory,the First Hospital of Zigong City in Sichuan Province,Zigong ,China"
            },
            {
                "name": "YIN Minggang",
                "org": " Department of Clinical Laboratory,the First Hospital of Zigong City in Sichuan Province,Zigong ,China"
            },
            {
                "name": "LIU Weiping",
                "org": " Department of Clinical Laboratory,the First Hospital of Zigong City in Sichuan Province,Zigong ,China"
            }
        ],
        "venue": "China Modern Medicine",
        "year": 2012
    },
    "qrnHw1jD": {
        "id": "qrnHw1jD",
        "title": "Study on Co-detection of HBV Serum Immunological Markers,Pre-S1 and HBV DNA",
        "abstract": "Objective To investigate the correlation among HBV infection models,HBV Pre-S1 antigen and HBV DNA loads in serum and to provide evidence for the diagnosis and treatment of hepatitis B.Methods Hepatitis B markers,HBV Pre-S1 antigen and HBV DNA loads in serum samples were detected simultaneously for 1037 cases.Results The positive rate of HBV Pre-S1 antigen was higher in HBsAg,HBeAg and HBcAb positive model than that in other models(P<0.05).Besides,the positive rate of HBV DNA was higher in HBsAg,HBeAg and HBcAb positive model than that in other models(P<0.05).Furthermore,the HBV load was higher in HBsAg,HBeAg and HBcAb positive model than that in HBsAg,HBeAb and HBcAb positive model(P<0.05).The results of HBV load showed no significant differences between HBsAg,HBeAb and HBcAb positive model and HBsAg,HBcAb positive model(P>0.05).Conclusion The quantitative detection of HBV DNA is important for the prevention of HBV infection.The combination assay of serum HBV markers,Pre-S1 antigen and HBV DNA load was beneficial to the monitoring of disease condition of hepatitis B and to the improvement of therapeutic effect.",
        "keywords": [
            "HBV DNA",
            "Hepatitis B virus",
            "Fluorescence quantitative PCR",
            "Pre-S1 antigen of HBV"
        ],
        "authors": [
            {
                "name": "Liu Weiping",
                "org": ".Zigong First People\u2032s Hospital in Sichuan Province,Sichuan,,China"
            },
            {
                "name": "Yin Minggang",
                "org": ".Zigong First People\u2032s Hospital in Sichuan Province,Sichuan,,China"
            },
            {
                "name": "Ma Shengyu",
                "org": ".Zigong First People\u2032s Hospital in Sichuan Province,Sichuan,,China"
            }
        ],
        "venue": "Journal of Medical Research",
        "year": 2010
    },
    "vKdrRzSs": {
        "id": "vKdrRzSs",
        "title": "Study on the interference factors of detection of WBC,RBC,CAST by UF-100 urinary sediment analyzer",
        "abstract": "Objective To discuss the interference factors of detection of WBC,RBC,CAST by UF-100 urinary sediment analyzer.Methods 8 950 cases of midpiece morning urine samples were dectected by UF-100 urinary sediment analyzer and compared with manual microscopy.Results The main false positive factor of detection for WBC,RBC,CAST was ammonium salts(accounts for 35.3%),calcium oxalate crystals(accounts for 40.1%),and viscose rayon(accounts for 38.1%) respectively.The main false negative factor of detection for WBC,RBC,CAST was WBC accumulation(accounts for 59.2%),shadow RBC(accounts for 34.5%) and hyaline cast(accounts for 100.0%) respectively.Conclusion Many interference factors exist in urine for detection of WBC,RBC,CAST by UF-100 urinary sediment analyzer.Therefore,microscopy review standards and result verifying system are supposed to be established to avoid clinical misdiagnosis and mistreatment.",
        "keywords": [
            "False negative",
            "False positive",
            "Microscopy",
            "Urinary sediment analyzer"
        ],
        "authors": [
            {
                "name": "LIU Weiping",
                "org": " Laboratory Department of Zigong First People's Hospital in Sichuan Province,Zigong ,China"
            },
            {
                "name": "YIN Minggang",
                "org": " Laboratory Department of Zigong First People's Hospital in Sichuan Province,Zigong ,China"
            },
            {
                "name": "ZHONG Huixiu",
                "org": " Laboratory Department of Zigong First People's Hospital in Sichuan Province,Zigong ,China"
            }
        ],
        "venue": "China Modern Medicine",
        "year": 2012
    },
    "3i8yNhDG": {
        "id": "3i8yNhDG",
        "title": "Discussion on the Relationship between Peripheral Blood Atypical Lymphocyte Information from Sysmex XT-2000i and EBV-VCA IgM Antibody.",
        "abstract": "Objective To discuss the relationship between peripheral blood atypical lymphocyte and EBV-VCA IgM antibody.Methods A total of 400 cases were with atypical lymphocyte information from Sysmex XT-2000i automated hematology analyzer.EDTA anti-coagulation and serum samples were collected from them for Wright's staining microscopy and testing EBV-VCA IgM antibody by ELISA,respectively.Results In the 400 cases with atypical lymphocyte information,291 cases were positive confirmed by microscopy,and EBV-VCA IgM positive rate was 86.9%,which was significantly higher than that in negative cases(n = 109) by microscopy(29.4%)(P <0.01).According to the percentage of atypical lymphocyte(1% ~10%,10% ~20%,>20%),they were divided into three groups.EBV-VCA IgM positive rates were 10.8%,49.4% and 82.2%,respectively,which showed significant difference(P<0.01).According to morphological types of atypical lymphocytes,they were divided into the simple one,two hybrid and three mixed group.EBV-VCA IgM positive rate in the three group were 12.4%,42.1% and 86.0%,respectively,which also showed significant difference(P<0.01).Conclusion The atypical lymphocyte information from Sysmex XT-2000i has important value and it can be used as a screening indicator.EBV-VCA IgM positive rate tended to increase with the percentage of atypical lymphocytes.And it was also positively correlated with the number of morphological types of atypical lymphocyte.",
        "keywords": [
            "Sysmex XT-2000i",
            "Atypical lymphocyte",
            "EBV-VCA IgM"
        ],
        "authors": [
            {
                "name": "Liu Weiping",
                "org": ""
            },
            {
                "name": "Yu Mei",
                "org": ""
            },
            {
                "name": "Yin Minggang",
                "org": ""
            }
        ],
        "venue": "Journal of Medical Research",
        "year": 2013
    },
    "vzFBbDnn": {
        "id": "vzFBbDnn",
        "title": "Gingival figuration enhanced by light-cure resin around dental implants",
        "abstract": "The paper reports the use of light-cured resin molding finished implant healing abutment,forming secondary gum,to enhance the aesthetic effect.Satisfactory aesthetic results were obtained in 18 patients immediately after wearing denture and 3 months after treatment.The light-cured resin molding clinical gingival healing abutment is simple and feasible.",
        "keywords": [
            "Gingiva",
            "Light-cure resin",
            "Esthetics",
            "Implant denture"
        ],
        "authors": [
            {
                "name": "WU Wangxi",
                "org": ".,Guangdong Provincial Stomatology Hospital,The Affiliated Stomatology Hospital of Southern Medical University,China"
            },
            {
                "name": "XU Shulan",
                "org": ".,Guangdong Provincial Stomatology Hospital,The Affiliated Stomatology Hospital of Southern Medical University,China"
            },
            {
                "name": "ZHOU Lei",
                "org": ".,Guangdong Provincial Stomatology Hospital,The Affiliated Stomatology Hospital of Southern Medical University,China"
            },
            {
                "name": "LIU Weiping",
                "org": ".,Guangdong Provincial Stomatology Hospital,The Affiliated Stomatology Hospital of Southern Medical University,China"
            },
            {
                "name": "ZHANG Xueyang",
                "org": ".,Guangdong Provincial Stomatology Hospital,The Affiliated Stomatology Hospital of Southern Medical University,China"
            },
            {
                "name": "CHEN Zhusu",
                "org": ".,Guangdong Provincial Stomatology Hospital,The Affiliated Stomatology Hospital of Southern Medical University,China"
            }
        ],
        "venue": "Journal of Practical Stomatology",
        "year": 2011
    },
    "A9RTRWrh": {
        "id": "A9RTRWrh",
        "title": "Clinical evaluation of dental implant treatment for borderline small edentulous space in aesthetic zone",
        "abstract": "ObjectiveTo evaluate the clinical effects of dental implant treatment for small edentulous space in aesthetic zone.MethodsSeven adult patients with about 6 mm edentulous space in aesthetic zone were restored with single crowns.All missing teeth were replaced by 3.5 mm diameter dental implants with taper and thread shape.Provisional restoration was used before final crown.ResultsSeven cases obtained stable functional and aesthetic results by oral checking and X-ray within average 24 months follow-up.ConclusionDental implant treatment for small edentulous space in aesthetic zone can get acceptable clinical result in short term.",
        "keywords": [
            "Aesthetic",
            "Small space",
            "Dental implant",
            "Restoration"
        ],
        "authors": [
            {
                "name": "WU Wang-xi",
                "org": ".Department of Implantology,Guangdong Provincial Stomatological Hospital & the Affiliated Stomatological Hospital of Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "MENG Bo",
                "org": ".Department of Implantology,Guangdong Provincial Stomatological Hospital & the Affiliated Stomatological Hospital of Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": ".Department of Implantology,Guangdong Provincial Stomatological Hospital & the Affiliated Stomatological Hospital of Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Journal of Dental Prevention and Treatment",
        "year": 2013
    },
    "yiybRwgt": {
        "id": "yiybRwgt",
        "title": "Experimental Study on the Influence of Soybean Isoflavone to Femoral Bone Defect Repairing Ability in Ovariectomized Rats",
        "abstract": "Objective To study the influence of soybean isoflavone(SIF)to osteogenic efficiency of decalcified freeze-dried bone implanted into the calvarial defects of ovariectomized rats.Methods Decalcified freeze-dried bone were created.Twenty female SD rats were randomly divided into two groups.The ovaries were excised to ensure the formation of postmenopausal osteoporosis.A defect was created in femur and decalcified freeze-dried bone was implanted into the defect of all rats.The rats in SIF group were treated by i.g 100 mg/kg daily and the rats in control group were treated by normao saline for 8 weeks.The rats were scarified according schedule.The new bone forming capability of decalcified freeze-dried bone was evaluated with undecalcified histological observation and tetracycline-fluorescence-marker.Results New bone formed within the bone defects in both groups.Compared to the control group,the new bone formation activity and abundant bone trabecula cross-linked were more obvious.The mineralization of callus in control group was lower.Conclusion Soybean isoflavone increased osteogenic effciency of decalcified freeze-dried bone implanted into the calvarial defects of ovariectomized rats,suggesting that SIF could play an important role in bone remodeling with bone substitute clinically.",
        "keywords": [
            "Soybean isoflavone",
            "Bone defect",
            "Freeze-dried demineralized bone matrix",
            "Osteoporosis"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": ",et al.1Guangdong Provincial Stomatological Hospital & the Affiliated Stomatological Hospital of Southern Medical University,Guanghzou ,China"
            },
            {
                "name": "WU Y",
                "org": ",et al.1Guangdong Provincial Stomatological Hospital & the Affiliated Stomatological Hospital of Southern Medical University,Guanghzou ,China"
            },
            {
                "name": "DONG Yi",
                "org": ",et al.1Guangdong Provincial Stomatological Hospital & the Affiliated Stomatological Hospital of Southern Medical University,Guanghzou ,China"
            }
        ],
        "venue": "Journal of Dental Prevention and Treatment",
        "year": 2010
    },
    "I8D2tAMf": {
        "id": "I8D2tAMf",
        "title": "Investigation on Maxillary Sinus Floor Lifting with Simultaneous Placement of Implants",
        "abstract": "Objective To investigate the effect of sinus floor elevation for immediate implantation.Methods16 maxillary sinus underwent sinus floor lifting and simultaneous 28 implants placement.ResultsThe average lifting height is 11.8 mm,16 patients had been restorated.In the mean time of follow up of 10 months,there were no implant loose or lost,and masticatory function was normal.ConclusionMaxillary Sinus floor lifting with simultaneous implants placement is predictable.",
        "keywords": [
            "Simultaneous",
            "Bone condensing",
            "Maxillary sinus lifting",
            "Residual ridge height"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": ".Guangdong Provincial Stomatological Hospital\u00b7the Affiliated Stomatological Hospital of Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "WU Wang-xi",
                "org": ".Guangdong Provincial Stomatological Hospital\u00b7the Affiliated Stomatological Hospital of Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "WANG Chun-xian",
                "org": ".Guangdong Provincial Stomatological Hospital\u00b7the Affiliated Stomatological Hospital of Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Journal of Dental Prevention and Treatment",
        "year": 2009
    },
    "75d1o1uP": {
        "id": "75d1o1uP",
        "title": "Research of Peri-implantal Tissue Health in Partially Edentulous Patients with Chronic Periodontitis",
        "abstract": "Objective To investigate the effects of chronic periodontitis on peri-implantal tissue health by comparing with healthy partially edentulous patients.Methods 20 dental implants were operated on healthy group and chronic periodontitis group separately.Six months later after restoration,modified plaque index,modified sulcus bleeding index,probing depth and marginal bone loss were scored in an standard manner.Results There was no significant difference between healthy group and chronic periodontitis group,regarding all the indices observed.Conclusion Reliable effect can be achieved when ITI implant system is used on controllable chronic periodontitis patients.However,long-term effects need to be observed in the future.",
        "keywords": [
            "Peri-implantal tissue",
            "Chronic periodontitis",
            "Partially edentulous"
        ],
        "authors": [
            {
                "name": "ZHANG Xue-yang",
                "org": ".Center of Implantology,Guangdong Provincial Stomatologic Hospital\u00b7Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": ".Center of Implantology,Guangdong Provincial Stomatologic Hospital\u00b7Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "YU Yan-ling",
                "org": ".Center of Implantology,Guangdong Provincial Stomatologic Hospital\u00b7Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Journal of Dental Prevention and Treatment",
        "year": 2008
    },
    "GH0M80vv": {
        "id": "GH0M80vv",
        "title": "Optimization of pure titanium dome with self-tapping threads on rabbit calvarial bone surface: an experimental animal model",
        "abstract": "Objective To establish the experimental model of the optimized pure titanium dome with self-tapping threads on rabbit calvarial bone surface. Methods The prefabricated pure titanium domes, with inner empty hemispherical shape, was performed by special precision machine tool, added some self-tapping threads on the root of the domes and two circular small holes on the top (diameter 0.8 mm). All the inner surface of the pure titanium domes had the same basic form and topography. Fourty-eight pure titanium domes were placed in calvarial bone surface of twelve healthy New Zealand rabbits. The animals were sacrificed at 2nd week, 4th week and 6 th week after the placement of pure titanium dome. The stability of the pure titanium domes were investigated by general observation and Micro CT scanning. Various histomorphometric observations were performed in the central of the undecalcified sections. Results The stability of the forty-eight pure titanium domes were excellent at 2nd week, 4 th week and 6th week when the rabbits were scarified. Only 2 were less fixable at the initial placing process with loose rate 4.17% in general observation. The Micro CT showed that all the pure titanium domes were fixed well on rabbit calvarial bone space. The results of the undecalcified sections showed that the bone tissue around the bottom of the pure titanium dome grew into the thread, which indicated the stability of the domes in different times. The pure titanium domes with self-tapping thread was helpful for distinction of new bone tissue growth. Conclusion The design of the pure titanium dome with self-trapping screw is less complicate than the traditional ones. The self-trapping screws do help to increase the stability of the pure titanium domes.The application of the pure domes with self-trapping screws on rabbit calvarial bone surface reduces the surgical trauma and simplify the operation steps, improve the efficiency, which was more objective and reliable to reflect implant biocompatibility and bone response. The optimized pure titanium dome with self-trapping screw is a kind of application prospect in animal experimental model for implant surface treatment.",
        "keywords": [
            "Surface treatment",
            "Animal experimental model",
            "Self-trapping implant",
            "Titanium dome"
        ],
        "authors": [
            {
                "name": "LIU Wei-zhen",
                "org": ". Department of Implantology, the Affiliated Stomatological Hospital of Southern MedicalUniversity & Guangdong Provincial Stomatological Hospital, Guangzhou , China"
            },
            {
                "name": "ZHOU Lei",
                "org": ". Department of Implantology, the Affiliated Stomatological Hospital of Southern MedicalUniversity & Guangdong Provincial Stomatological Hospital, Guangzhou , China"
            },
            {
                "name": "DING Jing-wen",
                "org": ". Department of Implantology, the Affiliated Stomatological Hospital of Southern MedicalUniversity & Guangdong Provincial Stomatological Hospital, Guangzhou , China"
            },
            {
                "name": "GUO Ze-hong",
                "org": ". Department of Implantology, the Affiliated Stomatological Hospital of Southern MedicalUniversity & Guangdong Provincial Stomatological Hospital, Guangzhou , China"
            },
            {
                "name": "GAO Yan",
                "org": ". Department of Implantology, the Affiliated Stomatological Hospital of Southern MedicalUniversity & Guangdong Provincial Stomatological Hospital, Guangzhou , China"
            },
            {
                "name": "LAI Chun-hua",
                "org": ". Department of Implantology, the Affiliated Stomatological Hospital of Southern MedicalUniversity & Guangdong Provincial Stomatological Hospital, Guangzhou , China"
            },
            {
                "name": "RONG Ming-deng",
                "org": ". Department of Implantology, the Affiliated Stomatological Hospital of Southern MedicalUniversity & Guangdong Provincial Stomatological Hospital, Guangzhou , China"
            },
            {
                "name": "LIU Wei-ping",
                "org": ". Department of Implantology, the Affiliated Stomatological Hospital of Southern MedicalUniversity & Guangdong Provincial Stomatological Hospital, Guangzhou , China"
            },
            {
                "name": "LIN Xi",
                "org": ". Department of Implantology, the Affiliated Stomatological Hospital of Southern MedicalUniversity & Guangdong Provincial Stomatological Hospital, Guangzhou , China"
            }
        ],
        "venue": "Journal of Dental Prevention and Treatment",
        "year": 2013
    },
    "izFH3XvR": {
        "id": "izFH3XvR",
        "title": "The design and implementation of fault management system for EPON",
        "abstract": "Intensively analyzed the function and key technology.The fault management scheme of EPON system based on the SNMP protocol and the structure of B/S was designed and implemented with the technology of java, jsp and Oracle, which completes the functions such as monitoring, storage and query of fault alarm information.Finally, the performance of fault management system was tested and analyzed.",
        "keywords": [
            "SNMP",
            "alarm information",
            "EPON",
            "fault information"
        ],
        "authors": [
            {
                "name": "LIN Yong-bang",
                "org": "Department of Electronic and Engineering, Jinan University, Guangzhou ,China;Key Laboratory of Optical Fiber Communication and Sensing Technology, Jinan University, Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronic and Engineering, Jinan University, Guangzhou ,China;Key Laboratory of Optical Fiber Communication and Sensing Technology, Jinan University, Guangzhou ,China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Department of Electronic and Engineering, Jinan University, Guangzhou ,China;Key Laboratory of Optical Fiber Communication and Sensing Technology, Jinan University, Guangzhou ,China"
            },
            {
                "name": "WU Jin-Feng",
                "org": "Department of Electronic and Engineering, Jinan University, Guangzhou ,China;Key Laboratory of Optical Fiber Communication and Sensing Technology, Jinan University, Guangzhou ,China"
            }
        ],
        "venue": "Optical Communication Technology",
        "year": 2009
    },
    "Xn4qdunz": {
        "id": "Xn4qdunz",
        "title": "The LinkSec Protocol in EPON",
        "abstract": "The security threats in EPON are analyzed briefly,the link security protocol for link security is investigated,and the current LinkSec models and the function of their components are comprehensively introduced.And on this basis the scheme for key division and update is improved.This scheme uses MPCP frame as the encryption counter and reduces the generated cycle of the key,so that can rationally solve the security problem in EPON.",
        "keywords": [
            "AES",
            "MACSec",
            "link security",
            "EPON"
        ],
        "authors": [
            {
                "name": "ZHONG Cui",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "CHEN Shun-er",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Optical Fiber & Electric Cable and Their Applications",
        "year": 2009
    },
    "DdqmyLRu": {
        "id": "DdqmyLRu",
        "title": "Communication interface designed based on wireless transmission system using visible light",
        "abstract": "The scheme of video wireless transmission system using visible light was proposed. And base on the proposed scheme, the design of video communication interface, which include video capture, video sending,the communication of USB interface, video receiving and video display, was presented. The detailed methods of design and implementation were introduced. At last, the debugging results of the design were shown to demonstrate that the proposed design is feasibility and validity.",
        "keywords": [
            "visible light communication",
            "CH376S",
            "video transmission system",
            "USB communication interface",
            "FPGA"
        ],
        "authors": [
            {
                "name": "CHEN Jiao-rong",
                "org": ""
            },
            {
                "name": "HUANG Hong-bin",
                "org": ""
            },
            {
                "name": "LIU Wei-ping",
                "org": ""
            }
        ],
        "venue": "Optical Communication Technology",
        "year": 2013
    },
    "ku7nyKaQ": {
        "id": "ku7nyKaQ",
        "title": "Research and realization of telephone conference system based on packet forwarding",
        "abstract": "According to the popularization tendency of telephone conference system and the problems existed in present telephone con-ference,it is presented and designed a new implementation method of telephone conference named telephone conference technology based on packet forwarding,in which the voice and signaling datum are transmitted to other ends transparently without being any pro-cessed.A telephone conference system based on PSTN signal technology and Ethernet technology is designed and implemented.The tested results show that the designed system can realize the basic function of telephone conference systems.",
        "keywords": [
            "telephone conference",
            "PSTN",
            "communication protocols",
            "packet forwarding technology",
            "WinPcap technology",
            "FastTran",
            "No7 signaling"
        ],
        "authors": [
            {
                "name": "CHEN Shun-er",
                "org": "Department of Electric,Jinan University,Guangzhou ,China"
            },
            {
                "name": "HUANG Zhi-hong",
                "org": "Modern Education Technology Center,Agriculture University of South China,Guangzhou ,China"
            },
            {
                "name": "ZHOU Chu-wen",
                "org": "Department of Electric,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LI Xi-ming",
                "org": "Modern Education Technology Center,Agriculture University of South China,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electric,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Computer Engineering and Design",
        "year": 2008
    },
    "55CmZkO3": {
        "id": "55CmZkO3",
        "title": "The design and implementation of EPON performance management system based on Web",
        "abstract": "This paper designed the system pattern and the logical architecture which is based on web,described realization flow of system in detail and implemented with JAVA language,JSP technology and Oracle database technology,which achieves the functions such as network performance,monitor and performance information processing.Finally the performance management system was tested and analyzed.",
        "keywords": [
            "performance management",
            "Web",
            "EPON"
        ],
        "authors": [
            {
                "name": "FENG Xian-zheng",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "XIE Hai-ming",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIN Yong-bang",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Opto-electronic and Fiber Sensing Institute of Beijing Pioptics,Beijing ,China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Optical Communication Technology",
        "year": 2010
    },
    "lZaCFmaz": {
        "id": "lZaCFmaz",
        "title": "Design and implementation of embedded video monitoring transmission system",
        "abstract": "The design and implementation of H.264 video monitoring transmission system are introduced.The starting code of NALU in video compressed data at Davinci platform is searched thought the NAL unit distilled module,then pushes video data to RTP thread as load.And in order to get the balance of quality of video and the bandwidth of net,rate control module is added to adjust the rate of video coding and sending based on the information of the SR and RR packet.",
        "keywords": [
            "H.264",
            "real-time transport protocol",
            "Davinci",
            "real-time transport control protocol",
            "embedded Linux"
        ],
        "authors": [
            {
                "name": "ZHANG Duo-ying",
                "org": "Department of Electronics Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "SHEN Chen",
                "org": "Department of Electronics Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronics Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Department of Electronics Engineering,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Computer Engineering and Design",
        "year": 2010
    },
    "3dk3Z77U": {
        "id": "3dk3Z77U",
        "title": "Design and Implement of VGA Display Dynamically Controller Based on FPGA",
        "abstract": "According to the principle of VGA,a controller of VGA display dynamically system based on FPGA is designed in this paper.The algorithm is implemented in Verilog HDL,and is accomplished by Xilinx ISE 7.1i of the Xilinx company.The designed controller is tested with the system.It shows that the controller can operate properly.",
        "keywords": [
            "Verilog HDL",
            "sequence signal",
            "VGA",
            "FPGA"
        ],
        "authors": [
            {
                "name": "LIAO Yongqing",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "DING Xuchang",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "FU Jianguo",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Weiping",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Video Engineering",
        "year": 2011
    },
    "AIdprNmN": {
        "id": "AIdprNmN",
        "title": "Design of voice value-added service platform based on NGN model",
        "abstract": "A new type of voice value-added service platform,which is named VAS_InfoX platform and referring to NGN(next generation network)model,is designed for the following purposes:Firstly,new services are put out in the market in a short time while integrated with the using services.Secondly,the investment cost and risks of new services are reduced greatly.The architecture of VAS_InfoX platform,which includes two set of architectures,namely prophase and anaphase architecture respectively,is designed to own the features of service independence and extensible resource.The scale ofprophase architecture is comparatively small while anaphase archi- tecture can embody the advantages of NGN model.In order to guarantee the platform's stability,a couple of CTI server is used to share the burden with the collaboration of software system used for updating the database server synchronously.In addition,the opinion that trunk resource can be controllable and supervised is proposed with the intention of reducing the investment cost of service provider(SP) while boosting the trunk resource efficiency oftelecom carrier.VAS_InfoX platform is forcast to have a nice market perspective and high research value.",
        "keywords": [
            "VAS_InfoX platform",
            "NGN model",
            "trunk resource controllable and supervised",
            "SP",
            "voice value-added service"
        ],
        "authors": [
            {
                "name": "XIE Qi-liang",
                "org": "Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Jinan University,Guangzhou ,China"
            },
            {
                "name": "YU Xi-chang",
                "org": "Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Computer Engineering and Design",
        "year": 2007
    },
    "hzAqHNwM": {
        "id": "hzAqHNwM",
        "title": "An improved DBA method for WDM-EPON",
        "abstract": "A kind of dynamic bandwidth allocation(DBA) algorithms of WDM-EPON which provides a promising upgrade scenario for current single-channel TDM based EPON was studied and improved. Wavelengths and bandwidth are distributed according to the services types in ONU by the advanced DBA algorithms in order to guarantee the QoS of the miltiple-services access,making the whole network bandwidth allocation fair and efficient. The simulation results based on OPNET indicates that the improved DBA algorithms performed well in successful QoS assurance of bandwidth and time delay for the different priority services.",
        "keywords": [
            "QoS",
            "WDM-EPON",
            "OPNET",
            "dynamic bandwidth allocation"
        ],
        "authors": [
            {
                "name": "ZENG Zhi-wei",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "RAN Yang",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Optical Communication Technology",
        "year": 2009
    },
    "ckLhnljt": {
        "id": "ckLhnljt",
        "title": "SoC-based FBG Temperature Sensor",
        "abstract": "Accurately measuring the shift of wavelength is the key technique for sensors based on fiber Bragg grating(FBG).A FBG temperature sensor based on SoC is designed,the wavelength of FBG reflected spectrum is tracked through controlling the wavelength of the laser,thereby realizing the demodulation of temperature sensor.The system is of high SNR,good reliability,low cost,simple hardware,flexible software,intelligence,etc.,and has good prospect in applications and development.",
        "keywords": [
            "demodulation",
            "sensor technique",
            "SoC",
            "fiber Bragg grating"
        ],
        "authors": [
            {
                "name": "CAI Jun",
                "org": "Department of Electronic Information Engineering,Guangdong Polytechnic Normal University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronic Engineering,College of Informational Science and Technology,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Optical Fiber & Electric Cable and Their Applications",
        "year": 2007
    },
    "5gIT0R7k": {
        "id": "5gIT0R7k",
        "title": "The research and scheme of WDM-PON technology",
        "abstract": "The system structure and working principle of WDM-PON is briefly introduced.Comparatively an-alyzed technical advantages of WDM-PON,and intensively investigated the colorless ONU technology as well as Hybrid WDM/TDM-PON technology of WDM-PON.By integrating both of the technology,a innova-tive scheme was proposed.Thise schemes,which support various advanced network services,provide a good referrence for future WDM-PON access network system.",
        "keywords": [
            "PON",
            "colorless ONU",
            "WDM-PON"
        ],
        "authors": [
            {
                "name": "LIN Yong-bang",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "CHEN Shun-er",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Optical Communication Technology",
        "year": 2009
    },
    "n56Qk28u": {
        "id": "n56Qk28u",
        "title": "Telephone switching system in ethernet based on FastTran",
        "abstract": "A telephone switching system in Ethernet basedon FastTran is introduced,which implements the function of signal transferring fast from PSTN to LAN.Accordingly,the switching matrix in traditional exchanger can be substituted by the system.In this system a common personal computer is acted as switching server,and the No.7 signaling can be analyzed and operated in the server.Thus the dialing and voice communication from common personal computer to telephone and among personal computers can be carried out.",
        "keywords": [
            "switching server",
            "ethernet",
            "No.7 signaling",
            "fasttran"
        ],
        "authors": [
            {
                "name": "XU Shu-jun",
                "org": "Department of Electric,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electric,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LI Xi-ming",
                "org": "Network Ministry of Modern Education and Technology Center,Agriculture University of South China,Guangzhou ,China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Department of Electric,Jinan University,Guangzhou ,China"
            },
            {
                "name": "CHEN Shun-er",
                "org": "Department of Electric,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Computer Engineering and Design",
        "year": 2005
    },
    "agTI5z7G": {
        "id": "agTI5z7G",
        "title": "Design and implementation of topology management in EPON networks management system",
        "abstract": "Importance of topology management is explained in the paper.In order to manage the EPON networks system more easily,the design scheme of topology management based on b/s structure of EPON network management is proposed.Through the test,with Trap initiative reporting function,hierarchical network topology diagrams are displayed quickly and accurately,the topology management capabilities are implemented,and the actual need of the project is met.",
        "keywords": [
            "topology management",
            "networks management",
            "Ethernet passive optical network"
        ],
        "authors": [
            {
                "name": "WANG Hong-qin",
                "org": "Department of Electronics Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Department of Electronics Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronics Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "NIE Jing",
                "org": "Department of Electronics Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "XU Hong",
                "org": "Department of Electronics Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Optical Communication Technology",
        "year": 2010
    },
    "j6RxBOSz": {
        "id": "j6RxBOSz",
        "title": "Design of embedded portable OTDR system",
        "abstract": "According to the structure and characteristic of metropolitan area network,using the basic principle of OTDR,this paper introduces a portable OTDR system based on the ARM,FPGA and high speed A/D converter.The system uses FPGA to design a special hardware circuit for digital accumulator and average,controls the high speed A/D converter to collect data,and the measure time compares to other products shorts a quantitatively level.This design has the advantages of low power consumption,low cost and short test time.",
        "keywords": [
            "portable",
            "digital cumulative average",
            "OTDR"
        ],
        "authors": [
            {
                "name": "WANG Liang",
                "org": ""
            },
            {
                "name": "HUANG Hong-bin",
                "org": ""
            },
            {
                "name": "LIU Wei-ping",
                "org": ""
            },
            {
                "name": "CHEN Shun-er",
                "org": ""
            }
        ],
        "venue": "Optical Communication Technology",
        "year": 2013
    },
    "5qCCCyDB": {
        "id": "5qCCCyDB",
        "title": "The research and scheme of 10G GPON technology",
        "abstract": "The system structure and working principle of 10G GPON is briefly introduced.Comparatively analyzed technical advantages of 10G GPON,and intensively investigated the system updating process of GPON to 10G GPON as well as the critical technology of symmetrical 10G GPON.At last a innovative scheme of 10G GPON was proposed.Thise schemes,which is compatible with the existing GPON,and with 10Gbps upstream and downstream.It provide a good referrence for future 10G GPON access network system.",
        "keywords": [
            "10G GPON",
            "hybrid system",
            "PON"
        ],
        "authors": [
            {
                "name": "PAN Zhi-hong",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIN Yong-bang",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Optical Communication Technology",
        "year": 2010
    },
    "a4LDfgUC": {
        "id": "a4LDfgUC",
        "title": "Design and Implementation of GIS in the LBS Platform",
        "abstract": "As the emergence and rapid development trend of location-based services business,the GIS system in the internet-based location service platform is designed and implemented.The GIS system takes \"MapXtreme for Java\" as its core,and is achieved in compliance with the four-layer structure of the thin-client,which is mainly focused on the design and exploitation of functional modules,such as map display,mobile terminal location,map control,related inquiries,geocoding and reverse geocoding,and the GIS subsystem is successfully transplanted into the LBS platform by using packaging.The whole system is totally realized by Java,and has good portability.",
        "keywords": [
            "GIS WebGIS MapXtreme for Java LBS"
        ],
        "authors": [
            {
                "name": "QI Pan",
                "org": "Department of Electronics Engineering,Guangdong Communication Polytechnic,Guangzhou "
            },
            {
                "name": "CAI Jun",
                "org": "Department of Electronics Engineering1,Guangdong Polytechnic Normal University,Guangzhou,"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronics Engineering2,Jinan University,Guangzhou ,P.R.China"
            }
        ],
        "venue": "Science Technology and Engineering",
        "year": 2009
    },
    "cZQ26LCY": {
        "id": "cZQ26LCY",
        "title": "A Novel Design of OCDMA System and Its Application in PON",
        "abstract": "Through research on the operation principle of FFH-OCDMA and TCM,a novel en-decoder scheme of OCDMA is proposed in this paper to reduce multiple access interference in OCDMA system.The related application of this scheme in PON is discussed also.",
        "keywords": [
            "PON",
            "TCM",
            "FFH-OCDMA"
        ],
        "authors": [
            {
                "name": "GUAN Rui-xiong",
                "org": "Dept.of MEE,Guangdong Polytechnic College,Guangzhou ,China"
            },
            {
                "name": "FANG Jun-bin",
                "org": "Dept.of Electronic Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Dept.of Electronic Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "CHEN Shun-er",
                "org": "Dept.of Electronic Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Dept.of Electronic Engineering,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Optical Fiber & Electric Cable and Their Applications",
        "year": 2006
    },
    "QXjtExMD": {
        "id": "QXjtExMD",
        "title": "The Design and Implementation of Data Communication System Based on Lab VIEW",
        "abstract": "Data communication is one of the most important aspects of virtual instrument's design.Virtual instrument's design always needs real-time data communication.The paper introduces some technologies of data communication,such as Datasocket,TCP/IP protocol and FTP protocol,etc,which focus on the FTP communication technology.It designs the FTP transfer technology bases on folder in the light of library functions of NI Lab VIEW,and it is used in data transfer subsystem of bridge health monitor system,fast file transfer was realized.Finally the system was tested and analyzed..",
        "keywords": [
            "data transmission system",
            "data communication",
            "FTP",
            "datasocket",
            "Lab VIEW"
        ],
        "authors": [
            {
                "name": "ZHONG Xiangrui",
                "org": "1Department of Computer Information,Guangdong Polytechnic College,Guangzhou ,China, "
            },
            {
                "name": "XIE Haiming",
                "org": "2Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Weiping",
                "org": "2Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Microcomputer Applications",
        "year": 2011
    },
    "p6PVijK0": {
        "id": "p6PVijK0",
        "title": "Research and Realization of WebGIS Spatial Data",
        "abstract": "The GIS Data was investigated,and the way of spatial data management. Object-relation model of database that based on Oracle Spatial was established. The storage,management,and sharing of data in the WebGIS database was realized. The test result showed that the running of the database was accurate and reliable. The database has good practicability and can be widely used.",
        "keywords": [
            "WebGIS",
            "Oracle Spatial",
            "Spatial Data",
            "Spatial Database",
            "GIS"
        ],
        "authors": [
            {
                "name": "QI Pan",
                "org": "Department of Electronics Engineering,Guangdong Communication Polytechnic,Guangzhou Guangdong "
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronics Engineering,Jinan University,Guangzhou Guangdong "
            }
        ],
        "venue": "Science & Technology Information",
        "year": 2009
    },
    "8evoueY8": {
        "id": "8evoueY8",
        "title": "Design and Implementation of LBS Platform Based on J2EE",
        "abstract": "Based on the rapid development of Location Based Service(LBS),and realized LBS platform based on J2EE is investigated.This platform adopted open source J2EE framework.The division of all sub-modules,the interface function,and user protocol of the LBS platform were planed and designed.The sub-modules of user request integrated processing,user authentication management,GIS adopter layer,and background management were realized.The platform is tested in both Web and Wap environment,and the result show that the platform could run well.",
        "keywords": [
            "WAP",
            "location based service open source interface function protocol",
            "EJB",
            "J2EE",
            "GIS Adapter Layer",
            "LBS Platform"
        ],
        "authors": [
            {
                "name": "QI Pan",
                "org": "Department of Electronics Engineering,Guangdong Communication Polytechnic,Guangzhou ,P.R.China"
            },
            {
                "name": "HUANG Jia-ming",
                "org": "Zhongxing Telecommunication Equipment Corporation1,Shenzhen ,P.R.China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronics Engineering,Jinan University2,Guangzhou ,P.R.China"
            }
        ],
        "venue": "Science Technology and Engineering",
        "year": 2009
    },
    "Fz0qjRcE": {
        "id": "Fz0qjRcE",
        "title": "Metro ethernet and its new standard",
        "abstract": "As one of the main technologies of metropolitan area network,metro ethernet develops quite rapidly.A new metro ethernet standard\u2014carrier ethernet is carried ont,which accelerates the development of metro ethernet.Based on analyzing the existent metro ethernet and the disadvantages which counterwork the ethernet to upgrade to carrier ethernet,including service model,end to end QoS,protection principle,operation,administration,maintenance,etc,the solution is given out according to analyze the disadvantage detailedly based on the MEF carrier ethernet.The development of carrier ethernet is expected to afford reference for carrying the new standard into execution.",
        "keywords": [
            "QoS",
            "OAM",
            "ethernet",
            "metropolitan area network",
            "carrier ethernet"
        ],
        "authors": [
            {
                "name": "JIANG Dong-hai",
                "org": "Department of Electronic Engineering,College of Informational Science and Technology,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronic Engineering,College of Informational Science and Technology,Jinan University,Guangzhou ,China"
            },
            {
                "name": "CHEN Shun-er",
                "org": "Department of Electronic Engineering,College of Informational Science and Technology,Jinan University,Guangzhou ,China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Department of Electronic Engineering,College of Informational Science and Technology,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Computer Engineering and Design",
        "year": 2006
    },
    "Ap1qFbGx": {
        "id": "Ap1qFbGx",
        "title": "Cryptanalysis of image encryption algorithm based on hyper-chaotic system",
        "abstract": "In order to verify the security of an image encryption algorithm based on Logistic chaotic map and Chen hyper-chao-tic system proposed in literature,discussed security analyses of the algorithm and proposed the measures of known plaintext attacks and chosen plaintext attacks for random-sized encrypted images.Besides,pointed out the essential weakness of the algorithm and provided some suggestions to improve its security.",
        "keywords": [
            "cryptanalysis",
            "chaos",
            "hyper-chaos",
            "image encryption"
        ],
        "authors": [
            {
                "name": "LIU Jin-mei",
                "org": "College of Information & Science Technology,Jinan University,Guangzhou ,China;School of Electronic & Information Engi-neering,South China University of Technology,Guangzhou ,China"
            },
            {
                "name": "QIU Shui-sheng",
                "org": "School of Electronic & Information Engi-neering,South China University of Technology,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "College of Information & Science Technology,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Application Research of Computers",
        "year": 2010
    },
    "a8PsM7we": {
        "id": "a8PsM7we",
        "title": "pH sensor based on multi-layer hydrogel coated fiber Bragg grating",
        "abstract": "Aiming at the low sensitivity of the current hydrogel based fiber Bragg grating(FBG) pH sensors,the design of FBG coated with multi-layer hydrogel film is presented. The sensing performance related to the layer thickness is researched. The result shows that a higher sensitivity is achieved by increasing the radius of the gel layer. The sensors with the coating thickness of 580\u03bcm has the optimum response in a pH range of6~9 with the sensitivity of 0.069nm/pH.",
        "keywords": [
            "pH sensor",
            "Hydrogel",
            "fiber Bragg grating"
        ],
        "authors": [
            {
                "name": "LIANG Xiong-chang",
                "org": ""
            },
            {
                "name": "CHEN Shun-er",
                "org": ""
            },
            {
                "name": "HUANG Hong-bin",
                "org": ""
            },
            {
                "name": "LIU Wei-ping",
                "org": ""
            }
        ],
        "venue": "Optical Communication Technology",
        "year": 2013
    },
    "ngEe4E26": {
        "id": "ngEe4E26",
        "title": "Design and implement of interactive voice response platform based on voiceXML",
        "abstract": "A new interactive voice response platform is designed and implemented based on VoiceXML.The platform is used openVXI as voiceXML interpreter and built with a C/S three-layer architecture.By integrating Sanhui voice card,it realized the essential functions of call center,such as speech synthesis,speech recognition and call processing.Using this platform,the telecommunication operators not only can build call center easily,but also provide customers with colorful voice value-added services cooperating with SP/CP.The framework is introduced and the implement of important technologies is discussed in detail.Finally,a test example and its results are given.",
        "keywords": [
            "IVR",
            "openVXI",
            "voiceXML",
            "call center",
            "Sanhui voice card"
        ],
        "authors": [
            {
                "name": "YU Xi-chang",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "WU Jin",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Computer Engineering and Design",
        "year": 2007
    },
    "OT7WBLdc": {
        "id": "OT7WBLdc",
        "title": "Design of access network system based on 10G EPON",
        "abstract": "Improvement and advantages of 10G EPON hierarchical model, which had been standardized in the framework of the IEEE 802.3av Task Force, are analyzed. Based on the analysis, the related upgrading technique scheme of 1G EPON to 10G EPON as well as the corresponding technical key bottlenecks of dynamic bandwidth allocation (DBA) mechanism and security problems are thoroughly studied. Furthermore, three kinds of networking schemes based on 10G EPON systems are proposed, which can respectively be suitable for different situations of FTTH, FTTO and mobile communications. At the same time, these schemes can support various triple-play services and effectively integrate the computer communication with telephone and video services, providing a good reference for future 10G EPON access network system.",
        "keywords": [
            "10g epon",
            "backhaul",
            "ftth",
            "ieee 802.3av",
            "epon",
            "service provider",
            "data mining",
            "hierarchical model",
            "bandwidth",
            "passive optical networks",
            "telephony",
            "mobile communication",
            "dynamic bandwidth allocation",
            "mobile communications",
            "access network",
            "local area networks"
        ],
        "authors": [
            {
                "name": "Xiong Nian",
                "org": "Jinan University(Jinan University),Jinan,China"
            },
            {
                "name": "Xu Baomin",
                "org": "Co., Ltd(Co., Ltd,Telecommunications Co., Ltd.,Guangzhou Telecom Co., Ltd.,Telecom Corporation Ltd.,Telecommunications Co. Ltd.),Guangzhou,China"
            },
            {
                "name": "Zeng Zhiwei",
                "org": "Jinan University(Jinan University),Jinan,China"
            },
            {
                "name": "Chen Shun'er",
                "org": "Jinan University(Jinan University),Jinan,China"
            },
            {
                "name": "Liu Weiping",
                "org": "Jinan University(Jinan University),Jinan,China"
            }
        ],
        "venue": "2009 4th International Conference on Communications and Networking in China, CHINACOM 2009",
        "year": 2009
    },
    "U2lLJ7Uw": {
        "id": "U2lLJ7Uw",
        "title": "The Research of Implementing Absolute QoS Based on Resource Reservation Technology in OBS",
        "abstract": "Some developing technologies of resource reservation and supporting absolute QoS in OBS are introduced,and their technology performances are compared and analyzed. Combining Min-Sv and DWG, a model which can implement absolute QoS is proposed. This model show some advantages,such as promoting bandwidth utilization and improving whole performance of network.",
        "keywords": [
            "OBS absolute QoS resource reservation"
        ],
        "authors": [
            {
                "name": "LIU Waixi",
                "org": "Jinan University~1, Guangzhou ; Information and Electromechanical School, Guangzhou University~4, Guangzhou "
            },
            {
                "name": "LIU Weiping",
                "org": "Jinan University~1, Guangzhou "
            },
            {
                "name": "HUANG Hongbin",
                "org": "Jinan University~1, Guangzhou "
            },
            {
                "name": "YU Xirong",
                "org": " Institute of Telecommunication Programme and Design of Guangdong Province~2, Guangzhou "
            },
            {
                "name": "SU Wenbin",
                "org": " Guangzhou Tianma Motorcycle Limited Company~3, Guangzhou "
            }
        ],
        "venue": "Science Technology and Engineering",
        "year": 2006
    },
    "1J1zlHKS": {
        "id": "1J1zlHKS",
        "title": "Discussion and design of packet capture method in intrusion detecting system",
        "abstract": "Two network packet capture method are discussed,SOCKET_PACKET and BPF.As follows,a very wide-used packet capture library Libpcap is introduced in detail,which supports BPF.Its main functions are explained.Then a useful packet capture pro-gramming frame is designed.Snort,which is an open-sourced network intrusion detecting system,captures network packets by Libpcap.After analyzed and explained in detail based on the Snort source code,the mechanism of capturing packets in Snort also obeys the pro-gramming frame we design.Since packet capture method is also used in many other fields,such as network monitoring system,the programming frame has great values to relative researches and developments.",
        "keywords": [
            "BPF",
            "Libpcap",
            "Snort",
            "NIDS",
            "packet capture"
        ],
        "authors": [
            {
                "name": "PENG Jing",
                "org": "Department of Electronic Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronic Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Department of Electronic Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "XIE Jing",
                "org": "College of Basic Science,Huazhong Agricultural University,Wuhan ,China"
            },
            {
                "name": "LI Xi-ming",
                "org": "Modern Education Center,South China Agriculture University,Guangzhou ,China"
            }
        ],
        "venue": "Computer Engineering and Design",
        "year": 2006
    },
    "AeguAUQH": {
        "id": "AeguAUQH",
        "title": "Designing scheme of 160 system based on ethernet switching technology",
        "abstract": "A designing scheme of 160 system in Ethernet based on FastTran is introduced. FastTran box is a new-designed device, which implements the function of fast signal transferring from PSTN to LAN. A common personal computer is acted as switching server, which can analyze the SS7 signal and coordinate the communication between personal computer and telephone. Based on FastTran, a B/S structure is used in the 160 system. ActiveX control is designed to realize voice communication and is embedded into the ASP, which is the agent page used by seats.",
        "keywords": [
            "Ethernet switch",
            "FastTran",
            "SS7"
        ],
        "authors": [
            {
                "name": "Jing Peng",
                "org": "Jinan University(Jinan University),Jinan,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Jinan University(Jinan University),Jinan,China"
            },
            {
                "name": "Ximing Li",
                "org": "Jinan University(Jinan University),Jinan,China"
            },
            {
                "name": "Hongbin Huang",
                "org": "Jinan University(Jinan University),Jinan,China"
            }
        ],
        "venue": "Jisuanji Gongcheng/Computer Engineering",
        "year": 2005
    },
    "W7JihgN9": {
        "id": "W7JihgN9",
        "title": "The research and application of 10G EPON technology",
        "abstract": "This paper analyzed the improvement of hierarchical model of 10G EPON which was standardized in the framework of the IEEE 802.3av Task Force,and comparatively analyzed technical advantages of 10G EPON.By investigating the system updating process of 1G EPON to 10G EPON as well as the technical bottlenecks emerged,three networking schemes based on 10G EPON systems respectively suitable for different situations of family,commerce and backhaul of mobile base station were proposed.These schemes,which support various advanced network services,provide a good referrence for future 10G EPON access network system.",
        "keywords": [
            "10G EPON",
            "IEEE 802.3av",
            "FTTH",
            "backhaul"
        ],
        "authors": [
            {
                "name": "XIONG Nian",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "CHEN Shun-er",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "RAN Yang",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "ZENG Zhi-wei",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Optical Communication Technology",
        "year": 2008
    },
    "wiEkVBhR": {
        "id": "wiEkVBhR",
        "title": "Optimized design and implementation of NGB billing system",
        "abstract": "EPON-EOC-based access technology is a mainstream proposal for Triple-play of China's Next Generation Broadcasting Network(NGB).This paper makes an in-depth analysis of its network architecture and presents the demand features of the NGB billing system and designs on this basis a technical solution to its optimization.This solution is verified in experiments to be feasible and effective,offering a valuable reference for the further development of NGB Triple-play.",
        "keywords": [
            "billing",
            "optimization",
            "NGB",
            "EOC",
            "EPON"
        ],
        "authors": [
            {
                "name": "Xiong Nian",
                "org": "School of Information Science and Technology,Jinan University,Guangzhou ,China"
            },
            {
                "name": "Liu Weiping",
                "org": "School of Information Science and Technology,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "Song Mengchun",
                "org": "Guangdong Medical Devices Quality Surveillance and Test Institute,Guangzhou ,China"
            }
        ],
        "venue": "Study on Optical Communications",
        "year": 2012
    },
    "DPjiLE9Q": {
        "id": "DPjiLE9Q",
        "title": "The Design of Fiber Transceiver Network Management System Based on Socket and UDP Protocol",
        "abstract": "An idea of design for fiber transceiver system based on Socket and UDP protocol is described in this paper.Some classes of Socket,which are used in our project,and the process of realizing the system are introduced.At Last,the system is debugged with a simulated server.Thus,a valuable reference for fiber transceiver network management system is provided.",
        "keywords": [
            "network management system",
            "SNMP",
            "UDP",
            "Socket",
            "fiber transceiver"
        ],
        "authors": [
            {
                "name": "Zeng Zhiwei",
                "org": "Jinan University,Guangzhou ,Guangdong"
            },
            {
                "name": "Huang Hongbin",
                "org": "Jinan University,Guangzhou ,Guangdong"
            },
            {
                "name": "Chen Shuner",
                "org": "Jinan University,Guangzhou ,Guangdong"
            },
            {
                "name": "Liu Weiping",
                "org": "Jinan University,Guangzhou ,Guangdong"
            }
        ],
        "venue": "Computer & Telecommunication",
        "year": 2008
    },
    "2PtEnVh7": {
        "id": "2PtEnVh7",
        "title": "The design and implementation of configuration management sub-system for EPON",
        "abstract": "Intensively study and analysis the functions and key technologies.The configuration management scheme of EPON system based on the Web and the SNMP protocol was designed and implemented with JAVA language,JSP technology and Oracle 10g database technology,which achieves the functions such as restart the device,storage,query,modify,add and delete the configuration of the information.Finally the configuration management system was tested and analyzed.",
        "keywords": [
            "SNMP",
            "Web",
            "configuration management",
            "EPON"
        ],
        "authors": [
            {
                "name": "XIE Hai-ming",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "XU Hong",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "PAN Zhi-hong",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "NIE Jing",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Optical Communication Technology",
        "year": 2010
    },
    "zL6WdJt2": {
        "id": "zL6WdJt2",
        "title": "Rational Thinking on the Development of PON",
        "abstract": "PON is a new technology emerged in the recent years.It includes APON(ATM PON),EPON(Ethernet PON)and GPON(Gigabit PON).The key techniques and features of these access networks are analyzed and compared in detail.Finally,the problems and suggestions in the development of PON technology are presented.",
        "keywords": [
            "PON",
            "FTTH",
            "access technology"
        ],
        "authors": [
            {
                "name": "YU Xi-chang",
                "org": "Department of Electronics Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronics Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "ZHENG Li-ming",
                "org": "Department of Electronics Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Department of Electronics Engineering,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Optical Fiber & Electric Cable and Their Applications",
        "year": 2006
    },
    "Bqi82lFu": {
        "id": "Bqi82lFu",
        "title": "Design and Implement of Tops Embedded Browser",
        "abstract": "With comprehensively researching in the characteristics and development of embedded browser technology,the design of Tops embedded browser is implemented.The framework is introduced and the implementation of important technologies is discussed in detail.Finally,a test example and its performance report are given.",
        "keywords": [
            "layout algorithm",
            "Tops",
            "parser algorithm",
            "embedded browser",
            "digital TV middleware"
        ],
        "authors": [
            {
                "name": "ZHAN Bao-rong",
                "org": "Department of Electronic and Engineering,Guangzhou University Sontan College,Guangzhou ,China"
            },
            {
                "name": "YU Xi-chang",
                "org": "Guangdong Nortel Communication Co.,Ltd.,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "CHEN Shun-er",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Video Engineering",
        "year": 2008
    },
    "y5zFkK0D": {
        "id": "y5zFkK0D",
        "title": "LED based multiple wavelength photorejuvenating system",
        "abstract": "Operating principles of photorejuvenation are analyzed and the present photorejuvenating systems are also analyzed and compared.A LED based multiple wavelength photorejuvenation system is designed,in which high power LEDs are used and LED arrays consisted of six different wavelengths are construct-ed.The system can be used in different photorejuvenating applications.",
        "keywords": [
            "photo-therapeutic system",
            "photorejuvenation",
            "LED",
            "multi-wavelength"
        ],
        "authors": [
            {
                "name": "LIU Weiping",
                "org": "Deptment of EE,Jinan University,Guangzhou,China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Deptment of EE,Jinan University,Guangzhou,China"
            },
            {
                "name": "DU Wei-chong",
                "org": "Innotek Zhongshan Ltd,Zhongshan,China"
            }
        ],
        "venue": "Laser Journal",
        "year": 2005
    },
    "YEPB1GWY": {
        "id": "YEPB1GWY",
        "title": "Design and Implementation of Auto-dial Testing System Based on Ethernet Communication",
        "abstract": "Aiming at the problems of the current telephone dial testing system such as complicated structure,low compatibility and short controlling distance,etc,a new design of telephone auto-dial testing system through Ethernet communication based on MCU was advanced.The transmission between equipments on Ethernet had been realized by embedded the TCP/IP protocol into the MCU and the system has passed the practical test of Telecom Department.The system,which is portable,cross-platform,low-cost and convenient for upgrade and extension,will provide a good reference in designing of the auto-dial testing system.",
        "keywords": [
            "Ethernet",
            "auto-dial testing",
            "call plan",
            "RTL8019AS",
            "MCU"
        ],
        "authors": [
            {
                "name": "SHEN Chen",
                "org": "Department of Electronics Engineering,Jinan university,Guangzhou,,China"
            },
            {
                "name": "LIU WeiPing",
                "org": "Department of Electronics Engineering,Jinan university,Guangzhou,,China"
            },
            {
                "name": "HUANG HongBin",
                "org": "Department of Electronics Engineering,Jinan university,Guangzhou,,China"
            },
            {
                "name": "CHEN ShunEr",
                "org": "Department of Electronics Engineering,Jinan university,Guangzhou,,China"
            }
        ],
        "venue": "Microcomputer Applications",
        "year": 2008
    },
    "12JYDAJD": {
        "id": "12JYDAJD",
        "title": "Study on Transmission Spectrum of Cascaded Long-period Fiber Gratings",
        "abstract": "An improved method of cascaded long-period fiber gratings(LPFGs) is proposed,which can effectively broaden the resonant spectrum bandwidth of LPFGs.The positioning of the resonance peak of transmission spectra in LPFGs was analyzed.A cascaded LPFG was obtained by cascading various LPFGs with the same period but different length and index perturbation.Transfer matrix method was used to numerically calculate its transmission spectrum,and it is found that the effective bandwidth will become wider and the shapes will correspondingly change if the related parameters in cascaded LPFG,such as the number of segments and length and index perturbations of each segment,are adjusted correctly.",
        "keywords": [
            "resonant wavelength",
            "cascade",
            "LPFG",
            "transmission spectra"
        ],
        "authors": [
            {
                "name": "CUI Chun-lei",
                "org": "Guangdong Communication Polytechnic,Guangzhou ,CHN"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronic Engineering,Jinan University,Guangzhou ,CHN"
            }
        ],
        "venue": "Semiconductor Optoelectronics",
        "year": 2009
    },
    "zNGv5vDP": {
        "id": "zNGv5vDP",
        "title": "A reversible visible watermarking algorithm based on novel modified integer DCT_DWT",
        "abstract": "A Pretreating template based on user-key-dependent watermark pretreatment and the corresponding embedding function,in the novel modified integer DCT_DWT,achieved the embedding of watermark and the recovery of the original image.At the same time,it compared the effect of this novel method in DWT.Experimental results showed,at the modified integer DCT_DWT,it could get higher quality image restoration which has higher PSNR,compared with the original image.",
        "keywords": [
            "reversible visible watermarking",
            "image",
            "pretreating template",
            "modified integer DCT_DWT"
        ],
        "authors": [
            {
                "name": "GAO Jie",
                "org": "Department of Electronic and Engineering,School of Information Science and Technology, Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Weiping",
                "org": "Department of Electronic and Engineering,School of Information Science and Technology, Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Journal of Jinan University(Natural Science & Medicine Edition)",
        "year": 2013
    },
    "PsJnJpM3": {
        "id": "PsJnJpM3",
        "title": "Design and Implementation of Data Collection and Control System Based on Java and Serial Communication",
        "abstract": "This paper introduces one of data collection and control system which is designed and implemented basing on java and serial communication technology with reference to exploite the Greenhouse Intelligent Control System (GICS).The paper gives a elaborate explanation of java and serial communication,multi-thread processing technology,database accessing technology and data Visual expression which relate to the realization.",
        "keywords": [
            "comm.jar",
            "multi-thread",
            "serial communication",
            "database",
            "Java"
        ],
        "authors": [
            {
                "name": "WU Jin-feng",
                "org": ""
            },
            {
                "name": "LIU Wei-ping",
                "org": ""
            },
            {
                "name": "HUANG Hong-bin",
                "org": ""
            }
        ],
        "venue": "Microcomputer Information",
        "year": 2010
    },
    "OI57yClk": {
        "id": "OI57yClk",
        "title": "Design and simulation of laser diode driver with narrow pulse width and high peak circuit",
        "abstract": "Designed a narrow pulse width and high peak current pulse laser diode driver circuit,and the circuits have been analyzed,Multisim simulated.By contrast,the simulation took account the circuit and LD parasitic parameters,making the simulation more consistent with the actual circuit.The circuit structure is simple,circuit of the high speed switching part adopts the special MOSFET hardware acceleration shut off the circuit,as the energy storage,using capacitor charging and discharging way to provide instantaneous narrow pulse and large curront pulse output,pulse width are below 2.5 ns and rise time are below 3.5 ns,peak current more than 20 A.",
        "keywords": [
            "Multisim simulation",
            "high-speed switch",
            "narrow pulse width and high peak current",
            "parasitic parameter",
            "capacitor charge and discharge",
            "laser diode driver"
        ],
        "authors": [
            {
                "name": "XIE Jun-hua",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "CHEN Shun-er",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Laser Journal",
        "year": 2012
    },
    "whkfdmBR": {
        "id": "whkfdmBR",
        "title": "High stability digital temperature control for laser source",
        "abstract": "Based on the measured response curve of semiconductor cooler module,its mathematical model is obtained by the method of curve fitting,With the parameters of the model being used,we design a PID controller which can compensate the phase delay of cooler module effectually to control the LD's temperature.Experiment results demonstrate that the controller can keep LD module in preset temperature with high stability of \u00b10.05\u2103.",
        "keywords": [
            "Temperature control: Semiconductor cooler",
            "Laser diode"
        ],
        "authors": [
            {
                "name": "LIN Shi-xiang",
                "org": "Electronic Engineering Department of Informational Science and Technology College,Guangzhou Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Electronic Engineering Department of Informational Science and Technology College,Guangzhou Jinan University,Guangzhou ,China"
            },
            {
                "name": "CHEN Shun-er",
                "org": "Electronic Engineering Department of Informational Science and Technology College,Guangzhou Jinan University,Guangzhou ,China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Electronic Engineering Department of Informational Science and Technology College,Guangzhou Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Min",
                "org": "Electronic Engineering Department of Informational Science and Technology College,Guangzhou Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Laser Journal",
        "year": 2006
    },
    "bZkYK0zb": {
        "id": "bZkYK0zb",
        "title": "EDFA gain-flattening based on the cascade of step-changed LPGs",
        "abstract": "By analyzed the two-step cascaded step-changed LPGs which have been already used as band filters for flattening the gain of erbium-doped fiber amplifiers(EDFAs),an improved method of introducing three or more steps cascade has been advanced in order to optimize the transmission spectra of the filters.The calculation and simulation,based on coupled-mode theory,of the cascaded LPGs' transmission spectra are given.The simulation results show that the transmission spectral profile can be tailored into an adoptive shape and simultaneously the effective bandwidth would become wider by adjusting the two parameters,the length and the index perturbations of each segment in cascade.This method proposed in the paper is demonstrated to be an effective way to flatten the gains profile of EDFAs.A theoretical basis is provided for optimizing the application of EDFAs in optical communication and WDM fiber-sensor network system.",
        "keywords": [
            "band filter",
            "cascade",
            "coupled-mode theory",
            "gain-flattening",
            "step-changed lpgs",
            "optical fibers",
            "optical amplifier"
        ],
        "authors": [
            {
                "name": "Yang Ran",
                "org": "Jinan University(Jinan University),Jinan,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Jinan University(Jinan University),Jinan,China"
            },
            {
                "name": "Weichong Du",
                "org": "Jinan University(Jinan University),Jinan,China"
            },
            {
                "name": "Hongbin Huang",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "shuner chen",
                "org": "Jinan University(Jinan University),Jinan,China"
            }
        ],
        "venue": "Proceedings of SPIE - The International Society for Optical Engineering",
        "year": 2008
    },
    "Z4pSXoGI": {
        "id": "Z4pSXoGI",
        "title": "Design and Implementation of EoC Configuration Management System",
        "abstract": "The device configuration management scheme of EoC system based on the model of B/S and the framework of MVC was designed,and which is implemented from systems Longitudinal function,which completes the functions such as display,configuration and saving of modules information.Finally,the function of system was tested and analyzed.",
        "keywords": [
            "SNMP",
            "EoC",
            "MVC",
            "B/S"
        ],
        "authors": [
            {
                "name": "XU Hong",
                "org": ""
            },
            {
                "name": "NIE Jing",
                "org": ""
            },
            {
                "name": "XIE Haiming",
                "org": ""
            },
            {
                "name": "PAN Zhihong",
                "org": ""
            },
            {
                "name": "LIU Weiping",
                "org": ""
            }
        ],
        "venue": "Video Engineering",
        "year": 2011
    },
    "1aaej3dY": {
        "id": "1aaej3dY",
        "title": "Design of Temperature Sensing System Based on Apodizing FBG Array",
        "abstract": "By means of two-exposure apodizing process which had been further researched,the FBG with high reflectivity and high sdelobe suppression rate was fabricated.And then,based on the apodizing FBG,a new design of the monitoring temperature sensing array system was advanced using virtual instrument.In the system,the capacity could be enlarged and also the problem of sensing channel crosstalk caused by FBG sidelobe was able to be eliminated.Thus,the design proposed was demostrated to be an effective way in multi-point real-time temperature monitoring cases,such as electric power and petroleum systems.The research provided a good referrence in realizing the high capacity temperature&strain sensing system and DWDM system.",
        "keywords": [
            "apodizing",
            "FBG",
            "temperature sensing system"
        ],
        "authors": [
            {
                "name": "RAN Yang",
                "org": "Jinan University,Guangzhou ,China"
            },
            {
                "name": "ZENG Zhi-wei",
                "org": "Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Instrument Technique and Sensor",
        "year": 2009
    },
    "Cnig6yEt": {
        "id": "Cnig6yEt",
        "title": "The Design and Implementation of Wireless Educational Administration Management System Based on WAP",
        "abstract": "Intensively study and analysis the function of original educational administration management system and key technologies of WAP.The scheme of wireless educational administration management system based on the WAP protocol was designed and implemented with wireless markup language(WML),ASP technology and Microsoft SQL Server 2008 database technology,which achieves the function such as query the information through mobile,modify the telephone number,verifies the authenticity of the certificate.Finally the wireless educational administration management system was tested and analyzed.",
        "keywords": [
            "WML",
            "WAP",
            "wireless educational administration"
        ],
        "authors": [
            {
                "name": "ZHONG Xiang-rui",
                "org": "Department of Computer Information,Guangdong Polytechnic College,Guangzhou ,China"
            },
            {
                "name": "XIE Hai-ming",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Computer Knowledge and Technology",
        "year": 2012
    },
    "eCEImt6n": {
        "id": "eCEImt6n",
        "title": "The Control System for Optical Power Meter Based on Lab VIEW",
        "abstract": "To design and develop the control platform for the Optical Power Meter on the PC end, through the VISA-serial in the Lab VIEW, this Optical Power Meter could manage the serial communication on the PC end, and can realize long distance control, long time automatic measurement, and data analysis and conservation. The result of the test demonstrates this system can circulate precisely and is reliable. It has well practicability and worth to generalize.",
        "keywords": [
            "LabVIEW virtual instrument optical power meter micro control unit serial"
        ],
        "authors": [
            {
                "name": "QI Pan",
                "org": "Department of Electronics Engineering, Jinan University, Guangzhou "
            },
            {
                "name": "LIU Weiping",
                "org": "Department of Electronics Engineering, Jinan University, Guangzhou "
            },
            {
                "name": "HUANG Hongbin",
                "org": "Department of Electronics Engineering, Jinan University, Guangzhou "
            }
        ],
        "venue": "Science Technology and Engineering",
        "year": 2006
    },
    "8RQbqs5Q": {
        "id": "8RQbqs5Q",
        "title": "Research and Application of PCF Grating",
        "abstract": "Photonic crystal fiber(PCF) grating is a new type of fiber grating with advanced properties which standard fiber grating do not have.Not only the fabrication methods for PCF grating are introduced and analyzed,but also the properties of PCF Bragg grating and PCF long period grating are illustrated.Finally the application prospect of them are discussed.",
        "keywords": [
            "photonic crystal fiber",
            "photonic crystal fiber grating",
            "fiber grating"
        ],
        "authors": [
            {
                "name": "ZENG Zhi-wei",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "CHEN Shun-er",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Optical Fiber & Electric Cable and Their Applications",
        "year": 2008
    },
    "aqdJ3WTN": {
        "id": "aqdJ3WTN",
        "title": "Simulation Analysis of LD Pulse Drive Circuit Based on HSPICE",
        "abstract": "High-speed pulse driven circuit was simulated by the HSPICE software and the effects of the parasitic parameters of the circuit can be clearly learned through simulation,and it supplies a reference for the latter job about making the circuit board.It is different from approximate simulation,in order to reflect the characteristic of the LD accurately,a big signal SPICE model of semiconductor laser is built,and then schematic diagram of the high-speed MOSFET switch circuit is designed.After analyzing and determining the parameters,the circuit is simulated and the simulation result is consistent with the actual circuit.",
        "keywords": [
            "HSPICE pulse driven simulate LD"
        ],
        "authors": [
            {
                "name": "CHEN Wei-liang",
                "org": "Department of Electronics Engineering,Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,P.R.China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronics Engineering,Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,P.R.China"
            },
            {
                "name": "CUI Zhong-yi",
                "org": "Department of Electronics Engineering,Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,P.R.China"
            },
            {
                "name": "CHEN Xin",
                "org": "Department of Electronics Engineering,Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,P.R.China"
            }
        ],
        "venue": "Science Technology and Engineering",
        "year": 2010
    },
    "ZWxXbwiu": {
        "id": "ZWxXbwiu",
        "title": "Optical Cross-Connect Devices in ASON",
        "abstract": "Optical cross-connect(OXC) is one of the key technologies for optical nodes,and OXC devices are the core part of an automatic switched transport network(ASON).Firstly,the basic concept and advantages of ASON are described.The construction and working principle of OXC are presented.The key technologies for realizing intellegent OXC devices are discussed.The two supplemental technologies which are used for intelligent OXC in ASON,intelligent optical MEMS and generalized multi-protocol label switching,are presented.",
        "keywords": [
            "ASON",
            "GMPLS",
            "OXC",
            "intelligent optical MEMS"
        ],
        "authors": [
            {
                "name": "XIE Jing",
                "org": "Department of Electrical Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electrical Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "KANG Ying",
                "org": "Department of Electrical Engineering,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Optical Fiber & Electric Cable and Their Applications",
        "year": 2006
    },
    "kaGLMbhU": {
        "id": "kaGLMbhU",
        "title": "Trends of WDM-PON and Multi-Wavelength Source",
        "abstract": "The architecture and technical advantages of WDM-PON system is presented.Then the key device,multi-wavelength optical source,is analyzed.Finally the application prospect of WDM-PON in broadband access network is discussed.",
        "keywords": [
            "multi-wavelength source",
            "WDM-PON",
            "AWG"
        ],
        "authors": [
            {
                "name": "JIANG Yu",
                "org": "Department of Electronics Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronics Engineering,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Optical Fiber & Electric Cable and Their Applications",
        "year": 2008
    },
    "k7Xd5syo": {
        "id": "k7Xd5syo",
        "title": "Study of programmable IVR system based on packet-transfer technology",
        "abstract": "IVR(interactive voice response) system is one kind of telecom added value service system.A new programmable IVR architecture is proposed,in which process tree is combined with database,and the packet-transfer technology,which transfers E1 frame in PSTN to MAC frame in LAN quickly by packet-transfer device,is adopted.The IVR flow is stored in database,in the form of table,which is browsed and edited easily with IVR flow editor.",
        "keywords": [
            "process tree",
            "interactive",
            "programmable flow",
            "flow editor",
            "voice response",
            "packet-transfer"
        ],
        "authors": [
            {
                "name": "LI Hong",
                "org": "Guangdong Polytechnic College,Guangzhou ,China"
            },
            {
                "name": "PENG Jing",
                "org": "Department of Electronic Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Department of Electronic Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronic Engineering,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Computer Engineering and Design",
        "year": 2008
    },
    "W0Zen1eu": {
        "id": "W0Zen1eu",
        "title": "Research on Performance of FBG Sidelobes Supression Based on Double-exposure Apodizing Technology",
        "abstract": "The method of obtaining refractive index of DC component by double exposure was introduced for apodizing the reflection specta of fiber bragg gratings(FBG).The double-exposure apodizing FBGs,compared with single exposure ones based on different apodize beam respectively,had been demonstrated having better effects on the suppression performance of sidelobe and bandwidth in the reflection spectra.A theoretical basis and good referrences were provided to the process of double-exprourse apodizing FBGs used in dense wavelength division multiplexing system.",
        "keywords": [
            "double-exposure apodizing",
            "FBG",
            "sidelobe suppression"
        ],
        "authors": [
            {
                "name": "WU Xia",
                "org": "Electronic Engneering Department,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong HigherEducational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "RAN Yang",
                "org": "Electronic Engneering Department,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong HigherEducational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Electronic Engneering Department,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong HigherEducational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "XIONG Song-song",
                "org": "Electronic Engneering Department,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong HigherEducational Institutes,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Instrument Technique and Sensor",
        "year": 2010
    },
    "4bVXVLJd": {
        "id": "4bVXVLJd",
        "title": "Design and implementation of EPON optical power meter system",
        "abstract": "Through analysis of EPON technology and its transmission signal system,this paper discusses the optical and circuit schemes.Uplink and downlink signals take different hardware circuit structure.The system design application specific electrical circuit to capture uplink burst-mode pulse signal.The problem how to measure uplink burst-mode optical signal power accurately has been solved from hardware circuit.On-line measurement EPON optical power meter was successfully invented in the end.",
        "keywords": [
            "on line measurement",
            "EPON optical power meter",
            "application specific electrical circuit",
            "burst-mode capture"
        ],
        "authors": [
            {
                "name": "HE Cheng-qiang",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "CHEN Shun-er",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "PENG Yu",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "XIE Jun-hua",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Optical Communication Technology",
        "year": 2012
    },
    "TjKuUL4r": {
        "id": "TjKuUL4r",
        "title": "The design and implementation of online contribution and review system",
        "abstract": "Intensively study and analyze the function and key technoligoes.The online contribution and review system based on the structure of B/S was designed and implemented with the MVC model of Struts2 +Spring +Jpa,the technology of Java,JSP and Mysql.Finally,the system was tested and analyzed.",
        "keywords": [
            "MySQL",
            "Struts2+Spring+Jpa",
            "MVC",
            "contribution",
            "review"
        ],
        "authors": [
            {
                "name": "Xu Jing",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optical Fiber Communication and Sensing Technology,Jinan University,Guangzhou ,China"
            },
            {
                "name": "Cheng Dan",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optical Fiber Communication and Sensing Technology,Jinan University,Guangzhou ,China"
            },
            {
                "name": "Zhang Xiaodan",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optical Fiber Communication and Sensing Technology,Jinan University,Guangzhou ,China"
            },
            {
                "name": "Liu Weiping",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optical Fiber Communication and Sensing Technology,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Microcomputer & Its Applications",
        "year": 2011
    },
    "gzGlhjgW": {
        "id": "gzGlhjgW",
        "title": "Simulation Platform\u2019s Realization of System Node about CAN Bus Based on SJA1000",
        "abstract": "This article introduces the simulation platform of system node about CAN bus (Controller Area Network) which was realized with SJA1000 chip. There are many characteristics around this simulation platform, such as applicable, simple, credible, high rate of quality to price and very nice expansibility. It is convenient for the applications in automobiles and other fields.",
        "keywords": [
            "Simulation Platform",
            "CAN Bus",
            "Automation System",
            "SJA1000"
        ],
        "authors": [
            {
                "name": "Li Chuanyi",
                "org": "Department of EE, Jinan University"
            },
            {
                "name": "Chen Shuner",
                "org": "Department of EE, Jinan University"
            },
            {
                "name": "Huang Hongbin",
                "org": "Department of EE, Jinan University"
            },
            {
                "name": "Liu Min",
                "org": "Department of EE, Jinan University"
            },
            {
                "name": "Liu Weiping",
                "org": "Department of EE, Jinan University"
            }
        ],
        "venue": "Guangdong Automation & Information Engineering",
        "year": 2005
    },
    "AXCLoJnW": {
        "id": "AXCLoJnW",
        "title": "Design and Implement of WAP Application System for Location Based Services Based on J2EE",
        "abstract": "Under the prosperous development tendency of mobile value-added service and the extended application of WAP,an application system about location services based on WAP is designed and implemented in this paper.The system adopts J2EE as development platform,and MVC as design module.It implements the basic function module of location service application,and makes the user could obtain the location information by the mobile anytime and anywhere.At the same time the Chinese character encoding,the security of user password,and the access to heterogonous platform are also resolved successfully.",
        "keywords": [
            "location based services system",
            "WAP",
            "MVC",
            "JSP",
            "J2EE"
        ],
        "authors": [
            {
                "name": "ZHAN Bao-rong",
                "org": "Department of Electronic and Engineering,Guangzhou University Sontan College,Guangzhou ,China"
            },
            {
                "name": "YU Xi-chang",
                "org": "GuangDong Nortel communication equipment co.,Ltd,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "CHEN Shun-er",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Wireless Communication Technology",
        "year": 2008
    },
    "iJ07L0yy": {
        "id": "iJ07L0yy",
        "title": "Design and implementation of multi-layer display for EPON_EoC network topology",
        "abstract": "EPON_EOC has become the mainstream proposal in bidirectional transformation for Triple-play,it's necessary to equip it with a unified network management system(NMS).And one of the basic requirements of NMS is that displays the network topology by graphical.Based on the realized unified management scheme and topology discovery of EPON_EoC,the design and implementation of multi-layer display for EPON_EoC are achieved by Twaver SVG,as soon as topological editing,topological deriving and so on.By the interaction with alarm management,the alarms on device port and alarm transmission are implemented in topology,too.",
        "keywords": [
            "alarm",
            "EPON_EoC",
            "multi-layer display",
            "networks topology",
            "TWaver SVG"
        ],
        "authors": [
            {
                "name": "CHENG Dan",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "ZHANG Xiao-dan",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "XU Jing",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "PAN Zhi-hong",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Educational Institutes,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Optical Communication Technology",
        "year": 2011
    },
    "oYGp7KRj": {
        "id": "oYGp7KRj",
        "title": "Design and implementation of topology discovery in EPON_EOC unified management systems",
        "abstract": "Most of the EPON and EOC equipment are currently managed by relatively independent Network Management Systems(NMS).On the basis of studies on their network structure and features,this paper proposes an innovative unified management scheme for the unified management of their equipment and designs and implements the topology discovery functions of EPON_EOC equipment.The test results show that this scheme enables the automatic discovery of the EPON-EOC topologic structure to be well implemented.",
        "keywords": [
            "unified network management system",
            "network topology",
            "EOC",
            "EPON"
        ],
        "authors": [
            {
                "name": "Pan Zhihong",
                "org": "Department of Electronic Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "Xie Haiming",
                "org": "Department of Electronic Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "Nie Jing",
                "org": "Department of Electronic Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "Xu Hong",
                "org": "Department of Electronic Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "Liu Weiping",
                "org": "Department of Electronic Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes,Jinan University,Guangzhou ,China"
            },
            {
                "name": "Huang Hongbin",
                "org": "Department of Electronic Engineering,Jinan University,Guangzhou ,China;Key Laboratory of Optoelectronic Information and Sensing Technologies of Guangdong Higher Education Institutes,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Study on Optical Communications",
        "year": 2011
    },
    "4OKbQ2oo": {
        "id": "4OKbQ2oo",
        "title": "Design and application of telecom auto-trunk testing system",
        "abstract": "Currently,auto-trunk testing system is rarely used in telecommunication field.Since there are some problems in telecom ope-ration,a design of telecom auto-trunk testing system is realized.Then the hardware and the software of the system are introduced in detail,the implementing technology of the communication between software and hardware based on socket and UDP is also analyzed,and the characteristic of the system is introduced.Through combining with an example,a new method that adopting telecom auto-trunk testing system in PSTN intelligent project is brought forward.So a reference for the development of telecommunication field and auto-trunk testing system is provided.",
        "keywords": [
            "network management software",
            "UDP",
            "PSTN intelligent project",
            "DTMF",
            "auto-trunk testing"
        ],
        "authors": [
            {
                "name": "HANG Xing",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "CHEN Shun-er",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "CHEN Dong-ming",
                "org": "Guangdong Telecom Panyu Branch,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronic and Engineering,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Computer Engineering and Design",
        "year": 2008
    },
    "SCdCAyXa": {
        "id": "SCdCAyXa",
        "title": "Design and Implementation of the General Interface Converter with FPGA Based on the On-board Diagnostics",
        "abstract": "In this paper,we set the two code schemes of SAE J1850,which are OBDII signal standard in common use,as the research object to design a format converter between the signal of PWM and that of RS 232.It provides a communication interface between the OBDII system and the computer,so that the computer can monitor the state and the parameter of the car.It could work as an OBDII scan tool of powerful function and low cost,if proper software is taken too.",
        "keywords": [
            "format converter",
            "RS 232",
            "SAE J1850",
            "OBDII",
            "FPGA"
        ],
        "authors": [
            {
                "name": "YU Xichang",
                "org": "Information Science and Technology College,Jinan University,Guangzhou,,China"
            },
            {
                "name": "HUANG Hongbin",
                "org": "Information Science and Technology College,Jinan University,Guangzhou,,China"
            },
            {
                "name": "LIU Weiping",
                "org": "Information Science and Technology College,Jinan University,Guangzhou,,China"
            }
        ],
        "venue": "Modern Electronics Technique",
        "year": 2006
    },
    "BSWxyLGs": {
        "id": "BSWxyLGs",
        "title": "Technology Analysis and Application of RoF",
        "abstract": "Some RoF key technologies' solutions are introduced and analyzed,including single sideband optical modulation based on narrow band fiber Bragg grating,adaptive digital predistortion system,and wavelength interleaving based on multiplexing techniques.And the application and trends of RoF technology,such as in 4G wireless access system,road vehicle communication,and indoor coverage of signal system,are introduced.",
        "keywords": [
            "adaptive predistortion",
            "indoor coverage of signal",
            "RVC",
            "RoF",
            "WI",
            "SSBM",
            "4G wireless access"
        ],
        "authors": [
            {
                "name": "HUANG Jia-ming",
                "org": "Department of Electronics Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "CHEN Shun-er",
                "org": "Department of Electronics Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronics Engineering,Jinan University,Guangzhou ,China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Department of Electronics Engineering,Jinan University,Guangzhou ,China"
            }
        ],
        "venue": "Optical Fiber & Electric Cable and Their Applications",
        "year": 2007
    },
    "LLQQOb0K": {
        "id": "LLQQOb0K",
        "title": "Design of Master-Slave Video Surveillance System Based on Embedded Linux",
        "abstract": "Based on analysis and referrence to the developing actuality of Embedded system as well as network video monitoring technic,a scheme of master-slave network video monitoring system is proposed. Built by entire embedded devices in the system,the master module that is embedded video service module and the slave module which represents scene monitoring system communicate with each other through Ethernet. After testing and verification,the proposed system,which has advantages of high reliability,small volume and low cost,accords with the developing direction of video monitoring system.",
        "keywords": [
            "video transmission system",
            "Embedded Linux",
            "Vedio Surveillance"
        ],
        "authors": [
            {
                "name": "ZHANG Duo-ying",
                "org": "Department of Electronics Engineering,Jinan university,Guangzhou ,China"
            },
            {
                "name": "SHEN Chen",
                "org": "Department of Electronics Engineering,Jinan university,Guangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Electronics Engineering,Jinan university,Guangzhou ,China"
            },
            {
                "name": "CHEN Shun-er",
                "org": "Department of Electronics Engineering,Jinan university,Guangzhou ,China"
            }
        ],
        "venue": "Microcomputer Information",
        "year": 2010
    },
    "A6sgRzzc": {
        "id": "A6sgRzzc",
        "title": "Design and Implement of Embedded Automatic Call Testing System",
        "abstract": "Automatic Call Testing System can improve work efficiency significantly.The existed products in the market have lots of parts,also complicated and expensive.A simple and low cost embedded system uses WINBONDW78E58B as controller.It works with telecommunication module to realizes signal sending and receiving of Automatically Dialing and Testing Terminal as well as phone information detecting function.Through net module,it realizes to communication between Client End and Server End.The design has passed telephone system testing by China Telecom Group.In the fixed telephone net of China Telecom Group,the design has passed testing successfully to automatic call for both the fixed telephone net of China Telecom Group and the mobile phone net of China Mobile Communications Corporation,the results of the testing is true and exact to reflect the actual status of net.",
        "keywords": [
            "embedded system automatic call test phone design"
        ],
        "authors": [
            {
                "name": "LIU Shun-cheng",
                "org": "Information Science and Technology College,Jinan University,Guangzhou ,P.R.China"
            },
            {
                "name": "HUANG Jin-fu",
                "org": "Information Science and Technology College,Jinan University,Guangzhou ,P.R.China"
            },
            {
                "name": "HUANG Hong-bin",
                "org": "Information Science and Technology College,Jinan University,Guangzhou ,P.R.China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Information Science and Technology College,Jinan University,Guangzhou ,P.R.China"
            }
        ],
        "venue": "Science Technology and Engineering",
        "year": 2008
    },
    "FNp9r0WW": {
        "id": "FNp9r0WW",
        "title": "Distribution of matrine nanoparticles and its pharmacokinetics in mice",
        "abstract": "Objective To establish an HPLC method for the determination of matrine in mice tissues,and to study tissue distribution of matrine nanoparticles.Methods The test drug was extracted from the plasma and tissue samples by ether.A HROM-Si02 column was used.The mobile phase consisted of methanol\u2014triethylamine(3 uL triethylamine in every 100 mL methano1).Matrine in tissue at different time was determined and the target character was studied.Results The linear calibration curves were 0.1- 5.0 ug.mL-1 and 0.1-10.0ug\u00b7g-1 in the plasma sample and tissue sample respectively.The intra-and inter-day precisions were lower than 10%.Prepared with matrine solution.matrine nanoparticles were extensively distributed in the liver.Target efficiency of matrine nanoparticles and matrine solution in the liver was 42.78 and 21.55 respectively,Ce in the liver was 2.19,and re was 6.31Conclusion This method is fast,sensitive and accurate.Matrine nanoparticles extensively distributed in the liver.",
        "keywords": [
            "nanoparticle",
            "matrine",
            "pharmacokinetics",
            "tissue distribution"
        ],
        "authors": [
            {
                "name": "Li Yanhui",
                "org": ""
            },
            {
                "name": "Li Yuan",
                "org": ""
            },
            {
                "name": "Bao Meihua",
                "org": ""
            },
            {
                "name": "Liu Weiping",
                "org": ""
            }
        ],
        "venue": "Journal of Changsha Medical University",
        "year": 2013
    },
    "Bbk5iXlr": {
        "id": "Bbk5iXlr",
        "title": "Distribution of matrine nanoparticles and its pharmacokinetics in mice",
        "abstract": "Objective To establish an HPLC method for the determination of matrine in mice tissues,and to study tis-sue distribution of matrine nanoparticles.Methods The test drug was extracted from the plasma and tissue samples by ether.AICHROM-SiO2column was used.The mobile phase consisted of methanol-triethylamine(3\u03bcL triethylamine in every 100mL methanol).Matrine in tissue at different time was determined and the target character was studied.Results The linear calibration curves were 0.1-5.0\u03bcg.mL-1 and 0.1-10.0\u03bcg.g-1 in the plasma sample and tis-sue sample respectively.The intra-and inter-day precisions were lower than 10%.Prepared with matrine solution,matrine nanoparticles were extensively distributed in the liver.Target efficiency of matrine nanoparticles and matrine solution in the liver was 42.78and 21.55respectively,Ce in the liver was 2.19,and re was 6.31.Conclusion This method is fast,sensitive and accurate.Matrine nanoparticles extensively distributed in the liver.",
        "keywords": [
            "nanoparticle",
            "matrine",
            "pharmacokinetics",
            "tissue distribution"
        ],
        "authors": [
            {
                "name": "LI Yan-hui",
                "org": "Department of Pharmaceutics,Changsha Medical College,Changsha"
            },
            {
                "name": "LI Yuan",
                "org": "Department of Pharmaceutics,Changsha Medical College,Changsha"
            },
            {
                "name": "BAO Mei-hua",
                "org": "Department of Pharmaceutics,Changsha Medical College,Changsha"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Department of Pharmaceutics,Changsha Medical College,Changsha"
            }
        ],
        "venue": "Central South Pharmacy",
        "year": 2010
    },
    "lqEOEJ6P": {
        "id": "lqEOEJ6P",
        "title": "Atherosclerosis and the effects of flavonoids",
        "abstract": "The present paper overviewed the theories about the formation of atherosclerosis, discussed the effects of endothelial cells as well as lectin-like oxidized low-density lipoprotein receptor-1 on the progress of AS.It also overviewed the researches focusing on the flavonoids on the treatment of AS,and provided some opinions on the development of new medicines for treatment of AS.",
        "keywords": [
            "endothelial cells",
            "Atherosclerosis",
            "low-density lipoprotein",
            "flavonoids"
        ],
        "authors": [
            {
                "name": "Bao Mei-hua",
                "org": " Department of Pharmacy,Changsha Medical University,Changsha,Hunan,China "
            },
            {
                "name": "Liu Wei-ping",
                "org": " Department of Pharmacy,Changsha Medical University,Changsha,Hunan,China "
            },
            {
                "name": "Zhou Chang",
                "org": " Department of Pharmacy,Changsha Medical University,Changsha,Hunan,China "
            }
        ],
        "venue": "Journal of Changsha Medical College",
        "year": 2008
    },
    "sjng2vfu": {
        "id": "sjng2vfu",
        "title": "Study on the Method to Determine the Dissolution of gemifloxacin Pivoxil Dispersible Granules",
        "abstract": "Objective:To establish a method determine the dissolution of gemifloxacin Pivoxil Dispersible Granules.Methods:Distilled water with hydrochloric acid solution (9\u21921000) was used as dissolution medium,and rotational speed was 50 r\u00b7min-1.A UV method was used. The detection wavelength was at 263nm. Results:The linear ranges were between 2\uff5e20\u03bcg\u00b7mg-1 for gemifloxacin Pivoxil Dispersible (r =0 9999).The dissolution at 20min was above 90%. Conclution:The method is accurate and convenient,and can be used for detection of dissolution of the gemifloxacin Pivoxil Dispersible Granules.",
        "keywords": [
            "gemifloxacin",
            "method determine",
            "Dissolution",
            "Pivoxil Dispersible Granules"
        ],
        "authors": [
            {
                "name": "Li shang",
                "org": " The Eighth Hospital of Changsha "
            },
            {
                "name": "Liu weiping",
                "org": " ChangSha Medical College "
            }
        ],
        "venue": "Journal of Changsha Medical College",
        "year": 2008
    },
    "8Dl7xERc": {
        "id": "8Dl7xERc",
        "title": "Protective effects of flavonoids against ischemia/reperfusion injury in rats and the research between structure and effect",
        "abstract": "Object To investigate the effects of flavonoids on ischemia/reperfusion in rats.Methods The injured model was established by ischemia 10 min and reperfused 30 min in rats by LAD-occlusion. The malondialdehyde(MDA),superoxide dismutaes(SOD)of serum and GSH-Px of myocardial homogenate were measured.Results The results showed that flavonoids significantly lowered the content of MDA in serum and increase the activity of SOD and GSH-Px.Conclusion Flavonoids have the effects against ischemia/reperfusion injury in rats,which has the relationship between structure and effect.",
        "keywords": [
            "ischemia/reperfusion",
            "MDA",
            "SOD",
            "GSH-Px",
            "flavonoids"
        ],
        "authors": [
            {
                "name": "Zhou Chang",
                "org": " Changsha Medical College,Changsha ,Hunan,China"
            },
            {
                "name": "Bao Meihua",
                "org": " Changsha Medical College,Changsha ,Hunan,China"
            },
            {
                "name": "Liu Weiping",
                "org": " Changsha Medical College,Changsha ,Hunan,China"
            }
        ],
        "venue": "Journal of Changsha Medical College",
        "year": 2008
    },
    "fznhuaEe": {
        "id": "fznhuaEe",
        "title": "Effects of biatractylolide on the AD rats induced by AlCl3",
        "abstract": "Objective To investigate the effects of biatractylolide on AD rats induced by AlCl3.Methods The mice's ability of memorizing was studied by the water maze method.After the death of the mice,we took off the brain,and measured the AchE content through the method of colorimetry.Results Biatractylolide could improve the memory function of the AD rats induced by AlCl3,and reduce the AchE activity in the brain.Conclusion Biatractylolide could improve the studying memory of the AD rats induced by AlCl3 and reduce AchE activity.",
        "keywords": [
            "mice",
            "biatractylolide",
            "study",
            "memory"
        ],
        "authors": [
            {
                "name": "Zhou Chang",
                "org": "Changsha MedicaL College,Changsha ,China"
            },
            {
                "name": "Bao Mei-hua",
                "org": "Changsha MedicaL College,Changsha ,China"
            },
            {
                "name": "Liu Wei-ping",
                "org": "Changsha MedicaL College,Changsha ,China"
            }
        ],
        "venue": "Journal of Changsha Medical College",
        "year": 2008
    },
    "tqyBgZKl": {
        "id": "tqyBgZKl",
        "title": "Application of inquiry learning in pharmaceutical botany teaching",
        "abstract": "Objective To promote teaching qualities of pharmaceutical botany and study the effect of new method on pharmaceutical botany teaching.Methods 54 students were chosen in grade 2010 pharmaceutic preparation class and divided into two groups,namely the inquiry learning teaching method group and the traditional teaching method group,then each group was taught with the corresponding teaching method.At the end of the course,a unified exam was taken,the scores were used to assess the teaching quality,partcipating in the research projects,publishing papers and participating in competition were used to quantize research capacity,besides,a questionnaire was employed to evaluate students' learning attitude and their learning motivation.Results The inquiry learning teaching method group were significantly better than the traditional teaching method group in the apects of test scores,research capacity,learning attitude and academic motivation,the differences were statistically significant(P < 0.05).Conclusion Inquiry learning is worthy of further research and promotion in pharmaceutical botang teaching.",
        "keywords": [
            "Pharmaceutical botany",
            "Medicinal botanical garden",
            "Inquiry learning"
        ],
        "authors": [
            {
                "name": "XIAO Haiying",
                "org": " Department of Pharmaceutical,Changsha Medical University,Hu'nan Province,Changsha ,China"
            },
            {
                "name": "BAO Meihua",
                "org": " Department of Pharmaceutical,Changsha Medical University,Hu'nan Province,Changsha ,China"
            },
            {
                "name": "WANG Jianfen",
                "org": " Department of Pharmaceutical,Changsha Medical University,Hu'nan Province,Changsha ,China"
            },
            {
                "name": "LIU Weiping",
                "org": " Department of Pharmaceutical,Changsha Medical University,Hu'nan Province,Changsha ,China"
            },
            {
                "name": "XIAO Yan",
                "org": " Department of Pharmaceutical,Changsha Medical University,Hu'nan Province,Changsha ,China"
            }
        ],
        "venue": "China Medical Herald",
        "year": 2012
    },
    "RB4clBV4": {
        "id": "RB4clBV4",
        "title": "The research of the increasing effects on the number of leukocyte by marine life polysaccharide FW-1",
        "abstract": "Objective To investigate the effects of marine life polysaccharide FW-1 on increasing leukocyte.Methods The leukocytopenia model was induced by cyclophosphamide(CTX).The model was used to study the quantity of leukocyte in the blood,the quantity of peripheral leukocytes in the bone,the weight index of splenic organ and thymus.Results FW-1 could obviously increase the quantity of peripheral leukocytes of mice induced by CTX,so did the quantity of bone marrow cells and the weight of splenic organ and thymus.Conclusion FW-1 has obviously protective function on the chemotherapy mice.",
        "keywords": [
            "marine life polysaccharide FW-1",
            "peripheral leukocytes",
            "cyclophosphamide",
            "immune organ",
            "bone marrow cells"
        ],
        "authors": [
            {
                "name": "Bao Mei-hua",
                "org": "Changsha MedicaL College,Changsha ,China"
            },
            {
                "name": "Zhou Chang",
                "org": "Changsha MedicaL College,Changsha ,China"
            },
            {
                "name": "Liu Wei-ping",
                "org": "Changsha MedicaL College,Changsha ,China"
            }
        ],
        "venue": "Journal of Changsha Medical College",
        "year": 2008
    },
    "FQUXCEAh": {
        "id": "FQUXCEAh",
        "title": "Corrigendum to \u201cCongener-specific composition of polychlorinated biphenyls (PCBs) in soil-air partitioning and the associated health risk\u201d [Sci. Total Environ. 684(2019) 486\u2013495]",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Chao Xu",
                "org": "College of Environment, Zhejiang University of Technology, Hangzhou 310014, China"
            },
            {
                "name": "Lili Niu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China"
            },
            {
                "name": "Deliang Zou",
                "org": "College of Environment, Zhejiang University of Technology, Hangzhou 310014, China"
            },
            {
                "name": "Siyu Zhu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China"
            },
            {
                "name": "Weiping Liu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China"
            }
        ],
        "venue": "Science of The Total Environment",
        "year": 2019
    },
    "E8q7BZ8P": {
        "id": "E8q7BZ8P",
        "title": "A new approach to estimate bioavailability of pyrethroids in soil by compound-specific stable isotope analysis.",
        "abstract": "In this study, the microbial degradation of six pyrethroids (bifenthrin, fenpropathrin, permethrin, \u03b1-cypermethrin, fenvalerate and deltamethrin) was investigated in soil to develop a new approach to estimate bioavailability of pyrethoids by compound-specific stable isotope analysis (CSIA). After 56-day incubation, the residual concentrations of pyrethroids in unsterilized soil were much lower than those in sterilized soil, indicating that microbial degradation was dominant for the elimination of pyrethroids. Meanwhile, the stable carbon isotope ratios of the six pyrethroids were determined during the degradation. Significant stable carbon isotope fractionation was observed during the microbial degradation of fenpropathrin, \u03b1-cypermethrin and deltamethrinhe. The enrichment factor \u03b5 was determined as -1.88\u2030, -1.82\u2030 and -2.00\u2030, respectively. A new approach was then developed to estimate the bioavailability of the three pyrethroids by determining stable carbon isotope ratios. The approach established in the study provides an alternative method to dynamically and quantitatively estimate bioavailability of compounds in soil based on CSIA.",
        "keywords": [
            "Bioavailability",
            "Compound-specific stable isotope analysis",
            "Microbial degradation",
            "Pyrethroids",
            "Soil"
        ],
        "authors": [
            {
                "name": "Zemin Xu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China."
            },
            {
                "name": "Weiping Liu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China."
            },
            {
                "name": "Fangxing Yang",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China. Electronic address: fxyang@zju.edu.cn."
            }
        ],
        "venue": "Journal of hazardous materials",
        "year": 2018
    },
    "Eg1kBrJU": {
        "id": "Eg1kBrJU",
        "title": "Inhibitory effects of paraquat on photosynthesis and the response to oxidative stress in Chlorella vulgaris.",
        "abstract": "This study investigated the effects of paraquat, a widely used herbicide, on the aquatic unicellular alga Chlorella vulgaris through short-term toxicity tests at the physiological and gene transcriptional levels. Exposure to 0.5\u00a0\u03bcM paraquat increased\n the activities of the antioxidant enzymes superoxide dismutase, peroxidase, and catalase to levels 4.93, 3.19, and 3.09 times\n higher, respectively, than those of the control. Furthermore, exposure to 0.75\u00a0\u03bcM paraquat increased the activities of these\n antioxidant enzymes to even higher levels. The decrease in chlorophyll content and the increases in reactive oxygen species\n (ROS) and malondialdehyde content following exposure to paraquat suggest that the alga was severely damaged and cell growth\n was greatly inhibited. Real-time PCR showed that paraquat reduced the transcript abundance of psaB and rbcL to 7.09 and 29.83% of the control, respectively. Our results demonstrate that paraquat inhibited electron transport and\n CO2 assimilation, and also triggered the synthesis of ROS that disrupt cellular structure and inhibit cell growth.",
        "keywords": [
            "chlorella vulgaris",
            "gene transcript",
            "paraquat",
            "real-time pcr",
            "electron transport",
            "real time pcr",
            "cell growth",
            "peroxidase",
            "toxicity testing",
            "real time",
            "gene transcription",
            "oxidation",
            "electron transfer",
            "photosynthesis",
            "enzymes",
            "toxicity",
            "oxygen",
            "enzyme activity",
            "carbon dioxide",
            "transcription"
        ],
        "authors": [
            {
                "name": "Haifeng Qian",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Wei Chen",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Liwei Sun",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Yuanxiang Jin",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Zhengwei Fu",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            }
        ],
        "venue": "Ecotoxicology (London, England)",
        "year": 2009
    },
    "tCp8khrz": {
        "id": "tCp8khrz",
        "title": "Determination of ascorbic acid by indirect fluorimetry]",
        "abstract": "Experiments indicated that cerium(IV) ion which could not emit fluorescence was deoxidized by ascorbic acid to cerium(III) ion which could emit its characteristic fluorescence in water solution, while sodium hexametaphosphate added could greatly enhance the fluorescence intensity of the system. From this, an indirect sensitive method for determining ascorbic acid was developed. The fluorescence intensity of the system was measured in a 1 cm quartz cell with the excitation and emission wavelengths of 303 and 340 nm, respectively. The results showed that the fluorescence intensity of the system presented a linear relationship with the concentration of ascorbic acid in the range of 1.0 x 10(-7)-8.0 x 10(-6) mol x L(-1), the correlation coefficient r was 0.9997, and the detection limit (S/N = 3) was 1.6 x 10(-8) mol x L(-1). The presented method was used to determine ascorbic acid sample and vitamin C tablet, and the results were satisfactory.",
        "keywords": [
            "sodium hexametaphosphate",
            "fluorimetry",
            "cerium(\u2173)",
            "ascorbic acid"
        ],
        "authors": [
            {
                "name": "Chang-lun Tong",
                "org": "Institute of Environmental Science, Zhejiang University, Hangzhou 310029, China."
            },
            {
                "name": "Guang-hong Xiang",
                "org": ""
            },
            {
                "name": "Wei-ping Liu",
                "org": ""
            }
        ],
        "venue": "Guang pu xue yu guang pu fen xi = Guang pu",
        "year": 2005
    },
    "MLPpdJon": {
        "id": "MLPpdJon",
        "title": "Distribution of PCDD/Fs in soil samples in vicinity of a simply rural solid waste incinerator",
        "abstract": "The distribution of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) in vicinity of a simply rural solid waste incinerator was evaluated by analysis of six soil samples, a fly ash sample and a residue sample. The range of I-TEQ values for the PCDD/Fs in the soil samples representing the pollution investigation in the study area was 2.29-9.45 ng/kg (dry weight), which means that the level of PCDD/Fs pollution was higher than that of the background (0.537 ng/kg). The I-TEQ values of PCDD/Fs for fly the ash sample and the residue sample were 3 454 and 32.2 I-TEQ ng/kg individually. The principal component analysis shows that the rural solid waste incinerator is not only one source of PCDD/Fs in soil.",
        "keywords": [
            "Fly",
            "PCDD/Fs",
            "Residue",
            "Simply rural solid waste incinerator",
            "Soil"
        ],
        "authors": [
            {
                "name": "LIU Jin-song",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "PAN He-fang",
                "org": "Zhejiang Environmental Monitoring Center(Zhejiang Province Environmental Radiation Monitoring Center,Zhejiang Province Environmental Monitoring Center,Zhejiang Environmental Monitoring Center),Hangzhou,China"
            },
            {
                "name": "FENG Yuan-qun",
                "org": "Zhejiang Environmental Monitoring Center(Zhejiang Province Environmental Radiation Monitoring Center,Zhejiang Province Environmental Monitoring Center,Zhejiang Environmental Monitoring Center),Hangzhou,China"
            },
            {
                "name": "GONG Hong-ping",
                "org": "Zhejiang Environmental Monitoring Center(Zhejiang Province Environmental Radiation Monitoring Center,Zhejiang Province Environmental Monitoring Center,Zhejiang Environmental Monitoring Center),Hangzhou,China"
            }
        ],
        "venue": "Zhejiang Daxue Xuebao(Gongxue Ban)/Journal of Zhejiang University (Engineering Science)",
        "year": 2010
    },
    "OID0I6wj": {
        "id": "OID0I6wj",
        "title": "Temperature and photoperiod affect the endocrine disruption effects of ethinylestradiol, nonylphenol and their binary mixture in zebrafish (Danio rerio).",
        "abstract": "We found that temperature and photoperiod significantly influence the transcription of the estrogen-responsive genes, vitellogenin1 (Vtg1), vitellogenin2 (Vtg2), estrogen receptor-alpha (ER alpha) and estrogen receptor-beta (ER beta), after a 21-day exposure to environmentally relevant concentrations of 17 alpha-ethynylestradiol (EE2), nonylphenol (NP) and EE2 plus NP (EE2+NP). In general, gene transcription levels were higher as temperature and photoperiod length increased. The mRNA levels of Vtg1 in EE2 (10 ng/L) and EE2+NP (10 ng/L and 25 microg/L, respectively) groups were induced more than 10(4) times both in 21 degrees C-12L and 30 degrees C-14L groups, but only 369+/-23 and 178+/-59-fold induced in 12 degrees C-10L group compared to the control, respectively. Specifically, when exposed to a high concentration of NP (25 microg/L) for 21 days, the levels of all mRNAs examined were significantly increased (p<0.05) in the 21 degrees C-12L and the 30 degrees C-14L groups compared to the controls. However, no obvious induction in transcription was observed in the 12 degrees C-10L group. The results obtained in the present study clearly elucidate that temperature and photoperiod greatly influence the effect of EDCs, and thus suggest that to fully define the endocrine disruption effects seasonal and/or climate change effects must also be investigated.",
        "keywords": [
            "endocrine-disrupting effects",
            "gene transcription",
            "temperature and photoperiod",
            "zebrafish",
            "estrogen receptor",
            "climate change",
            "seasonality"
        ],
        "authors": [
            {
                "name": "Yuanxiang Jin",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Linjun Shu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Liwei Sun",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Weiping Liu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Zhengwei Fu",
                "org": ""
            }
        ],
        "venue": "Comparative biochemistry and physiology. Toxicology & pharmacology : CBP",
        "year": 2010
    },
    "aIbzELFj": {
        "id": "aIbzELFj",
        "title": "Simultaneous determination of five nitroaniline and dinitroaniline isomers in wastewaters by solid-phase extraction and high-performance liquid chromatography with ultraviolet detection.",
        "abstract": "A high-performance liquid chromatography (HPLC)-ultraviolet detection method, combined with solid-phase extraction (SPE), was developed for the determination of five nitroaniline and dinitroaniline isomers including 2-nitroaniline, 3-nitroaniline, 4-nitroaniline, 2,4-dinitroaniline and 2,6-dinitroaniline in wastewater samples. Extraction of the five isomers was carried out with a hydrophile-lipophile balance cartridge, the Oasis HLB. The cartridge was washed by a mixed aqueous solution containing 10% (v/v) acetonitrile and 10% (v/v) ethyl acetate before the five isomers were eluted by a mixture of methanol and acetic acid. Separation of the five isomers was achieved by using an Agilent TC-C(18) column at 30\u00b0C, and using a mixture of acetonitrile/water 30/70 (v/v) as mobile phase under an isocratic condition at a flow rate of 1.0 mL/min. The analytes were detected by a UV detector at a wavelength of 225 nm. Recoveries of the five isomers in the spiked sewage sample were between 84.6% and 94.0% with a relative standard deviation of less than 4.7%. The limits of quantification (LOQ) determined in a spiked sewage sample of 500 mL were 2.0 x 10(-9)M for 2-nitroaniline, 3-nitroaniline and 2,6-dinitroaniline, and 4.5 x 10(-9)M for 4-nitroaniline and 2,4-dinitroaniline. The proposed method was applied to determine the five isomers in real samples of acidic wastewater and printing and dyeing wastewater.",
        "keywords": [
            "wastewater",
            "solid-phase extraction (spe)",
            "nitroaniline",
            "high-performance liquid chromatography (hplc)",
            "dinitroaniline"
        ],
        "authors": [
            {
                "name": "Changlun Tong",
                "org": ""
            },
            {
                "name": "Yun Guo",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecological Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310029, China"
            },
            {
                "name": "Weiping Liu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecological Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310029, China"
            }
        ],
        "venue": "Chemosphere",
        "year": 2010
    },
    "relGVOAp": {
        "id": "relGVOAp",
        "title": "Research Advances in the Toxicity of Synthefic Pyrethroid Pesticides to Mammal Nervous Systems",
        "abstract": "The research advances of synthetic pyrethroids(SPs)in the toxicity to mammal nervous systems were reviewed.SPs are widely used in both agricultural and urban environments for insect control.Some studies showed that SPs display toxicity to wildlife and human nervous systems.It may cause acute and chronic neurotoxicity to mammal,and the stereoisomeric structure of SPs affects mammals neurotixicity.There was some enantioselectivity of SPs in acute and chronic neurotoxicity to mammal.",
        "keywords": [
            "neurotoxicity",
            "synthetic pyrethroids",
            "chirality",
            "pesticides"
        ],
        "authors": [
            {
                "name": "HUANG Hai-feng",
                "org": "Research Center of Environmental Science,ZheJiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "ZHOU Bing",
                "org": "Research Center of Environmental Science,ZheJiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "ZHAO Mei-rong",
                "org": "Research Center of Environmental Science,ZheJiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Research Center of Environmental Science,ZheJiang University of Technology,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Pesticide Science",
        "year": 2007
    },
    "M2qt399e": {
        "id": "M2qt399e",
        "title": "Thyroid Disruption by Bisphenol S Analogues via Thyroid Hormone Receptor \u03b2: in Vitro, in Vivo and Molecular Dynamics Simulation Study.",
        "abstract": "Bisphenol S (4-hydroxyphenyl sulfone, BPS) is increasingly used as BPA alternatives. The global usage of BPS and its analogues (BPSs) caused the frequent detection of their residues in multiple environmental media. We investigated their potential endocrine disrupting effects toward thyroid hormone receptor (TR) \u03b2. The molecular interaction of BPSs toward TR\u03b2 ligand binding domain (LBD) was probed by fluorescence spectroscopy and molecular dynamics (MD) simulations. BPSs caused the static fluorescence quenching of TR\u03b2 LBD. The 100 ns MD simulations revealed that the binding of BPSs caused significant changes of the distance between residue His435 at helix 11(H11) and residue Phe459 at H12 in comparison with no ligand-bound TR\u03b2 LBD, indicating relative repositioning of H12. The recombinant two-hybrid yeast assay showed that tetrabromobisphenol S (TBBPS) and tetrabromobisphenol A (TBBPA) have potent antagonistic activity toward TR\u03b2 with IC10 of 10.1 nM, 21.1 nM, respectively. BPS and BPA have the antagonistic activity with IC10 of 312 nM, 884 nM, respectively. BPSs significantly altered the expression level of mRNA of TR\u03b2 gene in zebrafish embryos. BPS and TBBPS at environmentally relevant concentrations have antagonistic activity toward TR\u03b2, implying that BPSs are not safe BPA alternatives in many of the BPA-free products. Future health risk assessment of TR disruption and other adverse effects should focus more on the structure-activity relationship in designing environmentally benign BPA alternatives.",
        "keywords": "",
        "authors": [
            {
                "name": "Liping Lu",
                "org": ""
            },
            {
                "name": "Tingjie Zhan",
                "org": ""
            },
            {
                "name": "Mei Ma",
                "org": ""
            },
            {
                "name": "Chao Xu",
                "org": ""
            },
            {
                "name": "Jingpeng Wang",
                "org": ""
            },
            {
                "name": "Chunlong Zhang",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Shulin Zhuang",
                "org": ""
            }
        ],
        "venue": "Environmental science & technology",
        "year": 2018
    },
    "UWulnNOh": {
        "id": "UWulnNOh",
        "title": "Dynamics of uptake and elimination of pyrethroid insecticides in zebrafish (Danio rerio) eleutheroembryos.",
        "abstract": "Synthetic pyrethroids (SPs) are among the most heavily used insecticides for residential and agricultural applications. Their residues have frequently been detected in aquatic ecosystems. Despite their high aquatic toxicity, their toxicokinetics are still unclear. In this study, the kinetics of uptake and depuration of three SPs, permethrin (PM), bifenthrin (BF) and \u03bb-cyhalothrin (\u03bb-CH), were determined for the first time using zebrafish eleutheroembryo assays. The diastereoisomer selectivity of PM in eleutheroembryos was further examined. The results indicated that three SPs were quickly taken up by eleutheroembryos. The bioaccumulation factors of the SPs ranged from 125.4 to 708.4. The depuration of SPs in zebrafish eleutheroembryos followed the first-order process. The elimination rate constants (k2) of SPs in eleutheroembryos ranged from 0.018 h(-1) to 0.0533 h(-1). The half-lives (t1/2) were in the range 13.0-38.5h. The diastereoisomer fraction (DF) values for PM in the eleutheroembryos estimated at different uptake and depuration times were all significantly greater than the original value (DF=0.43), indicating selective enrichment and elimination of cis-PM relative to trans-PM. These results reveal a high capacity for SP bioconcentration by zebrafish eleutheroembryos, suggesting that SPs possess a highly cumulative risk to fish.",
        "keywords": [
            "bioconcentration factor (bcf)",
            "pyrethroid insecticides",
            "uptake and elimination",
            "zebrafish eleutheroembryo"
        ],
        "authors": [
            {
                "name": "Wenqing Tu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China."
            },
            {
                "name": "Bin Lu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China."
            },
            {
                "name": "Lili Niu",
                "org": "IJRC-PTS, MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Chao Xu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China."
            },
            {
                "name": "Chunmian Lin",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China."
            },
            {
                "name": "Weiping Liu",
                "org": "IJRC-PTS, MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            }
        ],
        "venue": "Ecotoxicology and environmental safety",
        "year": 2014
    },
    "1p3verRB": {
        "id": "1p3verRB",
        "title": "Enantioselectivity in the phytotoxicity of herbicide imazethapyr.",
        "abstract": "Chiral compounds usually behave enantioselectively in phyto-biochemical processes. With the increasing application of chiral herbicides, their enantioselective phytotoxicity to plants merits further study, and little information is available in this area. The purpose of this study was to examine the enantioselective phytotoxicity of the herbicide imazethapyr (IM) on the roots of maize (Zea mays L.) seedlings. Enantiomers of IM were separated by HPLC, and their absolute configurations were confirmed as S-(+)-IM and R-(-)-IM by the octant rule. Plant growth measurements and morphological, microscopic, and ultrastructural observations were conducted after treatment with individual IM enantiomers and the racemate. Observations of root morphology showed that the root diameter significantly increased, whereas the root volume, surface area, and number of root tips decreased significantly. IM enantiomers selectively damaged root hair growth and significantly reduced the sloughing of border cells from the tips. IM also had adverse effects on cell organelles, such as statocytes, mitochondria, dictyosomes, and endoplasmic reticulum in maize roots. Moreover, cell membranes and cell walls were thicker than usual after IM treatment. All of the results showed the same trend that the R-(-)-IM affected the root growth of maize seedlings more severely than the S-(+)-IM. The inhibition abilities of (+/-)-IM was between S-(+)- and R-(-)-IM. The behavior of the active enantiomer, instead of just the racemate, may have more relevance to the herbicidal effects and ecological safety of IM. Therefore, enantiomeric differences should be considered when evaluating the bioavailability of the herbicide IM.",
        "keywords": [
            "statocytes",
            "border cell",
            "cell organelle",
            "root hair",
            "enantioselectivity",
            "enantiomers",
            "growth",
            "plant morphology"
        ],
        "authors": [
            {
                "name": "Qingyan Zhou",
                "org": ""
            },
            {
                "name": "Chao Xu",
                "org": ""
            },
            {
                "name": "Yongsong Zhang",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            }
        ],
        "venue": "Journal of agricultural and food chemistry",
        "year": 2009
    },
    "E4W47yjp": {
        "id": "E4W47yjp",
        "title": "Simultaneous Determination of Enantiomers of Rac-diclofop Methyl and Rac-diclofop Acid in Water by High Performance Liquid Chromatography Coupled with Fluorescence Detection",
        "abstract": "A novel method was developed to simultaneously separate and determine the enantiomers of rac- diclofop methyl and rac-diclofop acid using chiral high performance liquid chromatography (HPLC) coupled with fluorescence detection. Parameters affecting the chiral separation such as the added amounts of isopropanol and acetic acid in the mobile phase, and column temperature were studied. A simultaneous baseline separation of the enantiomers was obtained with a mobile phase of n-hexane/isopropanol/acetic acid ( 90\u223610\u22360.2 , V/V) at a flow rate of 0.5 mL/min under 20\u2103. The proposed method was applied to determine the enantiomers of rac-diclofop methyl and rac-diclofop acid in water. The recoveries of all enantiomers were higher than 85% with relative standard deviations less than 5.0%.",
        "keywords": [
            "chiral pesticide",
            "diclofop acid",
            "Diclofop methyl",
            "chiral separation"
        ],
        "authors": [
            {
                "name": "Lin Kunde",
                "org": "Institute of Environmental Science, Zhejiang University, Hangzhou "
            },
            {
                "name": "Cai Xiyun",
                "org": "Institute of Environmental Science, Zhejiang University, Hangzhou "
            },
            {
                "name": "Chen Shengwen",
                "org": "Institute of Environmental Science, Zhejiang University, Hangzhou "
            },
            {
                "name": "Liu Weiping",
                "org": ""
            }
        ],
        "venue": "Chinese Journal of Analytical Chemistry",
        "year": 2006
    },
    "JTPaz5Za": {
        "id": "JTPaz5Za",
        "title": "Enantioresolution and Study of Thermodynamical Property of Napropamide by High Performance Liquid Chromatography",
        "abstract": "The enantiomer of napropamide was resolved under reverse phase high performance liquid chromatography(HPLC) using Chiralcel(AD-RH) and Chiralcel OD-RH with acetonitrile-water as a mobile phase.The effects of the content of acetonitrile in mobile phase,flow-rate and temperature on the chiral separation of napropamide were studied.The chiral separation mechanism of napropamide enantiomer on the CSPs was analysed by thermodynamical parameters.The results showed that the \u25b3\u25b3H~0 of ADRH and OD-RH chiral column were-1 160.79 J/mol and-673.40 J/mol respectively,namely the stereoselectivity of Chiralcel AD-RH was better than Chiralcel OD-RH and good enantiomeric separations were achieved with both CSPs under the experiment of flow-rate 0.5 mL/min,acetonitrile-water 50 \u223650 in volume and temperature 10\uff5e35\u2103.",
        "keywords": [
            "chiral stationary phase",
            "napropamide",
            "enantiomeric resolution",
            "high performance liquid chromatography"
        ],
        "authors": [
            {
                "name": "ZHOU Ying",
                "org": "Institute of Environmental Science P.O.X,3041,Zhejiang University,Hangzhou ,China;College of Chemical Engineering and Materials Science,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "ZHANG Shi-hao",
                "org": "College of Chemical Engineering and Materials Science,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Institute of Environmental Science P.O.X,3041,Zhejiang University,Hangzhou ,China;College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "CHEN Yi-hui",
                "org": "College of Chemical Engineering and Materials Science,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "YE Li",
                "org": "College of Chemical Engineering and Materials Science,Zhejiang University of Technology,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Pesticide Science",
        "year": 2006
    },
    "4gItHPbx": {
        "id": "4gItHPbx",
        "title": "Enantioselective induction of estrogen-responsive gene expression by permethrin enantiomers in embryo-larval zebrafish.",
        "abstract": "Enantioselectivity in the separation, toxicology, biodegradation and estrogenic activity of chiral pesticides has become a groundbreaking topic recently. In this study, real-time, quantitative polymerase chain reaction was adapted to investigate the induction of estrogen-responsive gene expression in embryo-larval zebrafish after 7 d of exposure to permethrin (PM) enantiomers. The PM enantiomers were completely separated by a chiral HPLC column. The in vivo study found that a 7 d exposure to 250 ng L(-1) PM racemate and its enantiomers was sufficient to stimulate vtg1, esralpha and cyp19b expression, while 1000 ng L(-1) exposure significantly induced gene expression in a pattern similar to that of the control (50 ng L(-1) E2), except for vtg2. Significant differences were detected between the enantiomers in the induction of estrogen-responsive gene expression. At the exposure level of 1000 ng L(-1), the vtg1, esralpha and cyp19b responses to the (-)-trans enantiomer were about 3.2-, 1.8- and 1.5-fold higher, respectively, than those in the group treated with (+)-trans enantiomer (p < 0.05). In the two cis-enantiomer treatment groups, (+)-cis increased the mRNA level of the cyp19b gene about 1.5-fold higher than the (-)-cis-enantiomer did. Of the four enantiomers, the (-)-trans enantiomer showed the greatest estrogenic activity. The results strongly indicate the occurrence of significant enantioselectivity in estrogenic activity of PM enantiomers exposed to embryo-larval zebrafish. These findings add to a growing body of evidence concerning enantioselectivity in the toxicity, endocrine-disrupting activity, and environmental biodegradation of chiral pesticides.",
        "keywords": [
            "enantioselectivity",
            "gene expression",
            "permethrin enantiomers",
            "zebrafish"
        ],
        "authors": [
            {
                "name": "Yuanxiang Jin",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Rujia Chen",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Liwei Sun",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Wanyuan Wang",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Lin Zhou",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Zhengwei Fu",
                "org": ""
            }
        ],
        "venue": "Chemosphere",
        "year": 2009
    },
    "Nvb4g9a8": {
        "id": "Nvb4g9a8",
        "title": "Sorption and degradation of imidacloprid in soil and water.",
        "abstract": "Imidacloprid, the major component of many widely used insecticide formulations, is highly persistent in soils. In this study, the sorption of imidacloprid by six soils as well as its photodegradation and hydrolysis in water were studied. The soils differed significantly in organic matter content and other physical and chemical properties. Sorption increased with increasing soil organic matter content but was not significantly correlated with other soil properties. Removal of organic matter via H2O2 oxidation decreased the sorption. By normalizing the Freundlich coefficients (Kf) to organic matter contents, the variability in obtained sorption coefficient (Kom) was substantially reduced. These results indicate that soil organic matter was the primary sorptive medium for imidacloprid. The low heat of sorption calculated from Kom suggests that partition into soil organic matter was most likely the mechanism. The photodegradation and hydrolysis of imidacloprid in water followed pseudo-first-order kinetics; however, the latter process needed a six-time-higher activation energy. While both processes produced the same main intermediate, they occurred via different pathways. The hydrolysis of imidacloprid was not catalyzed by the high interlayer pH in the presence of metal-saturated clays, which appeared to result from the lack of the pesticide adsorption in the interlayers of clays.",
        "keywords": [
            "photodegradation",
            "soil organic matter",
            "imidacloprid",
            "sorption",
            "pathway",
            "hydrolysis",
            "kinetics",
            "chemical properties",
            "activation energy",
            "first order",
            "organic matter"
        ],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Yun Ma",
                "org": ""
            },
            {
                "name": "Kevin K Liu",
                "org": ""
            }
        ],
        "venue": "Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes",
        "year": 2006
    },
    "MfAa84Ae": {
        "id": "MfAa84Ae",
        "title": "Spatial distributions and enantiomeric signatures of DDT and its metabolites in tree bark from agricultural regions across China.",
        "abstract": "Tree bark is considered as an effective passive sampler for estimating the atmospheric status of pollutants. In this study, we conducted a national scale tree bark sampling campaign across China. Concentration profiles revealed that Eastern China, especially the Jing-Jin-Ji region (including Hebei Province, Beijing and Tianjin) was a hot spot of bark DDT pollution. The enantioselective accumulation of o,p'-DDT was observed in most of the samples and 68% of them showed a preferential depletion of (+)-o,p'-DDT. These results suggest that DDTs in rural bark are likely from combined sources including historical technical DDTs and fresh dicofol usage. The tree bulk DDT levels were found to correlate with soil DDT concentrations, socioeconomy and PM of the sampling sites. It thus becomes evident that the reemission from soils and subsequent atmospheric deposition were the major pathways leading to the accumulation of DDTs in bark. Based on a previously established bark-air partitioning model, the concentrations of DDTs in the air were estimated from measured concentrations in tree bark, and the results were comparable to those obtained by the use of passive sampling with polyurethane foam (PUF) disks. Our results demonstrate the feasibility of delineating the spatial variations in atmospheric concentration and tracing sources of DDTs by integrating the use of tree bark with enantiomeric analysis.",
        "keywords": [
            "Air concentration",
            "DDT",
            "Enantiomer signature",
            "Geographic distribution",
            "Tree bark"
        ],
        "authors": [
            {
                "name": "Lili Niu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China; Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Chao Xu",
                "org": "College of Environment, Zhejiang University of Technology, Hangzhou 310032, China."
            },
            {
                "name": "Chunlong Zhang",
                "org": "Department of Biological and Environmental Sciences, College of Science and Engineering, University of Houston-Clear Lake, Houston, TX 77058, USA."
            },
            {
                "name": "Yuting Zhou",
                "org": "Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Siyu Zhu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Weiping Liu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China; Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: wliu@zju.edu.cn."
            }
        ],
        "venue": "Environmental pollution (Barking, Essex : 1987)",
        "year": 2017
    },
    "vhfXgjAz": {
        "id": "vhfXgjAz",
        "title": "The Metabolic Mechanism of Aryl Phosphorus Flame Retardants by Cytochromes P450: A Combined Experimental and Computational Study on Triphenyl Phosphate.",
        "abstract": "Understanding the metabolic mechanisms is critical and remains a difficult task in risk assessment of emerging pollutants. Triphenyl phosphate (TPHP), one of the widely-used aryl phosphorus flame retardants (aryl-PFRs), has been frequently detected in the environment, whose major metabolite was deemed as diphenyl phosphate (DPHP). However, knowledge of the mechanism for TPHP leading to DPHP and other metabolites is lacking. Our in vitro study shows TPHP is metabolized into its diester metabolite DPHP, and mono-, di-hydroxylated metabolites by cytochromes P450 (CYP) in human liver microsomes, while CYP1A2 and CYP2E1 isoforms are mainly involved in such process. Molecular docking gives the conformation for TPHP binding with the active species Compound I (an iron IV-oxo heme cation radical) in specific CYP isoforms, showing the aromatic ring of TPHP is likely to undergo metabolism. Quantum chemical calculations have shown the dominant reaction channel is O-addition of Compound I onto the aromatic ring of TPHP, followed by hydrogen-shuttle mechanism leading to ortho-hydroxy-TPHP as the main mono-hydroxylated metabolite; the subsequent H-abstraction/OH-rebound reaction acting on ortho-hydroxy-TPHP yields the meta- and ipso-position quinol intermediates, while the former of which can be metabolized into di-hydroxy-TPHP by fast protonation, and the latter species needs to go through type I ipso-substitution and fast protonation to be evolved into DPHP. We envision the identified mechanisms may give inspiration for studying the metabolism of several other aryl-PFRs by CYP.",
        "keywords": "",
        "authors": [
            {
                "name": "Quan Zhang",
                "org": ""
            },
            {
                "name": "Shujing Ji",
                "org": ""
            },
            {
                "name": "Lihong Chai",
                "org": ""
            },
            {
                "name": "Fangxing Yang",
                "org": ""
            },
            {
                "name": "Meirong Zhao",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Gerrit Sch\u00fc\u00fcrmann",
                "org": ""
            },
            {
                "name": "Li Ji",
                "org": ""
            }
        ],
        "venue": "Environmental science & technology",
        "year": 2018
    },
    "ULbGc9dk": {
        "id": "ULbGc9dk",
        "title": "Binding of phenthoate to bovine serum albumin and reduced inhibition on acetylcholinesterase",
        "abstract": "Organophosphorus pesticides (OPs) are of environmental significance due to their high toxicity to animals. Binding to plasma proteins may effective influence the toxicological properties of xenobiotics. In an attempt to evaluate the affinity of phenthoate (PTA) to bovine serum albumin (BSA) and inhibitory ability of bound PTA to acetylcholinesterase (AChE), we investigated the interactions between phenthoate (PTA) and bovine serum albumin (BSA) using tryptophan fluorescence quenching and subsequent inhibition on AChE activity by PTA. The results showed that PTA caused the fluorescence quenching of BSA because of the formation of a PTA\u2013BSA complex. Quenching constants ( K sv ), determined using the Sterns\u2013Volmer equation to provide a measure of the binding affinity between PTA and BSA at 303, 306, 310 and 313 K were (3.4295 \u00b1 0.0763) \u00d7 10 \u22124 , (3.2446 \u00b1 0.0635) \u00d7 10 \u22124 , (3.0434 \u00b1 0.0856) \u00d7 10 \u22124 and (2.8262 \u00b1 0.0569) \u00d7 10 \u22124 M \u22121 , respectively. The thermodynamic parameters, \u0394 H and \u0394 S were \u221225.04 kJ mol \u22121 and 168.94 J mol \u22121 K \u22121 , respectively, which indicated that the electrostatic interactions played a major role in PTA\u2013BSA association. The presence of BSA consistently reduced the inhibitory ability of PTA on AChE, with the relative activity being increased from 46.98 to 61.71% for the concentration range of BSA between 0 and 4.0 g L \u22121 . Keywords Organophosphorus pesticide Bioavailability Fluorescence Phenthoate Bovine serum albumin 1 Introduction Albumin constitutes approximately half of the total blood protein and is the most abundant soluble protein in the body of all vertebrates and the most prominent protein in plasma. It is responsible for the colloidal osmotic pressure of plasma and the maintenance of blood volume. It also supplies most of the acid/base buffering action of plasma proteins in extravascular fluids. Albumin binds and transports metabolites and drugs and is a principal binding protein in blood plasma for a large number of xenobiotics [1] . Interactions of plasma protein and pesticides have a toxicological importance, because it controls the degree and time of pesticidal actions in the body [2] . Furthermore, pesticides bound to albumin can serve as a new biomarker of pesticide exposure in humans [3] . The toxicokinetic behavior of pesticides can be largely dependent on the binding phenomena [4] . Therefore, the protein binding studies are of great importance, although the affinity of pesticides to plasma proteins is often lower than for target enzymes [5] . Organophosphorus pesticides (OPs) are one of the most important classes of insecticides used for protecting crops, livestock, and human health during the past 60 years [6\u20138] . It is estimated that approximately 200 different OPs are currently used commercially worldwide [9] . Almost every person is or has been exposed to OPs in their home or at work as trace dietary contaminants [10] . OPs have a high acute toxicity that results primarily from the inactivation of acetylcholinesterase (AChE) [11] . However, the toxic effects of individual OPs cannot be entirely attributed to the inhibition of target enzymes such as AChE. Some toxicological observations suggest that OPs have other biological actions in their cholinesterase-inhibitory properties [12] . Further studies revealed that toxic signs do not well correlate with the degree of AChE inhibition [13] . The hypothesis thus arose that a given OP reacts not only with AChE, but also with a set of proteins. Experiments with purified albumin in vitro have already demonstrated the covalent binding of albumin to some compounds such as diisopropylfluorophosphate, sarin and soman [14\u201316] . To our knowledge, however, the binding of albumin to PTA and the toxicity of bound PTA have not been reported yet. In this study, we investigated the interactions of PTA with bovine serum albumin (BSA) in vitro using the fluorescence quenching method described by the well-known Stern\u2013Volmer equation [17] . Inhibition of acetylcholinesterase by PTA in the present of BSA was further evaluated; the IC 50 shift induced by BSA was calculated. 2 Materials and methods 2.1 Chemicals BSA (purity >98%) was purchased from BioBasic Company, China. The Tris buffer had a purity of no less than 99.5%. The other chemicals were of analytical purity. Acetylcholine iodide (ATCh-I), 5,5\u2032-dithiobis (2-nitrobenzoic acid) (DTNB), and electric eel acetylcholinesterase (EE AChE; type VI-A) were obtained from Sigma Chemical Co. (St. Louis) and used as received. Phenthoate (PTA) was purified from a technical grade (purity >98%) product of Dafeng Company, China. The BSA samples were dissolved in Tris\u2013HCl buffer solution (0.05 mol L \u22121 Tris, 0.15 mol L \u22121 NaCl, pH 7.4 \u00b1 0.1). 2.2 Spectroscopic measurements Steady-state fluorescence measurements were performed using a spectrophotometer F-2500 (Hitachi, Japan) equipped with 1.0-cm quartz cells and a thermostat bath at various temperatures (303, 306, 310 and 313 K). The 2.0-ml solution containing appropriate concentration of BSA was titrated in the Tris buffer solution (pH 7.40) by successive additions of PTA working solution (the range of PTA concentrations was from 2.0 \u00d7 10 \u22127 to 1.8 \u00d7 10 \u22126 mol L \u22121 ). PTA (total volume 2.0 \u00d7 10 \u22125 L) was added from a concentrated stock solution and its volume increment was thus negligible. Titration was performed manually using a microsyringe. The mixed solution was shaken thoroughly and equilibrated for 1 min before fluorescence was recorded. Care was taken to avoid the presence of significant air bubbles. Tryptophan was excited at 290 nm and emission spectra were recorded at 340 nm. The widths of both the excitation slit and the emission slit were set at 5 nm. Appropriate blanks (i.e., the buffer solution) were subtracted to correct the fluorescence background. A Shimadzu UV-2401PC spectrophotometer was used for measuring the absorbance of albumin solution at excitation and emission wavelengths to evaluate the existing primary and secondary inner filter effects (IFEs). PTA had no emission spectrum between 300 and 450 nm. The inner filter effects were thus neglected. 2.3 AChE activities measurements The AChE activity was spectrophotometrically determined at 37\u00b0C with a Bio-Rad model 680-microplate reader (Bio-Rad Laboratories, Hercules, CA), according to Correll and Ehrich [18] . Briefly, test solutions (20 \u03bcL) at various concentrations of PTA were placed in 500-\u03bcL centrifuge tubes, followed by the addition of 180 \u03bcL of AChE solution. The mixture was incubated at 37\u00b0C for 30 min. Meanwhile, control samples were also prepared using 20 \u03bcL of phosphate buffer (pH 8.0) in place of test solution. DTNB solution (210 \u03bcL) and 20 \u03bcL of ATCh-I solution were added to the wells on a 96-well microtiter plate. Enzyme standard or enzyme-PTA (20 \u03bcL) was subsequently added to make the final concentrations of DTNB and ATCh-I at 0.28 and 0.5 mM, respectively. The enzymatic activities of these mixtures were determined at 405 nm from the addition of enzyme. All the tests and measurements were performed in four replicates. 3 Results and discussion 3.1 Fluorescent characteristics of BSA BSA solution was titrated by PTA stock solution. Fluorescence emission spectra for BSA in the presence of increasing concentrations of PTA were shown in Fig. 1 . PTA caused a decrease in the protein tryptophan fluorescence quantum yield. A slight blue shift (7 nm at 1.8 \u00d710 \u22126 mol L \u22121 ) at the maximum emission wavelength was observed, suggesting that binding of PTA was associated with changes in the dielectric environment of at least one of the two indole rings in BSA [19] . The fluorescence quenching data are usually analyzed by the Stern\u2013Volmer equation [20] : (1) F 0 = F ( 1 + K sv Q ) where F 0 and F are the relative steady-state fluorescence intensities in the absence and presence of quencher (phenthoate), respectively; K sv is the Stern\u2013Volmer quenching constant; Q is the quencher concentration. Fluorescence quenching refers to any process that decreases the fluorescence intensity of a sample. A variety of molecular interactions can result in quenching, including molecular rearrangements, excited-state reactions, energy transfer, ground-state complex formation, and collisional quenching. A linear Stern\u2013Volmer plot ( Fig. 1 b) can be obtained with either collisional static quenching [21] . Collisional quenching is a diffusion-controlled process that occurs when a quencher molecule is within a certain minimal distance from the fluorophore at the time of excitation. In contrast, static quenching results from the formation of a complex between fluorophore and quencher. To differentiate between these quenching mechanisms, temperature effects were investigated. Since higher temperatures result in larger diffusion coefficients, the quenching constants are expected to increase with temperature. In contrast, elevated temperature decreases the stability of complexes and thus lowers the values of the static quenching constants. Table 1 indicates that the quenching mechanism of fluorescence of BSA by PTA is most likely a static quenching procedure. Stern\u2013Volmer quencher constants ( K sv ) were inversely correlated with temperature. According to Table 1 , the quenching data were analyzed by the following modified Stern\u2013Volmer equation [22] : (2) F 0 \u0394 F = 1 f a K a 1 Q + 1 f a where \u0394 F is the difference in fluorescence in the absence and presence of the quencher at concentration Q , f a is the fraction of accessible fluorescence, and K a is the effective quenching constant for the accessible fluorophore. The data in Table 2 indicate that K a was dependent on temperature as described above and that the effect of temperature on binding constant between PTA and BSA was small. The F 0 /\u0394 F is linearly related to the reciprocal value of the quencher concentration (i.e., [ Q ] \u22121 ) with a slope of ( f a K a ) \u22121 . The value f a - 1 is the intercept. The constant K a is a quotient of the ordinate f a - 1 and the slope ( f a K a ) \u22121 . The results at different temperatures are shown in Table 2 . The decreasing trend of K a with increasing temperature is in keeping with K sv \u2019s dependence on temperature as mentioned earlier. It shows that the binding constant between PTA and BSA was moderate and the effect of temperature was small. Thus, PTA can be stored and carried by this protein in the body [23] . 3.2 Determination of the force between PTA and BSA The interaction forces between drugs and biomolecules may include hydrophobic force, electrostatic interactions, van der Waals interactions, hydrogen bonding, steric contacts within antibody-binding sites, etc. To elucidate the interactions between phenthoate and BSA for static quenching, the thermodynamic parameters were calculated from the van\u2019t Hoff plots. Both the enthalpy change (\u0394 H ) and entropy change (\u0394 S ) can be obtained from the following van\u2019t Hoff equation [22] : (3) ln K a = - \u0394 H RT + \u0394 S R The enthalpy change (\u0394 H ) is calculated from the slope of the van\u2019t Hoff equation. The free energy change (\u0394 G ) is then estimated from the following relationship [22] : (4) \u0394 G = \u0394 H - T \u0394 S From the data in Table 2 , Fig. 2 shows the values of \u0394 H and \u0394 S for the binding sites from the slopes and intercepts at the origin of the fitted lines. The negative value of free energy (\u0394 G ) in Table 2 demonstrates that the binding process was spontaneous. The negative enthalpy (\u0394 H ) and positive entropy (\u0394 S ) values for the interactions between PTA and BSA indicate that the electrostatic interactions played a major role in the binding reaction [22] . 3.3 Relationship between BSA concentration and AChE inhibition Inhibition of AChE by PTA in the presence of BSA at various concentrations was further evaluated. The inhibition abilities of PTA to AChE were significantly different in the presence and absence of albumin ( Fig. 3 ). In the reactive system, the relative activities of AChE increased with initial concentration of BSA, which suggests that phenthoate may be partially bound to BSA with a reduced free concentration. The presence of BSA in the system consistently reduced the inhibition of phenthoate to AChE, with the relative activity being increased from 46.98 to 61.71% for the concentration range of BSA. 3.4 The reductive effect of increasing BSA concentrations against phenthoate inhibition to AChE, as assessed by the IC 50 shift IC 50 determinations were done in the absence and presence of BSA at increasing concentrations. Enzyme activities were corrected for BSA induced enzyme activity. The calculated IC 50 values were plotted against BSA concentrations to obtain an IC 50 shift curve. The slope of the shift curve (tg \u03b1 ) was used to quantify the magnitude of the protective effect (mg L \u22121 IC 50 increase per g L \u22121 BSA). The IC 50 shift [tg \u03b1 (mg/g)] has no unit. The IC 50 shift induced by BSA is non-linear. At low concentrations (1.0\u20132.0 g L \u22121 ), tg \u03b1 was small, indicative of a small decreasing effect of BSA. At higher concentrations (2.0\u20134.0 g/L), tg \u03b1 was larger ( Fig. 4 ). Similar phenomena were reported in a previous study [24] . This might be explained on the basis that the number of binding sites at low concentrations were less than at higher concentrations, although the exact mechanism remains to be understood. 4 Conclusions In this paper, we investigated the nature and magnitude of the interactions of PTA with BSA by fluorescence spectroscopy. The results show that the Stern\u2013Volmer quenching constant K sv is inversely correlated with temperature, which indicates that the quenching mechanism of the PTA\u2013BSA binding reaction is probably initiated by complex formation. The free energy change \u0394 G being <0 at various temperatures indicates that the binding process is spontaneous. \u0394 H < 0 and \u0394 S > 0 indicate that the electrostatic force is the major factor in the interaction. Binding of OPs to albumin could serve to scavenge OPs and consequently reduce the amount of OPs reacting with AChE. As the affinity of various OPs for albumin is likely to vary, the effectiveness of albumin as an OP scavenger is likely to depend on the identity of the OP. Acknowledgments The authors wish to thank Kevin K. Liu from Louisianan State University, USA, for help with the experiments and useful suggestions as his summer program. We thank Dafeng Company for providing experimental PTA. References [1] S. Curry H. Mandelkow P. Brick N. Franks Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites Nat. Struct. Biol. 5 1998 827 835 [2] T. Cszerh\u00e1rti E. Forg\u00e1cs Charge transfer chromatographic study of the binding of commercial pesticide to various albumins J. Chromatogr. A 699 1995 285 290 [3] E.S. Peeples L.M. Schopfer E.G. Duysen R. Spaulding T. Voelker C.M. Thompson O. Lockridge Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry Toxicol. Sci. 83 2005 303 312 [4] J. Wilting W.F. van der Giesen L.H.M. Janssen Effect of albumin conformation on the binding of warfarin to human serum albumin J. Biol. Chem. 255 1980 3027 3032 [5] E.J. Ari\u00ebns W. Soudijn P.B.M.W.M. Timmermans Stereochemistry and biological activity of drugs 1983 Blackwell Scientific Publications Oxford pp. 33\u201353 [6] C. Tomlin The pesticide manual 13th ed. 2003 British Crop Protection Council Farnham, UK pp. 1344 [7] M. Eto Organophosphorus pesticides: organic and biological Chemistry 1974 CRC Press Cleveland, OH pp. 387 [8] G.W. Ware The pesticide book fifth ed. 2000 Thomson Publications Fresno, CA pp. 418 [9] C.D. Klaassen Casarett and Doull\u2019s Toxicology fifth ed. 1996 McGraw-Hill New York [10] D.B. Barr R. Bravo G. Weerasekera L.M. Caltabiano R.D. Whitehead Jr. A. Olsson S.P. Caudill Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the U.S. population Environ. Health Perspect. 112 2004 186 200 [11] G.G. Huang O.Y. Ji B.R.G. Willy Y.P. Yang C.J. Tao High-performance liquid chromatographic assay of dichlorvos, phenthoate and methyl parathion from plant leaves using chemiluminescence detection Anal. Chim. Acta 474 2002 21 29 [12] V.C. Moser Comparisons of the acute effects of cholinesterase inhibitors using a neurobehavioral screening battery in rats Neurotoxicol. Teratol. 17 1995 617 625 [13] C.N. Pope Organophosphorus pesticides: Do they all have the same mechanism of toxicity? J. Toxicol. Environ. Health B Crit. Rev. 2 1999 161 181 [14] R.M. Black J.M. Harrison R.W. Read The interaction of sarin and soman with plasma proteins: The identification of a novel phosphorylation site Arch. Toxicol. 73 1999 123 126 [15] G.E. Means H.L. Wu The reactive tyrosine residue of human serum albumin: Characterization of its reaction with diisopropylfluorophosphate Arch. Biochem. Biophys. 194 1979 526 530 [16] M. Schwartz Aserine protease activity of human serum albumin towards 4-methylumbelliferyl-guanidinobenzoate (MUGB) and diisopropyl fluorophosphates (DEP): Implications for the use of MUGB reactivity in amniotic fluid in prenatal diagnosis of cystic fibrosis Clin. Chim. Acta 124 1982 213 223 [17] J.R. Lakowicz Principles of fluorescence spectroscopy second ed. 1999 Plenum Press New York pp. 237\u2013265 [18] L. Correll M. Ehrich A microassay method of neurotoxic esterase determination Fund. Appl. Toxicol. 16 1991 110 116 [19] J.S. Ohansson Binding of the volatile anesthetic chloroform to albumin demonstrated using tryptophan fluorescence quenching J. Biol. Chem. 272 1997 17961 17965 [20] W.M. Vaughan G. Weber Oxygen quenching of pyrenebutyric acid fluorescence in water: a dynamic probe of the microenvironment Biochem 9 1970 9464 9473 [21] J.R. Lakowicz Principles of fluorescence spectroscopy 1983 Plenum Press New York [22] D.T. Haynie Biological thermodynamics 2001 Cambridge University press Cambridge pp. 73\u2013117 [23] Y.J. Hu Y. Liu Z.B. Pi S.S. Qu Interaction of cromolyn sodium with human serum albumin: A fluorescence quenching study Bioorg. Med. Chem. 13 2005 6609 6614 [24] S.J. Uddin J.A. Shilpi G.M.M. Murshid A.A. Rahman M.M. Sarder M.A. Alam Determination of the binding sites of arsenic on bovine serum albumin using warfarin (site-I specific probe) and diazepam (site-II specific probe) J. Biol. Sci. 4 2004 609 612",
        "keywords": [
            "bioavailability",
            "bovine serum albumin",
            "fluorescence",
            "organophosphorus pesticide",
            "phenthoate",
            "plasma proteins",
            "binding affinity",
            "fluorescence quenching"
        ],
        "authors": [
            {
                "name": "Chao Xu",
                "org": "Research Center of Green Chirality, College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, PR China"
            },
            {
                "name": "Anping Zhang",
                "org": "Research Center of Green Chirality, College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, PR China"
            },
            {
                "name": "Weiping Liu",
                "org": ""
            }
        ],
        "venue": "Pesticide Biochemistry and Physiology",
        "year": 2007
    },
    "StJVV2dm": {
        "id": "StJVV2dm",
        "title": "Residue patterns of currently, historically and never-used organochlorine pesticides in agricultural soils across China and associated health risks.",
        "abstract": "Organochlorine pesticides (OCPs) with different usage states, such as currently, historically or never used, may show different behaviors and potential risks in the environment. It is essential to identify their distribution patterns and fates and to assess their associated health risks to humans. In this study, based on a nationwide sampling campaign across China, we determined the concentrations of currently (endosulfan), historically (chlordane and heptachlor) and never-used (aldrin, dieldrin and endrin) OCPs in agricultural soils. The total residue inventories of \u2211Endosulfans, \u2211Chlordanes, heptachlor and \u2211Drins in soils were 260, 64.3, 54.2 and 88.6\u00a0t, respectively. The residues of endosulfan were influenced by current usage, showing a latitude transect trend. Drins were mainly from long-range transport, but the illegal usage in China still affected their residues. This finding indicates that endosulfan and drins in Chinese agricultural soils mainly follow the primary and secondary distribution pattern, respectively. Both primary and secondary distribution have a great impact on the distribution pattern of chlordane, which had been banned for only 4\u00a0years\u00a0at the time we sampled. The health risks of these OCPs were estimated based on their concentrations. There were 0.813% and 1.63% of samples that exceeded the target values for chlordane and endrin according to the Netherlands guideline for unpolluted soil. Their residues in most of the samples posed no or few non-carcinogenic and carcinogenic risks to human beings. The results from this study will provide powerful support for pollution control and management.",
        "keywords": [
            "Agricultural soils",
            "Chlordane",
            "Drin",
            "Endosulfan",
            "Health risk"
        ],
        "authors": [
            {
                "name": "Lili Niu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Chao Xu",
                "org": "College of Environment, Zhejiang University of Technology, Hangzhou 310032, China."
            },
            {
                "name": "Siyu Zhu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Weiping Liu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: wliu@zju.edu.cn."
            }
        ],
        "venue": "Environmental pollution (Barking, Essex : 1987)",
        "year": 2016
    },
    "sYFZzWxT": {
        "id": "sYFZzWxT",
        "title": "A heavy haze episode in Beijing in February of 2014: Characteristics, origins and implications",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "renchang yan",
                "org": ""
            },
            {
                "name": "shaocai yu",
                "org": ""
            },
            {
                "name": "qingyu zhang",
                "org": ""
            },
            {
                "name": "pengfei li",
                "org": ""
            },
            {
                "name": "si wang",
                "org": ""
            },
            {
                "name": "bixin chen",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            }
        ],
        "venue": "Atmospheric Pollution Research",
        "year": 2015
    },
    "mk6CkWxI": {
        "id": "mk6CkWxI",
        "title": "Effects of methyl-CD and humic acid on hydrolytic degradation of the herbicide diclofop-methyl.",
        "abstract": "Hydrolytic degradation of the herbicide diclofop-methyl was investigated in the multi-pH deionized water, natural aquatic systems and soil suspensions. Resulting data indicated that the herbicide was stable in the acidic and nearly neutral solutions for at least 15 d. The herbicide diclofop-methyl rapidly dissipated in the natural aquatic systems and soil suspensions with half-lives less than 4 d. Methyl-CD (partially methylated beta-cyclodextrin) improved its hydrolytic degradation in the pH 8 deionized water and natural aquatic systems while humic acid inhibited its hydrolytic degradation at the same conditions. But dissolved organic matter in the natural aquatic systems and soil suspensions increased its hydrolysis. Two catalysis mechanisms were introduced to describe the effects of cyclodextrin and organic matter on its hydrolytic metabolism. Though inorganic ions maybe improved its hydrolysis reaction in the natural aquatic systems, Fe2+ and Cu2+ did not form complexes with the herbicide and had poor influences on its hydrolytic degradation whether cyclodextrin was added or not.",
        "keywords": [
            "organic matter",
            "diclofop-methyl",
            "hydrolysis",
            "humic acid",
            "methyl-cd"
        ],
        "authors": [
            {
                "name": "Xi-yun Cai",
                "org": "Institute of Environment Science, Zhejiang University, Hangzhou 310029, China."
            },
            {
                "name": "Yue-zhong Wen",
                "org": ""
            },
            {
                "name": "Tian-xiang Zhong",
                "org": ""
            },
            {
                "name": "Wei-ping Liu",
                "org": ""
            }
        ],
        "venue": "Journal of environmental sciences (China)",
        "year": 2005
    },
    "z56MBJXZ": {
        "id": "z56MBJXZ",
        "title": "Occurrence and geographic distribution of polycyclic aromatic hydrocarbons in agricultural soils in eastern China.",
        "abstract": "Polycyclic aromatic hydrocarbons (PAHs) in agricultural soils, eastern China, were studied through a collection of surface samples at 109 sites. The study covered US EPA priority pollutants but also several non-priority isomers including some dibenzopyrenes which are expected to have higher toxic potentials. The total PAH concentrations varied extensively from 8.8 to 3880\u00a0\u03bcg/kg, with a geometric mean of 158\u00a0\u03bcg/kg. There were significant differences in both the concentrations and composition profiles between the south and the north regions. The overall geographical distribution pattern was strongly influenced by both the per capita gross domestic product and soil organic carbon (SOC) content. The former is an indicator of anthropogenic emissions while soil SOC content is associated with the accumulative capacities of the soils. The sequestration mechanism is an important process controlling fates of PAHs in agricultural soil.",
        "keywords": [
            "Agricultural soil",
            "Eastern China",
            "Polycyclic aromatic hydrocarbons",
            "Soil organic carbon"
        ],
        "authors": [
            {
                "name": "Zhe Sun",
                "org": "College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China."
            },
            {
                "name": "Jing Liu",
                "org": "College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China."
            },
            {
                "name": "Shaojie Zhuo",
                "org": "College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China."
            },
            {
                "name": "Yuanchen Chen",
                "org": "College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China."
            },
            {
                "name": "Yanyan Zhang",
                "org": "College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China."
            },
            {
                "name": "Huizhong Shen",
                "org": "College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China."
            },
            {
                "name": "Xiao Yun",
                "org": "College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China."
            },
            {
                "name": "Guofeng Shen",
                "org": "College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China. gfshen12@gmail.com."
            },
            {
                "name": "Weiping Liu",
                "org": "College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China."
            },
            {
                "name": "Eddy Y Zeng",
                "org": "School of Environment, Jinan University, Guangzhou, 510632, China."
            },
            {
                "name": "Shu Tao",
                "org": "College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China. taos@pku.edu.cn."
            }
        ],
        "venue": "Environmental science and pollution research international",
        "year": 2017
    },
    "qGMx4xk9": {
        "id": "qGMx4xk9",
        "title": "Status of phthalate esters contamination in agricultural soils across China and associated health risks.",
        "abstract": "The extensive utilization of phthalate-containing products has lead to ubiquitous contamination of phthalate esters (PAEs) in various matrices. However, comprehensive knowledge of their pollution in Chinese farmland and associated risks is still limited. In this study, 15 PAEs were determined in soils from agricultural fields throughout the Mainland China. The concentrations of \u03a315PAEs were in the range of 75.0-6369\u00a0\u03bcg\u00a0kg(-1). Three provinces (i.e., Fujian, Guangdong and Xinjiang, China) showed the highest loadings of PAEs. Bis(2-Ethylhexyl) phthalate (DEHP) was found as the most abundant component and contributed 71.5% to the \u221115PAEs. The major source of PAEs in arable soils was associated with the application of agricultural plastic films, followed by the activities for soil fertility. Furthermore, the non-cancer and carcinogenic risks of target PAEs were estimated. The hazard indexes (HIs) of PAEs in all samples were below 1 and the carcinogenic risk levels were all within 10(-4). Results from this study will provide valuable information for Chinese agricultural soil management and risk avoidance.",
        "keywords": [
            "agricultural soil",
            "human health risk",
            "phthalate ester",
            "potential source",
            "spatial distribution"
        ],
        "authors": [
            {
                "name": "Lili Niu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Yang Xu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Chao Xu",
                "org": "IJRC-PTS, College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China."
            },
            {
                "name": "Lingxiang Yun",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Weiping Liu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. "
            }
        ],
        "venue": "Environmental pollution (Barking, Essex : 1987)",
        "year": 2014
    },
    "SB77wvFI": {
        "id": "SB77wvFI",
        "title": "Magnetic lanthanide oxide catalysts: an application and comparison in the heterogeneous catalytic ozonation of diethyl phthalate in aqueous solution",
        "abstract": "",
        "keywords": [
            "dep"
        ],
        "authors": [
            {
                "name": "junliang wang",
                "org": ""
            },
            {
                "name": "yuanyang lou",
                "org": ""
            },
            {
                "name": "chao xu",
                "org": ""
            },
            {
                "name": "shuang song",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            }
        ],
        "venue": "Separation and Purification Technology",
        "year": 2015
    },
    "7FsKKjWz": {
        "id": "7FsKKjWz",
        "title": "Dissipation and Enantioselective Degradation of Plant Growth Retardants Paclobutrazol and Uniconazole in Open Field, Greenhouse, and Laboratory Soils",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "anping zhang",
                "org": ""
            },
            {
                "name": "jianqiang sun",
                "org": ""
            },
            {
                "name": "chengwang wu",
                "org": ""
            }
        ],
        "venue": "Environmental Science & Technology",
        "year": 2013
    },
    "6aGUr2FT": {
        "id": "6aGUr2FT",
        "title": "Levels and patterns of DDTs in maternal colostrum from an island population and exposure of neonates",
        "abstract": "",
        "keywords": [
            "exposure assessment"
        ],
        "authors": [
            {
                "name": "chenye xu",
                "org": ""
            },
            {
                "name": "mengling tang",
                "org": ""
            },
            {
                "name": "honghui zhang",
                "org": ""
            },
            {
                "name": "chunlong zhang",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            }
        ],
        "venue": "Environmental Pollution",
        "year": 2016
    },
    "9E2a7r7L": {
        "id": "9E2a7r7L",
        "title": "Photoperiod and temperature influence endocrine disruptive chemical-mediated effects in male adult zebrafish.",
        "abstract": "Potential adverse effects of endocrine-disrupting chemicals (EDCs) in human and wildlife have become a major research topic. However, little is known about the effects of ambient conditions, including temperature and photoperiod, on endocrine disruption in zebrafish. We found that zebrafish hepatic estrogen-responsive gene transcription levels were greatly affected by temperature and photoperiod. Estrogen-responsive gene transcription levels at higher temperatures and with longer photoperiods were significantly higher than those at lower temperatures and with shorter photoperiods upon exposure to 17beta-estradiol (E2) or nonylphenol (NP). Specifically, mRNA expression levels of vitellogenin 1 (vtg1) and vitellogenin 2 (vtg2) induced by both E2 and NP at high temperature (30 degrees C) were approximately 2-10 and 1.5-2.5 times higher than those exposed to low temperature (20 degrees C) under identical photoperiod conditions. mRNA expression levels of vtg1, vtg2 and estrogen receptor alpha (esralpha) with a long photoperiod (16L) were also several folds higher than those with a short photoperiod (8L) upon exposure to E2 and NP at both high and low temperatures. Two-way analysis of variance revealed a significant interaction between temperature and photoperiod in hepatic vtg1 and esralpha gene transcription in both high and low concentration treatment groups upon exposure to E2. However, no significant interactions were found for hepatic estrogen-responsive gene transcription at either NP concentrations. These results suggest that temperature and photoperiod could confound the risk assessment of estrogenic chemicals, and they also have potential implications for future environmental monitoring studies.",
        "keywords": [
            "zebrafish",
            "temperature",
            "endocrine disrupting effects",
            "photoperiod",
            "gene transcription",
            "transcription",
            "endocrine system",
            "genes",
            "messenger rna",
            "gene expression",
            "estrogen receptor",
            "risk assessment",
            "analysis of variance",
            "environmental monitoring",
            "adverse effect"
        ],
        "authors": [
            {
                "name": "Yuanxiang Jin",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, No. 18, Chaowang Road, Hangzhou 310032, China"
            },
            {
                "name": "Rujia Chen",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, No. 18, Chaowang Road, Hangzhou 310032, China"
            },
            {
                "name": "Liwei Sun",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, No. 18, Chaowang Road, Hangzhou 310032, China"
            },
            {
                "name": "Weiping Liu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, No. 18, Chaowang Road, Hangzhou 310032, China"
            },
            {
                "name": "Zhengwei Fu",
                "org": ""
            }
        ],
        "venue": "Aquatic toxicology (Amsterdam, Netherlands)",
        "year": 2009
    },
    "h6FmGaQt": {
        "id": "h6FmGaQt",
        "title": "Enantioseparation of four amide herbicide stereoisomers using high-performance liquid chromatography.",
        "abstract": "The chirality of herbicides has been the focus of research. However, there is little information on the enantioseparation of amide herbicides with different chiral elements. In this study, the need for different chiral stationary phases (CSPs), mobile phases, temperatures and flow rates for the separation of napropamide, acetochlor and propisochlor was discussed in detail and compared to metolachlor. Resolution of C-chiral enantiomers was easier than that of axial-chiral enantiomers. Metolachlor and acetochlor could achieve baseline separation only on AY-H and AS-H columns, respectively. Propisochlor had satisfactory separations on OD-H and AS-H columns. Napropamide was separated on OJ-H, AY-H and AS-H columns. Both the structures of the compounds and CSPs and the interactions between them played significant roles in the enantioseparations. Molecule dockings were also used to elucidate the separation mechanisms. C-chiral enantiomers had perfect symmetry in their optical properties, whereas the axial-chiral enantiomers did not. The elution order for napropamide, acetochlor and propisochlor, with a single chiral location, was R- prior to S-. These results were the first that compare the enantioseparations of four amide herbicides with different chirality, and they provided the absolute configurations for the herbicides. The paper also illustrated certain mechanisms for enantioseparations.",
        "keywords": [
            "Absolute configuration",
            "Amide herbicides",
            "Chirality",
            "Enantioseparation",
            "Separation mechanisms"
        ],
        "authors": [
            {
                "name": "Jingqian Xie",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Lu Zhao",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Kai Liu",
                "org": "Division of Engineering and Applied Science, W. M. Keck Laboratories, California Institute of Technology, 1200 East California Blvd., Pasadena, CA, 91125, USA."
            },
            {
                "name": "Fangjie Guo",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Weiping Liu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: wliu@zju.edu.cn."
            }
        ],
        "venue": "Journal of chromatography. A",
        "year": 2016
    },
    "3WaiAvET": {
        "id": "3WaiAvET",
        "title": "Increasing the activity and stability of chemi-deposited palladium catalysts on nickel foam substrate by electrochemical deposition of a middle coating of silver",
        "abstract": "The objective of this study was to enhance the activity and stability of the chemi-deposited palladium/nickel foam (Pd/Ni foam) electrode used in the electrochemical dechlorination process. The electrochemical deposition of silver onto a nickel foam substrate (Ag/Ni foam) was applied before the chemical deposition of palladium. The physicochemical properties of the resultant material (Pd/Ag/Ni foam) were characterized by X-ray diffraction and scanning electron microscopy. The results showed that the silver coating was in the form of spherical apophyses, and the palladium was dispersed finely on the surface of the Ag/Ni foam. Dichloroacetic acid was selected as an indicator to evaluate the activity and stability of the palladium catalyst. Pd/Ag/Ni foam electrode consistently had relatively higher dechlorination rate and current efficiency (CE) in the current density range of 1.5\u201310.5 mA cm \u22122 compared to the Pd/Ni foam electrode. Quantitative analysis of the main intermediates and final products involving monochloroacetic acid, acetic acid and the chloride ion further demonstrated the enhancement of electrochemical dechlorination by the presence of silver. Moreover, after five cycles of dechlorination, the CE for the Pd/Ni foam electrode decreased dramatically from 67% to 13%, whereas that for the Pd/Ag/Ni foam electrode was decreased by much less, from 78% to 62%, and the palladium loss was clearly reduced by the addition of a silver coating between the Ni foam and the Pd outer layer. Keywords Electrochemical dechlorination Palladium Silver Nickel foam Dichloroacetic acid",
        "keywords": [
            "Dichloroacetic acid",
            "Electrochemical dechlorination",
            "Nickel foam",
            "Palladium",
            "Silver"
        ],
        "authors": [
            {
                "name": "Zhiqiao He",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, PR China"
            },
            {
                "name": "Liyong Zhan",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, PR China"
            },
            {
                "name": "Qiong Wang",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, PR China"
            },
            {
                "name": "Shuang Song",
                "org": ""
            },
            {
                "name": "Jianmeng Chen",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, PR China"
            },
            {
                "name": "Kairan Zhu",
                "org": "College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, PR China"
            },
            {
                "name": "Xinhua Xu",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": "College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, PR China"
            }
        ],
        "venue": "Separation and Purification Technology",
        "year": 2011
    },
    "ogfP8Y6J": {
        "id": "ogfP8Y6J",
        "title": "Enantioselective physiological effects of the herbicide diclofop on cyanobacterium Microcystis aeruginosa.",
        "abstract": "Water blooms caused by cyanobacteria are currently major global environmental issues. The outbreaks induced by nutrient elements have attracted much attention; however, the effects of environmental pollutants on the cyanobacteria are themselves poorly understood, especially those due to chiral chemicals. To explore the enantioselective eco-effects of the chiral herbicide diclofop-methyl (DM) and its major metabolite diclofop acid (DA), the physiological characteristics of Microcystis aeruginosa were investigated. The results showed that using both biomass and protein content as growth parameters is necessary to access the impact of the herbicides, that stimulation biomass production by R-DA and S-DA was apparent (nonessential), and that the concentration of 5 mg/L is worth noting. Ultrastructure changes in gas vacuoles, thylakoids, glycogen, cyanophycin granules, poly beta-hydroxybutyrate, polyhedral body, and lipids indicated different toxicity modes among the four chemicals. The different effects between R-DA and S-DA demonstrated that R-DA probably acts as a proton ionophore shuttling protons across the plasmalemma, whereas S-DA did not demonstrate such action. The toxicity order in the present study is S-DA < R-DA < DM < DA. Stimulation of the growth of M. aeruginosa during the first 3 days by herbicidally inactive S-DA was greater than that due to R-DA, which is adverse to water quality in water bodies. Therefore, using the herbicidally active R-enantiomer is recommended. These results are helpful in understanding the enantioselective effects of chiral pesticides on cyanobacteria, which is important for environmental assessment and protection. It is also helpful for guiding the application of chiral pesticides in agricultural settings.",
        "keywords": [],
        "authors": [
            {
                "name": "Jing Ye",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Lumei Wang",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Zhijian Zhang",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Environmental science & technology",
        "year": 2013
    },
    "h0g9rvSv": {
        "id": "h0g9rvSv",
        "title": "Characterization of napropamide enantiomers by CD and determination of the enantiomeric ratios in water",
        "abstract": "The enantiomers of napropamide were separated by normal phase HPLC (HPLC: high performance liquid Chromatography) with Chiralpak OJ-H column and charactered by circular dichroism. On this basis, a method for the chiral separation and micro-determination of napropamide in water was established. The linearity of calibration curve for racemic mixture was 10-100 ng x mL(-1) and the correlation coefficient was 0. 99. When 10 microL was injected, the detection limit of racemic mixture was 8 ng mL(-1), and the detection limits of both enantiomers were 4 ng x mL(-1).",
        "keywords": [
            "Circular dichroism",
            "Enantioseparation",
            "Fluorescence",
            "Napropamide"
        ],
        "authors": [
            {
                "name": "Sheng-Wen Chen",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Xi-Yun Cai",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Meng Xi",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "An-Ping Zhang",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Wei-Ping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis",
        "year": 2006
    },
    "n5tiu8Cb": {
        "id": "n5tiu8Cb",
        "title": "Cloning of a novel nicotine oxidase gene from Pseudomonas sp. strain HZN6 whose product nonenantioselectively degrades nicotine to pseudooxynicotine.",
        "abstract": "Pseudomonas sp. strain HZN6 utilizes nicotine as its sole source of carbon, nitrogen, and energy. However, its catabolic mechanism has not been elucidated. In this study, self-formed adaptor PCR was performed to amplify the upstream sequence of the pseudooxynicotine amine oxidase gene. A 1,437-bp open reading frame (designated nox) was found to encode a nicotine oxidase (NOX) that shows 30% amino acid sequence identity with 6-hydroxy-l-nicotine oxidase from Arthrobacter nicotinovorans. The nox gene was cloned into a broad-host-range cloning vector and transferred into the non-nicotine-degrading bacteria Escherichia coli DH5\u03b1 (DH-nox) and Pseudomonas putida KT2440 (KT-nox). The transconjugant KT-nox obtained nicotine degradation ability and yielded an equimolar amount of pseudooxynicotine, while DH-nox did not. Reverse transcription-PCR showed that the nox gene is expressed in both DH5\u03b1 and KT2440, suggesting that additional factors required for nicotine degradation are present in a Pseudomonas strain(s), but not in E. coli. The mutant of strain HZN6 with nox disrupted lost the ability to degrade nicotine, but not pseudooxynicotine. These results suggested that the nox gene is responsible for the first step of nicotine degradation. The (RS)-nicotine degradation results showed that the two enantiomers were degraded at approximately the same rate, indicating that NOX does not show chiral selectivity. Site-directed mutagenesis revealed that both the conserved flavin adenine dinucleotide (FAD)-binding GXGXXG motif and His456 are essential for nicotine degradation activity.",
        "keywords": [
            "biotransformation",
            "escherichia coli",
            "gene expression profiling",
            "amino acid sequence"
        ],
        "authors": [
            {
                "name": "Jiguo Qiu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Yun Ma",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Jing Zhang",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Yuezhong Wen",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Applied and environmental microbiology",
        "year": 2013
    },
    "151bv6XD": {
        "id": "151bv6XD",
        "title": "Enantioselective degradation of 2, 4-dichlorprop methyl ester by sediment bacteria]",
        "abstract": "Enantioselective Degradation of 2,4-Dichlorprop methyl ester was studied by sediment bacteria. One DCPPM-degrading bacteria stain was isolated from contaminated sediments. The EF values were determined by chiral GC. The enantioselectivity of DCPPM biodegradation in aquatic phases were evaluated. Incubation with DCPPM-degrading bacteria show that the R enantiomer was preferentially degraded over the corresponding S enantiomer of DCPPM. The EF values show a much higher deviation. It indicate that the microbial degradation of DCPPM was enantioselectivety.",
        "keywords": [
            "biodegration",
            "enantioselectivity",
            "sediment",
            "dichlorprop methyl ester"
        ],
        "authors": [
            {
                "name": "Yun Ma",
                "org": "Institute of Environmental Science, Zhengjiang University, Hangzhou 310029, China."
            },
            {
                "name": "Chao Xu",
                "org": ""
            },
            {
                "name": "Sheng-Wen Chen",
                "org": ""
            },
            {
                "name": "Yue-Zhong Wen",
                "org": ""
            },
            {
                "name": "Wei-Ping Liu",
                "org": ""
            }
        ],
        "venue": "Huan jing ke xue= Huanjing kexue / [bian ji, Zhongguo ke xue yuan huan jing ke xue wei yuan hui \"Huan jing ke xue\" bian ji wei yuan hui.]",
        "year": 2005
    },
    "ZFydyAJQ": {
        "id": "ZFydyAJQ",
        "title": "Degradation and detoxification of acetochlor in soils treated by organic and thiosulfate amendments.",
        "abstract": "This work investigated the degradation and detoxification of acetochlor in a soil amended with an organic fertilizer or sodium thiosulfate (STS). Over an incubation period of 28 d, the residual acetochlor was measured, soil dehydrogenase activity was determined, and major degradates were identified. Results show that high-concentration acetochlor was persistent in the soil, as indicated by the depression in soil dehydrogenase activity. When the soil was amended with the organic fertilizer, the soil dehydrogenase activity was stimulated by supplemented nutrients, which resulted in a higher degradation of acetochlor. While STS did not significantly stimulate the soil dehydrogenase activity, acetochlor degraded more rapidly in STS-amended soil than in organic-amended soil. The Wright-Hobbie plots show that the influence of initial acetochlor concentration on degradation was dependent on the amendments. While the organic amendment resulted in the same degradate of acetochlor ethanesulfonic acid as in unamended soil, the STS amendment produced dechlorinated acetochlor thiosulfonic acid. The degradation of acetochlor in organic- and STS-amended soils thus occurred via different mechanisms. Further tests show that both degradates were less toxic to green algae than acetochlor. Both organic and STS amendments thus effectively degrade and detoxify acetochlor in soils.",
        "keywords": [
            "degradation",
            "organic fertilizer",
            "acetochlor",
            "thiosulfate",
            "detoxification",
            "soil"
        ],
        "authors": [
            {
                "name": "Xiyun Cai",
                "org": "Institute of Environmental Science, Zhejiang University, Hangzhou 310029, China"
            },
            {
                "name": "Guangyao Sheng",
                "org": "Research Center of Green Chirality, College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Weiping Liu",
                "org": ""
            }
        ],
        "venue": "Chemosphere",
        "year": 2007
    },
    "83LPNjQH": {
        "id": "83LPNjQH",
        "title": "Overviews of Mercury Emission from Coal Combustion in China and Technology of Mercury-removing by Activated Carbon",
        "abstract": "Combustion of coal that is the most important energy source in China has been producing immense air pollution including mercury pollution.Recently,mercury pollution control has been put on the agenda according to the 12th Five-Year Planning.This paper reviews the status of mercury pollution caused by coal-fire industry in China,the related health risks and the technology to control mercury emission,which has been gradually developed especially in the coal-fire power plant.Techniques to remove Hg from flue gas including conventional activated carbon and modified activated carbon,as well as the adsorption and desorption/regeneration mechanisms are introduced;and on the basis of the technology review prospects for improving mercury control in terms of strategy and technology are discussed as well.",
        "keywords": [
            "activated carbon",
            "control technology",
            "coal combustion",
            "adverse effect",
            "mercury"
        ],
        "authors": [
            {
                "name": "NIU Li-li",
                "org": "College of Environment and Resource,Zhejiang University,Hangzhou ,China"
            },
            {
                "name": "XU Chao",
                "org": "College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "College of Environment and Resource,Zhejiang University,Hangzhou ,China"
            }
        ],
        "venue": "Environmental Science & Technology",
        "year": 2012
    },
    "7dqRR1do": {
        "id": "7dqRR1do",
        "title": "Cytotoxicity evaluation of three pairs of hexabromocyclododecane (HBCD) enantiomers on Hep G2 cell.",
        "abstract": "Hexabromocyclododecanes (HBCDs) are additive brominated flame retardants mainly used in plastics and textiles. At the present time, these compounds are found in almost all environmental and human samples. In order to evaluate the environmental safety and health risk of HBCDs, the enantiomerically pure alpha-, beta-, and gamma-HBCD were prepared using high performance liquid chromatography (HPLC) on a PM-beta-CD column and the cytotoxicities of their enantiomers were evaluated in Hep G2 cells. Results from the 3-(4,5-dimethylthioazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT), resazurin reduction and lactate dehydrogenase (LDH) release assays showed a good agreement that the order of cytotoxicity was gamma-HBCDbeta-HBCD>alpha-HBCD, and that significantly lower cell viability and higher LDH release were observed in all (+)-enantiomers ((+) alpha-, (+) beta- and (+) gamma-HBCD) than the corresponding (-)-forms ((-) alpha-, (-) beta- and (-) gamma-HBCD). Additionally, the formation of reactive oxygen species (ROS) induced by these HBCD enantiomers were detected. The positive correlation between the LDH release and ROS formation demonstrated that the toxic mechanism might be mediated by oxidative damage. These results suggest that environmental and human health risks of HBCDs must be evaluated at the level of individual enantiomers.",
        "keywords": [
            "hexabromocyclododecanes",
            "enantiomers",
            "diastereomers",
            "cytotoxicity",
            "reactive oxygen species",
            "high performance liquid chromatography",
            "cell viability"
        ],
        "authors": [
            {
                "name": "Xiaoling Zhang",
                "org": "Graduate University of Chinese Academy of Sciences, Beijing 100049, China"
            },
            {
                "name": "Fangxing Yang",
                "org": "State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, 7# Donghu South Road, Wuhan 430072, China"
            },
            {
                "name": "Chao Xu",
                "org": "Research Center of Environmental Science, College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, PR China"
            },
            {
                "name": "Weiping Liu",
                "org": "Research Center of Environmental Science, College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, PR China"
            },
            {
                "name": "Sheng Wen",
                "org": "Graduate University of Chinese Academy of Sciences, Beijing 100049, China"
            },
            {
                "name": "Ying Xu",
                "org": ""
            }
        ],
        "venue": "Toxicology in vitro : an international journal published in association with BIBRA",
        "year": 2008
    },
    "582929x7": {
        "id": "582929x7",
        "title": "Time-dependent degradation and toxicity of diclofop-methyl in algal suspensions",
        "abstract": "Background, aim, and scope\u00a0\u00a0As emerging contaminants, transformation products of the pollutants via various environmental processes are rather unknown,\n and some may predominately contribute to the environmental risks of the parent compounds. Hence, studies on transformation\n products complement the assessment of the environmental safety of the parent compounds. In this study, degradation experiments\n and toxicity tests using diclofop-methyl (DM), a widely used herbicide, and selected major transformation products were carried\n out in algal cultures to assess the time course of DM toxicity and its relevance in the formation of new breakdown products.\n \n \n \n Methods\u00a0\u00a0The alga Chlorella vulgaris was maintained in the algal growth medium HB IV. The inhibition of algal growth was determined by measuring optical density\n at 680\u00a0nm (OD680). Initially, DM and two selected breakdown products were added to the algal cultures, and following degradation experiments\n analyses were carried out by high performance liquid chromatography. In addition, the possible relationship between DM degradation\n and toxicity was assessed, based on physico-chemical properties of the compounds and their toxicity.\n \n \n \n Results\u00a0\u00a0DM was rapidly absorbed onto the surface of the algal cells where it was hydrolyzed to diclofop (DC). Further degradation\n to 4-(2, 4-dichlorophenoxy) phenol (DP) occurred in the cells. However, only a minor amount of DC was degraded to DP under\n the same conditions when DC was initially added to the algal culture. When C. vulgaris was exposed to these compounds for 96\u00a0h, the determined EC50 showed that DC was about ten times less toxic than DM (EC50\u2009=\u20090.42\u00a0mg/L) and that DP (EC50\u2009=\u20090.20\u00a0mg/L) was the most toxic.\n \n \n \n Discussion\u00a0\u00a0Due to strong hydrophobicity and rare dissociation, DM has tendency toward absorption as compared to DC. The higher average\n degradation rates of DC initially treated by DM revealed the damage of the cell membranes caused by the DM and, thus, enhanced\n movement of DC into the cells. Following occurrence of phenolic breakdown products, DP suggested that DC should be intracellularly\n degraded to DP, which had a more potent mode of action and a higher acute toxicity. Moreover, the results for EC50 at various intervals were in accordance with degradation processes of the initial compounds, in which rapid formation of\n DP was attributed to an increasing toxicity of DM.\n \n \n \n Conclusions\u00a0\u00a0The toxicity of DM in algal suspensions increased with time due to its degradation to DP, which contributed significantly\n to the determined toxicity. These results indicate that the toxicity of the pesticide probably depends significantly on degradation.\n It is thus important to consider the time-dependent environmental processes when evaluating the toxicological effects of pesticides\n for proper risk assessment.\n \n \n \n Recommendations and perspectives\u00a0\u00a0Increasing transformation products of these contaminants are identified in the environment, although they seem to be unknown\n in terms of the lacking studies on environmental behavior and ecotoxicity concerning them. Certain breakdown products probably\n greatly contribute to the apparent toxicity of the parent compounds, which is ascribed to the parent compounds in general\n studies ignoring the dependence of their toxicity on various transformation pathways. These studies that identify new intermediates\n and assess their toxicity via the environmental processes will be helpful to distinguish the nature of toxicity of the parent\n contaminants.",
        "keywords": [
            "algae",
            "degradation",
            "diclofop-methyl (dm)",
            "toxicity",
            "acute toxicity",
            "optical density",
            "mode of action",
            "high performance liquid chromatography",
            "toxicity testing",
            "risk assessment"
        ],
        "authors": [
            {
                "name": "Xiyun Cai",
                "org": "Research Center of Environmental Science, College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, 310032 People\u2019s Republic of China"
            },
            {
                "name": "Jing Ye",
                "org": "Institute of Environmental Science, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310027 People\u2019s Republic of China"
            },
            {
                "name": "Guangyao Sheng",
                "org": "Research Center of Environmental Science, College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, 310032 People\u2019s Republic of China"
            },
            {
                "name": "Weiping Liu",
                "org": "Research Center of Environmental Science, College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, 310032 People\u2019s Republic of China"
            }
        ],
        "venue": "Environmental Science and Pollution Research",
        "year": 2009
    },
    "hEbPNR0R": {
        "id": "hEbPNR0R",
        "title": "Induction of estrogen-responsive gene transcription in the embryo, larval, juvenile and adult life stages of zebrafish as biomarkers of short-term exposure to endocrine disrupting chemicals.",
        "abstract": "Real-time quantitative RT-PCR was adopted to investigate the transcription of the estrogen-responsive genes in different developmental stages of zebrafish exposed to endocrine disrupting chemicals (EDCs). The lowest observed effect concentrations (LOECs) of 17beta-estradiol for inducing vtg1 transcription were 0.25, 0.5, 0.25 and <or=0.1 microg/L for embryo, larvae, juvenile and adult male zebrafish, respectively, while the LOECs of nonylphenol for induction of vtgs transcription were 50 microg/L in embryo and 100 microg/L in larvae and adult stages. The mRNA levels of the two vtgs were low in both the embryo and larvae stages, even at the highest 17beta-estradiol or nonylphenol exposure concentrations, while the mRNA levels in liver of adult zebrafish of the two vtgs were 10(2) or even 10(4) times higher than those of the control groups at the corresponding nonylphenol or 17beta-estradiol exposure concentrations. Similarity, the ERalpha and ERbeta mRNA levels in juvenile and adult zebrafish livers were also higher. Results suggest that in the early developmental stages of zebrafish might be more sensitive (low LOECs) to the presence of EDCs such as nonylphenol, but juvenile and adult zebrafish have a more effective (high induction levels). The use of zebrafish juveniles, larvae and embryos offers an alternative stage to detect EDCs.",
        "keywords": [
            "developmental stages",
            "endocrine disruption",
            "gene expression",
            "zebrafish",
            "embryos",
            "control group",
            "gene transcription"
        ],
        "authors": [
            {
                "name": "Yuanxiang Jin",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Rujia Chen",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Liwei Sun",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Haifeng Qian",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Weiping Liu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Zhengwei Fu",
                "org": ""
            }
        ],
        "venue": "Comparative biochemistry and physiology. Toxicology & pharmacology : CBP",
        "year": 2009
    },
    "3Mh381bu": {
        "id": "3Mh381bu",
        "title": "CHIRAL POLLUTANTS AND ENVIRONMETAL SAFETY",
        "abstract": "The significance of molecular chirality is widely recognized in life sciences.Because of the enantioselectivity in biologicalprocess,chiral pollutants have becomemore and more important.In this paper,the enantioselective of chiral pollutants in life,which have been reported in literatures were reviewed,and analyzed the enantiomer toxicity difference and principle.The development of chiral pollutants for the future studies was suggested.",
        "keywords": [
            "pesticide",
            "carcinogen",
            "endocrine disrupter.",
            "enantiomer"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": " Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou,,China; Institute of Environmental Science,Zhejiang University,Hangzhou,,China"
            },
            {
                "name": "XU Chao",
                "org": " Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou,,China"
            },
            {
                "name": "ZHOU Shan-shan",
                "org": " Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou,,China"
            }
        ],
        "venue": "Environmental Chemistry",
        "year": 2006
    },
    "DGPi11Ql": {
        "id": "DGPi11Ql",
        "title": "Hepatic and extrahepatic expression of estrogen-responsive genes in male adult zebrafish (Danio rerio) as biomarkers of short-term exposure to 17beta-estradiol.",
        "abstract": "Growing concern over reproductive hormones in the environment demands sensitive and efficient methods by use of molecular biomarkers to detect these contaminants in oviparous vertebrates. In this study, a real-time quantitative RT-PCR was adopted to investigate the expressions of three estrogen-responsive genes, Vtg I, Vtg II and ERalpha, in hepatic and extrahepatic tissues of male adult zebrafish exposed to varying concentrations of 17beta-estradiol (E2) for selected periods. Without exposure to E2, all the genes were expressed in the tissues of male controls with their levels being much lower than those in the respective tissues of female controls. The expressions of hepatic Vtg I and II mRNAs were induced significantly after 1-day exposure to E2 at as low as 0.25 microg L(-1). Significant induction in the expression of hepatic ERalpha mRNA required a higher E2 concentration (> or = 0.5 microg L(-1)) and a longer exposure (> or = 2 days), suggesting that Vtg I and Vtg II are more sensitive to E2 exposure. The induction of Vtg mRNA in the skin of zebrafish was also significant following a short exposure (1 day) to low E2 concentration (0.25 microg L(-1)), with the levels of Vtg I and Vtg II mRNA being increased by 25 and 5 times, respectively. These results suggest that Vtg I mRNA is a highly sensitive biomarker for determining the estrogenic effects of E2 and that the skin of zebrafish may be an appropriate substitute for liver for such a determination.",
        "keywords": [
            "zebrafish",
            "gene expression",
            "17\u03b2-estradiol",
            "estrogen receptor",
            "vitellogenin"
        ],
        "authors": [
            {
                "name": "Yuanxiang Jin",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Wanyuan Wang",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "G Daniel Sheng",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Zhengwei Fu",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            }
        ],
        "venue": "Environmental monitoring and assessment",
        "year": 2008
    },
    "FLYFu5be": {
        "id": "FLYFu5be",
        "title": "Modeling of Toxicity-Relevant Electrophilic Reactivity for Guanine with Epoxides: Estimating the Hard and Soft Acids and Bases (HSAB) Parameter as a Predictor.",
        "abstract": "According to the electrophilic theory in toxicology, many chemical carcinogens in the environment and/or their active metabolites are electrophiles that exert their effects by forming covalent bonds with nucleophilic DNA centers. The theory of hard and soft acids and bases (HSAB), which states that a toxic electrophile reacts preferentially with a biological macromolecule that has a similar hardness or softness, clarifies the underlying chemistry involved in this critical event. Epoxides are hard electrophiles that are produced endogenously by the enzymatic oxidation of parent chemicals (e.g., alkenes and PAHs). Epoxide ring opening proceeds through a SN2-type mechanism with hard nucleophile DNA sites as the major facilitators of toxic effects. Thus, the quantitative prediction of chemical reactivity would enable a predictive assessment of the molecular potential to exert electrophile-mediated toxicity. In this study, we calculated the activation energies for reactions between epoxides and the guanine N7 ...",
        "keywords": "",
        "authors": [
            {
                "name": "Jing Zhang",
                "org": ""
            },
            {
                "name": "Chenchen Wang",
                "org": ""
            },
            {
                "name": "Li Ji",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            }
        ],
        "venue": "Chemical Research in Toxicology",
        "year": 2016
    },
    "tiWlptIC": {
        "id": "tiWlptIC",
        "title": "Burned rice straw reduces the availability of clomazone to barnyardgrass.",
        "abstract": "Field burning of crop residue is a common post-harvest practice to dispose of these agricultural by-products and for land clearing. Burned crop residues may effectively adsorb pesticides and thus influence their bioavailability in agricultural soils. The adsorption of clomazone by a soil amended with a burned rice straw (BRS) was measured. The availability of clomazone to barnyardgrass in the soil in the absence and presence of BRS was tested. The BRS was 1000-20,000 times more effective than soil in sorbing clomazone. The sorption of clomazone by soil increased with increasing BRS amount in the soil. In a bioassay, the injury of barnyardgrass 9 days after planting decreased with increasing BRS amount in soil indicating the effect of BRS on clomazone availability. Residual analyses showed higher concentrations of clomazone in soils receiving higher rates of the herbicide than in soils with lower application rates suggesting the adsorptive role of BRS. At typical application rate of clomazone (0.3 microg g(-1)), BRS amounts of 0.02 wt.% and higher caused an appreciable reduction to a complete loss in clomazone availability. Calculations suggest that field burning of rice straw may result in sufficiently high amounts (>0.02 wt.%) of BRS, and hence contribute to often experienced loss of pesticide availability in agricultural soils. Our results may be extended to field situations where other crop residues and vegetation are burned. Alternative management of crop residues may improve the bioavailability of pesticides in agricultural soils.",
        "keywords": [
            "adsorption",
            "burning",
            "rice straw",
            "echinochloa crus-galli (l.) beauv.",
            "clomazone",
            "bioavailability",
            "greenhouse bioassay",
            "crop residue"
        ],
        "authors": [
            {
                "name": "Chao Xu",
                "org": "Institute of Environmental Science, Zhejiang University, Hangzhou 310029, China"
            },
            {
                "name": "Weiping Liu",
                "org": "Research Center of Environmental Science, College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "G Daniel Sheng",
                "org": ""
            }
        ],
        "venue": "The Science of the total environment",
        "year": 2008
    },
    "HTvCkMqi": {
        "id": "HTvCkMqi",
        "title": "Synchronous fluorescence measurement of enrofloxacin in the pharmaceutical formulation and its residue in milks based on the yttrium (III)-perturbed luminescence.",
        "abstract": "A simple, rapid and sensitive synchronous fluorescence method is put forward for the determination of enrofloxacin (ENRO) in the pharmaceutical formulation and its residue in milk based on the yttrium (III)-perturbed luminescence. When Y(3+) is added into the ENRO solution, the fluorescence of ENRO is significantly enhanced. The synchronous fluorescence technology is employed in the method to determine trace amount of ENRO residue in milks. The synchronous fluorescence intensity of the system is measured in a 1-cm quartz cell with excitation wavelength of 328 nm, \u0394\u03bb=80 nm. A good linear relationship between the fluorescence intensity and the ENRO concentration is obtained in the range of 1.0 \u00d7 10(-9) to 2.0 \u00d7 10(-6)mol L(-1) (r(2)=0.9992). The limit of detection (LOD) of this method attains as low as 3.0 \u00d7 10(-10) mol L(-1) (S/N=3). The selectivity of this method is also very good. Common metal ions, rare-earth ions and some pharmaceuticals, which are usually used together with ENRO, do not interfere with the determination of ENRO under the actual conditions. The proposed method can be applied to determine ENRO residue in milks, and limit of quantification (LOQ) determined in the spiked milk is estimated to be 2.8 \u00d7 10(-8) mol L(-1) (10 \u03bcg L(-1)). Moreover, this method can be used as a rapid screening for judging whether the ENRO residues in milks exceed Minimal Risk Levels (MRLs) or not. In addition, the mechanism of the fluorescence enhancement is also discussed in detail.",
        "keywords": [
            "residue",
            "fluoroquinolones",
            "milk",
            "enrofloxacin",
            "determination",
            "synchronous fluorescence",
            "pharmaceutical formulation",
            "limit of detection",
            "metal ion",
            "limit of quantification"
        ],
        "authors": [
            {
                "name": "Changlun Tong",
                "org": ""
            },
            {
                "name": "Xiajun Zhuo",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecological Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310029, PR China"
            },
            {
                "name": "Weiping Liu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecological Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310029, PR China"
            },
            {
                "name": "Jianmin Wu",
                "org": ""
            }
        ],
        "venue": "Talanta",
        "year": 2010
    },
    "jZHb9WiX": {
        "id": "jZHb9WiX",
        "title": "Simultaneous determination of four-components in mixed herbicides by modified target factor analysis-UV spectrophotometry]",
        "abstract": "In this paper, the modified target factor analysis-UV spectrophotometry method is established for simultaneous determination of paraquat CL, cyanzine, metolachlor and atrazine in mixed herbicides. The experimental results show that the recovery of each herbicide by MTFA is more accurate than by TFA. The recovery of paraquat CL ranges from 99.47% to 102.02%, of cyanzine 98.93%-102.75%, of metolachlor 98.13%-102.65% and of atrazine 97.42%-103.20%, with SD for the four components to be 1.16%, 1.84%, 1.84% and 2.55% respectively. All in all, the modified target factor analysis method can be used to determine accurately mixed herbicides which exhibits intrinsic interaction among components.",
        "keywords": [],
        "authors": [
            {
                "name": "Wei-ping Liu",
                "org": "Institute of Environment Science 3041, Zhejiang University, Hangzhou 310029, China."
            },
            {
                "name": "Xi-yun Cai",
                "org": ""
            },
            {
                "name": "Zhong-jian Xu",
                "org": ""
            },
            {
                "name": "Ke-bin Li",
                "org": ""
            },
            {
                "name": "Dong-mei Xu",
                "org": ""
            }
        ],
        "venue": "Guang pu xue yu guang pu fen xi = Guang pu",
        "year": 2004
    },
    "fS1mrK71": {
        "id": "fS1mrK71",
        "title": "Enantioselectivity in zebrafish embryo toxicity of the insecticide acetofenate.",
        "abstract": "Enantioselectivity in separation and toxicology of chiral xenobiotics have become one of the frontier topics interfacing chemistry and toxicology. In this study, enantiomers of insecticide acetofenate (AF) were separated on selected chiral columns by HPLC, and enantioselectivity in developmental toxicity was evaluated using the zebrafish embryo-larval assays. The AF enantiomers were baseline separated on Chiralcel OD, Chiralpak AD, and Sumichiral OA-2500I columns under optimized conditions. Pure enantiomers were obtained on Chiralcel OD. Optical rotatory dispersion (ORD) and circular dichroism (CD) detectors were used to determine the elution order and CD spectra of the enantiomers. The absolute configuration of enantiomers was identified as S-(+)-AF and R-(-)-AF by the octant rule from force-field calculations and CD spectra. The individual enantiomers were used in 4-day zebrafish embryo-larval bioassays, and a series of developmental end points were measured and compared. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to investigate the expressions of estrogen receptor alpha (ERalpha) in zebrafish embryo exposed to varying enantiomers. While the enantiomers showed no difference in acute toxicity, significant enantioselectivity was observed in developmental toxicities such as yolk sac edema and pericardial edema. The data of qRT-PCR showed that there was about 3.2-fold induction in the mRNA levels of ERalpha between fish exposed to (+)-AF and (-)-AF. The results suggest that enantioselectivity may occur at the developmental level even in the absence of selective acute toxicity and should be considered when evaluating ecotoxicological effects of chiral contaminants.",
        "keywords": [
            "embryos"
        ],
        "authors": [
            {
                "name": "Chao Xu",
                "org": ""
            },
            {
                "name": "Meirong Zhao",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Shengwen Chen",
                "org": ""
            },
            {
                "name": "Jiangying Gan",
                "org": ""
            }
        ],
        "venue": "Chemical research in toxicology",
        "year": 2008
    },
    "T5JPS9bn": {
        "id": "T5JPS9bn",
        "title": "Efficient removal of antibiotics in a fluidized bed reactor by facile fabricated magnetic powdered activated carbon.",
        "abstract": "Powdered activated carbons (PACs) with micrometer size are showing great potential for enabling and improving technologies in water treatment. The critical problem in achieving practical application of PAC involves simple, effective fabrication of magnetic PAC and the design of a feasible reactor that can remove pollutants and recover the adsorbent efficiently. Herein, we show that such materials can be fabricated by the combination of PAC and magnetic FeO with chitosan-Fe hydrogel through a simple co-precipitation method. According to the characterization results, CS-Fe/FeO/PAC with different micrometers in size exhibited excellent magnetic properties. The adsorption of tetracycline was fast and efficient, and 99.9% removal was achieved in 30\u00a0min. It also possesses good usability and stability to co-existing ions, organics, and different pH values due to its dispersive interaction nature. Finally, the prepared CS-Fe/FeO/PAC also performed well in the fluidized bed reactor with electromagnetic separation function. It could be easily separated by applying a magnetic field and was effectively in situ regenerated, indicating a potential of practical application for the removal of pollutants from water.",
        "keywords": [
            "Activated carbon",
            "Adsorption",
            "Antibiotics",
            "Magnetic separation"
        ],
        "authors": [
            {
                "name": "Jianqing Ma",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China."
            },
            {
                "name": "Qunfeng Yang",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China."
            },
            {
                "name": "Dongmei Xu",
                "org": "College of Biological and Environmental Engineering, Zhejiang Shuren University, Hangzhou, 310015, China."
            },
            {
                "name": "Xiaomei Zeng",
                "org": "College of Pharmaceutics and Material Engineering, Jinhua Polytechnic, Jinhua, 321007, China."
            },
            {
                "name": "Yuezhong Wen",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China. wenyuezhong@zju.edu.cn."
            },
            {
                "name": "Weiping Liu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China."
            }
        ],
        "venue": "Environmental science and pollution research international",
        "year": 2017
    },
    "xmP6niR8": {
        "id": "xmP6niR8",
        "title": "Enantioselectivity in aquatic toxicity of synthetic pyrethroid insecticide fenvalerate.",
        "abstract": "Synthetic pyrethroids (SPs) are a family of chiral insecticides with a large number of stereoisomers. Fenvalerate (FV) is one of the most potent pyrethroid insecticides, controlling a wide range of insect pests in agricultural fields, public health situations and animal houses. FV contains two chiral centers. In this study, four stereoisomers of FV were absolutely separated by high-performance liquid chromatography with a commercial chiral column, CHIRALCEL OJ-H, using n-hexane containing 1,2-dichloroethane and ethanol as mobile phase. Toxicity assays of each isomer and racemate of FV were performed using Daphnia magna (D. magna), zebrafish (Danio rerio) and zebrafish embryo-larval. In the acute toxicity of D. magna, significant differences were observed: the 24h EC(50) of alphaS-2S-FV was 51 times more toxic than the alphaR-2R-FV, and the 48 h LC(50) results showed that the alphaS-2S-FV was 99 times more toxic than alphaR-2R-FV. In the toxicity assay of D. rerio, dramatic differences were also found: the LC(50) value of alphaS-2S-FV was 17, 22, 39 and 56 times more toxic than the alphaR-2R-FV at 24, 48, 72 and 96 h, respectively. The assays of 4-day-old zebrafish embryo-larval showed that the exposure to FV enantioselectively induced crooked body, yolk sac edema and pericardial edema and that the alphaS-2S-FV was 3.8 times stronger than the other isomers in 96-h mortality. The results indicate that the enantiomeric differences should be taken into consideration in assessing the ecological effects of SPs.",
        "keywords": [
            "aquatic toxicity",
            "enantioselectivity",
            "fenvalerate",
            "synthetic pyrethroids",
            "aquatic animals",
            "enantiomers",
            "toxicity",
            "public health",
            "high performance liquid chromatography",
            "embryos",
            "acute toxicity"
        ],
        "authors": [
            {
                "name": "Yun Ma",
                "org": "Research Center of Environmental Science, Zhejiang University of Technology, Hangzhou 310032, People's Republic of China"
            },
            {
                "name": "Linhua Chen",
                "org": "Research Center of Environmental Science, Zhejiang University of Technology, Hangzhou 310032, People's Republic of China"
            },
            {
                "name": "Xianting Lu",
                "org": "Institute of Environmental Science and Engineering, Hangzhou Dianzi University, Hangzhou 310018, People's Republic of China"
            },
            {
                "name": "Huadong Chu",
                "org": "Research Center of Environmental Science, Zhejiang University of Technology, Hangzhou 310032, People's Republic of China"
            },
            {
                "name": "Chao Xu",
                "org": "Research Center of Environmental Science, Zhejiang University of Technology, Hangzhou 310032, People's Republic of China"
            },
            {
                "name": "Weiping Liu",
                "org": ""
            }
        ],
        "venue": "Ecotoxicology and environmental safety",
        "year": 2009
    },
    "JpQvQiI6": {
        "id": "JpQvQiI6",
        "title": "Early life exposure of zebrafish (<Emphasis Type=\"Italic\">Danio rerio</Emphasis>) to synthetic pyrethroids and their metabolites: a comparison of phenotypic and behavioral indicators and gene expression involved in the HPT axis and innate immune system",
        "abstract": "Ecotoxicological studies have revealed the association between synthetic pyrethroid (SP) exposure and aquatic toxicity in fish; however, research on the toxic effects of SP metabolites is still limited. In this study, the toxicity of two SPs (permethrin (PM) and \u03b2-cypermethrin (\u03b2-CP)) and their three metabolites (3-phenoxybenzoic alcohol (PBCOH), 3-phenoxybenzaldehyde (PBCHO), and 3-phenoxybenzoic acid (PBCOOH)) towards zebrafish embryos and larvae was evaluated. Both SPs and their metabolites exhibited significant developmental toxicities, caused abnormal vascular development, and changed locomotor activities in larvae. The alteration of gene expression involved in the thyroid system and the innate immune system indicated that SPs and their three metabolites have the potency to induce thyroid disruption and trigger an immune response. The results from the present study suggest that SP metabolites could induce multiple toxic responses similar to parent compounds, and their toxicity should be considered for improving the understanding of environmental risks of SPs.",
        "keywords": [
            "Pyrethroids",
            " Metabolites",
            " Zebrafish",
            " Locomotor activity",
            " Thyroid disrupter",
            " Innate immune"
        ],
        "authors": [
            {
                "name": "Chao\u00a0Xu",
                "org": "Research Center of Environmental Science, College of Environment,Zhejiang University of Technology,Hangzhou,China"
            },
            {
                "name": "Xinfang\u00a0Li",
                "org": "Research Center of Environmental Science, College of Environment,Zhejiang University of Technology,Hangzhou,China"
            },
            {
                "name": "Meiqing\u00a0Jin",
                "org": "Research Center of Environmental Science, College of Environment,Zhejiang University of Technology,Hangzhou,China"
            },
            {
                "name": "Xiaohui\u00a0Sun",
                "org": "Zhejiang Environmental Monitoring Centre,Hangzhou,China"
            },
            {
                "name": "Lili\u00a0Niu",
                "org": "Research Center of Environmental Science, College of Environment,Zhejiang University of Technology,Hangzhou,China"
            },
            {
                "name": "Chunmian\u00a0Lin",
                "org": "Research Center of Environmental Science, College of Environment,Zhejiang University of Technology,Hangzhou,China"
            },
            {
                "name": "Weiping\u00a0Liu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences,Zhejiang University,Hangzhou,China"
            }
        ],
        "venue": "Environmental science and pollution research international",
        "year": 2018
    },
    "HIG26M5a": {
        "id": "HIG26M5a",
        "title": "Visible Light-Induced Degradation of Phenol over Iodine-Doped Titanium Dioxide Modified with Platinum: Role of Platinum and the Reaction Mechanism",
        "abstract": "",
        "keywords": [
            "visible light",
            "reaction mechanism"
        ],
        "authors": [
            {
                "name": "Zhiqiao He",
                "org": ""
            },
            {
                "name": "Lei Xie",
                "org": ""
            },
            {
                "name": "Jinjun Tu",
                "org": ""
            },
            {
                "name": "Shuang Song",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Zhiwu Liu",
                "org": ""
            },
            {
                "name": "Jiaqi Fan",
                "org": ""
            },
            {
                "name": "Qi Liu",
                "org": ""
            },
            {
                "name": "Jianmeng Chen",
                "org": ""
            }
        ],
        "venue": "Journal of Physical Chemistry C",
        "year": 2010
    },
    "JkhVjjai": {
        "id": "JkhVjjai",
        "title": "Molecular interactions of benzophenone UV filters with human serum albumin revealed by spectroscopic techniques and molecular modeling.",
        "abstract": "Benzophenone (BP)-type UV filters have been widely used in many personal care products to protect human from UV exposure. Their dermal applications can cause direct human health risk following accumulation in bloodstream. Few studies have addressed whether BP-type UV filters could bind and alter the structure and function of human serum albumin (HSA), the major carrier protein in plasma. Four benzophenones, BP-1, BP-2, BP-3 and BP-8 were selected to investigate their potentially toxic interactions with HSA and the intrinsic binding mechanism using combined spectroscopies and molecular docking techniques. Four benzophenones significantly quench the intrinsic fluorescence of HSA via static mode. The competitive binding fluorescence assay and molecular docking both revealed that the benzophenones bind at site II of HSA. Their binding constants range from 1.91 \u00d7 10(4)M(-1) to 12.96 \u00d7 10(4)M(-1) at 296 K. BP-8 interacts with HSA mainly through hydrogen bonding interactions and van der Waals interactions, while hydrophobic interactions and electrostatic interactions are dominant for interactions between BP-1, BP-2, BP-3 and HSA. Molecular docking revealed that the changes in structural moiety and hydrophobicity of four benzophenones account for their different binding affinities. As further revealed by circular dichroism and time-resolved fluorescence decay, these benzophenones cause global and local structural changes of HSA, which illustrates their potential toxicity to cause structural damage of HSA. Two degradation products of BP-3 have higher binding affinities to HSA, suggesting higher potencies in causing adverse effects on human health.",
        "keywords": [
            "fluorescence lifetime",
            "uv filters",
            "molecular docking spectroscopy",
            "human serum albumin",
            "benzophenones"
        ],
        "authors": [
            {
                "name": "Feng Zhang",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Jing Zhang",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Changlun Tong",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Yadong Chen",
                "org": "China Pharmaceutical University(China Pharmaceutical University),Nanjing,China"
            },
            {
                "name": "Shulin Zhuang",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Journal of hazardous materials",
        "year": 2013
    },
    "FC76R9dj": {
        "id": "FC76R9dj",
        "title": "Factors influencing the ecological and human health risks of DDTs in soils and air at the isomeric and enantiomeric levels.",
        "abstract": "Even though the application of dichlorodiphenyltrichloroethanes (DDTs) has been restricted for over 30 years, their ubiquitous existence still poses profound adverse impacts on ecosystem and human health. In this study, simultaneous soil and air sampling campaigns at different functional areas were conducted in warm and cold seasons. Based on the residue levels and enantiomeric signatures of DDT and its metabolites in soils and air, the parameters influencing ecological and human health risks were explored. \u03a3DDT concentrations in soils correlated positively with organic matter (OM) and negatively with pH, whereas atmospheric DDT levels were primarily facilitated by increased temperature. High temperature and low soil pH were also favorable for the transformation of DDT into its metabolites. The inhabitants living in agricultural regions or in areas with higher soil OM or pH\u202f<\u202f7 were exposed to higher existing and potential health risks of soil DDTs. In addition, at lower temperatures, the existing and potential carcinogenic risks of DDTs from soil exposure were higher, whereas risks from air inhalation were lower. Health risks would be increased when considering the enantioselective toxicity of o,p'-DDT and o,p'-DDD. The results from this study could provide baseline support for risk control and avoidance of DDTs.",
        "keywords": [
            "Air-soil exchange",
            "DDT",
            "Enantioselectivity",
            "Health risk",
            "Transformation"
        ],
        "authors": [
            {
                "name": "Lili Niu",
                "org": "College of Life and Environmental Sciences, Hangzhou Normal University, 310036, China; International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: llniu@hznu.edu.cn."
            },
            {
                "name": "Chao Xu",
                "org": "College of Environment, Zhejiang University of Technology, Hangzhou 310014, China."
            },
            {
                "name": "Siyu Zhu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Hangjun Zhang",
                "org": "College of Life and Environmental Sciences, Hangzhou Normal University, 310036, China."
            },
            {
                "name": "Weiping Liu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: wliu@zju.edu.cn."
            }
        ],
        "venue": "Journal of hazardous materials",
        "year": 2018
    },
    "pF80KJew": {
        "id": "pF80KJew",
        "title": "Study on supramolecular complexes of cyclodextrins and fenoxaprop-p-ethyl by UV spectra]",
        "abstract": "The supramolecular complexes of fenoxaprop-p-ethyl and various cyclodextrins (beta-CD, HP-beta-CD, RAMEB) were studied by UV spectra technique. The results showed that all cyclodextrins could form 1:1 inclusion complexes with fenoxaprop-p-ethyl in ethanol-water (the volume ratio of ethanol to water was 1 : 4), and the binding constants of the three types of cyclodextrins toward fenoxaprop-p-ethyl were in the order of KRAEB>KHP-beta-CD>Kbeta-CD. Between 298. 15 and 318. 15 K, the binding constants decreased with temperature increasing. The Gibbs free energy deltaG, enthalpy change deltaH, and entropy change deltaS determined were all negative, suggesting that the inclusion complexation is exothermic and can spontaneously occur by the balance of enthalpy driving and entropy opposing.",
        "keywords": [
            "supramolecular complexes",
            "uv spectra",
            "cyclodextrins",
            "fenoxaprop-p-ethyl"
        ],
        "authors": [
            {
                "name": "An-ping Zhang",
                "org": "Institute of Environmental Science,Zhejiang University,Hangzhou ,China"
            },
            {
                "name": "Fan Luo",
                "org": "Institute of Environmental Science,Zhejiang University,Hangzhou ,China"
            },
            {
                "name": "Wei-ping Liu",
                "org": "Research Center of Green Chirality,College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou ,China;)"
            }
        ],
        "venue": "Guang pu xue yu guang pu fen xi = Guang pu",
        "year": 2006
    },
    "brvCbgeF": {
        "id": "brvCbgeF",
        "title": "Study on the reaction mechanism of chloroacetanilide herbicides with urease using fluorescence spectrum and high-performance liquid chromatography]",
        "abstract": "The relationship between excess thermodynamic function and binding to urease of four chloroacetanilide herbicides was studied using high-performance liquid chromatography and fluorescence spectrum. The linear relationship between the composition of mobile phase of RP-HPLC and the capacity factor of chloroacetanilide herbicides has been obtained. The excess thermodynamic enthalpy (deltaH* ) of acetochlor, pretilachlor, butachlor and metolachlor was determined, and the binding constant K and the number of binding sites with urease were calculated. The relationship between excess thermodynamic function and the binding constant K was suggested.",
        "keywords": [
            "excess thermodynamic function",
            "chloroacetanilide herbicides",
            "urease",
            "binding constant"
        ],
        "authors": [
            {
                "name": "Hui-jun Liu",
                "org": "Institute of Environmental Science, Zhejiang University, Hangzhou 310027, China."
            },
            {
                "name": "Xiu-Ming Zhan",
                "org": ""
            },
            {
                "name": "Ke-bin Li",
                "org": ""
            },
            {
                "name": "Wei-ping Liu",
                "org": ""
            }
        ],
        "venue": "Guang pu xue yu guang pu fen xi = Guang pu",
        "year": 2005
    },
    "v8IJDSfB": {
        "id": "v8IJDSfB",
        "title": "Enantioselective separation and degradation of the herbicide dichlorprop methyl in sediment.",
        "abstract": "Chiral pesticides currently constitute about 50% of all pesticides dosage used in China, and this ratio is increasing as more complex structures are introduced. Dichlorprop methyl (DCPPM) is a chiral herbicide consisting of a pair of enantiomers. In this study, the enantiomeric separation of DCPPM was investigated by gas chromatography (GC) and high-performance liquid chromatography (HPLC) using chiral stationary phases (CSPs), and its enantiomeric degradation was characterized using a DCPPM-degrading bacterial strain isolated from an activated sludge from a textile-printing wastewater treatment plant. Baseline separation by both GC and HPLC was achieved. Incubation with DCPPM-degrading bacteria in different pH solutions showed that the R enantiomer was preferentially degraded over the S enantiomer of DCPPM. The degradation rate constant decreased with increasing pH in the order of k(pH5) approximately k(pH7) >k(pH9). In comparison, the enantioselectivity as indicated by EF followed the order of pH 7 > pH 9-pH 5.",
        "keywords": [
            "chiral",
            "dichlorprop methyl",
            "enantioselective biodegradation",
            "enantioselective separation"
        ],
        "authors": [
            {
                "name": "Yun Ma",
                "org": ""
            },
            {
                "name": "Chao Xu",
                "org": ""
            },
            {
                "name": "Yuezhong Wen",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            }
        ],
        "venue": "Chirality",
        "year": 2009
    },
    "I1hIJGhn": {
        "id": "I1hIJGhn",
        "title": "Long-term exposure to the non-steroidal anti-inflammatory drug (NSAID) naproxen causes thyroid disruption in zebrafish at environmentally relevant concentrations.",
        "abstract": "The presence of trace levels of pharmaceuticals is an emerging issue impacting the aquatic ecosystem. Naproxen (NPX) is a nonsteroidal anti-inflammatory drug (NSAID) that has been frequently detected in aquatic environments worldwide. Recently, concerns regarding endocrine disruption by NSAIDs have increased; however, their effects on the thyroid system have yet to be understood. In this study, zebrafish were utilized to evaluate the thyroid-disrupting effects of NPX. After a 60-day exposure to various concentrations of NPX (0.1, 1, 10 and 100\u202f\u03bcg/L), the body length and weight of the zebrafish were significantly decreased. The decrease of cytochrome P450 gene expression and enzyme activity might inhibit the metabolism of NPX, which might result in the significant bioconcentration in zebrafish. Thyroid hormone (TH) analysis showed that both triiodothyronine (T3) and thyroxine (T4) levels were substantially decreased. Gene transcription expressions along the hypothalamic-pituitary-thyroid (HPT) axis were also markedly affected. Significant downregulation of dio1, dio2, nis, nkx2.1, pax8, tg, tpo, tr\u03b2 and ttr levels, along with the stimulation of the tsh\u03b2 gene, were also observed in exposed fish compared to controls. Western blot analysis indicated that expression of the TTR protein was significantly decreased, which coincides with the results of the gene expression analysis. Collectively, our observations show that NPX increases the risk of bioconcentration and thyroid disruption in zebrafish. Given the continued increasing consumption and emission of pharmaceuticals, thyroid disruption should be considered when assessing the aquatic risk of long-term exposure to environmentally relevant concentrations of pharmaceuticals.",
        "keywords": [
            "Bioconcentration",
            "NSAIDs",
            "Naproxen",
            "Thyroid disruption",
            "Zebrafish"
        ],
        "authors": [
            {
                "name": "Chao Xu",
                "org": "College of Environment, Zhejiang University of Technology, Hangzhou 310032, China."
            },
            {
                "name": "Lili Niu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Hangqin Guo",
                "org": "College of Environment, Zhejiang University of Technology, Hangzhou 310032, China."
            },
            {
                "name": "Xiaohui Sun",
                "org": "Zhejiang Environmental Monitoring Center, Hangzhou 310012, China."
            },
            {
                "name": "Lihui Chen",
                "org": "Hydrology Bureau of Zhejiang Province, Hangzhou 310000, China."
            },
            {
                "name": "Wenqing Tu",
                "org": "College of Environment, Zhejiang University of Technology, Hangzhou 310032, China."
            },
            {
                "name": "Qizhou Dai",
                "org": "College of Environment, Zhejiang University of Technology, Hangzhou 310032, China."
            },
            {
                "name": "Jing Ye",
                "org": "School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China."
            },
            {
                "name": "Weiping Liu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Jinsong Liu",
                "org": "Zhejiang Environmental Monitoring Center, Hangzhou 310012, China; College of Environment, Zhejiang University of Technology, Hangzhou 310032, China. Electronic address: liu70923@163.com."
            }
        ],
        "venue": "The Science of the total environment",
        "year": 2019
    },
    "1B7H0Ryv": {
        "id": "1B7H0Ryv",
        "title": "Elucidation of the enantioselective enzymatic hydrolysis of chiral herbicide dichlorprop methyl by chemical modification.",
        "abstract": "Up to 25% of the current pesticides are chiral, the molecules have chiral centers, but most of them are used as racemates. In most cases, enantiomers of chiral pesticides have different fates in the environment. Knowledge of the function of amino acids of enzymes involved in enantioselective behaviors contributes to the understanding of the enantioselectivity of chiral pesticides. In this work, Aspergillus niger lipase (ANL, EC3.1.1.3) was chemically modified using bromoacetic acid (BrAc), 2,3-butanedione (BD), N-bromosuccinimide (NBS), and methanal. The enantioselectivity of the enzymatic hydrolysis of 2,4-dichlorprop-methyl (DCPPM) was investigated by chiral GC. The results have suggested that histidine, arginine, and tryptophan are essential for lipase activity and might be involved in the catalytic site of ANL. In addition, histidine and lysine play an important role in determining the observed enantioselective hydrolysis of chiral herbicide dichlorprop methyl. The molecular modeling study revealed that the essential hydrogen bonds formed between DCPPM and catalytic residues of ANL might be responsible for the enantioselectivity of DCPPM. The loss of enantioselectivity can also arise from the fact that the modification of the amino acids may cause changes in both the nature of the ANL enzyme conformation and the binding pattern of DCPPM. Our study provides basic information for the exploration of the enantioselective interaction mechanism of enzymes with chiral pesticides.",
        "keywords": [
            "lipase",
            "pesticide",
            "chemical modification",
            "hydrolysis",
            "enantioselectivity"
        ],
        "authors": [
            {
                "name": "Yuezhong Wen",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Chandan Li",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Zhaohua Fang",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Shulin Zhuang",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Journal of agricultural and food chemistry",
        "year": 2011
    },
    "UDsFhHGa": {
        "id": "UDsFhHGa",
        "title": "Research Advances in Toxicological Effects of External Pollutants on Earthworms",
        "abstract": "The earthworm is considered as a suitable biomonitor animal to determine the ecological hazard of polluted soil.When exposed to pollutants,earthworms can be changed obviously on the level of molecular,cell and physiology.That may affect the survival,growth and reproductive capacity of earthworms,and change population finally.Based on the summary of previous studies,the toxicological effects of heavy metal,pesticide,veterinary drugs and additives on earthworms were reviewed from microcosmic,individual and ecological levels,and the future research directions were discussed.",
        "keywords": [
            "earthworm",
            "toxicity",
            "pollutant"
        ],
        "authors": [
            {
                "name": "XU Dong-mei",
                "org": "College of Biology and Environmental Engineering,Zhejiang Shu-ren University,Hangzhou  2.Environment Monitoring Station of Shanxi Province,Taiyuan "
            },
            {
                "name": "LIU Wei-ping",
                "org": "Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou "
            }
        ],
        "venue": "Asian Journal of Ecotoxicology",
        "year": 2009
    },
    "sztTifKJ": {
        "id": "sztTifKJ",
        "title": "Study on the determination of ciprofloxacin by the terbium (III) ion fluorescence probe sensitized by the surfactant",
        "abstract": "The experiments indicated that terbium(III) ion could complex ciprofloxacin, then emitted the characteristic fluorescence of terbium(III) ion. When the surfactant of SDBS was added, the fluorescence intensity of the system was greatly increased. From this, a sensitive method of determining the ciprofloxacin was developted. The fluorescence intensity was determined by a 1 cm quartz cell with the excitation wavelength of 300 nm and the emission wavelength of 545 nm. The optimal conditions are as follows: pH 8.0-8.5, the concentration of terbium(III) is 5.0 x 10(-5) mol x L(-1), the surfactant concentration of SDBS is 8.0 x 10(-4) mol x L(-1). The linear range is 2.5 x 10(-6) mol x L(-1) -2.0 x 10(-8) mol x L(-1), and the detection limit (S/N = 3) is 4.0 x 10(-9) mol x L(-1). The presented method was applied to determine the real pharmaceuticals of ciprofloxacin.",
        "keywords": [
            "Ciprofloxacin",
            "Determination",
            "Fluorescence probe",
            "Terbium"
        ],
        "authors": [
            {
                "name": "Shang lun Tong",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Guang-Hong Xiang",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Wei-Ping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis",
        "year": 2005
    },
    "jVrhMrEX": {
        "id": "jVrhMrEX",
        "title": "A novel (S)-6-hydroxynicotine oxidase gene from Shinella sp. strain HZN7.",
        "abstract": "Nicotine is an important environmental toxicant in tobacco waste. Shinella sp. strain HZN7 can metabolize nicotine into nontoxic compounds via variations of the pyridine and pyrrolidine pathways. However, the catabolic mechanism of this variant pathway at the gene or enzyme level is still unknown. In this study, two 6-hydroxynicotine degradation-deficient mutants, N7-M9 and N7-W3, were generated by transposon mutagenesis. The corresponding mutant genes, designated nctB and tnp2, were cloned and analyzed. The nctB gene encodes a novel flavin adenine dinucleotide-containing (S)-6-hydroxynicotine oxidase that converts (S)-6-hydroxynicotine into 6-hydroxy-N-methylmyosmine and then spontaneously hydrolyzes into 6-hydroxypseudooxynicotine. The deletion and complementation of the nctB gene showed that this enzyme is essential for nicotine or (S)-6-hydroxynicotine degradation. Purified NctB could also convert (S)-nicotine into N-methylmyosmine, which spontaneously hydrolyzed into pseudooxynicotine. The kinetic constants of NctB toward (S)-6-hydroxynicotine (Km = 0.019 mM, kcat = 7.3 s(-1)) and nicotine (Km = 2.03 mM, kcat = 0.396 s(-1)) indicated that (S)-6-hydroxynicotine is the preferred substrate in vivo. NctB showed no activities toward the R enantiomer of nicotine or 6-hydroxynicotine. Strain HZN7 could degrade (R)-nicotine into (R)-6-hydroxynicotine without any further degradation. The tnp2 gene from mutant N7-W3 encodes a putative transposase, and its deletion did not abolish the nicotine degradation activity. This study advances the understanding of the microbial diversity of nicotine biodegradation.",
        "keywords": [],
        "authors": [
            {
                "name": "Jiguo Qiu",
                "org": "Key Laboratory of Environmental Remediation and Ecosystem Health, Ministry of Education, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China."
            },
            {
                "name": "Yin Wei",
                "org": "Research Center of Environmental Science, College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, China."
            },
            {
                "name": "Yun Ma",
                "org": "Research Center of Environmental Science, College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, China."
            },
            {
                "name": "Rongti Wen",
                "org": "Research Center of Environmental Science, College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, China."
            },
            {
                "name": "Yuezhong Wen",
                "org": "Key Laboratory of Environmental Remediation and Ecosystem Health, Ministry of Education, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China."
            },
            {
                "name": "Weiping Liu",
                "org": "Key Laboratory of Environmental Remediation and Ecosystem Health, Ministry of Education, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China wliu@zju.edu.cn."
            }
        ],
        "venue": "Applied and environmental microbiology",
        "year": 2014
    },
    "DrwCMJFC": {
        "id": "DrwCMJFC",
        "title": "Pyrethroid Pesticide Exposure and Risk of Primary Ovarian Insufficiency in Chinese Women.",
        "abstract": "Pyrethroids are a class of widely used insecticides. Female animal studies suggested that pyrethroid exposure impaired ovarian function, which resulted in similar symptoms of primary ovarian insufficiency (POI). However, it is still unknown whether this association applies to women. In this case-control study, a total of 172 POI patients and 247 control women were recruited in Zhejiang, China. The urinary concentrations of metabolites of pyrethroids, 3-phenoxybenzoic acid (3-PBA) and 4-fluoro-3-phenoxybenzoic acid (4-F-3-PBA), as well as the serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and anti-Mullerian hormone (AMH) were determined. The associations of pyrethroid metabolites with POI and POI-related hormones were accessed using unconditional logistic regression. Higher urinary levels of 3-PBA were significantly associated with increased risk of POI [adjusted odds ratio (OR) =2.344, 95% CI: 1.193-4.607 for the highest vs. lowest quartile of 3-PBA, p=0.013]. Stratified analyses showed that each log increase in urinary 3-PBA concentration was significantly associated with an 51.0% induction in odds of being in the highest quartile of FSH and 28.6% being in the highest quartile of LH levels, while a 25.9 % reduction in odds of being in the highest quartile of AMH levels (All p for trend <0.05). To our knowledge, this is the first case-control study to report an association of pyrethroid exposure with increased risk of POI in women.",
        "keywords": "",
        "authors": [
            {
                "name": "Chunming Li",
                "org": "Women\u2019s#R#Reproductive Health Key Laboratory of Zhejiang Province, Women\u2019s#R#Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"
            },
            {
                "name": "Miaofeng Cao",
                "org": "MOE#R#Key Laboratory of Environmental Remediation and Ecosystem Health,#R#College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China"
            },
            {
                "name": "Linjuan Ma",
                "org": "Women\u2019s#R#Reproductive Health Key Laboratory of Zhejiang Province, Women\u2019s#R#Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"
            },
            {
                "name": "Xiaoqing Ye",
                "org": "MOE#R#Key Laboratory of Environmental Remediation and Ecosystem Health,#R#College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China"
            },
            {
                "name": "Yang Song",
                "org": "Women\u2019s#R#Reproductive Health Key Laboratory of Zhejiang Province, Women\u2019s#R#Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"
            },
            {
                "name": "Wuye Pan",
                "org": "MOE#R#Key Laboratory of Environmental Remediation and Ecosystem Health,#R#College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China"
            },
            {
                "name": "Zhengfen Xu",
                "org": "Women\u2019s#R#Reproductive Health Key Laboratory of Zhejiang Province, Women\u2019s#R#Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"
            },
            {
                "name": "Xiaochen Ma",
                "org": "MOE#R#Key Laboratory of Environmental Remediation and Ecosystem Health,#R#College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China"
            },
            {
                "name": "Yibing Lan",
                "org": "Women\u2019s#R#Reproductive Health Key Laboratory of Zhejiang Province, Women\u2019s#R#Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"
            },
            {
                "name": "Peiqiong Chen",
                "org": "Women\u2019s#R#Reproductive Health Key Laboratory of Zhejiang Province, Women\u2019s#R#Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"
            },
            {
                "name": "Weiping Liu",
                "org": "MOE#R#Key Laboratory of Environmental Remediation and Ecosystem Health,#R#College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China"
            },
            {
                "name": "Jing Liu",
                "org": "MOE#R#Key Laboratory of Environmental Remediation and Ecosystem Health,#R#College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China"
            },
            {
                "name": "Jianhong Zhou",
                "org": "Women\u2019s#R#Reproductive Health Key Laboratory of Zhejiang Province, Women\u2019s#R#Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"
            }
        ],
        "venue": "Environmental science & technology",
        "year": 2018
    },
    "zxcvOby1": {
        "id": "zxcvOby1",
        "title": "Studies on the effect of fluorine pollution on the stability of soil colloid.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Liu Weiping",
                "org": "Environmental Science Institute of Zhejiang University, Hangzhou 310029, China)"
            }
        ],
        "venue": "China Environmental Science",
        "year": 2002
    },
    "dkl3d9vi": {
        "id": "dkl3d9vi",
        "title": "Preparation, stabilization, and bioefficacy of beta-cyclodextrin inclusion compounds of chloramidophos.",
        "abstract": "Cyclodextrins are common compounds capable of forming inclusion complexes with a variety of pesticides to improve their solubility, bioavailability, and stability. In this study, chloramidophos (CP) was inclusion-complexed with beta-cyclodextrin (beta-CD) by a kneading method in an attempt to gain a more stable but equally effecacious formulation compared with CP alone. A 1:1 CP-beta-CD complex with an inclusion constant of 203.0 M(-1) was determined to exist by UV spectrophotometry. The structural identification, thermal stability, and biological assays of the CP-beta-CD complex were then carried out with a product with the maximum guest loading efficiency. The data measured by differential scanning calorimetry (DSC), Fourier transform infrared (FT-IR), and X-ray diffraction (XRD), where the endothermic peaks of beta-CD, the FT-IR bands, and the XRD peaks were generally changed, deduced the formation of complex. Results of the thermal stability assay showed that the degradation rate of CP in 14-day incubation was slowed by a factor of 3.6 when it was complexed with beta-CD. Then, activity and toxicity of CP influenced by the encapsulated process of beta-CD were evaluated by an in vitro acetylcholinesterase (AChE) inhibition assay and an acute aquatic toxicity assay, respectively. No significant differences were found in both the two biological assays by a t-test. This indicated that the encapsulation process greatly improved the thermal stability of the pesticide with no adverse effects on bioefficacy compared to that of CP. There is a promising outlook for CP-beta-CD to be produced as the active ingredient of various formulation additives of CP for its continued application.",
        "keywords": [],
        "authors": [
            {
                "name": "Shanshan Zhou",
                "org": "Institute of Environmental Science, Zhejiang University, Hangzhou 310027, People's Republic of China."
            },
            {
                "name": "Lumei Wang",
                "org": ""
            },
            {
                "name": "Anping Zhang",
                "org": ""
            },
            {
                "name": "Kunde Lin",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            }
        ],
        "venue": "Journal of agricultural and food chemistry",
        "year": 2008
    },
    "goRf8X02": {
        "id": "goRf8X02",
        "title": "Hair as an alternative matrix to monitor human exposure to plasticizers - Development of a liquid chromatography - tandem mass spectrometry method.",
        "abstract": "The application and production of alternative plasticizers (APs) has been increasing in the last decade in replacement of conventional phthalates due to their toxicity. This calls for the development of non-invasive monitoring approaches to assess human exposure to APs. A method for the simultaneous measurement of exposure biomarkers of di(2\u2011propylheptyl) phthalate (DPHP), di(isononyl)cyclohexane\u20111,2\u2011dicarboxylate (DINCH), di(2\u2011ethylhexyl) terephthalate (DEHTP) and di\u20112\u2011ethylhexyl adipate (DEHA) in hair samples was developed and validated in this study. Prior to the analysis, the hair samples were washed in acetone and ultrapure water and pulverized to powder. Further, a solid-liquid and solid-phase extraction, followed by quantification using liquid chromatography - tandem mass spectrometry (LC-MS/MS) was performed. The method was validated in terms of recovery, matrix effects, carry-over, linearity, limits of quantification, within- and between-run precision and trueness. Satisfying results were obtained for all targeted compounds, except for mono(2\u2011ethylhexyl) adipate (MEHA), which was monitored only qualitatively. The optimized method was implemented in a pilot biomonitoring study with hair samples from 9 healthy volunteers. Detection frequencies of seven metabolites ranged from 11% to 100%. Mono(2\u2011ethylhexyl) terephthalate (MEHTP) and mono(2\u2011ethyl\u20115\u2011oxohexyl) adipate (oxo-MEHA) were found in all hair samples. More hydrophobic monoester metabolites were found to be incorporated in hair to a greater extent compared to their oxidized counterparts. Obtained results show that the developed method can detect AP metabolites in hair, supporting the use of this alternative matrix in human biomonitoring.",
        "keywords": [
            "Alternative biomatrix",
            "Alternative plasticizers",
            "Hair",
            "Human biomonitoring",
            "LC\u2013MS/MS",
            "Metabolites"
        ],
        "authors": [
            {
                "name": "Shanshan Yin",
                "org": "Institution of Environmental Health, Zhejiang University, 310058 Hangzhou, Zhejiang, China; Toxicological Centre, Department of Pharmaceutical Sciences, University of Antwerp, 2610 Wilrijk, Belgium."
            },
            {
                "name": "Frederic Been",
                "org": "Toxicological Centre, Department of Pharmaceutical Sciences, University of Antwerp, 2610 Wilrijk, Belgium."
            },
            {
                "name": "Weiping Liu",
                "org": "Institution of Environmental Health, Zhejiang University, 310058 Hangzhou, Zhejiang, China."
            },
            {
                "name": "Adrian Covaci",
                "org": "Toxicological Centre, Department of Pharmaceutical Sciences, University of Antwerp, 2610 Wilrijk, Belgium. Electronic address: adrian.covaci@uantwerpen.be."
            }
        ],
        "venue": "Journal of chromatography. B, Analytical technologies in the biomedical and life sciences",
        "year": 2018
    },
    "Oppo7xEj": {
        "id": "Oppo7xEj",
        "title": "Experimental Research and Application of Zebrafish and Embryos in Toxicology",
        "abstract": "Zebrafish has the inherent advantage compared with other model animals, and its use in scientific research is growing rapidly. In this review, we introduced the zebrafish genome, including forward genetic, reverse genetic and the application of zebrafish in drug discovery and human disease research; we also summarized the application of zebrafish in developmental biology. Finally, we reviewed the use of zebrafish in various toxicology research fields(acute toxicity, endocrine disruption, developmental toxicity, neurotoxicity, vascular research and cancer research).",
        "keywords": [
            "transgene",
            "cell",
            "mutation",
            "toxicology",
            "genome"
        ],
        "authors": [
            {
                "name": "WANG Jia-jia",
                "org": " Research Center of Environmental Science, Zhejiang University of Technology, Hangzhou "
            },
            {
                "name": "XU Chao",
                "org": " Institute of Environmental Science, Zhejiang University, Hangzhou "
            },
            {
                "name": "TU Yun-jie",
                "org": " Research Center of Environmental Science, Zhejiang University of Technology, Hangzhou "
            },
            {
                "name": "FU Zheng-wei",
                "org": " Research Center of Environmental Science, Zhejiang University of Technology, Hangzhou "
            },
            {
                "name": "LIU Wei-ping",
                "org": " Research Center of Environmental Science, Zhejiang University of Technology, Hangzhou "
            }
        ],
        "venue": "Asian Journal of Ecotoxicology",
        "year": 2007
    },
    "rCow6vC4": {
        "id": "rCow6vC4",
        "title": "Preparation of cellulose tris(4-methylphenylcarbamate) chiral stationary phase and its application",
        "abstract": "Cellulose tris(4-methylphenylcarbamate) was synthesized by the reaction of microcrystalline cellulose with 4-Methylbenzyl isocyanate.The chiral stationary phase was prepared by coating cellulose tris(4-methylphenylcarbamate) on the silica gel.The enantiomers of tebucomazole,diniconazole,paclobutrazol,hexaconazole,miconazole nitrate were separated under the normal phase.The influence of ethanol and isopropanol on the mobile phase hexane was investigated,and the mechanism of chiral recognition was discussed.",
        "keywords": [
            "high performance liquid chromagraphy",
            "chiral stationary phase",
            "cellulose-tris(4-methylphenylcarbamate)",
            "enantioseparation"
        ],
        "authors": [
            {
                "name": "YU Yun-feng",
                "org": "College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "ZHANG Da-tong",
                "org": "College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "JIN LI-xia",
                "org": "College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou ,China"
            }
        ],
        "venue": "Journal of Zhejiang University of Technology",
        "year": 2009
    },
    "aTU1VMX5": {
        "id": "aTU1VMX5",
        "title": "Conversion of nornicotine to 6-hydroxy-nornicotine and 6-hydroxy-myosmine by Shinella sp. strain HZN7.",
        "abstract": "Nornicotine is a natural alkaloid produced by plants in the genus Nicotiana and is structurally related to nicotine. Importantly, nornicotine is the direct precursor of tobacco-specific nitrosamine N'-nitrosonornicotine, which is a highly potent human carcinogen. Microbial detoxification and degradation of nicotine have been well characterized; however, until now, there has been no information on the molecular mechanism of nornicotine degradation. In this study, we demonstrate the transformation of nornicotine by the nicotine-degrading strain Shinella sp. HZN7. Three transformation products were identified as 6-hydroxy-nornicotine, 6-hydroxy-myosmine, and 6-hydroxy-pseudooxy-nornicotine by UV spectroscopy, high-resolution mass spectrometry, nuclear magnetic resonance, and Fourier transform-infrared spectroscopy analyses. The two-component nicotine dehydrogenase genes nctA1 and nctA2 were cloned, and their product, NctA, was confirmed to be responsible for the conversion of nornicotine into 6-hydroxy-nornicotine as well as nicotine into 6-hydroxy-nicotine. The 6-hydroxy-nicotine oxidase, NctB, catalyzed the oxidation of 6-hydroxy-nornicotine to 6-hydroxy-myosmine, and it spontaneously hydrolyzed into 6-hydroxy-pseudooxy-nornicotine. However, 6-hydroxy-pseudooxy-nornicotine could not be further degraded by strain HZN7. This study demonstrated that nornicotine is partially transformed by strain HZN7 via nicotine degradation pathway.",
        "keywords": [
            "6-Hydroxy-myosmine",
            "6-Hydroxy-nicotine oxidase",
            "6-Hydroxy-nornicotine",
            "6-Hydroxy-pseudooxy-nornicotine",
            "Nicotine dehydrogenase",
            "Nornicotine",
            "Shinella sp. HZN7"
        ],
        "authors": [
            {
                "name": "Jiguo Qiu",
                "org": "Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, China."
            },
            {
                "name": "Na Li",
                "org": "Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, China."
            },
            {
                "name": "Zhenmei Lu",
                "org": "College of Life Sciences, Zhejiang University, Hangzhou, 310058, China."
            },
            {
                "name": "Youjian Yang",
                "org": "Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, China."
            },
            {
                "name": "Yun Ma",
                "org": "College of Environment, Zhejiang University of Technology, Hangzhou, 310014, China."
            },
            {
                "name": "Lili Niu",
                "org": "College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China."
            },
            {
                "name": "Jian He",
                "org": "Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, China. hejian@njau.edu.cn."
            },
            {
                "name": "Weiping Liu",
                "org": "College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China."
            }
        ],
        "venue": "Applied microbiology and biotechnology",
        "year": 2016
    },
    "ZwiHyMLz": {
        "id": "ZwiHyMLz",
        "title": "Origin of air pollution during a weekly heavy haze episode in Hangzhou, China",
        "abstract": "Abstract Air pollution has recently become China\u2019s highest environmental issue due to the rapid development of industry and urbanization. So far, the precise sources of air pollution of main cities are unknown. To identify sources, we studied air pollution in the Hangzhou city from November 25 to December 11, 2013, at eight monitoring stations. We analyzed PM2.5, PM10, O3, NO2, CO, SO2, and satellite observations for aerosol optical thickness (PM: particulate matter). Pollution sources were identified by trajectory clustering and receptor models. The results show that during the weekly heavy haze episode, December 3\u20139, mean concentrations were 293.4 \u00b1 103.2 \u03bcg m\u22123 for PM2.5, 376.8 \u00b1 119.4 \u03bcg m\u22123 for PM10, 58.0 \u00b1 37.2 \u03bcg m\u22123 for SO2, 118.5 \u00b1 39.3 \u03bcg m\u22123 for NO2, and 2,429 \u00b1 740 \u03bcg m\u22123 for CO. The back trajectory cluster analysis indicates that the predominant clusters are south (37.1 %) and southeast (28.6 %) during the weekly heavy haze episode. The results of the receptor models show that the sources affecting formation of the extremely high PM2.5 in Hangzhou are mainly located in the southeastern coast of Zhejiang and Fujian provinces, north part of Jiangxi, and central part of Jiangsu province. Rather than local emissions, it is also found that air mass pathways and cross-border transports control high PM2.5 concentrations and formation in Hangzhou. Therefore, it is necessary to implement air pollution control for all industrial areas at local, regional, and national scales in China.",
        "keywords": [
            "Air pollution",
            "Haze",
            "Sources",
            "Back trajectories",
            "Source identification"
        ],
        "authors": [
            {
                "name": "Shaocai Yu",
                "org": "Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, People\u2019s Republic of China"
            },
            {
                "name": "Qingyu Zhang",
                "org": "Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, People\u2019s Republic of China"
            },
            {
                "name": "Renchang Yan",
                "org": "Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, People\u2019s Republic of China"
            },
            {
                "name": "Si Wang",
                "org": "Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, People\u2019s Republic of China"
            },
            {
                "name": "Pengfei Li",
                "org": "Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, People\u2019s Republic of China"
            },
            {
                "name": "Bixin Chen",
                "org": "Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, People\u2019s Republic of China"
            },
            {
                "name": "Weiping Liu",
                "org": "Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, People\u2019s Republic of China"
            },
            {
                "name": "Xiaoyu Zhang",
                "org": "Department of Earth Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, People\u2019s Republic of China"
            }
        ],
        "venue": "Environmental Chemistry Letters",
        "year": 2014
    },
    "lQsXzYDA": {
        "id": "lQsXzYDA",
        "title": "Risks from sediments contaminated with organochlorine pesticides in Hangzhou, China.",
        "abstract": "In September 2009, we investigated the residues, enantiomer fractions (EFs) and biological risks of organochlorine pesticides (OCPs), including dichlorodiphenyltrichloroethanes (DDTs) and hexachlorocyclohexanes (HCHs), in three different depth ranges (0-5 cm, 5-10 cm and 10-15 cm) of sediments from 15 sites in Hangzhou, China. The concentration (ng g(-1) dryweight) ranges of HCHs and DDTs in surface sediments were 0.74-5.8 and 0.76-17, respectively. The vertical distribution of mean OCP concentrations was in the order of 10-15 cm>5-10 cm>0-5 cm and implied that the residues of HCHs and DDTs gradually decreased after they were banned. The residues of OCPs in the study area mainly originated from the historical OCP use. The isomer ratios of <alpha>-HCH (\u03b1-HCH)/<gamma>-HCH (\u03b3-HCH) (0.10-7.6) implied that HCH residues were derived not only from historical technical HCH use but also from additional use of lindane in this area. The isomer ratios of o,p'-DDT/p,p'-DDT (51% of samples were in the range of 0.3-1.3) suggested that both dicofol-type DDT and technical DDT applications may be present in most study areas. The (+)-enantiomers of \u03b1-HCH and o,p'-DDT were more prevalent than (-)-enantiomer in most samples with the fractions contain different enantiomers greater than 0.5. DDTs, especially p,p'-DDE, are the main OCP species of more ecotoxicological concern in Hangzhou.",
        "keywords": [
            "sediments",
            "chirality",
            "residues",
            "organochlorine pesticides",
            "risk assessment"
        ],
        "authors": [
            {
                "name": "Chengwang Wu",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Anping Zhang",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Chemosphere",
        "year": 2013
    },
    "r4rQgyMp": {
        "id": "r4rQgyMp",
        "title": "Occurrence, abundance, and distribution of sulfonamide and tetracycline resistance genes in agricultural soils across China.",
        "abstract": "The prevalence and proliferation of antibiotic resistance genes (ARGs) have been identified as an emerging contaminant of concern and a crucial threat to public health worldwide. In this study, we carried out a nation-wide sampling campaign across China to investigate the distribution and abundances of 8 major ARGs in agricultural soils. The levels of sulfonamide (sul) and tetracycline (tet) resistance genes in China's agricultural soils ranged from 10-10 to 10-10 gene copies/16S rRNA gene copies, respectively. Northeast China is the hot-spot of ARGs, likely due to long-term wastewater irrigation in the area. Redundancy analysis was further performed to assess the influences of environmental variables on ARG abundances. Sulfonamide resistance genes displayed strong correlations with meteorological parameters (mean annual precipitation and temperature), and decreased from north to south. In comparison, tetracycline resistance genes were more closely related to soil organic matter and pH. Co-selection between heavy metals and ARGs was significant among Cu, Hg and sulfonamide resistance genes. This study highlighted the current status of ARG contamination and their influencing factors in China's agricultural soils. Findings are valuable to identify effective management options for reducing the release of antibiotics and control ARG spread in the agriculture sector across the world.",
        "keywords": [
            "Agricultural soil",
            "Antibiotic resistance genes",
            "Potential risk",
            "Relative abundance",
            "Spatial distribution"
        ],
        "authors": [
            {
                "name": "Yuting Zhou",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Lili Niu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Siyu Zhu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Huijie Lu",
                "org": "Institute of Eco-environment, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China; Department of Civil and Environment Engineering, University of Vermont Burlington, VT 05405, United States. Electronic address: luhuijie@zju.edu.cn."
            },
            {
                "name": "Weiping Liu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: wliu@zju.edu.cn."
            }
        ],
        "venue": "The Science of the total environment",
        "year": 2017
    },
    "bo2bwF0T": {
        "id": "bo2bwF0T",
        "title": "Permethrin exposure during puberty has the potential to enantioselectively induce reproductive toxicity in mice.",
        "abstract": "Permethrin (PM), as a chiral pesticide, has two asymmetric centers, resulting in two pairs of enantiomers. In China, the commercial formulation of PM contains four enantiomers. The enantiomer-specific activity for endocrine disruption in mice remains unclear. In the present study, the four individual PM enantiomers were separated by preparative HPLC. Then, three week-old male ICR mice (after maternal ablactation) were orally administered (+)-cis, (-)-cis, (+)-trans, and (-)-trans-PM separately daily for 3 weeks at doses of 0, 25, 50 and 100 mg/kg/day, respectively. The results showed that 100 mg/kg of (+)-cis, (-)-cis and (-)-trans-PM treatments resulted in serious testicular histopathological damage, decreases in testis weight and serum testosterone (T) concentrations. Moreover, the transcription status of some key genes involved in cholesterol synthesis and transport as well as T synthesis in the testes were also influenced selectively by PM enantiomers, especially by the (+)-cis-PM. Additionally, peripheral benzodiazepine receptor (PBR) and 17\u03b2-hydroxysteroid dehydrogenase (17\u03b2-HSD) mRNA levels decreased significantly in the (+)-cis-PM group regardless of the administrated doses, while steroidogenic acute regulatory protein (StAR) levels were significantly down-regulated by (+)-cis and (-)-trans-PM. Moreover, significant differences were mainly found in HMG-CoA reductase, PBR, StAR and 17\u03b2-HSD mRNA levels between different enantiomers. Combined with the effects on physiology, histopathology and the expression of genes related to T synthesis, (+)-cis-PM showed the greatest endocrine disruption activities, (-)-cis and (-)-trans-PM were moderate, while (+)-trans-PM exhibited the lowest. These results suggested significant PM enantioselectivity in the reproductive toxicity of mice during puberty exposure.",
        "keywords": [
            "enantioselectivity",
            "gene expression",
            "permethrin",
            "reproductive toxicity"
        ],
        "authors": [
            {
                "name": "Yuanxiang Jin",
                "org": ""
            },
            {
                "name": "Jingwen Liu",
                "org": ""
            },
            {
                "name": "Linggang Wang",
                "org": ""
            },
            {
                "name": "Rujia Chen",
                "org": ""
            },
            {
                "name": "Cheng Zhou",
                "org": ""
            },
            {
                "name": "Yuefeng Yang",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Zhengwei Fu",
                "org": ""
            }
        ],
        "venue": "Environment international",
        "year": 2012
    },
    "H7zYOog5": {
        "id": "H7zYOog5",
        "title": "Enantioselective Phytotoxicity of the Herbicide Imazethapyr and its Effect on Rice Physiology and Gene Transcription",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "haifeng qian",
                "org": ""
            },
            {
                "name": "zhengwei fu",
                "org": ""
            },
            {
                "name": "hanqi ye",
                "org": ""
            },
            {
                "name": "xinliang chen",
                "org": ""
            },
            {
                "name": "tao lu",
                "org": ""
            },
            {
                "name": "haijia hu",
                "org": ""
            },
            {
                "name": "ruiqin wang",
                "org": ""
            }
        ],
        "venue": "Environmental Science & Technology",
        "year": 2011
    },
    "nXxkeg1q": {
        "id": "nXxkeg1q",
        "title": "Progress in potential toxicity of chiral pesticides",
        "abstract": "In the past,chiral pesticides were explored as racemic mixtures in environmental fate and ecotoxicities.However,as a result of the enantioselective interactions with chiral molecules,the enantiomers of chiral pesticides may have different potential toxicities to humans and animals.The present review introduced recent findings on enantioselective endocrine disruption,neurotoxicity,immunotoxicity,reproductive and developmental toxicity of organophosphorus,organochlorines,pyrethroids and phenylpyrazole pesticides,as well as the underlying mechanisms.Furthermore,the developmental trends of future investigations were discussed.",
        "keywords": [
            "toxic mechanism",
            "enantioselectivity",
            "developmental toxicity",
            "chiral pesticides",
            "neurotoxicity",
            "endocrine disruption",
            "immunotoxicity"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "Institute of Environmental Science,College of Environmental and Resource Sciences,Zhejiang University,Hangzhou ,China"
            },
            {
                "name": "ZHANG Ying",
                "org": "Institute of Environmental Science,College of Environmental and Resource Sciences,Zhejiang University,Hangzhou ,China"
            }
        ],
        "venue": "Journal of Zhejiang University(Agriculture and Life Sciences)",
        "year": 2012
    },
    "QBBhJnu6": {
        "id": "QBBhJnu6",
        "title": "Effects of pesticides metolachlor and S-metolachlor on soil microorganisms in aquisols \u2161Soil respiration",
        "abstract": "An incubation test on the soil microbial respiration as affected by 0,5,20,and 100 mg\u00b7kg~(-1) of metolachlor and S-metolachlor(Dual Gold) showed that at the early period of incubation,5 mg\u00b7kg~(-1) of metolachlor had a stronger stimulation effect on the respiration than 5 mg\u00b7kg~(-1) of Dual Gold,but after then,metolachlor presented an inhibition effect while Dual Gold had the effects of stimulation or recovery.20 mg\u00b7kg~(-1) of Dual Gold had little effect on the respiration,while metolachlor with the same concentration stimulated it.100 mg\u00b7kg~(-1) of metolachlor had a stronger stimulation effect on the respiration than 100 mg\u00b7kg~(-1) of Dual Gold,but both of them had the same inhibition effect during the later period.The higher the concentration of metolachlor or Dual Gold,the greater the stimulation effect was.There was a significant difference in soil microbial respiration between treated and blank soil at the beginning of incubation,while no significant difference was observed during the later period.With the same concentration of 20 or 100 mg\u00b7kg~(-1),metolachlor had more harm than Dual Gold.It was suggested that metolachlor and Dual Gold belonged to lower poisonous pesticides, and had less harm on soil microbes.",
        "keywords": [
            "S-Metolachlor(Dual Gold)",
            "Metolachlor",
            "Soil microorganism.",
            "Soil respiration",
            "Chiral pesticide"
        ],
        "authors": [
            {
                "name": "ZHOU Ying",
                "org": "~1Institute of Environmental Science,Zhejiang University,Hangzhou ,China"
            },
            {
                "name": "LIU Weiping",
                "org": "~1Institute of Environmental Science,Zhejiang University,Hangzhou ,China;~3College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "YE Huina",
                "org": "~2College of Chemical Engineering and Materials Science,Zhejiang University of Technology,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Applied Ecology",
        "year": 2006
    },
    "KY1lRrbX": {
        "id": "KY1lRrbX",
        "title": "Cover Picture: Drug Metabolism by Cytochrome P450 Enzymes: What Distinguishes the Pathways Leading to Substrate Hydroxylation Over Desaturation? (Chem. Eur. J. 25/2015)",
        "abstract": "",
        "keywords": [
            "reaction mechanisms",
            "enzyme catalysis"
        ],
        "authors": [
            {
                "name": "li ji",
                "org": "zhejiang university"
            },
            {
                "name": "abayomi s faponle",
                "org": "university of manchester"
            },
            {
                "name": "matthew g quesne",
                "org": "university of manchester"
            },
            {
                "name": "mala a sainna",
                "org": "university of manchester"
            },
            {
                "name": "jing zhang",
                "org": "zhejiang university"
            },
            {
                "name": "alicja franke",
                "org": "university of erlangen nuremberg"
            },
            {
                "name": "devesh kumar",
                "org": "babasaheb bhimrao ambedkar university"
            },
            {
                "name": "rudi van eldik",
                "org": "faculty of chemistry"
            },
            {
                "name": "weiping liu",
                "org": "zhejiang university"
            },
            {
                "name": "sam p de visser",
                "org": "university of manchester"
            }
        ],
        "venue": "Chemistry: A European Journal",
        "year": 2015
    },
    "Tj0ERAA7": {
        "id": "Tj0ERAA7",
        "title": "Relative effects of open biomass and crop straw burning on haze formation over central and eastern China: modelling study driven by constrained emissions",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Khalid Mehmood",
                "org": "Research Center for Air Pollution and Health; Key Laboratory of Environmental Remediation and Ecological Health, Ministry of Education, College of Environment and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China"
            },
            {
                "name": "Yujie Wu",
                "org": "Research Center for Air Pollution and Health; Key Laboratory of Environmental Remediation and Ecological Health, Ministry of Education, College of Environment and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China"
            },
            {
                "name": "Liqiang Wang",
                "org": "Research Center for Air Pollution and Health; Key Laboratory of Environmental Remediation and Ecological Health, Ministry of Education, College of Environment and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China"
            },
            {
                "name": "Shaocai Yu",
                "org": "Research Center for Air Pollution and Health; Key Laboratory of Environmental Remediation and Ecological Health, Ministry of Education, College of Environment and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China"
            },
            {
                "name": "Pengfei Li",
                "org": "Research Center for Air Pollution and Health; Key Laboratory of Environmental Remediation and Ecological Health, Ministry of Education, College of Environment and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China"
            },
            {
                "name": "Xue Chen",
                "org": "Research Center for Air Pollution and Health; Key Laboratory of Environmental Remediation and Ecological Health, Ministry of Education, College of Environment and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China"
            },
            {
                "name": "Zhen Li",
                "org": "Research Center for Air Pollution and Health; Key Laboratory of Environmental Remediation and Ecological Health, Ministry of Education, College of Environment and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China"
            },
            {
                "name": "Yibo Zhang",
                "org": "Research Center for Air Pollution and Health; Key Laboratory of Environmental Remediation and Ecological Health, Ministry of Education, College of Environment and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China"
            },
            {
                "name": "Mengying Li",
                "org": "Research Center for Air Pollution and Health; Key Laboratory of Environmental Remediation and Ecological Health, Ministry of Education, College of Environment and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China"
            },
            {
                "name": "Weiping Liu",
                "org": "Research Center for Air Pollution and Health; Key Laboratory of Environmental Remediation and Ecological Health, Ministry of Education, College of Environment and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China"
            },
            {
                "name": "Yannian Zhu",
                "org": "Meteorological Institute of Shaanxi Province, 36 Beiguanzhengjie, Xi\u2019an 710015, China"
            },
            {
                "name": "Daniel Rosenfeld",
                "org": "Institute of Earth Sciences The Hebrew University of Jerusalem Jerusalem, Israel"
            },
            {
                "name": "John H. Seinfeld",
                "org": "Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA"
            }
        ],
        "venue": "Atmospheric Chemistry and Physics",
        "year": 2019
    },
    "UFIMyK5P": {
        "id": "UFIMyK5P",
        "title": "Enantioselectivity in chronic toxicology and accumulation of the synthetic pyrethroid insecticide bifenthrin in Daphnia magna.",
        "abstract": "Introduced in the early 1980s, synthetic pyrethroids (SPs) are widely used in controlling a multitude of agricultural and domestic insect species, but they are highly toxic to fish and aquatic invertebrates. To date, however, studies have not adequately associated enantioselectivity in biological behavior with toxicity, especially regarding uptake and chronic toxicity. This study aimed to elucidate the relationship between chronic enantioselective toxicity and enantioselective accumulation of cis-bifenthrin (cis-BF) in Daphnia magna by 14C-labeled assay. The results demonstrated a clear enantioselectivity in chronic toxicity, for which 1R-cis-BF was evidently more toxic to D. magna than 1S-cis-BF. The lowest-observed-effective concentration in terms of survival and fecundity for 1R-cis-BF were almost 40- and 80-fold higher than that of 1S-cis-BF on day 7 and day 14, respectively. Further studies indicated that the accumulation of 1R-cis-BF was approximately 14- to 40-fold more than that of 1S-cis-BF in D. magna. This enantioselective accumulation also was consistent with the enantioselectivity in chronic toxicity of cis-BF. Thus, our results support the notion that enantioselectivity in chronic toxicity may be caused primarily by an enantiomer-specific biological process, such as uptake in aquatic organisms. This suggests that to properly assess the risk associated with use of SPs, the potential for enantioselectivity in their biotransformation and toxicity should be evaluated concurrently.",
        "keywords": [
            "daphnia magna",
            "accumulation",
            "chronic toxicity",
            "bifenthrin",
            "enantioselectivity",
            "fecundity",
            "toxicology"
        ],
        "authors": [
            {
                "name": "Meirong Zhao",
                "org": ""
            },
            {
                "name": "Cui Wang",
                "org": ""
            },
            {
                "name": "Kevin K Liu",
                "org": ""
            },
            {
                "name": "Liwei Sun",
                "org": ""
            },
            {
                "name": "Ling Li",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            }
        ],
        "venue": "Environmental toxicology and chemistry / SETAC",
        "year": 2009
    },
    "tuRHNeJ4": {
        "id": "tuRHNeJ4",
        "title": "Status, influences and risk assessment of hexachlorocyclohexanes in agricultural soils across china.",
        "abstract": "Large amounts of hexaclorocyclohexanes (HCHs) were historically applied to Chinese soils. However, there has been limited information on the residue patterns of HCHs in soils at a national scale in China. In this study, surface soil samples were collected from agricultural fields across China, and the concentrations of HCHs and enantiomeric fractions (EFs) of \u03b1-HCH were measured. The results showed that the average concentrations of \u03b1-HCH, \u03b2-HCH, \u03b3-HCH, and total HCHs in Chinese agricultural soils were 0.190, 1.31, 0.236, and 1.74 ng g(-1), respectively. Residues of HCHs likely originated from past usage of technical HCHs. The isomers of \u03b1-HCH and \u03b3-HCH tended to accumulate in the sites with lower total HCH concentrations, lower temperature, higher elevation, and less wet precipitation when compared to \u03b2-HCH. Enantiomeric analysis showed a preferential degradation of (-)-\u03b1-HCH. Human health risks via various exposure routes to HCHs in soils were further estimated. Overall, the mean hazard index (HI) linked to noncarcinogenic risks was below 1, suggesting an absence of noncarcinogenic risks of HCHs in Chinese soils. In addition, the cancer risk values were all below 10(-4), which indicates low or very low risks.",
        "keywords": [],
        "authors": [
            {
                "name": "Lili Niu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Chao Xu",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Yijun Yao",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Kai Liu",
                "org": "Tsinghua University(Tsinghua University,Tsinghua Univ,Tsinghua Univ.),Beijing,China"
            },
            {
                "name": "Fangxing Yang",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Mengling Tang",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Environmental science & technology",
        "year": 2013
    },
    "FH1cN733": {
        "id": "FH1cN733",
        "title": "Environmental exposure to DDT and its metabolites in cord serum: Distribution, enantiomeric patterns, and effects on infant birth outcomes.",
        "abstract": "Previous in vivo studies have suggested that prenatal exposure to dichlorodiphenyltrichloroethane (DDT) is endocrine disrupting, and may cause adverse health risks to newborns. In this cross-sectional study, non-invasive cord serum samples were collected from maternal-neonate pairs of an island population. Concentrations of DDT and its metabolites were analyzed to provide insights into the environmental exposure patterns and to elucidate their effects on birth outcomes. The average concentrations of p,p'-DDE, o,p'-DDD, p,p'-DDD, o,p'-DDT, p,p'-DDT and total DDTs were 0.463, 0.293, 0.089, 0.098, 0.441 and 1.384\u03bcgg lipid weight, respectively. Several maternal characteristics were identified as influencing factors on the environmental exposure distribution. The isomer ratios of individual components and the enantiomeric patterns of o,p'-DDD and o,p'-DDT indicated that historical technical DDT remains the predominant exposure source, though new sources of dicofol-type of DDT pollution must not be ignored. Using multivariable linear regression, increasing p,p'-DDD and p,p'-DDT levels were found to be significantly associated with an increase in neonatal birth weight, which deserves additional attention to obesity risks. No other birth outcome was found to be significant regarding DDT exposure. These findings raise the awareness of the prenatal risk of DDT and its metabolites among infants in contaminated areas.",
        "keywords": [
            "Birth outcomes",
            "Cord serum",
            "DDT",
            "Enantiomeric patterns",
            "Environmental exposure"
        ],
        "authors": [
            {
                "name": "Chenye Xu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Shanshan Yin",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Mengling Tang",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Kai Liu",
                "org": "Division of Engineering and Applied Science, W. M. Keck Laboratories, California Institute of Technology, 1200 East California Blvd., Pasadena, California 91125, USA."
            },
            {
                "name": "Fangxin Yang",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Weiping Liu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: wliu@zju.edu.cn."
            }
        ],
        "venue": "The Science of the total environment",
        "year": 2017
    },
    "MLdq80FN": {
        "id": "MLdq80FN",
        "title": "Effects of pesticide imidacloprid and its metabolites on soil respiration]",
        "abstract": "Soil respiration was measured using NaOH absorbing technique. Imidacloprid were applied to soil samples at concentration of 0, 10, 40, 100 micrograms.g-1, its hydrolysis and photolysis products were applied at 40 micrograms.g-1. The more significant effect at higher concentration of imidacloprid was observed. The effect of its hydrolysis product was minor than imidacloprid, but the photolysis products of 10 min have stronger effect, the effect decreased greatly in 30 min. Soil respiration recovered after 13 days. It showed that imidacloprid and its metabolites have little effect on soil microorganism.",
        "keywords": [
            "imidacloprid",
            "metabolites",
            "soil respiration"
        ],
        "authors": [
            {
                "name": "H Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "W Zheng",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "W Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Huan jing ke xue= Huanjing kexue / [bian ji, Zhongguo ke xue yuan huan jing ke xue wei yuan hui \"Huan jing ke xue\" bian ji wei yuan hui.]",
        "year": 2001
    },
    "xMRyzIdh": {
        "id": "xMRyzIdh",
        "title": "Disruption of the hormonal network and the enantioselectivity of bifenthrin in trophoblast: maternal-fetal health risk of chiral pesticides.",
        "abstract": "Endocrine-disrupting chemicals (EDCs) can interfere with normal hormone signaling to increase health risks to the maternal-fetal system, yet few studies have been conducted on the currently used chiral EDCs. This work tested the hypothesis that pyrethroids could enantioselectively interfere with trophoblast cells. Cell viability, hormone secretion, and steroidogenesis gene expression of a widely used pyrethroid, bifenthrin (BF), were evaluated in vitro, and the interactions of BF enantiomers with estrogen receptor (ER) were predicted. At low or noncytotoxic concentrations, both progesterone and human chorionic gonadotropin secretion were induced. The expression levels of progesterone receptor and human leukocyte antigen G genes were significantly stimulated. The key regulators of the hormonal cascade, GnRH type-I and its receptor, were both upregulated. The expression levels of selected steroidogenic genes were also significantly altered. Moreover, a consistent enantioselective interference of hormone signaling was observed, and S-BF had greater effects than R-BF. Using molecular docking, the enantioselective endocrine disruption of BF was predicted to be partially due to enantiospecific ER binding affinity. Thus, BF could act through ER to enantioselectively disturb the hormonal network in trophoblast cells. These converging results suggest that the currently used chiral pesticides are of significant concern with respect to maternal-fetal health.",
        "keywords": [],
        "authors": [
            {
                "name": "Meirong Zhao",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology , Hangzhou 310032, China."
            },
            {
                "name": "Ying Zhang",
                "org": ""
            },
            {
                "name": "Shulin Zhuang",
                "org": ""
            },
            {
                "name": "Quan Zhang",
                "org": ""
            },
            {
                "name": "Chengsheng Lu",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            }
        ],
        "venue": "Environmental science & technology",
        "year": 2014
    },
    "L76MBLML": {
        "id": "L76MBLML",
        "title": "Effect of endocrine disrupting chemicals on the transcription of genes related to the innate immune system in the early developmental stage of zebrafish (Danio rerio).",
        "abstract": "Health concerns regarding the potential interference of endocrine disrupting chemicals (EDCs) in the immune system of wildlife and humans have increased in recent years. However, the effects of EDCs in aquatic systems on the immune system of fish species has only received limited attention. In the present study, we found that the mRNA levels of TNFalpha, IFN, IL-1beta, IL-8, CXCL-Clc, and CC-chemokine, which are closely related to the innate immune system, were affected in newly hatched zebrafish when exposed to EDCs, such as 17beta-estradiol, 17alpha-ethynyestradiol, permethrin, atrazine and nonylphenol at various concentrations (0.1, 0.5, 2.5 and 12.5 microg/l) for three days during the embryo stage. However, the different EDCs displayed different potentials to change innate immune-related gene transcription. Among the selected chemicals, permethrin (PM) and 17beta-estradiol (E2) (12.5 microg/l) significantly increased the mRNA levels of many cytokines, exhibiting their most prominent impacts on the innate immune system of zebrafish. In addition, it was found that the mixture of the above five chemicals (2.5 microg/l each) had a greater effect on innate immune system-related gene transcription in zebrafish than equal amounts of the single compound. Moreover, the genes (such as Bcl2, Ucp2 and iNOS) relating to reactive oxygen species (ROS) and nitrogen reactive free radical production were also influenced by some EDCs and their mixture. We suggest that heavy oxidative stress and the balance of nitric oxide (NO) production lead to death of immune cells. These results may provide an explanation of the possible mode how EDCs influence the innate immune system in zebrafish. Taken together, the results obtained in the present study clearly demonstrate that EDCs and their mixtures in aquatic systems will greatly influence the immune system in fish, suggesting that the effects of EDCs on fish should be associated with immune toxicity.",
        "keywords": [
            "innate immune system",
            "endocrine disrupting chemicals",
            "zebrafish",
            "cytokines",
            "gene transcription",
            "embryos",
            "nitrogen",
            "immune system",
            "free radical",
            "innate immunity"
        ],
        "authors": [
            {
                "name": "Yuanxiang Jin",
                "org": ""
            },
            {
                "name": "Rujia Chen",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Zhengwei Fu",
                "org": ""
            }
        ],
        "venue": "Fish & shellfish immunology",
        "year": 2010
    },
    "g4o2AR3Z": {
        "id": "g4o2AR3Z",
        "title": "Permethrin is a potential thyroid-disrupting chemical: In vivo and in silico envidence.",
        "abstract": "Permethrin (PM), one of the most heavily used synthetic pyrethroids, has the potential to interfere with thyroid hormones in mammals, however, the effect is poorly recognized in aquatic organisms. Herein, embryonic zebrafish were exposed to PM (0, 1, 3 and 10\u03bcg/L) until 72h post-fertilization. We demonstrated that PM readily accumulated in larvae with a preference for cis-PM, inhibited development and increased thyroxine and 3,5,3'-triiodothyronine levels accompanying increase in the transcription of most target genes, i.e., thyroid-stimulating hormone \u03b2, deiodinases, thyroid receptors, involved in the hypothalamic-pituitary-thyroid axis. Further Western blot analysis indicated that transthyretin (TTR) protein was significantly increased. Molecular docking analysis and molecular dynamics simulations revealed that PM fits into three hydrophobic binding pocket of TTR, one of the molecular targets of thyroid hormone disrupting chemicals (THDCs), and forms strong van der Waals interactions with six resides of TTR, including Leu8, Leu 101, Leu125, Thr214, Leu218 and Val229, thus altering TTR activity. Both in vivo and in silico studies clearly disclosed that PM potentially disrupts the thyroid endocrine system in fish. This study provides a rapid and cost-effective approach for identifying THDCs and the underlying mechanisms.",
        "keywords": [
            "Modeling",
            "Permethrin",
            "Thyroid hormone",
            "Transthyretin",
            "Zebrafish"
        ],
        "authors": [
            {
                "name": "Wenqing Tu",
                "org": "Research Institute of Poyang Lake, Jiangxi Academy of Sciences, Nanchang 330029, China; College of Environment, Zhejiang University of Technology, Hangzhou 310032, China."
            },
            {
                "name": "Chao Xu",
                "org": "College of Environment, Zhejiang University of Technology, Hangzhou 310032, China."
            },
            {
                "name": "Yuanxiang Jin",
                "org": "College of Environment, Zhejiang University of Technology, Hangzhou 310032, China."
            },
            {
                "name": "Bin Lu",
                "org": "College of Environment, Zhejiang University of Technology, Hangzhou 310032, China."
            },
            {
                "name": "Chunmian Lin",
                "org": "College of Environment, Zhejiang University of Technology, Hangzhou 310032, China."
            },
            {
                "name": "Yongming Wu",
                "org": "Research Institute of Poyang Lake, Jiangxi Academy of Sciences, Nanchang 330029, China."
            },
            {
                "name": "Weiping Liu",
                "org": "College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            }
        ],
        "venue": "Aquatic toxicology (Amsterdam, Netherlands)",
        "year": 2016
    },
    "Eknp0yxV": {
        "id": "Eknp0yxV",
        "title": "Dichlorodiphenyldichloroethylene exposure reduces r-GCS via suppressed Nrf2 in HepG2 cells.",
        "abstract": "p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), the major isomer of persistent 1,1-Bis(4-chlorophenyl)-2,2,2-trichloroethane metabolite, is highly associated with the risk of liver cancer. \u03b3-glutamyl-cysteine synthetase (\u03b3-GCS), which is the rate-limiting enzyme of glutathione (GSH) biosynthesis and an important scavenger of reactive oxygen species (ROS), is considered as a potential therapeutic target for many cancers. However, the association between the body burden of p,p'-DDE and \u03b3-GCS has not been fully established. Here, we indicated that low doses of p,p'-DDE exposure promoted the proliferation and decreased \u03b3-GCS activity of HepG2 cells in a dose- and time-dependent manner. In addition, p,p'-DDE elevated ROS content and attenuated glutathione peroxidase activity. This was accompanied with inhibitions of NF-E2-related factor 2 (Nrf2) at the mRNA and protein levels. ROS inhibitor supplement could significantly reverse these effects. Moreover, the addition of the proteasome inhibitor, MG132, strongly reversed the p,p'-DDE-reduced Nrf2 expression and \u03b3-GCS activity. Consistently, GSH content was in line with the alteration of \u03b3-GCS. Collectively, the results indicate that p,p'-DDE treatment downregulates \u03b3-GCS activity in HepG2 cells by inducing ROS-mediated Nrf2 loss. \u00a9 2014 Wiley Periodicals, Inc. Environ Toxicol, 2014.",
        "keywords": [
            "hepg2",
            "nf-e2-related factor 2",
            "p",
            "p\u2032-dichlorodiphenyldichloroethylene",
            "reactive oxygen species",
            "\u03b3-glutamyl-cysteine synthetase"
        ],
        "authors": [
            {
                "name": "Xiaoting Jin",
                "org": "Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan, 030006, China."
            },
            {
                "name": "Li Song",
                "org": ""
            },
            {
                "name": "Zhuoyu Li",
                "org": ""
            },
            {
                "name": "Ian P Newton",
                "org": ""
            },
            {
                "name": "Meirong Zhao",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            }
        ],
        "venue": "Environmental toxicology",
        "year": 2014
    },
    "TjtSkW9k": {
        "id": "TjtSkW9k",
        "title": "Highly time- and size-resolved fingerprint analysis and risk assessment of airborne elements in a megacity in the Yangtze River Delta, China.",
        "abstract": "The frequent haze episodes in the Yangtze River Delta (YRD) of China have been of great public concern due to the high risks to human health. Therefore, a better understanding of the sources and characteristics of particulate matters (PM) and associated elements is crucial and urgent for haze controlling. In this study, air particulates were collected from six different functional areas in a megacity of the YRD, China in early winter of 2012. Highly time- and size-resolved analysis of PM-elements was conducted to trace their sources. Our results showed that the main donors to particulate elements were crustal dust, followed by traffic and industrial influences due to the mixed residential, commercial and industrial zones at most sites. Anthropogenesis contributed more to the sources of finer particles and associated elements than those of coarser ones. Besides the local emission sources, meteorological conditions also affected the distribution patterns of ambient elements. Furthermore, the risks of hazard metals in PM2.5 and PM1.0 to human health were estimated. The highest non-carcinogenic and carcinogenic risks were observed at urban living quarter (ULQ) and eco-industrial park (EIP), respectively. In addition, the general risks at rural living quarters (RLQ) were the lowest. Results from this study may provide valuable information for air pollution control and management in the YRD, China.",
        "keywords": [
            "Health risk",
            "Hourly variation",
            "Meteorological condition",
            "Particulate element",
            "Size distribution",
            "Source identification"
        ],
        "authors": [
            {
                "name": "Lili Niu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Huajun Ye",
                "org": "State Key Laboratory of Modern Optical Instrument, Zhejiang University, Hangzhou, China."
            },
            {
                "name": "Chao Xu",
                "org": "IJRC-PTS, College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China."
            },
            {
                "name": "Yijun Yao",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Weiping Liu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            }
        ],
        "venue": "Chemosphere",
        "year": 2015
    },
    "45RAfyAR": {
        "id": "45RAfyAR",
        "title": "STUDY ON ENDOCRINE DISRUPTION OF PESTICIDES",
        "abstract": "The endocrine disruption of environmental pollutants has been one of the global environmental concerns.The present reviewdescribed some characteristics of the environmental endocrine disrupting chemicals and their measuring and assaying methods.More attentions were given to endocrine disrupting impacts of agrochemicals such as insecticides,herbicides and fungicides,especially chiral pesticides.",
        "keywords": [
            "endocrine disruption",
            "pesticides",
            "environmental endocrine disrupting chemicals."
        ],
        "authors": [
            {
                "name": "WANG Lu-mei",
                "org": " Institute of Environmental Science,Zhejiang University,Hangzhou,,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": " Institute of Environmental Science,Zhejiang University,Hangzhou,,China; Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou,,China"
            },
            {
                "name": "MA Yun",
                "org": " Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou,,China"
            },
            {
                "name": "LIN Kun-de",
                "org": " Institute of Environmental Science,Zhejiang University,Hangzhou,,China"
            }
        ],
        "venue": "Environmental Chemistry",
        "year": 2006
    },
    "bWGPe3IZ": {
        "id": "bWGPe3IZ",
        "title": "Occurrence and risk assessment of organophosphate esters in drinking water from Eastern China",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jinjian ding",
                "org": ""
            },
            {
                "name": "xiaoli shen",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "adrian covaci",
                "org": ""
            },
            {
                "name": "fangxing yang",
                "org": ""
            }
        ],
        "venue": "Science of The Total Environment",
        "year": 2015
    },
    "HgSHjpp1": {
        "id": "HgSHjpp1",
        "title": "Effects of glufosinate on antioxidant enzymes, subcellular structure, and gene expression in the unicellular green alga Chlorella vulgaris.",
        "abstract": "Greater exposure to herbicide increases the likelihood of harmful effects in humans and the environment. Glufosinate, a non-selective herbicide, inhibits glutamine synthetase (GS) and thus blocks ammonium assimilation in plants. In the present study, the aquatic unicellular alga Chlorella vulgaris was chosen to assess the effects of acute glufosinate toxicity. We observed physiological changes during 12-96 h of exposure, and gene transcription during 6-48 h of exposure. Exposure to glufosinate increased malondialdehyde content by up to 2.73 times compared with the control, suggesting that there was some oxidative damage. Electron microscopy also showed that there were some chloroplast abnormalities in response to glufosinate. The activities of the antioxidant enzymes superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT) also increased markedly in the presence of glufosinate. Maximum activities of SOD, POD, and CAT were 2.90, 2.91, and 2.48 times that of the control, respectively. These elevated activities may help alleviate oxidative damage. A real-time polymerase chain reaction (PCR) assay showed changes in transcript abundances of three photosynthetic genes, psaB, psbC, and rbcL. The results showed that glufosinate reduced the transcript abundances of the three genes after 12h exposure. The lowest abundances of psaB, psbC and rbcL transcripts in response to glufosinate exposure were 38%, 16% and 43% of those of the control, respectively. Our results demonstrate that glufosinate affects the activities of antioxidant enzymes, disrupts chloroplast ultrastructure, and reduces transcription of photosynthesis-related genes in C. vulgaris.",
        "keywords": [
            "enzyme",
            "real time polymerase chain reaction",
            "gene transcription",
            "enzyme assay",
            "gene expression",
            "electron microscopy",
            "real time pcr",
            "peroxidase"
        ],
        "authors": [
            {
                "name": "Haifeng Qian",
                "org": ""
            },
            {
                "name": "Wei Chen",
                "org": ""
            },
            {
                "name": "G Daniel Sheng",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, People's Republic of China"
            },
            {
                "name": "Xiaoyan Xu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, People's Republic of China"
            },
            {
                "name": "Weiping Liu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, People's Republic of China"
            },
            {
                "name": "Zhengwei Fu",
                "org": ""
            }
        ],
        "venue": "Aquatic toxicology (Amsterdam, Netherlands)",
        "year": 2008
    },
    "pTjtfeGS": {
        "id": "pTjtfeGS",
        "title": "Inhibitory effects of atrazine on Chlorella vulgaris as assessed by real-time polymerase chain reaction.",
        "abstract": "Atrazine, a highly toxic herbicide, is frequently detected in surface water because of its heavy application. Algae are among the aquatic organisms most susceptible to atrazine pollution in water. In the present study, the aquatic alga Chlorella vulgaris Beijerinck was chosen to assess the acute toxicity of atrazine (48-96 h) in terms of gene transcription and physiological changes. A real-time polymerase chain reaction (PCR) assay was used to quantify transcript levels of three photosystem genes in C. vulgaris. The diel patterns for regulation of the psaB (photosystem I reaction center protein subunit B), psbC (an integral membrane protein component of photosystem II), and rbcL (large subunit of ribulose-1,5-bisphosphate carboxylase oxygenase) gene transcripts were successfully quantified. Results showed that atrazine reduced the transcript abundances of three target genes and that the abundances decreased with increasing atrazine concentration. The determined smallest transcript levels of psaB, psbC, and rbcL, which occurred at the highest atrazine concentration tested (400 mug/L), were only 34.6, 34.6, and 8.1%, respectively, of the control sample value. Exposure to atrazine increased the level of malondialdehyde by 1.74-fold (the highest value) in C. vulgaris, suggesting potential oxidative damage to the alga. The activities of antioxidation enzymes (e.g., superoxide dismutase, peroxidase, and catalase) also increased markedly in the presence of atrazine, with maximum increases of 1.82-, 1.59-, and 2.31-fold, respectively. These elevated activities may help to alleviate the oxidative damage. Our results demonstrate that atrazine is highly toxic to this alga and that real-time PCR is an efficient technique for assessing the toxicity of xenobiotic compounds in algae.",
        "keywords": [
            "atrazine",
            "chlorella vulgaris",
            "enzyme assay",
            "real-time polymerase chain reaction",
            "real time polymerase chain reaction"
        ],
        "authors": [
            {
                "name": "Haifeng Qian",
                "org": ""
            },
            {
                "name": "G Daniel Sheng",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Yingcong Lu",
                "org": ""
            },
            {
                "name": "Zhenghai Liu",
                "org": ""
            },
            {
                "name": "Zhengwei Fu",
                "org": ""
            }
        ],
        "venue": "Environmental toxicology and chemistry / SETAC",
        "year": 2008
    },
    "6PCaujfD": {
        "id": "6PCaujfD",
        "title": "Enantioselective induction of cytotoxicity by o,p'-DDD in PC12 cells: implications of chirality in risk assessment of POPs metabolites.",
        "abstract": "The increased release of chiral persistent organic pollutants (POPs) into the environment has resulted in more attention to the role of enantioselectivity in the fate and ecotoxicological effects of these compounds. Although the enantioselectivity of chiral POPs has been considered in previous studies, little effort has been expended to discern the enantiospecific effects of chiral POPs metabolites, which may impede comprehensive risk assessments of these chemicals. In the present study, o,p'-DDD, the chiral metabolite of o,p'-DDT, was used as a model chiral metabolite. First, a preferential chiral separation at 100% ethanol was employed to obtain a pure enantiomer. The enantioselective cytotoxicity of o,p'-DDD in rat cells (PC12) was evaluated by detecting activation of the cellular apoptosis and oxidative stress systems and microarray analysis. We have documented for the first time that R-(+)-o,p'-DDD increases apoptosis by selectively disturbing the oxidative system (enzymes and molecules) and regulating the transcription of Aven, Bid, Cideb and Tp53. By comparing the data from the present study to data derived from the parent compound, we concluded that the R-enantiomer is the more detrimental stereostructure for both o,p'-DDT and o,p'-DDD. This observed stereostructural effect is in line with the structure-activity relationship formulated at other structural levels. Biological activities of the chiral metabolites are likely to occur in the same absolute configuration between chiral POPs and their metabolites provided that they have the similar stereostructures.",
        "keywords": [],
        "authors": [
            {
                "name": "Cui Wang",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Zhuoyu Li",
                "org": "Shanxi University(Shanxi University),Taiyuan,China"
            },
            {
                "name": "Quan Zhang",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Meirong Zhao",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Environmental science & technology",
        "year": 2013
    },
    "HTFdrDrc": {
        "id": "HTFdrDrc",
        "title": "The Enantioseparation of O,O-Dimethyl-1-(phenoxyacetoxy) ethylphosphonate and O,O-Dimethyl-1-(4-methylphenoxyacetoxy) ethylphosphonate by HPLC",
        "abstract": "The effect of chromatographic conditions including type and proportion of alcohol modifiers and column temperature to resoluting enantiomers of the O,O-dimethyl-1-(phenoxyacetoxy)ethylphosphonate and O,O-dim-ethyl-1-(4-methylphenoxyacetoxy)ethylphosphonate using amylose-tris-(3,5-dimethylphenylcarbamate) chiral sta-tionary phase(chiralpak AD-H columns) on High-performance Liquid Chromatography were studied.Thermodynami-cal mechanism of enantio separation have also been preliminary discussed.In this study,baseline separation of the enantiomers of both analytes were obtained with a mobile phase of n-hexane/isopropanol(90:10,by vol) at a flow rate of 1.0 mL/min under 25 oC on the Chiralpak AD-H column.",
        "keywords": [
            "HPLC",
            "chiral pesticdes",
            "chiral stationary phase",
            "enantioseparation"
        ],
        "authors": [
            {
                "name": "YAO Hua-zhen",
                "org": "Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou ,China;Hangzhou Wanxiang Polytechnic,Hangzhou ,China"
            },
            {
                "name": "HU Jian-hua",
                "org": "Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou ,China;Hangzhou Wanxiang Polytechnic,Hangzhou ,China"
            },
            {
                "name": "ZHOU Shan-shan",
                "org": "Institute of Environmental Science,Zhejiang University,Hangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou ,China"
            }
        ],
        "venue": "Agrochemicals",
        "year": 2009
    },
    "3ReQKtbV": {
        "id": "3ReQKtbV",
        "title": "Progress in the Mechanism of Action and Ecological Effects of the Herbicide Diclofop-methyl",
        "abstract": "Diclofop-methyl (DM) is an aryloxyphenoxypropanoic acid herbicide first registered by Farbwerke Hoechst AG for the control of wild oat and other annual grasses.It\u2019s reported that while coming into contact with the soil,a rapid hydrolysis of DM to the corresponding acid form was followed by a much slower hydrolytic process to some trace breakdown products,which may be affected by soil organic matter,pH,aerobic and anaerobic conditions and other factors.Both the parent compound DM and the main degradation product diclofop acid(DC) are herbicidally bioactive,meanwhile cause ecological toxicity such as acute/chronic toxicity,endocrine disrupting effects and proliferation of peroxisomes to non-target organisms like fish and mammals.Furthermore,several biotypes resistant to DM were reported recently to be evolving as the predominant species,which consequently increase more environmental stress.The environmental behavior and ecological effects of DM as well as the mechanisms of resistance to DM were reviewed,and some problems,e.g.lack of data for the ecological toxicity especially in the enantioselectivity of DM,were discussed.Further research suggestions were proposed based on these findings.",
        "keywords": [
            "environmental behavior",
            "diclofop-methyl",
            "ecological effects",
            "chirality",
            "degradation products"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "Institute of Environmental Science,Zhejiang University,Hangzhou ,China;Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "JIN Mei-qing",
                "org": "Institute of Environmental Science,Zhejiang University,Hangzhou ,China"
            },
            {
                "name": "CAI Xi-yun",
                "org": "Research Laboratory of Environmental Ecology and Technology,Department of Environmental Science and Technology,Dalian University of Technology,Dalian ,Liaoning Province,China"
            },
            {
                "name": "YE Jing",
                "org": "Institute of Environmental Science,Zhejiang University,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Pesticide Science",
        "year": 2008
    },
    "vMqJcP5P": {
        "id": "vMqJcP5P",
        "title": "Enantioselective phytoeffects of chiral pesticides.",
        "abstract": "Chirality exists extensively in nature. Synthetic chiral plant growth regulators and other pesticides usually behave enantioselectively in phyto-biochemical processes. Chiral plant growth regulators regulate the physiological processes of plants enantioselectively, and chiral pesticides cause enantioselective toxicities or ecotoxicities to plants. On the other hand, these chiral agrochemicals can be absorbed and enantioselectively metabolized by plants. This review summarizes the enantioselective effects of chiral plant growth regulators on plants and the phytotoxic and biotransformation effects of chiral herbicides and several persistent organic pollutants (POPs) on plants. Together, this information on the interactions between chiral agrochemicals and plants might shed light on studies on the chemical and biological behaviors of chiral chemicals, and direct research into the selection of plants, which can potentially decontaminate the environment.",
        "keywords": [
            "phytotoxicity",
            "pops",
            "herbicides",
            "nontarget plants",
            "chiral pesticides",
            "plant growth regulators",
            "phytoremediation",
            "enantiomers",
            "pollutants",
            "pesticides"
        ],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Jing Ye",
                "org": ""
            },
            {
                "name": "Meiqing Jin",
                "org": ""
            }
        ],
        "venue": "Journal of agricultural and food chemistry",
        "year": 2009
    },
    "6lGUfiGL": {
        "id": "6lGUfiGL",
        "title": "Interaction of S-Metolachlor with Calf Thymus DNA",
        "abstract": "The interaction of S-metolachlor with calf thymus DNA(ctDNA) was investigated using UV absorption spectra,fluorescence spectra,thermal denaturation and viscometry of DNA.The experimental results from UV absorption spectra show that when S-metolachlor was added,the red shift and hypochromic effect were observed in the absorption peak of ctDNA at 200 nm,while its effect on the absorption peak at 260 nm was very little,which indicate that the intercalation binding could be excluded.Moreover,the experimental results of the thermal denaturation and viscometry of ctDNA also excluded the possibility of the intercalation binding between the S-metolachlor and ctDNA.The fluorescence spectra indicate the intrinsic fluorescence of S-metolachlor could be strongly quenched by ctDNA,and with the temperature increasing,its quenching effect decreased,which suggest that the adducts of S-metolachlor and ctDNA were formed,and the binding constants were calculated.In addition,it was suggested from the results of the effect of the ion strength on the fluore-scence system of the S-metolachlor-ctDNA that the electrostatic binding was also excluded.So,the possible binding mode between S-metolachlor and ctDNA was the groove binding according to the above experimental results.",
        "keywords": [
            "Binding mode",
            "Calf thymus DNA",
            "Fluorescence spectrum",
            "Metolachlor",
            "Thermal denaturation",
            "Viscometry"
        ],
        "authors": [
            {
                "name": "TONG Chang-Lun",
                "org": "Key Laboratory of Environment Remediation and Ecological Health,Ministry of Education,College of Environmental and Resource Sciences,Zhejiang University,Hangzhou ,China"
            },
            {
                "name": "YE Rong-Min",
                "org": "Key Laboratory of Environment Remediation and Ecological Health,Ministry of Education,College of Environmental and Resource Sciences,Zhejiang University,Hangzhou ,China"
            },
            {
                "name": "ZHANG Quan",
                "org": "College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "LIU Wei-Ping",
                "org": "Key Laboratory of Environment Remediation and Ecological Health,Ministry of Education,College of Environmental and Resource Sciences,Zhejiang University,Hangzhou ,China;College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou ,China"
            }
        ],
        "venue": "Chemical Journal of Chinese Universities",
        "year": 2010
    },
    "2grAxFCb": {
        "id": "2grAxFCb",
        "title": "Probing the Molecular Interaction of Triazole Fungicides with Human Serum Albumin by Multispectroscopic Techniques and Molecular Modeling",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "changlun tong",
                "org": ""
            },
            {
                "name": "shulin zhuang",
                "org": ""
            },
            {
                "name": "jing zhang",
                "org": ""
            }
        ],
        "venue": "Journal of Agricultural and Food Chemistry",
        "year": 2013
    },
    "uzIBYLFh": {
        "id": "uzIBYLFh",
        "title": "Metabolic Susceptability of 2-Chlorothioxanthone and Its Toxic Effects on mRNA and Protein Expression and Activities of Human CYP1A2 and CYP3A4 Enzymes.",
        "abstract": "Thioxanthones (TXs) are photoinitiators widely used in UV curable resins and food packaging, and their residues have been frequently detected in human bodies. Our current understanding of the susceptibility of residual thioxanes to metabolism and their effects on human health is very limited. The in vitro metabolism of TXs and its toxic effects on cytochrome P450 (CYP) (the key xenobiotic metabolizing enzymes) were examined in this study. 2-Chlorothioxanthone (2-Cl-TX) significantly inhibited the enzymatic activities of CYP1A2 and CYP3A4 with IC50 of 8.36 and 0.86 \u03bcM, respectively. The exposure to 2-Cl-TX at 2.5 \u03bcM up-regulated the mRNA expression of CYP1A2 and CYP3A4 in human hepatocellular carcinoma cells to 3.03-fold and 2.02-fold, respectively. 2-Cl-TX at 2.5 \u03bcM caused 2.19-fold and 1.98-fold overexpression of CYP1A2 and CYP3A4, respectively. In vitro studies revealed that 2-Cl-TX was biotransformed into two metabolites through the sulfoxidation of the sulfur atoms, or via the hydroxylation of aromatic carbon. Results from this study, including the metabolic susceptibility of residual 2-Cl-TX, the proposed metabolites and the significant toxic effect on the activities, mRNA and protein expression of CYP1A2 and CYP3A4, are vital to the human health and safety risk assessment from this ubiquitous xenobiotic.",
        "keywords": "",
        "authors": [
            {
                "name": "Tingjie Zhan",
                "org": "College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, P. R. China"
            },
            {
                "name": "Liumeng Pan",
                "org": "College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, P. R. China"
            },
            {
                "name": "Zhenfeng Liu",
                "org": "The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, P. R. China"
            },
            {
                "name": "Jiayan Chen",
                "org": "College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, P. R. China"
            },
            {
                "name": "Zhiwei Ge",
                "org": "Analysis Center of Agrobiology and Environmental Sciences, Zhejiang University, Hangzhou 310058, P. R. China"
            },
            {
                "name": "Liping Lu",
                "org": "College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, P. R. China"
            },
            {
                "name": "Xiaofang Zhang",
                "org": "College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, P. R. China"
            },
            {
                "name": "Shixuan Cui",
                "org": "College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, P. R. China"
            },
            {
                "name": "Chunlong Zhang",
                "org": "Department of Biological and Environmental Sciences, University of Houston-Clear Lake, 2700 Bay Area Boulevard, Houston, Texas 77058, United States"
            },
            {
                "name": "Weiping Liu",
                "org": "College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, P. R. China"
            },
            {
                "name": "Shulin Zhuang",
                "org": "College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, P. R. China"
            }
        ],
        "venue": "Environmental science & technology",
        "year": 2018
    },
    "OJZoo9BP": {
        "id": "OJZoo9BP",
        "title": "The environmental interfacial process and ecological risk of chiral persistent organic pollutants: A review",
        "abstract": "Scientific research on environmental interfacial process, ecological and health risk of chiral persistent organic pollutants (POPs) has become a groundbreaking topic, since the growing of the unsymmetrical molecular introduction. The enantioselectivity between enantiomers of parental POPs has risen increasing concerned about their enantiospecific in ecological and health risk albeit for the short history of chiral POPs research. This study conducts a comprehensive review on enantiospecific effects of chiral POPs including environmental transportation and transformation, bio-accumulation, toxic effects as well as risk assessment.",
        "keywords": [
            "environmental fate",
            "persistent organic pollutants (pops)",
            "toxicological effect",
            "chirality"
        ],
        "authors": [
            {
                "name": "ZHANG Quan",
                "org": " College of Environmental and Resource Sciences, Zhejiang University, Hangzhou , China; College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou , China"
            },
            {
                "name": "WANG Cui",
                "org": " College of Environmental and Resource Sciences, Zhejiang University, Hangzhou , China; College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou , China"
            },
            {
                "name": "ZHAO MeiRong",
                "org": " College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou , China"
            },
            {
                "name": "LIU WeiPing",
                "org": " College of Environmental and Resource Sciences, Zhejiang University, Hangzhou , China"
            }
        ],
        "venue": "Scientia Sinica(Chimica)",
        "year": 2013
    },
    "CmJHSxkJ": {
        "id": "CmJHSxkJ",
        "title": "Enrichment of steroid hormones in water with porous and hydrophobic polymer-based SPE followed by HPLC-UV determination.",
        "abstract": "There have been great concerns about the persistence of steroid hormones in surface water. Since the concentrations of these compounds in water samples are usually at a trace level, the efficient enrichment of steroid hormones is vital for further analysis. In this work, a porous and hydrophobic polymer was synthesized and characterized. The composition of solvent used as porogen in the synthetic process was shown to have an effect on the morphology of the polymer, which was successfully used as an SPE sorbent for simultaneously enriching steroid hormones in surface water samples. The recoveries of the steroid hormones on the custom-made polymer ranged from 93.4 to 106.2%, whereas those on commercialized ENVI-18, LC-18, and Oasis HLB ranged from 54.8 to 104.9, 66 to 93.6, and 77.2 to 106%, respectively. Five types of steroid hormones were simultaneously measured using HPLC-UV after they were enriched by the custom-made sorbent. Based on these findings, the SPE-HPLC method was developed. The LODs of this method for estriol, estradiol, estrone, androstenedione, progesterone were 0.07, 0.43, 0.61, 0.27, and 0.42 \u03bcg/L, respectively, while precision and reproducibility RSDs were <6.40 and 7.49%, respectively.",
        "keywords": [
            "hplc",
            "steroid hormones",
            "sorbents",
            "hydrophobic interactions",
            "solid-phase extraction",
            "solid phase extraction"
        ],
        "authors": [
            {
                "name": "Yinfen Hu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Man Zhang",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Changlun Tong",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Jianmin Wu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Journal of separation science",
        "year": 2013
    },
    "6mw2LBsx": {
        "id": "6mw2LBsx",
        "title": "Kinetics of electrochemical dechlorination of 2-chlorobiphenyl on apalladium-modified nickel foam cathode in a basic medium:From batch to continuous reactor operation",
        "abstract": "A kinetic model for the electrochemical dechlorination of polychlorinated biphenyls (PCBs) will be animportant contribution to the design and optimization of a continuous reactor. Initially, the electro-catalytic hydrodechlorination of 2-chlorobiphenyl (2-ClBP) to biphenyl at a palladium-modified nickelfoam (Pd/Ni) cathode in a batch reactor was used as a model reaction for a quantitative study of theinfluences of the operating parameters, including temperature, the initial concentrations of PCBs, cur-rent density and the amount of Pd loading, on the apparent reaction rate. The dechlorination was foundto follow pseudo first-order kinetics with respect to the 2-ClBP concentration. It was also found that asimple global power law rate equation, with Arrhenius dependency, can be used to describe the correla-tion between the pseudo first-order reaction rate constants and the reaction conditions. Subsequently,a mathematical model for predicting the performance of reductive dechlorination of 2-ClBP on Pd/Nielectrodes in a continuous stirred tank reactor was constructed, based on the batch-reaction kinetics.The suitability of the model was validated by performing experiments in and out of the range of reactionconditions applied in the batch reactor. The results show that the calculated values are a good fit to theexperimental data. \u00a9 2013 Elsevier Ltd. All rights reserved.",
        "keywords": [
            "2-chlorobiphenyl",
            "Continuous stirred tank reactor",
            "Electrochemical dechlorination",
            "Kinetics model",
            "Palladium-modified nickel foam"
        ],
        "authors": [
            {
                "name": "Zhiqiao He",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Keji Lin",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Junjun Sun",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Lina Wen",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Chao Gao",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Jianmeng Chen",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Shuang Song",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Yanyun Qian",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Weiping Liub",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            }
        ],
        "venue": "Electrochimica Acta",
        "year": 2013
    },
    "H8bAf2fS": {
        "id": "H8bAf2fS",
        "title": "The effect of exogenous nitric oxide on alleviating herbicide damage in Chlorella vulgaris.",
        "abstract": "Herbicides present in the environment induce oxidative stress in plants. We investigated the roles of exogenous NO-regulated chlorophyll synthesis, antioxidant enzyme activity and gene expression in herbicide-treated unicellular green algae Chlorella vulgaris. Atrazine (100 microg/L) or glufosinate (10 mg/L) treatment alone or in combination with 20 microM sodium nitroprussiate (SNP, 10 microM with glufosinate) was administered to algae for a short time period of 48 h to observe changes in physiology and gene transcription and expression. Supplementation of atrazine or glufosinate with low SNP significantly reduced H2O2, reactive oxygen species (ROS) and malondialdehyde (MDA) induction by herbicides. Supplementation also increased chlorophyll content and antioxidant enzymes, superoxide dismutase (SOD), peroxidase (POD) and catalase (CAT) activity, as compared to herbicide treatment alone. This trend suggests an effect of NO on the scavenging of ROS. Furthermore, the expression of photosynthesis genes (psbC, psaB, chlB and rbcL) was also upregulated by supplementation of low SNP, thus maintaining the normal photosynthetic function. However, high concentration of SNP (100 microM) in combination with herbicides aggravated damage to algae, including increases in H2O2, ROS and MDA and decreases in chlorophyll content, antioxidant enzyme activity and photosynthesis genes transcription. 2-Phenyl-4,4,5,5-tetramethyl-imidazoline-1-oxyl-3-oxide (PTIO), the NO scavenger, was also examined in this study; the results showed that PTIO could neutralise the effect of low SNP. Data also showed that an exogenous supply of NO protects Chlorella vulgaris against the toxicity of herbicides by protecting against oxidant substances and increasing the transcription of related genes.",
        "keywords": [
            "gene expression",
            "snp",
            "herbicide",
            "nitric oxide",
            "oxidative stress",
            "peroxidase",
            "gene transcription",
            "aquatic plants",
            "enzyme activity",
            "photosynthesis",
            "hydrogen peroxide",
            "transcription",
            "genes",
            "enzymes",
            "biosynthesis"
        ],
        "authors": [
            {
                "name": "Haifeng Qian",
                "org": ""
            },
            {
                "name": "Wei Chen",
                "org": ""
            },
            {
                "name": "Jingjing Li",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, PR China"
            },
            {
                "name": "Jie Wang",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, PR China"
            },
            {
                "name": "Zhen Zhou",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, PR China"
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Zhengwei Fu",
                "org": ""
            }
        ],
        "venue": "Aquatic toxicology (Amsterdam, Netherlands)",
        "year": 2009
    },
    "o9N5OfGN": {
        "id": "o9N5OfGN",
        "title": "Enoxacin-Tb3+ complex as an environmentally friendly fluorescence probe for DNA and its application.",
        "abstract": "The fluorescence intensity of the enoxacin (ENX)-Tb(3+) complex enhanced by DNA was studied. On the basis of this study, an environmentally friendly fluorescence probe of enoxacin-Tb(3+) for the determination of single-stranded and double-stranded DNA was developed. Under the optimal conditions, the enhanced fluorescence intensity was in proportion to the concentration of DNA in the range of 2.0x10(-8) to 2.0x10(-6)g mL(-1) for hsDNA, 1.0x10(-8) to 1.0x10(-6)g mL(-1) for ctDNA and 5.0x10(-9) to 1.0x10(-6)g mL(-1) for thermally denatured ctDNA. The detection limits (S/N=3) were 5.0, 9.0 and 3.0ng mL(-1), respectively. The interaction modes between ENX-Tb(3+) and DNA and the mechanism of the fluorescence enhancement were also discussed in details. The experimental results from UV absorption spectra, fluorescence spectra and the competing combination tests between the ENX-Tb(3+) complex and EB probe indicated that the possible interaction modes between enoxacin-Tb(3+) complex and DNA had at least two different binding modes: the electrostatic binding and the intercalation binding. Additionally, this fluorescence probe was used to study the interaction between heavy metals and DNA.",
        "keywords": [
            "dna",
            "enx-tb3+ complex",
            "fluorimetry",
            "interaction"
        ],
        "authors": [
            {
                "name": "Changlun Tong",
                "org": ""
            },
            {
                "name": "Zhou Hu",
                "org": "Institute of Environmental Science, Ministry of Education Key Laboratory of Environmental Remediation and Ecological Health, Zhejiang University, Hangzhou 310029, China"
            },
            {
                "name": "Weiping Liu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            }
        ],
        "venue": "Talanta",
        "year": 2007
    },
    "jXkQRaNK": {
        "id": "jXkQRaNK",
        "title": "Enantioselectivity in biotransformation and bioaccumulation processes of typical chiral contaminants",
        "abstract": "Abstract   Chirality is a critical topic in the medicinal and agrochemical fields. One quarter of all agrochemicals was chiral in 1996, and this proportion has increased remarkably with the introduction of new compounds over time. Despite scientists have made great efforts to probe the enantiomeric selectivity of chiral chemicals in the environment since early 1990s, the different behaviours of individual enantiomers in biologically mediated processes are still unclear. In the present review, we highlight state-of-the-knowledge on the stereoselective biotransformation and accumulation of chiral contaminants in organisms ranging from invertebrates to humans. Chiral insecticides, fungicides, and herbicides, polychlorinated biphenyls (PCBs), pharmaceuticals, flame retardants hexabromocyclododecane (HBCD), and perfluorooctane sulfonate (PFOS) are all included in the target compounds. Key findings included: a) Changes in the enantiomeric fractions  in\u00a0vitro  and  in\u00a0vivo  models revealed that enantioselectivity commonly occurs in biotransformation and bioaccumulation. b) Emerging contaminants have become more important in the field of enantioselectivity together with their metabolites in biological transformation process. c) Chiral signatures have also been regarded as powerful tools for tracking pollution sources when the contribution of precursor is unknown. Future studies are needed in order to understand not only preliminary enrichment results but also detailed molecular mechanisms in diverse models to comprehensively understand the behaviours of chiral compounds.",
        "keywords": "",
        "authors": [
            {
                "name": "Chenye Xu",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation and Ecosystem Health, Institute of Environmental Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China"
            },
            {
                "name": "Xinmeng Lin",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation and Ecosystem Health, Institute of Environmental Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China"
            },
            {
                "name": "Shanshan Yin",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation and Ecosystem Health, Institute of Environmental Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China"
            },
            {
                "name": "Lu Zhao",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation and Ecosystem Health, Institute of Environmental Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China"
            },
            {
                "name": "Yingxue Liu",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation and Ecosystem Health, Institute of Environmental Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China"
            },
            {
                "name": "Kai Liu",
                "org": "Department of Environmental Science and Engineering, W. M. Keck Laboratories, California Institute of Technology, 1200 East California Blvd., Pasadena, CA, 91125, USA"
            },
            {
                "name": "Fang Li",
                "org": "School of Environmental Science and Engineering, Donghua University, Shanghai, 201620, China"
            },
            {
                "name": "Fangxing Yang",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation and Ecosystem Health, Institute of Environmental Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China"
            },
            {
                "name": "Weiping Liu",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation and Ecosystem Health, Institute of Environmental Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China"
            }
        ],
        "venue": "Environmental Pollution",
        "year": 2018
    },
    "6YrbDCrl": {
        "id": "6YrbDCrl",
        "title": "Enantioselective Physiological Effects of the Herbicide Diclofop on Cyanobacterium Microcystis aeruginosa",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "zhijian zhang",
                "org": ""
            },
            {
                "name": "lumei wang",
                "org": ""
            },
            {
                "name": "jing ye",
                "org": ""
            }
        ],
        "venue": "Environmental Science & Technology",
        "year": 2013
    },
    "P4lvfzOA": {
        "id": "P4lvfzOA",
        "title": "Carbonaceous sulfur-containing chitosan\u2013Fe(III): A novel adsorbent for efficient removal of copper (II) from water",
        "abstract": "",
        "keywords": [
            "sulfur",
            "carbonization",
            "adsorption"
        ],
        "authors": [
            {
                "name": "yuezhong wen",
                "org": ""
            },
            {
                "name": "jianqing ma",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "chensi shen",
                "org": ""
            },
            {
                "name": "hong li",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            }
        ],
        "venue": "Chemical Engineering Journal",
        "year": 2015
    },
    "VYKtKhGN": {
        "id": "VYKtKhGN",
        "title": "Enantioselective thyroid disruption in zebrafish embryo-larvae via exposure to environmental concentrations of the chloroacetamide herbicide acetochlor.",
        "abstract": "Acetochlor (ACT) is a chiral chloroacetamide pesticide that has been heavily used around the world, resulting in its residues being frequently found in surface waters. It has been reported that ACT is an endocrine disrupting chemical (EDC) with strong thyroid hormone-disrupting activity in aquatic organisms. However, the enantioselectivity underlying thyroid disruption has yet to be understood. In this study, using a zebrafish embryo-larvae model, the enantioselective thyroid disruption of ACT was investigated at a series of environmentally relevant concentrations (1, 2, 10 and 50\u202f\u03bcg/L). Our results showed that both racemic ACT and its enantiomers significantly increased the malformation rates of embryos at 72\u202fh postfertilization (hpf). Decreased thyroxine (T) contents and increased triiodothyronine (T) contents were found in larvae at 120\u202fhpf, with (+)-S-ACT exhibiting a greater effect than (-)-R-enantiomer. Similarly, (+)-S-ACT also showed a stronger effect on the mRNA expressions of thyroid hormone receptors (TR\u03b1 and TR\u03b2), deiodinase2 (Dio2) and thyroid-stimulating hormone-\u03b2 (TSH\u03b2) genes. The observed enantioselectivity in TR expressions was consistent with that of in silico binding analysis, which suggested that (+)-S-enantiomer binds more potently to the TRs than (-)-R-enantiomer. In general, ACT enantiomers showed different influences on the secretion of THs, expression of TH-related key genes and binding affinity to TRs. Considering the different toxicity of different enantiomers, our study highlights the importance of enantioselectivity in understanding of thyroid disruption effects of chiral pesticides.",
        "keywords": [
            "Aquatic toxicity",
            "Chloroacetamide herbicide",
            "Enantiomer",
            "Thyroid disruption",
            "Zebrafish"
        ],
        "authors": [
            {
                "name": "Chao Xu",
                "org": "College of Environment, Zhejiang University of Technology, Hangzhou 310032, China. Electronic address: chaoxu@zjut.edu.cn."
            },
            {
                "name": "Xiaohui Sun",
                "org": "Zhejiang Environmental Monitoring Centre, Hangzhou 310012, China."
            },
            {
                "name": "Lili Niu",
                "org": "College of Life and Environmental Sciences, Hangzhou Normal University, 310036, China; International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Wenjing Yang",
                "org": "College of Environment, Zhejiang University of Technology, Hangzhou 310032, China."
            },
            {
                "name": "Wenqing Tu",
                "org": "College of Environment, Zhejiang University of Technology, Hangzhou 310032, China; China Research Institute of Poyang Lake, Jiangxi Academy of Sciences, Nanchang 330029, China."
            },
            {
                "name": "Liping Lu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Shuang Song",
                "org": "College of Environment, Zhejiang University of Technology, Hangzhou 310032, China."
            },
            {
                "name": "Weiping Liu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            }
        ],
        "venue": "The Science of the total environment",
        "year": 2019
    },
    "MaYvm4SY": {
        "id": "MaYvm4SY",
        "title": "Enantioselective phytotoxicity of the herbicide imazethapyr on the response of the antioxidant system and starch metabolism in Arabidopsis thaliana.",
        "abstract": "The enantiomers of a chiral compound possess different biological activities, and one of the enantiomers usually shows a higher level of toxicity. Therefore, the exploration of the causative mechanism of enantioselective toxicity is regarded as one of primary goals of biological chemistry. Imazethapyr (IM) is an acetolactate synthase (ALS)-inhibiting chiral herbicide that has been widely used in recent years with racemate. We investigated the enantioselectivity between R- and S-IM to form reactive oxygen species (ROS) and to regulate antioxidant gene transcription and enzyme activity.Dramatic differences between the enantiomers were observed: the enantiomer of R-IM powerfully induced ROS formation, yet drastically reduced antioxidant gene transcription and enzyme activity, which led to an oxidative stress. The mechanism by which IM affects carbohydrate metabolism in chloroplasts has long remained a mystery. Here we report evidence that enantioselectivity also exists in starch metabolism. The enantiomer of R-IM resulted in the accumulation of glucose, maltose and sucrose in the cytoplasm or the chloroplast and disturbed carbohydrates utilization.The study suggests that R-IM more strongly retarded plant growth than S-IM not only by acting on ALS, but also by causing an imbalance in the antioxidant system and the disturbance of carbohydrate metabolism with enantioselective manner.",
        "keywords": [
            "carbohydrate metabolism",
            "stereoisomerism",
            "structure activity relationship",
            "gene transcription",
            "starch",
            "biological activity",
            "enzyme activity"
        ],
        "authors": [
            {
                "name": "HaiFeng Qian",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Tao Lu",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "XiaoFeng Peng",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Xiao Han",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "ZhengWei Fu",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "WeiPing Liu",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            }
        ],
        "venue": "PloS one",
        "year": 2011
    },
    "1UiTFoNx": {
        "id": "1UiTFoNx",
        "title": "Drug metabolism by cytochrome p450 enzymes: what distinguishes the pathways leading to substrate hydroxylation over desaturation?",
        "abstract": "Invited for the cover of this issue are the groups of Sam\u2005P. de\u2005Visser at the University of Manchester and Weiping Liu from Zhejiang University and colleagues. The cover shows the competitive routes that can be taken to convert drug and other xenobiotic molecules in the body, and most importantly in the liver. Read the full text of the article at 10.1002/chem.201500329.",
        "keywords": [
            "oxygen atom transfer",
            "enzyme catalysis",
            "reaction mechanisms",
            "density functional calculations",
            "compound\u2005i"
        ],
        "authors": [
            {
                "name": "Ji Li",
                "org": "College of Environmental and Resource Sciences, Zhejiang University, Yuhangtang Road 866, Hangzhou 310058 (China)."
            },
            {
                "name": "Faponle Abayomi S",
                "org": "Manchester Institute of Biotechnology and School of Chemical Engineering and Analytical Science, The University of Manchester, 131 Princess Street, Manchester M1 7DN (UK)."
            },
            {
                "name": "Quesne Matthew G",
                "org": "Manchester Institute of Biotechnology and School of Chemical Engineering and Analytical Science, The University of Manchester, 131 Princess Street, Manchester M1 7DN (UK)."
            },
            {
                "name": "Sainna Mala A",
                "org": "Manchester Institute of Biotechnology and School of Chemical Engineering and Analytical Science, The University of Manchester, 131 Princess Street, Manchester M1 7DN (UK)."
            },
            {
                "name": "Zhang Jing",
                "org": "College of Environmental and Resource Sciences, Zhejiang University, Yuhangtang Road 866, Hangzhou 310058 (China)."
            },
            {
                "name": "Franke Alicja",
                "org": "Inorganic Chemistry, Department of Chemistry and Pharmacy, University of Erlangen-Nuremberg, Egerlandstrasse 1, 91058 Erlangen (Germany)."
            },
            {
                "name": "Kumar Devesh",
                "org": "Department of Applied Physics, School for Physical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Rai Bareilly Road, Lucknow 226 025 (India)."
            },
            {
                "name": "van Eldik Rudi",
                "org": "Inorganic Chemistry, Department of Chemistry and Pharmacy, University of Erlangen-Nuremberg, Egerlandstrasse 1, 91058 Erlangen (Germany)."
            },
            {
                "name": "Liu Weiping",
                "org": "College of Environmental and Resource Sciences, Zhejiang University, Yuhangtang Road 866, Hangzhou 310058 (China). wliu@zju.edu.cn."
            },
            {
                "name": "de Visser Sam P",
                "org": "Manchester Institute of Biotechnology and School of Chemical Engineering and Analytical Science, The University of Manchester, 131 Princess Street, Manchester M1 7DN (UK). sam.devisser@manchester.ac.uk."
            }
        ],
        "venue": "Chemistry (Weinheim an der Bergstrasse, Germany)",
        "year": 2015
    },
    "Pp5b1Kid": {
        "id": "Pp5b1Kid",
        "title": "Allelochemical stress causes oxidative damage and inhibition of photosynthesis in Chlorella vulgaris.",
        "abstract": "This study investigated the effects of N-phenyl-2-naphthylamine, an effective allelochemical on aquatic unicellular algae Chlorella vulgaris at physiological gene transcription level. Exposure to 2.5 mg L(-1) of N-phenyl-2-naphthylamine increased the activities of the antioxidant enzymes, superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT), which were 2.47, 3.24, and 4.27 times higher than that of the control, however, exposure to 4.0 mg L(-1) N-phenyl-2-naphthylamine decreased the activities of these antioxidant enzymes. An increase in malondialdehyde content and a decrease in chlorophyll content following exposure to N-phenyl-2-naphthylamine suggested that the alga was severely damaged and that cell growth was greatly inhibited. Electron microscopy showed that the plasma membrane was detached from the cell wall, the nucleus was condensed, and the structure of chloroplasts was disrupted, in response to N-phenyl-2-naphthylamine exposure. Real-time PCR showed that N-phenyl-2-naphthylamine reduced the transcript abundance of psaB and psbC to 3% and 1% of the control, respectively. These results demonstrated that N-phenyl-2-naphthylamine not only inhibited photosynthesis, but also triggered the synthesis of reactive oxygen species (ROS) to disrupt the subcellular structure of this aquatic organism.",
        "keywords": [
            "allelochemical",
            "n-phenyl-2-naphthylamine",
            "real-time pcr",
            "chlorella vulgaris",
            "electron microscopy"
        ],
        "authors": [
            {
                "name": "Haifeng Qian",
                "org": ""
            },
            {
                "name": "Xiaoyan Xu",
                "org": ""
            },
            {
                "name": "Wei Chen",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, People\u2019s Republic of China"
            },
            {
                "name": "Hong Jiang",
                "org": "Ministry of Education, Key Lab of Environment Remediation and Ecological Health, College of Environmental and Resource, Zhejiang University, Hangzhou 310029, People\u2019s Republic of China"
            },
            {
                "name": "Yuanxiang Jin",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, People\u2019s Republic of China"
            },
            {
                "name": "Weiping Liu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, People\u2019s Republic of China"
            },
            {
                "name": "Zhengwei Fu",
                "org": ""
            }
        ],
        "venue": "Chemosphere",
        "year": 2009
    },
    "8bBSJEPT": {
        "id": "8bBSJEPT",
        "title": "Dichlorodiphenyldichloroethylene exposure reduces r-GCS via suppressed Nrf2 in HepG2 cells: DDE EXPOSURE REDUCES R-GCS VIA SUPPRESSED NRF2 IN HEPG2 CELLS",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "meirong zhao",
                "org": ""
            },
            {
                "name": "ian p newton",
                "org": ""
            },
            {
                "name": "zhuoyu li",
                "org": ""
            },
            {
                "name": "li song",
                "org": ""
            },
            {
                "name": "xiaoting jin",
                "org": ""
            }
        ],
        "venue": "Environmental Toxicology",
        "year": 2014
    },
    "UvPaGskR": {
        "id": "UvPaGskR",
        "title": "Enantioselective interaction between plants and chiral compounds]",
        "abstract": "There exists a close relationship between plants and chiral compounds. On one hand, plants can secrete and synthesize some chiral compounds such as glucosides, enzymes, terpenoids, organic acids and phytohormones that play important roles in plant physiological and biochemical processes, and on the other hand, artificial synthetic chiral compounds, especially pesticides, had enantioselective interactions with plants. The pesticides can enantioselectively inhibit the growth of plants, or can be enantioselectively absorbed and metabolized by plants. Therefore, in the exploitation, production and application of chiral compounds, it's needed to consider the enantioselective interaction between plants and chiral compounds. In the meanwhile, choosing appropriate plants to ameliorate the environment polluted by chiral compounds is of practical significance. In this review, the enantioselective interaction between plants and chiral compounds was summarized, and the amelioration of chiral compounds-polluted environment by plants was prospected.",
        "keywords": [
            "enantioselectivity",
            "plants",
            "chiral compounds"
        ],
        "authors": [
            {
                "name": "LIU Wei-ping",
                "org": "Institute of Environmental Science,Zhejiang University,Hangzhou ,China;Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "YE Jing",
                "org": "Institute of Environmental Science,Zhejiang University,Hangzhou ,China"
            },
            {
                "name": "ZHANG An-ping",
                "org": "Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "QIAN Hai-feng",
                "org": "Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou ,China"
            }
        ],
        "venue": "Ying yong sheng tai xue bao = The journal of applied ecology / Zhongguo sheng tai xue xue hui, Zhongguo ke xue yuan Shenyang ying yong sheng tai yan jiu suo zhu ban",
        "year": 2008
    },
    "ztgNKGVI": {
        "id": "ztgNKGVI",
        "title": "Inclusion interaction of cyclodextrins and 2,4-dichlorprop methyl ester enantiomers by UV spectra.",
        "abstract": "The enantioselective inclusion interaction of various cyclodextrins(\u03b2-CD,PM-\u03b2-CD,CM-\u03b2-CD) with R/S-2,4-dichlorprop methyl ester(R/S-2,4-D) was studied by UV spectra technique.The results show that all cyclodextrins formed 1\u22361 inclusion complexes with 2,4-D,the order of binding constants of three types cyclodextrins and 2,4-D was KPM-\u03b2-CD\u25a0KCM-\u03b2-CD>K\u03b2-CD.Between 298.15 K and 318.15 K,the binding constants decreased as the temperature increased.All Gibbs free energy \u0394G,enthalpy change \u0394H,and entropy change \u0394S determined were negative,suggesting that the inclusion interaction was exothermic and spontaneously occurred by balance of enthalpy driven and entropy opposed.R-2,4-D was easier enclosed than S-2,4-D by the same kind of cyclodextrins and the order of KR/KS was accordance with the order of binding constants.",
        "keywords": [
            "2",
            "inclusion interaction",
            "cyclodextrins",
            "UV spectra",
            "4-dichlorprop methyl ester"
        ],
        "authors": [
            {
                "name": "LI Hong",
                "org": "Institute of Environmental Science,Zhejiang University,Hangzhou ,China"
            },
            {
                "name": "LIU Hui-jun",
                "org": "Institute of Environmental Science,Zhejiang University,Hangzhou ,China"
            },
            {
                "name": "WEN Yue-zhong",
                "org": "Institute of Environmental Science,Zhejiang University,Hangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Research Center of Green Chirality,College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou ,China"
            }
        ],
        "venue": "Journal of Zhejiang University(Agriculture and Life Sciences)",
        "year": 2008
    },
    "0EniTwVT": {
        "id": "0EniTwVT",
        "title": "Study on the Determination of Ciprofloxacin by the Terbium (\u2162) Ion Fluorescence Probe Sensitized by the Surfactant",
        "abstract": "The experiments indicated that terbium(\u2162) ion could complex ciprofloxacin, then emitted the characteristic fluorescence of terbium(\u2162) ion. When the surfactant of SDBS was added, the fluorescence intensity of the system was greatly increased. From this, a sensitive method of determining the ciprofloxacin was developted. The fluorescence intensity was determined by a 1 cm quartz cell with the excitation wavelength of 300 nm and the emission wavelength of 545 nm. The optimal conditions are as follows: pH 8.0-8.5, the concentration of terbium(\u2162) is 5.0\u00d7105 mol\u00b7L1, the surfactant concentration of SDBS is 8.0 \u00d7 10 4 mol\u00b7L1 . The linear range is 2.5\u00d710 6 moi\u00b7L-1-2.0\u00d710 8 mol\u00b7L1, and the detection limit (S/N = 3) is 4.0\u00d710 9 mol\u00b7L1. The presented method was applied to determine the real Pharmaceuticals of ciprofloxacin.",
        "keywords": [
            "Ciprofloxacin",
            "Terbium",
            "Determination",
            "Fluorscence probe"
        ],
        "authors": [
            {
                "name": "TONG Chang-lun",
                "org": " Institute of Environmental Science, Zhejiang University, Hangzhou , China"
            },
            {
                "name": "XIANG Guang-hong",
                "org": " Institute of Environmental Science, Zhejiang University, Hangzhou , China"
            },
            {
                "name": "LIU Wei-ping",
                "org": " Institute of Environmental Science, Zhejiang University, Hangzhou , China"
            }
        ],
        "venue": "Spectroscopy and Spectral Analysis",
        "year": 2005
    },
    "ibDoxDVE": {
        "id": "ibDoxDVE",
        "title": "Spectroscopic analysis of the interaction of ethanol and acid phosphatase from wheat germ]",
        "abstract": "Conformational and activity changes of acid phosphatase from wheat germ in ethanol solutions of different concentrations were measured by fluorescence spectra and differential UV-absorption spectra. The effect of ethanol on kinetics of acid phosphatase was determined by using the double reciprocal plot. The results indicate the ethanol has a significant effect on the activity and conformation of acid phosphatase. The activity of acid phosphatase decreased linearly with increasing the concentration of ethanol. Differential UV-absorption spectra of the enzyme denatured in ethanol solutions showed two positive peaks at 213 and 234 nm, respectively. The peaks on the differential UV-absorption spectra suggested that the conformation of enzyme molecule changed from orderly structure to out-of-order crispation. The fluorescence emission peak intensity of the enzyme gradually strengthened with increasing ethanol concentration, which is in concordance with the conformational change of the microenvironments of tyrosine and tryptophan residues. The results indicate that the expression of the enzyme activity correlates with the stability and integrity of the enzyme conformation to a great degree. Ethanol is uncompetitive inhibitor of acid phosphatase.",
        "keywords": [],
        "authors": [
            {
                "name": "Dong-mei Xu",
                "org": "Environmental Science Institute of Zhejiang University, Hangzhou 310029, China."
            },
            {
                "name": "Guang-shen Liu",
                "org": ""
            },
            {
                "name": "Li-ming Wang",
                "org": ""
            },
            {
                "name": "Wei-ping Liu",
                "org": ""
            }
        ],
        "venue": "Guang pu xue yu guang pu fen xi = Guang pu",
        "year": 2004
    },
    "sFoQX8PN": {
        "id": "sFoQX8PN",
        "title": "Immunotoxicity of pyrethroid metabolites in an in vitro model.",
        "abstract": "Risk assessment of man-made chemicals such as pesticides are mainly focused on parent compounds, and relatively little is known about their metabolites, especially with regard to target organ damages such as immunotoxicity. In the present study, the immunotoxicity of five synthetic pyrethroids (SPs) and three common metabolites was evaluated using an in vitro model by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, cytoflow, and enzyme-linked immunosorbent assay (ELISA). Cell viability and apoptosis assays showed that both SPs and their metabolites possessed cytotoxicity to the monocytic cells. The aldehyde and acid derivatives were more effective than the other compounds at cytotoxicity, with inhibition of cell viability by 56.8 and 50.6% at 10\u207b\u2075 mol L\u207b\u00b9, and induction of 8.52 and 8.81% cell apoptosis, respectively. Exposure to SPs and their metabolites also led to changes in the secretion levels of tumor necrosis factor \u03b1 (TNF \u03b1) and interleukins (ILs), and again the metabolites showed stronger effects than the parent compounds. The aldehyde derivative upregulated IL-12p70 level by 1.87-fold, and the alcohol and acid derivative increased the secretion of TNF \u03b1 5.88 and 7.96-fold, relative to the control group. In the in vitro model, the common metabolites of SPs clearly exerted greater immunotoxic effects to monocytes than the intact parent compounds. Results from the present study suggested the need for considering metabolites in achieving more comprehensive health risk assessment of man-made chemicals, including target organ toxicities such as immunotoxicity.",
        "keywords": [
            "pyrethroids",
            "cytokine",
            "cytotoxicity",
            "monocytes",
            "metabolites"
        ],
        "authors": [
            {
                "name": "Ying Zhang",
                "org": ""
            },
            {
                "name": "Meirong Zhao",
                "org": ""
            },
            {
                "name": "Meiqing Jin",
                "org": ""
            },
            {
                "name": "Chao Xu",
                "org": ""
            },
            {
                "name": "Cui Wang",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            }
        ],
        "venue": "Environmental toxicology and chemistry / SETAC",
        "year": 2010
    },
    "08oLNACQ": {
        "id": "08oLNACQ",
        "title": "Potential estrogenic effects of phosphorus-containing flame retardants.",
        "abstract": "As the substitute of polybrominated diphenyl ethers (PBDEs), further assessments about the potential ecological safety and health risks of phosphorus-containing flame retardants (PFRs) are required because the worldwide demand for PFRs has been increasing every year. In this study, we examined the agonistic/antagonistic activity of a group of PFRs by three in vitro models (luciferase reporter gene assay, yeast two-hybrid assay, and E-screen assay). Molecule docking was used to further explain the interactions between ER\u03b1 and PFRs. Data from luciferase reporter gene analysis showed three members of the nine tested PFRs significantly induced estrogenic effects, with the order of TPP > TCP > TDCPP, while TCEP and TEHP have remarkable antiestrogenic properties with calculated REC20 and RIC20 values of 10(-6) M or lower. Results from the luciferase reporter gene method are generally consistent with results obtained from the yeast two-hybrid assay and E-screen, except for the positive estrogenic activity of TBP in E-screen testing. Docking results showed that binding between ligands and ER\u03b1 was stabilized by hydrophobic interactions. As a proposed alternative for brominated flame retardant, PFRs may have anti/estrogenic activity via ER\u03b1 at the low dose typical of residue in environmental matrix or animals. PFRs with a short chain, halogen, and benzene ring in the substituent group tend to be estrogenic. Our research suggests that comprehensive evaluations, including health and ecological assessments, are required in determining whether PFRs are preferable as an emerging industrial substitute.",
        "keywords": [],
        "authors": [
            {
                "name": "Quan Zhang",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology , Hangzhou 310032, China."
            },
            {
                "name": "Meiya Lu",
                "org": ""
            },
            {
                "name": "Xiaowu Dong",
                "org": ""
            },
            {
                "name": "Cui Wang",
                "org": ""
            },
            {
                "name": "Chunlong Zhang",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Meirong Zhao",
                "org": ""
            }
        ],
        "venue": "Environmental science & technology",
        "year": 2014
    },
    "MYrkI1tg": {
        "id": "MYrkI1tg",
        "title": "Enantiomeric Resolution and Growth-Retardant Activity in Rice Seedlings of Uniconazole",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "xuemei xie",
                "org": ""
            },
            {
                "name": "jing zhang",
                "org": ""
            },
            {
                "name": "anping zhang",
                "org": ""
            },
            {
                "name": "jianqiang sun",
                "org": ""
            }
        ],
        "venue": "Journal of Agricultural and Food Chemistry",
        "year": 2012
    },
    "Dssw4TWN": {
        "id": "Dssw4TWN",
        "title": "Joint toxicity of permethrin and cypermethrin at sublethal concentrations to the embryo-larval zebrafish.",
        "abstract": "Pyrethroids, the widely used pesticides, are highly toxic to aquatic organisms. However, little information is so far available regarding the joint toxicity of type I and type II pyrethroids to fish. Zebrafish is a well-accepted aquatic vertebrate model for toxicity assessment due to small size, easy husbandry, high fecundity and transparent embryos. In this study, we utilized embryo-larval zebrafish to elucidate the combined effects of sublethal concentrations of permethrin (PM) and cypermethrin (CP), which are the most frequently used type I and type II pyrethroids, respectively. Fish were exposed from 3h postfertilization (hpf) to 144 hpf to binary mixtures of nominal concentrations of 100, 200, 300\u03bcgL(-1) PM (PM100, PM200, PM300) and 10, 20, 30\u03bcgL(-1) CP (CP10, CP20, CP30). Analytical data of the real concentrations of the chemicals showed a significant degradation of the pyrethroids but an obvious recovery after the renewal of the exposure solution. Defect rates of embryos exposed to these low concentrations of single PM or CP exhibited no statistically significant difference from the control,while the application of combination of PM and CP resulted in deleterious effects on zebrafish embryonic development. In all PM200 and PM300 exposure groups, increasing CP concentrations acted additively to the action of PM in terms of all sublethal endpoints. Co-treatment of embryos with the specific sodium channel blocker MS-222 and pyrethroids (individuals or the mixture) caused a decline in the incidences of body axis curvature and spasms compared to treatment of animals with pyrethroids alone, suggesting that the developmental toxicity of PM and CP to zebrafish was related to disruption of ion channels. We further revealed that mixture of the two pyrethroids caused greater down-regulation in the mRNA levels of proneural genes. The individual pesticides had no effect on the activity of superoxide dismutase (SOD), while the mixture exposure caused significant induction. Treatment with CP or the mixture increased the activity of catalase (CAT). Taken together, our data indicated that the mixture of PM and CP caused higher incidence of morphological defects, greater inhibition in proneural gene expression and more oxidative stress, compared to the single chemical at the corresponding doses. Our findings suggest that the combination of type I and type II pyrethroids poses a greater risk to fish in the water column.",
        "keywords": [
            "joint toxicity",
            "zebrafish",
            "pyrethroids",
            "permethrin",
            "Joint toxicity",
            "Zebrafish",
            "Permethrin",
            "Pyrethroids",
            "Cypermethrin",
            "cypermethrin"
        ],
        "authors": [
            {
                "name": "Ye Yang",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Huihui Ma",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Jinghua Zhou",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Jing Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Chemosphere",
        "year": 2014
    },
    "LSLsASWJ": {
        "id": "LSLsASWJ",
        "title": "Residues and chiral signatures of organochlorine pesticides in mollusks from the coastal regions of the Yangtze River Delta: source and health risk implication.",
        "abstract": "The residues and enantiomeric fractions of organochlorine pesticides (OCPs) were measured in 11 mollusk species collected from the coastal areas along the Yangtze River Delta to evaluate the status, potential sources, and health risks of pollution in these areas. The concentrations of DDTs, HCHs, and chlordanes ranged from 6.22 to 398.19, 0.66-7.11, and 0.14-4.08 ng g(-1) based on wet weight, respectively; DDTs and HCHs have the highest values, globally. The DDTs increased and the HCHs decreased compared to historical data. Both the box-and-whisker plots and the one-way ANOVA tests indicated that the OCP levels varied little between sampling locations and organism species. The compositions of the DDTs and HCHs suggested a cocktail input pattern of fresh and weathered technical products. The comparative EF values for the \u03b1-HCH between the sediments and mollusks, as well as the lack of any discernible difference in the relative proportions of HCH isomers among different species from the same sampling site implied that the HCH residues in the mollusks came directly from the surrounding environment. However, the biotransformation of DDTs in mollusks cannot be precluded. The assessments performed based on several available guidelines suggested that although no significant human health risks were associated with the dietary intake of OCPs, the concentrations of DDTs exceeded the maximum residual limits of China and many developed nations. Moreover, an increased lifetime cancer risk from dietary exposure to either DDTs or HCHs remains a possibility. Because non-racemic OCP residues are common in the mollusk samples, our results suggest a need to further explore the levels and toxicity of the chiral contaminants in mollusks and other foodstuff to develop the human risk assessment framework based on chiral signatures.",
        "keywords": [
            "Chlordanes",
            "DDTs",
            "Enantiomeric fraction",
            "HCHs",
            "Spatial distribution"
        ],
        "authors": [
            {
                "name": "Shanshan Zhou",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, PR China."
            },
            {
                "name": "Qiaozhi Tang",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, PR China."
            },
            {
                "name": "Meiqing Jin",
                "org": "College of Materials Science and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, PR China."
            },
            {
                "name": "Weiping Liu",
                "org": "IJRC-PTS, MOE Key Laboratory of Environmental Remediation and Ecosystem Health, Zhejiang University, Hangzhou 310058, PR China."
            },
            {
                "name": "Lili Niu",
                "org": "IJRC-PTS, MOE Key Laboratory of Environmental Remediation and Ecosystem Health, Zhejiang University, Hangzhou 310058, PR China."
            },
            {
                "name": "Hui Ye",
                "org": "Hangzhou Environmental Monitoring Centre, Hangzhou 310007, PR China."
            }
        ],
        "venue": "Chemosphere",
        "year": 2014
    },
    "5IBcrLS7": {
        "id": "5IBcrLS7",
        "title": "Enantioselective phytotoxicity of the herbicide imazethapyr and its effect on rice physiology and gene transcription.",
        "abstract": "Imazethapyr (IM) is a chiral herbicide and a widely used racemic mixture. This report investigated the enantioselectivity between R- and S-IM in rice and explored its causative mechanism at the physiological and molecular levels. The results suggested that R-IM inhibited acetolactate synthase (ALS) activity to a greater extent than S-IM, which reduced the synthesis of branched-chain amino acids (BCAAs). Additionally, most other amino acids showed enantioselectivity. On the cellular level, R-IM showed stronger toxicity against protoplasts than S-IM. A gene transcription profile analysis showed that gene transcripts in many metabolic pathways, including amino acid metabolism, photosynthesis, starch and sugar metabolism, and the tricarboxylic acid cycle displayed enantioselectivity between the IM enantiomers. R-IM regulated more genes more strongly than S-IM. This study suggested that R-IM has stronger toxicity against plants than S-IM; this toxicity is caused not only by changing targeted enzyme activity and amino acid synthesis, but also by affecting gene transcription in other metabolic pathways directly or indirectly in an enantioselective manner.",
        "keywords": [],
        "authors": [
            {
                "name": "Haifeng Qian",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Ruiqin Wang",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Haijia Hu",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Tao Lu",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Xinliang Chen",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Hanqi Ye",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Zhengwei Fu",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            }
        ],
        "venue": "Environmental science & technology",
        "year": 2011
    },
    "BgtcRCC6": {
        "id": "BgtcRCC6",
        "title": "Enantioselective phytotoxicity of the herbicide imazethapyr in rice.",
        "abstract": "Research increasingly suggests that enantiomer selectivity may be a part of the toxicological effects of chiral contaminants. In this study, we selected Japonica rice variety Xiushui 63 seedlings to evaluate the enantioselectivity of imazethapyr (IM). Significant differences in rice seedling morphology, antioxidant enzyme, oxidant marker and gene transcription were observed between the two IM enantiomers. In the seedling morphological assay, IM enantiomers inhibited elongation of primary roots and shoots, and reduced the number of adventitious roots and the density of root hairs. The inhibitory effects were enhanced with increasing concentrations of IM. The maximal root relative inhibition rate reached 80.4%, 67.0%, and 73.5% for R-(-)-IM, S-(+)-IM and racemate at the concentration of 0.5 mg L(-1), respectively, and the maximal shoot relative inhibition rate reached 77.7%, 26.9%, and 61.7%, respectively. The activities of SOD, POD and CAT and the content of MDA increased at 0.5 mg L(-1) of R-(-)-IM treatment, and were 1.8, 3.3, 1.4, and 2.2 times, respectively, over the activities S-(+)-IM. Real-time PCR showed that R-(-)-IM minimized the transcript abundance of ALS in shoot tissue to 12.2% of the S-(+)-IM, and minimized the transcript abundance of PC in seed to 9.2% of the S-(+)-IM. R-(-)-IM maximized the transcript abundance of beta-amylase in shoots to 8.6-time of the S-(+)-IM. Results from this study imply that R-(-)-IM has stronger toxicity on the growth of rice than S-(+)-IM.",
        "keywords": [
            "enantioselectivity",
            "gene transcription",
            "imazethapyr",
            "rice"
        ],
        "authors": [
            {
                "name": "Haifeng Qian",
                "org": ""
            },
            {
                "name": "Haijia Hu",
                "org": ""
            },
            {
                "name": "Yuanyuan Mao",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, People\u2019s Republic of China"
            },
            {
                "name": "Jian Ma",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, People\u2019s Republic of China"
            },
            {
                "name": "Anping Zhang",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, People\u2019s Republic of China"
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Zhengwei Fu",
                "org": ""
            }
        ],
        "venue": "Chemosphere",
        "year": 2009
    },
    "adGrw93W": {
        "id": "adGrw93W",
        "title": "A sirA-like gene, sirA2, is essential for 3-succinoyl-pyridine metabolism in the newly isolated nicotine-degrading Pseudomonas sp. HZN6 strain.",
        "abstract": "A novel nicotine-degrading Pseudomonas sp. strain, HZN6, was isolated from a pesticide-wastewater treatment facility in Hangzhou. The strain could grow on nicotine\n as its sole source of carbon, nitrogen, and energy. The strain\u2019s main intermediate metabolites were determined to be pseudooxynicotine,\n 3-succinoyl-pyridine (SP), and 6-hydroxy-3-succinoyl-pyridine (HSP). A Tn5 transposon mutant was generated in which the degradation\n pathway was blocked at the SP. A 4,583-bp DNA fragment flanking the transposon insertion site was obtained through self-formed\n adaptor PCR and analyzed. The mutant gene orfC displays 89% deduced amino acid sequence identity with the sirA-like gene (sirA2, a sulfurtransferase homologue gene) of Pseudomonas stutzeri A1501. The orfC-disrupted strain lost the ability to degrade SP, and the complementation strains with the orfC from the Pseudomonas sp. HZN6 and the sirA2 (PP_1233) from Pseudomonas putida KT2440 recovered the degradation ability. Though the orfC-disrupted strain also lost the xanthine dehydrogenase activity, the effects of tungsten on the degradation of SP and hypoxanthine\n revealed that the hydroxylation of SP to HSP was not a xanthine dehydrogenase type. These results demonstrated that the orfC gene was essential for the SP metabolism involved in the nicotine metabolic pathway in the Pseudomonas sp. HZN6 strain. This study might advance the understanding of the nicotine metabolic mechanism in Pseudomonas.",
        "keywords": [
            "degradation",
            "gene deletion",
            "3-succinoyl-pyridine",
            "sira2",
            "pseudomonas sp. hzn6",
            "nicotine",
            "Nicotine",
            "3-Succinoyl-pyridine",
            "Degradation",
            "sirA2",
            "Gene deletion",
            "Pseudomonas sp. HZN6"
        ],
        "authors": [
            {
                "name": "Jiguo Qiu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Yun Ma",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Liansheng Chen",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Lifei Wu",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Yuezhong Wen",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Applied microbiology and biotechnology",
        "year": 2011
    },
    "AijiyrpW": {
        "id": "AijiyrpW",
        "title": "Assessing the underlying breast cancer risk of Chinese females contributed by dietary intake of residual DDT from agricultural soils.",
        "abstract": "The greatest concern over DDT exposure in China arose since the early 1990s for the rising breast cancer incidence, and the cause still remains to be elucidated. An extensive survey of DDT background in agricultural soils, covered the entire region of China, was conducted. DDT at concentrations greater than 100 ng/g (the China's Farmland Environmental Quality Evaluation Standards for Edible Agricultural Products) was found to impact 42.3 million Chinese population. Considering the geographical differences with diverse DDT contributions and different diet products and habits, the average daily dietary intake was modeled and estimated to be 0.34 \u03bcg/kg p,p'-DDE (the main bioactive constituent in DDT). Population attributable fraction derived from a case-control study from 78 women with breast cancer and 72 controls was used to assess the DDT exposure risk to breast cancer. Based on the estimated population attributable fraction with a median value of 0.6% (IQR 0.23-2.11%), the excess annual breast cancer incidence rate attributable to p,p'-DDE exposure averaged 0.06\u00d710(-5) with significant spatial variations varying from 0.00021\u00d710(-5) to 11.05\u00d710(-5) in Chinese females. Exposure to DDT is a contributor to breast cancer, but the overall limited relative risk and population attributable fraction imply confounding factors for breast cancer in Chinese females. Exposure risk in a regional scale helps understand the cause and prevention of breast cancer. Our mapping and modeling method could be used to assess other environmental carcinogens and related cancer diseases.",
        "keywords": [
            "breast cancer",
            "ddt exposure",
            "dietary intake",
            "health risk"
        ],
        "authors": [
            {
                "name": "Mengling Tang",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation &amp;amp; Ecosystem Health, College of Environmental and Research Sciences, Zhejiang University, Hangzhou, China."
            },
            {
                "name": "Meirong Zhao",
                "org": "International Joint Research Center for Persistent Toxic Substances, Zhejiang University of Technology, Hangzhou, China."
            },
            {
                "name": "Shanshan Zhou",
                "org": "International Joint Research Center for Persistent Toxic Substances, Zhejiang University of Technology, Hangzhou, China."
            },
            {
                "name": "Kun Chen",
                "org": "Department of Epidemiology &amp;amp; Health Statistics, School of Public Health, Zhejiang University, Hangzhou, China."
            },
            {
                "name": "Chunlong Zhang",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation &amp;amp; Ecosystem Health, College of Environmental and Research Sciences, Zhejiang University, Hangzhou, China; Program of Environmental Science, University of Houston-Clear Lake, Houston, TX, USA."
            },
            {
                "name": "Weiping Liu",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation &amp;amp; Ecosystem Health, College of Environmental and Research Sciences, Zhejiang University, Hangzhou, China. "
            }
        ],
        "venue": "Environment international",
        "year": 2014
    },
    "6RxksXhb": {
        "id": "6RxksXhb",
        "title": "Acute toxicity difference of metolachlor and its S-isomer on earthworms",
        "abstract": "The acute lethal effect of metolachlor and its S-isomer on earthworms with the chiral difference was analyzed by using the methods of standard OECD filter paper test, artificial soil test and natural soil test. The confidence interval of filter paper toxicity test was the widest and therefore the method was not so reliable. The acute toxicity of Rac- metolachlor and S-isomer on earthworms in the natural soil test was larger than that in the artificial soil test. According to the classification criteria of the toxic chemicals, Rac-metolachlor and S-isomer should belonged to the low poisonous pesticides. There were little differences in LC50 of Rac-metolachlor and S-isomer on earthworms, which showed that the chiral difference of the two pesticides on the acute toxicity of earthworms was insignificant.",
        "keywords": [
            "Acute toxicity",
            "Difference",
            "Earthworm",
            "Metolachlor",
            "S-isomer"
        ],
        "authors": [
            {
                "name": "Dongmei Xu",
                "org": "Zhejiang Shuren University(Zhejiang Shuren University),Hangzhou,China"
            },
            {
                "name": "Xiaolu Xu",
                "org": "Zhejiang Shuren University(Zhejiang Shuren University),Hangzhou,China"
            },
            {
                "name": "Wen L. Liu",
                "org": "Environment Monitoring Station of Shanxi Province(Environment Monitoring Station of Shanxi Province,Shanxi Environment Monitoring Central Station),Taiyuan,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            }
        ],
        "venue": "Zhongguo Huanjing Kexue/China Environmental Science",
        "year": 2009
    },
    "0H1O16DC": {
        "id": "0H1O16DC",
        "title": "Probing the chiral separation mechanism and the absolute configuration of malathion, malaoxon and isomalathion enantiomers by chiral high performance liquid chromatography coupled with chiral detector-binding energy computations.",
        "abstract": "Chiral separation mechanism determination and absolute configuration assignment are fundamental to the development of chiral stationary phases (CSPs) and the evaluation of both the enantioselective bioactivity and fate of chiral compounds. This work investigated the process of chiral separation and the assignment of the absolute configurations of malathion, malaoxon, and isomalathion using chiral high performance liquid chromatography (HPLC) coupled with chiral detector-binding energy computations. Hydrogen bonding was found to be a very important factor in the chiral separation of isomalathion on Chiralpak AD, although it did not exhibit a significant effect on the chiral separation of malathion and malaoxon on Chiralcel OJ. Based on the sign of a chiral detector, the relationships between the cotton effect, optical dispersion and absolute configuration were established for individual enantiomers of malathion, malaoxon, and isomalathion. The elution orders of the enantiomers of malathion and malaoxon on Chiralcel OJ and the stereoisomers of isomalathion on Chiralpak AD predicted by binding energy computations were found to coincide precisely with those observed in the chiral separation experiments. The result suggests that binding energy computations can be used to assign the absolute configuration of the enantiomers of chiral compounds eluted on CSPs.",
        "keywords": [
            "binding energy computation",
            "absolute configuration",
            "cotton effect",
            "optical dispersion",
            "chiral separation"
        ],
        "authors": [
            {
                "name": "Anping Zhang",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Wenfeng Lai",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Jianqiang Sun",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Guixiang Hu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Journal of chromatography. A",
        "year": 2013
    },
    "9NhWBxVW": {
        "id": "9NhWBxVW",
        "title": "Environmental Toxicology IMMUNOTOXICITY OF PYRETHROID METABOLITES IN AN IN VITRO MODEL",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ying zhang",
                "org": ""
            },
            {
                "name": "meirong zhao",
                "org": ""
            },
            {
                "name": "meiqing jin",
                "org": ""
            },
            {
                "name": "chao xu",
                "org": ""
            },
            {
                "name": "cui wang",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2010
    },
    "4NgQxqz9": {
        "id": "4NgQxqz9",
        "title": "Study on the co-luminescence system of Dy\u2013Gd\u20131,6-bis(1\u2032- phenyl-3\u2032-methyl-5\u2032-pyrazol-4\u2032-one)hexanedione\u2013 cetyltrimethylammonium bromide and its analytical application",
        "abstract": "",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Changlun Tong",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Yan Zhu",
                "org": ""
            }
        ],
        "venue": "Analyst",
        "year": 2001
    },
    "Y0wWgPqP": {
        "id": "Y0wWgPqP",
        "title": "Spatial and seasonal variations in air-soil exchange, enantiomeric signatures and associated health risks of hexachlorocyclohexanes (HCHs) in a megacity Hangzhou in the Yangtze River Delta region, China.",
        "abstract": "Large amounts of hexachlorocyclohexanes (HCHs) have been historically applied in the Yangtze River Delta (YRD) region, China. Estimating the air-soil exchange of HCHs after >30years of restricted use is important for understanding their cycling in the environment. In this study, air and soil samples were concurrently collected in two seasons at agricultural and industrial sites from a megacity in the YRD region. The concentrations of HCH isomers and the enantiomeric fractions of chiral \u03b1-HCH were determined. The mean concentrations of \u2211HCHs in soils from an agricultural area (AA) and an eco-industrial park (EIP) were 1.74ng/g and 0.652ng/g, respectively, in winter, and 0.723ng/g and 0.350ng/g, respectively, in summer. The mean concentrations of \u2211HCHs in the air from the AA and the EIP were 31.2pg/m and 47.7pg/m, respectively, in winter, and 45.0pg/m and 50.0pg/m, respectively, in summer. The variations in spatial and seasonal distributions might be related to diverse geographical factors, soil properties and meteorological conditions. Source identification demonstrated that HCHs in most samples were residues from past use, which was further evidenced by the enantiomeric signatures of chiral \u03b1-HCH. A preferential degradation of (-)-\u03b1-HCH was showed in soils and summer air, while a preferential depletion of (+)-\u03b1-HCH was displayed in winter air. The values of the fugacity fraction (ff) of HCHs suggest a net volatilization from soils to air, but long-range transport may also partly contribute to the atmospheric HCHs according to the results from enantiomeric analysis. The human health risk assessments indicated an absence of noncarcinogenic risks and very low carcinogenic risks for HCHs in both soils and air to human health. Results from this study provide valuable data for assessing the fate and health risks of HCHs in the YRD region.",
        "keywords": [
            "Air-soil exchange",
            "Enantiomeric signature",
            "HCH",
            "Human health risk",
            "Spatial and seasonal distribution"
        ],
        "authors": [
            {
                "name": "Siyu Zhu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), Institute of Environmental Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Lili Niu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), Institute of Environmental Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China; Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: niulili@zju.edu.cn."
            },
            {
                "name": "Muhammad Aamir",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), Institute of Environmental Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Yuting Zhou",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), Institute of Environmental Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Chao Xu",
                "org": "College of Environment, Zhejiang University of Technology, Hangzhou 310032, China."
            },
            {
                "name": "Weiping Liu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), Institute of Environmental Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China; Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: wliu@zju.edu.cn."
            }
        ],
        "venue": "The Science of the total environment",
        "year": 2017
    },
    "YjbhkhJ0": {
        "id": "YjbhkhJ0",
        "title": "Enantioseparation and Study of Thermodynamical Property of Chiral Pesticdes by HPLC",
        "abstract": "Chiral separation of O,O-dimethyl-1-(3-trifluoromrthylphenoxyacetoxy) ethylphosphonate enantiomers by high performance liquid chromatography(HPLC) has been studied. The effect of chromatographic conditions such as stationary phases, flow rate, alcohols modifier in the mobile phases, added amounts of isopropanol in the mobile phases, column temperature to recognition of the O,O-dimethyl-1-(3-trifluoromrthylphenoxyacetoxy) ethylphosphonate using chiral high-performance liquid chromatography were considered, the thermodynamical mecha- nism of enantioseparation have also been preliminary discussed.",
        "keywords": [
            "HPLC",
            "O-dimethyl-1-(3-trifluoromrthylphenoxyacetoxy)ethylphosphonate",
            "thermodynamical",
            "enantiomers",
            "O"
        ],
        "authors": [
            {
                "name": "HU Jian-hua",
                "org": "Hangzhou Wanxiang Polytechnic, Hangzhou , China;Research Center of Environmental Science, Zhejiang University of Technology, Hangzhou , China"
            },
            {
                "name": "YAO Hua-zhen",
                "org": "Hangzhou Wanxiang Polytechnic, Hangzhou , China;Research Center of Environmental Science, Zhejiang University of Technology, Hangzhou , China"
            },
            {
                "name": "ZHOU Shan-shan",
                "org": "Institute of Environmental Science, Zhejiang University, Hangzhou , China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Research Center of Environmental Science, Zhejiang University of Technology, Hangzhou , China"
            }
        ],
        "venue": "Agrochemicals",
        "year": 2008
    },
    "F37hxRGx": {
        "id": "F37hxRGx",
        "title": "Effects of metolachlor on biological activities in celery rhizophere and non-rhizosphere soil",
        "abstract": "The study with rhizobag showed that in celery rhizophere and non-rhizosphere soil, metolachlor had a certain inhibitory effect on catalase activity, but stimulated dehydrogenase activity. Generally, the enzyme activities in rhizosphere soil were higher than those in non-rhizosphere soil. After 45 days of metolachlor treatment, the numbers of bacteria and fungi in rhizosphere soil were higher than those in non-rhizosphere soil, and the R/S was 1.76 to approximately 2. 51. The numbers of actinomycetes were relatively stable, and the rhizosphere effect was not significant. The degradation rate of metolachlor in rhizosphere and nonrhizosphere soil was 0. 0217 and 0.0176, and the corresponding half-live was 31.9 and 39.4 days, respectively. The degradation of metolachlor was enhanced greatly in rhizosphere soil.",
        "keywords": [
            "Catalase",
            "Celery rhizosphere",
            "Dehydrogenase",
            "Metolachlor",
            "Soil microorganism"
        ],
        "authors": [
            {
                "name": "Bo Chen",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Dongmei Xu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "GuangShen Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Ying yong sheng tai xue bao = The journal of applied ecology / Zhongguo sheng tai xue xue hui, Zhongguo ke xue yuan Shenyang ying yong sheng tai yan jiu suo zhu ban",
        "year": 2006
    },
    "tI3TbH8S": {
        "id": "tI3TbH8S",
        "title": "Exposure to organochlorine pollutants and type 2 diabetes: a systematic review and meta-analysis.",
        "abstract": "Though exposure to organochlorine pollutants (OCPs) is considered a risk factor for type 2 diabetes (T2DM), epidemiological evidence for the association remains controversial. A systematic review and meta-analysis was applied to quantitatively evaluate the association between exposure to OCPs and incidence of T2DM and pool the inconsistent evidence.Publications in English were searched in MEDLINE and WEB OF SCIENCE databases and related reference lists up to August 2013. Quantitative estimates and information regarding study characteristics were extracted from 23 original studies. Quality assessments of external validity, bias, exposure measurement and confounding were performed, and subgroup analyses were conducted to examine the heterogeneity sources.We retrieved 23 eligible articles to conduct this meta-analysis. OR (odds ratio) or RR (risk ratio) estimates in each subgroup were discussed, and the strong associations were observed in PCB-153 (OR, 1.52; 95% CI, 1.19-1.94), PCBs (OR, 2.14; 95% CI, 1.53-2.99), and p,p'-DDE (OR, 1.33; 95% CI, 1.15-1.54) based on a random-effects model.This meta-analysis provides quantitative evidence supporting the conclusion that exposure to organochlorine pollutants is associated with an increased risk of incidence of T2DM.",
        "keywords": [
            "systematic reviews",
            "biomedical research",
            "biomarkers",
            "pollutants",
            "bioinformatics",
            "meta analysis",
            "cross sectional studies",
            "diabetes mellitus"
        ],
        "authors": [
            {
                "name": "Mengling Tang",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China."
            },
            {
                "name": "Kun Chen",
                "org": "Department of Epidemiology &amp; Health Statistics, School of Public Health, Zhejiang University, Hangzhou, China."
            },
            {
                "name": "Fangxing Yang",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China."
            },
            {
                "name": "Weiping Liu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China."
            }
        ],
        "venue": "PloS one",
        "year": 2014
    },
    "njbvzHn3": {
        "id": "njbvzHn3",
        "title": "Enantioselectivity Tuning of Chiral Herbicide Dichlorprop by Copper: Roles of Reactive Oxygen Species",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "chensi shen",
                "org": ""
            },
            {
                "name": "meirong zhao",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "yuezhong wen",
                "org": ""
            },
            {
                "name": "hui chen",
                "org": ""
            }
        ],
        "venue": "Environmental Science & Technology",
        "year": 2011
    },
    "7dSXLqfc": {
        "id": "7dSXLqfc",
        "title": "Risk assessment of xenoestrogens in a typical domestic sewage-holding lake in China.",
        "abstract": "Release of domestic sewage leads to accumulation of xenoestrogens in holding waters, especially in closed or semi-enclosed waters such as lakes. In the study, the occurrence, distribution, estrogenic activity and risk of eight xenoestreogens were evaluated in Lake Donghu, China. Nonylphenol (NP), octylphenol (OP), and bisphenol A (BPA) were identified as the main xenoestrogens ranging from tens of ngL(-1) (in the surface water) or ng g(-1)dw (in the suspended particles and sediment) to tens of \u03bcgL(-1) or \u03bcg g(-1)dw. The sum of 17\u03b2-estradiol equivalents (\u2211EEQs) ranged from 0.32 to 45.02 ngL(-1) in the surface water, 0.53 to 71.86 ng g(-1)dw in the suspended particles, and 0.09 to 24.73 ng g(-1)dw in the sediment. Diethylstilbestrol (DES) was determined as the main contributor to \u2211EEQs followed by NP. The risk assessment showed a higher risk in the surface water than in the suspended particles and sediment in such domestic sewage-holding lake.",
        "keywords": [
            "suspended particles",
            "DES",
            "Suspended particles",
            "EEF",
            "nonylphenol",
            "bisphenol A",
            "risk quotient",
            "17\u03b1-ethinylestradiol",
            "Risk assessment",
            "estriol",
            "Surface water",
            "E3",
            "BPA",
            "sediment",
            "diethylstilbestrol",
            "17\u03b2-Estradiol equivalent",
            "surface water",
            "NP",
            "17\u03b2-estradiol equivalent",
            "E2",
            "OP",
            "predicted no effect concentration",
            "MSTFA",
            "E1",
            "xenoestrogens",
            "17\u03b2-estradiol",
            "EE2",
            "total organic carbon",
            "risk assessment",
            "17\u03b2-estradiol equivalency factor",
            "estrone",
            "Xenoestrogens",
            "PNEC",
            "TOC",
            "N-methyl-N-trimethylsilyl trifluoroacetamide",
            "EEQ",
            "RQ",
            "Sediment",
            "octylphenol"
        ],
        "authors": [
            {
                "name": "Shiwei Jin",
                "org": "Wuhan Institute of Technology(Wuhan Institute of Technology,Wuhan Institute of Chemical Technology,Wuhan Inst. of Chemical Technology),Wuhan,China"
            },
            {
                "name": "Fangxing Yang",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Ying Xu",
                "org": "Institute of Hydrobiology, Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Hydrobiology),Wuhan,China"
            },
            {
                "name": "Heping Dai",
                "org": "Institute of Hydrobiology, Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Hydrobiology),Wuhan,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Chemosphere",
        "year": 2013
    },
    "1gR0Tkxp": {
        "id": "1gR0Tkxp",
        "title": "\u03b3-Al2O3 modified with praseodymium: An application in the heterogeneous catalytic ozonation of succinic acid in aqueous solution",
        "abstract": "In an attempt to utilize ozone effectively, a series of praseodymium-modified \u03b3-Al2O3 (Pr/Al 2O3) was prepared via incipient wetness impregnation using Pr(NO3)3\u00b76H2O as the precursor. The structure and properties of the catalysts were studied by X-ray diffraction (XRD) and the Brunauer-Emmett-Teller (BET) method. Catalytic activity was evaluated by monitoring the degradation of succinic acid (SA) in the presence of ozone. The praseodymium modification can effectively enhance the ozonation activity of \u03b3-Al2O3 upon SA removal. Increasing the calcination temperature of Pr/Al2O3 is disadvantageous for the catalytic process, whereas increasing the load of praseodymium is helpful. After three successive cycles, the Pr/Al2O3 catalyst remained stable in the catalytic ozonation of SA. Overall, the initial degradation rate of SA, as well as the saturated adsorption capacity of SA, were found to have a linear relation to changes of the surface hydroxyl groups of the catalyst. On this basis, we conclude that the significant enhancement of SA degradation using Pr/Al2O3 as a catalyst should be because praseodymium, in the form of Pr6O11, promoted the formation of surface hydroxyl groups. Hence, the adsorption was increased, and the degradation rate of SA was enhanced. \u00a9 2010 American Chemical Society.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Zhiqiao He",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Angliang Zhang",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Shuang Song",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Zhiwu Liu",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Jianmeng Chen",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Xinhua Xu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Industrial and Engineering Chemistry Research",
        "year": 2010
    },
    "xAuy0kDO": {
        "id": "xAuy0kDO",
        "title": "STUDY ON ELECTRO-CATALYTIC OXIDATION OF 4-NITROPHENOL BY LA-DOPED SNO_2/TI PROCESS",
        "abstract": "The La-doped SnO2/Ti poles were prepared by sol-gel process.Factors on the removal rate were investigated,such as voltaic density\u3001interelectrode distance,pH,chlorine etc.At the optimal conditions of voltaic density 20 mA\u00b7cm-2,interelectrode distance 2 cm,pH 1,chlorine 60 mg\u00b7L-1,electrolysis time 3 h,the removal rate of 4-nitrophenol can reach 97.69%.And the middle outcome of the treatment is studied with HPLC.",
        "keywords": [
            "electric catalytic",
            "Ti/SnO2(La) anode",
            "4-nitrophenol",
            "electrolysis"
        ],
        "authors": [
            {
                "name": "HUANG Xin-wen",
                "org": "College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "LIU Chun-qian",
                "org": "College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "LU Xiao-qin",
                "org": "College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou ,China"
            }
        ],
        "venue": "Technology of Water Treatment",
        "year": 2008
    },
    "2mIfY4HT": {
        "id": "2mIfY4HT",
        "title": "Effects of metolachlor on transcription of thyroid system-related genes in juvenile and adult Japanese medaka (Oryzias latipes).",
        "abstract": "Metolachlor (MT) is one of the most important pesticides applied to corn and other crops for controlling broadleaf and grass weeds. However, the effects of MT on the thyroid system in fish remain to be elucidated. In the present experiment, transcription of genes related to the thyroid system, including thyrotropin releasing hormone (Trh), deiodinase 2 (Dio2), thyroid hormone receptor \u03b1 (Thr\u03b1), and thyroid hormone receptor \u03b2 (Thr\u03b2), were induced by MT in a sex-, developmental stage-, and tissue- specific manner when medaka were exposed to various concentrations of MT for 14 days. The transcriptional levels of the genes were only significantly altered in both juvenile and adult female medaka in response to MT exposure. And the lowest concentrations able to significantly induce transcription of the selected genes were 10 and 100 \u03bcg/L in juvenile and adult female medaka, respectively. In adult female medaka, a significant up-regulation of these genes was detected only in the brain, with little or no effect in the liver. Furthermore, MT-induced (100 \u03bcg/L) transcription of thyroid system-related genes was enhanced significantly in male juvenile medaka in the presence of estrogen (E2) (50 and 100 ng/L). Moreover, the mRNA levels of Thr\u03b1 and Thr\u03b2 in males increase with the combined treatments of 100 \u03bcg/L MT and 100 ng/L E2. Dio2 increased when exposed to 100 \u03bcg/L MT and 50 or 100 ng/L E2. The information obtained in the present study suggests that MT has the potential to influence several steps of the hypothalamus-pituitary-thyroid (HPT) axis homeostasis and to disrupt the thyroid system in medaka.",
        "keywords": [
            "medaka",
            "metolachlor",
            "real-time rt-pcr",
            "thyroid system",
            "thyroid hormone receptor"
        ],
        "authors": [
            {
                "name": "Yuanxiang Jin",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Rujia Chen",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Linggang Wang",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Jingwen Liu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Yuefeng Yang",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Cheng Zhou",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Weiping Liu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Zhengwei Fu",
                "org": ""
            }
        ],
        "venue": "General and comparative endocrinology",
        "year": 2011
    },
    "TnuOx07o": {
        "id": "TnuOx07o",
        "title": "Particle size-specific distributions and preliminary exposure assessments of organophosphate flame retardants in office air particulate matter.",
        "abstract": "In this study, the concentrations, size-specific distributions, and preliminary exposure assessments of 10 organophosphate flame retardants (OPFRs) were investigated in suspended particulate matter collected from offices. OPFRs were detected in a range of 5.00-147.77 ng/m(3). Tri(chloropropyl) phosphate (TCPP) was the most abundant analog followed by tri(2-chloroethyl) phosphate (TCEP) and triphenyl phosphate (TPhP). Chlorinated OPFRs (TCPP, TCEP, and tris(1,3-dichloroisopropyl) phosphate (TDCPP)) contributed to about 77% of the total OPFRs. Size-specific distributions revealed that TCEP, tri-n-propyl phosphate (TnPP), TCPP, and tri-n-butyl phosphate (TnBP) shared a similar distribution pattern with a peak in the fraction 4.7-5.8 \u03bcm. A peak was also found in the distributions of tricresyl phosphate (TCrP), 2-ethylhexyl diphenyl phosphate (EHDPP), and tri(2-ethylhexyl) phosphate (TEHP) but in different fractions. A bimodal distribution was observed for TDCPP, TPhP, and tributoxyethyl phosphate (TBEP). The results of mass median aerodynamic diameter (MMAD) indicated that TDCPP, TCrP, and TEHP were mainly located on ultrafine particles (\u22641 \u03bcm), while TnPP, TBEP, and EHDPP mainly on fine particles (\u22642.5 \u03bcm). Furthermore, MMADs of OPFRs were found to be positively correlated with their vapor pressures (Vp) (p < 0.01), indicating that OPFR analogs with low Vp were inclined to adsorb on small size particles. Preliminary exposure assessments suggested a low risk of exposure to OPFRs for people working in such offices, and inhaled OPFRs would mainly deposit in the head region of the respiratory tract.",
        "keywords": [],
        "authors": [
            {
                "name": "Fangxing Yang",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Jinjian Ding",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Wei Huang",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Wei Xie",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Environmental science & technology",
        "year": 2014
    },
    "4g97y2uV": {
        "id": "4g97y2uV",
        "title": "New insights into the effects of the herbicide imazethapyr on Cu(II) ecotoxicity to the aquatic unicellular alga Scenedesmus obliquus.",
        "abstract": "Interactions between heavy metals and organic contaminants can result in speciation changes of heavy metals. Therefore, it is unknown whether organic contaminants in aquatic environments act as selective agents to mediate the toxicity of heavy metals. To elucidate these interactions, the effects of the herbicide imazethapyr (IM) on Cu(II) ecotoxicity to the aquatic unicellular alga Scenedesmus obliquus were investigated. It was found that the toxicity of Cu could be mediated by IM. To explore the mechanisms involved, complex formation, the catalytic activity of the complex, the Cu species and the distribution of Cu and Fe in the algal cell were characterized. The results showed that Cu(II) and IM formed an octahedral complex with an IM:Cu molar ratio of 2:1. These complexes also catalyzed the disproportionation of hydrogen peroxide. Analysis of the K-edge of Cu using XAFS spectroscopy indicated that when treated with Cu, the Cu was bound to polygalacturonic acid (on the cell wall), and once inside the cell, Cu may complex with the reduced glutathione (GSH) (in the cell). When the cell is treated with IM and Cu simultaneously, IM-Cu may be the primary complex formed. Once Cu combines with IM, it is difficult for it to interact with the cell wall. In addition, using scanning transmission soft X-ray microscopy, it was found that Cu could induce changes in the distribution of the essential trace element Fe, whereas IM-Cu cannot. This finding demonstrates the importance of interactions between heavy metals and organic contaminants, which are able to mediate the toxicity of heavy metals and should be considered in future risk assessments.",
        "keywords": [
            "speciation",
            "herbicides",
            "green algae",
            "copper toxicity"
        ],
        "authors": [
            {
                "name": "Hui Chen",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Xiaolin Sheng",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Yuezhong Wen",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Lijuan Zhang",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "Hongliang Bao",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "Lina Li",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Aquatic toxicology (Amsterdam, Netherlands)",
        "year": 2013
    },
    "mI2RuWop": {
        "id": "mI2RuWop",
        "title": "Study on reproductive toxicity in female mammals of xenoestrogenic pesticides",
        "abstract": "Some pesticides may interfere with the female mammal hormonal function,which may lead to negative effects on the reproductive system through disruption of the hormonal balance necessary for proper functioning.The purpose of this review is to give an overview of the various ways in which xenoestrogenic pesticides may disrupt the female reproductive system,including hormone regulation,reproductive organs and embryo development.What's more,the molecular mechanisms are described for effects of pesticide exposure in vitro and on experimental animals in vivo.Most of xenoestrogenic pesticides are chiral pesticides,the structure of pesticides effects mammals reproduction also was introduction.",
        "keywords": [
            "chiral pesticides",
            "xenoestrogens",
            "female mammal",
            "reproductive toxicity"
        ],
        "authors": [
            {
                "name": "YANG Cai-xia",
                "org": "Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "PAN Zhi-yan",
                "org": "Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "ZHAO Mei-rong",
                "org": "Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "WANG Lu-mei",
                "org": "Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou ,China"
            }
        ],
        "venue": "Journal of Zhejiang University of Technology",
        "year": 2008
    },
    "r7Mewi8r": {
        "id": "r7Mewi8r",
        "title": "Metabolism of halogenated alkanes by cytochrome P450 enzymes. Aerobic oxidation versus anaerobic reduction.",
        "abstract": "The cytochromes P450 are a large class of heme-containing enzymes that catalyze a broad range of chemical reactions in biosystems, mainly through oxygen-atom transfer to substrates. A relatively unknown reaction catalyzed by the P450s, but very important for human health, is the activation of halogenated substrates, which may lead to toxicity problems. However, its catalytic mechanism is currently unknown and, therefore, we performed a detailed computational study. To gain insight into the metabolism of halogenated compounds by P450 enzymes, we have investigated the oxidative and reductive P450-mediated activation of tetra- and trichloromethane as halogenated models with density functional theory (DFT) methods. We propose an oxidative halosylation mechanism for CCl4 under aerobic conditions by Compound\u2005I of P450, which follows the typical Groves-type rebound mechanism. By contrast, the metabolism of CHCl3 occurs preferentially via an initial hydrogen-atom abstraction rather than halosylation. Kinetic isotope effect studies should, therefore, be able to distinguish the mechanistic pathways of CCl4 versus CHCl3 . We find a novel mechanism that is different from the well accepted P450 substrate activation mechanisms reported previously. Moreover, the studies highlight the substrate specific activation pathways by P450 enzymes leading to different products. These reactivity differences are rationalized using Marcus theory equations, which reproduce experimental product distributions.",
        "keywords": [
            "cytochromes",
            "density functional calculations",
            "halogenated substrates",
            "oxidative",
            "reductive"
        ],
        "authors": [
            {
                "name": "Li Ji",
                "org": "MOE Key Lab of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058 (China)."
            },
            {
                "name": "Jing Zhang",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Sam P de Visser",
                "org": ""
            }
        ],
        "venue": "Chemistry, an Asian journal",
        "year": 2014
    },
    "OksMV1ph": {
        "id": "OksMV1ph",
        "title": "Assessing pesticide contamination with earthworm biomarkers",
        "abstract": "Increasing attention was paid to the problem of pesticide pollution by people. Risk assessment of pesticide should not be only based on the chemical analysis of environmental samples,since this method could't truly distinguish whether the pesticide was harmful to environment. Thus,biological assessment system should be established. Earthworms were widely used to evaluate the pesticide pollution owing to its large number in soil ecosystem and its role as the bottom of food chain. The changes of earthworm biomarkers measured at the molecular or cellular level could be used to discern agricultural chemical pollution at earlier time. Based on the history of biomarker,earthworm could be used as the model organism to evaluate the soil ecological risk of pesticides. According to this characteristic of earthworm,some kinds of earthworm biomarker (such as acetylcholinesterase,antioxidant enzymes,immunocyte and gene expression) were discussed on its assessment of the pesticide contamination level and its action mechanism.",
        "keywords": [
            "earthworm",
            "pesticide contamination",
            "biomarkers"
        ],
        "authors": [
            {
                "name": "CHEN Lin-hua",
                "org": "Research Center of Environment Science,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "JIANG Ji-hong",
                "org": "Research Center of Environment Science,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "YANG Zheng-jian",
                "org": "Institute of Environmental Protection in Xiaoshan District,Hangzhou ,China"
            },
            {
                "name": "MA Yun",
                "org": "Research Center of Environment Science,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Research Center of Environment Science,Zhejiang University of Technology,Hangzhou ,China"
            }
        ],
        "venue": "Acta Agriculturae Zhejiangensis",
        "year": 2010
    },
    "v1crjjYE": {
        "id": "v1crjjYE",
        "title": "Occurrence of phthalate esters in sediments in Qiantang River, China and inference with urbanization and river flow regime.",
        "abstract": "Phthalate esters (PAEs), a group of emerging organic contaminants, have become a serious issue arousing much attention for their ubiquitous presence and hazardous impact on the environment. This study provides the first data on distribution of PAEs in the sediments in the Qiantang River, Zhejiang Province, China, and the inference with urbanization and river flow regime. PAEs were detected in all 23 sediment samples analyzed, and the total concentrations of their 16 congeners in sediments ranged from 0.59 to 6.74\u03bcg/g dry weight (dw), with the geometric mean value of 2.03\u03bcg/g dw. Of the 16 PAE congeners, di-n-butyl phthalate (DnBP), diisobutyl phthalate (DiBP), and di(2-ethylhexyl) phthalate (DEHP) were present in all sediment samples. The PAEs concentrations in urban regions were higher than those in rural regions because of higher discharge of PAEs from plastic materials in urbanized areas. Concentrations of PAEs were positively correlated with sediment organic matter (fOM) and negatively correlated with logistic value of annual average flow volume at sample sites. River flow regime modified by man-made dams significantly affected the distribution of PAEs. Analysis of congener composition of PAEs indicated that the DEHP was predominant congener in the Qiantang River. The normalized concentration of DEHP exceeded recommended environmental risk limit (ERL).",
        "keywords": [
            "spatial distribution",
            "sediment",
            "risk assessment",
            "phthalate esters",
            "the qiantang river"
        ],
        "authors": [
            {
                "name": "Jianqiang Sun",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Jing Huang",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Anping Zhang",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Wenwei Cheng",
                "org": "Hangzhou Tea Research Institute(Hangzhou Tea Research Institute),Hangzhou,China"
            }
        ],
        "venue": "Journal of hazardous materials",
        "year": 2013
    },
    "t377ik5X": {
        "id": "t377ik5X",
        "title": "Separation and aquatic toxicity of enantiomers of the pyrethroid insecticide lambda-cyhalothrin.",
        "abstract": "Chiral pollutants are receiving growing environmental concern due to differential biological activities of their enantiomers. In the present study, enantiomeric separation of the pyrethroid insecticide lambda-cyhalothrin (LCT) was investigated by high-performance liquid chromatography (HPLC) using the columns of Chiralpak AD (amylase tris[3,5-dimethyl-phenyl carbamate]), Chiralpak AS (amylase tris[(S)-1-phenyl carbamate]), Chiralcel OD (cellulose tris[3,5-dimethylphenyl carbamate]), and Chiralcel OJ (cellulose tris[4-methyl benzoate]) with different chiral stationary phases. The differential toxicities of the enantiomers in aquatic systems were evaluated using the acute zebrafish (Danio rerio) toxicity test and the zebrafish embryo test. The enantiomers of LCT were separated completely on all the columns tested and detected by circular dichroism at 236 nm. Better separations were achieved at lower temperatures (e.g., 20 degrees C) and lower levels of polar modifiers (</=5%) in mobile phase. Ethanol was found to be a good modifier of the mobile phase for all the columns, although isopropanol acted better for the Chiralcel OD column. The (-)-enantiomer was >162 times more toxic than its antipode to zebrafish in the acute test. The embryo test indicated that the exposure to LCT enantioselectively induced crooked body, yolk sac edema, and pericardial edema and that the (-)-enantiomer was 7.2 times stronger than the (+)-enantiomer in 96-h mortality. The malformations were induced by the racemate and its (-)-enantiomer at lower concentrations tested (e.g., 50 microg L(-1)), whereas the (+)-enantiomer induced malformations at relatively higher concentrations (>/=100 microg L(-1)). These results suggest that the toxicological effects of chiral pesticides must be evaluated using their individual enantiomers.",
        "keywords": [
            "toxicity",
            "enantioselective",
            "zebrafish embryo",
            "lambda-cyhalothrin",
            "high-performance liquid chromatographic separation"
        ],
        "authors": [
            {
                "name": "Chao Xu",
                "org": ""
            },
            {
                "name": "Jiajia Wang",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "G Daniel Sheng",
                "org": ""
            },
            {
                "name": "Yunjie Tu",
                "org": ""
            },
            {
                "name": "Yun Ma",
                "org": ""
            }
        ],
        "venue": "Environmental toxicology and chemistry / SETAC",
        "year": 2008
    },
    "9URdb087": {
        "id": "9URdb087",
        "title": "Enantioselective degradation and ecotoxicity of the chiral herbicide diclofop in three freshwater alga cultures.",
        "abstract": "Aryloxyphenoxypropanoates are a class of chiral herbicides. They have a pair of enantiomers, only the R(+) form of which is herbicidally active. Diclofop, the model compound of these herbicides, is commercialized as the racemate of the ester form, diclofop-methyl, consisting of a 1:1 mixture of the enantiomers. This study evaluated the enantioselectivity in aquatic toxicity and biodegradation of diclofop and diclofop-methyl. The herbicidally inactive S(-) enantiomers of both diclofop-methyl and diclofop were similar to or higher than the corresponding R(+) forms in toxicity to algae, depending on specific species. Although no enantiomeric conversion occurred for diclofop-methyl and diclofop, the difference in the enantioselective degradation of these herbicides observed in algae cultures suggested that their application forms were an important factor determining their enantioselective environmental behavior. The cell permeability and heat treatment of algae revealed that the enantioselective degradation of diclofop in algae cultures was governed primarily by the facilitated uptake by algae, whereas the enantioselective toxicity was primarily governed by the passive uptake. These results suggested that the acute toxicity test such as the 96 h EC 50 was insufficient to assess the ecological risk of chiral pesticides because of the differential degradation as well as possibly differential action sites of enantiomers. From this study, it was concluded that the enantioselective degradation and toxicity of chiral herbicides may result in their ecotoxicological effects being difficult to predict and that specific attention should thus be paid to currently used racemic pesticides as less active or inactive enantiomers may pose higher ecological risks.",
        "keywords": [
            "degradation",
            "diclofop",
            "enantioselectivity",
            "freshwater alga"
        ],
        "authors": [
            {
                "name": "Xiyun Cai",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Guangyao Sheng",
                "org": ""
            }
        ],
        "venue": "Journal of agricultural and food chemistry",
        "year": 2008
    },
    "6AgFkNLq": {
        "id": "6AgFkNLq",
        "title": "Cypermethrin has the potential to induce hepatic oxidative stress, DNA damage and apoptosis in adult zebrafish (Danio rerio).",
        "abstract": "Cypermethrin (CYP), a widely used Type II pyrethroid pesticide, is one of the most common contaminants in the freshwater aquatic system. We studied the effects of CYP exposure on the induction of hepatic oxidative stress, DNA damage and the alteration of gene expression related to apoptosis in adult zebrafish. Hepatic mRNA levels for the genes encoding antioxidant proteins, such as Cu/Zn-Sod, Mn-Sod, Cat, and Gpx, were significantly upregulated when zebrafish were exposed to various concentrations of CYP for 4 or 8 days. In addition, the main genes related to fatty acid \u03b2-oxidation and the mitochondrial genes related to respiration and ATP synthesis were also significantly upregulated after exposure to high concentrations (1 and 3 \u03bcg L(-1)) of CYP for 4 or 8 days. Moreover, in a comet assay of zebrafish hepatocytes, tail DNA, tail length, tail moment and Olive tail moment increased in a concentration-dependent manner. The significant induction (p<0.01) of all four parameters observed with CYP concentrations of 0.3 \u03bcg L(-1) or higher suggests that heavy DNA damage was induced even at low levels. Furthermore, several apoptosis- related genes, such as p53, Apaf1 and Cas3, were significantly upregulated after CYP exposure, and Bcl2/Bax expression ratio decreased, especially in groups treated with 1 and 3 \u03bcg L(-1) CYP for 8 days. Taken together, our results suggested that CYP has the potential to induce hepatic oxidative stress, DNA damage and apoptosis in zebrafish. This information will be helpful in fully understanding the mechanism of aquatic toxicology induced by CYP in fish.",
        "keywords": [
            "apoptosis",
            "zebrafish",
            "dna damage",
            "oxidative stress",
            "gene transcription",
            "cypermethrin"
        ],
        "authors": [
            {
                "name": "Yuanxiang Jin",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Shanshan Zheng",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Yue Pu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Linjun Shu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Liwei Sun",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Weiping Liu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Zhengwei Fu",
                "org": ""
            }
        ],
        "venue": "Chemosphere",
        "year": 2011
    },
    "8zgVWYN4": {
        "id": "8zgVWYN4",
        "title": "Residues of currently and never used organochlorine pesticides in agricultural soils from Zhejiang Province, China.",
        "abstract": "Studies on residues of currently and never used organochlorine pesticides (OCPs) facilitate the assessment of the contamination level, distribution, sources, transportation, and trend of these selected OCPs in China. In this work we investigated the concentration levels of endosulfans and chlordane, which are currently used, and the never used aldrin and dieldrin in the province of Zhejiang, a rainy, and hilly tea-growing province in eastern China. The average/mean residue levels of OCPs was in the order \u2211endosulfan > \u2211chlordane > aldrin > dieldrin. The residue level was in good agreement with the usage of OCPs in Zhejiang. The spatial distribution showed that the residues of OCPs in soils from the mountain area were always higher than those in soils from the plains. The distribution characteristics were related to usage for current-use OCPs and temperature for never used OCPs. The isomeric ratios and enantiomeric fractions are useful tools to identify the degradation preference of contaminants. The wide range of ratios between trans-chlordane (TC) and cis-chlordane (CC) indicated that the degradation of the two isomers of chlordane was different at different sites. Nonracemic residues of TC and CC were observed in most soils; this is significant since the enantiomers have different toxicities.",
        "keywords": [],
        "authors": [
            {
                "name": "Anping Zhang",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), Zhejiang University of Technology, Hangzhou 310014, China."
            },
            {
                "name": "Li Fang",
                "org": ""
            },
            {
                "name": "Junliang Wang",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Hejin Yuan",
                "org": ""
            },
            {
                "name": "Liisa Jantunen",
                "org": ""
            },
            {
                "name": "Yi-Fan Li",
                "org": ""
            }
        ],
        "venue": "Journal of agricultural and food chemistry",
        "year": 2012
    },
    "sah0nPcw": {
        "id": "sah0nPcw",
        "title": "Enantioselective Phytotoxicity of Dichlorprop to Arabidopsis thaliana: The Effect of Cytochrome P450 Enzymes and the Role of Fe.",
        "abstract": "The ecotoxicology effects of chiral herbicides have long been recognized and have drawn increasing attention. The toxic mechanisms of herbicides in plants are involved in production of reactive oxygen species (ROS) and cause damage to target enzymes, but the relationship between these two factors in the enantioselectivity of chiral herbicides has rarely been investigated. Furthermore, even though cytochromes P450 enzymes (CYP450s) have been related to the phytotoxicity of herbicides, their roles in the enantioselectivity of chiral herbicides have yet to be explored. To solve this puzzle, the CYP450s suicide inhibitor 1-aminobenzotriazole (ABT) was added to an exposure system made from dichlorprop (DCPP) enantiomers in the model plant Arabidopsis thaliana. The results indicated that different phytotoxicities of DCPP enantiomers by causing oxidative stress and acetyl-CoA carboxylase (ACCase) damage were observed in the presence and the absence of ABT. The addition of ABT decreased the toxicity of (R)-DCPP but was not significantly affected that of (S)-DCPP, resulting in smaller differences between enantiomers. Furthermore, profound differences were also observed in Fe uptake and distribution, exhibiting different distribution patterns in A. thaliana leaves exposed to DCPP and ABT, which helped bridge the relationship between ROS production and target enzyme ACCase damage through the function of CYP450s. These results offer an opportunity for a more-comprehensive understanding of chiral herbicide action mechanism and provide basic evidence for risk assessments of chiral herbicides in the environment.",
        "keywords": "",
        "authors": [
            {
                "name": "Zunwei Chen",
                "org": "Department of Veterinary Integrative Bioscience, Texas A&M University , College Station, Texas 77843, United States."
            },
            {
                "name": "Jia Wang",
                "org": "MOE Key Laboratory of Environmental Remediation & Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University , Hangzhou 310058, China."
            },
            {
                "name": "Hui Chen",
                "org": "MOE Key Laboratory of Environmental Remediation & Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University , Hangzhou 310058, China."
            },
            {
                "name": "Yuezhong Wen",
                "org": "MOE Key Laboratory of Environmental Remediation & Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University , Hangzhou 310058, China."
            },
            {
                "name": "Weiping Liu",
                "org": "MOE Key Laboratory of Environmental Remediation & Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University , Hangzhou 310058, China."
            }
        ],
        "venue": "Environmental science & technology",
        "year": 2017
    },
    "sdFUVX5w": {
        "id": "sdFUVX5w",
        "title": "Study on electro-catalytic oxidation of paranitrophenol by In-doped SnO_2/Ti process",
        "abstract": "The In-doped SnO2/Ti poles were prepared by sol-gel process.In-doped SnO2/Ti poles were used as anode,Ti was used as cathode to degrade paranitrophenol.Factors affecting the removal rate were investigated,such as voltaic density,interelectrode distance,pH ect.Under the optimal conditions of voltaic density 20 mA/cm2,I nterelectrode distance 2 cm,pH 1 and electrolysis time 5 h,the removal rate of paranitrophenol was 96.2%.And the middle outcome of the treatment was studied with HPLC annlysis method.",
        "keywords": [
            "electric catalytic",
            "electrolysis",
            "paranitrophenol"
        ],
        "authors": [
            {
                "name": "HUANG Xin-wen",
                "org": "College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "LU Xiao-qin",
                "org": "College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "LIU Chun-qian",
                "org": "College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou ,China"
            }
        ],
        "venue": "Journal of Zhejiang University of Technology",
        "year": 2009
    },
    "7bmXWUHB": {
        "id": "7bmXWUHB",
        "title": "Sensitive Determination of DNA Based on the Interaction between Norfloxacin\u2212Tb<sup>3+</sup>Complex and DNA",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Changlun Tong",
                "org": ""
            },
            {
                "name": "Zhou Hu",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            }
        ],
        "venue": "Journal of Agricultural and Food Chemistry",
        "year": 2005
    },
    "fBECTamb": {
        "id": "fBECTamb",
        "title": "Enantioselective Effects of Metalaxyl Enantiomers in Adolescent Rat Metabolic Profiles Using NMR-Based Metabolomics.",
        "abstract": "More than 30% of the registered pesticides are chiral with one or more chiral centers and exist as two or more enantiomers. The frequency of chiral chemicals and their environmental safety has been considered in their risk assessment in recent decades. Despite the fact that metabolic disturbance is an important sensitive molecular initiating event of toxicology effects, the potential mechanisms of how chiral compounds affect metabolism phenotypes in organisms remain unclear. As a typical chiral pesticide, metalaxyl is an acylalanine fungicide with systemic function. Although the fungicidal activity almost comes from the R-enantiomer, the toxicity of both enantiomers in animals and human beings is not yet clear. In this study, a nuclear magnetic resonance (NMR)-based metabolomics approach was adopted to evaluate the enantioselectivity in metabolic perturbations in adolescent rats. On the basis of multivariate statistical results, stable and evident metabolic profiles of the enantiomers were obtained. When rats were exposed to R-metalaxyl, the significantly perturbed metabolic pathways were biosynthesis of valine, leucine, and isoleucine, synthesis and degradation of ketone bodies, and metabolism of glycerolipid. In contrast, more significantly perturbed metabolic pathways were obtained when the rats were exposed to S-metalaxyl, including glycolysis, biosynthesis of valine, leucine, and isoleucine, metabolism of glycine, serine, and threonine, synthesis and degradation of ketone bodies, metabolism of glycerophospholipid and glycerolipid. These abnormal metabolic pathways were closely related to liver metabolism. These results offer more detailed information about the enantioselective metabolic effects of metalaxyl in adolescent development and provide data for the health risk assessment of metalaxyl at molecular level.",
        "keywords": "",
        "authors": [
            {
                "name": "Jinping Gu",
                "org": ""
            },
            {
                "name": "Chenyang Ji",
                "org": ""
            },
            {
                "name": "Siqing Yue",
                "org": ""
            },
            {
                "name": "Dan Shu",
                "org": ""
            },
            {
                "name": "Feng Su",
                "org": ""
            },
            {
                "name": "Yinjun Zhang",
                "org": ""
            },
            {
                "name": "Yuanyuan Xie",
                "org": ""
            },
            {
                "name": "Yi Zhang",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": "College of Environment & Resource Sciences , Zhejiang University , Hangzhou 310058 , China."
            },
            {
                "name": "Meirong Zhao",
                "org": ""
            }
        ],
        "venue": "Environmental science & technology",
        "year": 2018
    },
    "WKhxosyX": {
        "id": "WKhxosyX",
        "title": "Influence of toxicity and dissipation of racemic fenoxaprop and its R-enantiomer in Scenedesmus obliquus suspension by cyclodextrins.",
        "abstract": "Cyclodextrins (CDs), a class of cyclic oligosaccharide molecules containing a variety of chiral centre, are capable of recognizing enantiomeric molecules through the formation of inclusion complexes. In this work, we selected three types of CDs, beta-CD and its two derivatives, randomly methylated beta-CD (RAMEB) and hydroxypropyl beta-CD (HP-beta-CD), to evaluate effects on toxicity of racemic fenoxaprop (rac-FA) and its R-enantiomer (R-FA) to freshwater alga Scenedesmus obliquus (S. obliquus) and their dissipation in S. obliquus suspension with and without CDs addition, respectively, in an attempt to get more detail about enantioselective behavior of fenoxaprop acid (FA) in the environment, using CDs as a remediation agent for FA and formulation additive for fenoxaprop-p-ethyl (FE). The significant difference between rac-FA and R-FA was not observed in their acute toxicity to S. obliquus and dissipation in S. obliquus suspension. RAMEB had no effect on either toxicity of FA to S. obliquus or dissipation of FA in S. obliquus suspension, and it also didn't change the extent of enantioselectivity in toxicity of FA to S. obliquus. But the addition of a certain amount of beta -CD and HP-beta -CD reduced the toxicity of FA to S. obliquus and increased dissipation of FA in S. obliquus suspension, as well as changed the enantioselectivity in toxicity of FA to S. obliquus. The results indicated beta-CD and HP-beta-CD could be used as a promising agent for remediation of aquatic contamination produced by FA, and RAMEB might be used as potential formulation additives for FE, the parent compound of FA, as RAMEB didn't decrease activity of R-FA and might be environmentally safer than the conventional additives.",
        "keywords": [
            "cyclodextrin",
            "enantioselectivity",
            "fenoxaprop",
            "inclusion complex",
            "acute toxicity"
        ],
        "authors": [
            {
                "name": "Anping Zhang",
                "org": ""
            },
            {
                "name": "Chao Xu",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            }
        ],
        "venue": "Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes",
        "year": 2008
    },
    "r6lTX4RF": {
        "id": "r6lTX4RF",
        "title": "Metolachlor stereoisomers: Enantioseparation, identification and chiral stability.",
        "abstract": "Metolachlor is a chiral herbicide consisting of four stereoisomers, which is typically used as a racemic mixture or is enriched with the herbicidally active 1'S-isomers. Because studies on the enantioselective behavior of phyto-biochemical processes and the environmental fate of metolachlor have become significant, a practical method for analyzing and separating metolachlor stereoisomers must be developed. In the present study, the enantiomeric separation of metolachlor was achieved using OD-H, AS-H, OJ-H and AY-H chiral columns. The effects of different organic modifiers in an n-hexane-based mobile phase were investigated, and various temperatures and flow rates, which may influence metolachlor separation, were also explored. The optimal resolution was obtained using an AY-H column with n-hexane/EtOH (96/4) as the mobile phase at a rate and temperature of 0.6mLmin(-1) and 25\u00b0C, respectively. The absolute configuration of the four stereoisomers was identified as \u03b1SS, \u03b1RS, \u03b1SR, \u03b1RR using computed and experimentally measured ECD and VCD spectra. Thermal interconversion and solvent stability experiments were also performed. Pure metolachlor stereoisomers in different organic solvents and water at 4\u00b0C or 30\u00b0C were stable. These results were used to establish a sound method for analyzing, preparing, characterizing, and preserving individual metolachlor stereoisomers in most natural environments. ",
        "keywords": [
            "Chiral stability",
            "Electronic circular dichroism",
            "Enantioseparation",
            "Metolachlor stereoisomers",
            "Vibrational circular dichroism"
        ],
        "authors": [
            {
                "name": "Jingqian Xie",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Lijuan Zhang",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Lu Zhao",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Qiaozhi Tang",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Kai Liu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Weiping Liu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: wliu@zju.edu.cn."
            }
        ],
        "venue": "Journal of chromatography. A",
        "year": 2016
    },
    "6yebHkdQ": {
        "id": "6yebHkdQ",
        "title": "Distribution of organochlorine pesticides in sediments from Yangtze River Estuary and the adjacent East China Sea: implication of transport, sources and trends.",
        "abstract": "Thirty-eight surface sediments and two sediment cores were collected from Yangtze River Estuary (YRE) and adjacent East China Sea (ECS) to study the distribution patterns, origins, potential transport and burden of organochlorine pesticides (OCPs) in the marginal sea. Residues of OCPs ranged from 0.190 to 5.17 ng g(-1) dry weight with a distinct \"band type\" pattern under the control of Yangtze River inputs and ECS circulation system. Differences in transmission media and redox conditions in situ respectively resulted in the divergent distributions of \u03b1/\u03b2-HCH and DDD/DDE. The compositional pattern analysis implied that OCPs in the inner shelf of ECS were derived from both \"weathered\" and fresh sources, whereas those in the outer shelf of ECS had undergone high metabolism. Concurrent with the land-sea migration, vertical profiles of sediment cores showed increasing trends or rebound since the 1990s, characteristic of two evident \"jumps\" of DDE+DDD/DDT and DDT/DDE ratios. Moreover, the primary distribution pattern founded for HCHs and the considerable mass inventories calculated (6.20 metric tones for OCPs) together suggested that the contaminated sediments in the studied area to be a potential source of OCPs to the global ocean.",
        "keywords": [
            "Chlordanes",
            "DDTs",
            "HCHs",
            "Mass inventory",
            "Pollution trend"
        ],
        "authors": [
            {
                "name": "Shanshan Zhou",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China; IJRC-PTS, MOE Key Laboratory of Environmental Remediation and Ecosystem Health, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Huayun Yang",
                "org": "Environmental Protection Research Institute, Hangzhou Normal University, Hangzhou 310012, China."
            },
            {
                "name": "Anping Zhang",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China."
            },
            {
                "name": "Yi-Fan Li",
                "org": "IJRC-PTS, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China."
            },
            {
                "name": "Weiping Liu",
                "org": "IJRC-PTS, MOE Key Laboratory of Environmental Remediation and Ecosystem Health, Zhejiang University, Hangzhou 310058, China."
            }
        ],
        "venue": "Chemosphere",
        "year": 2014
    },
    "Kt4LN1Md": {
        "id": "Kt4LN1Md",
        "title": "Effects of beta-cyclodextrins on the enzymatical hydrolysis of chiral dichlorprop methyl ester.",
        "abstract": "The effect of beta-cyclodextrins (beta-CDs) on the enzymatical hydrolysis of chiral dichlorprop methyl ester (DCPPM) was studied. Four kinds of beta-cyclodextrins (beta-cyclodextrin, Partly methylated-CD (PM-beta-CD), hydroxypropyl-cyclodextrin (HP-beta-CD) and carboxymethyl-cyclodextrin (CM-beta-CD)) were used. Compared with 100% DCPPM in the absence of betacyclodextrins, the activity of lipase decreased with the increase of Pbetacyclodextrin and PM-Pbetacyclodextrin. However, CM-beta-clodextrin stimulated the lipase activity. The inhibition effect of Pbeta cyclodextrin and PM-5betacyclodextrin on the hydrolysis of DCPPM is affected by many factors other than degree of the methylation blocking the active site of lipase. UV-Vis and Fourier transform infrared (FTIR) spectroscopy studies of the complexation of aqueous DCPPM with beta-CDs provide fresh insight into the molecular structure of the complex and explain the effects of beta-CDs on enzymatical hydrolysis of chiral DCPPM. Data showed that inclusion complexes had formed by complexation of the CM-beta-CD with DCPPM and the solubility of DCPPM was increased in water, which lead to the increased lipase activity.",
        "keywords": [],
        "authors": [
            {
                "name": "Yue-Zhong Wen",
                "org": "Institute of Environment Science, Zhejiang University, Hangzhou 310029, China. wenyuezhong@zjuem.zju.edu.cn"
            },
            {
                "name": "Shan-shan Zhou",
                "org": ""
            },
            {
                "name": "Zhao-hua Fang",
                "org": ""
            },
            {
                "name": "Wei-ping Liu",
                "org": ""
            }
        ],
        "venue": "Journal of environmental sciences (China)",
        "year": 2005
    },
    "L4yxAxfI": {
        "id": "L4yxAxfI",
        "title": "Levels and distribution of Dechlorane Plus and related compounds in surficial sediments of the Qiantang River in eastern China: the results of urbanization and tide.",
        "abstract": "Dechloranes, including Mirex, Dechlorane 602 (Dec 602), Dechlorane 603 (Dec 603), Dechlorane 604 (Dec 604) and Dechlorane Plus (DP), are a class of chlorinated flame retardants. To investigate the effect of urbanization and tide on the distribution of Dechloranes in sediment, we assayed surficial sediments collected from the Qiantang River in eastern China for the presence of these chemicals. The concentrations of Mirex, Dec 602, Dec 603, and DP ranged from below detection limit (BLD) to 0.68 ng/g dry weight (dw), BLD-0.048 ng/g dw, BLD-0.026 ng/g dw, and BLD-1.1 ng/g dw, respectively. Dechloranes 604 was not detected in any sediment samples. It was evident that local urban and industrial activities were the primary source of DP in surficial sediments in the Qiantang River, which was supported by the fact that the average DP concentration of sediment samples in urban sites was approximately three-fold higher than that in rural sites. An extremely high concentration of DP at a reservoir site in a rural area indicated that a dam can block the movement of DP in the Qiantang River by slowing down the river current and making the reservoir the primary sink of DP. Furthermore, the spatial distribution of Dechloranes suggested that concentrations of Dechloranes in sediment in the tide zone were much lower than those in the non-tidal zone, indicating that tide played an important role in transportation and re-distribution of Dechloranes in sediments of the Qiantang River.",
        "keywords": [
            "spatial distribution",
            "tide",
            "qiantang river",
            "sediment",
            "urbanization",
            "dechlorane plus"
        ],
        "authors": [
            {
                "name": "Jianqiang Sun",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Anping Zhang",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Li Fang",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Junliang Wang",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "The Science of the total environment",
        "year": 2013
    },
    "s5Qfe7Ne": {
        "id": "s5Qfe7Ne",
        "title": "Disruption of the Hormonal Network and the Enantioselectivity of Bifenthrin in Trophoblast: Maternal\u2013Fetal Health Risk of Chiral Pesticides",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "chengsheng lu",
                "org": ""
            },
            {
                "name": "quan zhang",
                "org": ""
            },
            {
                "name": "shulin zhuang",
                "org": ""
            },
            {
                "name": "ying zhang",
                "org": ""
            },
            {
                "name": "meirong zhao",
                "org": ""
            }
        ],
        "venue": "Environmental Science & Technology",
        "year": 2014
    },
    "Agr47IJ4": {
        "id": "Agr47IJ4",
        "title": "Residues, sources and tissue distributions of organochlorine pesticides in dog sharks (Mustelus griseus) from Zhoushan Fishing Ground, China.",
        "abstract": "Ten dog sharks (Mustelus griseus) collected from Zhoushan Fishing Ground, China, were analysed for organochlorine pesticides in various tissues, including muscle, liver, skin, gill and fin, with the aim to study the residues, sources and tissue distributions of these chemicals in high trophic level marine fishes. The concentrations of DDTs, HCHs, and chlordanes varied from 7.27-26.62, 2.67-3.35, and 0.54-0.61 ng/g wet weight, respectively, with the estimated daily intake far below the acceptable daily intake and Chinese edible hygienic criteria. Data from the tissue distribution suggested a tendency of DDTs and chlordanes to accumulate in the liver, but for HCHs, direct gill penetration may be an important means of entrance. In addition, the compositional profiles indicated that the residues of HCHs and chlordanes mainly originated from the historical usage of these chemicals. However, the predominant maternal compounds and the o,p'-DDT/p,p'-DDT ratios reflected a recent use of dicofol.",
        "keywords": [
            "Chlordane",
            "hexachlorocyclohexane",
            "East China Sea",
            "east china sea",
            "dichlorodiphenyltrichloroethane",
            "chlordane",
            "Hexachlorocyclohexane",
            "Dichlorodiphenyltrichloroethane"
        ],
        "authors": [
            {
                "name": "Shanshan Zhou",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Lu Tong",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Qiaozhi Tang",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Xiaoting Gu",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Bin Xue",
                "org": "State Oceanic Administration China(State Oceanic Administration,SOA),Xiamen,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Marine pollution bulletin",
        "year": 2013
    },
    "WIxlqFxi": {
        "id": "WIxlqFxi",
        "title": "Status of mercury accumulation in agricultural soil across China: Spatial distribution, temporal trend, influencing factor and risk assessment.",
        "abstract": "Given its wide distribution in the natural environment and global transport potential, mercury (Hg) is regarded as a ubiquitous pollutant. In this study, we carried out nation-wide sampling campaigns across China to investigate the distribution of Hg in agricultural soils. Concentrations of Hg in the soils collected in 2011 and 2016 ranged from 0.04 to 0.69 and 0.06-0.78\u202fmg\u202fkg, respectively. Based on the data from 2016, the reserve of Hg in the surface arable soils (0-20\u202fcm) in China was 4.1\u202f\u00d7\u202f10 metric tons and Chinese cultivated soils accounted for 63.4-364 metric tons of Hg released to the global atmosphere. The soil Hg concentrations were significantly higher than the reference background level, highlighting the impacts of anthropogenic activities. The vertical distribution pattern showed a clear enrichment at the surface and a decrease with depth of the soils. Comparison of calculated geo-accumulation indexes among individual provinces showed that Northwest China had higher levels of Hg contamination than other regions of China, likely due to long-term energy related combustions in the area. Soil Hg level showed strong positive correlations with organic matter contents of soil, as well as the mean annual precipitation and temperature of the sampling locations. The non-carcinogenic human health risks of soil Hg were below the threshold level, but the general risk to the ecosystem was considerable. The increases in Hg accumulation from 2011 to 2016\u202fat provincial level were found to relate to coal combustion, power generation and per capita GDP. This examination of energy consumption and socioeconomic drivers for China's soil Hg reserve increase is critical for direct Hg control by guiding policy-making and targets of technology development in era of rapid economic growth.",
        "keywords": [
            "China energy consumption",
            "Ecological and human health risk",
            "Soil mercury",
            "Spatial distribution",
            "Temporal trend"
        ],
        "authors": [
            {
                "name": "Yuting Zhou",
                "org": "International Joint Research Center for Persistent Toxic Substances, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Muhammad Aamir",
                "org": "International Joint Research Center for Persistent Toxic Substances, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Kai Liu",
                "org": "Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA 91125, USA."
            },
            {
                "name": "Fangxing Yang",
                "org": "International Joint Research Center for Persistent Toxic Substances, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Weiping Liu",
                "org": "International Joint Research Center for Persistent Toxic Substances, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: wliu@zju.edu.cn."
            }
        ],
        "venue": "Environmental pollution (Barking, Essex : 1987)",
        "year": 2018
    },
    "rlSCezs9": {
        "id": "rlSCezs9",
        "title": "Screening of chemicals with anti-estrogenic activity using in vitro and in vivo vitellogenin induction responses in zebrafish (Danio rerio).",
        "abstract": "Growing concern over possible adverse effects of endocrine-disrupting chemicals (EDCs) has driven the development of associated screening methods. The use of the vitellogenin (VTG) induction response in cultured teleost hepatocytes has been suggested as an in vitro screening assay for EDCs. However, current data do not sufficiently support this assay in the routine screening of chemicals. This study established and validated the use of primary cultured hepatocytes from zebrafish to screen chemicals for anti-estrogenic activities. Here we measured the transcript levels of selected hepatic estrogen-response genes, including vtg1, vtg2 and eralpha. Two model anti-estrogens, letrozole (LET), an aromatase inhibitor, and tamoxifen (TAM), a competitive estrogen receptor, were selected as representative chemicals. Additionally, comparisons between in vitro and in vivo assays were performed. As expected, there were concentration-dependent decreases for all three genes in the liver of female zebrafish exposed to LET in vivo for 72h. Similar responses were observed in males. As for in vitro testing, no discernable alterations in the gene transcripts were found in hepatocytes from males or females. In the case of TAM, exposure for 72h caused transcriptional reduction of hepatic estrogen-response genes in females in vivo and in vitro. In males, low concentrations of TAM resulted in increased expression of genes, while the expression decreased slightly at higher concentrations. Since these observations were in agreement with the pharmaceutical properties of two tested chemicals, the primary hepatocyte culture could be a promising tool for screening suspected EDCs.",
        "keywords": [
            "anti-estrogen",
            "mtt assay",
            "primary hepatocyte culture",
            "real-time quantitative pcr"
        ],
        "authors": [
            {
                "name": "Liwei Sun",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Liling Wen",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Xiaolu Shao",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Haifeng Qian",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Yuanxiang Jin",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Weiping Liu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Zhengwei Fu",
                "org": ""
            }
        ],
        "venue": "Chemosphere",
        "year": 2010
    },
    "YYJaBg9I": {
        "id": "YYJaBg9I",
        "title": "Potential endocrine-disrupting effects of metals via interference with glucocorticoid and mineralocorticoid receptors.",
        "abstract": "As a result of human activities, the pollution of metals is becoming ubiquitous in the environment. Among various toxicological mechanisms of action, metals have been considered as endocrine-disrupting chemicals (EDCs) through interference with steroid receptors. However, information regarding the potential endocrine disruption of metals on glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) is especially scarce. In this study, a total of 16 metals were assessed for their GR/MR activities using luciferase reporter gene assay. None of the tested metals exhibited GR or MR agonistic activity, but a total of 7 and 5 candidate metals showed obvious GR and MR antagonistic properties, respectively. All 7\u202fGR antagonistic metals [ BaCl, CoCl, CuCl, Pb(NO), LiCl, SnCl and ZnCl] inhibited glucocorticoid-responsive gene GILZ expression in J774A.1\u202fcells. Further investigations indicated that the 5\u202fMR antagonistic metals [ CdCl, Pb(NO), LiCl, MnCl and SnCl] antagonized aldosterone-inhibited hepatocellular carcinoma cell proliferation. Among these metals, Pb(NO), LiCl, and SnCl showed both anti-glucocorticoid and anti-mineralocorticoid activities. Comprehensive screening and evaluation of GR and MR antagonists and agonists among metals should be considered to better understand the ecological and health risks of metals.",
        "keywords": [
            "Endocrine-disrupting chemicals",
            "Glucocorticoid receptor",
            "Metal",
            "Mineralocorticoid receptor",
            "Steroid hormone receptors"
        ],
        "authors": [
            {
                "name": "Jianyun Zhang",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China; Institute of Environmental Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Ye Yang",
                "org": "Institute of Hygiene, Zhejiang Academy of Medical Sciences, Hangzhou, China."
            },
            {
                "name": "Weiping Liu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China; Institute of Environmental Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China; Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Jing Liu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China; Institute of Environmental Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China; Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: jliue@zju.edu.cn."
            }
        ],
        "venue": "Environmental pollution (Barking, Essex : 1987)",
        "year": 2018
    },
    "RiSKZIlc": {
        "id": "RiSKZIlc",
        "title": "Fe-N-Graphene Wrapped Al 2 O 3 /Pentlandite from Microalgae: High Fenton Catalytic Efficiency from Enhanced Fe 3+ Reduction.",
        "abstract": "Efficient cycling of Fe3+/Fe2+ is a key step for the Fenton reaction. In this exploration, from microalgae, we have prepared a novel Fe-N-graphene wrapped Al2O3/pentlandite composite which showed high Fenton catalytic ability through accelerating of Fe3+ reduction. The catalyst exhibits high activity, good reusability along with stability, and wide adaptation for the organics degradation under neutral pH. High TON and H2O2 utilization efficiency have also reached by this catalyst. Characterization results disclose a unique structure that the layered Fe-N-graphene structure tightly covers on Al2O3/pentlandite particles. Mechanistic evidences suggest that the accelerated Fe3+/Fe2+ redox cycle originates from the enhanced electron transfer by the synergistic effect of Fe, Ni and Al in the catalyst, and it causes the low H2O2 consumption and high \u2022OH generation rate. Moreover, organic radicals formed in the Fenton process also participate in the Fe3+ reduction, and this process may be accelerated by the N doped graphene through a quick electron transfer. These findings stimulate an approach with great potential to further extend the synthetic power and versatility of Fenton catalysis through N doped graphene in catalysts.",
        "keywords": "",
        "authors": [
            {
                "name": "Jianqing Ma",
                "org": ""
            },
            {
                "name": "Lili Xu",
                "org": ""
            },
            {
                "name": "Chensi Shen",
                "org": ""
            },
            {
                "name": "Chun Hu",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Yuezhong Wen",
                "org": ""
            }
        ],
        "venue": "Environmental science & technology",
        "year": 2018
    },
    "7rfCXAkE": {
        "id": "7rfCXAkE",
        "title": "Congener-specific composition of polychlorinated biphenyls (PCBs) in soil-air partitioning and the associated health risks.",
        "abstract": "The recent changes in the compositions of polychlorinated biphenyls (PCBs) after their restriction for 40\u202fyears may have various effects on human health. In order to characterize the congener-specific compositions of PCBs in the soil-air process and assess the associated human health risks, soil and air samples were simultaneously collected in winter and summer at two different functional locations. Homologue patterns suggest that long-range atmospheric transport might be the major source of soil and air residues of PCBs. The net deposition from air to soil was overwhelming for most PCB congeners. Variations in the occurrence and the homologue patterns of PCBs between the soil and air interface depended on chemical volatility, soil organic matter (OM) content, ambient temperature, topographical condition and atmospheric transport. Dioxin-like PCBs accounted for 11.0-70.3% and 2.31-54.8% of total PCB residues in soil and air, respectively. Non-carcinogenic and carcinogenic risks associated with exposure to soil and air PCBs were also estimated. Different PCB congeners showed different health effects, with the highest contribution from PCB-26. Additionally, the non-carcinogenic risk levels of PCBs were enhanced, while the carcinogenic risk levels decreased during the soil-air exchange process of PCBs with time. Our results highlight the soil-air interaction of PCBs in predicting their potential human exposure health risks.",
        "keywords": [
            "Air-soil exchange",
            "Health risk assessment",
            "Homologue profile",
            "Polychlorinated biphenyl",
            "Soil-air partitioning",
            "Toxicity equivalency"
        ],
        "authors": [
            {
                "name": "Chao Xu",
                "org": "College of Environment, Zhejiang University of Technology, Hangzhou 310014, China."
            },
            {
                "name": "Lili Niu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: niulili@zju.edu.cn."
            },
            {
                "name": "Deliang Zou",
                "org": "College of Environment, Zhejiang University of Technology, Hangzhou 310014, China."
            },
            {
                "name": "Siyu Zhu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Weiping Liu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            }
        ],
        "venue": "The Science of the total environment",
        "year": 2019
    },
    "VCQAiFQi": {
        "id": "VCQAiFQi",
        "title": "Glucocorticoid and mineralocorticoid receptors and corticosteroid homeostasis are potential targets for endocrine-disrupting chemicals",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jianyun Zhang",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China"
            },
            {
                "name": "Ye Yang",
                "org": "Institute of Hygiene, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China"
            },
            {
                "name": "Weiping Liu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China"
            },
            {
                "name": "Daniel Schlenk",
                "org": "Department of Environmental Sciences, University of California, Riverside, 900 University Avenue, Riverside, CA 92521, United States"
            },
            {
                "name": "Jing Liu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China"
            }
        ],
        "venue": "Environment International",
        "year": 2019
    },
    "9QNWRIgF": {
        "id": "9QNWRIgF",
        "title": "Assessment of arsenic in colostrum and cord serum and risk exposure to neonates from an island population in China.",
        "abstract": "Arsenic (As) has been proven to be highly toxic to humans, but limited attention has focused on exposure levels and potential risks to mother-neonate pairs of coastal populations. This study was conducted by examining the As concentration in colostrum and umbilical cord serum collected from 106 mother-neonate pairs living on Shengsi Island, facing the Yangtze River estuary and Hangzhou Bay in China. Average concentrations of total As in colostrum and cord serum were 18.51\u00a0\u00b1\u00a07.00 and 19.83\u00a0\u00b1\u00a010.50\u00a0\u03bcg\u00a0L. One-way ANOVA analysis showed delivered ages and source of drinking water played significant roles in influencing the maternal exposure patterns. Correlation analysis indicated a significantly positive association between As concentrations in colostrum and cord serum. Multivariable linear regression models adjusted for other confounders clarified the dose-response relationship with a coefficient value of 0.23 and a 95\u00a0% confidence interval of (0.006, 0.492); p\u00a0<\u00a00.05. The calculated daily intake of total As for neonates through breastfeeding was in the range from 0.413 to 3.65\u00a0\u03bcg\u00a0kg body weight, and colostrum As, especially the most toxic species, inorganic arsenic (iAs), would pose a risk to neonates.",
        "keywords": [
            "Arsenic",
            "Colostrum",
            "Correlation analysis",
            "Exposure assessment",
            "Inorganic arsenic speciation",
            "Umbilical cord serum"
        ],
        "authors": [
            {
                "name": "Chenye Xu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China."
            },
            {
                "name": "Mengling Tang",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China."
            },
            {
                "name": "Siyu Zhu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China."
            },
            {
                "name": "Hua Naranmandura",
                "org": "Department of Toxicology, School of Medicine and Public Health, Zhejiang University, Hangzhou, 310058, China."
            },
            {
                "name": "Weiping Liu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China. wliu@zju.edu.cn."
            }
        ],
        "venue": "Environmental science and pollution research international",
        "year": 2016
    },
    "DHsjJc3T": {
        "id": "DHsjJc3T",
        "title": "Enantioselective effects of chiral herbicide diclofop acid on rice Xiushui 63 seedlings.",
        "abstract": "In this study, the acute toxicity (72-h EC50 values) of chiral diclofop acid towards rice Xiushui 63 seedlings and its effects on the Hill reaction activities of chloroplasts were determined. Significant differences were observed\n between the two enantiomers in 72-h EC50 values and in both in vivo and in vitro relative Hill reaction activities. These\n observations indicate that the enantiomers of diclofop acid pose different toxicities to rice seedlings: the S-enantiomer is more toxic to leaves and the R-enantiomer is more toxic to roots. These enantioselective toxic effects on rice seedlings should be taken into account in\n chiral herbicide application.",
        "keywords": [
            "diclofop",
            "enantioselectivity",
            "rice xiushui 63",
            "toxicity",
            "chloroplasts",
            "selectivity",
            "enantiomers",
            "leaves",
            "acute toxicity"
        ],
        "authors": [
            {
                "name": "Jing Ye",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Qiong Zhang",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Anping Zhang",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Yuezhong Wen",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            }
        ],
        "venue": "Bulletin of environmental contamination and toxicology",
        "year": 2009
    },
    "Zatbc8f7": {
        "id": "Zatbc8f7",
        "title": "Induction of hepatic estrogen-responsive gene transcription by permethrin enantiomers in male adult zebrafish.",
        "abstract": "Despite recent studies on enantioselectivity in acute aquatic toxicity and biodegradation of some pyrethroid pesticides, including permethrin (PM), enantiomer-specific estrogenic activity has been the subject of limited research. In this study, real-time quantitative RT-PCR was adopted to investigate induction of hepatic expression of mRNA of selected genes in male adult zebrafish after short-term exposure to PM enantiomers. The PM enantiomers were completely separated by a chiral HPLC column. The in vivo study found that a 2-day exposure to 100 ng/l PM racemate and its enantiomers was sufficient to stimulate transcription of two vitellogenin (vtg) genes, while 250 ng/l exposure significantly induced gene transcription in a pattern and content similar to that of the control (50 ng/l 17beta-estradiol (E2)). Significant differences were detected between the enantiomers in induction of hepatic gene transcription. At exposure level of 500 ng/l, the response to the (-)-trans enantiomer was 2.6 and 1.8 times greater than the (+)-trans enantiomer based on zebrafish vtg1 and vtg2 mRNA induction (p<0.05), respectively. Of the four enantiomers, the (-)-trans enantiomer showed the greatest estrogenic activity, with a relative activity 4-fold higher than the 50 ng/l E2 group. The results strongly suggested the occurrence of significant enantioselectivity in estrogenic activity of PM enantiomers. It would appear from our results and previous studies that using chiral pesticide as a single compound would increase the environmental risk of chronic toxicity, such as endocrine disruption, to humans and wildlife.",
        "keywords": [
            "enantioselectivity",
            "gene expression",
            "permethrin enantiomers",
            "zebrafish",
            "chronic toxicity",
            "gene transcription"
        ],
        "authors": [
            {
                "name": "Yuanxiang Jin",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, No. 18, Chaowang Road, Hangzhou 310032, China"
            },
            {
                "name": "Wanyuan Wang",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, No. 18, Chaowang Road, Hangzhou 310032, China"
            },
            {
                "name": "Chao Xu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, No. 18, Chaowang Road, Hangzhou 310032, China"
            },
            {
                "name": "Zhengwei Fu",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            }
        ],
        "venue": "Aquatic toxicology (Amsterdam, Netherlands)",
        "year": 2008
    },
    "EFId4yeW": {
        "id": "EFId4yeW",
        "title": "Levels and patterns of DDTs in maternal colostrum from an island population and exposure of neonates.",
        "abstract": "Dichlorodiphenyltrichloroethane (DDT) was heavily used in the past in many regions of the world. The occurrence of DDTs in island populations may be elevated if the island is adjacent to major DDT consumption estuaries, such as the Yangtze River Delta. In this study, colostrum samples were collected from maternal-neonate pairs (n = 106) from the Shengsi Island, located directly downstream from the Yangtze River outlet. DDT isomers and enantiomer compositions were analyzed by gas chromatography equipped with mass spectrometer (GC/MS) and GC/MS-MS. The average levels of p,p'-DDE, o,p'-DDD, p,p'-DDD, o,p'-DDT, p,p'-DDT and total DDTs were 1.32, 0.03, 0.09, 0.08, 0.48, and 1.93  \u03bcg g(-1) lipid weight, respectively. Maternal age and pregnancy body mass index (BMI) were positively associated with levels of DDTs (p < 0.05). High (DDE+DDD)/DDT and p,p'-DDE/p,p'-DDT ratios suggested that current DDT residues originated primarily from historical use of DDT products, but new sources may also contribute partially to some high o,p'-DDT/p,p'-DDT ratios. Enantiomeric enrichment was found for the (-)-enantiomer of o,p'-DDD and the (+)-enantiomer of o,p'-DDT, suggesting stereoselective attenuation. Based on breast milk consumption, the average daily intake of DDTs by neonates was 8.33 \u00b1 7.34 \u03bcg kg(-1)bw per day, which exceeded the WHO's tolerable daily intake guideline of 0.01 mg kg(-1) bw per day by 25%, implying some neonates in the Yangtze River region are potentially at high risk from exposure to DDTs.",
        "keywords": [
            "Dichlorodiphenyltrichloroethane (DDT)",
            "Enantioselective patterns",
            "Exposure assessment",
            "Maternal colostrum",
            "Source identification"
        ],
        "authors": [
            {
                "name": "Chenye Xu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Mengling Tang",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Honghui Zhang",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Chunlong Zhang",
                "org": "Program of Environmental Science, University of Houston-Clear Lake, Houston, TX 77058, USA."
            },
            {
                "name": "Weiping Liu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            }
        ],
        "venue": "Environmental pollution (Barking, Essex : 1987)",
        "year": 2015
    },
    "hTxI3tkL": {
        "id": "hTxI3tkL",
        "title": "Enantiomeric separation of imidazolinone herbicides using chiral high-performance liquid chromatography.",
        "abstract": "Chiral high-performance liquid chromatography (HPLC) is one of the most powerful tools to prepare enantiopure standards of chiral compounds. In this study, the enantiomeric separation of imidazolinone herbicides, i.e., imazethapyr, imazapyr, and imazaquin, was investigated using chiral HPLC. The enantioselectivity of Chiralpak AS, Chiralpak AD, Chiralcel OD, and Chiralcel OJ columns for the three analytes was compared under similar chromatographic conditions. Chiralcel OJ column showed the best chiral resolving capacity among the test columns. The resolved enantiomers were distinguished by their signs of circular dichroism detected at 275 nm and their structures confirmed with LC-mass spectrometric analysis. Factors affecting the chiral separation of imidazolinones on Chiralcel OJ column were characterized. Ethanol acted as a better polar modifier than the other alcohols including 2-propanol, 1-butanol, and 1-pentanol. Although the acidic modifier in the mobile phase did not influence chiral recognition, it was necessary for reducing the retention time of enantiomers and suppressing their peak tailing. Thermodynamic evaluation suggests that enantiomeric separation of imidazolinones on Chiralcel OJ column is an enthalpy-driven process from 10 to 40 degrees C. This study also shows that small amounts of pure enantiomers of imidazolinones may be obtained by using the analytical chiral HPLC approach.",
        "keywords": [
            "chiral pesticides",
            "chiral separation",
            "imidazolinone herbicides",
            "high performance liquid chromatography"
        ],
        "authors": [
            {
                "name": "Kunde Lin",
                "org": ""
            },
            {
                "name": "Chao Xu",
                "org": ""
            },
            {
                "name": "Shanshan Zhou",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Jay Gan",
                "org": ""
            }
        ],
        "venue": "Chirality",
        "year": 2007
    },
    "TT7fTWWa": {
        "id": "TT7fTWWa",
        "title": "Combined effect of copper and cadmium on Chlorella vulgaris growth and photosynthesis-related gene transcription.",
        "abstract": "Chlorella vulgaris was tested to assess their toxicities in freshwater contaminated by the metal compounds of copper (Cu) and cadmium (Cd), both singly and combined. Exposure to 0.5 and 1.5 microM Cu or 1.0 and 2.0 microM Cd alone significantly decreased algal growth and chlorophyll content and increased reactive oxygen species (ROS) content. Two-way ANOVA analysis shows that the combination of these two metal compounds decreased cell growth, chlorophyll content and increased ROS content synergistically. The highest algal cell inhibition was 78.55%, the lowest levels of chl a, chl b and total-chl were 10.59%, 33.33% and 17.94% of the control, respectively. The highest increase in ROS was 9.15-fold greater than that of the control when exposed to Cu(1.5)+Cd(2.0). Real-time PCR shows that Cu and Cd reduced the transcript abundance of psbA and rbcL, but without a synergistic interaction, whereas Cu and Cd increased the transcript abundance of psaB synergistically. These results demonstrate that Cu and Cd independently inhibit PSII activity and CO(2) assimilation, but synergistically increase ROS content to disrupt chlorophyll synthesis and inhibit cell growth.",
        "keywords": [
            "ros",
            "interaction",
            "copper",
            "cadmium",
            "gene transcription",
            "transcription",
            "water pollution",
            "photosynthesis",
            "growth",
            "cell growth",
            "real time pcr"
        ],
        "authors": [
            {
                "name": "Haifeng Qian",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Jingjing Li",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Liwei Sun",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Wei Chen",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "G Daniel Sheng",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Weiping Liu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Zhengwei Fu",
                "org": ""
            }
        ],
        "venue": "Aquatic toxicology (Amsterdam, Netherlands)",
        "year": 2009
    },
    "NhaYI9jI": {
        "id": "NhaYI9jI",
        "title": "Probing the molecular interaction of triazole fungicides with human serum albumin by multispectroscopic techniques and molecular modeling.",
        "abstract": "Triazole fungicides, one category of broad-spectrum fungicides, are widely applied in agriculture and medicine. The extensive use leads to many residues and casts potential detrimental effects on aquatic ecosystems and human health. After exposure of the human body, triazole fungicides may penetrate into the bloodstream and interact with plasma proteins. Whether they could have an impact on the structure and function of proteins is still poorly understood. By using multispectroscopic techniques and molecular modeling, the interaction of several typical triazole fungicides with human serum albumin (HSA), the major plasma protein, was investigated. The steady-state and time-resolved fluorescence spectra manifested that static type, due to complex formation, was the dominant mechanism for fluorescence quenching. Structurally related binding modes speculated by thermodynamic parameters agreed with the prediction of molecular modeling. For triadimefon, hydrogen bonding with Arg-218 and Arg-222 played an important role, whereas for imazalil, myclobutanil, and penconazole, the binding process was mainly contributed by hydrophobic and electrostatic interactions. Via alterations in three-dimensional fluorescence and circular dichroism spectral properties, it was concluded that triazoles could induce slight conformational and some microenvironmental changes of HSA. It is anticipated that these data can provide some information for possible toxicity risk of triazole fungicides to human health and be helpful in reinforcing the supervision of food safety.",
        "keywords": [
            "circular dichroism",
            "triazole fungicides",
            "fluorescence spectroscopy",
            "human serum albumin",
            "molecular modeling"
        ],
        "authors": [
            {
                "name": "Jing Zhang",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Shulin Zhuang",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Changlun Tong",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Journal of agricultural and food chemistry",
        "year": 2013
    },
    "jSllSpWb": {
        "id": "jSllSpWb",
        "title": "Stereoselective accumulations of hexachlorocyclohexanes (HCHs) are correlated with Sphingomonas spp. in agricultural soils across China.",
        "abstract": "The wide usage of hexachlorocyclohexanes (HCHs) as pesticides has caused soil pollution and adverse health effects through direct contact or bioaccumulation in the food chain. This study quantified major HCH isomers in farmland topsoils across China, and evaluated their correlations with microbial community structure, function, and abiotic variables (e.g., moisture, pH, and temperature). Recalcitrant \u03b2-HCH was more abundant than \u03b1-, \u03b3-, and \u03b4-HCHs, and \u03b1-HCH enantiomeric fractions (EF) were larger than 0.5, indicating preferential degradation of (-)-\u03b1-HCH. Sphingomonas was not only a predominant population (especially in samples collected in the south), but also a promising biomarker indicating total- and \u03b2-HCH residuals, and EF values of \u03b1-HCH. Soil moisture and temperature were among the most influential factors that structured the diversity and function of soil microbial communities. The results suggested that increasing soil moisture (in the range of 5-45%) would benefit the growth of HCH-degrading populations and the enrichment of HCH-degradation related pathways. Revealing the site-specific relationships between topsoil physical, chemical, and microbial properties will benefit the in situ bioremediation of farmlands with relatively low HCH residuals across the world.",
        "keywords": [
            "Biomarker",
            "Enantioselectivity",
            "HCH isomer",
            "Sphingomonas"
        ],
        "authors": [
            {
                "name": "Yang Xu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China."
            },
            {
                "name": "Lili Niu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China; College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, 310036, China."
            },
            {
                "name": "Jiguo Qiu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China; College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu, 210095, China."
            },
            {
                "name": "Yuting Zhou",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China."
            },
            {
                "name": "Huijie Lu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China; Department of Civil and Environmental Engineering, University of Vermont, 33 Colchester Ave, Burlington, VT 05405, USA. Electronic address: luhuijie@zju.edu.cn."
            },
            {
                "name": "Weiping Liu",
                "org": "International Joint Research Center for Persistent Toxic Substances (IJRC-PTS), MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China."
            }
        ],
        "venue": "Environmental pollution (Barking, Essex : 1987)",
        "year": 2018
    },
    "GpNUprZj": {
        "id": "GpNUprZj",
        "title": "Environmental exposure to polycyclic aromatic hydrocarbons (PAHs): The correlation with and impact on reproductive hormones in umbilical cord serum.",
        "abstract": "Polycyclic aromatic hydrocarbons (PAHs) are a type of ubiquitous pollutant with the potential ability to cause endocrine disruption that would have an adverse health impact on the general population. To assess the maternal exposure to PAHs in neonates and evaluate the possible impact of PAHs on reproductive hormone levels, the concentration of PAHs and reproductive hormone levels in the umbilical cord serum of 98 mother-infant pairs in the Shengsi Islands were investigated. The median concentration of total PAHs was determined to be 164 (Inter-Quartile Range, IQR 93.6-267)\u00a0ng\u00a0g lipid, and 68% of the PAHs were lower-molecule congeners. The highest level was found for pyrene (PYR) and naphthalene (NAP), which contributed 54.6% of all the PAHs present in the samples. The exposure to PAHs negatively affected estradiol (E2) and Anti-Mullerian hormones (AMH) and positively affected FSH in the umbilical cord serum. The result expanded the database of the human burden of PAHs and suggested that PAHs can act as a type of Endocrine-Disrupting Chemical (EDC). These results may help to understand the complex pathways involved in disorders of human reproductive health associated with prenatal exposure to PAHs.",
        "keywords": [
            "Environmental exposure",
            "Polycyclic aromatic hydrocarbons (PAHs)",
            "Reproductive hormones",
            "Umbilical cord serum"
        ],
        "authors": [
            {
                "name": "Shanshan Yin",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation & Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Mengling Tang",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation & Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Fangfang Chen",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation & Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Tianle Li",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation & Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Weiping Liu",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation & Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: wliu@zju.edu.cn."
            }
        ],
        "venue": "Environmental pollution (Barking, Essex : 1987)",
        "year": 2017
    },
    "jBKl8Bpd": {
        "id": "jBKl8Bpd",
        "title": "Highly efficient detoxification of Cr(VI) by chitosan-Fe(III) complex: process and mechanism studies.",
        "abstract": "Metal-biopolymer complexes has recently gained significant attention as an effective adsorbent used for the removal of Cr(VI) from water. Unfortunately, despite increasing research efforts in the field of removal efficiency, whether this kind of complex can reduce Cr(VI) to less-toxic Cr(III) and what are the mechanisms of detoxification processes are still unknown. In this study, despite the highly adsorption efficiency (maximum adsorption capacity of 173.1 mg/g in 10 min), the significant improvement of Cr(VI) reduction by chitosan-Fe(III) complex compared with normal crosslinked chitoan has been demonstrated. In addition, the structure of chitosan-Fe(III) complex and its functional groups concerned with Cr(VI) detoxification have been characterized by the powerful spectroscopic techniques X-ray absorption fine structure (XAFS) and X-ray photoelectron spectroscopy (XPS). The XPS spectra indicated that the primary alcoholic function on C-6 served as an electron donor during Cr(VI) reduction and was oxidized to a carbonyl group. The X-ray adsorption near edge spectra (XANES) of the Cr(VI)-treated chitosan-Fe(III) complex revealed the similar geometrical arrangement of Cr species as that in Cr(III)-bound chitosan-Fe(III). Overall, a possible process and mechanism for highly efficient detoxification of Cr(VI) by chitosan-Fe(III) complex has been elucidate.",
        "keywords": [
            "xafs",
            "detoxification",
            "xps",
            "chitosan-fe(iii) complex",
            "chromium"
        ],
        "authors": [
            {
                "name": "Chensi Shen",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Hui Chen",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Shaoshuai Wu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Yuezhong Wen",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Lina Li",
                "org": "Shanghai Synchrotron Radiation Facility(Shanghai Synchrotron Radiation Facility),Shanghai,China"
            },
            {
                "name": "Zheng Jiang",
                "org": "Shanghai Synchrotron Radiation Facility(Shanghai Synchrotron Radiation Facility),Shanghai,China"
            },
            {
                "name": "Meichao Li",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Journal of hazardous materials",
        "year": 2013
    },
    "tAc2fB9M": {
        "id": "tAc2fB9M",
        "title": "Effect of Metolachlor on Soil Microbial Numbers in Rhizosphere and Its Degradtion",
        "abstract": "Rhizosphere was a special area around plant roots.As a result of release of organic substances by roots,microbial numbers and activities in rhizosphere were generally higher than in root free soil.In order to investigate the influence of plant roots and rhizosphere microorganisms on bioremediation of soils contaminated with organic pollutants,the effect of metolachlor on microbial numbers and its degradation in celery rhizosphere and non-rhizosphere soil were studied with rhizobag technique.The results showed that bacterial numbers were inhibited by metolachlor initially,but increased after 7 d.Fungi numbers were stimulated by metolachlor,and the higher the metolachlor concentration the greater the influence,which indicated that fungi can utilize metolachlor as carbon and energy sources.Both bacteria and fungi numbers in rhizosphere were higher than those in non-rhizosphere soil.The degradation of metolachlor in soil followed first-order kinetics.Half lives(t1/2)of metolachlor at 1 mg\u00b7kg-1,2.5 mg\u00b7kg-1 and 5 mg\u00b7kg-1 in rhizosphere were shorted to be 86.22%,78.95% and 77.97% of those in non-rhizosphere soils,their corresponding degradation rates were 1.16,1.27 and 1.28 times of those in non-rhizosphere soils,respectively.The results indicated that degradation of metolachlor was stimulated by plant roots in rhizosphere.Plants and their associated rhizosphere microorganisms could be a good method for bioremediation of soils contaminated with organic pollutants.",
        "keywords": [
            "degradation",
            "soil microorganism",
            "rhizosphere",
            "metolachlor"
        ],
        "authors": [
            {
                "name": "CHEN Bo",
                "org": "Yuhang Environmental Monitoring Station,Hangzhou ,China"
            },
            {
                "name": "XU Dong-mei",
                "org": "Institute of Environmental Science,Zhejiang University,Hangzhou ,China"
            },
            {
                "name": "WU Jun-lin",
                "org": "Shangyu Environmental Protection Bureau,Shangyu ,China"
            },
            {
                "name": "LIU Guang-shen",
                "org": "Institute of Environmental Science,Zhejiang University,Hangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Institute of Environmental Science,Zhejiang University,Hangzhou ,China;Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou ,China"
            }
        ],
        "venue": "Journal of Agro-Environment Science",
        "year": 2006
    },
    "euKzkaR9": {
        "id": "euKzkaR9",
        "title": "Arsenic in agricultural soils across China: Distribution pattern, accumulation trend, influencing factors, and risk assessment.",
        "abstract": "Arsenic (As) in the environment is of concern due to its strong toxicity and high risks to the ecosystems and humans. In this study, soil samples across China collected in 2011 and 2016 were used to determine the concentrations of arsenic in arable soils. The median concentration of arsenic in surface soils was 9.7mg/kg. The inventory of arsenic in the Chinese agricultural surface soils was estimated to be 3.7\u00d710tons. In general, arsenic contamination was found higher in South and Northeast China than in other regions, with means of 18.7 and 15.8mg/kg, respectively. Vertically, arsenic concentrations were higher in top layer (0-15cm) soils (median of 9.8mg/kg) and decreased with soil depth (medians of 8.9mg/kg at 15-30cm and 8.0mg/kg at 30-45cm). By comparing with published data, an increasing accumulation trend over the past decades was found and this enhancement was positively related with the long-term application of fertilizers in agricultural practice, especially phosphate fertilizers. Soil pH was found to affect the movement of arsenic in soil, and high-pH conditions enhanced the pool of arsenic. The ecological risk assessment revealed that arsenic in Chinese agricultural soil posed a low risk to the ecosystem. Regarding human health, the mean hazard indices (HIs) of arsenic were below 1, suggesting an absence of non-carcinogenic risks. In addition, the cancer risks of arsenic in all soil samples were within the acceptable range (below 1\u00d710), indicating low to very low risks to the exposed population. Findings from this study are valuable to provide effective management options for risk avoidance and to control the persistent accumulation of arsenic in the agriculture sector across the world.",
        "keywords": [
            "Accumulation trend",
            "Agricultural soil",
            "Arsenic",
            "Distribution pattern",
            "Ecological and human health risk"
        ],
        "authors": [
            {
                "name": "Yuting Zhou",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Lili Niu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Kai Liu",
                "org": "Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: kliu7@caltech.edu."
            },
            {
                "name": "Shanshan Yin",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Weiping Liu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: wliu@zju.edu."
            }
        ],
        "venue": "The Science of the total environment",
        "year": 2018
    },
    "vJ8maFzt": {
        "id": "vJ8maFzt",
        "title": "Relationships of Pyrethroid Exposure with Gonadotropin Levels and Pubertal Development in Chinese Boys.",
        "abstract": "Although an acceleration of male pubertal development has been observed, precisely which endocrine-disrupting chemicals (EDCs) might contribute to the advancing onset of puberty in boys remains unclear. Here, pyrethroids, a class of widely used insecticides that have been considered as EDCs, are proposed as new environmental risk factors. In this study, 463 boys at the age of 9-16 years old were recruited in Hangzhou, Zhejiang, China. The common metabolites of pyrethroids, 3-phenoxybenzoic acid (3-PBA), and 4-fluoro-3-phenoxybenzoic acid (4-F-3-PBA), as well as gonadotropins, including luteinizing hormone (LH) and follicle-stimulating hormone (FSH), were analyzed in urine samples. Pubertal development was assessed based on Tanner stages and testicular volume (TV). A positive association between 3-PBA and gonadotropins was found (p < 0.001), in which a 10% increase in 3-PBA was associated with a 2.4% and 2.9% increase in LH and FSH, respectively. Higher urinary levels of 3-PBA in boys were associated with 275% and 280% increase in the risk of being genitalia stage 3 (G3) and G4, respectively (p < 0.05). There was a significant (132%) induction in odd of being TV 12-19 mL with increasing 3-PBA concentration compared to being in TV < 4 mL (p < 0.05). For the first time to our knowledge, this work reports on an association of increased pyrethroid exposure with elevated gonadotropins levels and earlier pubertal development in boys.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaoqing Ye",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, \u2021Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, and \u00a7School of Public Health, Zhejiang University , Hangzhou 310058, China."
            },
            {
                "name": "Wuye Pan",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, \u2021Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, and \u00a7School of Public Health, Zhejiang University , Hangzhou 310058, China."
            },
            {
                "name": "Shilin Zhao",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, \u2021Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, and \u00a7School of Public Health, Zhejiang University , Hangzhou 310058, China."
            },
            {
                "name": "Yuehao Zhao",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, \u2021Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, and \u00a7School of Public Health, Zhejiang University , Hangzhou 310058, China."
            },
            {
                "name": "Yimin Zhu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, \u2021Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, and \u00a7School of Public Health, Zhejiang University , Hangzhou 310058, China."
            },
            {
                "name": "Jing Liu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, \u2021Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, and \u00a7School of Public Health, Zhejiang University , Hangzhou 310058, China."
            },
            {
                "name": "Weiping Liu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, \u2021Research Center for Air Pollution and Health, College of Environmental and Resource Sciences, and \u00a7School of Public Health, Zhejiang University , Hangzhou 310058, China."
            }
        ],
        "venue": "Environmental science & technology",
        "year": 2017
    },
    "fuoGts1E": {
        "id": "fuoGts1E",
        "title": "Effects of copper sulfate, hydrogen peroxide and N-phenyl-2-naphthylamine on oxidative stress and the expression of genes involved photosynthesis and microcystin disposition in Microcystis aeruginosa.",
        "abstract": "Algal blooms have been increasing in prevalence all over the world, destroying ecosystems and placing other organisms at risk. Chemical remediation is one of most important methods of controlling algal bloom formation. The effects of copper sulfate, hydrogen peroxide (H(2)O(2)) and N-phenyl-2-naphthylamine on photosynthesis-related and microcystin-related gene transcription and physiological changes of Microcystis aeruginosa were analyzed. The results suggest that transcription of psaB, psbD1 and rbcL was inhibited by the three algaecides, which blocked the electron transport chain, significantly enhanced reactive oxygen species (ROS) accumulation and overwhelmed the antioxidant system. The increase in ROS destroyed pigment synthesis and membrane integrity, which inhibited or killed the algal cells. Furthermore, H(2)O(2) treatment down-regulated mcyD transcription, which indicated a decrease in the microcystin level in the cells. Our results demonstrate that H(2)O(2) has the greatest potential as an algaecide because it not only inhibits algae growth but may reduce microcystin synthesis.",
        "keywords": [
            "toxicity",
            "microcystis aeruginosa",
            "pna",
            "h 2 o 2",
            "cuso 4",
            "gene transcription",
            "algal bloom",
            "electron transport chain",
            "hydrogen peroxide"
        ],
        "authors": [
            {
                "name": "Haifeng Qian",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang, 310032, China"
            },
            {
                "name": "Shuqiong Yu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang, 310032, China"
            },
            {
                "name": "Zhengqi Sun",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang, 310032, China"
            },
            {
                "name": "Xiucai Xie",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang, 310032, China"
            },
            {
                "name": "Weiping Liu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang, 310032, China"
            },
            {
                "name": "Zhengwei Fu",
                "org": ""
            }
        ],
        "venue": "Aquatic toxicology (Amsterdam, Netherlands)",
        "year": 2010
    },
    "SJqCacVS": {
        "id": "SJqCacVS",
        "title": "Enantioselective Damage of Diclofop Acid Mediated by Oxidative Stress and Acetyl-CoA Carboxylase in Nontarget Plant Arabidopsis thaliana",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "meirong zhao",
                "org": ""
            },
            {
                "name": "haifeng qian",
                "org": ""
            },
            {
                "name": "tao lu",
                "org": ""
            },
            {
                "name": "quan zhang",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            }
        ],
        "venue": "Environmental Science & Technology",
        "year": 2012
    },
    "HzEdvxsK": {
        "id": "HzEdvxsK",
        "title": "Elucidation of the Enantioselective Enzymatic Hydrolysis of Chiral Herbicide Dichlorprop Methyl by Chemical Modification",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "shulin zhuang",
                "org": ""
            },
            {
                "name": "zhaohua fang",
                "org": ""
            },
            {
                "name": "chandan li",
                "org": ""
            },
            {
                "name": "yuezhong wen",
                "org": ""
            }
        ],
        "venue": "Journal of Agricultural and Food Chemistry",
        "year": 2011
    },
    "3NDa6q6c": {
        "id": "3NDa6q6c",
        "title": "Research on the present pollution situation and advanced oxidation degradation of phthalate esters in water",
        "abstract": "The sources,toxicity and the pollution control measures of the phthalate esters are introduced.The present pollution situation of phthalate esters in some water sources and the effluent water from waterworks in China are investigated.Aiming at the characteristics of its low concentration and high toxicity in the water environment,the research progress and degradation mechanisms of the most effective and advanced oxidation processes-chemical oxidation process and photodegradation process for treating such substances,are summarized.",
        "keywords": [
            "phthalate esters",
            "photodegradation technology",
            "chemical oxidation"
        ],
        "authors": [
            {
                "name": "Wang Junliang",
                "org": "College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "Xu Chao",
                "org": "College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "Zhuang Xiaowei",
                "org": "Zhejiang Provincial Key Laboratory of Biological and Chemical Utilization of Forest Resource, Zhejiang Forestry Academy,Hangzhou ,China"
            },
            {
                "name": "Liu Weiping",
                "org": "College of Biological and Environmental Engineering,Zhejiang University of Technology,Hangzhou ,China"
            }
        ],
        "venue": "Industrial Water Treatment",
        "year": 2011
    },
    "csVqKyEe": {
        "id": "csVqKyEe",
        "title": "Hexachlorocyclohexane exposure alters the microbiome of colostrum in Chinese breastfeeding mothers.",
        "abstract": "Breast milk, especially colostrum, is not just a source of nutrients and immune factors for the newborn, but also accumulates environmental persistent pollutants and its diverse microbes affect the early colonization of the newborn's gut. Little is known about associations between environmental pollutants and the microbial composition of human colostrum. We assessed the influence of hexachlorocyclohexane (HCH), a persistent organic pollutant (POP), in colostrums on the microbial composition of human colostrum samples. HCH concentrations in 89 colostrum samples collected from a population living on the easternmost island of China were measured via gas chromatography equipped with mass spectrometer (GC-MS), HCH exposure risks for infants via dietary intake of breast milk were assessed, and for 29 colostrum samples the microbiota were profiled using 16S rRNA gene pyrosequencing to assess the association with HCH exposure levels. Our study confirmed high colostrum exposure levels of total HCHs (12.19\u202f\u00b1\u202f13.68\u202f\u03bcg\u202fL) in this Chinese population. We predominantly identified Proteobacteria (67.6%) and Firmicutes (25.1%) in colostrum and microbial diversity at the genus level differed between samples with different HCH levels; e.g., Pseudomonas which contains several HCH degrading strains was found in significantly higher abundance in \u03b3-HCH rich samples. Also, microbes that were statistically significantly associated with HCH levels were also highly correlated with each other (false discovery rate (FDR)\uff1c0.01) and clustered in network analysis. Microbial diversity is associated with HCH levels in human colostrum and these associations might be attributable to their HCH degrading ability. These finding provide first insights into the role that environmental persistent pollutants may play in the microbial composition of human colostrum and the colonization of the infant gut.",
        "keywords": [
            "Breast milk microbiota",
            "Colostrum",
            "Hexachlorocyclohexane",
            "Microbiome",
            "Pollution exposure"
        ],
        "authors": [
            {
                "name": "Mengling Tang",
                "org": "Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, CA, USA."
            },
            {
                "name": "Chenye Xu",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation & Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang, China."
            },
            {
                "name": "Kun Chen",
                "org": "Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China."
            },
            {
                "name": "Qi Yan",
                "org": "Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, CA, USA."
            },
            {
                "name": "Weihua Mao",
                "org": "Analysis Center of Agrobiology and Environmental Sciences, Zhejiang University, Hangzhou, Zhejiang, China."
            },
            {
                "name": "Weiping Liu",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation & Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang, China. Electronic address: wliu@zju.edu.cn."
            },
            {
                "name": "Beate Ritz",
                "org": "Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, CA, USA."
            }
        ],
        "venue": "Environmental pollution (Barking, Essex : 1987)",
        "year": 2019
    },
    "2q54r8yw": {
        "id": "2q54r8yw",
        "title": "The chemodiversity of paddy soil dissolved organic matter correlates with microbial community at continental scales.",
        "abstract": "Our study demonstrates the continental-scale distribution of DOM is significantly correlated with the taxonomic profile and metabolic potential of the rice paddy microbiome. Abiotic factors that have a distinct effect on community structure can also influence the chemodiversity of DOM and vice versa. Deciphering these associations and the underlying mechanisms can precipitate understanding of the complex ecology of paddy soils, as well as help assess the effects of human activities on biogeochemistry and greenhouse gas emissions in paddy soils.",
        "keywords": [
            "Chemodiversity",
            "Dissolved organic matter",
            "FT-ICR-MS",
            "Microbial diversity",
            "Paddy soil"
        ],
        "authors": [
            {
                "name": "Hong-Yi Li",
                "org": "College of Environment and Natural Resource Sciences, Zhejiang University, 866 Yuhangtang Ave, Hangzhou, 310058, China."
            },
            {
                "name": "Hang Wang",
                "org": "National Plateau Wetlands Research Center, Southwest Forestry University, 300 Bailongsi, Kunming, 650224, China."
            },
            {
                "name": "Hai-Tiao Wang",
                "org": "Department of Surgery, University of Chicago, 5640 South Ellis Avenue, Chicago, IL, 60637, USA."
            },
            {
                "name": "Pei-Yong Xin",
                "org": "National Center of Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, West Beichen Road, Chaoyang District, Beijing, 100101, China."
            },
            {
                "name": "Xin-Hua Xu",
                "org": "College of Environment and Natural Resource Sciences, Zhejiang University, 866 Yuhangtang Ave, Hangzhou, 310058, China."
            },
            {
                "name": "Yun Ma",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, 18 Chaowang Ave, Hangzhou, 310014, China."
            },
            {
                "name": "Wei-Ping Liu",
                "org": "College of Environment and Natural Resource Sciences, Zhejiang University, 866 Yuhangtang Ave, Hangzhou, 310058, China."
            },
            {
                "name": "Chang-Yun Teng",
                "org": "Hangzhou Gusheng Agricultural Technology Company Limited, Chongxian Innovation Industrial Park, Chongxian Ave, Hangzhou, 311108, China."
            },
            {
                "name": "Cheng-Liang Jiang",
                "org": "Hangzhou Gusheng Agricultural Technology Company Limited, Chongxian Innovation Industrial Park, Chongxian Ave, Hangzhou, 311108, China."
            },
            {
                "name": "Li-Ping Lou",
                "org": "College of Environment and Natural Resource Sciences, Zhejiang University, 866 Yuhangtang Ave, Hangzhou, 310058, China."
            },
            {
                "name": "Wyatt Arnold",
                "org": "Department of Surgery, University of Chicago, 5640 South Ellis Avenue, Chicago, IL, 60637, USA."
            },
            {
                "name": "Lauren Cralle",
                "org": "Department of Surgery, University of Chicago, 5640 South Ellis Avenue, Chicago, IL, 60637, USA."
            },
            {
                "name": "Yong-Guan Zhu",
                "org": "Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, 1799 Jimei Ave, Xiamen, 361021, China."
            },
            {
                "name": "Jin-Fang Chu",
                "org": "National Center of Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, West Beichen Road, Chaoyang District, Beijing, 100101, China."
            },
            {
                "name": "Jack A Gilbert",
                "org": "Department of Surgery, University of Chicago, 5640 South Ellis Avenue, Chicago, IL, 60637, USA. gilbertjack@uchicgao.edu."
            },
            {
                "name": "Zhi-Jian Zhang",
                "org": "China Academy of West Region Development, Zhejiang University, 866 Yuhangtang Ave, Hangzhou, 310058, China. zhangzhijian@zju.edu.cn."
            }
        ],
        "venue": "Microbiome",
        "year": 2018
    },
    "SBmkwJ9p": {
        "id": "SBmkwJ9p",
        "title": "Histopathological and proteomic analysis of hepatic tissue from adult male zebrafish exposed to 17\u03b2-estradiol.",
        "abstract": "17\u03b2-Estradiol (E2) is known to contribute significantly a large extent to the estrogenicity in aquatic system. In the present study, two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MALDI-TOF-TOF MS), combined with histopathological analysis, was used to screen hepatic responses in adult male zebrafish. Eight proteins were found to be up-regulated more than 2-fold, whereas five protein spots were down-regulated more than 2-fold after 1nM E2 treatment for 14 days, which had caused histological effects in zebrafish livers. These differentially expressed proteins accounted for a variety of cellular biological processes, such as response to oxidative stress, cell surface receptor-linked signal transduction, oxidation-reduction and cellular calcium ion homeostasis. The results demonstrated that E2 comprehensively influenced a variety of cellular and biological processes in zebrafish. Moreover, the proteomic responses elicited in zebrafish allow us to better understand the underlying mechanisms of endocrine-disrupting chemicals (EDCs)-induced toxicity fully.",
        "keywords": [
            "zebrafish",
            "endocrine disrupting effects",
            "proteome",
            "17\u03b2-estradiol",
            "liver",
            "two dimensional gel electrophoresis",
            "biological process",
            "mass spectrometry",
            "signal transduction"
        ],
        "authors": [
            {
                "name": "Yuanxiang Jin",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Xiangxiang Zhang",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Dezhao Lu",
                "org": "College of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, China"
            },
            {
                "name": "Liwei Sun",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Haifeng Qian",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Weiping Liu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Zhengwei Fu",
                "org": ""
            }
        ],
        "venue": "Environmental toxicology and pharmacology",
        "year": 2010
    },
    "voahHUAb": {
        "id": "voahHUAb",
        "title": "The circadian clock gene regulatory module enantioselectively mediates imazethapyr-induced early flowering in Arabidopsis thaliana.",
        "abstract": "Plant growth and development are strongly affected by environmental pollutants, such as herbicides. Widely used herbicides can remain in soil or aquatic systems for long periods of time. Herbicide pollutants have been reported to heavily affect global plant growth and pose a significant challenge to agriculture. However, it is unclear whether herbicides affect plant flowering. Here, we demonstrated that imazethapyr (IM), a chiral herbicide, can enantioselectively promote flowering in Arabidopsis thaliana. We clarified the possible mechanism by which IM promotes flowering and found that the photoperiod pathway may play an important role in propagating the IM stress signal. IM enantiomers decreased the amplitude of core oscillators (CIRCADIAN CLOCK ASSOCIATED 1 and LATE ELONGATED HYPOCOTYL) and utilized the up-regulation of the GIGANTEA-(CONSTANS)-FLOWERING LOCUS T pathway to induce floral gene, APETALA1 over-expression enantioselectively; this treatment ultimately caused early flowering. Our findings provide new insight into the method by which plants control reproductive timing in response to herbicide stress. Flowering time is an important trait in crops and affects the life cycles of pollinator species. The persistence of herbicides in the biosphere will alter plant life cycles and diversity.",
        "keywords": [
            "arabidopsis thaliana",
            "clock genes",
            "flowering",
            "imazethapyr",
            "photoperiod pathway"
        ],
        "authors": [
            {
                "name": "Haifeng Qian",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, People's Republic of China."
            },
            {
                "name": "Xiao Han",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, People's Republic of China."
            },
            {
                "name": "Xiaofeng Peng",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, People's Republic of China."
            },
            {
                "name": "Tao Lu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, People's Republic of China."
            },
            {
                "name": "Weiping Liu",
                "org": "College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, People's Republic of China."
            },
            {
                "name": "Zhengwei Fu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, People's Republic of China."
            }
        ],
        "venue": "Journal of plant physiology",
        "year": 2014
    },
    "574HzX5t": {
        "id": "574HzX5t",
        "title": "Functional identification of two novel genes from Pseudomonas sp. strain HZN6 involved in the catabolism of nicotine.",
        "abstract": "Nicotine is a natural alkaloid produced by tobacco plants, and the mechanisms of its catabolism by microorganisms are diverse. In the present study, we reported the mutation, cloning, and identification of two novel genes involved in nicotine degradation from the newly isolated Pseudomonas sp. strain HZN6. Transposon mutagenesis identified a HZN6 mutant in which the nicotine-degrading pathway was blocked at pseudooxynicotine. A 3,874-bp DNA fragment flanking the transposon insertion site was obtained through self-formed adaptor PCR. Two open reading frames (designated pao and sap) were analyzed, and the deduced amino acid sequences shared 29% identity with 6-hydroxy-l-nicotine oxidase from Arthrobacter nicotinovorans and 49% identity with an aldehyde dehydrogenase from Bartonella henselae. Both pao and sap were cloned and functionally expressed in recombinant Escherichia coli BL21. The pao gene encoded a novel pseudooxynicotine amine oxidase with noncovalently bound flavin adenine dinucleotide (FAD) and exhibited substrate specificity removing the methylamine from pseudooxynicotine with the formation of 3-succinoylsemialdehyde-pyridine and hydrogen dioxide. The sap gene encoded a NADP(+)-dependent 3-succinoylsemialdehyde-pyridine dehydrogenase that catalyzed the dehydrogenation of 3-succinoylsemialdehyde-pyridine to 3-succinoyl-pyridine. Genetic analyses indicated that the pao gene played an essential role in nicotine or pseudooxynicotine mineralization in strain HZN6, whereas the sap gene did not. This study provides novel insight into the nicotine-degrading mechanism at the genetic level in Pseudomonas spp.",
        "keywords": [],
        "authors": [
            {
                "name": "Jiguo Qiu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Yun Ma",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Yuezhong Wen",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Liansheng Chen",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Lifei Wu",
                "org": "Zhejiang University of Technology(Zhejiang University of Technology),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Applied and environmental microbiology",
        "year": 2012
    },
    "zbwLlGCK": {
        "id": "zbwLlGCK",
        "title": "Toxic effects of trace elements on newborns and their birth outcomes.",
        "abstract": "Some trace elements are essential for newborns, their deficiency may cause abnormal biological functions, whereas excessive intakes due to environmental contamination may create adverse health effects. This study was conducted to measure the levels of selected trace elements in Chinese fish consumers by assessing their essentiality and toxicity via colostrum intake in newborns, and evaluated the effects of these trace elements on birth outcomes. Trace elements in umbilical cord serum and colostrum of the studied population were relatively high compared with other populations. The geometric means (GM) of estimated daily intake (EDI, mgday(-1)) of the trace elements were in the safe ranges for infant Dietary Reference Intakes (DRIs) recommended by the United States Food and Drug Administration (FDA). When using total dietary intake (TDI, mgkg(-1)bwday(-1)), zinc (Zn) (0.880mgkg(-1)bwday(-1)) and selenium (Se) (6.39\u00d710(-3)mgkg(-1)bwday(-1)) were above the Reference Doses (RfD), set by the United States Environmental Protection Agency (EPA). Multivariable linear regression analyses showed that Se was negatively correlated with birth outcomes. Our findings suggested that overloading of trace elements due to environmental contamination may contribute to negative birth outcomes.",
        "keywords": [
            "Birth outcomes",
            "Fish consumers",
            "Toxicity",
            "Trace elements"
        ],
        "authors": [
            {
                "name": "Mengling Tang",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation &amp; Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China."
            },
            {
                "name": "Chenye Xu",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation &amp; Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China."
            },
            {
                "name": "Nan Lin",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation &amp; Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China."
            },
            {
                "name": "Shanshan Yin",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation &amp; Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China."
            },
            {
                "name": "Yongli Zhang",
                "org": "Zhoushan Municipal for Disease Control and Prevention, Key Laboratory of Health Risk Factors for Seafood of Zhejiang Province, 386 Wenshan Road, Zhoushan, China."
            },
            {
                "name": "Xinwei Yu",
                "org": "Zhoushan Municipal for Disease Control and Prevention, Key Laboratory of Health Risk Factors for Seafood of Zhejiang Province, 386 Wenshan Road, Zhoushan, China."
            },
            {
                "name": "Weiping Liu",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation &amp; Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China."
            }
        ],
        "venue": "The Science of the total environment",
        "year": 2016
    },
    "gqUjPOE9": {
        "id": "gqUjPOE9",
        "title": "Enantioselective environmental toxicology of chiral pesticides.",
        "abstract": "The enantioselective environmental toxic effect of chiral pesticides is becoming more important. As the industry develops, increasing numbers of chiral insecticides and herbicides will be introduced into use, potentially posing toxic effects on nontarget living beings. Chiral pesticides, including herbicides such as acylanilides, phenoxypropanoic acids, and imidazolinones, and insecticides such as synthetic pyrethroids, organophosphates, and DDT often behave enantioselectively during agricultural use. These compounds also pose unpredictable enantioselective ecological threats to nontarget living beings and/or humans, affecting the food chain and entire ecosystems. Thus, to investigate the enantioselective toxic effects of chiral insecticides and herbicides is necessary during environmental protection. The environmental toxicology of chiral pesticides, especially the findings obtained from studies conducted in our laboratory during the past 10 years, is reviewed.",
        "keywords": [],
        "authors": [
            {
                "name": "Jing Ye",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, Institute of Environmental Sciences, College of Environmental and Resource Sciences, Zhejiang University , Hangzhou 310058, China."
            },
            {
                "name": "Meirong Zhao",
                "org": ""
            },
            {
                "name": "Lili Niu",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            }
        ],
        "venue": "Chemical research in toxicology",
        "year": 2015
    },
    "wuCgwIgS": {
        "id": "wuCgwIgS",
        "title": "Oxidative stress response and gene expression with atrazine exposure in adult female zebrafish (Danio rerio).",
        "abstract": "Atrazine (ATZ) is the most common pesticide of freshwater ecosystems in the world. The effects of ATZ exposure on the induction of oxidative stress and the alteration of gene expression were studied in liver and ovary samples from female zebrafish (Danio rerio). Antioxidant enzyme activities (SOD and CAT), in addition to the GSH and MDA content, in the liver altered significantly; the mRNA levels for the genes encoding these antioxidant proteins, such as Cu/Zn-Sod, Mn-Sod, Cat, and Gpx, were up-regulated significantly in the liver when zebrafish were exposed to various concentrations of ATZ for 14d. However, the mRNA induction patterns were not in accordance with those of antioxidant enzyme changes in the liver and ovary. Moreover, the transcriptional expression of mitochondrial inner membrane genes related to ROS production, such as Ucp-2 and Bcl-2, were altered significantly in high ATZ treatment groups. However, the ATZ treatment did not induce any apparent changes in the transcriptional expression of CoxI, Ndi, or ATPo6, which are related to the mitochondrial respiratory chain and ATP synthesis. To our knowledge, this is the first report to study the transcriptional effects of ATZ stress on zebrafish. The information presented in this study will be helpful in fully understanding the mechanism of oxidative stress induced by ATZ in fish.",
        "keywords": [
            "female zebrafish",
            "real-time rt-pcr",
            "oxidative stress",
            "atrazine"
        ],
        "authors": [
            {
                "name": "Yuanxiang Jin",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Xiangxiang Zhang",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Linjun Shu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Lifang Chen",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Liwei Sun",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Haifeng Qian",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Weiping Liu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China"
            },
            {
                "name": "Zhengwei Fu",
                "org": ""
            }
        ],
        "venue": "Chemosphere",
        "year": 2010
    },
    "Fc5maVmQ": {
        "id": "Fc5maVmQ",
        "title": "Sensitive determination of DNA based on the interaction between norfloxacin-Tb3+ complex and DNA.",
        "abstract": "The fluorescence intensity of the norfloxacin (NFX)-Tb3+ complex enhanced by DNA was studied. Therefore, a sensitive fluorescence method for the determination of DNA was developed. The optimal conditions of the method were as follows: the hexamethylenamine (HMA)-HCl buffer was adopted for adjusting the pH to 6.5 +/- 0.1, the concentrations of NFX and Tb3+ were both fixed in 1.0 x 10(-6) mol L(-1), and the excitation and emission wavelengths were selected at 290 and 545 nm, respectively. Under the optimal conditions, the enhanced fluorescence intensity was in proportion to the concentration of DNA in the same range of 5.0 x 10(-9) - 1.0 x 10(-6) g mL(-1) for hsDNA and thermally denatured ctDNA. The detection limits (S/N = 3) were 0.9 and 0.6 ng mL(-1), respectively. In addition, the interaction between NFX-Tb3+ and DNA was discussed in detail. The experimental results from UV absorption spectra, fluorescence spectra, and the salt effect study indicated that the interaction between norfloxacin-Tb3+ complex and DNA had at least two different binding modes: the electrostatic binding and the intercalation binding. The mechanism of the fluorescence enhancement effect was also discussed.",
        "keywords": [
            "dna",
            "fluorimetry",
            "interaction",
            "nfx-tb3+ complex"
        ],
        "authors": [
            {
                "name": "Changlun Tong",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Zhou Hu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Weiping Liu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Journal of agricultural and food chemistry",
        "year": 2005
    },
    "UA9Bm8ES": {
        "id": "UA9Bm8ES",
        "title": "Enantiomeric resolution and biotoxicity of methamidophos.",
        "abstract": "Despite the fact that the biological processes of chiral pesticides are enantioselective, the biotoxicity of methamidophos with respect to enantioselectivity has so far received limited research. In this study, the enantiomeric separation and biotoxicity of the two enantiomers of methamidophos were investigated. Successful enantioseparation of methamidophos using high-performance liquid chromatography on a Chiralcel OD column was achieved. As indicated by the optical rotation and circular dichroism detection, (+)-methamidophos was eluted prior to (-)-methamidophos. The t test at the 95% level of confidence indicated significant differences between the enantiomers in their in vitro inhibition toward acetylcholinesterases of bovine erythrocytes and Electrophorus electricus and in vivo acute aquatic toxicity to Daphnia magna. The in vitro assays showed that (-)-methamidophos was about 8.0-12.4 times more potent to the enzymes than its (+)-form. In contrast, the (+)-enantiomer was 7.0 times more toxic to D. magna in 48 h tests. The toxicity of racemic methamidophos was intermediate in both in vitro and in vivo bioassays. These results suggest that the biotoxicity of chiral OPs to nontargeted organisms is enantioselective and therefore should be reevaluated with their pure enantiomers.",
        "keywords": [
            "chiral pesticide",
            "enantiomeric separation",
            "enantioselective toxicity",
            "methamidophos"
        ],
        "authors": [
            {
                "name": "Kunde Lin",
                "org": ""
            },
            {
                "name": "Shanshan Zhou",
                "org": ""
            },
            {
                "name": "Chao Xu",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            }
        ],
        "venue": "Journal of agricultural and food chemistry",
        "year": 2006
    },
    "08C0oIu7": {
        "id": "08C0oIu7",
        "title": "Biosorption and degradation of acetofenate by algae",
        "abstract": "This work investigates the sorption and degradation of acetofenate,a toxic and persistent organochlorine pesticide by Chlorella pyrenoidosa and Anabaena flosaquae.We study the effects of biodegradation,biosorption,hydrolysis and photolysis on the process of reducing acetofenate.In the degradation process,acetofenate was rapidly degraded by both the algae,suggesting its initial removal from water was mainly by biodegradation.The degradation half-life(T1/2) of acetofenate was about 16 h,and the biosorption of acetofenate by the two algae was also obvious,although after some times the effect of absorption would be appeared to level off,due to the coagulate effect of algae cell.Sum up,the biodegradation and biosorption effects were main reasons for reducing pesticides,the hydrolysis effect was feeblish and the photolysis of acetofenate was negligible under the used experimental conditions.These results suggest that Chlorella pyrenoidosa and Anabaena flosaquae were able to continuously detoxify acetofenate.",
        "keywords": [
            "sorption",
            "degradation",
            "alga",
            "acetofenate",
            "hydrolysis"
        ],
        "authors": [
            {
                "name": "TU Yun-jie",
                "org": "Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "MA Yun",
                "org": "Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou ,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": "Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou ,China"
            }
        ],
        "venue": "Journal of Zhejiang University of Technology",
        "year": 2009
    },
    "2zvcr8LA": {
        "id": "2zvcr8LA",
        "title": "Prenatal exposure to polychlorinated biphenyl and umbilical cord hormones and birth outcomes in an island population.",
        "abstract": "Prenatal exposure to polychlorinated biphenyl (PCB) is suspected to interfere with fetal development including reproductive and thyroid function and birth outcomes, but published evidence are still sparse. We designed a cross-sectional study to analyze the associations between PCB levels in umbilical cord sera and hormones and birth outcomes of mothers and newborns who are residents from an island. Seven indicator-PCB (PCB-28, 52, 101, 118, 138, 153, 180), and five reproductive hormones including luteotropic hormones (LH), estradiol (E2), testosterone (T), follicle-stimulating hormones (FSH) and anti-Mullerian hormones (AMH), and three thyroid hormones including tri-iodothyronine (T3), tetra-iodothyronine (T4) and thyroid stimulating hormones (TSH) were measured in 106 cord sera specimens. Birth outcomes include birth weight, length, head circumference, and gestational age. Multiple linear regression and quartile regression were used to analyze the associations between PCB and each of the hormones and birth outcomes, adjusting for selected potential confounders. The median value of total PCB in umbilical cord sera was 2.02\u202f\u03bcg\u202fL (IQR, 1.13-4.64). Several negative associations between PCB exposure and reproductive hormones were found. Among them, the \u03b2 value of PCB-101 for FSH reached\u00a0-0.38 (95%CI,\u00a0-0.69,\u00a0-0.07; p\u202f=\u202f0.02). Moreover, we also found some sex-specific associations i.e. PCB-28 was negatively correlated with LH and T and PCB-118 was negatively correlated with T in male newborns but not in female newborns. The associations between PCB and birth outcomes seem to differ by molecular weight of the PCB congeners i.e. the low-chlorinated PCB congeners were negatively associated with gestational age and head circumference while high-chlorinated PCB congeners were positively associated birth weight and gestational age. In this study, we found that PCB congeners with different molecular weight has different associations with hormones and birth outcomes, and future studies are recommended to investigate underlying mechanisms of these associations.",
        "keywords": [
            "Birth outcomes",
            "Polychlorinated biphenyl",
            "Reproductive hormones",
            "Thyroid hormones"
        ],
        "authors": [
            {
                "name": "Mengling Tang",
                "org": "Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou, China."
            },
            {
                "name": "Shanshan Yin",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation & Ecosystem Health, College of Environmental and Research Sciences, Zhejiang University, Hangzhou, China."
            },
            {
                "name": "Jianyun Zhang",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation & Ecosystem Health, College of Environmental and Research Sciences, Zhejiang University, Hangzhou, China."
            },
            {
                "name": "Kun Chen",
                "org": "Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou, China."
            },
            {
                "name": "Mingjuan Jin",
                "org": "Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou, China."
            },
            {
                "name": "Weiping Liu",
                "org": "Ministry of Education Key Laboratory of Environmental Remediation & Ecosystem Health, College of Environmental and Research Sciences, Zhejiang University, Hangzhou, China. Electronic address: wliu@zju.edu.cn."
            }
        ],
        "venue": "Environmental pollution (Barking, Essex : 1987)",
        "year": 2018
    },
    "oh6sGSU0": {
        "id": "oh6sGSU0",
        "title": "CHIRAL DETECTORS AND CHARACTERIZATION WITH CIRCULAR DICHROISM OF CHIRAL PESTICIDES",
        "abstract": "This paper introduced the principles of optical rotatory dispersion(ORD) and circular dichroism(CD) chiral detectors,and also discussed the relationship between ORD,CD and ultraviolet detector(UV).Comparing ORD with CD,it was clearly indicated that the characterization of enantiomers with CD was better than that with ORD.Cotton effect was suggested to describe the absolute configuration of enantiomer.",
        "keywords": [
            "chiral pesticide.",
            "cotton effect",
            "circular dichroism",
            "optical rotatory dispersion"
        ],
        "authors": [
            {
                "name": "CHEN Sheng-wen",
                "org": " Institute of Environmental Science,Zhejiang University,Hangzhou,,China"
            },
            {
                "name": "LIU Wei-ping",
                "org": " Institute of Environmental Science,Zhejiang University,Hangzhou,,China; Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou,,China"
            },
            {
                "name": "ZHANG Da-tong",
                "org": " Research Center of Environmental Science,Zhejiang University of Technology,Hangzhou,,China"
            }
        ],
        "venue": "Environmental Chemistry",
        "year": 2006
    },
    "cCZv3YJ5": {
        "id": "cCZv3YJ5",
        "title": "Induction of macrophage apoptosis by an organochlorine insecticide acetofenate.",
        "abstract": "Acetofenate (AF) is a widely used insecticide in China and other regions of southeastern Asia. A previous study showed that AF caused adverse developmental effects in zebrafish. Macrophages, which play a key role in inflammation, host defense, and reactions against a spectrum of autologous and foreign invaders, are crucial for innate immunity. However, cytotoxicity and apoptosis of macrophages caused by organochlorine pesticides (OCPs) have so far received little attention. In this study, we used AF as a model chemical to investigate the cytotoxic effects of OCPs on mouse macrophage cell line RAW264.7. Results from cell viability and apoptosis assays showed that AF induced apparent apoptosis in RAW 264.7 cells. Furthermore, AF induced intracellular reactive oxygen species (ROS) generation and DNA damage and resulted in the alteration of a series of signaling molecules including up-regulation of p53 and cytochrome c protein levels, decline of the Bcl-2/Bax protein ratio, and activation of the caspases cascade through caspase-9 and caspase-3. These results, for the first time, revealed that the increase of endogenous ROS and DNA damage comediating OCP-induced apoptosis in macrophages may be by the mitochondria and p53 signal pathway. Our results suggested that macrophages are involved in AF-induced adverse immune effects. Considering the ubiquitous environmental presence of OCPs, this study provided new information on the potential long-term physiological and immunological effects due to chronic exposures to OCPs.",
        "keywords": [
            "cytotoxicity",
            "apoptosis",
            "cell lines",
            "adverse effects",
            "in vitro"
        ],
        "authors": [
            {
                "name": "Meirong Zhao",
                "org": ""
            },
            {
                "name": "Ying Zhang",
                "org": ""
            },
            {
                "name": "Cui Wang",
                "org": ""
            },
            {
                "name": "Zhengwei Fu",
                "org": ""
            },
            {
                "name": "Weiping Liu",
                "org": ""
            },
            {
                "name": "Jay Gan",
                "org": ""
            }
        ],
        "venue": "Chemical research in toxicology",
        "year": 2009
    },
    "fQYPuUup": {
        "id": "fQYPuUup",
        "title": "Benzotriazole UV 328 and UV-P showed distinct antiandrogenic activity upon human CYP3A4-mediated biotransformation.",
        "abstract": "Benzotriazole ultraviolet stabilizers (BUVSs) are prominent chemicals widely used in industrial and consumer products to protect against ultraviolet radiation. They are becoming contaminants of emerging concern since their residues are frequently detected in multiple environmental matrices and their toxicological implications are increasingly reported. We herein investigated the antiandrogenic activities of eight BUVSs prior to and after human CYP3A4-mediated metabolic activation/deactivation by the two-hybrid recombinant human androgen receptor yeast bioassay and the in\u00a0vitro metabolism assay. More potent antiandrogenic activity was observed for the metabolized UV-328 in comparison with UV-328 at 0.25\u00a0\u03bcM ((40.73\u00a0\u00b1\u00a04.90)% vs. (17.12\u00a0\u00b1\u00a03.00)%), showing a significant metabolic activation. In contrast, the metabolized UV-P at 0.25\u00a0\u03bcM resulted in a decreased antiandrogenic activity rate from (16.08\u00a0\u00b1\u00a00.95)% to (6.91\u00a0\u00b1\u00a02.64)%, indicating a metabolic deactivation. Three mono-hydroxylated (OH) and three di-OH metabolites of UV-328 were identified by ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-Q-TOF-MS/MS), which were not reported previously. We further surmised that the hydroxylation of UV-328 occurs mainly at the alicyclic hydrocarbon atoms based on the in silico prediction of the lowest activation energies of hydrogen abstraction from C-H bond. Our results for the first time relate antiandrogenic activity to human CYP3A4 enzyme-mediated hydroxylated metabolites of BUVSs. The biotransformation through hydroxylation should be fully considered during the health risk assessment of structurally similar analogs of BUVSs and other emerging contaminants.",
        "keywords": [
            "Androgen receptor",
            "Benzotriazole UV stabilizers",
            "Mass spectrometry",
            "Metabolism",
            "Molecular modeling"
        ],
        "authors": [
            {
                "name": "Shulin Zhuang",
                "org": "Institute of Environmental Science, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China; Key Laboratory of Health Risk Factors for Seafood of Zhejiang Province, Zhoushan 316022, China. Electronic address: shulin@zju.edu.cn."
            },
            {
                "name": "Xuan Lv",
                "org": "Institute of Environmental Science, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China; Guangzhou Key Laboratory of Environmental Exposure and Health, School of Environment, Jinan University, Guangzhou 510632, China."
            },
            {
                "name": "Liumeng Pan",
                "org": "Institute of Environmental Science, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Liping Lu",
                "org": "Institute of Environmental Science, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Zhiwei Ge",
                "org": "Institute of Environmental Science, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Jiaying Wang",
                "org": "Institute of Environmental Science, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Jingpeng Wang",
                "org": "Institute of Environmental Science, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Jinsong Liu",
                "org": "Zhejiang Province Environmental Monitoring Center, Hangzhou 310005, China."
            },
            {
                "name": "Weiping Liu",
                "org": "Institute of Environmental Science, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Chunlong Zhang",
                "org": "Department of Biological and Environmental Sciences, University of Houston-Clear Lake, 2700 Bay Area Blvd., Houston, TX 77058, USA. Electronic address: zhang@uhcl.edu."
            }
        ],
        "venue": "Environmental pollution (Barking, Essex : 1987)",
        "year": 2017
    },
    "cF7x1XpJ": {
        "id": "cF7x1XpJ",
        "title": "Visible light-driven iodine-doped titanium dioxide nanotubes prepared by hydrothermal process and post-calcination",
        "abstract": "Iodine-doped TiO 2 nanotubes (I-TNTs) were synthesized, characterized and evaluated in the photocatalytic degradation of phenol. The photocatalytic activity of these new I-TNTs is much greater than that of I-doped TiO 2 nanoparticles, pure TNTs and P25 under visible light irradiation, and the I-TNTs hydrothermally synthesized at 150 \u00b0C are superior to those synthesized at 200 \u00b0C. Abstract A novel class of iodine-doped TiO 2 nanotubes (I-TNTs) has been synthesized via a hydrothermal route using Degussa P25 as a precursor and subsequent calcination. The photocatalytic ability of the products was evaluated in terms of phenol degradation in an aqueous solution under visible light irradiation. The structural properties of the catalysts were characterized by X-ray diffraction (XRD), the Brunauer\u2013Emmett\u2013Teller (BET) method, transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and UV\u2013vis diffuse reflectance spectra. According to the XRD data, I-TNTs are pure anatase, revealing a shift of crystallite phase for P25 from rutile to anatase. The surface area of I-TNTs is significantly larger than that of I-doped TiO 2 (I-TiO 2 ) nanoparticles, which is an important advantage of the photocatalysts formed with a hydrothermal procedure. XPS and UV\u2013vis spectroscopy show that iodine was incorporated into the TiO 2 lattice, and such incorporation extends the photoresponse of TiO 2 from UV to the visible light region. As far as phenol degradation is concerned, the I-TNTs are clearly superior to I-TiO 2 nanoparticles, pure TNTs and P25. The photocatalytic activity of I-TNTs hydrothermally synthesized at 150 \u00b0C had a significantly higher level than that synthesized at 200 \u00b0C. This is attributed to the increase of reactive sites and the enhancement of mass transfer that result from the large surface areas associated with the tubular morphology. Additionally, the increase of Ti 3+ content also contributes to the improvement of photocatalytic activity of I-TNTs. Keywords Titanium dioxide Iodine Nanotube Hydrothermal treatment Photocatalysis 1 Introduction The photocatalytic splitting of water on a titanium dioxide (TiO 2 ) electrode was discovered in 1972 [1] . Since then, TiO 2 has been studied with regard to its potential applications in environmental protection areas, such as air purification, water disinfection, hazardous waste remediation and water purification [2\u20134] , due to its outstanding characteristics, such as chemical stability, non-toxicity, low cost, and high level of efficiency. However, the anatase form of TiO 2 is photocatalytically active under UV light irradiation because of the large intrinsic band gap (\u223c3.2 eV). Thus, if natural sunlight is used for the photoexcitation of titania, only \u223c5% of the incident radiation has sufficient energy for the photocatalytic process. In view of this, there has been a great deal of interest in the preparation of a TiO 2 photocatalyst that is capable of efficient utilization of the visible light that is the main part of the solar spectrum. The wide band gap limitation associated with pure TiO 2 has prompted environmental engineers and scientists to search for innovative solutions. Apart from modification with metal elements [5\u20138] , the doping of non-metal elements, such as nitrogen [9,10] , carbon [11,12] , sulfur [13] , boron [14,15] , phosphorus [16] , and halogen [17\u201319] , into TiO 2 has been regarded as an effective method to increase the photocatalytic activity of TiO 2 in the visible light range because their impurity states are near to the valence band edge, and the doping elements do not act as charge carriers, thus minimizing the combination probability of photoinduced electron\u2013hole pairs [20] . More recently, doping iodine into TiO 2 (I-TiO 2 ) has been the focus of attention [19,21\u201325] . Hong et al. [19] reported for the first time that I-TiO 2 extended its optical absorption into the visible region and considered that it was possible to achieve the substitution of I 5+ for Ti 4+ in a TiO 2 matrix. Subsequently, I-doped mesoporous TiO 2 with a bicrystalline framework was synthesized by a hydrothermal method, and the doped iodine in the titania matrix is completely positive and pentavalent [21] . In contrast, Su et al. [22] used Ti(SO 4 ) 2 and KIO 3 to prepare I-TiO 2 in a hydrothermal procedure and claimed that the iodine exists in both I 7+ and I \u2212 chemical states in I-TiO 2 . In addition, the experimental results reported by Tojo et al. [23] suggested that I 5+ substituted for Ti 4+ and was present in the I\u2013O\u2013Ti bond. Nonetheless, there has been no report of the modification of Degussa P25 with elemental iodine. Degussa P25 is a commercially available titania photocatalyst that has a high level of activity for many kinds of photocatalytic reaction. To date, the preparation of TiO 2 nanotubes (TNTs) from P25 with alkaline solutions has received much attention [26,27] , since they have extraordinarily large surface areas and thereby enhance the mass transfer of reactants. However, the significant limitation of the intrinsic band gap related to TiO 2 has not been improved, i.e. TNTs are generally not sensitive to visible light; therefore, the development of TNTs with an optical absorption edge in the visible light region is a worthwhile subject. Usually, impregnating calcination is employed as a useful technique for modifying TNTs. In this manner, the doping of N, F, and C is done after the preparation of TNTs [28\u201330] . However, to the best of our knowledge, there is no report of doping TNTs with iodine during hydrothermal treatment. The primary objective of this study was to synthesize I-doped TNTs (I-TNTs) via a hydrothermal route combined with iodine doping. After post-heat treatment, the photocatalytic properties were compared with those of I-TiO 2 nanoparticles, TNTs and P25 in the degradation of phenol in aqueous solution. Systematic characterization by methods that include X-ray diffraction (XRD), the Brunauer\u2013Emmett\u2013Teller (BET) measurement, transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and UV\u2013vis diffuse reflectance spectra, was used to elucidate the relationship between the structure and the photoproperties of photocatalysts. 2 Experimental 2.1 Preparation of photocatalysts I-TNTs were prepared by a chemical process similar to that described by Tsai and Teng [31] . In a typical procedure, 4 g of P25 (Degussa) was mixed in 160 mL of aqueous 10 M NaOH containing 6 g of HIO 3 , followed by thermal treatment of the mixture at 150 \u00b0C or 200 \u00b0C in a 200 mL Teflon-lined autoclave for 24 h. The autoclave was allowed to cool to room temperature. The sample was washed thoroughly with 0.1 M HCl and deionized water until the pH of the rinse solution was 7.0. The sample was centrifuged, air-dried at 80 \u00b0C, and finally calcined in a chamber furnace (CWF 1100, CARBOLITE) at 400 \u00b0C with a heating rate of 5 \u00b0C min \u22121 for 2 h. The samples hydrothermally treated at 150 \u00b0C and at 200 \u00b0C are designated I-TNTs-150 and I-TNTs-200, respectively. As a control, TNTs-150 were synthesized using the same procedure without the presence of iodic acid. In addition, the reference I-TiO 2 nanoparticles were prepared as described [19] . Briefly, 50 mL of tetrabutyl titanate was added dropwise into a solution of iodic acid (5.28 g in 200 mL of water) with vigorous stirring. Thereafter, the resultant product was dried at 80 \u00b0C for about 24 h in air followed by calcining at 400 \u00b0C for 2 h. 2.2 Characterization The crystalline phase identification and structural analysis were done by X-ray diffraction (XRD) at room temperature with a Thermo ARL SCINTAG X\u2019TRA diffractometer using Cu K\u03b1 irradiation at 45 kV and a diffracted beam monochromator operated at 40 mA. The surface area of the samples was measured using the BET method by nitrogen adsorption/desorption isotherm measurements at \u2212196 \u00b0C with a Micromeritics ASAP 2010 Analyzer, and the desorption isotherm was used to determine the pore size distribution by the Barrett\u2013Joyner\u2013Halenda (BJH) method. The external features and morphology of the samples were obtained by TEM using a Tecnai G2 F30 S-Twin microscope operated at an accelerating voltage of 300 kV with 0.20 nm point resolution. XPS measurements were done with a PHI 5000C ESCA system with a Mg K\u03b1 source operated at 14.0 kV and 25 mA. All the binding energies were referenced to the C 1s peak at 284.6 eV from the surface adventitious carbon. In addition, UV\u2013vis diffuse reflectance spectra were recorded at room temperature with a Shimadzu UV-2500 UV\u2013vis spectrometer, with BaSO 4 as the background between 240 nm and 800 nm. 2.3 Photocatalytic activity measurements For the photocatalytic experiments, 1.5 g of TiO 2 catalyst was added to 1.5 L of 20 mg L \u22121 aqueous phenol in a water-jacketed cylindrical Pyrex glass reactor (diameter 16 cm; height 20 cm; total capacity 3000 mL) equipped with a 400 W dysprosium lamp (Beijing Electric Light Sources Research Institute, Beijing, China), which has a spectrum very close to that of sunlight, with 1000 mL of 2 M sodium nitrite as a filter for visible light [32] . The suspension was irradiated with stirring, and samples were withdrawn through a port at the top of the reactor. The temperatures of the phenol solution (22 \u00b1 1 \u00b0C) and the filter solution (55 \u00b1 1 \u00b0C) were controlled by a thermostat (THD-2015, Tianheng Instrument Factory, Ningbo, China). Samples of the phenol solution were withdrawn from the reactor at preset time points, centrifuged and passed through a 0.25 \u03bcm pore size membrane to remove any suspended solids. The concentration of phenol was monitored by HPLC (Agilent Technologies, 1200 Series) with an Eclipse XDB-C18 column (150 mm \u00d7 4.6 mm i.d., 5 \u03bcm film thickness). The mobile phase was 50% (v/v) aqueous methanol. The eluent was delivered at a flow rate of 0.8 mL min \u22121 and the absorbance at 269 nm was measured. Finally, the decrease of total organic carbon (TOC), which confirmed the mineralization of phenol, was determined with a TOC-V CPH analyzer (Shimadzu, Kyoto, Japan). 3 Results and discussion 3.1 Crystal structure XRD was used to identify the crystal structure of the TiO 2 samples (TNTs-150, I-TiO 2 , I-TNTs-150, and I-TNTs-200). As shown in Fig. 1 , no peak of crystalline phase relating to iodine was visible, and all samples showed peaks at 2 \u03b8 values of 25.3\u00b0, 37.8\u00b0, 48.0\u00b0, 55.1\u00b0 and 62.7\u00b0, which correspond to anatase (1 0 1), (0 0 4), (2 0 0), (2 1 1) and (2 0 4) crystal planes (JCPDS 21-1272). The diffraction peaks of TNTs-150 and I-TNTs are stronger and narrower than that of I-TiO 2 , implying the enhancement of crystallization of the anatase phase and the growth of crystallites. There is no noticeable difference between the I-TNTs, although the hydrothermal temperature is different. However, as given in Table 1 , the calculated lattice constants a and c deviate slightly from the bulk ( a = 3.781 \u00c5; c = 9.498 \u00c5) values of anatase. This is assumed to be due to the interstitial diffusion of iodine into the TiO 2 lattice, forming I\u2013O\u2013Ti bonds when the I-TNTs were fabricated [23] . Additionally, the starting material, P25 from Degussa, is a mixture of anatase (\u223c83%) and rutile (\u223c17%), while the TNTs are completely anatase. This indicates that the hydrothermal and post-heat treatments can convert the rutile in P25 to anatase via the formation of titanate. It has been confirmed that the TiO 2 nanotubes are derived from layered titanates. For the titanate structures, there should be peaks around 2 \u03b8 values of 10\u00b0, which correspond to the d -spacing of the layered structure [33,34] . To explore whether there remain titanate compounds in the final nanotube products, a small angle XRD test was done. The results in the insets of Fig. 1 show that titanate could not be detected, meaning that titanate is decomposed completely to titania during the sintering. 3.2 BET surface area of samples The surface area ( S BET ), average pore diameter, and pore volume of the samples are summarized in Table 1 . Generally, the surface areas of TNTs are larger than those of I-TiO 2 and P25. In addition, S BET decreases with increasing synthesis temperature (i.e., the hydrothermal treatment temperature) of the I-TNTs. Fig. 2 presents the N 2 adsorption/desorption isotherms and the corresponding pore size distribution curves of TNTs-150, I-TNTs-150, and I-TNTs-200. The isotherm patterns of TNTs are type IV with type H3 hysteresis loops according to the Brunauer\u2013Deming\u2013Deming\u2013Teller (BDDT) classification, which is typical of mesoporous structure. As can be seen from Fig. 2 , the incomplete monolayer adsorption of I-TNTs shifts slightly toward a higher relative pressure value as the hydrothermal temperature goes from 150 \u00b0C to 200 \u00b0C, demonstrating that I-TNTs-150 has slightly smaller pores than I-TNTs-200. The BJH analysis of pore size distribution from the desorption branch of the isotherm reconfirms that the pore size of I-TNTs-150 is larger. Thus, the loss of smaller pores is responsible for the decreased surface area. 3.3 Morphology of samples The hydrothermal temperature has a strong effect on the structure and morphological features of the resulting samples. Fig. 3 shows the TEM images of I-TNTs-150 and I-TNTs-200, and the insets show the corresponding selected area electron diffraction (SAED) pattern and the enlargement of I-TNTs. The SAED patterns indicate that crystallites in the as-prepared samples exist as polycrystallites in the anatase phase. In addition, TEM pictures show that the I-TNTs-150 has predominantly tube-like structures, which are connected randomly in the tube arrangement. Also, I-TNTs-150 displays a clearer and more tube-like morphology than I-TNTs-200. The nanotubes of I-TNTs-150 are two-layer tubes with finite wall thickness, 20\u201380 nm in length, about 7 nm inner diameter and 10 nm outside diameter. Furthermore, the ends are open, which is extremely beneficial for adsorption and photocatalysis. Nanorods are formed when the hydrothermal treatment is done at 200 \u00b0C. Considering the mechanism of rod formation, one would expect the initial nucleation to be accelerated at a high hydrothermal temperature. One suggestion is that the layered structures are very thick due to the rapid growth of particles, resulting in rolling up into nanorods [35] . Another suggestion is that the tube-to-rod structure transformation, involving the oriented attachment of adjacent TNTs together with the local shrinkage of the TNTs by reducing the interlayer distance between the tube walls, occurs at a high hydrothermal temperature [36] . In either case, the nanorods grow at the expense of the internal diameter of nanotubes. The results are consistent with the differences in surface areas obtained by measurement of the nitrogen adsorption/desorption isotherm. 3.4 XPS analysis The chemical state of any doping impurity is critical to the optical property, band-gap and the photocatalytic activity of doped TiO 2 . The XPS spectra ( Fig. 4 ) for I-TiO 2 and I-TNTs show peaks of binding energy (BE) for Ti 2p, I 3d, O 1s, and C 1s. To investigate the chemical states of titanium and iodine, we analyzed the high-resolution XPS spectra of Ti 2p and I 3d; results are shown in the insets in Fig. 4 . The Ti 2p peak is well fit into the peaks of Ti 3+ (\u223c457.4 eV) and Ti 4+ (\u223c458.5 eV). Ti 3+ on the TiO 2 surface can be created by a variety of methods, such as UV radiation, annealing in vacuo , ion sputtering, plasma treatment, and ion doping [37\u201340] . The existence of surface states of Ti 3+ can hinder the recombination of electron\u2013hole pairs [21] , which may be one of the reasons for the improved photocatalytic activity. The molar ratios of trivalent titanium to the sum of trivalent and tetravalent titanium, abbreviated here as Ti 3+ /(Ti 3+ + Ti 4+ ), for I-TiO 2 and for I-TNTs-150 show a faint distinction in Table 1 , while the ratio of I-TNTs-150 is approximately 18% higher than that of I-TNTs-200. The assignment of the XPS peak of I 3d is under dispute. The peak of I 3d 5/2 at about 627.5 eV was previously attributed to substitutional I 5+ [19] . Recently, the feature seemed to be completely absent when the I-TiO 2 was prepared via a hydrothermal process. Instead, the peaks of I 3d 5/2 were situated in the region 623.6\u2013624.5 eV, and the BEs were higher than that of HIO 3 (623 eV) [21\u201323] . After calculating the data reported here, we found that the BE of I 3d 5/2 for I 7+ and I 3d 5/2 for I 5+ is \u223c5 eV and \u223c3.5 eV higher than the I 3d 3/2 for I \u2212 , respectively. Fig. 4 explores the spectra in the core level for I 3d of our samples and the corresponding fitted curves. Each sample has two peaks: for I-TiO 2 , the peaks are observed at the BEs of 620.2 eV (I 3d 3/2 ) and 623.8 eV (I 3d 5/2 ). For I-TNTs, the peaks of I-TNTs-150 are located at 620.2 eV (I 3d 3/2 ) and 624 eV (I 3d 5/2 ), and the peaks of I-TNTs-200 are located at 620.4 eV (I 3d 3/2 ) and 624 eV (I 3d 5/2 ). Then, the difference values between I 3d 5/2 and I 3d 3/2 are 3.6 eV, 3.8 eV and 3.6 eV for I-TiO 2 , I-TNTs-150 and I-TNTs-200, respectively. Thus, it is more likely that the first peak of our sample is I \u2212 species and the second is I 5+ . 3.5 UV\u2013vis absorption spectroscopy To study the optical response of doped TiO 2 powders, we measured the UV\u2013vis absorption spectra of I-TiO 2 , TNTs-150, I-TNTs-150, and I-TNTs-200, results are shown in Fig. 5 . The absorption thresholds for TNTs-150, I-TiO 2 , I-TNTs-150, and I-TNTs-200 are estimated to be \u223c390 nm, \u223c433 nm, \u223c406 nm, and \u223c407 nm, respectively, which is in accordance with the yellow color of the I-doped samples. The optical absorption edge of the samples shows an appreciable shift to the visible light region after iodine doping. The band gaps of the samples can be calculated from the intercept of UV\u2013vis spectra using the following equation: E g = 1240 \u03bb and the results are given in Table 1 . 3.6 Photocatalytic activities Phenol, which has no absorption in the visible region and typically occurs in phenolic compounds, is commonly found in industrial wastewater. Consequently, phenol is chosen as a model target pollutant to assess the photocatalytic activity of TiO 2 samples under visible light irradiation. Fig. 6 a illustrates the degradation of phenol in the presence of TNTs-150, P25, I-TiO 2 , I-TNTs-150, I-TNTs-200, and in the absence of catalysts under visible light irradiation, as well as the absorption of phenol on I-TNTs-150 in darkness. No obvious change of the concentration of phenol could be observed with I-TNTs-150 in darkness or without catalysts under visible light irradiation. I-TiO 2 , I-TNTs-150, and I-TNTs-200 all reveal a higher degree of photocatalytic activity than P25 and TNTs-150. Moreover, the destruction of organic pollutants should be regarded as an overall degradation process that ultimately involves mineralization of both the parent substance and its intermediates, and the TOC of the aqueous phenol solution via photocatalytic processes is detected to evaluate its degree of mineralization. The efficiency of photomineralization of phenol is shown in Fig. 6 b. There is a clear decrease of 85% for TOC of phenol after 4 h using I-TNTs-150 as the photocatalyst under visible light irradiation, which is notably higher than the values for TNTs-150, P25, I-TiO 2 or I-TNTs-200. It should be noted that the surface area of TNTs-150 is 252 m 2 g \u22121 whereas for I-TiO 2 the surface area is 127 m 2 g \u22121 . Although the surface area of TNTs-150 is about two times that of I-TiO 2 ; the degradation of phenol is greater using I-TiO 2 . The efficient photoresponse in the visible light region for I-TiO 2 , I-TNTs-150, and I-TNTs-200 is attributed to iodine doping. The action of iodine reduces the band gap energy by forming doping levels in the band gap of TiO 2 . Additionally, the doping iodine sites could act as trapping sites to capture the photoinduced electron, thereby efficiently inhibiting the recombination of the photogenerated electron\u2013hole pairs [23,41] . As far as the iodine-doped samples are concerned, the photocatalytic activity of I-TNTs is much greater than that of I-TiO 2 , and I-TNTs-150 is superior to I-TNTs-200, achieving a nearly complete removal of phenol after 4 h, as will be discussed below. The crystallinity, surface area, and morphology can greatly influence the photocatalytic activity of titania [21] , which is widely believed to be phase-dependent. However, the phase influence should be neglected in our experiments, because I-TiO 2 , and I-TNTs are both in the anatase phase, and so the variation in photocatalytic activity cannot originate from the difference of crystal phase. The TEM images indicate that the tubular structure is connected randomly, which promotes the diffusion of reactants and products, enhancing the photocatalytic activity by facilitating access to the reactive sites on the surface of the photocatalyst [21] . In addition, photocatalytic reactions are believed to take place on the illuminated surface. The tube-like structure increases the surface areas significantly and, consequently, helps rapid mass transfer of the adsorbed molecules from bulk solution onto the catalyst surface, causing the photocatalytic process to be accelerated [42] . Therefore, the greater surface area of I-TNTs favors intimate contact with higher visible light-induced photocatalytic activity. The molar ratios of iodine to titanium (I/Ti) should be a vital parameter that affects the photodegradation of phenol in the system. As shown in Table 1 , no obvious difference of I/Ti is found, although the rates of degradation of phenol are remarkably different, implying that the effect of iodine content should be discounted in these experiments. However, after reaction for 4 h, the efficiency of phenol removal by I-TNTs-150 is 11% higher than that by I-TNTs-200, correspondingly, 85% of the TOC is mineralized in the presence of I-TNTs-150, whereas only 74% TOC is transformed into CO 2 with I-TNTs-200. By careful analysis of the data in Table 1 , we ascertain that the higher Ti 3+ content should be responsible for the influence of the photocatalytic activity in this case, since the surface areas of the two I-TNTs are similar. 4 Conclusions In summary, we have developed a hydrothermal method for the preparation of I-TNTs with an anatase framework. I 5+ substituted for Ti 4+ in a titania matrix is proved to be an important factor in extending the photocatalytic activity in the visible light range. I-TNTs markedly improve the visible light photocatalytic capabilities of phenol degradation, and the highest level of photoactivity was observed for the sample obtained by hydrothermal treatment at 150 \u00b0C and calcinated at 400 \u00b0C. This is because the I-TNTs-150 has the highest Ti 3+ content, inhibiting the recombination of photogenerated electron and hole. It also has the greatest surface area with a tubular structure. Such a structure affords more reactive sites and improves the mass transfer of organic reactants from bulk solution to the surface of catalysts. The materials described here may be helpful in new efforts for the preparation and characterization of excellent visible light response TiO 2 photocatalysts. Acknowledgements This work was supported by the National Basic Research Program of China (Grant No. 2009CB421603 ), National Natural Science Foundation of China (No. 20977086 ) and Zhejiang Provincial Natural Science Foundation of China (Grant No. Z5080207 ). The authors are grateful to Dr. Anyuan Yin from Fudan University for his kind help with the XPS measurements. References [1] A. Fujishima K. Honda Nature 238 1972 37 38 [2] M.R. Hoffmann S.T. Martin W.Y. Choi D.W. Bahnemann Chem. Rev. 95 1995 69 96 [3] J.C. Yu J.G. Yu J.C. Zhao Appl. Catal. B: Environ. 36 2002 31 43 [4] P. Pizarro C. Guillard N. Perol J.M. Herrmann Catal. Today 101 2005 211 218 [5] K. Dai T.Y. Peng H. Chen J. Liu L. Zan Environ. Sci. Technol. 43 2009 1540 1545 [6] J.A. Nav\u00edo G. Col\u00f3n M. Mac\u00edas C. Real M.I. Litter Appl. Catal. A: Gen. 177 1999 111 120 [7] H. Kisch L. Zang C. Lange W.F. Maier C. Antonnius D. Meissner Angew. Chem. Int. Ed. 37 1998 3034 3036 [8] M. Anpo M. Takeuchi J. 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        "keywords": [
            "hydrothermal treatment",
            "iodine",
            "nanotube",
            "photocatalysis",
            "titanium dioxide",
            "diffuse reflectance",
            "mass transfer",
            "x ray diffraction",
            "uv vis spectroscopy",
            "visible light",
            "surface area",
            "transmission electron microscopy",
            "x ray photoelectron spectroscopy",
            "aqueous solution"
        ],
        "authors": [
            {
                "name": "Shuang Song",
                "org": ""
            },
            {
                "name": "Jinjun Tu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, People's Republic of China"
            },
            {
                "name": "Zhiqiao He",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, People's Republic of China"
            },
            {
                "name": "Fangyue Hong",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, People's Republic of China"
            },
            {
                "name": "Weiping Liu",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, People's Republic of China"
            },
            {
                "name": "Jianmeng Chen",
                "org": "College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, People's Republic of China"
            }
        ],
        "venue": "Applied Catalysis A, General",
        "year": 2010
    },
    "TpLlZjws": {
        "id": "TpLlZjws",
        "title": "Enrichment of steroid hormones in water with porous and hydrophobic polymer-based SPE followed by HPLC-UV determination: Liquid Chromatography",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yinfen hu",
                "org": ""
            },
            {
                "name": "man zhang",
                "org": ""
            },
            {
                "name": "changlun tong",
                "org": ""
            },
            {
                "name": "jianmin wu",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            }
        ],
        "venue": "Journal of Separation Science",
        "year": 2013
    },
    "cyrSdvDa": {
        "id": "cyrSdvDa",
        "title": "The molecular mechanism of the antagonistic activity of hydroxylated polybrominated biphenyl (OH-BB80) toward thyroid receptor \u03b2.",
        "abstract": "Polybrominated biphenyls (PBBs) were widely used as additive brominated flame retardants. Their hydroxylated products (OH-PBBs) have been detected frequently in various marine mammals, causing an increased health risk. Till now, there lacks information on the potential disruption of OH-PBBs toward thyroid hormone receptor (TR) and the molecular characteristics of their interactions remain largely unknown. We herein in vitro and in silico evaluated the disrupting effect of 3,3',5,5'-tetrabromobiphenyl (BB80) and its metabolite 2,2'-dihydroxy- 3,3',5,5'-tetrabromobiphenyl (OH-BB80) toward human TR. The recombinant human TR\u03b2 two-hybrid yeast assay reveals the moderate antagonistic activity of OH-BB80 with IC at 2\u202f\u03bcmol/L, while BB80 shows no agonistic or antagonistic activity. OH-BB80 binds at the binding cavity of TR\u03b2 ligand binding domain (LBD) and forms one hydrogen bond with Phe272. Electrostatic interactions and hydrophobic interactions contribute much to their interactions. The binding of OH-BB80 quenches the intrinsic fluorescence of TR\u03b2 LBD at static quenching mode. Our study extends knowledge on the endocrine disrupting effect of OH-PBBs and suggests the full consideration of the biotransformation for further health risk assessment of PBBs and related structurally similar emerging contaminants.",
        "keywords": [
            "Endocrine disrupting effect",
            "Hydroxylated brominated biphenyls",
            "Metabolic activation",
            "Molecular interactions"
        ],
        "authors": [
            {
                "name": "Xiaofang Zhang",
                "org": "College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Shixuan Cui",
                "org": "College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Liumeng Pan",
                "org": "Hubei Province Environmental Monitoring Center, Wuhan 430072, China."
            },
            {
                "name": "Wenhua Dong",
                "org": "College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Mei Ma",
                "org": "Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100085, China."
            },
            {
                "name": "Weiping Liu",
                "org": "College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China."
            },
            {
                "name": "Shulin Zhuang",
                "org": "College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: shulin@zju.edu.cn."
            }
        ],
        "venue": "The Science of the total environment",
        "year": 2019
    },
    "eKHCeVhB": {
        "id": "eKHCeVhB",
        "title": "Cleaner and convenient preparation of 3-(4,6-dimethoxy-pyrimidin-2-yloxy)-2-methyl-phenol.",
        "abstract": "Environmental concerns have highlighted the need of cleaner technologies. A cleaner, convenient and selective technology has been developed for the preparation of 3-(4,6-dimethoxy-pyrimidin-2-yloxy)-2-methyl-phenol (DPMP) from 2-methyl-benzene-1,3-diol in water as solvent. The isolated yield of DPMP is up to 86% in good selectivity. The product structure was characterized by conventional methods, 1H-NMR and MS. This technology belongs to the modern concept of environmentally friendly low wastes or non-wastes technology (LWNWT).",
        "keywords": [
            "Cleaner preparation",
            " Greener technology",
            " Selective synthesis",
            " 2-methyl-benzene-1",
            " 3-diol",
            " 3-(4",
            "6-dimethoxy-pyrimidin-2-yloxy)-2-methyl-phenol",
            " A",
            " X383"
        ],
        "authors": [
            {
                "name": "Yue-Zhong Wen",
                "org": "Institute of Environmental Science, College of Environmental & Resource Sciences,Zhejiang University,Hangzhou,China"
            },
            {
                "name": "Zhao-Hua Fang",
                "org": "Institute of Environmental Science, College of Environmental & Resource Sciences,Zhejiang University,Hangzhou,China"
            },
            {
                "name": "Wei-Ping Liu",
                "org": "Institute of Environmental Science, College of Environmental & Resource Sciences,Zhejiang University,Hangzhou,China"
            }
        ],
        "venue": "Journal of Zhejiang University. Science",
        "year": 2004
    },
    "dkTEZ2gG": {
        "id": "dkTEZ2gG",
        "title": "Development of chiral stationary phases for high-performance liquid chromatographic separation",
        "abstract": "",
        "keywords": [
            "rational design",
            "biochemical",
            "resolution",
            "chromatography",
            "computational chemistry"
        ],
        "authors": [
            {
                "name": "mengling tang",
                "org": ""
            },
            {
                "name": "jing zhang",
                "org": ""
            },
            {
                "name": "shulin zhuang",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            }
        ],
        "venue": "Trends in Analytical Chemistry",
        "year": 2012
    },
    "BQUXLtYu": {
        "id": "BQUXLtYu",
        "title": "Potential Estrogenic Effects of Phosphorus-Containing Flame Retardants",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xiaowu dong",
                "org": ""
            },
            {
                "name": "quan zhang",
                "org": ""
            },
            {
                "name": "meiya lu",
                "org": ""
            },
            {
                "name": "chunlong zhang",
                "org": ""
            },
            {
                "name": "meirong zhao",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "cui wang",
                "org": ""
            }
        ],
        "venue": "Environmental Science & Technology",
        "year": 2014
    },
    "dUofZbzQ": {
        "id": "dUofZbzQ",
        "title": "Congener-specific C 10 C 13 and C 14 C 17 chlorinated paraffins in Chinese agricultural soils: Spatio-vertical distribution, homologue pattern and environmental behavior.",
        "abstract": "A comprehensive spatio-vertical survey of short-chain (SCCPs, C) and medium-chain (MCCPs, C) chlorinated paraffins (CPs) was performed in surface and core soils from Chinese nation-wide agricultural lands in 2016, and a total of 48 congener groups were measured. The shorter carbon chain C in SCCP and C in MCCP homologue groups, and the lower chlorinated congeners (Cl) for both CP groups were predominant. The \u2211SCCP and \u2211MCCP concentrations in surface soils ranged from 39 to 1609\u202fng/g and 127-1969\u202fng/g, dry weight (dw), respectively. The spatial distribution trend showed that SCCP congener groups with relatively low octanol-water partition coefficient (K) and octanol-air partition coefficient (K) are uniformly distributed across surface soils compared to MCCP congener groups. Significant relationships were observed between the spatial variation of SCCP concentrations and the driving factors responsible for dispersion and deposition. The distribution behavior of SCCPs and MCCPs in highland and plain surface soils showed an increasing trend of MCCP concentrations with elevation, indicating the \"mountain cold-trapping effect\". Vertical distribution profile revealed similar homologue group composition patterns of SCCP and MCCP congener groups as those of surface soils. Furthermore, the penetration potential ratios (r) of chlorine and carbon atoms of CPs demonstrated that the lower chlorinated (Cl) and the shorter carbon chain (C) congener groups are more prone to vertical movement into deeper soil layers compared to the longer carbon chain (C) and highly chlorinated (Cl) congener groups.",
        "keywords": [
            "Agricultural soil",
            "Chlorinated paraffins",
            "Environmental behavior",
            "Homologue pattern",
            "Spatio-vertical distribution"
        ],
        "authors": [
            {
                "name": "Muhammad Aamir",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, Institute of Environmental Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China."
            },
            {
                "name": "Shanshan Yin",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, Institute of Environmental Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China."
            },
            {
                "name": "Yuting Zhou",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, Institute of Environmental Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China."
            },
            {
                "name": "Chenye Xu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, Institute of Environmental Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China."
            },
            {
                "name": "Kai Liu",
                "org": "Department of Environmental Science and Engineering, W. M. Keck Laboratories, California Institute of Technology, 1200 East California Blvd, Pasadena, CA, 91125, USA."
            },
            {
                "name": "Weiping Liu",
                "org": "MOE Key Laboratory of Environmental Remediation and Ecosystem Health, Institute of Environmental Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China. Electronic address: wliu@zju.edu.cn."
            }
        ],
        "venue": "Environmental pollution (Barking, Essex : 1987)",
        "year": 2018
    },
    "EYdIKZRJ": {
        "id": "EYdIKZRJ",
        "title": "Study on Immunotoxicity of Pesticides",
        "abstract": "The increase of diseases can be attributable to the turbulence of the immune system function, and this trend could be at least partially bottom of new and modified patterns of exposure to chemicals in environment. Among chemicals of concern, pesticides can be included. The present review describes the definition of immunotoxicity, the immunotoxicity test methods, the relation of pesticide and immune response and the immunotoxicity of pesticides in aquatic species, terrestrial species, mammals and human. The importance of studying the immunotoxicity of chiral pesticides is also introduced and prospected.",
        "keywords": [
            "pesticide",
            "immune response",
            "immunotoxicity"
        ],
        "authors": [
            {
                "name": "LU Xian-ting",
                "org": " Research Center of Environmental Science, Zhejiang University of Technology, Hangzhou ; Institute of Environmental Science and Engineering, Hangzhou Dianzi University, Hangzhou "
            },
            {
                "name": "ZHAO Mei-rong",
                "org": " Research Center of Environmental Science, Zhejiang University of Technology, Hangzhou "
            },
            {
                "name": "LIU Wei-ping",
                "org": " Research Center of Environmental Science, Zhejiang University of Technology, Hangzhou "
            }
        ],
        "venue": "Asian Journal of Ecotoxicology",
        "year": 2007
    },
    "38jL9Ztq": {
        "id": "38jL9Ztq",
        "title": "Determination of Metalaxyl Enantiomeric Purity by Nonchiral High Performance Liquid Chromatography with Circular Dichroism Detector",
        "abstract": "A novel method for the determination of enantiomeric purity of chiral compounds by nonchiral high performance liquid chromatography(HPLC) coupled with circular dichroism(CD) detector was developed.The principle of the method was proposed and illustrated by the analysis of enantiomeric purity of metalaxyl.The results indicated that g values(anisotropy factor) had a good linearity with enantiomeric excess(ee) and correlation coefficient was 0.9974.The relative average deviations between the ee evaluated by the developed method and those determined by chiral HPLC were less than 3.0%.The proposed method has a high accuracy and shows a good perspective to determine the ee of chiral compounds.",
        "keywords": [
            "metalaxyl",
            "Circular dichroism",
            "anisotropy(factor)",
            "enantiomericpurity",
            "high performance liquid chromatography"
        ],
        "authors": [
            {
                "name": "Chen Shengwen",
                "org": "Institute of Environmental Science,Zhejiang University,Hangzhou "
            },
            {
                "name": "Lin Kunde",
                "org": "Institute of Environmental Science,Zhejiang University,Hangzhou "
            },
            {
                "name": "Xi Meng",
                "org": "Institute of Environmental Science,Zhejiang University,Hangzhou "
            },
            {
                "name": "Liu Weiping",
                "org": ""
            }
        ],
        "venue": "Chinese Journal of Analytical Chemistry",
        "year": 2006
    },
    "UNNE70GH": {
        "id": "UNNE70GH",
        "title": "Application of Image Processing Technology of HREM Images",
        "abstract": "Detailed classification of image processing technology of high-resolution electron microscopy(HREM) is done.The necessity of HREM combining image processing technology in determining the crystal structure is analyzed.The three image processing technologies are discussed.Some successful applications of these technologies in materials science are introduced.The application range,foreground and limit of image processing technology are described lastly.",
        "keywords": [
            "image processing",
            "HREM",
            "crystal structure"
        ],
        "authors": [
            {
                "name": "WANG Xinxing",
                "org": " Faculty of Materials Science and Chemical Engineering,China University of Geosciences,Wuhan ; Graduate School,China University of Geosciences,Wuhan "
            },
            {
                "name": "WU Xiuling",
                "org": " Faculty of Materials Science and Chemical Engineering,China University of Geosciences,Wuhan "
            },
            {
                "name": "LIU Weiping",
                "org": " Faculty of Materials Science and Chemical Engineering,China University of Geosciences,Wuhan ; Graduate School,China University of Geosciences,Wuhan "
            },
            {
                "name": "SUN Junying",
                "org": " Faculty of Materials Science and Chemical Engineering,China University of Geosciences,Wuhan ; Graduate School,China University of Geosciences,Wuhan "
            }
        ],
        "venue": "Materials Review",
        "year": 2007
    },
    "39Y9H4mk": {
        "id": "39Y9H4mk",
        "title": "Microstructure Defects in Ultrahigh-pressure Metamorphic Rock: Evidence from TEM and FTIR Studies",
        "abstract": "Defect microstructures of minerals are a potential indicator of extremely rapid and episodic exhumation of ultrahigh-pressure (UHP) metamorphic rock. The microstructure defects in the minerals from UHP jadeite quartzite at Shuanghe, Dabie Mountains, China, have been investigated using transmission electron microscope (TEM) and Fourier transform infrared spectroscopy (FTIR). TEM observations indicate that three polymorphs, namely, submicron-scale nature monalbite (MA, C 2/ m ) (about 0.8 \u03bcm), high albite (HA, C \u012a), and low albite (LA, C \u012a) occur in jadeite inclusions from jadeite quartzite. The existence of monalbite (MA) implies that high-temperature metamorphism (>930 \u00b0C) takes place during exhumation and rapid cooling, during retrogression. The occurrence of nanoscale coesite (about 80 nm) and halite daughter minerals in quartz inclusions provide evidence for the transformation of the original coesite to quartz and the existence of high-salty fluids at peak metamorphic conditions. Structural water (OH/H 2 O) in nominally anhydrous minerals (NAMs) exists in the structures of these minerals as defects. The FTIR results show that the average contents of structural water in jadeite, garnet, rutile, and quartz are 1000 \u00d7 10 \u22126 , (900\u20131600) \u00d7 10 \u22126 , > 2000 \u00d7 10 \u22126 , and < 4 \u00d7 10 \u22126 , respectively, and the estimated whole-rock water content is (490\u2013600) \u00d7 10 \u22126 . The results reveal that the water in crust or protolith can transport into the earth's depth through NAMs during HP-UHP metamorphism. These unique defect microstructures can be rationalized by a high strain rate at local weakening and deep faulting of continental collision orogens.",
        "keywords": [
            "mineral inclusions",
            "tem",
            "uhp jadeite-quartzite",
            "defect microstructures",
            "dabie mountains",
            "china",
            "microstructures",
            "fourier transform infrared spectroscopy",
            "water content",
            "polymorphism",
            "transmission electron microscope"
        ],
        "authors": [
            {
                "name": "Xiuling WU",
                "org": "Faculty of Materials Science and Chemical Engineering, China University of Geosciences, Wuhan 430074, China"
            },
            {
                "name": "Dawei MENG",
                "org": "Faculty of Materials Science and Chemical Engineering, China University of Geosciences%%#Wuhan%%#, Wuhan , China"
            },
            {
                "name": "Zhengjie ZHANG",
                "org": "Faculty of Materials Science and Chemical Engineering, China University of Geosciences, Wuhan 430074, China"
            },
            {
                "name": "Xiaoyu FAN",
                "org": "Faculty of Materials Science and Chemical Engineering, China University of Geosciences, Wuhan 430074, China"
            },
            {
                "name": "Liwu HUANG",
                "org": "Faculty of Materials Science and Chemical Engineering, China University of Geosciences, Wuhan 430074, China"
            },
            {
                "name": "Weiping LIU",
                "org": "Faculty of Materials Science and Chemical Engineering, China University of Geosciences, Wuhan 430074, China"
            },
            {
                "name": "Jianping ZHENG",
                "org": "Faculty of Earth Sciences, State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan 430074, China"
            }
        ],
        "venue": "Earth Science Frontiers",
        "year": 2008
    },
    "OVUAGYrb": {
        "id": "OVUAGYrb",
        "title": "First-principles calculations of the electronic structure of \u03b1-PbO2-type TiO2",
        "abstract": "On the basis of first-principle calculations, the cell parameters and electronic structure of \u03b1-PbO2-type TiO2 were calculated by using the plane-wave ultra-soft pseudo-potential method in line with the density functional theory (DFT) and with the generalized gradient approximation (GGA). The optimized cell parameters were in good agreement with related experimental data. Electronic structure analysis revealed that \u03b1-PbO2-type TiO2 was an indirect wide-band semiconductor with a band gap of 2.47 eV, lager than the anatase TiO2 band gap, which may be caused by lower crystal symmetry, the average longer Ti-O band length and the weaker extent of mixing of the Ti3d and O2p orbits of high-pressure orthorhombic \u03b1-PbO2-type TiO2. It was theoretically suggested that photocatalytic effect of \u03b1-PbO2-type TiO2 was not as good as that of anatase TiO2.",
        "keywords": [
            "\u03b1-PbO2-type TiO2",
            "Electronic structure",
            "First principles",
            "High-pressure phase"
        ],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Xiuling Wu",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Dawei Meng",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Meihua Yu",
                "org": "Guangxi University(Guangxi University),Nanning,China"
            },
            {
                "name": "Hong Chen",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "ZhengJie Zhang",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Jianping Zheng",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            }
        ],
        "venue": "Kuangwu Yanshi/ Journal of Mineralogy and Petrology",
        "year": 2008
    },
    "lHNOoV58": {
        "id": "lHNOoV58",
        "title": "Compressibility and Structural Properties of Jadeite, NaAlSi_2O_6 at High Pressure",
        "abstract": "The structural properties of jadeite at high pressures (0.000 1-30 GPa) are investigated using plane-wave pseudopotential density functional theory method. As a function of pressure, the monoclinic cell parameters were calculated and the compressibility coefficients are 0.002 6, 0.002 3 and 0.002 6 GPa-1, respectively. The bond length, bond angle and distortion variation were studied in order to obtain the information of polyhedral compression. The pressure-volume equation of state was considered in order to obtain the bulk modulus K0. Comparison between the calculated K0 values and the experimental data suggested that the model provides reasonable insights into crystallographic and physical properties of jadeite.",
        "keywords": [
            "bulk modulus.",
            "jadeite",
            "first-principles calculation",
            "compression",
            "structural parameter",
            "polyhedron"
        ],
        "authors": [
            {
                "name": "Xiuling Wu",
                "org": " State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan , China"
            },
            {
                "name": "Xiaoyu Fan",
                "org": " State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan , China"
            },
            {
                "name": "Fei Qin",
                "org": " State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan , China"
            },
            {
                "name": "Dawei Meng",
                "org": " State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan , China"
            },
            {
                "name": "Xiaoling Zhang",
                "org": " State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan , China"
            },
            {
                "name": "Long Chen",
                "org": " State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan , China"
            },
            {
                "name": "Weiping Liu",
                "org": " State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan , China"
            },
            {
                "name": "Jianping Zheng",
                "org": " State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan , China"
            }
        ],
        "venue": "\u5730\u7403\u79d1\u5b66\u5b66\u520a(\u82f1\u6587\u7248)",
        "year": 2013
    },
    "un4rauio": {
        "id": "un4rauio",
        "title": "The electronic structure and infrared spectroscopy of Al-H and Fe-H codoped rutile-type TiO2",
        "abstract": "Rutile from Shuanghe and Bixiling area in the Dabie Orogen were investigated by Micro- Fourier transform infrared spectroscopy (FTIR). The results show that all the grains exhibit a sharp band near 3280 cm-1 or 3295 cm-1. Two structures have been suggested about the position of H in rutile, namely the chanel center (CC) and basal octahedron edge (BOE) models. The lattice structure and electronic band structure of Al-H and Fe-H codoped rutile TiO2 has been calculated by first-principles method. According to O-H bond vibration frequency of FTIR and O-H\u22efO bond distance between O-O of computational results, we deduce that modified channel center (MCC) model is more reasonable. The calculation results indicate that the t2g state of Fe overlaps with the O 2p state, which will narrow the band gap and lead to red shift in optical absorption spectra. \u00a9 2011 Chinese Physical Society.",
        "keywords": [
            "Channel center",
            "Electronic structure",
            "First-principles",
            "Rutile-type TiO2"
        ],
        "authors": [
            {
                "name": "ZhengJie Zhang",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Dawei Meng",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Xiuling Wu",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "KaiHua He",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Xiaoyu Fan",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "LiWu Huang",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Jianping Zheng",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            }
        ],
        "venue": "Wuli Xuebao/Acta Physica Sinica",
        "year": 2011
    },
    "abrvi3jF": {
        "id": "abrvi3jF",
        "title": "The Influence of Doping Rare Earth Elements on Nano-sized TiO_2 and Doping Mechanism",
        "abstract": "The effect of doping rare earth elements on phase-transformation temperature,crystal size and spectral response range of nano-TiO_2 are summarized in this paper.The investigation progresses in the doping mecha- nism and the photocatalysis influencing factors of the same rare earth element doped TiO_2 are introduced in detail.The problems at present and research directions of rare-earth elements doped nano-TiO_2 in the future are also put forward.",
        "keywords": [
            "rare earth elements",
            "nano-TiO_2",
            "doping mechanism"
        ],
        "authors": [
            {
                "name": "SUN Junying",
                "org": " Faculty of Materials Science and Chemical Engineering,China University of Geoseiences,Wuhan ; Graduate School,China University of Geosciences,Wuhan "
            },
            {
                "name": "MENG Dawei",
                "org": " Faculty of Materials Science and Chemical Engineering,China University of Geoseiences,Wuhan "
            },
            {
                "name": "WANG Xinxing",
                "org": " Faculty of Materials Science and Chemical Engineering,China University of Geoseiences,Wuhan ; Graduate School,China University of Geosciences,Wuhan "
            },
            {
                "name": "LIU Weiping",
                "org": " Faculty of Materials Science and Chemical Engineering,China University of Geoseiences,Wuhan ; Graduate School,China University of Geosciences,Wuhan "
            },
            {
                "name": "WANG Ge",
                "org": " Liaoyuan College of Vocation Technique,Liaoyuan "
            }
        ],
        "venue": "Materials Review",
        "year": 2007
    },
    "JtAkLHXr": {
        "id": "JtAkLHXr",
        "title": "Water in UHP jadeite quartzites of Dabie mountains: Evidence from micro FTIR",
        "abstract": "The distribution characteristics of structural water in nominally anhydrous minerals (NAMs) from Dabie mountains can provide important microscopic information on some aspects of the related fluid activities, mineral deformation, dynamical process of blocks subduction and exhumation. The NAMs such as jadeites, garnets, rutiles and quarts in ultra-high pressure (UHP) jadeite quartzites of Shuanghe and Bixiling areas from Dabie mountains were investigated by Fourier transform infrared spectroscopy (FTIR), the result of which indicates that NAMs contain hydrogen occurring as hydroxyl (OH-) or molecule H2O. It is found that the average structural water contents of the jadeites from the two areas are both close to 1000 \u00d7 10-6; the rutilezs are both above 2000 \u00d7 10-6; the quarts are both <4 \u00d7 10-6. The structural water contents of garnets from different grains in the same area arent uniform, while the water contents of UHP jadeite quartzites from the two areas both range from 900 \u00d7 10-6 to 1600 \u00d7 10-6.The results reveal that the water in crust or protolith can be transported into the earths depth through NAMs in the UHP metamorphic rocks during the formation of the HP UHP metamorphic rocks.",
        "keywords": [
            "Dabie mountains",
            "Infrared spectroscopy",
            "NAMs",
            "The structural water",
            "Ultra-high pressure jadeite quartzites"
        ],
        "authors": [
            {
                "name": "Xiaoyu Fan",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Xiuling Wu",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Dawei Meng",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Xinxing Wang",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Jianping Zheng",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            }
        ],
        "venue": "Diqiu Kexue - Zhongguo Dizhi Daxue Xuebao/Earth Science - Journal of China University of Geosciences",
        "year": 2007
    },
    "In1YcnOi": {
        "id": "In1YcnOi",
        "title": "Structural water in ultra-high pressure eclogites at Shima and Yingshan, Dabie Mountains: FTIR analysis",
        "abstract": "The nominally anhydrous minerals (NAMs) such as garnets and omphacites in ultra-high pressure eclogites of Shima and Yingshan areas from Dabie Mountains were investigated by Fourier transform infrared spectroscopy, which indicates that NAMs could contain hydrogen occurring as hydroxyl (OH) or molecule H 2O. It was found that the water contents aren't uniform in NAMs from different areas to the same area, and from the different grains at the same area to the different position in the same grain. The structural water contents of the omphacites at Shima and Yingshan are respectively from (90-1670) \u00d710 -6 and from (110-710)\u00d710 -6; while the garnets' are from (510-830)\u00d710 -6 and (0-180)\u00d710 -6. Former academicians initially discuss the influence of structural water on the eclogites' deformation and the relationship between structural water and fluid inclusions in NAMs combining with the related work. \u00a9 2007 Taylor & Francis Group, London.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Xiaoyu Fan",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Xiuling Wu",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Dawei Meng",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "LiWu Huang",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Fan Sun",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Shumin Cao",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Weiping Liu",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            },
            {
                "name": "Jianping Zheng",
                "org": "China University of Geosciences(China University of Geosciences),Wuhan,China"
            }
        ],
        "venue": "Water-Rock Interaction - Proceedings of the 12th International Symposium on Water-Rock Interaction, WRI-12",
        "year": 2007
    },
    "IFwf0GjO": {
        "id": "IFwf0GjO",
        "title": "Manganese(I)-Catalyzed Dispersion-Enabled C-H/C-C Activation.",
        "abstract": "C-H/C-C Functionalizations were achieved with the aid of a versatile manganese(I) catalyst. Thus, an organometallic manganese-catalyzed C-H activation set the stage for silver-free C-H/C-C transformations with ample substrate scope and excellent levels of chemo-, site-, and diastereo-selectivities. The robust nature of the manganese(I) catalysis regime was reflected by the first C-H/C-C functionalization on amino acids under racemization-free reaction conditions. Detailed experimental and computational mechanistic studies provided strong evidence for a facile C-H activation and a rate-determining C-C cleavage, with considerable contribution from London dispersion interactions.",
        "keywords": [
            "C\u2212C cleavage",
            "C\u2212H activation",
            "amino acids",
            "heteroarenes",
            "manganese"
        ],
        "authors": [
            {
                "name": "Tjark H Meyer",
                "org": "Institut f\u00fcr Organische und Biomolekulare Chemie, Georg-August-Universit\u00e4t G\u00f6ttingen, Tammannstra\u00dfe 2, 37077, Gottingen, Germany."
            },
            {
                "name": "Weiping Liu",
                "org": "Institut f\u00fcr Organische und Biomolekulare Chemie, Georg-August-Universit\u00e4t G\u00f6ttingen, Tammannstra\u00dfe 2, 37077, Gottingen, Germany."
            },
            {
                "name": "Milica Feldt",
                "org": "Institut f\u00fcr Organische und Biomolekulare Chemie, Georg-August-Universit\u00e4t G\u00f6ttingen, Tammannstra\u00dfe 2, 37077, Gottingen, Germany."
            },
            {
                "name": "Axel Wuttke",
                "org": "Institut f\u00fcr Physikalische Chemie, Georg-August-Universit\u00e4t G\u00f6ttingen, Tammannstra\u00dfe 6, 37077, Gottingen, Germany."
            },
            {
                "name": "Ricardo A Mata",
                "org": "Institut f\u00fcr Physikalische Chemie, Georg-August-Universit\u00e4t G\u00f6ttingen, Tammannstra\u00dfe 6, 37077, Gottingen, Germany."
            },
            {
                "name": "Lutz Ackermann",
                "org": "Institut f\u00fcr Organische und Biomolekulare Chemie, Georg-August-Universit\u00e4t G\u00f6ttingen, Tammannstra\u00dfe 2, 37077, Gottingen, Germany."
            }
        ],
        "venue": "Chemistry (Weinheim an der Bergstrasse, Germany)",
        "year": 2017
    },
    "0TlzGZ3x": {
        "id": "0TlzGZ3x",
        "title": "Manganese(I)-Catalyzed Dispersion-Enabled C\u2212H/C\u2212C Activation",
        "abstract": "C\u2212H/C\u2212C Functionalizations were achieved with the aid of a versatile manganese(I) catalyst. Thus, an organometallic manganese-catalyzed C\u2212H activation set the stage for silver-free C\u2212H/C\u2212C transformations with ample substrate scope and excellent levels of chemo-, site-, and diastereo-selectivities. The robust nature of the manganese(I) catalysis regime was reflected by the first C\u2212H/C\u2212C functionalization on amino acids under racemization-free reaction conditions. Detailed experimental and computational mechanistic studies provided strong evidence for a facile C\u2212H activation and a rate-determining C\u2212C cleavage, with considerable contribution from London dispersion interactions.",
        "keywords": "",
        "authors": [
            {
                "name": "Tjark H. Meyer",
                "org": "Institut f\u00fcr Organische und Biomolekulare Chemie Georg-August-Universit\u00e4t G\u00f6ttingen Tammannstra\u00dfe 2 37077 Gottingen Germany"
            },
            {
                "name": "Weiping Liu",
                "org": "Institut f\u00fcr Organische und Biomolekulare Chemie Georg-August-Universit\u00e4t G\u00f6ttingen Tammannstra\u00dfe 2 37077 Gottingen Germany"
            },
            {
                "name": "Milica Feldt",
                "org": "Institut f\u00fcr Organische und Biomolekulare Chemie Georg-August-Universit\u00e4t G\u00f6ttingen Tammannstra\u00dfe 2 37077 Gottingen Germany"
            },
            {
                "name": "Axel Wuttke",
                "org": "Institut f\u00fcr Physikalische Chemie Georg-August-Universit\u00e4t G\u00f6ttingen Tammannstra\u00dfe 6 37077 Gottingen Germany"
            },
            {
                "name": "Ricardo A. Mata",
                "org": "Institut f\u00fcr Physikalische Chemie Georg-August-Universit\u00e4t G\u00f6ttingen Tammannstra\u00dfe 6 37077 Gottingen Germany"
            },
            {
                "name": "Lutz Ackermann",
                "org": "Institut f\u00fcr Organische und Biomolekulare Chemie Georg-August-Universit\u00e4t G\u00f6ttingen Tammannstra\u00dfe 2 37077 Gottingen Germany"
            }
        ],
        "venue": "Chemistry: A European Journal",
        "year": 2017
    },
    "EOq9CUOs": {
        "id": "EOq9CUOs",
        "title": "MnCl2-Catalyzed C\u2212H Alkylations with Alkyl Halides",
        "abstract": "C\u2212H alkylations with challenging \u03b2-hydrogen-containing alkyl halides were accomplished with sustainable MnCl2 as the catalyst under phosphine-ligand-free conditions. The proximity-induced benzamide C\u2212H activation occurred with ample substrate scope through rate-determining C\u2212H metalation, also setting the stage for manganese-catalyzed oxidative C\u2212H methylations.",
        "keywords": "",
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "Institut f\u00fcr Organische und Biomolekulare Chemie Georg-August-Universit\u00e4t Tammannstra\u00dfe 2 37077 G\u00f6ttingen Germany"
            },
            {
                "name": "Gianpiero Cera",
                "org": "Institut f\u00fcr Organische und Biomolekulare Chemie Georg-August-Universit\u00e4t Tammannstra\u00dfe 2 37077 G\u00f6ttingen Germany"
            },
            {
                "name": "Jo\u00e3o C. A. Oliveira",
                "org": "Institut f\u00fcr Organische und Biomolekulare Chemie Georg-August-Universit\u00e4t Tammannstra\u00dfe 2 37077 G\u00f6ttingen Germany"
            },
            {
                "name": "Zhigao Shen",
                "org": "Institut f\u00fcr Organische und Biomolekulare Chemie Georg-August-Universit\u00e4t Tammannstra\u00dfe 2 37077 G\u00f6ttingen Germany"
            },
            {
                "name": "Lutz Ackermann",
                "org": "Institut f\u00fcr Organische und Biomolekulare Chemie Georg-August-Universit\u00e4t Tammannstra\u00dfe 2 37077 G\u00f6ttingen Germany"
            }
        ],
        "venue": "Chemistry: A European Journal",
        "year": 2017
    },
    "CdBMh4th": {
        "id": "CdBMh4th",
        "title": "Cobalt(III)-Catalyzed Allylation with Allyl Acetates by C\u2013H/C\u2013O Cleavage",
        "abstract": "",
        "keywords": [
            "cobalt"
        ],
        "authors": [
            {
                "name": "marc moselage",
                "org": ""
            },
            {
                "name": "nicolas sauermann",
                "org": ""
            },
            {
                "name": "julian koeller",
                "org": ""
            },
            {
                "name": "weiping liu",
                "org": ""
            },
            {
                "name": "dmitri gelman",
                "org": ""
            },
            {
                "name": "lutz ackermann",
                "org": ""
            }
        ],
        "venue": "Synlett",
        "year": 2015
    },
    "o07zJZ72": {
        "id": "o07zJZ72",
        "title": "MnCl 2 -Catalyzed C-H Alkylations with Alkyl Halides.",
        "abstract": "C-H alkylations with challenging \u03b2-hydrogen-containing alkyl halides were accomplished with sustainable MnCl as the catalyst under phosphine-ligand-free conditions. The proximity-induced benzamide C-H activation occurred with ample substrate scope through rate-determining C-H metalation, also setting the stage for manganese-catalyzed oxidative C-H methylations.",
        "keywords": [
            "C\u2212H activation",
            "alkylation",
            "manganese",
            "mechanism",
            "selectivity"
        ],
        "authors": [
            {
                "name": "Weiping Liu",
                "org": "Institut f\u00fcr Organische und Biomolekulare Chemie, Georg-August-Universit\u00e4t, Tammannstra\u00dfe 2, 37077, G\u00f6ttingen, Germany."
            },
            {
                "name": "Gianpiero Cera",
                "org": "Institut f\u00fcr Organische und Biomolekulare Chemie, Georg-August-Universit\u00e4t, Tammannstra\u00dfe 2, 37077, G\u00f6ttingen, Germany."
            },
            {
                "name": "Jo\u00e3o C A Oliveira",
                "org": "Institut f\u00fcr Organische und Biomolekulare Chemie, Georg-August-Universit\u00e4t, Tammannstra\u00dfe 2, 37077, G\u00f6ttingen, Germany."
            },
            {
                "name": "Zhigao Shen",
                "org": "Institut f\u00fcr Organische und Biomolekulare Chemie, Georg-August-Universit\u00e4t, Tammannstra\u00dfe 2, 37077, G\u00f6ttingen, Germany."
            },
            {
                "name": "Lutz Ackermann",
                "org": "Institut f\u00fcr Organische und Biomolekulare Chemie, Georg-August-Universit\u00e4t, Tammannstra\u00dfe 2, 37077, G\u00f6ttingen, Germany."
            }
        ],
        "venue": "Chemistry (Weinheim an der Bergstrasse, Germany)",
        "year": 2017
    },
    "LWOBJ9pn": {
        "id": "LWOBJ9pn",
        "title": "Data analysis of telephone consultations from parents of children with ostomy:the enlightenment",
        "abstract": "Objective To analyze demands of parents of ostomy children,and to provide information for clinical professionals to enrich health education contents and conduct extended service.Methods Pediatric surgical department provided 24 h telephone consultation service for parents of ostomy children,and a nurse was designated to receive consultations from parents of ostomy children and recorded such information as children\u2032s age,time of stoma formation,types of stoma,parents\u2032 consulting contents,nurses\u2032 answers into a self-designed record sheet.The consulting contents of parents of 50 ostomy children were classified into such six categories as feeding,waste leakage,information of stoma supplies,stoma complications,stoma irrigation and daily life issues.Results There were totally 124 times of telephone consultation,85(68.5%)ended with effective problem-solving.Most of the consultations(82.2%) came within one month after surgery.The consultation contents focused on stoma complications,waste leakage,information of stoma supplies,and feeding problems,which accounted for 29.0%,24.2%,22.6% and 19.4% respectively.Parents of children with intestinal stoma made 3.44 times of consultations per case,while parents of colostomy children made 2.03 times per case.Conclusion Ostomy children face quite a lot of problems.Consultation by telephone is useful to find out the demands of discharged ostomy children,resolve their parents\u2032 problems in time and improve their quality of life.It is of great significance for improving health education and conducting extended nursing services of ostomy children.",
        "keywords": [
            "intestinal stoma",
            "telephone counseling",
            "ostomy",
            "health education",
            "colostomy"
        ],
        "authors": [
            {
                "name": "Chen Jie",
                "org": "Surgical Department,Children\u2032s Hospital of Fudan University,Shanghai ,China"
            },
            {
                "name": "Zhang Yuxia",
                "org": "Surgical Department,Children\u2032s Hospital of Fudan University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Nursing Science",
        "year": 2010
    },
    "2Z4fjcCZ": {
        "id": "2Z4fjcCZ",
        "title": "Nursing care of thoraco-omphalopagus conjoined twins after operation of separation and transposition of the great arteries",
        "abstract": "",
        "keywords": [
            "Twins",
            "Conjoined",
            "Heart Defects",
            "Nursing Care",
            "Congenital"
        ],
        "authors": [
            {
                "name": "WANG Hui-mei",
                "org": ",et al"
            },
            {
                "name": "CHEN Jie",
                "org": ",et al"
            },
            {
                "name": "GU Ying",
                "org": ",et al"
            }
        ],
        "venue": "Chinese Journal of Nursing",
        "year": 2012
    },
    "VJXsC5bx": {
        "id": "VJXsC5bx",
        "title": "Effects of individualized bowel management of children with pseudo functional fecal incontinence",
        "abstract": "Objective To explore the effect of individualized bowel management of children with pseudo functional fecal incontinence. Methods A total of 40 children with functional fecal incontinence who sought medical help at an outpatient clinic were given indivi-dualized bowel management.The quality of life of children was assessed on 1st,2nd,and 3rd month,and their defecation condition was investigated with a self-designed questionnaire. Results The quality of life of children was significantly improved as the intervention progressed(P<0.01).At 3 months following intervention,the children moved their bowel 3.8 times per week on average,with the absence of fecal incontinence.All parents had accurate cognition on bowel management. Conclusion Individualized bowel management for children with functional fecal incontinence can effectively improve their quality of life,and ensure excellent treatment effect in the short term.",
        "keywords": [
            "pseudo fecal incontinence",
            "nursing care",
            "children",
            "quality of life",
            "bowel management",
            "defecation"
        ],
        "authors": [
            {
                "name": "Ren Ping",
                "org": "Nursing School,Fudan University,Shanghai ,China"
            },
            {
                "name": "Zhang Yuxia",
                "org": "Nursing School,Fudan University,Shanghai ,China"
            },
            {
                "name": "Chen Jie",
                "org": "Nursing School,Fudan University,Shanghai ,China"
            },
            {
                "name": "Gu Ying",
                "org": "Nursing School,Fudan University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Nursing Science",
        "year": 2013
    },
    "0cr2ziwq": {
        "id": "0cr2ziwq",
        "title": "Nursing care of a newborn with congenital ichthyosis",
        "abstract": "",
        "keywords": [
            "Infant",
            "Newborn",
            "Nursing Care",
            "Ichthyosis Bullosa of Siemens"
        ],
        "authors": [
            {
                "name": "REN Ping",
                "org": ""
            },
            {
                "name": "ZHANG Yu-xia",
                "org": ""
            },
            {
                "name": "CHEN Jie",
                "org": ""
            }
        ],
        "venue": "Chinese Journal of Nursing",
        "year": 2013
    },
    "ym5d00XP": {
        "id": "ym5d00XP",
        "title": "Wound management for a neonate with epidermolysis bullosa",
        "abstract": "",
        "keywords": [
            "Infant",
            "Newborn",
            "Nursing Care",
            "Epidermolysis Bullosa"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": ""
            },
            {
                "name": "WU Wei-qin",
                "org": ""
            },
            {
                "name": "ZHANG Yu-xia",
                "org": ""
            }
        ],
        "venue": "Chinese Journal of Nursing",
        "year": 2012
    },
    "Bp0RYdV5": {
        "id": "Bp0RYdV5",
        "title": "Analysis of 149 children with enterostomy complications and nursing care of them",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Chen Jie",
                "org": "Affiliated Children's Hospital of Fudan University,Shanghai  China"
            },
            {
                "name": "Ma Lili",
                "org": "Affiliated Children's Hospital of Fudan University,Shanghai  China"
            },
            {
                "name": "Chen Lin",
                "org": "Affiliated Children's Hospital of Fudan University,Shanghai  China"
            }
        ],
        "venue": "Chinese Nursing Research",
        "year": 2011
    },
    "49xKz8iF": {
        "id": "49xKz8iF",
        "title": "Research progress in preoperative fasting of pediatric patients scheduled for an elective operation",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Li Bian",
                "org": ""
            },
            {
                "name": "Zhang Yuxia",
                "org": ""
            },
            {
                "name": "Chen Jie",
                "org": ""
            }
        ],
        "venue": "Journal of Nursing Science",
        "year": 2012
    },
    "WVuzksE8": {
        "id": "WVuzksE8",
        "title": "Influence of individualized intestinal management on improvement of anal function of children with pseudo fecal incontinence",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Ren Ping",
                "org": "Children's Hospital of Fudan University"
            },
            {
                "name": "Zhang Yuxia",
                "org": "Children's Hospital of Fudan University"
            },
            {
                "name": "Chen Jie",
                "org": "Children's Hospital of Fudan University"
            },
            {
                "name": "g Y",
                "org": "Children's Hospital of Fudan University"
            }
        ],
        "venue": "Chinese Nursing Research",
        "year": 2013
    },
    "HfLqamcE": {
        "id": "HfLqamcE",
        "title": "Bowel management for the treatment of pediatric fecal incontinence: an review",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Ren Ping",
                "org": ""
            },
            {
                "name": "Zhang Yuxia",
                "org": ""
            },
            {
                "name": "Chen Jie",
                "org": ""
            },
            {
                "name": "Wang Wei",
                "org": ""
            }
        ],
        "venue": "Journal of Nursing Science",
        "year": 2012
    },
    "mVa5U5R3": {
        "id": "mVa5U5R3",
        "title": "Target localization and identification algorithm for Ultra WideBand through-wall radar",
        "abstract": "The Ultra WideBand Short-Pulse (UWB-SP) Radar used for detecting targets is a promising technique in counter-terrorism, calamity rescue scenarios, urban-warfare and other fields as its high range resolution, strong penetrating power and good resolving ability. The detecting of targets through wall is an important application based on UWB-SP Radar. As the SEABED algorithm (a new target localization and identification algorithm) based on the UWB-SP Radar is not applicable for that application, this paper proposes a new algorithm to offset the influence brought from the wall firstly and then obtain the image of targets behind the wall by using the SEABED algorithm. Simulation results show that the proposed algorithm can remove the effect of the wall visibly and the imaging results can estimate the shape of targets well.",
        "keywords": [
            "SEABED algorithm",
            "Target localization",
            "Target shape imaging",
            "UWB-SP Radar"
        ],
        "authors": [
            {
                "name": "Wu Shi-you",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            },
            {
                "name": "Qiong Huang",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            },
            {
                "name": "Jie Chen",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            },
            {
                "name": "Meng Sheng-wei",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            },
            {
                "name": "Fang Guang-you",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            },
            {
                "name": "Yin He-jun",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            }
        ],
        "venue": "Dianzi Yu Xinxi Xuebao/Journal of Electronics and Information Technology",
        "year": 2010
    },
    "K7JSBfAH": {
        "id": "K7JSBfAH",
        "title": "A New Tracking and Imaging Algorithm of Moving Target for Ultra Wideband Through Wall Radar",
        "abstract": "The Ultra Wide-Band Short-Pulse(UWB-SP) radar used for detecting targets is a promising technique in fire rescue operations,police awareness,urban-warfare,life-threatening and other fields,and it can be used for noncontact measurement of the tracking and imaging of moving target behind walls.As the Shape Estimation Algorithm based on BST(Boundary Scattering Transform) and Extraction of Directly scattered waves(SEABED) algorithm(a new target localization and identification algorithm) based on the UWB-SP radar is not applicable for that application,this paper proposes a new algorithm to obtain the target shape imaging and track it synchronously using triangle localization method and the difference of time delay.In this paper,the proposed algorithm based on a system model built in the near field can effectively estimate the velocity and track of moving target with the imaging result.Simulation results show that the effect of the wall can be removed visibly and the purpose of the imaging and tracking of moving target can be realized well.",
        "keywords": [
            "Shape Estimation Algorithm based on BST(Boundary Scattering Transform) and Extraction of Directly scattered waves(SEABED) algorithm",
            "Ultra Wide-Band Short-Pulse(UWB-SP) radar",
            "Moving target",
            "Tracking and imaging",
            "Difference of time delay"
        ],
        "authors": [
            {
                "name": "Wu Shi-you",
                "org": ""
            },
            {
                "name": "Chen Jie",
                "org": ""
            },
            {
                "name": "Meng Sheng-wei",
                "org": ""
            },
            {
                "name": "Fang Guang-you",
                "org": ""
            },
            {
                "name": "Yin He-jun",
                "org": ""
            }
        ],
        "venue": "Journal of Electronics & Information Technology",
        "year": 2012
    },
    "Brpo5UfX": {
        "id": "Brpo5UfX",
        "title": "A non-coherent imaging approach for ultra-wideband through-wall radar",
        "abstract": "Ultra-wideband (UWB) through-wall imaging radar is a promising technique and can be widely used for detecting and locating moving people through obstacles. Through-wall imaging radar employs coherent and non-coherent imaging techniques. In this paper we focus on a one-transmitter two-receiver non-coherent radar system. Analytical formulations of the target localization are given under the condition of both the absence of the wall and the presence of the wall. This paper also provides the cross-range resolution analysis and the supporting FDTD simulation results.",
        "keywords": [
            "trilateration",
            "ultra-wideband",
            "non-coherent",
            "through-wall imaging radar"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": " Institute of Electronics, Chinese Academy of Sciences, Beijing , China; Graduate University of Chinese Academy of Sciences, Beijing , China"
            },
            {
                "name": "FANG Guang-You",
                "org": " Institute of Electronics, Chinese Academy of Sciences, Beijing , China"
            },
            {
                "name": "LI Fang",
                "org": " Institute of Electronics, Chinese Academy of Sciences, Beijing , China"
            }
        ],
        "venue": "Journal of the Graduate School of the Chinese Academy of Sciences",
        "year": 2007
    },
    "VEMheNJ2": {
        "id": "VEMheNJ2",
        "title": "Microwave Transmission Method to Detecting Permittivity of Wheat",
        "abstract": "This paper adopts microwave transmission method to measurement complex permittivity of wheat.The principle of the microwave transmission method is introduced.The dielectric constant and loss factor of wheat is measured between 1GHz and 8GHz detection frequencies.According to the experiment results,the regulation of complex permittivity with frequency is presented.The error between the experiment results and the publication data from USDA is less than 4%.",
        "keywords": [
            "loss factor",
            "relative complex permittivity",
            "microwave measurements",
            "dielectric constant"
        ],
        "authors": [
            {
                "name": "Qin Yao",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China;Graduate School,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "Chen Jie",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "Fang Guangyou",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "Yin Hejun",
                "org": "Chinese Academy of Sciences,Beijing ,China"
            }
        ],
        "venue": "Journal of Agricultural Mechanization Research",
        "year": 2010
    },
    "W9JqZ2CM": {
        "id": "W9JqZ2CM",
        "title": "Tracking and Imaging Algorithm for Walking Human Bodies by UWB Radar System",
        "abstract": "The Ultra WideBand(UWB) Radar is a promising candidate for detecting human bodies in many fields such as urban-warfare,counter-terrorism and calamity rescue scenarios.Conventional UWB imaging algorithm can not meet the demand in the capability of targets recognition and calculation efficiency.This paper proposed a novel algorithm based on high-speed SEABED algorithm for UWB radar systems in which walking motion was used to replace antenna scanning by assuming a system model.The effectiveness and feasibility of the algorithm is demonstrated via simulated and experimental results.It is shown that the proposed algorithm features simple hardware requirement,low calculation,and high imaging precision,and it can be used to estimate the velocity,image and track walking human bodies.",
        "keywords": [
            "moving targets tracking",
            "SEABED algorithm",
            "ultra wideband(UWB) radar",
            "target shape imaging",
            "boundary scattering transform(BST)"
        ],
        "authors": [
            {
                "name": "HUANG Qiong",
                "org": "No.802 Institute of Shanghai Academy of Spaceflight Technology,Shanghai ,China;Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "WU Shi-you",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "MENG Sheng-wei",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China;Harbin Institute of Technology,Harbin,Heilongjiang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "FANG Guang-you",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            }
        ],
        "venue": "Acta Electronica Sinica",
        "year": 2011
    },
    "pHlztU2k": {
        "id": "pHlztU2k",
        "title": "Research on moving target tracking and imaging algorithm for ultra wideband through-wall radar",
        "abstract": "Detection and tracking of human targets behind walls with Ultra Wideband Through-Wall Radar (UWB TWR) have important application value in urban area operations, counter-terrorism and search-and-rescue missions. TWR signal processing consists of two key parts-moving target detection (MTD) and imaging algorithm. An adaptive background subtraction method for extracting the information of moving targets is presented in this paper, which outperforms conventional MTD techniques. Then an improved BP algorithm is also introduced, which considers the presence of walls. FDTD numerical simulations and experimental results validate that the proposed algorithm can be used to track and image moving targets behind walls. The results also show that the proposed algorithm has the characteristics of simple antenna array requirement, high position accuracy and real time imaging.",
        "keywords": [
            "Back-projection (BP)",
            "Moving target detection (MTD)",
            "Through-wall imaging",
            "Ultra wideband (UWB) radar"
        ],
        "authors": [
            {
                "name": "Shengwei Meng",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            },
            {
                "name": "Qiong Huang",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            },
            {
                "name": "ShiYou Wu",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            },
            {
                "name": "Jie Chen",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            },
            {
                "name": "Guangyou Fang",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            }
        ],
        "venue": "Yi Qi Yi Biao Xue Bao/Chinese Journal of Scientific Instrument",
        "year": 2010
    },
    "cL1Ol1gX": {
        "id": "cL1Ol1gX",
        "title": "The application of time domain beamforming to ultra-wideband through-wall imaging radar",
        "abstract": "Ultra-WideBand (UWB) through-wall imaging radar is a promising technique and can be widely used for detecting and locating moving people through obstacles. In this paper, time domain beamforming method is presented for UWB through-wall imaging applications. The propagating wave slows down, encounters refraction and is attenuated as it passes through the wall. Firstly, the travel time is calculated from the antenna to the target in closed form based on the refraction model. Next, the beamformer design is presented, which incorporates the wall effects. Finally, Finite-Difference Time-Domain is used to demonstrate the efficacy of beamforming method and the impact of incorrect estimates of the wall thickness and dielectric constant on performance is also considered.",
        "keywords": [
            "Imaging radar",
            "Through-wall imaging radar",
            "Time domain beamforming",
            "Ultra-WideBand (UWB)"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            },
            {
                "name": "Fang Guang-you",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            },
            {
                "name": "Fang Li",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            }
        ],
        "venue": "Dianzi Yu Xinxi Xuebao/Journal of Electronics and Information Technology",
        "year": 2008
    },
    "2XliL7jz": {
        "id": "2XliL7jz",
        "title": "Non-Destructive Detection of Barn Reserves Information",
        "abstract": "A non-destructive testing method to detect reserves of a grain barn is put forward in this paper.According to the relationship between permittivity and bulk density of grain,velocity tomography technology is used to estimate grain permittivity,and gets bulk density.Then velocity tomography technology is adopted to image the practical height of grain and the size and shape of the unconventionality objects in the barn.With the information of the practical height and the size of unconventionality objects,the practical bulk of grain can be achieved,and then the practical reserves can be estimated.FDTD and Tikhonov regularization algorithms are used to do forward imitate and inversion calculation.The simulating results show that using the radar tomography method to detect grain reserves information of a barn is valid.",
        "keywords": [
            "inversion",
            "Tikhonov regularization",
            "density estimate",
            "permittivity",
            "radar tomography image",
            "FDTD",
            "reserves detection"
        ],
        "authors": [
            {
                "name": "Qin Yao",
                "org": "Institute of Electronics,Chinese Academy of Science 1,Beijing ;Graduate School,Chinese Academy of Science 2,Beijing "
            },
            {
                "name": "Chen Jie",
                "org": "Institute of Electronics,Chinese Academy of Science 1,Beijing "
            },
            {
                "name": "Fang Guangyou",
                "org": "Institute of Electronics,Chinese Academy of Science 1,Beijing "
            }
        ],
        "venue": "Journal of the Chinese Cereals and Oils Association",
        "year": 2010
    },
    "1MizEk9W": {
        "id": "1MizEk9W",
        "title": "A Fast Imaging Algorithm for UWB Through-Wall Radar",
        "abstract": "The Ultra-WideBand Through-Wall Radar (UWB TWR) has become a keen research topic in recent years because of the urgent needs of counter-terrorism and calamity rescue, etc. Conventional UWB imaging algorithm can not meet the demand in the capability of targets recognition and calculation efficiency. The Shape Estimation Algorithm based on the Boundary scattering transform and Extraction of Directly scattered waves (SEABED) can be used to reconstruct target shape, but it is restricted by the presence of the wall in the application of TWR. In this paper, a novel envelop curve algorithm is presented to adapt to the special conditions in TWR. To realize imaging of the target boundary, the algorithm extracts the quasi wavefront from the received signals and computes the envelop curve of a group of circles. FDTD numerical simulations validate that the algorithm can be used to obtain two-dimensional images of targets behind walls. The position error by the influence of the walls is also analyzed.",
        "keywords": [
            "Envelop curve",
            "Inverse Boundary Scattering Transform (IBST)",
            "Through-wall imaging",
            "Ultra WideBand (UWB) radar"
        ],
        "authors": [
            {
                "name": "Huang Qiong",
                "org": "Institute of Electronics, Chinese Academy of Sciences, Beijing , China"
            },
            {
                "name": "Chen Jie",
                "org": "Institute of Electronics, Chinese Academy of Sciences, Beijing , China"
            },
            {
                "name": "Shengwei Meng",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            },
            {
                "name": "Guangyou Fang",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            }
        ],
        "venue": "Journal of Electronics & Information Technology",
        "year": 2009
    },
    "XzrdDcLR": {
        "id": "XzrdDcLR",
        "title": "Spectrum fitting method for improving the vertical resolution of ground penetrating radar",
        "abstract": "The resolution of ground penetrating radar restricts its recognition power. According to the analysis of thin layer reflection wave, this paper presents a method using spectrum information to improve the vertical resolution of GPR. At first, the transmission model of electromagnetic wave in layered media is studied, and then the spectrum transmission function of GPR in four layers is built. The spectrum of the echo wave is fitted through computing the echo spectrums for different thickness layers. According to the fitting error curve, the thickness of the target layer can be picked up. This method avoids the shortcomings of traditional deconvolution method. Through processing the simulation data and experiment data, the effectiveness of this method in improving the vertical resolution of GPR is proved.",
        "keywords": [
            "Fitting",
            "Ground penetrating radar",
            "Spectrum",
            "Vertical resolution"
        ],
        "authors": [
            {
                "name": "Yao Qin",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            },
            {
                "name": "Jie Chen",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            },
            {
                "name": "Guangyou Fang",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            }
        ],
        "venue": "Yi Qi Yi Biao Xue Bao/Chinese Journal of Scientific Instrument",
        "year": 2010
    },
    "GSQc5YAh": {
        "id": "GSQc5YAh",
        "title": "3-D Fast Imaging Algorithm for Ultra-wideBand Through-Wall Radar",
        "abstract": "The ultra-wideband through-wall radar(UWB TWR) is a novel real-time imaging radar system and can detect the suspicious objects without intrusion and surveil targets behind walls.Nowadays it can be widely used for urban-warfare,counter-terrorism and hostage rescue.Since TWR is a real time system with a strict requirement on processing time,conventional imaging algorithms cannot meet the demands of the calculation efficiency.Basic theories and implementations of the imaging algorithm based on the inverse boundary scattering transform(IBST)are presented.With finite difference time-domain(FDTD) numerical simulations,it is validated that the algorithm can be used to obtain three-dimensional(3-D) images of targets behind walls,and the position error caused of the presence of the wall is analyzed.Results show that the calculation efficiency by the proposed algorithm is much higher than that of the back-projection imaging algorithm,especially in 3-D imaging.And the target surface can be exactly reconstructed.",
        "keywords": [
            "inverse boundary scattering transform",
            "ultra-wideband radar",
            "positioning error",
            "through-wall imaging"
        ],
        "authors": [
            {
                "name": "Huang Qiong",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing,,China"
            },
            {
                "name": "Chen Jie",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing,,China"
            },
            {
                "name": "Meng Shengwei",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing,,China"
            },
            {
                "name": "Fang Guangyou",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing,,China"
            }
        ],
        "venue": "Journal of Data Acquisition and Processing",
        "year": 2009
    },
    "QxipKKL5": {
        "id": "QxipKKL5",
        "title": "Research on thin-layer recognition technique based on the spectrum inversion method of Ground Penetrating Radar",
        "abstract": "Two parameters are normally employed to evaluate recognition ability of the Ground Penetrating Radar (GPR) for the thin-layer: the least recognition thickness and the reflectance recognition precision. In this paper, the spectrum inversion method is used to improve the recognition ability of the GPR. The spectrum transmission function of the multilayer media is firstly deduced, and the forward model of the reflecting wave spectrum is obtained. Then the two parameters are inversed by using the damp least-squares algorithm. The experiment demonstrates that the method can identify the layer effectively with a thickness less then one-eighth wavelength.",
        "keywords": [
            "Ground Penetrating Radar (GPR)",
            "Reflectance coefficient",
            "Spectrum inversion",
            "Thickness",
            "Thin-layer"
        ],
        "authors": [
            {
                "name": "Yao Qin",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            },
            {
                "name": "Jie Chen",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            },
            {
                "name": "Fang Guang-you",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            },
            {
                "name": "Yin He-jun",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            }
        ],
        "venue": "Dianzi Yu Xinxi Xuebao/Journal of Electronics and Information Technology",
        "year": 2010
    },
    "qYhvd1eo": {
        "id": "qYhvd1eo",
        "title": "Ground penetrating radar imaging based on f-k migration and minimum entropy method",
        "abstract": "Estimation of position and shape of the object subsurface is one of the main problems in Ground Penetrating Radar (GPR) application. Migration method in domain of seismic techniques is effective to locate and reshape the object. The electromagnetic wave velocity parameter is the main factor influencing the precision of location. In this paper, the GPR images are handled with frequency-wavenumber migration on the base of applying minimum entropy method to estimate velocity parameter. Experimental results of simulation and GPR data prove its feasibility and validity.",
        "keywords": [
            "Frequency-wavenumber migration",
            "Minimum entropy",
            "Velocity estimation"
        ],
        "authors": [
            {
                "name": "Xiu Zhi-jie",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            },
            {
                "name": "Jie Chen",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            },
            {
                "name": "Fang Guang-you",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            },
            {
                "name": "Fang Li",
                "org": "Institute of Electronics Chinese Academy of Sciences(Institute of Electronics,Inst. of Electronics,Inst of Electronics),Beijing,China"
            }
        ],
        "venue": "Dianzi Yu Xinxi Xuebao/Journal of Electronics and Information Technology",
        "year": 2007
    },
    "qVzvL9KN": {
        "id": "qVzvL9KN",
        "title": "Radar tomography technology to detect reserves of barn",
        "abstract": "Radar tomography technology as a non-destructive testing method is proposed to detect reserves of barn. The permittivity of grain in the barn can be obtained by velocity and attenuation tomography inversion method. Then the density of the grain can be calculated based on the relationship between permittivity and grain density. At the same time, the actual height of grain and the shape of unconventionality objects in the barn can be imaged by velocity and attenuation tomography image method. Actual bulk of the grain can be calculated with the information of actual height and the size of unconventional objects. Based on the density and bulk information of barn, the practical reserves can be achieved. Simulation results verify the effectiveness of the proposed method. \u00a92010 by Editorial Department of Chinese Journal of Radio Science.",
        "keywords": [
            "Attenuation tomography",
            "Permittivity inversion",
            "Reserves detection",
            "Tomography image",
            "Velocity tomography"
        ],
        "authors": [
            {
                "name": "Yao Qin",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "Jie Chen",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "FANG Guang-you",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "YIN He-jun",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            }
        ],
        "venue": "Dianbo Kexue Xuebao/Chinese Journal of Radio Science",
        "year": 2010
    },
    "GX3rxbYI": {
        "id": "GX3rxbYI",
        "title": "Investigation of Approval Degree of Breast Conserving Therapy and Breast Reconstruction of Women with Breast Diseases",
        "abstract": "Objective To study the cause of the low rate of breast conservation and reconstruction by investigating the approval degree of breast conserving therapy and breast reconstruction of women with breast diseases,to help the breast surgeons make better communication with the patients and make more pertinent choices of therapeutic methods.Methods The age,occupation,educational background,the attitudes towards breast conserving therapy and breast reconstruction,and the choice of operative method of breast reconstruction of 139 patients with breast cancer and 224 patients with benign breast disease were investigated by questionnaire.Results In breast cancer group,23.9%(28/117) of patients chose breast conserving therapy and 35.9%(42/117) of patients chose breast reconstruction,while the rates of breast conservation and reconstruction were 53.3%(106/199) and 63.8%(127/199) in benign breast disease group.In both groups,the higher rates of breast conservation and reconstruction were associated with better educational background(in breast cancer group: P=0.029,P=0.296;in benign breast disease group: P=0.081,P=0.019) and lower age(all P<0.05).Patients engaged in commerce showed higher rates of breast conservation and reconstruction(in breast cancer group: P=0.013,P=0.042;in benign breast disease group: P=0.032,P=0.044).Age,occupation or educational background was not related with the choice of operative method of breast reconstruction(P>0.05).Conclusions Patients with lower age,better educational background,and better job condition have stronger desire of breast conservation and reconstruction.Breast surgeons should enhance communication with those patients about relevant information of breast conservation and reconstruction to make the more pertinent choice of therapeutic methods.",
        "keywords": [
            "Breast reconstruction",
            "Breast conserving operation",
            "Approval degree",
            "Questionnaire"
        ],
        "authors": [
            {
                "name": "ZHANG Xin",
                "org": ".1.Department of Thyroid and Breast Surgery,West China Hospital,Chengdu ,China;Department of Breast Surgery,Sichuan Cancer Hospital,Chengdu ,China"
            },
            {
                "name": "ZHANG Pu-rong",
                "org": "Department of Breast Surgery,Sichuan Cancer Hospital,Chengdu ,China"
            },
            {
                "name": "CHEN Jie",
                "org": ".1.Department of Thyroid and Breast Surgery,West China Hospital,Chengdu ,China"
            },
            {
                "name": "ZHENG Jie",
                "org": "Department of Breast Surgery,Sichuan Cancer Hospital,Chengdu ,China"
            },
            {
                "name": "L\u00fc Qing",
                "org": ".1.Department of Thyroid and Breast Surgery,West China Hospital,Chengdu ,China"
            }
        ],
        "venue": "Chinese Journal of Bases and Clinics in General Surgery",
        "year": 2010
    },
    "zwflBo69": {
        "id": "zwflBo69",
        "title": "Upper Limb Edema in the Short-term Clinical Observation of Fitness Ball Exercise Treatment of Breast Cancer after Radical Surgery",
        "abstract": "Objective:To explore the effect of compression therapy on upper extremity lymph edema post mastectomy of breast cancer patients,and to evaluate its clinical significance by excise of fitness steel ball.Methods:Sixty patients were randomly divided into test groups and control groups,every groups had 30 cases respectively.Patients in test groups received excise of fitness steel ball,and those in the control group received traditional recovery methods.Results:Two groups who experienced mastectomy all were with light to moderate upper extremity lymph edema at first 1 day after operation(P<0.05),the degree of edema in the test groups were significantly lower than that in the control groups following time after operation(P<0.05).Conclusion:To the breast cancer patients who experienced mastectomy and with upper extremity lymph edema after operation,excise of fitness steel ball is effective in a short time.",
        "keywords": [
            "operation",
            "breast cancer",
            "excise of fitness steel ball",
            "edema of the upper extremity"
        ],
        "authors": [
            {
                "name": "CHEN Bo",
                "org": ",et al.1.Department of General Surgery,General Hospital of Sichuan Petroleum,Chengdu "
            },
            {
                "name": "KONG Fei-teng",
                "org": "Department of Pediatric Surgery"
            },
            {
                "name": "CHEN Jie",
                "org": "Department of General Surgery,West China Hospital,Sichuan University,Chengdu ,China)"
            }
        ],
        "venue": "West China Medical Journal",
        "year": 2009
    },
    "VeVfg6VI": {
        "id": "VeVfg6VI",
        "title": "Breast reconstruction after skin-sparing mastectomy or nipple-sparing mastectomy for breast cancer]",
        "abstract": "To evaluate the feasibility, oncological safety, and aesthetic result of skin-spring mastectomy (SSM) or nipple-spring mastectomy (NSM) in breast reconstruction of implant (permanent gel or expander) for breast cancer patients who were not fit for the breast conserving surgery (BCS).Between October 2005 and July 2011, 89 women with breast caner underwent SSM or NSM, with an average age of 42.4 years (range, 19-55 years) and an average disease duration of 5.7 months (range, 1-24 months). The pathological examination revealed invasive ductal carcinoma in 55 cases, ductal carcinoma in situ (DCIS) in 15 cases, invasive ductal carcinoma + DCIS in 8 cases, DCIS with infiltration in 10 cases, and occult breast cancer in 1 case. According to tumor staging criterion of American Joint Committee on Cancer (AJCC), 15 cases were rated as stage 0, 51 cases as stage I, 22 cases as stage II, and 1 case as unclear. Finally, 33 patients underwent SSM and 56 patients underwent NSM according to the location and diameter of tumor and the infiltration of tumor to nipple. Secondary breast reconstruction was performed with permanent gel replacement after axillary lymph node dissection in 9 patients with positive sentinel lymph node and 1 patient with occult breast cancer; immediate breast reconstruction was performed with permanent gel in the other patients. All the patients received the chemotherapy or/and radiotherapy according to the National Comprehensive Cancer Network (NCCN) guideline.Complications occurred in 5 patients undergoing breast reconstruction of permanent gel after NSM, including 1 case of haemorrhage, 2 cases of infection, and 2 cases of local skin necrosis. Primary healing of incision was obtained in the others. No nipple necrosis was observed in patients undergoing NSM. All the patients were followed up 14-88 months (median, 40 months). At 10 months after operation, the aesthetic results were excellent in 40 cases, good in 33 cases, fair in 14 cases, and poor in 2 cases, with an excellent and good rate of 82%. No recurrence or metastasis was found during follow-up.The SSM or NSM is feasible and oncological safe for patients who are not fit for BCS, with satisfactory aesthetic result.",
        "keywords": [
            "breast cancer breast mastectomy breast reconstruction permanent gel expander"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": ".Department of Thyroid and Breast Surgery,West China Hospital,Sichuan University,Chengdu Sichuan,,P.R.China."
            },
            {
                "name": "Qing L\u00fc",
                "org": ".Department of Thyroid and Breast Surgery,West China Hospital,Sichuan University,Chengdu Sichuan,,P.R.China."
            },
            {
                "name": "Xiaodong Wang",
                "org": ".Department of Thyroid and Breast Surgery,West China Hospital,Sichuan University,Chengdu Sichuan,,P.R.China."
            },
            {
                "name": "Hongjiang Li",
                "org": ".Department of Thyroid and Breast Surgery,West China Hospital,Sichuan University,Chengdu Sichuan,,P.R.China."
            },
            {
                "name": "Yujuan Chen",
                "org": ".Department of Thyroid and Breast Surgery,West China Hospital,Sichuan University,Chengdu Sichuan,,P.R.China."
            },
            {
                "name": "Xiaoqin Yang",
                "org": ".Department of Thyroid and Breast Surgery,West China Hospital,Sichuan University,Chengdu Sichuan,,P.R.China."
            },
            {
                "name": "Helin Zeng",
                "org": ".Department of Thyroid and Breast Surgery,West China Hospital,Sichuan University,Chengdu Sichuan,,P.R.China."
            }
        ],
        "venue": "Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery",
        "year": 2013
    },
    "RLjZDYHy": {
        "id": "RLjZDYHy",
        "title": "Ventral urethroplasty for postoperative urethral stricture in patients with hypospadias]",
        "abstract": "Objective To investigate the effect of ventral urethroplasty for postoperative anastomotic stricture in patients with hypospadias.Methods From August 2000 to December 2005,20 patients with anastomotic stricture after hypospadias repair were treated with ventral urethroplasty.The age ranged from 2 to 27 years with an average of 6.4 years.All patients showed dysuria after operation.Main clinical manifestation included dysuria and acraturesis.Interruption of urinary stream occurred in 17 cases;of them,3 cases had urinary stasis and 4 cases had frequent micturition,urgent micturition and pain in urination.Urethrography and cystourethrography showed 0.5-1.0 cm stricture with proximal dilation of urethra in 16 cases and obvious diverticularization in 9 cases.Urine routine examination showed that white blood cell was \u25a0 to \ue072 in 16 cases and pus cell was \u00b1 to \u25a0 in 13 cases.Results Twenty cases were followed up 2 months to 4 years(mean 2.3 years).All the cases achieved good results in urination with normosthenuria and normal force of urinary stream.No recurrent stricture,urethrocutaneous fistula,or penile curvature occurred.The cosmesis was satisfactory,and the results of urine routine examination was normal.Conclusion Ventral urethroplasty for postoperative anastomotic stricture in patients with hypospadias is a simple and effective procedure.",
        "keywords": [
            "Hypospadias Complication Urethral stricture Ventral urethroplasty"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Department of Surgery, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, PR China. chenjiedoctor@126.com"
            },
            {
                "name": "Yunman Tang",
                "org": ",et al.Department of Surgery,West China Hospital,Sichuan University,Chengdu Sichuan,,P.R.China"
            },
            {
                "name": "Minghe Wang",
                "org": ",et al.Department of Surgery,West China Hospital,Sichuan University,Chengdu Sichuan,,P.R.China"
            }
        ],
        "venue": "Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery",
        "year": 2007
    },
    "3fdn0548": {
        "id": "3fdn0548",
        "title": "A clinical study on regional lymphatic chemotherapy using an activated carbon nanoparticle-epirubicin in patients with breast cancer.",
        "abstract": "The purpose of this study was to understand the short-term therapeutic effects of an activated carbon nanoparticle-epirubicin suspension for regional lymphatic chemotherapy in patients with breast cancer. One hundred and twenty patients with stage I, II, or III primary breast cancer were randomly divided into three groups: the lymphatic chemotherapy group using the activated carbon nanoparticle-epirubicin suspension, the epirubicin control group, and the activated carbon control group. Each group of 40 patients was further divided into two subgroups with the drug injected either 24 or 48 h before surgery. The terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling (TUNEL) assay was used to determine cancer cell apoptotic indices in metastatic lymph nodes. The epirubicin concentration in the black-stained lymph nodes in the lymphatic chemotherapy treatment group was 4,144.64 \u00b1 2,426.44 ng/g, which is significantly higher than in the epirubicin control group (335.87 \u00b1 212.82 ng/g, P < 0.001). The plasma epirubicin concentrations at 0.5, 1.5, and 24 h postinjection in the regional lymphatic chemotherapy treatment group were significantly lower than in the epirubicin control group (P < 0.001). Tolerable mild pain was observed at the injection area after administration of the epirubicin-activated carbon nanoparticle suspension. No regional necrosis or adverse effects were found. The TUNEL assay demonstrated that there was no significant difference in the apoptotic indices in the metastatic lymph nodes from the three groups. Performing lymphatic chemotherapy by regionally injecting the epirubicin-activated carbon nanoparticle suspension could significantly enhance the drug concentration in the stained lymph nodes and lower the plasma drug concentration. The epirubicin-activated carbon nanoparticle suspension has the ability to release the drug slowly in the lymph nodes and, as a result, can prolong the chemotherapeutic effects.",
        "keywords": [],
        "authors": [
            {
                "name": "Qian Yang",
                "org": "Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Xiao-dong Wang",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Chun-xiang Tian",
                "org": ""
            },
            {
                "name": "Hong-jiang Li",
                "org": ""
            },
            {
                "name": "Yu-Juan Chen",
                "org": ""
            },
            {
                "name": "Qing Lv",
                "org": ""
            }
        ],
        "venue": "Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine",
        "year": 2012
    },
    "VAqaj9eW": {
        "id": "VAqaj9eW",
        "title": "The Property with Adsorption and Slow Release of Carbon Nanoparticles Suspension Injection for Epirubicin Solution in Vitro",
        "abstract": "Objective To determine the best matching concentration of carbon nanoparticles suspension injection adsorb epirubicin by measuring the combination ratio of carbon nanoparticles suspension injection combined with epirubicin under different matching conditions.And then,to prove the adsorbability of carbon nanoparticles suspension injection adsorb epirubicin in vitro.Methods Firstly,epirubicin-carbon suspension of different concentrations will be prepared.The second,high performance liquid chromatography mass spectrometry (LC-MS) was used to assay the concentration of free epirubicin,and calculate the content of epirubicin that was combinated with carbon nanoparticles suspension injection.The difference of the ratio of carbon nanoparticles suspension injection combined with epirubicin under different matching conditions will be compared in the end.Results The combination ratio of carbon nanoparticles suspension injection combined with epirubicin solution of 5,10,and 15 mg/ml were 85.6%,85.7%,and 31.8%,respectively.Conclusions The adsorbability of carbon nanoparticles suspension injection adsorb epirubicin is favourable in vitro.Best matching concentration of carbon nanoparticles suspension injection adsorb epirubicin may be epirubicin solution of 5-10 mg/ml.",
        "keywords": [
            "Combination ratio",
            "Carbon nanoparticles suspension injection",
            "Epirubicin"
        ],
        "authors": [
            {
                "name": "YANG Qian",
                "org": ",LU Qing. Department of Thyroid and Breast Surgery,West China Hospital,Sichuan University,Chengdu ,Sichuan Province,China"
            },
            {
                "name": "CHEN Jie",
                "org": ",LU Qing. Department of Thyroid and Breast Surgery,West China Hospital,Sichuan University,Chengdu ,Sichuan Province,China"
            },
            {
                "name": "TIAN Chun-xiang",
                "org": ",LU Qing. Department of Thyroid and Breast Surgery,West China Hospital,Sichuan University,Chengdu ,Sichuan Province,China"
            },
            {
                "name": "WANG Rong",
                "org": ",LU Qing. Department of Thyroid and Breast Surgery,West China Hospital,Sichuan University,Chengdu ,Sichuan Province,China"
            },
            {
                "name": "FAN Xue-Jiao",
                "org": ",LU Qing. Department of Thyroid and Breast Surgery,West China Hospital,Sichuan University,Chengdu ,Sichuan Province,China"
            }
        ],
        "venue": "Chinese Journal of Bases and Clinics in General Surgery",
        "year": 2012
    },
    "H0BPtP3t": {
        "id": "H0BPtP3t",
        "title": "Clinical Application of Combination of Radiolabeled Colloid and Blue Dye in Sentinel Lymph Node Biopsy for Early-Stage Breast Cancer",
        "abstract": "Objective To explore the clinical application of combination of radiolabeled colloid(99Tcm-sulphur colloid)and blue dye in sentinel lymph node biopsy(SLNB)for early-stage breast cancer.Methods SLNB was performed with the guidance of blue dye,radiolabeled colloid,and the combination method in all patients enrolled,and clinical and pathological data were recorded respectively for analysis.Results Two hundred and one patients were enrolled in this study and the SLN were successfully detected in 200 cases.The identification rate of radiolabeled colloid method and combination method was 99.5%(200/201)and 99.5%(198/199)respectively,which significantly higher than blue dye method(85.4%,P < 0.001).There were no differences of accuracy rate\u301495.3%(162/170)vs.94.5%(189/200)vs.98.0%(194/198),P=0.185\u3015and false negative rate\u301411.3%(8/71)vs.13.9%(11/79)vs.5.1%(4/79),P=0.165)between blue dye method,radiolabeled colloid method,and combination method.The combination method could detect more SLN than radiolabeled colloid method or blue dye method only(P < 0.001).Compared to combination method,there were 12 and 7 patients miss diagnosed in blue dye method and radiolabeled colloid method,and the miss diagnosed rate was 16.0%(12/75)and 9.3%(7/75),respectively.Conclusions Compared to radiolabeled colloid and blue dye method,combination method has higher identification rate,and could identify more SLNs.It is recommended that the combination of radiolabeled colloid and blue dye should be adapted for procedure of SLNB in clinical practice.",
        "keywords": [
            "Sentinel lymph node biopsy",
            "Breast cancer",
            "Blue dye",
            "Radiolabeled colloid"
        ],
        "authors": [
            {
                "name": "TIAN Chun-xiang",
                "org": ",LU Qing1. 1. Department of Thyroid & Breast Surgery,West China Hospital,Sichuan University,Chengdu ,Sichuan Province,China"
            },
            {
                "name": "CHEN Jie",
                "org": ",LU Qing1. 1. Department of Thyroid & Breast Surgery,West China Hospital,Sichuan University,Chengdu ,Sichuan Province,China"
            },
            {
                "name": "WEI Bing",
                "org": " Department of Pathology,West China Hospital,Sichuan University,Chengdu ,Sichuan Province,China"
            },
            {
                "name": "OU Xiao-hong",
                "org": " Department of Nuclear Medicine,West China Hospital,Sichuan University,Chengdu ,Sichuan Province,China"
            },
            {
                "name": "ZHANG Zhang",
                "org": " Department of Pathology,West China Hospital,Sichuan University,Chengdu ,Sichuan Province,China"
            },
            {
                "name": "ZHOU Li-na",
                "org": " Department of Nuclear Medicine,West China Hospital,Sichuan University,Chengdu ,Sichuan Province,China"
            },
            {
                "name": "LONG Quan-yi",
                "org": ",LU Qing1. 1. Department of Thyroid & Breast Surgery,West China Hospital,Sichuan University,Chengdu ,Sichuan Province,China"
            },
            {
                "name": "ZENG He-lin",
                "org": ",LU Qing1. 1. Department of Thyroid & Breast Surgery,West China Hospital,Sichuan University,Chengdu ,Sichuan Province,China"
            },
            {
                "name": "WANG Qiang",
                "org": ",LU Qing1. 1. Department of Thyroid & Breast Surgery,West China Hospital,Sichuan University,Chengdu ,Sichuan Province,China"
            },
            {
                "name": "FAN Xue-jiao",
                "org": ",LU Qing1. 1. Department of Thyroid & Breast Surgery,West China Hospital,Sichuan University,Chengdu ,Sichuan Province,China"
            },
            {
                "name": "WANG Rong",
                "org": ",LU Qing1. 1. Department of Thyroid & Breast Surgery,West China Hospital,Sichuan University,Chengdu ,Sichuan Province,China"
            }
        ],
        "venue": "Chinese Journal of Bases and Clinics in General Surgery",
        "year": 2012
    },
    "VvpsgF3O": {
        "id": "VvpsgF3O",
        "title": "High risk factors of the third level of lymphatic metastasis in breast cancer patients received radical/modified mastectomy: an analysis of 746 cases]",
        "abstract": "To study the high risk factors of the third level of lymphatic metastasis in breast cancer patients to guide clinical practice.The clinical data of 746 breast cancer patients (all female, aged from 33 to 80 years with a median of 46 years) received radical or modified mastectomy between 2001 and 2011 was analyzed retrospectively. Eleven individual variables were selected to investigate high risk factors of the third level of lymphatic metastasis in different conditions.Axillary nodes metastasis status (OR = 4.541, 95%CI:3.569-5.776), tumor site (OR = 1.437, 95%CI:1.029-2.007), external nodes involved (OR = 3.809, 95%CI:1.683-8.618) and estrogen receptor (OR = 0.740, 95%CI:0.569-0.964) were high risk factors of the third level of lymphatic metastasis. Further analysis found that it is prone to happen a metastasis, especially when the tumor with a size over 5 cm and located at the lateral quadrant. Negative estrogen receptor was a risk factor of the third level lymphatic metastasis along with the tumor stage.For preoperative tumor biopsy shows Negative estrogen receptor of tumor stage T3 and over stage T3 when considering suspicious lymph node metastasis or external tissues metastasis intraoperatively should take in account into third level axillary lymph node dissection actively.",
        "keywords": [],
        "authors": [
            {
                "name": "Rong Wang",
                "org": "Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Chunxiang Tian",
                "org": "Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Xuejiao Fan",
                "org": "Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Yuehe Fu",
                "org": "Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Jing Wang",
                "org": "Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Hongjiang Li",
                "org": "Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Xiaodong Wang",
                "org": "Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Qing Lyu",
                "org": "Department of Thyroid and Breast Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. Email: lqlq1963@163.com."
            }
        ],
        "venue": "Zhonghua wai ke za zhi [Chinese journal of surgery]",
        "year": 2014
    },
    "LZSrOmBJ": {
        "id": "LZSrOmBJ",
        "title": "A Study on the Effect of Tanshinone \u2161A Against Human Breast Cancer in vivo",
        "abstract": "Objective To confirm Tanshinone \u2161A's(Tan\u2161A) anti-cancer activity on nude mice bearing human breast cancer cells with estrogen receptor(ER) positive and negative and to elucidate the mechanism of its activity in vivo.Methods Established the animal model of nude mices bearing human breast cell,both ER positive MCF-7 and ER negative MDA-MB-231,each group was divided into 3 subgroups,respectively by intraperitoneal injection of Tan\u2161A at a dose of 30 mg/kg 4 times/week,by gavage of Tamoxifen at a dose of 1 mg/kg 7 times/week and by solvent control for 4 weeks.All animals were tested for anti-cancer activity including the weights and the volumes of the tumor,apoptosis index by flow cytometry and expression of p53,bcl-2,cerbB-2 by immunohistochemistry method after the treatment.Results In MCF-7 group,there were a 33.64% tumor mass volume reduction and a 32.24% tumor mass weight reduction after Tan\u2161A treatment;in MDA-MB-231 group,a 38.34% tumor mass volume reduction and a 39.82% tumor mass weight reduction were observed in Tan\u2161A subgroups;the differences between Tan\u2161A and Tamoxifen or solvent control were statistically significant in both groups(P<0.05);Increase of apoptosic fiction by flow cytometry examination in Tan\u2161A subgroups in both MCF-7(48.31%\u00b15.84%) and MDA-MB-231(50.25%\u00b15.03%) groups were observed,there were both significant differences between Tan\u2161A and the other subgroups(P<0.05).Statistically significant decrease of p53 and bcl-2 expression were observed in Tan\u2161A between solvent control subgroup in both MCF-7 and MDA-MB-231 groups(P<0.05) while cerbB-2 had no significant difference with control group(P>0.05).Conclusion Tan\u2161A can inhibit both breast cancer cell MCF-7 and MDA-MB-231 growth in vivo,which had better anti-cancer effect than Tamoxifen.The mechanism may be associated with the induction of apoptosis,down regulation of the expression level of gene bcl-2 and p53,but may not with the expression level of cerbB-2.",
        "keywords": [
            "Tanshinone \u2161A Breast cancer Anti-cancer apoptosis Apoptosis"
        ],
        "authors": [
            {
                "name": "ZHANG Xin",
                "org": ",LU Qing1.1.Department of Thyroid and Breast Surgery,West China Hospital,Sichuan University,Chengdu ,China;Department of Breast Surgery,Sichuan Cancer Hospital,Chengdu ,China"
            },
            {
                "name": "ZHANG Pu-rong",
                "org": "Department of Breast Surgery,Sichuan Cancer Hospital,Chengdu ,China"
            },
            {
                "name": "CHEN Jie",
                "org": ",LU Qing1.1.Department of Thyroid and Breast Surgery,West China Hospital,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Journal of Sichuan University(Medical Science Edition)",
        "year": 2010
    },
    "q5D2gUF1": {
        "id": "q5D2gUF1",
        "title": "Influence Factors of Neoadjuvant Chemotherapy-Related Amenorrhea in Premenopausal Breast Cancer Women and Its Clinical Significance",
        "abstract": "Objective To analyze the influence factors of amenorrhea in premenopausal breast cancer women treated with neoadjuvant chemotherapy and the relationship of neoadjuvant chemotherapy-related amenorrhea(NCRA) to down-staging of tumor.Methods Two hundred and twenty-four premenopausal breast cancer patients undergoing neoadjuvant chemotherapy from March 2006 to March 2011 in this hospital were investigated retrospectively.The effects of age,chemotherapy regiment,ER/PR status,Her-2 status,and tamoxifen(TAM)on NCRA and recovery of menstruation were assessed.The average age of the patients who had accepted different chemotherapy cycles when NCRA occurred was described,and the effect of different chemotherapy cycles on recovery of menstruation was evaluated.Tumor volume change was estimated to analysis the relation between NCRA and tumor response to chemotherapy.Results One hundred and sixty-six(74.11%)cases occurred NCRA,40(26.49%)cases returned to normal menstruation apart from 15 cases who had accepted oophorectomy or the luteinizing hormone-releasing hormone analog goserelin before menstrual status change.The results of univariate analysis and multivariate analysis indicated that the NCRA and menstruation recovery were both related to age at diagnosis(P<0.001,P=0.001),and only menstruation recovery was related to chemotherapy regiments(P<0.001).However,the NCRA and menstruation recovery were not related to ER/PR status,Her-2 status,and TAM(P>0.05).Chemotherapy cycles when NCRA occurred decreased with the increase of age,and wasn\u2019t associated with menstruation recovery(P >0.05).There was no correlation between NCRA and downstage of tumor after neoadjuvant chemotherapy(P>0.05).Conclusions Amenorrhea resulted from neoadjuvant chemotherapy in most of breast cancer patients,which occurs more commonly in elder ones with less chemotherapy cycles.Quite a few patients resume menses after NCRA,which is associated with age and chemotherapy regiments.NCRA doesn\u2019t influence tumor response to chemotherapy.",
        "keywords": [
            "Neoadjuvant chemotherapy",
            "Amenorrhea",
            "Breast cancer",
            "Periodicity"
        ],
        "authors": [
            {
                "name": "FAN Xue-jiao",
                "org": ",LU Qing.Department of Thyroid and Breast Surgery,West China Hospital,Sichuan University,Chengdu ,Sichuan Province,China"
            },
            {
                "name": "WANG Rong",
                "org": ",LU Qing.Department of Thyroid and Breast Surgery,West China Hospital,Sichuan University,Chengdu ,Sichuan Province,China"
            },
            {
                "name": "CHEN Jie",
                "org": ",LU Qing.Department of Thyroid and Breast Surgery,West China Hospital,Sichuan University,Chengdu ,Sichuan Province,China"
            },
            {
                "name": "TIAN Chun-xiang",
                "org": ",LU Qing.Department of Thyroid and Breast Surgery,West China Hospital,Sichuan University,Chengdu ,Sichuan Province,China"
            },
            {
                "name": "ZENG He-lin",
                "org": ",LU Qing.Department of Thyroid and Breast Surgery,West China Hospital,Sichuan University,Chengdu ,Sichuan Province,China"
            }
        ],
        "venue": "Chinese Journal of Bases and Clinics in General Surgery",
        "year": 2013
    },
    "uIfhxs7s": {
        "id": "uIfhxs7s",
        "title": "Randomized Controlled Research on the Use of Harmonic Scalpel during Modified Radical Mastectomy for Patients with Breast Cancer",
        "abstract": "Objective To compare the disadvantages and advantages between modified radical mastectomy with harmonic scalpel(HS) and conventional electro-scalpel(ES) for patients with breast cancer.Methods Between June 2009 and July 2010,176 patients with breast cancer were randomly divided into two groups including the HS group and the ES group.The operation time,intra-operative bleeding volume,the number of lymph nodes detected,postoperative drainage volume,subcutaneous hydrops,and postoperative hemorrhage volume between the two groups of patients were compared.Results There were significant differences between the HS and ES groups in terms of operation time [(145.72\u00b150.76) minutes vs.(171.27\u00b166.68) minutes,P=0.005],intra-operative bleeding volume [(71.56\u00b131.34) mL vs.(84.99\u00b136.39) mL,P=0.009],and number of lymph nodes detected(20.92\u00b19.09 vs.17.90\u00b16.74,P<0.05).The postoperative drainage volume and subcutaneous hydrops were not significantly different between the two groups(P>0.05).No postoperative hemorrhage occurred in both groups.Conclusion Compared with ES,the use of HS can reduce operation time and intra-operative bleeding volume,and increase the number of lymph nodes detected during modified radical mastectomy.",
        "keywords": [
            "Modified radical mastectomy",
            "Harmonic scalpel",
            "Breast cancer"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": ".Department of Thyroid and Breast Surgery,West China Hospital of Sichuan University,Chengdu,Sichuan ,P.R.China"
            },
            {
                "name": "ZENG He-lin",
                "org": ".Department of Thyroid and Breast Surgery,West China Hospital of Sichuan University,Chengdu,Sichuan ,P.R.China"
            },
            {
                "name": "L\u00fc Qing",
                "org": ".Department of Thyroid and Breast Surgery,West China Hospital of Sichuan University,Chengdu,Sichuan ,P.R.China"
            },
            {
                "name": "TIAN Chun-xiang",
                "org": ".Department of Thyroid and Breast Surgery,West China Hospital of Sichuan University,Chengdu,Sichuan ,P.R.China"
            },
            {
                "name": "GOU Ju-xiang",
                "org": ".Department of Thyroid and Breast Surgery,West China Hospital of Sichuan University,Chengdu,Sichuan ,P.R.China"
            }
        ],
        "venue": "West China Medical Journal",
        "year": 2011
    },
    "b2HwYSUp": {
        "id": "b2HwYSUp",
        "title": "Construction and identification of recombinant adenovirus vector containing siRNA for rat TLR2 gene]",
        "abstract": "To construct the recombinant adenovirus vector containing specific small interfering RNA (siRNA) targeting rat TLR2 gene and identify its function in PC12 cells.Three pairs of double-stranded DNA fragments for silencing rat TLR2 were annealed in vitro, then directional cloned into the pSES-HUS vector to construct pSES-HUS-siTLR2 plasmid. Afterward, the correct recombinant was linearized by PmeI, following co-transformation with the backbone vector pAdEasy-1 in E.coli BJ5183 to construct pAd-siTLR2 plasmid, and then transfected into HEK293 cell line via Lipofectamine to package the adenovirus. PC12 cells were infected with the adenovirus Ad-siTLR2, and inhibition of siRNA was detected with Real-time PCR and Western blotting.Using plasmid PCR and gene sequencing, the siTLR2 target gene was verified to be correctly cloned in the adenovirus vector. Trough Real-time PCR and Western blotting, TLR2 expression was significantly decreased in the PC12 cells which was infected with the adenovirus Ad-siTLR2.Successfully constructed the recombinant adenovirus vector containing rat siTLR2 gene and packaged the adenovirus in HEK293 cell line, which could effectively reduce TLR2 expression in the PC12 cells to facilitate the study of the immunoregulation mechanisms of TLR2 in different diseases.",
        "keywords": [
            "sirna",
            "recombinant adenovirus vector",
            "immunoregulation",
            "tlr2"
        ],
        "authors": [
            {
                "name": "Yun Zhang",
                "org": " Children' s Nutrition Research Center,Key Laboratory of Developmental Diseases in Childhood of Ministry of Education,Key Laboratory of Pediatrics in Chongqing,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder.Children' s Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "Min Gong",
                "org": " Children' s Nutrition Research Center,Key Laboratory of Developmental Diseases in Childhood of Ministry of Education,Key Laboratory of Pediatrics in Chongqing,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder.Children' s Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "Yang Bi",
                "org": " Children' s Nutrition Research Center,Key Laboratory of Developmental Diseases in Childhood of Ministry of Education,Key Laboratory of Pediatrics in Chongqing,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder.Children' s Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "Wei Jiang",
                "org": " Children' s Nutrition Research Center,Key Laboratory of Developmental Diseases in Childhood of Ministry of Education,Key Laboratory of Pediatrics in Chongqing,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder.Children' s Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "Qin Yu",
                "org": " Children' s Nutrition Research Center,Key Laboratory of Developmental Diseases in Childhood of Ministry of Education,Key Laboratory of Pediatrics in Chongqing,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder.Children' s Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "Ting-yu Li",
                "org": " Children' s Nutrition Research Center,Key Laboratory of Developmental Diseases in Childhood of Ministry of Education,Key Laboratory of Pediatrics in Chongqing,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder.Children' s Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "Jie Chen",
                "org": " Children' s Nutrition Research Center,Key Laboratory of Developmental Diseases in Childhood of Ministry of Education,Key Laboratory of Pediatrics in Chongqing,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder.Children' s Hospital of Chongqing Medical University,Chongqing ,China"
            }
        ],
        "venue": "Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology",
        "year": 2012
    },
    "yWFxdYte": {
        "id": "yWFxdYte",
        "title": "Gestational vitamin A deficiency reduces the intestinal immune response by decreasing the number of immune cells in rat offspring.",
        "abstract": "Vitamin A (VA) is a critical micronutrient for life, especially during growth and development. There is a close relationship between VA deficiency (VAD) and the morbidity of diarrhea in the clinical setting. However, the regulatory mechanisms of VA are not clearly understood.Specific-pathogen-free Wistar rats received a diet with or without VA before gestation. The offspring were submitted to an abdominal injection of Escherichia coli lipopolysaccharide. After the challenge, which lasted for 12 h, the serum retinol was detected by high-performance liquid chromatography, and the level of immunoglobulin A in the stool was analyzed by enzyme-linked immunosorbent assay. The lymphocyte immunophenotypes were evaluated with the use of flow cytometry with samples collected from the spleen, the mesenteric lymph nodes, Peyer patches, and intestinal intraepithelial lymphocytes.Early life VAD, independent of the lipopolysaccharide challenge, significantly decreased serum retinol level and CD8(+) intestinal intraepithelial lymphocytes. The level of immunoglobulin A secretion and percentages of splenic CD4(+)CD8(+) T cells were affected by the interaction effects of the lipopolysaccharide challenge and VAD treatment. Gestational VAD significantly increased the percentages of B cells in the mesenteric lymph nodes and decreased the percentages of CD11 C(+) dendritic cells and CD4(+)CD25(+) T cells from the Peyer patches. The lipopolysaccharide challenge only significantly increased percentages of splenic CD4(+)CD25(+) T cells. The intestinal tissue of the pups with VAD displayed mild inflammation.Gestational or early life VAD decreases the numbers of immune cells in offspring, which may partly suppress the activities of the mucosal immune responses in the intestine. This suggests that more attention should be given to the VA nutritional state of children and women of reproductive age.",
        "keywords": [
            "early life period",
            "gestation",
            "lipopolysaccharides",
            "lymphocytes",
            "vitamin a deficiency"
        ],
        "authors": [
            {
                "name": "Xia Liu",
                "org": "Children Nutrition Research Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, CSTC2009 CA5002, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, P.R. China."
            },
            {
                "name": "Yingying Li",
                "org": "Children Nutrition Research Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, CSTC2009 CA5002, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, P.R. China."
            },
            {
                "name": "Yuting Wang",
                "org": "Children Nutrition Research Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, CSTC2009 CA5002, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, P.R. China."
            },
            {
                "name": "Qinghong Wang",
                "org": "Institute of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, P.R. China."
            },
            {
                "name": "Xin Li",
                "org": "Institute of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing, P.R. China."
            },
            {
                "name": "Yang Bi",
                "org": "Children Nutrition Research Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, CSTC2009 CA5002, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, P.R. China."
            },
            {
                "name": "Lan Liu",
                "org": "Laboratory of Intestinal Physiology and Pathology, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA."
            },
            {
                "name": "Xiaoping Wei",
                "org": "Children Nutrition Research Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, CSTC2009 CA5002, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, P.R. China."
            },
            {
                "name": "Tingyu Li",
                "org": "Children Nutrition Research Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, CSTC2009 CA5002, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, P.R. China."
            },
            {
                "name": "Jie Chen",
                "org": "Children Nutrition Research Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, CSTC2009 CA5002, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, P.R. China."
            }
        ],
        "venue": "Nutrition (Burbank, Los Angeles County, Calif.)",
        "year": 2014
    },
    "PGbwlM6j": {
        "id": "PGbwlM6j",
        "title": "Correlation between vitamin A and erythropoietin levels in preschool children of Banan district of Chongqing",
        "abstract": "Objective To study the correlation of vitamin A (VA) with hemoglobin (Hb) and erythropoietin (EPO) levels in preschool children of Banan district of Chongqing,and the mechanism underlying the correlation between VA deficiency and anemia.Methods A total of 349 preschool children meeting the inclusion criteria were randomly recruited from 3 kindergartens in Banan district of Chongqing.Serum VA,EPO,and Hb levels were measured by high-performance liquid chromatography (HPLC),chemiluminescent immunoassay,and cyanmethemoglobin determination method,respectively,and their correlation was analyzed.Results The rate of VA deficiency,suspicious sub-clinical VA deficiency and anemia was 1.72%,22.64%,and 22.64%,respectively,in preschool children of Banan district of Chongqing (P<0.05).The incidence of anemia was 2.32-fold higher in children with a lower VA level than in those with a normal VA level.The EPO level was significantly higher in children with anemia than in those without anemia (P<0.05).The Hb level was negatively correlated with the EPO level in children with anemia (r=-0.46,P<0.05).Log10 regression equation showed that the slope of VA increased by 0.000 2 compared with normal VA.Conclusion VA level can influence the feedback regulatory effect of Hb on EPO level.",
        "keywords": [
            "preschool children",
            "anemia",
            "erythropoietin",
            "vitamin a",
            "hemoglobin"
        ],
        "authors": [
            {
                "name": "Liu Yongfang",
                "org": "Nutritional Research Center,Children\u2019s Hospital,Chongqing Medical University,Chongqing,;College of Public Health,Chongqing Medical University,Chongqing,,China"
            },
            {
                "name": "Gong Min",
                "org": "Nutritional Research Center,Children\u2019s Hospital,Chongqing Medical University,Chongqing,"
            },
            {
                "name": "Chen Li",
                "org": "Nutritional Research Center,Children\u2019s Hospital,Chongqing Medical University,Chongqing,"
            },
            {
                "name": "Jiang Wei",
                "org": "Nutritional Research Center,Children\u2019s Hospital,Chongqing Medical University,Chongqing,"
            },
            {
                "name": "Liu Youxue",
                "org": "Nutritional Research Center,Children\u2019s Hospital,Chongqing Medical University,Chongqing,"
            },
            {
                "name": "Chen Jie",
                "org": "Nutritional Research Center,Children\u2019s Hospital,Chongqing Medical University,Chongqing,"
            },
            {
                "name": "Qu Ping",
                "org": "Nutritional Research Center,Children\u2019s Hospital,Chongqing Medical University,Chongqing,"
            },
            {
                "name": "Li Tingyu",
                "org": "Nutritional Research Center,Children\u2019s Hospital,Chongqing Medical University,Chongqing,"
            }
        ],
        "venue": "Acta Academiae Medicinae Militaris Tertiae",
        "year": 2010
    },
    "xsen7WQ8": {
        "id": "xsen7WQ8",
        "title": "The effect of hypertension and diabetes management in Southwest China: a before- and after-intervention study.",
        "abstract": "Non-communicable diseases are leading causes of disease burden in middle income countries. Little evidence exists to determine if the primary healthcare system can effectively manage non-communicable diseases. The purpose of this study was to examine the effectiveness of hypertension and diabetes management by the primary healthcare system.We used individual level data from the 2009 National Basic Public Health Services System to assess the effectiveness of hypertension and diabetes interventions on fasting plasma glucose, and blood pressure. We analyzed the associations between fasting plasma glucose, systolic or diastolic blood pressure and risk factors. The estimated average intervention effect on data balanced with confounding variables was assessed.9543 individuals who had data for fasting plasma glucose, systolic blood pressure and diastolic blood pressure were included in this analysis. This study included 6681 patients with hypertension and 2222 with diabetes. The intervention lowered mean fasting plasma glucose by 0.5 mmol/L (0.4-0.6), lowered mean systolic blood pressure by 3.5 mm Hg (3.2-3.7), and lowered diastolic blood pressure by 2.9 mm Hg (2.7-3.2). Individuals who received medicinal treatment had 1.3 mmHg (0.8 to 1.8, P<0.01) lower diastolic blood pressure and 0.6 mmol/L (0.5-0.8, P<0.01) lower fasting plasma glucose than those who did not receive medicine. Generalized linear model indicated that medicinal treatment and baseline systolic blood pressure were significant positive predictors of change in systolic blood pressure. Age, living in urban areas and diabetic complications were significant negative predictors of change for systolic blood pressure.The National Basic Public Health Services System in China using trained community healthcare workers and well-established guidelines can be effectively implement non-communicable disease prevention and management care paradigms.",
        "keywords": [
            "blood pressure",
            "china",
            "young adult",
            "diabetes mellitus"
        ],
        "authors": [
            {
                "name": "Xiaohua Liang",
                "org": "Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital, Chongqing Medical University, Chongqing, People's Republic of China; Centers for Disease Control and Prevention of Jiulongpo District, Chongqing, People's Republic of China."
            },
            {
                "name": "Jie Chen",
                "org": "Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital, Chongqing Medical University, Chongqing, People's Republic of China."
            },
            {
                "name": "Youxue Liu",
                "org": "Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital, Chongqing Medical University, Chongqing, People's Republic of China."
            },
            {
                "name": "Chunling He",
                "org": "Centers for Disease Control and Prevention of Jiulongpo District, Chongqing, People's Republic of China."
            },
            {
                "name": "Tingyu Li",
                "org": "Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital, Chongqing Medical University, Chongqing, People's Republic of China."
            }
        ],
        "venue": "PloS one",
        "year": 2014
    },
    "Y1fQQSBB": {
        "id": "Y1fQQSBB",
        "title": "Inhibition of mircoRNA-34a Enhances Survival of Human Bone Marrow Mesenchymal Stromal/Stem Cells Under Oxidative Stress.",
        "abstract": "BACKGROUND Mesenchymal stromal/stem cells (MSCs) are broadly used for many diseases, but the efficacy of MSC engraftment is very low due to low viability and high cell death rate under a stressful microenvironment. The present study aimed to investigate whether microRNA-34a (miR-34a), which is a downstream target of P53, is involved in H2O2-induced MSC cell death. MATERIAL AND METHODS Human bone marrow MSCs (hMSCs) were purchased from Lonza and were cultured as previously described. hMSCs were transfected with miR-34a inhibitor and exposed to H2O2. Cell proliferation assay was used to assess the survival rate of hMSCs. Real-time PCR and Western blot analysis were used to examine proliferation and survival ability of hMSCs. RESULTS H2O2 exposure significantly increased miR-34a expression in human bone marrow MSCs. H2O2 challenge induced massive MSC cell death along with reduction of expression of proliferation marker Ki67 and survival-related genes Bcl-2 and Survivin. Transfection of miR-34a inhibitor anti-34a led to a significant protective effect and rescued MSC cell death triggered by H2O2 exposure by 50%. Moreover, anti-34a dramatically increased Bcl-2 and Ki67 mRNA expression levels by over 10-fold compared to the mock control group under H2O2 exposure. The protein levels of Bcl-2 and Survivin were also rescued by anti-34a treatment by 50%. CONCLUSIONS Our results suggest that miR-34a plays a key role in oxidative stress-induced MSC cell death, and targeting miR-34a might be a promising strategy to enhance the survival rate of engrafted stem cells, which may improve therapeutic outcome.",
        "keywords": "",
        "authors": [
            {
                "name": "Yang Liu",
                "org": "Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China (mainland)."
            },
            {
                "name": "Xiaohu Zhang",
                "org": "Sichuan University - The Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China (mainland)."
            },
            {
                "name": "Jie Chen",
                "org": "Children's Hospital of Chongqing Medical University, Chongqing, China (mainland)."
            },
            {
                "name": "Tingyu Li",
                "org": "Children's Hospital of Chongqing Medical University, Chongqing, China (mainland)."
            }
        ],
        "venue": "Medical science monitor : international medical journal of experimental and clinical research",
        "year": 2018
    },
    "uNT6nEuT": {
        "id": "uNT6nEuT",
        "title": "A cross-section investigation of infant feeding following the latest WHO infant feeding recommendation",
        "abstract": "Objective Adequate nutrition during infancy is fundamental to the development of each child's full human potential.It is well recognized that the period from birth to one year of age is a 'critical window' for the promotion of optimal growth,health and behavioral development.Many infant feeding recommendations were issued by WHO in the past decade.The current study aims at investigating feeding practices following the latest infant feeding recommendation issued by WHO in 2002.Methods A cross-section investigation was conducted in the department of primary child care,Children's Hospital of Chongqing Medical University,which was located in southwest of China,from June 2008 to May 2009.Total 978 healthy infants who were recieving regular physical examination in the hospital were recruited unrandomly,including 529/976(54.2%) boys and 447/976(45.8%) girls,aged 2 months(n=7),3 months(n=45),4 months(n=124),5 months(n=233),6 months(n=283),7 months(n=107),8 months(n=86),9 months(n=45),10 months(n=30),11months(n=10),12 months(n=8),respectively.A questionnaire was used to collect information of infants' data and feeding practice which was assessed by 24-hours recall from their major dependents.The anthropometric data of infants including weight and length were measured by qualified nurses using standard instruments and following standard protocol.Weight-for-length Z-score(WLZ),weight-for-age Z-score(WAZ) and length-for-age Z-score(LAZ) were calculated with Anthro software(version 3,April 2009).Means of weight,length,WLZ,WAZ and LAZ at different ages were compared with WHO growth standards using t tests.Results There was a considerable variety of feeding practices compared with the latest infant feeding recommendation issued by WHO.About 89.8% infants were breastfed,of whom 41.5% of whom were exclusively breastfed after delivery,however,10.2% of the infants had never been breastfed.The proportion of breastfed infants was 25/45(55.6%) at 3 months,53/124(42.7%) at 4 months,114/233(48.9%) at 5 months and 100/283(35.3%)at 6 months,respectively.The proportion of exclusively breastfed infants was 15/45(33.3%) at 3 months,27/124(21.8%) at 4 months,23/233(11.2%) at 5 months,respectively.By the age of 6 months,the rate of exclusive breastfeeding was dramatically decreased to 15/283(5.3%).It did not meet the standard of exclusive breastfeeding for 6 months(180 days) recommended by WHO.The time of introducing complementary food varied,with 8.8% of infants being introduced complementary foods before 4 months,and the percentage increased to 66.0% during 4-5 months,12.3% after 6 months,respectively.First food introduced to infancy was infant rice powder(65.5%),yolk(17.2%),vegetable or fruit(9.3%),homemade rice(7.4%) or fish(0.6%),respectively.The median age of introducing infant rice powder,gruels,yolk,vegetable,fruit,meat,fish,rice,noodle and bean was 4.5,5.7,5.2,5.1,5.1,6.7,6.8,7.9,6.6 and 7.0 months.Physical growth of the group of infants was above the WHO reference regardless of the time of complementary feeding during 2-12 months of age.Both infants' weights reached up to the average level of WHO growth curve 2005(P>0.05),whether or not exclusive breastfeeding was taken during 4-6 months.Mean and standard deviation of WLZ was 0.7\u00b11.1,0.7\u00b10.9,0.6\u00b10.9,0.6\u00b10.9,0.7\u00b11.0,0.6\u00b10.9,0.6\u00b10.8,0.4\u00b10.8,0.6\u00b11.0,1.0\u00b10.6 that differred significantly from zero(P<0.05) during 3-11 months,respectively.There was no difference found in WLZ,WAZ,and LAZ among the different feeding practice groups at 4th-6th month.Conclusions The current study indicated a unsatisfactory compliancy to WHO recommendation in infant feeding.Compared with WHO recommendation,the study sample showed lower pure breastfeeding rate,but higher proportion of formular feeding in the first 6 months.However,there was few significant difference in growth status associated with early infant feeding practice during the first year in our study.",
        "keywords": [
            "Breastfeeding",
            "Physical growth",
            "Complementary feeding",
            "Infants"
        ],
        "authors": [
            {
                "name": "KANG Yu",
                "org": " Department of Nutrition and Food Hygiene,School of Public Health,Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "LI Ting-yu",
                "org": " Department of Children's Nutrition,Children's Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "HU Yan",
                "org": " Department of Primary Child Care,Children's Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "CHENG Qian",
                "org": " Department of Primary Child Care,Children's Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "LIU You-xue",
                "org": " Department of Children's Nutrition,Children's Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": " Department of Children's Nutrition,Children's Hospital of Chongqing Medical University,Chongqing ,China"
            }
        ],
        "venue": "Chinese Journal of Evidence-Based Pediatrics",
        "year": 2010
    },
    "wjSfu7Jt": {
        "id": "wjSfu7Jt",
        "title": "Effect of all-trans retinoic acid and 9-cis-RA on apoptosis of PC12 cells after oxygen and glucose-deprivation injury",
        "abstract": "Objective To investigate the effect of different retinoic acid(RA) configurations,all-trans retinoic acid(ATRA) and 9-cis-RA on apoptosis of PC12 cells after oxygen and glucose-deprivation(OGD) injury,and explore the receptor pathway involved in.Methods Cell morphology before and after OGD injury was observed with inverted microscopy,and the apoptotic rate of PC12 cells treated with different concentrations of ATRA and 9-Cis-RA was studied by flow cytometr after OGD injuryy.Finally,LDH release from PC12 cells was measured by ELISA after 4 hours' RA treatment for degree of membrane damage.There were 9 groups: A(0 \u03bcmol/L RA);B(1 \u03bcmol/L ATRA);C(1 \u03bcmol/L 9-CisRA);D(5 \u03bcmol/L ATRA);E(5 \u03bcmol/L 9-CisRA);F(10 \u03bcmol/L ATRA);G(10 \u03bcmol/L 9-CisRA);H(20 \u03bcmol/L ATRA);I(20 \u03bcmol/L 9-CisRA).Results ATRA at a dose of 1 \u03bcmol/L had no effect on the apoptosis of PC12 cells after OGD injury,as the cells without RA treatment(P>0.05).But the apoptotic rate were significant increasing when the concentration of ATRA was elevated from 5 \u03bcmol/L to 20 \u03bcmol/L(P<0.05).The apoptotic rates in 10 and 20 \u03bcmol/L groups were significantly higher than those of the 9-Cis-RA groups with same stimulus concentration(P<0.05) and 0 \u03bcmol/L group(P<0.05).However,the apoptotic rate in 20 \u03bcmol/L 9-Cis-RA was lower than that of 0 \u03bcmol/L group(P>0.05),but was not significantly.The levels of LDH release of ATRA stimulation groups were significantly increasing from 5 \u03bcmol/L with the concentration rising(P<0.01),and were significantly higher than that of control and 9-Cis-RA stimulation groups(P<0.05).There was no significant difference in LDH release between 0 \u03bcmol/L group,and each 9-Cis-RA group(P>0.05).Conclusion ATRA improves the apoptosis of PC12 cells after OGD injury through activating retinoic acid receptors(RAR),while this effect might be inhibited by 9-Cis-RA via retinoid X receptors(RXRs).",
        "keywords": [
            "retinoic acid receptor",
            "apoptosis",
            "9-cis-retinoic acid",
            "all-trans retinoic acid",
            "oxygen and glucose-deprivation",
            "PC12 cell",
            "retinoic acid X receptor"
        ],
        "authors": [
            {
                "name": "Jiang Wei",
                "org": "1Nutritional Research Center,Key Laboratory of Children's Development Diseases of Chongqing and Ministry of Education,Children's Hospital,Chongqing Medical University,Chongqing,,2Department of Pediatrics,Xinqiao Hospital,Third Military Medical University,Chongqing,,China"
            },
            {
                "name": "Wen Enyi",
                "org": "1Nutritional Research Center,Key Laboratory of Children's Development Diseases of Chongqing and Ministry of Education,Children's Hospital,Chongqing Medical University,Chongqing,,2Department of Pediatrics,Xinqiao Hospital,Third Military Medical University,Chongqing,,China"
            },
            {
                "name": "Gong Min",
                "org": "1Nutritional Research Center,Key Laboratory of Children's Development Diseases of Chongqing and Ministry of Education,Children's Hospital,Chongqing Medical University,Chongqing,,2Department of Pediatrics,Xinqiao Hospital,Third Military Medical University,Chongqing,,China"
            },
            {
                "name": "Qu P",
                "org": "1Nutritional Research Center,Key Laboratory of Children's Development Diseases of Chongqing and Ministry of Education,Children's Hospital,Chongqing Medical University,Chongqing,,2Department of Pediatrics,Xinqiao Hospital,Third Military Medical University,Chongqing,,China"
            },
            {
                "name": "Bi Yang",
                "org": "1Nutritional Research Center,Key Laboratory of Children's Development Diseases of Chongqing and Ministry of Education,Children's Hospital,Chongqing Medical University,Chongqing,,2Department of Pediatrics,Xinqiao Hospital,Third Military Medical University,Chongqing,,China"
            },
            {
                "name": "Zhang Yun",
                "org": "1Nutritional Research Center,Key Laboratory of Children's Development Diseases of Chongqing and Ministry of Education,Children's Hospital,Chongqing Medical University,Chongqing,,2Department of Pediatrics,Xinqiao Hospital,Third Military Medical University,Chongqing,,China"
            },
            {
                "name": "Wei Xiaoping",
                "org": "1Nutritional Research Center,Key Laboratory of Children's Development Diseases of Chongqing and Ministry of Education,Children's Hospital,Chongqing Medical University,Chongqing,,2Department of Pediatrics,Xinqiao Hospital,Third Military Medical University,Chongqing,,China"
            },
            {
                "name": "Liu Youxue",
                "org": "1Nutritional Research Center,Key Laboratory of Children's Development Diseases of Chongqing and Ministry of Education,Children's Hospital,Chongqing Medical University,Chongqing,,2Department of Pediatrics,Xinqiao Hospital,Third Military Medical University,Chongqing,,China"
            },
            {
                "name": "Chen Jie",
                "org": "1Nutritional Research Center,Key Laboratory of Children's Development Diseases of Chongqing and Ministry of Education,Children's Hospital,Chongqing Medical University,Chongqing,,2Department of Pediatrics,Xinqiao Hospital,Third Military Medical University,Chongqing,,China"
            },
            {
                "name": "Li Tingyu",
                "org": "1Nutritional Research Center,Key Laboratory of Children's Development Diseases of Chongqing and Ministry of Education,Children's Hospital,Chongqing Medical University,Chongqing,,2Department of Pediatrics,Xinqiao Hospital,Third Military Medical University,Chongqing,,China"
            }
        ],
        "venue": "Acta Academiae Medicinae Militaris Tertiae",
        "year": 2010
    },
    "6NTP6A1b": {
        "id": "6NTP6A1b",
        "title": "Primary culture of rat hippocampal neurons and detection of the neuronal excitability]",
        "abstract": "To improve the efficiency of primary culture of hippocampal neurons and obtain highly purified neurons with good in vitro growth and minimal risk of contamination.The hippocampal neurons of neonatal Wistar rats were isolated and the single cell suspension was prepared by mechanical trituration and sedimentation in stead of trypsin digestion and filteration. Twenty-four hours after the cell plating, the culture medium was removed and replaced by serum-free DMEM/F12 with B27 supplementation. Half of the culture medium was changed 2-3 times every week. The morphological changes of the neurons were observed under inverted phase-contrast microscope. Immunofluorescence staining for NSE was performed to identify the neurons, and the purity of neurons was calculated. The hippocampal neurons were stained with calcium-sensitive fluorescent dye to monitor the effect of KCl on neuronal excitability by a calcium imaging system.This simplified method is time-saving and cost-effective for primary culture of hippocampal neurons with reduced risk of contamination, and the neurons obtained showed high uniformity, purity and long-term viability.",
        "keywords": [
            "immuno histochemistry",
            "cerebral cortex hippocampal neurons",
            "primary culture",
            "calcium imaging"
        ],
        "authors": [
            {
                "name": "Xiao-juan Zhang",
                "org": " Nutrition Research Center,Children's Hospital,Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "Ting-yu Li",
                "org": " Nutrition Research Center,Children's Hospital,Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "You-xue Liu",
                "org": " Nutrition Research Center,Children's Hospital,Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "Jie Chen",
                "org": " Nutrition Research Center,Children's Hospital,Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "Ping Qu",
                "org": " Nutrition Research Center,Children's Hospital,Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "Xiao-ping Wei",
                "org": " Nutrition Research Center,Children's Hospital,Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "Jian He",
                "org": " Nutrition Research Center,Children's Hospital,Chongqing Medical University,Chongqing ,China"
            }
        ],
        "venue": "Nan fang yi ke da xue xue bao = Journal of Southern Medical University",
        "year": 2010
    },
    "vWRCHpOn": {
        "id": "vWRCHpOn",
        "title": "Vitamin A supplementation in early life enhances the intestinal immune response of rats with gestational vitamin A deficiency by increasing the number of immune cells.",
        "abstract": "Vitamin A is a critical micronutrient for regulating immunity in many organisms. Our previous study demonstrated that gestational or early-life vitamin A deficiency decreases the number of immune cells in offspring. The present study aims to test whether vitamin A supplementation can restore lymphocyte pools in vitamin A-deficient rats and thereby improve the function of their intestinal mucosa; furthermore, the study aimed to identify the best time frame for vitamin A supplementation. Vitamin A-deficient pregnant rats or their offspring were administered a low-dose of vitamin A daily for 7 days starting on gestational day 14 or postnatal day 1, day 14 or day 28. Serum retinol concentrations increased significantly in all four groups that received vitamin A supplementation, as determined by high-performance liquid chromatography. The intestinal levels of secretory immunoglobulin A and polymeric immunoglobulin receptor increased significantly with lipopolysaccharide challenge in the rats that received vitamin A supplementation starting on postnatal day 1. The rats in this group had higher numbers of CD8+ intestinal intraepithelial lymphocytes, CD11C+ dendritic cells in the Peyer's patches and CD4+CD25+ T cells in the spleen compared with the vitamin A-deficient rats; flow cytometric analysis also demonstrated that vitamin A supplementation decreased the number of B cells in the mesenteric lymph nodes. Additionally, vitamin A supplementation during late gestation increased the numbers of CD8+ intestinal intraepithelial lymphocytes and decreased the numbers of B lymphocytes in the mesenteric lymph nodes. However, no significant differences in lymphocyte levels were found between the rats in the other two vitamin A supplement groups and the vitamin A-deficient group. In conclusion, the best recovery of a subset of lymphocytes in the offspring of gestational vitamin A-deficient rats and the greatest improvement in the intestinal mucosal immune response are achieved when vitamin A supplementation occurs during the early postnatal period.",
        "keywords": [
            "bioinformatics",
            "biomedical research"
        ],
        "authors": [
            {
                "name": "Xia Liu",
                "org": "Children's Nutrition Research Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, CSTC2009 CA5002, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China."
            },
            {
                "name": "Ting Cui",
                "org": "Children's Nutrition Research Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, CSTC2009 CA5002, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China."
            },
            {
                "name": "Yingying Li",
                "org": "Children's Nutrition Research Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, CSTC2009 CA5002, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China."
            },
            {
                "name": "Yuting Wang",
                "org": "Children's Nutrition Research Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, CSTC2009 CA5002, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China."
            },
            {
                "name": "Qinghong Wang",
                "org": "Institute of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China."
            },
            {
                "name": "Xin Li",
                "org": "Institute of Pediatrics, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China."
            },
            {
                "name": "Yang Bi",
                "org": "Children's Nutrition Research Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, CSTC2009 CA5002, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China."
            },
            {
                "name": "Xiaoping Wei",
                "org": "Children's Nutrition Research Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, CSTC2009 CA5002, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China."
            },
            {
                "name": "Lan Liu",
                "org": "Laboratory of Intestinal Physiology and Pathology, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, United States of America."
            },
            {
                "name": "Tingyu Li",
                "org": "Children's Nutrition Research Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, CSTC2009 CA5002, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China."
            },
            {
                "name": "Jie Chen",
                "org": "Children's Nutrition Research Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, CSTC2009 CA5002, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China."
            }
        ],
        "venue": "PloS one",
        "year": 2014
    },
    "1kJ5MeLg": {
        "id": "1kJ5MeLg",
        "title": "Impact of antioxidant vitamins and heavy metal levels at birth on neurodevelopment of children assessed at two years of age]",
        "abstract": "Epidemiologic study on the perinatal interaction of antioxidant vitamins and heavy metals on offspring's intellectual development is extremely limited. The aim of this prospective cohort study was to investigate the status of maternal and cord blood antioxidant vitamins (Vitamin A, E and C) and heavy metals (lead, cadmium and mercury) at delivery and correlations between these antioxidant vitamins or metals and neurodevelopment of early childhood, and to explore the protective effect of antioxidant vitamins against the injure of heavy metals to intellectual development in children in Tongliang, Chongqing, China.A total of 150 pairs of mothers-neonates were recruited. Serum concentrations of vitamin(V) A, vitamin E, vitamin C, lead, cadmium and mercury in maternal and cord blood after delivery were determined and intellectual development was evaluated by Gesell Development Schedule (GDS) at two years of age.A total of 111 pairs of maternal-neonatal subjects with completed data were included into statistical analysis. After adjusting for potential confounders, cord blood mercury level was found negatively associated with all the development quotients (DQs) (\u03b2 = -0.486, \u03b2 = -0.716, \u03b2 = -0.846, \u03b2 = -0.935, \u03b2 = -0.702, P < 0.05). Cord VE level was positively correlated with motor, adaptation, language and average DQ (\u03b2 = 0.475, \u03b2 = 0.458, \u03b2 = 0.403, \u03b2 = 0.395, P < 0.05). When antioxidant vitamins and heavy metals levels were all included into the multiple regression model, cord vitamin E level was statistically positively related with motor, adaptation and average DQs (\u03b2 = 0.449, \u03b2 = 0.412, \u03b2 = 0.349, P < 0.05). While cord blood mercury level was negatively correlated with adaptation, language, social and average DQ (\u03b2 = -0.397, \u03b2 = -0.727, \u03b2 = -0.935, \u03b2 = -0.628, P < 0.05), the relationship between cord mercury level and motor DQ was not statistically significant (P = 0.0890). The motor, adaptation, language and average DQs in high cord VE group were higher than those in low VE group (t = 2.93, t = 2.06, t = 2.13, t = 2.27, P < 0.05). Social DQ in high cord lead group was significantly lower than that in low lead group (\u03c7(2) = 5.56, P = 0.015). Cord VC level in high cadmium group was significantly lower than that in low cadmium group (\u03c7(2) = 7.62, P = 0.006). VA placental transport ratio in high mercury group was significantly lower than those in low mercury group (\u03c7(2) = 8.02, P = 0.005).Our data suggested that there may be certain interaction between antioxidant vitamin A, E, C and heavy metals lead, cadmium, mercury. Antioxidant vitamins at delivery may have protective effect on the early neurodevelopment via interaction with the heavy metals.",
        "keywords": [],
        "authors": [
            {
                "name": "Ting-yu Li",
                "org": "Children's Hospital of Chongqing Medical University, Chongqing 400014, China."
            },
            {
                "name": "Xuan Zhang",
                "org": ""
            },
            {
                "name": "Xiao-ping Wei",
                "org": ""
            },
            {
                "name": "Yong-fang Liu",
                "org": ""
            },
            {
                "name": "Ping Qu",
                "org": ""
            },
            {
                "name": "You-xue Liu",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Zhonghua er ke za zhi. Chinese journal of pediatrics",
        "year": 2011
    },
    "A7Uoozk6": {
        "id": "A7Uoozk6",
        "title": "The impact of the nursing clinical pathway to the outcomes of total knee replacement",
        "abstract": "Objective To investigate the impact of applications of the nursing clinical pathway in total knee replacement in the clinical outcomes.Methods The patients undergoing the total knee replacement with the nursing clinical pathway from Feb.2009 to Mar.2011(experimental group) was studied controlled with the patients undergoing the total knee replacement from Jan.2007 to Feb.2009(control group).The frequency of the complications after operation,the average length of hospital stay,the total cost,the HSS knee scores and the satisfactions of the patients were observed.Results The frequency of complications after operation and the total cost of the experimental group was lower than that of the controls.The satisfactions of the patients and the HSS knee scores in the experimental group were much higher than that of the controls.Conclusion The clinical pathway treatment and nursing could reduce the the frequency of complications after operation,increase the satisfactions of the patients and achieve the goals of the qualitative nursing.",
        "keywords": [
            "Nursing",
            "Clinical pathway",
            "Joint replacement"
        ],
        "authors": [
            {
                "name": "TANG Yong-li",
                "org": "Department of Orthopedics,The First Affiliated Hospital of Chongqing Medical University,Chongqing Medical University,Chongqing "
            },
            {
                "name": "ZHANG Guo-hui",
                "org": "Department of Orthopedics,The First Affiliated Hospital of Chongqing Medical University,Chongqing Medical University,Chongqing "
            },
            {
                "name": "CHEN Jie",
                "org": "Department of Orthopedics,The First Affiliated Hospital of Chongqing Medical University,Chongqing Medical University,Chongqing "
            }
        ],
        "venue": "Medical Journal of West China",
        "year": 2011
    },
    "zQupm3o6": {
        "id": "zQupm3o6",
        "title": "Evaluation on the physical development and nutritional status of 350 preschool children",
        "abstract": "OBJECTIVE To evaluate the nutritional status and physical development level of preschool children in the suburb of Chongqing city,China,and to provide evidence for further nutritional intervention. METHODS A total of 350 preschool children who met the inclusion criteria from 3 kindergartens in Banan district of Chongqing were recruited in the present study,the children were measured and assessed their anthropometric data and the level of hemoglobin,vitamin A and zinc. RESULTS The prevalence of the preschool children who drank little milk or dairy products and never eat pluck were 34.26% and 72.00% respectively. The overall prevalence of underweight(WAZ\ufe64-2),stunting(HAZ\ufe64-2),wasting(BAZ\ufe64-2)and overweight or obesity(2\u2264BAZ\ufe643)were 3.14%,5.71%,6.86% and5.85%,respectively. The mean hemoglobin concentration was(117.33\u00b19.77)g/L,The overall prevalence of anemia was 25.14%;While the mean vitamin A concentration was(1.23\u00b10.25)\u03bcmol/L,and the prevalence of vitamin A deficiency(VAD)and marginal vitamin A deficiency(MVAD)were 1.14% and 22.32%,respectively. The mean serum zinc concentration was(12.22\u00b17.00)\u03bcmol/L,and the prevalence of serum zinc insufficient was 25.14%. The correlation coefficients of hemoglobin and vitamin A was r = 0.12,the incidence of anemia was 2.32 \u2013fold higher in children with a lower vitamin A level than in those with a normal vitamin A level. CONCLUSION The overall prevalence of VAD,moderate and severe anemia of the preschoolers was low in this region,but MVAD and mild anemia remained high,while the physical development of children remained relatively low.",
        "keywords": [
            "Hemoglobin",
            "Physical development",
            "Vitamin A",
            "Preschool children",
            "Znc"
        ],
        "authors": [
            {
                "name": "LIU Yong-fang",
                "org": ",LI Yan-yu. *the Children\u2019s Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "CHEN Li",
                "org": ",LI Yan-yu. *the Children\u2019s Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "GONG Min",
                "org": ",LI Yan-yu. *the Children\u2019s Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "JIANG Wei",
                "org": ",LI Yan-yu. *the Children\u2019s Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "LIU You-xue",
                "org": ",LI Yan-yu. *the Children\u2019s Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": ",LI Yan-yu. *the Children\u2019s Hospital of Chongqing Medical University,Chongqing ,China"
            }
        ],
        "venue": "Modern Preventive Medicine",
        "year": 2012
    },
    "005bgDUt": {
        "id": "005bgDUt",
        "title": "Construction of recombinant adenovirus vector containing transcriptional factor activator protein 2\u03b1 and its expression in rat mesenchymal stem cells",
        "abstract": "Objective To construct the recombinant adenovirus vector containing transcriptional factor activator protein(AP) 2\u03b1,infect rat mesenchymal stem cells(MSCs) and determine its expression.Methods AP2\u03b1 gene was amplified from the total RNA of rat PC12 cells by PCR and cloned into adenovirus shuttle plasmid pAdtrace-TOX,and the constructed recombinant plasmid pAdtrace-AP2\u03b1 was subjected to homologous combination with adenovirus skeleton plasmid pAd-Easy1 in E.coli BJ5183.The obtained recombinant adenovirus vector pAd-AP2\u03b1 was transfected to HEK293 cells for packaging.Rat MSCs were infected with the prepared recombinant adenovirus Ad-AP2\u03b1,then observed for expression of RFP by fluorescent microscopy,and determined for expression of AP2\u03b1 by real-time PCR and Western blot.Results The target gene band at a length of about 1 400 bp was observed in recombinant plasmid pAdtrace-AP2\u03b1 by PCR and restriction analysis,of which the sequence was consistent with that reported in GenBank,and was cloned into adenovirus vector correctly.Recombinant adenovirus vector pAd-AP2\u03b1 was successfully packaged in HEK293 cells,and the obtained recombinant adenovirus Ad-AP2\u03b1 reached a titer of 2.6 \u00d7 108 pfu / ml.More than 60% of MSCs were positive for RFP 48 h after infection.Real-time PCR and Western blot showed that the expression level of AP2\u03b1 increased significantly 72 h after infection(P < 0.01).Conclusion Recombinant adenovirus vector containing AP2\u03b1 was successfully constructed,which infected MSCs effectively and enhanced the expression of AP2\u03b1 in MSCs.",
        "keywords": [
            "Transcriptional factor AP2",
            "Mesenchymal stem cells(MSCs)",
            "Adenovirus vector"
        ],
        "authors": [
            {
                "name": "BI Yang",
                "org": "*Nutrition Center,The Children's Hospital of Chongqing Medical University,Chongqing ,China)"
            },
            {
                "name": "GONG Min",
                "org": "*Nutrition Center,The Children's Hospital of Chongqing Medical University,Chongqing ,China)"
            },
            {
                "name": "HE Yun",
                "org": "*Nutrition Center,The Children's Hospital of Chongqing Medical University,Chongqing ,China)"
            },
            {
                "name": "ZHANG Yun",
                "org": "*Nutrition Center,The Children's Hospital of Chongqing Medical University,Chongqing ,China)"
            },
            {
                "name": "CHEN Jie",
                "org": "*Nutrition Center,The Children's Hospital of Chongqing Medical University,Chongqing ,China)"
            },
            {
                "name": "LI Ting-yu",
                "org": "*Nutrition Center,The Children's Hospital of Chongqing Medical University,Chongqing ,China)"
            }
        ],
        "venue": "Chinese Journal of Biologicals",
        "year": 2012
    },
    "crioCL9I": {
        "id": "crioCL9I",
        "title": "Study on the Relation Between Obesity-related Indicators and Metabolism of 1,941 Children in Chongqing",
        "abstract": "Objective: To explore the metabolic status of obese children,and study the relation between obesity-related indicators and metabolism.Methods: One thousand,nine hundred and forty-one children aged 7~11 were recruited with multi-stage sampling,and physical examination and biochemical test were done for them with their serum GLU and lipids measured with automatic biochemical instruments.Results: There were 196 children overweight,accounting for 10.01% of the investigated children;135 children of obesity,accounting for 6.96%.Levels of TG,TC,LDL-C were significantly higher in the groups of overweight and obesity than those in the control group(P<0.05).The level of HDL-C was significantly lower than that in the control group(P<0.05).There was no significant difference of GLU among the three groups(P>0.05).Conclusions: Abnormal metabolism could appear in the obese children and overweight and obese children should have more lipid detections and early intervention.",
        "keywords": [
            "Obesity",
            "Children",
            "Metabolism"
        ],
        "authors": [
            {
                "name": "WEI Xiao-ping",
                "org": "Children's Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "LIU You-xue",
                "org": "Children's Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Children's Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "LI Ting-yu",
                "org": "Children's Hospital of Chongqing Medical University,Chongqing ,China"
            }
        ],
        "venue": "Journal of Pediatric Pharmacy",
        "year": 2010
    },
    "mzuevjTG": {
        "id": "mzuevjTG",
        "title": "Relative factors of breastfeeding cessation in infants before 6-month-old",
        "abstract": "Objective To survey and analyze the relative factors associated with cessation of breastfeeding in the infants younger than 6 months old.Methods A cross sectional study was conducted at the health infants from the outpatient department of child healthcare in our hospital from June 2008 to May 2009.A modified questionnaire based on Infants and Young Children Information Questionnaire was employed for demographic data and detailed feeding practice,including the time and reasons of breastfeeding cessation.The relative factors for breastfeeding cessation in infants younger than 6 months old were collected and analyzed.Results There were 939 valid questionnaires obtained in this study.Among them,46.96%(441 /939) mothers stopped breastfeeding their infants younger than 6 months.In the breastfeeding cessation before 6 months group,38.10%(168 /441),13.38%(59 /441),13.58%(58 /441),11.11%(49 /441),12.93%(57 /441),and 11.34%(50 /441) infants were stopped breastfeeding at the age of \u22641,> 1 to 2,> 2 to 3,> 3 to 4,> 4 to 5,and > 5 to 6 months,respectively.\"Breastfeeding alone did not satisfy infants\u2019demand\"was cited by 74.60% mothers(329 /441) who stopped before 6 months.The other reasons of cessation breastfeeding were\"Mother was lack of time to take care of baby because she need to return to work\"(6.58%,29 /441),Infant had trouble in sucking or latching on breast(6.12%,27 /441),Mother\u2019s illness(5.44%,24 /441),Infant\u2019s illness and Hospitalization(5.44%,24 /441),Mother decided it was time to breastfeeding cessation(0.91%,4 /441) and other reasons(0.91%,4 /441).\"Breastfeeding alone did not satisfy infants\" was a relative factor of cessation of breastfeeding earlier than 6 months(OR = 22.317,95% CI = 15.629 to 31.867).Long time of maternity leave was a protective factor of long-time breastfeeding(OR = 0.493,95% CI = 0.35 to 0.693).Conclusion The relative factors of breastfeeding cessation before 6 months are \"Breastfeeding alone did not satisfy infants\u2019demand\"and\"maternity leave shorter than 6 months\".Strengthening health education of breastfeeding to improve mother\u2019s confidence,using growth charts to guide clinical infant feeding,and extending maternity leave properly would promote the duration of breastfeeding.",
        "keywords": [
            "cessation of breastfeeding",
            "relative factors",
            "breastfeeding"
        ],
        "authors": [
            {
                "name": "Kang Yu",
                "org": "1Department of Child Healthcare,Key Laboratory of Child Development and Disorders of Ministry of Education,Chongqing Key Laboratory of Pediatrics,Chongqing International Science and Technology Cooperation Center for Child Development and Disorders,;2Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders,Children\u2019s Hospital,Chongqing Medical University,Chongqing,,China"
            },
            {
                "name": "Liang Xiaohua",
                "org": "1Department of Child Healthcare,Key Laboratory of Child Development and Disorders of Ministry of Education,Chongqing Key Laboratory of Pediatrics,Chongqing International Science and Technology Cooperation Center for Child Development and Disorders,"
            },
            {
                "name": "Liu Youxue",
                "org": "1Department of Child Healthcare,Key Laboratory of Child Development and Disorders of Ministry of Education,Chongqing Key Laboratory of Pediatrics,Chongqing International Science and Technology Cooperation Center for Child Development and Disorders,"
            },
            {
                "name": "Chen Jie",
                "org": "1Department of Child Healthcare,Key Laboratory of Child Development and Disorders of Ministry of Education,Chongqing Key Laboratory of Pediatrics,Chongqing International Science and Technology Cooperation Center for Child Development and Disorders,"
            },
            {
                "name": "Li Tingyu",
                "org": "1Department of Child Healthcare,Key Laboratory of Child Development and Disorders of Ministry of Education,Chongqing Key Laboratory of Pediatrics,Chongqing International Science and Technology Cooperation Center for Child Development and Disorders,;2Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders,Children\u2019s Hospital,Chongqing Medical University,Chongqing,,China"
            }
        ],
        "venue": "Journal of Third Military Medical University",
        "year": 2013
    },
    "u3IoM7E1": {
        "id": "u3IoM7E1",
        "title": "Effects of vitamin A combined with other micronutrients on nutritional status of 3-6 years old children",
        "abstract": "Objective To explore the effects of vitamin A combined with other micronutrients on the nutritional status in children. Methods According to the method of stratified random cluster sampling, three kindergartens were randomly selected out of 7 in the suburbs of Chongqing. A total of 350 preschool children who met the eligibility criteria, aged between 3-6 years old in the selected kindergartens, were randomly assigned to 3 treatment groups: the vitamin A group (A group), the vitamin A plus Zn group (AZ group), and the vitamin A supplementation with multiple micronutrients group (AMM group). The supplementation lasted for 6 months in the three groups. The height and weight of the participants were measured and the Z-score value was calculated before and after supplementation to evaluate the incidence of malnutrition. Serumvitamin A, Zn, Fe, Ca and hemoglobin levels were also measured before and after the intervention. A questionnaire survey of the general situation, family status and dietary habit of the children was performed before the supplementation; also the dietary nutrient intake of the children during intervention was investigated by a 24-hour dietary recall method. Results The 24-hour dietary recall results showed that vitamin A, Zn and Ca were inadequate in the diet of the 3-6 years old children in our study. Compared with before supplementation, the serum Zn and Fe levels were significantly different in the three groups 6 months after supplementation (all P<0.01), with the increment of Zn level in AZ group being significantly higher than that in the AMM group (P<0.05). The serum vitamin A level in AZ group and AMM group were significantly increased by (0.05\u00b10.23) \u03bcmol/L and (0.09\u00b10.28) \u03bcmol/L (P<0.05, P<0.01), respectively; however, the increase was (0.03\u00b10.27) \u03bc mol/L in A group (P>0.05). The increment of serum vitamin A in AMM group was significantly greater than those in A and AZ groups (all P<0.05); the increment of hemoglobin level in AMM group was also significantly greater than that in A group (P<0.05). Themalnutritions rateswere decreased in the A, AZ and AMM groups to different degrees, and the decreases were not significantly different between the three groups (P>0.05). Conclusion The effect of multiple micronutrient supplementation shows no significant difference on nutritional status in 3-6 aged children compared with the two micronutrient supplementations. Micronutrient supplement for children should be based on the main nutritional problems of them, and the best combination of nutrients should be chosen to improve nutrition and health status of children.",
        "keywords": [
            "Anemia",
            "Micronutrients",
            "Vitamin A",
            "Zinc"
        ],
        "authors": [
            {
                "name": "LIU Yong-fang",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "Li Chen",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "Min Gong",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "LIU You-xue",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "Jie Chen",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "Ping Qu",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "LI Ting-yu",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            }
        ],
        "venue": "Academic Journal of Second Military Medical University",
        "year": 2013
    },
    "5ZH7czFd": {
        "id": "5ZH7czFd",
        "title": "AP2\u03b1 transcriptional activity is essential for retinoid-induced neuronal differentiation of mesenchymal stem cells.",
        "abstract": "Pre-activation of the retinoid signaling pathway by all-trans retinoic acid facilitates neuronal differentiation of mesenchymal stem cells. Using protein/DNA based screening assays, we identified activator protein 2\u03b1 as an important downstream target of all-trans retinoic acid. Although all-trans retinoic acid treatment significantly increased activator protein 2\u03b1 transcriptional activity, it did not affect its expression. Inhibition of activator protein 2\u03b1 with dominant-negative mutants reduced ATRA-induced differentiation of mesenchymal stem cells into neurons and reversed its associated functional recovery of memory impairment in the cell-based treatment of a hypoxic-ischemic brain damage rat model. Dominant-negative mutants of activator protein 2\u03b1 inhibited the expression of neuronal markers which were induced by retinoic acid receptor \u03b2 activation. All-trans retinoic acid treatment increased phosphorylation of activator protein 2\u03b1 and resulted in its nuclear translocation. This was blocked by siRNA-mediated knockdown of retinoic acid receptor \u03b2. Furthermore, we found that retinoic acid receptor \u03b2 directly interacted with activator protein 2\u03b1. In summary, the regulation of all-trans retinoic acid on activator protein 2\u03b1 transcriptional activity was mediated by activation of retinoic acid receptor \u03b2 and subsequent phosphorylation and nuclear translocation of activator protein 2\u03b1. Our results strongly suggest that activator protein 2\u03b1 transcriptional activity is essential for all-trans retinoic acid-induced neuronal differentiation of mesenchymal stem cells.",
        "keywords": [
            "ap2\u03b1",
            "atra",
            "activator protein 2\u03b1",
            "all-trans retinoic acid",
            "gfap",
            "gluc",
            "gaussia luciferase",
            "map-2",
            "mnm",
            "msc",
            "mesenchymal stem cells",
            "nse",
            "neurodifferentiation",
            "rar",
            "retinoic acid receptor \u03b2",
            "tuj1",
            "deleted tad domain",
            "deleted bhlh domain",
            "dnap2\u03b1",
            "dominant negative deletion mutants of ap2\u03b1",
            "glial fibrillary acidic protein",
            "microtubule-associated protein-2",
            "modified neuronal induction medium",
            "neuron specific enolase",
            "neuron-specific class iii beta-tubulin",
            "retinoic acid receptor",
            "\u03b4tad",
            "\u03b4bhlh"
        ],
        "authors": [
            {
                "name": "Yang Bi",
                "org": "Nutritional Research Center, The Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Chongqing Stem Cell Therapy Engineering Technical Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Collaboration Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China."
            },
            {
                "name": "Min Gong",
                "org": "Nutritional Research Center, The Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Chongqing Stem Cell Therapy Engineering Technical Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Collaboration Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China."
            },
            {
                "name": "Yun He",
                "org": "Chongqing Stem Cell Therapy Engineering Technical Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Collaboration Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China."
            },
            {
                "name": "Xiaojian Zhang",
                "org": "Nutritional Research Center, The Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Chongqing Stem Cell Therapy Engineering Technical Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Collaboration Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China."
            },
            {
                "name": "Xiaoqin Zhou",
                "org": "Nutritional Research Center, The Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Chongqing Stem Cell Therapy Engineering Technical Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Collaboration Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China."
            },
            {
                "name": "Yun Zhang",
                "org": "Nutritional Research Center, The Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Chongqing Stem Cell Therapy Engineering Technical Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Collaboration Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China."
            },
            {
                "name": "Guoxin Nan",
                "org": "Nutritional Research Center, The Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Chongqing Stem Cell Therapy Engineering Technical Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Collaboration Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China."
            },
            {
                "name": "Xiaoping Wei",
                "org": "Nutritional Research Center, The Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Chongqing Stem Cell Therapy Engineering Technical Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Collaboration Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China."
            },
            {
                "name": "Youxue Liu",
                "org": "Nutritional Research Center, The Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Chongqing Stem Cell Therapy Engineering Technical Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Collaboration Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China."
            },
            {
                "name": "Jie Chen",
                "org": "Nutritional Research Center, The Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Chongqing Stem Cell Therapy Engineering Technical Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Collaboration Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China."
            },
            {
                "name": "Tingyu Li",
                "org": "Nutritional Research Center, The Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Chongqing Stem Cell Therapy Engineering Technical Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Collaboration Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China."
            }
        ],
        "venue": "The international journal of biochemistry & cell biology",
        "year": 2014
    },
    "8vg044rg": {
        "id": "8vg044rg",
        "title": "AtRA inhibits adipogenic differentiation of bone marrow mesenchymal stem cells in rats",
        "abstract": "Objective To investigate the mechanism of all-trans retinoic acid(atRA) to inhibit the adipogenic differentiation of rat bone marrow mesenchymal stem cells(BMSCs).Methods Rat BMSCs were isolated,incubated and induced to differentiate into adipocytes.AtRA at high concentration(0.1-5.0 \u03bcmol / L) was added to the medium for adipogenic induction.The morphologic changes of BMSCs during differentiation were observed under a light microscope.The effect of atRA on the adipogenic differentiation was analyzed by oil red O staining.The expression of retinoic acid receptors \u03b1 and \u03b3(RAR\u03b1 and RAR\u03b3),CCAAT / enhancer binding protein a(CEBP\u03b1) and peroxisome proliferators-activated receptor \u03b32(PPAR\u03b32) was analyzed by realtime PCR.Results At the concentration of 0.1-5.0 \u03bcmol / L,atRA inhibited rBMSCs from differentiating into adipocytes in a dose-dependent manner.The fat content in differentiated cells was decreased along with the increase of atRA concentration(P < 0.05).Compared with the control group(without adding atRA),the mRNA expression levels of CEBP\u03b1 and PPAR\u03b32 were decreased significantly in the atRA groups(P < 0.05).Compared with the control group,the mRNA expression of RAR\u03b1 in the atRA group(1.0 \u03bcmol / L) was not significantly different(0.008 4 \u00b1 0.001 9 vs 0.009 1 \u00b1 0.001 3,P > 0.05),while the mRNA expression of RAR\u03b3 significantly was increased(0.022 6 \u00b1 0.001 2 vs 0.053 1 \u00b1 0.002 3,P < 0.01).Conclusion AtRA(0.1-5.0 \u03bcmol/L) can inhibit the adipogenic differentiation of rBMSCs by up-regulating the expression of RAR\u03b3 and down-regulating the expression of CEBP\u03b1 and PPAR\u03b32.",
        "keywords": [
            "regulation",
            "all-trans retinoic acid",
            "adipogenesis",
            "bone marrow mesenchymal stem cells"
        ],
        "authors": [
            {
                "name": "Zhang Man",
                "org": "Key Laboratory of Child Development and Disorders of Ministry of Education,Chongqing Key Laboratory of Pediatrics,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder,Children\u2019s Hospital,Chongqing Medical University,Chongqing,,China"
            },
            {
                "name": "Shu Xiulan",
                "org": "Key Laboratory of Child Development and Disorders of Ministry of Education,Chongqing Key Laboratory of Pediatrics,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder,Children\u2019s Hospital,Chongqing Medical University,Chongqing,,China"
            },
            {
                "name": "Li Wendi",
                "org": "Key Laboratory of Child Development and Disorders of Ministry of Education,Chongqing Key Laboratory of Pediatrics,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder,Children\u2019s Hospital,Chongqing Medical University,Chongqing,,China"
            },
            {
                "name": "Liu Jingjing",
                "org": "Key Laboratory of Child Development and Disorders of Ministry of Education,Chongqing Key Laboratory of Pediatrics,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder,Children\u2019s Hospital,Chongqing Medical University,Chongqing,,China"
            },
            {
                "name": "Chen Jie",
                "org": "Key Laboratory of Child Development and Disorders of Ministry of Education,Chongqing Key Laboratory of Pediatrics,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder,Children\u2019s Hospital,Chongqing Medical University,Chongqing,,China"
            },
            {
                "name": "Liu Youxue",
                "org": "Key Laboratory of Child Development and Disorders of Ministry of Education,Chongqing Key Laboratory of Pediatrics,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder,Children\u2019s Hospital,Chongqing Medical University,Chongqing,,China"
            }
        ],
        "venue": "Journal of Third Military Medical University",
        "year": 2013
    },
    "8JQf3su0": {
        "id": "8JQf3su0",
        "title": "Construction of Recombinant Adenovirus Vector Containing Dominant Negative Mutant of Transcriptional Factor AP2\u03b1 and its Expression and Activity in Mesenchymal Stem Cells",
        "abstract": "Activator protein-2\u03b1(AP2\u03b1) transcriptional activity might be a key regulatary point of all-trans-retinoic acid(ATRA) induced neuronal differentiation of mesenchymal stem cells(MSCs),however,the mech-anism is still poorly understood.Dominant negative mutation is a canonical method to study gene function.Taken pAd-AP2\u03b1 plasmid containing AP2\u03b1 full-length sequence as template,AP2\u03b1 sequence deleted bHLH domain and TAD domain were PCR amplified respectively,two adenovirus of dominant negative deletion mutants Ad-dnAP2\u03b1-\u25b3bHLH and Ad-dnAP2\u03b1-\u25b3TAD were constructed by using Ad-Easy system.More than 60 percent of RFP-positive MSCs were observed at 24 h after adenovirus infection.Real-time PCR,Western blot,and immunofluorescence results showed that AP2\u03b1 was located in nucleus,the expression of AP2\u03b1 in MSCs did not change with 24 h ATRA treatment,however,the expression of downstream target genes bcl-2 and c-kit increased.Two dominant negative deletion mutants did not change the mRNA and protein expression of wild type AP2\u03b1,but effectively inhibited the role in activating transcription of AP2\u03b1 on downstream target genes bcl-2 and c-kit.This study provides an important tool in the further study of tran-scription activity of AP2\u03b1 in ATRA induced neuronal differentiation of MSCs.",
        "keywords": [
            "activator protein 2\u03b1",
            "dominant negative mutant",
            "transcriptional factor",
            "mes-enchymal stem cells",
            "adenovirus vector"
        ],
        "authors": [
            {
                "name": "BI Yang",
                "org": "Children's Nutrition Research Center,The Children's Hospital of Chongqing Medical University,Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing ,China"
            },
            {
                "name": "HE Yun",
                "org": "Children's Nutrition Research Center,The Children's Hospital of Chongqing Medical University,Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing ,China"
            },
            {
                "name": "GONG Min",
                "org": "Children's Nutrition Research Center,The Children's Hospital of Chongqing Medical University,Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing ,China"
            },
            {
                "name": "ZHANG Yun",
                "org": "Children's Nutrition Research Center,The Children's Hospital of Chongqing Medical University,Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Children's Nutrition Research Center,The Children's Hospital of Chongqing Medical University,Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing ,China"
            },
            {
                "name": "LI Ting-yu",
                "org": "Children's Nutrition Research Center,The Children's Hospital of Chongqing Medical University,Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing ,China"
            }
        ],
        "venue": "Life Science Research",
        "year": 2011
    },
    "fRuREY0l": {
        "id": "fRuREY0l",
        "title": "All-trans retinoic acid suppresses apoptosis in PC12 cells injured by oxygen and glucose deprivation via the retinoic acid receptor \u03b1 signaling pathway.",
        "abstract": "Vitamin A (VA) has a number of important biological functions in human growth and development. Previous studies by our group demonstrated that the normal VA levels improved recovery of learning and memory function and decreased apoptosis in rats with hypoxic\u2011ischemic brain damage (HIBD). However, it has not been fully elucidated how VA regulates the apoptosis of neuronal cells. To investigate the anti\u2011apoptotic effect of VA, an in vitro oxygen glucose deprivation (OGD) model in PC12 cells was treated with four concentrations of all\u2011trans\u2011retinoic acid (ATRA), an active in vivo product of VA. Following in vitro OGD injury in PC12 cells, the percentage of apoptosis and the fluorescence intensity of the mitochondrial membrane potential (MMP) were increased in the cells, and the expression levels of B-cell lymphoma-associated X (Bax) were enhanced. ATRA treatment at 2\u20114 \u00b5mol/l for 24 h decreased the percentage of apoptosis and the MMP of the PC12 cells injured by OGD. ATRA at 4 \u00b5mol/l also reduced the expression levels of Bax and enhanced the expression of B-cell lymphoma 2. Furthermore, RNA interference with retinoic acid receptor \u03b1 (RAR\u03b1) reversed the observed effect in PC12 cells following ATRA treatment at 4 \u00b5mol/l alone. In conclusion, the present study suggested that treatment with ATRA at 4 \u00b5mol/l suppressed apoptosis of PC12 cells following OGD injury, potentially through regulation of the RAR\u03b1 signaling pathway.",
        "keywords": [
            "cell cycle",
            "cancer",
            "gene",
            "apoptosis",
            "molecular medicine",
            "cell",
            "oncology"
        ],
        "authors": [
            {
                "name": "Xiaojian Zhang",
                "org": "Children's Nutritional Research Center, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China."
            },
            {
                "name": "Qin Yu",
                "org": "Children's Nutritional Research Center, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China."
            },
            {
                "name": "Wei Jiang",
                "org": "Children's Nutritional Research Center, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China."
            },
            {
                "name": "Yang Bi",
                "org": "Children's Nutritional Research Center, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China."
            },
            {
                "name": "Yun Zhang",
                "org": "Children's Nutritional Research Center, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China."
            },
            {
                "name": "Min Gong",
                "org": "Children's Nutritional Research Center, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China."
            },
            {
                "name": "Xiaoping Wei",
                "org": "Children's Nutritional Research Center, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China."
            },
            {
                "name": "Tingyu Li",
                "org": "Children's Nutritional Research Center, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China."
            },
            {
                "name": "Jie Chen",
                "org": "Children's Nutritional Research Center, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China."
            }
        ],
        "venue": "Molecular medicine reports",
        "year": 2014
    },
    "MURaVRF6": {
        "id": "MURaVRF6",
        "title": "Effects of vitamin A, vitamin A plus iron and multiple micronutrient-fortified seasoning powder on iron metabolic homeostasis]",
        "abstract": "To evaluate the effect of vitamin A, vitamin A plus iron and \"7 + 1\" multiple micronutrient-fortified seasoning powder on iron metabolic homeostasis in preschool children.This was a randomized, controlled and blinded interventional field trial. A total of 226 2 - 7 years old preschool children were recruited from three nurseries in the area, and they were randomly assigned into three different fortified diet groups for 6 months. The subjects in Group I were fortified with vitamin A; those in Group II and III were fortified with vitamin A plus iron and vitamin A plus iron, thiamine, riboflavin, folic acid, niacinamide, zinc and calcium (7 + 1), respectively. The concentration of serum vitamin A was measured by high-performance liquid chromatography (HPLC), serum ferritin (SF) was measured by enzyme-linked immunosorbent assay (ELISA), soluble transferrin receptor (sTfR) was measured by microparticle-enhanced, and hemoglobin (HB) by hemiglobincyanide, the sTfR-SF index (TFR-F index) and total body iron content were computed respectively before and after intervention. Simultaneously, children's demographic data, socio-economic status and eating habits, etc. were investigated by questionnaires.A total of 226 preschool children were included in the study with age ranged from 2 to 7 years with average age (4.0 \u00b1 0.85) (means \u00b1 standard deviation). The prevalence of anemia, deficient iron storage, vitamin A deficiency (VAD) and suspect sub-clinical vitamin A deficiency (SSVAD) were 23.5%, 15.0%, 6.3% and 25.9%, respectively. The levels of SF and sTfR significantly decreased after intervention in all groups (\u03c7(2) = 8.3298, \u03c7(2) = 16.1471, \u03c7(2) = 15.1371, \u03c7(2) = 15.1171, \u03c7(2) = 5.2617, \u03c7(2) = 4.8844, P < 0.05) especially in group II and group III for SF (\u03c7(2) = 16.1471, \u03c7(2) = 15.1371, P < 0.05) and group I for sTfR (\u03c7(2) = 15.1171, P < 0.05). No marked change of TFR-F index and total body iron contents was observed in group I (t = 0.1817, t = 1.7736, P > 0.05), while TFR-F index decreased and total body iron contents increased in group II and group III (t = 5.3561, t = 6.5979, t = 11.1663, t = 8.7306, P < 0.05) after intervention.Vitamin A intervention has significant effect on iron storage and mobilization but seldom effect on iron absorption in small intestine. The combination of vitamin A and other micronutrients might be a better intervention for the improvement of iron deficiency for preschool-children.",
        "keywords": [],
        "authors": [
            {
                "name": "Ke Chen",
                "org": "Children's Nutrition Research Center, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China."
            },
            {
                "name": "Yong-fang Liu",
                "org": ""
            },
            {
                "name": "Li Chen",
                "org": ""
            },
            {
                "name": "Xuan Zhang",
                "org": ""
            },
            {
                "name": "You-xue Liu",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Ting-yu Li",
                "org": ""
            }
        ],
        "venue": "Zhonghua er ke za zhi. Chinese journal of pediatrics",
        "year": 2011
    },
    "1Xxh4G1J": {
        "id": "1Xxh4G1J",
        "title": "Increased Serum Omentin and Its mRNA Expression in High-fat Diet Induced Obese Rats",
        "abstract": "Obese populations have significantly lower plasma omentin levels than lean ones,but the serum omentin level and its mRNA expression in omental adipose tissue in normal and high fat diet-induced obese rats is not clear.Male adult Sprague-Dawley rats were randomly divided into 2 groups: 10 rats in control group fed with normal diet,30 rats in experimental group with high fat diet(HFD).After 6 weeks,10 rats were randomly chosen from the top 20 rats with the highest weight gain.The experimental rats(n=10) were fed with HFD for another 6 weeks,after 12 weeks,only 9 rats were left in each group.At the end,blood samples were taken for the measurement of serum lipids,glucose,insulin and omentin.Adipose tissue sam-ples were taken for determination of the mRNA expression of omentin by RT-PCR.The results showed that after 12 weeks of high fat diet feeding,body weight,weight gain,the obesity index,LDL,insulin,serum o-mentin level and its mRNA expression in omental adipose tissue were significantly higher in HFD group rats than those in control group(P<0.05 for all comparisons).It is the first time to document that serum omentin and its mRNA expression in omental adipose tissue are increased in high fat diet-induced obese rats.It was inconsistent with the results found in population-based studies.",
        "keywords": [
            "omentin",
            "obese rats",
            "high-fat diet"
        ],
        "authors": [
            {
                "name": "QU Ping",
                "org": "Children's Hospital of Chongqing Medical University,Key Laboratory of Developmental Diseases in Childhood of Ministry of Education,Key Laboratory of Pediatrics in Chongqing,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder,Chongqing ,China"
            },
            {
                "name": "BI Yang",
                "org": "Children's Hospital of Chongqing Medical University,Key Laboratory of Developmental Diseases in Childhood of Ministry of Education,Key Laboratory of Pediatrics in Chongqing,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder,Chongqing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Children's Hospital of Chongqing Medical University,Key Laboratory of Developmental Diseases in Childhood of Ministry of Education,Key Laboratory of Pediatrics in Chongqing,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder,Chongqing ,China"
            },
            {
                "name": "ZHANG Man",
                "org": "Children's Hospital of Chongqing Medical University,Key Laboratory of Developmental Diseases in Childhood of Ministry of Education,Key Laboratory of Pediatrics in Chongqing,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder,Chongqing ,China"
            },
            {
                "name": "LIU You-xue",
                "org": "Children's Hospital of Chongqing Medical University,Key Laboratory of Developmental Diseases in Childhood of Ministry of Education,Key Laboratory of Pediatrics in Chongqing,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder,Chongqing ,China"
            }
        ],
        "venue": "Life Science Research",
        "year": 2012
    },
    "bl5dqAx9": {
        "id": "bl5dqAx9",
        "title": "Effect of micro-environment for induction on neuronal differentiation of Mescenchymal Stem Cells (MSCs) and spontaneous dedifferentiation of differentiated MSCs",
        "abstract": "Objective: To induce the differentiation of rat bone marrow mesenchymal stem cells (MSCs) into neural-like cells in vitro and investigate the effect of micro-environment for induction on the differentiation as well as spontaneous dedifferentiation of differentiated MSCs. Methods: Rat MSCs were isolated and cultured in vitro, and determined for surface markers by flow cytometry, then induced with modified neuronal induction medium (MNM) and determined for the surface markers of neurocytes by IFA. The effects of micro-environment for induction, such as FBS concentration, MNM dosage, fresh and used MNM, on the neuronal differentiation of MSCs were observed. Results: Nissl bodies as well as neural specific surface markers including neuron-specific enolase (NSE), nestin and microtubule-associated protein-2 (MAP-2) were observed in the MSCs 6 h after induction with MNM. The neuronal differentiation rate of MSCs and the expressions of neural specific surface markers changed with the change of micro-environment for induction, and the neural-like cells could be dedifferentiated spontaneously back into MSC-like cells. Conclusions: MSCs could be differentiated into neural-like cells under induction of MNM, however, the change of micro-environment for induction influenced the differentiation of MSCs in both quality and quantity.",
        "keywords": [
            "Bone marrow mesenchymal stem cells",
            "Micro-environment",
            "Neuronal differentiation",
            "Spontaneous dedifferentiation"
        ],
        "authors": [
            {
                "name": "Min Gong",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "Yang Bi",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "Wei Jiang",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "ZHANG Xiao-juan",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "Yun Zhang",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "WEI Xiao-ping",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "Jie Chen",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "Youxue Liu",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "LI Ting-yu",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            }
        ],
        "venue": "Chinese Journal of Biologicals",
        "year": 2010
    },
    "lw3stGo2": {
        "id": "lw3stGo2",
        "title": "Survey on growth level,anemia and vitamin A deficiency among 356 primary and middle school students in wuxi county of Chongqing city",
        "abstract": "Objective To evaluate the growth level\u3001the prevalence of anemia and vitamin A deficiency among children at primary and middle schools in Wuxi county of Chongqing.Methods 356 children aged from 7 to 19 years were selected randomly from 2 primary and 2 middle schools in the Wuxi County,Chongqing,China.Their height and weight were measured respectively.At the same time,the levels of Haemoglobin and vitamin A were also determined.Results The prevalence of vitamin A deficiency was 14.6%,and doubtful subclinical vitamin A deficiency 50.8%.The ratio of vitamin A deficiency in the students of primary school was higher than that in the middle school.The prevalence of anemia was 18.3% in all subjects.There was positive correlation between the levels of vitamin A and Haemoglobin(r=0.008).The prevalence of stunting and wasting was 24.7% and 6.2%,respectively.Conclusion The prevalence of anemia,stuning,wasting,and vitamin A deficiency was higher in the Wuxi County,suggesting us to pay attention to the students\u2032 nutrition status at primary and middle schools of poverty-stricken areas such as Wuxi county.",
        "keywords": [
            "height",
            "anemia",
            "vitamin A",
            "body weight"
        ],
        "authors": [
            {
                "name": "Jiang Hongpeng",
                "org": "Children\u2032s Nutrition Research Center"
            },
            {
                "name": "Wei Xiaoping",
                "org": "Children\u2032s Nutrition Research Center"
            },
            {
                "name": "Tang Xianqiang",
                "org": "the Office of President"
            },
            {
                "name": "Liu Youxue",
                "org": "Children\u2032s Nutrition Research Center"
            },
            {
                "name": "Chen Jie",
                "org": "Children\u2032s Nutrition Research Center"
            },
            {
                "name": "Chen Li",
                "org": "Children\u2032s Nutrition Research Center;Department of Child Health Care,Children\u2032 s Hospital,Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "Li Tingyu",
                "org": "Children\u2032s Nutrition Research Center;Department of Child Health Care,Children\u2032 s Hospital,Chongqing Medical University,Chongqing ,China"
            }
        ],
        "venue": "Chongqing Medicine",
        "year": 2012
    },
    "nBM0wnJQ": {
        "id": "nBM0wnJQ",
        "title": "Construction and functional identification of rat siTLR4 recombinant adenovirus vector",
        "abstract": "We aimed to construct the recombinant adenovirus vector carrying specific small interfering RNA(siRNA) targeting TLR4 gene of rat,for further research of the immunoregulatory mechanisms of TLR4 in different diseases.Three pairs of siRNA sequence for silencing rat TLR4 gene were designed,then annealed and cloned into the pSES-HUS vector in order to gain pSES-HUS-siTLR4 plasmid.After the recombinant vector was linearized by Pme I,the pAd-siTLR4 plasmid was obtained by homologous recombination between the pSES-HUS-siTLR4 and the backbone vector pAdEasy-1 in E.coli BJ5183.Afterward,the pAd-siTLR4 plasmid was transfected into HEK293 cells through Lipofectamine 2000 to package Ad-siTLR4 recombinant adenovirus.Then Ad-siTLR4 recombinant adenovirus was used to infect PC12 cells,and the levels of TLR4 mRNA and protein expression were detected by Real-time PCR and Western blotting.We also tested the changes of NF-\u03baB expression,which is a key protein in the TLR4 signaling pathway.Real-time PCR and Western blotting indicated that TLR4 mRNA and protein levels were significantly reduced in infected PC12 cells.Meanwhile,the expression level of NF-\u03baB was also obviously decreased.All of these suggested that the pAd-siTLR4 recombinant adenovirus vector was constructed successfully and Ad-siTLR4 recombinant adenovirus could effectively suppress TLR4 expression and obviously reduce level of NF-\u03baB expression in PC12 cells.",
        "keywords": [
            "immunoregulation",
            "sirna",
            "recombinant adenovirus vector",
            "tlr4",
            "nf-\u03bab"
        ],
        "authors": [
            {
                "name": "ZHANG Yun",
                "org": " Children's Nutrition Research Center,Children's Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "BI Yang",
                "org": " Children's Nutrition Research Center,Children's Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "GONG Min",
                "org": " Children's Nutrition Research Center,Children's Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "JIANG Wei",
                "org": " Children's Nutrition Research Center,Children's Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "WEI Xiaoping",
                "org": " Children's Nutrition Research Center,Children's Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "LI Tingyu",
                "org": " Children's Nutrition Research Center,Children's Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": " Children's Nutrition Research Center,Children's Hospital of Chongqing Medical University,Chongqing ,China"
            }
        ],
        "venue": "Immunological Journal",
        "year": 2012
    },
    "A9WDtPBy": {
        "id": "A9WDtPBy",
        "title": "Progress of vitamin A deficiency affecting on intestinal epithelial barrier function",
        "abstract": "Vitamin A plays important roles on maintaining epithelial barrier integrity,regulating mucosal immune function against several infections.Retinoic acid synthesizing enzymes(RALDH) is expressed in the gut-associated dendritic cells to produce RA.RA can up-regulate expression levels of integrin \u03b14\u03b27\u3001CCR9 of T and B lymphocytes,which enhance the T and B lymphocytes preferentially homing to the small intestine and induce secretion of immunoglobulin-A(IgA).RA also promotes the differentiation of native CD4+T cells into Foxp3+ inducible regulatory T cells(Treg),and represses the proliferation of Th17 cells.Increasing evidences have demonstrated that vitamin A deficiency may decrease intestinal epithelial barrier function and down-regulate intestinal local mucosal immune responses,resulting in increased susceptibility of intestinal infection and risk of diarrhea.The current paper reviewed the regulatory effects of vitamin A on the intestinal barrier function.",
        "keywords": [
            "mucosal immune response",
            "intestinal barrier function",
            "vitamin A"
        ],
        "authors": [
            {
                "name": "LIU Xia",
                "org": "Children\u2019s Nutrition Research Center,Key Laboratory of Developmental Diseases in Childhood of Ministry of Education,Key Laboratory of Pediatrics in Chongqing,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder,Children\u2019s Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "LI Ting-Yu",
                "org": "Children\u2019s Nutrition Research Center,Key Laboratory of Developmental Diseases in Childhood of Ministry of Education,Key Laboratory of Pediatrics in Chongqing,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder,Children\u2019s Hospital of Chongqing Medical University,Chongqing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Children\u2019s Nutrition Research Center,Key Laboratory of Developmental Diseases in Childhood of Ministry of Education,Key Laboratory of Pediatrics in Chongqing,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder,Children\u2019s Hospital of Chongqing Medical University,Chongqing ,China"
            }
        ],
        "venue": "Chinese Bulletin of Life Sciences",
        "year": 2012
    },
    "Mj8pWbT3": {
        "id": "Mj8pWbT3",
        "title": "Regulation effects of the bone marrow-derived mesenchymal stem cells in local microenvironment of injury tissue",
        "abstract": "Bone marrow-derived mesenchymal stem cells(MSCs) are a kind of self-renewal and multipotential cells,and have restoration effects on injured tissue following transplantation in vivo. However,the low differentiation efficiency(less than 10%) of MSCs in vivo could not explain its recovery function in theory. Recent studies have reported that MSCs can regulate the local injury microenvironment via paracrinal pathways and facilitate the restore of impaired tissues,indicating that the microenvironment regulation of MSCs plays more important role than its differentiation in clinical recovery. The current paper reviewed the regulatory effects of MSCs in local microenvironment of damaged tissue,providing theoretical basis for broadly clinical application of MSCs transplantation therapy.",
        "keywords": [
            "regulation of microenvironment",
            "mesenchymal stem cells (MSCs)",
            "injured tissue"
        ],
        "authors": [
            {
                "name": "ZHANG Yun",
                "org": "Children's Nutrition Research Center,Children's Hospital of Chongqing Medical University, Chongqing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Children's Nutrition Research Center,Children's Hospital of Chongqing Medical University, Chongqing ,China"
            },
            {
                "name": "LI Ting-yu",
                "org": "Children's Nutrition Research Center,Children's Hospital of Chongqing Medical University, Chongqing ,China"
            }
        ],
        "venue": "Chinese Bulletin of Life Sciences",
        "year": 2010
    },
    "ijWmscVF": {
        "id": "ijWmscVF",
        "title": "Inhibitory effect of vitamin A deficiency during pregnancy on N-methyl-D-aspartate-induced Ca~(2+) influx of neurons in newborn rats",
        "abstract": "Objective To study the effect of vitamin A deficiency during pregnancy on N-methyl-D-aspartate(NMDA)-induced Ca2+ influx of hippocampal neurons in newborn rats.Methods Sixteen healthy male Wistar rats were randomly divided into vitamin A deficiency group(n=8) and normal vitamin A group(n=8),and fed with vitamin A deficient breed and vitamin A sufficient breed,respectively,3 weeks before copulation.Serum vitamin A level was measured by high performance liquid chromatography.Changes of Ca2+ in primarily cultured hippocampal neurons of newborn rats were detected with a calcium imaging detector after treatment with NMDA.Expression of NMDA receptor 1 in hippocampus was detected by Western blotting.Results The serum vitamin A level was lower in vitamin A deficient group than in vitamin A sufficient group of mother and newborn rats [(0.768\u00b10.069)\u03bcmol/L and(0.806\u00b10.092)\u03bcmol/L vs(1.284\u00b10.217)\u03bcmol/L and(1.270\u00b10.098) \u03bcmol/L,P<0.01].Immunofluorescence showed no significant difference in neuron-specific enolase(NSE),between the 2 groups.The ratio of hippocampal neurons was lower in vitamin A deficient group than in vitamin A sufficient group after treatment with NMDA [(0.136\u00b10.012) vs(0.168\u00b10.022),P<0.01].Western blot analysis showed that the expression level of NMDA receptor 1 was significantly lower in vitamin A deficient group than in vitamin A sufficient group[(2.527\u00b10.245) vs(1.157\u00b10.197),P<0.05].Conclusion Vitamin A deficiency during pregnancy inhibits Ca2+ influx of hippocampal neurons in newborn rats by decreasing the expression of NMDA receptor 1 in the hippocampus,which may be one of the mechanisms underlying cell damage.",
        "keywords": [
            "Western blotting",
            "primary neuron culture",
            "calcium imaging",
            "marginal vitamin A deficiency"
        ],
        "authors": [
            {
                "name": "Zhang Xiaojuan",
                "org": "Nutritional Research Center,Children's Hospital,Chongqing Medical University,Chongqing,,China"
            },
            {
                "name": "Bi Yang",
                "org": "Nutritional Research Center,Children's Hospital,Chongqing Medical University,Chongqing,,China"
            },
            {
                "name": "He Jian",
                "org": "Nutritional Research Center,Children's Hospital,Chongqing Medical University,Chongqing,,China"
            },
            {
                "name": "Liu Youxue",
                "org": "Nutritional Research Center,Children's Hospital,Chongqing Medical University,Chongqing,,China"
            },
            {
                "name": "Chen Jie",
                "org": "Nutritional Research Center,Children's Hospital,Chongqing Medical University,Chongqing,,China"
            },
            {
                "name": "Qu Ping",
                "org": "Nutritional Research Center,Children's Hospital,Chongqing Medical University,Chongqing,,China"
            },
            {
                "name": "Li Tingyu",
                "org": "Nutritional Research Center,Children's Hospital,Chongqing Medical University,Chongqing,,China"
            }
        ],
        "venue": "Acta Academiae Medicinae Militaris Tertiae",
        "year": 2010
    },
    "VKsZBiaC": {
        "id": "VKsZBiaC",
        "title": "Effect of dietary vitamin A intake on plasma vitamin A concentration in preschool children of Banan district, Chongqing, China]",
        "abstract": "To study the relationship between dietary vitamin A intake and plasma vitamin A concentration, and establish the theoretical basis for dietary intake predicting vitamin A nutritional status.By using cluster sampling, 492 children aged 2-7 years in kindergartens in Banan district of Chongqing were selected. A cross-sectional nutrition and health survey was conducted, including the clinical examination, anthropometry, laboratory test and dietary survey.Among the children surveyed, 229 were boys, and 263 girls, the mean age was (4.54 \u00b1 0.87) years, height (107.50 \u00b1 7.20) cm, and weight (18.42 \u00b1 3.41) kg, the mean value of plasma vitamin A was (1.04 \u00b1 0.30) \u03bcmol/L. The prevalence of marginal vitamin A deficiency (MVAD) was 43.5%. No cases of severe clinical vitamin A deficiency were found (plasma vitamin A \u2264 0.35 \u03bcmol/L). Clinical examination found no conjunctiva, corneaor skin abnormalities, and no Bitot's spots. Prevalence of the last two weeks colds were 27.4% (135/492), no diarrhea and other gastrointestinal or digestive diseases were found. The proportion of insufficient dietary vitamin A intake (<600 \u03bcg RE/d) was as high as 50.0%. By using correlation analysis, plasma retinol concentrations were related to dietary vitamin A intake (r=0.162, P<0.001), and to dietary energy intake (r=0.107, P=0.017). After adjustment for the effects of other non-dietary factors on vitamin A deficiency, the multivariate logistic regression showed that vitamin A-rich foods of liver intake=0 g/d (OR=1.95, 95% CI: 1.05-3.61, P=0.034), vitamin A-rich fruits intake=0 g/d (OR=1.55, 95% CI: 1.03-2.33, P=0.034), vitamin A-rich vegetables intake<200 g/d (OR=3.47, 95% CI: 1.37-8.75, P=0.009) were important risk factors of vitamin A deficiency. But we had not found the correlation between the intake of meat, eggs and milk and vitamin A deficiency.Dietary factors may be the major risk factor of vitamin A deficiency in the three kindergartens. The dietary vitamin A intakes are significantly related to plasma retinol concentrations, and the vitamin A-rich foods intakes can predict the body's vitamin A nutritional status.",
        "keywords": [],
        "authors": [
            {
                "name": "Rong Peng",
                "org": "Children's Nutrition Research Center, Children's Hospital of Chongqing Medical University, Chongqing 400014, China; School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China."
            },
            {
                "name": "Xiao-ping Wei",
                "org": "Children's Nutrition Research Center, Children's Hospital of Chongqing Medical University, Chongqing 400014, China."
            },
            {
                "name": "Xiao-hua Liang",
                "org": "Children's Nutrition Research Center, Children's Hospital of Chongqing Medical University, Chongqing 400014, China."
            },
            {
                "name": "Jie Chen",
                "org": "Children's Nutrition Research Center, Children's Hospital of Chongqing Medical University, Chongqing 400014, China."
            },
            {
                "name": "You-xue Liu",
                "org": "Children's Nutrition Research Center, Children's Hospital of Chongqing Medical University, Chongqing 400014, China."
            },
            {
                "name": "Ting Zhang",
                "org": "The Capital Institute of Pediatrics, Beijing 100020, China."
            },
            {
                "name": "Ting-yu Li",
                "org": "Children's Nutrition Research Center, Children's Hospital of Chongqing Medical University, Chongqing 400014, China."
            }
        ],
        "venue": "Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences",
        "year": 2014
    },
    "su8hv9U1": {
        "id": "su8hv9U1",
        "title": "Calcium excitability of rat primary hippocampal neuron damaged by silenced retinoic acid receptor \u03b1",
        "abstract": "Objective: To study the necessary of retinoic acid receptor \u03b1 (RAR\u03b1) for rat neuron function. Methods: Tissue digestion was used to isolate and cultivate the rat primary hippocampal neurons, and the adenovirus vector was used to specifically silence the RAR\u03b1; Real-Time PCR was used to analyze the influence of silenced RAR\u03b1 in retinoic acid (RA) receptors and the markers of nerve cells; live cell imaging analysis was performed to analyze the influence of the calcium excitability of neurons silenced RAR\u03b1. Results: The immunofluorescence results showed that 90% of the isolated cells expressed the neuron marker neuron-specific enolase (NSE), the adenoviral transfection efficiency was up to 80%. The PCR results showed the expression of RAR\u03b1 in silenced RAR\u03b1 neuron was decreased by 75% (P<0.01), the other receptors were significantly decreased (P<0.01), but RAR\u03b2 was significantly increased (P<0.05). The live cell calcium imaging results showed the calcium excitability in silent group was significantly reduced (P<0.05), however all-trans retinoic acid (ATRA) pretreatment for 24 h could significantly enhance the calcium excitability (P<0.01). Conclusion: The absence of RAR\u03b1 can significantly reduce the neuron marker NSE expression of the primary hippocampal neurons, and significantly damage the neuronal calcium excitability.",
        "keywords": [
            "Calcium excitability",
            "Gene silence",
            "Primary hippocampal neurons",
            "Retinoic acid",
            "Retinoic acid receptor \u03b1"
        ],
        "authors": [
            {
                "name": "Wei Jiang",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "Qin Yu",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "Min Gong",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "Yang Bi",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "Yun Zhang",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "Li Chen",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "Pin Qu",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "XiaoPing Wei",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "LIU You-xue",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "Jie Chen",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "LI Ting-yu",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            }
        ],
        "venue": "Journal of Jilin University(Medicine Edition)",
        "year": 2011
    },
    "TynDvYKr": {
        "id": "TynDvYKr",
        "title": "Cobalt chloride post-conditioning improves spatial working memory in rats of neonatal hypoxic-ischemic encephalopathy",
        "abstract": "Objective To determine the effect of cobalt chloride(CoCl2) post-conditioning on the spatial working memory in neonatal rats with hypoxic-ischemic induced brain damage(HIBD).Methods Sixty-six SD rats aged 7 d were randomly divided into sham operation group(N,n=16),hypoxia-ischemia group(HI,n=18),CoCl2 administration immediately after surgery group(C1,n=14) and CoCl2 administration 1 d after surgery group(C2,n=18).The left common carotid artery of rats were ligated after anesthesia followed by hypoxia.In the sham control group,the left common carotid artery was exposed but was not ligated or exposed to hypoxia.The brain tissues were harvested from the pups in each group at 1,2 and 7 d after ligation.HIF-1\u03b1 expression was detected by Western blot analysis.At age of 7 weeks,pups of each group were trained to do the Morris water maze test to evaluate their spatial learning and memory abilities.Results HIF-1\u03b1 expression was up-regulated in HI,C1 and C2 groups at post operation days 1 and 2,then decreased,and even not detectable in the former 2 groups at postoperative day 7,but detectable in C2 group.Morris water maze training revealed that the rats in C2 group had significantly shortened average latency time at 3 to 5 d,and improved long-term reference memory compared with that in HI group(P<0.05).Conclusion CoCl2 improves and maintains the expression of HIF-1\u03b1 in newborn rats after hypoxic-ischemic induced brain damage.Post-conditioning with CoCl2 at 1 d after hypoxic-ischemic damage exerts neuroprotection and restores spatial working memory.",
        "keywords": [
            "hypoxia-inducible factor",
            "CoCl2",
            "spatial working memory",
            "hypoxic-ischemic brain damage"
        ],
        "authors": [
            {
                "name": "Li Wendi",
                "org": "1Department of Primary Child Healthcare,;2Children's Nutritional Research Center,Key Laboratory of Developmental Diseases in Childhood of Ministry of Education,Chongqing Key Laboratory of Pediatrics,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder,"
            },
            {
                "name": "Zhong Min",
                "org": "3Department of Neurology,Children's Hospital,Chongqing Medical University,Chongqing,,China"
            },
            {
                "name": "Liu Youxue",
                "org": "2Children's Nutritional Research Center,Key Laboratory of Developmental Diseases in Childhood of Ministry of Education,Chongqing Key Laboratory of Pediatrics,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder,"
            },
            {
                "name": "Chen Jie",
                "org": "2Children's Nutritional Research Center,Key Laboratory of Developmental Diseases in Childhood of Ministry of Education,Chongqing Key Laboratory of Pediatrics,Chongqing International Science and Technology Cooperation Center for Child Development and Disorder,"
            },
            {
                "name": "Cheng Qian",
                "org": "1Department of Primary Child Healthcare,"
            },
            {
                "name": "Li Tingyu",
                "org": "1Department of Primary Child Healthcare,"
            },
            {
                "name": "Dai Ying",
                "org": "1Department of Primary Child Healthcare,"
            }
        ],
        "venue": "Journal of Third Military Medical University",
        "year": 2013
    },
    "PhUAIyq1": {
        "id": "PhUAIyq1",
        "title": "Drug Resistance of Pseudomonas aeruginosa:Four Year Dynamics and Clinical Antimicrobial Strategy",
        "abstract": "OBJECTIVE To analyze the change in antibiotic resistance of Pseudomonas aeruginosa(PAE) in our hospital during the past four years for reference of clinical antimicrobial strategy.METHODS Data from Jan 2005 to Dec 2008 were collected of the 982 P.aeruginosa strains isolated from clinical specimens.Drug sensitivity to 20 antimicrobial agents were tested.RESULTS The drug resistance rates were mostly higher than 90.00%,including to ampicillin,amoxicillin/clavulanic acid,ampicillin/sulbactam,cefotetan,cephazolin,furadantin,and trimethoprim/sulfamethoxazole,but to meropenem was 51.51%.Some drug sensitive rates were higher than 60.00%,including gentamicin,ceftazidime,cefepime,cefoperazone/sulbactam,and ciprofloxacin.But the resistance rate to amikacin and tobramycin was the lowest.CONCLUSIONS The resistance of PAE to the most of the antibiotics is increasing in clinical specimens.Antimicrobial treatment should be guided by drug sensitivity test.",
        "keywords": [
            "Drug resistance",
            "Nosocomial infection",
            "Pseudomonas aeruginosa"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "The First Affiliated Hospital,Wenzhou Medical College,Wenzhou,Zhejiang ,China"
            },
            {
                "name": "PAN Jing-ye",
                "org": "The First Affiliated Hospital,Wenzhou Medical College,Wenzhou,Zhejiang ,China"
            },
            {
                "name": "WANG Xiao-rong",
                "org": "The First Affiliated Hospital,Wenzhou Medical College,Wenzhou,Zhejiang ,China"
            },
            {
                "name": "MA Ji-hong",
                "org": "The First Affiliated Hospital,Wenzhou Medical College,Wenzhou,Zhejiang ,China"
            },
            {
                "name": "ZHOU Xiao-jie",
                "org": "The First Affiliated Hospital,Wenzhou Medical College,Wenzhou,Zhejiang ,China"
            }
        ],
        "venue": "Chinese Journal of Nosocomiology",
        "year": 2010
    },
    "rIOLZRH8": {
        "id": "rIOLZRH8",
        "title": "A Nested-PCR Method Established to Detect Human Papillomavirus and Its the Preliminary Clinical Practice",
        "abstract": "OBJECTIVE To establish a nested-PCR(nPCR) method to detect the human papillomavirus and analyzed its preliminary clinical practice.METHODS MY09/MY11 was as outer primer and GP5+/GP6+ as inner primer to establish a nPCR and optimiz the PCR reaction system,and its specificity and sensitivity were appraised.The 54 HPV positive samples,4 weak positive samples,and 42 negative samples were simultaneously detected by nPCR and compared with the flow-through hybridization.RESULTS The established nPCR method could detect the sole goal segment and 1\u223616 384 dilution HPV18 positive control,so it was more obviously sensitive than the MY09/MY11.The nPCR method detected 60 HPV positive samples and 40 negative samples,which had the good uniformity with the flow-through hybridization(\u03c72=39.518,P<0.001,Kappa=0.628,P<0.001).CONCLUSIONS The nPCR has the good specificity,sensitivity and uniformity with the flow-through hybridization.",
        "keywords": [
            "Flow-through hybridization",
            "MY09/MY11",
            "Nested polymerase chain reaction",
            "GP5+/GP6+",
            "Human papillomavirus"
        ],
        "authors": [
            {
                "name": "WANG Yu-min",
                "org": "The First Affiliated Hospital,Wenzhou Medical College,Wenzhou,Zhejiang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "The First Affiliated Hospital,Wenzhou Medical College,Wenzhou,Zhejiang ,China"
            },
            {
                "name": "TAO Zhi-hua",
                "org": "The First Affiliated Hospital,Wenzhou Medical College,Wenzhou,Zhejiang ,China"
            },
            {
                "name": "CHEN Zhan-guo",
                "org": "The First Affiliated Hospital,Wenzhou Medical College,Wenzhou,Zhejiang ,China"
            },
            {
                "name": "ZHOU Wu",
                "org": "The First Affiliated Hospital,Wenzhou Medical College,Wenzhou,Zhejiang ,China"
            },
            {
                "name": "HE Jing-jing",
                "org": "The First Affiliated Hospital,Wenzhou Medical College,Wenzhou,Zhejiang ,China"
            }
        ],
        "venue": "Chinese Journal of Nosocomiology",
        "year": 2010
    },
    "SRldf8o5": {
        "id": "SRldf8o5",
        "title": "Drug Resistance of Chryseobacterium meningosepticum:Dynamics and Clinical Antimicrobial Strategy",
        "abstract": "OBJECTIVE To investigate the change in antibiotic resistance of Chryseobacterium meningosepticumin hospital for reference of clinical antimicrobial strategy.METHODS Data were collected of the 247 bacteria strains isolated from clinical specimens from Jan 2005 to Dec 2008.Drug sensitivity tests were made for 17 antimicrobial agents.RESULTS A lot of the drug resistance rates were higher than 90.00%,including meropenem,ampicillin,ampicillin/sulbactam,aztreonam,ceftriaxone,cefazolin,furadantin,gentamicin,tienam,ceftazidime and tobramycin.That of the others such as levofloxacin(10.12%),trimethoprim/sulfamethoxazole(11.34%),ciprofloxacin(9.13%) were lower and had certain trend of escalation.But the resistance rate to sulperazone(4.02%) and piperacillin/tazobactam(2.43%) was the lowest.CONCLUSIONS The resistance to the most of the antibiotics is increasing in clinical specimens.Antimicrobial treatment should be guided by drug sensitivity test.",
        "keywords": [
            "Chryseobacterium meningosepticum",
            "Drug resistance",
            "Nosocomial infection"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "The First Affiliated Hospital,Wenzhou Medical College,Wenzhou,Zhejiang ,China"
            },
            {
                "name": "PAN Jing-ye",
                "org": "The First Affiliated Hospital,Wenzhou Medical College,Wenzhou,Zhejiang ,China"
            },
            {
                "name": "WANG Yu-min",
                "org": "The First Affiliated Hospital,Wenzhou Medical College,Wenzhou,Zhejiang ,China"
            },
            {
                "name": "WANG Xiao-rong",
                "org": "The First Affiliated Hospital,Wenzhou Medical College,Wenzhou,Zhejiang ,China"
            },
            {
                "name": "MA Ji-hong",
                "org": "The First Affiliated Hospital,Wenzhou Medical College,Wenzhou,Zhejiang ,China"
            }
        ],
        "venue": "Chinese Journal of Nosocomiology",
        "year": 2010
    },
    "ZIGG6u2k": {
        "id": "ZIGG6u2k",
        "title": "Application of RIFLE criteria for acute renal failure in patients treated with continuous renal replacement therapy]",
        "abstract": "To determine the optimal timing of treating acute renal failure (ARF) patients in intensive care unit (ICU) with RIFLE (risk of renal failure, injury to the kidney, failure of kidney function, loss of kidney function and end-stage renal failure) classification using continuous renal replacement therapy (CRRT). And to evaluate the association between mortality and RIFLE classification in the same patients.Clinical data were collected from 103 ARF patients in ICU from 2000 to 2007.The 30-days hospital mortality rate was 45.6%. The 30 days' hospital mortality rates of RIFLE-R, RIFLE-I and RIFLE-F were 25.0%, 20.0% and 57.3% respectively.Survival rate of ARF patients can be manifestly elevated if CRRT is performed before RIFLE-F. The patients in RIFLE-F category have a significantly higher mortality than RIFLE-R and -I patients. The RIFLE criteria is fit for ARF classification system.",
        "keywords": [
            "kidney failure",
            "acute",
            "renal replacement therapy",
            "rifle criteria"
        ],
        "authors": [
            {
                "name": "Jing-Ye Pan",
                "org": "Intensive Care Unit, First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China. panjingye@hospl.ac.cn"
            },
            {
                "name": "Fu-Zheng Tao",
                "org": ""
            },
            {
                "name": "Jin-Bo Zhang",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Yue-Yue Huang",
                "org": ""
            },
            {
                "name": "Ji-Hong Ma",
                "org": ""
            },
            {
                "name": "Xiao-Rong Wang",
                "org": ""
            },
            {
                "name": "Dan Wang",
                "org": ""
            }
        ],
        "venue": "Zhonghua yi xue za zhi",
        "year": 2009
    },
    "xDi8x12s": {
        "id": "xDi8x12s",
        "title": "Effects of the Serum in Hemorrhagic Shock Rats on Endothelial Cell Protein C Receptor of Human Umbilical Vein Endothelial Cells",
        "abstract": "Objective:To investigate the effects of the serum in hemorrhagic shock rats and Shenfu injection on endothelial cell's thrombomodul and endothelial cell protein C receptor.Methods:The soluble endothelial protein C receptor(sEPCR) in supernatant,EPCR mRNA and protein of human umbilical vein endothelial cell were detected by enzyme linked Immunosorbent assay(ELISA),reverse transcription polymerase chain reaction(RT-PCR),western bloting(WB) in endothelial cell culturing with serum,normal control,hemorrhagic shock(3h,12h,24h,72h) group respectively.Results:The mean levels of sEPCR,the expression of EPCR mRNA and protein were no significant differences in hemorrhagic shock(3h,72h) group than that in normal control group(all P>0.05).The mean levels of sEPCR and the expression of EPCR mRNA were significantly higher in hemorrhagic shock(12h,24h) group than that in normal control group(all P<0.05),while the level of protein was lower than that in normal control group(both P<0.05).Conclusion:These data suggest that serum in hemorrhagic shock rats could effect sEPCR \u3001EPCR mRNA and protein of human umbilical vein endothelial cells expression.",
        "keywords": [
            "hemorrhagic shock",
            "endothelial cell protein C receptor"
        ],
        "authors": [
            {
                "name": "ZHANG Jin-bo",
                "org": "The First Affiliated Hospital of Wenzhou Medical College,Wenzhou ,Zhejiang,China"
            },
            {
                "name": "PAN Jing-ye",
                "org": "The First Affiliated Hospital of Wenzhou Medical College,Wenzhou ,Zhejiang,China"
            },
            {
                "name": "ZHANG Xiao-le",
                "org": "Luannan Hospital,Luannan ,Hebei,China"
            },
            {
                "name": "LI Zhi-qiang",
                "org": "The First Affiliated Hospital of Wenzhou Medical College,Wenzhou ,Zhejiang,China"
            },
            {
                "name": "CHEN Jie",
                "org": "The First Affiliated Hospital of Wenzhou Medical College,Wenzhou ,Zhejiang,China"
            },
            {
                "name": "SHEN Ye",
                "org": "The First Affiliated Hospital of Wenzhou Medical College,Wenzhou ,Zhejiang,China"
            },
            {
                "name": "WU Shuang-hua",
                "org": "The First Affiliated Hospital of Wenzhou Medical College,Wenzhou ,Zhejiang,China"
            }
        ],
        "venue": "Chinese Archives of Traditional Chinese Medicine",
        "year": 2009
    },
    "Hwut0WZS": {
        "id": "Hwut0WZS",
        "title": "LncRNA LINC01512 Promotes the Progression and Enhances Oncogenic Ability of Lung Adenocarcinoma.",
        "abstract": "Previously, a significantly upregulated lncRNA, LINC01512, in lung adenocarcinoma (LAD) was obtained, while its biological function and molecular mechanisms were unclear. The expression level of LINC01512 was estimated by qPCR from 100 pairs of LAD and NT samples. The correlation of LINC01512 to clinical data of LAD patients was analyzed. LINC01512 was knocked down and overexpressed in SPCA-1 and A549 cell lines by lentivirus-mediated technology, and the oncological behavioral changes of SPCA-1 and A549 cells were observed, as well as, tumorigenicity in experimental nude mice. Compared to the adjacent tissues, LINC01512 was obviously upregulated in LAD. The expression level of LINC01512 was closely related to lymph node metastasis and tumor node metastasis (TNM) stage. Survival analysis showed that the survival time of high expression LINC01512 group was significantly shorter than the low-expression group in LAD. Knockdown or overexpression test unanimously confirmed that LINC01512 can increase the ability of cell migration, invasion, proliferation, colony formation, adhesion, and S phase and G2/M phase cells, whereas decrease the apoptosis and G0/G1 phase cells. Nude mice experiments confirmed that LINC01512 significantly enhanced the speed and weight of tumorigenicity. LINC01512 is an oncogenic lncRNA gene that promotes the progression and distinctly enhances the oncogenic ability in lung adenocarcinoma. J. Cell. Biochem. 118: 3102-3110, 2017. \u00a9 2017 The Authors. Journal of Cellular Biochemistry Published by Wiley Periodicals Inc.",
        "keywords": [
            "BIOLOGICAL FUNCTIONS",
            "LINC01512",
            "LONG NONCODING RNA",
            "LUNG ADENOCARCINOMA"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Department of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Fan Zhang",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Junjun Wang",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Lijuan Hu",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Jian Chen",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Gang Xu",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Yumin Wang",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            }
        ],
        "venue": "Journal of cellular biochemistry",
        "year": 2017
    },
    "qdtaS7qG": {
        "id": "qdtaS7qG",
        "title": "Aberrant Long Noncoding RNAs Expression Profiles Affect Cisplatin Resistance in Lung Adenocarcinoma.",
        "abstract": "We obtained patterns of irregular lncRNAs and they may play a key role in cisplatin resistance of LAD.",
        "keywords": "",
        "authors": [
            {
                "name": "Lijuan Hu",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China."
            },
            {
                "name": "Jian Chen",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China."
            },
            {
                "name": "Fan Zhang",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China."
            },
            {
                "name": "Junjun Wang",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China."
            },
            {
                "name": "Jingye Pan",
                "org": "Department of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China."
            },
            {
                "name": "Yumin Wang",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China."
            }
        ],
        "venue": "BioMed research international",
        "year": 2017
    },
    "y2X64xcK": {
        "id": "y2X64xcK",
        "title": "Long noncoding RNA expression profiles of lung adenocarcinoma ascertained by microarray analysis.",
        "abstract": "Long noncoding RNAs (lncRNAs) have been shown to be involved in the development and progression of lung cancer. However, the roles of lncRNAs in lung cancer are not well understood.We used a high-throughput microarray to compare the lncRNA and messenger RNA (mRNA) expression profiles in lung adenocarcinoma and normal tissue (NT) samples. Several candidate adenocarcinoma-associated lncRNAs were verified by real-time quantitative reverse transcription polymerase chain reaction (PCR) analysis. Using abundant and varied probes, we were able to assess 30,586 lncRNAs and 26,109 mRNAs in our microarray. We found that 2,420 lncRNAs and 1,109 mRNAs were differentially expressed (\u22652-fold change) in lung adenocarcinoma samples and NT, indicating that many lncRNAs were significantly upregulated or downregulated in lung adenocarcinoma. We also found, via quantitative PCR, that 19 lncRNAs were aberrantly expressed in lung adenocarcinoma compared with matched histologically normal lung tissues. Among these, LOC100132354 and RPLP0P2 were the most aberrantly expressed lncRNAs, as estimated by quantitative PCR in 100 pairs of lung adenocarcinoma and NT samples.Our study ascertained the expression patterns of lncRNAs in lung adenocarcinoma by microarray. The results revealed that many lncRNAs were differentially expressed in lung adenocarcinoma tissues and NT, suggesting that they may play a key role in tumor development.",
        "keywords": [
            "bioinformatics",
            "biomedical research"
        ],
        "authors": [
            {
                "name": "Gang Xu",
                "org": "Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Intensive Care Unit, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Qinshi Pan",
                "org": "Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Keta Huang",
                "org": "Department of Pathology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Jingye Pan",
                "org": "Department of Intensive Care Unit, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Wenhui Zhang",
                "org": "Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Jian Chen",
                "org": "Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Fangyou Yu",
                "org": "Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Tieli Zhou",
                "org": "Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Yumin Wang",
                "org": "Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            }
        ],
        "venue": "PloS one",
        "year": 2014
    },
    "YJgesoTw": {
        "id": "YJgesoTw",
        "title": "Analysis of human papillomavirus 16 E6/E7 gene mutation cervical cancer",
        "abstract": "Objective To investigate of E6/E7 gene variation of human papillomavirus(HPV)16 infection in women with uterine cervical cancer for epidemiological data of HPV prevention.Methods HPV16 positive samples were selected from a large number of samples,and then randomly selected cervical cell samples from100 cases of cervical cancer patients,50 cases of cervical dysplasia patients,30 cases of cervical inflammation and amplified HPV16 E6/E7 gene by PCR,then reaction products obtained gene sequences with DNA sequencing and found the variable sites by BLAST analysis in the GeneBank.Results The rate of E6 nucleotide variation in cervical cancer patients was 82.00%(82/100),significantly higher than that of cervical dysplasia,cervicitis.The most frequent HPV16 E6sequence variation was T178G(60/100);other common variation as T350G,C335T/A442C,T178G/G39T,young cervical cancer group E6 nucleotide mutation rate was no significant difference to that of non-young cervical cancer,but the T178G mutation rate significantly different.The HPV16 E7 nucleotide variation rate patients with cervical was 74.00%(74/100),that was significantly higher than cervical dysplasia,cervicitis;the most frequent sequence variation in the E7 was A647G 32.00%(32/100).Other common variations for A647G/C749T/T843C/T846C,A647G/C749T/T846C,C749T/C790T,A647G/C749T;E7 nucleotide variation rate of the young cervical cancer group was no significantly higher than non-young cervical cancer,but A647G mutation rate wassignificantly differencent.Conclusions It clearly exists of HPV16 E6 E7 nucleotide variation from cervical cancer patient in Wenzhou City and HPV E6 T178G,the E7 A647G may be closely associated with younger cervical cancer,so it was important to detect the population and take timely measures.",
        "keywords": [
            "E6/E7",
            "human papillomavirus",
            "gene variation",
            "cervical cancer"
        ],
        "authors": [
            {
                "name": "WANG Yu-min",
                "org": ".Center for Clinical Laboratory,the First Affiliated Hospital,Wenzhou Medical College,Wenzhou ,China"
            },
            {
                "name": "ZHANG Wen-hui",
                "org": ".Center for Clinical Laboratory,the First Affiliated Hospital,Wenzhou Medical College,Wenzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": ".Center for Clinical Laboratory,the First Affiliated Hospital,Wenzhou Medical College,Wenzhou ,China"
            },
            {
                "name": "DING Hong-yan",
                "org": ".Center for Clinical Laboratory,the First Affiliated Hospital,Wenzhou Medical College,Wenzhou ,China"
            },
            {
                "name": "HONG Wan-dong",
                "org": ".Center for Clinical Laboratory,the First Affiliated Hospital,Wenzhou Medical College,Wenzhou ,China"
            },
            {
                "name": "ZHU Hai-yan",
                "org": ".Center for Clinical Laboratory,the First Affiliated Hospital,Wenzhou Medical College,Wenzhou ,China"
            },
            {
                "name": "LIN Xiao-mei",
                "org": ".Center for Clinical Laboratory,the First Affiliated Hospital,Wenzhou Medical College,Wenzhou ,China"
            },
            {
                "name": "WEN Xiu-shu",
                "org": ".Center for Clinical Laboratory,the First Affiliated Hospital,Wenzhou Medical College,Wenzhou ,China"
            }
        ],
        "venue": "Modern Practical Medicine",
        "year": 2012
    },
    "ulaLyfM5": {
        "id": "ulaLyfM5",
        "title": "Low expression lncRNA RPLP0P2 is associated with poor prognosis and decreased cell proliferation and adhesion ability in lung adenocarcinoma.",
        "abstract": "We investigated the clinical roles and biological function of long non-coding (lncRNA) RPLP0P2 in lung adenocarcinoma\u00a0(LAD). The expression level of RPLP0P2 was estimated by quantitative reverse transcription-polymerase chain reaction\u00a0(qPCR) in 57\u00a0pairs of LAD and NT samples and the relation of RPLP0P2 to clinical data of LAD patients was analyzed. We overexpressed RPLP0P2 based on the human LAD cell line A549 by lentivirus\u2011mediated technology, then oncological behavior change was observed of A549 cells and the change of mRNA level of LRRC10B and RPLP0P2 by qPCR. We found that RPLP0P2 expression was lower while LRRC10B mRNA level was higher in LAD than NT by qPCR. RPLP0P2 expression level was negative correlated to LRRC10B mRNA level (Pearson correlation\u00a0=\u20110.754, P=0.0021). The expression of RPLP0P2 in lymph node metastasis of LAD group was significantly lower than LAD without lymph node metastasis group. Survival analysis showed that survival time of high expression of RPLP0P2 was significantly longer than low RPLP0P2 level in LAD patients. After RPLP0P2 was overexpressed, the proliferation rate, adhesion ability, S\u00a0phase and G2/M phase cells and LRRC10B mRNA significantly reduced, while apoptosis and G0/G1 phase cells obviously increased, but migration ability and invasion did not significantly change. Our study ascertained that low expression of RPLP0P2 in LAD is associated with poor prognosis and decreased proliferation and adhesion ability of tumor cells. LRRC10B may be a downstream gene regulated by RPLP0P2. ",
        "keywords": "",
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Department of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China."
            },
            {
                "name": "Lijuan Hu",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China."
            },
            {
                "name": "Jian Chen",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China."
            },
            {
                "name": "Fang Wu",
                "org": "Department of Digestive Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China."
            },
            {
                "name": "Dongwei Hu",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China."
            },
            {
                "name": "Gang Xu",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China."
            },
            {
                "name": "Peiwu Zhu",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China."
            },
            {
                "name": "Yumin Wang",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China."
            }
        ],
        "venue": "Oncology reports",
        "year": 2016
    },
    "ydjFhjsh": {
        "id": "ydjFhjsh",
        "title": "Detection and Analysis of Wnt Pathway Related lncRNAs Expression Profile in Lung Adenocarcinoma.",
        "abstract": "Studies have shown that the expression profile of Wnt signaling pathway is very important in lung adenocarcinoma (LAD) and some lncRNAs can regulate the expression of key molecules of Wnt pathway. However, Wnt pathway related lncRNAs are not systematically analyzed and detected in lung adenocarcinoma. We used a high-throughput microarray to compare the lncRNA expression profiles in LAD and corresponding normal tissue (NT) samples. Several candidate Wnt pathway related lncRNAs were verified by real-time quantitative reverse transcription polymerase chain reaction (PCR) analysis. We found that 232 Wnt pathway related lncRNAs were obviously expressed (\u22652-fold change) in lung adenocarcinoma samples and 13 Wnt pathway related lncRNAs were aberrantly expressed in lung adenocarcinoma compared with matched histologically normal lung tissues by qPCR. Among these, RP11-181G12.2 and RP11-89\u00a0K21.1 were the most aberrantly expressed lncRNAs. Our study ascertained the expression of Wnt pathway related lncRNAs in lung adenocarcinoma. The results revealed that many Wnt pathway related lncRNAs were differentially expressed in lung adenocarcinoma tissues, suggesting that they may play a key role in tumor development. ",
        "keywords": [
            "Expression profile",
            "LncRNAs",
            "Lung adenocarcinoma",
            "Wnt pathway"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Department of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Lijuan Hu",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, People's Republic of China."
            },
            {
                "name": "Jian Chen",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, People's Republic of China."
            },
            {
                "name": "Qinshi Pan",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, People's Republic of China."
            },
            {
                "name": "Hongyan Ding",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, People's Republic of China."
            },
            {
                "name": "Gang Xu",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, People's Republic of China."
            },
            {
                "name": "Peiwu Zhu",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, People's Republic of China."
            },
            {
                "name": "Xiusu Wen",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, People's Republic of China."
            },
            {
                "name": "Keta Huang",
                "org": "Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Yumin Wang",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, People's Republic of China. wym0577@163.com."
            }
        ],
        "venue": "Pathology oncology research : POR",
        "year": 2016
    },
    "5Nhc8rDk": {
        "id": "5Nhc8rDk",
        "title": "Downregulation of carbonic anhydrase IV contributes to promotion of cell proliferation and is associated with poor prognosis in non-small cell lung cancer.",
        "abstract": "The present study aimed to unveil the biological role of carbonic anhydrase IV (CA IV) and its association with clinical pathological characteristics and prognostic significance in non-small cell lung cancer (NSCLC). The relative expression level of CA IV was measured by reverse transcription-quantitative polymerase chain reaction in 114 resected NSCLC tumors and matched adjacent normal tissues and NSCLC cell lines. Overexpression and cell proliferation were assessed in human NSCLC cell lines transfected with CA IV mRNA by lentivirus-mediated technology. The association of CA IV expression with clinical pathological features and overall survival in 114 cases of NSCLC patients was analyzed. It was demonstrated that CA IV expression was significantly downregulated in NSCLC tumors and six cell lines. Reduced expression of CA IV was significantly correlated with lymph node metastasis. The overall survival of NSCLC patients with low CA IV expression was significantly shorter compared with the high expression group. Overexpression of CA IV suppressed cell proliferation in A549 and NCI-H1299 cells. The results indicate that low expression of CA IV promotes cell proliferation and serves as an indicator for poor prognosis in NSCLC.",
        "keywords": [
            "carbonic anhydrase IV",
            "non-small cell lung cancer",
            "prognosis",
            "proliferation"
        ],
        "authors": [
            {
                "name": "Jian Chen",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China."
            },
            {
                "name": "Lijuan Hu",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China."
            },
            {
                "name": "Fan Zhang",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China."
            },
            {
                "name": "Junjun Wang",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China."
            },
            {
                "name": "Yumin Wang",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China."
            }
        ],
        "venue": "Oncology letters",
        "year": 2017
    },
    "HAIeNBr6": {
        "id": "HAIeNBr6",
        "title": "Low Expression LncRNA TUBA4B is a Poor Predictor of Prognosis and Regulates Cell Proliferation in Non-Small Cell Lung Cancer.",
        "abstract": "We aimed to unveil the clinical roles and biological function of lncRNA TUBA4B in on-small cell lung cancer (NSCLC). The relative expression level of TUBA4B was estimated by qPCR in 114 pairs of NSCLC and NT samples and the relation of TUBA4B to clinical data of NSCLC patients was analyzed. We found TUBA4B was lower expressed in NSCLC and five cell lines. The lower expression of TUBA4B was remarkably correlated with advanced TNM stage and lymph node metastasis and served as a predictor for overall survival of NSCLC. After overexpression of TUBA4B, cell proliferation ability of A549 and NCI-H1299 remarkably decreased. Our study ascertained low expression TUBA4B in NSCLC tissue, cell lines and is a poor predictor for prognosis and can regulate cell proliferation in NSCLC.",
        "keywords": [
            "Non-small cell lung cancer",
            "Prognosis",
            "TUBA4B",
            "lncRNAs"
        ],
        "authors": [
            {
                "name": "Jian Chen",
                "org": "Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang province, People's Republic of China."
            },
            {
                "name": "Lijuan Hu",
                "org": "Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang province, People's Republic of China."
            },
            {
                "name": "Junjun Wang",
                "org": "Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang province, People's Republic of China."
            },
            {
                "name": "Fan Zhang",
                "org": "Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang province, People's Republic of China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Intensive Care Unit, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang province, People's Republic of China."
            },
            {
                "name": "Gang Xu",
                "org": "Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang province, People's Republic of China."
            },
            {
                "name": "Yumin Wang",
                "org": "Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang province, People's Republic of China. wym0577@163.com."
            },
            {
                "name": "Qinshi Pan",
                "org": "Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang province, People's Republic of China. 13957729998@163.com."
            }
        ],
        "venue": "Pathology oncology research : POR",
        "year": 2017
    },
    "XaPXssEn": {
        "id": "XaPXssEn",
        "title": "Clinical value of jointly detection pleural fluid Midkine, pleural fluid adenosine deaminase, and pleural fluid carbohydrate antigen 125 in the identification of nonsmall cell lung cancer-associated malignant pleural effusion.",
        "abstract": "Joint detection of pMK\u00a0+\u00a0pCA125\u00a0+\u00a0pADA can be used as a good indicator for the identification of MPE of NSCLC.",
        "keywords": [
            "Midkine",
            "adenosine deaminase",
            "malignant pleural effusion",
            "nonsmall cell lung cancer",
            "pleural fluid carbohydrate antigen 125"
        ],
        "authors": [
            {
                "name": "Fan Zhang",
                "org": "Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Junjun Wang",
                "org": "Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Xiaoyong Zheng",
                "org": "Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Lijuan Hu",
                "org": "Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of ICU, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Feng Jiang",
                "org": "Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Yumin Wang",
                "org": "Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            }
        ],
        "venue": "Journal of clinical laboratory analysis",
        "year": 2018
    },
    "qCFxaKpP": {
        "id": "qCFxaKpP",
        "title": "Use of an artificial neural network to predict risk factors of nosocomial infection in lung cancer patients.",
        "abstract": "Statistical methods to analyze and predict the related risk factors of nosocomial infection in lung cancer patients are various, but the results are inconsistent. A total of 609 patients with lung cancer were enrolled to allow factor comparison using Student's t-test or the Mann-Whitney test or the Chi-square test. Variables that were significantly related to the presence of nosocomial infection were selected as candidates for input into the final ANN model. The area under the receiver operating characteristic (ROC) curve (AUC) was used to evaluate the performance of the artificial neural network (ANN) model and logistic regression (LR) model. The prevalence of nosocomial infection from lung cancer in this entire study population was 20.1% (165/609), nosocomial infections occurring in sputum specimens (85.5%), followed by blood (6.73%), urine (6.0%) and pleural effusions (1.82%). It was shown that long term hospitalization (\u2265 22 days, P= 0.000), poor clinical stage (IIIb and IV stage, P=0.002), older age (\u2265 61 year old, P=0.023), and use the hormones were linked to nosocomial infection and the ANN model consisted of these four factors .The artificial neural network model with variables consisting of age, clinical stage, time of hospitalization, and use of hormones should be useful for predicting nosocomial infection in lung cancer cases.",
        "keywords": [],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China E-mail : wym0577@163.com."
            },
            {
                "name": "Qin-Shi Pan",
                "org": ""
            },
            {
                "name": "Wan-Dong Hong",
                "org": ""
            },
            {
                "name": "Jingye Pan",
                "org": ""
            },
            {
                "name": "Wen-Hui Zhang",
                "org": ""
            },
            {
                "name": "Gang Xu",
                "org": ""
            },
            {
                "name": "Yu-Min Wang",
                "org": ""
            }
        ],
        "venue": "Asian Pacific journal of cancer prevention : APJCP",
        "year": 2014
    },
    "9HQnyHZ1": {
        "id": "9HQnyHZ1",
        "title": "lncRNA LOC100132354 promotes angiogenesis through VEGFA/VEGFR2 signaling pathway in lung adenocarcinoma.",
        "abstract": "These findings suggest VEGFA was a downstream target gene of LOC100132354, promoting angiogenesis through VEGFA/VEGFR2 signaling pathway and downstream target molecules in LAD. So, LOC100132354 is considered as an antiangiogenic target in LAD.",
        "keywords": [
            "angiogenesis",
            "lncRNA",
            "lung cancer",
            "signaling pathway"
        ],
        "authors": [
            {
                "name": "Yumin Wang",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou China."
            },
            {
                "name": "Fan Zhang",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou China."
            },
            {
                "name": "Junjun Wang",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou China."
            },
            {
                "name": "Lijuan Hu",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou China."
            },
            {
                "name": "Feng Jiang",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou China."
            },
            {
                "name": "Jian Chen",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou China."
            },
            {
                "name": "Jie Chen",
                "org": "Intensive Center Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou China, chenjie991300@163.com."
            },
            {
                "name": "Liangxing Wang",
                "org": "Department of Respiratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China, wzyxywlx@163.com."
            }
        ],
        "venue": "Cancer management and research",
        "year": 2018
    },
    "ROlKDi4V": {
        "id": "ROlKDi4V",
        "title": "Clinical value of jointly detection serum lactate dehydrogenase/pleural fluid adenosine deaminase and pleural fluid carcinoembryonic antigen in the identification of malignant pleural effusion.",
        "abstract": "Joint detection of sLDH/pADA and pCEA can be used as a good indicator for the identification of benign and MPE with higher sensitivity and specificity than pCEA or sLDH/pADA.",
        "keywords": [
            "malignant pleural effusion",
            "pleural fluid carcinoembryonic antigen",
            "serum lactate dehydrogenase/pleural fluid adenosine deaminase"
        ],
        "authors": [
            {
                "name": "Fan Zhang",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Lijuan Hu",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Junjun Wang",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Jian Chen",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "Yumin Wang",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China."
            }
        ],
        "venue": "Journal of clinical laboratory analysis",
        "year": 2017
    },
    "VaP8NR5Y": {
        "id": "VaP8NR5Y",
        "title": "Laser sugery for laryngeal carcinomas",
        "abstract": "This article will review the characteristics,indications,surgical options,removal of the scope of the greatest security & efficacy of the laser surgery in laryngeal carcinomas.",
        "keywords": [
            "treatment",
            "laser sugery",
            "laryngeal carcinomas"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": " Department of Otolaryngology,Head and Neck Surgery,Renji Hospital,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "WANG Jia-dong",
                "org": " Department of Otolaryngology,Head and Neck Surgery,Renji Hospital,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Modern Oncology",
        "year": 2010
    },
    "liHEcCCQ": {
        "id": "liHEcCCQ",
        "title": "Establishment of a 5-fluorouracil-resistance laryngeal cancer cell line and its biology characteristics",
        "abstract": "Objective:To establish a multidrug resistance cell line from human laryngeal cancer cells by 5-fluorouracil(5-Fu),and provide a research model of drug resistance mechanisms of laryngeal cancer.Methods: A multidrug resistance cell line from human laryngeal Hep-2 cancer cells(Hep-2/5-FU) was established by a high dosage intermittent increase gradient method.The morphology and cell doubling time of Hep-2 and Hep-2/5-FU cells was compared;the IC50 and drug resistance fold was detected by MTT assay;the cell cycle distribution and rhodamine accumulation in Hep-2 and Hep-2/5-Fu cells was studied by flow cytometry;and the MDR1 mRNA and the corresponding MDR1-P protein expressions were detected by real-time quantitative RT-PCR or Western blotting.Results: Hep-2/5-Fu cells was established,which had a stable resistance to 5-Fu;Hep-2/5-Fu cells exhibited cross resistance to chemotherapeutic agents like cisplatin and vincristine,and its doubling time was prolonged as compared with Hep-2 cells([31.25\u00b14.37] h vs [25.62\u00b13.53] h,P<0.05).The proportion of cells in G0/G1 phase was increased([45.6\u00b13.4]% vs [30.5\u00b11.2]%,P<0.05),while decreased in S phase([32.1\u00b14.2]% vs [52.4\u00b13.6]%,P<0.05) in Hep-2/5-Fu cells as compared with those in Hep-2 cells;rhodamine accumulation in Hep-2 cells was much higher than that in Hep-2/5-Fu cells([89.83\u00b10.52]% vs [14.38\u00b10.48]%,P<0.01);and the expressions of MDR1 mRNA([13.69\u00b11.12] vs [17.82\u00b10.61],P<0.05) and the corresponding MDR1-P protein were increased in Hep-2/5-Fu cells than those in Hep-2 cells.Conclusion: The Hep-2/5-Fu cell line shows the typical and stable multidrug resistance,and may serve as a research model of laryngeal cancer resistance mechanism.",
        "keywords": [
            "drug resistance cell line",
            "laryngeal cancer",
            "MDR1",
            "5-fluorouracil"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "(Institution of Otorhinolaryngology,Department of Otolaryngology,Affiliated Renji Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai ,China)"
            },
            {
                "name": "WANG Jia-dong",
                "org": "(Institution of Otorhinolaryngology,Department of Otolaryngology,Affiliated Renji Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai ,China)"
            }
        ],
        "venue": "Chinese Journal of Cancer Biotherapy",
        "year": 2012
    },
    "2iqrpW5A": {
        "id": "2iqrpW5A",
        "title": "Effect of interferon-gamma on the expression of vascular endothelial growth factor C on Hep-2 laryngeal carcinoma cell lines]",
        "abstract": "To observe the effect of interferon-gamma on the expression of vascular endothelial growth factor C on Hep-2 laryngeal carcinoma cell lines.Hep-2 cell was exposed to interferon-gamma at a concentration (10(3), 10(4), 10(5), 10(6), 10(7) U/L) for 0, 12, 24, 36, 48, 60, 72 h hours. MTT colorimetric assay was used to evaluate the effect of interferon-gamma on Hep-2 cell proliferation after incubation with interferon-gamma. Hep-2 cell was harvested to be detected VEGF-C mRNA levels by realtime polymerase chain reaction (Realtime-PCR) with interferon-gamma (10(6) U/L) for 0, 2, 6, 12, 24, 36, 48, 60, 72 h hours. The VEGF-C protein level in supernatants was determined by enzyme-linked immunosorbent assay (ELISA) and in cytoplasma by immunocytochemical staining and Western blot analysis with the same drug treatment as Realtime-PCR.Hep-2 cell was significantly inhibited by IFN-gamma at high concentration. Expression of VEGF-C mRNA and protein levels of Hep-2 cell at 10(6) U/L concentrations of interferon-gamma were lower than that of normal control (P < 0.05) at 48 h.IFN-gamma can inhibit the expression of VEGF-C in Hep-2 cell with the level of mRNA and protein.",
        "keywords": [
            "interferon-gamma",
            "vascular endothelial growth factor c",
            "laryngeal neoplasm"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Department of Otolaryngology-Head and Neck Surgery,Renji Hospital,Shanghai Jiaotong University,Shanghai,,China"
            },
            {
                "name": "ZHOU Jia-qing",
                "org": "Department of Otolaryngology-Head and Neck Surgery,Renji Hospital,Shanghai Jiaotong University,Shanghai,,China"
            },
            {
                "name": "WANG Jia-dong",
                "org": "Department of Otolaryngology-Head and Neck Surgery,Renji Hospital,Shanghai Jiaotong University,Shanghai,,China"
            }
        ],
        "venue": "Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery",
        "year": 2008
    },
    "rStu3X7n": {
        "id": "rStu3X7n",
        "title": "Establishment of a human laryngeal carcinoma Hep-2/5-Fu cell line and the screening of differentially expressed genes]",
        "abstract": "To establish a Hep-2/5-Fu of human drug-resistant laryngeal carcinoma cell line, and to screen the possible drug resistance-associated genes.Hep-2/5-Fu of a human drug resistant laryngeal carcinoma cell line was induced by continuously exposing human laryngeal carcinoma cells to gradually increasing concentrations of 5-Fu. The growth law was observed and the growth curve was protracted. The drug resistance of Hep-2/5-Fu was measured by MTT assay and the drug resistant index RI was calculated. Genes expressed differentially between Hep-2/5-Fu and its parent cell line Hep-2 were screened using a gene chip, and several selected drug resistance associated genes were confirmed by reverse transcription-polymerase chain reaction (RT-PCR).Compared with its parental cells, the drug resistance cell line had slower growth rate and larger size. The Hep-2/5-Fu cell line showed cross drug resistance to 5-Fu, cisplatin and vincristine. There were 1210 differentially expressed genes possibly associated with drug resistance by the gene chip screening method. The possible drug resistance-related genes included Cyclin D, IGF-BP3, CASP9, and CDK4/6. The expression of Cyclin D in the Hep-2/5-Fu cell line was 6.5997 times of that in the parent cell line. RT-PCR results were consistent with the gene chip results.The altered biological properties of Hep-2/5-Fu may be related to its drug resistance phenotype. Several genes, such as Cyclin D, are possibly involved in the mechanism of drug resistance in this cell line.",
        "keywords": [
            "drug resistanee related genes",
            "hep-2/5-fu cell lines",
            "laryngeal neoplasms",
            "mtt assay",
            "5-fluorouracil",
            "reverse transcription polymerase chain reaction",
            "gene chip"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Department of Otolaryngology Head and Neck Surgery,Renji Hospital of Shanghai JiaoTong University School of Medicine,Institution of Otorhinolaryngology of Shanghai JiaoTong University,Shanghai,,China"
            },
            {
                "name": "Jiadong Wang",
                "org": "Department of Otolaryngology Head and Neck Surgery,Renji Hospital of Shanghai JiaoTong University School of Medicine,Institution of Otorhinolaryngology of Shanghai JiaoTong University,Shanghai,,China"
            }
        ],
        "venue": "Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery",
        "year": 2012
    },
    "8fhRgnlE": {
        "id": "8fhRgnlE",
        "title": "Basic fibroblast growth factor and head and neck carcinomas",
        "abstract": "Basic fibroblast growth factor is crucial for tumor growth and metastasis.This topic will review the constructions,biological functions,signal transductions,tumor angiogenesis and expressions in head and neck carcinomas of bFGF in recent years.",
        "keywords": [
            "head and neck carcinomas",
            "basic fibroblast growth factor(bFGF)"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": " Department of Otolaryngology,Head and Neck Surgery,Renji Hospital,Shanghai Jiaotong University,Shanghai,,China"
            },
            {
                "name": "ZHOU Jia-qing",
                "org": " Department of Otolaryngology,Head and Neck Surgery,Renji Hospital,Shanghai Jiaotong University,Shanghai,,China"
            },
            {
                "name": "WANG Jia-dong",
                "org": " Department of Otolaryngology,Head and Neck Surgery,Renji Hospital,Shanghai Jiaotong University,Shanghai,,China"
            }
        ],
        "venue": "Journal of Modern Oncology",
        "year": 2007
    },
    "oKPbjC2D": {
        "id": "oKPbjC2D",
        "title": "The Study of the Fuzzy Synthetical Judgement in the Hydraulic Breakdown of Non-excavate Robot",
        "abstract": "In most cases,the judgement and process of the hydraulic system breakdown is based on human's experience.Applying the fuzzy synthetical method,the diagnosis of the hydraulic system breakdown was made,which reaches the goal successfully on its first process.",
        "keywords": [
            "Fuzzy synthetical judgement diagnose",
            "Hydraulic system breakdown"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Distance Learning School,Suzhou Vocational University,Suzhou Jiangsu ,China"
            },
            {
                "name": "RUI Yannian",
                "org": "Machinery and Electronic Institute,Suzhou University,Suzhou Jiangsu ,China"
            }
        ],
        "venue": "Machine Tool & Hydraulics",
        "year": 2008
    },
    "1DjLguf4": {
        "id": "1DjLguf4",
        "title": "Research on Reliability Evaluation Method of Impact Machine of Non-excavate Robot Based on Gray Theory and Fuzzy Theory",
        "abstract": "The reliability's evaluation method of impact machine of non-excavate robot is researched by using the gray and fuzzy theory in this paper.The result shows that it is feasible to create a kind of the impact machine of non-excavate robot qualitative reliability evaluation pattern and the reliability evaluation precision is improved.",
        "keywords": [
            "impact machine",
            "fuzzy and gray theory",
            "reliablity evaluation"
        ],
        "authors": [
            {
                "name": "LI Ping",
                "org": "1.Students' affairs division,Suzhou Vocational University,Suzhou "
            },
            {
                "name": "CHEN Jie",
                "org": "2.Department of Mechanical and Electrical,Suzhou Vocational University,Suzhou ,China"
            }
        ],
        "venue": "Group Technology & Production Modernization",
        "year": 2008
    },
    "PvfHz0VC": {
        "id": "PvfHz0VC",
        "title": "Research on the Comprehensive Evaluation Method of Health State of Concrete Structure Beam Based on Fuzzy Neural Network Theory",
        "abstract": "Comprehensive evaluation and fault diagnosis are done on the health state symptom information of concrete structure beam to confirm default mode properties with fuzzy neural network theory.Satisfied results are achieved.",
        "keywords": [
            "health state",
            "concrete structure beam",
            "comprehensive evaluation",
            "fuzzy neural network theory"
        ],
        "authors": [
            {
                "name": "ZHANG Jian",
                "org": "Suzhou Broadeast and TV University,Suzhou ,China"
            },
            {
                "name": "RUI Yan-nian",
                "org": "College of Mechanical and Electrical Engineering,Soochow Univrersity,Suzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Suzhou Broadeast and TV University,Suzhou ,China"
            }
        ],
        "venue": "Journal of Soochow University(Engineering Science Edition)",
        "year": 2006
    },
    "YRhKG3l0": {
        "id": "YRhKG3l0",
        "title": "Research on design and realization of fuzzy wise information system",
        "abstract": "Under some uncertain conditions, the information offered by database often is considered as the key information when making decisions and solving problems. Fuzzy deduction method is usually used to solve practical problems as to uncertain affairs or inaccurate date. The fuzzy wise information system model described in this paper is based on database conception, fuzzy set theory and probability and distribution theory. The fuzzy logic used in the system could meet the need of information processing under uncertain condition.",
        "keywords": [
            "Fuzzy",
            "Information system",
            "Wise"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Suzhou Vocational University(Suzhou Vocational University),Suzhou,China"
            },
            {
                "name": "RUI Yan-nian",
                "org": "Soochow University(Soochow University,Suzhou University),Suzhou,China"
            },
            {
                "name": "Jian Zhang",
                "org": "Suzhou Vocational University(Suzhou Vocational University),Suzhou,China"
            }
        ],
        "venue": "Journal of Soochow University(Engineering Science Edition)",
        "year": 2006
    },
    "X6qIe346": {
        "id": "X6qIe346",
        "title": "Study on a compliant robot arm based on bionic principles with multi-degree of freedom",
        "abstract": "In this paper a new pneumatically driven compliant robot arm is designed which is based on bionic principles and has multi-degree of freedom by researching on robot hands.Dynamics model and con- trol system model are constructed by analyzing it.The theoretical base is established to be applied practically.",
        "keywords": [
            "bionic",
            "compliant control",
            "a compliant robot arm",
            "dynamics former"
        ],
        "authors": [
            {
                "name": "Chen jie",
                "org": "Distance Learning School,Suzhou Vocational University.Suzhou ,China"
            }
        ],
        "venue": "Journal of Bohai University(Natural Science Edition)",
        "year": 2007
    },
    "xsbUM0Ek": {
        "id": "xsbUM0Ek",
        "title": "Research on the Active Control Mechanism With Magnetorheological Damping Used on Horizontal Centrifuge",
        "abstract": "This paper uses the magnetorheological damping principle to solve the difficult centrifuge damping problem caused by its nonlinear vibration.The dynamic model of magnetorheological danmper has been built,the magnetorheological damper used in centrifuge is designed,and the fuzzy control principle is applied to the active control of the magnetorheological danmper,Through the computer simulation,the results are pretty good.",
        "keywords": [
            "magnetorheological",
            "the principle of fuzzy active control on damper",
            "centrifuge"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Distance Learning School,Suzhou Vocational University.Suzhou ,China"
            }
        ],
        "venue": "Machine Design & Research",
        "year": 2007
    },
    "JoWBZf3b": {
        "id": "JoWBZf3b",
        "title": "Experimental research on tensile test of B170P1 multi-gauge high strength steel laser tailor-welded blanks",
        "abstract": "Two types of B170P1 high-strength steel with different thicknesses were welded with different laser welding process parameters.The tailor-welded blanks were examined in tensile test.The mechanical property was investigated for the different laser welding parameters.The results show that the welding specimens with higher power have lower plasticity and ductility if the welding quality is eligible.Increasing the welding speed appropriately can enhance the plastic nature and ductility of welding specimens.The true stress-strain curve will be higher with the increasing heat input.It indicates that the plasticizing capacity will decrease with the increase of heat input.Small heat input can increase the plastic forming properties of tailor-welded blanks.",
        "keywords": [
            "laser tailor-welded blanks",
            "high-strength steel",
            "mechanical property",
            "tensile test",
            "welding process"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "School of Mechanical and Electrical Engineering,Suzhou Vocational University,Suzhou ,China"
            },
            {
                "name": "CHEN Wei",
                "org": "School of Mechanical Engineering,Jiangsu University,Zhenjiang ,China"
            },
            {
                "name": "XUE Lei",
                "org": "School of Mechanical Engineering,Jiangsu University,Zhenjiang ,China"
            },
            {
                "name": "CHENG Shan",
                "org": "School of Mechanical Engineering,Jiangsu University,Zhenjiang ,China"
            },
            {
                "name": "TENG Guang-yu",
                "org": "School of Mechanical Engineering,Jiangsu University,Zhenjiang ,China"
            },
            {
                "name": "WU Ming-yan",
                "org": "School of Mechanical Engineering,Jiangsu University,Zhenjiang ,China"
            }
        ],
        "venue": "Forging & Stamping Technology",
        "year": 2009
    },
    "UKd1VTBD": {
        "id": "UKd1VTBD",
        "title": "Research on the Intelligent Variable Frequency Control Method of Air-Condition Based on Genetic Algorithm and Fuzzy Theory",
        "abstract": "The popular variable frequency Air-Condition in market has the problem of lag in response and poor self-adapt.This paper uses the property of global optimization search and self-study ability of genetic algorithm,combined with the fuzzy control method,the intelligent variable frequency control method of Air-Condition based on genetic algorithm and fuzzy theory is researched.The hardware and software of control system have been designed,the simulated experiment are done on Motorala908GP32,the expected results are achieved which provides application foundation in theory and experiment.",
        "keywords": [
            "fuzzy theory",
            "genetic algorithm",
            "intelligence"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Suzhou Vocational University,Suzhou,China"
            },
            {
                "name": "RUI Yan-nian",
                "org": "Machinery and Electronic Institute,Suzhou University,Suzhou,China"
            },
            {
                "name": "ZHANG Jian",
                "org": "Suzhou Vocational University,Suzhou,China"
            }
        ],
        "venue": "Mechanical & Electrical Engineering Technology",
        "year": 2006
    },
    "fZQmrQaH": {
        "id": "fZQmrQaH",
        "title": "Rapid prototyping based on LOM and its application in developing products",
        "abstract": "The technology of rapid prototyping is one of the advanced manufacturing technologies in the late 1980s'. The technology of rapid prototyping integrates with mechanics, electronics, optics, material science etc. This article emphasizes on the basic principle and general technical process of LOM prototyping technology and uses practical examples to explain the extensive application of the technology in developing products.",
        "keywords": [
            "LOM",
            "Product-developing",
            "Rapid prototyping"
        ],
        "authors": [
            {
                "name": "Jian Zhang",
                "org": "Suzhou Vocational University(Suzhou Vocational University),Suzhou,China"
            },
            {
                "name": "Yannian Rui",
                "org": "Soochow University(Soochow University,Suzhou University),Suzhou,China"
            },
            {
                "name": "Jie Chen",
                "org": "Suzhou Vocational University(Suzhou Vocational University),Suzhou,China"
            }
        ],
        "venue": "Journal of Soochow University Engineering Science Edition",
        "year": 2008
    },
    "WRU8EBj0": {
        "id": "WRU8EBj0",
        "title": "Failure Diagnosis of Non-opening-dig Robot's Gas-moved Impulsion Mechanism based on Grey Related Theory",
        "abstract": "On the basis of traditional vibration diagnosis technology failure diagnosis system about non-opening-dig robot's gas-moved impulsion machine based on grey related theory is put forward.By the grey related degree,clustering analysis is carried out,the supervision and diagnosis on apparatus are realized.This method is simple and valuable in engineering.",
        "keywords": [
            "Grey system Clustering Failure diagnosis"
        ],
        "authors": [
            {
                "name": "Chen Jie",
                "org": ""
            },
            {
                "name": "Rui Yannian",
                "org": ""
            },
            {
                "name": "Zhang Jian",
                "org": ""
            }
        ],
        "venue": "Journal of Mechanical Transmission",
        "year": 2008
    },
    "vRnhM5Bk": {
        "id": "vRnhM5Bk",
        "title": "Research on Several Key Technologies about Automation System of Urban Track Traffic Project",
        "abstract": "With the rapid development of urban track traffic in our nation,some key technical problems on automation system of urban track traffic project need to be studied.In order to provide a few references for the advancement on automation technology of urban track traffic project in our nation,this article mainly studies several key technical problems on urban track traffic,such as synthetic supervision system,orientation technology of unmanned train,track traffic compatible with electromagnetism,reliability of track traffic system,etc.",
        "keywords": [
            "key technology",
            "automation system",
            "urban track traffic"
        ],
        "authors": [
            {
                "name": "Chen Jie",
                "org": "Suzhou Vocational university,Suzhou ,China"
            },
            {
                "name": "Rui Yannian",
                "org": "College of Mechanical and Electrical Engineering,Suzhou University,Suzhou ,China"
            },
            {
                "name": "Zhang Jian",
                "org": "Suzhou Vocational university,Suzhou ,China"
            },
            {
                "name": "Zhu Hui",
                "org": "College of Mechanical and Electrical Engineering,Suzhou University,Suzhou ,China"
            }
        ],
        "venue": "Journal of Suzhou University(Engineering Science Edition)",
        "year": 2008
    },
    "zdLfsByp": {
        "id": "zdLfsByp",
        "title": "Research on the Fuzzy Hierarchy Evaluation Method of Home Appliance Based on Green Products",
        "abstract": "According to the requirements of green products,this paper constructed the evaluation indexes system firstly after the research of home appliance;then the fuzzy hierarchy evaluation method is constructs in terms of fuzzy and uncertain properties in the process of home appliance evaluation process.Finally evaluation experiments are done on kitchen lampblack purification and satisfied results are achieved with the fuzzy hierarchy evaluation model.At the same time the practicability and feasibility of this method are proved,which provide a meaningful probe for the green evaluation of home appliance.",
        "keywords": [
            "home appliance",
            "green",
            "fuzzy hierarchy evaluation method"
        ],
        "authors": [
            {
                "name": "ZHANG Jian",
                "org": "Suzhou vocational university,Suzhou,China"
            },
            {
                "name": "RUI Yan-nian",
                "org": "machinery and electronic institute Suzhou university,Suzhou,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Suzhou vocational university,Suzhou,China"
            }
        ],
        "venue": "Mechanical & Electrical Engineering Technology",
        "year": 2006
    },
    "WexW43gH": {
        "id": "WexW43gH",
        "title": "Research on intelligent diagnosis method of the health state of equipment and structure based on piezoelectric impedance",
        "abstract": "It takes PZT intelligent material as the driving source to produce fluctuant signals, together with the artificial neural network control method, the health state of equipment and structure can be intelligently diagnosed. In the research, a kinetic model is constructed, and then the relative parameters are optimized on the basis of the experimental research of structural defect problem in engineering practice.Meanwhile, the advantages, feasibility and practicability of this method have been proved.",
        "keywords": [
            "Structural health state",
            "Intelligent diagnosis",
            "PZT"
        ],
        "authors": [
            {
                "name": "ZHANG Jian",
                "org": "Suzhou Vocational University,Suzhou ,China"
            },
            {
                "name": "RUI Yan-nian",
                "org": "Mechanical and Electronic Institute of Suzhou University,Suzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Suzhou Vocational University,Suzhou ,China"
            }
        ],
        "venue": "Machinery Design & Manufacture",
        "year": 2007
    },
    "CrpCeODm": {
        "id": "CrpCeODm",
        "title": "Research on Pattern Recognition Method of Facial Image Based on Fuzzy and Gray Theory",
        "abstract": "Facial image recognition is the most typical problem among image recognition.But there are a lot of fuzzy and gray uncertain factors among facial image recognition process.This paper researched on the fuzzy and gray theory,recognized facial image by fuzzy and gray method,which can reduce original data and guarantee and improve the precision.",
        "keywords": [
            "facial image recognition",
            "fuzzy and gray theory"
        ],
        "authors": [
            {
                "name": "ZHANG J",
                "org": ""
            },
            {
                "name": "RUI Yannian",
                "org": ""
            },
            {
                "name": "CHEN Jie",
                "org": ""
            }
        ],
        "venue": "Journal of Changchun University of Science and Technology(Natural Science Edition)",
        "year": 2007
    },
    "Ghm6n4sH": {
        "id": "Ghm6n4sH",
        "title": "Comparison between single factor design and uniform design to optimize the reaction system for RAPD of Betula luminifera",
        "abstract": "Single factor design and uniform design were used to obtain optimum scheme on reaction system for random amplified polymorphic DNA(RAPD) of Betula luminifera.And the optimum reaction systems of the two designs were compared.Results showed that both single factor design and uniform design could be used to optimize the reaction system for RAPD of B.luminifera,and single factor design caused by the effect of interaction on multifactor and could not obtain the optimum reaction system.But uniform design could avoid blindness and quickly obtained the optimum reaction system for RAPD of B.luminifera with clear bands and good stability.",
        "keywords": [
            "uniform design",
            "Betula luminifera",
            "random amplified polymorphic DNA",
            "single factor design",
            "optimization"
        ],
        "authors": [
            {
                "name": "XIE Yi-qing",
                "org": "College of the Bioengineering,Fujian Normal University,Fuzhou ,China"
            },
            {
                "name": "HUANG Ru-zhu",
                "org": "College of the Bioengineering,Fujian Normal University,Fuzhou ,China"
            },
            {
                "name": "LI Zhi-zhen",
                "org": "Fujian Academy of Forestry,Fuzhou ,China"
            },
            {
                "name": "YANG Zong-wu",
                "org": "Fujian Academy of Forestry,Fuzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Fujian Academy of Forestry,Fuzhou ,China"
            }
        ],
        "venue": "Journal of Fujian College of Forestry",
        "year": 2006
    },
    "Bm9rK0wE": {
        "id": "Bm9rK0wE",
        "title": "Information collection of Quanzhou Bay wetland based on classification method",
        "abstract": "This paper mainly used remote sensing technology to collect the Quanzhou Bay wetland information.It merged ETM+ multi-spectral image and Pan image with SFIM fusion method,PCA fusion method,Brovey fusion method and IHS fusion method,then estimated the four fusion images' quality,and selected the SFIM fusion image which was the best fusion image for the next following analysis.It classified the original ETM+ image and SFIM fusion image with Maximum Likelihood classification.The study indicated that the two images were both good in precision for collecting Quanzhou Bay information.The classification precision of SFIM fusion image was a little higher than that of original ETM+multi-spectral image,but not very obvious.This was mainly because wetland type was relatively simple;the separability among different wetland types was relatively high.",
        "keywords": [
            "information collection",
            "classification",
            "fusion",
            "Quanzhou Bay wetland",
            "remote sensing"
        ],
        "authors": [
            {
                "name": "LUO Cai-lian",
                "org": "Fujian Academy of Forestry,Fuzhou,Fujian ,China"
            },
            {
                "name": "TAN Fang-lin",
                "org": "Fujian Academy of Forestry,Fuzhou,Fujian ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Fujian Academy of Forestry,Fuzhou,Fujian ,China"
            },
            {
                "name": "LE Tong-chao",
                "org": "Fujian Academy of Forestry,Fuzhou,Fujian ,China"
            }
        ],
        "venue": "Journal of Fujian Forestry Science and Technology",
        "year": 2007
    },
    "LYLPguwP": {
        "id": "LYLPguwP",
        "title": "Community characteristics of natural forest of Cyclobalanopsis chungii on Yunzhong Mountain",
        "abstract": "The community characteristics investigation of natural forest of Cyclobalanopsis chungii on Yunzhong Mountain was taken out with contiguous grid quadrat method.The characteristics of Cyclobalanopsis chungii community,such as kinds,species diversity,population life form,frequency and age structure were studied.The results were as followed.The community had obvious stratifications,with a certain amount of interlayer plant.The Shannon-Weiner index,Simpson index and Pielou index of the layers were all showed the order of shrub layer>herbaceous layer>tree layer,while the Margalef index showed the order of herbaceous layer>shrub layer>tree layer.The number of phanerophytes was the most,and the cryptophytes and annual were not found.The frequentness showed that the main storey took up a distinct advantage in the community,which further illustrated that the forest stand renewed slowly.Besides,the age structure of the Cyclobalanopsis chungii population presented a spindle kind,which was regarded as the representation of recession population.",
        "keywords": [
            "Yunzhong Mountain",
            "Cyclobalanopsis chungii",
            "community characteristics",
            "species diversity"
        ],
        "authors": [
            {
                "name": "HUANG Yong-rong",
                "org": "College of Forestry,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China;Fujian Academy of Forestry Sciences,Fuzhou,Fujian ,China"
            },
            {
                "name": "MA Xiang-qing",
                "org": "College of Forestry,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China"
            },
            {
                "name": "YE Gong-fu",
                "org": "Fujian Academy of Forestry Sciences,Fuzhou,Fujian ,China"
            },
            {
                "name": "ZHUANG Kai",
                "org": "College of Forestry,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China;Fuzhou Beihuan Environmental Protection Technology Development Limited Company,Fuzhou,Fujian ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Fujian Academy of Forestry Sciences,Fuzhou,Fujian ,China"
            },
            {
                "name": "HUANG He",
                "org": "College of Forestry,Fujian Agriculture and Forestry University,Fuzhou,Fujian ,China"
            }
        ],
        "venue": "Journal of Fujian College of Forestry",
        "year": 2011
    },
    "OoBtUOcm": {
        "id": "OoBtUOcm",
        "title": "Analysis of Forest Resource Change Trend Based on New Collective-owned Forest Tenure Reform",
        "abstract": "Collective forest land be contracted to peasant household management,peasant household get ownership,handle right and income right of trees by collective-owned forest tenure reform,this is a great act,it will be produce an important effect to quantity and quality of forest resource.This paper takes Shaowu county of Fujian province to research object,used tenure data of forest resource planning survey shortly before and after collective-owned forest tenure reform analyse change trend on forest land areas,forest volume,rate of forest coverage,construction of area and volume of forest on the basis of type,age,dominant tree,originate and ownership of forest,and forest productive forces.The result showed that collective-owned forest fight reform is favourable to increase quantity and improve quality of forest resource.",
        "keywords": [
            "forest resource",
            "trend",
            "collective forestry property rights",
            "reform",
            "forest fight"
        ],
        "authors": [
            {
                "name": "Chen Yongfu",
                "org": " Chinese Academy of Forestry,Beijing "
            },
            {
                "name": "Chen Xingliang",
                "org": " Chinese Academy of Forestry,Beijing "
            },
            {
                "name": "Chen Qiao",
                "org": " Chinese Academy of Forestry,Beijing "
            },
            {
                "name": "Pan Hui",
                "org": " Fujian Academy of Forestry,Fuzhou "
            },
            {
                "name": "Chen Jie",
                "org": " Fujian Academy of Forestry,Fuzhou "
            },
            {
                "name": "Li Wenlin",
                "org": " Forestry Bureau of Shaowu,Shaowu "
            }
        ],
        "venue": "Forestry Economics",
        "year": 2011
    },
    "edkRhhaR": {
        "id": "edkRhhaR",
        "title": "Atmospheric Correction on Landsat ETM+ Satellite Image Based on FLAASH Model",
        "abstract": "The theory of FLAASH atmospheric correction was mainly introduced.FLAASH model was used to correct San Francisco ETM+ satellite image.Different land covers' spectral profiles and NDVI indexes were analyzed before and after FLAASH atmospheric correction.Result shows that the ETM+ satellite image can eliminate well with atmospheric effects after FLAASH model atmospheric correction.",
        "keywords": [
            "FLAASH",
            "spectral profile",
            "atmospheric correction"
        ],
        "authors": [
            {
                "name": "LUO Cai-Lian",
                "org": "Ecology Institute of Forestry Academy of Fujian Province,Fuzhou ,Fujian,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Ecology Institute of Forestry Academy of Fujian Province,Fuzhou ,Fujian,China"
            },
            {
                "name": "LE Tong-Chao",
                "org": "Ecology Institute of Forestry Academy of Fujian Province,Fuzhou ,Fujian,China"
            }
        ],
        "venue": "Protection Forest Science and Technology",
        "year": 2008
    },
    "OfAXTQFm": {
        "id": "OfAXTQFm",
        "title": "Study on the Data Process Based on Wild Animal Survey of MapObjects",
        "abstract": "Based on the technology of MapObjects and Visual Basic.Net,the record information of Fujian wild animal sampling survey data was analyzed by linear equation.In order to transform information management to GIS,the sample data that recorded the start-point and end-point coordinates were disposed by GIS.After the process,the wild animal distribution data had spatial feature and more matched the practical distribution.This method can offer a reference for the same or similar resources survey by GIS technology.",
        "keywords": [
            "MapObjects",
            "wild animal survery",
            "GIS",
            "Visual Basic.Net"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Fujian Academy of Forestry,Fuzhou,Fujian ,China"
            }
        ],
        "venue": "Journal of Fujian Forestry Science and Technology",
        "year": 2006
    },
    "6x1VJ9im": {
        "id": "6x1VJ9im",
        "title": "Effects of Different Preserved Methods for Total DNA Extraction of Betula Luminifera",
        "abstract": "Betula Luminifera, a member of \"recalcitrant plant taxa\", is such a species with high level of polyphenols, polysaccharides and other unknown secondary materials in its plant cell structures. These materials will easily make the fresh leaves of no much time for disposal formed brown-coloured products, which have a serious effect on DNA extraction. In this study, compared with fresh samples, four different storing sample methods (frozen at -20\u2103, dried with silica ge1, stored with improved saturated NaCl-CTAB solution and cell nuclear segregation buffer ) for Betula Luminifera fruit leaves were evaluated. The effects of them were compared based on the yield, purity, molecular size distribution of the extracted DNA and existence of PCR-inhibitor. Results showed that DNA could not be extracted from the frozen sample, but the quality of DNAs extracted from preserved with improved saturated NaCl-CTAB solution and cell nuclear segregation buffer was same and high comparing to fresh leaves (contro1). The molecular weight was about 48Kb and the quantity was about 400?\u6ecbg/g fresh, and produced clear polymorphiepatterns amplified by PCR. DNA also could be extracted from silica gel-dried sample though the amount was low (51.2?\u6ecbg/g) and no clear and perfect polymorphiepatterns was found.",
        "keywords": [
            "DNA extraction",
            "Polymerase chain reaction",
            "Preserved methods",
            "Betula Luminifera"
        ],
        "authors": [
            {
                "name": "Li Zhizhen",
                "org": " Fujian Academy of Forestry, Fuzhou, "
            },
            {
                "name": "Xie Yiqing",
                "org": " Fujian Academy of Forestry, Fuzhou, "
            },
            {
                "name": "Huang Ruzhu",
                "org": " The Bioengineering College of Fujian Normal University, Fuzhou, "
            },
            {
                "name": "Huang Yong",
                "org": " Fujian Academy of Forestry, Fuzhou, "
            },
            {
                "name": "Chen Jie",
                "org": " Fujian Academy of Forestry, Fuzhou, "
            }
        ],
        "venue": "Molecular Plant Breeding",
        "year": 2006
    },
    "97Lek2XO": {
        "id": "97Lek2XO",
        "title": "Application of decision tree in classifying mangrove natural reserve SPOT image",
        "abstract": "It is a good result to classify Zhangjiangkou National Mangrove Reserve SPOT image by means of decision tree and to resolve the difficulty to divide Mangrove and fruit trees by traditional supervised method.",
        "keywords": [
            "Zhangjiangkou",
            "decision tree classification",
            "Mangrove",
            "SPOT Image"
        ],
        "authors": [
            {
                "name": "LE Tong-chao",
                "org": "Fujian Academy of Forestry Sciences,Fuzhou,Fujian ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Fujian Academy of Forestry Sciences,Fuzhou,Fujian ,China"
            },
            {
                "name": "LUO Cai-lian",
                "org": "Fujian Academy of Forestry Sciences,Fuzhou,Fujian ,China"
            },
            {
                "name": "TAN Fang-lin",
                "org": "Fujian Academy of Forestry Sciences,Fuzhou,Fujian ,China"
            },
            {
                "name": "PAN Hui",
                "org": "Fujian Academy of Forestry Sciences,Fuzhou,Fujian ,China"
            }
        ],
        "venue": "Journal of Fujian Forestry Science and Technology",
        "year": 2008
    },
    "PTydC1vJ": {
        "id": "PTydC1vJ",
        "title": "The Dynamics Research of Forest Resources Based on GIS and Transfer Matrix",
        "abstract": "An experiment was conducted to analyze and evaluate the spatial dynamic changes of area,stock volume,land types,forestry and trees species and crown density during 7 years.This research was based on forest map and 2003 to 2010 resource data,with the GIS and transfer matrix supporting.The results showed that in 7 years,the studied area tended to decrease in forest area,but the stock volume was increasing.Forest land reduced by 219.20hm2,commercial forest changed significantly,the ecological forest had relative stability,tree species structure was improved,canopy density changed in a high degree,the level of forest resources management continuously improved,the business diversification trends appeared for the first time.This Studies showed that using GIS and transfer matrix technique,not only analysed the quantitative of changes in resources,but also characterized and interpreted the changing area,which improved the forest resources dynamic changes depth and level.",
        "keywords": [
            "forest resource",
            "transfer matrix",
            "dynamic change",
            "GIS"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Fujian Academy of Forestry,Fuzhou ,Fujian,China"
            }
        ],
        "venue": "Journal of Fujian Forestry Science and Technology",
        "year": 2011
    },
    "Ygi7mFl3": {
        "id": "Ygi7mFl3",
        "title": "Forecasting on the Amount of Sales of Electric Power Based on Improved Grey Model",
        "abstract": "It's important to forecasting scientifically the selling capacity for power sellers to adjust production scope and make decisions.Traditional model acts well only if original data is smooth.The paper improves smooth degree of original data sequence to increases the curiosity of model.We change to.The result implies that the change is better than other related change.The method is applied to forecast selling capacity.The result shows the curiosity of improved is distinctly increased compared with traditional.",
        "keywords": [
            "Grey forecasting model",
            "smooth degree",
            "amount of sales of electricpower",
            "improved grey forecasting model"
        ],
        "authors": [
            {
                "name": "LIU Qiu-hua",
                "org": "School of Economics and Management,Nanjing Institute of Technology,Nanjing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Economics and Management,Nanjing Institute of Technology,Nanjing ,China"
            },
            {
                "name": "GAN Hai-qing",
                "org": "Liuhe Section,Nanjing Power Supplying Company,Nanjing ,China"
            }
        ],
        "venue": "Statistics & Information Forum",
        "year": 2009
    },
    "6Fk6HOnw": {
        "id": "6Fk6HOnw",
        "title": "Research into Application of Fuzzy Real Option Theory to Power Project Evaluation",
        "abstract": "The traditional methods concerning project evaluation,for example,net present value and real option have defects,as can be seen in the particular case that supervisors have difficulties assessing accurate values.The fuzzy real option pricing model combining net present valuing and real option method is able to remove the defects and present more accurate evaluations.Based upon the analysis of the defects of classical real option method,this paper expounded on fuzzy real option pricing model theory and applied the model to power project evaluation.The results indicated that interzone of present value of prospective cash flow can be evaluated by fuzzy real option pricing model,thus providing more accurate evaluations for decision-makers.",
        "keywords": [
            "fuzzy number",
            "net present value",
            "fuzzy real options",
            "option"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "School of Economics and Management,Nanjing Institute of Technology,Nanjing ,China"
            },
            {
                "name": "LIU Qiu-hua",
                "org": "School of Economics and Management,Nanjing Institute of Technology,Nanjing ,China"
            }
        ],
        "venue": "Journal of Nanjing Institute of Technology(Natural Science Edition)",
        "year": 2008
    },
    "2Zfo9Zl3": {
        "id": "2Zfo9Zl3",
        "title": "Study on Fuzzy Recognition Model of Water Rights Pricing and Its Application",
        "abstract": "In view of the distorted price of water rights trade,according to the fuzzy set theory and the system of indices,the fuzzy recognition model for the pricing of water rights is put forward with considering the properties of quasi-market and the situation of water rights trade in China.And then the model is applied to calculate the price of water rights in Yellow River Basin in 2010 year.The results show that the model can provide theoretical basis and method for pricing of water rights trade,which is beneficial to improvement of water rights market and fully utilization of water resources.",
        "keywords": [
            "fuzzy recognition model",
            "membership function",
            "water rights pricing",
            "water rights trade",
            "water rights"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Colloge of Economics and Management,Nanjing Institute of Technology,Nanjing ,China"
            }
        ],
        "venue": "Water Resources and Power",
        "year": 2010
    },
    "bTWQV5er": {
        "id": "bTWQV5er",
        "title": "Study on Electricity Generation Forecasting in Jiangsu Province Based on Improved Gray Model",
        "abstract": "Aiming at the low prediction accuracy or not passing the test precision in the use of traditional GM(1,1),based on the data of electric generation during 2000 and 2009,improved GM(1,1)model is applied to predict electric generation in Jiangsu Province.The prediction results obtained by improved GM(1,1)are compared with traditional GM(1,1).The results show that improved GM(1,1)model significantly improves smooth degree of the original data sequence;the prediction error is much lower than the traditional GM(1,1)model.So,the electricity generation in 2015 and 2020 are predicted,which has reference significance to formulate the planning for electric power development in Jiangsu Province.",
        "keywords": [
            "electricity generation",
            "prediction",
            "improved grey prediction model",
            "Jiangsu Province"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "School of Economics and Management,Nanjing Institute of Technology,Nanjing ,China"
            },
            {
                "name": "ZHOU Yuan",
                "org": "School of Economics and Management,Nanjing Institute of Technology,Nanjing ,China"
            }
        ],
        "venue": "Water Resources and Power",
        "year": 2013
    },
    "uH96rW4Y": {
        "id": "uH96rW4Y",
        "title": "Application of Optimal Selection Weight Method to Hydropower Project Bidding",
        "abstract": "The assumption conditions of the optimal selection weight method are put forward in this paper.Based on the rule of weight optimization,the stability for weights obtained with different methods is estimated.The stability problem of selection weight is converted into nonlinear programming in optimization theory.Then the stability weight is selected.Finally,taking the hydropower projects bidding for an example,the results show that the proposed method is fit for weight stability calculation.",
        "keywords": [
            "weight",
            "quadratic optimization",
            "stability",
            "bidding",
            "linear weighted average"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "School of Economics and Management,Nanjing Institute of Technology,Nanjing ,China"
            },
            {
                "name": "XU Changxin",
                "org": "Business School,Hohai University,Nanjing ,China"
            }
        ],
        "venue": "Water Resources and Power",
        "year": 2011
    },
    "LUf9B1kX": {
        "id": "LUf9B1kX",
        "title": "Trichoderma biodiversity in China.",
        "abstract": "In the present study, we made further investigation into the diversity of Trichoderma in China than previous ones utilizing comprehensive approaches of morphological microscopic observation and phylogenetic analysis by detecting molecular markers. One thousand nine hundred ten Trichoderma strains were isolated from soil or other materials in China: East (Anhui, Fujian, Jiangsu, Jiangxi, Shandong, Zhejiang province and Shanghai municipality), South-West (Guizhou, Qinghai, Shanxi, Sichuan and Yunnan province, Tibet Autonomous Region and Chongqing municipality), South-East (Guangdong, Guangxi, Hainan province), and Middle China (Henan, Hubei and Hunan province). Representative isolates were verified at the species level by morphological characters and the oligonucleotide barcode program TrichoOKey v.10 and the custom BLAST server TrichoBLAST, using sequence of the ITS 1 and 2 region of the rDNA cluster and partial sequences of translation elongation factor 1-alpha(tef1-\u03b1). A total of 23 Trichoderma species were identified : T.asperellum, T.atrioviride, T.aureovriride, T.brevicompactum, T.citrioviride, T.erinaceum, T.gamsii, T.hamatum, T.harzianum (H.1ixii), T.intricatum, T.koningii (H.koningii), T.koningiopsis, T.longibranchiatum, T.pleuroticola, T.reeseii (H.jecorina), T.sinensis, T.spirale, T.stromaticum, T.tomentosum, T.velutinum, T.vermipilum, T.virens (H.virens), T.viride. Among them, 3 species: T.intricatum, T.stromaticum, T.vermipilum were first reported in China; T.harzianum (H,1ixii) was the most widely distributed species in China. This study further shows that, the highest biodiversity of Trichoderma population appeared in South-West China.",
        "keywords": [
            "Biogeography",
            " Molecular identification",
            " Phylogenetic analysis",
            " Trichoderma"
        ],
        "authors": [
            {
                "name": "Rui-yan Sun",
                "org": "Department of Resource and Environmental Science, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China."
            },
            {
                "name": "Zhi-cheng Liu",
                "org": "Department of Resource and Environmental Science, School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai,China"
            },
            {
                "name": "Kehe Fu",
                "org": "Department of Resource and Environmental Science, School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai,China"
            },
            {
                "name": "Lili Fan",
                "org": "Department of Resource and Environmental Science, School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai,China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Resource and Environmental Science, School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai,China"
            }
        ],
        "venue": "Journal of applied genetics",
        "year": 2012
    },
    "ivfGWuqQ": {
        "id": "ivfGWuqQ",
        "title": "Improved degradation of organophosphate dichlorvos by Trichoderma atroviride transformants generated by restriction enzyme-mediated integration (REMI).",
        "abstract": "A simple technique, REMI (restriction enzyme-mediated integration), was used to construct transformants of Trichoderma atroviride with improved capability of degrading organophosphate pesticide dichlorvos. Linearized DNA of plasmid pV2 bearing the hygromycin B phosphotransferase (hph) gene was inserted into chromosomes of wild strain T23 and transformation was confirmed by PCR and Southern blot analysis, respectively. Of 247 transformants, 76% showed improved dichlorvos degradation ability as compared to the parent strain T23 based on the least significant difference (LSD) test at p=0.01. Among them, 8 transformants exhibited 30% higher in degradation rate than the parent isolate. The highest dichlorvos degradation rate of the transformants was up to 96%. This study provided an effective approach for improving organophosphate pesticide-degrading capability of T. atroviride.",
        "keywords": [
            "dichlorvos",
            "trichoderma",
            "remi",
            "organophosphate pesticide",
            "biodegradation"
        ],
        "authors": [
            {
                "name": "Jun Tang",
                "org": "Department of Plant Science, School of Agriculture and Biology, Key laboratory of Microorganism Metabolism, Ministry of Education, Shanghai Jiaotong University, Shanghai 201101, China"
            },
            {
                "name": "Lixing Liu",
                "org": "Department of Plant Science, School of Agriculture and Biology, Key laboratory of Microorganism Metabolism, Ministry of Education, Shanghai Jiaotong University, Shanghai 201101, China"
            },
            {
                "name": "Shifeng Hu",
                "org": "College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China"
            },
            {
                "name": "Yunpeng Chen",
                "org": "Department of Plant Science, School of Agriculture and Biology, Key laboratory of Microorganism Metabolism, Ministry of Education, Shanghai Jiaotong University, Shanghai 201101, China"
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Bioresource technology",
        "year": 2009
    },
    "kcTEBTus": {
        "id": "kcTEBTus",
        "title": "Construction and functional analysis of Trichoderma harzianum mutants that modulate maize resistance to the pathogen Curvularia lunata.",
        "abstract": "Agrobacterium tumefaciens-mediated transformation (ATMT) was used to generate an insertional mutant library of the mycelial fungus Trichoderma harzianum. From a total of 450 mutants, six mutants that showed significant influence on maize resistance to C. lunata were analyzed in detail. Maize coated with these mutants was more susceptible to C. lunata compared with those coated with a wild-type (WT) strain. Similar to other fungal ATMT libraries, all six mutants were single copy integrations, which occurred preferentially in noncoding regions (except two mutants) and were frequently accompanied by the loss of border sequences. Two mutants (T66 and T312) that were linked to resistance were characterized further. Maize seeds coated with T66 and T312 were more susceptible to C. lunata than those treated with WT. Moreover, the mutants affected the resistance of maize to C. lunata by enhancing jasmonate-responsive gene expression. T66 and T312 induced maize resistance to C. lunata infection through a jasmonic acid-dependent pathway.",
        "keywords": [
            "atmt",
            "curvularia lunata",
            "trichoderma harzianum",
            "pathogen resistance"
        ],
        "authors": [
            {
                "name": "Lili Fan",
                "org": "a Department of Resource and Environmental Science, School of Agriculture and Biology , Shanghai Jiaotong University , Shanghai , China."
            },
            {
                "name": "Kehe Fu",
                "org": ""
            },
            {
                "name": "Chuanjin Yu",
                "org": ""
            },
            {
                "name": "Jia Ma",
                "org": ""
            },
            {
                "name": "Yaqian Li",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes",
        "year": 2014
    },
    "lCeVKEk3": {
        "id": "lCeVKEk3",
        "title": "Proteomics Associated with Virulence Differentiation of Curvularia lunata in Maize in China",
        "abstract": "",
        "keywords": [
            "proteomics",
            "mass spectrometry"
        ],
        "authors": [
            {
                "name": "Shufa Xu",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Lixing Liu",
                "org": ""
            },
            {
                "name": "Xiaofei Wang",
                "org": ""
            },
            {
                "name": "Xiuli Huang",
                "org": ""
            },
            {
                "name": "Yuhong Zhai",
                "org": ""
            }
        ],
        "venue": "Journal of Integrative Plant Biology",
        "year": 2007
    },
    "y1B4misn": {
        "id": "y1B4misn",
        "title": "Agrobacterium-mediated transformation as a useful tool for the molecular genetic study of the phytopathogen Curvularia lunata",
        "abstract": "In order to explore the molecular mechanisms of virulence and genetic variance of Curvularia lunata in maize, an ATMT (Agrobacterium tumefaciens-mediated transformation) system was established in order to create a wide range of insertional transformants of C. lunata. Our results showed that the germinating conidia were the ideal starting material for transformation. Based on our optimised transformation condition, the transformation efficiency of C. lunata with T-DNA was improved greatly, and the average transformation frequency was as high as 84 \u00b1 5 transformants per 1 \u00d7 106 germlings. Southern blotting results of 39 randomly-selected transformants showed a unique hybridisation pattern and predominant single-copy insertions. An ATMT library containing approximate 3000 transformants was generated, and four types of transformants were screened in terms of growth rate, sporulation, mycelial pigmentation, and toxin production in vitro. This library will be used to identify genes involved in the virulence of the pathogen. \u00a9 2009 KNPV.",
        "keywords": [
            "genetic variance",
            "germination",
            "pigmentation",
            "toxin",
            "molecular mechanics",
            "molecular genetics"
        ],
        "authors": [
            {
                "name": "Tong Liu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Lixing Liu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Xue Jiang",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Jumei Hou",
                "org": "Jindezhen Comprehensive College(Jindezhen Comprehensive College),,China"
            },
            {
                "name": "Kehe Fu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Feihong Zhou",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Jie Chen",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            }
        ],
        "venue": "European Journal of Plant Pathology",
        "year": 2010
    },
    "R2mMgY4A": {
        "id": "R2mMgY4A",
        "title": "Degradation of cyanide by Trichoderma mutants constructed by restriction enzyme mediated integration (REMI).",
        "abstract": "REMI technique was used to construct mutants with improved cyanide-degradation ability from biocontrol fungus Trichoderma koningii strain T30. The plasmid pV2 transformation was confirmed by PCR and Southern blot analysis. Out of 21 transformants, 15 single-copied transformants (71.4%) were found. To compare enzyme activities of rhodanese and cyanide hydratase, T. atroviride T23, T. harzianum T21 and their transformants constructed by REMI previously were also included. Transformants TkB6 (0.173 micromols thiocyanate formed min(-1)mg protein(-1)) from T30 and TaK1 (0.174 micromols thiocyanate formed min(-1)mg protein(-1)) from T23 showed higher rhodanese activity than other transformants and their wild strains. TkA9 (5.53 micromols formamide formed h(-1)mg protein(-1)) from T30 and Th64 (5.35 micromols formamide formed h(-1)mg protein(-1)) from T21 had higher cyanide hydratase activity than other transformants and their wild strains.",
        "keywords": [
            "cyanide hydratase",
            "trichoderma",
            "remi",
            "rhodanese",
            "cyanide degradation"
        ],
        "authors": [
            {
                "name": "Xiaoying Zhou",
                "org": "Department of Plant Science, School of Agriculture and Biology, Key Laboratory of Microbial Metabolism, Ministry of Education, Shanghai Jiaotong University, 2678 Qixin Road, Shanghai 201101, PR China"
            },
            {
                "name": "Shufa Xu",
                "org": "Department of Plant Science, School of Agriculture and Biology, Key Laboratory of Microbial Metabolism, Ministry of Education, Shanghai Jiaotong University, 2678 Qixin Road, Shanghai 201101, PR China"
            },
            {
                "name": "Lixing Liu",
                "org": "Department of Plant Science, School of Agriculture and Biology, Key Laboratory of Microbial Metabolism, Ministry of Education, Shanghai Jiaotong University, 2678 Qixin Road, Shanghai 201101, PR China"
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Bioresource technology",
        "year": 2007
    },
    "veSgKjwL": {
        "id": "veSgKjwL",
        "title": "Insertional mutagenesis and cloning of the gene required for the biosynthesis of the non-host-specific toxin in Cochliobolus lunatus that causes maize leaf spot.",
        "abstract": "The maize pathotype Cochliobolus lunatus causes Curvularia leaf spot by producing a non-host-specific toxin known as methyl 5-(hydroxymethyl) furan-2-carboxylate (M5HF2C). However, related research that explores the genes that control the production of this toxin is rare. In the current work, Agrobacterium tumefaciens-mediated transformation (ATMT) was employed to tag the gene required for the biosynthesis of the toxin. Of the 3,000 ATMT transformants recovered, 4 showed a significant decline in pathogenicity on maize leaves; 1 transformant, T806, produced no detectable M5HF2C. Genomic DNA that flanks the integrated plasmid was recovered from one of the mutants. A cosmid clone of the wild-type strain was isolated using the recovered DNA as a probe. The results of the structural and functional analyses of the region corresponding to the tagged site were then used as a basis to successfully clone one gene, called Clt-1. Bioinformatics analysis showed that the gene coded a BTB domain-containing protein that comprises 745 amino acids. Southern analysis revealed that the gene was localized in the genome as a single copy. The essential roles of Clt-1 in both toxin production and pathogenicity were confirmed by gene disruption experiments. In summary, the novel gene Clt-1 is closely associated with toxin production and pathogen virulence in leaves of susceptible varieties.",
        "keywords": [
            "melanin"
        ],
        "authors": [
            {
                "name": "Jin-Xin Gao",
                "org": ""
            },
            {
                "name": "Tong Liu",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Phytopathology",
        "year": 2014
    },
    "uLtPxmvS": {
        "id": "uLtPxmvS",
        "title": "Genome sequence and virulence variation-related transcriptome profiles of Curvularia lunata, an important maize pathogenic fungus.",
        "abstract": "Curvularia lunata is an important maize foliar fungal pathogen that distributes widely in maize growing area in China. Genome sequencing of the pathogen will provide important information for globally understanding its virulence mechanism.We report the genome sequences of a highly virulent C. lunata strain. Phylogenomic analysis indicates that C. lunata was evolved from Bipolaris maydis (Cochliobolus heterostrophus). The highly virulent strain has a high potential to evolve into other pathogenic stains based on analyses on transposases and repeat-induced point mutations. C. lunata has a smaller proportion of secreted proteins as well as B. maydis than entomopathogenic fungi. C. lunata and B. maydis have a similar proportion of protein-encoding genes highly homologous to experimentally proven pathogenic genes from pathogen-host interaction database. However, relative to B. maydis, C. lunata possesses not only many expanded protein families including MFS transporters, G-protein coupled receptors, protein kinases and proteases for transport, signal transduction or degradation, but also many contracted families including cytochrome P450, lipases, glycoside hydrolases and polyketide synthases for detoxification, hydrolysis or secondary metabolites biosynthesis, which are expected to be crucial for the fungal survival in varied stress environments. Comparative transcriptome analysis between a lowly virulent C. lunata strain and its virulence-increased variant induced by resistant host selection reveals that the virulence increase of the pathogen is related to pathways of toxin and melanin biosynthesis in stress environments, and that the two pathways probably have some overlaps.The data will facilitate a full revelation of pathogenic mechanism and a better understanding of virulence differentiation of C. lunata.",
        "keywords": [
            "virulence",
            "transcriptomes",
            "genomes",
            "transcriptomics",
            "genes",
            "signal transduction",
            "point mutation",
            "cell wall",
            "microarrays",
            "transposases",
            "genomics",
            "proteomics",
            "gene expression profiling"
        ],
        "authors": [
            {
                "name": "Shigang Gao",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai,P. R. China"
            },
            {
                "name": "Yaqian Li",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai,P. R. China"
            },
            {
                "name": "Jinxin Gao",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai,P. R. China"
            },
            {
                "name": "Yujuan Suo",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai,P. R. China"
            },
            {
                "name": "Kehe Fu",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai,P. R. China"
            },
            {
                "name": "Yingying Li",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai,P. R. China"
            },
            {
                "name": "Jie Chen",
                "org": "School of Agriculture and Biology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P, R, China. jiechen59@sjtu.edu.cn."
            }
        ],
        "venue": "BMC genomics",
        "year": 2014
    },
    "P3pbzwXq": {
        "id": "P3pbzwXq",
        "title": "Conidia immobilization of T-DNA inserted Trichoderma atroviride mutant AMT-28 with dichlorvos degradation ability and exploration of biodegradation mechanism.",
        "abstract": "An immobilizing conidia approach was used to study the degradation ability of dichlorvos in Trichoderma atroviride T-DNA insertional mutant AMT-28. Beads with 10(7) immobilized conidia per 100 mL of Na-alginate solution exhibited the highest degradation abilities. The immobilized conidia showed enhanced degradation abilities compared with immobilized or freely suspended mycelia. The immobilized cells kept good storage capacity and reusability. Dichlorvos was confirmed to be completely removed by mycelia of AMT-28 within 7 days using HPLC analysis. The dichlorvos degradation rates in auxotrophic Burk media varied and were significantly affected by nitrogen sources. There was no detectable biosorption and the removal of dichlorvos in AMT-28 was primarily attributed to a kind of Biomineralization process.",
        "keywords": [
            "biodegradation",
            "trichoderma atroviride",
            "dichlorvos",
            "immobilization"
        ],
        "authors": [
            {
                "name": "Wenliang Sun",
                "org": "Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China"
            },
            {
                "name": "Yunpeng Chen",
                "org": ""
            },
            {
                "name": "Lixing Liu",
                "org": "Department of Resources and Environmental Sciences, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China"
            },
            {
                "name": "Jun Tang",
                "org": "School of Life Science, Fuyang Normal University, Fuyang 236041, China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Resources and Environmental Sciences, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China"
            },
            {
                "name": "Peng Liu",
                "org": ""
            }
        ],
        "venue": "Bioresource technology",
        "year": 2010
    },
    "BFC2e22K": {
        "id": "BFC2e22K",
        "title": "Efficient biodegradation of cyanide and ferrocyanide by Na-alginate beads immobilized with fungal cells of Trichoderma koningii.",
        "abstract": "Cyanide or metal cyanide contaminations have become serious environmental and food-health problems. A fungal mutant of Trichoderma koningii, TkA8, constructed by restriction enzyme-mediated integration, has been verified to have a high cyanide degradation ability in our previous study. In this study, the mutant cells were entrapped in sodium-alginate (Na-alginate) immobilization beads to degrade cyanide and ferrocyanide in a liquid mineral medium. The results showed that the fungus in immobilization beads consisting of 3% Na-alginate and 3% CaCl2 could degrade cyanide more efficiently than a nonimmobilized fungal culture. For maximum degradation efficiency, the optimal ratio of Na-alginate and wet fungal biomass was 20:1 (m/m) and the initial pH was 6.5. In comparison, cell immobilization took at least 3 and 8 days earlier, respectively, to completely degrade cyanide and ferrocyanide. In addition, we showed that the immobilized beads could be easily recovered from the medium and reused for up to 5 batches without significant losses of fungal remediation abilities. The results of this study provide a promising alternative method for the large-scale remediation of soil or water systems from cyanide contamination.",
        "keywords": [
            "cyanide and ferrocyanide degradation",
            "immobilization",
            "trichoderma koningii"
        ],
        "authors": [
            {
                "name": "Xiaoying Zhou",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Lixing Liu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Yunpeng Chen",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Shufa Xu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Jie Chen",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            }
        ],
        "venue": "Canadian journal of microbiology",
        "year": 2007
    },
    "3BG7bgEF": {
        "id": "3BG7bgEF",
        "title": "Generation and identification of DNA sequence flanking T-DNA integration site of Trichoderma atroviride mutants with high dichlorvos-degrading capacity.",
        "abstract": "A protocol for efficient Agrobacterium tumefaciens-mediated transformation (ATMT) of biocontrol fungus Trichoderma atroviride strain T23 was developed to construct mutants with improved dichlorvos-degradation ability. A transformation frequency of 5x10(-6) was achieved. Among 110 genetically stable T-DNA transformants of T. atroviride T23, two transformants, AMT-12 and AMT-28, confirmed by Southern blot analysis to have single-copy inserts of T-DNA, showed an increase in dichlorvos-degradation ability of more than 10% compared to that of the wild type, exhibited similar tolerance to the pesticide, but lower spore formation ability. Five transformants exhibited a reduction in degradation of more than 70%, exhibited wild-type spore formation, and tolerated up to 800 microg/mL of dichlorvos. The left-flanking sequence of the insertion site in AMT-12 was cloned as a 1845-bp fragment and shown to have 89% identity to the DNA from T. atroviride IMI 206040; however, the involvement of this DNA in dichlorvos degradation remains still to be determined. This study can promote both a more efficient isolation of DNA sequence flanking T-DNA integration site in T. atroviride mutants and a more rational utilization of these transformants in dichlorvos degradation.",
        "keywords": [
            "atmt",
            "dichlorvos",
            "microbial degradation",
            "trichoderma atroviride"
        ],
        "authors": [
            {
                "name": "Wenliang Sun",
                "org": ""
            },
            {
                "name": "Lixing Liu",
                "org": ""
            },
            {
                "name": "Xiaolu Hu",
                "org": ""
            },
            {
                "name": "Jun Tang",
                "org": ""
            },
            {
                "name": "Peng Liu",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Yunpeng Chen",
                "org": ""
            }
        ],
        "venue": "Bioresource technology",
        "year": 2009
    },
    "TqZ0T8Z2": {
        "id": "TqZ0T8Z2",
        "title": "Understanding resistant germplasm-induced virulence variation through analysis of proteomics and suppression subtractive hybridization in a maize pathogen Curvularia lunata.",
        "abstract": "Curvularia lunata is an important pathogen causing Curvularia leaf spot in maize. Significant pathogenic variation has been found in C. lunata. To better understand the mechanism of this phenomenon, we consecutively put the selective pressures of resistant maize population on C. lunata strain WS18 (low virulence) artificially. As a result, the virulence of this strain was significantly enhanced. Using 2DE, 12 up-regulated and four down-regulated proteins were identified in virulence-increased strain compared to WS18. Our analysis revealed that melanin synthesis-related proteins (Brn1, Brn2, and scytalone dehydratase) and stress tolerance-related proteins (HSP 70) directly involved in the potential virulence growth as crucial markers or factors in C. lunata. To validate 2DE results and screen differential genes at mRNA level, we constructed a subtracted cDNA library (tester: virulence-increased strain; driver: WS18). A total of 188 unigenes were obtained this way, of which 14 were indicators for the evolution of pathogen virulence. Brn1 and hsp genes exhibited similar expression patterns corresponding to proteins detected by 2DE. Overall, our results indicated that differential proteins or genes, being involved with melanin synthesis or tolerance response to stress, could be considered as hallmarks of virulence increase in C. lunata.",
        "keywords": [
            "suppression subtractive hybridization"
        ],
        "authors": [
            {
                "name": "Shigang Gao",
                "org": "School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, PR China."
            },
            {
                "name": "Tong Liu",
                "org": ""
            },
            {
                "name": "Yingying Li",
                "org": ""
            },
            {
                "name": "Qiong Wu",
                "org": ""
            },
            {
                "name": "Kehe Fu",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Proteomics",
        "year": 2012
    },
    "2MxH5gkJ": {
        "id": "2MxH5gkJ",
        "title": "Involvement of a Polyketide Synthetase ClPKS18 in the Regulation of Vegetative Growth, Melanin and Toxin Synthesis, and Virulence in Curvularia lunata .",
        "abstract": "The clpks18 gene was first cloned and identified in Curvularia lunata. It contains 6571 base pairs (bp) and an 6276 bp open reading frame encoding 2091 amino acids. The ClPKS18 deletion mutant displayed an albino phenotype, and almost lost the ability to product 5-(hydroxymethyl) furan-2-carboxylate (M5HF2C) toxin, implying that clpks18 gene in C. lunata is not only involved in 1,8-dihydroxynaphthalene melanin synthesis, but also relatively associated with M5HF2C toxin biosynthesis of the pathogen. The pathogenicity assays revealed that \u0394ClPKS18 was impaired in colonizing the maize leaves, which corresponds to the finding that ClPKS18 controls the production of melanin and M5HF2C in C. lunata. Results indicate that ClPKS18 plays a vital role in regulating pathogenicity of in C. lunata.",
        "keywords": [
            "PKS18",
            "melanin",
            "toxin"
        ],
        "authors": [
            {
                "name": "Jin-Xin Gao",
                "org": "School of Agriculture and Biology, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai 200240, China."
            },
            {
                "name": "Jie Chen",
                "org": "School of Agriculture and Biology, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai 200240, China."
            }
        ],
        "venue": "The plant pathology journal",
        "year": 2017
    },
    "qlZj9Zxw": {
        "id": "qlZj9Zxw",
        "title": "Hex1-related transcriptome of Trichoderma atroviride reveals expression patterns of ABC transporters associated with tolerance to dichlorvos.",
        "abstract": "The tolerance to organophosphate pesticide, dichlorvos, is essential for the application of Trichoderma in bioremediation and integrated pest management, although the molecular events associated with the tolerance process have not yet been elucidated.RNA-seq analysis of wild-type Trichoderma atroviride T23 and the hex1-deleted mutant under dichlorvos stress was designed to search for genes involved in the tolerance process. A total of 5382 differentially expressed genes were identified, highlighting the complex transcriptional changes of T. atroviride in response to dichlorvos stress. 137 genes were regulated by dichlorvos and hex1, encoding major facilitator superfamilies, cytochrome P450, glutathione-S-transferase, flavoprotein, Hsp70, Hsp90, etc. Pathway and expression analysis indicated that ABC transporters were affected by the disruption of hex1 gene and might play a vital role in the tolerance process. Expression patterns of seven selected ABC transporter genes were confirmed by qRT-PCR after exposure to dichlorvos for 2, 6 and 24 h.The present study provides insights into the genetic basis of dichlorvos tolerance in Trichoderma that may be exploited for further development of bioremediation or biocontrol agents.",
        "keywords": [],
        "authors": [
            {
                "name": "Tailong Zhang",
                "org": "School of Agriculture and Biology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, People's Republic of China, ibenmoody@gmail.com."
            },
            {
                "name": "Jun Tang",
                "org": ""
            },
            {
                "name": "Jianan Sun",
                "org": ""
            },
            {
                "name": "Chuanjin Yu",
                "org": ""
            },
            {
                "name": "Zhicheng Liu",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Biotechnology letters",
        "year": 2015
    },
    "bPSf225G": {
        "id": "bPSf225G",
        "title": "Thc6 protein, isolated from Trichoderma harzianum, can induce maize defense response against Curvularia lunata.",
        "abstract": "Mutant T66 was isolated from 450 mutants (constructed with Agrobacterium tumefaciens-mediated transformation method) of Trichoderma harzianum. Maize seeds coated with T66 were more susceptible to Curvularia lunata when compared with those coated with wild-type (WT) strain. The disease index of maize treated with T66 and WT were 62.5 and 42.1%, respectively. Further research showed T-DNA has inserted into the ORF of one gene, which resulted in the functional difference between WT and T66. The gene was cloned and named Thc6, which encodes a novel 327 amino acid protein. To investigate its function, we obtained knockout, complementation, and overexpression mutants of Thc6. Challenge inoculation studies suggested that the Thc6 overexpression mutant can reduce the disease index of maize inbred line Huangzao 4 against the leaf spot pathogen (C. lunata). Meanwhile, The Thc6 mutants were found to affect the resistance of maize inbred line Huangzao 4 against C. lunata by enhancing the activation of jasmonate-responsive genes expression. Liquid chromatography-mass spectrometry (LC-MS) data further confirmed that the concentration of jasmonate in the induced maize exhibits a parallel change tendency with the expression level of defense-related genes. Hence, the Thc6 gene could be participated in the induced resistance of maize inbred line Huangzao 4 against C. lunata infection through a jasmonic acid-dependent pathway.",
        "keywords": [
            "ace2-like transcription factor thc6",
            "curvularia lunata",
            "induced resistance",
            "maize inbred line huangzao 4",
            "trichoderma harzianum"
        ],
        "authors": [
            {
                "name": "Lili Fan",
                "org": "Department of Resource and Environmental Science, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, China."
            },
            {
                "name": "Kehe Fu",
                "org": ""
            },
            {
                "name": "Chuanjin Yu",
                "org": ""
            },
            {
                "name": "Yingying Li",
                "org": ""
            },
            {
                "name": "Yaqian Li",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Journal of basic microbiology",
        "year": 2015
    },
    "Mbe9j16b": {
        "id": "Mbe9j16b",
        "title": "<i>Agrobacterium</i>-mediated transformation as a useful tool for the molecular genetic study of the phytopathogen <i>Curvularia lunata</i>",
        "abstract": "In order to explore the molecular mechanisms of virulence and genetic variance of Curvularia lunata in maize, an ATMT (Agrobacterium tumefaciens-mediated transformation) system was established in order to create a wide range of insertional transformants of C. lunata. Our results showed that the germinating conidia were the ideal starting material for transformation. Based on our optimised\n transformation condition, the transformation efficiency of C. lunata with T-DNA was improved greatly, and the average transformation frequency was as high as 84\u2009\u00b1\u20095 transformants per 1\u2009\u00d7\u2009106 germlings. Southern blotting results of 39 randomly-selected transformants showed a unique hybridisation pattern and predominant\n single-copy insertions. An ATMT library containing approximate 3000 transformants was generated, and four types of transformants\n were screened in terms of growth rate, sporulation, mycelial pigmentation, and toxin production in vitro. This library will be used to identify genes involved in the virulence of the pathogen.",
        "keywords": [
            "genetic variance.germination. pigmentation.toxin"
        ],
        "authors": [
            {
                "name": "Tong Liu",
                "org": "School of Agriculture and Biology, Shanghai Jiaotong University Department of Resources and Environmental Sciences 800 Dongchuan Road Shanghai 200240 People\u2019s Republic of China"
            },
            {
                "name": "Lixing Liu",
                "org": "School of Agriculture and Biology, Shanghai Jiaotong University Department of Resources and Environmental Sciences 800 Dongchuan Road Shanghai 200240 People\u2019s Republic of China"
            },
            {
                "name": "Xue Jiang",
                "org": "School of Agriculture and Biology, Shanghai Jiaotong University Department of Resources and Environmental Sciences 800 Dongchuan Road Shanghai 200240 People\u2019s Republic of China"
            },
            {
                "name": "Jumei Hou",
                "org": "Jindezhen Comprehensive College Department of Biology and Chemical Engineering Jiangxi 333000 People\u2019s Republic of China"
            },
            {
                "name": "Kehe Fu",
                "org": "School of Agriculture and Biology, Shanghai Jiaotong University Department of Resources and Environmental Sciences 800 Dongchuan Road Shanghai 200240 People\u2019s Republic of China"
            },
            {
                "name": "Feihong Zhou",
                "org": "School of Agriculture and Biology, Shanghai Jiaotong University Department of Resources and Environmental Sciences 800 Dongchuan Road Shanghai 200240 People\u2019s Republic of China"
            },
            {
                "name": "Jie Chen",
                "org": "School of Agriculture and Biology, Shanghai Jiaotong University Department of Resources and Environmental Sciences 800 Dongchuan Road Shanghai 200240 People\u2019s Republic of China"
            }
        ],
        "venue": "European Journal of Plant Pathology",
        "year": 2010
    },
    "DtJufiRM": {
        "id": "DtJufiRM",
        "title": "A new furanoid toxin produced by Curvularia lunata, the causal agent of maize Curvularia leaf spot",
        "abstract": "",
        "keywords": [
            "bioassay",
            "metabolites",
            "pathogen virulence",
            "pathogenicity",
            "phytotoxin",
            "relative conductivity",
            "chemical structure",
            "virulence",
            "bioassays"
        ],
        "authors": [
            {
                "name": "Tong Liu",
                "org": ""
            },
            {
                "name": "Lixing Liu",
                "org": ""
            },
            {
                "name": "Xue Jiang",
                "org": ""
            },
            {
                "name": "Xiuli Huang",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Canadian Journal of Plant Pathology-revue Canadienne De Phytopathologie",
        "year": 2009
    },
    "1brw1I4u": {
        "id": "1brw1I4u",
        "title": "Disruption of hex1 in Trichoderma atroviride leads to loss of Woronin body and decreased tolerance to dichlorvos.",
        "abstract": "The tolerance of Trichoderma species to organophosphorus pesticides is necessary for their application in the bioremediation of pesticide-polluted environments. In some cases, such a requirement is also key to the synergistic use of these fungi with chemical pesticides, aiming to broaden the scope of control targets to include both plant pathogens and insect pests. However, the mechanism of Trichoderma tolerance of organophosphorus pesticides remains unclear. To address this, we have analyzed the function of the putative dichlorvos-tolerance gene hex1 by knocking it out. The hex1-deleted mutant showed loss of Woronin bodies and decreased tolerance to the organophosphate, dichlorvos. Moreover, HEX1 localizes at the septal plugs in mycelium which may be involved in controlling intracellular movement of dichlorvos. hex1 thus is involved the tolerance to dichlorvos and the formation of Woronin bodies in Trichoderma atroviride.",
        "keywords": [],
        "authors": [
            {
                "name": "Jun Tang",
                "org": "Department of Resources and Environmental Sciences, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, 200240, People's Republic of China."
            },
            {
                "name": "YingYing Li",
                "org": ""
            },
            {
                "name": "KeHe Fu",
                "org": ""
            },
            {
                "name": "Xu Yuan",
                "org": ""
            },
            {
                "name": "ShiGang Gao",
                "org": ""
            },
            {
                "name": "Qiong Wu",
                "org": ""
            },
            {
                "name": "ChuanJin Yu",
                "org": ""
            },
            {
                "name": "WanJun Shi",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Biotechnology letters",
        "year": 2014
    },
    "qgX4T1kE": {
        "id": "qgX4T1kE",
        "title": "Proteomic analysis of Trichoderma atroviride mycelia stressed by organophosphate pesticide dichlorvos.",
        "abstract": "The proteomic approach is a powerful tool to study microbial response to environmental stress. To evaluate the responses of Trichoderma spp. to the organophosphate pesticide dichlorvos, mycelia of Trichoderma atroviride T23 were exposed to dichlorvos at concentrations of 0, 100, 300, 500, and 1000 microg/mL, respectively. Changes in protein expression were investigated using two-dimensional sodium dodecyl sulfate - polyacrylamide gel electrophoresis. Sixteen protein spots were differentially expressed. They were identified by MALDI-TOF/TOF MS and were found to be linked to energy metabolism, transport, signal transduction, and stress tolerance. Among stress-related proteins, glutathione peroxidase-like protein (GPX), 1,4-benzoquinone reductase, and HEX1 were upregulated by and cyclophilin A induced by 1000 microg/mL dichlorvos when compared with the control. These proteins were considered to be associated with fungal adaptation to adverse conditions. The results will help us to understand molecular mechanisms through which Trichoderma responds to organophosphate pesticides.",
        "keywords": [
            "2-d sds-page",
            "organophosphate pesticide stress",
            "proteomics",
            "trichoderma spp.",
            "adaptation",
            "stress response",
            "mycelium",
            "pesticides",
            "signal transduction",
            "stress",
            "sds page"
        ],
        "authors": [
            {
                "name": "Jun Tang",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Lixing Liu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Xiuli Huang",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Yingying Li",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Yunpeng Chen",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Jie Chen",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            }
        ],
        "venue": "Canadian journal of microbiology",
        "year": 2010
    },
    "RxUYxzNo": {
        "id": "RxUYxzNo",
        "title": "Biological role of Trichoderma harzianum-derived platelet-activating factor acetylhydrolase (PAF-AH) on stress response and antagonism.",
        "abstract": "We investigated the properties of platelet-activating factor acetylhydrolase (PAF-AH) derived from Trichoderma harzianum. The enzyme, comprised of 572 amino acids, shares high homology with PAF-AH proteins from T. koningii and other microbial species. The optimum enzymatic activity of PAF-AH occurred at pH 6 in the absence of Ca2+ and it localized in the cytoplasm, and we observed the upregulation of PAF-AH expression in response to carbon starvation and strong heat shock. Furthermore, PAF-AH knockout transformant growth occurred more slowly than wild type cells and over-expression strains grown in SM medium at 37\u00b0C and 42\u00b0C. In addition, PAF-AH expression significantly increased under a series of maize root induction assay. Eicosanoic acid and ergosterol levels decreased in the PAF-AH knockouts compared to wild type cells, as revealed by GC/MS analysis. We also determined stress responses mediated by PAF-AH were related to proteins HEX1, Cu/Zn superoxide dismutase, and cytochrome c. Finally, PAF-AH exhibited antagonistic activity against Rhizoctonia solani in plate confrontation assays. Our results indicate PAF-AH may play an important role in T. harzianum stress response and antagonism under diverse environmental conditions.",
        "keywords": [
            "physics",
            "protein transport",
            "engineering",
            "intracellular space",
            "biology",
            "chemistry",
            "medicine"
        ],
        "authors": [
            {
                "name": "Chuanjin Yu",
                "org": "Department of Resource and Environmental Science, School of Agriculture and Biology, Shanghai Jiao tong University, Shanghai, P. R. China; State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, P. R. China."
            },
            {
                "name": "Lili Fan",
                "org": "Department of Resource and Environmental Science, School of Agriculture and Biology, Shanghai Jiao tong University, Shanghai, P. R. China; State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, P. R. China."
            },
            {
                "name": "Qiong Wu",
                "org": "Department of Resource and Environmental Science, School of Agriculture and Biology, Shanghai Jiao tong University, Shanghai, P. R. China; State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, P. R. China."
            },
            {
                "name": "Kehe Fu",
                "org": "Department of Resource and Environmental Science, School of Agriculture and Biology, Shanghai Jiao tong University, Shanghai, P. R. China; State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, P. R. China."
            },
            {
                "name": "Shigang Gao",
                "org": "Department of Resource and Environmental Science, School of Agriculture and Biology, Shanghai Jiao tong University, Shanghai, P. R. China; State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, P. R. China."
            },
            {
                "name": "Meng Wang",
                "org": "Department of Resource and Environmental Science, School of Agriculture and Biology, Shanghai Jiao tong University, Shanghai, P. R. China; State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, P. R. China."
            },
            {
                "name": "Jinxin Gao",
                "org": "Department of Resource and Environmental Science, School of Agriculture and Biology, Shanghai Jiao tong University, Shanghai, P. R. China; State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, P. R. China."
            },
            {
                "name": "Yaqian Li",
                "org": "Department of Resource and Environmental Science, School of Agriculture and Biology, Shanghai Jiao tong University, Shanghai, P. R. China; State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, P. R. China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Resource and Environmental Science, School of Agriculture and Biology, Shanghai Jiao tong University, Shanghai, P. R. China; State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, P. R. China."
            }
        ],
        "venue": "PloS one",
        "year": 2014
    },
    "8WbmNMrG": {
        "id": "8WbmNMrG",
        "title": "Construction of transgenic Trichoderma koningi with chit42 of Metarhizium anisopliae and analysis of its activity against the Asian corn borer.",
        "abstract": "The chit42 gene was cloned from Metarhizium anisopliae CY1 and was inserted into Trichoderma koningii T30 genome by protoplast transformation. Sixteen transgenic isolates were identified by polymerase chain reaction analysis. The chit42 gene was 1275 bp in length and its coded protein was approximately 42 kDa in size. Semi-quantitative RT-PCR analysis and the measurement of the chitinase activity under induced conditions were conducted. Mortality of the Asian corn borer (Ostrinia furnacalis) was used for assessing efficacy of culture filtrates and conidial suspensions of transgenic Trichoderma strains against the insect. The results indicated that the transgenic Trichoderma strain harboring chit42 gene from Metarhizium anisopliae CY1 showed significant lethal effect on the Asian corn borer larvae. Study on growth inhibition of silkworm (Bombyx mori) larvae was carried out. The transgenic Trichoderma could better hinder the growth and development of the silkworm larvae than the wild-type Trichoderma did. The inhibition to the expression of three genes associated with development and anti-stress response in the mid-gut of the Asian corn borer larvae was more significant in the transcriptional level after larvae were fed with transgenic biomass than with the wild type. Evaluation of inhibition on the growth of maize ear rot pathogens was carried out in vitro test and the transgenic strains kept antagonistic activity against Fusarium verticilloides.",
        "keywords": [
            "trichoderma",
            "ear rot",
            "the asian corn borer",
            "metarhizium anisopliae",
            "chitinase gene",
            "polymerase chain reaction",
            "wild type",
            "stress response"
        ],
        "authors": [
            {
                "name": "Ying Y Li",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Jun Tang",
                "org": "Fujian Normal University(Fujian Normal University ^),Fuzhou,China"
            },
            {
                "name": "Ke H Fu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Shi G Gao",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Qiong Wu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Jie Chen",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            }
        ],
        "venue": "Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes",
        "year": 2012
    },
    "a5mlRcaT": {
        "id": "a5mlRcaT",
        "title": "Studies on the Liquid Fermentation Conditions for Producing Chlamydospores in Trichoderma asperellum",
        "abstract": "The optimal liquid fermentation conditions on chlamydospores high production of Trichoderma asperellum ZJSX5003 were investigated by single factor fermentation parameters comparison.The results indicated that the best single-factor conditions for the production of chlamydospores in T.asperellum ZJSX5003 were as follows:high-temperature-treated soybean cake powder mixed with maize powder solution as medium,0.005 mg/mL of glycerol,0.8\u00d7105 spores/mL of inoculum concentration,50 mL liquid medium,150r/min of rotation speed,with 30 \u2103 for 2d,20 \u2103 for 2d,28 \u2103 for 4dof incubation temperature and period,and the primary pH3.0.This single-factor optimized and fermentation conditions could make Trichoderma asperellum produce chlamydospores as much as 5.82\u00d7107 spores/mL.",
        "keywords": [
            "chlamydospores",
            "fermentation in liquid",
            "Trichoderma asperellum"
        ],
        "authors": [
            {
                "name": "WU Wei-ping",
                "org": ""
            },
            {
                "name": "CHEN Jie",
                "org": ""
            },
            {
                "name": "LI Ya-qian",
                "org": ""
            },
            {
                "name": "CHEN Li-jie",
                "org": ""
            },
            {
                "name": "HU Rong-rong",
                "org": ""
            },
            {
                "name": "DUAN Yu-xi",
                "org": ""
            }
        ],
        "venue": "Journal of Shanghai Jiaotong University(Agricultural Science)",
        "year": 2013
    },
    "ryvzBLo4": {
        "id": "ryvzBLo4",
        "title": "Pathogenic Differentiation of Gray Leaf Spot Pathogen in Maize",
        "abstract": "A set of maize inbreds or cultivars were firstly screened as GLS(Cercospora zeae-maydis)pathogen differential hosts with genetic background which current cultivars shared in China,such as inbreds Shen137,78599-1,Mo17,748,C8605-2,E28,598,Va35,K12 were identified as major ones,and cultivars Shenshi29, Shenshi31,Tiedan9,Yedan13,Dan413,Danyu18,Shennong87,Dongdan54 as affiliated ones.In term of disease rank on differential host,23 GLS strains could be classified into 5 pathogenecity groups through identification at adult stage.The pathogen-grown sorghum grains were used for inoculation into plant whirl.Among pathogenecity types we detected,the pathogenicity type\u2160appeared to be highest virulence to host plants,and pathogenicity type \u2163 is weak one,pathogenicity types \u2161,\u2162 were in middle place.The pathogenicity type V so far seemed to be difficult to be evaluated in pathogenecity.The result mentioned above provided a sound basis for breeding and identifying resistant cultivars,scientifically planting resistant cultivars in growing areas as well as monitoring of pathogen differentiation.",
        "keywords": [
            "Differential host",
            "Gray leaf spot pathogen",
            "Pathogenic differentiation"
        ],
        "authors": [
            {
                "name": "WANG Gui-qing",
                "org": "College of Agronomy,Liaocheng University,Liaocheng ,China"
            },
            {
                "name": "CHEN Jie",
                "org": ""
            }
        ],
        "venue": "Acta Agriculturae Boreali-Sinica",
        "year": 2006
    },
    "RD90dDid": {
        "id": "RD90dDid",
        "title": "Maize Stalk Rot and Ear Rot in China",
        "abstract": "This review provides a broad overview of etiology,mechanism of pathogenesis and host resistance and IPM strategies involved in maize stalk rot and ear rot diseases in China.Some different viewpoints in the past are discussed in etiology of stalk rot occurring in China.The relation of both diseases is particularly eva-(luated) based on Fusarium polymorphism analysis at the level of soluble protein,serology,isozymes and DNA,which are also further analyzed in accordance with the knowledge obtained by tracing pathogen infection process within the host root and stem tissue and trapping airborne spores nearby corn plants in the field.The recent researches of both diseases are summarized in physiological and biochemical mechanism of host(resistance) and resistant genetics,as well as IPM measures centered mainly in the application of biological(control) agents are summarized.",
        "keywords": [
            "etiology",
            "maize",
            "stalk rot",
            "ear rot",
            "mechanisms of resistance[KH+5mmD]"
        ],
        "authors": [
            {
                "name": "XU Shu-fa",
                "org": "~1School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai,China"
            },
            {
                "name": "CHEN Jie",
                "org": "~1School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai,China"
            },
            {
                "name": "GAO Zeng-gui",
                "org": "~2College of Plant Protection,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "ZOU Qing-dao",
                "org": "~2College of Plant Protection,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "JI Ming-shan",
                "org": "~2College of Plant Protection,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "LIU Hai-nan",
                "org": "~2College of Plant Protection,Shenyang Agricultural University,Shenyang ,China"
            }
        ],
        "venue": "Acta Phytopathologica Sinica",
        "year": 2006
    },
    "08NGvrcH": {
        "id": "08NGvrcH",
        "title": "Accumulation of copper in Trichoderma reesei transformants, constructed with the modified Agrobacterium tumefaciens-mediated transformation technique.",
        "abstract": "A modified Agrobacterium tumefaciens-mediated transformation method was established for the construction of mutants with improved copper tolerance and accumulation capability in Trichoderma reesei. One transformant, AT01, exhibited the highest copper accumulation capability. With copper at 0.7 mM, AT01 removed 13 mg copper/g biomass (removal rate of 96%), whereas the wild-type strain removed only 6 mg copper/g biomass (removal rate of 50%). Optimal conditions were a pH of 5.0 at 28\u00b0C. The pigment change of Trichoderma mycelia was a potential indicator of copper accumulation. Electron microscopy revealed that copper was mainly accumulated in cell vacuoles.",
        "keywords": [
            "agrobacterium tumefaciens-mediated transformation",
            "copper accumulation",
            "trichoderma reesei",
            "Agrobacterium tumefaciens-mediated transformation",
            "Copper accumulation",
            "Trichoderma reesei"
        ],
        "authors": [
            {
                "name": "Kehe Fu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Lixing Liu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Lili Fan",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Tong Liu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Jie Chen",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            }
        ],
        "venue": "Biotechnology letters",
        "year": 2010
    },
    "L0JjXQUt": {
        "id": "L0JjXQUt",
        "title": "Differential proteomic analysis of proteins in S17 induced by cucumber powdery mildew fungus",
        "abstract": "Two-dimensional electrophoresis was employed to analyze proteins extracted from sterile and fungal-infected seedling leaves of cucumber S17 at 24 h,48 h and 72 h after inoculating Sphaerotheca fuliginea.Different spots corresponding to induced or repressed proteins were apparent in Coomassie Brilliant Blue G-250 stained 2-DE gels.Eight different proteins of S17 seedling leaves with qualitative changes or relatively high abundance were identified by MALDI-TOF/ TOF and blast in NCBI,including a protein of chloroplast rieske FeS protein,superoxide dismutase ,chromoplast-specific carotenoid-associated protein,translationally controlled tumor protein-related protein,heat shock protein 90,ferredoxin-NADP(H) oxidoreductase,hypothetical protein g5bf and similar to gb|D64087 nuclear matrix constituent protein 1(NMCP1) from Daucus carota.The proteins induced in response to infection were those involved in disease resistance,heat-shock protein,chromosome transcription and translation,or in protein-related photosynthesis and respiration,as well as some unkown proteins.The results provided new insights for pathogen stress response in cucumber leaves,demonstrating the power of the proteomic approach in plant biology studies.",
        "keywords": [
            "cucumber",
            "mass spectrometry",
            "two-dimensional gel electrophoresis",
            "powdery mildew",
            "enzymes",
            "heat shock proteins",
            "disease resistance",
            "proteomics",
            "leaves",
            "proteomes"
        ],
        "authors": [
            {
                "name": "FAN Hai-yan",
                "org": "College of Biological Science and technology,Shenyang Agricultural University,Shenyang ,China;School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "QU Bo",
                "org": "College of Biological Science and technology,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "SHAO Mei-ni",
                "org": "College of Biological Science and technology,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "CUI Na",
                "org": "College of Biological Science and technology,Shenyang Agricultural University,Shenyang ,China"
            }
        ],
        "venue": "Acta Phytopathologica Sinica",
        "year": 2009
    },
    "W8n5xpx1": {
        "id": "W8n5xpx1",
        "title": "Effect of calcium messenger in cucumber cells induced by glucohexaose",
        "abstract": "The study used the cucumber leaves as test materials to identify the variation of Ca2+content and Ca2+-ATPase activity.Meanwhile the effect of calmodulin distribution was measured against the immuno-gold electron microscopy to find out the effect of calcium messenger induced by glucohexaose.Results showed that the maximum content of soluble Ca2+ and total Ca2+ and proportion of conjugated calcium ion rose respectively by 12 h,by 24 h and by 144 h,while the maximum of Ca2+-ATPase activity incresed by 48 h.Calmodulin was distributed all in the nucleus,chloroplast,vacuole,intercellular space,its mitochondria as well as in the cell wall, while much calmodulin was found in the chloroplast and the cell wall in cucumber cells induced with glucohexaose.However,calmodulin distributed rarely in chloroplast and the cell wall in cucumber cells treated by water.Calcium messenger system elicited by glucohexaose possibly joined in photosynthesis,and enhanced resistance against plant disease.",
        "keywords": [
            "immuno-gold electronic microscope",
            "cucumber",
            "calcium messenger",
            "gucohexaose"
        ],
        "authors": [
            {
                "name": "SUN Yan-qiu",
                "org": "College of Plant Protection,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "LI Bao-ju",
                "org": "Institute of Vegetables and Flowers,The Chinese Academy of Agricultural Sciences,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "SHI Yan-xia",
                "org": "Institute of Vegetables and Flowers,The Chinese Academy of Agricultural Sciences,Beijing ,China"
            }
        ],
        "venue": "Journal of Agricultural University of Hebei",
        "year": 2008
    },
    "tPoLoh3V": {
        "id": "tPoLoh3V",
        "title": "Infection Process of Curvularia lunata on Corn Leaf Observed in Incompatible Interaction",
        "abstract": "Infection process of Curvularia lunata on corn leaf were observed by means of tissue transparent method.The results showed that the conidia of Curvularia lunata germinated at 2 h after inoculation.The germination percentages of conidia examined at 4 h and 6 h after inoculation were 80% and 99%,respectively.Invasive hypha penetrated epidermal cell through intercellular space and stoma between 12 h and 24 h.Invasive hypha became thin when it penetrated cell wall.Structure of stoma was destroyed and guard cells were degraded when invasion hypha pierced the stomas.Conidiophore and conidia stretched form intercellular space and stomas on 3days after inoculation.Corn leaves appeared typical symptom on 3 days after inoculation.",
        "keywords": [
            "Infection process",
            "Compatible interaction",
            "Corn",
            "Curvularia lunata"
        ],
        "authors": [
            {
                "name": "XUE Chun-sheng",
                "org": "Laboratory of Molecular and Physiological Plant Pathology of Shenyang Agricultural University,Shenyang "
            },
            {
                "name": "ZHAO Zhi-wei",
                "org": "Laboratory of Molecular and Physiological Plant Pathology of Shenyang Agricultural University,Shenyang "
            },
            {
                "name": "XIAO Shu-qin",
                "org": "Laboratory of Molecular and Physiological Plant Pathology of Shenyang Agricultural University,Shenyang "
            },
            {
                "name": "HUANG Wei-dong",
                "org": "Laboratory of Molecular and Physiological Plant Pathology of Shenyang Agricultural University,Shenyang "
            },
            {
                "name": "CAI Lei",
                "org": "Laboratory of Molecular and Physiological Plant Pathology of Shenyang Agricultural University,Shenyang "
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology of Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Maize Sciences",
        "year": 2010
    },
    "k7PsL0Yg": {
        "id": "k7PsL0Yg",
        "title": "Chemical Prevention and Treatment of Maize Southern Leaf Blight at Early Growth Season",
        "abstract": "Southern leaf blight is one of main diseases in maize growing area of China,usually occurs in the warm damp area.It reduced maize yield ranging from 15% to 20%,even caused complete loss.To control southern leaf blight caused by Bipolaris maydis at early crop growth season(at bell stage),9 chemical fungicides and 2 Trichoderma fungicides were screened through plate test,greenhouse experiment and field trials.The results showed that Trichoderma H04,thiophanate-methyl and dimethomorph-mancozeb had suppressing action on Bipolaria maydis,the inhibition ratios were 80%.They displayed significant preventing functions to maize southern blight in the greenhouse and field conditions.",
        "keywords": [
            "Trichoderma",
            "maize southern leaf blight",
            "chemical fungicide",
            "chemical control"
        ],
        "authors": [
            {
                "name": "MA Jia",
                "org": "Key Lab of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture & Biology, Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "ZHANG Ting",
                "org": "Key Lab of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture & Biology, Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "WANG Meng",
                "org": "Key Lab of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture & Biology, Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "GAO Jin-xin",
                "org": "Key Lab of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture & Biology, Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "LI Ya-qian",
                "org": "Key Lab of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture & Biology, Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Key Lab of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture & Biology, Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Shanghai Jiaotong University(Agricultural Science)",
        "year": 2013
    },
    "qxjZGv5a": {
        "id": "qxjZGv5a",
        "title": "Comparison of Antagonistic Effects of Four Trichoderma Strains",
        "abstract": "Using confrontation test,detection of volatile and non-volatile inhibitory substances and assay of chitinase activity as well as inoculation on cucumber seedlings,we compared the potential biocontrol activity of four selected Trichoderma strains.Among them,strain YZ1303 showed the strongest antagonistic activity against Fusarium oxysporum f.sp.cucumerinum in confrontation test,but the lowest chitinase activity in in-vitro detection.The non-volatile substances released from strain SH2303 exhibited the highest inhibition rate of 41.33% against pathogen growth,and the strain also had the highest control efficacy against cucumber Fusarium wilt.Comparatively,strain HF3407 was identified in vitro with higher activity of chitinase and higher production of inhibitory volatile substances,and also proven in vivo to be good in the control of cucumber Fusarium wilt.Taken together,establishment of a comprehensive evaluation system is of great importance to the highly effective screening of antagonistic Trichoderma strains.",
        "keywords": [
            "antagonistic activity",
            "Trichoderma",
            "non-volatile substance",
            "volatile substance",
            "chitinase"
        ],
        "authors": [
            {
                "name": "WANG Bingli",
                "org": "Key Laboratory of Southen Urban Agriculture,Ministry of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai "
            },
            {
                "name": "LI Guangji",
                "org": "Agricultural Technology Extension and Service Center,Shanghai ,China"
            },
            {
                "name": "GUO Yuren",
                "org": "Agricultural Technology Extension and Service Center,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Key Laboratory of Southen Urban Agriculture,Ministry of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai "
            }
        ],
        "venue": "Chinese Journal of Biological Control",
        "year": 2012
    },
    "QFz8BU9G": {
        "id": "QFz8BU9G",
        "title": "PEG-mediated protoplast transformation of Curvularia lunata,the causal agent of Curvularia leaf spot in maize",
        "abstract": "The effects of the composition of various enzymes on protoplast of Curvularia lunata preparation were explored,and its protoplast-mediated genetic transformation system was established.Protoplast was obtained through cleavage of mycelium using enzyme mixture.Protoplast genetic transformation was mediated by polyethylene glycol(PEG),and transformants were analyzed by PCR and Southern blotting.The best composition of enzymes for protoplast preparation was 1% snailase,1% cellulase and 1% wallzyme,which could produce 6.78 \u00d7 106 protoplasts/mL.Sixteen stable transformants were obtained by PEG,and the plasmid pV2 was successfully integrated into the genome in 5 randomly selected transformants.The best composition of enzymes for protoplasts preparation was obtained,and the protoplast-mediated genetic transformation system of C.lunata was established,which provided a tool for cloning pathogenicity genes and studying the gene function.",
        "keywords": [
            "Curvularia lunata",
            "wallzyme",
            "protoplast",
            "transformation"
        ],
        "authors": [
            {
                "name": "Liu Tong",
                "org": "College of Agronomy,Heilongjiang Bayi Agricultural University,Daqing ,China"
            },
            {
                "name": "Hou Jumei",
                "org": "College of Agronomy,Heilongjiang Bayi Agricultural University,Daqing ,China"
            },
            {
                "name": "Chen Jie",
                "org": "College of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "Jing Jing",
                "org": "College of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "Wang Yuying",
                "org": "College of Agronomy,Heilongjiang Bayi Agricultural University,Daqing ,China"
            },
            {
                "name": "Zuo Yuhu",
                "org": "College of Agronomy,Heilongjiang Bayi Agricultural University,Daqing ,China"
            }
        ],
        "venue": "Plant Protection",
        "year": 2012
    },
    "5veseBLq": {
        "id": "5veseBLq",
        "title": "Effect of antagonistic strain B20-006 of endophytic bacteria on major defensive enzymes in corn root",
        "abstract": "Endophytic bacteria B20-006,an antagonistic microbe,was applied to coat maize seeds and resulted in 67.9% control effect on maize sheath blight caused by Rhizoctonia solani.Moreover,B20-006 was ensured the ability to penetrate roots,and in turn move along vascular elements of maize plants.For further study of biocontrol mechanism of the antagonistic agent,the changes of major defensive enzymes(PAL,POD,SOD and EST) in specific activity were assayed in plants due to interaction between B20-006 and host maize.",
        "keywords": [
            "maize",
            "Rhizoctonia solani",
            "defensive enzymes",
            "endophytic bacteria"
        ],
        "authors": [
            {
                "name": "GAO Zeng-gui",
                "org": "College of Plant Protection,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Plant Protection,Shenyang Agricultural University,Shenyang ,China;School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "LIU Jun-hua",
                "org": "College of Plant Protection,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "FENG Jing",
                "org": "College of Plant Protection,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "ZHAO Hui",
                "org": "College of Plant Protection,Shenyang Agricultural University,Shenyang ,China"
            }
        ],
        "venue": "Acta Phytopathologica Sinica",
        "year": 2007
    },
    "UeCnWBRa": {
        "id": "UeCnWBRa",
        "title": "Cloning of Full Length cDNA of Triose Phosphate Translocator from Corn and Its Expression in Tobacco",
        "abstract": "",
        "keywords": [
            "expression",
            "tobacco",
            "triose phosphate translocator",
            "cDNA clone"
        ],
        "authors": [
            {
                "name": "XUE Chun-sheng",
                "org": " Laboratory of Molecular and Physiological Plant Pathology, Shenyang Agricultural University,Shenyang , China; State Key Laboratory of Agrobiotechnology, China Agricultural University,Beijing , China"
            },
            {
                "name": "XIAO Shu-qin",
                "org": " Laboratory of Molecular and Physiological Plant Pathology, Shenyang Agricultural University,Shenyang , China"
            },
            {
                "name": "WANG Guo-ying",
                "org": " State Key Laboratory of Agrobiotechnology, China Agricultural University,Beijing , China"
            },
            {
                "name": "CHEN Jie",
                "org": " School of Agriculture and Biology,Shanghai Jiaotong University, Shanghai , China"
            }
        ],
        "venue": "Journal of Agricultural Biotechnology",
        "year": 2008
    },
    "q0X2vz53": {
        "id": "q0X2vz53",
        "title": "Proteomic Analysis of F_2 Generation of Cucumber Against the Cucumber Powdery Mildew Disease",
        "abstract": "Proteomic approaches using two-dimensional gel electrohoresis(2-DE)were adopted to identify proteins from cucumber leaves differentially expressed in F2 generation of cucumber.Nearly 500 proteins were reproducibly detected,including 39 specific proteins expressed in F2 sensitive pool samples and 22 specific proteins expressed in resistance pool samples,35 proteins were two-fold upper limit and 46 proteins were two-fold lower limit.Analysis with MALDI-TOF-MASS showed that nine important proteins associated with defensive reaction were identified in F2 cucumber,a protein of disease resistance gene(SSP3110),14-3-3 brain protein homolog(SSP1411),coproporphyrinogen \u2162 oxidase(SSP5513),carbonic anhydrase(SSP5412),alpha-galactosid-ase-like protein(SSP5710),putative protein(SSP6002),17.8 kDa class small heat shock protein(SSP0710),hypothetical protein(SSP3111),(S)-2-hydroxy-acid oxidase(EC1.1.3.15)-cucurbit(SSP4610).All of those proteins were probably parts of network of resistance or development-related proteins.This study gives new insights into cucumber powdery mildew resistant response in cucumber leaves and demonstrates the power of the proteomic approach in plant biology studies.",
        "keywords": [
            "Two-dimensional gel electrophoresis",
            "Mass spectrometry",
            "Powdery mildew",
            "Cucumber",
            "Protein"
        ],
        "authors": [
            {
                "name": "FAN Hai-yan",
                "org": "Biological Science & Technology,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "L\u00fc Chun-mao",
                "org": "Academy of Shenyang Agriculture Science and Technology,Shenyang ,China"
            },
            {
                "name": "ZHANG Chun-yu",
                "org": "Biological Science & Technology,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "SUN Quan",
                "org": "Biological Science & Technology,Shenyang Agricultural University,Shenyang ,China"
            }
        ],
        "venue": "Acta Horticulturae Sinica",
        "year": 2007
    },
    "s1Hr2Rmj": {
        "id": "s1Hr2Rmj",
        "title": "Biological Characteristics of the Pathogen in Gladiola Dry Rot",
        "abstract": "The dry rot of gladiola,caused by Fusarium oxysporum f.sp gladioli is one of main diseases in gladioli.However,until now less work has been conducted on the biologic-characteristics of the pathogen,and leading to poor control of the diseases.The results shows that the optimal medium is amylaceum-peptone,the pathogen was able to use many kinds of carbon sources for the growth in which fructose is best,whereas malt sugar was the worst.As to the growth of the hypha,optimal nitrogen source was beef extract, whereas kalium nitricum was tfae worst;For the spore production of the pathogen,the optimal nitrogen source was yeast while amchlor, was the worst.25\uff5e28\u2103,pH 5\uff5e6 were an dptimal condition for growth of Fusarium oxyspoyum f.sp glalili,Entire dark condition bene- fited spore production.For spore germination the Optimum temperature and relative humidity (RH) were 20\uff5e28\u2103 and 90%\uff5e100%, respectively,however,spore germination is best at 28\u2103 and in drops of water.The spores failed to germinate at RH<90%.Spore germination was available in the rang of pH 4\uff5e5,but pH 10 or above inhibited spore germination.Dark condition was favorable for spore germination.",
        "keywords": [
            "dry rot",
            "biological characteristics",
            "gladiola",
            "Fusarium oxyspoyum f.sp glalili"
        ],
        "authors": [
            {
                "name": "LI Xiao-qin",
                "org": "Shanghai Jiao Tong University,Shanghai ,China;Dept of plant protection Sichuan Agriculture University,Yaan ,China"
            },
            {
                "name": "HUANG Yun",
                "org": "Shanghai Jiao Tong University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Shanghai Jiao Tong University,Shanghai ,China"
            },
            {
                "name": "LIU Li-xing",
                "org": "Shanghai Jiao Tong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Shanghai Jiaotong University(Agricultural Science)",
        "year": 2008
    },
    "2J9xqGQW": {
        "id": "2J9xqGQW",
        "title": "Defensive Enzyme in Melon Induced by Trichoderma Against Wilt",
        "abstract": "The control effect of Trichoderma against melon wilt was done in pot and in field.The changes of activities of the defence enzymes were analyzed in roots of melon seedings after inoculation with Trichoderma.The results showed that.Trichoderma could control melon wilt efficiently.Control effect in pot and in field was 72.73% and 79.00% respectively.Inoculation with Trichoderma followed by Fusarium oxysporum was able to increase the activities of phenylalanine ammonia-lysae(PAL),peroxidase(POD),prophenyloxidase(PPO).The \u03b2-1,3-glucanase was significantly greater than others.So Trichoderma could induce the resistant reaction of melon to Fusarium oxysporum.",
        "keywords": [
            "\u03b2-1",
            "PPO",
            "Trichoderma",
            "PAL",
            "Fusarium oxysporum",
            "POD",
            "3-glucanase enzyme",
            "induced resistance"
        ],
        "authors": [
            {
                "name": "HUANG Yan-qing",
                "org": "College of Plant Protection,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "ZHUANG Jing-hua",
                "org": "College of Plant Protection,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "XU Shao",
                "org": "College of Plant Protection,Yunnan Agricultural University,Yunnan "
            },
            {
                "name": "CHEN Jie",
                "org": "College of Agricultuarl and Biology Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Shenyang Agricultural University",
        "year": 2005
    },
    "uqeHwHcy": {
        "id": "uqeHwHcy",
        "title": "Identification Technique of Physiological Differentiation of Gray Leaf Spot Pathogen",
        "abstract": "This research studied the identification and inoculation methods of pathogenic differentiation of gray leaf spot(GLS) pathogen,and the effect of environmental conditions have also been considered.The results showed that the resistant identification of GLS pathogen in maize could be identified during the seedling and adult plant stage.the adult plant identification was better considering the easer inoculation.Identifying resistant identification using maize inbred was better than that of maize cultivar.The method of that,inoculate sorghum seed with inocula into leaf whorl was the preferred method for resistant,GLS was prone to occur under high-temperature and high-humidity condition.The disease couldn't infect when temperature and humidity wasn't fitting.The concentration and spatial heterogeneity of soil nutrition,especially,the content of nitrogen and phosphorus,all affect the infection ability of this disease.The high-nitrogen and high-phosphorus could improve the resistance of maize to GLS.To some extent,light intensity didn't have significant influence on the infection of GLS.",
        "keywords": [
            "Identification method",
            "Physiological differentiation",
            "Gray leaf spot pathogen"
        ],
        "authors": [
            {
                "name": "WANG Gui-qing",
                "org": "College of Agronomy,Liaocheng University,Shandong Liaocheng "
            },
            {
                "name": "CHEN Jie",
                "org": "College of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Maize Sciences",
        "year": 2006
    },
    "mrJ3hD6K": {
        "id": "mrJ3hD6K",
        "title": "The Advances of Chitinases and Their Genes from Trichoderma spp.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "HU Shi-feng",
                "org": "College of Bio-Safety Science and Technology,Hunan Agricultural University,Changsha ;College of Veterinary Medicine,HNAU"
            },
            {
                "name": "GAO Bi-da",
                "org": "College of Bio-Safety Science and Technology,Hunan Agricultural University,Changsha "
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University"
            }
        ],
        "venue": "Chinese Journal of Biological Control",
        "year": 2008
    },
    "KXAgYf5q": {
        "id": "KXAgYf5q",
        "title": "Evaluation on Screening Methods for Trichoderma spp.Antagonistic to Fusarium oxysporum",
        "abstract": "In attempt to establish an high-throughput screening method of biocontrol Trichoderma strains against Fusarium oxysporum in cucumber,authors compared selection efficiency of five screening methods,that is dual-culture method,pathogen survival measurement after treatment with antagonistic microbe,degradation of pathogen's mycelium after treatment with secretion of biocontrol microbe,seed germination recovery test after target pathogen infected by biocontrol microbe and the screening of biocontrol microbe on host seedling in the presence of pathogen.Results showed that the final screening result of each method varied among the five tested methods.However,the method based on pathogen survival measurement after Trichoderma treatment gave rise to a highly consistent result with that from the screening on inoculated living host seedlings.The authors therefore recommended the pathogen survival measurement after Trichoderma treatment as an effective approach to make the preliminary screening of biocontrol Trichoderma strains.",
        "keywords": [
            "biocontrol",
            "screening methods",
            "Fusarium oxysporum",
            "Trichoderma spp."
        ],
        "authors": [
            {
                "name": "XIONG Min",
                "org": "Biosafety Science and Technology College,Hunan Agricultural University,Changsha ;School of Agriculture and Biology,Key Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,Shanghai Jiao Tong University,Shanghai ,China"
            },
            {
                "name": "GAO Bi-da",
                "org": "Biosafety Science and Technology College,Hunan Agricultural University,Changsha "
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Key Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,Shanghai Jiao Tong University,Shanghai ,China"
            }
        ],
        "venue": "Chinese Journal of Biological Control",
        "year": 2011
    },
    "ysEmCne7": {
        "id": "ysEmCne7",
        "title": "Expression of green fluorescent protein in Curvularia lunata causing maize leaf spot",
        "abstract": "",
        "keywords": [
            "curvularia lunata",
            "genetic transformation",
            "green fluorescent protein",
            "wild type",
            "reporter gene"
        ],
        "authors": [
            {
                "name": "Tong Liu",
                "org": ""
            },
            {
                "name": "Lixing Liu",
                "org": ""
            },
            {
                "name": "Jumei Hou",
                "org": ""
            },
            {
                "name": "Guangji Li",
                "org": ""
            },
            {
                "name": "Shigang Gao",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Canadian Journal of Plant Pathology-revue Canadienne De Phytopathologie",
        "year": 2010
    },
    "N5iS2aLY": {
        "id": "N5iS2aLY",
        "title": "Inoculation Method of Gray Leaf Spot Pathogen",
        "abstract": "The gray leaf spot(GLS) is a significant leaf disease in maize.Four inoculation method including spraying,inoculate inocula into leaf whorl(inoculate inocula),inoculate sorghum seed with inocula into leaf whorl(inoculate sorghum seed) and injection have been used in this article.This research studied handy,easy and authentic artificial inoculation method of resistant identification in field.The spraying method is common inoculation technique of maize leaf disease.But the method of that,inoculate sorghum seed with inocula into leaf whorl is the first resistant identification of GLS pathogen because it is better in the heat humidity and operation.Sorghum seed with inocula was inoculated into leaf whorl of plants at 11-12 leaf stage of plant.The increased disease incidence was observed in the fields.",
        "keywords": [
            "Resistant identification",
            "Inoculation method",
            "Gray leaf spot pathogen",
            "Maize"
        ],
        "authors": [
            {
                "name": "WANG Gui-qing",
                "org": "College of Agronomy,Liaocheng University,Liaocheng ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Maize Sciences",
        "year": 2006
    },
    "WDf0npQs": {
        "id": "WDf0npQs",
        "title": "Study of Herbicidal Activity of Toxin Produced by Curvularia lunata",
        "abstract": "The herbicidal activity of Curvularia lunata toxin was assayed and indicated by inhibition to seed germination and seeding growth of weeds.The results show that seed germination of Digitaria sanguinalis weeds were restrained by the toxin to 100%.But seed germination of Echinochloa crusgali and Setaria viridis weeds were restrained lightly.When the toxin was sprayed on seedling after growing for 3 d,the D.sanguinalis seedling growth was inhibited,but the toxin had no effect on seedling for growing for 7 d.The toxin did not affect the growth of E.crusgali and S.biridis seedling.The inhibition rate of Oryza sativa and Triticum aestivum were very low and the toxin was safe.",
        "keywords": [
            "toxin",
            "Curvularia lunata",
            "herbicidal activity"
        ],
        "authors": [
            {
                "name": "TANG Shu-ge",
                "org": "College of Sciences,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "ZHENG Qi-ge",
                "org": "College of Sciences,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "MU Lin",
                "org": "College of Sciences,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "YANG Dong-wei",
                "org": "College of Sciences,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Life Science and Biotechnolgy,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Jilin Agricultural University",
        "year": 2011
    },
    "POcj5RtX": {
        "id": "POcj5RtX",
        "title": "Development and Effect of Maize Complex Seed-coating TB",
        "abstract": "It was screened to 3 strain more efficacy compatible Trichoderma and 2 strain endophytic bacteria,studied the feasibility of compound preparation with iniconazole and Carbofuran,on the basis of these,respectively,on control efficacy of soil borne disease of maize was tested in greenhouse and fields.The results showed: Trichoderma and endophytic bacteria can compound preparation with iniconazole and Carbofuran;5% complex seed coating had control efficacy similarly with Heishuijing.",
        "keywords": [
            "Trichoderma",
            "Complex seed coating",
            "Maize",
            "Endophytic bacteria"
        ],
        "authors": [
            {
                "name": "ZHENG Jun-qiang",
                "org": "Key Laboratory of North Crop Immunology China's Ministry of Agriculture,Shenyang Agricultural University,Shenyang "
            },
            {
                "name": "GAO Zeng-gui",
                "org": "Key Laboratory of North Crop Immunology China's Ministry of Agriculture,Shenyang Agricultural University,Shenyang "
            },
            {
                "name": "ZHUANG Jing-hua",
                "org": "Key Laboratory of North Crop Immunology China's Ministry of Agriculture,Shenyang Agricultural University,Shenyang "
            },
            {
                "name": "CHEN Jie",
                "org": "Key Laboratory of North Crop Immunology China's Ministry of Agriculture,Shenyang Agricultural University,Shenyang ;Shanghai Jaotong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Maize Sciences",
        "year": 2005
    },
    "hPPAKvY4": {
        "id": "hPPAKvY4",
        "title": "An investigation of arthropod community composition in ornamental plants habitat in Shanghai",
        "abstract": "We investigated the arthropod community composition in the habitat of more than 60 species of ornamental plants in Shanghai from Feb.2006 to Jan.2007.Arthropods were sorted into guilds, which were phytophages,predators,parasitoids and others.Based on the classification,there were 121 species of phytophagous arthropods,22 species of predators,12 families of parasitoids and 13 families of others.In our studies,16 arthropods were first reported in Shanghai.The relative abundance of phytophages,predators,parasitoids and others were 78.10%,5.61%,2.44% and 13.85%,respectively.One of the ecological management measures was to protect predators and parasitoids arthropods during vegetative cycle of ornamental crops.",
        "keywords": [
            "ornamental plants",
            "arthropods",
            "composition",
            "relative abundance"
        ],
        "authors": [
            {
                "name": "ZHANG Lu-min",
                "org": "School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "LIU Zhi-cheng",
                "org": "School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "TANG Hong-yan",
                "org": "School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "SUN Xing-quan",
                "org": "School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "LIU Li-xing",
                "org": "School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Entomological Journal of East China",
        "year": 2007
    },
    "fdaNehNm": {
        "id": "fdaNehNm",
        "title": "Trichoderma Mutants Screening and Analyzing for Improvement of Bio-functions",
        "abstract": "16 Trichoderma REMI mutants with capability to degrade cyanide efficiently in previous experiment were selected for assaying their antagonistic activity against five pathogens. Results suggested that there were seven mutants exhibiting good inhibition to the pathogens. Significant biocontrol of cucumber Fusarium wilt were accomplished with seven tested mutants in potted plant. Mutant TkA8 treatment reached the highest control efficiency of 73.5 %. Meanwhile, the higher activity of defense enzymes including PAL (phenylalanine ammonia lyase), POD (peroxidase) were also investigated in root after treated by TkA8. The maximum peaks of PAL and POD activity were enhanced by 3.21, 4.25 times over control respectively. So TkA8 was confirmed a Trichoderma mutant with multiple functions -- biocontrol of soilborne diseases and cyanide-degradation.",
        "keywords": [
            "biocontrol",
            "REMI mutants",
            "cyanide",
            "bioremediation"
        ],
        "authors": [
            {
                "name": "ZHOU Xiao-ying",
                "org": "School of Agriculture & Biology, Shanghai Jiaotong University, Shanghai ,China"
            },
            {
                "name": "LIU Li-xing",
                "org": "School of Agriculture & Biology, Shanghai Jiaotong University, Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture & Biology, Shanghai Jiaotong University, Shanghai ,China"
            }
        ],
        "venue": "Journal of Shanghai Jiaotong University(Agricultural Science)",
        "year": 2007
    },
    "gCnsxmMv": {
        "id": "gCnsxmMv",
        "title": "Biological characteristics of the transformants of Trichoderma harzianum T21 REMI",
        "abstract": "Some transformants performed better in most of the mentioned characteristics compared with wild ones, but others not. For example, conidium germination of strain Ttrm31 was higher than that of wild strain T21, while Ttrm47 and Ttrm94 were negative performance. The conidium productivity of Ttrm34 was higher than that of wild strain T21. However, Ttrm94 and Ttrm111 did not produce conidia at all. As for the tolerance to high-temperature, Ttrm31, Ttrm34, Ttrm47 and Ttrm76 were enhanced remarkably relative to wild strains, but Ttrm55, Ttrm94 and Ttrm111 not. Meanwhile, it was interesting that the growth of transformed Trichoderma strains was improved much once treated under high temperature (50 \u2103) for 1 hour. Ttrm55 and Ttrm76 grew faster under low temperature (15 \u2103), but Ttrm47, Ttrm76 and Ttrm111 grew faster under high temperature (30 \u2103). The transformed Trichoderma strains differed in cultural morphology, including color and sporulation, at different pHs and even on different PDAs. Their utilization of carbon and nitrogen nutrition was also different. Protein and asparagines were screened as better nitrogen sources, while glucose and maltose as better carbon sources. Thecolor of colony was also different. For example, Ttrm94 and Ttrm111 were yellow, but the others were green.",
        "keywords": [
            "Trichoderma transformants",
            "biological characteristics",
            "germination"
        ],
        "authors": [
            {
                "name": "Liu Xian",
                "org": " College of Bio-science and Technique, Shenyang Agricultural University, Shenyang , China"
            },
            {
                "name": "Gao Zenggui",
                "org": " College of Plant Protection, Shenyang Agricultural University, Shenyang , China"
            },
            {
                "name": "Zhuang Jinghua",
                "org": " College of Plant Protection, Shenyang Agricultural University, Shenyang , China"
            },
            {
                "name": "Chen Jie",
                "org": " College of Plant Protection, Shenyang Agricultural University, Shenyang , China; College of Agriculture and Biology, Shanghai Jiaotong University, Shanghai , China"
            }
        ],
        "venue": "Plant Protection",
        "year": 2006
    },
    "Kl5xXZvO": {
        "id": "Kl5xXZvO",
        "title": "Two new Chinese record species of the genus Trichoderma",
        "abstract": "[Objective] The objective of this study was to examine taxonomic position of two Trichoderma strains which were isolated from soil in southern China.[Methods] PDAm was used as a selective medium for isolating Trichoderma,then two strain was indetified by analysis of internal transcribed spacer regions of the rRNA gene cluster(ITS),partial sequences of transcription extensions factor 1-alpha(tef1-\u03b1) and observation of morphological characters.For phylogenetic analyses in MEGA 4.0,both ITS and tef1-\u03b1 gene sequences were analyzed using the maximum parsimony approach of close-neighbor-interchange algorithm with search level 3,in which the initial trees were obtained with the random addition of sequences(1 000 replicates).[Results] The ITS gene sequences of the strain CM01 were naturally clustered with ITS gene sequences of Trichoderma intricatum strain GJS 02-78 in GenBank with 99% of homology,and had the closest phylogenetic relationship with T.intricatum GJS 02-78,Trichoderma atroviride DAOM 179514 in phylogenetic tree which based on ITS sequences of strains;the tef1-\u03b1 gene sequence of the strain CM01 were naturally clustered with Hypocrea intricate strain GJS 02-78 are the closest phylogenetic relatives with 99% of homology,and had the closest phylogenetic relationship with H.intricata GJS 02-78 in phylogenetic tree which based on tef1-\u03b1 sequences of strains;its morphological description accorded with type strain\u2019s.Meantime,the ITS gene sequences of the strain SCGA5003 were naturally clustered with ITS gene sequences of Trichoderma stromaticum strain GJS 97-181 in GenBank with 99% of homology,and had the closest phylogenetic relationship with T.stromaticum GJS 97-179,GJS 97-180,GJS 97-181,GJS 97-182,GJS 97-183 in phylogenetic tree which based on ITS sequences of strains;the tef1-\u03b1 gene sequence of the strain SCGA5003 were naturally clustered with T.stromaticum strain GJS 97-183 in GenBank with 94% of homology,and had closest relationship with T.stromaticum CQSQ1032,GXNN7006 in phylogenetic tree which based on tef1-\u03b1 sequences of strains;its morphological description were consistent with type strain\u2019s.[Conclusion] Utilizing a comprehensive approaches of morphological characters and molecular identification,we concluded that we found two new Chinese record species of the genus Trichoderma,strain CM01 was identified as Trichoderma intricatum Samuels & Dodd/Hypocrea intricata Samuels et Dodd,strain SCGA5003 was identified as Trichoderma stromaticum Samuels & Pado-Schulth/Hypocrea stromatica Bezerra,Costa & Bastos.",
        "keywords": [
            "Tef1-\u03b1",
            "ITS",
            "Conidia",
            "Trichoderma intricatum",
            "Trichoderma stromaticum"
        ],
        "authors": [
            {
                "name": "SUN Rui-Yan",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai ,China"
            },
            {
                "name": "LIU Zhi-Cheng",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai ,China"
            }
        ],
        "venue": "Microbiology China",
        "year": 2013
    },
    "xMYQVslR": {
        "id": "xMYQVslR",
        "title": "Effect of soil treatment on colonization and biocontrol efficiency of Trichoderma",
        "abstract": "Trichoderma that was applied to the continuous cropping soil had been improved and disinfected was studied.The results showed that Trichoderma could survive and reproduce on the rhizophere and on the root surface.At the same time Trichoderma had no harmful effects on other beneficial microorganisms. After disinfected by high temperature,the soil microorganisms were in a state of vacuum.The vacuum state was helpful to rapid reproduction of Trichoderma,and could improve the growth of the melons and reduce the disease index of muskmelon fusarium wilt.The disease incidence of muskmelon fusarium wilt showed positive relationship with the number of Fusarium spores that survived in the soil,and showed negative relationship with the amount of Trichoderma and bacteria in the soil.",
        "keywords": [
            "Trichoderma",
            "pest biocontrol",
            "muskmelon fusarium wilt"
        ],
        "authors": [
            {
                "name": "ZHUANG Jing-hua",
                "org": ""
            },
            {
                "name": "YANG Chang-cheng",
                "org": ""
            },
            {
                "name": "MU Lian-xiao",
                "org": ""
            },
            {
                "name": "GAO Zeng-gui",
                "org": ""
            },
            {
                "name": "CHEN Jie",
                "org": ""
            }
        ],
        "venue": "Plant Protection",
        "year": 2005
    },
    "74g8KyW4": {
        "id": "74g8KyW4",
        "title": "Agrobacterium Tumefaciens-mediated Transformation of Trichoderma atroviride for Improvement of Laccase Activity",
        "abstract": "Trichoderma atroviride T23 was transferred with linear pBHT1 by agrobacterium tumefaciensmediated transformation,and 6 mutants were obtained and further identified by conventional PCR technique.Guaiacol method has been used to screen mutant strains and found that 3 mutant strains produced laccase was significantly higher than original strain T23.In the limit carbon medium,the laccase activity of the mutant strain TA5 is 25.3 U/ml.It was significantly higher than the original strains.Study found that the mutant strain TA5 produced laccase is more appropriate for acidic conditions in the context of the measured pH.When the pH is 3.5 and the temperature is 18\u2103,the laccase activity is highest.",
        "keywords": [
            "Trichoderma atroviride Agrobacterium tumefaciens-mediated transformation(ATMT) Laccase"
        ],
        "authors": [
            {
                "name": "DUAN Xing-peng",
                "org": " College of Biological Science and Technology,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "TANG Jun",
                "org": " College of Biology and Agriculture/Key Laboratory of Urban Agriculture%%#South%%#,Ministry of Agriculture,Shanghai Jiao Tong University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": " College of Biology and Agriculture/Key Laboratory of Urban Agriculture%%#South%%#,Ministry of Agriculture,Shanghai Jiao Tong University,Shanghai ,China"
            },
            {
                "name": "CHEN Hong-man",
                "org": " College of Biological Science and Technology,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "REN Da-ming",
                "org": " College of Biological Science and Technology,Shenyang Agricultural University,Shenyang ,China"
            }
        ],
        "venue": "China Biotechnology",
        "year": 2010
    },
    "50i1QqHj": {
        "id": "50i1QqHj",
        "title": "Proteomic Analysis of R17 Cucumber Differentially Expressed Proteins Induced by Powdery Mildew Fungus",
        "abstract": "Two-dimensional gel electrophoresis were employed to analyze the proteome from leaves of cucumber R17 at 24,48 and 72 h,after inoculating Sphaerotheca fuliginea. The results showed that there were significant differences between inoculated plants and control in the 2-DE map. Seven different proteins of R17 seedling leaves with qualitative changes or relatively high abundance were identified by MALDI-TOF/TOF searching NCBI,including a protein of putative phosphatidylinositol-4-phosphate 5-kinase,hypothetical protein g5bf,LHC\u2161 type I chlorophyll a/b-binding protein,ferredoxin-NADP(H) oxidoreductase,putative XS domain containing protein,unconventional myosin XI and malate dehydrogenase. This study gives new insights into pathogen stress response in cucumber leaves and demonstrates the power of the proteomic approach in plant biology studies.",
        "keywords": [
            "cucumber",
            "mass spectrometry",
            "two-dimensional gel electrophoresis",
            "powdery mildew",
            "enzymes",
            "stress",
            "proteomics",
            "proteomes",
            "malate dehydrogenase",
            "leaves",
            "stress response",
            "myosins"
        ],
        "authors": [
            {
                "name": "FAN Hai-yan",
                "org": "College of Biological Science and Technology,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai ,China"
            },
            {
                "name": "SHAO Mei-ni",
                "org": "College of Biological Science and Technology,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "XU Yu-feng",
                "org": "College of Biological Science and Technology,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "ZHANG Chun-yu",
                "org": "College of Biological Science and Technology,Shenyang Agricultural University,Shenyang ,China"
            }
        ],
        "venue": "Acta Horticulturae Sinica",
        "year": 2009
    },
    "heFpau0F": {
        "id": "heFpau0F",
        "title": "Composition and diversity of arthropod community in Chinese rose-growing field",
        "abstract": "The composition and diversity of arthropod community in Chinese rose-growing field were investigated in Shanghai between September 2006 and July 2007.The results showed that the phytophages accounted for most part of all arthropods collected,and the relative richness was 63.38% in 2006 and 48.96% in 2007.The relative richnesses of the other guilds were relatively low.Among the phytophages,Frankliniella intonsa and Myzus persicae were dominant species.Orius strigicollis and Misumenops tricuspidatus were the most predominant predator species.Both species richness and diversity index varied with seasons.",
        "keywords": [
            "guilds",
            "arthropod community",
            "chinese rose",
            "species richness",
            "diversity",
            "species diversity",
            "predators"
        ],
        "authors": [
            {
                "name": "ZHANG Lu-min",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China;Shanghai Corporation of Agricultural Means of Production,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "LIU Li-xing",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "LIU Zhi-cheng",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Acta Agriculturae Shanghai",
        "year": 2009
    },
    "o6fNGacU": {
        "id": "o6fNGacU",
        "title": "Cloning and characteristics of Brn1 gene in Curvularia lunata causing leaf spot in maize",
        "abstract": "The full length cDNA of the Brn1 was first cloned, and then expression of the Brn1 was analyzed and the function was identified by silencing technology. Results show that the full length cDNA of the C. lunata Brn1 gene contains 1001 base pairs and an 801 bp open reading frame encoding 267 amino acids. Semi-quantitative PCR analysis shows that the expression of Brn1 at 96 h is significantly higher than at 24 and 72 h (p < 0. 05) in both the highly virulent isolate CX-3 and the weakly virulent isolate DD60. Brn1-silenced transformants were light brown in culture filtrate, and have significantly reduced toxin production relative to the wild-type. These results imply that Brn1 gene in C. lunata is not only involved in 1,8-dihydroxynaphthalene melanin synthesis, but is also relatively associated with toxin biosynthesis of the pathogen. \u00a9 2011 KNPV.",
        "keywords": [
            "1",
            "8-dihydroxynaphthalene",
            "curvularia lunata",
            "gene silencing",
            "melanin",
            "toxin"
        ],
        "authors": [
            {
                "name": "Tong Liu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Shufa F. Xu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Lixing Liu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Feihong Zhou",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Jumei Hou",
                "org": "Heilongjiang Bayi Agricultural University(Heilongjiang Bayi Agricultural University),Mishan,China"
            },
            {
                "name": "Jie Chen",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            }
        ],
        "venue": "European Journal of Plant Pathology",
        "year": 2011
    },
    "9EQ5Ty6v": {
        "id": "9EQ5Ty6v",
        "title": "Genetic Polymorphism and Physiological Differentiation of Curvularia lunata on Maize",
        "abstract": "From 60 random primers,12 pairs of primers were selected to amplify the genome of Curvularia lunata,The results indicated that 128 genetic markers got amplified.On the basis of these markers,the relationships between different isolates of Curvularia lunata were clustered.The results showed that the highest similarity coefficient between these isolates was 87%,and the lowest one was 47%.When the linked distance was 0.4,22 isolates were clustered into one group.The isolates can be divided into 5-6 groups,among the groups,group a contained 6 isolates:98-36,98-25,98-17,98-07,98-01 and 98-28,their genetic distance was the closest one.",
        "keywords": [
            "Polymorphism",
            "DNA",
            "Curvulara lunata",
            "Physiological differentiation",
            "Maize"
        ],
        "authors": [
            {
                "name": "YAN Hong-hai",
                "org": "College of Plant Protection,Qingdao Agricultural University,Qingdao "
            },
            {
                "name": "CHEN Jie",
                "org": "College of Agriculture and Biotechnology,Shanghai JiaoTong University,Shanghai ,China"
            },
            {
                "name": "SONG Xi-yun",
                "org": "College of Plant Protection,Qingdao Agricultural University,Qingdao "
            }
        ],
        "venue": "Journal of Maize Sciences",
        "year": 2009
    },
    "7PoFTgPK": {
        "id": "7PoFTgPK",
        "title": "Insertional Mutagenesis of Trichoderma through Restriction Enzyme Mediated Integration (REMI) for Improvement of Cellulase Activity",
        "abstract": "Trichoderma koningii strain CICC40144 was transferred with linear pV2 DNA by restriction enzyme mediated integration,and 23 mutants were obtained and further identified by conventional PCR technique.Among 178 mutants from T.atroviride strain T23,64 mutants from T.koningii strain T30 and 23 mutants from T.koningii strain CICC40144,over 10 mutants were screened for improved cellulase activity as compared with their parent strains.Moreover one mutant among all screened mutants,TK-2R-14,was found with the highest CX(37.6 U\u00b7mL-1) and FPA(16.9 U\u00b7mL-1) activities,which were increased by 8.05% and 19.07%,respectively.",
        "keywords": [
            "Trichoderma",
            "REMI transformation",
            "cellulase"
        ],
        "authors": [
            {
                "name": "HU Shi-feng",
                "org": "School of Bio-Safety Science and Techology,Hunan Agricultural University,Changsha ;School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai "
            },
            {
                "name": "TANG Jun",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai "
            },
            {
                "name": "GAO Yong-dong",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai "
            },
            {
                "name": "LIU Li-xing",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai "
            },
            {
                "name": "GAO Bi-da",
                "org": "School of Bio-Safety Science and Techology,Hunan Agricultural University,Changsha "
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ;Key Laboratory of Microbial Metabolism,Ministry of Education,Shanghai ,China"
            }
        ],
        "venue": "Journal of Shanghai Jiaotong University(Agricultural Science)",
        "year": 2007
    },
    "D5aAee0P": {
        "id": "D5aAee0P",
        "title": "Antagonism of Mixed Fermentation Trichoderma Against Four Pathogenic Fungi",
        "abstract": "Two Trichoderma strains(SH2303 and HF3407) with good antagonistic activities against Fusarium oxysporum,Botrytis cinerea,Fusarium moniliforme and Fusarium graminearum were screened through the confrontation training from 4 Trichoderma strains T.harzianum(SH2303 and HF3407),T.aureoviride(LY1208 and SG3407).Growth characteristics and genetic stability studies were alos carried out.Results showed that SH2303 and HF3407 could grow rapidly and with better spore production capacity and genetic stability.The mixed fermentation with SH2303 and other strains was carried out.Orthogonal design of 4 factors 3 levels mixed fermentation were done thorugh optimizing selected inoculation quantity,scale,rotating speed.Experimental results showed that the SH2303 and HF3407 mixed fermentation was the best combination.The number of conidial spores could reach 4.7\u00d7107.mL-1.Compared with single fermented liquid,mixed fermented liquid treatment for cucumber had the obvious role in promoting growth and increased controlling effect on cucumber powdery mildew and fusarium wilt.Therefore,SH2303 and HF3407 could be selected as the mixed culture fermentation Trichoderma strains.",
        "keywords": [
            "screen",
            "antagonism effect",
            "Trichoderma",
            "mixed fermentation",
            "control effect determination"
        ],
        "authors": [
            {
                "name": "SONG Lei",
                "org": "College of Biological Science and Technology,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "LI Ya-qian",
                "org": "College of Biology and Agriculture/ Agricultural Environmental Microbial Engineering Research Institute,Shanghai Jiao Tong University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Biology and Agriculture/ Agricultural Environmental Microbial Engineering Research Institute,Shanghai Jiao Tong University,Shanghai ,China"
            },
            {
                "name": "YI Si-yao",
                "org": "College of Biological Science and Technology,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "REN Da-ming",
                "org": "College of Biological Science and Technology,Shenyang Agricultural University,Shenyang ,China"
            }
        ],
        "venue": "Journal of Shenyang Agricultural University",
        "year": 2012
    },
    "0E4EDzzR": {
        "id": "0E4EDzzR",
        "title": "Identification of a novel fungus, Leptosphaerulina chartarum SJTU59 and characterization of its xylanolytic enzymes.",
        "abstract": "Xylanolytic enzymes are widely used in processing industries, e.g., pulp and paper, food, livestock feeds, and textile. Furthermore, certain xylanotic enzymes have demonstrated the capability to improve the resistance and immunity of plants. Screening of high-yield microbial xylanolytic enzyme producers is significant for improving large-scale cost-effective xylanolytic enzyme production. This study provided new evidence of high-level xylanolytic enzyme production by a novel fungus, designated Leptosphaerulina chartarum SJTU59. Under laboratory conditions, L. chartarum SJTU59 produced xylanolytic enzymes of up to 17.566 U/mL (i.e., 878.307 U/g substrate). The enzyme solution was relatively stable over a wide range of pH (pH 3.0 to pH 9.0) and temperature (40\u00b0C to 65\u00b0C) while showing high resistance to the majority of metal ions tested. Composition analysis of the hydrolytic products of xylan showed sufficient degradation by xylanolytic enzymes from L. chartarum SJTU59, mainly the monosaccharide xylose, and a small amount of xylobiose were enzymatically produced; whereas in the presence of sufficient xylan substrates, mainly xylooligosaccharides, an emerging prebiotic used in food industry, were produced. In addition, the xylanolytic enzyme preparation from L. chartarum SJTU59 could initiate tissue necrosis and oxidative burst in tobacco leaves, which may be related to enhanced plant defense to adversity and disease. L. chartarum SJTU59 possessed a complex xylanolytic enzyme system, from which two novel endo-\u03b2-1,4-xylanases of the glycoside hydrolase (GH) family 10, one novel endo-\u03b2-1,4-xylanase of the GH family 11, and one novel \u03b2-xylosidase of the GH family 43 were obtained via rapid amplification of complementary DNA ends. Given the high yield and stable properties of xylanolytic enzymes produced by L. chartarum SJTU59, future studies will be conducted to characterize the properties of individual xylanolytic enzymes from L. chartarum SJTU59. xylanolytic enzymes-encoding gene(s) of potential use for industrial and agricultural applications will be screened to construct genetically engineered strains.",
        "keywords": [
            "amino acid sequence",
            "plant leaves",
            "isoenzymes",
            "biocatalysis",
            "hydrolysis",
            "temperature",
            "phylogeny",
            "metals"
        ],
        "authors": [
            {
                "name": "Qiong Wu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Yaqian Li",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Yingying Li",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Shigang Gao",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Meng Wang",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Tailong Zhang",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Jie Chen",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            }
        ],
        "venue": "PloS one",
        "year": 2013
    },
    "s00v81B4": {
        "id": "s00v81B4",
        "title": "Proteomics Related to Resistance to the Cucumber Powdery Mildew Disease in F_2 Generation of Cucumber",
        "abstract": "Proteomic approaches using two-dimensional gel electrophoresis (2-DE) were adopted to identify proteins from cucumber leaves differentially expressed in F_2 generation of cucumber. Nearly 500 proteins were reproducibly detected, including 39 specific proteins expressed in F_2 sensitive pool samples and 22 specific proteins expressed in resistance pool samples, 35 proteins were two-fold upper limit and 46 proteins were two-fold lower limit. Furthermore, analysis with MALDI-TOF-MASS showed that one important protein of disease resistance gene (SSP3110) identified in F_2 generation of cucumber associated with defensive reaction. Three proteins (SSP5412, SSP5513, SSP5710) related to respiration or photosynthesis were identified in F_2 resistant pool samples, and 14-3-3 brain protein homolog (SSP1411) was identified in F_2 sensitive pool samples. All those proteins were probably parts of network of resistance or development-related proteins. This study gives new insights into cucumber powdery mildew resistant response in cucumber leaves and demonstrates the power of the proteomic approach in plant biology studies. MS analysis of other protein spots is underway.",
        "keywords": [
            "cucumber",
            "mass spectrometry",
            "proteomics",
            "powdery mildew"
        ],
        "authors": [
            {
                "name": "FAN Hai-yan",
                "org": " School of Agriculture and Biology, Shanghai Jiaotong Univ.,Shanghai ; Biotechnical College, Shenyang Agricultural Univ.,Shenyang ,China"
            },
            {
                "name": "XU Shu-fa",
                "org": " School of Agriculture and Biology, Shanghai Jiaotong Univ.,Shanghai "
            },
            {
                "name": "CHEN Jie",
                "org": " School of Agriculture and Biology, Shanghai Jiaotong Univ.,Shanghai "
            },
            {
                "name": "CHENG Gen-wu",
                "org": " Biotechnical College, Shenyang Agricultural Univ.,Shenyang ,China"
            },
            {
                "name": "HUANG Xiu-li",
                "org": " School of Agriculture and Biology, Shanghai Jiaotong Univ.,Shanghai "
            },
            {
                "name": "WANG Xiao-fei",
                "org": " Biotechnical College, Shenyang Agricultural Univ.,Shenyang ,China"
            }
        ],
        "venue": "\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u5b66\u62a5(\u82f1\u6587\u7248)",
        "year": 2005
    },
    "iPXyqdiC": {
        "id": "iPXyqdiC",
        "title": "Influence of Combination of Two Bio-pesticides on Fungistasis of Trichoderma",
        "abstract": "The inhibitory effects of chitosan,phenazine-1-carboxylic and the mixtures of them with different ratios on Rhizoctonia solani were studied by the growth rate method.Meanwhile,the influences of combinations of chitosan and phenazine -1 -carboxylic with different ratios on fungistasis of Trichoderma on Rhizoctonia solani,and the effects of chitosan or phenazine -1 -carboxylic mixed with Trichoderma on growth and disease control of seedlings were also researched.The results showed that the chitosan,phenazine-1-carboxylic or their mixtures all had stronger inhibitory effect on the growth of Rhizoctonia solani;the combinations of chitosan and phenazine-1-carboxylic with different ratios all could enhance the fungistasis of Trichoderma on Rhizoctonia solani;the chitosan or phenazine-1-carboxylic mixed with Trichoderma all could promote the growth of maize seedlings and reduce the soil-borne diseases in seedling stage.",
        "keywords": [
            "Trichoderma",
            "bio-pesticides",
            "insecticide mixture"
        ],
        "authors": [
            {
                "name": "YAN Tang-fan",
                "org": "College of Bio-safety Science and Technology,HNAU,Changsha ,PRC;School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,PRC;The key laboratory of Urban Agriculture%%#South%%#,Ministry of Agriculture,Shanghai ,PRC"
            },
            {
                "name": "GAO Bi-da",
                "org": "College of Bio-safety Science and Technology,HNAU,Changsha ,PRC"
            },
            {
                "name": "LIU Zhi-cheng",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,PRC;The key laboratory of Urban Agriculture%%#South%%#,Ministry of Agriculture,Shanghai ,PRC"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,PRC;The key laboratory of Urban Agriculture%%#South%%#,Ministry of Agriculture,Shanghai ,PRC"
            }
        ],
        "venue": "Hunan Agricultural Sciences",
        "year": 2010
    },
    "t9qr2HLN": {
        "id": "t9qr2HLN",
        "title": "Signal Transduction of Defensive Reaction in Plant Induced by Glucohexaose",
        "abstract": "Using tobacco suspension culture and cucumber as materials,the signal transduction pathway of defensive reaction in plant induced with glucohexaose by means of conventional test method was studied to detect relative targets.The results showed that maximum of pH was 5.75 by 50 min,and content maximum of NO was 38.4\u03bcmol\u00b7mL-1 by 60min,and high active of PAL was 3.06 U\u00b7g-1\u00b7FW-1 by 80 min,and content maximum of H2O2 was 3.8\u03bcmol\u00b7g-1\u00b7FW-1by 30min,while high active of CAT was 129.3 U\u00b7g-1\u00b7W-1 on tobacco suspension cells treated with glucohexaose.By adding different inhibitors such as EGTA,neomycin,LiCl and so on,it was indicated that intracellar and extracellar Ca2+ might take part in the role in regulating release of nitric oxide and active oxygen burst on tobacco suspension cells.Systemic disease resistance of cucumber to Pseudoperonospora cubensis were induced by glucohexaose,and protective effect were 81.34%,52.12% and 6.69% respectively on leaves treated,upper leaves and lower leaves from the treated leaves.When active of PAL,H2O2,CAT,SOD were up to high on leaves treated,active of them were also up to high on upper leaves and lower leaves from the treated leaves in cucumber,here occurred signal transduction of systemic disease resistance.",
        "keywords": [
            "defensive reaction",
            "cucumber",
            "glucohexaose",
            "signal transduction",
            "tobacco suspension culture"
        ],
        "authors": [
            {
                "name": "SUN Yan-qiu",
                "org": "College of Plant Protection,Shenyang Agricultural University,Shenyang "
            },
            {
                "name": "LI Bao-ju",
                "org": "Institute of Vegetables and Flowers,CAAS,Beijing "
            },
            {
                "name": "SHI Yan-xia",
                "org": "Institute of Vegetables and Flowers,CAAS,Beijing "
            },
            {
                "name": "CAO Yuan-yin",
                "org": "College of Plant Protection,Shenyang Agricultural University,Shenyang "
            },
            {
                "name": "CHEN Jie",
                "org": "College of Agriculture and Biology,Shanghai Jiaotong University,Shanghai "
            }
        ],
        "venue": "Journal of Shenyang Agricultural University",
        "year": 2007
    },
    "k5XDtGve": {
        "id": "k5XDtGve",
        "title": "Mechanism of peracetic acid-induced resistance against verticillium eggplant wilt",
        "abstract": "Peracetic acid has proved to be an effective inducer against verticillium eggplant wilt, which could achieve a 60%\uff5e90% control effect and keep over 20 days. Peracetic acid treatment 96 h before challenge inoculation induced significant contents change of both total and soluble calcium in true leaves of eggplant resistant cultivar Xi'anluqie and susceptible cultivar Liaoqie4. For both cultivars, the calcium temporl contents changes in the leaves of different positions reflected the pathway of signal transduction related to induced resistance within plants. After challenge inoculation, total and soluble Ca~(2+) content change more greatly in the induced eggplant than in the control, derivational change of calcium contents in eggplant leaves led to the change of PAL\u3001PPO\u3001POD\u3001SOD. changed activities of which built up eggplant resistance against verticillium wilt, Ca~(2+) content change\u3001defensive enzyme activity and eggplant resistance level showed the positive correlation. therefore Ca~(2+) was presumed to participate induction of eggplant verticillium wilt defensive response through signalling, activated those defensive enzymes to improve host resistance to verticillum eggplant wilt.",
        "keywords": [
            "Chemical inducer",
            "Signal transduction",
            "Systematic acquired resistance",
            "Verticillium dahliae"
        ],
        "authors": [
            {
                "name": "TANG Bao-hong",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Bing Wang",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Jie Chen",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            }
        ],
        "venue": "Journal of Shanghai Jiaotong University (Science)",
        "year": 2005
    },
    "0K7lJ2wc": {
        "id": "0K7lJ2wc",
        "title": "Increased virulence of transgenic Trichoderma koningi strains to the Asian corn borer larvae by overexpressing heterologous chit42 gene with chitin-binding domains.",
        "abstract": "The chit42 gene cloned from Metarhizium anisopliae lacks chitin-binding domain (chBD), which plays important roles in binding insoluble chitin. Five kinds of hybrid chitinase Trichoderma transformants were constructed in this study, where the chit42 gene was fused to chBDs derived from plant, bacterial, and insect sources. The transformant Mc4 harboring chBDs from bitter melon (Momordica charantia) displayed the highest chitinase activity among all chBDs. The chitinase activities of Mc4, chit42 Trichoderma transformant Mchit3, and wild-type strain T30 were 44.94, 32.48, and 12.38 U/mL, respectively. The mortality rate of corn borer larvae in Mc4 fermentation liquid treatment increased by 10% and 30% compared with Mchit3 and T30, respectively. The midgut microvilli and goblet cell microvilli of the corn borer larvae exhibited distinct pathological changes after 48 h of feeding in Mc4 treatment. Mc4 also exhibited the strongest antifungal activity against Fusarium verticillioides and Rhizoctonia solani.",
        "keywords": [
            "asian corn borer larvae",
            "hybrid chitinase",
            "chbd",
            "trichoderma koningi",
            "chit42",
            "metarhizium anisopliae"
        ],
        "authors": [
            {
                "name": "Yingying Li",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Kehe Fu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Shigang Gao",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Qiong Wu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Lili Fan",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Yaqian Li",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Jie Chen",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            }
        ],
        "venue": "Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes",
        "year": 2013
    },
    "6tXw62uP": {
        "id": "6tXw62uP",
        "title": "Co-culture of Trichoderma atroviride SG3403 and Bacillus subtilis 22 improves the production of antifungal secondary metabolites",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Tingting Li",
                "org": "State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, China"
            },
            {
                "name": "Jiaquan Tang",
                "org": "State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, China"
            },
            {
                "name": "Valliappan Karuppiah",
                "org": "State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, China"
            },
            {
                "name": "Yaqian Li",
                "org": "State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, China"
            },
            {
                "name": "Nan Xu",
                "org": "State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, China"
            },
            {
                "name": "Jie Chen",
                "org": "State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, China"
            }
        ],
        "venue": "Biological Control",
        "year": 2019
    },
    "ZOrqCHWI": {
        "id": "ZOrqCHWI",
        "title": "Effects of Bacillus subtilis strain B20-006 on population of endophytic bacteria in corn",
        "abstract": "Treatment of corn seeds with Bacillus subtilis strain B20-006,a potential biocontrol agent,had no effect on type of endophytic bacteria on corn.However,it stimulated endophytic bacterial reproduction in the plants.B20-006 did not affect the original population of endophytic bacteria in corn roots in early stage.In late stage,population of endophytic bacteria in corn roots treated with the bacteria was significantly higher than CK.Colonization of the bacteria in corn roots would benefit the micro-ecological resistance of cultivars against the diseases.The results suggested that strain B20006 could enhance the percentage of antagonistic endophytic bacteria against Rhizoctonia solani.The percentage in the resistant cultivar,Lianyu 11 was higher than in the susceptible one,Lianyu 13.",
        "keywords": [
            "antagonism",
            "Rhizoctonia solani",
            "endophytic bacteria",
            "corn",
            "population"
        ],
        "authors": [
            {
                "name": "GAO Zeng-gui",
                "org": "~1College of Plant Protection,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "LIU Xian",
                "org": "~1College of Plant Protection,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "~1College of Plant Protection,Shenyang Agricultural University,Shenyang ,China;~2School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "ZHUANG Jing-hua",
                "org": "~1College of Plant Protection,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "XUE Chun-sheng",
                "org": "~1College of Plant Protection,Shenyang Agricultural University,Shenyang ,China"
            }
        ],
        "venue": "Acta Phytopathologica Sinica",
        "year": 2006
    },
    "yFzbPgpu": {
        "id": "yFzbPgpu",
        "title": "Microecological Relationship Between Metarizium and Trichoderma in Artificial Medium and Soil",
        "abstract": "The relationship between Trichoderma and Metarhizium cultured on the plate and in soil were studied respectively.The growth of Trichoderma and Metarhizium and the interacting effect between the two strains were observed according to the morphological colony confrontation on plate and re-isolation test from soil when the strains of Trichoderma and Metarhizium were inoculated at different proportion simultaneously.The similar observation was conducted when Metarhizium was inoculated and cultured first followed by inoculating Trichoderma at different intervals.The results showed that when Trichoderma and Metarhizium were inoculated simultaneously at the ratio of 1:100,the average growth distance of Trichoderma was as 6 times as that of Metarhizium on the plate.Metarhizium hardly isolated from Trichoderma after culturing for 4 days in soil.Therefore,Trichoderma inhibited to Metarhizium growth significantly,and it was hard for Metarhizium to grow due to the dominant growth of Trichoderma.When Metarhizium was inoculated and cultured for 7 days before inoculating Trichoderma,the growth distance of Metarhizium was 1mm lower than that of Trichoderma,and the spores quantity of Metarhizium was higher than that of Trichoderma after the two strains were in a stable growth.The growth of Trichoderma turned to be weak and the growth rate of Metarhizium increased,consequently the growth of the two strains tended to be balanced,and it could achieve a certain level of co-existence.The thorough research need to be done further more in terms of the complex microbial ecological relationships between Trichoderma and Metarhizium in soil,in order to obtain the key techniques for avoiding the direct ecologic competition of the two strains and to realize the application of the two bio-control agents together synergistically.",
        "keywords": [
            "Trichoderma",
            "synergistic effect",
            "Metarhizium"
        ],
        "authors": [
            {
                "name": "YI Si-yao",
                "org": "College of Biological Science and Technology,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Biology and Agriculture/ Agricultural Environmental Microbial Engineering Research Institute,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "SONG Lei",
                "org": "College of Biological Science and Technology,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "HUANG Lei",
                "org": "Vegetable Research Institute,Liaoning Academy of Agricultural Sciences,Shenyang ,China"
            },
            {
                "name": "LI Ya-qian",
                "org": "College of Biology and Agriculture/ Agricultural Environmental Microbial Engineering Research Institute,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Shenyang Agricultural University",
        "year": 2012
    },
    "QbsPPxj2": {
        "id": "QbsPPxj2",
        "title": "Control of transformed Trichoderma on tomato gray mold",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "LIU Xian",
                "org": "College of Bioscience Technique, Shenyang Agricultural University, Shenyang, China"
            },
            {
                "name": "GAO Zeng-gui",
                "org": "College of Plant Protection, Shenyang Agricultural University, Shenyang, China"
            },
            {
                "name": "ZHUANG Jing-hua",
                "org": "College of Plant Protection, Shenyang Agricultural University, Shenyang, China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture & Biology, Shanghai Jiaotong University, Shanghai, China"
            }
        ],
        "venue": "Acta Phytophylacica Sinica",
        "year": 2006
    },
    "HQx6ZJeK": {
        "id": "HQx6ZJeK",
        "title": "Identification Method of Pathogenicity Differentiation of Gray Leaf Spot Pathogen",
        "abstract": "The gray leaf spot(GLS) disease threatens seriously the sustainable development of maize production in recent years in North China.The identification methods of pathogenicity differentiation of GLS pathogen were studied.The seedling and,adult identifications,greenhouse and field identifications were used to examine the pathogenicity differentiation of GLS pathogen in maize inbreds and hybrids.The results showed that the resistance identification could be done at both seedling and adult plant stages.The result of the adult plant identification was better because of easier inoculation.The resistance identification using maize inbreds was superior to that of maize bybrids,because the differences of different inbred-isolate groups could be evidently examined using inbred identification of adult plants.Coefficient of variability was 47.32%.Therefore,this method can effectively examine the degree of pathogenicity differentiation of different isolates.Because of the lower coefficient of variability of hybrids identification than inbred identification in adult approach,hybrids identification in adult can be an auxiliary method of resistance identification.",
        "keywords": [
            "maize",
            "gray leaf spot pathogen",
            "identification method",
            "pathogenicity differentiation"
        ],
        "authors": [
            {
                "name": "WANG Gui-qing",
                "org": "College of Agronomy,Liaocheng University,Shandong Liaocheng ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Shenyang Agricultural University",
        "year": 2005
    },
    "pNjT2Mac": {
        "id": "pNjT2Mac",
        "title": "Studies on the interaction between Trichoderma transformants and different host plants",
        "abstract": "This paper focused on the interactions between Trichoderma transformants and different host plants.The results showed that the growth of cucumbers was not promoted by any of the transformants.Strain Trm31 imposed a negative effect on the growth of tall fescue,but the latter could not evidently influenced by other strains.Strains T21,Trm47 and Trm55 exerted a positive effect on the growth of barnyard grass,whereas strains Trm31 and Trm34 negatively affected the growth of barnyard grass.",
        "keywords": [
            "Trichoderma",
            "host plant",
            "interaction",
            "tall fescue",
            "barnyard grass"
        ],
        "authors": [
            {
                "name": "Huang Yuqian",
                "org": "Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "Liang Chunhao",
                "org": "Liaoning Academy of Agricultural Sciences,Shenyang ,China"
            },
            {
                "name": "Han Mei",
                "org": "Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "Sun Junde",
                "org": "Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "Chen Jie",
                "org": "Shenyang Agricultural University,Shenyang ,China;Shanghai Jiaotong University, Shanghai ,China"
            }
        ],
        "venue": "Plant Protection",
        "year": 2007
    },
    "ob1F1aYi": {
        "id": "ob1F1aYi",
        "title": "The dynamic changes of pathogenesis-related proteins of a low virulent Curvularia lunata isolate after reinoculating maize inbreds",
        "abstract": "Reinoculation and two-dimensional electrophoresis were performed to analyze the pathogenicity differentiation of Curvularia lunata.Resistant host inbred lines Shen135,Mo17,and 78599-1 were reinoculated(six generations) with low virulent isolate WS18.Results showed that the disease index had no significant change for the first 2 generations of inoculation.At the third generation,the incidence of disease was increased and the number of differential expressed proteins of mycelia were more than that in the first 2 generations.More than 100 differential expressed proteins were found in the mycelia of fifth generation when compared with the original one.In the experiment,10 differentially expressed proteins were identified by MALDI-TOF-MS analysis.Three proteins were related directly to the differentiation of virulence,2 were related to allergen,4 were related to the metabolism of carbon or signaling pathway and 1 was unkonwn to Curvularia lunata.",
        "keywords": [
            "maize",
            "Curvularia lunata",
            "proteomics",
            "pathogenicity differentiation"
        ],
        "authors": [
            {
                "name": "ZHAI Yu-hong",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "LIU Li-xing",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "HUANG Xiu-li",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "CHENG Xiao-zhou",
                "org": "Departemt of Plant Protection,Shandong Agriculture University,Taian ,China"
            },
            {
                "name": "ZHU Heng",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "CHEN Yun-peng",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "XU Shu-fa",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Acta Phytopathologica Sinica",
        "year": 2008
    },
    "zz0a5E8D": {
        "id": "zz0a5E8D",
        "title": "Analysis of Isozymes and Proteins Related to Physiological Differentiation of Curvularia lunata in Maize",
        "abstract": "Soluble proteins and isozymes of SOD,ETS,PPO,MDH,PO extracted from 23 strains of Curvularia lunata were analyzed by electrophoresis technology,the results indicated that there were differences among different strains.Cluster analysis with physiological differentiation among different strains showed that,when the interconnection distance was 0.36,23 strains were clustered to 7 groups,which were similar to the groups clustered with pathogenic differentiation.However,there were some differences between groups clustered by physiological differentiation and pathogenic differentiation.",
        "keywords": [
            "isozyme",
            "physiological differentiation",
            "curvularia lunata"
        ],
        "authors": [
            {
                "name": "Yan Honghai",
                "org": "College of Agronomy and Plant Protection,Qingdao Agricultural University,Qingdao Shandong "
            },
            {
                "name": "Chen Jie",
                "org": "College of Agriculture and Biology,Shanghai Jiaotong University,Shanghai "
            },
            {
                "name": "Song Xiyun",
                "org": "College of Agronomy and Plant Protection,Qingdao Agricultural University,Qingdao Shandong "
            }
        ],
        "venue": "Chinese Agricultural Science Bulletin",
        "year": 2009
    },
    "nd3hfJdh": {
        "id": "nd3hfJdh",
        "title": "Trichoderma koningiopsis:A New Chinese Record of the Genus Trichoderma",
        "abstract": "We found a new Chinese record of the genus Trichoderma using the method of ITS and morporlogy from the east China.The species is Trichoderma koningiopsis/Hypocrea koningiopsis Samuels,C.Suarez & H.C.Evans sp.nov..Percurrently proliferating phialides is the typical morphology of this species on PDA and CMD,while it doesn't exist on MA.",
        "keywords": [
            "Biocontrol",
            "Trichoderma koningiopsis",
            "Genus Trichoderma"
        ],
        "authors": [
            {
                "name": "LI Guang-Ji",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "LIU Tong",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "LIU Li-Xing",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Microbiology China",
        "year": 2010
    },
    "xkTpWNe4": {
        "id": "xkTpWNe4",
        "title": "Study on Genetic Diversity of Sporisorium Reilianum",
        "abstract": "Nine single primers and three double primers were screened from 169 random primers for RAPD. The SPSS software was used to analyses the cluster. Based on the RAPD marks, 24 strains were grouped into three types. 03-12, 03-13, 03-01, 03-02, 03-03, 03-11, 03-04, 03-16, 03-07, 03-08 and 03-14 were divided into a group. 03-18, 03-20, 03-17, 03-26, 03-29, 03-27, 03-23, 03-25 and 03-28 were second group. 03-21, 03-22 and 03-10 were third one. The results showed that there actually existed genetic differentiation which is not related to strain resource among different Sporisorium reilianum strains.",
        "keywords": [
            "Sporisorium reilianum",
            "Cluster analysis",
            "DNA genetic diversity",
            "RAPD"
        ],
        "authors": [
            {
                "name": "HE Zi-dian",
                "org": " Hebei Normal University of Science & Technology, Qinhuangdao "
            },
            {
                "name": "CHEN Jie",
                "org": " Agriculture and Biology College, Shanghai Jiaotong University, Shanghai "
            },
            {
                "name": "GAO Zeng-gui",
                "org": " Shenyang Agricultural University, Shenyang , China"
            },
            {
                "name": "ZHUANG Jing-hua",
                "org": " Shenyang Agricultural University, Shenyang , China"
            },
            {
                "name": "GAO Yu-feng",
                "org": " Hebei Normal University of Science & Technology, Qinhuangdao "
            }
        ],
        "venue": "Journal of Maize Sciences",
        "year": 2007
    },
    "cMualhvW": {
        "id": "cMualhvW",
        "title": "Effects of Different Mutant Inoculant on Rice Straw Degradation and Vegetable Growth",
        "abstract": "Straw was mainly composed by cellulose,hemicellulose and Lignin This study was investigated on rice straw biodegradation by using cellulase-producing Trichoderma strains.And the performance of seven formulations of Trichoderma REMI mutant inoculant(SDTI) used to decompose straw was investigated in many aspects such as cellulose activities,reduced sugar and the contents of nitrogen,phosphorus and potassium.The results showed that carboxymethyl cellulase activities and reduced sugar contents reached 3.48U.g-1 and 17.14 mg.g-1,respectively.In the decomposed rice straw manure prepared by SDTI only containing H6 strains.Filter paper enzyme activity in decomposing straw manure was improved,but the difference was not significant relative to the control.Nitrogen,phosphorus and potassium content in decomposed straw manure prepared by most of SDTIs were also increased significantly relative to the control.Pot experiments showed that the decomposing straw manure could significantly promote the growth of tomato and cucumber.",
        "keywords": [
            "degradation",
            "trichoderma",
            "rice straw",
            "decomposing inoculant",
            "growth",
            "nitrogen",
            "biodegradation",
            "phosphorus",
            "cellulase",
            "enzyme activity",
            "enzymes",
            "mutants",
            "potassium"
        ],
        "authors": [
            {
                "name": "DUAN Xing-peng",
                "org": "College of Biological Science and Technology,Shenyang Agricultural University,Shenyang ,China;College of Biology and Agriculture/ Key laboratory of Urban Agriculture%%#South%%#,Ministry of Agriculture,Shanghai Jiao Tong University,Shanghai ,China"
            },
            {
                "name": "YANG Li-fan",
                "org": "College of Agronomy,Si Chuan Agricultural University,Yaan ,China;College of Biology and Agriculture/ Key laboratory of Urban Agriculture%%#South%%#,Ministry of Agriculture,Shanghai Jiao Tong University,Shanghai ,China"
            },
            {
                "name": "YANG Xiao-hua",
                "org": "Jinshan District Agro-Technology Extension Center,Shanghai"
            },
            {
                "name": "REN Da-ming",
                "org": "College of Biological Science and Technology,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "HUANG Yun",
                "org": "College of Agronomy,Si Chuan Agricultural University,Yaan ,China"
            },
            {
                "name": "LIU Zhi-cheng",
                "org": "College of Biology and Agriculture/ Key laboratory of Urban Agriculture%%#South%%#,Ministry of Agriculture,Shanghai Jiao Tong University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Biology and Agriculture/ Key laboratory of Urban Agriculture%%#South%%#,Ministry of Agriculture,Shanghai Jiao Tong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Shenyang Agricultural University",
        "year": 2009
    },
    "l7aKP7pZ": {
        "id": "l7aKP7pZ",
        "title": "Biological Functions of the Gene PLA_2 of T.koningii and its Induced Resistance Against Curvularia lunata",
        "abstract": "In this study,we cloned the gene of PLA2 from cDNA of the wide type T.koningii T30,and then investigated the biological functions of the PLA2-deletion mutant and the role of PLA2demonstrated the interaction between maize and T.koningii after challenged inoculation with Curvularia lunata.The activity of exo-chitinase and \u03b2-1,3-glucanase of the mutant was a little lower than that of the wild type.Furthermore,the mutant provided a higher control of Curvularia leaf spot on the potted maize in comparison with the wild type strain.Similarly,it had been infiltrated with prokaryotic expression protein of PLA2 got larger lesions on the detached leaves than the controls.Thus we speculated that PLA2 might be involved in the Trichoderma-induced maize defensive pathway against Curvularia leaf spot in a negative regulation.The function of PLA2 in detail to non-compatible interaction between Trichoderma spp.and maize need to be further studied through its complemental experiments.",
        "keywords": [
            "PLA2",
            "Induced resistance",
            "PLA2-deletion mutant",
            "Curvularia lunata"
        ],
        "authors": [
            {
                "name": "XU Zhi-hua",
                "org": "Key Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China;Mycotoxin Laboratory of Agricultural University of Hebei,Baoding ,Hebei Province,China"
            },
            {
                "name": "YU Chuan-jin",
                "org": "The National Maize Industry Technology RD Center,Beijing,,China;Key Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "FU Ke-he",
                "org": "The National Maize Industry Technology RD Center,Beijing,,China;Key Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "LIN Zhen-ya",
                "org": "The National Maize Industry Technology RD Center,Beijing,,China;Key Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "JING Jing",
                "org": "The National Maize Industry Technology RD Center,Beijing,,China;Key Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "WANG Bing",
                "org": "Key Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "DONG Jin-gao",
                "org": "Mycotoxin Laboratory of Agricultural University of Hebei,Baoding ,Hebei Province,China"
            },
            {
                "name": "CHEN Jie",
                "org": "The National Maize Industry Technology RD Center,Beijing,,China;Key Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Shanghai Jiaotong University(Agricultural Science)",
        "year": 2011
    },
    "3AT9zwTI": {
        "id": "3AT9zwTI",
        "title": "Streptomyces lydicus A01 affects soil microbial diversity, improving growth and resilience in tomato.",
        "abstract": "The actinomycete Streptomyces lydicus A01 promotes tomato seedling growth; however, the underlying mechanism is unclear. In this study, we investigated whether changes in soil microbial diversity, following Streptomyces lydicus A01 treatment, were responsible for the increased tomato seedling growth. Eukaryotic 18S ribosomal DNA (rDNA) sequencing showed that S. lydicus A01-treated and untreated soil shared 193 operational taxonomic units (OTUs), whereas bacterial 16S rDNA sequencing identified 1,219 shared OTUs between the treated and untreated soil. Of the 42 dominant eukaryotic OTUs, 8 were significantly increased and 6 were significantly decreased after A01 treatment. Of the 25 dominant bacterial OTUs, 12 were significantly increased and 8 were significantly decreased after A01 treatment. Most of the eukaryotes and bacteria that increased in abundance exhibited growth promoting characteristics, which were mainly predicted to be associated with mineralization of nitrogen and phosphorus, phosphate solubilization, nutrient accumulation, and secretion of auxin, whereas some were related to plant protection, such as the degradation of toxic and hazardous substances. Soil composition tests showed that S. lydicus A01 treatment enhanced the utilization of nitrogen, phosphorus, and potassium in tomato seedlings. Thus, microbial fertilizers based on S. lydicus A01 may improve plant growth, without the detriment effects of chemical fertilizers.",
        "keywords": "",
        "authors": [
            {
                "name": "Qiong Wu",
                "org": "Laboratory of Biological Microbiology, Institute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China."
            },
            {
                "name": "Caige Lu",
                "org": "Laboratory of Biological Microbiology, Institute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China."
            },
            {
                "name": "Mi Ni",
                "org": "Laboratory of Biological Microbiology, Institute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China."
            },
            {
                "name": "Hongli Wang",
                "org": "Laboratory of Biological Microbiology, Institute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China."
            },
            {
                "name": "Weicheng Liu",
                "org": "Laboratory of Biological Microbiology, Institute of Plant and Environment Protection, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China."
            },
            {
                "name": "Jie Chen",
                "org": "The Key laboratory of Urban (South) Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China."
            }
        ],
        "venue": "Journal of integrative plant biology",
        "year": 2018
    },
    "m2odJxRG": {
        "id": "m2odJxRG",
        "title": "Accumulation of copper in <i>Trichoderma reesei</i> transformants, constructed with the modified <i>Agrobacterium tumefaciens</i>-mediated transformation technique",
        "abstract": "A modified Agrobacterium tumefaciens-mediated transformation method was established for the construction of mutants with improved copper tolerance and accumulation\n capability in Trichoderma reesei. One transformant, AT01, exhibited the highest copper accumulation capability. With copper at 0.7\u00a0mM, AT01 removed 13\u00a0mg\n copper/g biomass (removal rate of 96%), whereas the wild-type strain removed only 6\u00a0mg copper/g biomass (removal rate of 50%).\n Optimal conditions were a pH of 5.0 at 28\u00b0C. The pigment change of Trichoderma mycelia was a potential indicator of copper accumulation. Electron microscopy revealed that copper was mainly accumulated\n in cell vacuoles.",
        "keywords": [
            "agrobacterium tumefaciens-mediated transformationcopper accumulationtrichoderma reesei"
        ],
        "authors": [
            {
                "name": "Kehe Fu",
                "org": "Department of Resource and Environmental Science, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, 200240 People\u2019s Republic of China"
            },
            {
                "name": "Lixing Liu",
                "org": "Department of Resource and Environmental Science, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, 200240 People\u2019s Republic of China"
            },
            {
                "name": "Lili Fan",
                "org": "Department of Resource and Environmental Science, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, 200240 People\u2019s Republic of China"
            },
            {
                "name": "Tong Liu",
                "org": "Department of Resource and Environmental Science, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, 200240 People\u2019s Republic of China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Resource and Environmental Science, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, 200240 People\u2019s Republic of China"
            }
        ],
        "venue": "Biotechnology Letters",
        "year": 2010
    },
    "ig0lx6Z7": {
        "id": "ig0lx6Z7",
        "title": "Agrobacterium tumefaciens-mediated Transformation (ATMT) of Trichoderma atroviride T23",
        "abstract": "Agrobacterium tumefaciens-mediated transformation (ATMT) was applied in Trichoderma atroviride strain T23. Meanwhile, the transformation method was optimized by adjusting the concentration of hygromycin B in selection medium and exploring the incubation time of Agrobacterial AGL-1 cells. The transformation efficiency was about 50 transformants per 107 conidia. All transformants were successively subcultured for five generations, and then screened on selective plates, 118 genetically stable transformants were obtained. Some of them were randomly selected to conduct PCR and Southern blotting analysis, and the result showed that all transformants tested were arbitrarily integrated with exogenous T-DNA in genome. Compared to wild-type strain T23, three transformants were obviously different in spore production and mycelia growth rate. The successful application of ATMT technique in T. atroviride T23 will facilitate the study of functional genome of this organism.",
        "keywords": [
            "agrobacterium tumefaciens",
            "hygromycin b resistance",
            "transformants",
            "trichoderma atroviride",
            "genetic stability",
            "genetic transformation",
            "genetic analysis",
            "genes",
            "genomes",
            "polymerase chain reaction"
        ],
        "authors": [
            {
                "name": "SUN Wen-liang",
                "org": " School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai , China; College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua , China"
            },
            {
                "name": "HU Xiao-lu",
                "org": " School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai , China"
            },
            {
                "name": "WU Meng-zhang",
                "org": " School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai , China"
            },
            {
                "name": "CHEN Jie",
                "org": " School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai , China"
            },
            {
                "name": "LIU Peng",
                "org": " College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua , China"
            },
            {
                "name": "CHEN Yun-peng",
                "org": " School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai , China"
            }
        ],
        "venue": "Journal of Shanghai Jiaotong University(Agricultural Science)",
        "year": 2009
    },
    "pfi8NUI2": {
        "id": "pfi8NUI2",
        "title": "Induction of Substances Related to Resistance in Host to Shealth Blight of Maize by Bio-seed-coating Agent",
        "abstract": "Dynamic the effective function of biological seed coating ZSB and changes of in active of peroxideases (POD),polyphenoloxides (PPO) and phenylalantine ammonia lyases (PAL) in two resistant cultivars and two susceptible ones of maize after inoculating Rhizoctonia solani were studied in the paper.The results showed that ZSB had an effective function to control sheath blight of four cultivars of maize.The effective function to Washi13 and Shenshi28 was 39% and 49.7%,which was higher than that of Yedan13 and Shenshi29.It was more likely that ZSB control effect was devoted by its induction to PPO and POD in host prior to and higher than inoculation with R.solani.It should be noted that some special phenomenon such as still no significant increase of PAL needed to be further investigated.",
        "keywords": [
            "Bio-seed-coating",
            "Induced resistance",
            "Enzymes activity",
            "Maize sheath blight"
        ],
        "authors": [
            {
                "name": "Li Ronghua",
                "org": "School of Environment and Safety Engineering,Tianjin University of Technology,Tianjin ; College of Plant Protection,Shenyang Agricultural University,Shenyang "
            },
            {
                "name": "Chen Jie",
                "org": " College of Plant Protection,Shenyang Agricultural University,Shenyang ;College of Agriculture and Biology,Shanghai Jiaotong University,Shanhai "
            },
            {
                "name": "Tang Baohong",
                "org": " College of Plant Protection,Shenyang Agricultural University,Shenyang "
            },
            {
                "name": "Liu Junhua",
                "org": " College of Plant Protection,Shenyang Agricultural University,Shenyang "
            }
        ],
        "venue": "Chinese Agricultural Science Bulletin",
        "year": 2006
    },
    "vDCmh8r7": {
        "id": "vDCmh8r7",
        "title": "Agrobacterium tumefaciens-mediated Transformation of Curvularia lunata",
        "abstract": "Agrobacterium tumefaciens-mediated transformation (ATMT) was a highly efficient transformation to filamentous fungi,it has been extensively applied to many fungi, such as Fusarium, Trichoderma,etc.Curvularia lunata CX-3, which was strong pathogenicity to maize, andit was successfully transformed by ATMT, 30 genetically stable transformants was obtained, and all of them had resistance to hygromycin B.11 of them were randomly selected to conduct PCR, and the result showed that the T-DNA had been integrated into genome of CX-3.Compared to wild strain CX-3,6 transformants were obviously different in colour, growth rate and spore production.",
        "keywords": [
            "Agrobacterium tumefaciens",
            "Curvularia lunata CX-3",
            "T-DNA"
        ],
        "authors": [
            {
                "name": "HUANG Wei-dong",
                "org": "The Key Laboratory of Northern Crop Disease Immunity of China Ministry of Agriculture, Laboratory of Molecular and Physiological Plant Pathology of Shenyang Agricultural University,Shenyang , China"
            },
            {
                "name": "XUE Chun-sheng",
                "org": "The Key Laboratory of Northern Crop Disease Immunity of China Ministry of Agriculture, Laboratory of Molecular and Physiological Plant Pathology of Shenyang Agricultural University,Shenyang , China"
            },
            {
                "name": "ZHAO Zhi-wei",
                "org": "The Key Laboratory of Northern Crop Disease Immunity of China Ministry of Agriculture, Laboratory of Molecular and Physiological Plant Pathology of Shenyang Agricultural University,Shenyang , China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai , China"
            }
        ],
        "venue": "Hubei Agricultural Sciences",
        "year": 2010
    },
    "xQvVgzpa": {
        "id": "xQvVgzpa",
        "title": "Construction and characterization of yeast two hybrid cDNA library of Curvularia lunata",
        "abstract": "BD SMART technique and LD-PCR were applied to synthesize double strand cDNA(ds cDNA).The ds cDNA and pGADT7-Rec were transfered into competent yeast cell to construct yeast two-hybrid cDNA library of Curvularia lunata by homologous recombination method.The results showed that library capacitance was 2.46\u00d7105 and transformation rate was 2.13\u00d7105/\u03bcg pGADT7-Rec.The plaque titer of the library was 2.5\u00d7108 pfu/mL and the recombination frequency was 88.24%.The length of inserted cDNA fragment was ranged from 0.4 kb to 3 kb in average.This is the first time to use BD SMART technique to construct yeast two-hybrid cDNA library of C.lunata by homologous recombination.",
        "keywords": [
            "cDNA library",
            "yeast two-hybrid",
            "Curvularia lunata"
        ],
        "authors": [
            {
                "name": "JING Jing",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Key Laboratory of Urban Agriculture%%#South%%#,Ministry of Agriculture,Shanghai ,China"
            },
            {
                "name": "LIU Tong",
                "org": "School of Agriculture,Heilongjiang Bayi Agricultural University,Daqing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Key Laboratory of Urban Agriculture%%#South%%#,Ministry of Agriculture,Shanghai ,China"
            }
        ],
        "venue": "Acta Phytopathologica Sinica",
        "year": 2012
    },
    "mEm26diV": {
        "id": "mEm26diV",
        "title": "A Study on the Polymorphism of Protein in Head Smut Pathogen in Maize",
        "abstract": "The polymorphism of different strains of head smut pathogens in maize collected from the main maize growing areas was studied in this paper.Based on their protein and isozyme profiles through PAGE,the differentiation and similarity among strains was clustered by SPSS software.The result showed that head smut pathogens in maize had obvious physiological differentiation at protein and isozyme level.23 strains were classified into 6 groups based on profiles.However,there is not enough evidence to show the regulation of isozyme spectrum bands among pathogen strains from the different collection locations.It is possible this phenomenon shows that there is not an obvious correlation between the physiological differential of pathogens and their location in the isozyme and protein level.",
        "keywords": [
            "maize head smut pathogen(Sporisorium reilianum)",
            "protein and isozyme polymorphism",
            "cluster analysis"
        ],
        "authors": [
            {
                "name": "HE Zi-dian",
                "org": " Dept of Agronomy,HNUST,Qinhuangdao Hebei,"
            },
            {
                "name": "CHEN Jie",
                "org": " College of Agriculture and Biology,Shanghai Jiaotong University"
            },
            {
                "name": "GAO Zeng-gui",
                "org": " Key Laboratory of Northern Crop Immunology China's Ministry of Agriculture,Shenyang Agricultural University"
            },
            {
                "name": "ZHUANG Jing-hua",
                "org": " Key Laboratory of Northern Crop Immunology China's Ministry of Agriculture,Shenyang Agricultural University"
            },
            {
                "name": "GAO Yu-feng",
                "org": " Dept of Agronomy,HNUST,Qinhuangdao Hebei,"
            }
        ],
        "venue": "Journal of Hebei Normal University of Science & Technology",
        "year": 2007
    },
    "HK3Nov91": {
        "id": "HK3Nov91",
        "title": "A MAP kinase gene, Clk1, is required for conidiation and pathogenicity in the phytopathogenic fungus Curvularia lunata",
        "abstract": "Mitogen-activated protein kinase (MAPK) cascades are highly conserved signal transduction pathways, which play a wide variety of important roles in extracellular signal transduction. The first MAPK gene of the maize pathogen Curvularia lunata, Clk1, was isolated via a PCR-based approach with a primer pair designed on the basis of conserved regions of known MAPKs. Southern blot analysis showed that the gene existed in the genome as a single copy. The predicted amino acid sequence (352 amino acids) was highly homologous with MAP kinases of other phytopathogenic fungi. Flanking regions of Clk1 were obtained through RACE and genomic walking technology. To understand the role of Clk1 in C. lunata, targeted gene disruption was adopted to construct Clk1 mutants. It was found that mutants lacking functional domain of Clk1 were not able to produce conidia but tended to form a few special chlamydospore-shaped structures. Clk1 mutants grew slower in adverse environments (at 24\u00b0C), produced less cell degrading enzymes (CWDEs) than the wild type, and they were almost unable to infect maize leaves via artificial wounds. \u00a9 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",
        "keywords": [
            "conidiation",
            "curvularia lunata",
            "mitogen-activated protein kinase",
            "pathogenicity",
            "mitogen activated protein kinase"
        ],
        "authors": [
            {
                "name": "Shi Gang Gao",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Fei Hong Zhou",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Tong Liu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Ying Ying Li",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Jie Chen",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            }
        ],
        "venue": "Journal of Basic Microbiology",
        "year": 2013
    },
    "sjnjLYcx": {
        "id": "sjnjLYcx",
        "title": "Sm1 gene cloning from Trichoderma virens,prokaryotic expression and protein purification",
        "abstract": "Trichoderma spp.have been recognized as the agents for the biocontrol of plant disease.They produce or release a variety of compounds that induce localized or systemic resistance responses in plants.In this study,Sm1 gene was cloned from Trichoderma virens(YZ2612).Sequence analysis showed that the cDNA fragment had an ORF with length of 414 bp encoding 138 amino acid residues.The recombinant prokar-yotic expression vector pET-28a(+)-Sm1 was constructed,and then transformed into Escherichia coli BL21(DE3).IPTG concentration,induction time and temperature were optimized for enhancing fused protein expression,It was revealed that the best expression was achieved under conditions of 24\u2103 and 1 mmol/L of IPTG for 4 hours.The recombinant protein was solubilized,denatured,refolded,and purified.These results might offer an important gene resource for being used to construct transgenic resistant lines of plants and to prepare new kind of protein biofungicide.",
        "keywords": [
            "Trichoderma",
            "Sm1 gene",
            "prokaryotic expression",
            "protein purification"
        ],
        "authors": [
            {
                "name": "ZHU Jie-wei",
                "org": "School of Agriculture and Biology and Key Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,Shanghai Jiao Tong University,Shanghai ,China"
            },
            {
                "name": "WU Qiong",
                "org": "School of Agriculture and Biology and Key Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,Shanghai Jiao Tong University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology and Key Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,Shanghai Jiao Tong University,Shanghai ,China"
            }
        ],
        "venue": "Acta Phytopathologica Sinica",
        "year": 2012
    },
    "NqC3LrLx": {
        "id": "NqC3LrLx",
        "title": "Population Dynamics of Orius strigicollis and Frankliniella intonsa on Chinese Rose and Predatory Functional Response",
        "abstract": "Population dynamics of Frankliniella intonsa and Orius strigicollis on Chinese rose were investigated in 2006 and 2007 at the Experimental Farm of Shanghai Jiao Tong University,Shanghai,China. In Chinese rose filed,F.intonsa was the most dominant pest species and O.strigicollis was the most abundant predator,and both showed one population peak in each year.Population dynamics of F.intonsa correlated well with the abundance of O.strigicollis.The functional response of O.strigicollis to F.intonsa was studied in laboratory experiments.O.strigicollis demonstrated a Holling type\u2161functional response to F.intonsa.Predation rate varied with the densities of F.intonsa.Theoretical daily maximum predatory capacity of 0.strigicollis on F.intonsa was 15.79.Estimated attack coefficient and handling time by the disc equation were 0.025 h~(-1) and 1.52 h,respectively.The current results show that O.strigicollis can be a promising biocontrol agent against thrips on Chinese rose.",
        "keywords": [
            "functional response",
            "Orius strigicollis",
            "Frankliniella intonsa",
            "Chinese rose",
            "population dynamics"
        ],
        "authors": [
            {
                "name": "ZHANG Lu-min",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai ,China"
            },
            {
                "name": "LIU Zhi-cheng",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai ,China"
            },
            {
                "name": "SUN Xing-quan",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai ,China"
            },
            {
                "name": "LIU Li-xing",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai ,China"
            }
        ],
        "venue": "Chinese Journal of Biological Control",
        "year": 2008
    },
    "UetJnX5P": {
        "id": "UetJnX5P",
        "title": "Construction of a Streptomyces lydicus A01 transformant with a chit42 gene from Trichoderma harzianum P1 and evaluation of its biocontrol activity against Botrytis cinerea.",
        "abstract": "Streptomyces lydicus A01 and Trichoderma harzianum P1 are potential biocontrol agents of fungal diseases in plants. S. lydicus A01 produces natamycin to bind the ergosterol of the fungal cell membrane and inhibits the growth of Botrytis cinerea. T. harzianum P1, on the other hand, features high chitinase activity and decomposes the chitin in the cell wall of B. cinerea. To obtain the synergistic biocontrol effects of chitinase and natamycin on Botrytis cinerea, this study transformed the chit42 gene from T. harzianum P1 to S. lydicus A01. The conjugal transformant (CT) of S. lydicus A01 with the chit42 gene was detected using polymerase chain reaction (PCR). Associated chitinase activity and natamycin production were examined using the 3, 5-dinitrosalicylic acid (DNS) method and ultraviolet spectrophotometry, respectively. The S. lydicus A01-chit42 CT showed substantially higher chitinase activity and natamycin production than its wild type strain (WT). Consequently, the biocontrol effects of S. lydicus A01-chit42 CT on B. cinerea, including inhibition to spore germination and mycelial growth, were highly improved compared with those of the WT. Our research indicates that the biocontrol effect of Streptomyces can be highly improved by transforming the exogenous resistance gene, i.e. chit42 from Trichoderma, which not only enhances the production of antibiotics, but also provides a supplementary function by degrading the cell walls of the pathogens.",
        "keywords": [
            "chitinase activity",
            "streptomyces lydicus a01",
            "botrytis cinerea",
            "natamycin production",
            "chit42 from trichoderma harzianum p1"
        ],
        "authors": [
            {
                "name": "Qiong Wu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Linquan Bai",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Weicheng Liu",
                "org": "Beijing Academy of Agriculture and Forestry Sciences(Beijing Academy of Agricultural and Forestry Sciences,Beijing Academy of Agriculture and Forest),Beijing,China"
            },
            {
                "name": "Yingying Li",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Caige Lu",
                "org": "Beijing Academy of Agriculture and Forestry Sciences(Beijing Academy of Agricultural and Forestry Sciences,Beijing Academy of Agriculture and Forest),Beijing,China"
            },
            {
                "name": "Yaqian Li",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Kehe Fu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Chuanjin Yu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Jie Chen",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            }
        ],
        "venue": "Journal of microbiology (Seoul, Korea)",
        "year": 2013
    },
    "tFq0hxUF": {
        "id": "tFq0hxUF",
        "title": "Insertion mutagenesis of trichoderma atroviride by restriction enzyme-mediated DNA integration",
        "abstract": "Restriction enzyme-mediated integration (REMI) of DNA has been recently received attention as a new technique for the generation of mutants by transformation in fungi. Trichoderma atroviride strain T23 was transformed with linearized plasmid pV2, conferring resistance to hygromycin B, in the presence of restriction enzyme used to linearize the plasmid. A total of 172 regeneration transformants were detected by successive inoculation for seven times subcultivation on fresh PDA plate containing hygromycin B. The plasmid was integrated stably into the chromosome DNA, which was confirmed by PCR and southern analysis. The difference between 172 transformants and the parent strain was confirmed in colonial color, sporulation and growth rate. The results showed that the significant difference appeared in above mentioned characters between transformants and parent strain is sporulation capability. Transformants TC6, TD5, TE7, TF1 and TK1 produced higher amounts of conidia than the parent strain T23. In addition, transformants TKland TC6 showed stronger inhibition to the growth rate of the cucumber wilt pathogen (Fusarium oxyporum) in vitro.",
        "keywords": [
            "Hygromycin resistance",
            "Restriction enzyme-mediated integration",
            "Trichoderma atrovride"
        ],
        "authors": [
            {
                "name": "HUANG Yu-qian",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "ZHOU Xiao-ying",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Jie Chen",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "LIANG Chun-hao",
                "org": "Liaoning Academy of Agricultural Sciences(Liaoning Academy of Agricultural Sciences,Liaoning Academy of Agricultural Science),Shenyang,China"
            },
            {
                "name": "FAN Hai-yan",
                "org": "Shenyang Agricultural University(Shenyang Agricultural University),Shenyang,China"
            },
            {
                "name": "Shufa F. Xu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Gen W. Cheng",
                "org": "Shenyang Agricultural University(Shenyang Agricultural University),Shenyang,China"
            },
            {
                "name": "LIU Hai-nan",
                "org": "Shenyang Agricultural University(Shenyang Agricultural University),Shenyang,China"
            }
        ],
        "venue": "Journal of Shanghai Jiaotong University (Science)",
        "year": 2005
    },
    "YeIkkoW9": {
        "id": "YeIkkoW9",
        "title": "Mutation of Trichoderma in tolerance to pyrimethanil and induction of related protein",
        "abstract": "Induce of biocontrol strain tolerance of Trichoderrna to chemical fungicides was studied.Two mu- tants tolerant to pyrimethanil were obtained by UV-light induction on PDA amended with pyrimethaniol from a wild Trichoderma strain.Tolerance level was over 20 times in comparison with that of the mother strain.The mutants could maintain their tolerance after 8 times of transfers on the fungicide free PDA.The soluble protein profile bands of tolerant strains were higher than that of their original sensitive strains among which,the toler- ant strains owned the soluble protein profile band of R_f=0.64.But it was not shown in sensitive strains,and it is called related tolerant protein.This protein was purified from KTm-1 by Sephadex G-100 gel filtration. The molecular weight of tolerant protein was determined to be 44.1 KDa.Two tolerant strains kept the ability of antagonism against Botrytis cinerea in vitro and vivo.",
        "keywords": [
            "Trichoderma",
            "tolerance",
            "pyrimethaniol",
            "mutant"
        ],
        "authors": [
            {
                "name": "CHEN Hong-man",
                "org": " College of Agricultural and Biology,Shanghai Communication University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": " College of Agricultural and Biology,Shanghai Communication University,Shanghai ,China"
            },
            {
                "name": "KAN Guo-shi",
                "org": " College of Agricultural and Biology,Shanghai Communication University,Shanghai ,China"
            },
            {
                "name": "LI He-min",
                "org": " College of Agricultural and Biology,Shanghai Communication University,Shanghai ,China"
            }
        ],
        "venue": "Journal of\u3000Plant Protection",
        "year": 2005
    },
    "8rp5iXm4": {
        "id": "8rp5iXm4",
        "title": "Mechanisms of System Signal Transduction and Constriction Resistance in Cucumber Induced by Glucohexaose",
        "abstract": "In order to explore the mechanism of the systemic resistance to cucumber downy mildew induced by plant glucohexaose,the physiological and biochemical method was employed to study the changes in contents of lignin,phenolic compound,Ca2+,Salicylic acid(SA),Jasmonic Acid(JA) and activities of Phenylalanine ammonia-lyase(PAL),Peroxidase(POD) in cucumber leaves at different positions pretreated with glucohexaose.The results showed that glucohexaose could induce system resistance of cucumber treated leaves,upper leaves from the treated leaves,lower leaves from the treated leaves to Pseudoperonospora cubensis,and the contents of lignin,phenolic compound,Ca2+,SA and JA,activities of PAL and PPO increased in the leaves at different positions treated with glucohexaose.This indicated that glucohexaose could induce system resistance of cucumber to Pseudoperonospora cubensis by accumulating constriction resistance materials,by way of SA and JA transferring disease resistance signal.",
        "keywords": [
            "system signal transduction",
            "cucumber",
            "glucohexaose",
            "constriction resistance",
            "disease resistance",
            "leaves",
            "peroxidase",
            "enzyme activity",
            "enzymes",
            "calcium",
            "signal transduction"
        ],
        "authors": [
            {
                "name": "SUN Yan-qiu",
                "org": "College of Plant Protection,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "LI Bao-ju",
                "org": "Institute of Vegetables and Flowers,CAAS,Beijing ,China"
            },
            {
                "name": "SHI Yan-xia",
                "org": "Institute of Vegetables and Flowers,CAAS,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Jilin Agricultural University",
        "year": 2009
    },
    "99YcAaOS": {
        "id": "99YcAaOS",
        "title": "Construction and Detection of Streptomyces lydicus A01 Transformants with Elicitor Genes from Trichoderma",
        "abstract": "Trichoderma reesei QM 6a is characterized with a high level of XYN2 elicitor,which induces ethylene signaling pathway in plants,while sm1 elicitor produced by Trichoderma virens Gv29-8 is proved to induce jasmonic acid and ethylene signaling pathway.Both the elicitors could enhance the resistance of pathogens in plants.In this study,in order to improve the control effect of fungal pathogens by synergy of natamycin and elicitors,xyn2 and sm1 genes were synthetized according to the codon preference of Streptomyces coelicolor,linked into pIB139 expression vector and identified via enzyme digestion.The positive plasmid pIB139-xyn2(sm1) was transformed to ET12567(pUZ8002) intermediate strain and further into the genome of S.lydicus A01 by conjugal-transformed method, respectively.Then,for higher induce resistanc,S.lydicus A01 transformant with both xyn2 and sm1 was constructed. The results showed that: The three conjugal-transformants(A01-xyn2,A01-sm1,A01-xyn2+sm1) were constructed successfully,and they will have the synergistic effects of antagonism and induced resistance on plant disease.",
        "keywords": [
            "Streptomyces lydicus A01",
            "sm1",
            "xyn2",
            "conjugal-transformants"
        ],
        "authors": [
            {
                "name": "WU Qiong",
                "org": "Laboratory of Southen Urban Agriculture of Ministry of Agriculture/School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Laboratory of Southen Urban Agriculture of Ministry of Agriculture/School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "LI Yingying",
                "org": "Laboratory of Southen Urban Agriculture of Ministry of Agriculture/School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "GAO Shigang",
                "org": "Laboratory of Southen Urban Agriculture of Ministry of Agriculture/School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "YU Chuanjin",
                "org": "Laboratory of Southen Urban Agriculture of Ministry of Agriculture/School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "LI Yaqian",
                "org": "Laboratory of Southen Urban Agriculture of Ministry of Agriculture/School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Chinese Journal of Biological Control",
        "year": 2013
    },
    "Gtve0rfj": {
        "id": "Gtve0rfj",
        "title": "Relations Between Resistance to Maize Sheath Blight and Resistant Enzymes",
        "abstract": "Dynamic changes in activities of peroxidases(POD),phenylalantine ammonia lyases(PAL),polyphenoloxides(PPO) and superoxide dismutases(SOD) in two resistant cultivars and two susceptible ones of maize after inoculating Rhizoctonia solani were analyzed.The results suggested that the increased activities of PAL,POD,PPO in resistant cultivars(Washi 13 and Shenshi28) were higher than those in susceptible cultivars(Yedan13 and Shenshi 29),the peaks for enzyme activities also emerged earlier in resistant cultivar than in susceptible cultivars.As to SOD,its activity usually inclined to increase at first,and then gradually decrease.",
        "keywords": [
            "maize sheath blight",
            "resistance mechanism",
            "enzymes activity"
        ],
        "authors": [
            {
                "name": "LI Rong-hua",
                "org": "School of Environment Science and Safety Engineering,Tianjin University of Technology,Tianjin ,China;College of Plant Protection,Shenyang Agriculture University,Shenyang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Plant Protection,Shenyang Agriculture University,Shenyang ,China;College of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "GAO Zeng-gui",
                "org": "College of Plant Protection,Shenyang Agriculture University,Shenyang ,China"
            },
            {
                "name": "TANG Bao-hong",
                "org": "College of Plant Protection,Shenyang Agriculture University,Shenyang ,China"
            },
            {
                "name": "LIU Jun-hua",
                "org": "College of Plant Protection,Shenyang Agriculture University,Shenyang ,China"
            }
        ],
        "venue": "Journal of Tianjin Normal University (Natural Science Edition)",
        "year": 2005
    },
    "B0DHSDRZ": {
        "id": "B0DHSDRZ",
        "title": "Population Dynamics of Myzus persicae(Homoptera:Aphididae) on Chrysanthemum in the Greenhouse with Special Reference to the Effects of Temperature and Humidity",
        "abstract": "The population dynamics of the green peach aphid,Myzus persicae(Sulzer) on chrysanthemum plants was monitored in the greenhouse in Shanghai in 2007 and its relations with temperature and relative humidity were analyzed.The results indicated that the population dynamics was single peaked,with the peak occuring at 69 days after transplanting.Decision coefficient and correlation analyses indicated that the population dynamics was significantly positively correlated with the mean maximum temperature.The principal component analysis demonstrated that the mean minimum relative humidity,mean maximum relative humidity,mean relative humidity,mean temperature and mean maximum temperature could significantly affect the aphid population.The stepwise regression analysis indicated that the mean maximum temperature and mean relative humidity were the major factors influencing the population dynamics.In conclusion,the mean maximum temperature was the crucial affecting factor for the aphid population on chrysanthemum plants in greenhouse.",
        "keywords": [
            "relative humidity",
            "Myzus persicae",
            "population dynamics",
            "temperature"
        ],
        "authors": [
            {
                "name": "ZHANG Lu-min",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "LIU Zhi-cheng",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "LIU Li-xing",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Shanghai Jiaotong University(Agricultural Science)",
        "year": 2008
    },
    "CNeISR0p": {
        "id": "CNeISR0p",
        "title": "A new sampling device for monitoring the population dynamics of whitefly adults",
        "abstract": "A new sampling device,consisting of a galvanized iron sheet cylinder,a semitransparent plastic basin and a transparent plastic vial,was designed for more effectively monitoring the population dynamics of whitefly adults.When it is used,the cylinder is placed to envelop an individual host plant,and covered with the basin upside down;a hole is opened in the basin's center and the plastic vial lined with thin sticky yellow paper is attached to the hole with its opening downwards.The device is easy and simple to operate and durable.",
        "keywords": [
            "whitefly",
            "sampling device",
            "monitoring",
            "population dynamics"
        ],
        "authors": [
            {
                "name": "ZHANG Lu-min",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China;Shanghai Corporation of Agricultural Means of Production,Shanghai ,China"
            },
            {
                "name": "LIU Zhi-cheng",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "HU Ya-ping",
                "org": "Pudong New District Agro-Technology Extension Center,Shanghai ,China"
            },
            {
                "name": "LIU Li-xing",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Acta Agriculturae Shanghai",
        "year": 2010
    },
    "Ror7ZAU4": {
        "id": "Ror7ZAU4",
        "title": "ANALYSIS OF DIFFERENTIAL PROTEIN EXPRESSION OF REMI MUTANT OF Trichoderma koningii",
        "abstract": "On purpose of expounding the phenotype change of Trichoderma mutant which pro-duces cellulase,protein profiles of T.koningii CICC and its mutant TK-2R-1 were detected by 2-DE.Eight unique spots were found and four of them were identified and their functions by MS-TOF-TOF were connected with growth and metabolization of Trichoderma spp.The research pro-vides a new theoretical basis and methods for the construction of Trichoderma mutant which is used to produce efficient cellulase.",
        "keywords": [
            "Trichoderma koningii.Cellulose.REMI technology.Protein.Two-dimen-sional gel electrophoresis"
        ],
        "authors": [
            {
                "name": "TANG Jun",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Molecular Cell Biology",
        "year": 2009
    },
    "aPZZ9v3i": {
        "id": "aPZZ9v3i",
        "title": "The correlation between maize genetic polymorphisms and endophytic bacteria population in plant roots",
        "abstract": "14 major maize cultivars in Liaoning Province of China were analyzed for their endophytic bacteria population studies.The results showed that Bucillus ssp was the major genera of endophytic bacteria strains isolated from the maize roots,and the minor strains include Enterobacter spp.,Serratia spp., Xanthomonas spp.,and Clavibacter spp.Also,there were degrees of variations between endophytic bacteria isolated from different species of maize cultivars and growth periods.All 14 major maize cultivars were subjected to a random amplified polymorphic DNAs(RAPDs) study,among 90 random primers tested,13 primers were able to generate distinct DNA fragments,in which,72.7% of 139 RAPD fragments were shown results of polymorphism.Furthermore,from the studies of SPSS cluster analysis which conducted on maize cultivars and endophytic bacteria,our results strongly suggest a close relationship between the species and numbers of endophytic bacteria and the genetic background of maize cultivars.",
        "keywords": [
            "random amplified polymorphic DNA",
            "maize",
            "endophytic bacteria",
            "genetic background"
        ],
        "authors": [
            {
                "name": "GAO Zeng-Gui",
                "org": "Plant Protection College,Shenyang Agricultural University,Key Laboratory of North Crop Immunology China\u2032s Ministry of Agriculture,Shenyang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Plant Protection College,Shenyang Agricultural University,Key Laboratory of North Crop Immunology China\u2032s Ministry of Agriculture,Shenyang ,China;Agriculture and Biology College,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "LIU Xian",
                "org": "Plant Protection College,Shenyang Agricultural University,Key Laboratory of North Crop Immunology China\u2032s Ministry of Agriculture,Shenyang ,China"
            },
            {
                "name": "XUE Chun-Sheng",
                "org": "Plant Protection College,Shenyang Agricultural University,Key Laboratory of North Crop Immunology China\u2032s Ministry of Agriculture,Shenyang ,China"
            }
        ],
        "venue": "Acta Ecologica Sinica",
        "year": 2006
    },
    "3vQPqyvw": {
        "id": "3vQPqyvw",
        "title": "Optimization of Fermentation Process for Chlamydospores of Trichoderma asperellum by Response Surface Methodology",
        "abstract": "The response surface methodology(Box-Benhnken Design) was applied to investigate the four major factors(the concentration of soybean cake powder and maize powder used in medium,the volume of glycerol addition added to the medium,loading volume of liquid medium,initial pH value of medium) that have importent effect on the production of chlamydospores of Trichoderma asperellum ZJSX5003.By variance analysis on the experiment results,the influences of the the four factors and their interactions on the production of chlamydospores was investigated.By performing regression analysis and establishing regression equation based on statistics,the optimal fermentation condition was obtained,that as follow:the concentration of soybean cake powder and maize powder used in medium 33.25 g /L,glycerol 8.86ml/L,each 500ml bottles contains 99.35 ml liquid medium,initial pH 3.26.Under the optimal conditions,the yield of chlamydospore is expected to be 9.56\u00d710~7 spores/ml,theoretically.The practical yield of chlamydospores approached 9.84\u00d710~7spores/ml,reached97.07%of the expected value,increased by 69.07%compared with pre-optimization.In order to test its applicability,used a 10L fermentation tank under the optimal condition,the yield of chlamydospore reached up to1.75\u00d710~8 spores/ml,which is better than shake flask fermentation.Further researches of developing microbial inoculum of Trichoderma chlamydospore could be conducted base on this research.",
        "keywords": [
            "Optimize",
            "BBD design of response surface methodology",
            "Chlamydospores Fermentation process",
            "Trichoderma asperellum"
        ],
        "authors": [
            {
                "name": "WU Wei-ping",
                "org": ""
            },
            {
                "name": "CHEN Jie",
                "org": ""
            },
            {
                "name": "LI Ya-qian",
                "org": ""
            },
            {
                "name": "CHEN Li-jie",
                "org": ""
            },
            {
                "name": "DUAN Yu-xi",
                "org": ""
            }
        ],
        "venue": "China Biotechnology",
        "year": 2013
    },
    "nP0CZsyl": {
        "id": "nP0CZsyl",
        "title": "Pathogenicity differentiation of Curvularia lunata",
        "abstract": "Pathogenic type of Curvularia lunata from Heilongjiang,Jilin,Liaoning and Hebei provinces was analyzed.Twenty-six isolates of C.lunata were divided into four groups by differential hosts.High and moderate pathogenic types were distributed in Wafangdiang city in Liaoning province,Gongzhuling city in Jilin province and Baodin city in Hebei province.A significant diversity of C.lunata was found according to the difference of isozymes including esterase,peroxidase,polyphenol oxidase,superoxide dimutase and malate dehydrogenase.The obvious difference in numbers of bands of isozymes were dectcted.",
        "keywords": [
            "differential host",
            "Curvularia lunata",
            "pathogenicity differentiation",
            "isoenzyme"
        ],
        "authors": [
            {
                "name": "XUE Chun-sheng",
                "org": "The Key Laboratory of Northern Crop Disease Immunity of China Ministry of Agriculture,Laboratory of Molecular and Physiological Plant Pathology of Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "XIAO Shu-qin",
                "org": "The Key Laboratory of Northern Crop Disease Immunity of China Ministry of Agriculture,Laboratory of Molecular and Physiological Plant Pathology of Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "ZHAI Yu-hong",
                "org": "School of Agriculture and Biology of Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "GAO Ying",
                "org": "The Key Laboratory of Northern Crop Disease Immunity of China Ministry of Agriculture,Laboratory of Molecular and Physiological Plant Pathology of Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "GAO Zeng-gui",
                "org": "The Key Laboratory of Northern Crop Disease Immunity of China Ministry of Agriculture,Laboratory of Molecular and Physiological Plant Pathology of Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology of Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Acta Phytopathologica Sinica",
        "year": 2008
    },
    "uDstQzAj": {
        "id": "uDstQzAj",
        "title": "Polymorphism of the soluble protein and isozyme in gray leaf spot pathogen of maize",
        "abstract": "Twenty-three isolates of gray leaf spot pathogen,Cercospora zeae-maydis,collected from grow- ing area of Northern China were clustered based on their soluble protein and isozyme profiles obtained through native PAGE in order to base physiologically the pathogen differentiation at protein or isozyme level.A significant diversity of GLS pathogen was found in terms of spectrum change of soluble protein and isozyme including SOD,MDH,PPO,POD,EST and CAT among those strains,and the obvious difference in the numbers of bands and activities of bands with the same Rf value were also detected. Those data strongly supported that isozyme polymorphism could be indicators to reveal the pathogen diver- sity,however there was lack of evidence to show the correlation of isozyme spectrum with pathogen collec- tion location,therefore at least based those enzymes mentioned above,the change of isozymes was unable to represent the difference of pathogen adaptability to environment.The phenomenon was possibly associ- ated with the wider adaptability of the pathogen to environments or other physiological factors probably in- volved in the regulation of pathogen adaptability.",
        "keywords": [
            "isozyme",
            "soluble protein",
            "Gray leaf spot pathogen"
        ],
        "authors": [
            {
                "name": "WANG Gui-qing",
                "org": " School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": " School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of\u3000Plant Protection",
        "year": 2005
    },
    "zB2662Un": {
        "id": "zB2662Un",
        "title": "Effect of different maize germplasms on activities of cell-wall-degrading enzymes from Curvularia lunata",
        "abstract": "It was found that activities of cellulase and pectolytic enzyme produced from Curvularia lunata,were significantly affected when the pathogen inoculated on various maize germplasms with different resistant levels.Isolate 98-07,which inoculated on resistant germplasms for single generation,was induced relatively higher average cellulase activity(7.99 U/mL) than that induced on susceptible germplasms(4.91 U/mL).By consecutively inoculating low pathogenicity isolates C107 and WS18 on resistant inbred line Shen135 for 5 generations,we found that their pathogenicity improved generally as the increase of generations,and simultaneously their cellulase activities were also enhanced(C107\u223632.0%;WS18\u223672.2%).The data indicated that there is a significant correlation between isolate cellulase activities and the changes of its pathogenicity(C107\u2236r=0.916;WS18\u2236r=0.905) induced specifically on resistant germplasms.",
        "keywords": [
            "cell-wall-degrading enzyme",
            "curvularia lunata",
            "pathogenicity",
            "disease resistance",
            "enzyme activity",
            "cellulase",
            "enzymes"
        ],
        "authors": [
            {
                "name": "JIANG Xue",
                "org": "School of Agriculture and Biology,Shanghai JiaoTong University,Key Laboratory of Urban Agriculture%%#South%%#,Ministry of Agriculture,Shanghai ,China"
            },
            {
                "name": "ZHAI Yu-hong",
                "org": "School of Agriculture and Biology,Shanghai JiaoTong University,Key Laboratory of Urban Agriculture%%#South%%#,Ministry of Agriculture,Shanghai ,China"
            },
            {
                "name": "YAN Hong-hai",
                "org": "College of Plant Protection,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "LIU Zhi-cheng",
                "org": "School of Agriculture and Biology,Shanghai JiaoTong University,Key Laboratory of Urban Agriculture%%#South%%#,Ministry of Agriculture,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Shanghai JiaoTong University,Key Laboratory of Urban Agriculture%%#South%%#,Ministry of Agriculture,Shanghai ,China"
            }
        ],
        "venue": "Acta Phytopathologica Sinica",
        "year": 2010
    },
    "e2Rq96Ha": {
        "id": "e2Rq96Ha",
        "title": "Construction and characterization of a normalized full-length cDNA library of Curvularia lunata",
        "abstract": "A normalized full-length cDNA library was constructed with the mycelium of Curvularia lunata,a causal organism of maize leaf spot,by DSN duplex-specific nuclease normalization method combined with SMART(switching mechanism at 5\u2032 end of RNA transcript) technique.This library was characterized by a plaque titer of 1.4\u00d7106 pfu/ mL and a 96.9% recombination ratio,of which the fragment length of inserted average cDNA sequences was above 1.0 kb.The 173 high quality expressed sequence tags(EST) including 5 coting and 168 singlet was obtained from 192 cDNA clones randomly picked.Based on bioinformatics analysis,the full-length cDNA accounted for 57% of total sequences.BLASTx analysis revealed that 81.5% of the EST displayed significant homology to known or unknown genes from GenBank database.",
        "keywords": [
            "cdna library",
            "normalized",
            "curvularia lunata",
            "mycelium",
            "bioinformatics",
            "genes",
            "genetic analysis",
            "dna cloning",
            "expressed sequence tags",
            "genetic markers"
        ],
        "authors": [
            {
                "name": "LIU Tong",
                "org": "School of Agriculture and Biology and Key Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,Shanghai Jiaotong University,Shanghai ,China;School of Agriculture,Heilongjiang Bayi Agricultural University,Daqing ,China"
            },
            {
                "name": "LIU Li-xing",
                "org": "School of Agriculture and Biology and Key Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "LIU Zhi-cheng",
                "org": "School of Agriculture and Biology and Key Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "HOU Ju-mei",
                "org": "School of Agriculture,Heilongjiang Bayi Agricultural University,Daqing ,China"
            },
            {
                "name": "GAO Shi-gang",
                "org": "School of Agriculture and Biology and Key Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "ZHOU Fei-hong",
                "org": "School of Agriculture and Biology and Key Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology and Key Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Acta Phytopathologica Sinica",
        "year": 2010
    },
    "JC4xsS2t": {
        "id": "JC4xsS2t",
        "title": "Production and Regeneration of Trichoderma Strain T23 Protoplast",
        "abstract": "The best conditions for protoplast preparation and regeneration were studied on Trichoderma T23 strain.The course of releasing and regeneration of protoplast was observed.The optimal conditions for protoplast preparation of Trichoderma T23 strain were as follows:24 h mycelium growth time;the content of enzyme is 15 mg/mL;3\uff5e4 h reaction at 30\uff5e35 \u2103.Trichoderma T23 strain releases protoplast through mycelium rupture.Two modes forming irregular outshoot were found to regulate regeneration of T23 protoplast.",
        "keywords": [
            "regeneration",
            "Trichoderma",
            "protoplast",
            "enzymolysis"
        ],
        "authors": [
            {
                "name": "HUANG Yu-qian",
                "org": "College of Plant Protection,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "LIANG Chun-hao",
                "org": "Institute of Plant Protection,Liaoning Academy of Agricultural Sciences,Shenyang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Plant Protection,Shenyang Agricultural University,Shenyang ,China;College of Agriculture and Biology Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Jilin Agricultural University",
        "year": 2007
    },
    "BcEUfMYx": {
        "id": "BcEUfMYx",
        "title": "Construction and Identification of Streptomyces lydicus A01 Transformed with Elicitor Gene Flagellin from Acidovorax avenae Strain N1141",
        "abstract": "Streptomyces lydicus A01 produces natamycin,which inhibit the growth of fungi through specifically binding to ergosterol of fungal cell membrane.Flagellin,expressed by Acidovorax avenae strain N1141,possesses the abilities of inducing reactive oxygen species(ROS)and activating salicylic acid(SA)signal pathway in plants.In this study,we cloned flagellin gene from Acidovorax avenae strain N1141,transformed it into S.lydicus A01 using conjugation methods,and detected it by PCR analysis.The results showed that positive engineered strain containing flagellin gene was successfully established and the construction of Streptomyces lydicus with flagellin gene could achieve the synergic effects of anti-fungus and induced resisance.This technology showed potential advantage of promoting anti-fungus function in plants.",
        "keywords": [
            "Streptomyces lydicus A01",
            "A01-flagellin conjugal transformant",
            "flagellin gene from Acidovorax avenae strain N1141"
        ],
        "authors": [
            {
                "name": "WU Qiong",
                "org": "Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "LIN Zhen-ya",
                "org": "Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "LI Ying-ying",
                "org": "Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "LI Ya-qian",
                "org": "Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "GAO Shi-gang",
                "org": "Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Shanghai Jiaotong University(Agricultural Science)",
        "year": 2013
    },
    "SjqEuopl": {
        "id": "SjqEuopl",
        "title": "Elicitor hydrophobin Hyd1 interacts with Ubiquilin1-like to induce maize systemic resistance.",
        "abstract": "Trichoderma harzianum is a plant-beneficial fungus that secretes small cysteine-rich proteins that induce plant defense responses; however, the molecular mechanism involved in this induction is largely unknown. Here, we report that the class II hydrophobin ThHyd1 acts as an elicitor of induced systemic resistance (ISR) in plants. Immunogold labeling and immunofluorescence revealed ThHyd1 localized on maize (Zea mays) root cell plasma membranes. To identify host plant protein interactors of Hyd1, we screened a maize B73 root cDNA library. ThHyd1 interacted directly with ubiquilin 1-like (UBL). Furthermore, the N-terminal fragment of UBL was primarily responsible for binding with Hyd1 and the eight-cysteine amino acid of Hyd1 participated in the protein-protein interactions. Hyd1 from T. harzianum (Thhyd1) and ubl from maize were co-expressed in Arabidopsis thaliana, they synergistically promoted plant resistance against Botrytis cinerea. RNA-sequencing analysis of global gene expression in maize leaves 24 hours after spraying with Curvularia lunata spore suspension showed that Thhyd1-induced systemic resistance was primarily associated with brassinosteroid signaling, likely mediated through BAK1. Jasmonate/ethylene (JA/ET) signaling was also involved to some extent in this response. Our results suggest that the Hyd1-UBL axis might play a key role in inducing systemic resistance as a result of Trichoderma-plant interactions.",
        "keywords": "",
        "authors": [
            {
                "name": "Chuanjin Yu",
                "org": "State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, 200240, China."
            },
            {
                "name": "Kai Dou",
                "org": "State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, 200240, China."
            },
            {
                "name": "Shaoqing Wang",
                "org": "State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, 200240, China."
            },
            {
                "name": "Qiong Wu",
                "org": "State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, 200240, China."
            },
            {
                "name": "Mi Ni",
                "org": "State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, 200240, China."
            },
            {
                "name": "Tailong Zhang",
                "org": "State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, 200240, China."
            },
            {
                "name": "Zhixiang Lu",
                "org": "State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, 200240, China."
            },
            {
                "name": "Jun Tang",
                "org": "School of Life Science, Fuyang Normal University, Fuyang 236037, China."
            },
            {
                "name": "Jie Chen",
                "org": "State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai, 200240, China."
            }
        ],
        "venue": "Journal of integrative plant biology",
        "year": 2019
    },
    "Bb5nogXs": {
        "id": "Bb5nogXs",
        "title": "Cloning and functional analysis of Clm1 in Curvularia lunata",
        "abstract": "A full-length of Clm1 gene from Curvularia lunata was cloned,which was highly homologous to the mitogen-activated protein(MAP) kinase ChMps1 in Cochliobolus heterostrophus.The whole sequence and flanking regions of Clm1 was amplified by Inverse PCR and RACE.Its full-length cDNA is 1.251 kb,encoding 416 amino acid residues.The targeted disruption of Clm1 was obtained by Agrobacterium-mediated transformation.Furthermore,it was found that the Clm1 mutants had impaired cell wall and caused low production of conidiospores,deformed spore formation and decreased disease symptoms on maize leaves.In addition,the Clm1 mutants also had an effect on the activity of cellulase.The results above were indicated that Clm1 played an important role in the cell wall integrity and pathogenicity in C.lunata.",
        "keywords": [
            "MAPK",
            "Curvularia lunata",
            "Clm1"
        ],
        "authors": [
            {
                "name": "WANG Jia-yuan",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Key Laboratory of Urban Agriculture%%#South%%#,Ministry of Agriculture,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Key Laboratory of Urban Agriculture%%#South%%#,Ministry of Agriculture,Shanghai ,China"
            }
        ],
        "venue": "Acta Phytopathologica Sinica",
        "year": 2011
    },
    "FLYQ476U": {
        "id": "FLYQ476U",
        "title": "Optimization of Fermentation Conditions of Collaborative Expression of Chitinase and Natamycin from Streptomyces lydicus A01-chit33 CT",
        "abstract": "Biological control of plant diseases is an effective method with the beneficial microorganisms or microbial metabolites against crop diseases.Streptomyces are already identified to produce a range of antibiotics including natamycin etc.,which exhibit an excellent activities against fungal pathogens.Streptomyces lydicus A01 has been proved as a biocontrol microbe with antagonistic activity against Botrytis cinerea by producing natamycin,which degrading the cell membrane of fungal pathogens.Natamycin,a polyene macrolide antibiotic with broad-spectrum antifungal activity,has a stable and strong inhibitory activity against many plant pathogenic fungi,and is commonly used as antifungal agent.Chitinase can degrade chitin and could be used for resist many fungal pathogens.In A01-chit33CT,natamycin was produced to inhibit plant pathogens via destructing fungal cell membrane,while chit33 plays an important role in hydrolyzing the chitin component in fungal pathogen cell wall.The coordination effect of natamycin and chit33 may be improved significantly. The optimal fermentation conditions for chitinase activity and natamycin produced in Streptomyces lydicus A01-chit33CT were studied.Firstly,the effect of different carbon and nitrogen sources on natamycin production and chitinase activities were investigated.The results showed that: glucose can promote natamycin production but inhibit the expression of chit33,so glucose and chitin powder were added into the fermentation medium with two-stage method to achieve collaborative expressions of both.The optimal medium compositions were as follow: chitin powder 10 g/L(after 4 days),glucose 40 g/L,soybean meal 30 g/L,soya peptone 10 g/L,CaCO3 5g/L,MgSO4\u00b77H2O 0.5g/L,K2HPO4 0.5 g/L.Secondly,the cultural conditions were further to optimum as follows: initial pH 6.0,temperature 28\u2103,rotation speed 180 r/min.The highest natamycin production could reach 1.52 g/L and chitinase activity reach 990U/ml under the optimal fermentation conditions.Both levels improved by 1.95 and 2.27 times at post-optimazation compared to that of pre-optimization,respectively.",
        "keywords": [
            "Streptomyces lydicus A01-chit33CT Natamycin Chitinase Fermentation Optimization"
        ],
        "authors": [
            {
                "name": "LIN Zhen-ya",
                "org": "Key Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture & Biology, Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "WU Qiong",
                "org": "Key Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture & Biology, Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "SUN Rui-yan",
                "org": "Key Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture & Biology, Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Key Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture & Biology, Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "LI Ya-qian",
                "org": "Key Laboratory of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture & Biology, Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "China Biotechnology",
        "year": 2012
    },
    "cDizVYFR": {
        "id": "cDizVYFR",
        "title": "Inflence of Toxin By Curvularia lunata on Superoxidation of Membrane Lipid in Corn Cell",
        "abstract": "Superoxidation of membrane lipid in corn leaf cells had been studied by researching the contert of MDA under toxin stress. The results of experiment showed that the content MDA ascended in compatible combination, the permeability of corn cell membrane had increased. There were positive correlation between toxin effect and time exposure to toxin. This indicated that the toxin destroyed the permeability of corn cell membrane.",
        "keywords": [
            "MDA",
            "Toxin",
            "Curvularia lunata",
            "Superoxidation of membrane lipid"
        ],
        "authors": [
            {
                "name": "TANG Shu-ge",
                "org": " Shenyang Agricultural Univercity, Shenyang "
            },
            {
                "name": "WANG Fen",
                "org": ""
            },
            {
                "name": "GAO Zeng-gui",
                "org": " Shenyang Agricultural Univercity, Shenyang "
            },
            {
                "name": "ZHUANG Jing-hua",
                "org": " Shenyang Agricultural Univercity, Shenyang "
            },
            {
                "name": "CHEN Jie",
                "org": " Shanghai Jiaotong Univercity, Shanghai , China"
            }
        ],
        "venue": "Journal of Maize Sciences",
        "year": 2007
    },
    "Q8RmV70L": {
        "id": "Q8RmV70L",
        "title": "Proteomics related to resistance to the cucumber powdery mildew disease in F2 generation of cucumber",
        "abstract": "Proteomic approaches using two-dimensional gel electrophoresis (2-DE) were adopted to identify proteins from cucumber leaves differentially expressed in F2 generation of cucumber. Nearly 500 proteins were reproducibly detected, including 39 specific proteins expressed in F2 sensitive pool samples and 22 specific proteins expressed in resistance pool samples, 35 proteins were two-fold upper limit and 46 proteins were two-fold lower limit. Furthermore, analysis with MALD1-TOF-MASS showed that one important protein of disease resistance gene (SSP3110) identified in F2 generation of cucumber associated with defensive reaction. Three proteins (SSP5412, SSP5513, SSP5710) related to respiration or photosynthesis were identified in F2 resistant pool samples, and 14-3-3 brain protein homolog (SSP1411) was identified in F2 sensitive pool samples. All those proteins were probably parts of network of resistance or development-related proteins. This study gives new insights into cucumber powdery mildew resistant response in cucumber leaves and demonstrates the power of the proteomic approach in plant biology studies. MS analysis of other protein spots is underway.",
        "keywords": [
            "Cucumber",
            "Mass spectrometry",
            "Powdery mildew",
            "Proteomics"
        ],
        "authors": [
            {
                "name": "Haiyan Fan",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Shufa F. Xu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Jie Chen",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Gen W. Cheng",
                "org": "Shenyang Agricultural University(Shenyang Agricultural University),Shenyang,China"
            },
            {
                "name": "Xiuli Huang",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Xiaofei Wang",
                "org": "Shenyang Agricultural University(Shenyang Agricultural University),Shenyang,China"
            }
        ],
        "venue": "Journal of Shanghai Jiaotong University (Science)",
        "year": 2005
    },
    "t7mITCkp": {
        "id": "t7mITCkp",
        "title": "Effect of Maize Head Smut Pathology(Sphacelotheca reiliana) on the Major Defensive Enzymes of Host",
        "abstract": "Maize head smut caused by Sphacelotheca reiliana is a important disease in corn,which causes serious losses in yield.The inoculation of pathology could activated the activities of defensive enzymes in corn.The results suggested that activities of PAL,SOD,PPO and EST were increased after inoculating regardless of in resistant cultivars or susceptible cultivars,and the enzyme activities in resistant cultivar of Xintie10 were higher than those of susceptible cultivar of Shendan16.However,the activities of POD and CAT were lower in resistant cultivar of Xintie10 than those in susceptible cultivar of Shendan16.Resistance of the different corn cultivars was significantly correlated with the defensive enzymes in adult stage.",
        "keywords": [
            "Defensive enzymes",
            "Host",
            "Maize",
            "Sphacelotheca reiliana"
        ],
        "authors": [
            {
                "name": "HE Zi-dian",
                "org": "Agronomy Department,Hebei Science Technology Normal College,Hebei Qinhuangdao "
            },
            {
                "name": "GAO Zeng-gui",
                "org": "Agronomy Department,Hebei Science Technology Normal College,Hebei Qinhuangdao "
            },
            {
                "name": "ZHUANG Jing-hua",
                "org": "Agronomy Department,Hebei Science Technology Normal College,Hebei Qinhuangdao "
            },
            {
                "name": "CHEN Jie",
                "org": "Agriculture and Biology College,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "ZHENG Jun-qiang",
                "org": "Agronomy Department,Hebei Science Technology Normal College,Hebei Qinhuangdao "
            },
            {
                "name": "TANG Shu-ge",
                "org": "Agronomy Department,Hebei Science Technology Normal College,Hebei Qinhuangdao "
            }
        ],
        "venue": "Journal of Maize Sciences",
        "year": 2006
    },
    "YmH3VLJd": {
        "id": "YmH3VLJd",
        "title": "Impact on bacterial community in midguts of the Asian corn borer larvae by transgenic Trichoderma strain overexpressing a heterologous chit42 gene with chitin-binding domain.",
        "abstract": "This paper is the first report of the impact on the bacterial community in the midgut of the Asian corn borer (Ostrinia furnacalis) by the chitinase from the transgenic Trichoderma strain. In this study, we detected a change of the bacterial community in the midgut of the fourth instar larvae by using a culture-independent method. Results suggested that Proteobacteria and Firmicutes were the most highly represented phyla, being present in all the midgut bacterial communities. The observed species richness was simple, ranging from four to five of all the 16S rRNA clone libraries. When using Trichoderma fermentation liquids as additives, the percentages of the dominant flora in the total bacterial community in larval midgut changed significantly. The community of the genus Ochrobactrum in the midgut decreased significantly when the larvae were fed with the fermentation liquids of the transgenic Trichoderma strain Mc4. However, the Enterococcus community increased and then occupied the vacated niche of the Ochrobactrum members. Furthermore, the Shannon-Wiener (H) and the Simpson (1-D) indexes of the larval midgut bacterial library treated by feeding fermentation liquids of the transgenic Trichoderma strain Mc4 was the lowest compared with the culture medium, fermentation liquids of the wild type strain T30, and the sterile artificial diet. The Enterococcus sp. strain was isolated and characterized from the healthy larvae midgut of the Asian corn borer. An infection study of the Asian corn borer larvae using Enterococcus sp. ACB-1 revealed that a correlation existed between the increased Enterococcus community in the larval midgut and larval mortality. These results demonstrated that the transgenic Trichoderma strain could affect the composition of the midgut bacterial community. The change of the midgut bacterial community might be viewed as one of the factors resulting in the increased mortality of the Asian corn borer larvae.",
        "keywords": [
            "biology",
            "chemistry",
            "up regulation",
            "bacteria",
            "lepidoptera",
            "larva",
            "physics",
            "phylogeny",
            "fermentation",
            "engineering",
            "transgenes",
            "medicine",
            "gene library"
        ],
        "authors": [
            {
                "name": "Yingying Li",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Kehe Fu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Shigang Gao",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Qiong Wu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Lili Fan",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Yaqian Li",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Jie Chen",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            }
        ],
        "venue": "PloS one",
        "year": 2013
    },
    "3DU0jszv": {
        "id": "3DU0jszv",
        "title": "Influence of Cercospora zeae-maydis toxin on defense enzyme activities and its function in the induced resistance of corn",
        "abstract": "\u3010Objective\u3011 The purpose was to study mechanism and effect of C.zeae-maydis toxin to resistant and susceptible inbred lines.\u3010Method\u3011 Activity of defense enzyme(PAL,POD,PPO,CAT and SOD)and area of disease leaf were detected.\u3010Result\u3011 PAL,POD and PPO activity were higher in resistant by toxin inbred lines than in susceptible ones,but on the contrary,the lower activities of CAT and SOD were found in resistant inbred lines when treated with toxin compared with that in susceptible ones.In addition,the research showed that function of induced resistance in resistant inbred lines was higher in susceptible one.\u3010Conclusion\u3011 Toxin of C.zeae-maydis induced resistance to corn gray leaf spot.",
        "keywords": [
            "toxin",
            "defense enzyme",
            "Cercospra zeae-maydis",
            "induced resistance"
        ],
        "authors": [
            {
                "name": "XUE Chun-sheng",
                "org": " The Key Laboratory of Northern Crop Disease Immunity of China Ministry of Agriculture,Laboratory of Molecular and Physiological Plant Pathology of Shenyang Agricultural University,Shenyang,Liaoning ,China"
            },
            {
                "name": "XIAO Shu-qin",
                "org": " The Key Laboratory of Northern Crop Disease Immunity of China Ministry of Agriculture,Laboratory of Molecular and Physiological Plant Pathology of Shenyang Agricultural University,Shenyang,Liaoning ,China"
            },
            {
                "name": "HAN Hong-qiang",
                "org": " School of Agriculture and Biology of Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "GAO Ying",
                "org": " The Key Laboratory of Northern Crop Disease Immunity of China Ministry of Agriculture,Laboratory of Molecular and Physiological Plant Pathology of Shenyang Agricultural University,Shenyang,Liaoning ,China"
            },
            {
                "name": "CHEN Jie",
                "org": " School of Agriculture and Biology of Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Northwest A & F University(Natural Science Edition)",
        "year": 2008
    },
    "G5z5JCIC": {
        "id": "G5z5JCIC",
        "title": "Research into the Characteristics of Different Cultures of Sporisorium reiliana",
        "abstract": "The characteristics of the maize head smut fungi(Sporisorium reiliana) change in different cultures,whether on the PDA or in the PD.Based on the PDA culture differentiation,23 strains could be divided into 6 groups.Based on the color difference of PD colony,23 strains could be divided into 4 groups.And based on the pathogenesis strength,23 strains could be divided into 7 groups.It showed the germ pathogenesis strength has a positive relationship to the depth of pigment.",
        "keywords": [
            "characteristics",
            "Maize head smut fungi(Sporisorium reiliana)",
            "culture differentiation"
        ],
        "authors": [
            {
                "name": "HE Zi-dian",
                "org": " Dept of Agricultural,HNUST,Qinhuangdao Hebei,"
            },
            {
                "name": "CHEN Jie",
                "org": " College of Agriculture and Biology,Shanghai Jiaotong University"
            },
            {
                "name": "GAO Zeng-gui",
                "org": " Key Laboratory of Northern Crop Immunology,China's Ministry of Agriculture,Shenyang Agricultural University"
            },
            {
                "name": "ZHUANG Jing-hua",
                "org": " Key Laboratory of Northern Crop Immunology,China's Ministry of Agriculture,Shenyang Agricultural University"
            }
        ],
        "venue": "Journal of Hebei Normal University of Science & Technology",
        "year": 2006
    },
    "VGwOLeQD": {
        "id": "VGwOLeQD",
        "title": "Progress on Mechanism and Applications of Trichoderma as a Biocontrol Microbe",
        "abstract": "Trichoderma is widely used as a biocontrol microbe against plant diseases in the world,which is mainly applied for controlling a variety of soil borne plant diseases and some plant aboveground diseases.With the advent of MAMPs(microbe-associated molecular patterns) theory,the study on mechanism of plant disease control and improved plant resistance to stress factors with Trichoderma as a biocontrol agent has come into a new stage,especially as the development of technologies based on systems biology,it has become possible to understand the nature of interaction of plant-Trichoderma-pathogen from point of \"omics\" view,which therefore would intensively enrich the theory basis of Trichoderma as biocontrol agent.Meanwhile,a diversified technical system for applying Trichoderma products developed in national agricultural industry would provide great promotion to sustainable development of agriculture in the future.This review will focus on new research progress on biocontrol mechanism with Trichoderma against plant diseases at molecular level.",
        "keywords": [
            "biocontrol",
            "MAMPs",
            "Trichoderma",
            "plant disease"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai ,China"
            },
            {
                "name": "ZHU Jie-wei",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai ,China"
            },
            {
                "name": "ZHANG Ting",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai ,China"
            },
            {
                "name": "WANG Bing-li",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai ,China"
            }
        ],
        "venue": "Chinese Journal of Biological Control",
        "year": 2011
    },
    "oqiWIdef": {
        "id": "oqiWIdef",
        "title": "Selection of endophytic bacteria for suppression of corn sheath blight caused by Rhizoctonia solani",
        "abstract": "Two hundred and thirty-two strains of endophytic bacteria were isolated from corn root,stem tissues during adult period.By way of in vitro screening,20 antagonistic strains against Rhizoctonia solani (7 strains Bacillus subtilis,about 35% of the total antagonistic strains screened) were gotten.Among the 20 strains,6 strains (B20-120,B20-006,B20-122,B21-072,B21-016,B20-070 ) had been proved that their fermented solution did not inhibit corn seed germination.Endophytic detection (tagged by the resist- ance to Rif,120 mg\u00b7mL~(-1)) of the 6 strains,their growth-promoting effects on corn,and control effects against corn sheath blight were studied.The results showed that these strains could live,and transfer in corn plant,while the growth-promoting effect of the strains on corn was evident.Two strains,B20-006 and B20-120 ,were efficient biological control agents to control corn sheath blight.Seed coating with 2 strains cultures gave 67.9% and 62.3% control efficacies at seedling stage,40.2% and 39.1% at adult stage, respectively.",
        "keywords": [
            "endophytic detection",
            "biological control",
            "promotion effect",
            "antagonistic bacteria",
            "Corn sheath blight"
        ],
        "authors": [
            {
                "name": "GAO Zeng-gui",
                "org": " Agricuhure and Biology College,Shanghai Jiaotong University.Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": " Agricuhure and Biology College,Shanghai Jiaotong University.Shanghai ,China"
            },
            {
                "name": "FENG Jing",
                "org": " Agricuhure and Biology College,Shanghai Jiaotong University.Shanghai ,China"
            },
            {
                "name": "ZHUANG Jing-hua",
                "org": " Agricuhure and Biology College,Shanghai Jiaotong University.Shanghai ,China"
            },
            {
                "name": "LIU Jun-hua",
                "org": " Agricuhure and Biology College,Shanghai Jiaotong University.Shanghai ,China"
            }
        ],
        "venue": "Journal of\u3000Plant Protection",
        "year": 2005
    },
    "P5lpsRLk": {
        "id": "P5lpsRLk",
        "title": "Proteomics associated with virulence differentiation of Curvularia iunata in maize in China",
        "abstract": "One-dimensional electrophoresis (1-DE) of proteins, two-dimensional electrophoresis (2-DE) of proteins and cloning of cDNA sequence were used to study the virulence differentiation of Curvularia lunata (Wakker) Boed. isolated from maize (Zea maydis L.) in China. From 1-DE gel profiles of proteins, 110 reproducible bands were separated from six isolates of C. lunata CX-3, SD-6, C-152, C107-1, DD-60 and W-18. Sixty-eight bands (61.82%) were polymorphic, suggesting huge biodiversities among the isolates. All isolates for the experiment were clustered into three groups consisting of different virulent types by coefficient value of 0.605. Group 1, consisting of CX-3, SD-6 and C-152 with high virulence displayed more protein bands than Groups 2 and 3, consisting of C107-1 and DD-60 with low virulence. Proteomics approaches based on 2-DE techniques were applied to identify specific proteins associated with the virulence differentiation in CX-3 and DD-60. A total of 423 protein spots were separated. Out of them 75 specific protein spots were displayed in 2-DE gels. Among them 28 protein spots were unique in CX-3 and eight in DD-60, and 39 protein spots were shown on both 2-DE gels but expressed differently in intensity. Twenty protein spots including three unique protein spots and 17 differentially expressed protein spots (more than two-fold DD-60) in CX-3 were further identified with MALDI-TOF MS/MS. Results indicated that most of the identified proteins were found to be associated with virulence differentiation, metabolisms, stress response and signal transduction. One of them was identified as Brn1 protein, which had been reported to be related to melanin biosynthesis and the virulence differentiation in fungi. Combined with our previous findings, we assumed that Brn1 protein and its regulating products might be involved in the virulence differentiation of C. lunata. Consequently, we cloned a Brn1 cDNA fragment and aligned it with the fragments in other fungi. Results indicated that the 633-bp sequence of Brn1 cloned in C. lunata was highly homological with the compared fungi. Further work for the exact gene roles of Brn1 in our case is underway. \u00a9 2007 Institute of Botany, the Chinese Academy of Sciences.",
        "keywords": [
            "Brn1 cDNA fragment",
            "Curvularia lunata",
            "Mass spectrometry",
            "Proteomics",
            "Two-dimensional electrophoresis",
            "Virulence differentiation",
            "Zea maydis"
        ],
        "authors": [
            {
                "name": "Shufa F. Xu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Jie Chen",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Lixing Liu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Xiaofei Wang",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Xiuli Huang",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Yuhong Zhai",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            }
        ],
        "venue": "Journal of Integrative Plant Biology",
        "year": 2007
    },
    "q1LIhDaE": {
        "id": "q1LIhDaE",
        "title": "Co-culture of <Emphasis Type=\"Italic\">Bacillus amyloliquefaciens</Emphasis> ACCC11060 and <Emphasis Type=\"Italic\">Trichoderma asperellum</Emphasis> GDFS1009 enhanced pathogen-inhibition and amino acid yield",
        "abstract": "Bacillus spp. are a genus of biocontrol bacteria widely used for antibiosis, while Trichoderma spp. are biocontrol fungi that are abundantly explored. In this study, a liquid co-cultivation of these two organisms was tried firstly.",
        "keywords": [
            "Bacillus amyloliquefaciens",
            " Trichoderma asperellum",
            " Liquid co-cultivation",
            " Amino acid",
            " Biocontrol metabolites"
        ],
        "authors": [
            {
                "name": "Qiong\u00a0Wu",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai,China"
            },
            {
                "name": "Mi\u00a0Ni",
                "org": "Anhui Province Key Laboratory of Embryo Development and Reproductive Regulation, Anhui Province Key Laboratory of Environmental Hormone and Reproduction,Fuyang Normal University,Fuyang,China"
            },
            {
                "name": "Kai\u00a0Dou",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai,China"
            },
            {
                "name": "Jun\u00a0Tang",
                "org": "Anhui Province Key Laboratory of Embryo Development and Reproductive Regulation, Anhui Province Key Laboratory of Environmental Hormone and Reproduction,Fuyang Normal University,Fuyang,China"
            },
            {
                "name": "Jianhong\u00a0Ren",
                "org": "Suzhou BioNovoGene Metabolomics Platform,Suzhou,China"
            },
            {
                "name": "Chuanjin\u00a0Yu",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai,China"
            },
            {
                "name": "Jie\u00a0Chen",
                "org": "School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai,China"
            }
        ],
        "venue": "Microbial Cell Factories",
        "year": 2018
    },
    "QoCnd8ai": {
        "id": "QoCnd8ai",
        "title": "Effect of Salinity on the Biocontro Trichoderma Strain SH2303",
        "abstract": "The effects of a range of salinity concentrations on growth rate,hyphae weight,the production of conidiospore and chlamydospore,and chitinase activities of Trichoderma strain SH2303 were investigated,and the antagonistic variation against Fusarium oxysporum f.sp.cucumerinum in co-culture test with Trichoderma strain SH2303 was conducted.The results showed that as salinity increased,the growth rate,hyphae weight,production of conidiospore and chlamydospore of Trichoderma strain SH2303 were inhibited more progressively.The quantity of produced conidiospore and chlamydospore with salt significantly reduced compare to without salt.No significant effects of salinity on inhibiting function of Trichoderma to cucumber fusarium wilt.",
        "keywords": [
            "cucumber fusarium wilt",
            "biological control",
            "Trichoderma",
            "salinity"
        ],
        "authors": [
            {
                "name": "LIN Zhen-ya",
                "org": "Key Lab of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture & Biology, Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "MA Jia",
                "org": "Key Lab of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture & Biology, Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "YI Si-yao",
                "org": "Key Lab of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture & Biology, Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "LI Ya-qian",
                "org": "Key Lab of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture & Biology, Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Key Lab of Urban Agriculture%%#South%%# of Ministry of Agriculture,School of Agriculture & Biology, Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Shanghai Jiaotong University(Agricultural Science)",
        "year": 2012
    },
    "nBNySgSr": {
        "id": "nBNySgSr",
        "title": "Improved phytoremediation of oilseed rape (Brassica napus) by Trichoderma mutant constructed by restriction enzyme-mediated integration (REMI) in cadmium polluted soil.",
        "abstract": "In this study, oilseed rape (Brassica napus) was exploited in remediation of Cd-contaminated soil in combination of Trichodermakoningii. To improve its phytoextracting efficiency, restriction enzyme-mediated integration was used to construct Trichoderma mutants with higher Cd resistance. Of 200 mutants, 10 mutants were shown with higher Cd tolerance and enhanced ability of removing Cd from growth medium. In pot experiment, mutant P6 significantly alleviated the negative impacts of Cd on oilseed rape growth, and improved the Cd uptake ability of oilseed rape shoot in Cd contaminated soil (p<0.05). Based on the dry weight, the amounts of Cd in shoots of mutant P6 treated oilseed rape were increased by 23% and 38% per pot compared with wild type Trichoderma treatment; 53% and 107% against non-inoculated treatment, respectively, at 20 and 50mgCdkg(-1) soil. The results suggested the Trichoderma mutant-oilseed rape symbiosis system could be used in remediation of soil contaminated with heavy metal Cd.",
        "keywords": [
            "oilseed rape",
            "trichoderma",
            "remi",
            "bioremediation",
            "cadmium"
        ],
        "authors": [
            {
                "name": "Bing Wang",
                "org": "Department of Resource and Environmental Science, School of Agriculture and Biology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, Shanghai Jiaotong University, Shanghai 200240, China"
            },
            {
                "name": "Lixing Liu",
                "org": ""
            },
            {
                "name": "Yongdong Gao",
                "org": "Department of Resource and Environmental Science, School of Agriculture and Biology, Key Laboratory of Urban Agriculture (South), Ministry of Agriculture, Shanghai Jiaotong University, Shanghai 200240, China"
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Chemosphere",
        "year": 2009
    },
    "MyN3eSpY": {
        "id": "MyN3eSpY",
        "title": "Advance in research of proteomics related to several maize diseases",
        "abstract": "Progress in resistance-related proteins of several maize diseases including ear rot caused by Fusa-rium oxysporum,Aspergillus flavusa and A.parasiticus,seedling damping-off caused by Pythium ultimum was introduced as well as in virulence-related proteins and host resistance-related proteins of Curvularia leaf spot induced by Curvularia lunata.Moreover the advantages and major areas of proteomics technique to deal with the interaction of maize-pathogen were deeply discussed.",
        "keywords": [
            "mass spectrum analysis",
            "proteomics",
            "pathogenicity differentiation",
            "maize disease"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "XU Shu-fa",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "HUANG Xiu-li",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "LIU Li-xing",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "CHEN Yun-peng",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Acta Phytopathologica Sinica",
        "year": 2007
    },
    "nAGDrVAY": {
        "id": "nAGDrVAY",
        "title": "Generation and identification of DNA sequence flanking T-DNA integration site of Trichodermaatroviride mutants with high dichlorvos-degrading capacity",
        "abstract": "A protocol for efficient Agrobacterium tumefaciens -mediated transformation (ATMT) of biocontrol fungus Trichoderma atroviride strain T23 was developed to construct mutants with improved dichlorvos-degradation ability. A transformation frequency of 5 \u00d7 10 \u22126 was achieved. Among 110 genetically stable T-DNA transformants of T . atroviride T23, two transformants, AMT-12 and AMT-28, confirmed by Southern blot analysis to have single-copy inserts of T-DNA, showed an increase in dichlorvos-degradation ability of more than 10% compared to that of the wild type, exhibited similar tolerance to the pesticide, but lower spore formation ability. Five transformants exhibited a reduction in degradation of more than 70%, exhibited wild-type spore formation, and tolerated up to 800 \u03bcg/mL of dichlorvos. The left-flanking sequence of the insertion site in AMT-12 was cloned as a 1845-bp fragment and shown to have 89% identity to the DNA from T . atroviride IMI 206040; however, the involvement of this DNA in dichlorvos degradation remains still to be determined. This study can promote both a more efficient isolation of DNA sequence flanking T-DNA integration site in T . atroviride mutants and a more rational utilization of these transformants in dichlorvos degradation. Keywords ATMT Trichoderma atroviride Dichlorvos Microbial degradation 1 Introduction Organophosphorus pesticides are one of the most widely used agricultural chemical globally and their consumption accounts for 34% of the total sales of the insecticides every year ( Singh and Walker, 2006 ). Dichlorvos (O-2, 2-dichlorovinyl-O, O-dimethyl phosphate, C 4 H 7 O 4 Cl 2 P) is an efficient broad-spectrum organophosphate pesticide with medium toxicity. In the past two decades, dichlorvos has been widely applied to control pests of plants, homes and grain depots. Since dichlorvos has a relatively high water solubility, it is frequently detected as a major organic pollutant in surface, coastal and even ground water ( Zhang et al., 2002; Li et al., 2005 ) and poses a threat to health ( Bolton-Warberg et al., 2007 ). Therefore, the development of innovative technologies for the rapid degradation of dichlorvos is highly desired. Some Trichoderma species have the ability to degrade organophosphorus pesticides, such as dichlorvos, chlorpyrifos and glyphosate. These Trichoderma strains were usually isolated from natural environments ( Fu and Guo, 2006; Zhang et al., 2006 ). Their isolation was often time-consuming and the degradation efficiencies of isolated strains were low. These shortcomings limited further investigation to determine the underlying molecular mechanisms of organophosphorus pesticides degradation by Trichoderma species. To date, twelve genes involved in degradation of organophosphorus compounds have been cloned including the organophosphorus-degrading gene, opd , from Pseudomonas diminuta ( Singh and Walker, 2006 ); however, the isolation of the corresponding genes to opd from Trichoderma species has not yet been reported. Agrobacterium tumefaciens -mediated transformation (ATMT) is one of the most frequently used methods for introducing exogenous DNA into filamentous fungi ( de Groot et al., 1998 ), this technique exhibits many intrinsic advantages including low copy number of DNA insertions, improved targeted integration and non-specific recipient cell types (spores, germlings and hyphal tissue) ( Meyer, 2008 ). Trichoderma atroviride has been extensively investigated due to its potential as a biological control agent. Zeilinger (2004) employed a modified ATMT method for the efficient disruption of two genes encoding signaling compounds of the T . atroviride strain P1. Comparison of the phenotypic and genetic stability of recombinant T . atroviride strain T11 generated by protoplast-mediated transformation and ATMT was conducted ( Cardoza et al., 2006 ). Recently, Tang et al. (2009) reported that T. atroviride strain T23 had the ability to degrade dichlorvos. Here, we describe an optimized ATMT procedure for T. atroviride strain T23 with the goal of obtaining transformants with improved dichlorvos-degradation capacity. Furthermore, an in vitro cloning method based on PCR technique was used to efficiently isolate the left-flanking sequence of the T-DNA integration site of targeted transformants. Overall, the aim was to facilitate the cloning of genes involved in degradation of dichlorvos in T . atroviride strain T23. 2 Methods 2.1 Strains and plasmids T . atroviride T23, isolated from cucumber rhizosphere in a vegetable field of Shenyang (China) was used for ATMT. The strain A . tumefaciens AGL-1 containing the binary vector pBHt1 ( Mullins et al., 2001 ), which has a hygromycin B-resistance gene ( hph ) driven by the Aspergillus nidulans gpd promoter and trp C terminator, was kindly provided by Prof. Jingao Dong (Hebei Agricultural University, China). 2.2 Transformation ATMT of strain T23 was based on previous protocols ( de Groot et al., 1998; Covert et al., 2001 ) with modifications. A fresh colony of A . tumefaciens strain AGL-1 containing pBHt1 was cultured at 28 \u00b0C for 2 d with shaking at 240 rpm in LB broth supplemented with 50 \u03bcg/mL kanamycin and 50 \u03bcg/mL streptomycin. The A . tumefaciens cells were collected by centrifugation and diluted to an optical density at 660 nm (OD 660 ) of 0.15 in liquid induction medium (IM) (g/L: K 2 HPO 4 , 1.45, KH 2 PO 4 , 2.5, NaCl, 0.15, MgSO 4 , 0.5, CaCl 2 , 0.066, FeSO 4 , 0.0008, NH 4 SO 4 , 0.5, glucose, 1.8, 40 mM 2-[N-morpholino] ethanesulfonic acid, pH 5.3, 0.5% glycerol (w/v), 200 M acetosyringone), and induced for 6\u201312 h at 28 \u00b0C with shaking. After growing on potato dextrose agar (PDA) for 5 d at 28 \u00b0C, conidia of strain T23 were collected and diluted to 10 7 spores/mL using a sterilized physiological saline solution. For co-incubation, 100 \u03bcL of the T23 conidia suspension was mixed with an equal volume of A . tumefaciens cells, spread on the surface of a round cellophane paper, and placed horizontally on IM plates containing the ingredients of liquid IM medium except for 5 mM instead of 10 mM glucose and 15 g/L agar. The cells were co-cultivated at 25 \u00b0C in the dark. After 2 d, the cellophane paper was transferred to solid M-100 medium ( Stevens, 1974 ) supplemented with 300 \u03bcg/mL cefotaxime to inhibit growth of A . tumefaciens cells and 300 \u03bcg/mL hygromycin B as the selection agent for fungal transformants. Putative transformants formed within 3\u20137 d, the colonies were then transferred to M-100 plates that contained 300 \u03bcg/mL hygromycin B and plates were incubated at 25 \u00b0C. A . tumefaciens AGL-1 without the binary vector was used as a negative control. 2.3 Mitotic stability of transformants To determine the mitotic stability, the putative transformants were cultured five consecutive times on M-100 plates without hygromycin B, and then transferred to M-100 plates containing hygromycin B (300 \u03bcg/mL). 2.4 PCR and Southern analyses The strain T23 and its T-DNA transformants were inoculated into 100 mL PD medium prepared by boiling 200 g of peeled, cubed potatoes in 500 mL of water for about 40 min, adjusting the filtrate to 1 L with water and addition of 20 g of glucose. The culture was incubated in a rotary shaker at 180 rpm for 3 d at 28 \u00b0C. The mycelia were collected by filtration through lens paper, rinsed twice with sterile water, and dehydrated overnight in a freeze dryer. Fungal genomic DNA was extracted from lyophilized mycelia using a CTAB method ( Sambrook et al., 1998 ). PCR analysis to detect the hph gene in putative transformants was performed. The forward primer HPH1 was 5\u2032-CGACAGCGTCTCCGACCTGA-3\u2032, and the reverse primer HPH2 was 5\u2032-CGCCCAAGCTGCATCATCGAA-3\u2032. The PCR amplification protocol consisted of an initial denaturing cycle of 5 min at 95 \u00b0C, followed by 30 cycles of 94 \u00b0C for 30 s, 60 \u00b0C for 1 min and 72 \u00b0C for 2 min, with a final extension step at 72 \u00b0C for 8 min. Southern blot analysis was conducted as described by Tang et al. (2009) . The amplified PCR fragments (810 bp) of the hph gene were used as probes. Genomic DNA was digested with HindIII (37 \u00b0C, 12 h) or Bam HI (30 \u00b0C, 12 h). 40 \u03bcL of digested DNA were subjected to electrophoresis at 110 V for 5 min, and then at 80 V for 3 h in a 1.0% agarose gel. DNA was blotted onto Hybond N+ nylon membrane ( Sambrook et al., 1998 ). Purification and recovery of DNA probes were performed by using 3S spin DNA agarose gel purification kit (Shenergy Biocolor Co.). DNA labeling, hybridization and signal detection were conducted according to the manufacturer\u2019s instructions (AmershamGene Images CDP-Star Detection Kit, UK). 2.5 Screening of transformants for dichlorvos degrading ability A catalytic spectrophotometric method ( Zhou et al., 1996 ) was used to determine dichlorvos concentration in medium. The calibration curve of dichlorvos degradation was made according to the following procedure. The reaction was performed in 10 mL colorimeter tube. The mix contained 3.5 mL of dichlorvos solutions at various concentrations (dissolved in ethanol to reach the final concentrations of 20, 40, 60, 80, 100, 120, 140, 160, 180, and 200 \u03bcg/10 mL), 0.5 mL of Burk medium (g/L: KH 2 PO 4 , 0.8, K 2 HPO 4 , 0.2, CaSO 4 \u00b72H 2 O, 0.1, MgSO 4 \u00b77H 2 O, 0.2, (NH 4 ) 2 SO 4 , 1.0, MnSO 4 , 0.01, FeSO 4 \u00b77H 2 O, 0.005, Na 2 MoO 4 \u00b72H 2 O, 0.0033, glucose, 1.0, pH 6.0), 1 mL of 0.2% (w/v) Benzedrine Hydrochloride (dissolved in 40% ethanol), 1 mL of 10% (w/v) sodium citrate, 2 mL of 10% (v/v) H 2 O 2 and 2 mL of 0.1% (w/v) tartaric acid. After thorough mixing, the solution was incubated in a waterbath at 70 \u00b0C for 15 min, and then cooled rapidly to room temperature with flowing water for 10 min. The optical density at 410 nm (OD 410 ) of these solutions was determined. The concentration of residual dichlorvos was measured. 2.6 Determination of dichlorvos degradation Fungal transformants and parent strain T23 were incubated in flasks containing 200 ml PD at 28 \u00b0C at 200 rpm for 2 d. Mycelia were collected by filtration through lens paper, suspended in 400 mL sterile water and dried under vacuum. Two grams of mycelia were transferred to a flask containing 300 \u03bcg mL \u22121 dichlorvos in 100 ml of Burk medium and incubated at 28 \u00b0C at 200 rpm for 2 d. A 1.5-mL aliquot of culture was centrifuged at 12,000 rpm for 10 min, and 0.5 ml of supernatant was mixed with 3.5 ml 95% (v/v) ethanol to determine the optical density at 410 nm (OD 410 ). The measured concentration of residual dichlorvos was assigned as C 1 . The blank control, which has no mycelia, was also analyzed in the same conditions, and its dichlorvos concentration was designated as C 0 . The degradation rate (%) of dichlorvos was tested by calculated using the formula ( C 0 \u2212 C 1 )/ C 0 \u00d7 100%. 2.7 Assessment of tolerance to dichlorvos Transformants with altered dichlorvos degradation ability were cultured twice, and a 6-mm mycelia plug of each transformant was transferred to a M-100 plate (5-cm diameter) containing dichlorvos. Growth inhibition of each transformant was tested by inoculating M-100 media supplemented with mycelia plugs different concentrations of dichlorvos (100, 200, 300, 400, 500, 600, 700, 800 and 900 \u03bcg/mL). The mycelia were cultured at 28 \u00b0C for 4 d to confirm its highest tolerance to dichlorvos. 2.8 Morphological observation of transformants The transformants of T23 that exhibited improved or decreased dichlorvos degradation capability were subcultured twice on M-100 plates, and then 6-mm mycelial plugs of each transformant were transferred to M-100 plate (9-cm diameter). The growth diameter and morphology were recorded every 3 h. 2.9 Isolation of sequence flanking the inserted T-DNA in T. atroviride transformant To amplify the DNA flanking sequence of a T-DNA integration site in a T . atroviride transformant, a LA PCR\u2122 in vitro Cloning Kit (TaKaRa Co.; Code No.: DRR015) was used. The experimental procedure was conducted according to the Manual supplied with the cloning kit. Briefly, genomic DNA was digested with the restriction enzyme HindIII followed by the ligation of HindIII cassette. The ligation product was used as template for the first PCR with cassette primer C1 and primer S1 of the known T-DNA insertion sequence. A second PCR was performed by using primers designed for inner sequences, cassette primer C2 and primer S2 of the known T-DNA sequence. The primer S1 was 5\u2032-GCAAGGAATCGGTCAATACACTACATGGC-3\u2032 and the primer S2 was 5\u2032-GGTCTTGACCAACTCTATCAGAGCTTGGTTGAC-3\u2032 in this study. This procedure allowed for specific amplification of the left-flanking sequence of the T-DNA integration site. Finally, the specific PCR product was recovered from the gel after electrophoresis, and ligated to pMD18-T vector (TaKaRa Co.) to obtain the flanking sequence. 3 Results 3.1 Optimization of conditions for A. tumefaciens -mediated transformation (ATMT) of T. atroviride An optimal concentration of hygromycin B for selecting transformants of T . atroviride strain T23 was determined according to the previous report by Zhong et al. (2007) . Conidia spread on plates containing more than 240 \u03bcg/mL of hygromycin B did not germinate at all (data not shown). The growth of mycelia was inhibited at the hygromycin B concentration of 300 \u03bcg/mL. Thus, 300 \u03bcg/ml of hygromycin B was effective and suitable for screening of T23 transformants. To establish the suitable concentration of Agrobacterium strain AGL-1 for transformation efficiency, different concentrations of AGL-1 cells were applied. The results showed that when the AGL-1 cells reached OD 660 of 0.8 to 0.9, the transform efficiency was the highest ( Table 1 ). 3.2 Mitotic stability of T-DNA transformants 186 putative transformants obtained using vector pBHt1 were repeatedly transferred to nonselective medium in order to investigate the mitotic stability of the integrated T-DNA. Following five rounds of growth on nonselective medium, clones were transferred to selective medium. The result revealed that 300 \u03bcg/mL of hygromycin B was a reliable selection concentration when performing ATMT of T . atroviride strain T23. All transformants obtained under these conditions had high mitotic stability ( Table 2 ). 110 positive transformants were acquired in this study. 3.3 PCR analysis of T23 transformants To confirm the presence of the hph gene in the hygromycin B-resistant colonies, PCR amplication was performed using genomic DNA from 10 randomly selected putative transformants. Using the HPH1 and HPH2 oligonucleotide primers specific to the hph gene, it was possible to amplify a PCR product of the expected size (810 bp) from all the transformants tested, suggesting that the hph gene had been successfully integrated into genome of the T . atroviride strain 23. 3.4 Determination of the ability of transformants to degrade dichlorvos The dichlorvos degradation rates of 110 transformants ranged from 15.6% to 68.6% as compared to 56.7% of the parent strain T23. Fourteen transformants displayed improved dichlorvos degradation capacity. Two transformants (AMT-12 and AMT-28) exhibited an increase in dichlorvos degradation of more than 10% over that of the wild type ( p = 0.01 in least significant different test). Forty five transformants showed a decrease in dichlorvos degradation ability; among them, five transformants, AMT-18, AMT-25, AMT-44, AMT-64 and AMT-92 exhibited a decrease of more than 70% compared with the parent strain T23. 3.5 Morphological characters of transformants with obvious changes in dichlorvos degradation ability Growth rate and spore producing ability of seven transformants that had exhibited obvious changes in dichlorvos degradation ability were observed in nonselective PDA medium. The transformants AMT-12 and AMT-28, which expressed improved dichlorvos degradation ability, displayed lower spore production, but the same growth rate as wild strain T23 on nonselective PDA plate; However, the five transformants AMT-18, AMT-25, AMT-44, AMT-64 and AMT-92 showed a two-fold increase in growth rate and increased spore production compared to strain T23 under the same conditions ( Fig. 1 ). Transformants AMT-12 and AMT-28 grew as well as the wild type in the presence of 200 \u03bcg/mL of dichlorvos, and transformants AMT-18, AMT-25, AMT-44, AMT-64 and AMT-92 could tolerate up to 800 \u03bcg/mL of dichlorvos. 3.6 Molecular analysis of transformants To confirm that T-DNA was randomly integrated into the T . atroviride chromosomal DNA, and to determine the copy number of the transforming T-DNA, Southern blot analysis was conducted for the seven transformants exhibiting obvious changes in dichlorvos degrading ability. Genomic DNA digested with the restriction endonuclease BamHI or XbaI was hybridized with labeled 810 bp hph fragment. Both restriction enzymes cut the T-DNA of pBHt1 once outside the hph gene. Southern blotting showed that the T-DNA of vector pBHt1 was inserted at different sites of the genome of the transformants tested. AMT-12 and AMT-28 were confirmed to be transformants with single-copied T-DNA integration. AMT-25 and AMT-44 had triple integration sites of T-DNA in genomic DNA and AMT-18, AMT-64 and AMT-92 had two integration sites. The negative control, parent strain T23 showed no hybridization signal ( Fig. 2 ). 3.7 Cloning of flanking sequence of T-DNA insertion in transformant The region flanking the T-DNA integration in the transformant AMT-12 was successfully amplified using the LA PCR in vitro cloning strategy. An 1845-bp long left-flanking sequence was obtained (GenBank accession number: GQ223798) and compared with genome databases available at NCBI website (BLASTN 2.2.20+, NCBI). The cloned sequence has 89% identity with the genomic DNA of T . atroviride strain IMI 206040. Since transformant AMT-12 exhibited a statistically significant increase in dichlorvos degradation ability, it is possible that the T-DNA insertion occurred in DNA involved in degradation of this compound. 4 Discussion 4.1 Option of screening concentration of hygromycin B for transformants Since A . tumefaciens -mediated transformation of filamentous fungi was first reported ( de Groot et al., 1998 ), the technique has been successfully applied to over sixty species of filamentous fungi ( Michielse et al., 2005 ). Factors influencing the efficiency of ATMT, such as the components of induction medium, the concentration of acetosyringone (AS) and the hours of co-incubation, have been investigated ( Mullins et al., 2001; Covert et al., 2001; Combier et al., 2003; McClelland et al., 2005 ). In this study, the transformation condition of T . atroviride was optimized based on the previous studies. In earlier studies ( Cardoza et al., 2006; Migheli et al., 1996 ), the resistant phenotype was gradually lost over time because of the loss of the integrated fragment during the growth of the fungal cells under no selective pressure. In an effort to select for stable transformants, we adopted a concentration of 300 \u03bcg/mL hygromycin B. Some researchers have applied a concentration inhibiting spore germination ( Zhong et al., 2007 ), but we found that the effective inhibition concentration of mycelia growth was suitable for screening transformants in this study. An efficiency of transformation of about 50 transformants per 10 7 spores for T . atroviride was obtained, this result was lower than the reports in other fungi ( dos Reis et al., 2004; Weld et al., 2006 ), but comparable with the previous results in T . atroviride ( Cardoza et al., 2006; Zeilinger, 2004 ). In summary, the established transformation system is effective for T . atroviride . The integration of T-DNA usually results in obvious changes in colony morphology including the sporulation pattern and growth rate of the transformants. In our study, some transformants showed varied growth rate and spore production, these effects have also been described for T . atroviride strain P1 by Zeilinger (2004) . 4.2 The dichlorvos degradation capacities of transformants To degrade dichlorvos, previous studies have concentrated on photodegradation ( Lu et al., 1999; Benoit-Marqui\u00e9 et al., 2004; Oancea and Oncescu, 2008 ). Some attempts have recently been made to investigate the microbial degradation of dichlorvos ( Tang et al., 2009; Oncescu et al., 2007; Fu and Guo, 2006 ). Our experiment confirmed that T. atroviride strain T23 has obvious dichlorvos degradation potential regardless of whether there was a carbon resource (i.e. glucose) in the medium. In the present work, we used ATMT that differed from traditional isolation method ( Zhang et al., 2005; Li et al., 2008 ) to obtain transformants of T . atroviride with improved dichlorvos degradation ability, about 13% transformants showed a statistically significant increase in dichlorvos degradation capacity. Tang et al. (2009) reported that 76% restriction enzyme-mediated transformants had displayed increased dichlorvos degradation ability compared to that of the parent strain T . atroviride T23, but they had not isolated the potentially related sequences involved in the degradation of dichlorvos. We have developed a system to isolate the left-flanking sequence of T-DNA integration site in T . atroviride . Furthermore, an 1845-bp long flanking sequence was successfully isolated from the transformant AMT-12. The cloned sequence had never been reported in the previous literatures. It showed an 89% identity to the DNA from T . atroviride IMI 206040. As for the isolation of right flanking sequence of integration site of T . atroviride transformants, thermal asymmetric interlaced polymerase chain reaction (TAIL-PCR) ( Liu and Huang, 1998; Blaise et al., 2007; Zhong et al., 2007 ), panhandle PCR ( Jones, 1995 ) or inverse PCR ( Betts et al., 2007 ) are applicable. Further investigation is needed to confirm the biological function of the cloned sequence. It is not difficult to understand that if the exogenous T-DNA has been integrated into the coding region of a dichlorvos-degrading gene or a positive regulator gene, the dichlorvos degrading ability of the resulted transformants will be influenced. To our knowledge, there are no previous studies on microbial degradation of organophosphorus pesticide using Agrobacterium -mediated transformation of T . atroviride T23. The cloning of the functional fragment or gene that involved in dichlorvos degradation will facilitate the application of T . atroviride strain T23 in the environmental bioremediation. 5 Conclusion Our study results prove that A. tumefaciens -mediated transformation (ATMT) is an efficient way to obtained abundant transformants of T . atroviride strain T23 with diverse dichlorvos degrading capabilities. Moreover, we have described a system to isolate left-flanking sequence of targeted transformants efficiently in T . atroviride strain T23. The technique of ATMT offers an opportunity to study the molecular basis of dichlorvos degradation of T . atroviride . The fungus will be developed to a genetically modified organism and be applied in organophosphorus pollutant bioremediation in the future. Acknowledgements This work was funded by Shanghai Rising-star Program (07QA14035) and National High Technology Research and Development Program of China (2006AA10Z409, 2006AA10A211) and Foundation of Anhui Educational Committee (No. 2003kj282). We are most grateful to Dr. Seogchan Kang for critically reviewing the manuscript. Kehe Fu and Tong Liu are thanked for helpful discussions. References Benoit-Marqui\u00e9 et al., 2004 F. Benoit-Marqui\u00e9 C. de Montety V. Gilard R. Martino M.T. Maurette M. Malet-Martino Dichlorvos degradation studied by 31 P-NMR Environ. Chem. Lett. 2 2 2004 93 97 Betts et al., 2007 M.F. Betts S.L. Tucker N. Galadima Y. Meng G. Patel L. Li N. Donofrio A. Floyd S. Nolin D. Brown M. Alejandra Mandel T.K. Mitchell J.R. Xu R.A. Dean M.L. Farman M.J. Orbach Development of a high throughput transformation system for insertional mutagenesis in Magnaporthe oryzae Fungal Genet. Biol. 44 2007 1035 1049 Blaise et al., 2007 F. Blaise E. R\u00e9my M. Meyer L.G. Zhou J.P. Narcy J. Roux M.H. Balesdent T. Rouxel A critical assessment of Agrobacterium tumefaciens -mediated transformation as a tool for pathogenicity gene discovery in the phytopathogenic fungus Leptosphaeria maculans Fungal Genet. Biol. 44 2007 123 138 Cardoza et al., 2006 R.E. Cardoza J.A. Vizcaino M.R. Hermosa E. Monte S. Gutierrez A comparison of the phenotypic and genetic stability of recombinant Trichoderma spp. generated by protoplast- and Agrobacterium -mediated transformation J. Microbiol. 44 4 2006 383 395 Combier et al., 2003 J.P. Combier D. Melayah C. Raffier G. Gay R. Marmessie Agrobacterium tumefaciens -mediated transformation as a tool for insertional mutagenesis in the symbiotic ectomycorrhizal fungus Hebeloma cylindrosporum FEMS Microbiol. Lett. 220 2003 141 148 Covert et al., 2001 S.F. Covert P. Kapoor M.H. Lee A. Briley C.J. Nairn Agrobacterium tumefaciens -mediated transformation of Fusarium circinatum Mycol. Res. 105 3 2001 259 264 de Groot et al., 1998 M.J.A. de Groot P. Bundock P.J.J. Hooykaas A.G.M. Beijersbergen Agrobacterium tumefaciens -mediated transformation of filamentous fungi Nat. Biotechnol. 16 1998 839 842 dos Reis et al., 2004 M.C. dos Reis M.H.P. Fungaro R.T.D. Duarte L. Furlaneto M.C. Furlaneto Agrobacterium tumefaciens -mediated genetic transformation of the entomopathogenic fungus Beauveria bassiana J. Microbiol. Methods 58 2004 197 202 Fu and Guo, 2006 W.X. Fu L.Z. Guo Fungus for degrading dichlorvos: its isolation and characteristics Environ. Sci. Technol. 29 4 2006 32 35 Jones, 1995 D.H. Jones Panhandle PCR Genome Res. 4 1995 195 201 Li et al., 2008 X.H. Li J.D. Jiang L.F. Gu S.W. Ali J. He S.P. Li Diversity of chlorpyrifos-degrading bacteria isolated from chlorpyrifos-contaminated samples Int. Biodeter. Biodegr. 62 2008 331 335 Li et al., 2005 Y.Y. Li H.S. Hong X.H. Wang L.P. Zhang N.W. Chen The influence of rainfall on the runoff characteristics of organophosphorus pesticides (OPPs) in Wuchuan catchment, Fujian Province, China J. Xiamen Univ. (Nat. Sci.) 44 2005 84 88 Liu and Huang, 1998 Y.G. Liu N. Huang Efficient amplification of insert end sequences from bacterial artificial chromosome clones by thermal asymmetric interlaced PCR Plant Mol. Biol. Rep. 16 1998 175 181 Lu et al., 1999 M.C. Lu J.N. Chen C.P. Chang Oxidation of dichlorvos with hydrogen peroxide using ferrous ion as catalyst J. Hazard. Mater. B65 1999 277 288 McClelland et al., 2005 C.M. McClelland Y.C. Chang K.J. Kwon-Chung High frequency transformation of Cryptococcus neoformans and Cryptococcus gattii by Agrobacterium tumefaciens Fungal Genet. Biol. 42 2005 904 913 Meyer, 2008 V. Meyer Genetic engineering of filamentous fungi-progress, obstacles and future trends Biotechnol. Adv. 26 2 2008 177 185 Michielse et al., 2005 C.B. Michielse P.J.J. Hooykaas C.A.M.J.J. van den Hondel A.F.J. Ram Agrobacterium -mediated transformation as a tool for functional genomics in fungi Curr. Genet. 48 2005 1 17 Migheli et al., 1996 Q. Migheli O. Friard D. Del Tedesco M.R. Musso M.L. Gullino Stability of transformed antagonistic Fusarium oxysporum strains in vitro and in soil microcosms Mol. Ecol. 5 1996 641 649 Mullins et al., 2001 E.D. Mullins X. Chen P. Romaine R. Raina D.M. Geiser S. Kang Agrobacterium -mediated transformation of Fusarium oxysporum : an efficient tool for insertional mutagenesis and gene transfer Phytopathology 91 2 2001 173 180 Oancea and Oncescu, 2008 P. Oancea T. Oncescu The photocatalytic degradation of dichlorvos under solar irradiation J. Photochem. Photobiol. A: Chem. 199 2008 8 13 Oncescu et al., 2007 T. Oncescu P. Oancea M. Enache G. Popescu L. Dumitru M. Kamekura Halophilic bacteria are able to decontaminate dichlorvos, a pesticide, from saline environments Cent. Eur. J. Biol. 2 4 2007 563 573 Sambrook et al., 1998 J. Sambrook E.F. Fritsch T. Maniatis Molecular Cloning: A Laboratory Manual second ed. 1998 Cold Spring Harbor Laboratory Press Cold Spring Harbor, New York Singh and Walker, 2006 B.K. Singh A. Walker Microbial degradation of organophosphorus compounds FEMS Microbiol. Rev. 30 2006 428 471 Stevens, 1974 R.B. Stevens Mycology Guidebook 1974 University of Washington Press Seattle Tang et al., 2009 J. Tang L.X. Liu S.F. Hu Y.P. Chen J. Chen Improved degradation of organophosphate dichlorvos by Trichoderma atroviride transformants generated by restriction enzyme-mediated integration (REMI) Bioresour. Technol. 100 2009 480 483 Weld et al., 2006 R.J. Weld C.C. Eady H.J. Ridgway Agrobacterium -mediated transformation of Sclerotinia sclerotiorum J. Microbiol. Methods 65 2006 202 207 Zeilinger, 2004 S. Zeilinger Gene disruption in Trichoderma atroviride via Agrobacterium -mediated transformation Curr. Genet. 45 2004 54 60 Zhang et al., 2005 R.F. Zhang X.P. Wu B. Fan J. He J.D. Jiang S.P. Li Diversity of the organophosphate pesticide-degrading bacteria isolated from organophosphate polluted soil Acta Ecol. Sinica 25 6 2005 1502 1508 Zhang et al., 2006 X.H. Zhang G.S. Zhang Z.H. Zhang J.H. Xu S.P. Li Isolation and characterization of a dichlorvos-degrading strain DDV-1 of Ochrobactrum sp Pedosphere 16 1 2006 64 71 Zhang et al., 2002 Z.L. Zhang G. Yu H.S. Hong W.Q. Chen X.H. Wang Environmental behavior and risk assessment of organic phosphorus pesticides at water from Jiulong River estuary Environ. Sci. 23 2002 73 78 Bolton-Warberg et al., 2007 M. Bolton-Warberg L.D. Coen J.E. Weinstein Acute toxicity and acetylcholinesterase inhibition in grass shrimp ( Palaemonetes pugio ) and oysters ( Crassostrea virginica ) exposed to the organophosphate dichlorvos: laboratory and field studies Arch. Environ. Contam. Toxicol. 52 2 2007 207 216 Zhong et al., 2007 Y.H. Zhong X.L. Wang T.H. Wang Q. Jiang Agrobacterium -mediated transformation (AMT) of Trichoderma reesei as an efficient tool for random insertional mutagenesis Appl. Microbiol. Biotechnol. 73 2007 1348 1354 Zhou et al., 1996 Z.Y. Zhou T.S. Yin Y.H. Tang Catalytic spectrophotometric determination of trace dipterex Chin. J. Anal. Chem. 10 1996 1190 1192",
        "keywords": [],
        "authors": [
            {
                "name": "Wenliang Sun",
                "org": "College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua 321004, China"
            },
            {
                "name": "Lixing Liu",
                "org": "Department of Resources and Environmental Sciences, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China"
            },
            {
                "name": "Xiaolu Hu",
                "org": "Department of Resources and Environmental Sciences, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China"
            },
            {
                "name": "Jun Tang",
                "org": "School of Life Science, Fuyang Normal University, Fuyang 236041, China"
            },
            {
                "name": "Peng Liu",
                "org": "College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua 321004, China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Resources and Environmental Sciences, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China"
            },
            {
                "name": "Yunpeng Chen",
                "org": ""
            }
        ],
        "venue": "Bioresource Technology",
        "year": 2009
    },
    "0TLuEgpG": {
        "id": "0TLuEgpG",
        "title": "Progress on Studies of Head Smut Physiological Differential in Maize",
        "abstract": "Corn head smut Sporisorium relianum(kuhn.) langdon &Fullerton is one of major serious diseases threatening corn production.A detail review was made on the research progress of smut occurrence,pathogen biology and virulence differentiation,evaluation of cultivar resistance and breeding and IPM measures.",
        "keywords": [
            "Maize head smut",
            "Physiological differentiation",
            "Differential host"
        ],
        "authors": [
            {
                "name": "HE Zi-dian",
                "org": "Department of Agronomy,Hebei Sci-tech & Normal College,Hebei Changli ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Agriculture and Living Tthings,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "GAO Zeng-gui",
                "org": "Department of Agronomy,Hebei Sci-tech & Normal College,Hebei Changli ,China"
            },
            {
                "name": "ZHUANG Jing-hua",
                "org": "Department of Agronomy,Hebei Sci-tech & Normal College,Hebei Changli ,China"
            }
        ],
        "venue": "Journal of Maize Sciences",
        "year": 2005
    },
    "Xxh1aLqq": {
        "id": "Xxh1aLqq",
        "title": "A Two-Dimensional Electrophoresis Protocol Suitable for Proteomic Analysis of Cucumber Leaves",
        "abstract": "A 2-DE(tow-dimensional electrophoresis) protocol suited for the separation of proteins from cucumber leaves was established.Protein extraction,lysis buffer and IEF parameter were modified and improved to minimize markedly the interference by leaf pigments and other non-protein substances,thus resulting in satisfactory separation results.Cucumber leaves protein was extracted with DTT/ acetone or 20% w/v TCA in acetone,then resolubilized in lysis buffer(9.5mol\u00b7L-1 urea,2mol\u00b7L-1 thiourea,1% DTT,2mmol\u00b7L-1 TBP,4% CHAPS,0.2% Carrier ampholyte pH 3\uff5e10,0.25% Tween 20,10% Glycerol,10mmol\u00b7L-1 PMSF,10mM PSMF).Isoelectric focusing(IEF) was performed at 20\u2103 under the 25000Vh conditions.",
        "keywords": [
            "cucumber",
            "proteome",
            "two-dimensional electrophoresis"
        ],
        "authors": [
            {
                "name": "FAN Hai-yan",
                "org": "College of Bioscience and Technology,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "ZHANG Chun-yu",
                "org": "College of Bioscience and Technology,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "GUO Hai",
                "org": "Plant Materials Center for Soil and Water Conservation,Ministry of Water Resources,Beijing ,China"
            },
            {
                "name": "LIN Ying",
                "org": "College of Bioscience and Technology,Shenyang Agricultural University,Shenyang ,China"
            }
        ],
        "venue": "Journal of Shenyang Agricultural University",
        "year": 2008
    },
    "9msZ7yKl": {
        "id": "9msZ7yKl",
        "title": "Adenine deaminase is encoded by Tad1 and participates in copper accumulation in Trichoderma reesei.",
        "abstract": "We cloned a novel Tad1 gene and demonstrated that this gene is closely involved in copper bioaccumulation in Trichoderma reesei. Tad1 gene encodes a 510 amino acids protein of the amidohydrolase superfamily which belongs to COG0402. We found that adenine was the most efficient substrate of Tad1 protein among the substrates used in this study. Gene function was also investigated by overexpression and RNA interference. Results showed that copper accumulation increased in mutant cells when Tad1 was overexpressed; by contrast, copper accumulation significantly decreased when Tad1 was inhibited. To investigate the function of Tad1 in copper bioaccumulation, we determined adenine, hypoxanthine, and xanthine concentrations by reversed phase HPLC. Tad1 overexpression induced a substantial production of xanthine, which functions in binding numerous copper ions and reducing copper concentration. We further compared the gene expression profile of AT01 with that of a wild-type T. reesei strain grown in a medium containing 1.0mM Cu(2+) by performing DNA microarray. Several upregulated genes in the mutant were associated with adenine or copper metabolism.",
        "keywords": [
            "Adenine deaminase",
            "DNA microarray",
            "adenine deaminase",
            "Trichoderma reesei",
            "trichoderma reesei",
            "copper bioaccumulation",
            "dna microarray",
            "Copper bioaccumulation"
        ],
        "authors": [
            {
                "name": "Kehe Fu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Lili Fan",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Chuangjing Yu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Yingying Li",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Shigang Gao",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Yaqian Li",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Jie Chen",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            }
        ],
        "venue": "Fungal genetics and biology : FG & B",
        "year": 2014
    },
    "6E7I3Z1a": {
        "id": "6E7I3Z1a",
        "title": "Regular Disease Occurrence and Biocontrol Technology in Urban Rice-Duck Symbolic Breeding Farm",
        "abstract": "Effect of duck breeding on the occurrence of grass insects and spider disease in a compound field was studied by using a rice-duck symbiotic ecosystem.The results showed that the content of the dissolved oxygen in surface water layer was significantly improved when a relatively earlier stocking of duck with the density of 200 duck/hm2 was conducted(as the date July 10 and July 17).The concentration of surface soil organic carbon,nitrate ions,organic carbon and ammonium nitrogen were increased when the ducks were stocked at the date of July 17 and July 24.The control rate of farmland weeds in rice-duck field was 90%.The occurrence of rice planthoppers per 50 point of duck-rice field,matrine field and conventional insecticide-spraying field were below 200 head,below 300 head and below 350 head,respectively.The spider communities in rice-duck field were less than that in biocontrol field and chemical control field.The ducks raised in rice field can enhance the ability of lodging-resistance of rice.",
        "keywords": [
            "insect and weed",
            "occurrence regularity",
            "disease",
            "stoking time",
            "rice-duck simbiotic ecological system"
        ],
        "authors": [
            {
                "name": "SUN Xing-quan",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "LI Guang-Ji",
                "org": "Minhang District Shanghai Agricultural Technology Service Center,Shanghai ,China"
            },
            {
                "name": "YE Li-hong",
                "org": "Forest Bureau of Fengxian District,Shanghai ,China"
            },
            {
                "name": "TANG Ji-hong",
                "org": "Forest Bureau of Fengxian District,Shanghai ,China"
            },
            {
                "name": "YUAN Wei",
                "org": "Shanghai Yangtze River Modern Agriculture Co.,LTD,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Shanghai Jiaotong University(Agricultural Science)",
        "year": 2013
    },
    "yo41AnWF": {
        "id": "yo41AnWF",
        "title": "Research on Physiological Differentiation of Sporisorium reiliana",
        "abstract": "Sporisorium reiliana have been identified into 7 physiological differencial pathotype by 6 Differencial hosts:Isolates 03-13?03-04?03-07?03-22 and 03-12 are included into pathotype \u2160.Isolates 03-23?03-22?03-18?03-29 and 03-16 are included into pathotype \u2161.Pathotype \u2162 includes 03-20, 03-26, 03-16 and 03-14. Pathotype\u2163 includes 03-17?03-03?03-11 and 03-28. Pathotype\u2164 includes 03-02 and 03-08. Isolates 03-10 ?03-21 and 03-25 are included into pathotype\u2165. 03-01 is included into pathotype \u2166, Sorphium head smut pathogen is included into pathotype\u2160.",
        "keywords": [
            "Pathogen",
            "Maize head smut",
            "Physiological differentiation",
            "Differencial hosts"
        ],
        "authors": [
            {
                "name": "He Zidian",
                "org": "Hebei Normal University of Science&Techology, Qinhuangdao "
            },
            {
                "name": "Chen Jie",
                "org": "Agriculture and Biology College, Shanghai Jiaotong University, Shanghai "
            },
            {
                "name": "Gao Zenggui",
                "org": "Key Laboratory of Northern Crop Immunology China's Ministry of Agriculture, Shenyang Agricultural University, Shenyang "
            },
            {
                "name": "Zhuang Jinghua",
                "org": "Key Laboratory of Northern Crop Immunology China's Ministry of Agriculture, Shenyang Agricultural University, Shenyang "
            },
            {
                "name": "Qi Huixia",
                "org": "Hebei Normal University of Science&Techology, Qinhuangdao "
            },
            {
                "name": "Yang Wenlan",
                "org": "Hebei Normal University of Science&Techology, Qinhuangdao "
            }
        ],
        "venue": "Chinese Agricultural Science Bulletin",
        "year": 2006
    },
    "VGeQ9jkr": {
        "id": "VGeQ9jkr",
        "title": "Tmac1, a transcription factor which regulated high affinity copper transport in Trichoderma reesei.",
        "abstract": "The Mac1 protein was a transcriptional activator that sensed very low concentration of copper and regulated the copper transport in Saccharomyces cerevisiae. Here, we cloned a gene from Trichoderma reesei named Tmac1, whose deduced amino acid sequence showed 29% identical to Mac1p. Furthermore, two Cys-His repeats metal binding motifs of Tmac1p, one in the 354-369C terminus and one in the 475-490C terminus were also present in Mac1p. A deletion mutant of Tmac1 was hypersensitive to the copper starvation and showed poor growth. Subsequently, the function was recovered by the gene complementation experiment. Furthermore, the Tmac1 gene fully complemented growth defects of yeast \u0394Mac1 mutant. The expression of Tmac1p was activated at low concentration of copper and depressed when the concentration of copper excess 1mM. Furthermore, the fluorescence intensity enhanced at copper starvation and decreased under copper excess by fusion the eGFP to the Tmac1p. It proved that the expression of Mac1p was exactly regulated by copper concentration, because eGFP and Mac1p were expressed under the control of the same one promoter. We also cloned a gene named Tctr3 with bioinformatics. With a series of experiments, we proved it was the target gene of Tmac1. To sum up, Tmac1 may encode a transcriptional activator regulated high-affinity copper transport in T. reesei.",
        "keywords": [
            "copper transport",
            "high affinity",
            "tmac1",
            "trichoderma reesei"
        ],
        "authors": [
            {
                "name": "Kehe Fu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "LiLi Fan",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Yingying Li",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Shigang Gao",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Jie Chen",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            }
        ],
        "venue": "Microbiological research",
        "year": 2012
    },
    "8k3CDeI5": {
        "id": "8k3CDeI5",
        "title": "The pathway of 2,2-dichlorovinyl dimethyl phosphate (DDVP) degradation by Trichoderma atroviride strain T23 and characterization of a paraoxonase-like enzyme.",
        "abstract": "Dichlorvos (DDVP) is widely applied in the agricultural industry, and its residues are considered hazardous to the environment. Microbial bioremediation is an innovative technology with the potential to mitigate such pollution. Trichoderma atroviride strain T23, a filamentous fungus, is very efficient at degrading DDVP. Therefore, we used DDVP as a model organophosphate pesticide to study the mechanism by which Trichoderma degrades organophosphate pesticides, with the aim of attaining a global understanding of the molecular mechanism of enzymatic degradation of organophosphate pesticides by beneficial fungi. DDVP can be biodegraded via two routes, and the primary one involves hydrolysis of the P-O bond, which can result in the production of the novel degradation intermediate trichloroethanol. TaPon1-like showed continuously high expression during 120\u00a0h, and deletion of the gene decreased the efficiency of P-O bond hydrolysis. The enzyme produced by TaPon1-like had a low K for DDVP (0.23\u00a0mM) and a high k (204.3\u00a0s). The enzyme was able to hydrolyze broad substrates such as organophosphate oxons and lactone and maintain stable activity in a wide range of pH and temperature values. The TaPon1-like hydrolase played an important role in the first step of DDVP degradation by strain T23 and contributed to a comprehensive understanding of the mechanism of organophosphate pesticide degradation.",
        "keywords": [
            "Biodegradation",
            "Dichlorvos",
            "TaPon1-like",
            "Trichoderma atroviride strain T23"
        ],
        "authors": [
            {
                "name": "Jianan Sun",
                "org": "Key Laboratory of Urban (South) Agriculture, Ministry of Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China."
            },
            {
                "name": "Xu Yuan",
                "org": "Key Laboratory of Urban (South) Agriculture, Ministry of Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China."
            },
            {
                "name": "Yaqian Li",
                "org": "Key Laboratory of Urban (South) Agriculture, Ministry of Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China."
            },
            {
                "name": "Xinhua Wang",
                "org": "Key Laboratory of Urban (South) Agriculture, Ministry of Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China."
            },
            {
                "name": "Jie Chen",
                "org": "Key Laboratory of Urban (South) Agriculture, Ministry of Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China. jiechen59@sjtu.edu.cn."
            }
        ],
        "venue": "Applied microbiology and biotechnology",
        "year": 2019
    },
    "ReOeIckd": {
        "id": "ReOeIckd",
        "title": "Studies on the stability of Curvularia lunata toxin",
        "abstract": "The fungus Curvularia lunata could produce a large amount of toxin when it was cultured in Fries medium for 20 days.The toxin extract had pathogenic activity.The toxin could keep its activity under high temperature and for more than 30 days in refrigerator.The toxin had preferable stability even treated by light for 10 hours.",
        "keywords": [
            "toxin",
            "stability",
            "Curvularia lunata"
        ],
        "authors": [
            {
                "name": "Tang Shuge",
                "org": "Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "Mou Lin",
                "org": "Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "Zheng Qige",
                "org": "Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "Zhuang Jinghua",
                "org": "Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "Chen Jie",
                "org": "Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Plant Protection",
        "year": 2009
    },
    "Mvq2v2mm": {
        "id": "Mvq2v2mm",
        "title": "Effect of Soil pH on the Efficacy of Chemical Inducers against Verticillium Eggplant Wilt",
        "abstract": "Two chemical inducers,i.e.peracetic acid and trifluralin,were tested for their efficacy on Verticillium eggplant wilt.The results indicated that peracetic acid demonstrated better efficacy in soils of pH 5.8 and pH 6.6,and the soil pH was significantly and negatively correlated with disease control effect;while trifluralin showed greater efficacy in soils of pH 7.2 and pH 8.0,and also higher control effect.Soil pH demonstrated remarkable effect on induced resistance,and the results were quite different for different chemical inducers;best control effect could only be achieved in optimal soil pH.",
        "keywords": [
            "soil ph",
            "eggplant",
            "verticillium wilt",
            "chemical inducer",
            "disease resistance"
        ],
        "authors": [
            {
                "name": "TANG Bao-hong",
                "org": "Department of Bioenginering,Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "ZHANG Yi-zhe",
                "org": "Department of Bioenginering,Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai "
            }
        ],
        "venue": "Jiangsu Journal of Agricultural Sciences",
        "year": 2009
    },
    "qz8dC6s6": {
        "id": "qz8dC6s6",
        "title": "The Role of Ca2+ in Sugar Regulation of Defensive Reaction in Corn Against Pythium Inflatum",
        "abstract": "The content of sugar and activities of defensive enzymes in susceptible cultivars could be increased in the interaction of host - pathogen when host was treated with Ca2+, the same result was also supported by removing Ca2+ from resistant cultivars, in which contents of sugar and activities of defensive enzymes were parallel decline as decrease of Ca2+ content in the host plants. Furthermore, there was very significant correlation between soluble sugar content and defensive enzyme activity in different cultivars. Ca2+ and soluble sugar operated collectively the defensive reaction in corn against Pythium inflatum.",
        "keywords": [
            "Defensive enzymes",
            "Calcium",
            "Pythium inflatum",
            "Soluble sugar",
            "Maize"
        ],
        "authors": [
            {
                "name": "GAO Zeng-gui",
                "org": " College of Plant Protection, Shenyang Agricultural University, Shenyang "
            },
            {
                "name": "YU Chao-ge",
                "org": " College of Plant Protection, Shenyang Agricultural University, Shenyang "
            },
            {
                "name": "CHEN Jie",
                "org": " College of Agriculture and Biology, Shanghai Jiaotong University, Shanghai , China"
            },
            {
                "name": "ZHUANG Jing-hua",
                "org": " College of Plant Protection, Shenyang Agricultural University, Shenyang "
            }
        ],
        "venue": "Journal of Maize Sciences",
        "year": 2007
    },
    "xOvfQl8e": {
        "id": "xOvfQl8e",
        "title": "Cloning and function analysis of a drought-inducible gene associated with resistance to Curvularia leaf spot in maize.",
        "abstract": "ZmDIP was cloned and its function against Curvularia lunata was analyzed, according to a previous finding on a drought-inducible protein in resistant maize identified through MALDI-TOF-MS/MS. The ZmDIP expression varied in roots, leaf sheaths, and young, as well as old, leaves of different maize inbred lines. The ZmDIP transcript level changed in leaves over the course of time after inoculation with C. lunata. A prokaryotic expression analysis demonstrated that the gene can regulate the salt stress tolerance of Escherichia coli. The ZmDIP transient expression in the maize leaf showed that the gene was also linked to leaf resistance against the C. lunata infection. ZmDIP-mediated ROS and ABA signaling pathways were inferred to be closely associated with maize leaf resistance to the pathogen infection.",
        "keywords": [],
        "authors": [
            {
                "name": "Jiewei Zhu",
                "org": "Department of Plant Science, School of Agriculture and Biology, Key Laboratory of Urban Agriculture (South) of Ministry of Agriculture, Shanghai Jiao Tong University, Shanghai 200240, China."
            },
            {
                "name": "Xiuli Huang",
                "org": ""
            },
            {
                "name": "Tong Liu",
                "org": ""
            },
            {
                "name": "Shigang Gao",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Molecular biology reports",
        "year": 2012
    },
    "QGYEUIW2": {
        "id": "QGYEUIW2",
        "title": "Effects of environmental conditions and host growth stage on the infection by the pathogen of maize gray leaf spot",
        "abstract": "The gray leaf spot(GLS)on maize is a severe disease in China,which prevails only second to turcicum leaf blight and maydis leaf blight.This study focused on the effects of environmental conditions and maize growth stage on the infection of GLS(strain 20-47 on susceptible variety Yedan 13 and resistant variety Shendan 10) in phytotrons and under natural conditions.The results showed that GLS frequently occurred under high temperature and high humidity conditions.The pathogen couldn't infect the host when temperature and humidity were unsuitable.The optimum temperature for infection and disease development is about 25\u2103.The pathogen tended to infect plants with water drops on leaves. Both the concentration and spatial heterogeneity of soil nutrition,especially the content of nitrogen and phosphorus,affected the infection ability of this pathogen.High fertilization of nitrogen and phosphorus could improve the resistance of maize to GLS.Light intensity had no significant influence on the infection of GLS.But GLS tended to prevail under environmental light-dark alternation.The different growth stages of maize have different influences on pathogen infection.The pathogen tended to infect plants at the stage of 11-12 leaves.",
        "keywords": [
            "growth stage of maize",
            "infection",
            "environmental condition",
            "pathogen of gray leaf spot"
        ],
        "authors": [
            {
                "name": "Wang Guiqing",
                "org": "College of Agronomy,Liaocheng University,Liaocheng ,China"
            },
            {
                "name": "Chen Jie",
                "org": "College of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Plant Protection",
        "year": 2006
    },
    "kYzniiUX": {
        "id": "kYzniiUX",
        "title": "Evaluation of Biocontrol Trichoderma on Biology Security",
        "abstract": "\u3010Objective\u3011To detect bio-safety of Trichoderma,to evaluate the impact on partial ecological factor after the application of Trichoderma.\u3010Method\u3011Inoculate spores of Trichoderma into seeds,soil and water by means of conventional test methods,to detect its survival in water and its effects on rhizosphere microorganisms and growth of melon,as well as toxicity on mice and white rabbits.\u3010Result\u3011The majority of Trichoderma were safe to sweet-melon seeds and could increase significantly germination ratio,the number of fibrous roots and improve the growth of melon seedling.Trichoderma viride T23 did not show significant effects on the number of fungi,bacteria and actinomyces in rhizosphere soil of sweet-melon and water-melon.Spores of Trichoderma could not germinate in river,well water,rainwater and tap water.Conidiaspores and chlamydospores could survive in water for 12-20 days and 20-30 days,respectively.Trichoderma had no harm on the growth of fish.Meanwhile,it had low toxicity on rats in both stomach and skin toxicity experiments,and no allergic reaction to rabbit skin and mucous membrane of eyes.\u3010Conclusion\u3011Trichoderma is in-noxious and has no pollution,as same as other microbial pesticide.It is no risk using Trichoderma to control soil-spreading diseases.",
        "keywords": [
            "Rhizosphere microorganism",
            "Trichoderma",
            "Chlamydospores",
            "Biology security",
            "Conidiaspores"
        ],
        "authors": [
            {
                "name": "ZHUANG Jing-hua",
                "org": " College of Plant Protection,Shenyang Agricultural University,Shenyang "
            },
            {
                "name": "CHEN Jie",
                "org": " College of Plant Protection,Shenyang Agricultural University,Shenyang ; College of Agriculture and Biology,Shanghai Jiaotong University,Shanghai "
            },
            {
                "name": "YANG Chang-cheng",
                "org": " College of Plant Protection,Shenyang Agricultural University,Shenyang "
            },
            {
                "name": "GAO Zeng-gui",
                "org": " College of Plant Protection,Shenyang Agricultural University,Shenyang "
            },
            {
                "name": "LIU Xian",
                "org": " College of Plant Protection,Shenyang Agricultural University,Shenyang "
            },
            {
                "name": "MU Lian-xiao",
                "org": " College of Plant Protection,Shenyang Agricultural University,Shenyang "
            },
            {
                "name": "ZHENG Ya-nan",
                "org": " College of Plant Protection,Shenyang Agricultural University,Shenyang "
            }
        ],
        "venue": "Scientia Agricultura Sinica",
        "year": 2006
    },
    "OV74CzY4": {
        "id": "OV74CzY4",
        "title": "Study on the solid state fermentation condition for Trichoderma koningii REMI mutant to produce cellulase",
        "abstract": "The optimal condition of solid state fermentation for Trichoderma koningii REMI Mutant to produce cellulase was studied. The results based on orthogonal experiment showed that the components of the optimal solid culture medium followed the following ratio of matter : rice straw to bran (9:1);solid materials to water (1:1);1% (NH4)2SO4 , and 0.1% Tween-20. Moreover, the single- factor fermentation experiment on the mutant for improving cellulase activity indicated that the optimal culture condition should be : inoculum volume (5%\uff5e7.5%);temperature, 30 \u2103;incubation time, 96 h;pH value, neutral pH value. And under these conditions, the FPA and carboxyl methyl cellulase activity of T. koningii REMI mutant reached 6.097 IU/g and 8.123 IU/g respectively",
        "keywords": [
            "cellulose",
            "solid state fermentation",
            "Trichoderma koningii",
            "orthogonal experiment"
        ],
        "authors": [
            {
                "name": "HU Shi-feng",
                "org": " a.College of Bio-Safety Science and Technology"
            },
            {
                "name": "TANG Jun",
                "org": " School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "GAO Yong-dong",
                "org": " School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "ZHAI Zhi-wei",
                "org": " College of Plant Protect,SDAU,Tai\u2019an , Shandong ,China"
            },
            {
                "name": "LIU Li-xing",
                "org": " School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "GAO Bi-da",
                "org": " a.College of Bio-Safety Science and Technology"
            },
            {
                "name": "CHEN Jie",
                "org": " School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China; Key Laboratory of Microbial Metabolism,Ministry of Education,Shanghai ,China"
            }
        ],
        "venue": "Journal of Hunan Agricultural University(Natural Sciences)",
        "year": 2008
    },
    "0ShJVtae": {
        "id": "0ShJVtae",
        "title": "Effect of Active Oxygen in Tobacco Suspension Cultures Induced by Glucohexaose",
        "abstract": "Active oxygen could be induced to burst by glucohexaose in tobacco suspension cultures,and oxidative burst maximum was in 30 minutes,and relative enzyme activity of active oxygen was also improved in cells.The maximum of SOD activities was in 60 minutes,and the current of POD and CAT activities changes were similar to active oxygen.By adding different inhibitors such as EGTA,neomycin,LiCl and so on,intracellar and extracellar Ca2+ were indicated to be able to take part in regulating active oxygen burst induced by glucohexaose.",
        "keywords": [
            "active oxygen",
            "glucohexaose",
            "tobacco suspension culture",
            "peroxidases",
            "enzymes",
            "calcium ions",
            "tissue culture",
            "enzyme activity"
        ],
        "authors": [
            {
                "name": "SUN Yan-qiu",
                "org": "College of Plant Protection,Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "LI Bao-ju",
                "org": "Institute of Vegetables and Flowers,CAAS,Beijing ,China"
            },
            {
                "name": "SHI Yan-xia",
                "org": "Institute of Vegetables and Flowers,CAAS,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Jilin Agricultural University",
        "year": 2009
    },
    "YeIRprVt": {
        "id": "YeIRprVt",
        "title": "Production the Crude Extract of Curvularia lunata Toxin",
        "abstract": "It is showed that non-protein part in the original toxin liquid has the pathogenic activity.The activity part of the toxin extraction liquid is a kind of the polarity and small compound.It can be melted in methyl alcohol.Compared with other two bioassay methods(soaking and smearing),the fitted bioassay method is acupuncturing because it needs less toxin and can cause the evident sympton radiply.CHCl3-MeOH mixed solvent could extract the toxin.",
        "keywords": [
            "Production",
            "Toxin",
            "Curvularia lunata"
        ],
        "authors": [
            {
                "name": "TANG Shuge",
                "org": "Shenyang Agricultural Univercity,Shenyang ,China"
            },
            {
                "name": "ZHENG Qige",
                "org": "Shenyang Agricultural Univercity,Shenyang ,China"
            },
            {
                "name": "MU Lin",
                "org": "Shenyang Agricultural Univercity,Shenyang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Shanghai Jiaotong Univercity, Shanghai ,China"
            }
        ],
        "venue": "Acta Agriculturae Boreali-Occidentalis Sinica",
        "year": 2010
    },
    "VM9qw0gt": {
        "id": "VM9qw0gt",
        "title": "The Electrophoresis Analysis of Esterase Isozymes and Soluble Proteins of Transformed Trichoderma Strains",
        "abstract": "The soluble proteins and esterase isozyme of Trichoderma wild strain T21 and REMI transformed strains T31,T34,T47,T55 were analysed with polyacrylamide gel electrophoresis.The results showed that there were differences among transformed strains,between wide strain and transformed strains.The soluble proteins band amounts of wild strain T21 and REMI transformed strains T31,T34,T47,T55 were 22,21,19,17and24.The esterase isozyme band amounts was 6,8,14,15and3.",
        "keywords": [
            "esterase isozyme",
            "Trichoderma",
            "soluble proteins"
        ],
        "authors": [
            {
                "name": "HUANG Yu-qian",
                "org": "Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Shenyang Agricultural University,Shenyang ,China;Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "HAN Mei",
                "org": "Shenyang Agricultural University,Shenyang ,China"
            },
            {
                "name": "LIANG Chun-hao",
                "org": "Liaoning Academy of Agricultural Sciences,Shenyang ,China"
            }
        ],
        "venue": "Journal of Shenyang Agricultural University",
        "year": 2007
    },
    "2zw8HKKZ": {
        "id": "2zw8HKKZ",
        "title": "Efficacy of Resistance Induced by Trifluralin Against Verticillium Eggplant Wilt under Different Temperature Treatments",
        "abstract": "Trifluralin was evaluated for its efficacy as chemical inducer against Verticillium eggplant wilt under different field temperature. The results indicated that trifluralin could greatly reduced the severity of Verticillium eggplant wilt,with protection duration over 24 d. Temperature significantly affected the efficacy of trifluralin. Better control effect and longer duration was obtained at 20 \u2103 and 25 \u2103 than at 30 \u2103. Therefore,in the utilization of chemical inducers,management of optimal temperature was expected for better control effect and longer duration.",
        "keywords": [
            "verticillium wilt",
            "eggplant",
            "chemical inducer",
            "temperature",
            "induced resistance"
        ],
        "authors": [
            {
                "name": "Tang Baohong",
                "org": " Department of Bioengineering,Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "Yang Fan",
                "org": " College of Information and Business,Zhongyuan University of Technology,Zhengzhou ,China"
            },
            {
                "name": "Chen Jie",
                "org": " School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Henan Science",
        "year": 2009
    },
    "TpJIkNlT": {
        "id": "TpJIkNlT",
        "title": "Setup of differential host system for the identification of physiological differentiation in gray leaf spot pathogen of maize",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "WANG Gui-qing",
                "org": " School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": " School of Agriculture & Biology,Shanghai Jiaotong University,Shanghai ,China"
            }
        ],
        "venue": "Journal of\u3000Plant Protection",
        "year": 2005
    },
    "UupDO1Do": {
        "id": "UupDO1Do",
        "title": "Induced Resistance Response in Maize by Antagonistic Trichoderma Against Curvularia Leaf Spot",
        "abstract": "The role of bio-seed coating agents prepared respectively from Trichoderma strain H6,D9,C40,SH2303 in the induced resistance of maize against Currularia leaf spot was preliminarily evaluated in greenhouse and field.Results indicated that seeds-coated with strain H6,SH2303,C40 and D9 biomass were able to induce resistance response in seedling leaf to Curvularia lunata with control effect of 20.69%,37.52%,53.77%,72.74%,respectively.Meanwhile the activities of POD and PAL enzymes were significantly increased in seedling leaves developed from seeds coated with the Trichoderma strains above,whereas SOD enzyme activity in all treatments had no significant change.Therefore,maize leaf resistance induced by Trichoderma had positive correlation with the host PAL,POD activity,but no correlation with the activity of SOD.It is proved that seed-coating treatment with Trichoderma could develop a systemic resistance response against leaf spot pathogen in seedling stage.",
        "keywords": [
            "defense enzymes",
            "Curvularia lunata",
            "Trichoderma spp",
            "induced resistance"
        ],
        "authors": [
            {
                "name": "ZHANG Ting",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "ZHU Jie-wei",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China"
            },
            {
                "name": "WU Xiang-wen",
                "org": "Shanghai Agricultural Technology Extension Service Center,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai ,China;The National Maize Industry Technology RD Center,Beijing ,China"
            }
        ],
        "venue": "Journal of Shanghai Jiaotong University(Agricultural Science)",
        "year": 2011
    },
    "MVRqAsYZ": {
        "id": "MVRqAsYZ",
        "title": "Effects of Ligustrazin on High-glucose-induced Transdifferentiation of Human Renal Proximal Tubular Epithelial Cells",
        "abstract": "Objective To investigate the effects of ligustrazin on high-glucose-induced HK-2 transdifferentiation in human renal proximal tubular epithelial cells.Methods HK-2 cells were cultured in vitro with high glucose(25 mmol/L of D-glucose),recombinant high glucose and ligustrazin for 48 h.Ligustrazin was added 30min prior to high glucose and subsequently co-treated for 48 h in concentrations of 40,80,160 \u03bcg/ml,respectively.Morphological changes were assessed by phase contrast microscopy,transdiferentiation of tubular cells into myofibroblasts by immunofluorescence with monoclonal antibodies to \u03b1-SMA,and the expression of \u03b1-SMA and E-cadherin mRNA by RT-PCR.Results High glucose induced striking morphological changes in epithelial cells.With the co-intervention of 80 \u03bcg/ml ligustrazine,no significant changes were noted in cell morphology.Immunofluorescence showed that \u03b1-SMA expression enhanced significantly after stimulation by high glucose,but reduced after addition of 80 \u03bcg/ml ligustrazine.By RT-PCR,high glucose up-regulated \u03b1-SMA mRNA significantly,but decreased E-cadherin mRNA(P<0.01).Recombinant high glucose with ligustrazine up-regulated E-cadherin mRNA(P<0.01)but reduced \u03b1-SMA mRNA in a dose-dependent manner.Conclusion Ligustrazin can attenuate high glucose-induced EMT,thereby to prevent tubulointerstitial fibrosis in diabetic nephropathy.",
        "keywords": [
            "Tetramethylpyrazine",
            "Kedney tubules",
            "Hyperglycemia",
            "Cell differentiation"
        ],
        "authors": [
            {
                "name": "WU Xiao-nan",
                "org": ",et al.School of Public Health,Fujian Medical University,Fuzhou ,China"
            },
            {
                "name": "WU Yi-lan",
                "org": ",et al.School of Public Health,Fujian Medical University,Fuzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": ",et al.School of Public Health,Fujian Medical University,Fuzhou ,China"
            }
        ],
        "venue": "Chinese General Practice",
        "year": 2009
    },
    "WZRee7Rt": {
        "id": "WZRee7Rt",
        "title": "The Necessity of Construction of Audiovisual Teaching Material for General Practice Education and the Theme Selection",
        "abstract": "This paper discussed the necessity of construction of audiovisual teaching material for general practice education and important notes in the theme selection according to the situation of general practice,the teaching plan and teaching content.",
        "keywords": [
            "Theme selection",
            "General practice education",
            "Audiovisual teaching material"
        ],
        "authors": [
            {
                "name": "YAO Zhong-ling",
                "org": ".Teaching Management Department of Fujian Medical University,Fuzhou,China"
            },
            {
                "name": "CHEN Jie",
                "org": ".Teaching Management Department of Fujian Medical University,Fuzhou,China"
            },
            {
                "name": "WU Xiao-nan",
                "org": ".Teaching Management Department of Fujian Medical University,Fuzhou,China"
            }
        ],
        "venue": "Chinese General Practice",
        "year": 2007
    },
    "fDgcVmTr": {
        "id": "fDgcVmTr",
        "title": "Protective effect of lotus-seed milk fermented product on acute CCl_4 hepatic toxicity in mice",
        "abstract": "Objective To explore the protective effect and possible mechanism of Lotus-seed Milk Fermented Product(LMFP) from acute CCl_4 hepatic toxicity in mice.Methods Ascertain the effect of lotus-seed milk fermented product on LPO of normal liver homogenate and normal hepatic homogenate excitated by cysteine and ferrous sulfate in vitro.Mice were fed with distilled water,25%,50%,100% LMFP and VE,intraperitoneal injected Carbon Tetrachloride(CCl_4) vegetal oil admixture in the 14th day.The examines assessing the degree of the hepatic acute damage and peroxidization were executed.Pathomorphological changes were detected by Haematoxylin eosin(HE) coloration and immunohistochemistry.Results Lactiperoxidase(LPO)level of normal liver homogenate and hepatic homogenate excitated by cysteine and FeSO_4 in LMFP groups were significantly decreased compared with the control group.Compared with the model group,Hepatocyte swell,necrosis and inflammatory cells penetration in the LMFP and VE groups were relieved,Bcl-2 express enhanced.Latic dehydrogenase(LDH) activity was decreased,LPO level was observably decreased,Superoxide dismutase(SOD) activity was significantly increased in LMFP groups.(all Significance,P<0.05).Conclusion LMFP can protect liver from acute CCl_4 hepatic toxicity by the mechanism of anti-oxide system.",
        "keywords": [
            "dietary supplement",
            "Lotus-seed milk fermented product(LMFP)",
            "peroxidation",
            "carbon tetrachloride"
        ],
        "authors": [
            {
                "name": "WU Xiaonan",
                "org": "Fuzhou ,China"
            },
            {
                "name": "LIN Jianyin",
                "org": "Fuzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Fuzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Public Health",
        "year": 2006
    },
    "Kn9qG5ed": {
        "id": "Kn9qG5ed",
        "title": "The Effect of Garlic on Learoing and Memory Ability in Alcohol-Induced Neurotoxicity Mouse",
        "abstract": "Objective To demonstrate whether garlic could extenuate alcohol-induced neurotoxicity in mouse.Methods 60 ICR mice were randomly divided into six groups,each of ten.The mice in alcohol+high-dose Garlic,alcohol+middle-dose Garlic,alcohol+low-dose Garlic and alcohol+Vitamin E(VE) were pretreated intragastrically with 250,500,750 mg/kg garlic and 500 mg/kg VE,while others were given distilled water as control.Animals were administered 50% alcohol(15 mL/kg) orally once a day;control animals were given distilled water only.After 28 days,the mice were taken the test of Morris Water Maze respectively before and after the intervention.At the same time,we measured the total scores and the moving track of the mouse in each group in the four quadrants once daily for 5 days.Results There are no differences on the total scores of the four quadrants among the groups before the intervention(P>0.05).28 days later,a significant increase on scores of all quadrants were recorded in mice treated with alcohol alone(P<0.05).Compared to the alcohol group,both the high and middle-dose could decrease the total scores of most quadrants(P<0.05).But VE and low-dose garlic only degraded total scores in few quadrants.Conclusion The changes of learning and memory and mental disorder are events after subchronic alcohol exposure.Being pretreated with garlic extract exerted the neuroprotective effect,and was more efficient than VE.",
        "keywords": [
            "learning and memory ability",
            "alcohol",
            "protective effect",
            "Garlic",
            "hepatotoxicity"
        ],
        "authors": [
            {
                "name": "Zhu Pingping",
                "org": " Division of Nutrition and Health Care,Fujian Medical University,Fuzhou ,China"
            },
            {
                "name": "Wu Xiaonan",
                "org": " Division of Nutrition and Health Care,Fujian Medical University,Fuzhou ,China"
            },
            {
                "name": "Chen Jie",
                "org": " Division of Nutrition and Health Care,Fujian Medical University,Fuzhou ,China"
            }
        ],
        "venue": "Journal of Fujian Medical University",
        "year": 2007
    },
    "jhBUhTAW": {
        "id": "jhBUhTAW",
        "title": "Protection effect of lotus-seed milk fermented production on intestinal mucosal barrier of mice",
        "abstract": "Objective To explore the effect and mechanism of lotus-seed milk fermented production(LMFP) on the intestinal mucosal barrier of mice.Methods 60 male ICR mice were randomly assigned into five groups.The mice were pretreated intragastrically with distilled water,lotus-seed milk fermented production,lotus-seed milk and fermented milk once daily for two weeks.Twenty-four hours after the last dosing,animals were administered with LPS[6 mg/(kg\u00b7bw)] intraperitoneally,control animals were given distilled water only.Eighteen hours after the intoxication,the indices were measured.Results The mice injected with LPS showed the symptoms of sluggish in varying extent,especially in model group.The LMFP group was the most slight compared with other groups.The lotus-seed milk fermented production can significantly improve the concentration of intestinal SIgA and the quantity of white blood cell(P<0.001,P=0.001),retain the amount of lactobacillus acidophilus(P<0.001),decrease the concentration of TNF-\u03b1 in serum induced by LPS and the quantity of Escherichia coli in the mouse's caecum.The protective effect of lotus-seed milk fermented production on the intestinal mucosal barrier harmed by LPS was significantly better than fermented milk,and there was no protection in lotus-seed milk group.Conclusion The model of intestinal mucosal barrier harmed by LPS was established successfully.The lotus-seed milk fermented production can protect the intestinal mucosal barrier against harm caused by LPS,and relieve the response of systemic inflammatory.",
        "keywords": [
            "lotus-seed milk fermented production",
            "intestinal mucosal barrier",
            "prebiotics",
            "probiotics",
            "lipopolysaccharide(LPS)"
        ],
        "authors": [
            {
                "name": "WU Xiao-nan",
                "org": "Fuzhou ,China"
            },
            {
                "name": "CHEN Zhong-long",
                "org": "Fuzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Fuzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Public Health",
        "year": 2008
    },
    "8I3i32wU": {
        "id": "8I3i32wU",
        "title": "Effect of HGPRT Locus Mutation of Fish Sauce on Chinese Hamster Ovary Cells",
        "abstract": "BACKGROUND AND AIM: To explore fish sauce and nitrosated fish sauce on HGPRT mutation of Chinese hamster ovary cells. MATERIALS AND METHODS: Using the HGPRT gene mutation assay with soft agar method, we set up four dosage groups of fish sauce and nitrosated fish sauce: 5 \u03bcl/ml,2.5 \u03bcl/ml,1.25 \u03bcl/ml,0.625 \u03bcl/ml, and the positive control groups of EMS: 0.75 \u03bcg/ml, MCA: 4 \u03bcg/ml and the negative control group (distilled water).Then we calculated mutant frequency of all treatment groups to assess the mutagenesis of fish sauce and nitrosated fish sauce on CHO cells. RESULTS: The mutant frequency of all treatment groups were significantly different(\u03c72S9-=41.115;FS9+=19.528;P<0.01). The frequency in nitrosated fish sauce groups and fish sauce groups by S9 metabolic activation was significantly higher than those in control groups (P<0.05 or P<0.01), with a dose-response relationship(S9-: r nitrosated fish sauce=0.986, P<0.05; S9+: r fish sauce=0.950, P=0.05, r nitrosated fish sauce=0.997, P<0.01); But the difference of mutant frequency between fish sauce without S9 and control group was not significant(P>0.05). CONCLUSION: Fish sauce nitrosation of mobile vendors in the area could cause HGPRT locus mutation of CHO cells, and S9 metabolic of fish sauce might also cause this effect.",
        "keywords": [
            "fish sauce",
            "HGPRT locus mutation",
            "Chinese hamster ovary cells"
        ],
        "authors": [
            {
                "name": "WANG Chun-lan",
                "org": "Nutrition Department of Public Health School of Fujian Medical University, Fuzhou , Fujian, China"
            },
            {
                "name": "WU Xiao-nan",
                "org": "Nutrition Department of Public Health School of Fujian Medical University, Fuzhou , Fujian, China"
            },
            {
                "name": "CHEN Jie",
                "org": "Nutrition Department of Public Health School of Fujian Medical University, Fuzhou , Fujian, China"
            },
            {
                "name": "WU Yi-lan",
                "org": "Nutrition Department of Public Health School of Fujian Medical University, Fuzhou , Fujian, China"
            }
        ],
        "venue": "Carcinogenesis,Teratogenesis & Mutagenesis",
        "year": 2008
    },
    "8hVYXHzJ": {
        "id": "8hVYXHzJ",
        "title": "Study on regulation of immunity function of macrophage cell line RAW264.7 by crude polysaccharide extracted from enteromorpha",
        "abstract": "Objective To study regulation of immunity function of macrophage cell line RAW264.7 by crude polysaccharide extracted from enteromorpha.Methods RAW264.7 cells were cultured in vitro and the proliferation levels were detected by MTT colorimetric assay,the changes of cytokine secretion were detected by ELISA method.Results In a certain concentration range and intervention time,crude polysaccharide extracted from enteromorpha promoted RAW264.7 proliferation,cytokines expression levels of TNF-\u0251 and IL-6 secretion were significantly increased with the doses.Conclusion There exist immuno-modulation function for crude polysaccharide extracted from enteromorpha to macrophage cell line RAW264.7.",
        "keywords": [
            "TNF-\u03b1",
            "RAW264.7",
            "Polysaccharide from Enteromorpha",
            "IL-6",
            "Immunity"
        ],
        "authors": [
            {
                "name": "CHEN rong-fang",
                "org": " Fujian Medical University,Fujian  China"
            },
            {
                "name": "WU xiao-nan",
                "org": " Fujian Medical University,Fujian  China"
            },
            {
                "name": "CHEN jie",
                "org": " Fujian Medical University,Fujian  China"
            }
        ],
        "venue": "Strait Journal of Preventive Medicine",
        "year": 2012
    },
    "1dwAdZxi": {
        "id": "1dwAdZxi",
        "title": "Screening for effective polyphenols on multidrug resistance to human breast carcinoma MCF-7/ADM cells",
        "abstract": "Objective To screen effective polyphenols on multidrug resistance to human breast carcinoma MCF-7/ADM cells.Methods The cytotoxicity of catechin,quercetin,resveratrol,daiazein,sesamin and ferulic acid to human breast carcinomal MCF-7/ADM cells were determined with MTT and uniform design assay;and toxic effect on the liver cell DNA was observed with improved single cell gel electrophoresis assay.Results Quercetin,resveratrol and ferulic acid significantly inhibited the proliferation of MCF-7/ADM cells.Resveratrol markedly enhanced the sensitivity of MCF-7/ADM cells to ardriamycin with no toxic to normal cells.Conclusions Resveratrol can inhibit proliferation of MCF-7/ADM cells in vitro with no toxicity to normal cells.",
        "keywords": [
            "phenols/pharmacology",
            "doxorubicin/pharmacology",
            "breast neoplasms/drug therapy",
            "breast neoplasms/pathology",
            "tumor cells",
            "cultured",
            "antineoplastic combined chemotherapy protocols/therapeutic use",
            "cell cultures",
            "polyphenols",
            "cytotoxicity"
        ],
        "authors": [
            {
                "name": "HUANG Fang",
                "org": "Department of Nutrition and Health Care,Fujian Medical University,Fuzhou,,China"
            },
            {
                "name": "HUANG Zi-jie",
                "org": "Department of Nutrition and Health Care,Fujian Medical University,Fuzhou,,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Department of Nutrition and Health Care,Fujian Medical University,Fuzhou,,China"
            }
        ],
        "venue": "Journal of Practical Oncology",
        "year": 2009
    },
    "hL1EDKQs": {
        "id": "hL1EDKQs",
        "title": "Effects of DNA damage of fish sauce on gastric epithelial cell",
        "abstract": "Objective To explore damage effect of fish sauce and nitrosated fish sauce on DNA in gastric epithelial cell.Methods The DNA damage effect of fish sauce on gastric epithelial cell was observed in vitro and in vivo by improved single cell gel electrophoresis assay.Results The tail length,tail moment and OLIVE tailmomentin for nitrosated fish sauce groups of high dose((13.42\u00b13.74),(1.12\u00b10.67),(1.21\u00b10.71)\u03bcm),middle dose((12.68\u00b14.44),(1.07\u00b10.68),(1.12\u00b10.69)\u03bcm) and low dose((11.79\u00b14.49),(0.98\u00b10.72),(1.05\u00b10.70)\u03bcm) were significantly higher than those in control group((9.14\u00b12.54),(0.62\u00b10.60),(0.60\u00b10.59)\u03bcm) in vitro.There were statistical differences between any two groups(\u03c72taillength=296.10;Ftailmoment=27.62;(\u03c72OLIVE tailmoment=436.62;P<0.01).And in vivo the taillength,tailmoment and OLIVE tailmoment in the groups of 50% nitrosated fish sauce((14.51\u00b14.54)(2.76\u00b12.26)(3.03\u00b12.32)\u03bcm) and 25% nitrosated fish sauce((13.49\u00b14.42)(2.06\u00b11.86)(2.25\u00b11.98)\u03bcm) were higher than those in control group((11.82\u00b13.80)(1.12\u00b10.80)(1.35\u00b11.19)\u03bcm).There were also statistical differences between any two groups(\u03c7taillength=88.11;\u03c7tailmoment=165.83;\u03c7tailmoment=198.11;P<0.01).And in vitro the higher the concentration of nitrosated fish sauce was,the stronger the damage effect of DNA was.There was dose-response relationship(rtaillength=0.999,P<0.05,rOLIVE tailmoment=0.997,P<0.05).Conclusion Fish sauce exists damage effect on DNA in gastric epithelial cell through nitrosation.",
        "keywords": [
            "DNA damage",
            "fish sauce",
            "gastric epithelial cell",
            "single cell gel electrophoresis"
        ],
        "authors": [
            {
                "name": "WU Xiao-nan",
                "org": "Fuzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Fuzhou ,China"
            },
            {
                "name": "WANG Chun-lan",
                "org": "Fuzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Public Health",
        "year": 2008
    },
    "71Hwg4NX": {
        "id": "71Hwg4NX",
        "title": "Reversal Effects of Resveratrol on Multidrug-resistance of Human Breast Cancer Cell Line MCF-7/ADM",
        "abstract": "Objective To study the reversal effect of resveratrol on multidrug-resistance of human breast cancer cell line MCF-7/ADM,and the related mechanism. Methods MTT assay was used to detect the inhibitory effect of resveratrol of different concentrations on the proliferation of human breast cancer cell line MCF-7/ADM,and the Jin's formula to assess the combined effect of Res and ADM on cancer line MCF-7/ADM.In addition,the concentrations of ADM in MCF-7/ADM cells were detected by Fluorescence Spectrophotometry while Resveratrol of different concentrations was given. Results Resveratrol combined with ADM possessed synergistic effect,and the reversal index was 1.950 in ADM+ 4 \u03bcmol/L Res,2.178 in ADM+ 8 \u03bcmol/L Res,and 2.355 in ADM+ 12 \u03bcmol/L Res.Resveratrol was observed to greatly elevate the concentration of ADM in MCF-7/ADM cells at a dose-related manner(compared to the control group,P<0.05).Conclusions Resveratrol has a sensitizing effect on multidrug-resistance of human breast cancer cell line MCF-7/ADM in that it could partially reverse MDR in MCF-7/ADM cells.The reversal is coorelated with elevated concentration of ADM in MCF-7/ADM cells.",
        "keywords": [
            "neoplasm",
            "drug resistance",
            "tumor cells",
            "epirubicin",
            "cultured",
            "multiple",
            "veratrum alkaloids",
            "breast neoplasms"
        ],
        "authors": [
            {
                "name": "HUANG Fang",
                "org": "Department of Nutrition and Health Care,School of Public Health,Fujian Medical University,Fuzhou ,China"
            },
            {
                "name": "WU Xiaonan",
                "org": "Department of Nutrition and Health Care,School of Public Health,Fujian Medical University,Fuzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Department of Nutrition and Health Care,School of Public Health,Fujian Medical University,Fuzhou ,China"
            },
            {
                "name": "WANG Jiali",
                "org": "Department of Nutrition and Health Care,School of Public Health,Fujian Medical University,Fuzhou ,China"
            }
        ],
        "venue": "Journal of Fujian Medical University",
        "year": 2009
    },
    "KCjqj85p": {
        "id": "KCjqj85p",
        "title": "On Experiment Reforms in the Course of Nutrition and Food Hygienic",
        "abstract": "The article summarizes the comprehensive experiment reforms in the course of Nutrition and Food Hygienic,and expounds on several concrete practices for curriculum design,construction of teaching materials,improving teachers' quality,and offering of innovative experiment items.",
        "keywords": [
            "comprehensive experiment",
            "nutrition",
            "reform",
            "food hygienic",
            "experimental teaching"
        ],
        "authors": [
            {
                "name": "HUANG Fang",
                "org": "School of Public Health,Fujian Medical University,Fuzhou ,China"
            },
            {
                "name": "WU Xiao-nan",
                "org": "School of Public Health,Fujian Medical University,Fuzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Public Health,Fujian Medical University,Fuzhou ,China"
            },
            {
                "name": "ZHENG Ling",
                "org": "School of Public Health,Fujian Medical University,Fuzhou ,China"
            }
        ],
        "venue": "Journal of Fujian Medical University(Social Science Edition)",
        "year": 2007
    },
    "aAtWrXDz": {
        "id": "aAtWrXDz",
        "title": "Studies on Anti-tumor Activities of Enteromorpha Chlorella Growth Factor in Experimental Liver Cancer and its Mechanism",
        "abstract": "Objective To provide the basis for developing and utilizing the resources of Enteromorpha,the anti-tumor effects of ECGF and its related mechanism were investigated.Methods H22 cancer-bearing mice models were established,into which ECGF of different dosages were gavaged.Anti-tumor activities were then observed by testing tumor inhibitory rate,the index of spleen and the contents of IL-2,TGF-\u03b2 and VEGF.Results The growth of H22 sarcoma was significantly inhibited in the low,middle,and high dosage of ECGF groups.The tumor inhibitory rates were 13.9%,30.3% and 27.3% respectively.High-dose ECGF significantly increased the level of IL-2(P<0.01).All ECGF intervention groups could greatly increase the spleen index(P<0.01)and decrease the TGF-\u03b2 and VEGF level(P<0.01).Conclusions ECGF has an inhibitory effect on the experimental H22 cancer-bearing mice models,and its mechanism is probably associated with the level of IL-2,TGF-\u03b2 and VEGF.",
        "keywords": [
            "interleukin-2",
            "transforming growth factor beta",
            "liver neoplasms",
            "green",
            "vascular endothelial growth factors",
            "experimental",
            "algae"
        ],
        "authors": [
            {
                "name": "LIN Wenting",
                "org": " Department of Nutrition and Health Care,College of Public Health,Fujian Medical University,Fuzhou ,China"
            },
            {
                "name": "WU Xiaonan",
                "org": " Department of Nutrition and Health Care,College of Public Health,Fujian Medical University,Fuzhou ,China"
            },
            {
                "name": "ZHU Pingping",
                "org": " Department of Nutrition and Health Care,College of Public Health,Fujian Medical University,Fuzhou ,China"
            },
            {
                "name": "ZHANG Zhifang",
                "org": " Department of Nutrition and Health Care,College of Public Health,Fujian Medical University,Fuzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": " Department of Nutrition and Health Care,College of Public Health,Fujian Medical University,Fuzhou ,China"
            }
        ],
        "venue": "Journal of Fujian Medical University",
        "year": 2009
    },
    "7YUwif4e": {
        "id": "7YUwif4e",
        "title": "Effect leinoleic acid/docosahexaenoic acid on apoptosis of human gastric cancer cells",
        "abstract": "Objective To explore the effects of different constituent ratio leinoleic acid(LA)/docosahexaenoic acid(DHA) on apoptosis of human gastric cancer cell line MKN-45.Methods With uniform design,the better constituent ratio for the inhibition of MKN-45 cell was scrceend.Then the best ratio was determined with randomized block design.The tumor volume,side-effect,and tumor weigh of tumor-bearing nude mice after treatment were observed.The morphological changes of tumor tissue were assessed by HE staining.Results The LA/DHA constituent ratio of 1:3 showed maximum inhibition of the tumor cells.Six weeks after high concentration treatment,the mean tumor volume decreased by 21.97% and the mean tumor weigh by 18.09% with statistical significance compared with that of control group(P<0.05).The toxicity of the treatment was not obvious.Microscopic examination showed that there were massive areas of cytoclasis and apoptosis in the tumor tissue of the high concentration group and 5-FU group.Conclusion The 1:3 constituent ratio of LA/DHA could induce the apoptosis of human gastric cancer cell line MKN-45.The high concentration of 1:3 constituent ratio treatment could also inhibit tumor in vivo without significant side-effect.",
        "keywords": [
            "docosahexaenoic acid(DHA)",
            "apoptosis",
            "leinoleic acid(LA)",
            "nude mouse",
            "human gastric cell line MKN-45"
        ],
        "authors": [
            {
                "name": "HUANG Fang",
                "org": "Fuzhou ,China"
            },
            {
                "name": "WU Xiao-nan",
                "org": "Fuzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Fuzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Public Health",
        "year": 2010
    },
    "VTiuiTps": {
        "id": "VTiuiTps",
        "title": "Design of the Bearing Variable Load Pressure Experimental System",
        "abstract": "To overcome the defects of the existing bearing test bed that the loading force cannot not be adjusted in accordance with arbitrary load spectrum,the control scheme combining PLC and virtual instrument is proposed.Simple and reliable control is conducted by PLC in lower level,and by adopting virtual instrument in upper level for complex loading control.The control scheme and coordinated implementation of PLC transmission protocol are described in detail.Under permissive load range,this scheme is conducting setting load spectrum experiment through adjustable input of the test bad,this makes the test time effectively decreased.The result of experiments show that this method is flexible,low cost and meets the requirements for products tests.",
        "keywords": [
            "PID control Virtual instrument PLC Signal acquisition Sensor"
        ],
        "authors": [
            {
                "name": "Sun Dongmei",
                "org": ""
            },
            {
                "name": "Chen Jie",
                "org": ""
            },
            {
                "name": "Huang Xiaodiao",
                "org": ""
            }
        ],
        "venue": "Process Automation Instrumentation",
        "year": 2011
    },
    "02G0s8UW": {
        "id": "02G0s8UW",
        "title": "Research on Tool Wearing Diagnosis of Disk Milling Cutter Based on BP Neural Network",
        "abstract": "Current method was used to monitor the spindle motor current of CNC milling machine,and BP neural network is used to diagnose the tool wear of disk milling cutter.The spindle current signal was processed in order to find the input vectors and corresponding target vectors about BP neural network,and then the BP neural network was designed to realize the diagnosis of tool wear of disk milling cutter.",
        "keywords": [
            "Monitoring Current Method",
            "Tool Wearing",
            "BP Neural Network"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,CHN"
            },
            {
                "name": "ZHANG Chengqiang",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,CHN"
            }
        ],
        "venue": "Manufacturing Technology & Machine Tool",
        "year": 2010
    },
    "egxV1bZE": {
        "id": "egxV1bZE",
        "title": "Statistical Experiment and Data Analysis of Underwater Gun's Muzzle Velocity",
        "abstract": "In order to research the variation regularity of muzzle velocity of the underwater gun bullets,a new measurement method was put forward.A pair of standard coil targets were used to repeatedly measure velocity of bullets at different position within the range of 3 m from muzzle,and the average velocity of different position is used to fit curve.The muzzle velocity and the moving regularity of underwater bullets within the range of 3 m from muzzle were obtained.The dynamic characteristics inconsistency of every coil target can cause the error of measuring velocity while many coils measure at the same time,and the measurement method can avoid the error.The muzzle velocity and the movement rule of underwater bullets within the range of 3 m from muzzle are reliable statistically by the method,and the movement regularity of bullets is true.",
        "keywords": [
            "Bullets",
            "Measurement method",
            "Muzzle velocity",
            "Underwater guns"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "WANG Chang-ming",
                "org": "School of Mechanical Engineering,NUST,Nanjing ,China"
            },
            {
                "name": "HE Yun-feng",
                "org": "School of Mechanical Engineering,NUST,Nanjing ,China"
            },
            {
                "name": "LIU Zhi-jun",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            }
        ],
        "venue": "Journal of Ballistics",
        "year": 2011
    },
    "3dfz4pQA": {
        "id": "3dfz4pQA",
        "title": "Study of data processing method for CNC tool wear monitoring",
        "abstract": "CNC tool wear monitoring would be a great significance for improving the usage rate of CNC and reducing the economic losses due to the tool breakage. The recent research progress on the signal analyzing was reviewed. Some important data process methods were detailed described,such as power spectrum analysis,wavelet transform,artificial neural network and intelligent sensor fusion technology. By comparing their features,the intelligent sensor fusion technology was introduced to be popular in data processing method for CNC tool wear monitoring.",
        "keywords": [
            "CNC",
            "Tool wear monitoring",
            "Data processing method"
        ],
        "authors": [
            {
                "name": "ZENG Xiang-chao",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            }
        ],
        "venue": "Machinery Design & Manufacture",
        "year": 2009
    },
    "LHjvhFLX": {
        "id": "LHjvhFLX",
        "title": "Steel Ball-Raceway Contact Load Distribution in Blade Bearings",
        "abstract": "The engineering practice shows that various kinds of factors such as installation rigid,bolt preloaded force,mounting surface flatness,and etc have significant influence on the operation performance of blade bearings for wind turbine,and the ball-raceway contact load distribution in slewing bearings is the basis of the research in the operating performance,bearing capacity and fatigue life.A finite element modeling method is discussed in which a spring element is used to simulate the ball-raceway contact and the application examples are given.Then,the influence of the installation rigid,bolts preloaded force and mounting surface flatness on the ball-raceway contact load distribution in blade bearings is researched.",
        "keywords": [
            "finite element analysis",
            "contact load distribution",
            "slewing bearing",
            "blade bearing"
        ],
        "authors": [
            {
                "name": "PANG Jian-hua",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "HONG Rong-jing",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "GAO Xue-hai",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            }
        ],
        "venue": "Bearing",
        "year": 2012
    },
    "jX3vSZtl": {
        "id": "jX3vSZtl",
        "title": "Methods of optimization of milling parameters based on wavelet analysis and genetic algorithm",
        "abstract": "Wavelet analysis is used to monitor the tool condition,find out the time when the tool breakage and determine the tool life.Taking the productivity of the processing tool and the tool life as the objective function of genetic algorithm for the global optimization,the most optimized milling parameters is obtained so as to enhance the productivity of the processing tool and the tool life.",
        "keywords": [
            "genetic algorithm",
            "milling parameters",
            "wavelet analysis"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "ZHANG Cheng-qiang",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "ZENG Xiang-chao",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "MA Xu",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            }
        ],
        "venue": "Modern Manufacturing Engineering",
        "year": 2010
    },
    "xNI7ZbX0": {
        "id": "xNI7ZbX0",
        "title": "Research of the Relationship between Tool Wear of CNC Machine Tool and Spindle Current",
        "abstract": "After a brief introduction the importance of tool condition monitoring,the paper derived the relationship between the spindle current and tool wear theoretically.The design of the test current signal detection system,through experiments by the main current and the corresponding tool wear data,using least squares fitting by the linear relationship between the two type.Through the remainder of the standard deviation calculation,test the accuracy of the formula.",
        "keywords": [
            "spindle current",
            "experimental research",
            "amount of tool wear",
            "machine tool",
            "least square",
            "signal detection",
            "standard deviation"
        ],
        "authors": [
            {
                "name": "MA Xu",
                "org": "Center of Metalworking Practice,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            }
        ],
        "venue": "Modular Machine Tool & Automatic Manufacturing Technique",
        "year": 2009
    },
    "UvZSceuk": {
        "id": "UvZSceuk",
        "title": "Research on the methods of temperature measurement of underwater gun",
        "abstract": "Underwater gun is a new kind of arm for underwater combat army.Temperature measurements of its chamber wall and comparing the temperature change launching in the air and underwater have an important meaning for the ballistic model parameters choosing.At the same time,the temperature distribution of chamber wall is helpful for studing chamber burning and prolonging bore life.In order to measure transient wall temperature changes of underwater gun in the launch process,PtRt10-Pt micro-thermocouple and test system are desinged.Wavelet analysis method is used to process test signals.Temperature variation rule of underwater gun in different fix up point is got for the study of the launch process of underwater gun firing and it is the foundation for other studies.",
        "keywords": [
            "underwater gun",
            "chamber wall temperature measurement",
            "wavelet analysis"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "School of Mechanical and power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "WANG Chang-ming",
                "org": "School of Mechanical Engineering,Nanjing University of Science and Technonogy,Nanjing ,China"
            },
            {
                "name": "HE Yun-feng",
                "org": "School of Mechanical Engineering,Nanjing University of Science and Technonogy,Nanjing ,China"
            },
            {
                "name": "WANG Wei",
                "org": "School of Mechanical and power Engineering,Nanjing University of Technology,Nanjing ,China"
            }
        ],
        "venue": "Transducer and Microsystem Technologies",
        "year": 2010
    },
    "HDgx01KF": {
        "id": "HDgx01KF",
        "title": "Monitoring and diagnosis technique on slewing bearing",
        "abstract": "Fault monitoring and diagnosis technology would be a great significance for equipment efficiency and reducing the economic loss due to the slewing bearing failure.Slewing bearing monitoring and diagnosis technique based on vibration,temperature,friction torque,acoustic emission,stress wave were introduced,including the methods of signal processing,especially Hilbert-Huang Transform(HHT),Ensemble Empirical Mode Decomposition-Based Multiscale Principal Component Analysis(EEMD-MSPCA) for local fault signal processing were detailed described.At last,various methods were compared and the intelligent sensor fusion technology of slewing bearing fault diagnosis was forecasted to be a important development direction.",
        "keywords": [
            "fault diagnosis",
            "slewing bearing",
            "fault detection"
        ],
        "authors": [
            {
                "name": "LIU Zhi-jun",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            }
        ],
        "venue": "Modern Manufacturing Engineering",
        "year": 2011
    },
    "IM32G4ka": {
        "id": "IM32G4ka",
        "title": "Research on the relationship between CNC machine tool spindle current and cutting parameters",
        "abstract": "This paper briefly introduced the importance of tool condition monitoring on the main current and tool wear of the linear relationship between the amount and at the same time put forward the spindle current and cutting parameters between the necessary link.Designed to test current signal detection system,the establishment of the spindle current and cutting parameters of the mathematical model of the relationship,and deal with multiple linear regression model to determine the unknown coefficients.Using F-test to verify the model was the establishment of dominance.Through the relative error and standard deviation of the remaining terms,to verify the accuracy of the model is very high,to meet the actual needs of the project.Came to the conclusion that the milling process on the main current of the four factors significantly affect the degree of the weak by the strong order.",
        "keywords": [
            "spindle current",
            "cutting parameters",
            "mathematical model",
            "tool wear"
        ],
        "authors": [
            {
                "name": "MA Xu",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            }
        ],
        "venue": "Machinery",
        "year": 2010
    },
    "eYfwMyxT": {
        "id": "eYfwMyxT",
        "title": "Applied Research of Giant Magneto-resistance Sensor in Cracking Furnace Tubes Carburization Layer Thickness Detection",
        "abstract": "Pyrolysis furnace tubes carburization phenomenon will occur,in the process of pyrolysis oil.When the carburizing gets to a certain depth,it will cause furnace tube materials plastic reduction and brittle fracture,which bring significant economic losses and induced accidents.This paper simulated carburized layer thickness,with iron sheets overlay.The magnetism caused by the irons was detected by the giant magneto-resistance sensor.Based on the principle of eddy current testing it made some experiments about carburizing simulation,and concluded that giant magneto-resistance sensor which has high sensitivity,good reliability is suitable for furnace tubes carburization layer thickness measurement in the detection of the weak magnetic field.",
        "keywords": [
            "detection",
            "giant magneto-resistance sensor",
            "carburized layer thickness"
        ],
        "authors": [
            {
                "name": "HONG Hao",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "GONG Jian-ming",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "CHENG Lei",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            }
        ],
        "venue": "Instrument Technique and Sensor",
        "year": 2010
    },
    "si5i2uSh": {
        "id": "si5i2uSh",
        "title": "Research on Accelerated Fatigue Life Test of Slewing Bearings Used in Wind Turbines",
        "abstract": "Slewing bearings are the key components of wind turbines. Once the failure will bring huge economic losses. Slew ing bearings in wind turbines are always required to service more than 20 years. It is impossible to test slewing bearings according to load conditions. So ALT is the best choice for slewing bearings test to short test time. The paper introduces the basic theory of ALT. Learn the existing slewing bearings test and rolling bearings accelerated life test method. The solution is proposed based on analysis of the problems which may appear in the process of accelerated life test for slewing bearings. The significance of slewing bearings accelerated life is pointed out.",
        "keywords": [
            "accelerated life test",
            "small sample",
            "slewing bearing"
        ],
        "authors": [
            {
                "name": "MENG Rui",
                "org": ""
            },
            {
                "name": "CHEN Jie",
                "org": ""
            },
            {
                "name": "WANG Hua",
                "org": ""
            },
            {
                "name": "GAO Xue-Hai",
                "org": ""
            }
        ],
        "venue": "Modular Machine Tool & Automatic Manufacturing Technique",
        "year": 2013
    },
    "2SPTjXLT": {
        "id": "2SPTjXLT",
        "title": "Reserch on signal processing method of large slewing bearing",
        "abstract": "Large slewing bearing is an important part in a lot of machinery parts,so it is significantto diagnose fault.According to the structure characteristics of slewing ring,it summarizes the existing signal processing methods,in which some new methods are introduced,such as fault diagnosis signal processing method based on the knowledge,processing methods based on genetic algorithm,holographic spectrum signal analysis methods as well as double tree complex wavelet transform method and clustering empirical mode decomposition method based on multi-scale principal component analysis.Then the advantages and disadvantages of these methods are analyzed and compared,and the methods adaptable for dealing with the fault signals of large slewing bearing are proposed.Finally the prospect of signal processing methods that adapt to large slewing bearings is forseen,and Data Fusion is prospected to be the main developing trend.",
        "keywords": [
            "Fault diagnosis",
            "large slewing bearing",
            "Signal processing"
        ],
        "authors": [
            {
                "name": "ZHANG Hui-fang",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            }
        ],
        "venue": "Machinery Design & Manufacture",
        "year": 2012
    },
    "u319p5J6": {
        "id": "u319p5J6",
        "title": "Summary of Slewing Bearing Test Technology and NJUT-I Test System",
        "abstract": "Slewing bearing is usually designed based on the traditional bearing theory,but the calculation parameters are determined by a large number of experimental data,therefore,the experimental directly determines the reliability and accuracy of the design calculation of the slew ing bearing.In this paper,slew ing bearing and its experimental techniques are introduced,then,the design proposal of a test stand for performance testing is discussed,then,the NJUT-I test system is developed.This test system includes the main body,hydraulic system,detection and control systems.The axial force,radial force and overturning moment can be imposed,and a variety of experimental projects can be carried out,such as the carrying capacity,the flexibility,the service life.It can be used for the quality inspection,performance assessment, optimization of the design,and so on.It is of great significance for our slewing bearing industry.",
        "keywords": [
            "performance test",
            "slewing bearing",
            "testing equipment"
        ],
        "authors": [
            {
                "name": "WANG Hua",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "GAO Xue-hai",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            }
        ],
        "venue": "Modular Machine Tool & Automatic Manufacturing Technique",
        "year": 2011
    },
    "eYbytHXQ": {
        "id": "eYbytHXQ",
        "title": "Characterization on Fault Feature Parameters for Slewing Bearings in Wind Turbines",
        "abstract": "The accelerated fatigue life test of a slewing bearing in wind turbine is carried out,the relevancy grade of fault with lubricating grease temperature,frictional and vibration acceleration signal is analyzed,and the parameters are determined to characterize raceway fault of slewing bearings in wind turbines. The occurring time of fault is judged by using the trend of temperature rise,frictional torque and acceleration,which provide the data support for further analysis of the fault of slewing bearings in wind turbines.",
        "keywords": [
            "slewing bearing in wind turbine",
            "frictional torque",
            "vibration acceleration",
            "temperature rise",
            "raceway wear"
        ],
        "authors": [
            {
                "name": "Xu Xin-ting",
                "org": ""
            },
            {
                "name": "Chen Jie",
                "org": ""
            },
            {
                "name": "Wang Hua",
                "org": ""
            },
            {
                "name": "Sun Dong-mei",
                "org": ""
            },
            {
                "name": "Hong Rong-jing",
                "org": ""
            }
        ],
        "venue": "Bearing",
        "year": 2013
    },
    "zOHHCMKI": {
        "id": "zOHHCMKI",
        "title": "Contact stress distribution over raceways of a double row 4-point-contact slewing bearing",
        "abstract": "A double row 4-point-contact slewing bearing is usually applied with strict requirements for reliability.The load distribution over raceways is the fundament to calculate both the static and dynamic bearing capability of a slewing bearing.The paper discussed a method for calculating the load distribution in a double row 4-point-contact slewing bearing under general load conditions(turnover moment,axial load and radial load).Based on the method,some suggestions were proposed for optimization of the slewing bearing design.The method was applied to solve the contact load and stress distribution over raceways of a pitch slewing bearing in a wind power turbine as an example.",
        "keywords": [
            "double row 4-point-contact",
            "load distribution",
            "wind power turbine",
            "slewing bearing"
        ],
        "authors": [
            {
                "name": "GAO Xuehai",
                "org": "College of Mechanical Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "HUANG Xiaodiao",
                "org": "College of Mechanical Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "WANG Hua",
                "org": "College of Mechanical Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Mechanical Engineering,Nanjing University of Technology,Nanjing ,China"
            }
        ],
        "venue": "Journal of Nanjing University of Technology(Natural Science Edition)",
        "year": 2011
    },
    "xC8JuNH3": {
        "id": "xC8JuNH3",
        "title": "Effect of Geometry Parameters on Friction Torque of Four Point Contact Ball Slewing Bearings",
        "abstract": "The factors bringing about the friction are introduced in four point contact ball slewing bearings,and the theoretical calculation formulas of the friction torque between the balls and the raceways are given.The effects of the initial contact angle,raceway curvature coefficient,ball diameter and clearance on friction torque between the balls and the raceways are analyzed.It is found that in order to decrease the friction torque and heat,and improve the life,the parameters of the bearings should be selected as following: the initial contact angle of four point contact ball slewing bearings 50\u00b0~ 60\u00b0,raceway curvature radius coefficient 0.53~0.54,clearance-0.01~0.01mm and smaller ball diameter.",
        "keywords": [
            "four point contact ball bearing",
            "slewing bearing",
            "friction torque"
        ],
        "authors": [
            {
                "name": "Lu Jing",
                "org": "Department of Mechanical Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "Hong Rong-jing",
                "org": "Department of Mechanical Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "Chen Jie",
                "org": "Department of Mechanical Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "Gao Xue-hai",
                "org": "Department of Mechanical Engineering,Nanjing University of Technology,Nanjing ,China;Shanghai OujiKete Slewing Bearing Co.,Ltd.,Shanghai ,China"
            }
        ],
        "venue": "Bearing",
        "year": 2013
    },
    "4Ebe0g31": {
        "id": "4Ebe0g31",
        "title": "Design and Realization of Measurement System for Intelligent Slewing Bearings Used in Wind Turbines Based on Wireless Transmission",
        "abstract": "Using the NI digital data acquisition card and wireless transmission communication,realize the online monitoring of slewing bearings which integrated various types of sensors in the bearings.The test system is able to achieve high speed and low speed signal acquisition within a distance of 60m,and the system allows a plurality of wireless network.The PC is used to realize data acquisition,storage,processing,analysis and effective extraction of early fault signals and intelligent oiling and alarm control.",
        "keywords": [
            "wireless transmission",
            "test system",
            "intelligent bearing",
            "virtual instrument",
            "slewing bearing"
        ],
        "authors": [
            {
                "name": "Fang Cheng-gang",
                "org": "School of Mechanical Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "Chen Jie",
                "org": "School of Mechanical Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "Xie Dong-hua",
                "org": "School of Mechanical Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "Sun Dong-mei",
                "org": "School of Mechanical Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "Wang Hua",
                "org": "School of Mechanical Engineering,Nanjing University of Technology,Nanjing ,China"
            }
        ],
        "venue": "Bearing",
        "year": 2012
    },
    "rD8yxJDv": {
        "id": "rD8yxJDv",
        "title": "Service life extension method of slewing bearing based on intelligent motion control",
        "abstract": "A new service life extension method was proposed based on the intelligent motion control.A motion control model was established based on the torque-based neural network impedance control,then the simulation and comparison with traditional control method were performed.The results show that this new controller perfectly matchs the load changing,lowers the probability of damage occurrence and damage growth rate,then the service life of slewing bearing is extended.",
        "keywords": [
            "neural network",
            "adaptive",
            "service-life extension",
            "impedance control",
            "slewing bearing"
        ],
        "authors": [
            {
                "name": "XIE Donghua",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "WANG Hua",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "HONG Rongjing",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            }
        ],
        "venue": "Journal of Central South University(Science and Technology)",
        "year": 2013
    },
    "KnqKZtOf": {
        "id": "KnqKZtOf",
        "title": "Development of on-line monitoring system for CNC tool fault diagnosis",
        "abstract": "After introducing the basic theory of wavelet analysis,LabVIEW,and its software workbench,various methods of the application of wavelet de-noising and singular signal detection to fault diagnosis and its combination with LabVIEW application to signal processing were instructed in detail. A fault diagnosis system based on LabVIEW 8.2 which has the abilities of collection,analysis and process,has been designed for CNC tool wear on-line measuring and real-time fault diagnosis. Combined with the experiment of CNC tool wear fault diagnosis,the rationality and practicability of the idea\u2019s application in actual project was certified.",
        "keywords": [
            "Fault diagnosis",
            "Virtual instrument",
            "Wavelet analysis",
            "Tool wear"
        ],
        "authors": [
            {
                "name": "ZENG Xiang-chao",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            }
        ],
        "venue": "Machinery Design & Manufacture",
        "year": 2009
    },
    "oCbJRdmm": {
        "id": "oCbJRdmm",
        "title": "Design of testing table control system used for wind power slewing bearing based on PLC",
        "abstract": "Testing table used for wind power slewing bearing is discussed,which is introduced simply first.Then,some contents are expounded,such as principle and structure of control system,program design in lower computer,program design in upper computer and experimental process.The realization of software is given for example by free-port communication.On the other hand,control values are converse solved to reduce the nonlincarity effect of system produced by proportional valve.",
        "keywords": [
            "Wind power",
            "Slewing bearing",
            "Control system",
            "Testing table"
        ],
        "authors": [
            {
                "name": "ZHU Fei",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "HONG Rong-jing",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "GAO Xue-hai",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "DAI Ke-fang",
                "org": "Maanshan Fangyuan Slewing Ring Company Limited,Maanshan ,China"
            }
        ],
        "venue": "Machinery Design & Manufacture",
        "year": 2011
    },
    "6Py3wkTg": {
        "id": "6Py3wkTg",
        "title": "Characteristic research on giant magneto-resistance sensor in furnace tube carburizing thickness detecting",
        "abstract": "In the process of cracking furnace tube crack petroleum,it will occur carburizing phenomenon.When the furnace tube carburize to a certain depth,it will brittle rupture and its plastic will be decrease,Therefore,it will lead to great economic losses and induce security accidents.Giant magneto-resistance sensor is selected for magnetic detection by using the method of increasing carburizing layer thickness to increase the magnetic.In the condition of AC excitation,by using the iron plate to simulate the change of carburizing layer thickness,the characteristic of giant magneto-resistance sensor including the excitation frequency,terminal effect and lift-off effect are studied.It provides a theory basis for detecting instrument design.",
        "keywords": [
            "carburized layer thickness detecting",
            "giant magneto-resistance(GMR) sensor",
            "characteristic research"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China;Key Laboratory for Digital Manufacturing of Industrial Equipment and Control Technology,Nanjing ,China"
            },
            {
                "name": "GONG Jian-ming",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China;Key Laboratory for Digital Manufacturing of Industrial Equipment and Control Technology,Nanjing ,China"
            },
            {
                "name": "CHENG Lei",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China;Key Laboratory for Digital Manufacturing of Industrial Equipment and Control Technology,Nanjing ,China"
            },
            {
                "name": "WANG Wei",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China;Key Laboratory for Digital Manufacturing of Industrial Equipment and Control Technology,Nanjing ,China"
            }
        ],
        "venue": "Transducer and Microsystem Technologies",
        "year": 2010
    },
    "UjmEtDkO": {
        "id": "UjmEtDkO",
        "title": "Hydraulic Loading System of the Wind Rotary Bearing Test Bench Based on AMESim-Simulink Co-simulation",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "YANG Chun",
                "org": ""
            },
            {
                "name": "HONG Rong-jing",
                "org": ""
            },
            {
                "name": "CHEN Jie",
                "org": ""
            },
            {
                "name": "PANG Jian-hua",
                "org": ""
            }
        ],
        "venue": "Chinese Hydraulics & Pneumatics",
        "year": 2013
    },
    "AX40Y5th": {
        "id": "AX40Y5th",
        "title": "Key technology in NC machining of subdivision surface",
        "abstract": "The key technology in NC machining of triangular field and quadrilateral subdivision surface is discussed,which includes the subdivision surface model of NC machining,the fence mesh generation algorithm in rough processing,the two methods commonly used in NC tool path generation,the offset mesh calculation algorithm in finish machining and the offset error control method. The practical examples are given also. At last,the further study which will solve the practical use of NC machining of subdivision surface is pointed out.",
        "keywords": [
            "Offset mesh",
            "Subdivision surface",
            "NC machining",
            "Fence mesh",
            "NC tool path"
        ],
        "authors": [
            {
                "name": "YUAN Hong",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "FANG Cheng-gang",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "WANG Hua",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            }
        ],
        "venue": "Machinery Design & Manufacture",
        "year": 2010
    },
    "F0sGZz6z": {
        "id": "F0sGZz6z",
        "title": "The portable data acquisition system of cutting tool condition monitoring based on LabVIEW & wavelet analysis",
        "abstract": "A portable data acquisition system of cutting tool condition monitoring is constructed in the paper. Based on LabVIEW8.2 of virtual instrument and USB technology, the system design ideas of portable DAQ on hardware and software is discussed. The development ideas of measuring application program were explained. Real-time multiple channels data acquisition and preservation, data processing and analyzing, data querying and waveform display, test report generation and print were confirmed in an actual project.",
        "keywords": [
            "condition monitoring",
            "cutting tools",
            "data acquisition",
            "virtual instrumentation",
            "wavelet transforms",
            "LabVIEW",
            "USB technology",
            "cutting tool condition monitoring",
            "data acquisition system",
            "virtual instrument",
            "wavelet analysis",
            "Data acquisition",
            "LabVIEW",
            "Tool wear",
            "wavelet Analysis"
        ],
        "authors": [
            {
                "name": "Chen Jie",
                "org": "Nanjing Univ. of Technol., Nanjing, China|c|"
            },
            {
                "name": "Zeng Xiangchao",
                "org": ""
            },
            {
                "name": "Zhang Chengqiang",
                "org": ""
            }
        ],
        "venue": "ICCASM), 2010 International Conference",
        "year": 2010
    },
    "v0v62ey4": {
        "id": "v0v62ey4",
        "title": "The research on tool wear diagnosing method of disk milling cutter",
        "abstract": "The disk milling cutter and fractal peculiarity of milling process,the signal acquisition and processing method are analyzed for the high speed CNC milling gear machine.The current method was used to monitor the spindle motor current of CNC milling machine,and BP neural network is used to diagnose the tool wear of disk milling cutter.The spindle current signal was processed in order to find the input vectors and corresponding target vectors about BP neural network,and then the BP neural network was designed to realize the diagnosis of tool wear of disk milling cutter.",
        "keywords": [
            "tool wearing",
            "BP neural network",
            "monitoring current method"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "ZHANG Cheng-qiang",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "MA Xu",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            }
        ],
        "venue": "Modern Manufacturing Engineering",
        "year": 2011
    },
    "Ca92Szcj": {
        "id": "Ca92Szcj",
        "title": "Access to Database Based on LabVIEW in Slewing Bearing Testing and Control System",
        "abstract": "Taking a slewing bearing tester stand as the studying subject,according to the deficiencies of LabVIEW connecting to databases,experiment data interchange and the actual need of data processing of slewing bearing testing and control system,a method using saddlebag-LabSQL is proposed to visit SQL Server in LabVIEW.In this paper,some contents are introduced,such as slewing bearing testing and control system,design of multi-level relationship about tables in SQL Server and exchange visits between LabVIEW and SQL Server.",
        "keywords": [
            "SQL Server",
            "slewing bearing",
            "LabVIEW"
        ],
        "authors": [
            {
                "name": "ZHU Fei",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "HONG Rong-jing",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "GAO Xue-hai",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "DAI Ke-fang",
                "org": "Maanshan Fangyuan Slewing Ring Company Limited,Maanshan ,China"
            }
        ],
        "venue": "Bearing",
        "year": 2010
    },
    "SLDcrj3g": {
        "id": "SLDcrj3g",
        "title": "The Practice and Discussion in Teaching Application Based on EDA Technology",
        "abstract": "The EDA technology in the electronic teaching of courses is discussed,so students in the teaching curriculum,under the guidance of the teachers,can put forward into the actual project and the completion of the course design.And the courses preaching are replaced by the large number of substantive contents.Study results have markedly improved.It is proved that EDA technology in the classroom teaching in the validity and feasibility.",
        "keywords": [
            "EDA Technology",
            "computer-aided in instruction"
        ],
        "authors": [
            {
                "name": "SUN Dong-mei",
                "org": "Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Nanjing University of Technology,Nanjing ,China"
            }
        ],
        "venue": "Higher Education Forum",
        "year": 2008
    },
    "vPkTiDaM": {
        "id": "vPkTiDaM",
        "title": "Study of monitoring method for CNC tool wear",
        "abstract": "CNC tool wear monitoring has great importance in improving the utilization of CNC machine tools and in reducing the economic lossos due to the tool breakage. This article is well targeted in reviewing several researches on the study of various tool wear monitoring method at home and abroad. Six tool wear monitoring methods are described in detail, which are the cutting force monitoring, the cutting noise monitoring, the power monitoring, the sound launch monitoring, the electric current monitoring as well as the monitoring method based on the multi-sensor monitor. Comparing with the merits and demerits of each monitoring methods, the article suggests that the monitoring method based on the multi-sensor monitor would be the main direction of the development of CNC tool wear monitoring in the future.",
        "keywords": [
            "CNC",
            "tool wear monitoring",
            "Monitoring method"
        ],
        "authors": [
            {
                "name": "MA Xu",
                "org": "1.Center of Metalworking Practice,Nanjing University of Technology,Nanjing , China"
            },
            {
                "name": "CHEN Jie",
                "org": " 2.School of Mechanical and Power Engineering, Nanjing University of Technology, Nanjing , China"
            }
        ],
        "venue": "Machinery",
        "year": 2009
    },
    "LPmnkoR3": {
        "id": "LPmnkoR3",
        "title": "A Simplify Method and Verification with FEM for Bolt Connection of Large-Scale Structure",
        "abstract": "A simplified method for FEM model of bolt connection with large-scale structure is optimized,which is only required to apply uniform pressure on the FEM model,and no modeling for all bolts is required.The method not only improves the convergence rate in FEM calculation,but also reduces the costs of the FEM simulation.The hypothesis of the simplified method is analyzed in detail.A simplified model of a kind of bolt connection using the simplify method is established to verify the accuracy and credibility of this modus.The crucial characteristic quantity and the contact stress nephograms of the simplified model are calculated under three different load conditions,which will contrast with those calculated in the traditional modeling.The applicable conditions of the simplify method are obtained by discussing those comparison.",
        "keywords": [
            "Simplified Model",
            "Bolt Connection",
            "FEM"
        ],
        "authors": [
            {
                "name": "SHEN Yi",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "HONG Rong-jing",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "GAO Xue-hai",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "WANG Hua",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            }
        ],
        "venue": "Machinery Design & Manufacture",
        "year": 2012
    },
    "bzeAvER8": {
        "id": "bzeAvER8",
        "title": "Optimization Methods of Milling Parameters Based on Genetic Algorithm",
        "abstract": "To improve tool life and reduce processing cost,the parameters in the milling process should be optimized.The method of motor current monitoring was used to monitor the wear condition of tool. The experiments were designed using orthogonal experiment method. The measured data were dealt with by MATLAB. A mathematical formula was established between milling parameters and tool life. The mathematical formula and production cost were taken as a mathematical model. The mathematical model was optimized through genetic algorithms to obtain the most optimized milling parameters.",
        "keywords": [
            "Orthogonal experiment",
            "Genetic algorithm",
            "Optimization"
        ],
        "authors": [
            {
                "name": "ZHANG Chengqiang",
                "org": "Key Laboratory of Digital Manufacturing for Industrial Equipment and Control Technology,Nanjing University of Technology,Nanjing Jiangsu ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Key Laboratory of Digital Manufacturing for Industrial Equipment and Control Technology,Nanjing University of Technology,Nanjing Jiangsu ,China"
            },
            {
                "name": "MA Xu",
                "org": "Metalworking Practice Center,Nanjing University of Technolog,Nanjing Jiangsu ,China"
            }
        ],
        "venue": "Machine Tool & Hydraulics",
        "year": 2010
    },
    "VxSPUTjl": {
        "id": "VxSPUTjl",
        "title": "Portable Data Acquisition System of Cutting Tool Condition Monioring Based on LabVIEW & Wavelet Analysis",
        "abstract": "A portable data acquisition system of cutting tool condition monitoring was constructed based on LabVIEW8.2 platform of virtual instrument and USB bus technology,and the system design ideas of portable DAQ on hardware and software were discussed.The design project and principle diagrams of data acquisition module and communication block of USB were given.The development ideas of measuring application program were explained.Real-time multiple channels data acquisition and preservation,data processing and analyzing,query data and waveform display,test report generation and print were certified in actual project.",
        "keywords": [
            "Tool wear",
            "Data acquisition",
            "LabVIEW"
        ],
        "authors": [
            {
                "name": "ZENG Xiangchao",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing Jiangsu ,China"
            },
            {
                "name": "MA Xu",
                "org": "Center of Metalworking Practice,Nanjing University of Technology,Nanjing Jiangsu ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing Jiangsu ,China"
            }
        ],
        "venue": "Machine Tool & Hydraulics",
        "year": 2009
    },
    "HoubDyDO": {
        "id": "HoubDyDO",
        "title": "Characteristics of giant magneto-resistance sensor in simulation experiments for measuring carburization thickness of furnace tube",
        "abstract": "Furnace tube could generate carburizing phenomenon in the process of pyrolysis of oil.Giant magneto-resistance(GMR) sensor was used to detect the magnetism with the furnace pipe carburizing layer thickness to cause the increase of magnetic.Under the condition of alternating current excitation,the excitation frequency,the magnetic susceptibility direction,and the positive and negative work strokes of the probe for GMR sensor were studied by using sheet iron to simulate the variations of carburizing layer thickness.Results showed that the best excitation frequency was 40-200 Hz,and the element of GMR sensor was vertical to the external wall of the cracking furnace tube,when GMR sensor was used in the weak magnetic field.The sensors could response different thicknesses and output organized incremental or decreasing voltages.",
        "keywords": [
            "giant magneto-resistance(GMR) sensor",
            "carburized layer thickness",
            "characteristic research"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "GONG Jian-ming",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "CHENG Lei",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            },
            {
                "name": "ZHANG Hui-fang",
                "org": "College of Mechanical and Power Engineering,Nanjing University of Technology,Nanjing ,China"
            }
        ],
        "venue": "Journal of Nanjing University of Technology(Natural Science Edition)",
        "year": 2010
    },
    "tmY17TGW": {
        "id": "tmY17TGW",
        "title": "The role of elevated serum procalcitonin in neuroendocrine neoplasms of digestive system.",
        "abstract": "Elevated serum procalcitonin (PCT) was reported in patients with certain type of neuroendocrine neoplasms (NENs).The aim of this study was to assess the role of elevated serum PCT in NENs from digestive system.Serum PCT and serum CgA level were measured in 155 patients with NENs from digestive system.Elevated serum PCT was found in 63 patients (40.6%). Grade 3 disease was a significant factor associated with elevated serum PCT (OR, 9.24; 95%CI, 3.04-28.08; P<0.001). Serum PCT level was significantly decreased after treatment both in patients with stable disease (P=0.003) and patients with partial remission (P=0.001). In these patients, serum PCT level significantly increased again at the time of progression disease (P=0.001). Elevated serum PCT was a significant factor of worse survival (HR, 2.86; 95%CI, 1.36-6.03; P=0.006). Compared with patients with normal serum PCT and CgA level, patients with either PCT or CgA elevated and patients with both PCT and CgA elevated had progressively worse survival. Additionally, PCT expression in tumor cells was found in 24.0% of patients but did not correlate with other clinicopathological factors, including serum PCT.Serum PCT is elevated in part of patients with NENs of digestive system, especially in patients with grade 3 disease. Serum PCT level can help evaluate treatment response and its elevation indicates poor prognosis. Combination of serum PCT and CgA can improve outcome prediction.",
        "keywords": [
            "Biomarker",
            "Neuroendocrine neoplasms",
            "Procalcitonin",
            "Prognosis"
        ],
        "authors": [
            {
                "name": "Luohai Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan II Road, Yuexiu District, Guangzhou, China, 510080."
            },
            {
                "name": "Yu Zhang",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan II Road, Yuexiu District, Guangzhou, China, 510080."
            },
            {
                "name": "Yuan Lin",
                "org": "Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan II Road, Yuexiu District, Guangzhou, China, 510080."
            },
            {
                "name": "Langhui Deng",
                "org": "Department of Laboratory Medicine, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan II Road, Yuexiu District, Guangzhou, China, 510080."
            },
            {
                "name": "Shiting Feng",
                "org": "Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan II Road, Yuexiu District, Guangzhou, China, 510080."
            },
            {
                "name": "Minhu Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan II Road, Yuexiu District, Guangzhou, China, 510080."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan II Road, Yuexiu District, Guangzhou, China, 510080."
            }
        ],
        "venue": "Clinical biochemistry",
        "year": 2017
    },
    "nv825b1h": {
        "id": "nv825b1h",
        "title": "Sunitinib for unresectable or metastatic gastroenteropancreatic neuroendocrine neoplasm: A single-institution retrospective study in China",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Qiuchen Yang",
                "org": "Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China"
            },
            {
                "name": "Yuhong Wang",
                "org": "Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China"
            },
            {
                "name": "Ling Xue",
                "org": "Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"
            },
            {
                "name": "Zi-Ping Li",
                "org": ""
            },
            {
                "name": "Minhu Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China"
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Pancreatology",
        "year": 2016
    },
    "m0HhMBKb": {
        "id": "m0HhMBKb",
        "title": "Phase I dose-escalation study of thoracic radiotherapy in combination with gefitinib in patients with IIIB/IV non-small cell lung cancer (NCT00497250)",
        "abstract": "e14581 Background: Cinical studies have confirmed that gefitinib, an EGFR-TKI, is effective for some advanced NSCLC patients. Patients with Asian ethnicity are reported to have a higher response rate with gefitinib monotherapy. However, a higher incidence of interstitial lung disease, sometimes lethal, is also found. The combination of gefitinib and radiotherapy has been observed to have a synergistic, anti-proliferative effect against NSCLC in vitro. This phase I study assessed the safety, clinical feasibility and optimally tolerated regimen (OTR) of this combination in patients with pretreated locally advanced or metastatic (IIIB/IV) NSCLC. Methods: Patients with stage IIIB or selected stage IV, failure of platinum-based chemotherapy regimen NSCLC were eligible. Four Cohorts of eight patients each were planned to be treated with escalating doses from 54 to 60 Gy of conformal or intensity- modulated radiotherapy (2Gy/Fx) administered in combination with gefitinib 250mg daily during RT and 60 days after t...",
        "keywords": "",
        "authors": [
            {
                "name": "M. Fan",
                "org": ""
            },
            {
                "name": "L. Xie",
                "org": ""
            },
            {
                "name": "Xiaowei Xu",
                "org": ""
            },
            {
                "name": "G. Zhang",
                "org": ""
            },
            {
                "name": "Jiayi Chen",
                "org": ""
            },
            {
                "name": "X. Fu",
                "org": ""
            },
            {
                "name": "X. Zhou",
                "org": ""
            },
            {
                "name": "Wei Li",
                "org": ""
            },
            {
                "name": "Gening Jiang",
                "org": ""
            }
        ],
        "venue": "Journal of Clinical Oncology",
        "year": 2016
    },
    "LAIMVOuI": {
        "id": "LAIMVOuI",
        "title": "Expression and clinical significance of alpha-internexin in gastroenteropancreatic neuroendocrine neoplasm",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yuhong Wang",
                "org": "Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"
            },
            {
                "name": "Yuan-Jia Chen",
                "org": "Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China"
            },
            {
                "name": "Minhu Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Pancreatology",
        "year": 2016
    },
    "gAuP8F71": {
        "id": "gAuP8F71",
        "title": "MicroRNA-34a-5p enhances sensitivity to chemotherapy by targeting AXL in hepatocellular carcinoma MHCC-97L cells",
        "abstract": "Mature microRNA (miRNA) 34a-5p, which is a well-known tumor suppressor in hepatitis virus-associated hepatocellular carcinoma (HCC), plays an important role in cell processes, such as cell proliferation and apoptosis, and is therefore an optimal biomarker for future clinical use. However, the role of miRNA-34a-5p in chemoresistance has yet to be identified. In the present study, the expression of miRNA-34a-5p was assessed by an  hybridization assay in HCC tissues and was found to be significantly decreased compared with the pericarcinomatous areas of the tissue specimens, which consisted of samples obtained from 114 patients with HCC. High expression of miRNA-34a-5p was found to be associated with a favorable overall survival time in HCC patients. Functional tests performed by transfecting miRNA-34a-5p mimics or inhibitors into MHCC-97L cells illustrated that miRNA-34a-5p inhibited proliferation, elevated apoptosis and decreased chemoresistance to cisplatin in HCC cells. AXL is the direct target of miRNA-34a-5p, as confirmed by sequence analysis and luciferase assay. Transfection of the cells with small interfering RNA for AXL (siAXL) increased the apoptosis ratio of the MHCC-97L cell line. Transfection with siAXL led to similar biological behaviors in the MHCC-97L cells to those induced by ectopic expression of miRNA-34a-5p. Thus, it was concluded that miRNA-34a-5p enhanced the sensitivity of the cells to chemotherapy by targeting AXL in hepatocellular carcinoma. In addition, low expression of miRNA-34a-5p in HCC tissues yielded an unfavorable prognosis for patients with HCC that received radical surgery, due to the promotion of proliferation and an increase in chemoresistance in HCC cells.",
        "keywords": [
            "AXL",
            "chemoresistance",
            "cisplatin",
            "hepatocellular carcinoma",
            "microRNA34a-5p"
        ],
        "authors": [
            {
                "name": "xiao yun li",
                "org": "sun yat sen university"
            },
            {
                "name": "j y wen",
                "org": "sun yat sen university"
            },
            {
                "name": "chang chang jia",
                "org": "sun yat sen university"
            },
            {
                "name": "t t wang",
                "org": "sun yat sen university"
            },
            {
                "name": "min dong",
                "org": "sun yat sen university"
            },
            {
                "name": "qu lin",
                "org": "sun yat sen university"
            },
            {
                "name": "z h chen",
                "org": "sun yat sen university"
            },
            {
                "name": "x k ma",
                "org": "sun yat sen university"
            },
            {
                "name": "li wei",
                "org": "sun yat sen university"
            },
            {
                "name": "z x lin",
                "org": "sun yat sen university"
            },
            {
                "name": "d y ruan",
                "org": "sun yat sen university"
            },
            {
                "name": "jie chen",
                "org": "sun yat sen university"
            },
            {
                "name": "d h wu",
                "org": "sun yat sen university"
            },
            {
                "name": "wei liu",
                "org": "sun yat sen university"
            },
            {
                "name": "yan tai",
                "org": "sun yat sen university"
            },
            {
                "name": "zhi yong xiong",
                "org": "sun yat sen university"
            },
            {
                "name": "x y wu",
                "org": "sun yat sen university"
            },
            {
                "name": "qi zhang",
                "org": "sun yat sen university"
            }
        ],
        "venue": "Oncology letters",
        "year": 2015
    },
    "TeXBlvFX": {
        "id": "TeXBlvFX",
        "title": "Comparison of five staging systems in predicting the survival rate of patients with hepatocellular carcinoma undergoing trans-arterial chemoembolization therapy.",
        "abstract": "The majority of patients with unresectable hepatocellular carcinoma (HCC) undergo trans-arterial chemoembolization (TACE). However, the prognosis of HCC remains poor. In the present study, five staging systems were compared to predict the survival rate of patients with HCC undergoing TACE treatment. A total of 220 patients with HCC were examined according to the model to estimate survival for hepatocellular carcinoma (MESH), hepatoma arterial embolization prognostic score (HAP), modified HAP (mHAP), performance status combined Japan Integrated Staging system (PSJIS) and tumor-node-metastasis (TNM) staging systems. The endpoints of the study were 3-month survival, 6-month survival, 1-year survival and overall survival (OS) rates. Receiver operating characteristic curve analysis indicated that the area under the curve of MESH, HAP, mHAP, PSJIS and TNM was 0.858, 0.728, 0.690, 0.688 and 0.699, respectively, in predicting 3-month survival rates; 0.822, 0.747, 0.720, 0.722 and 0.715, respectively, in predicting 6-month survival rates and 0.725, 0.664, 0.672, 0.645 and 0.654, respectively, in predicting 1-year survival rates. Discriminatory ability, homogeneity, monotonicity and prognostic stratification ability was evaluated using a likelihood ratio test and Akaike information criterion values among the five staging systems, and revealed that the MESH system was the optimal prognostic staging system for HCC. In conclusion, the results of the present study suggest that the MESH system is the most accurate prognostic staging system of 3-month survival, 6-month survival, 1-year survival and OS rates among the five systems analyzed in patients with HCC who have received TACE treatment.",
        "keywords": [
            "hepatitis B",
            "hepatocellular carcinoma",
            "model to estimate survival for hepatocellular carcinoma",
            "prognosis",
            "trans-arterial chemoembolization"
        ],
        "authors": [
            {
                "name": "Zhan-Hong Chen",
                "org": "Department of Medical Oncology of Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China."
            },
            {
                "name": "Ying-Fen Hong",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Xiangwei Chen",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Qu Lin",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Jinxiang Lin",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Xing Li",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Jing-Yun Wen",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Dan-Yun Ruan",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Min Dong",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Li Wei",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Tian-Tian Wang",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Ze-Xiao Lin",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Xiao-Kun Ma",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Dong-Hao Wu",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Xiang-Yuan Wu",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Ruihua Xu",
                "org": "Department of Medical Oncology of Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China."
            }
        ],
        "venue": "Oncology letters",
        "year": 2018
    },
    "POTwOQE5": {
        "id": "POTwOQE5",
        "title": "Autophagic LC3B overexpression correlates with malignant progression and predicts a poor prognosis in hepatocellular carcinoma.",
        "abstract": "Autophagy is a process that involves lysosomal degradations of cellular organelles and closely related to tumor occurrence and progression. However, its importance in hepatocellular carcinoma (HCC) was still controversial. Therefore, this study is aimed to address the clinicopathologic effect of microtubule-associated protein 1 light chain 3B (LC3B) and Beclin-1, as autophagic markers, in HCC patients. Tissue microarray-based immunohistochemistry was used to examine the expression of LC3B and another autophagy key regulator (Beclin-1) in 156 operable HCC patients. Kaplan-Meier analysis, chi-square test, and Spearman's correlation analysis were used to analyze correlation of LC3B and Beclin-1 and their influence on clinical characteristics and prognosis. We found that the expression level of LC3B was significantly associated with vascular invasion (P\u2009=\u20090.008), lymph node metastasis (P\u2009&amp;lt;\u20090.001), and Beclin-1 expression level (P\u2009&amp;lt;\u20090.001). However, LC3B was not related to other clinicopathological features, including hepatitis B virus infection, liver cirrhosis, tumor number, tumor size, pathology grade, and tumor-node-metastasis (TNM) stage. Besides, correlation between the expression of Beclin-1 and clinicopathological features were not identified. Survival analysis showed that patients with high LC3B expression had a poorer 5-year overall survival (OS) rate than those with low LC3B expression (high vs. low: 79.5\u00a0% vs. 20.5\u00a0%, P\u2009=\u20090.026). And high LC3B expression tended to be related with shorter progression-free survival (PFS) (P\u2009=\u20090.074), whereas the expression level of Beclin-1 did not show statistically significant association with OS or PFS. Further multivariate analysis revealed that lymph node metastasis (P\u2009=\u20090.047) and LC3B expression level (P\u2009=\u20090.047) were independent factors to predict the prognosis of OS in all patients. Our study demonstrated that high expression of LC3B, correlated with vascular invasion and lymph node metastasis, might be a novel prognostic biomarker and would be a potential therapy target for HCC, especially in operable patients.",
        "keywords": [
            "Hepatocellular carcinoma",
            "LC3B",
            "Beclin-1",
            "Vascular invasion",
            "Lymph node metastasis",
            "Prognostic biomarker"
        ],
        "authors": [
            {
                "name": "Dong-Hao Wu",
                "org": "Department of Medical Oncology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China."
            },
            {
                "name": "Chang-Chang Jia",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Ze-Xiao Lin",
                "org": ""
            },
            {
                "name": "Dan-Yun Ruan",
                "org": ""
            },
            {
                "name": "Xing Li",
                "org": ""
            },
            {
                "name": "Qu Lin",
                "org": ""
            },
            {
                "name": "Min-Dong",
                "org": ""
            },
            {
                "name": "Xiao-Kun Ma",
                "org": ""
            },
            {
                "name": "Xiang-Bo Wan",
                "org": ""
            },
            {
                "name": "Na Cheng",
                "org": ""
            },
            {
                "name": "Zhan-Hong Chen",
                "org": ""
            },
            {
                "name": "Yan-Fang Xing",
                "org": ""
            },
            {
                "name": "Xiang-Yuan Wu",
                "org": ""
            },
            {
                "name": "Jing-Yun Wen",
                "org": ""
            }
        ],
        "venue": "Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine",
        "year": 2014
    },
    "MIgPEK9h": {
        "id": "MIgPEK9h",
        "title": "Albumin-to-Alkaline Phosphatase Ratio as an Independent Prognostic Factor for Overall Survival of Advanced Hepatocellular Carcinoma Patients without Receiving Standard Anti-Cancer Therapies.",
        "abstract": "Background Albumin-to-Alkaline Phosphatase Ratio (ALB/ALP ratio, AAPR), a newly developed index of liver function, has been rarely discussed about its prognostic value in malignancies. The current study attempted to evaluate the prognostic prediction of AAPR in advanced HCC. Methods 237 advanced HCC patients who refused any standard anti-cancer therapies were retrospectively analyzed. The threshold value of AAPR was determined by receiver operating characteristic (ROC) curve. Univariate analyses using Kaplan-Meier method and log-rank test, and multivariate analysis using Cox proportional hazards regression model were conducted. Comparisons of ROC curves and likelihood ratio test (LRT) were utilized to compare the value of different factors in predicting survival. Results ROC curve analysis confirmed 0.38 as the optimal cutoff value of AAPR in evaluating overall survival (OS). Patients with an AAPR > 0.38 exhibited significantly lower frequencies of ascites, portal vein tumor thrombus, Child-Pugh grade B & C, and KPS < 70 (all P < 0.05). These patients also displayed a longer median survival time than those with an AAPR \u2264 0.38 (5.8 m vs 2.4 m, P < 0.01). Univariate and multivariate analyses identified AAPR as an independent prognostic indicator (HR = 0.592, P = 0.007). Furthermore, we integrated AAPR with TNM system and found that area under curve of AAPR-TNM system was significantly larger than that of TNM system when predicting 3-month survival (0.670 vs 0.611, P < 0.01). Moreover, LRT indicated that AAPR-TNM system had a significantly larger \u03c72 (26.4 vs 16.4, P < 0.01) and a significantly smaller Akaike information criterion value (1936 vs 1948, P < 0.01) comparing with TNM system. Conclusions Our study implied that AAPR was a potentially valuable prognostic index for advanced HCC patients without receiving any standard anti-cancer therapies. AAPR-TNM system preceded TNM system in predicting overall survival in this study.",
        "keywords": [
            "advanced hepatocellular carcinoma",
            "albumin-to-alkaline phosphatase ratio",
            "biomarkers.",
            "hepatic function reserve",
            "prognosis"
        ],
        "authors": [
            {
                "name": "Xiurong Cai",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Zhanhong Chen",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Xiaokun Ma",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Mingjun Bai",
                "org": "Department of Intervention and Radiology, Guangdong Key Laboratory of Liver Disease, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Tiantian Wang",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Xiangwei Chen",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Donghao Wu",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Li Wei",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Xing Li",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Qu Lin",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Jingyun Wen",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Danyun Ruan",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Zexiao Lin",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Min Dong",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Xiangyuan Wu",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            }
        ],
        "venue": "Journal of Cancer",
        "year": 2018
    },
    "ZF1pvgmp": {
        "id": "ZF1pvgmp",
        "title": "Endoplasmic reticulum stress induced Lox-1+ CD15+ polymorphonuclear myeloid-derived suppressor cells in hepatocellular carcinoma.",
        "abstract": "A recent study indicated that Lectin-type oxidized LDL receptor-1 (LOX-1) was a distinct surface marker for human polymorphonuclears myeloid-derived suppressor cells (PMN-MDSC). The present study was aimed to investigate the existence LOX-1 PMN-MDSC in hepatocellular carcinoma (HCC) patients.127 HCC patients, 10 patients with mild active chronic hepatits B, 10 liver cirrhosis due to hepatitis B, 10 liver dysplastic node with hepatitis B and 50 health control were included.LOX-1+ CD15+ PMN-MDSC were significantly elevated in HCC patients compared with healthy control and patients with benign diseases. LOX-1+ CD15+ PMN-MDSC in circulation were positively associated with those in HCC tissues. LOX-1+ CD15+ PMN-MDSCs significantly reduced proliferation and IFN-\u03b3 production of T cells with a dosage dependent manner with LOX-1- CD15+ PMNs reached negative results. The suppression on T cell proliferation and IFN-\u03b3 production was reversed by ROS inhibitor and Arginase inhibitor. ROS level and activity of arginase of LOX-1+ CD15+ PMN were higher in LOX-1+ CD15+ PMN-MDSCs than LOX-1- CD15+ PMNs, as well as the expression of the NADPH oxidase NOX2 and arginase I. RNA sequence revealed that LOX-1+ CD15+ PMN-MDSCs displayed significantly higher expression of spliced X-box-binding protein 1 (sXBP1), an endoplasmic reticulum (ER) stress marker. ER stress inducer induced LOX-1 expression and suppressive function for CD15+ PMN from health donor. For HCC patients, LOX-1+ CD15+ PMN-MDSCs were positively related to overall survival.LOX-1+ CD15+ PMN-MDSC were elevated in HCC patients and suppressed T cell proliferation through ROS/Arg I pathway induced by ER stress. They presented positive association with the prognosis of HCC patients. This article is protected by copyright. All rights reserved.",
        "keywords": [
            "Endoplasmic reticulum stress",
            "Lectin-type oxidized LDL receptor-1",
            "hepatocelluar carcinoma patients",
            "polymorphonuclear myeloid-derived suppressor cell",
            "prognosis"
        ],
        "authors": [
            {
                "name": "Jiang Nan",
                "org": "Department of Hepatic Surgery, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Yan-Fang Xing",
                "org": "Department of Nephrology, The Third Affiliated Hospital of Guangzhou Medical University, 63 Duobao Road, Guangzhou, 510150, People's Republic of China."
            },
            {
                "name": "Bo Hu",
                "org": "Department of Central Laboratory, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Jian-Xin Tang",
                "org": "Department of Hepatic Surgery, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Hui-Min Dong",
                "org": "Department of Central Laboratory, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Yu-Mei He",
                "org": "Institute of Human Virology, Zhongshan School of Medicine Sun Yat-Sen University, 74 Zhongshan 2nd Road, Guangzhou, 510080, People's Republic of China."
            },
            {
                "name": "Dan-Yun Ruan",
                "org": "Department of Medical Oncology and Guangdong Key laboratory of Liver Disease Research, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Qing-Jian Ye",
                "org": "Department of Gynaecology, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Jia-Rong Cai",
                "org": "Department of Urology, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Xiao-Kun Ma",
                "org": "Department of Medical Oncology and Guangdong Key laboratory of Liver Disease Research, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Medical Oncology and Guangdong Key laboratory of Liver Disease Research, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Xiu-Rong Cai",
                "org": "Department of Medical Oncology and Guangdong Key laboratory of Liver Disease Research, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Ze-Xiao Lin",
                "org": "Department of Medical Oncology and Guangdong Key laboratory of Liver Disease Research, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Xiang-Yuan Wu",
                "org": "Department of Liver Surgery and Guangdong Key laboratory of Liver Disease Research, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Xing Li",
                "org": "Department of Liver Surgery and Guangdong Key laboratory of Liver Disease Research, the Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            }
        ],
        "venue": "Immunology",
        "year": 2017
    },
    "f3XDVhcU": {
        "id": "f3XDVhcU",
        "title": "Identification of the prognostic value of lymphocyte-to-monocyte ratio in patients with HBV-associated advanced hepatocellular carcinoma.",
        "abstract": "The inflammatory microenvironment serves an important function in the progression of hepatocellular carcinoma (HCC). Peripheral blood lymphocyte-to-monocyte ratio (LMR), as a novel inflammatory biomarker combining an estimate of host immune homeostasis with the tumor microenvironment, has been identified to be a predictor of clinical outcomes in a number of malignancies. The present study aimed at investigating the prognostic value of LMR in patients with hepatitis B virus (HBV)-associated advanced HCC. A total of 174 patients with HBV-associated advanced HCC, without fever or signs of infections, were analyzed. Clinicopathological parameters, including LMR, were evaluated to identify predictors of overall survival time. Univariate and multivariate analysis was performed using Cox's proportional hazards model. A threshold value was determined using a time-dependent receiver operating characteristic curve. Univariate and multivariate analysis identified LMR as an independent prognostic factor in overall survival (OS) time in patients with HBV-associated advanced HCC (P<0.05). The threshold value of LMR was 2.22. All patients were divided into either a low LMR group (\u22642.22) or a high LMR group (>2.22). The OS time of the high LMR group was significantly longer compared with the low LMR group (P<0.001). Patients in the high LMR group exhibited a significantly increased 3-month and 6-month OS rate, compared with that of the patients within the low LMR group (P<0.001). An increased level of LMR was significantly associated with the presence of metastasis, ascites and increased tumor size (P<0.01). LMR is an independent prognostic factor of HBV-associated advanced HCC patients and an increased baseline LMR level indicates an improved prognosis.",
        "keywords": [
            "advanced hepatocellular carcinoma",
            "chronic hepatitis B virus infection",
            "inflammation",
            "lymphocyte-to-monocyte ratio",
            "prognosis"
        ],
        "authors": [
            {
                "name": "Ying-Fen Hong",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Giangdong 510630, P.R. China."
            },
            {
                "name": "Zhan-Hong Chen",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Giangdong 510630, P.R. China."
            },
            {
                "name": "Li Wei",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Giangdong 510630, P.R. China."
            },
            {
                "name": "Xiao-Kun Ma",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Giangdong 510630, P.R. China."
            },
            {
                "name": "Xing Li",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Giangdong 510630, P.R. China."
            },
            {
                "name": "Jing-Yun Wen",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Giangdong 510630, P.R. China."
            },
            {
                "name": "Tian-Tian Wang",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Giangdong 510630, P.R. China."
            },
            {
                "name": "Xiu-Rong Cai",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Giangdong 510630, P.R. China."
            },
            {
                "name": "Dong-Hao Wu",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Giangdong 510630, P.R. China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Giangdong 510630, P.R. China."
            },
            {
                "name": "Dan-Yun Ruan",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Giangdong 510630, P.R. China."
            },
            {
                "name": "Ze-Xiao Lin",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Giangdong 510630, P.R. China."
            },
            {
                "name": "Qu Lin",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Giangdong 510630, P.R. China."
            },
            {
                "name": "Min Dong",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Giangdong 510630, P.R. China."
            },
            {
                "name": "Xiang-Yuan Wu",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Giangdong 510630, P.R. China."
            }
        ],
        "venue": "Oncology letters",
        "year": 2017
    },
    "UtvO9Zmj": {
        "id": "UtvO9Zmj",
        "title": "Prognosis value of mitotic kinase Aurora-A for primary duodenal adenocarcinoma.",
        "abstract": "Others and we have demonstrated that hypoxia-inducible factor 1\u03b1 (HIF-1\u03b1) and transcriptionally upregulated Aurora-A are required for disease progression in several tumors. We investigated the clinicopathological value of HIF-1\u03b1 and Aurora-A in primary duodenal adenocarcinoma (PDA). Using immunohistochemistry, we evaluated Aurora-A and HIF-1\u03b1 expression semiquantitatively in 140 PDA cases. There were 76 cases from one institute that formed the training set; 64 cases from another two institutes were used as the testing set to validate the prognostic value of Aurora-A and HIF-1\u03b1 expression. Aurora-A expression was high or sufficient in the tumor zone, whereas expression was low in the adjacent normal epithelia. High Aurora-A expression, identified using the training set receiver operator characteristic (ROC) analysis-generated cutoff score, predicted poorer overall survival both in the testing set (18.0 vs. 45.1 %, P\u2009=\u20090.001) and training set (23.1 vs. 53.9 %, P\u2009=\u20090.011). Multivariate Cox regression confirmed that Aurora-A was an independent prognostic factor. Contrary to previous studies, we did not detect any correlation between Aurora-A and HIF-1\u03b1. Survival analysis showed that HIF-1\u03b1 level was not correlated with patient outcome (P\u2009=\u20090.466). Activation of Aurora-A, an independent negative prognostic biomarker, might be used to identify particular PDA patients for more selective therapy.",
        "keywords": [
            "Primary duodenal adenocarcinoma",
            " Aurora-A",
            " HIF-1\u03b1",
            " Adjuvant chemotherapy",
            " Chemosensitivity"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China."
            },
            {
                "name": "Qu Lin",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Jing-Yun Wen",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Xing Li",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Xiao-Kun Ma",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Xin-Juan Fan",
                "org": "Department of Pathology, Gastrointestinal Institute,The Sixth Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Qin-Hua Cao",
                "org": "Department of Pathology,The First Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Min Dong",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Li Wei",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Zhan-Hong Chen",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Xiao-Yun Li",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Tian-Tian Wang",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Quentin Liu",
                "org": "State Key Laboratory of Oncology in Southern China,Sun Yat-sen University Cancer Center,Guangzhou,China"
            },
            {
                "name": "Xiang-Bo Wan",
                "org": "Department of Radiotherapy, Gastrointestinal Institute,The Sixth Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Yan-Fang Xing",
                "org": "Department of Nephrology,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou,China"
            },
            {
                "name": "Xiang-Yuan Wu",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            }
        ],
        "venue": "Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine",
        "year": 2014
    },
    "zXKSpeAL": {
        "id": "zXKSpeAL",
        "title": "Noninvasive imaging of hepatocellular carcinoma: From diagnosis to prognosis",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Hanyu Jiang",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Chunchao Xia",
                "org": ""
            },
            {
                "name": "Likun Cao",
                "org": ""
            },
            {
                "name": "Ting Duan",
                "org": ""
            },
            {
                "name": "Bin Song",
                "org": ""
            }
        ],
        "venue": "World Journal of Gastroenterology",
        "year": 2018
    },
    "W2CPfc62": {
        "id": "W2CPfc62",
        "title": "Advance directives: cancer patients' preferences and family-based decision making.",
        "abstract": "Advance directives were not widely accepted among Chinese cancer patients unless anti-cancer therapy was terminated. Most cancer patients were excluded from the discussion of an advance directive.",
        "keywords": [
            "advance directive",
            "cancer",
            "medical decision making",
            "patients\u2019 preference"
        ],
        "authors": [
            {
                "name": "Yan-Fang Xing",
                "org": "Department of Nephrology, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, People's Republic of China."
            },
            {
                "name": "Jin-Xiang Lin",
                "org": "Department of Medical Oncology, Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, People's Republic of China."
            },
            {
                "name": "Xing Li",
                "org": "Department of Medical Oncology, Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, People's Republic of China."
            },
            {
                "name": "Qu Lin",
                "org": "Department of Medical Oncology, Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, People's Republic of China."
            },
            {
                "name": "Xiao-Kun Ma",
                "org": "Department of Medical Oncology, Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, People's Republic of China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Medical Oncology, Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, People's Republic of China."
            },
            {
                "name": "Dong-Hao Wu",
                "org": "Department of Medical Oncology, Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, People's Republic of China."
            },
            {
                "name": "Li Wei",
                "org": "Department of Medical Oncology, Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, People's Republic of China."
            },
            {
                "name": "Liang-Hong Yin",
                "org": "School of Medicine, Jinan University, Guangzhou 510632, People's Republic of China."
            },
            {
                "name": "Xiang-Yuan Wu",
                "org": "Department of Medical Oncology, Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, People's Republic of China."
            }
        ],
        "venue": "Oncotarget",
        "year": 2017
    },
    "ws5VTTtc": {
        "id": "ws5VTTtc",
        "title": "Feasibility of endoscopic submucosal dissection for upper gastrointestinal submucosal tumors treatment and value of endoscopic ultrasonography in pre-operation assess and post-operation follow-up: a prospective study of 224 cases in a single medical center.",
        "abstract": "Diagram, diagnosis, and treatment with endoscopic submucosal dissection (ESD) for upper gastrointestinal submucosal tumors (SMTs) remain controversial, although endoscopic ultrasonography (EUS) and ESD have been established in diagnosis and treatment of SMTs in decades, respectively. In this study, we have investigated prospectively the profile of upper gastrointestinal SMTs, assessed the effect and feasibility of ESD in upper gastrointestinal SMTs treatment, as well as value of EUS in pre-ESD diagnosis and post-ESD follow-up for gastrointestinal SMTs.The upper gastrointestinal SMTs patients detected with endoscopy were further checked by EUS, then received series ESD treatment, and fulfilled 3- and 12-month follow-up EUS detection between July 2011 and March 2015. The parameters of SMTs with EUS examination (size, original layer) and treatment with ESD (en bloc resection rate, procedure time, procedure-related complications) were investigated and analyzed.A total number of 224 patients with upper gastrointestinal SMTs were enrolled, and 108 (48.2 %) were men. The mean age was 50.4 \u00b1 12.0 years (range 19-77 years). In total, 92 (41.1 %), 14 (6.3 %), 61 (27.2 %), 22 (9.8 %), 25 (11.2 %), and 10 (4.5 %) SMTs were located in esophagus, cardiac, fundus, body and antrum of stomach, duodenum, respectively. Two hundred and eight (92.9 %) patients were successfully treated with an en bloc ESD, while other 16 patients (7.1 %) suffered ESD failure (5.3 %, 12 case) or severe complications (1.8 %, 4 cases). The mean procedure time of ESD was 47.4 \u00b1 27.3 min (range 10-180 min). The mean size of the SMTs measured with ESD samples was 13.6 \u00b1 9.5 mm (range 4-113 mm). In total, 87 (38.8 %), 23 (10.3 %), and 114 (50.9 %) tumors originated from muscularis mucosa, submucosa, and muscularis propria, respectively. The majority of SMTs were leiomyoma (109, 48.7 %) and gastrointestinal stromal tumors (GIST) (77, 34.4 %), while other SMTs were confirmed as ectopic pancreas (21, 9.4 %), adenoid tumor (8, 3.6 %), lipoma (5, 2.2 %), neuroendocrine tumor (3, 1.3 %), and granulosa cell tumor (1, 0.4 %). The accuracy rate of EUS in pathological diagnosis or original layer was 82.6 % (185/224) or 74.6 % (167/224). Residual tumors were detected with EUS in 3 patients (1.3 %) in 3-month follow-up and no recurrence during 12-month follow-up period.The predominant SMTs in upper gastrointestinal tract were leiomyoma in esophageal tumors which originated from muscularis mucosae and GIST in stomach which originated from muscularis propria detected satisfactorily with EUS. This study showed that ESD was a safe and effective treatment for upper gastrointestinal SMTs.",
        "keywords": [
            "Endoscopic",
            "Submucosal tumor",
            "Ultrasonography",
            "Efficacy"
        ],
        "authors": [
            {
                "name": "Ganqing He",
                "org": "Department of Endoscopy Center, Gastroenterology and Hepatology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China."
            },
            {
                "name": "Jinhui Wang",
                "org": "Department of Endoscopy Center, Gastroenterology and Hepatology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China."
            },
            {
                "name": "Baili Chen",
                "org": "Department of Endoscopy Center, Gastroenterology and Hepatology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China."
            },
            {
                "name": "Xiangbin Xing",
                "org": "Department of Endoscopy Center, Gastroenterology and Hepatology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China."
            },
            {
                "name": "Jinping Wang",
                "org": "Department of Endoscopy Center, Gastroenterology and Hepatology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Endoscopy Center, Gastroenterology and Hepatology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China."
            },
            {
                "name": "Yao He",
                "org": "Department of Endoscopy Center, Gastroenterology and Hepatology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China."
            },
            {
                "name": "Yi Cui",
                "org": "Department of Endoscopy Center, Gastroenterology and Hepatology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China."
            },
            {
                "name": "Minhu Chen",
                "org": "Department of Endoscopy Center, Gastroenterology and Hepatology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China. minhuch@yeah.net."
            }
        ],
        "venue": "Surgical endoscopy",
        "year": 2016
    },
    "EunXpYDO": {
        "id": "EunXpYDO",
        "title": "Expression of microtubule- associated protein 2 correlates with better prognosis of pancreatic neuroendocrine tumors",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Tiantian Song",
                "org": "Peking Union Medical College"
            },
            {
                "name": "Yu Xiao",
                "org": "Peking Union Medical College"
            },
            {
                "name": "Chunmei Bai",
                "org": "Peking Union Medical College"
            },
            {
                "name": "Naishi Li",
                "org": "Peking Union Medical College"
            },
            {
                "name": "Jie Chen",
                "org": "Sun Yat-Sen University"
            },
            {
                "name": "Dachun Zhao",
                "org": "Peking Union Medical College"
            },
            {
                "name": "Yuli Song",
                "org": "Peking Union Medical College"
            },
            {
                "name": "Kaizhou Jin",
                "org": "Fudan University Shanghai Cancer Center"
            },
            {
                "name": "Liming Zhu",
                "org": "Peking Union Medical College"
            },
            {
                "name": "Run Yu",
                "org": "University of California at Los Angeles"
            },
            {
                "name": "Xianjun Yu",
                "org": "Pancreas & Hepatobiliary Surgery"
            },
            {
                "name": "Yuanjia Chen",
                "org": "Peking Union Medical College"
            }
        ],
        "venue": "Clinical Oncology and Cancer Research",
        "year": 2017
    },
    "mAeokfok": {
        "id": "mAeokfok",
        "title": "Clinicopathological features and outcome for neuroendocrine neoplasms of gastroesophageal junction: A population-based study.",
        "abstract": "GEJ-NENs were mostly poorly differentiated carcinomas, and all of Chinese patients were NEC/MANEC. The outcome of MANEC was preferable to NECs. Both lymph nodes metastasis and distant disease were independent predictors of prognosis. Surgical resection can improve survival, but postoperative adjuvant therapy had no additional benefit. GEJ-NENs have worse survival than other gastric NENs.",
        "keywords": [
            "SEER",
            "clinicopathological characteristics",
            "gastric",
            "gastroesophageal junction",
            "neuroendocrine neoplasm"
        ],
        "authors": [
            {
                "name": "Panpan Zhang",
                "org": "Beijing Cancer Hospital, Peking University Cancer Hospital & Institute, Beijing, China."
            },
            {
                "name": "Wei Wang",
                "org": "Sun Yat-sen University Cancer Center, Guangzhou, China."
            },
            {
                "name": "Ming Lu",
                "org": "Beijing Cancer Hospital, Peking University Cancer Hospital & Institute, Beijing, China."
            },
            {
                "name": "Changqing Zeng",
                "org": "Fujian Province Hospital, Fujian, China."
            },
            {
                "name": "Jie Chen",
                "org": "The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China."
            },
            {
                "name": "Enxiao Li",
                "org": "The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China."
            },
            {
                "name": "Huangying Tan",
                "org": "China-Japan Friendship Hospital, Beijing, China."
            },
            {
                "name": "Wei Wang",
                "org": "Huadong Hospital, Shanghai, China."
            },
            {
                "name": "Xianjun Yu",
                "org": "Fudan University Shanghai Cancer Center, Shanghai, China."
            },
            {
                "name": "Qiyun Tang",
                "org": "Jiangsu Province Hospital, Jiangsu, China."
            },
            {
                "name": "Jiemin Zhao",
                "org": "The First Hospital of Changzhou, Jiangsu, China."
            },
            {
                "name": "Lin Shen",
                "org": "Beijing Cancer Hospital, Peking University Cancer Hospital & Institute, Beijing, China."
            },
            {
                "name": "Jie Li",
                "org": "Beijing Cancer Hospital, Peking University Cancer Hospital & Institute, Beijing, China."
            }
        ],
        "venue": "Cancer medicine",
        "year": 2018
    },
    "ZPQ1Yld8": {
        "id": "ZPQ1Yld8",
        "title": "Neutrophil-to-lymphocyte ratio acts as a prognostic factor for patients with advanced hepatocellular carcinoma.",
        "abstract": "Few studies investigated the prognosis of patients with advanced hepatocellular carcinoma (aHCC). This study was aimed to determine the prognostic value of differential blood cell counts including blood white cells, neutrophil, lymphocyte, neutrophil-lymphocyte ratio (NLR), and platelet in patients with aHCC. A total of 205 ethnic Chinese aHCC patients receiving non-systematic sorafenib were analyzed retrospectively. The prognostic value of differential blood cell counts and NLR for overall survival (OS) was determined by integration into Cancer of the Liver Italian Program (CLIP) score system using backward elimination model of multivariate Cox regression. As a result, NLR was confirmed to be an independent predictor for OS (p = 0.001) with the rest parameters presented negative results. Then, aHCC patients were dichotomized into two groups according to NLR values \u2264 2.43 or >2.43. Patients with low NLR presented lower CLIP score and higher 6-month survival rate (56.1 vs 25.9%) compared with patients with high NLR level. Besides, low NLR level was associated with favorable prognostic factors such as lower \u03b1-fetoprotein, alkaline phosphatase, and total bilirubin, as well as decreased incidence of ascites, portal vein thrombosis, and metastasis. Besides, low NLR level was associated less white cells and neutrophil granulocytes, as well as more lymphocyte. In summary, the present study firstly indentified NLR as an independent prognostic factor in aHCC patients receiving no systematic sorafenib.",
        "keywords": [
            "Neutrophil-lymphocyte ratio",
            " Hepatocellular carcinoma",
            " Prognosis",
            " Blood cell counts",
            " Score system"
        ],
        "authors": [
            {
                "name": "Xing Li",
                "org": "Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Zhan-Hong Chen",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,People\u2019s Republic of China"
            },
            {
                "name": "Xiao-Kun Ma",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,People\u2019s Republic of China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,People\u2019s Republic of China"
            },
            {
                "name": "Dong-Hao Wu",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,People\u2019s Republic of China"
            },
            {
                "name": "Qu Lin",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,People\u2019s Republic of China"
            },
            {
                "name": "Min Dong",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,People\u2019s Republic of China"
            },
            {
                "name": "Li Wei",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,People\u2019s Republic of China"
            },
            {
                "name": "Tian-Tian Wang",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,People\u2019s Republic of China"
            },
            {
                "name": "Dan-Yun Ruan",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,People\u2019s Republic of China"
            },
            {
                "name": "Ze-Xiao Lin",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,People\u2019s Republic of China"
            },
            {
                "name": "Yan-Fang Xing",
                "org": "Department of Medical Oncology,Shenzhen People\u2019s Hospital,Shenzhen,People\u2019s Republic of China"
            },
            {
                "name": "Yun Deng",
                "org": "Department of Medical Oncology,Shenzhen People\u2019s Hospital,Shenzhen,People\u2019s Republic of China"
            },
            {
                "name": "Xiang-Yuan Wu",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,People\u2019s Republic of China"
            },
            {
                "name": "Jin-Yun Wen",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,People\u2019s Republic of China"
            }
        ],
        "venue": "Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine",
        "year": 2014
    },
    "THNgYgSd": {
        "id": "THNgYgSd",
        "title": "Local regional therapy before liver transplantation for hepatocellular carcinoma",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Nan Jiang",
                "org": "Department of Transplantation the Second Affiliated Hospital of Southern Universtiy of Science and Technology 29th Bulan Road Shenzhen 510623People's Republic of China"
            },
            {
                "name": "Xing Li",
                "org": "Department of Medical Oncology the Third Affiliated Hospital of Sun Yat\u2010sen University 600 Tianhe Road Guangzhou 510630People's Republic of China"
            },
            {
                "name": "Yan\u2010Fang Xing",
                "org": "Department of Nephrology the Third Affiliated Hospital of Guangzhou Medical University 63 Duobao Road Guangzhou 510150 People's Republic of China"
            },
            {
                "name": "Yi\u2010Dan Qiao",
                "org": "Department of Medical Oncology the Third Affiliated Hospital of Sun Yat\u2010sen University 600 Tianhe Road Guangzhou 510630People's Republic of China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Medical Oncology the Third Affiliated Hospital of Sun Yat\u2010sen University 600 Tianhe Road Guangzhou 510630People's Republic of China"
            }
        ],
        "venue": "Hepatology",
        "year": 2019
    },
    "BdRxOz4h": {
        "id": "BdRxOz4h",
        "title": "Pancreatic acinar cell carcinoma developed in the pancreatic head after distal pancreatectomyfor chronicpancreatitis",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Anan Liu",
                "org": ""
            },
            {
                "name": "Jun Chen",
                "org": ""
            },
            {
                "name": "L.G. Shi",
                "org": ""
            },
            {
                "name": "D.L. Chen",
                "org": ""
            },
            {
                "name": "L. Tang",
                "org": ""
            },
            {
                "name": "Chenghao Shao",
                "org": ""
            }
        ],
        "venue": "Pancreatology",
        "year": 2016
    },
    "N96j7XmV": {
        "id": "N96j7XmV",
        "title": "Efficacy and tolerance of pegaspargase-based chemotherapy in patients with nasal-type extranodal NK/T-cell lymphoma: a pilot study.",
        "abstract": "Nasal-type extranodal natural killer (NK)/T-cell lymphoma (ENKL) is a highly invasive cancer with a poor prognosis. More effective and safer treatment regimens for ENKL are needed. Pegaspargase (PEG-Asp) has a similar mechanism of action to L-asparaginase (L-Asp), but presents lower antigenicity. The aim of the present research was to evaluate the safety profile and the latent efficacy of a PEG-Asp-based treatment regimen in patients with ENKL. Data collected from 20 patients with histologically confirmed ENKL, admitted to the Third Affiliated Hospital of Sun Yat-Sen University from January 2009 to August 2013, were included in the study. All patients received 2500 IU/m2/IM PEG-Asp on day 1 of every 21-day treatment cycle. Patients received combination chemotherapy with CHOP (n=5), EPOCH (n=7), GEMOX (n=7) or CHOP with bleomycin (n=1). After 2-5 treatment cycles (median, 4 cycles) of PEG-Asp-based chemotherapy, five patients (25%) showed a complete response (CR), and the overall response rate (ORR) was 60%. Grade 3/4 neutropenia occurred in fourteen patients (70%). Grade 3 alanine aminotransferase (ALT) elevation was observed in two. Grade 1-2 non-hematological toxicity consisted of activated partial thromboplastin time (APTT) elongation (n=9), hypofibrinogenemia (n=6), hypoproteinemia (n=17), hyperglycemia (n=3), and nausea (n=6). No allergic reactions were detected. No treatment related death was reported. Our results suggested that PEG-Asp-based chemotherapy presented an acceptable tolerance and a potential short-term outcome in patients with nasal-type ENKL.",
        "keywords": [
            "response rate"
        ],
        "authors": [
            {
                "name": "Jing-Yun Wen",
                "org": "Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China E-mail : wuxiangy@mail.sysu.edu.cn."
            },
            {
                "name": "Mai Li",
                "org": ""
            },
            {
                "name": "Xing Li",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Qu Lin",
                "org": ""
            },
            {
                "name": "Xiao-kun Ma",
                "org": ""
            },
            {
                "name": "Min Dong",
                "org": ""
            },
            {
                "name": "Li Wei",
                "org": ""
            },
            {
                "name": "Zhan-Hong Chen",
                "org": ""
            },
            {
                "name": "Xiang-Yuan Wu",
                "org": ""
            }
        ],
        "venue": "Asian Pacific journal of cancer prevention : APJCP",
        "year": 2014
    },
    "xU8PbSQY": {
        "id": "xU8PbSQY",
        "title": "Modified CLIP score with albumin-bilirubin grade in relation to prognostic value in HBV-related hepatocellular carcinoma patients treated with transcatheter arterial chemoembolization therapy.",
        "abstract": "480Background: Child-Pugh grade is widely used to assess hepatic function reserve, but it is relatively subjective for assessment of hepatic encephalopathy. A newly developed scoring system combining albumin and bilirubin, called ALBI grade, aims to assess liver function objectively. In prognosis prediction of hepatocellular carcinoma (HCC), The Cancer of the Liver Italian Program (CLIP) score is commonly used in clinical practice and includes Child-Pugh evaluation. We substituted ALBI grade for Child-Pugh grade to establish ALBI-CLIP system and conducted this study to validate the prognostic value of ALBI -CLIP in HBV-related HCC patients after TACE therapy. Methods: We retrospectively analyzed HBV-related HCC patients who received TACE therapy. Baseline data were collected and evaluated. Child-Pugh grade and ALBI grade were integrated into CLIP and ALBI-CLIP systems, respectively. Univariate and multivariate analyses were conducted to identify independent prognostic factors for overall survival. Compari...",
        "keywords": "",
        "authors": [
            {
                "name": "Xiu-Rong Cai",
                "org": ""
            },
            {
                "name": "Zhan-Hong Chen",
                "org": "Sun Yat-sen University, Guangzhou, China;"
            },
            {
                "name": "Qu Lin",
                "org": "Sun Yat-sen University, Guangzhou, China;"
            },
            {
                "name": "Min Dong",
                "org": "Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;"
            },
            {
                "name": "Xiao-Kun Ma",
                "org": "Sun Yat-sen University, Guangzhou, China;"
            },
            {
                "name": "Jie Chen",
                "org": "Sun Yat-sen University, Guangzhou, China;"
            },
            {
                "name": "Jing-Yun Wen",
                "org": "Sun Yat-sen University, Guangzhou, China;"
            },
            {
                "name": "Xiang-yuan Wu",
                "org": "Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;"
            }
        ],
        "venue": "Journal of Clinical Oncology",
        "year": 2018
    },
    "sD5OJKCh": {
        "id": "sD5OJKCh",
        "title": "Sunitinib is effective and tolerable in Chinese patients with advanced pancreatic neuroendocrine tumors: a multicenter retrospective study in China.",
        "abstract": "Sunitinib had similar treatment efficacy to western patients with pNET in China. A 25\u00a0mg/day dosage was better tolerated than 37.5\u00a0mg/day in Chinese patients, and there were no significant differences in sunitinib Css between the two dosage groups. Patients with higher sunitinib Css seem to have better efficacy. Sunitinib-related hypertension may be a predictor of a better treatment effect.",
        "keywords": [
            "Neuroendocrine tumor",
            "Pancreatic",
            "Sunitinib",
            "Treatment"
        ],
        "authors": [
            {
                "name": "Yuhong Wang",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou, 510080, Guangdong, China."
            },
            {
                "name": "Kaizhou Jin",
                "org": "Department of Pancreatic Oncology, Shanghai Cancer Center, Fudan University, No. 270, Dong An Road, Shanghai, 200032, China."
            },
            {
                "name": "Huangying Tan",
                "org": "Department of Traditional Chinese Medicine Oncology, China-Japan Friendship Hospital, No. 2 Yinghua Dongjie, Hepingli, Beijing, 100029, China."
            },
            {
                "name": "Pan Zhang",
                "org": "Department of Traditional Chinese Medicine Oncology, China-Japan Friendship Hospital, No. 2 Yinghua Dongjie, Hepingli, Beijing, 100029, China."
            },
            {
                "name": "Qiuchen Yang",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou, 510080, Guangdong, China."
            },
            {
                "name": "Wei Wang",
                "org": "Department of Gastric and Pancreatic Surgery, Sun Yat-sen University Cancer Center, 651 Dongfeng East Road, Guangzhou, 510080, Guangdong, China."
            },
            {
                "name": "Jie Li",
                "org": "Department of Gastroenterological Oncology, Peking University Cancer Hospital, No. 52 Fucheng Road, Beijing, 100142, China."
            },
            {
                "name": "Chenghao Shao",
                "org": "Department of General Surgery, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200032, China."
            },
            {
                "name": "Ling Xue",
                "org": "Department of Pathology, the First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou, 510080, Guangdong, China."
            },
            {
                "name": "Shiting Feng",
                "org": "Department of Radiology, the First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou, 510080, Guangdong, China."
            },
            {
                "name": "Minhu Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou, 510080, Guangdong, China."
            },
            {
                "name": "Xianjun Yu",
                "org": "Department of Pancreatic Oncology, Shanghai Cancer Center, Fudan University, No. 270, Dong An Road, Shanghai, 200032, China. yuxianjun@fudanpci.org."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou, 510080, Guangdong, China. chen0jie@hotmail.com."
            }
        ],
        "venue": "Cancer chemotherapy and pharmacology",
        "year": 2017
    },
    "Lz2wKs4W": {
        "id": "Lz2wKs4W",
        "title": "Clinicopathologic characteristics and prognosis of gastroenteropancreatic neuroendocrine neoplasms: a multicenter study in South China.",
        "abstract": "Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are a heterogeneous group of rare tumors. Many issues in terms of epidemiologic features, pathogenesis, and treatment of GEP-NENs are still under discussion. Our study aimed to analyze the clinicopathologic characteristics and prognosis of Chinese patients with GEP-NENs.Complete clinicopathologic data and survival information of 1183 patients with GEP-NENs treated between 2005 and 2015 were collected from five medical centers in Guangdong Province, China. Patient survival was estimated using the Kaplan-Meier method and analyzed using the log-rank test; prognostic factors were analyzed using the Cox proportional hazards model.The most common tumor location was the rectum (37.4%), followed by the pancreas (28.1%), stomach (20.7%), small intestine (7.2%), appendix (3.4%), and colon (3.3%). After initial definitive diagnosis, 1016 (85.9%) patients underwent surgery. The 1-, 3-, and 5-year overall survival (OS) rates for the entire cohort were 87.9%, 78.5%, and 72.8%, respectively. The 3-year OS rates of patients with G1, G2, and G3 tumors were 93.1%, 82.7%, and 43.1%, respectively (P < 0.001). The 3-year OS rates of patients with stage I, II, III, and IV tumors were 96.0%, 87.3%, 64.0%, and 46.8%, respectively (P < 0.001). Patients with distant metastasis who underwent palliative surgery had a longer survival than those who did not (P = 0.003). Similar survival benefits of palliative surgery were observed in patients with neuroendocrine tumor (P = 0.031) or neuroendocrine carcinoma (P = 0.046). In multivariate analysis, age, grade, N category, M category, and surgery were found to be independent prognostic factors.Patients with GEP-NENs who are women, younger than 50 years old, have smaller tumor size, have lower tumor grade, have lower T/N/M category, and who undergo surgery can have potentially longer survival time. Our data showed that surgery can improve the prognosis of GEP-NEN patients with distant metastasis. However, randomized controlled trials need to be conducted to establish the optimal criteria for selecting patients to undergo surgery.",
        "keywords": [
            "China",
            "Gastroenteropancreatic neuroendocrine neoplasms",
            "Prognosis",
            "Surgery"
        ],
        "authors": [
            {
                "name": "Cheng Fang",
                "org": "Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou, 510060, Guangdong, P. R. China."
            },
            {
                "name": "Wei Wang",
                "org": "Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou, 510060, Guangdong, P. R. China."
            },
            {
                "name": "Yu Zhang",
                "org": "Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, Guangdong, P. R. China."
            },
            {
                "name": "Xingyu Feng",
                "org": "Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Science, Guangzhou, 510080, Guangdong, P. R. China."
            },
            {
                "name": "Jian Sun",
                "org": "Department of Biliopancreatic Surgery, The Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, 510120, Guangdong, P. R. China."
            },
            {
                "name": "Yujie Zeng",
                "org": "Department of Gastrointestinal Surgery, The Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 510120, Guangdong, P. R. China."
            },
            {
                "name": "Ye Chen",
                "org": "Department of Gastroenterology, Nanfang Hospital of Southern Medical University, Guangdong Provincial Key Laboratory of Gastroenterology, Guangzhou, 510515, Guangdong, P. R. China. yechen@smu.edu.cn."
            },
            {
                "name": "Yong Li",
                "org": "Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Science, Guangzhou, 510080, Guangdong, P. R. China. yuan821007@126.com."
            },
            {
                "name": "Minhu Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, Guangdong, P. R. China."
            },
            {
                "name": "Zhiwei Zhou",
                "org": "Department of Gastric Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou, 510060, Guangdong, P. R. China. zhouzhw@sysucc.org.cn."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, Guangdong, P. R. China. chen0jie@hotmail.com."
            }
        ],
        "venue": "Chinese journal of cancer",
        "year": 2017
    },
    "RZi7yl2e": {
        "id": "RZi7yl2e",
        "title": "[Prognostic value of carcinoembryonic antigen, alpha fetoprotein, carbohydrate antigen 125 and carbohydrate antigen 19-9 in gastroenteropancreatic neuroendocrine neoplasms].",
        "abstract": "Elevation of AFP, CEA, CA125 or CA19-9 is not common in GEP-NEN. Patients with elevation of these biomarkers have poor survival.",
        "keywords": "",
        "authors": [
            {
                "name": "Luohai Chen",
                "org": ""
            },
            {
                "name": "Yu Zhang",
                "org": ""
            },
            {
                "name": "Minhu Chen",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. chen0jie@hotmail.com."
            }
        ],
        "venue": "Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery",
        "year": 2017
    },
    "fxtAUXyl": {
        "id": "fxtAUXyl",
        "title": "Exploration of the Exact Prognostic Significance of Lymphatic Metastasis in Jejunoileal Neuroendocrine Tumors.",
        "abstract": "The current definition of lymphatic metastasis could not help predict patient survival. Our newly proposed classification of lymphatic metastasis is better than the ENETS and AJCC 8th edition staging classifications in evaluating the prognostic significance of lymphatic metastasis in SBNETs. Systematic resection of lymph nodes (\u2265\u200912) could help improve patient survival.",
        "keywords": "",
        "authors": [
            {
                "name": "Luohai Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China."
            },
            {
                "name": "Yunda Song",
                "org": "Department of Hepatobiliary and Pancreatic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China."
            },
            {
                "name": "Yu Zhang",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China."
            },
            {
                "name": "Minhu Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. chenminhu@mail.sysu.edu.cn."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. chen0jie@hotmail.com."
            }
        ],
        "venue": "Annals of surgical oncology",
        "year": 2018
    },
    "CW8N55Rt": {
        "id": "CW8N55Rt",
        "title": "Gastrokine-2 suppresses epithelial mesenchymal transition through PI3K/AKT/GSK3\u03b2 signaling in gastric cancer.",
        "abstract": "Epithelial-mesenchymal transition (EMT) plays an important role in metastasis of gastric cancer. Our previous study showed that Gastrokine-2 (GKN2) can inhibit the metastasis of SGC-7901 and AGS cells. Herein, we further explored the role of GKN2 in epithelial mesenchymal transition of gastric cancer cells and the underlying mechanisms. We found that overexpression of GKN2 can lower the protein expression level of Snail and markedly elevate E-cadherin protein level in SGC7901 and AGS cells. Further data showed that knockdown of snail can inhibit the migration and invasion of SGC-7901 and AGS cells. It is known that Snail can be phosphorylated by GSK3\u03b2, a downstream protein of PI3K/AKT pathway. We then test protein expression of p-GSK3\u03b2(Ser-9), the downstream protein of PI3K/AKT, which was significantly decreased under the circumstance of GKN2 overexpression. Moreover, LY294002, a PI3K inhibitor, can reverse the protein expression change of E-cadherin and snail induced by siGKN2. Taken together, these findings suggested that GKN2 suppressed epithelial mesenchymal transition of gastric cancer cells by downregulation of snail through PI3K/AKT/GSK3\u03b2 signaling pathway.",
        "keywords": [
            "Epithelial mesenchymal transition",
            "Gastric cancer",
            "Gastrokine-2",
            "Metastasis"
        ],
        "authors": [
            {
                "name": "Jin Dai",
                "org": "Division of Gastroenterology, Guizhou Provincial People's Hospital, Guiyang, Guizhou, 550002, China."
            },
            {
                "name": "Chenchen Qian",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan II road, Guangzhou, Guangdong, 510080, China."
            },
            {
                "name": "Mingli Su",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan II road, Guangzhou, Guangdong, 510080, China."
            },
            {
                "name": "Minhu Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan II road, Guangzhou, Guangdong, 510080, China. chenminhu@vip.163.com."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan II road, Guangzhou, Guangdong, 510080, China. chen0jie@hotmail.com."
            }
        ],
        "venue": "Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine",
        "year": 2016
    },
    "jtEN0hYY": {
        "id": "jtEN0hYY",
        "title": "CT evaluation of response in advanced gastroenteropancreatic neuroendocrine tumors treated with long-acting-repeatable octreotide: what is the optimal size variation threshold?",
        "abstract": "\u2022 Octreotide LAR can significantly prolong PFS among patients with well-differentiated advanced GEP-NETs. \u2022 No optimal tumor size-based response criteria are reported in GEP-NETs with octreotide. \u2022 Ten percent tumor shrinkage is a reliable indicator of the response to octreotide for advanced GEP-NETs.",
        "keywords": [
            "Neuroendocrine tumors",
            "Octreotide",
            "Progression-free survival",
            "Response Evaluation Criteria in Solid Tumors",
            "Tomography",
            "spiral computed"
        ],
        "authors": [
            {
                "name": "Yanji Luo",
                "org": "Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58th, The Second Zhongshan Road, Guangzhou, 510080, Guangdong, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, 58th, The Second Zhongshan Road, Guangzhou, 510080, Guangdong, China."
            },
            {
                "name": "Bingqi Shen",
                "org": "Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58th, The Second Zhongshan Road, Guangzhou, 510080, Guangdong, China."
            },
            {
                "name": "Meng Wang",
                "org": "Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58th, The Second Zhongshan Road, Guangzhou, 510080, Guangdong, China."
            },
            {
                "name": "Huasong Cai",
                "org": "Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58th, The Second Zhongshan Road, Guangzhou, 510080, Guangdong, China."
            },
            {
                "name": "Ling Xu",
                "org": "Faculty of Medicine and Dentistry, University of Western Australia, Perth, 6009, Australia."
            },
            {
                "name": "Luohai Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, 58th, The Second Zhongshan Road, Guangzhou, 510080, Guangdong, China."
            },
            {
                "name": "Minhu Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, 58th, The Second Zhongshan Road, Guangzhou, 510080, Guangdong, China."
            },
            {
                "name": "Zi-Ping Li",
                "org": "Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58th, The Second Zhongshan Road, Guangzhou, 510080, Guangdong, China. liziping163@163.com."
            },
            {
                "name": "Shi-Ting Feng",
                "org": "Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58th, The Second Zhongshan Road, Guangzhou, 510080, Guangdong, China. fst1977@163.com."
            }
        ],
        "venue": "European radiology",
        "year": 2018
    },
    "mky0fP82": {
        "id": "mky0fP82",
        "title": "Expression of somatostatin receptors in gastroenteropancreatic neuroendocrine neoplasm and retrospective clinical study of octreotide LAR in the treatment of advanced GEP-NET",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yuhong Wang",
                "org": "Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"
            },
            {
                "name": "Wei Wang",
                "org": "Department of Gastric and Pancreatic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China"
            },
            {
                "name": "Cheng Fang",
                "org": "Department of Gastric and Pancreatic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China"
            },
            {
                "name": "Zhi Wei Zhou",
                "org": ""
            },
            {
                "name": "Minhu Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Pancreatology",
        "year": 2016
    },
    "Xlzr1w9P": {
        "id": "Xlzr1w9P",
        "title": "Quantitative Pretreatment CT Parameters as Predictors of Tumor Response of NET Liver Metastasis to TAE",
        "abstract": "AEI and PEI, parameters from evaluation of CT pre-treatment attenuation of NETLMs, could predict response to TAE treatment.",
        "keywords": "",
        "authors": [
            {
                "name": "Yiming Liu",
                "org": ""
            },
            {
                "name": "Wenchuan Chen",
                "org": ""
            },
            {
                "name": "Wei Cui",
                "org": ""
            },
            {
                "name": "Haikuan Liu",
                "org": ""
            },
            {
                "name": "Xiangfei Zhou",
                "org": ""
            },
            {
                "name": "Luohai Chen",
                "org": ""
            },
            {
                "name": "Jiaping Li",
                "org": ""
            },
            {
                "name": "Minhu Chen",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Yu Wang",
                "org": ""
            }
        ],
        "venue": "Neuroendocrinology",
        "year": 2019
    },
    "7TPONQOF": {
        "id": "7TPONQOF",
        "title": "Use of the mitotic kinase aurora-A activation to predict outcome for primary duodenal adenocarcinoma.",
        "abstract": "4131 Background: We and others had proved that hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1) and transcriptionally upregulated Aurora-A were required for disease progression in several tumors. Methods: We addressed the clinicopathologic value of HIF-1\u03b1 and Aurora-a in primary duodenal adenocarcinoma (PDA). Aurora-a and HIF-1\u03b1 expression were semi-quantitative evaluated by immunohistochemistry in 140 PDA. Among which, 76 patients from one institute acted as training set, and 64 cases from another two institutes were used as testing set to validate the prognostic effect of Aurora-a and HIF-1\u03b1. Results: We found that Aurora-a was high or sufficient expressed in tumor zone, whereas low-expressed in the normal adjacent epithelia. Moreover, Aurora-a high expression, classified by training set ROC analysis-generated cutoff score, predicted an inferior overall survival both in testing set and training set. Multivariate Cox regression confirmed that Aurora-a was indeed an independent prognostic factor (Table). Contrary to ...",
        "keywords": "",
        "authors": [
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Jing-Yun Wen",
                "org": ""
            },
            {
                "name": "Zhan-Hong Chen",
                "org": ""
            },
            {
                "name": "Qu Lin",
                "org": ""
            },
            {
                "name": "Xiao-Kun Ma",
                "org": ""
            },
            {
                "name": "Li Wei",
                "org": ""
            },
            {
                "name": "Xing Li",
                "org": ""
            },
            {
                "name": "Tian\u2011Tian Wang",
                "org": ""
            },
            {
                "name": "Dan-Yun Ruan",
                "org": ""
            },
            {
                "name": "Ze-Xiao Lin",
                "org": ""
            },
            {
                "name": "Xiang-Bo Wan",
                "org": ""
            },
            {
                "name": "Quentin Liu",
                "org": ""
            },
            {
                "name": "Xiang-yuan Wu",
                "org": ""
            }
        ],
        "venue": "Journal of Clinical Oncology",
        "year": 2017
    },
    "vGERIoey": {
        "id": "vGERIoey",
        "title": "Surgery management for sporadic small (\u22642 cm), non-functioning pancreatic neuroendocrine tumors: a consensus statement by the Chinese Study Group for Neuroendocrine Tumors (CSNET).",
        "abstract": "The incidence of small (\u22642\u00a0cm), non-functioning pancreatic neuroendocrine tumors (NF-pNETs) increased in the last decades. Before making appropriate strategy for patients with NF-pNETs \u22642\u00a0cm, pathological confirmation is vital. Incidentally diagnosed, sporadic small NF-pNETs may bring aggressive behavior and poor prognosis, such as extrapancreatic extension, lymph nodal metastasis, distant metastasis and recurrence, even causing disease-related death. Understanding and formulating an appropriate strategy for the patients with sporadic small, non-functioning pancreatic neuroendocrine tumors have been controversial for some time. Although several studies have reported that patients with NF-pNETs \u22642\u00a0cm had less rate of malignant behavior compared with larger ones (>2 cm); and the surgery approach may leading to surgery-related pancreatic complications; but there is still a lack of level\u00a0I evidence to convince surgeons to abandon all cases with sporadic small NF-pNETs. Based on an updated literature search and review, the members of the Chinese Study Group for Neuroendocrine Tumors (CSNET) from high-volume centers have reached a consensus on the issue of the management strategy for the sporadic small NF-pNETs. We recommend that, except for some selected patients with NF-pNETs <1\u00a0cm, incidentally discovered and unacceptable surgical risks, all others with NF-pNETs \u22642\u00a0cm should undergo tumor resection with lymph node dissection or at least lymph node sampling and careful postoperative surveillance.",
        "keywords": "",
        "authors": [
            {
                "name": "Guang Yang",
                "org": "Department of General Surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, P.R. China."
            },
            {
                "name": "Meng Ji",
                "org": "Department of General Surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, P.R. China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P.R. China."
            },
            {
                "name": "Rufu Chen",
                "org": "Department of Hepatopancreatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P.R. China."
            },
            {
                "name": "Ye Chen",
                "org": "Department of Gastroenterology, Nanfang Hospial, Southern Medical University, Guangzhou, Guangdong, P.R. China."
            },
            {
                "name": "Deliang Fu",
                "org": "Department of Pancreatic Surgery, Pancreatic Disease Institute, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, P.R. China."
            },
            {
                "name": "Baohua Hou",
                "org": "Department of General Surgery, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, P.R. China."
            },
            {
                "name": "Heguang Huang",
                "org": "Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, P.R. China."
            },
            {
                "name": "Liming Jiang",
                "org": "Department of Radiology, Cancer Hospital/Institute, Chinese Academy of Medical Sciences, Beijing, P.R. China."
            },
            {
                "name": "Kaizhou Jin",
                "org": "Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Pancreatic Cancer Institute, Fudan University, Shanghai, P.R. China."
            },
            {
                "name": "Nengwen Ke",
                "org": "Department of Hepatobiliary and Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China."
            },
            {
                "name": "Ying Li",
                "org": "Department of Radiology, Peking University Cancer Hospital and Institute, Beijing, P.R. China."
            },
            {
                "name": "Yong Li",
                "org": "Department of General Surgery, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, P.R. China."
            },
            {
                "name": "Houjie Liang",
                "org": "Department of Oncology, Southwest Hospital, Third Military Medical University, Chongqing, P.R. China."
            },
            {
                "name": "An'an Liu",
                "org": "Department of General Surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, P.R. China."
            },
            {
                "name": "Jie Luo",
                "org": "Department of Pathology, China-Japan Friendship Hospital, Beijing, P.R. China."
            },
            {
                "name": "Quanxing Ni",
                "org": "Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Pancreatic Cancer Institute, Fudan University, Shanghai, P.R. China."
            },
            {
                "name": "Chengwei Shao",
                "org": "Department of Radiology, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, P.R. China."
            },
            {
                "name": "Boyong Shen",
                "org": "Department of General Surgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China."
            },
            {
                "name": "Weiqi Sheng",
                "org": "Department of Pathology, Shanghai Cancer Center, Fudan University, Shanghai, P.R. China."
            },
            {
                "name": "Bin Song",
                "org": "Department of Pancreatic Surgery, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, P.R. China."
            },
            {
                "name": "Jian Sun",
                "org": "Department of Hepatopancreatobiliary Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P.R. China."
            },
            {
                "name": "Chunlu Tan",
                "org": "Department of Hepatobiliary and Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China."
            },
            {
                "name": "Huangying Tan",
                "org": "Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing, P.R. China."
            },
            {
                "name": "Qiyun Tang",
                "org": "Department of Gastroenterology, Jiangsu People's Hospital, Nanjing Medical University, Nanjing, Jiangsu, P.R. China."
            },
            {
                "name": "Yingmei Tang",
                "org": "Department of Gastroenterology, The Second Affiliated Hospital of Kunming Medical University, Yunnan Research Center for Liver Diseases, Kunming, Yunnan, P.R. China."
            },
            {
                "name": "Xiaodong Tian",
                "org": "Department of General Surgery, Peking University First Hospital, Beijing, P.R. China."
            },
            {
                "name": "Jian Wang",
                "org": "Department of Biliary and Pancreatic Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China."
            },
            {
                "name": "Jie Wang",
                "org": "Department of General Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P.R. China."
            },
            {
                "name": "Wei Wang",
                "org": "Department of General Surgery, Huadong Hospital, Shanghai Medical College, Fudan University, Shanghai, P.R. China."
            },
            {
                "name": "Wei Wang",
                "org": "Department of Gastric and Pancreatic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P.R. China."
            },
            {
                "name": "Zheng Wu",
                "org": "Department of Hepatobiliary Surgery, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China."
            },
            {
                "name": "Jin Xu",
                "org": "Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Pancreatic Cancer Institute, Fudan University, Shanghai, P.R. China."
            },
            {
                "name": "Qiang Yan",
                "org": "Department of Surgery, Huzhou Central Hospital, Huzhou, Zhejiang, P.R. China."
            },
            {
                "name": "Ning Yang",
                "org": "Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, P.R. China."
            },
            {
                "name": "Yinmo Yang",
                "org": "Department of General Surgery, Peking University First Hospital, Beijing, P.R. China."
            },
            {
                "name": "Xiaoyu Yin",
                "org": "Department of Biliary and Pancreatic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P.R. China."
            },
            {
                "name": "Xianjun Yu",
                "org": "Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Pancreatic Cancer Institute, Fudan University, Shanghai, P.R. China."
            },
            {
                "name": "Chunhui Yuan",
                "org": "Department of General Surgery, Peking University Third Hospital, Peking University, Beijing, P.R. China."
            },
            {
                "name": "Shan Zeng",
                "org": "Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China."
            },
            {
                "name": "Guochao Zhang",
                "org": "Department of General Surgery, China-Japan Friendship Hospital, Beijing, P.R. China."
            },
            {
                "name": "Renchao Zhang",
                "org": "Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, P.R. China."
            },
            {
                "name": "Zhiwei Zhou",
                "org": "Department of Gastric and Pancreatic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P.R. China."
            },
            {
                "name": "Zhaohui Zhu",
                "org": "Department of Nuclear Medicine, Peiking Union Medical College Hospital, Beijing, P.R. China."
            },
            {
                "name": "Chenghao Shao",
                "org": "Department of General Surgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, P.R. China."
            }
        ],
        "venue": "International journal of oncology",
        "year": 2017
    },
    "EDmCP7Ic": {
        "id": "EDmCP7Ic",
        "title": " Preoperative Prediction of Pancreatic Neuroendocrine Neoplasms Grading Based on Enhanced CT Imaging: Validation of Deep Learning with a Convolutional Neural Network.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yanji Luo",
                "org": ""
            },
            {
                "name": "Xin Chen",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Chenyu Song",
                "org": ""
            },
            {
                "name": "Jingxian Shen",
                "org": ""
            },
            {
                "name": "Huanhui Xiao",
                "org": ""
            },
            {
                "name": "Minhu Chen",
                "org": ""
            },
            {
                "name": "Zi-Ping Li",
                "org": ""
            },
            {
                "name": "Bingsheng Huang",
                "org": ""
            },
            {
                "name": "Shi-Ting Feng",
                "org": ""
            }
        ],
        "venue": "Neuroendocrinology",
        "year": 2019
    },
    "cGddgHZz": {
        "id": "cGddgHZz",
        "title": "Comparison of five models for end-stage liver disease in predicting the survival rate of patients with advanced hepatocellular carcinoma",
        "abstract": "Prognosis of patients with advanced hepatocellular carcinoma (HCC) is under expectation. Life expectancy more than 3\u00a0months is one inclusion criteria for molecular targeted drugs in clinical trials. The main purpose of this research is to compare Model for End-Stage Liver Disease (MELD) and four MELD-based prognostic models in predicting the survival rate of advanced HCC patients. One hundred eighty-three patients with advanced HCC who were not amendable to standard anti-tumor therapy were retrospectively analyzed. Data were collected to classify patients according to MELD, Model for End-Stage Liver Disease with the incorporation of serum sodium (MELD-NA), Model for End-Stage Liver Disease to ascites and sodium (MELD-AS), integrated Model for End-Stage Liver Disease (iMELD), and Model for End-Stage Liver Disease to sodium (MESO) scores at diagnosis. 1-, 3-, and 6-month survivals were the end points used in the analysis. When predicting 1-month survival, MELD-AS, MELD, and MESO were the top 3 ranking staging systems. When predicting 3-month survival, area under the receiver operating characteristic curve (AUC) of MELD-AS is significantly higher than that of the other models (P\u2009<\u20090.05). When predicting 6-month survival, AUCs of MELD-AS and MELD-NA are significantly higher than those of the other models (P\u2009<\u20090.05). Cutoff point of MELD-AS is 23.11 with 40.5\u00a0% sensitivity and 93.8\u00a0% specificity at 1\u00a0month, 9.5 with 76.9\u00a0% sensitivity and 59.5\u00a0% specificity at 3\u00a0months, and 18.5 with 27.0\u00a0% sensitivity and 89.1\u00a0% specificity at 6\u00a0months. MELD-based scores of death group are significantly higher than those of survivors within 1 and 3\u00a0months (P\u2009<\u20090.001). Independent prognostic factors identified by multivariate analysis included persistent ascites, serum sodium, and thrombosis. MELD-AS is the best model in the prediction of short and intermediate survival among the five models for end-stage liver disease analyzed for Chinese advanced HCC patients.",
        "keywords": [
            "MELD",
            " MELD-based prognostic models",
            " Prognosis",
            " Hepatocellular carcinoma",
            " Survival time",
            " Standard anti-tumor therapy"
        ],
        "authors": [
            {
                "name": "Ying-Fen Hong",
                "org": "sun yat sen university"
            },
            {
                "name": "Zhan-Hong Chen",
                "org": "sun yat sen university"
            },
            {
                "name": "Xiao-Kun Ma",
                "org": "sun yat sen university"
            },
            {
                "name": "xing li",
                "org": "sun yat sen university"
            },
            {
                "name": "Dong-Hao Wu",
                "org": "sun yat sen university"
            },
            {
                "name": "jie chen",
                "org": "sun yat sen university"
            },
            {
                "name": "min dong",
                "org": "sun yat sen university"
            },
            {
                "name": "li wei",
                "org": "sun yat sen university"
            },
            {
                "name": "Tian-Tian Wang",
                "org": "sun yat sen university"
            },
            {
                "name": "Dan-Yun Ruan",
                "org": "sun yat sen university"
            },
            {
                "name": "Ze-Xiao Lin",
                "org": "sun yat sen university"
            },
            {
                "name": "Jing-Yun Wen",
                "org": "sun yat sen university"
            },
            {
                "name": "qu lin",
                "org": "sun yat sen university"
            },
            {
                "name": "Chang-Chang Jia",
                "org": "sun yat sen university"
            },
            {
                "name": "Xiang-Yuan Wu",
                "org": "sun yat sen university"
            }
        ],
        "venue": "Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine",
        "year": 2015
    },
    "48D3QwJK": {
        "id": "48D3QwJK",
        "title": "Endoplasmic reticulum stress induced Lox-1+ CD15+ polymorphonuclear myeloid-derived suppressor cells in hepatocellular carcinoma and associated with poor prognsis.",
        "abstract": "38Background: A recent study indicated that Lectin-type oxidized LDL receptor-1 (LOX-1) was a distinct surface marker for human polymorphonuclears myeloid-derived suppressor cells (PMN-MDSC). The present study was aimed to investigate the existence LOX-1 PMN-MDSC in hepatocellular carcinoma (HCC) patients, the latent mechanism and their association with clinical parameters. Methods: 30 HCC patients and 30 health control were included. LOX-1+CD15+ PMN-MDSCs were investigated. Results: LOX-1+CD15+ PMN-MDSC were significantly elevated in both WB and PBMC of HCC patients compared with healthy control. LOX-1+CD15+ PMN-MDSC were more abundant in PBMC than WB. Addition of PMN-MDSCs resulted in significantly reduced proliferation and IFN-\u03b3 production of T cells with a dosage dependent manner. LOX-1-CD15+ PMNs present no suppressive function. The suppression on T cell proliferation and IFN-\u03b3 production was reversed by ROS inhibitor and Arginase inhibitor. ROS level of LOX-1+CD15+ PMN by DCFDA were higher in LOX-1+...",
        "keywords": "",
        "authors": [
            {
                "name": "Xing Li",
                "org": "Sun Yat-sen University, Guangzhou, China;"
            },
            {
                "name": "Xiang-yuan Wu",
                "org": "Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;"
            },
            {
                "name": "Nan Jiang",
                "org": ""
            },
            {
                "name": "Yan-Fang Xing",
                "org": "Guangzhou Medical University, Guangzhou, China;"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Medical Oncology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;"
            },
            {
                "name": "Qu Lin",
                "org": "Sun Yat-sen University, Guangzhou, China;"
            }
        ],
        "venue": "Journal of Clinical Oncology",
        "year": 2018
    },
    "oeoTP136": {
        "id": "oeoTP136",
        "title": "Expression of enhancer of zeste homologue 2, correlated with HIF-1\u03b1, to refine relapse risk and predict poor outcome for breast cancer.",
        "abstract": "538 Background: Overexpression of enhancer of zeste homologue 2 (EZH2), a key component of polycomb proteins, has been linked to aggressive tumor behavior for breast cancer. In vitro, hypoxia-inducible factor 1 alpha (HIF-1\u03b1) transcriptionally activates EZH2 and promotes breast tumor initiating cells progression. Here, we characterized the clinicopathological effect of HIF-1\u03b1 and EZH2 in breast cancer patients. Methods: Tumor specimens from 410 luminal subtype breast cancer patients were used to construct tissue microarray. EZH2 and HIF-1\u03b1 level were examined by immunohistochemistry staining and Western blot analysis. With the 5-year follow up, the prognostic effect of EZH2 was subjected to multivariate analysis. Results: EZH2 and HIF-1\u03b1 were highly expressed in 99 (24.1%) and 272 (70.6%) patients, respectively. EZH2 overexpression was associated with high histological grade (P=0.030), lymphatic invasion (P=0.025), HER2 overexpression (P=0.005) and hypoxic condition (Pu003c0.001). Forced expression of EZH2 pr...",
        "keywords": "",
        "authors": [
            {
                "name": "Min Dong",
                "org": ""
            },
            {
                "name": "XinJuan Fan",
                "org": ""
            },
            {
                "name": "Zhan-Hong Chen",
                "org": ""
            },
            {
                "name": "Xing Li",
                "org": ""
            },
            {
                "name": "Tian tian Wang",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Qu Lin",
                "org": ""
            },
            {
                "name": "Jing-Yun Wen",
                "org": ""
            },
            {
                "name": "Xiao-Kun Ma",
                "org": ""
            },
            {
                "name": "Li Wei",
                "org": ""
            },
            {
                "name": "Dan-Yun Ruan",
                "org": ""
            },
            {
                "name": "Ze-Xiao Lin",
                "org": ""
            },
            {
                "name": "Quentin Liu",
                "org": ""
            },
            {
                "name": "XiangBo Wan",
                "org": ""
            },
            {
                "name": "Xiang-Yuan Wu",
                "org": ""
            }
        ],
        "venue": "Journal of Clinical Oncology",
        "year": 2017
    },
    "YDCNm7lX": {
        "id": "YDCNm7lX",
        "title": "Oncogenic ADAM28 induces gemcitabine resistance and predicts a poor prognosis in pancreatic cancer.",
        "abstract": "This study demonstrates that ADAM28 is overexpressed in pancreatic cancer, and closely involved in the regulation of gemcitabine resistance. Overexpression of ADAM28 is a novel prognostic biomarker in pancreatic cancer.",
        "keywords": [
            "ADAM28",
            "Drug metabolism",
            "Drug resistance",
            "Gemcitabine",
            "Overexpression",
            "Poor prognosis"
        ],
        "authors": [
            {
                "name": "Li Wei",
                "org": "Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Jing-Yun Wen",
                "org": "Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Xiao-Kun Ma",
                "org": "Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Dong-Hao Wu",
                "org": "Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Zhan-Hong Chen",
                "org": "Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Jiang-Long Huang",
                "org": "Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China. drhjl@aliyun.com."
            }
        ],
        "venue": "World journal of gastroenterology",
        "year": 2019
    },
    "7QRSuHfQ": {
        "id": "7QRSuHfQ",
        "title": "943 Promoter Hypermethylation of a Novel Tumor Suppressor Gene Chondrolectin in Colorectal Cancer",
        "abstract": "G A A b st ra ct s these findings. The present study seeks to identify biologic differences in methylation among these three racial/ethnic groups. Methods: We performed an array-based study of aberrantly methylated loci in CRCs and neighboring normal tissue using HumanMethylation450 arrays (Illumina). Paired FFPE CRC samples (n=42) and neighboring normal tissue were obtained from the case records of the pathology department at the University of Miami Hospital and Sylvester Comprehensive Cancer Center (Miami, FL). Samples were segregated into racial/ ethnic categories of black, Hispanic, and NHW and matched for age and stage. DNA was extracted from 10 micron thick colon tissue resection samples, with target enrichment, sequencing, and automated analysis performed using manufacturer protocols for the HumanMethylation450 array. Methylome-wide tumor vs. normal differential methylation was performed on each sample pair. Significantly methylated loci (FDRpu003c0.05) in \u226590% of samples in each ethnic group were prioritized, and overlap was sought between ethnic groups. Pathway and gene ontology analyses were conducted assuming a hypergeometric model with the MetaCore software. Results: 13 BNH, 18 Hispanic, and 11 NHW matched pairs of normal colon and CRC were included. 10 differentially methylated regions (DMRs) were significant both within and across all ethnic groups. All DMRs were hypermethylated, previously shown to be hypermethylated in cell lines, and several (e.g., MDFI, RYR2, OPLAH) were identified as top hits from published independent genome-wide methylation analyses. 73, 329, and 2379 DMRs were unique to Black, Hispanic, and NHW groups, respectively. The CpG sites that were differentially methylated (both hypoand hyper-methylation) were localized to intragenic and intergenic regions. Pathway analyses revealed unique signatures of methylation targets between ethnic groups. In contrast to Black and Hispanic datasets, the colorectal cancer (general schema) pathway was significant (FDRpu003c0.05) only in NHW. Conclusions: These results confirm common CRC methylation signals independent of racial/ ethnic labels and also reveal potential racialand ethnic-specific CRC methylation signatures. Clarification of these findings may contribute to the understanding of the phenotypic differences observed in patients with CRC among these groups.",
        "keywords": [],
        "authors": [
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "minhu chen",
                "org": ""
            },
            {
                "name": "ning zhang",
                "org": ""
            },
            {
                "name": "xiaoxing li",
                "org": ""
            },
            {
                "name": "sui peng",
                "org": ""
            },
            {
                "name": "yinglian xiao",
                "org": ""
            },
            {
                "name": "lixia xu",
                "org": ""
            }
        ],
        "venue": "Gastroenterology",
        "year": 2015
    },
    "vl0PWkkQ": {
        "id": "vl0PWkkQ",
        "title": "Early evaluation of sunitinib for the treatment of advanced gastroenteropancreatic neuroendocrine neoplasms via CT imaging: RECIST 1.1 or Choi Criteria?",
        "abstract": "The Choi criteria appear to be more sensitive and more precise than RECIST 1.1 in assessing the early response of advanced GEP-NENs treated with sunitinib.",
        "keywords": [
            "Computed tomography",
            "Gastroenteropancreatic neuroendocrine neoplasms",
            "Sunitinib",
            "Time to tumor progression"
        ],
        "authors": [
            {
                "name": "Yanji Luo",
                "org": "Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58th, The Second Zhongshan Road, Guangzhou, Guangdong, 510080, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, 58th, The Second Zhongshan Road, Guangzhou, Guangdong, 510080, China."
            },
            {
                "name": "Kun Huang",
                "org": "Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58th, The Second Zhongshan Road, Guangzhou, Guangdong, 510080, China."
            },
            {
                "name": "Yuan Lin",
                "org": "Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, 58th, The Second Zhongshan Road, Guangzhou, Guangdong, 510080, China."
            },
            {
                "name": "Minhu Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, 58th, The Second Zhongshan Road, Guangzhou, Guangdong, 510080, China."
            },
            {
                "name": "Ling Xu",
                "org": "Faculty of Medicine and Dentistry, University of Western Australia, Perth, Australia."
            },
            {
                "name": "Zi-Ping Li",
                "org": "Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58th, The Second Zhongshan Road, Guangzhou, Guangdong, 510080, China. liziping163@163.com."
            },
            {
                "name": "Shi-Ting Feng",
                "org": "Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58th, The Second Zhongshan Road, Guangzhou, Guangdong, 510080, China. fst1977@163.com."
            }
        ],
        "venue": "BMC cancer",
        "year": 2017
    },
    "Sy7XEUp6": {
        "id": "Sy7XEUp6",
        "title": "The efficacy of metronomic thalimomide and methotrexate for refractory/relapsed non-Hodgkin lymphoma.",
        "abstract": "e19508 Background: Relapsed and refractory non-Hodgkin\u2019s lymphomas (NHL) have a poor prognosis and represent a major treatment challenge. There is no standard of care for salvage regimens. Metronomic therapy offers a novel therapeutic strategy for cancer treatment endowed with an antiangiogenic effect. The aim of the present research was to evaluate the clinical efficacy and toxicity of metronomic administration of low-dose methotrexate and thalimomide in relapsed and refractory NHL. Methods: Data were collected from ninety-eight patients with the diagnosis of relapsed and refractory NHL who were admitted to the Third Affiliated Hospital of Sun Yat-Sen University from January 2009 to June 2013. The median age was 42 years (range, 14-78years).Of the ninety-eight patients treated, 28(28.6%) had follicular lymphoma; 17 (17.3 %) had marginal zone lymphoma; 35 (35.7 %) had diffuse large cell lymphoma; and 18 (18.3 %) had T-cell lymphoma. All had received at least two or more prior therapies. They received thal...",
        "keywords": "",
        "authors": [
            {
                "name": "Jing-Yun Wen",
                "org": "Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"
            },
            {
                "name": "Xiao-Kun Ma",
                "org": "Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"
            },
            {
                "name": "Dan-Yun Ruan",
                "org": "Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"
            },
            {
                "name": "Qu Lin",
                "org": "Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"
            },
            {
                "name": "Min Dong",
                "org": "Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"
            },
            {
                "name": "Xing Li",
                "org": "Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"
            },
            {
                "name": "Xiang-yuan Wu",
                "org": "Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"
            }
        ],
        "venue": "Journal of Clinical Oncology",
        "year": 2017
    },
    "fh0SEfqZ": {
        "id": "fh0SEfqZ",
        "title": "Netrin-1 up-regulates SENP1 expression in pancreatic cancer cells through activation of NF-kB",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Anan Liu",
                "org": ""
            },
            {
                "name": "Jun Chen",
                "org": ""
            },
            {
                "name": "L.G. Shi",
                "org": ""
            },
            {
                "name": "D.L. Chen",
                "org": ""
            },
            {
                "name": "L. Tang",
                "org": ""
            },
            {
                "name": "Chenghao Shao",
                "org": ""
            }
        ],
        "venue": "Pancreatology",
        "year": 2016
    },
    "OEPxqey0": {
        "id": "OEPxqey0",
        "title": "Staged Improvement in Awareness of Disease for Elderly Cancer Patients in Southern China",
        "abstract": "Background: In mainland China, awareness of disease of elderly cancer patients largely relies on the patientsu0027 families. We developed a staged procedure to improve their awareness of disease. Materials and Methods: Participants were 224 elderly cancer patients from 9 leading hospitals across Southern China. A questionnaire was given to the oncologists in charge of each patient to evaluate the interaction between family and patients, patient awareness of their disease and participation in medical decision-making. After first cycles of treatment, increased information of disease was given to patients with cooperation of the family. Then patient awareness of their disease and participation in medical decision-making was documented. Results: Among the 224 cancer elderly patients, 26 (11.6%) made decisions by themselves and 125 (55.8%) delegated their rights of decision- making to their family. Subordinate family members tended to play a passive role in decision-making significantly. Patients participating more in medical decision-making tended to know more about their disease. However, in contrast to the awareness of disease, patient awareness of violation of medical recommendations was reversely associated with their participation in medical decision-making. Improvement in awareness of diagnosis, stages and prognosis was achieved in about 20% elderly cancer patients. About 5% participated more actively in medical decision-making. Conclusions: Chinese elderly cancer patient awareness of disease and participation in medical decision-making is limited and relies on their family status. The staged procedure we developed to improve patient awareness of disease proved effective.",
        "keywords": "",
        "authors": [
            {
                "name": "Xing Li",
                "org": ""
            },
            {
                "name": "Min Dong",
                "org": ""
            },
            {
                "name": "Jing-Yun Wen",
                "org": ""
            },
            {
                "name": "Li Wei",
                "org": ""
            },
            {
                "name": "Xiao-Kun Ma",
                "org": ""
            },
            {
                "name": "Yan-Fang Xing",
                "org": ""
            },
            {
                "name": "Yun Deng",
                "org": ""
            },
            {
                "name": "Zhan-Hong Chen",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Dan-Yun Ruan",
                "org": ""
            },
            {
                "name": "Ze-Xiao Lin",
                "org": ""
            },
            {
                "name": "Tian-Tian Wang",
                "org": ""
            },
            {
                "name": "Dong-Hao Wu",
                "org": ""
            },
            {
                "name": "Xu Liu",
                "org": ""
            },
            {
                "name": "Hai-Tao Hu",
                "org": ""
            },
            {
                "name": "Jia-Yu Lin",
                "org": ""
            },
            {
                "name": "Zhuang-Hua Li",
                "org": ""
            },
            {
                "name": "Yuan-Chao Liu",
                "org": ""
            },
            {
                "name": "Qing Xia",
                "org": ""
            },
            {
                "name": "Chang-Chang Jia",
                "org": ""
            },
            {
                "name": "Xiang-yuan Wu",
                "org": ""
            },
            {
                "name": "Qu Lin",
                "org": ""
            }
        ],
        "venue": "Asian Pacific Journal of Cancer Prevention",
        "year": 2015
    },
    "Sw9x6mQj": {
        "id": "Sw9x6mQj",
        "title": "Efficacy of sorafenib in combination with gemcitabine and fluorouracil in metastatic renal-cell carcinoma: Preliminary result of a multicenter phase II study.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jun Guo",
                "org": ""
            },
            {
                "name": "Chuan Liang Cui",
                "org": ""
            },
            {
                "name": "H. Chen",
                "org": ""
            },
            {
                "name": "Xiaodong Xie",
                "org": ""
            },
            {
                "name": "Jianhua Chen",
                "org": ""
            },
            {
                "name": "Jun Liang",
                "org": ""
            },
            {
                "name": "F. Li",
                "org": ""
            },
            {
                "name": "T. S. Liu",
                "org": ""
            },
            {
                "name": "Zhihong Chi",
                "org": ""
            },
            {
                "name": "Lu Si",
                "org": ""
            },
            {
                "name": "Xi Nan Sheng",
                "org": ""
            },
            {
                "name": "Siming Li",
                "org": ""
            }
        ],
        "venue": "Journal of Clinical Oncology",
        "year": 2011
    },
    "YNi5BN5l": {
        "id": "YNi5BN5l",
        "title": "Serum albumin to globulin ratio as an indicator for the prognosis for cholangiocarcinoma.",
        "abstract": "e15605Background: Cholangiocarcinoma is a highly malignance with poor prognosis. To date,the prognostic factors remained unclear. Prior studies have demonstrated the prognostic value of pretreatment serum albumin to globulin ratio(AGR) in different types of cancer.This study was aimed to assess the predictive value of AGR on progression free survival (PFS) and overall survival(OS) in cholangiocarcinoma patients. Methods: We retrospectively studied 87 patients with cholangiocarcinoma who had documented pretreatment serum albumin and globulin levels from June 2003 to June 2007 in the Third Affiliated Hospital of Sun Yat-senUniversity.The primarystudyendpoint was OS.The predictive accuracy and discriminative ability of the AGR and other laboratoryindexes as well as tumor parameters for 1year survival after diagnosis were determined by ROC curves and the area under the ROC curve (AUC).The associations of preoperative AGR with clinicopathologic characteristics and prognosis were assessed. Univariate analysis a...",
        "keywords": "",
        "authors": [
            {
                "name": "Qu Lin",
                "org": "Department of Medical Oncology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;"
            },
            {
                "name": "Zhi-Huan Lin",
                "org": "Department of Medical Oncology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Oncology, Central Hospital of Hengyang, Hengyang, China;"
            },
            {
                "name": "Mingsheng Huang",
                "org": "Department of Radiology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;"
            },
            {
                "name": "Xing Li",
                "org": "Department of Medical Oncology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;"
            },
            {
                "name": "Junrong Jiang",
                "org": "Department of Medical Oncology, Third Affiliated Hospital of Sun Yat-sen University, Guagnzhou, China;"
            },
            {
                "name": "Min Dong",
                "org": "Department of Medical Oncology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;"
            },
            {
                "name": "Tian-Tian Wang",
                "org": "Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;"
            },
            {
                "name": "Dong-Hao Wu",
                "org": "Department of Medical Oncology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;"
            },
            {
                "name": "Xiao-Kun Ma",
                "org": "Department of Medical Oncology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China;"
            }
        ],
        "venue": "Journal of Clinical Oncology",
        "year": 2016
    },
    "KsQTuuJm": {
        "id": "KsQTuuJm",
        "title": "The Prognostic Value of aspartate aminotransferase to lymphocyte ratio and systemic immune-inflammation index for Overall Survival of Hepatocellular Carcinoma Patients Treated with palliative Treatments",
        "abstract": ": Lymphocytes were reported to play a significant part in host anticancer immune responses and influence tumour prognosis. Few studies have focused on the prognostic values of aspartate aminotransferase (AST) to lymphocyte ratio (ALRI), aspartate aminotransferase to platelet count ratio index (APRI) and systemic immune-inflammation index (SII) in hepatocellular carcinoma (HCC) treated with palliative treatments. : Five hundred and ninety-eight HCC patients treated with palliative therapies were retrospectively analysed. We randomly assigned patients into the training cohort (429 patients) and the validation cohort I (169 patients). Receiver operating characteristic (ROC) curves were used to identify the best cut-off values for the ALRI, APRI and SII in the training cohort and the values were further validated in the validation cohort I. Correlations between ALRI and other clinicopathological factors were also analysed. A prognostic nomogram including ALRI was established. We validated the prognostic value of the ALRI, SII and APRI with two independent cohorts, the validation cohort II of 82 HCC patients treated with TACE and the validation cohort III of 150 HCC patients treated with curative resection. In the training cohort and all the validation cohorts, univariate analyses by the method of Kaplan-Meier and multivariate analysis by Cox proportional hazards regression model were carried out to identify the independent prognostic factors. : The threshold values of ALRI, APRI and SII were 86.3, 1.37 and 376.4 respectively identified by ROC curve analysis in the training cohort. Correlation analysis showed that ALRI>86.3 was greatly associated with higher rates of Child-Pugh B&C, portal vein tumor thrombosis (PVTT) and ascites ( 0.05). Correspondingly, ALRI level of HCC patients with Child-Pugh B&C, PVTT and ascites was evidently higher than that of HCC patients with Child-Pugh A, without PVTT and without ascites ( 0.001). In the training cohort and the validation cohort I, II, III, the OS of patients with ALRI >86.3 was obviously shorter than patients with ALRI \u226486.3 (0.001). We identified ALRI as an independent prognostic factor by univariate and multivariate analyses both in training Cohort (HR=1.481, 0.004), validation cohort I (HR=1.511, 0.032), validation cohort II (HR=3.166, 0.005) and validation cohort III (HR=3.921, 0.010). The SII was identified as an independent prognostic factor in training cohort (HR=1.356, 0.020) and the validation cohort II (HR=2.678, 0.002). The prognostic nomogram including ALRI was the best in predicting 3-month, 6-month, 1-year, 2-year survival And OS among TNM, ALRI, ALRI-TNM and nomogram. : The ALRI was a novel independent prognostic index for the HCC patients treated with palliative treatments.",
        "keywords": [
            "ALRI",
            "hepatocellular carcinoma",
            "nomogram",
            "palliative treatment",
            "prognostic factors"
        ],
        "authors": [
            {
                "name": "Li-Yun Zhao",
                "org": ""
            },
            {
                "name": "Dong-Dong Yang",
                "org": ""
            },
            {
                "name": "Xiao-Kun Ma",
                "org": ""
            },
            {
                "name": "Meng-Meng Liu",
                "org": ""
            },
            {
                "name": "Dong-Hao Wu",
                "org": ""
            },
            {
                "name": "Xiao-Ping Zhang",
                "org": ""
            },
            {
                "name": "Dan-Yun Ruan",
                "org": ""
            },
            {
                "name": "Jin-Xiang Lin",
                "org": ""
            },
            {
                "name": "Jing-Yun Wen",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Qu Lin",
                "org": ""
            },
            {
                "name": "Min Dong",
                "org": ""
            },
            {
                "name": "Jing-Jing Qi",
                "org": ""
            },
            {
                "name": "Pei-Shan Hu",
                "org": ""
            },
            {
                "name": "Zhao-Lei Zeng",
                "org": ""
            },
            {
                "name": "Zhan-Hong Chen",
                "org": ""
            },
            {
                "name": "Xiang-Yuan Wu",
                "org": ""
            }
        ],
        "venue": "Journal of Cancer",
        "year": 2019
    },
    "cx5nT4GO": {
        "id": "cx5nT4GO",
        "title": "Carbohydrate antigen 19-9 as a prognostic biomarker in pancreatic neuroendocrine tumors.",
        "abstract": "Carbohydrate antigen 19-9 (CA19-9) is not generally considered to be a biomarker in pancreatic neuroendocrine tumors (pNETs), as the majority of pNETs present with a normal range of CA19-9. The present study aimed to evaluate the role of serum CA19-9 levels as a prognostic factor in a relatively large number of patients with pNETs. Consecutive patients were retrospectively collected from a single institution between June 2006 and February 2015. The receiver operating characteristic (ROC) curve and the area under the ROC curve were used to select the cut-off values for the baseline CA19-9 levels. The primary end point was set as overall survival. Potential factors associated with the abnormal elevation of CA19-9 expression levels in pNETs were also investigated. The cut-off value for CA19-9 was 16 U/ml as determined by the ROC curve, and for the area under the ROC curve it was 0.68. In total, 32.7% of patients (51/156) had CA19-9 expression levels higher than the cut-off value. Univariate analysis demonstrated that CA19-9 >16 U/ml was an adverse prognostic factor for patients' overall survival. The CA19-9 >16 U/ml group had a statistically higher proportion of tumor node metastasis (TNM) stage III or IV, as compared with the CA19-9 \u226416 U/ml group. To the best of our knowledge, the present study is the first to demonstrate that CA19-9 is a prognostic biomarker of pNETs, one that may reflect its aggressiveness and severity.",
        "keywords": [
            "biomarker",
            "carbohydrate antigen 19-9",
            "pancreatic neuroendocrine tumors",
            "prognosis"
        ],
        "authors": [
            {
                "name": "Guopei Luo",
                "org": "Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China."
            },
            {
                "name": "Kaizhou Jin",
                "org": "Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China."
            },
            {
                "name": "He Cheng",
                "org": "Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China."
            },
            {
                "name": "Chen Liu",
                "org": "Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China."
            },
            {
                "name": "Meng Guo",
                "org": "Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China."
            },
            {
                "name": "Yu Lu",
                "org": "Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China."
            },
            {
                "name": "Chao Yang",
                "org": "Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China."
            },
            {
                "name": "Jinzhi Xu",
                "org": "Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China."
            },
            {
                "name": "Wenquan Wang",
                "org": "Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China."
            },
            {
                "name": "Heli Gao",
                "org": "Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China."
            },
            {
                "name": "Shirong Zhang",
                "org": "Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China."
            },
            {
                "name": "Jiang Long",
                "org": "Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China."
            },
            {
                "name": "Jin Xu",
                "org": "Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China."
            },
            {
                "name": "Quanxing Ni",
                "org": "Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, P.R. China."
            },
            {
                "name": "Xianjun Yu",
                "org": "Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China."
            }
        ],
        "venue": "Oncology letters",
        "year": 2017
    },
    "Lds6BZkY": {
        "id": "Lds6BZkY",
        "title": "Alanine aminotransferase to hemoglobin ratio is an indicator for disease progression for hepatocellular carcinoma patients receiving transcatheter arterial chemoembolization",
        "abstract": "The prognosis of hepatocellular carcinoma (HCC) patients receiving transcatheter arterial chemoembolization (TACE) is far from being identified. The present study aimed to assess the role of blood cell counts, routine liver function tests, and alanine aminotransferase to hemoglobin ratio (AHR) in predicting the progression-free survival (PFS) of these patients. A total of 243 HCC patients receiving TACE were analyzed retrospectively. Cancer of the Liver Italian Program (CLIP) score system was indentified to be the best score system for this patient subgroup according to the Akaike information criterion (AIC) index and linear trend \u03c7 (2). Then, prognostic value of parameters was determined by integration into the CLIP score system. As a result, AHR was confirmed to be an independent predictor for the PFS of HCC patients receiving TACE (p\u2009=\u20090.001) with the other parameters failing to reach statistical significance. Moreover, AHR improved the performance of CLIP by adjusting into it, thus improving its discriminatory ability. AHR defined \u22640.4583 as low level and >0.4583 as high level. And, patients were also dichotomized into two groups accordingly. HCC patients receiving TACE with low AHR presented higher 1\u00a0year DCR (41.9 vs 18.1\u00a0%) compared with patients with high AHR levels. Furthermore, AHR level was associated with prognostic factors such as lower ALP, total bilirubin, and portal vein thrombosis. In summary, the present study firstly indentified AHR as an independent prognostic factor in HCC patients receiving TACE. The subgroup of HCC patients with lower AHR presented preferable disease control and were the idealistic candidates for TACE. ",
        "keywords": [
            "Alanine aminotransferase to hemoglobin ratio",
            "Hepatocellular carcinoma",
            "Prognosis",
            "Progression-free survival",
            "Transcatheter arterial chemoembolization"
        ],
        "authors": [
            {
                "name": "zhihuan lin",
                "org": "sun yat sen university"
            },
            {
                "name": "xing li",
                "org": "sun yat sen university"
            },
            {
                "name": "yingfen hong",
                "org": "sun yat sen university"
            },
            {
                "name": "xiaokun ma",
                "org": "sun yat sen university"
            },
            {
                "name": "donghao wu",
                "org": "sun yat sen university"
            },
            {
                "name": "mingsheng huang",
                "org": "sun yat sen university"
            },
            {
                "name": "zhanhong chen",
                "org": "sun yat sen university"
            },
            {
                "name": "jie chen",
                "org": "sun yat sen university"
            },
            {
                "name": "min dong",
                "org": "sun yat sen university"
            },
            {
                "name": "li wei",
                "org": "sun yat sen university"
            },
            {
                "name": "tiantian wang",
                "org": "sun yat sen university"
            },
            {
                "name": "danyun ruan",
                "org": "sun yat sen university"
            },
            {
                "name": "xiang zhong",
                "org": ""
            },
            {
                "name": "yanfang xing",
                "org": "guangzhou medical university"
            },
            {
                "name": "jingyun wen",
                "org": "sun yat sen university"
            },
            {
                "name": "xiangyuan wu",
                "org": "sun yat sen university"
            },
            {
                "name": "qu lin",
                "org": "sun yat sen university"
            }
        ],
        "venue": "Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine",
        "year": 2015
    },
    "PSEnNONk": {
        "id": "PSEnNONk",
        "title": "Clinicopathological features and prognostic validity of WHO grading classification of SI-NENs.",
        "abstract": "The clinicopathological characteristics of small intestinal neuroendocrine neoplasms (SI-NENs) and the prognostic validity of WHO grading classification for SI-NENs are still unknown in Asian patients.277 patients and 8315 patients with SI-NENs were retrieved respectively from eleven Chinese hospitals and Surveillance, Epidemiology, and End Results (SEER) cancer registry. Overall survival was used as the major study outcome. Survival analysis using Kaplan-Meier analysis with log-rank test and cox regression analysis were applied.Clinicopathological characteristics of SI-NENs were quite different among different races. Duodenum was the predominant tumor site in Chinese patients and Asian/Pacific Islander patients but not in white patients from SEER database. Patients with duodenal NENs tended to have more localized disease than patients with jejunal/ileal NENs which were confirmed by patients from SEER database. Grade 3 or poorly differentiated/undifferentiated tumor were more common and tumor size was significantly larger in ampullary NENs compared with that in non-ampullary duodenal NENs. As for the prognostic validity of WHO grading classification, survival between patients with grade 1 and grade 2 disease was not significantly different. Ki-67 index of 5% might be a better threshold between grade 1 and grade 2 than Ki-67 index of 2% in SI-NENs.Our study revealed that the clinicopathological characteristics of SI-NENs among different races were quite different. This might because duodenal NENs was much more common in Chinese patients and Asian/Pacific Islander patients. Duodenal NENs and jejunal/ileal NENs, ampullary and non-ampullary duodenal NENs shared different characteristics. Ki-67 index of 5% might be a better threshold between grade 1 and grade 2 in SI-NENs.",
        "keywords": [
            "Neuroendocrine neoplasms",
            "Small intestine",
            "Clinicopathological characteristics",
            "Tumor grade"
        ],
        "authors": [
            {
                "name": "Luohai Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, No.58 Zhongshan II Road, Yuexiu District, Guangzhou, 510080, China."
            },
            {
                "name": "Lin Zhou",
                "org": "Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
            },
            {
                "name": "Meng Zhang",
                "org": "Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China."
            },
            {
                "name": "Liang Shang",
                "org": "Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, No.324 Jingwu Road, Huaiyin District, Jinan, 250021, China."
            },
            {
                "name": "Panpan Zhang",
                "org": "Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis &amp; Translational Research under Ministry of Education, Peking University Cancer Hospital &amp; Beijing Cancer Hospital, No.52 Fucheng Road, Haidian District, Beijing, 100142, China."
            },
            {
                "name": "Wei Wang",
                "org": "Department of Gastric Surgery, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, China."
            },
            {
                "name": "Cheng Fang",
                "org": "Department of Gastric Surgery, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, China."
            },
            {
                "name": "Jingnan Li",
                "org": "Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China."
            },
            {
                "name": "Tianming Xu",
                "org": "Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China."
            },
            {
                "name": "Huangying Tan",
                "org": "Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing, China."
            },
            {
                "name": "Pan Zhang",
                "org": "Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing, China."
            },
            {
                "name": "Meng Qiu",
                "org": "Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China."
            },
            {
                "name": "Xianjun Yu",
                "org": "Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China."
            },
            {
                "name": "Kaizhou Jin",
                "org": "Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China."
            },
            {
                "name": "Ye Chen",
                "org": "Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Huishan Chen",
                "org": "Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China."
            },
            {
                "name": "Rong Lin",
                "org": "Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China."
            },
            {
                "name": "Qin Zhang",
                "org": "Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."
            },
            {
                "name": "Lin Shen",
                "org": "Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis &amp; Translational Research under Ministry of Education, Peking University Cancer Hospital &amp; Beijing Cancer Hospital, No.52 Fucheng Road, Haidian District, Beijing, 100142, China."
            },
            {
                "name": "Minhu Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, No.58 Zhongshan II Road, Yuexiu District, Guangzhou, 510080, China."
            },
            {
                "name": "Jie Li",
                "org": "Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis &amp; Translational Research under Ministry of Education, Peking University Cancer Hospital &amp; Beijing Cancer Hospital, No.52 Fucheng Road, Haidian District, Beijing, 100142, China. xiaotong10241@sina.com."
            },
            {
                "name": "Leping Li",
                "org": "Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, No.324 Jingwu Road, Huaiyin District, Jinan, 250021, China. lileping@medmail.com.cn."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, No.58 Zhongshan II Road, Yuexiu District, Guangzhou, 510080, China. chen0jie@hotmail.com."
            }
        ],
        "venue": "BMC cancer",
        "year": 2017
    },
    "2ReWqqxJ": {
        "id": "2ReWqqxJ",
        "title": "Over-reaching beyond disease activity: the influence of anxiety and medical economic burden on health-related quality of life in patients with inflammatory bowel disease.",
        "abstract": "Psychological factors and costs of medical care strongly impair HRQOL in IBD, independent of the disease activity. Psychological counseling and socioeconomic support programs should be considered for integration into the management of IBD patients.",
        "keywords": [
            "Crohn\u2019s disease",
            "anxiety",
            "depression",
            "health-related quality of life",
            "inflammatory bowel disease",
            "stress"
        ],
        "authors": [
            {
                "name": "Xia-Peng Luo",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China."
            },
            {
                "name": "Ren Mao",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China."
            },
            {
                "name": "Bai-Li Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China."
            },
            {
                "name": "Yun Qiu",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China."
            },
            {
                "name": "Sheng-Hong Zhang",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China."
            },
            {
                "name": "Yao He",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China."
            },
            {
                "name": "Zhi-Rong Zeng",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China."
            },
            {
                "name": "Shomron Ben-Horin",
                "org": "Department of Gastroenterology, Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel."
            },
            {
                "name": "Min-Hu Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China."
            }
        ],
        "venue": "Patient preference and adherence",
        "year": 2017
    },
    "trQrHfB7": {
        "id": "trQrHfB7",
        "title": "Clinical significance of plasma fibrinogen level in patients with prostate cancer.",
        "abstract": "e16077 Background: Most of malignant tumor patients have hypercoagulable state with plasma fibrinogen (Fib) levels increased. In this study, we aimed to investigate correlation of plasma Fib with routine prognostic factors of prostate cancer patients, including Gleason score, prostate specific antigen (PSA), TNM 7th Stage. Methods: From January 2007 to December 2012, 107 patients with prostate cancer and 44 cases of benign prostatic hyperplasia (BPH) were included in our study. Automated coagulation analyzer was used to determine the plasma fibrinogen levels. Results: The patients presented a mean age of 70.6 years, a mean PSA level of 28.73 ng/ml, clinically localized prostate cancer in 47 cases, locally advanced condition in 27cases, and distant metastatic disease in 33 cases. The fibrinogen levels were increased in cancer patients compared to that in patients with BPH (P = 0.031). Higher fibrinogen levels related to metastasis, higher TNM stage and increased PSA (p = 0.000, 0.041 and 0.004 respectively...",
        "keywords": "",
        "authors": [
            {
                "name": "Xiao-Kun Ma",
                "org": ""
            },
            {
                "name": "Jing-Yun Wen",
                "org": ""
            },
            {
                "name": "Zhan-Hong Chen",
                "org": ""
            },
            {
                "name": "Qu Lin",
                "org": ""
            },
            {
                "name": "Xing Li",
                "org": ""
            },
            {
                "name": "Min Dong",
                "org": ""
            },
            {
                "name": "Li Wei",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Tian\u2011Tian Wang",
                "org": ""
            },
            {
                "name": "Dan-Yun Ruan",
                "org": ""
            },
            {
                "name": "Ze-Xiao Lin",
                "org": ""
            },
            {
                "name": "Xiang-Bo Wan",
                "org": ""
            },
            {
                "name": "Xiang-yuan Wu",
                "org": ""
            }
        ],
        "venue": "Journal of Clinical Oncology",
        "year": 2017
    },
    "RyBRyamg": {
        "id": "RyBRyamg",
        "title": "Meta-analysis of postoperative adjuvant chemotherapy for patients with radical surgery of pancreatic cancer",
        "abstract": "Objective To evaluate the efficacy of adjuvant chemotherapy in patients with pancreatic cancer after radical surgery.Methods Randomized clinical studies of surgery plus postoperative adjuvant chemotherapy and surgery alone for patients with radical surgery of pancreatic cancer were selected from CBMdisc,CNKI,and PubMed databases.RevMan4.2 software was used for meta-analysis.Results Six reports were included in the meta-analysis and a total of 1 069 patients had been included.Compared with that of the patients underwent surgery alone,the 5-year survival rate of the patients underwent surgery plus adjuvant chemotherapy was not significantly elevated,with the odds ratio(OR) of 1.55(P=0.15,95%confidence interval=0.85~2.83).Conclusion A significant survival benefit is not seen in patients with pancreatic cancer after radical surgery plus postoperative adjuvant chemotherapy compared with patients after surgery alone.",
        "keywords": [
            "Pancreatic Neoplasms/surgery",
            "Neoadjuvant Therapy",
            "Meta-Analysis"
        ],
        "authors": [
            {
                "name": "WEN Jing-yun",
                "org": " Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-Sen University,Guangzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": " Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-Sen University,Guangzhou ,China"
            },
            {
                "name": "LIN Qu",
                "org": " Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-Sen University,Guangzhou ,China"
            },
            {
                "name": "DONG Min",
                "org": " Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-Sen University,Guangzhou ,China"
            },
            {
                "name": "WU Xiang-yuan",
                "org": " Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-Sen University,Guangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Misdiagnostics",
        "year": 2011
    },
    "GPHp32lg": {
        "id": "GPHp32lg",
        "title": "The Predictive Value of Albumin-to-Alkaline Phosphatase Ratio for Overall Survival of Hepatocellular Carcinoma Patients Treated with Trans-Catheter Arterial Chemoembolization Therapy.",
        "abstract": " We have previously reported the prognostic value of the albumin-to-alkaline phosphatase ratio (AAPR) for advanced hepatocellular carcinoma (HCC) patients who are not receiving any standard anticancer therapy. However, the prognostic value of the AAPR for HCC patients treated with trans-catheter arterial chemoembolization therapy (TACE) was not investigated.  We retrospectively analysed 372 HCC patients treated with TACE (the training cohort) and applied receiver operating characteristic curves (ROC curves) to identify the best cut-off value for the AAPR in this cohort. Then, univariate analyses by the Kaplan-Meier method and multivariate analysis by a Cox proportional hazards regression model were conducted. Both comparisons of the ROC curves and the likelihood ratio test (LRT) were employed to evaluate the abilities of different factors in predicting the survival of patients in this cohort. Finally, the prognostic value of the AAPR was validated in two cohorts: one included 202 HCC patients treated with supportive care (validation cohort I), and the other included 82 HCC patients treated with TACE (validation cohort II).  We identified 0.439 as the best cut-off value of the AAPR by ROC curve analysis. An AAPR > 0.439 was significantly correlated with a lower frequency of Child-Pugh grade B, portal vein tumour thrombus (PVTT), T3-4 and lymph node metastasis ( < 0.05). The median overall survival (OS) of the patients with an AAPR > 0.439 was significantly longer than that of those with an AAPR \u2264 0.439 (58.4 m vs 17.8 m, respectively,  < 0.001). The AAPR was identified as an independent prognostic factor after univariate and multivariate analyses ( = 0.636,  = 0.003). The independent prognostic value of the AAPR was also confirmed in validation cohorts I and II. Additionally, we substituted the AAPR for the Child-Pugh grade in the CLIP system and integrated the AAPR into the TNM system. We found that the area under the curve (AUC) of the AAPR-CLIP system was significantly larger than that of the CLIP and the TNM when predicting 3-month, 6-month, 1-year and 2-year survival ( < 0.05). There was no significant difference between the AUCs for the AAPR-CLIP and the AAPR-TNM. The LRT suggested that both AAPR-CLIP and AAPR-TNM had significantly larger \u03c72 values and smaller AIC values than that of their corresponding primary system ( < 0.05).  The AAPR was an independent prognostic index for the HCC patients treated with TACE. Both AAPR-CLIP and AAPR-TNM outperformed their corresponding primary system in predicting OS in the current study.",
        "keywords": [
            "albumin-to-alkaline phosphatase ratio",
            "hepatocellular carcinoma",
            "prognostic factor",
            "serum biomarker",
            "trans-catheter arterial chemoembolization therapy"
        ],
        "authors": [
            {
                "name": "Zhan-Hong Chen",
                "org": "Department of Medical Oncology of Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfengdong Road, Guangzhou, 510060, China."
            },
            {
                "name": "Xiao-Ping Zhang",
                "org": "Meihua Street Community Health Service Center, Yuexiu District Guangzhou, 510000, China."
            },
            {
                "name": "Xiu-Rong Cai",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China."
            },
            {
                "name": "Si-Dong Xie",
                "org": "Department of Radiology and Guangdong Key Laboratory of Liver Disease, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China."
            },
            {
                "name": "Meng-Meng Liu",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China."
            },
            {
                "name": "Jin-Xiang Lin",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China."
            },
            {
                "name": "Xiao-Kun Ma",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China."
            },
            {
                "name": "Qu Lin",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China."
            },
            {
                "name": "Min Dong",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China."
            },
            {
                "name": "Xiang-Yuan Wu",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China."
            },
            {
                "name": "Jing-Yun Wen",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China."
            },
            {
                "name": "Rui-Hua Xu",
                "org": "Department of Medical Oncology of Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfengdong Road, Guangzhou, 510060, China."
            }
        ],
        "venue": "Journal of Cancer",
        "year": 2018
    },
    "PGLEySZY": {
        "id": "PGLEySZY",
        "title": "Identification of prognostic value of lymphocyte-to-monocyte ratio in patients with advanced HBV-associated hepatocellular carcinoma.",
        "abstract": "206 Background: Inflammatory microenvironment plays an important role in the progression of HCC. Peripheral blood LMR, as a novel inflammatory biomarker combining an estimate of host immune homeostasis and tumor microenvironment, has been found to be a predictor for clinical outcomes in various malignancies. There have been no reports regarding the prognostic value of LMR in advanced HCC until now. We want to investigate the prognostic value of LMR in patients with advanced HBV-associated hepatocellular carcinoma. Methods: From September 2008 to June 2010, a total of 174 patients with HBV-associated advanced HCC without fever or signs of infections were analyzed. Clinicopathological parameters, including LMR, were evaluated to identify predictors of overall survival. Univariate and multivariate analyses were performed, using the Cox proportional hazards model. The best cutoff was determined with time-dependent receiver operating characteristic curve. Results: Univariate and multivariate analyses showed th...",
        "keywords": "",
        "authors": [
            {
                "name": "Zhan-Hong Chen",
                "org": ""
            },
            {
                "name": "Ying-Fen Hong",
                "org": ""
            },
            {
                "name": "Xiao-Kun Ma",
                "org": ""
            },
            {
                "name": "Xing Li",
                "org": ""
            },
            {
                "name": "Dong-Hao Wu",
                "org": ""
            },
            {
                "name": "Qu Lin",
                "org": ""
            },
            {
                "name": "Min Dong",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Li Wei",
                "org": ""
            },
            {
                "name": "Tian-Tian Wang",
                "org": ""
            },
            {
                "name": "Dan-Yun Ruan",
                "org": ""
            },
            {
                "name": "Jing-Yun Wen",
                "org": ""
            },
            {
                "name": "Xiang-yuan Wu",
                "org": ""
            }
        ],
        "venue": "Journal of Clinical Oncology",
        "year": 2016
    },
    "fjyIrSp9": {
        "id": "fjyIrSp9",
        "title": "Nomogram individually predicts the overall survival of patients with gastroenteropancreatic neuroendocrine neoplasms.",
        "abstract": "The current study aimed to establish a novel nomogram to predict the overall survival of individual Chinese patients with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). Furthermore, this study sought to externally validate this nomogram using the Surveillance, Epidemiology, and End Results (SEER) database.The records of 1183 patients with GEP-NENs treated at five high-capacity institutions in China between 2005 and 2015 were retrospectively analysed. In addition, 10\u2009236 GEP-NEN cases from the SEER database were included as an external validation set.A multivariate analysis using Cox proportional hazards (PHs) regression was performed, and a nomogram was constructed. Discrimination, calibration, and external validation were performed using the SEER data set. The multivariate Cox model indicated that age, tumour size, differentiation, lymph node metastases, and distant metastases were independent covariates associated with survival. With respect to the training set, the nomogram exhibited better discrimination power than TNM classification (Harrell's concordance index (C-index): 0.837 vs 0.784, P=0.006). Discrimination was also excellent and superior to that of TNM classification for the SEER-based validation set (C-index: 0.808 vs 0.717, P<0.001). The calibrated nomogram predicted a survival rate that closely corresponded to the actual survival rate.We developed a nomogram that predicted the 3- and 5-year overall survival rates of patients with GEP-NENs. Validation revealed excellent discrimination and calibration for this nomogram, suggesting that it exhibits satisfactory clinical utility that might improve individualised predictions of survival risks and lead to the creation of additional clinical therapies.British Journal of Cancer advance online publication: 26 September 2017; doi:10.1038/bjc.2017.315 www.bjcancer.com.",
        "keywords": "",
        "authors": [
            {
                "name": "Cheng Fang",
                "org": "Department of Gastric Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China."
            },
            {
                "name": "Wei Wang",
                "org": "Department of Gastric Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China."
            },
            {
                "name": "Xingyu Feng",
                "org": "Department of General Surgery, Guangdong General Hospital, Guangzhou, People's Republic of China."
            },
            {
                "name": "Jian Sun",
                "org": "Department of Biliopancreatic Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China."
            },
            {
                "name": "Yu Zhang",
                "org": "Department of Gastroenterology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China."
            },
            {
                "name": "Yujie Zeng",
                "org": "Department of Gastrointestinal Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China."
            },
            {
                "name": "Junjiang Wang",
                "org": "Department of General Surgery, Guangdong General Hospital, Guangzhou, People's Republic of China."
            },
            {
                "name": "Huishan Chen",
                "org": "Department of Gastroenterology, Nanfang Hospital of Southern Medical University, Guangzhou, People's Republic of China."
            },
            {
                "name": "Muyan Cai",
                "org": "State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China."
            },
            {
                "name": "Junzhong Lin",
                "org": "State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China."
            },
            {
                "name": "Minhu Chen",
                "org": "Department of Gastroenterology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China."
            },
            {
                "name": "Ye Chen",
                "org": "Department of Gastroenterology, Nanfang Hospital of Southern Medical University, Guangzhou, People's Republic of China."
            },
            {
                "name": "Yong Li",
                "org": "Department of General Surgery, Guangdong General Hospital, Guangzhou, People's Republic of China."
            },
            {
                "name": "Shengping Li",
                "org": "State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Gastroenterology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China."
            },
            {
                "name": "Zhiwei Zhou",
                "org": "Department of Gastric Surgery, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China."
            }
        ],
        "venue": "British journal of cancer",
        "year": 2017
    },
    "6u0K9N2n": {
        "id": "6u0K9N2n",
        "title": "Hepatitis B virus DNA negativity acts as a favorable prognostic factor in hepatocellular carcinoma patients.",
        "abstract": "This retrospective study was aimed to investigate the efficacy of prophylactic agents in hepatocellular carcinoma (HCC) patients receiving TACE and compare the difference between lamivudine and entecavir.A consecutive series of 203 HBV-related HCC patients receiving TACE were analyzed including 91 patients given prophylactic agents. Virologic events, defined as an increase in serum HBV DNA level to more than 1 log10 IU/ml higher than the nadir level, hepatitis flares due to HBV reactivation and progression free survival (PFS) were the main endpoints.Some 48 (69.6%) reached virologic response. Prophylaxis significantly reduced virologic events (8.8% vs 58.0%, p=0.000) and hepatitis flares (1.1% vs 13.4%, p=0.001). Patients presenting undetectable HBV DNA levels displayed a significantly improved PFS as compared to those who never achieved undetectable HBV DNA. Prophylaxis and e-antigen positivity were the only significant variables associated with virologic events. In addition, prophylaxis was the only independent protective factor for hepatitis flares. Liver cirrhosis, more cycles of TACE, HBV DNA negativity, a lower Cancer of the Liver Italian Program score, non-metastasis and no hepatitis flares were protective factors for PFS. Prophylactic lamivudine demonstrated similar efficacy as entecavir.Prophylactic agents are efficacious for prevention of HBV reactivation in HCC patients receiving TACE. Achievement of undetectable HBV DNA levels displayed a significant capability in improving PFS. Moreover, persistent tumor residual lesions, positive HBV DNA and hepatitis B flares might be causes of tumor progression in these patients.",
        "keywords": [],
        "authors": [
            {
                "name": "Xing Li",
                "org": "Department of Medical Oncology, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China E-mail : wuxiangy@mail.sysu.edu.cn, dongmin@mail.sysu.edu.cn."
            },
            {
                "name": "Xiang Zhong",
                "org": ""
            },
            {
                "name": "Zhan-Hong Chen",
                "org": ""
            },
            {
                "name": "Yan-Fang Xing",
                "org": ""
            },
            {
                "name": "Dong-Hao Wu",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Xiao-Kun Ma",
                "org": ""
            },
            {
                "name": "Qu Lin",
                "org": ""
            },
            {
                "name": "Jing-Yun Wen",
                "org": ""
            },
            {
                "name": "Li Wei",
                "org": ""
            },
            {
                "name": "Tian-Tian Wang",
                "org": ""
            },
            {
                "name": "Dan-Yun Ruan",
                "org": ""
            },
            {
                "name": "Ze-Xiao Lin",
                "org": ""
            },
            {
                "name": "Xiang-Yuan Wu",
                "org": ""
            },
            {
                "name": "Min Dong",
                "org": ""
            }
        ],
        "venue": "Asian Pacific journal of cancer prevention : APJCP",
        "year": 2014
    },
    "aqNYKhey": {
        "id": "aqNYKhey",
        "title": "Nomogram for preoperative estimation of long-term survival of patients who underwent curative resection with hepatocellular carcinoma beyond Barcelona clinic liver cancer stage A1",
        "abstract": "//      Dan-Yun Ruan 1,  * , Ze-Xiao Lin 1,  * , Tian-Tian Wang 1,  * , Hui Zhao 2 , Dong-Hao Wu 1 , Jie Chen 1 , Min Dong 1 , Qu Lin 1 , Xiang-Yuan Wu 1 , Yang Li 2     1 Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangdong, China    2 Department of Liver Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China    * These authors contributed equally to this work   Correspondence to:   Yang Li, email:  Liyang840920@hotmail.com    Xiang-Yuan Wu, email:  Wuxiangy@mail.sysu.edu.cn     Keywords:  hepatocellular carcinoma, Barcelona clinic liver cancer stage, resection, nomogram, survival    Received:  April 10, 2016\u00a0\u00a0\u00a0\u00a0\u00a0 Accepted:  August 10, 2016\u00a0\u00a0\u00a0\u00a0\u00a0 Published:  August 17, 2016     ABSTRACT    Background and Aims:  This retrospective cohort study developed a prognostic nomogram to predict the survival of hepatocellular carcinoma (HCC) patients diagnosed as beyond Barcelona clinic liver cancer stage A1 after resection and evaluated the possibility of using the nomogram as a treatment algorithm reference.    Results:  The predictors included in the nomogram were total tumour volume, Child-Turcotte-Pugh class, plasma fibrinogen and portal vein tumour thrombus. Patients diagnosed as beyond A1 were stratified into low-, medium- and high-risk groups using nomogram scores of 0 and 51 with the total points of 225. Patients within A1 exhibited similar recurrence-free survival (RFS) and overall survival (OS) rates compared with the low-risk group. Patients in the medium-risk group exhibited a similar OS but a worse RFS rates compared with patients within A1. The high-risk group was associated with worse RFS and OS rates compared with the patients within A1 (3-year RFS rates, 27.0% vs. 60.3%,  P  u003c 0.001; 3-year OS rates, 49.2% vs. 83.1%,  P  u003c 0.001).    Methods:  A total of 352 HCC patients undergoing curative resection from September 2003 to December 2012 were included to develop a nomogram to predict overall survival after resection. Univariate and multivariate survival analysis were used to identify prognostic factors. A visually orientated nomogram was constructed using a Cox proportional hazards model.    Conclusions:  This user-friendly nomogram offers an individualized preoperative recurrence risk estimation and stratification for HCC patients beyond A1 undergoing resection. Resection should be considered the first-line treatment for low-risk patients.",
        "keywords": "",
        "authors": [
            {
                "name": "Dan-Yun Ruan",
                "org": ""
            },
            {
                "name": "Ze-Xiao Lin",
                "org": ""
            },
            {
                "name": "Tian-Tian Wang",
                "org": ""
            },
            {
                "name": "Hui Zhao",
                "org": ""
            },
            {
                "name": "Dong-Hao Wu",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Min Dong",
                "org": ""
            },
            {
                "name": "Qu Lin",
                "org": ""
            },
            {
                "name": "Xiang-yuan Wu",
                "org": ""
            },
            {
                "name": "Yang Li",
                "org": ""
            }
        ],
        "venue": "Oncotarget",
        "year": 2016
    },
    "Vy17U43P": {
        "id": "Vy17U43P",
        "title": "Serum Golgi protein 73 is a prognostic rather than diagnostic marker in hepatocellular carcinoma.",
        "abstract": "Serum Golgi protein 73 (sGP73) is a candidate diagnostic biomarker for hepatocellular carcinoma (HCC). However, current evidence of its diagnostic value is conflicting, primarily due to the small sample sizes of previous studies, and its prognostic role in HCC also remains unclear. In the present study, sGP73 levels in 462 patients with HCC, 186 patients with liver cirrhosis, and 83 healthy controls were evaluated using ELISA, and it was identified that the median sGP73 levels were significantly higher in the HCC (18.7 ng/ml) and liver cirrhosis (18.5 ng/ml) patients than in the healthy controls (0 ng/ml; both P<0.001); however, the levels did not significantly differ between the HCC and liver cirrhosis groups (P=0.632). sGP73 had an inferior sensitivity and specificity for HCC diagnosis (27.79 and 77.96%, respectively) compared with \u03b1-fetoprotein (57.36 and 90.96%, respectively; P<0.001). In the HCC group, a high level of sGP73 was associated with aggressive clinicopathological features and independently predicted poor overall survival (OS) time (P<0.001). Additionally, in patients with resectable HCC, a high level of sGP73 was associated with significantly decreased disease-free survival (P<0.001) and OS (P=0.039) times compared with a low level of sGP73. This study demonstrated that sGP73 is unsuitable as a diagnostic marker for the early detection of HCC; however, it is an independent negative prognostic marker, providing a novel risk stratification factor and a potential therapeutic molecular target for HCC.",
        "keywords": [
            "Golgi protein 73",
            "hepatocellular carcinoma",
            "prognosis",
            "serum"
        ],
        "authors": [
            {
                "name": "Min Dong",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Zhan-Hong Chen",
                "org": "Department of Medical Oncology of Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China."
            },
            {
                "name": "Xing Li",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Xiao-Yun Li",
                "org": "Department of Medical Oncology, The First Affiliated Hospital, Henan University, Kaifeng, Henan 475001, P.R. China."
            },
            {
                "name": "Jing-Yun Wen",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Qu Lin",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Xiao-Kun Ma",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Li Wei",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Dan-Yun Ruan",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Ze-Xiao Lin",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Tian-Tian Wang",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Dong-Hao Wu",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Xiang-Yuan Wu",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            }
        ],
        "venue": "Oncology letters",
        "year": 2017
    },
    "pBvyB6Bp": {
        "id": "pBvyB6Bp",
        "title": "Effect of in situ Cs treatment on the field emission characteristics of amorphous diamond films",
        "abstract": "",
        "keywords": [
            "field emission",
            "thin films",
            "evaporation",
            "anodes",
            "cu",
            "caesium",
            "diamond",
            "work function",
            "cs",
            "amorphous materials",
            "c",
            "system testing"
        ],
        "authors": [
            {
                "name": "w g xie",
                "org": "sun yat sen university"
            },
            {
                "name": "j chen",
                "org": "sun yat sen university"
            },
            {
                "name": "s z deng",
                "org": "sun yat sen university"
            },
            {
                "name": "n s xu",
                "org": "sun yat sen university"
            }
        ],
        "venue": "",
        "year": 2003
    },
    "ok3a8VJB": {
        "id": "ok3a8VJB",
        "title": "Validation and ranking of seven staging systems of hepatocellular carcinoma.",
        "abstract": "The aim of the present study was to evaluate the ability of seven staging systems to predict 3- and 6-month and cumulative survival rates of patients with advanced hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC). Data were collected from 220 patients with HBV-associated HCC who did not receive any standard anticancer treatment. Participants were patients at The Third Affiliated Hospital of Sun Yat-sen University from September 2008 to June 2010. The participants were classified according to the Chinese University Prognostic Index (CUPI), the Cancer of the Liver Italian Program (CLIP), Japan Integrated Staging (JIS), China Integrated Score (CIS) systems, Barcelona Clinic Liver Cancer (BCLC), Okuda and tumor-node-metastasis (TNM) staging systems at the time of diagnosis and during patient follow-up. The sensitivity and specificity of the predictive value of each staging system for 3- and 6-month mortality were analyzed by relative operating characteristic (ROC) curve analysis with a non-parametric test being used to compare the area under curve (AUC) of the ROC curves. In addition, log-rank tests and Kaplan-Meier estimator survival curves were applied to compare the overall survival rates of the patients with HCC defined as advanced using the various staging systems, and the Akaike information criterion (AIC) and likelihood ratio tests (LRTs) were used to evaluate the predictive value for overall survival in patients with advanced HCC. Using univariate and multivariate Cox's model analyses, the factors predictive of survival were also identified. A total of 220 patients with HBV-associated HCC were analyzed. Independent prognostic factors identified by multivariate analyses included tumor size, \u03b1-fetoprotein levels, blood urea nitrogen levels, the presence or absence of portal vein thrombus, Child-Pugh score and neutrophil count. When predicting 3-month survival, the AUCs of CLIP, CIS, CUPI, Okuda, TNM, JIS and BCLC were 0.806, 0.772, 0.751, 0.731, 0.643, 0.754 and 0.622, respectively. When predicting 6-month survival, the AUCs of CLIP, CIS, CUPI, Okuda, TNM, JIS and BCLC were 0.828, 0.729, 0.717, 0.692, 0.664, 0.746 and 0.575, respectively. For 3-month mortality, the prognostic value of CLIP ranked highest, followed by CIS; for 6-month mortality, the prognostic value of CLIP also ranked highest, followed by JIS. No significant difference between the AUCs of CLIP and CIS (P>0.05) in their predictive value for 3-month mortality was observed. The AUC of CLIP was significantly higher compared with that of the other staging systems (P<0.05) for predicting 6-month mortality. The \u03c7(2) values from the LRTs of CLIP, CIS, CUPI, Okuda, TNM, JIS and BCLC were 75.6, 48.4, 46.7, 36.0, 21.0, 46.8 and 7.24, respectively. The AIC values of CLIP, CIS, CUPI, Okuda, TNM, JIS and BCLC were 1601.5, 1632.3, 1629.9, 1641.1, 1654.8, 1627.4 and 1671.1, respectively. CLIP exhibited the highest \u03c7(2) value and lowest AIC value, indicating that CLIP has the highest predictive value of cumulative survival rate. In the selected patients of the present study, CLIP was the staging system best able to predict 3- and 6-month and overall survival rates. CIS ranked second in predicting 3-month mortality.",
        "keywords": [
            "hepatitis B virus",
            "hepatocellular carcinoma",
            "neoplasm staging",
            "prognosis",
            "survival"
        ],
        "authors": [
            {
                "name": "Zhan-Hong Chen",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Ying-Fen Hong",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Jinxiang Lin",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Xing Li",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Dong-Hao Wu",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Jing-Yun Wen",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Dan-Yun Ruan",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Qu Lin",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Min Dong",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Li Wei",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Tian-Tian Wang",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Ze-Xiao Lin",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Xiao-Kun Ma",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Xiang-Yuan Wu",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Ruihua Xu",
                "org": "Department of Medical Oncology of Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China."
            }
        ],
        "venue": "Oncology letters",
        "year": 2017
    },
    "9NMN2xZ5": {
        "id": "9NMN2xZ5",
        "title": "Aberrant expression of enhancer of zeste homologue 2, correlated with HIF-1\u03b1, refines relapse risk and predicts poor outcome for breast cancer.",
        "abstract": "Overexpression of enhancer of zeste homologue 2 (EZH2), a key component of polycomb proteins, has been linked to aggressive tumor behavior in a variety of cancers. In vitro, hypoxia-inducible factor 1\u03b1 (HIF-1\u03b1) transcriptionally activates EZH2 and promotes the progression of breast tumor initiating cells. Here, we characterized the clinicopathological effect of EZH2 and HIF-1\u03b1 in 410 breast cancer patients. We examined EZH2 and HIF-1\u03b1 expression using immunohistochemistry and western blotting. We found that EZH2 and HIF-1\u03b1 were highly expressed in 99 (24.1%) and 272 (70.6%) patients, respectively. EZH2 overexpression was associated with lymphatic invasion (P=0.025), HER2 expression (P=0.005) and hypoxia (P<0.001). Overexpression of EZH2 predicted a poor 5-year overall survival (OS, 74.8 vs. 93.4%, P=0.001), disease-free survival (DFS, 72.2 vs. 88.6%, P=0.031), local failure-free survival (LFFS, 95.7 vs. 97.9%, P=0.045) and distant metastasis-free survival (DMFS, 75.4 vs. 90.5%, P=0.039). Multivariate analysis confirmed that EZH2 is an independent prognostic factor for OS, DFS and LFFS. Moreover, a positive correlation was identified between EZH2 and HIF-1\u03b1 (r=0.299, P<0.001). Importantly, tumors coexpressing HIF-1\u03b1 and EZH2 had a poorer OS (P=0.007). In conclusion, our study demonstrated that EZH2 is an independent negative prognostic biomarker for breast cancer. Tumors overexpressing HIF-1\u03b1 and EZH2 are more prone to disease progression.",
        "keywords": [
            "gene",
            "cell",
            "apoptosis",
            "cell cycle",
            "oncology",
            "molecular medicine",
            "cancer"
        ],
        "authors": [
            {
                "name": "Min Dong",
                "org": "Department of Medical Oncology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, P.R. China."
            },
            {
                "name": "Xin-Juan Fan",
                "org": "Department of Pathology, Gastrointestinal Institute, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, P.R. China."
            },
            {
                "name": "Zhan-Hong Chen",
                "org": "Department of Medical Oncology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, P.R. China."
            },
            {
                "name": "Tian-Tian Wang",
                "org": "Department of Medical Oncology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, P.R. China."
            },
            {
                "name": "Xing Li",
                "org": "Department of Medical Oncology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, P.R. China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Medical Oncology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, P.R. China."
            },
            {
                "name": "Qu Lin",
                "org": "Department of Medical Oncology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, P.R. China."
            },
            {
                "name": "Jing-Yun Wen",
                "org": "Department of Medical Oncology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, P.R. China."
            },
            {
                "name": "Xiao-Kun Ma",
                "org": "Department of Medical Oncology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, P.R. China."
            },
            {
                "name": "Li Wei",
                "org": "Department of Medical Oncology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, P.R. China."
            },
            {
                "name": "Dan-Yun Ruan",
                "org": "Department of Medical Oncology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, P.R. China."
            },
            {
                "name": "Ze-Xiao Lin",
                "org": "Department of Medical Oncology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, P.R. China."
            },
            {
                "name": "Quentin Liu",
                "org": "State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou 510065, P.R. China."
            },
            {
                "name": "Xiang-Yuan Wu",
                "org": "Department of Medical Oncology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, P.R. China."
            },
            {
                "name": "Xiang-Bo Wan",
                "org": "Department of Medical Oncology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, P.R. China."
            }
        ],
        "venue": "Oncology reports",
        "year": 2014
    },
    "W8I40RJA": {
        "id": "W8I40RJA",
        "title": "Platelet-to-lymphocyte ratio acts as a prognostic factor for patients with advanced hepatocellular carcinoma.",
        "abstract": "The platelet count, as an inflammation marker, is involved in the progress of tumor invasion. However, the prognostic value of platelet counts and the platelet-to-lymphocyte ratio (PLR) has not been investigated in patients with advanced hepatocellular carcinoma (HCC). This study aimed to determine the prognostic value of platelet counts and PLR in HCC patients. A total of 243 ethnic Chinese advanced HCC patients from two major hospitals, not receiving systemic sorafenib, were analyzed retrospectively. The prognostic value of differential blood cell counts and PLR for overall survival (OS) was determined by integrating the Cancer of the Liver Italian Program (CLIP) score system and model for end-stage liver disease by using a stepwise model of multivariate Cox regression. The Kaplan-Meier method and receiver operating characteristic (ROC) curves were utilized accordingly. PLR was confirmed to be an independent predictor for OS (p\u2009<\u20090.01), while the remaining parameters had no predictive value. Then, advanced HCC patients were dichotomized into two groups based on the PLR value (\u2264111.23 or >111.23), according to ROC analysis. Patients with a high PLR had a lower 3-month survival rate (37.6 vs. 57.6%) compared with patients with a low PLR. PLR was associated with aggressive malignant behavior, characterized by distant metastasis and portal vein thrombosis. Additionally, PLR was not associated with the CLIP score and Child-Pugh grade. PLR was identified as an independent prognostic factor for advanced HCC patients not receiving systemic sorafenib; the predictive ability of PLR partially relies on its association with the aggressive nature of HCC.",
        "keywords": [
            "Platelet\u2013lymphocyte ratio",
            " Hepatocellular carcinoma",
            " Prognosis",
            " Blood cell counts",
            " Score system"
        ],
        "authors": [
            {
                "name": "Xing Li",
                "org": "Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, People's Republic of China."
            },
            {
                "name": "Zhan-Hong Chen",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Yan-Fang Xing",
                "org": "Department of Nephrology,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou,China"
            },
            {
                "name": "Tian-Tian Wang",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Dong-Hao Wu",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Jing-Yun Wen",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Qu Lin",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Min Dong",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Li Wei",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Dan-Yun Ruan",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Ze-Xiao Lin",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Xiang-Yuan Wu",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Xiao-Kun Ma",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            }
        ],
        "venue": "Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine",
        "year": 2015
    },
    "8YXCsrVv": {
        "id": "8YXCsrVv",
        "title": "Inhibitory effect of the low-toxic exogenous aryl hydrocarbon receptor modulator 3'3-diindolylmethane on gastric cancer in mice.",
        "abstract": "3'3-Diindolylmethane (DIM) has been proved to exhibit anticancer properties in many solid tumors. In our previous study, we demonstrated that DIM inhibited SGC7901 cell proliferation by inducing apoptosis and delaying cell cycle progression. Herein, we further explored the anti-tumor effect of DIM on SGC-7901 tumor bearing mice. Tumors were excised, weighed, and tested by western blot and TdT-UTP nick-end labeling (TUNEL) assay. Blood samples were collected for biochemical analysis. The expression levels of AhR and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) protein were evaluated by western-blot assay. Our data show that with the increase of DIM dose (0, 5, 10, 20 mg/kg/day), AhR protein gradually decreased as CYP1A1 protein increased. The weight of the tumors found in the treated animals was significantly lower than that of the control group (0.845\u00b10.096 vs. 1.275\u00b10.236 g, 0.768\u00b10.161 vs. 1.275\u00b10.236 g, 0.607\u00b10.106 vs. 1.275\u00b10.236 g, P<0.05). TUNEL test showed that DIM induced increased apoptosis in the treatment groups in a dose-dependent manner. Blood tests also indicated that DIM showed no toxic effect on animal weight or liver and kidney function. These results indicated that DIM agent could be a safe and potent drug in therapy of gastric cancer.",
        "keywords": [
            "3\u20323-diindolylmethane",
            "aryl hydrocarbon receptor",
            "gastric cancer",
            "nude-mice model"
        ],
        "authors": [
            {
                "name": "Mingli Su",
                "org": "Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China."
            },
            {
                "name": "Chenchen Qian",
                "org": "Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China."
            },
            {
                "name": "Yumin Hu",
                "org": "Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China."
            },
            {
                "name": "Wenhua Lu",
                "org": "Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China."
            },
            {
                "name": "Rongkang Huang",
                "org": "Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510655, P.R. China."
            },
            {
                "name": "Minhu Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China."
            }
        ],
        "venue": "Oncology letters",
        "year": 2017
    },
    "zrGWdo0n": {
        "id": "zrGWdo0n",
        "title": "Comparison of a new prognostic system and other three current staging systems in predicting the survival rate of patients with HBV-associated advanced hepatocellular carcinoma.",
        "abstract": "347 Background: HBV infection is one of the main reasons for hepatocellular carcinoma(HCC). Patients with advanced HBV-associated HCC have poor prognosis. Life expectancy more than 3 months is one inclusion criteria for molecular targeted drugs in clinical trials. Prediction of 3-month OS and OS survival rate of advanced HCC patients is very important. A new prognostic system called PS-JIS system (proposed Performance Status combined Japan Integrated Staging system, variables and risk classification criteria are listed below) was established in 2015 and now we want to compare this new prognostic system and other three current staging systems in predicting the survival rate of patients with advanced HBV-associated HCC. Methods: From September 2008 to June 2010, 220 patients with advanced HCC who didn\u2019t receive anti-cancer therapy recommended by NCCN guidelines were analyzed. Data were collected to classify patients according to CLIP (Cancer of the Liver Italian Program), PS-JIS, GETCH(Groupe d\u2019etude et de ...",
        "keywords": "",
        "authors": [
            {
                "name": "Ying-Fen Hong",
                "org": ""
            },
            {
                "name": "Zhan-Hong Chen",
                "org": ""
            },
            {
                "name": "Qu Lin",
                "org": ""
            },
            {
                "name": "Min Dong",
                "org": ""
            },
            {
                "name": "Xing Li",
                "org": ""
            },
            {
                "name": "Jin-Yun Wen",
                "org": ""
            },
            {
                "name": "Xiao-Kun Ma",
                "org": ""
            },
            {
                "name": "Li Wei",
                "org": ""
            },
            {
                "name": "Dan-Yun Ruan",
                "org": ""
            },
            {
                "name": "Ze-Xiao Lin",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Tian-Tian Wang",
                "org": ""
            },
            {
                "name": "Xiang-yuan Wu",
                "org": ""
            }
        ],
        "venue": "Journal of Clinical Oncology",
        "year": 2016
    },
    "fZqoPrXz": {
        "id": "fZqoPrXz",
        "title": "Deceptive information and the financial burden for Chinese cancer patients.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Xing Li",
                "org": "Department of Medical Oncology, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, China."
            },
            {
                "name": "Yun Deng",
                "org": "Department of Radiation Oncology, Fifth Affiliated Hospital of Sun Yat-sen University, Zhu Hai, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Medical Oncology, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, China."
            },
            {
                "name": "Dan-Yun Ruan",
                "org": "Department of Medical Oncology, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, China."
            },
            {
                "name": "Zhan-Hong Chen",
                "org": "Department of Medical Oncology, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, China."
            },
            {
                "name": "Yan-Fang Xing",
                "org": "Department of Nephrology, Third Affiliated Hospital of Guangzhou Medical College, Guangzhou, China."
            },
            {
                "name": "Xiang-Yuan Wu",
                "org": "Department of Medical Oncology, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, China."
            },
            {
                "name": "Min Dong",
                "org": "Department of Medical Oncology, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, China."
            }
        ],
        "venue": "The Lancet. Oncology",
        "year": 2014
    },
    "jjkbbwHG": {
        "id": "jjkbbwHG",
        "title": "Analysis of risk factors of lymph node metastasis in rectal neuroendocrine neoplasms using multicenter data.",
        "abstract": "Rectal NENs patients with a larger tumor size, deeper tumor invasion or a higher G grade had a higher risk of regional lymph node metastasis.",
        "keywords": [
            "neuroendocrine neoplasms",
            "pathology",
            "rectal neoplasms",
            "risk factor",
            "\u00a0lymph node metastasis"
        ],
        "authors": [
            {
                "name": "Gengzhou Wei",
                "org": "Department of Medical College, South China University of Technology, Ganzhou, PR China."
            },
            {
                "name": "Xingyu Feng",
                "org": "Department of General Surgery, Guangdong General Hospital; Guangdong Academy of Medical Sciences, Guangzhou, PR China."
            },
            {
                "name": "Wei Wang",
                "org": "Department of Gastric Surgery, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, PR China."
            },
            {
                "name": "Yu Zhang",
                "org": "Department of Gastroenterology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China."
            },
            {
                "name": "Yujie Zeng",
                "org": "Department of Gastrointestinal Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, PR China."
            },
            {
                "name": "Minhu Chen",
                "org": "Department of Gastroenterology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China."
            },
            {
                "name": "Ye Chen",
                "org": "Department of Gastroenterology, Nanfang Hospital of Southern Medical University; Guangdong Provincial Key Laboratory of Gastroenterology,Guangzhou, PR China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Gastroenterology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China."
            },
            {
                "name": "Zhiwei Zhou",
                "org": "Department of Gastric Surgery, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, PR China."
            },
            {
                "name": "Yong Li",
                "org": "Department of General Surgery, Guangdong General Hospital; Guangdong Academy of Medical Sciences, Guangzhou, PR China."
            }
        ],
        "venue": "Future oncology (London, England)",
        "year": 2018
    },
    "DiBYYRbk": {
        "id": "DiBYYRbk",
        "title": "Erratum to: Neutrophil-to-lymphocyte ratio acts as a prognostic factor for patients with advanced hepatocellular carcinoma",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Xing\u00a0Li",
                "org": "The Institute of Human Virology, Zhongshan School of Medicine,Sun Yat-Sen University,Guangzhou,China"
            },
            {
                "name": "Zhan-Hong\u00a0Chen",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Xiao-Kun\u00a0Ma",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Jie\u00a0Chen",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Dong-Hao\u00a0Wu",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Qu\u00a0Lin",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Min\u00a0Dong",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Li\u00a0Wei",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Tian-Tian\u00a0Wang",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Dan-Yun\u00a0Ruan",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Ze-Xiao\u00a0Lin",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Yan-Fang\u00a0Xing",
                "org": "Department of Nephrology,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou,China"
            },
            {
                "name": "Yun\u00a0Deng",
                "org": "Department of Radiation Oncology,The Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,China"
            },
            {
                "name": "Xiang-Yuan\u00a0Wu",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            },
            {
                "name": "Jin-Yun\u00a0Wen",
                "org": "Department of Medical Oncology,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China"
            }
        ],
        "venue": "Tumor Biology",
        "year": 2016
    },
    "9G0gb0dr": {
        "id": "9G0gb0dr",
        "title": "Lymphocyte-to-monocyte ratio predicts survival of patients with hepatocellular carcinoma after curative resection.",
        "abstract": "To investigate the prognostic value of preoperative lymphocyte-to-monocyte ratio (LMR) in patients with hepatocellular carcinoma (HCC) undergoing curative hepatectomy.Clinicopathological data of 210 hepatitis B virus (HBV)-associated HCC patients who were treated by radical hepatic resection between 2003 and 2010 were retrospectively analyzed. None of the patients received any preoperative anticancer therapy or intraoperative radiofrequency ablation. The diagnosis was confirmed by pathological examination after surgery. Absolute peripheral blood lymphocyte and monocyte counts were derived from serum complete blood cell count before surgery, and LMR was calculated by dividing lymphocyte count by monocyte count. The best cutoff was determined by receiver operating characteristics (ROC) curve analysis. Correlations between LMR levels and clinicopathological features were assessed using the \u03c7(2) test. Survival outcomes were estimated using the Kaplan-Meier method and compared by the log-rank test. Univariate and multivariate analyses were performed to evaluate the prognostic impact of LMR and other clinicopathological factors on overall survival (OS) and recurrence-free survival (RFS), using the Cox proportional hazards model.The optimal cutoff value of LMR for survival analysis was 3.23, which resulted in the most appropriate sensitivity of 55.3% and specificity of 74.7%, with the area under the curve (AUC) of 0.66 (95%CI: 0.593-0.725). All patients were dichotomized into either a low (\u2264 3.23) LMR group (n = 66) or a high (> 3.23) LMR group (n = 144). A low preoperative LMR level was significantly correlated with the presence of cirrhosis, elevated levels of total bilirubin and larger tumor size. Patients with a low LMR level had significantly reduced 5-year OS (61.9% vs 83.2%, P < 0.001) and RFS (27.8% vs 47.6%, P = 0.009) compared to those with a high LMR level. Multivariate analyses indicated that a lower LMR level was a significantly independent predictor of inferior OS (P = 0.003) and RFS (P = 0.006). Subgroup analysis indicated that survival outcome was significantly more favorable in cirrhotic patients with LMR > 3.23. However, there were no differences between low and high LMR groups for OS and RFS in non-cirrhotic patients.Preoperative LMR was demonstrated for the first time to serve as an independent prognostic factor in HBV-associated HCC patients after curative resection. Prospective studies with larger cohorts for validation are warranted.",
        "keywords": [
            "Hepatocellular carcinoma",
            "Liver resection",
            "Lymphocyte-to-monocyte ratio",
            "Prognosis",
            "Prognostic factor"
        ],
        "authors": [
            {
                "name": "Ze-Xiao Lin",
                "org": "Ze-Xiao Lin, Dan-Yun Ruan, Dong-Hao Wu, Xiao-Kun Ma, Jie Chen, Zhan-Hong Chen, Xing Li, Tian-Tian Wang, Qu Lin, Jing-Yun Wen, Xiang-Yuan Wu, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Dan-Yun Ruan",
                "org": "Ze-Xiao Lin, Dan-Yun Ruan, Dong-Hao Wu, Xiao-Kun Ma, Jie Chen, Zhan-Hong Chen, Xing Li, Tian-Tian Wang, Qu Lin, Jing-Yun Wen, Xiang-Yuan Wu, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Yang Li",
                "org": "Ze-Xiao Lin, Dan-Yun Ruan, Dong-Hao Wu, Xiao-Kun Ma, Jie Chen, Zhan-Hong Chen, Xing Li, Tian-Tian Wang, Qu Lin, Jing-Yun Wen, Xiang-Yuan Wu, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Dong-Hao Wu",
                "org": "Ze-Xiao Lin, Dan-Yun Ruan, Dong-Hao Wu, Xiao-Kun Ma, Jie Chen, Zhan-Hong Chen, Xing Li, Tian-Tian Wang, Qu Lin, Jing-Yun Wen, Xiang-Yuan Wu, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Xiao-Kun Ma",
                "org": "Ze-Xiao Lin, Dan-Yun Ruan, Dong-Hao Wu, Xiao-Kun Ma, Jie Chen, Zhan-Hong Chen, Xing Li, Tian-Tian Wang, Qu Lin, Jing-Yun Wen, Xiang-Yuan Wu, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Jie Chen",
                "org": "Ze-Xiao Lin, Dan-Yun Ruan, Dong-Hao Wu, Xiao-Kun Ma, Jie Chen, Zhan-Hong Chen, Xing Li, Tian-Tian Wang, Qu Lin, Jing-Yun Wen, Xiang-Yuan Wu, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Zhan-Hong Chen",
                "org": "Ze-Xiao Lin, Dan-Yun Ruan, Dong-Hao Wu, Xiao-Kun Ma, Jie Chen, Zhan-Hong Chen, Xing Li, Tian-Tian Wang, Qu Lin, Jing-Yun Wen, Xiang-Yuan Wu, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Xing Li",
                "org": "Ze-Xiao Lin, Dan-Yun Ruan, Dong-Hao Wu, Xiao-Kun Ma, Jie Chen, Zhan-Hong Chen, Xing Li, Tian-Tian Wang, Qu Lin, Jing-Yun Wen, Xiang-Yuan Wu, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Tian-Tian Wang",
                "org": "Ze-Xiao Lin, Dan-Yun Ruan, Dong-Hao Wu, Xiao-Kun Ma, Jie Chen, Zhan-Hong Chen, Xing Li, Tian-Tian Wang, Qu Lin, Jing-Yun Wen, Xiang-Yuan Wu, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Qu Lin",
                "org": "Ze-Xiao Lin, Dan-Yun Ruan, Dong-Hao Wu, Xiao-Kun Ma, Jie Chen, Zhan-Hong Chen, Xing Li, Tian-Tian Wang, Qu Lin, Jing-Yun Wen, Xiang-Yuan Wu, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Jing-Yun Wen",
                "org": "Ze-Xiao Lin, Dan-Yun Ruan, Dong-Hao Wu, Xiao-Kun Ma, Jie Chen, Zhan-Hong Chen, Xing Li, Tian-Tian Wang, Qu Lin, Jing-Yun Wen, Xiang-Yuan Wu, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Xiang-Yuan Wu",
                "org": "Ze-Xiao Lin, Dan-Yun Ruan, Dong-Hao Wu, Xiao-Kun Ma, Jie Chen, Zhan-Hong Chen, Xing Li, Tian-Tian Wang, Qu Lin, Jing-Yun Wen, Xiang-Yuan Wu, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China."
            }
        ],
        "venue": "World journal of gastroenterology : WJG",
        "year": 2015
    },
    "76WQ4cIa": {
        "id": "76WQ4cIa",
        "title": "Efficacy of Prophylactic Entecavir for Hepatitis B Virus-Related Hepatocellular Carcinoma Receiving Transcatheter Arterial Chemoembolization.",
        "abstract": "Hepatitis B virus (HBV) reactivation was reported to be induced by transcatheter arterial chemoembolization (TACE) in HBV-related hepatocellular carcinonma (HCC) patients with a high incidence. The effective strategy to reduce hepatitis flares due to HBV reactivation in this specific group of patients was limited to lamivudine. This retrospective study was aimed to investigate the efficacy of prophylactic entecavir in HCC patients receiving TACE.A consecutive series of 191 HBV-related HCC patients receiving TACE were analyzed including 44 patients received prophylactic entecavir. Virologic events, defined as an increase in serum HBV DNA level to more than 1 log10 copies/ml higher than nadir the level, and hepatitis flares due to HBV reactivation were the main endpoints.Patients with or without prophylactic were similar in host factors and the majorities of characteristics regarding to tumor factors, HBV status, liver function and LMR. Notably, cycles of TACE were parallel between the groups. Ten (22.7%) patients receiving prophylactic entecavir reached virologic response. The patients receiving prophylactic entecavir presented significantly reduced virologic events (6.8% vs 54.4%, p=0.000) and hepatitis flares due to HBV reactivation (0.0% vs 11.6%, p=0.039) compared with patients without prophylaxis. Kaplan-Meier analysis illustrated that the patients in the entecavir group presented significantly improved virologic events free survival (p=0.000) and hepatitis flare free survival (p=0.017). Female and Eastern Cooperative Oncology Group (ECOG) performance status 2 was the only significant predictors for virological events in patients without prophylactic antiviral. Rescue antiviral therapy did not reduce the incidence of hepatitis flares due to HBV reactivation.Prophylactic entecavir presented promising efficacy in HBV-related cancer patients receiving TACE. Lower performance status and female gender might be the predictors for HBV reactivation in these patients.",
        "keywords": [],
        "authors": [
            {
                "name": "Xing Li",
                "org": "Department of Medical Oncology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China E-mail : wuxiangy@mail.sysu.edu.cn; gzliqu@163.com."
            },
            {
                "name": "Xiang Zhong",
                "org": ""
            },
            {
                "name": "Zhan-Hong Chen",
                "org": ""
            },
            {
                "name": "Tian-Tian Wang",
                "org": ""
            },
            {
                "name": "Xiao-Kun Ma",
                "org": ""
            },
            {
                "name": "Yan-Fang Xing",
                "org": ""
            },
            {
                "name": "Dong-Hao Wu",
                "org": ""
            },
            {
                "name": "Min Dong",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Dan-Yun Ruan",
                "org": ""
            },
            {
                "name": "Ze-Xiao Lin",
                "org": ""
            },
            {
                "name": "Jing-Yun Wen",
                "org": ""
            },
            {
                "name": "Li Wei",
                "org": ""
            },
            {
                "name": "Xiang-Yuan Wu",
                "org": ""
            },
            {
                "name": "Qu Lin",
                "org": ""
            }
        ],
        "venue": "Asian Pacific journal of cancer prevention : APJCP",
        "year": 0
    },
    "0q7M4xae": {
        "id": "0q7M4xae",
        "title": "Poor oncologic outcomes of hepatocellular carcinoma patients with intra-abdominal infection after hepatectomy.",
        "abstract": "To evaluate the impact of postoperative infectious complications on hepatocellular carcinoma following curative hepatectomy.We performed a retrospective analysis of 200 hepatocellular carcinoma patients who underwent hepatectomy at our institution between September 2003 and June 2011. The patients' demographics, clinicopathological characteristics and postoperative infectious complications were analyzed. The Clavien-Dindo classification was adopted to assess the severity of complications. The dynamic change in the neutrophil-to-lymphocyte ratio, defined as the absolute neutrophil count divided by the absolute lymphocyte count, after surgery was also investigated. The observation endpoints for this study were recurrence-free survival and overall survival of the patients. Statistical analysis of the survival curves was performed using the Kaplan-Meier method and the log-rank test. The prognostic value of each variable for predicting prognosis was assessed via multivariate Cox proportional hazards regression analysis. The cutoff score for each variable was selected based on receiver operating characteristic curve analysis. All statistical tests were two-sided, and significance was set at P < 0.05.The median age of the patients was 49 years, and the majority of patients were male (86%) and had been infected with hepatitis B virus (86%). The 30-d postoperative infectious complication rate was 34.0% (n = 68). Kaplan-Meier survival analysis revealed that postoperative infection was significantly correlated with tumor recurrence (P < 0.001). The postoperative intra-abdominal infection group exhibited a worse prognosis than the non-intra-abdominal infection group (P < 0.001). A significantly increased incidence of postoperative intra-abdominal infection was observed in the patients with hepatic cirrhosis (P = 0.028), concomitant splenectomy (P = 0.007) or vascular invasion (P = 0.026). The patients who had an elevated postoperative neutrophil-to-lymphocyte ratio change (> 1.643) clearly exhibited poorer recurrence-free survival than those who did not (P = 0.009), although no significant correlation was observed between overall survival and the change in the postoperative neutrophil-to-lymphocyte ratio. Based on multivariate analysis, hepatitis B surface antigen positivity, Child-Turcotte-Pugh class B, an elevated postoperative neutrophil-to-lymphocyte ratio change and intra-abdominal infection were significant predictors of poor recurrence-free survival. Hepatic cirrhosis, the maximal tumor diameter and intra-abdominal infection were significant predictors of overall survival.Postoperative intra-abdominal infection adversely affected oncologic outcomes, and the change in postoperative neutrophil-to-lymphocyte ratio was a good indicator of tumor recurrence in hepatocellular carcinoma patients after curative hepatectomy.",
        "keywords": [
            "Hepatectomy",
            "Hepatocellular carcinoma",
            "Neutrophil-to-lymphocyte ratio change",
            "Postoperative intra-abdominal infection",
            "Prognosis"
        ],
        "authors": [
            {
                "name": "Dan-Yun Ruan",
                "org": "Dan-Yun Ruan, Ze-Xiao Lin, Xing Li, Dong-Hao Wu, Tian-Tian Wang, Jie Chen, Qu Lin, Xiang-Yuan Wu, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Ze-Xiao Lin",
                "org": "Dan-Yun Ruan, Ze-Xiao Lin, Xing Li, Dong-Hao Wu, Tian-Tian Wang, Jie Chen, Qu Lin, Xiang-Yuan Wu, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Yang Li",
                "org": "Dan-Yun Ruan, Ze-Xiao Lin, Xing Li, Dong-Hao Wu, Tian-Tian Wang, Jie Chen, Qu Lin, Xiang-Yuan Wu, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Nan Jiang",
                "org": "Dan-Yun Ruan, Ze-Xiao Lin, Xing Li, Dong-Hao Wu, Tian-Tian Wang, Jie Chen, Qu Lin, Xiang-Yuan Wu, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Xing Li",
                "org": "Dan-Yun Ruan, Ze-Xiao Lin, Xing Li, Dong-Hao Wu, Tian-Tian Wang, Jie Chen, Qu Lin, Xiang-Yuan Wu, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Dong-Hao Wu",
                "org": "Dan-Yun Ruan, Ze-Xiao Lin, Xing Li, Dong-Hao Wu, Tian-Tian Wang, Jie Chen, Qu Lin, Xiang-Yuan Wu, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Tian-Tian Wang",
                "org": "Dan-Yun Ruan, Ze-Xiao Lin, Xing Li, Dong-Hao Wu, Tian-Tian Wang, Jie Chen, Qu Lin, Xiang-Yuan Wu, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Jie Chen",
                "org": "Dan-Yun Ruan, Ze-Xiao Lin, Xing Li, Dong-Hao Wu, Tian-Tian Wang, Jie Chen, Qu Lin, Xiang-Yuan Wu, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Qu Lin",
                "org": "Dan-Yun Ruan, Ze-Xiao Lin, Xing Li, Dong-Hao Wu, Tian-Tian Wang, Jie Chen, Qu Lin, Xiang-Yuan Wu, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China."
            },
            {
                "name": "Xiang-Yuan Wu",
                "org": "Dan-Yun Ruan, Ze-Xiao Lin, Xing Li, Dong-Hao Wu, Tian-Tian Wang, Jie Chen, Qu Lin, Xiang-Yuan Wu, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China."
            }
        ],
        "venue": "World journal of gastroenterology : WJG",
        "year": 2015
    },
    "mQBUZ9rw": {
        "id": "mQBUZ9rw",
        "title": "Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma.",
        "abstract": "Our results signify how non-tumour-intrinsic properties in the desmoplastic microenvironment can be exploited to reinstate immunosurveillance, providing readily translatable combination strategies to empower HCC immunotherapy.",
        "keywords": [
            "cancer immunobiology",
            "fibrosis",
            "hepatocellular carcinoma",
            "immunotherapy",
            "liver immunology"
        ],
        "authors": [
            {
                "name": "Man Liu",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Jingying Zhou",
                "org": "School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China."
            },
            {
                "name": "Xiaoyu Liu",
                "org": "School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China."
            },
            {
                "name": "Yu Feng",
                "org": "School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China."
            },
            {
                "name": "Weiqin Yang",
                "org": "School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China."
            },
            {
                "name": "Feng Wu",
                "org": "Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China."
            },
            {
                "name": "Otto Ka-Wing Cheung",
                "org": "School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China."
            },
            {
                "name": "Hanyong Sun",
                "org": "Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, Shanghai, China."
            },
            {
                "name": "Xuezhen Zeng",
                "org": "School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China."
            },
            {
                "name": "Wenshu Tang",
                "org": "School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China."
            },
            {
                "name": "Myth T S Mok",
                "org": "School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China."
            },
            {
                "name": "John Wong",
                "org": "Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China."
            },
            {
                "name": "Philip Chun Yeung",
                "org": "Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China."
            },
            {
                "name": "Paul Bo San Lai",
                "org": "Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China."
            },
            {
                "name": "Zhiwei Chen",
                "org": "AIDS Institute, Department of Microbiology and Research Center for Infection and Immunity, The University of Hong Kong, Hong Kong, China."
            },
            {
                "name": "Hongchuan Jin",
                "org": "Labortaory of Cancer Biology, Key Laboratory of Biotherapy in Zhejiang, Sir Runrun Shaw hospital, Medical School of Zhejiang University, Hang Zhou, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Stephen Lam Chan",
                "org": "Department of Clinical Oncology, The Chinese University of Hong Kong, Hong Kong, China."
            },
            {
                "name": "Anthony W H Chan",
                "org": "Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China."
            },
            {
                "name": "Ka Fai To",
                "org": "State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Hong Kong, China."
            },
            {
                "name": "Joseph J Y Sung",
                "org": "State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China."
            },
            {
                "name": "Minhu Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Alfred Sze-Lok Cheng",
                "org": "State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China."
            }
        ],
        "venue": "Gut",
        "year": 2019
    },
    "J6n07H9g": {
        "id": "J6n07H9g",
        "title": "Modified CLIP score with the albumin-bilirubin grade retains prognostic value in HBV-related hepatocellular carcinoma patients treated with trans-catheter arterial chemoembolization therapy.",
        "abstract": " The  (CLIP) score is commonly used for prognosis prediction of hepatocellular carcinoma (HCC). The CLIP includes the Child-Pugh grade, which is relatively subjective, for hepatic encephalopathy assessment. A newly developed scoring system called albumin-bilirubin grade (ALBI grade), consists of albumin and bilirubin to assess liver function reserve objectively. Here, we substituted the ALBI grade for the Child-Pugh grade to establish the ALBI-CLIP scoring system and validated its prognostic value in hepatitis B virus (HBV)-related HCC patients treated with trans-catheter arterial chemoembolization (TACE) therapy.  We retrospectively analyzed HBV-related HCC patients who received TACE therapy. Baseline characteristics were collected and evaluated to classify patients according to ALBI-CLIP, CLIP and TNM systems. Univariate analyses using the Kaplan-Meier method and the log-rank test, as well as multivariate analysis using the Cox proportional hazards regression model, were conducted to detect independent prognostic factors for overall survival. Receiver operating characteristic (ROC) curves and a likelihood ratio test (LRT) were both utilized to compare the values of ALBI-CLIP, CLIP and TNM staging systems in predicting survival.  With a total of 389 patients included in the current study, 301 (77.4%) and 88 (22.6%) were classified as Child-Pugh grade A and B, respectively. However, 152 (39.1%), 227 (58.4%) and 10 (2.5%) patients were correspondingly classified into ALBI grade 1, 2 and 3. The areas under the curves of ALBI-CLIP, CLIP and TNM systems were 0.804, 0.778 and 0.734, respectively, for predicting 3-month survival; 0.796, 0.778 and 0.733, respectively, for 6-month survival; 0.697, 0.687 and 0.644, respectively, for 1-year survival; and 0.618, 0.612 and 0.569, respectively, for 2-year survival. The LRT indicated that the ALBI-CLIP and the CLIP had similar values of \u03c7 and Akaike information criterion (AIC) while the TNM system had the smallest \u03c7 value (\u03c7 = 12.1, 11.9, 10.5; AIC = 2620.2, 2620.5, 2621.1 for ALBI-CLIP, CLIP and TNM, respectively).  In conclusion, our present study suggested that the ALBI-CLIP scoring system retained the prognostic value of the CLIP in HBV-related HCC treated with TACE therapy.",
        "keywords": [
            "CLIP",
            "albumin-bilirubin grade",
            "hepatitis B virus",
            "hepatocellular carcinoma",
            "prognosis",
            "transcatheter arterial chemoembolization"
        ],
        "authors": [
            {
                "name": "Xiu-Rong Cai",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China."
            },
            {
                "name": "Zhan-Hong Chen",
                "org": "Department of Medical Oncology of Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfengdong Road, Guangzhou, 510060, China."
            },
            {
                "name": "Meng-Meng Liu",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China."
            },
            {
                "name": "Jin-Xiang Lin",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China."
            },
            {
                "name": "Xiao-Ping Zhang",
                "org": "Meihua Street Community Health Service Center, Yuexiu District Guangzhou, 510000, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China."
            },
            {
                "name": "Qu Lin",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China."
            },
            {
                "name": "Xiao-Kun Ma",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China."
            },
            {
                "name": "Jing-Yun Wen",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China."
            },
            {
                "name": "Si-Dong Xie",
                "org": "Department of Radiology and Guangdong Key Laboratory of Liver Disease, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China."
            },
            {
                "name": "Xiang-Yuan Wu",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China."
            },
            {
                "name": "Min Dong",
                "org": "Department of Medical Oncology and Guangdong Key Laboratory of Liver Disease, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou, 510630, China."
            }
        ],
        "venue": "Journal of Cancer",
        "year": 2018
    },
    "5dFz3pmw": {
        "id": "5dFz3pmw",
        "title": "Loss of expression and prognosis value of alpha-internexin in gastroenteropancreatic neuroendocrine neoplasm.",
        "abstract": "The expression of \u03b1-internexin was highly heterougeneous in different sites of GEP-NENs. The reduced/loss of expression of \u03b1-internexin was closely related to tumors with aggressiveness and patient's adverse prognosis. The hypermethylation of the regulatory region examined may be an important epigenetic regulation mechanism of \u03b1-internexin deficiency in subtype of GI-NENs.",
        "keywords": [
            "Gastroenteropancreatic neuroendocrine neoplasm. Alpha-internexin. Expression. Prognosis"
        ],
        "authors": [
            {
                "name": "Yuhong Wang",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, No.58 Zhongshan II Road, Yuexiu District, Guangzhou, 510080, China."
            },
            {
                "name": "Yuanjia Chen",
                "org": "Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China."
            },
            {
                "name": "Xiaoxing Li",
                "org": "State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China."
            },
            {
                "name": "Wanming Hu",
                "org": "Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, China."
            },
            {
                "name": "Yu Zhang",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, No.58 Zhongshan II Road, Yuexiu District, Guangzhou, 510080, China."
            },
            {
                "name": "Luohai Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, No.58 Zhongshan II Road, Yuexiu District, Guangzhou, 510080, China."
            },
            {
                "name": "Minhu Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, No.58 Zhongshan II Road, Yuexiu District, Guangzhou, 510080, China. chenminhu@mail.sysu.edu.cn."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, No.58 Zhongshan II Road, Yuexiu District, Guangzhou, 510080, China. chen0jie@hotmail.com."
            }
        ],
        "venue": "BMC cancer",
        "year": 2018
    },
    "Voj3il8Y": {
        "id": "Voj3il8Y",
        "title": "Development and Validation of a Prognostic Nomogram to Guide Decision-Making for High-Grade Digestive Neuroendocrine Neoplasms.",
        "abstract": "The high-grade neuroendocrine neoplasms of the digestive system are rare malignancies with great heterogeneity. An overall survival nomogram was developed and externally validated in this study. Two subgroups were classified by the nomogram score, and platinum-based chemotherapy may not bring clinical benefit for the low-risk patients.",
        "keywords": [
            "Development and validation",
            "Digestive system",
            "High grade",
            "Neuroendocrine neoplasm",
            "Prognostic nomogram"
        ],
        "authors": [
            {
                "name": "Zhenyu Lin",
                "org": "Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China."
            },
            {
                "name": "Haihong Wang",
                "org": "Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China."
            },
            {
                "name": "Yixuan Zhang",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China."
            },
            {
                "name": "Guiling Li",
                "org": "Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China."
            },
            {
                "name": "Guoliang Pi",
                "org": "Department of Radiation Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China."
            },
            {
                "name": "Xianjun Yu",
                "org": "Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China."
            },
            {
                "name": "Yaobing Chen",
                "org": "Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China."
            },
            {
                "name": "Kaizhou Jin",
                "org": "Fudan University Shanghai Cancer Center, Shanghai, People's Republic of China."
            },
            {
                "name": "Liangkai Chen",
                "org": "Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China."
            },
            {
                "name": "Shengli Yang",
                "org": "Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China."
            },
            {
                "name": "Ying Zhu",
                "org": "Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China."
            },
            {
                "name": "Gang Wu",
                "org": "Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China chenojie@hotmail.com taozhangxh@hust.edu.cn."
            },
            {
                "name": "Tao Zhang",
                "org": "Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China chenojie@hotmail.com taozhangxh@hust.edu.cn."
            }
        ],
        "venue": "The oncologist",
        "year": 2019
    },
    "BOzCQ0vN": {
        "id": "BOzCQ0vN",
        "title": "Circular RNA circCDK13 suppresses cell proliferation, migration and invasion by modulating the JAK/STAT and PI3K/AKT pathways in liver cancer.",
        "abstract": "Circular RNAs have recently been disclosed as potential biomarkers for human cancers. This study aimed to characterize the expression and function of a novel circular RNA, circCDK13, in liver cancer progression, as well as to elucide the underlying mechanisms. For this purpose, circCDK13 expression was quantitatively analyzed by RT-PCR in various liver cancer cell lines and human cancerous tissues. The migration, cell cycle progression, proliferation and invasion of liver cancer cells with an enhanced circCDK13 expression were evaluated by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt (MTS) assay, flow cytometry and the Transwell culture system. Microarray and western blot analyses were performed to explore the underlying signaling mechanisms. The role of circCDK13 in liver cancer was finally examined by tumorigenicity assay using nude mice. The results revealed that circCDK13 expression was suppressed in various liver cancer lines and tissue samples from patients with liver cancer (hepatocellular carcinoma). The induced overexpression of circCDK13 in the liver cancer cells markedly inhibited their migration rates, altered cell cycle progression, and suppressed the cell migratory and invasive capacities. Microarray analysis also identified numerous downstream genes regulated by circCDK13, particularly those in the Janus tyrosine kinase\u00a0(JAK)/signal transducer and activator of transcription\u00a0(STAT) and phosphoinositide\u00a03-kinase\u00a0(PI3K)/AKT signaling pathways. The results of the tumorigenicity assay revealed that circCDK13 overexpression significantly inhibited liver cancer progression in nude mice. On the whole, the findings of this study indicate that circCDK13 is a novel circular RNA that suppresses liver cancer progression, and that these suppressive effects are possibly mediated via the JAK/STAT and PI3K/AKT signaling pathways.",
        "keywords": "",
        "authors": [
            {
                "name": "Qu Lin",
                "org": "Department of Medical Oncology, \u03a4he Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Yun-Biao Ling",
                "org": "Guangdong Key Laboratory of Liver Disease Research, \u03a4he Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Jun-Wei Chen",
                "org": "Guangdong Key Laboratory of Liver Disease Research, \u03a4he Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Chu-Ren Zhou",
                "org": "Guangdong Key Laboratory of Liver Disease Research, \u03a4he Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Medical Oncology, \u03a4he Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Xing Li",
                "org": "Department of Medical Oncology, \u03a4he Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            },
            {
                "name": "Ming-Sheng Huang",
                "org": "Guangdong Key Laboratory of Liver Disease Research, \u03a4he Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China."
            }
        ],
        "venue": "International journal of oncology",
        "year": 2018
    },
    "9zgG5APd": {
        "id": "9zgG5APd",
        "title": "Treatment of tibial plateau fractures via combined anterior and posterior approaches",
        "abstract": "Objective To study the outcome of treatment of tibial plateau fractures by internal fixation with buttress plates and bone grafting via combined anterior and posterior approaches.Methods 25 patients with posterior shearing fractures of tibial plateau were treated with open reduction,bone grafting and buttress plate fixation via combined anterior and posterior approaches.They were followed up and evaluated by the progress of fracture healing,functional recovery and surgical effect of satisfaction.Results 25 patients were followed up for 12~24 months.According to Rasmussen knee function score system,at 1 year after operation,there were 13 excellent cases,8 good and 4 fair.According to surgical effect of satisfaction,there were 9 cases of very satisfactory,13 satisfactory and 3 intermediate.Conclusions A complex tibial plateau fracture with posterior shearing fracture can be fully exposed and treated through combined anterior and posterior approaches.Though familiar understanding of the popliteal fossa anatomy is required,the clinical outcome is good.",
        "keywords": [
            "posterior approach",
            "fracture fixation internal",
            "bone grafting",
            "anterior approach",
            "tibial plateau fracture"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Dept of Orthopaedics,the People\u2032s Hospital of Putuo District,Shanghai ,China"
            },
            {
                "name": "HU Sun-jun",
                "org": "Dept of Orthopaedics,the People\u2032s Hospital of Putuo District,Shanghai ,China"
            },
            {
                "name": "CHEN Jian",
                "org": "Dept of Orthopaedics,the People\u2032s Hospital of Putuo District,Shanghai ,China"
            }
        ],
        "venue": "Journal of Clinical Orthopaedics",
        "year": 2012
    },
    "5wWAMsJu": {
        "id": "5wWAMsJu",
        "title": "Posterior shearing fractures of tibial plateau treated with buttress plates via a posterior approach",
        "abstract": "Objective To study the outcome of posterior shearing fractures of tibial plateau with buttress plates via a posterior approach.Methods 16 patients with single posterior shearing fractures of tibial plateau were operated via a posterior approach and followed up retrospectively.The progress of fracture healing and radiographs were recorded.Results All patients were followed up for 12~24 months.According to Rasmussen knee function score system at 1 year post operation,there were 10 excellent cases,4 good and 2 fair.Conclusions Even though familiar understanding of the popliteal fossa anatomy is required,a posterior approach can provide sufficient space for exposing and reducing single posterior fractures of tibial plateau,while a buttress plate has stable fixation for the fragments.",
        "keywords": [
            "fracture fixation",
            "posterior approach",
            "buttress plate",
            "internal",
            "tibial plateau fracture"
        ],
        "authors": [
            {
                "name": "HU Sun-jun",
                "org": ""
            },
            {
                "name": "CHEN Jian",
                "org": ""
            },
            {
                "name": "CHEN Jie",
                "org": ""
            },
            {
                "name": "YU Guang-rong",
                "org": ""
            },
            {
                "name": "ZHANG Shi-min",
                "org": ""
            }
        ],
        "venue": "Journal of Clinical Orthopaedics",
        "year": 2012
    },
    "BlGdQOZY": {
        "id": "BlGdQOZY",
        "title": "Surgical management of type C fractures of distal humerus",
        "abstract": "",
        "keywords": [
            "fracture fixation",
            "humeral fractures/surgery",
            "internal"
        ],
        "authors": [
            {
                "name": "ZHANG Yi-gong",
                "org": ""
            },
            {
                "name": "WEI Guo-jun",
                "org": ""
            },
            {
                "name": "MI Zhong-xiang",
                "org": ""
            },
            {
                "name": "Chen Jie",
                "org": ""
            }
        ],
        "venue": "Journal of Clinical Orthopaedics",
        "year": 2006
    },
    "NO2kAXLs": {
        "id": "NO2kAXLs",
        "title": "Minimally invasive treatment of thoracic and lumbar fracture under spinal endoscopy",
        "abstract": "Objective To study the method and indication of minimally invasive treatment of thoracic and lumbar fracture. Methods 11cases with thoracic and lumbar fractures were treated with transpedicle screw-rod system internal fixation under spinal endoscopy through 4 1.5 cm incisions.Results 11 cases got vertebral height restoration and kyphosis correction.1 was complicated with delayed wound healing due to wound rim necrosis. No other complication was found. Conclusions It has advantages of less trauma and less blood loss, which can provide identical effect of vertebral height restoration and kyphosis correction as regular surgery in the treatment of thoracic and lumbar fracture under spinal endoscopy.",
        "keywords": [
            "surgical procedures",
            "spinal endoscopy",
            "spinal fractures",
            "minimally invasive"
        ],
        "authors": [
            {
                "name": "CHEN Jian",
                "org": "Dept of Orthopaedics, People\u2032s Hospital of Putuo District, Shanghai , China"
            },
            {
                "name": "YU Kai-le",
                "org": "Dept of Orthopaedics, People\u2032s Hospital of Putuo District, Shanghai , China"
            },
            {
                "name": "CHEN Jie",
                "org": "Dept of Orthopaedics, People\u2032s Hospital of Putuo District, Shanghai , China"
            },
            {
                "name": "YE Zheng",
                "org": "Dept of Orthopaedics, People\u2032s Hospital of Putuo District, Shanghai , China"
            },
            {
                "name": "ZHAO Jie",
                "org": "Dept of Orthopaedics, People\u2032s Hospital of Putuo District, Shanghai , China"
            }
        ],
        "venue": "Journal of Clinical Orthopaedics",
        "year": 2006
    },
    "VXYZtlG9": {
        "id": "VXYZtlG9",
        "title": "Treatment of primarily Lisfranc joint injuries with open reduction and internal minimal plate fixation",
        "abstract": "Objective To investigate the clinical effects of minimal plate fixation for the treatment of tarsometatarsal joint injuries.Methods Twenty-one patients with an isolated or complex primarily Lisfranc joint injury were treated with open reduction and minimal plate internal fixation.Results All the wounds healed primiary,with two cases had partial incision necrosis and healed after dress changing.All the patients were followed up for 9\uff5e16(12.2\u00b13.6) months.Internal fixation was removed in 9\uff5e16 months.The mean AOFAS scores were 73\uff5e95(86.5\u00b19.8).The results were excellent in 10 cases,good in 9 and fair in 2.Conclusions A primary treatment with minimal plate for the Lisfranc joint injuries can provide stable fixation and early exercise.",
        "keywords": [
            "minimal plates",
            "fracture fixation",
            "tarsometatarsal joint injuries",
            "internal"
        ],
        "authors": [
            {
                "name": "CHEN Jian",
                "org": "Dept of Orthopaedics,People\u2032s Hospital of Putuo District,Shanghai ,China"
            },
            {
                "name": "HU Sun-jun",
                "org": "Dept of Orthopaedics,People\u2032s Hospital of Putuo District,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Dept of Orthopaedics,People\u2032s Hospital of Putuo District,Shanghai ,China"
            },
            {
                "name": "YE Zheng",
                "org": "Dept of Orthopaedics,People\u2032s Hospital of Putuo District,Shanghai ,China"
            },
            {
                "name": "MIAO Jia-qing",
                "org": "Dept of Orthopaedics,People\u2032s Hospital of Putuo District,Shanghai ,China"
            },
            {
                "name": "WANG Xian-hui",
                "org": "Dept of Orthopaedics,People\u2032s Hospital of Putuo District,Shanghai ,China"
            }
        ],
        "venue": "Journal of Clinical Orthopaedics",
        "year": 2010
    },
    "xeij9sR2": {
        "id": "xeij9sR2",
        "title": "Applied anatomy and clinical significance of the fourth and fifth tarsometatarsal joints",
        "abstract": "Objective To study the structure of the fourth and fifth tarsometatarsal joints and to evaluate the motion ability by measuring their anatomic parameters.Methods Ten fresh-frozen cadaver foot specimens were used to measure the transverse and longitudinal diameters of the fourth and fifth tarsometatarsal joints,including angle of the two joints,and the tilt angle of the proximal fifth metatarsal joint.Results \u2460The average transverse diameter of distal fourth metatarsal articular surface was(8.58\u00b10.30)mm,longitudinal diameter(12.89\u00b10.52)mm while the proximal fourth metatarsal articular surface was(8.65\u00b10.29)mm,longitudinal diameter(13.0\u00b10.47)mm.The average transverse diameter of distal fifth metatarsal articular surface was(10.61\u00b10.98)mm,longitudinal diameter(12.22\u00b10.46)mm while the proximal fifth metatarsal articular surface was(8.65\u00b10.29)mm,longitudinal diameter was(13.0\u00b10.47)mm.\u2461The average tilt angle of fifth metatarsal articular surface was(51.5\u00b0\u00b12.8\u00b0) while the articular angle of tarsometatarsal joints on cuboid(147.2\u00b0\u00b18.5\u00b0).\u2462Both the fourth and fifth tarsometatarsal joints were flat joints,hence the longitudinal axis was longer.The fifth tarsometatarsal joint was triangle while the fourth one was rectangle.Conclusion Since the fourth and fifth tarsometatarsal joints are flat joints,there bear have relatively large action scope in different plane especially in sagittal plane.The action scope of these two joints should be preserved as much as possible in clinical practice.",
        "keywords": [
            "applied anatomy",
            "Lisfranc injury",
            "the fourth and fifth tarsometatarsal joints"
        ],
        "authors": [
            {
                "name": "HU Sun-jun",
                "org": "Dept.of Orthopaedics,People's Hospital of Putuo District,Shanghai ,China"
            },
            {
                "name": "YU Guang-rong",
                "org": "Dept.of Orthopaedics,Tongji Hospital,Tongji University,Shanghai ,China"
            },
            {
                "name": "CHEN Jian",
                "org": "Dept.of Orthopaedics,People's Hospital of Putuo District,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Dept.of Orthopaedics,People's Hospital of Putuo District,Shanghai ,China"
            }
        ],
        "venue": "Journal of Tongji University(Medical Science)",
        "year": 2009
    },
    "uXFXI8UG": {
        "id": "uXFXI8UG",
        "title": "Delay open reduction and internal plate fixation for Ruedi-Allgower\u2161\u3001\u2162 of the Pilon tibial fracture",
        "abstract": "Objective To evaluate the feasibility of treating Ruedi-Allgower\u2161\u3001\u2162 of the Pilon tibial fracture by Delay open reduction and internal plate fixation. Methods Since 1999 to 2004,after 10 \uff5e 18 (average 15) days calcaneus-traction,24 patients of the Pilon tibial fracture (Ruedi-Allgower\u2161 11 cases,Ruedi-Allgower \u2162 13 cases) were treated by open reduction,bone grafting and internal anatomical plate fixation. Results 24 cases were followed up for 28 months on average. Delayed union in 3 cases,deforming union in 2 case,posttraumatic arthritis in 5 cases. According to Helfet criterion,the results were excellent in 8 cases,good in 10 cases,poor in 6 cases. Conclusion The method of delay open reduction and internal plate fixation reduceds the injured degree of soft tissue and provides rigid stability to early articular moving. It is a available method to treat Ruedi-Allgower\u2161\u3001\u2162 of the Pilon tibial fracture",
        "keywords": [
            "Tibial",
            "Fracture fixation",
            "Pilon",
            "fracture",
            "internal"
        ],
        "authors": [
            {
                "name": "Chen Jie",
                "org": " et al. The Putuo district renmin hospital of shanghai,department of orthpeadical. "
            },
            {
                "name": "Chen Jian",
                "org": " et al. The Putuo district renmin hospital of shanghai,department of orthpeadical. "
            },
            {
                "name": "Yu Kaile",
                "org": " et al. The Putuo district renmin hospital of shanghai,department of orthpeadical. "
            }
        ],
        "venue": "Orthopaedic Biomechanics Materials and Clinical Study",
        "year": 2007
    },
    "oZNQUofP": {
        "id": "oZNQUofP",
        "title": "Femoral subtrochanteric fractures treated with proximal lateral femur locking plate",
        "abstract": "Objective To study the outcome of subtrochanteric hip fractures treated by proximal lateral femur locking plate.Methods 28 elder patients with subtrochanteric hip fractures were treated with proximal lateral femur locking plate.Results All patients were followed up for 10 \uff5e 24 months.According to Harris index,there were 13 excellent cases,10 good and 5 fair.Conclusions The proximal lateral femur locking plate is the kind of stable and effective internal fixation of treating subtrochanteric hip fractures,and the clinical outcome is satisfied.",
        "keywords": [
            "femoral intertrochanteric fracture",
            "fracture fixation",
            "lateral wall locking plate",
            "internal"
        ],
        "authors": [
            {
                "name": "HU Sun-jun",
                "org": ""
            },
            {
                "name": "CHEN Jian",
                "org": ""
            },
            {
                "name": "CHEN Jie",
                "org": ""
            },
            {
                "name": "YU Guang-rong",
                "org": ""
            },
            {
                "name": "ZHANG Shi-min",
                "org": ""
            }
        ],
        "venue": "Journal of Clinical Orthopaedics",
        "year": 2012
    },
    "faAwlUCI": {
        "id": "faAwlUCI",
        "title": "Diagnosis and treatment of Morton neuroma",
        "abstract": "The diagnosis and treatment of Morton neuroma is reviewed in this paper.Intermetatarsal neuroma,often called Morton neuroma,is a commonly occurring disorder associated with symptoms of forefoot pain and paresthesias.It is a chronic compresive neuropathy believed to be caused by fibrosis of the epineural tissue.Current treatment of Morton neuromas includes nonoperative treatment,ultrasound-guided neuroma drug injections,endoscopic decompression of intermetatarsal nerve,excision of the neuroma,each way has merits and demerits,it is still controversial which is the best one.",
        "keywords": [
            "surgical treatment",
            "morton neuroma",
            "interdigital nerve",
            "diagnosis",
            "orthopaedics",
            "therapy",
            "surgery"
        ],
        "authors": [
            {
                "name": "HU Sun-jun",
                "org": ",et al.Department of Orthopaedics,People's Hospital of Putuo District,Shanghai ,China"
            },
            {
                "name": "CHEN Jian",
                "org": ",et al.Department of Orthopaedics,People's Hospital of Putuo District,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": ",et al.Department of Orthopaedics,People's Hospital of Putuo District,Shanghai ,China"
            }
        ],
        "venue": "Orthopedic Journal of China",
        "year": 2009
    },
    "rsepYKP0": {
        "id": "rsepYKP0",
        "title": "Comparative study of dynamic hip screw and proximal femoral nail antirotation for treatment of patients with femoral intertrochanteric fractures",
        "abstract": "Objective To study the significance of different internal fixations of intertrochanteric hip fractures by comparing the effects of using dynamic hip screw(DHS) and proximal femoral nail antirotation(PFNA) as implant.Methods The 65 elder patients with intertrochanteric hip fractures were followed up retrospectively.They were treated with the two kinds of operations: DHS 37 cases(group DHS),and PFNA 28 cases(group PFNA).The data of each group were collected for statistical analysis on the following aspects: operative time,blood loss,clinical healing time of fractures,intraoperative complications,functional outcome.Results Group DHS had one case implant infection,and 2 cases of screw breakage and hip varus.29 cases got excellent and good results in 1 year.The excellent and good rate was 78.4%.Group PFNA had shorter operative time and clinical healing time,lesser blood loss,better clinical outcome,with no case failure.24 cases got excellent and good results in 1 year.The excellent and good rate was 85.7%.Conclusions PFNA is the kind of stable and effective internal fixations of treating intertrochanteric hip fractures which has the advantage of stable fixation and antirotation with lesser blood loss.It is especially suitable for complex unstable intertrochanteric hip fractures.",
        "keywords": [
            "femoral intertrochanteric fracture",
            "fracture fixation",
            "dynamic hip screw",
            "proximal femoral nail antirotation",
            "internal"
        ],
        "authors": [
            {
                "name": "CHEN Jian",
                "org": "Dept of Orthopaedics,People\u2032s Hospital of Putuo District,Shanghai ,China"
            },
            {
                "name": "HU Sun-jun",
                "org": "Dept of Orthopaedics,People\u2032s Hospital of Putuo District,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Dept of Orthopaedics,People\u2032s Hospital of Putuo District,Shanghai ,China"
            },
            {
                "name": "YING Zheng-ran",
                "org": "Dept of Orthopaedics,People\u2032s Hospital of Putuo District,Shanghai ,China"
            }
        ],
        "venue": "Journal of Clinical Orthopaedics",
        "year": 2011
    },
    "VEIiGVpi": {
        "id": "VEIiGVpi",
        "title": "Operative treatment of humeral intercondylar fractures in older patients by using bilateral plates fixation",
        "abstract": "objective To explore the surgical management and its results of intercondylar fracture of humerus of the older patients through approach of osteotomy of olecranon or Bilateralis of Triceps Brachii Approach with dual medial and lateral plates.Method From January 2000 to October 2007,23 older patients of intercondylar fracture of humerus were treated surgically,and the fracture was reduced and fixed with medial and lateral steel plates.The patients were 10 males and 13 females with a mean age of 78 years(range 65~85 years),According to Riseborough and Radin classification,type \u2161 fracture was found in 6 cases,type \u2162 in 12,type IV in 5.Early rehabilitation exercises was taken.Result Twenty-three fractures were all satisfactory reduced,none had incision infection,one injuries of the ulnar nerve.All patients were followed up from 12 months to28 months (average18.5 months),of these 23 patients,all the osteotomies healed in 5 month averagely(range 4-10 months).The function of the elbow(according to Cassbaum scale)showed excellent in 8 cases,good in 10,fair in 5.The good-excellent rate Was 80%.Conclusion The technique of dual medial and lateral plates for the treat- ment intercondylar fracture of humerus of the older patients provide solid biomechanical stability witch allow early rehabilitation. Chose the appropriate surgical approach and use the MIPPO technique during the operation can prevent delay- union and nonunion, greatly improve the long-term result of the intercondylar fracture of humerus.",
        "keywords": [
            "Surgical approach",
            "Clinical effect",
            "Internal fixation",
            "Older patients",
            "Intercondylar fractures of humerus"
        ],
        "authors": [
            {
                "name": "Chen Jie",
                "org": ",et al.Department of Orthopaedic Surgery, the People\u2019s Hospital of Putuo District, Shang-hai , China"
            },
            {
                "name": "Chen Jian",
                "org": ",et al.Department of Orthopaedic Surgery, the People\u2019s Hospital of Putuo District, Shang-hai , China"
            },
            {
                "name": "Hu Sunjun",
                "org": ",et al.Department of Orthopaedic Surgery, the People\u2019s Hospital of Putuo District, Shang-hai , China"
            }
        ],
        "venue": "Orthopaedic Biomechanics Materials and Clinical Study",
        "year": 2009
    },
    "7kVUtlse": {
        "id": "7kVUtlse",
        "title": "Operation treatment for Vancouver B1 type periprosthetic femur fracture",
        "abstract": "Objective To investigate the therapeutic effects of two methods to treat Vancouver B1 type periprosthetic femur fracture with cable and plate or Shape-memory arm-encircling fixator. Methods A total of 21 Vancouver B1 type periprosthetic femur fracture were treated by one of these methods: cable and plate( 12 cases) and Shape-memory arm-encircling fixator( 9 cases). All the patients were followed up and recorded the functional recovery. Results All cases were followed up for 12 ~ 24 months,and all cases reached union. The functional recovery achieved the normal level before they injury in 12 months after the surgery. Conclusions Cable and plate and Shape-memory arm-encircling fixator are good way to treat Vancouver B1 type periprosthetic femur fracture. They can get good recovery function in the early postoperative stage.",
        "keywords": [
            "Vancouver classsfication",
            "periprosthetic fracture",
            "cable and plate",
            "arm-encircling fixator"
        ],
        "authors": [
            {
                "name": "CHEN Jian",
                "org": ""
            },
            {
                "name": "YING Zheng-ran",
                "org": ""
            },
            {
                "name": "CHEN Jie",
                "org": ""
            }
        ],
        "venue": "Journal of Clinical Orthopaedics",
        "year": 2013
    },
    "clGc2bC1": {
        "id": "clGc2bC1",
        "title": "Dioscin Alleviates Crystalline Silica-Induced Pulmonary Inflammation and Fibrosis through Promoting Alveolar Macrophage Autophagy.",
        "abstract": "Occupational exposure to crystalline silica (CS) particles leads to silicosis, which is characterized by chronic inflammation and abnormal tissue repair. Alveolar macrophages (AMs) play a crucial role in the process of silicosis. Previously, we demonstrated positive effect of dioscin on silicosis through modulating macrophage-elicited innate immune response. However, the concrete molecular mechanism remains to be discovered.  We established experimental model of silicosis with wildtype and Atg5Dppa3 mice and oral administrated dioscin daily to explore the effects of dioscin on macrophages and pulmonary fibrosis. AM cell line MH-S with Atg5 silence was used to explore specific function of dioscin on macrophage-derived inflammation and the underlying molecular mechanism.  Dioscin could promote autophagy in macrophages. Dioscin-triggered AMs autophagy limited mitochondrial reactive oxygen species (mtROS) mass stimulated by CS, reduced mitochondria-dependent apoptosis pathway activation and facilitated cell survival. Relieved oxidative stress resulted in decreased secretion of inflammatory factors and chemokines. Dioscin treatment alleviated macrophage-derived inflammation and subsequent abnormal collagen repair. All the dioscin's protective effects were diminished in Atg5Dppa3 mice.  Dioscin promoting autophagy leads to reduced CS-induced mitochondria-dependent apoptosis and cytokine production in AMs, which may provide concrete molecular mechanism for the therapy of silicosis.",
        "keywords": [
            "autophagy",
            "crystalline silica",
            "dioscin",
            "macrophage",
            "mitochondrial dysfunction"
        ],
        "authors": [
            {
                "name": "Sitong Du",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Chao Li",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Yiping Lu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Xue Lei",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Yiting Zhang",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Siyi Li",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Fangwei Liu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Ying Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Dong Weng",
                "org": "Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, PR China."
            },
            {
                "name": "Jie Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            }
        ],
        "venue": "Theranostics",
        "year": 2019
    },
    "MfPhmal9": {
        "id": "MfPhmal9",
        "title": "Developmental iodine deficiency and hypothyroidism reduce phosphorylation of calcium/calmodulin-dependent kinase II in the rat entorhinal cortex.",
        "abstract": "Iodine is essential for the synthesis of triiodothyronine (T\u2083) and thyroxine (T\u2084). Iodine deficiency leads to inadequate thyroid hormone. Hypothyroidism induced by iodine deficiency during gestation and postnatal period leads to cognitive deficits in learning and memory. However, the mechanism underlying these deficits is unclear. Calcium-dependent calmodulin kinase II (CaMKII) known as a potential memory molecule regulates important neuronal functions including learning and memory. Recent studies have shown that hypothyroidism alters phosphorylation of CaMKII in hippocampus or even in sympathetic ganglia of rats. Though the entorhinal cortex (EC) is an important functional structure within the neuronal network responsible for learning and memory, little is known about the effect of hypothyroidism on phosphorylation of CaMKII in the EC. Here, we report that iodine deficiency and propylthiouracil treatment through gestation and lactation reduce phosphorylation of CaMKII in the EC of pups. The increase of calcineurin, as well as reduction of neurogranin and calmodulin, may account for the reduced phosphorylation of CaMKII induced by developmental iodine deficiency and hypothyroidism. These findings in the EC may contribute to understanding the mechanisms that underlie impairment of learning and memory induced by developmental iodine deficiency and hypothyroidism.",
        "keywords": [
            "iodine deficiency.hypothyroidism.entorhinalcortex .camkii .calcineurin",
            "calmodulin",
            "neuronal network"
        ],
        "authors": [
            {
                "name": "Yi Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001 People\u2019s Republic of China"
            },
            {
                "name": "Yi Hou",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001 People\u2019s Republic of China"
            },
            {
                "name": "Jing Dong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001 People\u2019s Republic of China"
            },
            {
                "name": "Hongde Xu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001 People\u2019s Republic of China"
            },
            {
                "name": "Jian Gong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001 People\u2019s Republic of China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001 People\u2019s Republic of China"
            }
        ],
        "venue": "Biological trace element research",
        "year": 2010
    },
    "sJvJQeU6": {
        "id": "sJvJQeU6",
        "title": "Blockade of Wnt/\u03b2-Catenin Pathway Aggravated Silica-Induced Lung Inflammation through Tregs Regulation on Th Immune Responses.",
        "abstract": "CD4(+) T cells play an important role in regulating silica-induced inflammation and fibrosis. Recent studies showed that Wnt/\u03b2-catenin pathway could modulate the function and the differentiation of CD4(+) T cells. Therefore, Wnt/\u03b2-catenin pathway may participate in the development and progress of silicosis. To investigate the role of Wnt/\u03b2-catenin pathway, we used lentivirus expressing \u03b2-catenin shRNA to block the Wnt/\u03b2-catenin pathway by intratracheal instillation to the mice model of silicosis. Treatment of lentivirus could significantly aggravate the silica-induced lung inflammation and attenuated the fibrosis at the late stage. By analyzing CD4(+) T cells, we found that blockade of Wnt/\u03b2-catenin pathway suppressed regulatory T cells (Tregs). Reciprocally, enhanced Th17 response was responsible for the further accumulation of neutrophils and production of proinflammatory cytokines. In addition, blockade of Wnt/\u03b2-catenin pathway delayed the Th1/Th2 polarization by inhibiting Tregs and Th2 response. These results indicated that Wnt/\u03b2-catenin pathway could regulate Tregs to modulate Th immune response, which finally altered the pathological character of silicosis. Our study suggested that Wnt/\u03b2-catenin pathway might be a potential target to treat the silica-induced inflammation and fibrosis.",
        "keywords": "",
        "authors": [
            {
                "name": "Wujing Dai",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China."
            },
            {
                "name": "Fangwei Liu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China."
            },
            {
                "name": "Chao Li",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China."
            },
            {
                "name": "Yiping Lu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China."
            },
            {
                "name": "Xiaowei Lu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China."
            },
            {
                "name": "Sitong Du",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China."
            },
            {
                "name": "Ying Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China."
            },
            {
                "name": "Dong Weng",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China."
            },
            {
                "name": "Jie Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China."
            }
        ],
        "venue": "Mediators of inflammation",
        "year": 2016
    },
    "nynCDRsT": {
        "id": "nynCDRsT",
        "title": "Investigation of intelligence quotient,psychomotor development,and subclinical impairment in schoolchildren from areas with various degrees of iodine deficiency",
        "abstract": "Objective:To evaluate the intelligence quotient(IQ),psychomotor development,and epidemic intensity of subclinical impairment in schoolchildren form areas with various degrees of iodine deficiency(ID) after implementing Universal Salt Iodization(USI).Methods:The IQ was measured by combined raven's test in China(CRT-C2).The Psychomotor development,hearing,bone age,and somatic retardation were determined by Jinyi Psychomotor Test Battery(JPB),audiometer,radiograph,and standard physical measure,respectively.Results:The IQs of children from severe,moderate,and mild ID areas were 103.16\u00b116.64,99.70\u00b116.19,and 107.82\u00b111.83,respectively,and the IQs of children from severe or moderate ID area were significantly higher than those of children from mild ID area.The total T scores of JPB of children from severe and moderate ID areas were 316.17\u00b142.26 and 330.46\u00b147.66,both of which were lower than that of children from mild ID area(341.75\u00b148.11).The incidences of subclinical cretinism of children from severe,moderate and mild ID areas were 29.96%,32.88%,and 20.31%,respectively.Conclusion:The IQ and psychomotor development of children from severe and moderate ID areas are worse than those of children from mild ID area.The implementation of USI should be further strengthened.",
        "keywords": [
            "subclinical impairment",
            "intelligence quotient",
            "psychomotor",
            "iodine deficiency"
        ],
        "authors": [
            {
                "name": "TANG Zhi-feng",
                "org": "College of Public Health,China Medical University,Shenyang ,China"
            },
            {
                "name": "LIU Wan-yang",
                "org": "College of Public Health,China Medical University,Shenyang ,China"
            },
            {
                "name": "DONG Jing",
                "org": "College of Public Health,China Medical University,Shenyang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Public Health,China Medical University,Shenyang ,China"
            }
        ],
        "venue": "Journal of China Medical University",
        "year": 2007
    },
    "sn2Hvchl": {
        "id": "sn2Hvchl",
        "title": "Cost-Effectiveness of Coal Workers' Pneumoconiosis Prevention Based on Its Predicted Incidence within the Datong Coal Mine Group in China",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "fuhai shen",
                "org": "china medical university"
            },
            {
                "name": "hongbo liu",
                "org": "china medical university"
            },
            {
                "name": "juxiang yuan",
                "org": ""
            },
            {
                "name": "bing han",
                "org": "china medical university"
            },
            {
                "name": "kai cui",
                "org": "china medical university"
            },
            {
                "name": "yu ding",
                "org": ""
            },
            {
                "name": "xueyun fan",
                "org": ""
            },
            {
                "name": "hong cao",
                "org": ""
            },
            {
                "name": "sanqiao yao",
                "org": ""
            },
            {
                "name": "xia suo",
                "org": ""
            },
            {
                "name": "zhiqian sun",
                "org": ""
            },
            {
                "name": "xiang yun",
                "org": ""
            },
            {
                "name": "zhengbing hua",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": "china medical university"
            }
        ],
        "venue": "PLOS ONE",
        "year": 2015
    },
    "IyYV4bI8": {
        "id": "IyYV4bI8",
        "title": "Developmental hypothyroxinaemia induced by maternal mild iodine deficiency delays hippocampal axonal growth in the rat offspring.",
        "abstract": "Iodine is essential for the biosynthesis of thyroid hormones, including triiodothyronine and thyroxine. Thyroid hormones are important for central nervous system development. Mild maternal iodine deficiency (ID)-induced hypothyroxinaemia causes neurological deficits and mental retardation of the foetus. However, the detailed mechanism underlying these deficits is still largely unknown. Given that the growth-associated protein of 43 kDa (GAP-43), semaphorin 3A (Sema3A) and the glycogen synthase kinase 3\u03b2 (GSK3\u03b2)/collapsin response mediator protein 2 (CRMP2) pathway are essential for axonal development, we hypothesise that hippocampal axonal growth-related proteins may be impaired, which may contribute to hippocampal axonal growth delay in rat offspring exposed to maternal hypothyroxinaemia. To test this hypothesis, maternal hypothyroxinaemia models were established in Wistar rats using a mild ID diet. Besides a negative control group, two maternal hypothyroidism models were created with either a severe ID diet or methimazole in the water. Our results showed that maternal hypothyroxinaemia exposure delayed offspring axonal growth on gestational day 19, postnatal day (PN) 7, PN14 and PN21. Consistent with this, the mean intensity of hippocampal CRMP2 and Tau1 immunofluorescence axonal protein was reduced in the mild ID group. Moreover, maternal hypothyroxinaemia disrupted expressions of GAP-43 and Sema3A. Furthermore, the phosphorylation of GSK3\u03b2 and CRMP2 was also affected in the treated offspring, implying a potential mechanism by which hypothyroxinaemia-exposure affects neurodevelopment. Taken together, our data support the hypothesis that maternal hypothyroxinaemia may impair axonal growth of the offspring.",
        "keywords": [
            "hypothyroidism",
            "hippocampus",
            "axon",
            "hypothyroxinaemia",
            "iodine deficiency"
        ],
        "authors": [
            {
                "name": "W Wei",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Y Wang",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Y Wang",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "J Dong",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "H Min",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "B Song",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "W Teng",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Q Xi",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "J Chen",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            }
        ],
        "venue": "Journal of neuroendocrinology",
        "year": 2013
    },
    "jLEWkGwh": {
        "id": "jLEWkGwh",
        "title": "A TSP-1 synthetic peptide inhibits bleomycin-induced lung fibrosis in mice.",
        "abstract": "Bleomycin showed toxicity to lung and was recognized to induce a well model of lung fibrosis. Activated alveolar macrophages released increased amounts of transforming growth factor-beta1(TGF-beta1) in response to bleomycin-induced lung injury. Thrombospondin-1(TSP-1) was involved in the activation of latent TGF-beta1(L-TGF-beta1) through the association of the TSP-1/L-TGF-beta1 complex with the cell receptor of TSP-1, CD36. The antagonistic effects of the synthetic peptides were studied by the administration of TSP-1 (447-452) synthetic peptides to the mouse model. The hydroxyproline contents of the TSP-1-treated groups were significantly lower than those of other experimental groups. Inflammation, fibrotic degree and distribution of collagen fibers in the interstitial and alveolar in the TSP-1-treated groups were less than those of the other experimental groups. The expressions of collagen I and III in TSP-1-treated groups were significantly lower than in the other experimental groups. TSP-1 synthetic peptide reduced the tissue fibrotic pathologies and collagen accumulation in the model, resulting in the decreased severity of bleomycin-induced lung injury.",
        "keywords": [
            "latent tgf-\u03b21",
            "lung fibrosis",
            "activation",
            "bleomycin",
            "thrombospondin-1 synthetic peptide",
            "transforming growth factor"
        ],
        "authors": [
            {
                "name": "Ying Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang 110001, PR China"
            },
            {
                "name": "Xin Wang",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang 110001, PR China"
            },
            {
                "name": "Dong Weng",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang 110001, PR China"
            },
            {
                "name": "Lujia Tian",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang 110001, PR China"
            },
            {
                "name": "Lina Lv",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang 110001, PR China"
            },
            {
                "name": "Shasha Tao",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang 110001, PR China"
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Experimental and toxicologic pathology : official journal of the Gesellschaft f\u00fcr Toxikologische Pathologie",
        "year": 2009
    },
    "x8Yrtdul": {
        "id": "x8Yrtdul",
        "title": "Hypothyroidism following developmental iodine deficiency reduces hippocampal neurogranin, CaMK II and calmodulin and elevates calcineurin in lactational rats.",
        "abstract": "Developmental iodine deficiency (ID) leads to inadequate thyroid hormone that impairs learning and memory with an unclear mechanism. Here, we show that hippocampal neurogranin, calcium/calmodulin dependent protein kinase II (CaMKII), calmodulin (CaM) and calcineurin (CaN) are implicated in the brain impairment in lactational rat hippocampus following developmental ID and hypothyroidism. Three developmental rat models were created by administrating dam rats with either iodine-deficient diet or propylthiouracil (PTU, 5 ppm or 15 ppm)-added drinking water from gestational day (GD) 6 till postnatal day (PN) 21. Then, the neurogranin, CaMKII, CaM and CaN in the hippocampus were detected with immunohistochemistry and western blotting on PN14 and PN21. The iodine-deficient and hypothyroid pups showed significantly lower level of neurogranin, CaMKII and CaM and significantly increased CaN in hippocampal CA1 and CA3 regions than the controls on PN14 and PN21 (P<0.05, respectively). Data indicate that, in lactational rats, hippocampal neurogranin, CaMKII, CaM and CaN are involved in the brain impairment by developmental ID and hypothyroidism.",
        "keywords": [
            "hypothyroidism",
            "camkii",
            "calmodulin",
            "iodine deficiency",
            "neurogranin",
            "calcineurin",
            "protein kinase",
            "immunohistochemistry"
        ],
        "authors": [
            {
                "name": "Jing Dong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China"
            },
            {
                "name": "Wanyang Liu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China"
            },
            {
                "name": "Yi Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China"
            },
            {
                "name": "Qi Xi",
                "org": "Department of Physiology, The University of Tennessee Health Science Center, Room 305, Nash Building 894 Union Avenue Memphis, TN 38163, United States"
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience",
        "year": 2010
    },
    "woWq5cF6": {
        "id": "woWq5cF6",
        "title": "Maternal marginal iodine deficiency limits dendritic growth of cerebellar purkinje cells in rat offspring by NF-\u03baB signaling and MAP1B.",
        "abstract": "Iodine deficiency (ID) during early pregnancy had an adverse effect on children's psychomotor and motor function. It is worth noting that maternal marginal ID tends to be a common public health problem. Whether marginal ID potentially had adverse effects on the development of cerebellum and the underlying mechanisms remain unclear. Therefore, our aim was to study the effects of marginal ID on the dendritic growth in filial cerebellar Purkinje cells (PCs) and the underlying mechanism. In the present study, we established Wistar rat models by feeding dam rats with a diet deficient in iodine and deionized water supplemented with potassium iodide. We examined the total dendritic length using immunofluorescence, and Western blot analysis was conducted to investigate the activity of nuclear factor-\u03baB (NF-\u03baB) signaling and microtubule-associated protein 1B (MAP1B). Our results showed that marginal ID reduced the total dendritic length of cerebellar PCs, slightly down-regulated the activity of NF-\u03baB signaling and decreased MAP1B in cerebellar PCs on postnatal day (PN) 7, PN14, and PN21. Our study may support the hypothesis that decreased T induced by marginal ID limits PCs dendritic growth, which may involve in the disturbance of NF-\u03baB signaling and MAP1B on the cerebellum. \u00a9 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1241-1251, 2017.",
        "keywords": [
            "MAP1B",
            "NF-\u03baB signaling",
            "cerebellum",
            "dendrite",
            "marginal iodine deficiency",
            "purkinje cells"
        ],
        "authors": [
            {
                "name": "Ye Yu",
                "org": "Department of Occupational and Environmental Health School of Public Health, China Medical University, Shenyang, People's Republic of China."
            },
            {
                "name": "Jing Dong",
                "org": "Department of Occupational and Environmental Health School of Public Health, China Medical University, Shenyang, People's Republic of China."
            },
            {
                "name": "Yuan Wang",
                "org": "Department of Occupational and Environmental Health School of Public Health, China Medical University, Shenyang, People's Republic of China."
            },
            {
                "name": "Yi Wang",
                "org": "Department of Occupational and Environmental Health School of Public Health, China Medical University, Shenyang, People's Republic of China."
            },
            {
                "name": "Hui Min",
                "org": "Department of Occupational and Environmental Health School of Public Health, China Medical University, Shenyang, People's Republic of China."
            },
            {
                "name": "Zhongyan Shan",
                "org": "Department of Endocrinology and Metabolism, Liaoning Provincial Key Laboratory of Endocrine Diseases, the First Hospital of China Medical University, Shenyang, People's Republic of China."
            },
            {
                "name": "Weiping Teng",
                "org": "Department of Endocrinology and Metabolism, Liaoning Provincial Key Laboratory of Endocrine Diseases, the First Hospital of China Medical University, Shenyang, People's Republic of China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Occupational and Environmental Health School of Public Health, China Medical University, Shenyang, People's Republic of China."
            }
        ],
        "venue": "Environmental toxicology",
        "year": 2017
    },
    "2EFpbMI8": {
        "id": "2EFpbMI8",
        "title": "Role of IL-10-producing regulatory B cells in modulating T-helper cell immune responses during silica-induced lung inflammation and fibrosis",
        "abstract": "A Nature Research Journal",
        "keywords": "",
        "authors": [
            {
                "name": "Fangwei Liu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, P. R. China"
            },
            {
                "name": "Wujing Dai",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, P. R. China"
            },
            {
                "name": "Chao Li",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, P. R. China"
            },
            {
                "name": "Xiaowei Lu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, P. R. China"
            },
            {
                "name": "Ying Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, P. R. China"
            },
            {
                "name": "Jie Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, P. R. China"
            },
            {
                "name": "Dong Weng",
                "org": "Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, P. R. China"
            }
        ],
        "venue": "Scientific Reports",
        "year": 2016
    },
    "kTxahyMb": {
        "id": "kTxahyMb",
        "title": "Prevalence characteristics and prediction of coal workers' pneumoconiosis in the Tiefa Colliery in China.",
        "abstract": "To explore characteristics of the development of coal workers' pneumoconiosis (CWP) at present and trend in the future, we investigated 16,154 coal miners exposed to dust for at least 1 yr in the Tiefa Colliery in China. Occupational categories were divided into tunneling, mining, combining and helping. Four cohorts (before 1958, 1958-, 1968-, and after 1978) were created according to years of first exposure. Life-Table Method was used to calculate cumulative incidence rates of CWP adjusted by duration of dust exposure and predict the number of the new CWP patients. Results indicated that cumulative incidence rates of CWP in four cohorts were 26.65%, 18.94%, 1.15%, and 0.06%, respectively (Chi(2)=493.57, p<0.0001). The 55-yr cumulative rate of CWP of tunneling miners (25.90%) or that of combining miners (14.53%) was statistically higher than that of mining miners (7.26%) or that of helping miners (0.89%). The number of new CWP patients predicted in future was approximately 77. New CWP patients predicted would mainly occur among coal miners with first dust exposure in 1958-1967 and those working at tunneling. Most of them could be diagnosed in the age group from 45 to 75 and in the period of the next 20 yr from 2008 to 2028.",
        "keywords": [
            "coal workers' pneumoconiosis",
            "life-table method",
            "prediction",
            "prevalence",
            "disease prevalence",
            "disease incidence",
            "epidemiology",
            "coal miners"
        ],
        "authors": [
            {
                "name": "Hongbo Liu",
                "org": ""
            },
            {
                "name": "Zhifeng Tang",
                "org": ""
            },
            {
                "name": "Dong Weng",
                "org": ""
            },
            {
                "name": "Yongli Yang",
                "org": ""
            },
            {
                "name": "Lujia Tian",
                "org": ""
            },
            {
                "name": "Zhiwen Duan",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Industrial health",
        "year": 2009
    },
    "dCzIYSmJ": {
        "id": "dCzIYSmJ",
        "title": "Reduction of IL-17A might suppress the Th1 response and promote the Th2 response by boosting the function of Treg cells during silica-induced inflammatory response in vitro.",
        "abstract": "Silica inhalation can induce chronic lung inflammation and fibrosis. Upon silica stimulation, activated macrophages trigger the T-lymphocyte which can differentiate into many different types of Th cells, including the recently discovered Th17 cells. IL-17A, the typical Th17 cytokine, is reported in some inflammatory diseases. However, the role of IL-17A in silica-induced inflammatory response is still not clear. The regulatory mechanism of silica-induced Th17 response also needs to be investigated. So we established a mice primary cell coculture system (macrophage and lymphocyte) to investigate the role of IL-17A in silica-induced inflammatory response in vitro, by using anti-IL-17A mAb and IL-1Ra. Both anti-IL-17A mAb and IL-1Ra decreased the level of IL-17A and increased the function of Treg cells. The Th1 response was suppressed and the Th2 response was promoted by the addition of anti-IL-17A mAb or IL-1Ra. IL-1Ra treatment decreased the level of IL-6, whereas the levels of IL-23 and ROR- \u03b3 t were increased. Our study demonstrated that IL-17A reduction altered the pattern of silica-induced Th responses by boosting the function of Treg cells in vitro. Blocking the function of IL-1 signal pathway could suppress the level of IL-17A, which played the major role in modulating silica-induced Th responses in vitro.",
        "keywords": [
            "cell differentiation",
            "signal transduction",
            "gene expression regulation",
            "interleukin 23",
            "interleukin 17"
        ],
        "authors": [
            {
                "name": "Wen Tang",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Fangwei Liu",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Ying Chen",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Laiyu Song",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Wujing Dai",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Chao Li",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Dong Weng",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Jie Chen",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            }
        ],
        "venue": "Mediators of inflammation",
        "year": 2014
    },
    "8xEvtdOU": {
        "id": "8xEvtdOU",
        "title": "Maternal iodine supplementation improves motor coordination in offspring by modulating the mGluR1 signaling pathway in mild iodine deficiency-induced hypothyroxinemia rats.",
        "abstract": "Iodine is an essential component for thyroid hormone synthesis. Epidemiological investigations have demonstrated that maternal mild iodine deficiency (ID)-induced hypothyroxinemia can affect intellectual and behavioral function in offspring. There is no definitive evidence demonstrating the effects of maternal iodine supplementation on neurobehavioral function in regional areas with mild ID. Thus, we aimed to clarify the effects of maternal mild ID and iodine supplementation on motor coordination in offspring and illuminate the underlying molecular mechanisms. Animal models of maternal mild ID and iodine supplementation were generated by providing Wistar rats an iodine-deficient diet and deionized water supplemented with potassium iodide during pregnancy and lactation. We found that mild ID-induced hypothyroxinemia led to a shorter latent time before falling down from the rotarod, a longer time to traverse the balance beam and poorer wire grip of the forelimbs, which imply motor coordination dysfunction. However, these impairments in the offspring were improved by iodine supplementation during pregnancy and lactation. We further observed that the ultrastructure and dendritic tree morphology of cerebellar Purkinje cells were altered in mild ID-induced hypothyroxinemia but that these changes could be reversed by iodine supplementation. Maternal mild ID and iodine supplementation also affected expression of the mGluR1 signaling pathway in offspring. Together, iodine supplementation during pregnancy and lactation can improve motor coordination in offspring by modulating the mGluR1 signaling pathway in mild ID-induced hypothyroxinemia rats.",
        "keywords": [
            "Hypothyroxinemia",
            "Iodine supplementation",
            "Mild iodine deficiency",
            "Motor coordination",
            "Purkinje cells",
            "mGluR1 signaling"
        ],
        "authors": [
            {
                "name": "Yuan Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Jun Han",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Xi Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Xinning Zeng",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Yi Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Jing Dong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China. Electronic address: jchen@cmu.edu.cn."
            }
        ],
        "venue": "The Journal of nutritional biochemistry",
        "year": 2018
    },
    "HoLpeVOH": {
        "id": "HoLpeVOH",
        "title": "Silencing CD36 gene expression results in the inhibition of latent-TGF-\u03b21 activation and suppression of silica-induced lung fibrosis in the rat",
        "abstract": "BACKGROUND: The biologically active form of transforming growth factor-\u03b21 (TGF-\u03b21) plays a key role in the development of lung fibrosis. CD36 is involved in the transformation of latent TGF-\u03b21 (L-TGF-\u03b21) to active TGF-\u03b21. To clarify the role of CD36 in the development of silica-induced lung fibrosis, a rat silicosis model was used to observe both the inhibition of L-TGF-\u03b21 activation and the antifibrotic effect obtained by lentiviral vector silencing of CD36 expression. METHODS: The rat silicosis model was induced by intratracheal injection of 10 mg silica per rat and CD36 expression was silenced by administration of a lentiviral vector (Lv-shCD36). The inhibition of L-TGF-\u03b21 activation was examined using a CCL-64 mink lung epithelial growth inhibition assay, while determination of hydroxyproline content along with pathological and immunohistochemical examinations were used for observation of the inhibition of silica-induced lung fibrosis. RESULTS: The lentiviral vector (Lv-shCD36) silenced expression of CD36 in alveolar macrophages (AMs) obtained from bronchoalveolar lavage fluid (BALF) and the activation of L-TGF-\u03b21 in the BALF was inhibited by Lv-shCD36. The hydroxyproline content of silica+Lv-shCD36 treated groups was significantly lower than in other experimental groups. The degree of fibrosis in the silica+Lv-shCD36-treated groups was less than observed in other experimental groups. The expression of collagen I and III in the silica+Lv-shCD36-treated group was significantly lower than in the other experimental groups. CONCLUSION: These results indicate that silencing expression of CD36 can result in the inhibition of L-TGF-\u03b21 activation in a rat silicosis model, thus further preventing the development of silica-induced lung fibrosis.",
        "keywords": [
            "gene expression",
            "transforming growth factor",
            "biological activity"
        ],
        "authors": [
            {
                "name": "Xin Wang",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China"
            },
            {
                "name": "Ying Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China"
            },
            {
                "name": "Lina Lv",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China"
            },
            {
                "name": "Jie Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China"
            }
        ],
        "venue": "Respiratory Research",
        "year": 2009
    },
    "JtecFIPk": {
        "id": "JtecFIPk",
        "title": "Effect of iodine deficiency and hypothyroidism on the protein expressions of ERK1/2 in the hippocampus of rat pups]",
        "abstract": "To observe the effect of iodine deficiency and hypothyroidism on the expression of extracellular signal-regulated protein kinase 1/2 (ERK1/2) in the hippocampus of rat pups.Pregnant Wistar rats (n=28) were randomly divided into control group, hypothyroid group (containing PTU 5 mg/L and 15 mg/L in drinking water) and iodine deficient group. The brains of 5 pups from each group were fixed by intracardiac perfusion at 7, 14, 21, 28 and 42 days after birth. Brain sections were observed and analyzed by immunohistochemistry on the expression of ERK1/2 in the CA1, CA3 and DG regions of hippocampus.The expressions of ERKl/2 in CA1 and CA3 regions of hippocampus in iodine-deficient group, PTU 5 mg/L group and PTU 15 mg/L group were significantly lower than those in control group (P < 0.05) at 14, 21, 28 and 42 days after birth. The expression of ERK1/2 in DG region was not significantly different in all four groups. The expressions of ERK1/2 were not significantly different in all four groups at 7 days after birth.Iodine deficiency and hypothyroidism may decrease the expression of ERK1/2 in the hippocampus of pups.",
        "keywords": [
            "extracellular signal-regulated protein kinase(erk)1 /2",
            "hypothyroidism",
            "hippocampus",
            "iodine deficiency"
        ],
        "authors": [
            {
                "name": "Wanyang Liu",
                "org": " Department of Occupational and Environmental Health,School of Public Health,China Medical University,Shenyang ,China"
            },
            {
                "name": "Yi Wang",
                "org": " Department of Occupational and Environmental Health,School of Public Health,China Medical University,Shenyang ,China"
            },
            {
                "name": "Jing Dong",
                "org": " Department of Occupational and Environmental Health,School of Public Health,China Medical University,Shenyang ,China"
            },
            {
                "name": "Wei Wei",
                "org": " Department of Occupational and Environmental Health,School of Public Health,China Medical University,Shenyang ,China"
            },
            {
                "name": "Jie Chen",
                "org": " Department of Occupational and Environmental Health,School of Public Health,China Medical University,Shenyang ,China"
            }
        ],
        "venue": "Wei sheng yan jiu = Journal of hygiene research",
        "year": 2010
    },
    "PcnrCq2l": {
        "id": "PcnrCq2l",
        "title": "Effects of cerebellar development and the expression of CaMK\u2161 in the cerebellum of iodine deficient and hypothyroid pup rats",
        "abstract": "Objective We have tested whether congenital iodine deficiency and hypothyroidism could regulate expression of CaMK\u2161in pup cerebellum cortex,and impair functional lesion in pup cerebellum.Methods Female Wistar rats(n=28) after pregnancy were randomly divided into four groups: control group,iodine deficient group,hypothyroid-1 group(5 ppm) and hypothyroid-2 group(15 ppm).The control group was fed a normal diet during the experiment.The iodine deficient group was fed an iodine-deficient diet.The hypothyroid-1 group was fed a normal diet and had 5 ppm PTU-added water and the hypothyroid-2 group had 15 ppm PTU-added water.All the groups were from GD6 through to postnatal day(PN) 28.On PN7,PN14,PN21,PN28,pups in each group the part of the cerebellum were separated from the brain for protein detection by Nissl's staining and CaMK\u2161immunohistochemistry.Results On PN14,PN21,PN28 and PN42,Nissl's body expression in 5 ppm,15 ppm and iodine-deficient groups were significantly lower than those of controls(P<0.05);CaMK\u2161expression in 15 ppm and iodine-deficient groups were significantly lower than those of controls(P<0.05).Conclusion Iodine deficiency and hypothyroidism during a period of brain development changed cerebellar morphology and affected the expression of CaMK\u2161.The changes could impair synaptic plasticity,affect the formation of normal neural circuit,and resulted in cerebellar development disturbance.",
        "keywords": [
            "CaMK\u2161",
            "Iodine deficiency",
            "Cerebellum",
            "Hypothyroidism",
            "Nissl's body"
        ],
        "authors": [
            {
                "name": "SHAN Liang",
                "org": " Department of Occupational Health and Environmental Health,School of Public Health, China Medical University,Shenyang ,China"
            },
            {
                "name": "DONG Jing",
                "org": " Department of Occupational Health and Environmental Health,School of Public Health, China Medical University,Shenyang ,China"
            },
            {
                "name": "WANG Yi",
                "org": " Department of Occupational Health and Environmental Health,School of Public Health, China Medical University,Shenyang ,China"
            },
            {
                "name": "GONG Jian",
                "org": " Department of Occupational Health and Environmental Health,School of Public Health, China Medical University,Shenyang ,China"
            },
            {
                "name": "LI Jin-yan",
                "org": " Department of Occupational Health and Environmental Health,School of Public Health, China Medical University,Shenyang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": " Department of Occupational Health and Environmental Health,School of Public Health, China Medical University,Shenyang ,China"
            }
        ],
        "venue": "Chinese Journal of Control of Endemic Diseases",
        "year": 2012
    },
    "rvz2xJVe": {
        "id": "rvz2xJVe",
        "title": "Maternal exposure to environmental DEHP exacerbated OVA-induced asthmatic responses in rat offspring.",
        "abstract": "Di (ethylhexyl) phthalate (DEHP) is a commonly used phthalates (PAEs) compound as plasticizer and becomes a severe environmental pollutant worldwide. Studies show that DEHP, as an environmental endocrine disruptor, has potential adverse effects on human. Epidemiologic studies indicate that DEHP is positively correlated to allergic diseases. Maternal exposure to DEHP may contribute to the increasing incidence of allergic diseases in offspring. However, the role of DEHP and its detailed mechanism in allergic disease of the offspring are still unclear. The aim of our study is to investigate whether DEHP maternal exposure could aggravate the allergic responses in offspring and its mechanism. Pregnant Wistar rats were randomly divided into three groups and exposed to different doses of DEHP. Half of the offspring were challenged with OVA after birth. All the pups of each group were sacrificed at postnatal day (PND)14, PND21 and PND28. The number of inflammatory cells in bronchoalveolar lavage was counted, lung pathological changes were observed, Th2 type cytokines expressions were checked, and the expression of TSLP signaling pathway were examined. Our results showed that maternal exposure to DEHP during pregnancy and lactation aggravated the eosinophils accumulation and the pathological inflammatory changes in pups' lung after OVA challenge. And maternal exposure to DEHP during pregnancy and lactation also elevated the levels of typical Th2 cytokines in OVA-challenged rats. What's more, maternal exposure to DEHP during pregnancy and lactation increased the levels of TSLP, TSLPR and IL-7R in the offspring after OVA challenge. Our study suggested that DEHP maternal exposure could aggravate the OVA-induced asthmatic responses in offspring. And this adjuvant effect of DEHP was related with the TSLP/TSLPR/IL-7R and its downstream signal pathways.",
        "keywords": [
            "DEHP",
            "Maternal exposure",
            "TSLP",
            "Th2 response"
        ],
        "authors": [
            {
                "name": "Bohan Wang",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Fangwei Liu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Jing Dong",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Mingdan You",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Yuanyuan Fu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Chao Li",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Yiping Lu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Jie Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            }
        ],
        "venue": "The Science of the total environment",
        "year": 2017
    },
    "NoYRUHOy": {
        "id": "NoYRUHOy",
        "title": "Environmental mycological study and allergic respiratory disease among tobacco processing workers.",
        "abstract": "This study presents the results of an investigation of respiratory symptoms, lung function, chest X-ray examinations, analysis of specific IgE antibodies and skin prick tests to fungi on 130 tobacco-processing workers and 112 control workers. Industrial hygiene survey and environmental mycological studies were also performed. The average dust concentrations ranged from 13.76 to 29.55 mg/m(3) in the tobacco processing workshops. Also, the numbers of fungi colonies in the processing environments were much higher than those in the control environments. The prevalences of chronic respiratory or nasal symptoms in exposed workers were significantly higher than those in control workers (p<0.05 or p<0.01). The prevalences of lung function abnormalities in the exposed workers were significantly higher than those in control workers (p<0.05). The positive prevalences of specific IgE reactions to fungi (26.92% for A.fumigatus and 51.54% for Rhizopus nigricans) in exposed workers were also significantly higher than those in control workers (p<0.01). The positive prevalences of the skin prick test showed that 18.46% of the exposed workers were positive to A. fumigatus and 23.85% were positive to Rhizopus nigricans. Our results suggested that tobacco processing workers may develop respiratory diseases related to tobacco dust and we consider that fungi might be one of the allergens causing allergic respiratory or nasal diseases in tobacco processing workers.",
        "keywords": [
            "lung function",
            "respiratory symptom",
            "tobacco dust",
            "skin prick test",
            "specific ige to fungi"
        ],
        "authors": [
            {
                "name": "Yongxing Zhang",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Ying Chen",
                "org": ""
            },
            {
                "name": "Jing Dong",
                "org": ""
            },
            {
                "name": "Qingyu Wei",
                "org": ""
            },
            {
                "name": "Jiezhi Lou",
                "org": ""
            }
        ],
        "venue": "Journal of occupational health",
        "year": 2005
    },
    "1iThDLqi": {
        "id": "1iThDLqi",
        "title": "Iodine deficiency increases apoptosis and decreases synaptotagmin-1 and PSD-95 in rat hippocampus.",
        "abstract": "Developmental iodine deficiency (ID) leads to inadequate thyroid hormone that impairs the development of the central nervous system with an unclear mechanism. Here, we show that hippocampal apoptosis, synaptotagmin-1, and PSD-95 are involved in the synaptic impairment following developmental ID.Two developmental rat models were created by administrating dam rats with either iodine-deficient diet or propylthiouracil (PTU, 15 ppm)-added drinking water from gestational day 6 till postnatal day (PND) 28. Then, the apoptosis in the hippocampus was determined by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay, and the levels of synaptotagmin-1 and PSD-95 were detected with western blot on PND14, PND21, and PND28.The results showed that apoptosis cells and activity of caspase3 were increased in the iodine-deficient and PTU-treatment rats (P < 0.05, respectively). The iodine-deficient and PTU-treatment pups showed significantly lower level of synaptotagmin-1 and PSD-95 in hippocampus than that of controls (P < 0.05, respectively).Developmental ID resulted in the increase and delay of cell apoptosis and the decrease of synaptotagmin-1 and PSD-95 in the hippocampus, which were implicated in the impairment of brain development.",
        "keywords": [
            "hippocampus",
            "synaptotagmin-1",
            "iodine deficiency",
            "psd-95",
            "caspase3",
            "synaptotagmin 1"
        ],
        "authors": [
            {
                "name": "Jing Dong",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Yuan Wang",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Yi Wang",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Wei Wei",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Hui Min",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Binbin Song",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Qi Xi",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Weiping Teng",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Jie Chen",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            }
        ],
        "venue": "Nutritional neuroscience",
        "year": 2013
    },
    "JSUaEDuo": {
        "id": "JSUaEDuo",
        "title": "The value of high resolution computed tomography in the diagnostics of small opacities and complications of silicosis in mine machinery manufacturing workers, compared to radiography.",
        "abstract": "The purpose of this study was to assess the value and usefulness of high resolution computed tomography (HRCT) in the diagnostics of small opacities and complications of silicosis in mine machinery manufacturing workers, compared to conventional radiograms. The diagnosis of silicosis is mainly based on the radiological findings of workers exposed to the dust causing lung fibrosis. However, on radiograms many parenchymal structures overlap, which limits the sensitivity and specificity of the method. Difficulties in accurate interpretation of conventional radiograms in silicosis also result from their relatively low resolution. We randomly selected 30 I period silicosis patients from 77 I period silicosis patients working at a mine machinery manufacturing company. Out of 1078 non-silicosis and 162 0+ period silicosis subjects, 30 non-silicosis and 30 0+ period silicosis subjects were randomly selected and matched with the 30 I period silicosis subjects by age (+/- 3.0 yr) and occupational exposure time (+/- 2.0 yr). Chest X-rays were taken at maximal inspiration. For the HRCT examination, the GE Somatom plus apparatus was used. Eight, five and six subjects were respectively diagnosed as 0+, I or I+ period silicosis based on HRCT among 90 subjects whose original diagnoses were non-silicosis, 0+ or I period silicosis based on radiography. The numbers of small opacities in HRCT scans were significantly higher than those seen in radiography in all lung zones (p<0.01). HRCT was more sensitive than radiography in detecting small opacities of mid-out zones of the lung, but no statistical significance was found between the two methods in the detection of small opacities of lower zones of the lung. A statistically significant increase in the detectability of bulla, emphysema, pleural, mediastinal and hilar changes was observed (p<0.05). HRCT might be more sensitive than radiography in detecting lung parenchymal changes suggestive of silicosis.",
        "keywords": [
            "high resolution computed tomography",
            "radiography",
            "silicosis"
        ],
        "authors": [
            {
                "name": "Jinkai Sun",
                "org": ""
            },
            {
                "name": "Dong Weng",
                "org": ""
            },
            {
                "name": "Changshan Jin",
                "org": ""
            },
            {
                "name": "Bo Yan",
                "org": ""
            },
            {
                "name": "Guihua Xu",
                "org": ""
            },
            {
                "name": "Bo Jin",
                "org": ""
            },
            {
                "name": "Shenning Xia",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Journal of occupational health",
        "year": 2008
    },
    "pXoGvtLJ": {
        "id": "pXoGvtLJ",
        "title": "1,3-\u03b2-glucan affects the balance of Th1/Th2 cytokines by promoting secretion of anti-inflammatory cytokines in vitro.",
        "abstract": "1,3-\u03b2-glucan is considered a fungal biomarker and exposure to this agent induces lung inflammation. Previous studies have shown that 1,3-\u03b2-glucan affects Th1 and Th2 immune responses. Interleukin (IL)-10 and transforming growth factor (TGF)-\u03b2, as typical anti-inflammatory cytokines, suppress the Th1 immune response. To investigate the effects of 1,3-\u03b2-glucan on the secretion of cytokines in co-cultured mouse macrophages and lymphocytes in vitro, mice were exposed to 1,3-\u03b2-glucan or phosphate-buffered saline (PBS) by intratracheal instillation. Following extraction and co-culture of macrophages and lymphocytes, which were treated with or without 1,3-\u03b2-glucan in vitro, enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of cytokines and real-time reverse transcription (RT)-polymerase chain reaction (PCR) was used to investigate the mRNA expression of forkhead box p3 (Foxp3) in the cells. We showed that 1,3-\u03b2-glucan exposure in vitro decreased the secretion of Th1 cytokines and increased the secretion of Th2 cytokines in the culture media. Furthermore, 1,3-\u03b2-glucan exposure in vitro increased the secretion of IL-10 and TGF-\u03b2 in the culture media. According to these results, 1,3-\u03b2-glucan exposure in vitro is suggested to promote the secretion of anti-inflammatory cytokines, which may lead to a decrease in the levels of Th1 cytokines and an increase in the levels of Th2 cytokines. 1,3-\u03b2-glucan is suggested to induce regulatory lymphocytes, which partly contributes to an increased secretion of anti-inflammatory cytokines in co-cultured mouse macrophages and lymphocytes in vitro.",
        "keywords": [
            "1",
            "3-\u03b2-glucan",
            "anti-inflammatory cytokine",
            "th1/th2 cytokine",
            "molecular medicine",
            "oncology",
            "apoptosis",
            "cell",
            "cancer",
            "gene",
            "cell cycle"
        ],
        "authors": [
            {
                "name": "Ying Chen",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Lei Dong",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Dong Weng",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Fangwei Liu",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Laiyu Song",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Cuiying Li",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Wen Tang",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Jie Chen",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            }
        ],
        "venue": "Molecular medicine reports",
        "year": 2013
    },
    "ei99IK4O": {
        "id": "ei99IK4O",
        "title": "Establishment and application of an index system for prevention of coal workers' pneumoconiosis: a Delphi and analytic hierarchy process study in four state-owned coal enterprises of China.",
        "abstract": "The index system could be effectively used for evaluation and comparison of the comprehensive measures against CWP among different enterprises. The geological conditions and dust control engineering technology played an important role in preventing and controlling CWP.",
        "keywords": [
            "analytic hierarchy process",
            "coal workers\u2019 pneumoconiosis",
            "delphi method"
        ],
        "authors": [
            {
                "name": "Kai Cui",
                "org": "School of Public Health, Jinzhou Medical University, Jinzhou, China."
            },
            {
                "name": "Fuhai Shen",
                "org": "School of Public Health, North China University of Science and Technology, Tangshan, China."
            },
            {
                "name": "Bing Han",
                "org": "School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Hongbo Liu",
                "org": "School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Jie Chen",
                "org": "School of Public Health, China Medical University, Shenyang, China."
            }
        ],
        "venue": "Occupational and environmental medicine",
        "year": 2018
    },
    "UywR3BLu": {
        "id": "UywR3BLu",
        "title": "Developmental iodine deficiency and hypothyroidism impair neural development in rat hippocampus: involvement of doublecortin and NCAM-180.",
        "abstract": "Developmental iodine deficiency results in inadequate thyroid hormone (TH), which damages the hippocampus. Here, we explored the roles of hippocampal doublecortin and neural cell adhesion molecule (NCAM)-180 in developmental iodine deficiency and hypothyroidism.Two developmental rat models were established with either an iodine-deficient diet, or propylthiouracil (PTU)-adulterated water (5 ppm or 15 ppm) to impair thyroid function, in pregnant rats from gestational day 6 until postnatal day (PN) 28. Silver-stained neurons and protein levels of doublecortin and NCAM-180 in several hippocampal subregions were assessed on PN14, PN21, PN28, and PN42.The results show that nerve fibers in iodine-deficient and 15 ppm PTU-treated rats were injured on PN28 and PN42. Downregulation of doublecortin and upregulation of NCAM-180 were observed in iodine-deficient and 15 ppm PTU-treated rats from PN14 on. These alterations were irreversible by the restoration of serum TH concentrations on PN42.Developmental iodine deficiency and hypothyroidism impair the expression of doublecortin and NCAM-180, leading to nerve fiber malfunction and thus impairments in hippocampal development.",
        "keywords": [
            "iodine",
            "cell proliferation",
            "up regulation",
            "neurogenesis",
            "cell differentiation",
            "neural development",
            "neurosciences",
            "neural cell adhesion molecule",
            "hippocampus",
            "microtubule associated proteins",
            "neurobiology",
            "down regulation",
            "neuropeptides"
        ],
        "authors": [
            {
                "name": "Jian Gong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China"
            },
            {
                "name": "Wanyang Liu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China"
            },
            {
                "name": "Jing Dong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China"
            },
            {
                "name": "Yi Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China"
            },
            {
                "name": "Hongde Xu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China"
            },
            {
                "name": "Wei Wei",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China"
            },
            {
                "name": "Jiapeng Zhong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China"
            },
            {
                "name": "Qi Xi",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China|Department of Physiology, the University of Tennessee Health Science Center, Memphis, TN 38163, USA"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China"
            }
        ],
        "venue": "BMC neuroscience",
        "year": 2010
    },
    "yIgE20Zb": {
        "id": "yIgE20Zb",
        "title": "T reg cells may regulate interlukin-17 production by modulating T H 1 responses in 1,3- \u03b2 -glucan-induced lung inflammation in mice",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ying chen",
                "org": ""
            },
            {
                "name": "fangwei liu",
                "org": ""
            },
            {
                "name": "dong weng",
                "org": ""
            },
            {
                "name": "laiyu song",
                "org": ""
            },
            {
                "name": "cuiying li",
                "org": ""
            },
            {
                "name": "wen tang",
                "org": ""
            },
            {
                "name": "ye yu",
                "org": ""
            },
            {
                "name": "wujing dai",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            }
        ],
        "venue": "Journal of Immunotoxicology",
        "year": 2013
    },
    "HOKKo0lJ": {
        "id": "HOKKo0lJ",
        "title": "Exposure to Di-(2-ethylhexyl) Phthalate During Perinatal Period Gender-Specifically Impairs the Dendritic Growth of Pyramidal Neurons in Rat Offspring.",
        "abstract": "Di-(2-ethylhexyl) phthalate (DEHP), as a prevalent xenoestrogen endocrine disrupter, is omnipresent in the environment and commonly used in polyethylene plastic products. Although DEHP has potential adverse effects on multisystem organs, damage to the central nervous system is more significant. However, the consequences and mechanisms of DEHP exposure remain to be explored. The aim of this study was to investigate the effects and related mechanisms of maternal DEHP exposure on dendritic development of hippocampal pyramidal neurons in a rat model. Pregnant Wistar rats were intragastrically administrated either vehicle or DEHP (30, 300, and 750 mg/kg/d) from gestation day 0 to postnatal day (PN) 21. The dendritic length and complexity of dendritic arbors' pattern in pyramidal neurons of the hippocampus were measured using Golgi-Cox staining and Sholl analysis. The expression of dendritic development-related proteins was detected using western blot and immunofluorescence staining. DEHP-treated male but not female pups showed an obvious decrease in the total length and branching numbers of basal dendrites on PN7, PN14, and PN21. The phosphorylation of MAP2c, stathmin, and JNK1 in the male pup hippocampus was significantly decreased in DEHP treatment groups compared to controls. However, protein expression alteration in the hippocampus of female offspring was not observed. In summary, our study indicated that DEHP has a gender-specific negative impact on the dendritic growth of CA1 pyramidal neurons in male offspring of a rat model of DEHP exposure. The adverse impact may be related to the dysregulation of phosphorylated and total MAP2c and stathmin mediated by JNK1.",
        "keywords": [
            "DEHP",
            "dendrite",
            "endocrine-disrupting chemicals",
            "hippocampus",
            "neurotoxicity"
        ],
        "authors": [
            {
                "name": "Mingdan You",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Jing Dong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Yuanyuan Fu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Zhangzhao Cong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Hui Fu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Lingling Wei",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Yi Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Yuan Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, China."
            }
        ],
        "venue": "Frontiers in neuroscience",
        "year": 2018
    },
    "v8KoPgDd": {
        "id": "v8KoPgDd",
        "title": "A CD36 synthetic peptide inhibits silica-induced lung fibrosis in the mice.",
        "abstract": "Silicosis is a kind of pneumoconiosis caused by inhalation of silica dust, which is characterized by lung fibrosis. The biologically active form of transforming growth factor-beta1 (TGF-beta1) plays a key role in the development of lung fibrosis. CD36 is involved in the transformation of latent TGF-beta1 (L-TGF-beta1) to active TGF-beta1. The antagonistic effect of the synthetic peptide was analyzed by the administration of CD36 (93-110) synthetic peptide to the silicosis model of mice. The hydroxyproline content of the silica + CD36 (93-110) synthetic peptide group was significantly lower than that of the other experimental groups [silica and silica + CD36 (208-225) synthetic peptide groups] (p < .05). Inflammation, fibrotic degree and distribution of collagen fibers in silicotic nodules of the silica + CD36 (93-110) synthetic peptide group were less than those of the other experimental groups. The expressions of collagen I and III of the silica + CD36 (93-110) synthetic peptide group were significantly lower than those of the other experimental groups (p < .05). CD36 (93-110) synthetic peptide reduced the tissue fibrotic pathologies and collagen accumulation in the silicosis model of mice, resulting in the decreased severity of silica-induced lung fibrosis.",
        "keywords": [
            "activation",
            "cd36 synthetic peptide",
            "latent tgf-\u03b21",
            "silicosis"
        ],
        "authors": [
            {
                "name": "Xin Wang",
                "org": ""
            },
            {
                "name": "Lina Lv",
                "org": ""
            },
            {
                "name": "Ying Chen",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Toxicology and industrial health",
        "year": 2010
    },
    "VNkzVzdg": {
        "id": "VNkzVzdg",
        "title": "Effects of Maternal Marginal Iodine Deficiency on Dendritic Morphology in the Hippocampal CA1 Pyramidal Neurons in Rat Offspring.",
        "abstract": "Although the salt iodization programmes are taken to control iodine deficiency (ID), some regions are still suffering from marginal ID. During pregnancy, marginal ID frequently leads to subtle insufficiency of thyroid hormones, characterized as low serum T4 levels. Therefore, the present research was to explore the effects of maternal marginal ID exposure on dendritic arbor growth in the hippocampal CA1 region and the underlying mechanisms. We established Wistar rat models with ID diet during pregnancy and lactation. The overall daily iodine intakes of the rats were estimated as 7.0, 5.0 and 1.5 \u03bcg/day in the control, marginal ID and severe ID groups, respectively. To study the morphological alterations of pyramidal neurons, Golgi-Cox procedure was conducted in the hippocampus. Sholl analyses demonstrated a slight decrease in the total length and branching numbers of basal dendrites on postnatal day (PN) 7, PN14 and PN21 in marginal ID group relative to the controls. However, there was no overt morphological change observed in apical dendrites. Immunofluorescence and Western blot analysis indicated that phosphorylation of MAP2, stathmin and JNK1 was down-regulated in marginal ID group. We speculate that the pups treated with maternal marginal ID subjected to subtle changes in dendritic growth of CA1 pyramidal neurons, which may be associated with the dysregulation of MAP2 and stathmin in a JNK1-dependent manner.",
        "keywords": [
            "Dendritic branch",
            "Hippocampus",
            "Iodine deficiency",
            "Pyramidal neurons",
            "Thyroid hormones"
        ],
        "authors": [
            {
                "name": "Hui Min",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, People's Republic of China."
            },
            {
                "name": "Yi Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, People's Republic of China."
            },
            {
                "name": "Jing Dong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, People's Republic of China."
            },
            {
                "name": "Yuan Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, People's Republic of China."
            },
            {
                "name": "Ye Yu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, People's Republic of China."
            },
            {
                "name": "Zhongyan Shan",
                "org": "Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, People's Republic of China."
            },
            {
                "name": "Qi Xi",
                "org": "Department of Physiology, The University of Tennessee Health Science Center, Memphis, TN, 38163, USA."
            },
            {
                "name": "Weiping Teng",
                "org": "Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, People's Republic of China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, People's Republic of China. chenjie@mail.cmu.edu.cn."
            }
        ],
        "venue": "Neuromolecular medicine",
        "year": 2016
    },
    "ttccW8KO": {
        "id": "ttccW8KO",
        "title": "Physiological mechanisms underlying OsNAC5-dependent tolerance of rice plants to abiotic stress.",
        "abstract": "To understand the functions of transcription factor OsNAC5 in response to abiotic stress, we generated transgenic rice plants with knockdown OsNAC5 by RNA-interfered (RNAi) and overexpressing OsNAC5, and investigated the effects of cold, drought and salt stress on wild-type (WT), RNAi and overexpression rice lines. Our results demonstrated that RNAi lines became less tolerant to these stresses than WT plants, while overexpression of OsNAC5 in Arabidopsis and rice enhanced tolerance to these stresses. The mechanisms underlying the changes in tolerance of the transgenic rice plants to abiotic stresses were explored by measuring free proline (Pro) and soluble sugar contents in WT and transgenic plants. Accumulation of Pro and soluble sugars was positively correlated with OsNAC5 expression levels. The less accumulation of Pro in RNAi lines may be accounted for by inhibition of Pro synthesis and transport at transcriptional levels. In addition, knockdown and overexpression of OsNAC5 enhanced and reduced accumulation of malondialdehyde and H(2)O(2), suggesting that knockdown of OsNAC5 renders RNAi plants more susceptible to oxidative damage. The RNAi lines displayed higher Na(+)/K(+) ratio due to greater accumulation of Na(+) ions than WT under salt stress conditions, and expression of genes encoding tonoplast Na(+)/H(+) antiporter was lower in RNAi lines than in WT under both control and salt-stressed conditions. Seed germination of RNAi and overexpression plants was more and less inhibited by salt and mannitol than that of WT, respectively. Seed germination of overexpression and RNAi plants was more and less sensitive than that of WT to ABA. These findings highlight the important role of OsNAC5 played in the tolerance of rice plants to abiotic stress by regulating downstream targets associated with accumulation of compatible solutes, Na(+) ions, H(2)O(2) and malondialdehyde.",
        "keywords": [
            "porter was lower in rnai lines than in wt under both control and salt-stressed conditions. seed germination of rnai and overexpression plants was more and less"
        ],
        "authors": [
            {
                "name": "Shi-Yong Song",
                "org": "State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, The Chinese Academy of Sciences, Beijing, 100093 People\u2019s Republic of China"
            },
            {
                "name": "Ying Chen",
                "org": "State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, The Chinese Academy of Sciences, Beijing, 100093 People\u2019s Republic of China"
            },
            {
                "name": "Jie Chen",
                "org": "State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, The Chinese Academy of Sciences, Beijing, 100093 People\u2019s Republic of China"
            },
            {
                "name": "Xiao-Yan Dai",
                "org": "State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, The Chinese Academy of Sciences, Beijing, 100093 People\u2019s Republic of China"
            },
            {
                "name": "Wen-Hao Zhang",
                "org": "State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, The Chinese Academy of Sciences, Beijing, 100093 People\u2019s Republic of China"
            }
        ],
        "venue": "Planta",
        "year": 2011
    },
    "TzrVq2N4": {
        "id": "TzrVq2N4",
        "title": "Comparison of the Cumulative Incidence Rates of Coal Workers\u2019 Pneumoconiosis between 1970 and 2013 among Four State-Owned Colliery Groups in China",
        "abstract": "",
        "keywords": [
            "cumulative incidence rate"
        ],
        "authors": [
            {
                "name": "kai cui",
                "org": ""
            },
            {
                "name": "fuhai shen",
                "org": ""
            },
            {
                "name": "bing han",
                "org": ""
            },
            {
                "name": "juxiang yuan",
                "org": ""
            },
            {
                "name": "xia suo",
                "org": ""
            },
            {
                "name": "tianbang qin",
                "org": ""
            },
            {
                "name": "hongbo liu",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            }
        ],
        "venue": "International Journal of Environmental Research and Public Health",
        "year": 2015
    },
    "sCrTLXSi": {
        "id": "sCrTLXSi",
        "title": "Depletion of CD4+CD25+Foxp3+ regulatory T cells with anti-CD25 antibody may exacerbate the 1,3-\u03b2-glucan-induced lung inflammatory response in mice.",
        "abstract": "1,3-\u03b2-Glucan was a major cell wall component of fungus. The existing studies showed that 1,3-\u03b2-glucan exposure could induce lung inflammation that involved both Th1 and Th2 cytokines. Regulatory T cells (Treg cells) played a critical role in regulating immune homeostasis by adjusting the Th1/Th2 balance. The role of Treg cells and regulatory mechanism in 1,3-\u03b2-glucan-induced lung inflammation is still unclear. In our study, mice were exposed to 1,3-\u03b2-glucan by intratracheal instillation. To investigate the role of Treg cells in response to 1,3-\u03b2-glucan, we generated Treg-depleted mice by intraperitoneal administration of anti-CD25 mAb. The Treg-depleted mice showed more inflammatory cells and severer pathological inflammatory change in lung tissue. Depletion of Treg cells led to increased Th1 cytokines and decreased Th2 cytokines. Treg-depleted mice showed a decreased expression of anti-inflammation cytokine and lower-level expression of CTLA-4. In all, our study indicated that Treg cells participated in regulating the 1,3-\u03b2-glucan-induced lung inflammation. Depletion of Treg cells aggravated the 1,3-\u03b2-glucan-induced lung inflammation, regulated the Th1/Th2 balance by enhancing Th1 response. Treg cells exerted their modulation function depending on both direct and indirect mechanism during the 1,3-\u03b2-glucan-induced lung inflammation.",
        "keywords": [
            "1",
            "3-b-glucanregulatory t cellslung inflammationth1/th2"
        ],
        "authors": [
            {
                "name": "Fangwei Liu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 110001 Shenyang, Liaoning, People\u2019s Republic of China"
            },
            {
                "name": "Dong Weng",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 110001 Shenyang, Liaoning, People\u2019s Republic of China"
            },
            {
                "name": "Ying Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 110001 Shenyang, Liaoning, People\u2019s Republic of China"
            },
            {
                "name": "Laiyu Song",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 110001 Shenyang, Liaoning, People\u2019s Republic of China"
            },
            {
                "name": "Cuiying Li",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 110001 Shenyang, Liaoning, People\u2019s Republic of China"
            },
            {
                "name": "Lei Dong",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 110001 Shenyang, Liaoning, People\u2019s Republic of China"
            },
            {
                "name": "Yuan Wang",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 110001 Shenyang, Liaoning, People\u2019s Republic of China"
            },
            {
                "name": "Shasha Tao",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 110001 Shenyang, Liaoning, People\u2019s Republic of China"
            },
            {
                "name": "Jie Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 110001 Shenyang, Liaoning, People\u2019s Republic of China"
            }
        ],
        "venue": "Archives of toxicology",
        "year": 2011
    },
    "wgGtYUhY": {
        "id": "wgGtYUhY",
        "title": "Inhibition of latent transforming growth factor-\u03b21 activation by lentivirus-mediated short hairpin RNA targeting the CD36 gene in NR8383 cells",
        "abstract": "CD36, a cell surface receptor for thrombospondin-1 (TSP-1), is believed to interact with latent transforming growth factor-beta1 (L-TGF-beta1) thereby activating its fibrogenic bioactivity. In this study, a lentiviral vector expressing a short hairpin RNA (shRNA) targeting the rat CD36 gene (Lv-shCD36) is developed and tested. To observe the inhibitory effect of Lv-shCD36 on the activation of L-TGF-beta1, a rat alveolar macrophage cell line (NR8383), infected with either Lv-shCD36 or Lv-shCD36-NC (non-silenced control lentivirus), was treated with 0.1 microg/ml bleomycin, which is known to stimulate alveolar macrophages to release increasing amounts of TGF-beta1. The results show that Lv-shCD36 can suppress expression of CD36 mRNA and protein in bleomycin-treated NR8383 cells. By quantifying active and total TGF-beta1 in the supernatant, it was discovered that the quantity of total TGF-beta1 is not significantly different between the three groups, while the quantity and percent of active TGF-beta1 in the Lv-shCD36 group was significantly lower than in either the bleomycin-treated group or the Lv-shCD36-NC group, respectively (P < 0.05). These results suggest that Lv-shCD36 can inhibit activation of L-TGF-beta1 secreted in bleomycin-treated NR8383 cells by decreasing the expression of CD36 on the cell membrane, thereby reducing binding of CD36 to TSP-1.",
        "keywords": [
            "cd36 \ufffd short hairpin rna \ufffd lentiviral vectorlatent transforming growth factor-b1 \ufffd nr8383 cells",
            "cell line",
            "transforming growth factor"
        ],
        "authors": [
            {
                "name": "Xin Wang",
                "org": "China Medical University Division of Pneumoconiosis, School of Public Health 92 North 2nd 110001 Heping District, Shenyang People\u2019s Republic of China"
            },
            {
                "name": "Ying Chen",
                "org": "China Medical University Division of Pneumoconiosis, School of Public Health 92 North 2nd 110001 Heping District, Shenyang People\u2019s Republic of China"
            },
            {
                "name": "Lina Lv",
                "org": "China Medical University Division of Pneumoconiosis, School of Public Health 92 North 2nd 110001 Heping District, Shenyang People\u2019s Republic of China"
            },
            {
                "name": "Jie Chen",
                "org": "China Medical University Division of Pneumoconiosis, School of Public Health 92 North 2nd 110001 Heping District, Shenyang People\u2019s Republic of China"
            }
        ],
        "venue": "Molecular Biology Reports",
        "year": 2010
    },
    "cQ26uZyX": {
        "id": "cQ26uZyX",
        "title": "Determination of ameliorable health impairment influencing health-related quality of life among patients with silicosis in china: A cross-sectional study",
        "abstract": "The association between health-related quality of life (HRQOL) and ameliorable health impairment was examined in 208 Chinese in-patients with silicosis, in April 2010. Median St George's Respiratory Questionnaire scores for symptom and activity impairment, social support rating scale and geriatric depression scale scores for patients were 57.24, 59.45, 35 and 5, respectively. Median 36-item short-form health survey physical component (PCS) and mental component (MCS) scores were 47.17 and 51.05, respectively. Lower than median PCS scores (< 47) were significantly associated with high levels of symptom and activity impairment. Lower than median MCS scores (< 51) were significantly associated with high levels of depression and activity impairment. Encouraging patients to participate in daily activities may alleviate activity impairment. Reasonable financial compensation may help to maintain and improve social support levels. \u00a9 2011 Field House Publishing LLP.",
        "keywords": [
            "depression",
            "health impairment",
            "quality of life",
            "silicosis",
            "social support"
        ],
        "authors": [
            {
                "name": "Hongbo Liu",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Bo Yan",
                "org": "Shenyang No. 9 Hospital(Shenyang No. 9 Hospital,Shenyang No.9 Hospital),Shenyang,China"
            },
            {
                "name": "Bing Han",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Jinkai Sun",
                "org": "Shenyang No. 9 Hospital(Shenyang No. 9 Hospital,Shenyang No.9 Hospital),Shenyang,China"
            },
            {
                "name": "Yang Yang",
                "org": "Shenyang No. 9 Hospital(Shenyang No. 9 Hospital,Shenyang No.9 Hospital),Shenyang,China"
            },
            {
                "name": "Jie Chen",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            }
        ],
        "venue": "The Journal of international medical research",
        "year": 2011
    },
    "GQccBfx3": {
        "id": "GQccBfx3",
        "title": "Developmental iodine deficiency and hypothyroidism impair spatial memory in adolescent rat hippocampus: involvement of CaMKII, calmodulin and calcineurin.",
        "abstract": "Developmental iodine deficiency (ID) leads to inadequate thyroid hormone that impairs learning and memory with an unclear mechanism. Here, we show that hippocampal calcium/calmodulin-dependent protein kinase II (CaMKII), calmodulin and calcineurin are implicated in the impaired spatial memory in adolescent rats following developmental ID and hypothyroidism. Three developmental rat models were created by administrating dam rats with either iodine-deficient diet or propylthiouracil (PTU, 5 or 15 ppm)-added drinking water from gestational day (GD) 6 till postnatal day (PN) 28. Then, the spatial memory to a water maze test was studied in pups before PN42. After testing periods, the latency to platform and the number of error in iodine-deficient and 15 ppm PTU-treatment groups were significantly higher than those in the controls (P < 0.05). Total and phosphorylated CaMKII, calmodulin, and calcineurin in the hippocampus were detected with both the immunohistochemistry and western blotting. Without going through water maze test, iodine-deficient and 15 ppm PTU-treatment groups showed significantly lower CaMKII and calmodulin and significantly higher calcineurin than the controls in hippocampal CA1 and CA3 regions (P < 0.05). After trials of water maze task, however, CaMKII and calmodulin were up-regulated and calcineurin was down-regulated in control group (P < 0.05), but not in iodine-deficient and 15 ppm PTU-treatment groups. Data indicate that hippocampal CaMKII, calmodulin, and calcineurin are involved in the impaired spatial memory induced by developmental ID and hypothyroidism.",
        "keywords": [
            "Iodine deficiency",
            "Hypothyroidism",
            "Spatial memory",
            "CaMKII",
            "Calmodulin",
            "Calcineurin"
        ],
        "authors": [
            {
                "name": "Jing Dong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001 People\u2019s Republic of China"
            },
            {
                "name": "Wanyang Liu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001 People\u2019s Republic of China"
            },
            {
                "name": "Yi Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001 People\u2019s Republic of China"
            },
            {
                "name": "Yi Hou",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001 People\u2019s Republic of China"
            },
            {
                "name": "Hongde Xu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001 People\u2019s Republic of China"
            },
            {
                "name": "Jian Gong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001 People\u2019s Republic of China"
            },
            {
                "name": "Qi Xi",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001 People\u2019s Republic of China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001 People\u2019s Republic of China"
            }
        ],
        "venue": "Neurotoxicity research",
        "year": 2011
    },
    "YPOywtYd": {
        "id": "YPOywtYd",
        "title": "Congenital iodine deficiency and hypothyroidism impair LTP and decrease C-fos and C-jun expression in rat hippocampus.",
        "abstract": "Iodine is essential for the synthesis of triiodothyronine (T(3)) and thyroxine (T(4)). Iodine deficiency leads to inadequate thyroid hormone. Thyroid hormones deficiency during brain development affects cognitive functions, such as attention, learning, and memory. However, the mechanism underlying these deficits is unclear. To investigate the role of iodine deficiency and hypothyroidism in synaptic plasticity, this study examined the induction of long-term synaptic plasticity (LTP) and expression of immediate early (IEA) gene proteins in rat hippocampus following congenital iodine deficiency or hypothyroidism. Through gestation and lactation, iodine-deficient or hypothyroid dam rats were administered with either iodine-deficient diet or methimazole-added drinking water. Exposure was terminated on postnatal day (PN) 30. In hippocampus of pup rats, the induction of LTP in area CA1 was determined on PN60 and the expression of c-fos and c-jun proteins was examined on PN20, PN30 and PN60. Compared to control pups, both treated groups have shown: (1) significantly lower concentrations of serum FT(3) and FT(4), (2) much smaller population spike (PS) amplitude (p<0.01) and field-excitatory postsynaptic potential (f-EPSP) slope induced by high-frequency stimulation (HFS) (P<0.01), and (3) significantly lower integrated optical density (IOD) total of c-fos and c-jun expression (P<0.05 or P<0.01). In summary, iodine deficiency and hypothyroidism during critical periods of brain development impair LTP induction and decrease the expression of c-fos and c-jun proteins in hippocampus.",
        "keywords": [
            "hypothyroidism",
            "cognitive function",
            "ieg",
            "iodine deficiency",
            "synaptic plasticity",
            "brain development",
            "critical period"
        ],
        "authors": [
            {
                "name": "Jing Dong",
                "org": "School of Public Health, China Medical University, 92 North 2nd Road, Shenyang 110001, PR China"
            },
            {
                "name": "Hongbo Yin",
                "org": "Shenyang Municipal Center for Disease Control and Prevention, Shenyang, PR China"
            },
            {
                "name": "Wanyang Liu",
                "org": "School of Public Health, China Medical University, 92 North 2nd Road, Shenyang 110001, PR China"
            },
            {
                "name": "Ping Wang",
                "org": "Shenyang Municipal Center for Disease Control and Prevention, Shenyang, PR China"
            },
            {
                "name": "Ying Jiang",
                "org": "School of Public Health, China Medical University, 92 North 2nd Road, Shenyang 110001, PR China"
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Neurotoxicology",
        "year": 2005
    },
    "j2ZlLYkX": {
        "id": "j2ZlLYkX",
        "title": "Maternal di-(2-ethylhexyl) phthalate exposure inhibits cerebellar granule precursor cell proliferation via down-regulating the Shh signaling pathway in male offspring.",
        "abstract": "Di-(2-ethylhexyl) phthalate (DEHP) is an endocrine disrupting chemical (EDC) widely used as a plasticizer in many materials. Epidemiological investigations have shown that DEHP exposure during early development is related to cerebellar-related adverse neurodevelopmental outcomes. However, animal studies involving the effect of DEHP exposure on cerebellar development have rarely been reported and the potential mechanisms are unclear. The aim of this study was to investigate the effect of maternal DEHP exposure on the proliferation of cerebellar granule cell precursor cells (GCPs) and the mechanisms involved. Wistar rats were randomly assigned to four exposure groups and given 0, 30, 300, or 750\u202fmg/kg/d DEHP by intragastric administration from gestational day (GD) 0 to postnatal day (PN) 21. Exposure to 300 and 750\u202fmg/kg/d DEHP restrained GCPs proliferation and impaired neurodevelopment for males. Furthermore, exposure to 300 and 750\u202fmg/kg/d DEHP decreased male pups protein expressions and mRNA levels of molecules related to proliferation, including Shh, Gli1, N-Myc, CyclinD1. In addition, the estrogen level and aromatase expression also reduced in male pups after maternal exposure to DEHP. However, effects on females were not obvious. These results suggested that 300 and 750\u202fmg/kg/d DEHP exposure inhibit the proliferation of GCPs in male offspring and ultimately contribute to the impairment of neuromotor development. This, may be caused by the down-regulation of Shh signaling. And the susceptibility of male offspring to DEHP exposure may be attributed to the decreased estrogen level and aromatase expression in male pup's cerebellum.",
        "keywords": [
            "Cerebellum",
            "DEHP",
            "EDCs",
            "Granule cell precursor",
            "Proliferation"
        ],
        "authors": [
            {
                "name": "Yuanyuan Fu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, PR China."
            },
            {
                "name": "Jing Dong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, PR China."
            },
            {
                "name": "Mingdan You",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, PR China."
            },
            {
                "name": "Zhangzhao Cong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, PR China."
            },
            {
                "name": "Lingling Wei",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, PR China."
            },
            {
                "name": "Hui Fu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, PR China."
            },
            {
                "name": "Yi Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, PR China."
            },
            {
                "name": "Yuan Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, PR China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, PR China. Electronic address: jchen@cmu.edu.cn."
            }
        ],
        "venue": "Chemosphere",
        "year": 2018
    },
    "JFACN0Xh": {
        "id": "JFACN0Xh",
        "title": "Assessment of respiration-related quality of life of Chinese patients with silicosis and its influencing factors using the St. George's Respiratory Questionnaire (SGRQ).",
        "abstract": "The aims are to assess respiration-related quality of life using the St. George Respiratory Questionnaire and determine its influencing factors among patients with silicosis in China.The incidence of silicosis had an increasing trend in recent years in developing countries. Although the majority of patients with silicosis are in therapy routinely, the patients' quality of life has been impaired because silicosis cannot be cured. The study on quality of life of patients with silicosis is few, and clinical physicians have difficulty in planning to promote quality of life of patients with silicosis according to the current health situation.A cross-sectional design was used for this study.A survey was performed on patients with silicosis by face-to-face interview in the Shenyang No. 9 Hospital in China. The St. George Respiratory Questionnaire was used to assess respiration-related quality of life.In all 208 enrolled patients with silicosis, symptoms, activity and impacts scores were 56\u00b702, 56\u00b746 and 52\u00b733, respectively. Lower impacts scores were found comparing with symptoms and activity ones. Patient age was associated with an expected decrease in respiration-related quality of life. Patients with longer duration of exposure had higher total scores of the St. George Respiratory Questionnaire, indicating worse quality of life. Patients with more co-morbidities reported worse quality of life.Patients with silicosis were found relatively moderate respiration-related quality of life. Shortening dust exposure, decreasing the number of co-morbidity and controlling the occurrence of pulmonary tuberculosis could improve respiration-related quality of life.As indicated by the results of this study, the number of co-morbidity negatively impact the quality of life of patients with silicosis. Clinical physicians and nurses should pay close attention to the co-morbidity to promote quality of life of patients with silicosis according to the current health situation.",
        "keywords": [
            "clinical characteristics",
            "dust exposure",
            "silicosis",
            "physicians",
            "st. george respiratory questionnaire",
            "respiration-related quality of life"
        ],
        "authors": [
            {
                "name": "Hongbo Liu",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Bo Yan",
                "org": "Shenyang No. 9 Hospital(Shenyang No. 9 Hospital,Shenyang No.9 Hospital),Shenyang,China"
            },
            {
                "name": "Bing Han",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Jinkai Sun",
                "org": "Shenyang No. 9 Hospital(Shenyang No. 9 Hospital,Shenyang No.9 Hospital),Shenyang,China"
            },
            {
                "name": "Yang Yang",
                "org": "Shenyang No. 9 Hospital(Shenyang No. 9 Hospital,Shenyang No.9 Hospital),Shenyang,China"
            },
            {
                "name": "Jie Chen",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            }
        ],
        "venue": "Journal of clinical nursing",
        "year": 2012
    },
    "qzpmI3e9": {
        "id": "qzpmI3e9",
        "title": "Estimates and Predictions of Coal Workers\u2019 Pneumoconiosis Cases among Redeployed Coal Workers of the Fuxin Mining Industry Group in China: A Historical Cohort Study",
        "abstract": "This research was aimed at estimating possible Coal workers\u2019 pneumoconiosis (CWP) cases as of 2012, and predicting future CWP cases among redeployed coal workers from the Fuxin Mining Industry Group. This study provided the scientific basis for regulations on CWP screening and diagnosis and labor insurance policies for redeployed coal workers of resource-exhausted mines. The study cohort included 19,116 coal workers. The cumulative incidence of CWP was calculated by the life-table method. Possible CWP cases by occupational category were estimated through the average annual incidence rate of CWP and males\u2019 life expectancy. It was estimated that 141 redeployed coal workers might have suffered from CWP as of 2012, and 221 redeployed coal workers could suffer from CWP in the future. It is crucial to establish a set of feasible and affordable regulations on CWP screening and diagnosis as well as labor insurance policies for redeployed coal workers of resource-exhausted coal mines in China.",
        "keywords": "",
        "authors": [
            {
                "name": "Bing Han",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning, 110122, China"
            },
            {
                "name": "Hongbo Liu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning, 110122, China"
            },
            {
                "name": "Guojiang Zhai",
                "org": "Fuxin Mining Area Social Security Administration Center, Fuxin, Liaoning, 123000, China"
            },
            {
                "name": "Qun Wang",
                "org": "Fuxin Mining Area Social Security Administration Center, Fuxin, Liaoning, 123000, China"
            },
            {
                "name": "Jie Liang",
                "org": "Institute for Occupational Disease Prevention and Treatment of the Fuxin Mining Industry Group, Fuxin, Liaoning, 123000, China"
            },
            {
                "name": "Mengcang Zhang",
                "org": "Institute for Occupational Disease Prevention and Treatment of the Fuxin Mining Industry Group, Fuxin, Liaoning, 123000, China"
            },
            {
                "name": "Kai Cui",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning, 110122, China"
            },
            {
                "name": "Fuhai Shen",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning, 110122, China"
            },
            {
                "name": "Hongbo Yi",
                "org": "Fuxin Mining Area Social Security Administration Center, Fuxin, Liaoning, 123000, China"
            },
            {
                "name": "Yuting Li",
                "org": "Department of Health Statistics, School of Public Health, China Medical University, Shenyang, Liaoning, 110122, China"
            },
            {
                "name": "Yuhan Zhai",
                "org": "Department of Health Statistics, School of Public Health, China Medical University, Shenyang, Liaoning, 110122, China"
            },
            {
                "name": "Yang Sheng",
                "org": "Department of Health Statistics, School of Public Health, China Medical University, Shenyang, Liaoning, 110122, China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning, 110122, China"
            }
        ],
        "venue": "PLOS ONE",
        "year": 2016
    },
    "sNcAcjLq": {
        "id": "sNcAcjLq",
        "title": "Neutralization of interleukin-17A delays progression of silica-induced lung inflammation and fibrosis in C57BL/6 mice.",
        "abstract": "Silica exposure can cause lung inflammation and fibrosis, known as silicosis. Interleukin-17A (IL-17A) and Th17 cells play a pivotal role in controlling inflammatory diseases. However, the roles of IL-17A and Th17 cells in the progress of silica-induced inflammation and fibrosis are poorly understood. This study explored the effects of IL-17A on silica-induced inflammation and fibrosis. We used an anti-mouse IL-17A antibody to establish an IL-17A-neutralized mice model, and mice were exposed to silica to establish an experimental silicosis model. We showed that IL-17A neutralization delayed neutrophil accumulation and progression of silica-induced lung inflammation and fibrosis. IL-17A neutralization reduced the percentage of Th17 in CD4+ T cells, decreased IL-6 and IL-1\u03b2 expression, and increased Tregs at an early phase of silica-induced inflammation. Neutralization of IL-17A delayed silica-induced Th1/Th2 immune and autoimmune responses. These results suggest that IL-17A neutralization alleviates early stage silica-induced lung inflammation and delays progression of silica-induced lung inflammation and fibrosis. Neutralization of IL-17A suppressed Th17 cell development by decreasing IL-6 and/or IL-1\u03b2 and increased Tregs at an early phase of silica-induced inflammation. Neutralization of IL-17A also delayed the Th1/Th2 immune response during silica-induced lung inflammation and fibrosis. IL-17A may play a pivotal role in the early phase of silica-induced inflammation and may mediate the Th immune response to influence silica-induced lung inflammation and fibrosis in mice.",
        "keywords": [
            "interleukin-17a",
            "lung fibrosis",
            "ana",
            "th17",
            "il-17a",
            "silica",
            "tregs",
            "lung inflammation",
            "hln",
            "balf"
        ],
        "authors": [
            {
                "name": "Ying Chen",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Cuiying Li",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Dong Weng",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Laiyu Song",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Wen Tang",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Wujing Dai",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Ye Yu",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Fangwei Liu",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Ming Zhao",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Chunwei Lu",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Jie Chen",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            }
        ],
        "venue": "Toxicology and applied pharmacology",
        "year": 2014
    },
    "jqZT2mFw": {
        "id": "jqZT2mFw",
        "title": "Estimated economic costs of coal workers' pneumoconiosis among coal workers redeployed from the Fuxin mining group in China.",
        "abstract": "Our research estimated the economic costs of possible cases of coal workers' pneumoconiosis (CWP) among redeployed coal workers from the Fuxin Mining Industry Group. The study cohort included 19,116 coal workers between 1965 and 2012. We estimated direct and indirect economic costs due to possible current and future CWP cases among redeployed coal workers. We found as of 2012 that 141 possible CWP cases might have resulted in economic costs of $37.52 million ($33.84 million were direct and $3.68 million indirect). Moreover, 221 possible future CWP cases would result in economic costs of $63.89 million ($57.20 million direct and $6.69 million indirect). Neither the Fuxin Mining Industry Group nor Fuxin could cover the costs of CWP screening and diagnosis, or social security payments for redeployed coal workers. We suggest that China's national government help Liaoning Province and Fuxin focus on health care and social security.",
        "keywords": [
            "Coal workers\u2019 pneumoconiosis",
            "Economic costs",
            "Public health",
            "Redeployed coal workers",
            "Resource-exhausted mines"
        ],
        "authors": [
            {
                "name": "Bing Han",
                "org": "Department of Health Statistics, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Hongbo Liu",
                "org": "Department of Health Statistics, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Guojiang Zhai",
                "org": "Fuxin Mining Area Social Security Administration Center, Fuxin, China."
            },
            {
                "name": "Qun Wang",
                "org": "Fuxin Mining Area Social Security Administration Center, Fuxin, China."
            },
            {
                "name": "Jie Liang",
                "org": "Institute for Occupational Disease Prevention and Treatment of Fuxin Mining Industry Group, Fuxin, China."
            },
            {
                "name": "Mengcang Zhang",
                "org": "Institute for Occupational Disease Prevention and Treatment of Fuxin Mining Industry Group, Fuxin, China."
            },
            {
                "name": "Kai Cui",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 77 Puhe Road, Shenyang, Liaoning, 110122, China."
            },
            {
                "name": "Fuhai Shen",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 77 Puhe Road, Shenyang, Liaoning, 110122, China."
            },
            {
                "name": "Hongbo Yi",
                "org": "Fuxin Mining Area Social Security Administration Center, Fuxin, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 77 Puhe Road, Shenyang, Liaoning, 110122, China. jchen@cmu.edu.cn."
            }
        ],
        "venue": "Journal of public health policy",
        "year": 2018
    },
    "ck6T7PsT": {
        "id": "ck6T7PsT",
        "title": "Cloning of mouse TSR2-3/TSP-1 gene segments and expression and purification of their coding protein fused with GST",
        "abstract": "Objective: To obtain mouse TSR2-3/TSP-1 segments,and to express the target protein efficiently in Escherichia coli(E.coli) BL21 and purify it.Methods: TSR2-3/TSP-1 gene segments were amplified by reverse transcriptase polymerase chain reaction(RT-PCR) from mouse lung total RNA.After sequenced,the reconstructed expression vectors were constructed by enzyme digestion and cloned into expression vector pGEX-5X-2.Then the reconstructed vectors were transformed into E.coli BL21.Recombinant GST fusion proteins were expressed by the induction of IPTG and purified through GST-affinity column.Results: The sequences of cloned mouse TSR2-3 gene segments were identical with those reported in GenBank.A protein band of 39 kDa appeared on SDS-PAGE gel after the expressed GST fusion protein was separated by SDS-PAGE.Then the high purity fusion protein was obtained.Conclusion: The mouse TSR2-3 gene segments could be successfully cloned and efficiently expressed in E.coli BL21,and the GST-fused target proteins with high purity could be obtained.",
        "keywords": [
            "expression",
            "TSR2-3 gene",
            "cloning",
            "purification"
        ],
        "authors": [
            {
                "name": "WANG Xin",
                "org": "Laboratory of Pneumoconiosis,College of Public Health,China Medical University,Shenyang ,China"
            },
            {
                "name": "LIU Tong",
                "org": "Department of Cell Biology,College of Basic Medical Sciences"
            },
            {
                "name": "CHEN Ying",
                "org": "Laboratory of Pneumoconiosis,College of Public Health,China Medical University,Shenyang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Laboratory of Pneumoconiosis,College of Public Health,China Medical University,Shenyang ,China"
            }
        ],
        "venue": "Journal of China Medical University",
        "year": 2006
    },
    "vy63gN78": {
        "id": "vy63gN78",
        "title": "Mitogen-activated protein kinase signaling is involved in nonylphenol-induced proinflammatory cytokines secretion by BV2 microglia.",
        "abstract": "Microglia (MG) are the key cells involved in the innate immune response in the central nervous system, and their activation has been linked to inflammation and neurotoxicity by the production of proinflammatory cytokines. Recently, researchers have found that nonylphenol (NP), a ubiquitous endocrine disrupting chemical, could impair neurodevelopment and cognitive memory performance. However, whether NP affects the inflammatory responses of MG remains to be elucidated. The aim of this study was to explore the effects of NP on the inflammatory responses of BV2 MG and the underlying mechanisms. Our results showed that NP increased the secretion of interleukin (IL)-6 and IL-1\u03b2 in BV2 MG. Increased phosphorylation of Akt, JNK and p38 mitogen-activated protein kinase and decreased phosphorylation of ERK were observed in NP-treated MG. The inflammatory transcription factor activator protein 1 was also activated in NP-treated BV2 MG. These results suggest that NP may activate Akt/mitogen-activated protein kinase/activator protein 1 signaling in MG and subsequently increase IL-6 and IL-1\u03b2 secretion.",
        "keywords": [
            "BV2 microglia",
            "MAP kinase signaling",
            "nonylphenol",
            "proinflammatory cytokines"
        ],
        "authors": [
            {
                "name": "Weijia Gu",
                "org": "Department of Occupational and Environmental Health, School of Public Heath, China Medical University, Shenyang, People's Republic of China."
            },
            {
                "name": "Yi Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Heath, China Medical University, Shenyang, People's Republic of China."
            },
            {
                "name": "Zhenmin Qiu",
                "org": "Department of Occupational and Environmental Health, School of Public Heath, China Medical University, Shenyang, People's Republic of China."
            },
            {
                "name": "Jing Dong",
                "org": "Department of Occupational and Environmental Health, School of Public Heath, China Medical University, Shenyang, People's Republic of China."
            },
            {
                "name": "Yuan Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Heath, China Medical University, Shenyang, People's Republic of China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Heath, China Medical University, Shenyang, People's Republic of China."
            }
        ],
        "venue": "Journal of applied toxicology : JAT",
        "year": 2018
    },
    "ZHgYBZlt": {
        "id": "ZHgYBZlt",
        "title": "IL-10-Producing B Cells Suppress Effector T Cells Activation and Promote Regulatory T Cells in Crystalline Silica-Induced Inflammatory Response In Vitro.",
        "abstract": "Long-term exposure to crystalline silica leads to silicosis, which is characterized by persistent lung inflammation and lung fibrosis. Multiple immune cells have been demonstrated to participate in crystalline silica-induced immune responses. Our previous study indicated that B10 could control lung inflammation through modulating the Th balance in experimental silicosis in mice. However, the regulatory mechanism of B10 on CD4 T cells is still unclear. MACS-sorted CD19 B cells from the three different groups were cultured with CD4 T cells either with or without transwell insert plates to evaluate the effects of B10 on CD4 T cells, including Teff and Treg. B10 was eliminated by anti-CD22 application in vivo. Flow cytometry was used to test the frequencies of CD4 T cells, and the expressions of the related cytokines were detected by real-time PCR and CBA. Insufficient B10 elevated the levels of proinflammatory cytokines and promoted Th responses in a way independent upon cell-cell contact in the Teff and B cell coculture system. B10 could both increase Treg activity and enhance conversion of Teff into Treg. Our findings demonstrated that B10 could affect Th responses by the release of IL-10, enhancing Treg functions and converting Teff into Treg.",
        "keywords": "",
        "authors": [
            {
                "name": "Yiping Lu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Fangwei Liu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Chao Li",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Ying Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Dong Weng",
                "org": "Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China."
            },
            {
                "name": "Jie Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            }
        ],
        "venue": "Mediators of inflammation",
        "year": 2017
    },
    "UDoXXTbm": {
        "id": "UDoXXTbm",
        "title": "The influence of the functional capacity on subjective well-being and quality of life of patients with silicosis.",
        "abstract": "Silicosis is a fibrosing and irreversible lung disease. In China, 9870 new silicosis cases were reported in 2010. The physical and mental status of patients with silicosis should be paid attention to. The aims of this study were to evaluate the influence of the patients' functional capacity on subjective well-being (SWB) and quality of life (QOL), provide the scientific basis for further intervention measures, and improve their health status.We investigated 324 inpatients with silicosis during April 2011 to September 2011. The 6-minute walk test (6MWT) was the major methodology used to evaluate the functional capacity, the SF-12 (Short Form-12) to evaluate the QOL, and the MUNSH (Memorial University of Newfoundland Scale of Happiness) scale to evaluate the SWB.The distance of 6MWT suggested a significant and positive correlation with SWB and QOL of patients with silicosis (P < 0.01). In China, patients with silicosis had low SWB and QOL.The SWB and QOL of patients with silicosis are still relatively low and their health status needs improvement. At the same time, longer distances walked by patients suggest more positive influences on their SWB and QOL. It indicates that when the 6MWT cooperates with SWB and QOL, it may be able to get more accurate evaluation results of patients' survival status.",
        "keywords": [
            "quality of life",
            "silicosis",
            "6-minute walk test",
            "functional capacity",
            "subjective well-being",
            "subjective well being"
        ],
        "authors": [
            {
                "name": "Bing Han",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Bo Yan",
                "org": "Shenyang No. 9 Hospital(Shenyang No. 9 Hospital,Shenyang No.9 Hospital),Shenyang,China"
            },
            {
                "name": "Na Zhao",
                "org": "Shenyang No. 9 Hospital(Shenyang No. 9 Hospital,Shenyang No.9 Hospital),Shenyang,China"
            },
            {
                "name": "Jian Zhang",
                "org": "Shenyang No. 9 Hospital(Shenyang No. 9 Hospital,Shenyang No.9 Hospital),Shenyang,China"
            },
            {
                "name": "Jinkai Sun",
                "org": "Shenyang No. 9 Hospital(Shenyang No. 9 Hospital,Shenyang No.9 Hospital),Shenyang,China"
            },
            {
                "name": "Xibing Lei",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Chao Li",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Hongbo Liu",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Jie Chen",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            }
        ],
        "venue": "Aging & mental health",
        "year": 2013
    },
    "avGLrVNh": {
        "id": "avGLrVNh",
        "title": "The effect of CD36 synthetic peptide on expression of collagen \u2160 and \u2162 of lung tissues in the experimental silica dust exposed mice",
        "abstract": "Objective To explore whether CD36 synthetic peptide(93-110)had the inhibitory effect on experimental silicosis in mice or not.Methods Mice were divided randomly into four experimental groups:saline control,SiO2 exposed group,CD36(93-110)functional peptide treated group and CD36(208-225)control peptide treated group.Mice were killed at 7,14 and 21days after instillation,respectively,determinate the lung coefficient,meanwhile,the expressions of collagen \u2160 and \u2162 in lung tissues were measured by immunohistochemical technique.Results The results showed that there was obvious reduce of lung coefficient and collagen \u2160 and \u2162 expression could be seen in mice of CD36 synthetic peptide group(P<0.05)at 14 and 21days after instillation.Quantitative image analysis showed that average of integrated optical density(OD)of collagen \u2160 and \u2162 in CD36 synthetic peptide group was lower significantly than SiO2 group and CD36 control peptide group at 14 and 21 days after instillation(P<0.05).Conclusions The results suggest that CD36 functional peptide(93-110)has good inhibiting effect on pulmonary fibrosis in experimental silicosis mice.",
        "keywords": [
            "Functional peptide",
            "CD36",
            "Silicosis",
            "Collagen \u2160 and \u2162",
            "SiO2"
        ],
        "authors": [
            {
                "name": "LV Li-na",
                "org": "School of Public Health,China Medical University,Shenyang ,China"
            },
            {
                "name": "WANG Xin",
                "org": "School of Public Health,China Medical University,Shenyang ,China"
            },
            {
                "name": "CHEN Ying",
                "org": "School of Public Health,China Medical University,Shenyang ,China"
            },
            {
                "name": "LIU Fang-wei",
                "org": "School of Public Health,China Medical University,Shenyang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Public Health,China Medical University,Shenyang ,China"
            }
        ],
        "venue": "Chinese Journal of Industrial Medicine",
        "year": 2009
    },
    "XSOEOyDZ": {
        "id": "XSOEOyDZ",
        "title": "Effect of iodine deficiency and hypothyroidism on the protein expressions of CaMK\u2161in the hippocampus of pups",
        "abstract": "Objective To observe the effect of iodine deficiency and hypothyroidism on the protein expressions of CaMK\u2161 in the hippocampus of pups. Methods Female Wistar rats ( n = 28) after pregnancy were randomly divided into control group,hypothyroid group and iodine deficient group. According to the dose of PTU in fed water, hypothyroid group was divided into 5 mg /L group and 15 mg /L group ( 7 in each ). 5 pups from each group were sacrificed and perfused intracardially in PN7,PN14 and PN21. Brains were removed,fixed and sectioned coronally. All sections were observed and analyzed the protein exression of CaMK \u2161 by immunohistochemistry in the hippocampus CA1,CA3 and DG regions. Results Control group in CA1,CA3 and DG regions of the hippocampus had strong positive staining and the cytoplasm of neurons were filled with CaMK\u2161. The distribution of the immune reaction product in hippocampus of 5mg / L,15mg / L and iodine groups were in line with the control group,but the staining intensity as compared with the control group gradually decreased. In PN21 and PN14,integrated optical density average of CaMK\u2161 in CA1,CA3 and DG regions of the hippocampus in iodine deficient group [PN21: (26. 05 \u00b1 4. 98)\u3001(30. 79 \u00b1 3. 22)\u3001(26. 40 \u00b1 2. 63); PN14:(25. 48 \u00b1 4. 87)\u3001(44. 17 \u00b1 5. 91)\u3001(26. 41 \u00b1 3. 01)] and 15 mg /L groups [PN21: (17. 02 \u00b1 2. 68)\u3001(24. 57 \u00b1 6. 62)\u3001(20. 18 \u00b1 4. 05); PN14:(20. 66 \u00b1 3. 51)\u3001(34. 94 \u00b1 5. 09)\u3001(27. 32 \u00b1 4. 97)]were significantly lower than those of controls [PN21: (57. 75 \u00b1 13. 22)\u3001(65. 03 \u00b1 6. 20)\u3001(49. 39 \u00b1 8. 41),P < 0. 05; PN14: (54. 08 \u00b1 12. 00)\u3001(71. 04 \u00b1 5. 07)\u3001(78. 52 \u00b1 12. 42),P < 0. 05]. InPN7,integrated optical density average of CaMK \u2161 in CA1 region of the hippocampus in iodine deficient group (25. 74 \u00b1 3. 33) and 15 mg/L groups (26. 89 \u00b1 5. 25) were significantly lower than those of controls(40. 53 \u00b1 3. 65),P < 0. 05. Conclusion Iodine deficiency and hypothyroidism may decrease the protein expression of CaMK \u2161.",
        "keywords": [
            "CaMK\u2161",
            "hypothyroidism",
            "hippocampus",
            "iodine deficiency"
        ],
        "authors": [
            {
                "name": "WEI Wei",
                "org": " Department of Occupational and Environmental Health,School of Public Health, China Medical University,Shenyang ,China"
            },
            {
                "name": "DONG Jing",
                "org": " Department of Occupational and Environmental Health,School of Public Health, China Medical University,Shenyang ,China"
            },
            {
                "name": "LIU Wanyang",
                "org": " Department of Occupational and Environmental Health,School of Public Health, China Medical University,Shenyang ,China"
            },
            {
                "name": "WANG Yi",
                "org": " Department of Occupational and Environmental Health,School of Public Health, China Medical University,Shenyang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": " Department of Occupational and Environmental Health,School of Public Health, China Medical University,Shenyang ,China"
            }
        ],
        "venue": "Journal of Hygiene Research",
        "year": 2010
    },
    "VFqhPg1A": {
        "id": "VFqhPg1A",
        "title": "Perinatal iodine deficiency and hypothyroidism increase cell apoptosis and alter doublecortin and reelin protein expressions in rat cerebellum.",
        "abstract": "Adequate thyroid hormone is critical for cerebellar development. Developmental hypothyroidism induced by iodine deficiency during the perinatal period results in permanent impairments of cerebellar development with an unclear mechanism. In the present study we investigated effects of perinatal iodine deficiency and hypothyroidism on cerebellar cell apoptosis, doublecortin (Dcx) and reelin. Apoptosis is an essential part of neural development. Dcx and reelin are two important molecules involved in neuronal migration, structure, and development in cerebellum.Two developmental rat models were created by administering dam rats with either iodine-deficient diet or propylthiouracil (PTU, 5 ppm or 15 ppm)-added drinking water from gestational day (GD) 6 until postnatal day (PND) 28. TUNEL assay and protein levels of Dcx and reelin in cerebella were assessed on PND14, 21 and 28.Apoptotic cells were increased in the iodine-deficient and PTU-treated rats. Dcx protein levels in the cerebella of iodine-deficient and PTU-treated rats were significantly downregulated on PND14. Interestingly, iodine deficiency and PTU treatment upregulated the levels of Dcx protein on PND21 and 28. Reelin expressions in iodine-deficient and PTU-treated rats were significantly decreased on PND14 and 21. On PND28, reelin expressions of three treated groups were still lower than control group, although without significant difference.These findings may implicate alterations in cell apoptosis and levels of Dcx and reelin in the impairments of cerebellar development induced by developmental iodine deficiency and hypothyroidism.",
        "keywords": [
            "hypothyroidism",
            "apoptosis",
            "reelin",
            "doublecortin",
            "iodine deficiency",
            "cerebellum"
        ],
        "authors": [
            {
                "name": "Yi Wang",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Jiapeng Zhong",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Hongde Xu",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Wei Wei",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Jing Dong",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Fei Yu",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Yuan Wang",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Jian Gong",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Zhongyan Shan",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Weiping Teng",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Jie Chen",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            }
        ],
        "venue": "Archives of medical research",
        "year": 2012
    },
    "ofLypd3S": {
        "id": "ofLypd3S",
        "title": "Developmental iodine deficiency and hypothyroidism impaired in vivo synaptic plasticity and altered PKC activity and GAP-43 expression in rat hippocampus",
        "abstract": "To investigate the mechanism by which developmental iodine deficiency and hypothyroidism affect long-term synaptic plasticity, we chose to study the activity of protein kinase C (PKC) and the expression of growth-associated protein-43 (GAP-43) in pup hippocampus following developmental hypothyroidism. Two developmental hypothyroid rat models were created with iodine-deficient diet (IDD) and water containing methimazole. Compared to the control group, in developmental hypothyroid rats: (i) HFS induced less in vivo LTP and more long-term depression (LTD) in area CA1 on postnatal day (PN) 60 (P < 0.0 5); (ii) in IDD pups, HFS-induced LTP showed much smaller population spike amplitude (P < 0.01) and slope of field-excitatory postsynaptic potential (P < 0.01); (iii) PKC activity, on PN30, was much higher on cell membrane and lower in cytosol (P < 0.05) without change of total PKC level (P > 0.05); and (iv) GAP-43 expression was significantly lower (P < 0.01) on both PN30 and PN60. Developmental iodine deficiency and hypothyroidism affect PKC translocation, decrease GAP-43 expression, and impair long-term synaptic plasticity in the rat hippocampus. \u00a9 2010 Maney Publishing.",
        "keywords": [
            "developmental iodine deficiency",
            "gap-43",
            "hypothyroidism",
            "long-term synaptic plasticity",
            "pkc",
            "gap 43"
        ],
        "authors": [
            {
                "name": "Wanyang Liu",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Jing Dong",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Y\u00ec W\u00e1ng",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Qi Xi",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Jie Chen",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            }
        ],
        "venue": "Nutritional Neuroscience",
        "year": 2010
    },
    "OfR9K7OQ": {
        "id": "OfR9K7OQ",
        "title": "Effects of iodine deficient and hypothyroid on protein expression of extracellular signal-regulate kinase (ERK1/2) in the cerebellum of rats",
        "abstract": "Objective: To study the effects of iodine deficiency and hypothyroidism on protein expression of extracellular signal-regulate kinase (ERK1/2) in the cerebellum of rats. Methods: Twenty-eight healthy Wistar rats, female, 60 days old, were randomly divided according to their body weight into control group, iodine deficient group and hypothyroidism groups. Hypothyroidism groups in accordance with drinking water containing propylthiouracil (PTU) were divided into doses of 5 mg/L and 15 mg/L groups, 7 rats in each group. Rats after pregnancy, iodine deficient rats were administered with iodine-deficient diet and hypothyroid rats were administered with PTU in drinking water. Pup's cerebellum in each group were weighed on day 14, 21, 28 and 42. Cerebellum tissue was observed for cerebellar morphology using silver staining and detected for ERK1/2 protein using immunohistochemistry on day 7, 14, 21, 28 and 42. Results: On day 14, 21, 28 and 42, cerebellum weight of pups from iodine-deficient [(0.0945 \u00b1 0.0233), (0.1347 \u00b1 0.0046), (0.1542 \u00b1 0.0094), (0.1949 \u00b1 0.0048)g] were significantly lighter than control [(0.1856 \u00b1 0.0123), (0.2049 \u00b1 0.0098), (0.2268 \u00b1 0.0065), (0.2606 \u00b1 0.0086)g, all P < 0.05] and hypothyroidism groups [for 5 mg/L group: (0.1741 \u00b1 0.0172), (0.1927 \u00b1 0.0103), (0.2181 \u00b1 0.0064), (0.2583 \u00b1 0.0054)g, all P < 0.05; for 15 mg/L group: (0.1604 \u00b1 0.0083), (0.1682 \u00b1 0.0103), (0.1996 \u00b1 0.0073) and (0.2579 \u00b1 0.0067)g, all P < 0.05] the difference had statistical significance (F = 6.325, 8.870, 16.191 and 21.574, all P < 0.05). Compared to the controls on day 7, iodine-deficient group didn't have clear layers; on day 21, disappearance of external granule cells from iodine-deficient and 15 mg/L groups was delayed, still two or three layer external granule cells remained; on day 28 and 42, molecular layer from 5, 15 mg/L and iodine-deficient groups and became thinner. Immunohistochemistry showed that on day 7, there was no statistical difference of integrated optical density average of ERK1/2, in all the groups (F = 1.102, P > 0.05); on day 14, 21, 28 and 42, integrated optical density average of ERK1/2 in iodine-deficient group [(7.3245 \u00b1 0.5070), (8.3606 \u00b1 1.0683), (9.1217 \u00b1 1.0402), (12.1587 \u00b1 0.7581), all P < 0.01] and hypothyroidism groups [for 5 mg/L group: (11.4307 \u00b1 1.5200), (14.919 \u00b1 0.8497), (16.0082 \u00b1 1.1130), (15.7721 \u00b1 0.8293), all P < 0.01; for 15 mg/L group: (7.8538 \u00b1 0.9775), (11.2461 \u00b1 0.8138), (12.78 \u00b1 1.3783), (13.0871 \u00b1 1.1450), all P < 0.01] was significantly lower than those of controls [(16.2831 \u00b1 0.5143), (20.2653 \u00b1 0.9551), (22.7485 \u00b1 1.0267), (22.1725 \u00b1 0.9939), all P < 0.01], the difference having a statistical significance (F = 16.131, 13.543, 26.953, 41.583, all P < 0.01). Conclusions: Iodine deficiency and hypothyroidism during critical periods of brain development may change cerebellar morphology and down regulate the protein expression of ERK1/2, which may result in damage of cerebellum development.",
        "keywords": [
            "Cerebellum",
            "Deficiency diseases",
            "Extracellular signal-regulate kinase (ERK1/2)",
            "Hypothyroidism",
            "Iodine",
            "Rats"
        ],
        "authors": [
            {
                "name": "JinYan Li",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Jing Dong",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Y\u00ec W\u00e1ng",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Jian Gong",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Liang Shan",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "MingQi Gao",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Jie Chen",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            }
        ],
        "venue": "Chinese Journal of Endemiology",
        "year": 2009
    },
    "kUPeRYgQ": {
        "id": "kUPeRYgQ",
        "title": "IL-10-Producing B Cells Regulate T Helper Cell Immune Responses during 1,3-\u03b2-Glucan-Induced Lung Inflammation.",
        "abstract": "With the rapid development of industry and farm, fungi contamination widely exists in occupational environment. Inhalation of fungi-contaminated organic dust results in hypersensitivity pneumonitis. 1,3-\u03b2-Glucan is a major cell wall component of fungus and is considered as a biomarker of fungi exposure. Current studies showed that 1,3-\u03b2-glucan exposure induced lung inflammation, which involved uncontrolled T helper (Th) cell immune responses, such as Th1, Th2, Th17, and regulatory T cell (Treg). A recently identified IL-10-producing B cells (B10) was reported in regulating immune homeostasis. However, its regulatory role in hypersensitivity pneumonitis is still subject to debate. In our study, we comprehensively investigated the role of B10 and the relationship between B10 and Treg in 1,3-\u03b2-glucan-induced lung inflammation. Mice with insufficient B10 exhibited more inflammatory cells accumulation and severer pathological inflammatory changes. Insufficient B10 led to increasing Th1, Th2, and Th17 responses and restricted Treg function. Depletion of Treg before the onset of inflammation could suppress B10. Whereas, Treg depletion only at the late stage of inflammation failed to affect B10. Our study demonstrated that insufficient B10 aggravated the lung inflammation mediated by dynamic shifts in Th immune responses after 1,3-\u03b2-glucan exposure. The regulatory function of B10 on Th immune responses might be associated with Treg and IL-10. Treg could only interact with B10 at an early stage.",
        "keywords": [
            "1",
            "3-\u03b2-glucan",
            "T helper immune responses",
            "lung inflammation",
            "occupational disease",
            "regulatory B cells"
        ],
        "authors": [
            {
                "name": "Fangwei Liu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Xiaowei Lu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Wujing Dai",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Yiping Lu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Chao Li",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Sitong Du",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Ying Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Dong Weng",
                "org": "Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China."
            },
            {
                "name": "Jie Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            }
        ],
        "venue": "Frontiers in immunology",
        "year": 2017
    },
    "Pycivp9l": {
        "id": "Pycivp9l",
        "title": "JPARSS: A Java Parallel Network Package for Grid Computing",
        "abstract": "The emergence of high speed wide area networks makes grid computing a reality. However grid applications that need reliable data transfer still have difculties to achieve optimal TCP performance due to network tuning of TCP window size to improve bandwidth and to reduce la- tency on a high speed wide area network. This paper presents a Java package called JPARSS (Java Parallel Se- cure Stream (Socket)) that divides data into partitions that are sent over several parallel Java streams simultaneously and allows Java or Web applications to achieve optimal TCP performance in a grid environment without the ne- cessity of tuning TCP window size. This package enables single sign-on, certicate delegation and secure or plain- text data transfer using several security components based on X.509 certicate and SSL. Several experiments will be presented to show that using Java parallel streams is more effective than tuning TCP window size. In addition a simple architecture using Web services to facilitate peer to peer and third party le transfer will be presented.",
        "keywords": [
            "grid computing",
            "web service",
            "data transfer"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Walt Akers",
                "org": ""
            },
            {
                "name": "Ying Chen",
                "org": ""
            },
            {
                "name": "William A. Watson III",
                "org": ""
            }
        ],
        "venue": "JCIS",
        "year": 2002
    },
    "QDJty4Sv": {
        "id": "QDJty4Sv",
        "title": "Targeting Mechanics-Induced Fibroblast Activation through CD44-RhoA-YAP Pathway Ameliorates Crystalline Silica-Induced Silicosis.",
        "abstract": "Silicosis is pneumoconiosis of the lung, usually resulting from prolonged exposure to crystalline silica (CS). The hallmark of silicosis is excessive extracellular matrix (ECM) deposition produced by activated fibroblasts. Recent work demonstrated that excessive ECM-forming mechanical cues play an essential role in promoting fibroblast activation and perpetuating fibrotic pathologies. However, the detailed molecular mechanism still needs to be uncovered. : NIH-3T3 fibroblasts were cultured on either 1 kappa (soft) or 60 kappa (stiff) gel-coated coverslips. A series of knockdown and reverse experiments  were performed to establish the signaling for mechanics-induced fibroblast activation. An experimental model of silicosis was established by one-time intratracheal instillation of CS suspension. The cluster of differentiation 44 (CD44) antibody (IM7), dihydrotanshinone I (DHI) and verteporfin (VP) were used to explore the effect of CD44-RhoA-YAP signaling blockade on mechanics-induced fibroblast activation and CS-induced pulmonary fibrosis. : Matrix stiffness could induce nuclear translocation of the Yes-associated protein (YAP) through CD44 in fibroblasts. This effect required RhoA activity and F-actin cytoskeleton polymerization but was independent of Hippo pathway kinases, Mst 1 and Lats 1, forming CD44-RhoA-YAP signaling pathway. Pharmacological upstream blocking by CD44 antibody or downstream blockade of YAP by DHI or VP could attenuate fibroblast migration, invasion, proliferation, and collagen deposition. Furthermore, CD44-RhoA-YAP signaling blockade could alleviate CS-induced fibrosis and improve pulmonary function . : CD44-RhoA-YAP signaling mediates mechanics-induced fibroblast activation. Targeting this pathway could ameliorate crystalline silica-induced silicosis and provide a potential therapeutic strategy to mitigate fibrosis.",
        "keywords": [
            "Yes-associated protein",
            "fibroblast activation",
            "mechanics",
            "silicosis therapy"
        ],
        "authors": [
            {
                "name": "Siyi Li",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Chao Li",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Yiting Zhang",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Xiu He",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Xi Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Xinning Zeng",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Fangwei Liu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Ying Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Jie Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            }
        ],
        "venue": "Theranostics",
        "year": 2019
    },
    "IMBbDJCL": {
        "id": "IMBbDJCL",
        "title": "Identification and classification of high risk groups for Coal Workers' Pneumoconiosis using an artificial neural network based on occupational histories: a retrospective cohort study.",
        "abstract": "Coal workers' pneumoconiosis (CWP) is a preventable, but not fully curable occupational lung disease. More and more coal miners are likely to be at risk of developing CWP owing to an increase in coal production and utilization, especially in developing countries. Coal miners with different occupational categories and durations of dust exposure may be at different levels of risk for CWP. It is necessary to identify and classify different levels of risk for CWP in coal miners with different work histories. In this way, we can recommend different intervals for medical examinations according to different levels of risk for CWP. Our findings may provide a basis for further emending the measures of CWP prevention and control.The study was performed using longitudinal retrospective data in the Tiefa Colliery in China. A three-layer artificial neural network with 6 input variables, 15 neurons in the hidden layer, and 1 output neuron was developed in conjunction with coal miners' occupational exposure data. Sensitivity and ROC analyses were adapted to explain the importance of input variables and the performance of the neural network. The occupational characteristics and the probability values predicted were used to categorize coal miners for their levels of risk for CWP.The sensitivity analysis showed that influence of the duration of dust exposure and occupational category on CWP was 65% and 67%, respectively. The area under the ROC in 3 sets was 0.981, 0.969, and 0.992. There were 7959 coal miners with a probability value < 0.001. The average duration of dust exposure was 15.35 years. The average duration of ex-dust exposure was 0.69 years. Of the coal miners, 79.27% worked in helping and mining. Most of the coal miners were born after 1950 and were first exposed to dust after 1970. One hundred forty-four coal miners had a probability value > or =0.1. The average durations of dust exposure and ex-dust exposure were 25.70 and 16.30 years, respectively. Most of the coal miners were born before 1950 and began to be exposed to dust before 1980. Of the coal miners, 90.28% worked in tunneling.The duration of dust exposure and occupational category were the two most important factors for CWP. Coal miners at different levels of risk for CWP could be classified by the three-layer neural network analysis based on occupational history.",
        "keywords": [
            "occupational health",
            "exposure",
            "neural networks",
            "coal miners",
            "risk factors",
            "developing country",
            "neural network",
            "cohort study",
            "sensitivity analysis",
            "artificial neural network"
        ],
        "authors": [
            {
                "name": "Hongbo Liu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001, PR China|Department of Health Statistics, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001, PR China"
            },
            {
                "name": "Zhifeng Tang",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001, PR China"
            },
            {
                "name": "Yongli Yang",
                "org": "Division of Occupational Disease, General Hospital of Tiefa Colliery, Diaobingshan, Liaoning Province, 112700, PR China"
            },
            {
                "name": "Dong Weng",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001, PR China"
            },
            {
                "name": "Gao Sun",
                "org": "Department of Health Statistics, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001, PR China"
            },
            {
                "name": "Zhiwen Duan",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001, PR China"
            },
            {
                "name": "Jie Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001, PR China"
            }
        ],
        "venue": "BMC public health",
        "year": 2009
    },
    "u3oZH5SN": {
        "id": "u3oZH5SN",
        "title": "The effect of iodine deficiency and hypothyroidism on the protein expressions of ERK1/2 in the entorhinal cortex of pups",
        "abstract": "Objective To observe the effect of iodine deficiency and hypothyroidism on the protein expressions of ERK1 /2 in the entorhinal cortex of pups. Methods Female Wistar rats (n = 28) after pregenancy were randomly divided into control group,hypothyroid group and iodine deficient group. According to the dose of PTU in fed water,hypothyroid group was divided into 5ppm group and 15ppm group ( 7 in each ). 5 pups from each group were sacrificed and perfused intracardially in postnatal day (PN) 7,PN14,PN21,PN28 and PN42. Brains were removed,fixed and sectioned coronally. All sections were observated and analysed the protein exression of ERK1 /2 by immunohistochemistry in the entorhinal cortex. Results In PN14, PN21,PN28 and PN42,protein levels of ERK1 /2 in the entorhinal cortex in iodine-deficient,5ppm and 15ppm treatment groups were significantly lower than those of controls (P < 0. 05). In PN7,the protein expression was no significantly difference in all four groups. Conclusion Iodine deficiency and hypothyroidism may decrease the protein expression of ERK1 /2 in the entorhinal cortex of pups.",
        "keywords": [
            "Entorhinal cortex",
            "ERK1/2",
            "Iodine deficiency",
            "Hypothyroidism"
        ],
        "authors": [
            {
                "name": "WEI Wei",
                "org": "Department of Occupational and Environmental Health,School of Public Health, China Medical University,Shenyang Liaoning ,China"
            },
            {
                "name": "DONG Jing",
                "org": "Department of Occupational and Environmental Health,School of Public Health, China Medical University,Shenyang Liaoning ,China"
            },
            {
                "name": "WANG Yi",
                "org": "Department of Occupational and Environmental Health,School of Public Health, China Medical University,Shenyang Liaoning ,China"
            },
            {
                "name": "HOU Yi",
                "org": "Department of Occupational and Environmental Health,School of Public Health, China Medical University,Shenyang Liaoning ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Department of Occupational and Environmental Health,School of Public Health, China Medical University,Shenyang Liaoning ,China"
            }
        ],
        "venue": "Journal of Toxicology",
        "year": 2010
    },
    "LeBHoJgQ": {
        "id": "LeBHoJgQ",
        "title": "Dioscin Exerts Protective Effects Against Crystalline Silica-induced Pulmonary Fibrosis in Mice.",
        "abstract": "Inhalation of crystalline silica particles leads to pulmonary fibrosis, eventually resulting in respiratory failure and death. There are few effective drugs that can delay the progression of this disease; thus, patients with silicosis are usually only offered supportive care. Dioscin, a steroidal saponin, exhibits many biological activities and health benefits including its protective effects against hepatic fibrosis. However, the effect of dioscin on silicosis is unknown.We employed experimental mouse mode of silicosis. Different doses of dioscin were gavaged to the animals 1 day after crystalline silica instillation to see the effect of dioscin on crystalline silica induced pulmonary fibrosis. Also, we used RAW264.7 and NIH-3T3 cell lines to explore dioscin effects on macrophages and fibroblasts. Dioscin was also oral treatment but 10 days after crystalline silica instillation to see its effect on established pulmonary fibrosis.Dioscin treatment reduced pro-inflammation and pro-fibrotic cytokine secretion by modulating innate and adaptive immune responses. It also reduced the recruitment of fibrocytes, protected epithelial cells from crystalline silica injury, inhibited transforming growth factor beta/Smad3 signaling and fibroblast activation. Together, these effects delayed the progression of crystalline silica-induced pulmonary fibrosis. The mechanism by which dioscin treatment alleviated CS-induced inflammation appeared to be via the reduction of macrophage, B lymphocyte, and T lymphocte infiltration into lung. Dioscin inhibits macrophages and fibroblasts from secreting pro-inflammatory cytokines and may also function as a modulator of T helper cells responses, concurrent with attenuated phosphorylation of the apoptosis signal-regulating kinase 1-p38/c-Jun N-terminal kinase pathway. Also, dioscin could block the phosphorylation of Smad3 in fibroblast. Oral treatment of dioscin could also effectively postpone the progression of established silicosis.Oral treatment dioscin delays crystalline silica-induced pulmonary fibrosis and exerts pulmonary protective effects in mice. Dioscin may be a novel and potent candidate for protection against crystalline silica-induced pulmonary fibrosis.",
        "keywords": [
            "Crystalline silica",
            "Dioscin",
            "Epithelial cells",
            "Fibrocytes",
            "Immune response",
            "Natural products therapy.",
            "Pulmonary fibrosis"
        ],
        "authors": [
            {
                "name": "Chao Li",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Yiping Lu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Sitong Du",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Siyi Li",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Yiting Zhang",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Fangwei Liu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Ying Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Dong Weng",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Jie Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, PR China."
            }
        ],
        "venue": "Theranostics",
        "year": 2017
    },
    "bgBSIa4W": {
        "id": "bgBSIa4W",
        "title": "Developmental iodine deficiency resulting in hypothyroidism reduces hippocampal ERK1/2 and CREB in lactational and adolescent rats.",
        "abstract": "Developmental iodine deficiency (ID) leads to inadequate thyroid hormone that impairs learning and memory with an unclear mechanism. Here, we show that hippocampal extracellular signal-regulated kinase (ERK1/2) and cAMP response element-binding protein (CREB) are implicated in the impaired learning and memory in lactational and adolescent rat hippocampus following developmental ID and hypothyroidism.Three developmental rat models were created by administrating dam rats with either iodine-deficient diet or propylthiouracil (PTU, 5 ppm or 15 ppm)-added drinking water from gestational day (GD) 6 till postnatal day (PN) 28. Then, the total and phorsporylated ERK1/2 and total and phorsporylated CREB in the hippocampus were detected with western blot on PN14, PN21, PN28 and PN42.The iodine-deficient and hypothyroid pups showed lower serum FT3 and FT4 levels, smaller body size, and delayed eyes opening. The mean number of surviving cells in the hippocampus of the iodine-deficient and 15 ppm PTU-treated rats was significantly reduced compared to controls (P < 0.05). Iodine-deficient and 15 ppm PTU-treatment groups demonstrated significantly lower level of total and phosphorylated ERK1/2 and CREB than the controls on PN14, PN21 and PN28 (P < 0.05, respectively). The reduction of ERK1/2 and CREB was not reversible with the restoration of serum thyroid hormone concentrations on PN42.Developmental ID and hypothyroidism down-regulate hippocampal ERK1/2 and CREB in lactational and adolescent rats.",
        "keywords": [
            "camp response element binding protein",
            "neurobiology",
            "extracellular signal regulated kinase",
            "hippocampus",
            "iodine",
            "down regulation",
            "neurosciences",
            "cyclic amp"
        ],
        "authors": [
            {
                "name": "Jing Dong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China"
            },
            {
                "name": "Wanyang Liu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China"
            },
            {
                "name": "Yi Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China"
            },
            {
                "name": "Yi Hou",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China"
            },
            {
                "name": "Qi Xi",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China|Department of Physiology, Radboud University Nijmegen Medical Centre. Nijmegen, The Netherlands"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China"
            }
        ],
        "venue": "BMC neuroscience",
        "year": 2009
    },
    "QnbUBPe3": {
        "id": "QnbUBPe3",
        "title": "Effect of Congenital Iodine Deficiency on Protein Expressions of c-fos and c-jun in the Cerebellum of Rats",
        "abstract": "Objective To approach the mechanism of iodine and thyroid hormone action in brain development and to know whether congenital iodine deficiency may regulate the protein expressions of c-fos and c-jun in the cerebellum. Methods The female rats were randomly divided into two groups (10 in each): control group and iodine deficiency group. The dam rats in iodine deficient group were fed on iodine-deficient diet and deionized water, this treatment was started from one week before mated and was kept in the lactation until 30th postnatal day of newborn rats. Control group was treated with the normal diet and tap water during the whole experimental period. The body weight and thyoid hormone levels of newborn rats were tested and the protein expressions of c-fos and c-jun in cerebellum tissue were determined with SP immunohistochemical technique and micrograph analyses system on 20 th, 30 th and 60 th postnatal day (PN). Results The average of body weight and FT3 and FT4 in all the postnatal period were significantly decreased(P<0.01) and the protein expression of c-fos and c-jun on 20PN, 30PN and 60PN was also down regulated significantly (P<0.05) compared with the controls. Conclusion Iodine deficiency of mother rat may down regulate the protein expression of c-fos and c-jun of their offspring which may result in damage of cerebellum development.",
        "keywords": [
            "Rat",
            "c-fos",
            "Gene",
            "Iodine deficiency",
            "Cerebellum",
            "c-jun"
        ],
        "authors": [
            {
                "name": "JIANG Ying",
                "org": ", et al. Department of Occupational Health and Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning , China"
            },
            {
                "name": "CHEN Jie",
                "org": ", et al. Department of Occupational Health and Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning , China"
            },
            {
                "name": "LIU Wan-yang",
                "org": ", et al. Department of Occupational Health and Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning , China"
            }
        ],
        "venue": "Journal of Environment and Health",
        "year": 2006
    },
    "Omc1urBp": {
        "id": "Omc1urBp",
        "title": "Effects of iodine deficiency and hypothyroidism on the expression of calmodulin in hippocampus of pups",
        "abstract": "Objective To observe the effects of iodine deficiency and hypothyroidism on the expression of calmodulin in hippocampus of pups. Methods Female Wistar rats ( n = 28) after pregnancy were randomly divided into control group, hypothyroid group 1 and 2 and iodine-deficient group (7 in each group). From gestational day ( GD) 6 to postnatal day ( PN) 28,iodine-deficient group was administered with iodine-deficient diet and tap water; hypothyroid group 1 and 2 were administered 5 ppm and 15 ppm propylthiouracil ( PTU) in the drinking water and fed with normal diet. 5 pups from each group were sacrificed and intracardiac perfused in PN7,PN14 and PN21. Brains were removed,fixed and sectioned coronally. All sections were observed and analyzed the expression of calmodulin by immunohistochemistry in hippocampal CA1,CA3 and DG regions. Results In PN14 and PN21,the iodine deficiency and 15 ppm PTU-treatment significantly reduced calmodulin in hippocampal CA1 and CA3 regions (P < 0. 05),but not in DG region. In PN7,the positive products were scarcely observed in all regions and the expression was no significantly difference in all four groups. Conclusion Iodine deficiency and hypothyroidism may decrease the expressions of calmodulin in hippocampal CA1 and CA3 regions in pups.",
        "keywords": [
            "Hippocampus",
            "Iodine deficiency",
            "Calmodulin",
            "Hypothyroidism"
        ],
        "authors": [
            {
                "name": "DONG Jing",
                "org": "Department of Occupational and Environmental Health,School of Public Health,China Medical University,Shenyang Liaoning ,China"
            },
            {
                "name": "LIU Wan-yang",
                "org": "Department of Occupational and Environmental Health,School of Public Health,China Medical University,Shenyang Liaoning ,China"
            },
            {
                "name": "WANG Yi",
                "org": "Department of Occupational and Environmental Health,School of Public Health,China Medical University,Shenyang Liaoning ,China"
            },
            {
                "name": "WEI Wei",
                "org": "Department of Occupational and Environmental Health,School of Public Health,China Medical University,Shenyang Liaoning ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Department of Occupational and Environmental Health,School of Public Health,China Medical University,Shenyang Liaoning ,China"
            }
        ],
        "venue": "Journal of Toxicology",
        "year": 2010
    },
    "4ncmqnwn": {
        "id": "4ncmqnwn",
        "title": "Maternal Different Degrees of Iodine Deficiency during Pregnant and Lactation Impair the Development of Cerebellar Pinceau in Offspring.",
        "abstract": " Iodine is critical for synthesis of thyroid hormones (TH). And iodine deficiency (ID) is one of the most significant reasons of intellectual disability and motor memory impairment, although the potential mechanisms are still under investigation. Presently, mild ID and marginal ID are largely ignored problems for women of child bearing age. Mild ID is a subtle form of TH deficiency, which shows low levels of free thyroxine (FT) and relatively normal free triiodothyronine (FT) or thyroid stimulation hormone (TSH). And marginal ID is a milder form of ID with decreased total T (TT) but relatively normal FT, FT, and TSH. Therefore, we investigated the effects of maternal different degrees of ID on the development of pinceau in cerebellar purkinje cells (PCs) and studied the expression of pinceau related protein, which is crucial for the development and maturation of pinceau.  Three developmental iodine deficient rat models were created by feeding dam rats with an iodine-deficient diet and deionized water supplemented with potassiumiodide. Our study showed that different degrees of ID inhibited cerebellar pinceau synapse development and maturation on postnatal day (PN) 14 and PN21. What's more, mild and severe ID reduced the expression of AnkG, \u03b24-spectrin, neurofascin186 and NrCAM on PN7, PN14, and PN21. However, marginal ID rarely altered expression of these proteins in the offspring.  These results suggested that maternal mild and severe ID impaired the development and maturation of cerebellar pinceau, which may be attributed to the decrease of AnkG, \u03b24-spectrin, neurofascin 186, and NrCAM. And the alteration of development and maturation in cerebellar pinceau in the offspring were also observed following maternal marginal ID, which is slighter than that of mild ID.",
        "keywords": [
            "axon initial segment",
            "cerebellum",
            "iodine deficiency",
            "pinceau",
            "purkinje cells"
        ],
        "authors": [
            {
                "name": "Jing Dong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical UniversityShenyang, China."
            },
            {
                "name": "Heling Song",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical UniversityShenyang, China."
            },
            {
                "name": "Yuan Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical UniversityShenyang, China."
            },
            {
                "name": "Min Li",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical UniversityShenyang, China."
            },
            {
                "name": "Ye Yu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical UniversityShenyang, China."
            },
            {
                "name": "Yi Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical UniversityShenyang, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical UniversityShenyang, China."
            }
        ],
        "venue": "Frontiers in neuroscience",
        "year": 2017
    },
    "tItxcmqX": {
        "id": "tItxcmqX",
        "title": "IL-10-Producing CD1d hi CD5 + Regulatory B Cells May Play a Critical Role in Modulating Immune Homeostasis in Silicosis Patients.",
        "abstract": "Silicosis is characterized by chronic lung inflammation and fibrosis, which are extremely harmful to human health. The pathogenesis of silicosis involves uncontrolled immune processes. Evidence supports that regulatory B cells (Bregs) produce negative regulatory cytokines, such as IL-10, which can negatively regulate immune responses in inflammation and autoimmune diseases. Our previous study found that IL-10-producing B cells were involved in the development of silica-induced lung inflammation and fibrosis of mice. However, little is known about the role of Bregs in silicosis patients (SP). In this study, we found that serum concentrations of IL-10 were significantly increased in SP by using protein array screening. We further determined that the frequency of IL-10-producing CD1dCD5 Bregs, not IL-10-producing non-B lymphocytes, was significantly higher in SP compared to subjects under surveillance (SS) and healthy workers (HW) by flow cytometry. We also found that regulatory T cells (Tregs) and Th2 cytokines (IL-4, IL-5, and IL-13) were significantly increased in SP. Th1 cytokines (IFN-\u03b3, IL-2, and IL-12) and inflammatory cytokines (IL-1\u03b2, IL-6, and TNF-\u03b1) were not significantly different between SP, SS, and HW. Our study indicated that IL-10-producing CD1dCD5 Bregs might maintain Tregs and regulate Th1/Th2 polarization in SP, suggesting that IL-10-producing Bregs may play a critical role in modulating immune homeostasis in SP.",
        "keywords": [
            "IL-10",
            "Th1/Th2 polarization",
            "immune homeostasis",
            "regulatory B cells",
            "regulatory T cells",
            "silicosis patients"
        ],
        "authors": [
            {
                "name": "Ying Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University , Shenyang , China."
            },
            {
                "name": "Chao Li",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University , Shenyang , China."
            },
            {
                "name": "Yiping Lu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University , Shenyang , China."
            },
            {
                "name": "Huiying Zhuang",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University , Shenyang , China."
            },
            {
                "name": "Weijia Gu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University , Shenyang , China."
            },
            {
                "name": "Bo Liu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University , Shenyang , China."
            },
            {
                "name": "Fangwei Liu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University , Shenyang , China."
            },
            {
                "name": "Jinkai Sun",
                "org": "Department of Respiratory Medicine, Shenyang No. 9 Hospital , Shenyang , China."
            },
            {
                "name": "Bo Yan",
                "org": "Department of Respiratory Medicine, Shenyang No. 9 Hospital , Shenyang , China."
            },
            {
                "name": "Dong Weng",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China; Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China."
            },
            {
                "name": "Jie Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University , Shenyang , China."
            }
        ],
        "venue": "Frontiers in immunology",
        "year": 2017
    },
    "IVNG2LEu": {
        "id": "IVNG2LEu",
        "title": "Developmental Exposure to Di-(2-ethylhexyl) Phthalate Induces Cerebellar Granule Cell Apoptosis via the PI3K/AKT Signaling Pathway.",
        "abstract": "Di-(2-ethylhexyl) phthalate (DEHP) is an ubiquitous environmental contaminant because of its extensive use in plastics and its persistence. As an environmental endocrine disruptor, it is suspected to interfere with neurodevelopment in people. However, evidence of the effects of maternal DEHP exposure on cerebellar development in offspring is scarce. The objective of this study was to investigate maternal exposure to DEHP and its effect on apoptosis of cerebellar granule cells (CGCs) and related mechanisms. Pregnant Wistar rats were administrated DEHP (0, 30, 300 and 750 mg/kg/d) by gavage from gestational day (GD) 0 to postnatal day (PN) 21. Primary CGCs were also exposed to mono-(2-ethylhexyl) phthalate (MEHP), the main metabolite of DEHP, for 24 h with concentrations of 0, 25, 100 and 250 \u00b5M. The CGCs of male offspring from 300 and 750 mg/kg/d DEHP exposure groups showed significantly increased apoptosis. In addition, the PI3K/AKT signaling pathway was inhibited in the male offspring of the 300 and 750 mg/kg/d DEHP exposure groups. However, effects on female pups were not obvious. Apoptosis was also elevated and the PI3K/AKT signaling pathway was inhibited after primary CGCs were exposed to MEHP. Furthermore, apoptosis was reduced after treatment with the PI3K/AKT signaling pathway activator, insulin-like growth factor (IGF) 1, and increased after treatment with LY294002, an inhibitor of the PI3K/AKT signaling pathway. These results suggested that maternal DEHP exposure induced apoptosis in the CGCs of male pups via the PI3K/AKT signaling pathway, and the apoptosis could be rescued by IGF1 and aggravated by LY294002.",
        "keywords": [
            "Apoptosis",
            "Cerebellar granule cell",
            "DEHP",
            "PI3K/AKT signaling pathway"
        ],
        "authors": [
            {
                "name": "Yuanyuan Fu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110122, China."
            },
            {
                "name": "Jing Dong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110122, China."
            },
            {
                "name": "Jianan Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110122, China."
            },
            {
                "name": "Mingdan You",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110122, China."
            },
            {
                "name": "Lingling Wei",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110122, China."
            },
            {
                "name": "Hui Fu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110122, China."
            },
            {
                "name": "Yuan Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110122, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110122, China."
            }
        ],
        "venue": "Experimental neurobiology",
        "year": 2018
    },
    "TZSTGpcY": {
        "id": "TZSTGpcY",
        "title": "Baicalin Alleviates Silica-Induced Lung Inflammation and Fibrosis by Inhibiting the Th17 Response in C57BL/6 Mice.",
        "abstract": "Silicosis is an inflammatory and fibrotic lung disease caused by inhalation of silica. Th17 cells play a key role in causing silica-induced lung inflammation and fibrosis. Baicalin, a compound isolated from the Chinese herb Huangqin, could suppress the differentiation of Th17 cells and alleviate inflammation. However, there are very few reports of the immunoregulatory mechanisms of baicalin in experimental silica-induced lung inflammation and fibrosis. In our study, mice were exposed to silica by intratracheal instillation, and in this way we established an experimental silicosis model. To elucidate the effects and mechanisms of baicalin in silica-induced inflammation and fibrosis, we used baicalin to treat the developed mouse model of silicosis. Treatment with baicalin attenuated the accumulation of inflammatory cells and led to milder pathological inflammatory and fibrotic changes in lung tissues. Baicalin affected the immunological balance between Th17 and Treg responses. Therefore, baicalin caused a decrease in Th17 cells by stimulating Treg cells and by inhibiting IL-6 and IL-23. We further demonstrated that silica-induced Th1 and Th2 immune responses were both inhibited by increased Treg activation, which was promoted by baicalin. Our findings confirmed the potential functions of baicalin in inhibiting the Th17 response and reducing silica-induced inflammation and fibrosis.",
        "keywords": [],
        "authors": [
            {
                "name": "Tao Liu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, and \u2021Department of Natural Products Chemistry, School of Pharmacy, China Medical University , Shenyang 110122, People's Republic of China."
            },
            {
                "name": "Wujing Dai",
                "org": "Department of Occupational and Environmental Health, School of Public Health, and \u2021Department of Natural Products Chemistry, School of Pharmacy, China Medical University , Shenyang 110122, People's Republic of China."
            },
            {
                "name": "Chao Li",
                "org": "Department of Occupational and Environmental Health, School of Public Health, and \u2021Department of Natural Products Chemistry, School of Pharmacy, China Medical University , Shenyang 110122, People's Republic of China."
            },
            {
                "name": "Fangwei Liu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, and \u2021Department of Natural Products Chemistry, School of Pharmacy, China Medical University , Shenyang 110122, People's Republic of China."
            },
            {
                "name": "Ying Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Health, and \u2021Department of Natural Products Chemistry, School of Pharmacy, China Medical University , Shenyang 110122, People's Republic of China."
            },
            {
                "name": "Dong Weng",
                "org": "Department of Occupational and Environmental Health, School of Public Health, and \u2021Department of Natural Products Chemistry, School of Pharmacy, China Medical University , Shenyang 110122, People's Republic of China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Health, and \u2021Department of Natural Products Chemistry, School of Pharmacy, China Medical University , Shenyang 110122, People's Republic of China."
            }
        ],
        "venue": "Journal of natural products",
        "year": 2015
    },
    "1HLqaSav": {
        "id": "1HLqaSav",
        "title": "Investigation of the Incidence of CWP in a Coal Mine of Tiefa Coal Group",
        "abstract": "Objective To explore the incidence of CWP and its developing trend in a coal mine of Tiefa Coal Group,and to provide scientific criteria for reinforcing its prevention and management.Methods Coal miners exposed to dust over 1 year since the foundation of the mine were investigated.Life table method was used to analyze the dust exposure years,job categories,and the distribution and difference of cumulative incidence rates in different exposure era.Results There were 4888 miners exposed to dust over 1a.Among them 4747 miners exposed to dust without pneumoconiosis,60 miners were diagnosed as CWP,and 81 miners were missed in the follow-up.Results showed that among the miners the longer the exposure years were,the higher the cumulative incidence of CWP would be.The cumulative incidences of CWP in miners whose exposure years were >30a,20~30a,and <20a were 33.6%,9.1% and 5.5% respectively,the difference was significant(P<0.05).The cumulative incidence of tunnelers(17.8%) was statistically higher than that of mining miners(2.9%) and that of mixed miners(3.0%),(P<0.01).The cumulative incidence rates of miners exposed to dust prior to 1965,during 1965~1975,and after 1975 were 3.8%,1.8% and 0.1% respectively(P<0.05).Conclusions The cumulative incidence rate of CWP in this mine declines as the dust exposure era shifts nearer.The cumulative incidence of CWP is the highest among those who have a longer history of dust exposure and engaging in tunneling work.",
        "keywords": [
            "Coal workers' pneumoconiosis(CWP)",
            "Incidence rate",
            "Life table method"
        ],
        "authors": [
            {
                "name": "TIAN Lu-jia",
                "org": "* School of Public Health,China Medical University,Shenyang  China"
            },
            {
                "name": "LIU Hong-bo",
                "org": "* School of Public Health,China Medical University,Shenyang  China"
            },
            {
                "name": "YANG Yong-li",
                "org": "* School of Public Health,China Medical University,Shenyang  China"
            },
            {
                "name": "TANG Zhi-feng",
                "org": "* School of Public Health,China Medical University,Shenyang  China"
            },
            {
                "name": "WENG Dong",
                "org": "* School of Public Health,China Medical University,Shenyang  China"
            },
            {
                "name": "CHEN Jie",
                "org": "* School of Public Health,China Medical University,Shenyang  China"
            }
        ],
        "venue": "Industrial Health and Occupational Diseases",
        "year": 2009
    },
    "R2fDzeXS": {
        "id": "R2fDzeXS",
        "title": "Negative control of TLR3 signaling by TICAM1 down-regulation.",
        "abstract": "Toll-IL-1 receptor (TIR) domain-containing adaptor molecule-1 (TICAM1, also called TRIF) is an important adaptor protein in TLR3 and TLR4 signaling pathways that mediate proinflammatory cytokine and IFN responses. Negative regulation of TICAM1 by exogenous viral protease or by endogenous caspase and proteasome have been reported to shut down TICAM1-mediated signaling. In this study, we discovered that down-regulation of TICAM1, but not other components in this signaling pathway, occurred in a natural process of TLR3 activation induced by double-stranded RNA or human rhinovirus (RV) infection in airway epithelial cells and various other cell types. TICAM1 was essential for IFN expression, and the loss of TICAM1 significantly elevated RV production. The low level of TICAM1 protein expression, caused by the prior double-stranded RNA treatment, led to a lack of IFN production upon additional treatment, suggesting receptor desensitization. In follow-up studies, TICAM1 down-regulation was found to be dependent on TLR3 but not RIG1, MDA5, or PKR and appeared to be regulated post-translationally. Neither proteasome nor caspase inhibitors could prevent TICAM1 down-regulation. Instead, a lysosome-mediated process appeared to be involved, suggesting a novel mechanism that is different from previous reports. In conclusion, TICAM1 down-regulation is an essential step in TLR3 activation, and its function is to stop TLR3-mediated IFN production.",
        "keywords": [
            "airway",
            "tlr3",
            "desensitization",
            "ticam1",
            "virus",
            "down regulation",
            "signal transduction",
            "real time polymerase chain reaction",
            "flow cytometry",
            "dna primers"
        ],
        "authors": [
            {
                "name": "Shasha Tao",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Lingxiang Zhu",
                "org": "University of Arizona(University of Arizona),Tucson,United States"
            },
            {
                "name": "Pakkei Lee",
                "org": "The Hamner Institutes for Health Research(The Hamner Institutes for Health Research,Hamner Institutes for Health Research),Durham,United States"
            },
            {
                "name": "Wai-ming Lee",
                "org": "University of Wisconsin Madison(University of Wisconsin-Madison),Madison,United States"
            },
            {
                "name": "Kenneth Knox",
                "org": "University of Arizona(University of Arizona),Tucson,United States"
            },
            {
                "name": "Jie Chen",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Yuanpu Peter Di",
                "org": "University of Pittsburgh(University of Pittsburgh),Pittsburgh,United States"
            },
            {
                "name": "Yin Chen",
                "org": "University of Arizona(University of Arizona),Tucson,United States"
            }
        ],
        "venue": "American journal of respiratory cell and molecular biology",
        "year": 2012
    },
    "xswrR12F": {
        "id": "xswrR12F",
        "title": "Developmental Iodine Deficiency and Hypothyroidism Impair Neural Development, Upregulate Caveolin-1, and Downregulate Synaptotagmin-1 in the Rat Cerebellum",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "j zhong",
                "org": "china medical university"
            },
            {
                "name": "wei wei",
                "org": "china medical university"
            },
            {
                "name": "jian gong",
                "org": "china medical university"
            },
            {
                "name": "jing dong",
                "org": "china medical university"
            },
            {
                "name": "fei yu",
                "org": "china medical university"
            },
            {
                "name": "yuan wang",
                "org": "china medical university"
            },
            {
                "name": "jie chen",
                "org": "china medical university"
            }
        ],
        "venue": "Biological Trace Element Research",
        "year": 2011
    },
    "EInZYZ09": {
        "id": "EInZYZ09",
        "title": "Dihydrotanshinone I Alleviates Crystalline Silica-Induced Pulmonary Inflammation by Regulation of the Th Immune Response and Inhibition of STAT1/STAT3.",
        "abstract": "Occupational exposure to crystalline silica (CS) results in a persistent pulmonary inflammatory response that eventually leads to abnormal tissue repair, disability, and death. The inflammatory-immune responses occur in the early stages of CS exposure, and both innate and adaptive immunity are involved. CD4+ T cells play a pivotal role in the pathogenesis of CS-induced pulmonary disease, which has no proven curative therapy. Dihydrotanshinone I (DHI), a natural product isolated from Salvia miltiorrhiza Bunge (Danshen), has anti-inflammatory and immunomodulatory properties. However, whether DHI has a protective effect on CS-induced lung disease, how it influences the Th immune response, and the potential underlying molecular mechanism(s) have not been fully clarified. In this study, DHI treatment of CS-exposed mice reduced the expression of proinflammatory cytokines and the infiltration of immune cells. It significantly ameliorated CS-induced pulmonary inflammation by attenuating T helper (Th)1 and Th17 responses, which were tightly related to the inhibition of STAT1 and STAT3. DHI significantly altered Th2 cytokines but not the Th2 nuclear transcription factor. Furthermore, our study found that DHI treatment also affected regulatory T cell activity in CS-injured mice. Taken together, our findings indicated that DHI could modulate Th responses and alleviate CS-induced pulmonary inflammation, suggesting a novel application of DHI in CS-induced pulmonary disease.",
        "keywords": "",
        "authors": [
            {
                "name": "Yiting Zhang",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Chao Li",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Siyi Li",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Yiping Lu",
                "org": "Biobank, The Affiliated Shengjing Hospital, China Medical University, Shenyang, China."
            },
            {
                "name": "Sitong Du",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Xinning Zeng",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Xi Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Jie Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            }
        ],
        "venue": "Mediators of inflammation",
        "year": 2019
    },
    "TbmzLWgL": {
        "id": "TbmzLWgL",
        "title": "Comparing study of the effect of nanosized silicon dioxide and microsized silicon dioxide on fibrogenesis in rats.",
        "abstract": "This study compares the effect of nanosized silicon dioxide (nanosized SiO2) and microsized silicon dioxide (microsized SiO2) particles on fibrogenesis in rats. Wistar rats were instilled intratracheally with saline, 20 mg of nanosized SiO2 or 20 mg of microsized SiO2, and were sacrificed at 1 and 2 months after instillation. The lungs of rats were analysed for the changes of lung/body coefficient and hydroxyproline content. Changes in pathology and fibrotic grade were observed by use of hematoxylin and eosin and Van Gieson dyeing. The expression of interleukin-4 (IL-4) and transforming growth factor-beta1 (TGF-beta1) was observed by use of immunohistochemical technique, and protein expression quantitatively analysed by image analysis. The lung/body coefficient and hydroxyproline content of nanosized SiO2 groups were significantly lower than those of microsized SiO2 groups at both 1 and 2 months after instillation (P<0.05 or P<0.01), but without significant differences from those of saline control groups. At 1 month after instillation, there were mainly cellular nodules (Stage I) in nanosized SiO2 group, while in microsized SiO2 group Stage II, II+ of silicotic nodules were observed. At 2 months after instillation, there were still Stage I of silicotic nodules in nanosized SiO2 group. In microsized SiO2 group mainly Stage II+, III of silicotic nodules were found. Quantity image analysis showed that the expressions of IL-4 and TGF-beta1 in nanosized SiO2 groups were significantly lower than those in microsized SiO2 groups (P<0.01), but without significant difference from those of saline control groups. Our experiment revealed that the effect of fibrogenesis of nanosized SiO2 might be milder than that of microsized SiO2 in rats, potentially resulting from nanoparticals tending to be diffused and easily translocated due to their ultrafine particle size compared to microsized particles.",
        "keywords": [
            "lung fibrosis",
            "microsized silicon dioxide",
            "nanosized silicon dioxide",
            "rats"
        ],
        "authors": [
            {
                "name": "Ying Chen",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Jing Dong",
                "org": ""
            },
            {
                "name": "Yihe Jin",
                "org": ""
            }
        ],
        "venue": "Toxicology and industrial health",
        "year": 2004
    },
    "VoNwgtP7": {
        "id": "VoNwgtP7",
        "title": "Maternal exposure to nonylphenol during pregnancy and lactation induces microglial cell activation and pro-inflammatory cytokine production in offspring hippocampus.",
        "abstract": "Recently, environmental nonylphenol (NP) exposure in the fetus and child has received increasing attention because of its potentially deleterious effects on the central nervous system (CNS). Microglia (MG), resident immune cells in the CNS, are vital to CNS homeostasis and defense against exogenous chemicals, which makes them a potentially sensitive target of NP. The present study aims to explore the effects of maternal NP exposure during pregnancy and lactation on MG in offspring hippocampus, the production of pro-inflammatory cytokines by MG, and associated underlying mechanisms. We found that maternal NP exposure increased the production of interleukin-1\u03b2 (IL-1\u03b2), interleukin-6 (IL-6), and tumor necrosis factor-\u03b1 (TNF-\u03b1) in offspring hippocampus. Increases in both activation and number of MG were observed in offspring hippocampus. Increased phosphorylation of Akt was found to co-localize with hippocampal MG, while increased phosphorylation of c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) were observed in offspring hippocampus. Activator protein 1 (AP-1), an inflammatory transcription factor, was also activated in the hippocampus of pups subjected to maternal NP exposure. These results suggest that maternal NP exposure might activate MG in offspring hippocampus. This activation seems to subsequently increase the production of IL-1\u03b2, IL-6, and TNF-\u03b1. Furthermore, Akt/MAPK/AP-1 signaling may be involved in this activation of MG and increased production of pro-inflammatory cytokines.",
        "keywords": [
            "MAP kinase",
            "Microglia",
            "Nonylphenol",
            "Pro-inflammatory cytokines"
        ],
        "authors": [
            {
                "name": "Weijia Gu",
                "org": "Department of Occupational and Environmental Health, School of Public Heath, China Medical University, PR China."
            },
            {
                "name": "Yi Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Heath, China Medical University, PR China."
            },
            {
                "name": "Zhenmin Qiu",
                "org": "Department of Occupational and Environmental Health, School of Public Heath, China Medical University, PR China."
            },
            {
                "name": "Jing Dong",
                "org": "Department of Occupational and Environmental Health, School of Public Heath, China Medical University, PR China."
            },
            {
                "name": "Yuan Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Heath, China Medical University, PR China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Heath, China Medical University, PR China. Electronic address: Jchen@cmu.edu.cn."
            }
        ],
        "venue": "The Science of the total environment",
        "year": 2018
    },
    "TVQb2nzi": {
        "id": "TVQb2nzi",
        "title": "Synthesis of Mouse CD36 Gene Segments and Expression and Purification of their Coding Protein Infused with GST",
        "abstract": "Objective To obtain mouse CD36 segments that express efficiently in E.coli BL21 and purify the target proteins. Methods CD36 gene segments were designed and synthesized. After sequenced,the reconstructed expression vectors were constructed by enzyme digestion and cloning into expression vector pGEX-5X-2. Then the reconstructed vectors were transformed into E.coli BL21. Recombinant GST fusion proteins were expressed via the induction of IPTG and purified through GST affinity columns. Results The sequences of cloned mouse CD36 gene segments were identical with GenBank reported. A protein band of 28.5 kDa appeared on SDS-PAGE gel after the expressed GST fusion proteins were separated by SDS-PAGE. Then the expressed fusion proteins were purified to high purity. Conclusion The mouse CD36 gene segments have been synthesized and efficiently expressed in E.coli BL21,and the GST fused target proteins have been purified to high purity.",
        "keywords": [
            "expression",
            "purification",
            "gene synthesis",
            "CD36 gene"
        ],
        "authors": [
            {
                "name": "WANG Xin",
                "org": "Division of Pneumoconiosis,College of Public Health,China Medical University,Shenyang ,China"
            },
            {
                "name": "CHEN Ying",
                "org": "Division of Pneumoconiosis,College of Public Health,China Medical University,Shenyang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Division of Pneumoconiosis,College of Public Health,China Medical University,Shenyang ,China"
            }
        ],
        "venue": "Journal of China Medical University",
        "year": 2008
    },
    "gERk3us3": {
        "id": "gERk3us3",
        "title": "Blocking the 4-1BB Pathway Ameliorates Crystalline Silica-induced Lung Inflammation and Fibrosis in Mice.",
        "abstract": "Long term pulmonary exposure to crystalline silica leads to silicosis that manifests progressive interstitial fibrosis, eventually leading to respiratory failure and death. Despite efforts to eliminate silicosis, clinical cases continue to occur in both developing and developed countries. The exact mechanisms of crystalline silica-induced pulmonary fibrosis remain elusive. Herein, we find that 4-1BB is induced in response to crystalline silica injury in lungs and that it is highly expressed during development of experimental silicosis. Therefore, we explore the role of 4-1BB pathway during crystalline silica-induced lung injury and find that a specific inhibitor blocking the pathway could effectively alleviate crystalline silica-induced lung inflammation and subsequent pulmonary fibrosis in vivo. Compared to controls, the treated mice exhibited reduced Th1 and Th17 responses. The concentrations of pro-inflammatory cytokines in bronchoalveolar lavage fluid (BALF), including tumor necrosis factor (TNF)-\u03b1, interferon (IFN)-\u03b3 and interleukin (IL)-17A following crystalline silica challenge were also reduced in inhibitor-treated mice. Although there was no significant alteration in Th2 cytokines of IL-4 and IL-13, another type of pro-fibrogenic cell, regulatory T cell (Treg) was significantly affected. In addition, one of the major participants in fibrogenesis, fibrocyte recruited less due to the blockade. Furthermore, we demonstrated the decreased fibrocyte recruitment was associated with chemokine reductions in lung. Our study discovers the 4-1BB pathway signaling enhances inflammatory response and promotes pulmonary fibrosis induced by crystalline silica. The findings here provide novel insights into the molecular events that control crystalline silica-induced lung inflammation and fibrosis through regulating Th responses and the recruitment of fibrocytes in crystalline silica-exposed lung.",
        "keywords": "",
        "authors": [
            {
                "name": "Chao Li",
                "org": ""
            },
            {
                "name": "Sitong Du",
                "org": ""
            },
            {
                "name": "Yiping Lu",
                "org": ""
            },
            {
                "name": "Xiaowei Lu",
                "org": ""
            },
            {
                "name": "Fangwei Liu",
                "org": ""
            },
            {
                "name": "Ying Chen",
                "org": ""
            },
            {
                "name": "Dong Weng",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Theranostics",
        "year": 2016
    },
    "qUqBZZRv": {
        "id": "qUqBZZRv",
        "title": "Different Degrees of Iodine Deficiency Inhibit Differentiation of Cerebellar Granular Cells in Rat Offspring, via BMP-Smad1/5/8 Signaling.",
        "abstract": "Iodine deficiency (ID) during development results in dysfunction of the central nervous system (CNS) and affects psychomotor and motor function. It is worth noting that maternal mild and marginal ID tends to be the most common reason of preventable neurodevelopmental impairment, via a mechanism that has not been elucidated. Therefore, our aim was to study the effects of developmental mild and marginal ID on the differentiation of cerebellar granule cells (GCs) and investigate the activation of BMP-Smad1/5/8 signaling, which is crucial for the development and differentiation of cerebellum. Three developmental rat models were created by feeding dam rats with a diet deficient in iodine and deionized water supplemented with potassium iodide. Our results showed that different degrees of ID inhibited and delayed the differentiation of cerebellar GCs on postnatal day (PN) 7, PN14, and PN21. Moreover, mild and severe ID reduced the expression of BMP2 and p-Smad1/5/8, and increased the levels of Id2 on PN7, PN14, and PN21. However, marginal ID rarely altered expression of these proteins in the offspring. Our study supports the hypothesis that mild and severe ID during development inhibits the differentiation of cerebellar GCs, which may be ascribed to the down-regulation of BMP-Smad1/5/8 signaling and the overexpression of Id2. Furthermore, it was speculated that maternal marginal ID rarely affected the differentiation of cerebellar GCs in the offspring. ",
        "keywords": [
            "BMP-Smad1/5/8 signaling",
            "Cerebellum",
            "Differentiation",
            "Granular cells",
            "Id2",
            "Marginal iodine deficiency",
            "Mild iodine deficiency"
        ],
        "authors": [
            {
                "name": "jing dong",
                "org": "china medical university"
            },
            {
                "name": "xibing lei",
                "org": "china medical university"
            },
            {
                "name": "yuan wang",
                "org": "china medical university"
            },
            {
                "name": "heling song",
                "org": "china medical university"
            },
            {
                "name": "min li",
                "org": "china medical university"
            },
            {
                "name": "hui min",
                "org": "china medical university"
            },
            {
                "name": "ye yu",
                "org": "china medical university"
            },
            {
                "name": "qi xi",
                "org": "university of tennessee health science center"
            },
            {
                "name": "weiping teng",
                "org": "china medical university"
            },
            {
                "name": "jie chen",
                "org": "china medical university"
            }
        ],
        "venue": "Molecular neurobiology",
        "year": 2015
    },
    "n9NmcC7e": {
        "id": "n9NmcC7e",
        "title": "Associations of urinary di-(2-ethylhexyl) phthalate metabolites with the residential characteristics of pregnant women.",
        "abstract": "Epidemiological evidence on the associations between urinary di-(2-ethylhexyl) phthalate (DEHP) metabolites and residential characteristics is limited. Therefore, we investigated the associations of urinary DEHP metabolites with the residential characteristics of pregnant women. We collected completed questionnaires and maternal spot urine samples from 616 random pregnant women in Shengjing Hospital of China Medical University in Shenyang. Urinary DEHP metabolites concentrations, including mono-(2-ethylhexyl) phthalate (MEHP) and mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), were measured and analyzed by Gas Chromatography-Mass Spectrometry (GC-MS). Multivariable linear regression models were performed to obtain regression estimates (\u03b2) and 95% confidence intervals (CIs) after adjustment for sociodemographic characteristics. In all participants, the geometric mean of MEHP and MEHHP concentrations were 4.25\u00a0\u00b1\u00a04.34 and 5.72\u00a0\u00b1\u00a02.65\u00a0\u03bcg/L, respectively. In multivariable analyses after adjusting for sociodemographic characteristics, distance from residence to motor vehicle traffic (\u2265150\u00a0m versus <20\u00a0m) was negatively associated with MEHP (\u03b2\u00a0=\u00a0-0.241, 95% CI: -0.448, -0.033) and MEHHP (\u03b2\u00a0=\u00a0-0.279, 95% CI: -0.418, -0.140) concentrations. Compared with the one that had not recently been renovated, a renovated home was associated with higher MEHP (\u03b2\u00a0=\u00a00.194, 95% CI: 0.064, 0.324) and MEHHP (\u03b2\u00a0=\u00a00.111, 95% CI: 0.024, 0.197) concentrations. Air freshener use was associated with higher MEHP (\u03b2\u00a0=\u00a00.322, 95% CI: 0.007, 0.636) concentrations. Moldy walls were positively associated with MEHP (\u03b2\u00a0=\u00a00.299, 95% CI: 0.115, 0.482) and MEHHP (\u03b2\u00a0=\u00a00.172, 95% CI: 0.050, 0.294) concentrations. In contrast, humidifier use was associated with a lower MEHP concentration (\u03b2\u00a0=\u00a0-0.167, 95% CI: -0.302, -0.032). Residential characteristics were probably associated with the DEHP exposure of pregnant women in Shenyang. Living near the motor vehicle traffic, residential renovation, air freshener use, and moldy walls are likely risk factors for increased DEHP exposure, whereas using household humidifier could be considered a protective measure to reduce DEHP exposure.",
        "keywords": [
            "DEHP exposure",
            "Humidifier",
            "Pregnant women",
            "Residential characteristics"
        ],
        "authors": [
            {
                "name": "Jing Dong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, PR China."
            },
            {
                "name": "Yanan Ma",
                "org": "Department of Biostatistics and Epidemiology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, PR China."
            },
            {
                "name": "Kunkun Leng",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, PR China."
            },
            {
                "name": "Lingling Wei",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, PR China."
            },
            {
                "name": "Ying Wang",
                "org": "Department of Gynaecology and Obstetrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, PR China."
            },
            {
                "name": "Chang Su",
                "org": "Yale School of Medicine, New Haven, CT, USA."
            },
            {
                "name": "Ming Liu",
                "org": "Bioinformatics and Computational Biology Program, Worcester Polytechnic Institute, Worcester, MA, USA."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, PR China. Electronic address: jchen@cmu.edu.cn."
            }
        ],
        "venue": "The Science of the total environment",
        "year": 2019
    },
    "oglaFruu": {
        "id": "oglaFruu",
        "title": "Experimental study on fibrogenic effect of fur dust on rat lung.",
        "abstract": "The fibrogenicity of fur dust was studied in rat lung tissues.Intratracheal instillation of fur dust, morphologic examination of lungs and analysis of collagen content were performed in Wistar rats.Morphologic examination revealed that the earliest changes consisted of alveolar edema, increased numbers of intraalveolar macrophages, and marked thickening of interalveolar septa with mixed cellular infiltrate. After sixth months, there was moderate thickening of the alveolar walls and the peribronchioli. After 12 months, interstitial positive fibrosis of the alveolar wall and the peribronchioli were weakly seen. In the carding dust group (silica content 17.6%), interstitial nodules were observed composed of fibroblasts, reticular fibers, and collagen fibers. Electron microscopic examination also showed that alveolar walls became thickened and collagen fiber bundles were seen around bronchioles and small vessels in the carding groups after 12 months. At all stages of analysis, the collagen content in lungs of the fur dust groups was significantly higher than that of the control group.Our study suggested that fur dust might induce weak interstitial fibrosis in the lung.",
        "keywords": [
            "lung interstitial fibrosis",
            "fur dust",
            "experimental study",
            "control group",
            "bioinformatics",
            "biomedical research",
            "electron microscope"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Division of Pneumoconiosis,School of Public Health, China Medical University,China"
            },
            {
                "name": "Yongli Cui",
                "org": "Division of Pneumoconiosis,School of Public Health, China Medical University,China"
            },
            {
                "name": "Yingchun Sun",
                "org": "Division of Pneumoconiosis,School of Public Health, China Medical University,China"
            },
            {
                "name": "Jiezhi Lou",
                "org": "Division of Pneumoconiosis,School of Public Health, China Medical University,China"
            },
            {
                "name": "Zhenlin Liu",
                "org": "Division of Pneumoconiosis,School of Public Health, China Medical University,China"
            }
        ],
        "venue": "Environmental health and preventive medicine",
        "year": 2003
    },
    "SYt29Hwy": {
        "id": "SYt29Hwy",
        "title": "Study of Fibrosis Inhibition in Silicotic Mice by CD36 Synthetic Peptide",
        "abstract": "Objective To observe the inhibitory effect of CD36 synthetic peptide(93-110)on fibrosis of silicotic mice.Methods Mice were randomly divided into four groups:the saline control group,SiO2 model group,CD36(93-110)group and CD36(208-225)group.6~8 mice of each group were sacrificed after 7,14 and 21 days respectively after instillation.Pathomorphology of silicotic lungs was observed using hematoxylin eosin(HE)and van Gieson stains(VG)dyeing.Changes of hydroxyproline contents in pulmonary tissue were measured.Results The inflammatory or fibrotic lesion in the lungs of CD36(93-110)group was lower than that of CD36(208-225)group.The hydroxyproline contents of four groups at 7 days after the instillations had no significant differences.The fibrotic degree in silicotic mice lungs and hydroxyproline contents of pulmonary tissue were much lower in CD36 synthetic peptide treated group than those of SiO2 model group and CD36 control peptide group at 14 d and 21 d(P<0.05).Conclusions CD36 synthetic peptide(93-110)might have obvious inhibitory effect on lung fibrosis in silicosis mice.",
        "keywords": [
            "Hydroxyproline",
            "CD36",
            "Synthetic peptide",
            "Lung fibrosis"
        ],
        "authors": [
            {
                "name": "LV Li-na",
                "org": "School of Public Health,China Medical University,Shenyang  China"
            },
            {
                "name": "WANG Xin",
                "org": "School of Public Health,China Medical University,Shenyang  China"
            },
            {
                "name": "CHEN Ying",
                "org": "School of Public Health,China Medical University,Shenyang  China"
            },
            {
                "name": "LIU Fang-wei",
                "org": "School of Public Health,China Medical University,Shenyang  China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Public Health,China Medical University,Shenyang  China"
            }
        ],
        "venue": "Industrial Health and Occupational Diseases",
        "year": 2010
    },
    "D321WUAB": {
        "id": "D321WUAB",
        "title": "Effect of Iodine Deficiency and Hypothyroidism on the Protein Expressions of Calcineurin in the Hippocampus of Pups",
        "abstract": "Objective To observe the effect of iodine deficiency and hypothyroidism on the protein expressions of calcineurin in the hip-pocampus of pups. Methods Female Wistar rats(n=28)after pregenancy were randomly divided into control group,hypothyroid group and iodine deficient group. According to the dose of propylthiouracil (PTU)in the fed water,hypothyroid group was divided into 5 ppm group and 15 ppm group(7 rats in each group). Totally 5 pups from each group were sacrificed and perfused intracardially in postnatal day(PN) 7,PN14 and PN21. Brains were removed,fixed and sectioned coronally. All sections were observed and analysed for the protein exression of calcineurin by immunohistochemistry in the hippocampus CA1,CA3 and DG regions. Results In PN14 and PN21,protein levels of cal-cineurin in CA1 and CA3 regions of the hippocampus in iodine-deficient and 15 ppm treatment groups were significantly higher than those of the controls (P < 0.05)and in DG region,the contrary was true. In PN7,the positive products were scarely observated in each region and the protein expression was no significantly different in all four groups. Conclusion Iodine deficiency and hypothyroidism may increase the protein expression of calcineurin.",
        "keywords": [
            "calcineurin",
            "hypothyroidism",
            "hippocampus",
            "iodine deficiency",
            "thyroid gland",
            "iodine"
        ],
        "authors": [
            {
                "name": "WANG Yi",
                "org": "Department of Occupational and Environmental Health,School of Public Health,China Medical University,Shenyang ,China"
            },
            {
                "name": "DONG Jing",
                "org": "Department of Occupational and Environmental Health,School of Public Health,China Medical University,Shenyang ,China"
            },
            {
                "name": "LIU Wan-yang",
                "org": "Department of Occupational and Environmental Health,School of Public Health,China Medical University,Shenyang ,China"
            },
            {
                "name": "WEI Wei",
                "org": "Department of Occupational and Environmental Health,School of Public Health,China Medical University,Shenyang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Department of Occupational and Environmental Health,School of Public Health,China Medical University,Shenyang ,China"
            }
        ],
        "venue": "Journal of China Medical University",
        "year": 2009
    },
    "Jp8GqRZM": {
        "id": "Jp8GqRZM",
        "title": "Lipopolysaccharides may aggravate apoptosis through accumulation of autophagosomes in alveolar macrophages of human silicosis.",
        "abstract": "Silica dust mainly attacks alveolar macrophages (AMs) and increases the apoptosis of AMs in silicosis patients. However, it is still unclear whether autophagy is affected. Autophagy mainly has defensive functions in response to stress, contributing to cell survival in adverse conditions, and conversely it has also been implicated in cell death. Lipopolysaccharide (LPS) is able to induce autophagy and apoptosis in macrophages. The role of LPS in autophagy and apoptosis in AMs of silicosis patients is unknown. In this study, we collected AMs from 53 male workers exposed to silica and divided them into an observer (control) group, and stage I, II and III patient groups. We found increased levels of LC3B, SQSTM1/p62 and BECN1, whereas the phosphorylation of MTOR, and levels of LAMP2, TLR4, MYD88, TICAM1, as well as the number of lysosomes decreased with the development of silicosis. LPS stimulation triggered autophagy and increased levels of SQSTM1 in AMs. The autophagy inhibitor, 3-methyladenine (3MA), inhibited LPS-induced apoptosis in the AMs of silicosis patients. Moreover, 3 MA reversed the LPS-induced decrease in BCL2 and the increase in BAX and CASP3 levels in AMs. These results suggest that autophagosomes accumulate in AMs during silicosis progression. LPS can induce the formation of autophagosomes through a TLR4-dependent pathway, and LPS may exacerbate the apoptosis in AMs. Blockade of the formation of autophagosomes may inhibit LPS-induced apoptosis via the intrinsic apoptotic pathway in AMs. These findings describe novel mechanisms that may lead to new preventive and therapeutic strategies for pulmonary fibrosis.",
        "keywords": [
            "Alveolar macrophages",
            "Apoptosis",
            "Autophagic degradation",
            "Autophagosome",
            "Autophagy",
            "LPS",
            "Lysosome",
            "Silicosis",
            "TLR4"
        ],
        "authors": [
            {
                "name": "Shi Chen",
                "org": "a School of Public Health, China Medical University , Shenyang , China."
            },
            {
                "name": "Juxiang Yuan",
                "org": "b School of Public Health, North China University of Science and Technology , Tangshan , China."
            },
            {
                "name": "Sanqiao Yao",
                "org": "c School of Public Health, Xinxiang Medical University , Xinxiang , China."
            },
            {
                "name": "Yulan Jin",
                "org": "b School of Public Health, North China University of Science and Technology , Tangshan , China."
            },
            {
                "name": "Gang Chen",
                "org": "d Department of Pneumoconiosis , Beidaihe Sanitarium for China Coal Miners , Beidaihe , China."
            },
            {
                "name": "Wei Tian",
                "org": "e Heart Institute, North China University of Science and Technology , Tangshan , China."
            },
            {
                "name": "Jinkun Xi",
                "org": "e Heart Institute, North China University of Science and Technology , Tangshan , China."
            },
            {
                "name": "Zhelong Xu",
                "org": "e Heart Institute, North China University of Science and Technology , Tangshan , China."
            },
            {
                "name": "Dong Weng",
                "org": "a School of Public Health, China Medical University , Shenyang , China."
            },
            {
                "name": "Jie Chen",
                "org": "a School of Public Health, China Medical University , Shenyang , China."
            }
        ],
        "venue": "Autophagy",
        "year": 2015
    },
    "M74IrBhg": {
        "id": "M74IrBhg",
        "title": "Treg cells may regulate interlukin-17 production by modulating TH1 responses in 1,3-\u03b2-glucan-induced lung inflammation in mice",
        "abstract": "1,3-\u03b2-glucan is considered a fungal biomarker and exposure to this agent can induce lung inflammation. Complement activation plays an important role in early immune responses to \u03b2-glucan. Previous studies showed that T-regulatory cells (Tregs) regulated 1,3-\u03b2-glucan-induced lung inflammation by modulating the maintenance of immune homeostasis in the lung. Both interleukin (IL)-17 and TH17 cells play pivotal roles in inflammation associated with lung disease and share reciprocal developmental pathways with Tregs. However, the effect of Tregs on IL-17 and TH17 responses in 1,3-\u03b2-glucan- induced lung inflammation remains unclear. In this study, mice were exposed to 1,3-\u03b2-glucan by intratracheal instillation. To investigate the effects of Tregs on IL-17 and TH17 cells in the induced lung inflammation, a Treg-depleted mice model was generated by administration of anti-CD25 mAb. The results indicated that Treg-depleted mice showed more severe pathological inflammatory changes in lung tissues. Tregs depletion reduced IL-17 expression in these tissues, and increased those of TH1 cytokines. The expression of IL-17 increased at the early phase of the inflammation response. There were no significant effects of the Tregs on expression of ROR\u03b3t and IL-6 or the amount of CD4+IL-17+ cells in the lungs. When taken together, the late phase of the 1,3-\u03b2-glucan-induced inflammatory response in the mice was primarily mediated by TH1 cytokines rather than IL-17. In contrast, the early phase of the inflammatory response might be mediated in part by IL-17 along with activated complement. Tregs might be required for IL-17 expression during the late phase inflammatory response in mice. The increased IL-17 mRNA observed during the 1,3-\u03b2-glucan induced inflammatory response were attributed to cells other than TH17 cells. \u00a9 2013 Informa Healthcare USA, Inc.",
        "keywords": [
            "1",
            "3-\u03b2-glucan",
            "IL-17",
            "Lung inflammation",
            "Regulatory T-cells",
            "TH17"
        ],
        "authors": [
            {
                "name": "Ying Chen",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Fangwei Liu",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Dong Weng",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Laiyu Song",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Cuiying Li",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Wen Tang",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Ye Yu",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Wujing Dai",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Jie Chen",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            }
        ],
        "venue": "Journal of Immunotoxicology",
        "year": 2013
    },
    "9Sp4ceDZ": {
        "id": "9Sp4ceDZ",
        "title": "The dynamic changes of pneumoconiosis morbidity in a certain coal-mine",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "LIU Hong-bo",
                "org": ""
            },
            {
                "name": "YANG Yong-li",
                "org": ""
            },
            {
                "name": "TANG Zhi-feng",
                "org": ""
            },
            {
                "name": "WENG Dong",
                "org": ""
            },
            {
                "name": "SUN Gao",
                "org": ""
            },
            {
                "name": "CHEN Jie",
                "org": ""
            }
        ],
        "venue": "Chinese Journal of Industrial Medicine",
        "year": 2010
    },
    "69fBPex6": {
        "id": "69fBPex6",
        "title": "Sulforaphane prevents pulmonary damage in response to inhaled arsenic by activating the Nrf2-defense response.",
        "abstract": "Exposure to arsenic is associated with an increased risk of lung disease. Novel strategies are needed to reduce the adverse health effects associated with arsenic exposure in the lung. Nrf2, a transcription factor that mediates an adaptive cellular defense response, is effective in detoxifying environmental insults and prevents a broad spectrum of diseases induced by environmental exposure to harmful substances. In this report, we tested whether Nrf2 activation protects mice from arsenic-induced toxicity. We used an in vivo arsenic inhalation model that is highly relevant to low environmental human exposure to arsenic-containing dusts. Two-week exposure to arsenic-containing dust resulted in pathological alterations, oxidative DNA damage, and mild apoptotic cell death in the lung; all of which were blocked by sulforaphane (SF) in an Nrf2-dependent manner. Mechanistically, SF-mediated activation of Nrf2 alleviated inflammatory responses by modulating cytokine production. This study provides strong evidence that dietary intervention targeting Nrf2 activation is a feasible approach to reduce adverse health effects associated with arsenic exposure.",
        "keywords": [
            "antioxidant response",
            "arsenic",
            "keap1",
            "nrf2",
            "rna",
            "dna damage",
            "immunohistochemistry"
        ],
        "authors": [
            {
                "name": "Yi Zheng",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Shasha Tao",
                "org": "University of Arizona(University of Arizona),Tucson,United States"
            },
            {
                "name": "Fangru Lian",
                "org": "University of Arizona(University of Arizona),Tucson,United States"
            },
            {
                "name": "Binh T Chau",
                "org": "University of Arizona(University of Arizona),Tucson,United States"
            },
            {
                "name": "Jie Chen",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Guifan Sun",
                "org": "China Medical University Shenyang(China Medical University),Shenyang,China"
            },
            {
                "name": "Deyu Fang",
                "org": "Northwestern University Feinberg School of Medicine(Northwestern University Medical School,Northwestern University),Chicago,United States"
            },
            {
                "name": "R Clark Lantz",
                "org": "University of Arizona(University of Arizona),Tucson,United States"
            },
            {
                "name": "Donna D Zhang",
                "org": "University of Arizona(University of Arizona),Tucson,United States"
            }
        ],
        "venue": "Toxicology and applied pharmacology",
        "year": 2012
    },
    "qjgPmIZY": {
        "id": "qjgPmIZY",
        "title": "Maternal Marginal Iodine Deficiency Delays Cerebellar Bergmann Glial Cell Development in Rat Offspring: Involvement of Notch Signaling Pathway.",
        "abstract": "During early pregnancy, iodine deficiency (ID) is linked to adverse effects on child motor and psychomotor function. Maternal marginal ID has become a common public health problem. It is unclear whether marginal ID influences the development of the cerebellum or its underlying mechanisms. Thus, the purpose of this study was to determine the effects of marginal ID on the development of cerebellar Bergmann glial cells (BGs) and investigate the activation of the Notch signaling pathway, which is crucial for the development and morphology of BGs. We treated Wistar rats with an ID diet (iodine content 60\u202f\u00b1\u202f1.5\u202fng/g) supplemented with deionized water containing different concentrations of potassium iodide (KI) (183, 117, and 0\u202f\u03bcg/L for the control, marginal ID, and severe ID groups, respectively) during pregnancy and lactation. We explored the morphology of the BGs by Golgi-Cox staining and immunofluorescence and investigated the Notch signaling pathway using western blot. Our results showed that the marginal ID and severe ID groups had decreased cerebellar BG fiber lengths (P\u202f<\u202f 0.05 and 0.01, respectively) and numbers (P\u202f<\u202f 0.01 for both) on postnatal day (PN) 7, PN14, and PN21 compared to the control group. Moreover, the data showed that severe ID significantly reduced Dll1, Notch1, RBP-J\u03ba, and BLBP protein levels at all three time points. Marginal ID slightly reduced the expression of Notch1 on PN7 (P\u202f<\u202f 0.05) and PN21 (P\u202f<\u202f 0.01), RBP-J\u03ba on PN14 (P\u202f<\u202f 0.01) and PN21 (P\u202f<\u202f 0.05), and BLBP on PN7 (P\u202f<\u202f 0.05). There was no significant difference in Dll1 protein levels between the marginal ID and control groups at any time point. Our study suggests that marginal ID leads to mild damage to BG morphogenesis in the cerebellum. The abnormal regulation of the Notch signaling pathway may be involved in the damage to BGs.",
        "keywords": [
            "Bergmann glial cells",
            "Notch signaling pathway",
            "cerebellum",
            "marginal iodine deficiency"
        ],
        "authors": [
            {
                "name": "Ye Yu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Yuan Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Yi Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Jing Dong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Hui Min",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China. Electronic address: jchen@cmu.edu.cn."
            }
        ],
        "venue": "Neurotoxicology",
        "year": 2018
    },
    "AEZ6nw1i": {
        "id": "AEZ6nw1i",
        "title": "Effects of perinatal di (2-ethylhexyl) phthalate exposure on thyroid function in rat offspring.",
        "abstract": "Di (2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer in industry and displays the characteristics of an endocrine disruptor. Disorders of the maternal thyroid hormone (TH) during pregnancy can cause adverse effects on the fetus. We investigated the effects and possible mechanism of perinatal DEHP exposure on the thyroid function of pups. Pregnant female Wistar rats were randomly divided into four groups and received doses of DEHP of 0, 30, 300, 750\u2009mg/kg/day by gavage at from gestational day (GD) 0 to postnatal day (PN) 21. The concentration of serum THs and the ultrastructure of thyroid follicular cells in the offspring were examined. Related protein level and gene expression of thyroid proteins in pups were analyzed by western blotting and real-time PCR. We found that DEHP significantly reduced total thyroxine (TT) and increased thyroid stimulating hormone (TSH) in pups, while total triiodothyronine (TT) showed no change. Thyroid follicular cells ultrastructure was damaged in DEHP exposed pups as viewed by electron microscopy. Furthermore, exposure to DEHP significantly increased protein and mRNA levels of thyroid transcription factor 1 (TTF-1), paired box 8 (PAX8), sodium iodide symporter (NIS) and thyroid peroxidase (TPO) in pups. In addition, levels of deiodinases of pups were also affected. These findings indicated that DEHP can disrupt thyroid function by damaging thyroid follicles and affecting TTF-1, PAX8, NIS, TPO and the deiodinase protein family.",
        "keywords": [
            "DEHP",
            "Endocrine disruptors",
            "Offspring",
            "Perinatal period",
            "Thyroid function"
        ],
        "authors": [
            {
                "name": "Jing Dong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, People's Republic of China."
            },
            {
                "name": "Zhangzhao Cong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, People's Republic of China."
            },
            {
                "name": "Mingdan You",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, People's Republic of China."
            },
            {
                "name": "Yuanyuan Fu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, People's Republic of China."
            },
            {
                "name": "Yi Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, People's Republic of China."
            },
            {
                "name": "Yuan Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, People's Republic of China."
            },
            {
                "name": "Hui Fu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, People's Republic of China."
            },
            {
                "name": "Lingling Wei",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, People's Republic of China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang 110122, People's Republic of China. Electronic address: jchen@cmu.edu.cn."
            }
        ],
        "venue": "Environmental toxicology and pharmacology",
        "year": 2019
    },
    "WZEYgq5Y": {
        "id": "WZEYgq5Y",
        "title": "Developmental Hypothyroxinemia and Hypothyroidism Reduce Parallel Fiber-Purkinje Cell Synapses in Rat Offspring by Downregulation of Neurexin1/Cbln1/GluD2 Tripartite Complex.",
        "abstract": "Iodine is a significant micronutrient. Iodine deficiency (ID)-induced hypothyroxinemia and hypothyroidism during developmental period can cause cerebellar dysfunction. However, mechanisms are still unclear. Therefore, the present research aims to study effects of developmental hypothyroxinemia caused by mild ID and hypothyroidism caused by severe ID or methimazole (MMZ) on parallel fiber-Purkinje cell (PF-PC) synapses in filial cerebellum. Maternal hypothyroxinemia and hypothyroidism models were established in Wistar rats using ID diet and deionized water supplemented with different concentrations of potassium iodide or MMZ water. Birth weight and cerebellum weight were measured. We also examined PF-PC synapses using immunofluorescence, and western blot analysis was conducted to investigate the activity of Neurexin1/cerebellin1 (Cbln1)/glutamate receptor d2 (GluD2) tripartite complex. Our results showed that hypothyroxinemia and hypothyroidism decreased birth weight and cerebellum weight and reduced the PF-PC synapses on postnatal day (PN) 14 and PN21. Accordingly, the mean intensity of vesicular glutamate transporter (VGluT1) and Calbindin immunofluorescence was reduced in mild ID, severe ID, and MMZ groups. Moreover, maternal hypothyroxinemia and hypothyroidism reduced expression of Neurexin1/Cbln1/GluD2 tripartite complex. Our study supports the hypothesis that developmental hypothyroxinemia and hypothyroidism reduce PF-PC synapses, which may be attributed to the downregulation of Neurexin1/Cbln1/GluD2 tripartite complex. ",
        "keywords": [
            "Cerebellum",
            "Hypothyroidism",
            "Hypothyroxinemia",
            "Iodine deficiency",
            "Neurexin1/Cbln1/GluD2 tripartite complex",
            "Parallel fiber\u2013Purkinje cell synapses"
        ],
        "authors": [
            {
                "name": "Yuan Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, People's Republic of China."
            },
            {
                "name": "Jing Dong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, People's Republic of China."
            },
            {
                "name": "Yi Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, People's Republic of China."
            },
            {
                "name": "Wei Wei",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, People's Republic of China."
            },
            {
                "name": "Binbin Song",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, People's Republic of China."
            },
            {
                "name": "Zhongyan Shan",
                "org": "Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, People's Republic of China."
            },
            {
                "name": "Weiping Teng",
                "org": "Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Hospital of China Medical University, Shenyang, People's Republic of China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, People's Republic of China. chenjie@mail.cmu.edu.cn."
            }
        ],
        "venue": "Biological trace element research",
        "year": 2016
    },
    "4jpP8zgI": {
        "id": "4jpP8zgI",
        "title": "Effects of Maternal Marginal Iodine Deficiency on Interactions between Cerebellar Bergmann Glia Cells and Purkinje Cells in Rat Offspring.",
        "abstract": "Iodine deficiency (ID) during early pregnancy has an adverse effect on children's psychomotor and motor function but the mechanism has not been clarified. Therefore, our aim was to study the effect of maternal marginal ID on cerebellar neurodevelopment and the underlying mechanism. After obtaining marginal ID rats, we examined interactions between Bergmann glia cells (BGs) and Purkinje cells (PCs) using immunofluorescence and expression of the glutamate transporter and receptor by western blot. Our results showed that marginal ID reduced the number of contacted points between BGs and PCs, and disturbed expression of the glutamate transporter and receptor. Our results support the hypothesis that marginal ID inhibits interactions of BGs-PCs, which may be involved in abnormal regulation of the glutamate transporter and receptor.",
        "keywords": "",
        "authors": [
            {
                "name": "Ye Yu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110112, Liaoning, China."
            },
            {
                "name": "Jing Dong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110112, Liaoning, China."
            },
            {
                "name": "Yuan Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110112, Liaoning, China."
            },
            {
                "name": "Yi Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110112, Liaoning, China."
            },
            {
                "name": "Hui Min",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110112, Liaoning, China."
            },
            {
                "name": "Zhong Yan Shan",
                "org": "Department of Endocrinology and Metabolism, Liaoning Provincial Key Laboratory of Endocrine Diseases, the First Hospital of China Medical University, Shenyang 110001, Liaoning, China."
            },
            {
                "name": "Wei Ping Teng",
                "org": "Department of Endocrinology and Metabolism, Liaoning Provincial Key Laboratory of Endocrine Diseases, the First Hospital of China Medical University, Shenyang 110001, Liaoning, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110112, Liaoning, China."
            }
        ],
        "venue": "Biomedical and environmental sciences : BES",
        "year": 2017
    },
    "lKfsLfBg": {
        "id": "lKfsLfBg",
        "title": "A TSP-1 functional fragment inhibits activation of latent transforming growth factor-\u03b21 derived from rat alveolar macrophage after bleomycin treatment",
        "abstract": "The antineoplastic antibiotic, bleomycin, is known to induce a well-recognized model of lung fibrosis. Active transforming growth factor-\u03b21 (TGF-\u03b21) plays a key role in lung fibrosis induced by bleomycin, TSP-1 (thrombospondin-1) being critical to the activation of L (latent)-TGF-\u03b21 by virtue of an association of the TSP-1/L-TGF-\u03b21 complex with CD36, involving the sequence CSVTCG of the TSP-1 functional fragment. To observe the inhibitory effects of TSP-1 functional fragments, critical for CD36 binding, on the activation of L-TGF-\u03b21, we isolated alveolar macrophages from Wistar rat lungs 7 days after bleomycin administration (5 mg/kg body weight) and cultured the cells with or without TSP-1 functional or control fragments. We observed a cell surface association of TGF-\u03b21 with CD36 by immunofluorescence and quantified the active and total TGF-\u03b21 by ELISA. The co-localization of CD36 with TGF-\u03b21, shown by a yellow fluorescence deriving from a mixture of the green and red of the two components, for the TSP-1 functional fragment groups was clearly less than that of the TSP-1 control fragment groups. The quantities and the percentages of active TGF-\u03b21 in the TSP-1 functional fragment groups were lower than those in the TSP-1 control fragment groups (P<0.05 or P<0.01). These findings suggest that TSP-1 functional fragments could inhibit the activation of L-TGF-\u03b21 secreted by activated alveolar macrophages through blocking the binding of TSP-1 to CD36. \u00a9 2008 Elsevier GmbH. All rights reserved.",
        "keywords": [
            "Activation",
            "Alveolar macrophage",
            "Bleomycin-induced lung injury",
            "Latent transforming growth factor-\u03b21",
            "Thrombospondin-1"
        ],
        "authors": [
            {
                "name": "Ying Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 92 North 2nd Road, Heping District, Shenyang, Liaoning 110001, PR China"
            },
            {
                "name": "Xin Wang",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 92 North 2nd Road, Heping District, Shenyang, Liaoning 110001, PR China"
            },
            {
                "name": "Dong Weng",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 92 North 2nd Road, Heping District, Shenyang, Liaoning 110001, PR China"
            },
            {
                "name": "Shasha Tao",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 92 North 2nd Road, Heping District, Shenyang, Liaoning 110001, PR China"
            },
            {
                "name": "Lina Lv",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, 92 North 2nd Road, Heping District, Shenyang, Liaoning 110001, PR China"
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Experimental and toxicologic pathology : official journal of the Gesellschaft f\u00fcr Toxikologische Pathologie",
        "year": 2009
    },
    "YIvzcJfD": {
        "id": "YIvzcJfD",
        "title": "Prediction of the Incidence of Pneumoconiosis in Coal Mines",
        "abstract": "Objective To explore the incidence trend of pneumoconiosis in coal miners.Methods The study was performed using longitudinal retrospective data in Tiefa Colliery in China.The average person-year incidence rate,the age distribution of healthy coal miners and life expectancy of inhabitant of this region were used to estimate the number of the new potential pneumoconiosis patients in future.Results The study included 15918 coal miners without pneumoconiosis and 236 with pneumoconiosis.The number of new pneumoconiosis patients predicted in future was approximately 77.New pneumoconiosis patients predicted would mainly occur among those tunneling workers,approximately 66 workers.Most of them would be diagnosed in the period of next 20 years from 2008 to 2028.Conclusions New pneumoconiosis patients would occur among coal miners in Tiefa Colliery in China.However,there is a yearly decline as time goes by.",
        "keywords": [
            "Prediction",
            "Coal mine",
            "Pneumoconiosis"
        ],
        "authors": [
            {
                "name": "LIU Hong-bo",
                "org": "* School of Public Health,China Medical University,Shenyang  China"
            },
            {
                "name": "YANG Yong-li",
                "org": "* School of Public Health,China Medical University,Shenyang  China"
            },
            {
                "name": "WENG Dong",
                "org": "* School of Public Health,China Medical University,Shenyang  China"
            },
            {
                "name": "SUN Gao",
                "org": "* School of Public Health,China Medical University,Shenyang  China"
            },
            {
                "name": "CHEN Jie",
                "org": "* School of Public Health,China Medical University,Shenyang  China"
            }
        ],
        "venue": "Industrial Health and Occupational Diseases",
        "year": 2010
    },
    "rnevsIju": {
        "id": "rnevsIju",
        "title": "Perinatal Exposure to Nonylphenol Induces Microglia-Mediated Nitric oxide and Prostaglandin E2 Production in Offspring Hippocampus.",
        "abstract": "Nonylphenol (NP) is a persistent organic pollutant (POP) that has potential for neurotoxicity. The central nervous system (CNS) of fetus and child is highly sensitive to POPs, with environmental NP exposure, in particular, receiving increasing attention. Microglia (MG) are vital resident immune cells in CNS that defend against exogenous chemicals. This makes them a potentially target of NP. We sought to explore the effects of maternal exposure to NP during pregnancy and lactation on MG in the offspring hippocampus, the production of nitric oxide (NO) and prostaglandin E2 (PGE2) by MG, and the associated underlying mechanisms. We found that maternal exposure to NP activated MG and increased the production of NO and PGE2 in the offspring hippocampus. Nuclear translocation of p65 was found to co-localize with hippocampal MG. Activation of TLR4/MyD88/NF-\u03baB and Nrf2 signaling were observed in the offspring hippocampus. Interestingly, the inhibition of TLR4 signaling with CLI-095 partly inhibited NP-induced NO and PGE2 expression in BV2, a MG cell line. Together, our results suggested that maternal exposure to NP might increase the production of NO and PGE2 by over-activated MG in the offspring hippocampus. TLR4/MyD88/NF-\u03baB and Nrf2 signaling pathways may be involved in the activation of MG and the increased production of NO and PGE2.",
        "keywords": [
            "NF-\u03baB signaling",
            "Nrf2 signaling",
            "microglia",
            "nitric oxide",
            "nonylphenol",
            "prostaglandin E2"
        ],
        "authors": [
            {
                "name": "Zhenmin Qiu",
                "org": "Department of Occupational and Environmental Health, School of Public Heath, China Medical University, PR China."
            },
            {
                "name": "Yi Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Heath, China Medical University, PR China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Heath, China Medical University, PR China. Electronic address: Jchen@cmu.edu.cn."
            }
        ],
        "venue": "Toxicology letters",
        "year": 2018
    },
    "m6mvYQZW": {
        "id": "m6mvYQZW",
        "title": "4-1BB Signaling Promotes Alveolar Macrophages-Mediated Pro-Fibrotic Responses and Crystalline Silica-Induced Pulmonary Fibrosis in Mice.",
        "abstract": "Silicosis is caused by exposure to crystalline silica (CS). We have previously shown that blocking 4-1BB signaling attenuated CS-induced inflammation and pulmonary fibrosis. However, the cells that express 4-1BB, which plays a vital role in promoting fibrosis, are still unknown. In this study, we demonstrated that the expression of 4-1BB is elevated in alveolar macrophages (AMs) in the lungs of CS-injured mice. CS exposure also markedly enhanced the expression of 4-1BB in macrophage-like, MH-S cells. In these cells, activation of the 4-1BB signaling with an agonist antibody led to upregulated secretion of pro-fibrotic mediators. Consistently, blocking 4-1BB downstream signaling or genetic deletion of 4-1BB alleviated pro-fibrotic responses , while treatment with a 4-1BB fusion protein promoted pro-fibrotic responses.  experiments showed that blocking 4-1BB signaling decreased the expressions of pro-fibrotic mediators and fibrosis. These data suggest that 4-1BB signaling plays an important role in promoting AMs-mediated pro-fibrotic responses and pulmonary fibrosis. Our findings may provide a potential molecular target to reduce CS-induced fibrotic responses in occupational lung disease.",
        "keywords": [
            "4-1BB",
            "alveolar macrophages",
            "crystalline silica",
            "pro-fibrotic response",
            "pulmonary fibrosis"
        ],
        "authors": [
            {
                "name": "Yiping Lu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Chao Li",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Sitong Du",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Xi Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Xinning Zeng",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Fangwei Liu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Ying Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Jie Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China."
            }
        ],
        "venue": "Frontiers in immunology",
        "year": 2018
    },
    "nPdqDArc": {
        "id": "nPdqDArc",
        "title": "Effect of Iodine Deficiency and Hypothyroidism on Calmodulin Expression in Entorhinal Cortex of Rat Pups",
        "abstract": "Objective To observe the effect of iodine deficiency and hypothyroidism on calmodulin(CaM)expression in entorhinal cortex of rat pups.Methods A total of 28 pregnant Wistar rats were randomly divided into control group(n=7),hypothyroidism group(n=14),and iodine deficiency group(n=7).The rats of hypothyroidism group were subdivided into 5 ppm propylthiouracil(PTU)group(receiving 5 ppm of PTU,n=7)and 15 ppm PTU group(receiving 15 ppm of PTU,n=7),respectively.Five rat pups from each group were killed on postnatal day(PN)7,PN14,PN21,PN28,and PN42.Brain was sampled,and the exression of CaM in entorhinal cortex was detected by immunohistochemistry.Results On PN14,PN21,PN28,and PN42,the expression level of CaM in entorhinal cortex was significantly lower in iodine deficiency and 15 ppm PTU groups than in control group(P<0.05).No significant difference in the expression of CaM was found between any 2 of these 4 groups on PN7.Conclusion Iodine deficiency and hypothyroidism may decrease the expression of CaM in entorhinal cortex of rat pups.",
        "keywords": [
            "hypothyroidism",
            "entorhinal cortex",
            "iodine deficiency",
            "calmodulin",
            "genes",
            "immunohistochemistry",
            "trace elements",
            "iodine",
            "gene expression",
            "thyroid gland"
        ],
        "authors": [
            {
                "name": "HOU Yi",
                "org": "Department of Occupational and Environmental Health,School of Public Health,China Medical University,Shenyang ,China"
            },
            {
                "name": "WEI Wei",
                "org": "Department of Occupational and Environmental Health,School of Public Health,China Medical University,Shenyang ,China"
            },
            {
                "name": "DONG Jing",
                "org": "Department of Occupational and Environmental Health,School of Public Health,China Medical University,Shenyang ,China"
            },
            {
                "name": "WANG Yi",
                "org": "Department of Occupational and Environmental Health,School of Public Health,China Medical University,Shenyang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Department of Occupational and Environmental Health,School of Public Health,China Medical University,Shenyang ,China"
            }
        ],
        "venue": "Journal of China Medical University",
        "year": 2009
    },
    "rxB5G9Ru": {
        "id": "rxB5G9Ru",
        "title": "Prediction on the morbidity tendency of coal worker's pneumoconiosis in a certain coal mine",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "TIAN Lu-jia",
                "org": ""
            },
            {
                "name": "LIU Hong-bo",
                "org": ""
            },
            {
                "name": "YANG Yong-li",
                "org": ""
            },
            {
                "name": "TANG Zhi-feng",
                "org": ""
            },
            {
                "name": "WENG Dong",
                "org": ""
            },
            {
                "name": "CHEN Jie",
                "org": ""
            }
        ],
        "venue": "Chinese Journal of Industrial Medicine",
        "year": 2009
    },
    "UzZ3vJSP": {
        "id": "UzZ3vJSP",
        "title": "Marginal Iodine Deficiency Affects Dendritic Spine Development by Disturbing the Function of Rac1 Signaling Pathway on Cytoskeleton",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "hui min",
                "org": "china medical university"
            },
            {
                "name": "jing dong",
                "org": "china medical university"
            },
            {
                "name": "yuan wang",
                "org": "china medical university"
            },
            {
                "name": "ye yu",
                "org": "china medical university"
            },
            {
                "name": "zhongyan shan",
                "org": "china medical university"
            },
            {
                "name": "qi xi",
                "org": "university of tennessee"
            },
            {
                "name": "weiping teng",
                "org": "china medical university"
            },
            {
                "name": "jie chen",
                "org": "china medical university"
            }
        ],
        "venue": "Molecular Neurobiology",
        "year": 2016
    },
    "8SvTw63X": {
        "id": "8SvTw63X",
        "title": "Developmental iodine deficiency and hypothyroidism impair neural development, upregulate caveolin-1, and downregulate synaptotagmin-1 in the rat cerebellum.",
        "abstract": "Adequate thyroid hormone is critical for cerebellar development. Developmental hypothyroidism induced by iodine deficiency during gestation and postnatal period results in permanent impairments of cerebellar development with an unclear mechanism. In the present study, we implicate cerebellar caveolin-1 and synaptotagmin-1, the two important molecules involved in neuronal development, in developmental iodine deficiency, and in developmental hypothyroidism. Two developmental rat models were created by administrating dam rats with either iodine-deficient diet or propylthiouracil (PTU, 5 or 15 ppm)-added drinking water from gestational day 6 till postnatal day (PN) 28. Nissl staining and the levels of caveolin-1 and synaptotagmin-1 in cerebella were assessed on PN28 and PN42. The results show that the numbers of Purkinje cells were reduced in the iodine-deficient and PTU-treated rats. The upregulation of caveolin-1 and the downregulation of synaptotagmin-1 were observed in both iodine-deficient and PTU-treated rats. These findings may implicate decreases in the number of Purkinje cells and the alterations in the levels of caveolin-1 and synaptotagmin-1 in the impairments of cerebellar development induced by developmental iodine deficiency and hypothyroidism.",
        "keywords": [
            "iodine deficiency.cerebellum .nissl staining.caveolin-1.synaptotagmin-1",
            "Iodine deficiency",
            "Cerebellum",
            "Nissl staining",
            "Caveolin-1",
            "Synaptotagmin-1"
        ],
        "authors": [
            {
                "name": "Yi Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001 People\u2019s Republic of China"
            },
            {
                "name": "Jiapeng Zhong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001 People\u2019s Republic of China"
            },
            {
                "name": "Wei Wei",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001 People\u2019s Republic of China"
            },
            {
                "name": "Jian Gong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001 People\u2019s Republic of China"
            },
            {
                "name": "Jing Dong",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001 People\u2019s Republic of China"
            },
            {
                "name": "Fei Yu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001 People\u2019s Republic of China"
            },
            {
                "name": "Yuan Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001 People\u2019s Republic of China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001 People\u2019s Republic of China"
            }
        ],
        "venue": "Biological trace element research",
        "year": 2011
    },
    "XH04INMS": {
        "id": "XH04INMS",
        "title": "Effect of gamma-interferon on protein expressions of interleukin-4 and transforming growth factor-beta1 in experimental silicotic rats]",
        "abstract": "To study the effect of gamma-interferon on the protein expressions of interleukin-4 (IL-4) and transforming growth factor-beta(1)(TGF-beta1) on silicotic rats.Wistar rats were exposed to lower dose (20 mg) of quartz by intratracheal injection. Next day, the experimental rats were treated with gamma-interferon (1 x 10(5) IU) daily. Rats were killed in 1 month and 2 month to observe the changes of pathology of lung tissue by use of HE and VG staining, and the expressions of IL-4 and TGF-beta1 by use of immunohistochemical technique and quantitative analysis of protein expressions by image analysis system.(1) The fibrotic degree in silicotic lesions of rat lung was 1/2 approximately 1 grade less in IFN-gamma treated groups than in quartz controls. (2) Quantitative image analysis showed that the integrated optical density (IOD) of IL-4 positive cell in quartz controls in 1 month was (3.33 +/- 1.27) x 10(4) and decreased to (1.99 +/- 0.80) x 10(4) in 2 month, and that of TGF-beta1 positive cell increased from (3.67 +/- 0.63) x 10(4) to (4.90 +/- 1.11) x 10(4); The IOD of IL-4 positive cell in IFN-gamma treated groups was decreased from (2.19 +/- 0.90) x 10(4) to (0.61 +/- 0.22) x 10(4)(P < 0.05), and that of TGF-beta1 positive cell increased from (1.37 +/- 0.31) x 10(4) to (1.76 +/- 0.72) x 10(4) (P < 0.05). At these two time points, the IODof IL-4 and TGF-beta1 positive cell in IFN-gamma treated groups were lower than those in quartz controls (P < 0.05 or P < 0.01).gamma-interferon may inhibit the expressions of IL-4 and TGF-beta1 in silicotic rats.",
        "keywords": [],
        "authors": [
            {
                "name": "Ying Chen",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang 110001, China."
            },
            {
                "name": "Jing Dong",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases",
        "year": 2004
    },
    "QPvSmHvW": {
        "id": "QPvSmHvW",
        "title": "Tregs promote the differentiation of Th17 cells in silica-induced lung fibrosis in mice.",
        "abstract": "Silicosis is an occupational lung disease caused by inhalation of silica dust and characterized by lung inflammation and fibrosis. Previous study showed that Tregs regulate the process of silicosis by modulating the maintenance of immune homeostasis in the lung. Th17 cells share reciprocal developmental pathway with Tregs and play a pivotal role in the immunopathogenesis of many lung diseases by recruiting and activating neutrophils, but the regulatory function of Tregs on Th17 response in silica induced lung fibrosis remains to be explored.To evaluate the role of Th17 and IL-17 in the development of silicosis and their interaction with Tregs, Treg-depleted mice model was generated and exposed to silica to establish experimental model of silica-induced lung fibrosis. Here we showed that silica increased Th17 response in lung fibrosis. Tregs depletion enhanced the neutrophils accumulation and attenuated Th17 response in silica induced lung fibrosis. Both mRNA and protein results showed that Tregs exerted its modulatory function on Th17 cells and IL-17 by regulating TGF-\u03b21 and IL-1\u03b2.Our study suggested that Tregs could promote Th17 cells differentiation by regulating TGF-\u03b21 and IL-1\u03b2 in silica induced lung fibrosis of mice, which further the understanding of the progress of silicosis and provide a new insight in the regulatory mechanism of Th17 by Tregs in lung inflammation.",
        "keywords": [],
        "authors": [
            {
                "name": "Laiyu Song",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, People's Republic of China."
            },
            {
                "name": "Dong Weng",
                "org": ""
            },
            {
                "name": "Fangwei Liu",
                "org": ""
            },
            {
                "name": "Ying Chen",
                "org": ""
            },
            {
                "name": "Cuiying Li",
                "org": ""
            },
            {
                "name": "Lei Dong",
                "org": ""
            },
            {
                "name": "Wen Tang",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "PloS one",
        "year": 2012
    },
    "tZZ5qrJT": {
        "id": "tZZ5qrJT",
        "title": "Neurotoxicity of developmental hypothyroxinemia and hypothyroidism in rats: Impairments of long-term potentiation are mediated by phosphatidylinositol 3-kinase signaling pathway.",
        "abstract": "Neurotoxicity of iodine deficiency-induced hypothyroidism during developmental period results in serious impairments of brain function, such as learning and memory. These impairments are largely irreversible, and the underlying mechanisms remain unclear. In addition to hypothyroidism, iodine deficiency may cause hypothyroxinemia, a relatively subtle form of thyroid hormone deficiency. Neurotoxicity of developmental hypothyroxinemia also potentially impairs learning and memory. However, more direct evidence of the associations between developmental hypothyroxinemia and impairments of learning and memory should be provided, and the underlying mechanisms remain to be elucidated. Thus, in the present study, we investigated the effects of developmental hypothyroxinemia and hypothyroidism on long-term potentiation (LTP), a widely accepted cellular model of learning and memory, in the hippocampal CA1 region. The activation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway - a pathway closely associated with synaptic plasticity and learning and memory - was also investigated. Wistar rats were treated with iodine deficient diet or methimazole (MMZ) to induce developmental hypothyroxinemia or hypothyroidism. The results showed that developmental hypothyroxinemia caused by mild iodine deficiency and developmental hypothyroidism caused by severe iodine deficiency or MMZ significantly reduced the field-excitatory postsynaptic potential (f-EPSP) slope and the population spike (PS) amplitude. Decreased activation of the PI3K signaling pathway was also observed in rats subjected to developmental hypothyroxinemia or hypothyroidism. Our results may support the hypothesis that neurotoxicity of both developmental hypothyroxinemia and hypothyroidism causes damages to learning and memory. Our results also suggest that decreased activation of the PI3K signaling pathway may contribute to impairments of LTP caused by neurotoxicity of both developmental hypothyroxinemia and hypothyroidism.",
        "keywords": [
            "akt",
            "cns",
            "fp",
            "ft(3)",
            "ft(4)",
            "gd",
            "hfs",
            "hypothyroidism",
            "hypothyroxinemia",
            "id",
            "iodine deficiency",
            "ltp",
            "long-term potentiation",
            "mmz",
            "mammalian target of rapamycin",
            "pi3k",
            "pi3k signaling pathway",
            "pn",
            "ps",
            "th",
            "tsh",
            "central nervous system",
            "f-epsp",
            "field potential",
            "field-excitatory postsynaptic potential",
            "free thyroxine",
            "free triiodothyronine",
            "gestational day",
            "high-frequency stimulation",
            "mtor",
            "methimazole",
            "phosphatidylinositol 3-kinase",
            "population spike",
            "postnatal day",
            "serine/threonine protein kinase akt",
            "thyroid hormones",
            "thyroid stimulating hormone"
        ],
        "authors": [
            {
                "name": "Yi Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, PR China."
            },
            {
                "name": "Wei Wei",
                "org": ""
            },
            {
                "name": "Yuan Wang",
                "org": ""
            },
            {
                "name": "Jing Dong",
                "org": ""
            },
            {
                "name": "Binbin Song",
                "org": ""
            },
            {
                "name": "Hui Min",
                "org": ""
            },
            {
                "name": "Weiping Teng",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Toxicology and applied pharmacology",
        "year": 2013
    },
    "PQkhgtyU": {
        "id": "PQkhgtyU",
        "title": "Developmental hypothyroxinemia caused by mild iodine deficiency leads to HFS-induced LTD in rat hippocampal CA1 region: involvement of AMPA receptor.",
        "abstract": "Hypothyroidism induced by severe iodine deficiency (ID) during developmental period seriously damages the central nervous system function. In addition to developmental hypothyroidism induced by severe ID, developmental hypothyroxinemia induced by mild ID is potentially damaging for neurodevelopment and learning and memory in children. Wistar rats were treated with iodine-deficient diet or methimazole (MMZ) during pregnancy and lactation to induce developmental hypothyroxinemia or hypothyroidism in the present study. Pups were weaned on postnatal day (PN) 21 and used for electrophysiological recordings on PN80. It is generally accepted that long-term depression (LTD) is induced at low-frequency stimulation (LFS) in hippocampal CA1 region. Surprisingly, we observed developmental hypothyroxinemia as well as developmental hypothyroidism led to high-frequency stimulation (HFS)-induced LTD in hippocampal CA1 region. The abnormal HFS-induced LTD suggests not only developmental hypothyroidism but also developmental hypothyroxinemia impairs learning and memory. To explore the mechanisms responsible for the HFS-induced LTD, the phosphorylation status of \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) was investigated. The results showed that developmental hypothyroxinemia as well as developmental hypothyroidism decreased the phosphorylation of AMPAR subunit glutamate receptor 1 (GluR1) at serine 831 and serine 845 in hippocampal CA1 region. Neither developmental hypothyroxinemia nor developmental hypothyroidism altered the phosphorylation of AMPAR subunit glutamate receptor 2 (GluR2) at serine 880. Increased levels of protein phosphatase-1 (PP1) were also observed in hippocampal CA1 regions of pups subjected to developmental hypothyroxinemia or hypothyroidism. Taken together, our results suggest that the increased levels of PP1 caused by developmental hypothyroxinemia or hypothyroidism may account for the dephosphorylation of GluR1 at serine 831 and serine 845, which may contribute to HFS-induced LTD in hippocampal CA1 region.",
        "keywords": [
            "Hypothyroxinemia",
            "Hypothyroidism",
            "Iodine deficiency",
            "Long-term depression",
            "AMPARs",
            "Protein phosphatase-1"
        ],
        "authors": [
            {
                "name": "Yi Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001, People's Republic of China."
            },
            {
                "name": "Wei Wei",
                "org": ""
            },
            {
                "name": "Binbin Song",
                "org": ""
            },
            {
                "name": "Yuan Wang",
                "org": ""
            },
            {
                "name": "Jing Dong",
                "org": ""
            },
            {
                "name": "Hui Min",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Molecular neurobiology",
        "year": 2014
    },
    "prIX5ykA": {
        "id": "prIX5ykA",
        "title": "Hypothyroxinemia induced by maternal mild iodine deficiency impairs hippocampal myelinated growth in lactational rats.",
        "abstract": "Hypothyroxinemia induced by maternal mild iodine deficiency causes neurological deficits and impairments of brain function in offspring. Hypothyroxinemia is prevalent in developing and developed countries alike. However, the mechanism underlying these deficits remains less well known. Given that the myelin plays an important role in learning and memory function, we hypothesize that hippocampal myelinated growth may be impaired in rat offspring exposed to hypothyroxinemia induced by maternal mild iodine deficiency. To test this hypothesis, the female Wistar rats were used and four experimental groups were prepared: (1) control; (2) maternal mild iodine deficiency diet inducing hypothyroxinemia; (3) hypothyroidism induced by maternal severe iodine deficiency diet; (4) hypothyroidism induced by maternal methimazole water. The rats were fed the diet from 3 months before pregnancy to the end of lactation. Our results showed that the physiological changes occuring in the hippocampal myelin were altered in the mild iodine deficiency group as indicated by the results of immunofluorescence of myelin basic proteins on postnatal day 14 and postnatal day 21. Moreover, hypothyroxinemia reduced the expressions of oligodendrocyte lineage transcription factor 2 and myelin-related proteins in the treatments on postnatal day 14 and postnatal day 21. Our data suggested that hypothyroxinemia induced by maternal mild iodine deficiency may impair myelinated growth of the offspring. \u00a9 2014 Wiley Periodicals, Inc. Environ Toxicol, 2014.",
        "keywords": [
            "hippocampus",
            "hypothyroxinemia",
            "iodine deficiency",
            "myelinated growth"
        ],
        "authors": [
            {
                "name": "Wei Wei",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, People's Republic of China; Department of Endocrinology and Metabolism and Liaoning Provincial Key Laboratory of Endocrine Diseases, the First Hospital of China Medical University, Shenyang, People's Republic of China."
            },
            {
                "name": "Yi Wang",
                "org": ""
            },
            {
                "name": "Jing Dong",
                "org": ""
            },
            {
                "name": "Yuan Wang",
                "org": ""
            },
            {
                "name": "Hui Min",
                "org": ""
            },
            {
                "name": "Binbin Song",
                "org": ""
            },
            {
                "name": "Zhongyan Shan",
                "org": ""
            },
            {
                "name": "Weiping Teng",
                "org": ""
            },
            {
                "name": "Qi Xi",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Environmental toxicology",
        "year": 2014
    },
    "Cq3ySUs7": {
        "id": "Cq3ySUs7",
        "title": "Study of the therapeutic effect of gamma-interferon on early experimental silicosis in rats]",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Ying Chen",
                "org": ""
            },
            {
                "name": "Wan-yang Liu",
                "org": ""
            },
            {
                "name": "Jing Dong",
                "org": ""
            },
            {
                "name": "Zhen-jie Liu",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases",
        "year": 2004
    },
    "YslZoiT7": {
        "id": "YslZoiT7",
        "title": "Developmental iodine deficiency delays the maturation of newborn granule neurons associated with downregulation of p35 in postnatal rat hippocampus.",
        "abstract": "We evaluated the role of p35 in the maturation of hippocampal granule neurons in offspring caused by developmental iodine deficiency. Two developmental rat models were established with either an iodine-deficient diet, or propylthiouracil-adulterated water (5 ppm) to impair thyroid function, in pregnant rats from gestational day 6 until postnatal day 28. The protein levels of p35, cyclin-dependent kinase 5, \u03b2-catenin, and N-cadherin were assessed on postnatal day 14, 21, and 28. Dendritic morphogenesis of newborn granule neurons in dentate gyrus was examined. Developmental hypothyroidism induced by iodine deficiency and PTU treatment delayed the maturation of hippocampal granule neurons in the offspring and decreased the percentage of Dcx-positive neurons that expressed \u03b2-catenin on postnatal day 21 and 28. In addition, downregulation of p35 was observed in dentate gyrus of hypothyroid groups. Developmental hypothyroidism induced by iodine deficiency and PTU treatment could delay the maturation of newborn granule neurons in dentate gyrus, and this deficit may be attributed to the downregulation of p35.",
        "keywords": [
            "dentate gyrus",
            "development",
            "granule cell",
            "iodine deficiency",
            "p35"
        ],
        "authors": [
            {
                "name": "Fei Yu",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001, People's Republic of China; Liaoning Provincial Key Laboratory of Endocrine Diseases, China Medical University, Shenyang, People's Republic of China; Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, Shenyang, People's Republic of China."
            },
            {
                "name": "Yi Wang",
                "org": ""
            },
            {
                "name": "Hongde Xu",
                "org": ""
            },
            {
                "name": "Jing Dong",
                "org": ""
            },
            {
                "name": "Wei Wei",
                "org": ""
            },
            {
                "name": "Yuan Wang",
                "org": ""
            },
            {
                "name": "Zhongyan Shan",
                "org": ""
            },
            {
                "name": "Weiping Teng",
                "org": ""
            },
            {
                "name": "Qi Xi",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Environmental toxicology",
        "year": 2014
    },
    "SwNZyQGF": {
        "id": "SwNZyQGF",
        "title": "Maternal Hypothyroxinemia-Induced Neurodevelopmental Impairments in the Progeny.",
        "abstract": "Maternal hypothyroxinemia can induce neurodevelopmental impairments in the developing fetus. We here review recent studies on the epidemiology and molecular mechanisms associated with this important public health issue. In 2011, the American Thyroid Association defined maternal hypothyroxinemia as low serum free thyroxine (FT4) levels (<5th or <10th percentile) existing in conjunction with normal serum free triiodothyronine (FT3) or thyroid stimulating hormone (TSH) levels during pregnancy. Compared to clinical or subclinical hypothyroidism, hypothyroxinemia is more commonly found in pregnant women. Hypothyroxinemia usually ensues in response to several factors, such as mild iodine deficiency, environmental endocrine disrupters, or certain thyroid diseases. Unequivocal evidence demonstrates that maternal hypothyroxinemia leads to negative effects on fetal brain development, increasing the risks for cognitive deficits and poor psychomotor development in resulting progeny. In support of this, rodent models provide direct evidence of neurodevelopmental damage induced by maternal hypothyroxinemia, including dendritic and axonal growth limitation, neural abnormal location, and synaptic function alteration. The neurodevelopmental impairments induced by hypothyroxinemia suggest an independent role of T4. Increasing evidence indicates that adequate thyroxine is required for the mothers in order to protect against the abnormal brain development in their progeny.",
        "keywords": [
            "Hypothyroxinemia",
            "Neurodevelopment",
            "Cognition",
            "Psychomotor development",
            "Pregnancy"
        ],
        "authors": [
            {
                "name": "Hui Min",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110013, People's Republic of China."
            },
            {
                "name": "Jing Dong",
                "org": ""
            },
            {
                "name": "Yi Wang",
                "org": ""
            },
            {
                "name": "Yuan Wang",
                "org": ""
            },
            {
                "name": "Weiping Teng",
                "org": ""
            },
            {
                "name": "Qi Xi",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Molecular neurobiology",
        "year": 2015
    },
    "50qGptMr": {
        "id": "50qGptMr",
        "title": "Th17 can regulate silica-induced lung inflammation through an IL-1\u03b2-dependent mechanism.",
        "abstract": "Silicosis is an occupational lung disease caused by the inhalation of silica dust and characterized by lung inflammation and fibrosis. Interleukin (IL)-1\u03b2 is induced by silica and functions as the key pro-inflammatory cytokine in this process. The Th17 response, which is induced by IL-1\u03b2, has been reported very important in chronic human lung inflammatory diseases. To elucidate the underlying mechanisms of IL-1\u03b2 and IL-17 in silicosis, we used anakinra and an anti-IL-17 monoclonal antibody (mAb) to block the receptor of IL-1\u03b2 (IL-RI) and IL-17, respectively, in a mouse model of silicosis. We observed increased IL-1\u03b2 expression and an enhanced Th17 response after silica instillation. Treatment with an IL-1 type I receptor (IL-1RI) antagonist anakinra substantially decreased silica-induced lung inflammation and the Th17 response. Lung inflammation and the accumulation of inflammatory cells were attenuated in the IL-17-neutralized silicosis group. IL-17 may promote lung inflammation by modulating the differentiation of Th1 and regulatory T cells (Tregs) and by regulating the production of IL-22 and IL-1\u03b2 during the lung inflammation of silicosis. Silica may induce IL-1\u03b2 production from alveolar macrophages and promote inflammation by initiating a Th17 response via an IL-1\u03b2/IL-1RI-dependent mechanism. The Th17 response could induce lung inflammation during the pathogenesis of silicosis by regulating the homoeostasis of the Th immune responses and affecting the production of IL-22 and IL-1\u03b2. This study describes a potentially important inflammatory mechanism of silicosis that may bring about novel therapies for this inflammatory and fibrotic disease.",
        "keywords": [
            "il-1\u03b2",
            "th17",
            "lung inflammation",
            "silicosis"
        ],
        "authors": [
            {
                "name": "Laiyu Song",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, China; Department of Clinical Immunology, Dalian Medical University, Dalian, China."
            },
            {
                "name": "Dong Weng",
                "org": ""
            },
            {
                "name": "Wujing Dai",
                "org": ""
            },
            {
                "name": "Wen Tang",
                "org": ""
            },
            {
                "name": "Shi Chen",
                "org": ""
            },
            {
                "name": "Chao Li",
                "org": ""
            },
            {
                "name": "Ying Chen",
                "org": ""
            },
            {
                "name": "Fangwei Liu",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Journal of cellular and molecular medicine",
        "year": 2014
    },
    "PLU2D7z0": {
        "id": "PLU2D7z0",
        "title": "Developmental hypothyroxinaemia and hypothyroidism limit dendritic growth of cerebellar Purkinje cells in rat offspring: involvement of microtubule-associated protein 2 (MAP2) and stathmin.",
        "abstract": "Iodine is essential for the synthesis of thyroid hormone. Iodine deficiency (ID)-induced hypothyroxinaemia and hypothyroidism during developmental period contribute to impairments of function in the brain, such as psychomotor and motor alterations. However, the mechanisms are still unclear. Therefore, the present research is to study the effects of developmental hypothyroxinaemia caused by mild ID and developmental hypothyroidism caused by severe ID or methimazole (MMZ) on dendritic growth in filial cerebellar Purkinje cells (PCs) and the underlying mechanisms.A maternal hypothyroxinaemia model was established in Wistar rats using a mild ID diet, and two maternal hypothyroidism models were developed with either severe ID diet or MMZ water. We examined the total dendritic length using immunofluorescence, and Western blot analysis was conducted to investigate the activity of microtubule-associated protein 2 (MAP2), stathmin and calcium/calmodulin-dependent protein kinase II (CaMKII).Hypothyroxinaemia and hypothyroidism reduced the total dendritic length of cerebellar PCs, decreased MAP2 and its phosphorylation, increased stathmin but reduced its phosphorylation and down-regulated the activity of CaMKII and its phosphorylation in cerebellar PCs on postnatal day (PN) 7, PN14 and PN21.Developmental hypothyroxinaemia induced by mild ID and hypothyroidism induced by severe ID or MMZ limit PCs dendritic growth, which may involve in the disturbance of MAP2 and stathmin in a CaMKII-dependent manner. It suggests a potential mechanism of motor coordination impairments caused by developmental hypothyroxinaemia and hypothyroidism.",
        "keywords": [
            "purkinje cells",
            "cerebellum",
            "dendrite",
            "hypothyroidism",
            "hypothyroxinaemia",
            "iodine deficiency"
        ],
        "authors": [
            {
                "name": "Yuan Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, China."
            },
            {
                "name": "Yi Wang",
                "org": ""
            },
            {
                "name": "Jing Dong",
                "org": ""
            },
            {
                "name": "Wei Wei",
                "org": ""
            },
            {
                "name": "Binbin Song",
                "org": ""
            },
            {
                "name": "Hui Min",
                "org": ""
            },
            {
                "name": "Weiping Teng",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Neuropathology and applied neurobiology",
        "year": 2014
    },
    "UEi2lfg7": {
        "id": "UEi2lfg7",
        "title": "CD4+CD25+Foxp3+ regulatory T cells depletion may attenuate the development of silica-induced lung fibrosis in mice.",
        "abstract": "Silicosis is an occupational lung disease caused by inhalation of silica dust characterized by lung inflammation and fibrosis. Previous study showed that Th1 and Th2 cytokines are involved in silicosis, but Th1/Th2 polarization during the development of silicosis is still a matter of debate. Regulatory T cells (Treg cells) represent a crucial role in modulation of immune homeostasis by regulating Th1/Th2 polarization, but their possible implication in silicosis remains to be explored.To evaluate the implication of Treg cells in the development of silicosis, we generated the Treg-depleted mice model by administration of anti-CD25 mAbs and mice were exposed to silica by intratracheal instillation to establish experimental model of silica-induced lung fibrosis. The pathologic examinations show that the Treg-depleted mice are susceptive to severer inflammation in the early stage, with enhanced infiltration of inflammatory cells. Also, depletion of Treg cells causes a delay of the progress of silica-induced lung fibrosis in mice model. Further study of mRNA expression of cytokines reveals that depletion of Tregs leads to the increased production of Th1-cytokines and decreased production of Th2-cytokine. The Flow Cytometry and realtime PCR study show that Treg cells exert the modulation function both directly by expressing CTLA-4 at the inflammatory stage, and indirectly by secreting increasing amount of IL-10 and TGF-\u03b2 during the fibrotic stage in silica-induced lung fibrosis.Our study suggests that depletion of Tregs may attenuate the progress of silica-induced lung fibrosis and enhance Th1 response and decelerate Th1/Th2 balance toward a Th2 phenotype in silica-induced lung fibrosis. The regulatory function of Treg cells may depend on direct mechanism and indirect mechanism during the inflammatory stage of silicosis.",
        "keywords": [
            "gene expression",
            "interleukin 4",
            "flow cytometry"
        ],
        "authors": [
            {
                "name": "Fangwei Liu",
                "org": "Division of Pneumoconiosis, School of Public Health, China Medical University, Shenyang, People's Republic of China."
            },
            {
                "name": "Jie Liu",
                "org": ""
            },
            {
                "name": "Dong Weng",
                "org": ""
            },
            {
                "name": "Ying Chen",
                "org": ""
            },
            {
                "name": "Laiyu Song",
                "org": ""
            },
            {
                "name": "Qincheng He",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "PloS one",
        "year": 2010
    },
    "7OLoGskl": {
        "id": "7OLoGskl",
        "title": "Developmental hypothyroxinemia and hypothyroidism reduce proliferation of cerebellar granule neuron precursors in rat offspring by downregulation of the sonic hedgehog signaling pathway.",
        "abstract": "Iodine deficiency (ID)-induced hypothyroxinemia and hypothyroidism during development result in dysfunction of the central nervous system, affecting psychomotor and motor function, although the underlying mechanisms causing these alterations are still unclear. Therefore, our aim is to study the effects of developmental hypothyroxinemia, caused by mild ID, and developmental hypothyroidism, caused by severe ID or methimazole (MMZ), on the proliferation of cerebellar granule neuron precursors (CGNPs), an excellent experimental model of cerebellar development and function. The sonic hedgehog (Shh) signaling pathway is essential for CGNP proliferation, and as such, its activation is also investigated here. A maternal hypothyroxinemia model was established in Wistar rats by administrating a mild ID diet, and two maternal hypothyroidism models were developed either by administrating a severe ID diet or MMZ water. Our results showed that hypothyroxinemia and hypothyroidism reduced proliferation of CGNPs on postnatal day (PN) 7, PN14, and PN21. Accordingly, the mean intensity of proliferating cell nuclear antigen and Ki67 nuclear antigen immunofluorescence was reduced in the mild ID, severe ID, and MMZ groups. Moreover, maternal hypothyroxinemia and hypothyroidism reduced expression of the Shh signaling pathway on PN7, PN14, and PN21. Our study supports the hypothesis that developmental hypothyroxinemia induced by mild ID, and hypothyroidism induced by severe ID or MMZ, reduce the proliferation of CGNPs, which may be ascribed to the downregulation of the Shh signaling pathway.",
        "keywords": [
            "Iodine deficiency",
            "Hypothyroxinemia",
            "Hypothyroidism",
            "Cerebellar granule neuron precursors",
            "Proliferation",
            "Shh signaling pathway"
        ],
        "authors": [
            {
                "name": "Yuan Wang",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang, 110001, People's Republic of China."
            },
            {
                "name": "Yi Wang",
                "org": ""
            },
            {
                "name": "Jing Dong",
                "org": ""
            },
            {
                "name": "Wei Wei",
                "org": ""
            },
            {
                "name": "Binbin Song",
                "org": ""
            },
            {
                "name": "Hui Min",
                "org": ""
            },
            {
                "name": "Ye Yu",
                "org": ""
            },
            {
                "name": "Xibing Lei",
                "org": ""
            },
            {
                "name": "Ming Zhao",
                "org": ""
            },
            {
                "name": "Weiping Teng",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Molecular neurobiology",
        "year": 2014
    },
    "OWONim6t": {
        "id": "OWONim6t",
        "title": "Hypothyroxinemia induced by mild iodine deficiency deregulats thyroid proteins during gestation and lactation in dams.",
        "abstract": "The main object of the present study was to explore the effect on thyroidal proteins following mild iodine deficiency (ID)-induced maternal hypothyroxinemia during pregnancy and lactation. In the present study, we established a maternal hypothyroxinemia model in female Wistar rats by using a mild ID diet. Maternal thyroid iodine content and thyroid weight were measured. Expressions of thyroid-associated proteins were analyzed. The results showed that the mild ID diet increased thyroid weight, decreased thyroid iodine content and increased expressions of thyroid transcription factor 1, paired box gene 8 and Na+/I- symporter on gestational day (GD) 19 and postpartum days (PN) 21 in the maternal thyroid. Moreover, the up-regulated expressions of type 1 iodothyronine deiodinase (DIO1) and type 2 iodothyronine deiodinase (DIO2) were detected in the mild ID group on GD19 and PN21. Taken together, our data indicates that during pregnancy and lactation, a maternal mild ID could induce hypothyroxinemia and increase the thyroidal DIO1 and DIO2 levels.",
        "keywords": [
            "gestation",
            "thyroid"
        ],
        "authors": [
            {
                "name": "Wei Wei",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, 92 North 2nd Road, Shenyang 110001, China. weiwei840403@163.com"
            },
            {
                "name": "Yi Wang",
                "org": ""
            },
            {
                "name": "Jing Dong",
                "org": ""
            },
            {
                "name": "Yuan Wang",
                "org": ""
            },
            {
                "name": "Hui Min",
                "org": ""
            },
            {
                "name": "Binbin Song",
                "org": ""
            },
            {
                "name": "Zhongyan Shan",
                "org": ""
            },
            {
                "name": "Weiping Teng",
                "org": ""
            },
            {
                "name": "Qi Xi",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "International journal of environmental research and public health",
        "year": 2013
    },
    "5uofv4mX": {
        "id": "5uofv4mX",
        "title": "Effect of iodine deficiency and hypothyroidism on the protein expressions of CaMK II in the hippocampus of pups]",
        "abstract": "To observe the effect of iodine deficiency and hypothyroidism on the protein expressions of CaMK II in the hippocampus of pups.Female Wistar rats (n=28) after pregnancy were randomly divided into control group, hypothyroid group and iodine deficient group. According to the dose of PTU in fed water, hypothyroid group was divided into 5 mg/L group and 15 mg/L group (7 in each). 5 pups from each group were sacrificed and perfused intracardially in PN7, PN14 and PN21. Brains were removed, fixed and sectioned coronally. All sections were observed and analyzed the protein exression of CaMK II by immunohistochemistry in the hippocampus CA1, CA3 and DG regions.Control group in CA1, CA3 and DG regions of the hippocampus had strong positive staining and the cytoplasm of neurons were filled with CaMK II. The distribution of the immune reaction product in hippocampus of 5 mg/L, 15 mg/L and iodine groups were in line with the control group, but the staining intensity as compared with the control group gradually decreased. In PN21 and PN14, integrated optical density average of CaMK II in CA1, CA3 and DG regions of the hippocampus in iodine deficient group [PN21: (26.05 +/- 4.98), (30.79 +/- 3.22), (26.40 +/- 2.63); PN14:(25.48 +/- 4.87), (44.17 +/- 5.91), (26.41 +/- 3.01)] and 15 mg/L groups [PN21: (17.02 +/- 2.68), (24.57 +/- 6.62), (20.18 +/- 4.05); PN14:(20.66 +/- 3.51), (34.94 +/- 5.09), (27.32 +/- 4.97)] were significantly lower than those of controls [PN21: (57.75 +/- 13.22), (65.03 +/- 6.20), (49.39 +/- 8.41), P < 0.05; PN14: (54.08 +/- 12.00), (71.04 +/- 5.07), (78.52 +/- 12.42), P < 0.05]. In PN7, integrated optical density average of CaMK II in CA1 region of the hippocampus in iodine deficient group (25.74 +/- 3.33) and 15 mg/L groups (26.89 +/- 5.25) were significantly lower than those of controls(40.53 +/- 3.65), P < 0.05.Iodine deficiency and hypothyroidism may decrease the protein expression of CaMK II.",
        "keywords": [],
        "authors": [
            {
                "name": "Wei Wei",
                "org": "Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110001, China. weiwei840403@163.com"
            },
            {
                "name": "Jing Dong",
                "org": ""
            },
            {
                "name": "Wanyang Liu",
                "org": ""
            },
            {
                "name": "Yi Wang",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Wei sheng yan jiu = Journal of hygiene research",
        "year": 2010
    },
    "RFJs3Zig": {
        "id": "RFJs3Zig",
        "title": "The clinical research of Atrium ProLoop Mesh Plug in treatment of inguinal hernia",
        "abstract": "Objective To investigate the indication and effect of Atrium ProLoop Mesh Plug( 3-dimensional pre-formed plug) in treatment of inguinal hernia. Methods To analyze the clinical data of 200patients with inguinal hernias in Beijing Chaoyang Hospital from February 2006 to February 2008,all patients received Atrium ProLoop Mesh Plug tension-free repair with local nerve blockade anesthesia. Data collected included: operation time,the time of out-of-bed activity,the condition of postoperative pain,days of postoperative stay,the cost of operation,the cases of postoperative complications and recurrence rate.Results The average operation time was 23 minutes,all patients could act out-of-bed after operation immediately and with little pain,no one had used paregoric,the average days of postoperative stay was 1. 5 days,there was no retention of urine,scrotum seroma or wound infection,the average cost of operation was 4678yuan( RMB). During the follow up period of 4-28 months,there was no recurrence,no postoperative chronic pain or foreign body sensation. Conclusions The method of tension-free herniorrhaphy with 3-dimensional pre-formed plug more fit to human anatomic structure,less interfere with inguinal region anatomic structure,and with less trauma. It is a simple,safe and effective surgical procedures,especially refer to inguinal indirect hernia or direct hernia with modicus defect of transversalic fascia.",
        "keywords": [
            "3-dimensional plug",
            "operative",
            "inguinal",
            "Hernia",
            "Surgical procedures",
            "Tension-free hernioplasty"
        ],
        "authors": [
            {
                "name": "LIU Su-jun",
                "org": ""
            },
            {
                "name": "CHEN Jie",
                "org": ""
            },
            {
                "name": "SHEN Ying-mo",
                "org": ""
            },
            {
                "name": "WANG Ming-gang",
                "org": ""
            },
            {
                "name": "BAO Shao-yu",
                "org": ""
            },
            {
                "name": "ZHU Yi-lin",
                "org": ""
            }
        ],
        "venue": "Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition)",
        "year": 2008
    },
    "qnv2EasO": {
        "id": "qnv2EasO",
        "title": "Approach of tension-free hernia repair for umbilical hernia under local nerve blockade anaesthesia with shanyu mesh in adults",
        "abstract": "Objective To discuss the value of tension-free hernia repair for umbilical hernia under local nerve blockade anaesthesia with Shanyu mesh in adults.Methods Analyze the cases of Twenty-five adult patients with umbilical hernia treated with tension-free hernia repair under local nerve blockade anaesthesia with Shanyu mesh,The anaesthetic effect,operative time,the average stay in hospital,complication and recurrence rate were studied.Results All operations were under local nerve blockade anaesthesia,the operative time was 35 to 85 minutes,average time was 55 minutes,the time of patients postopertavie recovery was 0 to 2 hours,the obvious postopertavie pain was 5 cases.,the postopertavie subcutaneous seroma was 1 case,the average stay in hospital were 3.5 days,The average follow-up period was 11 months and no recurrence was observed,no one had the feeling of foreign body.Conclusions The tension-free hernia repair for umbilical hernia under local nerve blockade anaesthesia with Shanyu mesh was a effective and credible operative method,and it has many advantages,such as safety,wide indication,rapid recovery,fewer complication and lower recurrence rate.",
        "keywords": [
            "anesthesia",
            "Local",
            "Hernia",
            "Artificial synthetic material",
            "Tension-free hernia repair",
            "umbilical"
        ],
        "authors": [
            {
                "name": "WANG Ming-gang",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital Affiliated The Capital Medical University,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital Affiliated The Capital Medical University,Beijing ,China"
            },
            {
                "name": "LIU Su-jun",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital Affiliated The Capital Medical University,Beijing ,China"
            },
            {
                "name": "SHEN Ying-mo",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital Affiliated The Capital Medical University,Beijing ,China"
            },
            {
                "name": "WANG Fan",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital Affiliated The Capital Medical University,Beijing ,China"
            },
            {
                "name": "ZHU Yi-lin",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital Affiliated The Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Hernia and Abdominal Wall Surgery",
        "year": 2008
    },
    "ZBGKUiFU": {
        "id": "ZBGKUiFU",
        "title": "Clinical research of two kinds of open operation in herniorrhaphy with artificial synthetic material for parastomal hernias",
        "abstract": "Objective To evaluate the effect of two kinds of open operation in herniorrhaphy with artificial synthetic material for parastomal hernias by the application with the method of IPOM or Onlay respectively.Methods The clinical data of 48 patients with parastomal hernia admitted from January 2002 to July 2007 at Beijing Chaoyang Hospital of Capital University of Medical Science were analyzed retrospectively.Twenty-five patients received Bard CK parastomal patch repair(IPOM group) .Twenty-three patients received Bard Marlex mesh repair(Onlay group) .Data collected included operation time,days of postoperative stay,the cases of postoperative complications.The data were analyzed by statistical method.Results No significant difference was found between the two groups in the operation time and the days of postoperative stay.During the follow up period of 6\uff5e72 months,there was no recurrence but there were 2 cases of wound infection,2 cases of subcutaneous seroma and 3 cases of postoperative chronic pain or foreign body sensation in the IPOM group.There were 5 cases of recurrence,4 cases of wound infection,6 cases of subcutaneous seroma and 9 cases of postoperative chronic pain or foreign body sensation in the Onlay group.The incidence of recurrence and postopera-tive chronic pain or foreign body sensation in the IPOM group were lower than those in the Onlay group significantly(P<0.05) .Conclusion The two kinds of open operation in herniorrhaphy with artificial synthetic material for parastomal hernias are safe and effective surgical procedures.The method of IPOM can diminish the incidence of recurrence and postoperative chronic pain or foreign body sensation,and diminish the incidence of postoperative wound infection and subcutaneous seroma.",
        "keywords": [
            "parastomal hernia",
            "herniorrhaphy",
            "artificial synthetic material"
        ],
        "authors": [
            {
                "name": "SHEN Ying-mo",
                "org": ".Center of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital University of Medical Science,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": ".Center of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital University of Medical Science,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Practical Surgery",
        "year": 2008
    },
    "OyffOK7i": {
        "id": "OyffOK7i",
        "title": "Preparation of monoclonal antibodies specific to M30 (Cytokeratin 18 apoptosis fragment) and its primary application in detection of liver injure of chronic hepatitis B",
        "abstract": "Objective To prepare monoclonal antibody( MAb) against M30( apoptosis fragment of Cytokeratin 18) and investigate its specificity of cell apoptosis detection.Methods BALB / C mice were immunized with M30-BSA( 13 amino acid residues peptide).Spleen cells of the mice with good reaction were fused with myeloma cells SP2 /0.Hybridomas were separated by culturing in HAT cultures.The stable monoclonal hubridomas were isolated by limiting dilution.Mouse ascites were prepared by intraperitoneal injection of hybridoma cells.After purified,the types and subclasses of monoclonal antibodies were identified by indirect ELISA.The specificity of these antibodies was detected by immunofluorescene staining.The ELISA plate was coated by the M30 antibody.The level of M30 antigen from serum of 35 chronic hepatitis B patients were investigated.Results Three strains of hybridoma cell lines which could secrete M30 MAb stably were obtained.The three antibodies were all IgG2a subclass and type \u03ba.The antibodies could specifically hybridize with apoptosis hepatocytes.M30 antigen in serum of chronic hepatitis B patients detected by M30 monoclonal antibody had good correlation with ALT and AST.Conclusion Antibodies against CK18 apoptosis fragment M30 were obtained.These antibodies had great specificity of cell apoptosis detection and might be used in liver injure detection of chronic liver diseases.",
        "keywords": [
            "Antibodies",
            "monoclonal",
            "Keratin-18",
            "chronic",
            "Hepatitis B",
            "Apoptosis fragment"
        ],
        "authors": [
            {
                "name": "WEI Fei-li",
                "org": ""
            },
            {
                "name": "SHI Ying",
                "org": ""
            },
            {
                "name": "CHEN Jie",
                "org": ""
            },
            {
                "name": "HU Dong-mei",
                "org": ""
            },
            {
                "name": "LI Qing",
                "org": ""
            },
            {
                "name": "CHEN De-xi",
                "org": ""
            }
        ],
        "venue": "Chinese Journal of Clinicians(Electronic Edition)",
        "year": 2013
    },
    "H3PhGUmB": {
        "id": "H3PhGUmB",
        "title": "The controlled study of application with light and standard polypropylene mesh in tension-free repair of inguinal hernia",
        "abstract": "Objective To evaluate the effect of light polypropylene mesh in tension-free repair of inguinal hernia initially,by the controlled study of application with light and standard polypropylene mesh in herniorrhaphy.Methods A total of 60 patients were divided into 2 groups to receive light polypropylene mesh(experiment group) or standard polypropylene mesh(control group) repair procedure.Data collected included:operation time,postoperative highest temperature and the day of hospital stay;leucocyte count and differential count,the count of CRP,AST,ALT,BUN,Cr in preoperative and postoperative 24 hours;the cases of postoperative complications including wound infection,recurrence,testicular swelling or atrophy, scrotal hydrocele,chronic pain and foreign body feeling.The data were analyzed by statistical method. Results By the statistical analysis,no significant differences were found between the two groups in the operation time,postoperative highest temperature,the day of hospital stay,and the cases of elevated count in postoperative CRP;no significant differences in the leucocyte count,differential count,and the count of AST,ALT,BUN,Cr in preoperative and postoperative 24 hours.During the follow up period of 6 months, there was no wound infection,recurrence,testicular swelling or atrophy in the two groups;There were 2 cases of scrotal hydrocele and 1 case of postoperative chronic pain in experiment group,there were 3 cases of scrotal hydrocele and 3 cases of postoperative chronic pain in control group,by the statistical analysis,no significant differences were found between the two groups;There were 6 patients complained of foreign body feeling in control group,but no one in experiment group,which is statistical significant(P<0.05). Conclusions The application with light polypropylene mesh in tension-free herniorrhaphy is safe and effective. It should diminish the incidence of postoperative foreign body feeling due to the feature of light quality, high porosity and excellent flexibility.",
        "keywords": [
            "Tension-free herniorrhaphy",
            "operative",
            "inguinal",
            "Hernia",
            "Artificial synthetic material",
            "Surgical procedares"
        ],
        "authors": [
            {
                "name": "SHEN Ying-mo",
                "org": ".Center of Hernia and Abdominal Wall Disease,Beijing Chaoyang Hospital,Capital University of Medical Science,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": ".Center of Hernia and Abdominal Wall Disease,Beijing Chaoyang Hospital,Capital University of Medical Science,Beijing ,China"
            },
            {
                "name": "WANG Zhen-jun",
                "org": ".Center of Hernia and Abdominal Wall Disease,Beijing Chaoyang Hospital,Capital University of Medical Science,Beijing ,China"
            },
            {
                "name": "NA Dong-ming",
                "org": ".Center of Hernia and Abdominal Wall Disease,Beijing Chaoyang Hospital,Capital University of Medical Science,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Hernia and Abdominal Wall Surgery",
        "year": 2007
    },
    "BRH2YLLv": {
        "id": "BRH2YLLv",
        "title": "Comparison of new domestic hernia repair piece and similar imported products in applications of inguinal hernia repair",
        "abstract": "Objective To compare the domestic Wuxi Yushou hernia repair piece with similar imported products in the tension-free hernia repair of patients with inguinal hernia and to explore its clinical values in the treatment inguinal hernia.Methods The eligible patients were prospectively randomized into two groups for the Wuxi Yushou hernia repair piece and the control of similar imported patch (30 patients for each group).The clinical parameters before and after surgery in the two groups were recorded.The occurrences of cases of postoperative complications were statistically analyzed.Results The effectiveness,the clinical parameters before and after surgery and the complications after surgery were compared.No differences in operation time,days after hospitalization,short-term effectiveness,clinical parameters before/after surgery and postoperative complications were observed.Conclusions Wuxi Yushou hernia repair piece is a safe and reliable inguinal hernia repair.",
        "keywords": [
            "Herniorrhaphy",
            "inguinal",
            "Hernia",
            "Polypropylenes"
        ],
        "authors": [
            {
                "name": "SUN Li",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "SHEN Ying-mo",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LIU Su-jun",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "WANG Ming-gang",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "WANG Fan",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "ZHU Yi-lin",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "YANG Shuo",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition)",
        "year": 2013
    },
    "R7gwZVWr": {
        "id": "R7gwZVWr",
        "title": "Application of EasyProsthesis \u2161~\ue3eb mesh in tension-free herniorrhaphy for inguinal hernias",
        "abstract": "Objective To evaluate the effect of EasyProsthesis \u2161\ue3eb mesh in tension-free repair of inguinal hernias initially,by the controlled study of application with Ultrapro mesh in herniorrhaphy.Methods A total of 60 patients were divided into 2 groups to receive EasyProsthesis \u2161\ue3eb mesh(experiment group) or Ultrapro mesh(control group) repair procedure.Data collected included:operation time,postoperative highest temperature and the day of hospital stay;leucocyte count and differential count,the count of CRP,AST,ALT,BUN,Cr in preoperative and postoperative 24 hours;the cases of postoperative complications including wound infection,recurrence,testicular swelling or atrophy,scrotal hydrocele,chronic pain and foreign body feeling.The data were analyzed by statistical method.Results By the statistical analysis,no significant differences were found between the two groups in the operation time,postoperative highest temperature,the day of hospital stay,and the cases of elevated count in postoperative CRP;no significant differences in the leucocyte count,differential count,and the count of AST,ALT,BUN,Cr in preoperative and postoperative 24 hours.During the follow up period of 6 months,there was no wound infection,recurrence,chronic pain,testicular swelling or atrophy in the two groups;There were 2 cases of scrotal hydrocele and 6 case of postoperative red swelling of the skin in experiment group,there were 1 cases of scrotal hydrocele and 5 cases of postoperative red swelling of the skin in control group,by the statistical analysis,no significant differences were found between the two groups.Conclusions The application with EasyProsthesis \u2161\ue3eb mesh in tension-free herniorrhaphy is safety and available.",
        "keywords": [
            "Herniorrhaphy",
            "Tension-free",
            "inguinal",
            "Hernia",
            "Postperative complications"
        ],
        "authors": [
            {
                "name": "SHEN Ying-mo",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chao-Yang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chao-Yang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "SUN Li",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chao-Yang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LIU Su-jun",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chao-Yang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "WANG Ming-gang",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chao-Yang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "WANG Fan",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chao-Yang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "YANG Shuo",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chao-Yang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "ZHU Yi-lin",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chao-Yang Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition)",
        "year": 2012
    },
    "sLMxil5E": {
        "id": "sLMxil5E",
        "title": "Small-incision Assisted Laparoscopic Repair for Huge Abdominal Incisional Hernia",
        "abstract": "Objective To summarize our experience in laparoscopic repair of huge abdominal incisional hernia with the assistance of a small incision.Methods From June 2008 to December 2009,we performed small-incision assisted laparoscopy on 15 patients with huge abdominal incisional hernia.The mean diameter of the hernia ring of the patients was(12.3\u00b13.4) cm.After removing the hernial sac,reconstruction of the abdominal wall was carried out.Results The procedure was completed in all the 15 cases within a mean operation time of(123.3\u00b115.9) min(100-150 min).The length of the small incision ranged from 5 to 8 cm with a mean of(6.0\u00b10.9) cm.Hidden hernia was detected in 6 of the cases,and was repaired during the procedure.One patient was confirmed as having a serous cyst.After the operation,the patients was discharged from our hospital in 4 to 8 days with a mean of(5.3\u00b11.2) days.One of the patients had postoperative pain for over three months but without incisional infection or injury to the intestine or other abdominal organs.We followed up the patients for(19.9\u00b14.7) months(12-30 months),and found no recurrent cases.Conclusions Small-incision assisted laparoscopic repair is safe and effective for huge abdominal incisional hernia with less complications and good outcomes in abdominal reconstruction.",
        "keywords": [
            "Huge incisional hernia",
            "Laparoscopy",
            "Small incision",
            "Hernia repair"
        ],
        "authors": [
            {
                "name": "Wang Minggang",
                "org": ",et al.Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "Chen Jie",
                "org": ",et al.Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "Shen Yingmo",
                "org": ",et al.Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Minimally Invasive Surgery",
        "year": 2011
    },
    "uUVyYLJ9": {
        "id": "uUVyYLJ9",
        "title": "Application of medical adhesive in tension-free herniorrhaphy for inguinal hernia.",
        "abstract": "Objective To approach the therapeutic effect of \"Compont\" medical adhesive in tension-free herniorrhaphy for inguinal hernia.Methods A study was performed including 550 cases of inguinal hernia during Jan.2009 and Jun.2009,all operations were performed by the same surgical team.\"Compont\" medical adhesive was used in tension-free hernia repair.Operative time,incidence of postoperative chronic pain and hematoma,recurrence rate,and other complications were recorded.Results In this study,the mean operative time was 33 minutes.There were no wound infection and hematoma after operation.There was no patient complained of chronic pain postoperatively,and there were no recurrences in the duration of follow-up ranged from 6 months to 12 months.Conclusions Application of medical adhesive in tension-free herniorrhaphy for inguinal hernia appears to be associated with a less chronic pain postoperatively,and a lesser incidence of hematoma,and the incidence rate of recurrence was not increased in the cases.The therapeutic effect was safety and available.",
        "keywords": [
            "operative",
            "Medical adhesive",
            "Tension-free",
            "inguinal",
            "herniorrhaphy",
            "Hernia",
            "Surgical procedures"
        ],
        "authors": [
            {
                "name": "SHEN Ying-mo",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chao-Yang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chao-Yang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LIU Su-jun",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chao-Yang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "WANG Ming-gang",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chao-Yang Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Hernia and Abdominal Wall Surgery",
        "year": 2010
    },
    "svD2u4zB": {
        "id": "svD2u4zB",
        "title": "Application of preperitoneal prosthesis with synthetic materials in recurrent inguinal hernia (report of 75 cases)",
        "abstract": "Objective To explore the therapeutic simplicity,safety,and effectiveness of preperitoneal prosthesis with synthetic materials in recurrent inguinal hernia. Methods 75 patients with recurrent inguinal hernia were treated with preperitoneal prosthesis with synthetic material during Feb 2003 to Feb 2005 in our department were retrospectively analyzed to collect data about the operative procedure, complications,average hospital stay and follow-up findings. Results All patients were cured without urinary retention. One patient had wound infection because of subcutaneous heamorrhage at the incision and five patients complicated with scrotal hydrocele. The average operation time was 35 minutes. The average hospital stay was 24 hours after operation. No recurrence and foreign body sensation during a follow-up of 6-30 months. Conclusions Preperitoneal prosthesis with synthetic materials in recurrent inguinal hernia is a technically feasible, safe and clinically effective operative treatment.",
        "keywords": [
            "Recurrent inguinal hernia Tension-free hernia repair Preperitoneal space $$$$"
        ],
        "authors": [
            {
                "name": "Shen Yingmo",
                "org": "Center of Hernia and Abdominal Wall Disease,Beijing Chaoyang Hospital,Beijing "
            },
            {
                "name": "Chen Jie",
                "org": "Center of Hernia and Abdominal Wall Disease,Beijing Chaoyang Hospital,Beijing "
            },
            {
                "name": "Na Dongming",
                "org": "Center of Hernia and Abdominal Wall Disease,Beijing Chaoyang Hospital,Beijing "
            }
        ],
        "venue": "Beijing Medical Journal",
        "year": 2006
    },
    "haMJe7QT": {
        "id": "haMJe7QT",
        "title": "Evidence-based Medicine Applied in Hernia and Abdominal Wall Surgery Teaching",
        "abstract": "Evidence-based medicine(EBM) is different from traditional medicine.It integrates the best medical research results with clinical experience and patient's own value;therefore,it is a new paradigm of clinical medicine.This paper intends to apply the new knowledge,new methods and new technology in hernia and abdominal wall surgery research by combining with EBM concept in the teaching of clinical students so as to train the diagnosis and treatment concepts of modern hernia surgery and produce new-type medical talents.",
        "keywords": [
            "medical education",
            "evidence-based medicine",
            "hernia and abdominal wall surgery"
        ],
        "authors": [
            {
                "name": "SHEN Ying-mo",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital of Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Northwest Medical Education",
        "year": 2010
    },
    "X7s4lku4": {
        "id": "X7s4lku4",
        "title": "Diagnosis of chronic hepatitis' liver fibrosis by microbubble enhanced ultrasound",
        "abstract": "To introduce the researches of evaluation of chronic hepatitis' liver fibrosis levels by ultrasound imagine and hemodynamics indexes in ultrasound examinations with a microbubble ultrasound contrast agent.",
        "keywords": [
            "Contrast agent",
            "Liver fibrosis",
            "Ultrasonography"
        ],
        "authors": [
            {
                "name": "Chen Jie",
                "org": " Beijing You-an hospital affiliate to Capital University of Medical Sciences.Peking ,China"
            },
            {
                "name": "Meng Fankun",
                "org": " Beijing You-an hospital affiliate to Capital University of Medical Sciences.Peking ,China"
            },
            {
                "name": "Chen Xinyue",
                "org": " Beijing You-an hospital affiliate to Capital University of Medical Sciences.Peking ,China"
            }
        ],
        "venue": "Journal of Ultrasound in Clinical Medicine",
        "year": 2006
    },
    "WPQkAP62": {
        "id": "WPQkAP62",
        "title": "Surgical Treatment for Mesh Infection after Prosthetic Patch Repair of Inguinal Hernia",
        "abstract": "Objective To discuss the surgical treatment and experience of mesh infection after prosthetic patch repair of inguinal hernia. Methods The clinical data of 67 cases of mesh infection after prosthetic patch repair who were treated in Chao-Yang Hospital from Jan. 2011 to Jun. 2012 were retrospectively analyzed. Results All patients were treated with surgical operation successfully,including removing the infected mesh and surrounding tissues,primary suture,and a placement of wound drainage,without replacement of a new patch substitute. The hospital stay of the patients was 10-25 days with an average of 16 days. Of the 67 patients,51 patients got primary healed and the other 16 patients healed delayed after local dressing change due to the superficial infection following stitch removal. Sixty-six patients were followed-up for 6-24 months(average of 20 months)after operation without recurrence and complication, including seroma,wound infection,intestinal fistula,and postoperative pain. Conclusions The treatment of mesh infection after inguinal hernia repair is very complicated,but the primary suture repair and a placement of wound drainage after removing infected mesh with complete debridement is a effective therapy for it.",
        "keywords": [
            "Herniorrhaphy",
            "Surgical treatment",
            "Inguinal hernia",
            "Mesh infection"
        ],
        "authors": [
            {
                "name": "SUN Li",
                "org": ""
            },
            {
                "name": "SHEN Ying-mo",
                "org": ""
            },
            {
                "name": "CHEN Jie",
                "org": ""
            },
            {
                "name": "LIU Su-jun",
                "org": ""
            },
            {
                "name": "CHEN Fu-qiang",
                "org": ""
            },
            {
                "name": "YANG Gui-yue",
                "org": ""
            }
        ],
        "venue": "Chinese Journal of Bases and Clinics in General Surgery",
        "year": 2013
    },
    "3B3HljZy": {
        "id": "3B3HljZy",
        "title": "Inguinal hernia repair with acellular tissue matrix patch for pediatric patients aged 6 to 18 years]",
        "abstract": "To evaluate the safety and efficacy of hernioplasty using acellular tissue matrix patch to repair inguinal hernia of pediatric patients aged 6 to 18 years.Sixty eligible patients aged 6 to 18 years with primary unilateral inguinal hernia were randomly assigned to experimental or control group from June to December 2009. In the experimental group, acellular tissue matrix patch was used during Lichtenstein herniorrhaphy while traditional high ligation of hernial sac was used in the control group. Preoperative and postoperative parameters such as clinical informations of patients, postoperative complications and recurrence rate were recorded and analyzed.There were no significant differences between the 2 groups in postoperative length of stay [(31 \u00b1 8) h vs. (34 \u00b1 11) h] and postoperative Visual Analogue Scale Pain Score (2.8 \u00b1 0.9 vs. 2.6 \u00b1 1.0) (P > 0.05), but the operation time in the experimental group were longer than that in the control group significantly [(39 \u00b1 4) min vs. (36 \u00b1 4) min, t = 3.357, P = 0.001]. The duration of follow-up ranged from 14 to 20 months. There were no postoperative incisional infection, chronic postoperative pain and local foreign body sensation in two groups. In the experimental group, 3 patients suffered scrotal hydrocele as compared 2 patients in the control group. There was no recurrence in the experimental group as compared 2 patients (6.7%) in the control group, which was no significant difference (P > 0.05).Lichtenstein repair for pediatric patients aged 6 to 18 years with acellular tissue matrix patch has good results and with limited postoperative complications.",
        "keywords": [
            "Pediatric",
            "Herniorrhaphy",
            "inguinal",
            "Hernia",
            "Acellular tissue matrix"
        ],
        "authors": [
            {
                "name": "Ying-mo Shen",
                "org": "Department of Hernia and Abdominal Wall Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China."
            },
            {
                "name": "Jie Chen",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "Shuo Yang",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "Su-jun Liu",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "Ming-gang Wang",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "Li Sun",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "Fan Wang",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "Yi-Lin Zhu",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition)",
        "year": 2011
    },
    "vCMlztcN": {
        "id": "vCMlztcN",
        "title": "Study of intervention on the disease management of traditional Chinese medicine model on the treatment compliance of patients with depression",
        "abstract": "Objective To observe the influence of the disease management of traditional Chinese medicine model on the the treatment compliance of patients with depression by applying the disease management theory and technology.Methods The patients that went to doctor in depression special clinic of acupuncture and moxibustion department in Beijing hospital of traditional Chinese medicine affiliated to capital medical university from May 2010 to August 2010 were incorporated as the observation object,they were divided into management group(30 cases) and control group(30 cases).The patients who assigned in management group accepted the disease management of traditional Chinese medicine model such as antidepressant medicine treatment,education of traditional Chinese medicine model about depression,regular assessment and following.Conventional treatment model and treatments were used for the control group.The intervention of both group lasted for 24 weeks.The changes in measuring indicators including treatment compliance scale was observed in 4 weeks, 8weeks,12weeks,16 weeks,20 weeks,24 weeks after the intervention in order to observe the measuring indicators of the treatment compliance.Results \u2460The management group had more return visit times and longer treatment time which compared with control group(P<0.01).\u2461The management group had higher compliance of drug treatment,there were more patients taking medicine according to doctor than control group(P<0.05 or P<0.01).\u2462The higher compliance of acupuncture treatment was showed in the management group,there were more patients accepting acupuncture treatment over 3 times every week than control group from 0 to 8 weeks(P<0.01).From 9 to 24 weeks,the persistent acupuncture treatment rate of the management group is higher than the control group(P<0.01).Conclusion The disease management of traditional Chinese medicine model was superior to the conventional treatment model in the treatment compliance.",
        "keywords": [
            "Depression",
            "Disease management of traditional Chinese medicine",
            "Treatment compliance"
        ],
        "authors": [
            {
                "name": "FAN Zhuqing",
                "org": ""
            },
            {
                "name": "PEI Yin",
                "org": "Department of Psychosomatic Medicine,Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical University, Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Department of Psychosomatic Medicine,Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical University, Beijing ,China"
            },
            {
                "name": "YANG Jing",
                "org": "Department of Psychosomatic Medicine,Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical University, Beijing ,China"
            },
            {
                "name": "ZHANG Jie",
                "org": "Department of Psychosomatic Medicine,Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical University, Beijing ,China"
            }
        ],
        "venue": "China Medical Herald",
        "year": 2012
    },
    "EBc0P9rI": {
        "id": "EBc0P9rI",
        "title": "The clinical analysis of tension-free hernia repair in inguinal emergency hernia",
        "abstract": "Objective To study the clinical effect of tension-free hernia repair in inguinal emergency hernia. Methods The tension-free hernia repair was administered in 83 patients with inguinal emergency hernia.All the cases were analyzed retrospectively.Results There were two postoperative deaths in 83 cases within three days after operation.Wound infection occurred in one case.The rest recovered soon.The average stay in hospital was 5.1 days. Conclusion The tension-free hernia repair can be applied to inguinal emergency hernia with satisfactory results.",
        "keywords": [
            "inguinal",
            "Hernia",
            "Reoperation",
            "Tension"
        ],
        "authors": [
            {
                "name": "NA Dong-ming",
                "org": ".The Treatment Center for Hernia and Abdominal Wall Diseases,Beijing Chaoyang Hospital,Capital University of Medical Science,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": ".The Treatment Center for Hernia and Abdominal Wall Diseases,Beijing Chaoyang Hospital,Capital University of Medical Science,Beijing ,China"
            },
            {
                "name": "SHEN Ying-mo",
                "org": ".The Treatment Center for Hernia and Abdominal Wall Diseases,Beijing Chaoyang Hospital,Capital University of Medical Science,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Primary Medicine and Pharmacy",
        "year": 2007
    },
    "2sVDNMYT": {
        "id": "2sVDNMYT",
        "title": "Application of spermatic cord patch in lichtenstein inguinal herniorrhaphy",
        "abstract": "\u3010Objective\u3011 To compare the effectiveness of protective pad of spermatic cord patch and polypropylene mesh in lichtenstein inguinal herniorrhaphy for male patients aged 18 to 40 years.\u3010Methods\u3011 Sixty patients with primary unilateral inguinal hernia were randomly assigned to experimental or control group.In experimental group,protective pad of spermatic cord patch was used in lichtenstein herniorrhaphy while polypropylene mesh was used in the control group.Operation time,postoperative length of stay,postoperative complications and recurrence rate were recorded and analyzed.\u3010Results\u3011 There was no between-group difference in operation time or postoperative length of stay(P >0.05).During the follow-up time ranged from 12 months to 18 months,there was no hernia recurrence,wound infection or testicular swelling/atrophy in the study.In the two groups,there were 3 patients suffered scrotal hydrocele.In the experimental group,no patients experienced local foreign body sensation and painful ejaculation as compared with 6 patients in the control group(P <0.05).\u3010Conclusions\u3011 The use of protective pad of spermatic cord patch for tension-free inguinal herniorrhaphy in the treatment of male patients aged 18 to 40 years is effective and safe.",
        "keywords": [
            "antistick",
            "inguinal",
            "herniorrhaphy",
            "e-PTFE",
            "hernia"
        ],
        "authors": [
            {
                "name": "SUN Li",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chao-Yang Hospital,Capital University of Medical Sciences,Beijing ,P.R.China"
            },
            {
                "name": "CHEN Jie",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chao-Yang Hospital,Capital University of Medical Sciences,Beijing ,P.R.China"
            },
            {
                "name": "SHEN Ying-mo",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chao-Yang Hospital,Capital University of Medical Sciences,Beijing ,P.R.China"
            },
            {
                "name": "LIU Su-jun",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chao-Yang Hospital,Capital University of Medical Sciences,Beijing ,P.R.China"
            },
            {
                "name": "WANG Ming-gang",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chao-Yang Hospital,Capital University of Medical Sciences,Beijing ,P.R.China"
            },
            {
                "name": "WANG Fan",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chao-Yang Hospital,Capital University of Medical Sciences,Beijing ,P.R.China"
            },
            {
                "name": "ZHU Yi-lin",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chao-Yang Hospital,Capital University of Medical Sciences,Beijing ,P.R.China"
            },
            {
                "name": "YANG Shuo",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chao-Yang Hospital,Capital University of Medical Sciences,Beijing ,P.R.China"
            }
        ],
        "venue": "China Journal of Modern Medicine",
        "year": 2012
    },
    "mhMJJncS": {
        "id": "mhMJJncS",
        "title": "Analysis of serum cytokine levels of patients with hepatogenous diabetes and liver cirrhosis",
        "abstract": "Objective To investigate the serum cytokine levels of patients with hepatogenous diabetes and liver cirrhosis. Methods 60 patients with hepatogenous diabetes and liver cirrhosis were enrolled from December 2010 to December 2011 and 60 patients with liver cirrhosis only as control. The serum levels of IL-2,IL-4,IL-6,IL-8,IL-10,INF-\u03b3 and TNF-\u03b1 were tested. Results The serum levels of IL-2,TNF-\u03b1,INF-\u03b3 of the hepatogenous diabetes group were( 57. 2 \u00b1 23. 8) pg / ml,( 48. 2 \u00b1 35. 1) ng / ml,( 89. 2 \u00b1 55. 3) pg / ml,which were higher than that of the control group [( 48. 5 \u00b1 22. 1) pg / ml,( 30. 2 \u00b1 23. 3) ng / ml,( 58. 3 \u00b1 37. 4 ) pg / ml,P < 0. 05]. The serum levels of IL-4,IL-8 of the hepatogenous diabetes group[( 1. 2 \u00b1 0. 5) pg / ml,( 34. 4 \u00b1 16. 7) pg / ml]were lower than that of the control group[( 3. 3 \u00b1 1. 2) pg / ml,( 57. 1 \u00b1 20. 8) pg / ml,P < 0. 05]. There were no significant difference between 2 groups in IL-6 and IL-10 serum levels[( 1. 3 \u00b1 0. 4) pg / ml vs. ( 1. 5 \u00b1 0. 5) pg / ml,( 5. 2 \u00b1 3. 4) pg / ml vs. ( 5. 5 \u00b12. 8) pg/ml,P >0. 05]. Conclusion The unbalance the cytokine network of the patients with hepatogenous diabetes and liver cirrhosis may exacerbate the disease progression.",
        "keywords": [
            "Diabetes mellitus",
            "Cytokines",
            "Liver cirrhosis"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": ". Department of Endocrinology and Hepatology,Youan Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "HUI Wei",
                "org": ". Department of Endocrinology and Hepatology,Youan Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "XU Bin",
                "org": ". Department of Endocrinology and Hepatology,Youan Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LI Xue-mei",
                "org": ". Department of Endocrinology and Hepatology,Youan Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "GUO Xin-hui",
                "org": ". Department of Endocrinology and Hepatology,Youan Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Clinicians(Electronic Edition)",
        "year": 2013
    },
    "uP5z0ldR": {
        "id": "uP5z0ldR",
        "title": "Open Preperitoneal Groin tension-free hernioplasty under local nerve blockade anaesthesia",
        "abstract": "Objective To evaluate the application of open preperitoneal groin tension-free hernioplasty under local nerve blockade anaesthesia. Methods Three thousand one hundred twenty six patients with preperitoneal groin tension-free hernioplasty under local nerve blockade anaesthesia from Feb 2002 to Jan 2008 in our center were analyzed to observe operative time, degree of pain. Results The operative time was 15 to 60 minutes, average time was 25 minutes. All patients had slight wound pain after operation. Three cases died during the stay in hospital, Two cases had the wound infection, no one had urinary retention, the Scrotal hydroceles were 56 cases, the chronic pain was 6 cases. the average stay in hospital were 3 days, the average cost was 4644 Yuan (RMB), 10 cases had recurrence and no one had the feeling of foreign body follow-up average 69 months. Conclusions The open preperitoneal groin tension-free hernioplasty under local nerve blockade anaesthesia was a safe and credible operative method, especially for the old patients with inguinal hernia who has large hernia ring or defect of transversalis fascia (TF).",
        "keywords": [
            "operative",
            "inguinal",
            "Hernia",
            "Surgical procedures",
            "Tension-free hernioplasty",
            "Local nerve blockade anaesthesia"
        ],
        "authors": [
            {
                "name": "YANG Shuo",
                "org": ". Department of Hernia and abdominal wall Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing , China"
            },
            {
                "name": "CHEN Jie",
                "org": ". Department of Hernia and abdominal wall Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing , China"
            },
            {
                "name": "SHEN Ying-mo",
                "org": ". Department of Hernia and abdominal wall Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing , China"
            },
            {
                "name": "LIU Su-jun",
                "org": ". Department of Hernia and abdominal wall Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing , China"
            },
            {
                "name": "WANG Ming-gang",
                "org": ". Department of Hernia and abdominal wall Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing , China"
            },
            {
                "name": "WANG Fan",
                "org": ". Department of Hernia and abdominal wall Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing , China"
            },
            {
                "name": "ZHU Yi-lin",
                "org": ". Department of Hernia and abdominal wall Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing , China"
            },
            {
                "name": "SUN Li",
                "org": ". Department of Hernia and abdominal wall Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing , China"
            }
        ],
        "venue": "Chinese Journal of the Frontiers of Medical Science(Electronic Version)",
        "year": 2010
    },
    "upMciIm1": {
        "id": "upMciIm1",
        "title": "Randomized Controlled Study of Depression Using Disease Management of Traditional Chinese Medicine Model",
        "abstract": "Objective Applying the disease management theory,to explore suitable disease management of traditional Chinese medicine model for depression patients,and observe its role in the therapeutic effects on depression.Methods The patients visiting depression special clinic of acupuncture and moxibustion department in Beijing TCM Hospital,Capital Medical University,from May 2010 to August 2010 were incorporated as the observation object,and were assigned into the management group and control group.The management group accepted the disease management of traditional Chinese medicine model,including antidepressant medicine treatment,education of traditional Chinese medicine model about depression,regular assessment and follow-up.Conventional treatment model and treatments were used for the control group.The intervention of both groups lasted for 24 weeks.The changes in measuring indicators including HAMD and CGI were observed before and at the end of week 4,8,12,16,20,24 of intervention.Results HAMD index showed significant difference at the end of week 12,16,20 and 24 of intervention,the management group was superior to the control group(P <0.05 or P <0.01).CGI index showed significant difference at the end of week 20 and 24 of intervention,the management group was superior to the control group(P <0.05 or P <0.01).Besides,at the end of week 24,the cure rate of the management group was higher than the control group(P <0.05).Conclusion The disease management of TCM model had the same effect in short-term effect as the conventional treatment model,while in long-term effect,the former is superior to the latter.",
        "keywords": [
            "disease management of traditional Chinese medicine",
            "efficacy",
            "depression"
        ],
        "authors": [
            {
                "name": "FAN Zhu-qing",
                "org": "Department of Acupuncture, Fuxing Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Department of Psychosomatic Medicine,Beijing TCM Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "PEI Yin",
                "org": "Department of Psychosomatic Medicine,Beijing TCM Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "YANG Jing",
                "org": "Department of Psychosomatic Medicine,Beijing TCM Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "ZHANG Jie",
                "org": "Department of Psychosomatic Medicine,Beijing TCM Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Information on Traditional Chinese Medicine",
        "year": 2012
    },
    "Y4fyWZdi": {
        "id": "Y4fyWZdi",
        "title": "Application of mesh versus non-mesh surgical patch in the laparoscopic repair",
        "abstract": "Objective To explore the efficacy,safety,complication and shrinkage of mesh and non-mesh surgical patch in the application of transabdominal preperitoneal prosthetic(TAPP).Methods Data of 60 cases with primary inguinal hernia treated with the laparoscopic TAPP herniorrhaphy in our department during Jan 2009 to Jul 2009 were reviewed.The patients were randomized in to two groups to receive mesh and the non-mesh surgical patches in the operation,respectively,and the patients were followed up for 9~14 months.Analysis of the data,including operation duration,postoperative length of stay,cost of hospitalization,postoperative complication,chronic pain,foreign body sensation,recurrence rate and shrinkage.Results It showed that in all of the 60 cases the TAPP was finished,there was no significant difference in operation duration,postoperative length of stay,cost of hospitalization and the occurrence of hematoma between the 2 groups.The chronic pain sensation occurred in 1 case(3.3%) of non-mesh group,which was lower than the surgical mesh group(3 cases,10%),the foreign body sensation occurred in 2 cases(6.7%) of the non-mesh group,which was lower than the surgical mesh group(5 cases,16.7%).The measurement of the meshes' diameter was used to calculate the shrinkage by the ultrasound(post operation 1,3,6,9 months).From the second month after the operation,less shrinkage of non-mesh group than the surgical mesh group was seen(P<0.05).Conclusion The non-mesh patch was more effective and safe than the mesh in TAPP,the non-mesh patch could reduce the occurrence of chronic pain and foreign body sensation,caused less shrinkage.",
        "keywords": [
            "non-mesh surgical patch",
            "inguinal",
            "laparoscopy",
            "hernia"
        ],
        "authors": [
            {
                "name": "WANG Ming-gang",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "SHEN Ying-mo",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "ZHU Yi-lin",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "YANG Shuo",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Journal of Capital Medical University",
        "year": 2011
    },
    "bDjudbUo": {
        "id": "bDjudbUo",
        "title": "Clinical preliminary study on allogeneic acellular dermal matrix patch in tension-free inguinal hernia repair",
        "abstract": "Objective To explore the clinical effect of allogenic acellular dermal matrix in tension-free hernioplasty of inguinal hernia.Methods From June 2010 to June 2011,a total of 50 patients with inguinal hernia in our hospital were treated with allogeneic dermal matrix patch.Preoperative and postoperative parameters such as clinical informations of patients,postoperative complications and recurrence rate were recorded and analysed.Results There were no material hypersensitivity occurred among patients during the followed-up time from 1 to 12 months.One patient suffered incision liquefaction,and there was one case of recurrence,whereas no chronic pain and local foreign body sensation occured.Conclusions Tension-free inguinal hernia repair with allogeneic acellular dermal matrix patch has good results and with limited postoperative complications,and could be applied in the clinical practice as a rational materials.",
        "keywords": [
            "Herniorrhaphy",
            "inguinal",
            "Hernia",
            "Acellular dermal matrix"
        ],
        "authors": [
            {
                "name": "WANG Fan",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "SHEN Ying-mo",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "YANG Shuo",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LIU Su-jun",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "WANG Ming-gang",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "SUN Li",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "ZHU Yi-lin",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Clinicians(Electronic Edition)",
        "year": 2011
    },
    "ZTxts4qX": {
        "id": "ZTxts4qX",
        "title": "The Analysis of Micro-incisional Stoppa Herniorrhaphy for Lumbar Hernia(18 Cases Report)",
        "abstract": "Objective To explore the etiological factors of the lumbar hernia and the security and feasibility of the micro-incisional Stoppa hernioplasty.Methods Retrospective analysis was used in 18 cases of the senile patients with lumbar hernia.10 of the 18 cases had the history of spinal or renal operation,3 had the history of lumbar trauma,1 had the resection history of hypophyseoma and 4 without the history of trauma or operation.9 of the 18 cases had abdominal hypertension.All the cases were treated by the micro-incisional Stoppa under the general anesthesia.Results The mean length of the incision was 6 to 10 cm(average 8.5 cm),the operational duration was 25 to 50 minutes(average 30.1 minutes),and the postoperative length of hospital stay was 3 to 6 days(average 4.5 days).1 case had the postoperative seroma,none of the patients had the incisional pain,infection or perioperative fatality.The postoperative follow-up was 3 to 50 months(average 21.1 months),none of the patients had the recidivation or chronic pain.Conclusions Most of the lumber hernia in old patients are acquired.It is related with the abdominal hypertension,history of the spinal and renal trauma and operation.The Stoppa herniorrhaphy with micro-incision is an anterior approach with simple,safe,effective,economical and practical advantages,which is suitable for the gigantic lumbar hernia in the aged patients.",
        "keywords": [
            "herniorrhaphy",
            "incision",
            "lumber",
            "hernia",
            "aged"
        ],
        "authors": [
            {
                "name": "LIU Su-jun",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital Affiliated to the Capital Medical University,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital Affiliated to the Capital Medical University,Beijing ,China"
            },
            {
                "name": "YANG Shuo",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital Affiliated to the Capital Medical University,Beijing ,China"
            },
            {
                "name": "WANG Ming-gang",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital Affiliated to the Capital Medical University,Beijing ,China"
            },
            {
                "name": "SHEN Ying-mo",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital Affiliated to the Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Modern Operative Surgery",
        "year": 2010
    },
    "5bxhAh7N": {
        "id": "5bxhAh7N",
        "title": "Experience of the laparoscopic high ligation of hernial sac in the treatment of the juvenile patients with inguinal hernia",
        "abstract": "Objective To explore the advantages of the high ligation of hernial sac in the treatment of the juvenile patients with inguinal hernia. Methods Data of 330 juvenile patients(\u22646 years old) with inguinal hernia treated with the laparoscopic high ligation of hernial sac in our department during Jan 2009 to May 2010,including duration of operation,postoperative complication,cost of hospitalization,postoperative length of stay and the follow-up. Results 60 cases contralateral latent hernia was detected during the laparoscopic operation,the duration of operation for the single side was 10 minutes,the mean time of the postoperative food intake was 4 hours,and the postoperative length of stay was 4~24 hours.All the patients had slight postoperative pain,no analgesics were used.Fifty cases had scrotal emphysema,which subsided within 2~3 hours,and there was no relapse,no operative injury,no infectin and postoperative pain occurred.The mean length of stay was 3 days,the mean cost was 3 000 yuan. Conclusion The laparoscopic high ligation of hernial sac is a safe and reliable method,the latent hernia could be detected in the operation,and it is suitable for the juvenile patients(\u22646 years old).",
        "keywords": [
            "inguinal",
            "juvenile",
            "hernia",
            "laparoscope"
        ],
        "authors": [
            {
                "name": "ZHU Yi-lin",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "WANG Ming-gang",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LIU Su-jun",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "SHEN Ying-mo",
                "org": "Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Journal of Capital Medical University",
        "year": 2011
    },
    "4pPDzUUu": {
        "id": "4pPDzUUu",
        "title": "Polypropylene-Prolene Hernia System in the application of tension-free herniorrhaphy of femoral hernia",
        "abstract": "Objective To study the application of Polypropylene-Prolene Hernia System ( PHS) in tension-free herniorrhaphy of femoral hernia. Methods A total of 36 patients with femoral hernia were randomly divided into 2 groups to receive respectively PHS or Plug repair procedure. Data collected included; operative time, hospital stay, postoperative complications and recurrence rate. Results In PHS and Plug groups, the operative time were (42\u00b17) min and (41\u00b14) min respectively, the hospital stay was (4. 1\u00b11. 0) d and (4.4\u00b11. 2) d respectively. During the follow up period from 6 to 30 months,there was no recurrence, one case of scrotal hydrocele in PHS group, and there were two cases of recurrence and one case of ecchymoma in Plug group. Five patients complained of foreign body feeling in Plug group, and no patient in PHS group ( P < 0. 05 ). Conclusions Tension-free herniorrhaphy with PHS is a safe and effective procedure for the treatment of femoral hernia.",
        "keywords": [
            "operative",
            "Hernia",
            "femoral",
            "Surgical procedures",
            "Hemiorrhaphy"
        ],
        "authors": [
            {
                "name": "SHEN Ying-mo",
                "org": ". Center of Hernia and Abdominal Wall Disease, Beijing Chaoyang Hospital, Capital University of Medical Science, Beijing , China"
            },
            {
                "name": "CHEN Jie",
                "org": ". Center of Hernia and Abdominal Wall Disease, Beijing Chaoyang Hospital, Capital University of Medical Science, Beijing , China"
            },
            {
                "name": "WANG Zhen-jun",
                "org": ". Center of Hernia and Abdominal Wall Disease, Beijing Chaoyang Hospital, Capital University of Medical Science, Beijing , China"
            },
            {
                "name": "NA Dong-ming",
                "org": ". Center of Hernia and Abdominal Wall Disease, Beijing Chaoyang Hospital, Capital University of Medical Science, Beijing , China"
            }
        ],
        "venue": "Chinese Journal of General Surgery",
        "year": 2006
    },
    "yWbSkL0P": {
        "id": "yWbSkL0P",
        "title": "The application of artificial synthetic materials in the repair of parastomal hernias with incarceration or strangulation",
        "abstract": "Objective To investigate the rationality and evaluation the effect of artificial synthetic materials in the open repair of parastomal hernias with incarceration or strangulation.Methods To analyze the clinical data of 6 patients with parastomal hernias with incarceration or strangulation,repaired with artificial synthetic materials synchronizationally in Beijing Chaoyang Hospital from March 2006 to September 2007 retrospectively.Results All the patients were cured without death or infection of abdominal cavity.One case by preperitoneal repair with polypropylene mesh occurred infection of incisional wound,taken out of the mesh after 20 days,and was cured by normal position intraperitoneal tension-free repair.One case occurred fat colliquation in incisional wound,and was cured by change of dressing in short time.The operation time was120 to 160 min(average was 130 min),the hospital stay was12 to 35 d(average was 17d).During the follow up period of 3 to 21 months(average was 11 months),there was no inchoate recurrence.Conclusions Selective application of artificial synthetic materials in treatment of parastomal hernias with incarceration or strangulation was safe and feasible.",
        "keywords": [
            "Repair with artificial synthetic material",
            "Hernia",
            "Postoperative complications"
        ],
        "authors": [
            {
                "name": "LIU Su-jun",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "SHEN Ying-mo",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "GAO Guo-dong",
                "org": ".Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Hernia and Abdominal Wall Surgery",
        "year": 2008
    },
    "v2zylHOd": {
        "id": "v2zylHOd",
        "title": "Open preperitoneal groin tension-free hernioplasty",
        "abstract": "Objective To evaluate the application of open preperitoneal groin tension-free hernioplasty.Methods 150 patients with preperitoneal groin tensionfree hernioplasty under local nerve blockade anaesthesia from Mar 2006 to Apr 2007 in our center were analyzed.Results Non cases was died during the stay in hospital,the operative time was 15 to 60 minutes,average time was 25 minutes.All patients had slight wound pain after operation,no one used anesthetic.no case had the wound infective,no one had urinary retention,the Scrotal hydroceles were 0 case,the chronic pain was 0 case.the average stay in hospital were 3 days,the average cost was 4266 yuan(RMB),no case had recurrence and no one had the feeling of foreign body follow-up average 16 months.Conclusion The open preperitoneal groin tension-free hernioplasty under local nerve blockade anaesthesia is a safe and credible operative method,especially for the inguinal hernia who has large hernia ring or defect of transversalis fascia(TF) and recurrence hernia.",
        "keywords": [
            "operative",
            "inguinal",
            "Hernia",
            "Surgical procedures",
            "Tension-free hernioplasty",
            "Local nerve blockade anaesthesia"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": ""
            },
            {
                "name": "SHEN Ying-mo",
                "org": ""
            },
            {
                "name": "LIU Su-jun",
                "org": ""
            },
            {
                "name": "NA Dong-ming",
                "org": ""
            },
            {
                "name": "WANG Fan",
                "org": ""
            }
        ],
        "venue": "Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Version)",
        "year": 2008
    },
    "MddZKfLO": {
        "id": "MddZKfLO",
        "title": "Genetic Polymorphisms of the MxA Promoter-88 Site and Response to Interferon Treatment in Hepatitis B Patients",
        "abstract": "Objective To identify the host single nucleotide polymorphisms(SNP) of the MxA promoter 88 site and predict interferon response in hepatitis B patients.Methods 262 chronic hepatitis B patients were treated with \u03b1-IFN for 1 year.Single nucleotide polymorphisms of the MxA promoter-88 site were examined by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) and were compared with the responsiveness of hepatitis B patients to IFN.Results 212 cases were no sustained response(NSR);50 with sustained response(SR).The SNP of MxA promoter-88 was found having a significant difference in the genotypic frequency distribution between SR and NSR patients.The rate of GT heterozygote was 50.0% in SR and 17.5% in NSR,P<0.01.Conclusion Patients with GT genotype at MxA promoter-88 responds well to IFN treatment.",
        "keywords": [
            "single nucleotide polymorphisms(SNP)",
            "chronic hepatitis B",
            "MxA",
            "interferon"
        ],
        "authors": [
            {
                "name": "Huang Yanxiang",
                "org": "Beijing You'an Hospital,Capital University of Medical Sciences"
            },
            {
                "name": "Chen Xinyue",
                "org": "Beijing You'an Hospital,Capital University of Medical Sciences"
            },
            {
                "name": "Li Zhuo",
                "org": "Hepatitis Institute Beijing Municipal Health Bureau"
            },
            {
                "name": "Liu Linhua",
                "org": "Beijing You'an Hospital,Capital University of Medical Sciences"
            },
            {
                "name": "Chen Jie",
                "org": "Beijing You'an Hospital,Capital University of Medical Sciences"
            }
        ],
        "venue": "Journal of Capital University of Medical Sciences",
        "year": 2006
    },
    "HxmwZHAf": {
        "id": "HxmwZHAf",
        "title": "Application of artificial synthetic material in the repairing of umbilical hernia in adults:a report of 52 cases",
        "abstract": "Objective To evaluate the application of artificial synthetic material mesh in the repairing of umbilical hernia in adults.Methods Fifty-two cases of adult patients with umbilical hernia admitted between January 2001 and June 2005 in the Treatment Center for Hernia and Abdominal Wall Diseases of Beijing Chaoyang Hospital of Capital University of Medical Science were analyzed retrospectively in terms of methods,characteristics and effects of synthetic material mesh in the repairing of umbilical hernia in adults.Results All cases were cured.The average stay in hospital was 10 days (6 days after operation).The postoperative complications included:wound infection (1 case),wound skin necrosis (1 case),hypodermal seroma (1 case).No recurrence was followed up during 2-54 months.Conclusion Repairing umbilical hernia in adults with artificial synthetic material mesh is a kind of safe,effective operation.It should be performed correctly and on case-to-case basis.",
        "keywords": [
            "Herniorrhaphy",
            "Umbilical hernia",
            "Artificial synthetic material"
        ],
        "authors": [
            {
                "name": "Na Dongming",
                "org": ".Treatment Center for Hernia and Abdominal Wall Diseases,Beijing Chaoyang Hospital,Capital University of Medical Science,Beijing ,China"
            },
            {
                "name": "Chen Jie",
                "org": ".Treatment Center for Hernia and Abdominal Wall Diseases,Beijing Chaoyang Hospital,Capital University of Medical Science,Beijing ,China"
            },
            {
                "name": "Shen Yingmo",
                "org": ".Treatment Center for Hernia and Abdominal Wall Diseases,Beijing Chaoyang Hospital,Capital University of Medical Science,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Practical Surgery",
        "year": 2006
    },
    "tIVAMMrd": {
        "id": "tIVAMMrd",
        "title": "Analysis of hepatitis B virus core promoter mutations in liver tissues of patients with hepatocellular carcinoma",
        "abstract": "Objective To explore hepatitis B virus(HBV)core promoter mutations in the liver tissue of hepatocellular carcinoma(HCC)patients and compare with liver cirrhosis(LC)and chronic hepatitis B(CHB).Methods HBV pre-C and core promoter(CP)regions in the liver tissues of 52 HCC,45 LC and 25 CHB patients were cloned and sequenced,and then the core promoter mutations were analyzed.Results Comparing to CHB and LC,HCC patients had a higher proportion of G1613A,A1727C,A1762T,G1764A and 1896A mutations(P<0.05).The mutation rate of the core promoter regulatory regions in HCC group was significantly higher than that in the LC and CHB groups(P<0.05).Conclusions Our histology data support that the HBV core promoter region mutations in the HCC group are at a higher prevalence;A1762T/G1764A double mutations can be used as a predictor of HCC.",
        "keywords": [
            "Hepatitis B virus",
            "Liver tissues",
            "Mutation",
            "Core promoter"
        ],
        "authors": [
            {
                "name": "WEI Fei-li",
                "org": "*Key Laboratory of Beijing You\u2032an Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "SHI Ying",
                "org": "*Key Laboratory of Beijing You\u2032an Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LI Qing",
                "org": "*Key Laboratory of Beijing You\u2032an Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LIU Ya-li",
                "org": "*Key Laboratory of Beijing You\u2032an Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "*Key Laboratory of Beijing You\u2032an Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "CHEN De-xi",
                "org": "*Key Laboratory of Beijing You\u2032an Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "WU Hao",
                "org": "*Key Laboratory of Beijing You\u2032an Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Viral Diseases",
        "year": 2013
    },
    "ZXOCSmlF": {
        "id": "ZXOCSmlF",
        "title": "Clinical Experience on Local Nerve Blockade Anaesthesia for Tension-free Inguinal Hernia Repairing in the Senile Patients",
        "abstract": "Objective To evaluate the curative effect of local nerve blockade anaesthesia for tension-free inguinal hernia repairing in senile patients.Methods 3 257 senile patients with tension-free hernioplasty under local nerve blockade anaesthesia from Feb 2002 to Jun 2008 in our center were analyzed.Results The operative time was 18 to 50 minutes at average time 28 minutes.All patients had good anaesthetic condition and no urinary retention,except one case with infective wound,36 cases with scrotal hydrocles and 5 cases with chronic pain.The average stay in hospital was 2.9 days,and the average cost was 4 267 yuan(RMB).4 cases had recurrence and no one had the feeling of foreign body follow-up in an average of 48 months.Conclusion The open groin tension-free hernioplasty under local nerve blockade anaesthesia is a safe and credible operation procedure.",
        "keywords": [
            "senile patients",
            "local nerve blockade anaesthesia",
            "tension-free hernioplasty",
            "inguinal hernia"
        ],
        "authors": [
            {
                "name": "Wang Minggang",
                "org": "Department of Hernia and Abdominal Wall Disease Surgery,Beijing Chaoyang Hospital,Capital Medical University"
            },
            {
                "name": "Chen Jie",
                "org": "Department of Hernia and Abdominal Wall Disease Surgery,Beijing Chaoyang Hospital,Capital Medical University"
            },
            {
                "name": "Liu Sujun",
                "org": "Department of Hernia and Abdominal Wall Disease Surgery,Beijing Chaoyang Hospital,Capital Medical University"
            },
            {
                "name": "Shen Yingmo",
                "org": "Department of Hernia and Abdominal Wall Disease Surgery,Beijing Chaoyang Hospital,Capital Medical University"
            },
            {
                "name": "Bao Shaoyu",
                "org": "Department of Hernia and Abdominal Wall Disease Surgery,Beijing Chaoyang Hospital,Capital Medical University"
            },
            {
                "name": "Zhu Dawei",
                "org": "Department of Hernia and Abdominal Wall Disease Surgery,Beijing Chaoyang Hospital,Capital Medical University"
            }
        ],
        "venue": "Journal of Capital Medical University",
        "year": 2008
    },
    "dxftbW5I": {
        "id": "dxftbW5I",
        "title": "Lichtenstein repair of indirect inguinal hernias with acellular tissue matrix grafts in adolescent patients: a prospective, randomized, controlled trial.",
        "abstract": "To evaluate the outcomes of Lichtenstein hernioplasty using acellular tissue matrix (ACTM) grafts in adolescent patients.One hundred patients, 13-18 years old, with primary unilateral indirect inguinal hernias, were randomly assigned to receive Lichtenstein hernioplasty using ACTM or traditional high ligation of the hernia sac (control group).The outcome measures were the length of the operation, postoperative visual analogue scale (VAS) pain score, length of hospitalization, postoperative complications and recurrence rate.The length of hospitalization and VAS score were not different between the groups, and the minimum follow-up was 30 months. No postoperative wound infections, chronic postoperative pain or local foreign body sensation occurred in either group. Six patients (14.3 %) in the experimental group and five (11.6 %) in the control group developed scrotal hydroceles (P > 0.05); all resolved with conservative management. There were no recurrences in the experimental group, while there were three (6 %) in the control group (P > 0.05) and all occurred in patients with Gilbert type 3 hernias.Lichtenstein hernioplasty using ACTM grafts has comparable safety and efficacy to traditional high ligation of the indirect hernia sac in adolescent patients. ACTM can reduce the incidence of recurrence in adolescents with Gilbert type 3 hernias.",
        "keywords": [
            "Hernia",
            " Inguinal",
            " Herniorrhaphy",
            " Adolescent",
            " Acellular tissue matrix"
        ],
        "authors": [
            {
                "name": "Ying-mo Shen",
                "org": "Department of Hernia and Abdominal Wall Surgery, Beijing Chao-Yang Hospital, Capital Medical University, 5 Jingyuan Road, Shijingshan District, Beijing, 100043, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Hernia and Abdominal Wall Surgery, Beijing Chao-Yang Hospital,Capital Medical University,Beijing,China"
            },
            {
                "name": "Mao-lin Tian",
                "org": "Department of Hernia and Abdominal Wall Surgery, Beijing Chao-Yang Hospital,Capital Medical University,Beijing,China"
            },
            {
                "name": "Shuo Yang",
                "org": "Department of Hernia and Abdominal Wall Surgery, Beijing Chao-Yang Hospital,Capital Medical University,Beijing,China"
            },
            {
                "name": "Su-jun Liu",
                "org": "Department of Hernia and Abdominal Wall Surgery, Beijing Chao-Yang Hospital,Capital Medical University,Beijing,China"
            },
            {
                "name": "Ming-gang Wang",
                "org": "Department of Hernia and Abdominal Wall Surgery, Beijing Chao-Yang Hospital,Capital Medical University,Beijing,China"
            }
        ],
        "venue": "Surgery today",
        "year": 2014
    },
    "3upgzNEb": {
        "id": "3upgzNEb",
        "title": "Application of Laparoscopic Transabdominal Preperitoneal Hernia Repair for Recurrent Inguinal Hernia",
        "abstract": "Objective To explore the surgical techniques and the clinical effect of laparoscopic transabdominal preperitoneal(TAPP)hernia repair for recurrent inguinal hernia. Methods Clinical data of 130 cases of recurrent inguinal hernia who underwent TAPP hernia repair from Mar. 2009 to Dec. 2012 in Beijing Chao-Yang Hospital of Capital Medical University were retrospectively analyzed. Results Operations were completed successfully in 129 cases and 1 case was converted to open surgery. The operation time was(54.5\u00b116.1)min(30-100 min)and the hospital stay was(4.5\u00b12.1)d(2-11 d). The rates of postoperative pain,hydrocele,and urinary retention were 3.8%(5/130),11.5%(15/130),and 1.5%(2/130)respectively. There were no complications such as foreign body sensation,wound infection,and intestinal obstruction after operation. All cases were followed-up for 7-50 months\u3014(24.3\u00b111.3)months)\u3015with no recurrence was observed. Conclusions Laparoscopic TAPP hernia repair for recurrent inguinal hernia has advantages of minimal invasion and few complications,who is safe and effective.",
        "keywords": [
            "Laparoscopy",
            "Inguinal hernia",
            "Transabdominal preperitoneal hernia repair",
            "Recurrence"
        ],
        "authors": [
            {
                "name": "ZHAO Xue-fei",
                "org": ""
            },
            {
                "name": "NIE Yu-sheng",
                "org": ""
            },
            {
                "name": "LIU Jing",
                "org": ""
            },
            {
                "name": "WANG Ming-gang",
                "org": ""
            },
            {
                "name": "CHEN Jie",
                "org": ""
            }
        ],
        "venue": "Chinese Journal of Bases and Clinics in General Surgery",
        "year": 2013
    },
    "JGiBQ7GA": {
        "id": "JGiBQ7GA",
        "title": "The application of laparoscopic hernia repair with a subsidiary mini-incision for large parastomal hernias",
        "abstract": "Objective: To explore the clinical effect and the experience of laparoscopic hernia repair with a subsidiary mini-incision for large parastomal hernias.Methods: The clinical data of 37 patients with large parastomal hernia who underwent laparoscopic hernia repair with a subsidiary mini-incision from Aug.2008 to Dec.2010 were retrospectively analyzed,and reviewed the operational duration,missed hernia,length of the incision,the length of stay,wound infection,serumal cyst,chronic pain and recurrence.Results: All of the 37 cases underwent smooth operations.The mean operation time was(127.97 \u00b1 18.54) min,and the average length of the incision were(5.89 \u00b1 1.02) cm,and 12 cases of missed hernia were founded in the operation,and 3 cases of intestinal injury were repaired intraoperatively,and there was no operative fatality.The mean postoperative length of stay were(5.35 \u00b1 1.27) d,and 3 case had the postoperative pain lasted 3 months,and 4 case had the postoperative serumal cyst,and there was no incisional infection.All the cases had the follow-up of 6-30 m and no recurrence was observed.Conclusions: Laparoscopic hernia repair with a subsidiary mini-incision could be an effective and safe method.It can reduce the incidence of the postoperative complication.",
        "keywords": [
            "Micro-incision",
            "Herniorrhaphy",
            "Parastomal hernia",
            "Case reports",
            "Laparoscopy"
        ],
        "authors": [
            {
                "name": "WANG Ming-gang",
                "org": ",et al.Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital Affiliated the Capital Medical University,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": ",et al.Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital Affiliated the Capital Medical University,Beijing ,China"
            },
            {
                "name": "ZHAO Xue-fei",
                "org": ",et al.Department of Hernia and Abdominal Wall Surgery,Beijing Chaoyang Hospital Affiliated the Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Journal of Laparoscopic Surgery",
        "year": 2012
    },
    "6cZmxcXy": {
        "id": "6cZmxcXy",
        "title": "Effect of Interferon\u03b1-2b Combined with Lamivudine in Positive HBeAg Chronic Hepatitis B Children",
        "abstract": "Objective To study the effect of lamivudine and combined treatment of children with HBeAg positive chronic hepatitis B.Methods 97 children with HBsAg,HBeAg,HBV-DNA positive chronic hepatitis B were divided into 3 groups:lamivudine treatment group(n=35);Interferon-\u03b12b treatment group(n=28),lamivudine and Interferon-\u03b12b combined treatment group(n=34).All patients had been treated for 48 weeks. Blood routine,liver function,HBV serology,HBV-DNA and side-effects were detected. Results Higher percentage of HBeAg/HBeAb conversation and HBV-DNA clearance in lamivudine and Interferon-\u03b12b combined treatment group was achieved than the other groups after 48 weeks\u2019 treatment. After 48 weeks\u2019treatment,the percentage of HBeAg/ HBeAb conversation in combined treatment group was higher than the others. The percentage of HBV-DNA clearance higher than Interferon-\u03b12b group, but is not different from the lamivudine group. Conclusion Superior to Interferon-\u03b12b or lamivudine alone,Interferon-\u03b12b combined with lamivudine is more effective for e-system conversation of HBeAg positive chronic hepatitis B children.",
        "keywords": [
            "Interferon",
            "Hepatitis B",
            "Lamivudine",
            "Children",
            "Treatment"
        ],
        "authors": [
            {
                "name": "HE Shijuan",
                "org": " Second People\u2019s Hospital of Yibin City,Yibin "
            },
            {
                "name": "CHEN Jie",
                "org": " Beijing You\u2019an Hospital,Capital Medical University,Beijing "
            }
        ],
        "venue": "China Modern Doctor",
        "year": 2008
    },
    "h6C7U8Vk": {
        "id": "h6C7U8Vk",
        "title": "Analysis of consultation characteristics for elderly patients in the department of psychosomatic medicine in Hospital of TCM",
        "abstract": "Objective To analyze the characteristics of consultatioti for elderly patients in the department of psychosomatic medicine of our hospital.Methods 157 elderly patients accepting consultation in the department of psychosomatic medicine were analyzed.The aspects of analysis included the departments and reasons for consultations,and diagnoses after consultation.Results The most common diseases were cardiovascular,cerebrovascular and digestive diseases in elderly patients complicated with mental disorders;the most common reason for consultation is associated with sleep disorders;the most common diagnoses of consultation is the mixed anxiety-depressive disorder;high risk of delirium was increased in elderly patients.Conclusion Diagnosis and treatment of psychiatric-related diseases provided by the department of psychosomatic medicine for many patients,at the same time,Consultation in Dept.of Psychiatry is also necessary.Therefore, the department of psychosomatic medicine as a bridge can strengthen the link providing comprehensive services for patients.",
        "keywords": [
            "delirium",
            "anxiety",
            "psychosomatic medicine",
            "mental disorders",
            "referral and consultation"
        ],
        "authors": [
            {
                "name": "PEI Yin",
                "org": "Department of Psychosomatic Medicine,Beijing Hospital of Traditional Chinese Medicine, Capital Medical University,Beijing ,China"
            },
            {
                "name": "ZHANG Jie",
                "org": "Department of Psychosomatic Medicine,Beijing Hospital of Traditional Chinese Medicine, Capital Medical University,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Department of Psychosomatic Medicine,Beijing Hospital of Traditional Chinese Medicine, Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Geriatric Heart Brain and Vessel Diseases",
        "year": 2012
    },
    "qSzTn8mL": {
        "id": "qSzTn8mL",
        "title": "Open Preperitoneal Groin tension-free hernioplasty under local nerve blockade anaesthesia",
        "abstract": "Objective To evaluate the application of open preperitoneal groin tension-free hernio- plasty under local nerve blockade anaesthesia.Methods One thousand seven hundreds twenty three pa- tients with preperitoneal groin tension-free hernioplasty under local nerve blockade anaesthesia from Feb 2002 to Jun 2006 in our center were analyzed.Results The operative time was 15 to 60 minutes,average time was 28 minutes.All patients had slight wound pain after operation,no one used anesthetic.Three cases was died during the stay in hospital,One case had the wound infection,no one had urinary retention,the Scrotal hydroceles were 46 cases,the chronic pain was 5 cases.the average stay in hospital were 3 days,the aver- age cost was 4766 yuan (RMB),4 cases had recurrence and no one had the feeling of foreign body follow-up average 45 months.Conclusions The open preperitoneal groin tension-free hemioplasty under local nerve blockade anaesthesia was a safe and credible operative method,especially for the old patients with inguinal hernia who has large hernia ring or defect of transversalis fascia (TF).",
        "keywords": [
            "operative",
            "inguinal",
            "Hernia",
            "Surgical procedures",
            "Tension-free hernioplasty",
            "Local nerve blockade anaesthesia"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": ".The treatment center of hernia and abdominal wall disease of Beijing ChaoYang Hospital affiliated The Capital Medical University,Beijing ,China"
            },
            {
                "name": "NA Dong-ming",
                "org": ".The treatment center of hernia and abdominal wall disease of Beijing ChaoYang Hospital affiliated The Capital Medical University,Beijing ,China"
            },
            {
                "name": "SHEN Ying-mo",
                "org": ".The treatment center of hernia and abdominal wall disease of Beijing ChaoYang Hospital affiliated The Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Version)",
        "year": 2007
    },
    "Atl7fC9Q": {
        "id": "Atl7fC9Q",
        "title": "Open artificial syuthetic material herniorrhaphy to com latro hernia 27 cases to understand",
        "abstract": "Objective To evaluate the treatment of the operation method and the surround time of operation in patients with parastomal hernia.Methods To analyze the clinical data of 27 patients with parastomal hernia received open artificial synthetic material herniorrhaphy in Beijing Chaoyang Hospital from Dec.2005 to Jun.2007 retrospectively.Results During the follow up period of 6 to 24 months,there were 1 case of recurrence,2 cases of fat colliquation in incision.Conclusions Open artificial synthetic material herniorrhaphy is a safe and effective surgical procedure with low recurrence rate.",
        "keywords": [
            "Herniorrhaphy",
            "Hernia",
            "Artificial synthetic material",
            "Surgical interention"
        ],
        "authors": [
            {
                "name": "QIAO Yong-zhong",
                "org": ".Department of General Surgery,the Second People's Hospital of Heze,Heze ,China"
            },
            {
                "name": "CHEN Jie",
                "org": ".Department of General Surgery,the Second People's Hospital of Heze,Heze ,China"
            },
            {
                "name": "SHEN Ying-mo",
                "org": ".Department of General Surgery,the Second People's Hospital of Heze,Heze ,China"
            },
            {
                "name": "LIU Su-jun",
                "org": ".Department of General Surgery,the Second People's Hospital of Heze,Heze ,China"
            }
        ],
        "venue": "Chinese Journal of Hernia and Abdominal Wall Surgery",
        "year": 2008
    },
    "wJKrSHy4": {
        "id": "wJKrSHy4",
        "title": "Open preperitoneal groin tension-free hernioplasty under local nerve blockade anaesthesia with EasyProsthesis MESH",
        "abstract": "Objective To evaluate the curative effect of open preperitoneal groin tension-free hernioplasty under local nerve blockade anaesthesia with EasyProsthesis MESH.Methods 68 patients with preperitoneal groin tension-free hernioplasty under local nerve blockade anaesthesia with EasyProsthesis MESH were analyzed: anesthetic effect,operation time,hospitalization time,hospital fees and the follow-up complications and recuirences after surgery.Results All patients were repaired with local nerve blockade anaesthesia;the operation time was 30 to 45 minutes;meanly 35 minutes.Just 3 patients had slight wound pain after operation,all of whom were young patients.The average time patients stayed in hospital was 2 to 3 days,there were 2 patients suffered with scrotal hematoma and no one felt foreign body sensation,norecurrences followed-up for average 10 months.Conclusions The open preperitoneal tension-free hernioplasty with EasyProsthesis MESH is the way of repairing myopectineal orifice,and it has the benefit of large repairing extent,rapid recover after operation,few complications,short time in hospital and low recurrences.So compared with traditional surgery,this is a more ideal surgical method.",
        "keywords": [
            "EasyProsthesis MESH",
            "Anesthesia",
            "Hernia",
            "iguinal",
            "local",
            "Tension-free hernioplasty"
        ],
        "authors": [
            {
                "name": "LONG Ya-xin",
                "org": ",Department of General Surgery,the First Hospital of Yunnan,Kunming ,China"
            },
            {
                "name": "CHEN Jie",
                "org": ",Department of General Surgery,the First Hospital of Yunnan,Kunming ,China"
            },
            {
                "name": "LIU Su-jun",
                "org": ",Department of General Surgery,the First Hospital of Yunnan,Kunming ,China"
            },
            {
                "name": "SHEN Ying-mo",
                "org": ",Department of General Surgery,the First Hospital of Yunnan,Kunming ,China"
            },
            {
                "name": "WANG Ming-gang",
                "org": ",Department of General Surgery,the First Hospital of Yunnan,Kunming ,China"
            }
        ],
        "venue": "Chinese Journal of Hernia and Abdominal Wall Surgery",
        "year": 2009
    },
    "QwE4HKjL": {
        "id": "QwE4HKjL",
        "title": "The comparative study between compont medical adhesive and auto-suture tacks in the meshes\u2019 fixation of TAPP",
        "abstract": "Objective To investigate the safety and availability of compont medical adhesive in the meshes\u2019 fixation of TAPP. Methods Sixty cases of primary inguinal hernia treated by the TAPP in our department during Jan to Jul 2009 were reviewed. A control study in the operation between compont medical adhesive and auto-suture tacks was carried out and all were follow-up for 7~14 months. Results Both of the two groups had no relapse. Hematoma occurred in two case of auto-suture tacks group and one in the compont medical adhesive group. Pain experienced in the auto-suture tacks group in one or none in the compont medical adhesive group. The operative time in the auto-suture tacks group was (37\u00b110)min and the compont medical adhesive group was (55\u00b110)min(P = 0.036). The postoperative length of stay in the auto-suture tacks group was (3.2\u00b11.3) days and the compont medical adhesive group was (2.9\u00b11.2) days, without significant difference (P = 0.231). The cost of hospitalization in the auto-suture tacks group was (9267\u00b1785)yuan and the compont medical adhesive group was (6542\u00b1863)yuan (P = 0.000). There were more cases with postoperative pain in the auto-suture tacks group than the compont medical adhesive group (P \u2264 0.05). Conclusions The appliacation of the compont medical adhesive in the TAPP has hemostasis effect and can reduce the occurrence of postoperative hematoma and pain. It is a safe and available treatment approach.",
        "keywords": [
            "Compont medical adhesive",
            "Laparoscope",
            "Hernia",
            "Inguinal"
        ],
        "authors": [
            {
                "name": "WANG Ming-gang",
                "org": "Department of Hernia and Abdominal Wall Surgery, Beijing Chaoyang Hospital, Beijing "
            },
            {
                "name": "CHEN Jie",
                "org": "Department of Hernia and Abdominal Wall Surgery, Beijing Chaoyang Hospital, Beijing "
            },
            {
                "name": "SHEN Ying-mo",
                "org": "Department of Hernia and Abdominal Wall Surgery, Beijing Chaoyang Hospital, Beijing "
            }
        ],
        "venue": "Beijing Medical Journal",
        "year": 2010
    },
    "WRcE1TyF": {
        "id": "WRcE1TyF",
        "title": "Clinical control study of unbraid mesh vs braid mesh for inguinal hernia repair by the TAPP.",
        "abstract": "objective To approach the safety,availability and postoperative complications of original unbraid mesh vs braid mesh for inguinal hernia repair by the TAPP.Methods A randomized control study was performed including 57 cases(70 sides of hernia) hernia repair of TAPP during Jan.2009 and Jul.2009,32 cases of hernia repaired by original unbraid mesh and 38 cases by braid mesh.Analysis the patients' data,including operative time,length of stay,cost of hospitalization,incidence rate of the perioperative complications,postoperative follow-up of the chronic pain,incidence rate of foreign body sensation and the recrudescence of short-term, the cases were followed-up for 3 to 6 months.Results 57 cases without transfered to open procedure,the operative mean time of the 32 cases of hernia repaired by original unbraid mesh was 41minutes and that of 38 cases by braid mesh was 37minutes,the lengths of stay were 1.8 days and 2.1 days,and the mean operative costs of each side were 9135 yuan and 8867 yuan respectively.The incidence rates of the perioperative complications were 15.6% and 15.7%,the incidence rates of chronic postoperative pain were 3.1 % and 7.8%,the incidence rates of foreign body sensation were 3.1 % and 10.5 %,both of the two group without recrudescence.Conclusions The TAPP by unbraid mesh and braid mesh was safety and available.The incidence rates of chronic postoperative pain and foreign body sensation were lower in the cases repaired by the original unbraid mesh.",
        "keywords": [
            "Unbraid mesh",
            "Herniorrhaphy",
            "inguinal",
            "Hernia",
            "Laparoscopes"
        ],
        "authors": [
            {
                "name": "WANG Ming-gang",
                "org": ".Department of hernia and abdominal wall surgery,Beijing Chao Yang Hospital.Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": ".Department of hernia and abdominal wall surgery,Beijing Chao Yang Hospital.Beijing ,China"
            },
            {
                "name": "SHEN Ying-mo",
                "org": ".Department of hernia and abdominal wall surgery,Beijing Chao Yang Hospital.Beijing ,China"
            },
            {
                "name": "ZHU Yi-lin",
                "org": ".Department of hernia and abdominal wall surgery,Beijing Chao Yang Hospital.Beijing ,China"
            },
            {
                "name": "YANG Shuo",
                "org": ".Department of hernia and abdominal wall surgery,Beijing Chao Yang Hospital.Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Hernia and Abdominal Wall Surgery",
        "year": 2010
    },
    "jKg06342": {
        "id": "jKg06342",
        "title": "The experiences of tension-free hernia repair to inguinal incarcerated hernia under local nerve blockade anaesthesia",
        "abstract": "Objective To discuss the value of tension-free hernia in inguinal incarcerated hernia under local nerve blockade anaesthesia.Methods The clinical data of 20 patients with inguinal incarcerated hernia treated with tension-free hernia repair between 2007 and 2009 was retrospectively analyzed.Results All cases were operated successfully.The mean operation time was 45min.2 cases of postoperative pain and 2 cases of scrotal hydrocele.after operation.All patients were followed up for 2 months to 2 years,no recurrence.Conclusions Application of tension-free hernia repair in inguinal incarcerated hernia under local nerve blockade anaesthesia is an effective surgical method.",
        "keywords": [
            "operative",
            "inguinal",
            "Hernia",
            "Surgical procedures",
            "Tension-free hernioplasty",
            "Incarceration"
        ],
        "authors": [
            {
                "name": "LI Rong-lin",
                "org": ".Second Division Ninghe hospitals,Tianjin,,China"
            },
            {
                "name": "CHEN Jie",
                "org": ".Second Division Ninghe hospitals,Tianjin,,China"
            },
            {
                "name": "LIU Su-jun",
                "org": ".Second Division Ninghe hospitals,Tianjin,,China"
            },
            {
                "name": "SHEN Ying-mo",
                "org": ".Second Division Ninghe hospitals,Tianjin,,China"
            },
            {
                "name": "WANG Ming-gang",
                "org": ".Second Division Ninghe hospitals,Tianjin,,China"
            }
        ],
        "venue": "Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition)",
        "year": 2010
    },
    "jOkTmu0Q": {
        "id": "jOkTmu0Q",
        "title": "An Optimization Algorithm of Pallottino Implemented with Two Queues in Transportation Network",
        "abstract": "The shortest path problem,in which label algorithms are of consequence,is a research topic in the field of geographic information science and computer science.Among label algorithms,label setting algorithms in which Dijkstra occupies the core position are always considered as the first choice in applications while label correcting algorithms are rarely used.In this paper,followed by the theory expatiation on label correcting algorithms,an optimization of the well-known Pallottino algorithm is set forward on the basis of both storage and implementation structures.The author then analyzes its time complexity and spatial complexity and finally tests its actual efficiency in Beijing transportation network.It proves a better implemental efficiency and applicability comparing with the best label setting algorithm-Dijkstra algorithm implemented with approximate buckets.As a result,it provides a good choice for network related analysis works and should be particularly useful to researchers and practitioners in operations research,transportation,and GIS.",
        "keywords": [
            "shortest path algorithms",
            "label algorithms",
            "complexity",
            "priority queue",
            "Pallottino algorithm"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "LERIS,Institute of Geographic Sciences and Natural Resources Research,CAS,Beijing "
            },
            {
                "name": "LU Feng",
                "org": "LERIS,Institute of Geographic Sciences and Natural Resources Research,CAS,Beijing "
            }
        ],
        "venue": "Journal of Image and Graphics",
        "year": 2006
    },
    "kfIRuWKi": {
        "id": "kfIRuWKi",
        "title": "Implementation and Evaluation of the Shortest Path Labeling Algorithms in Transportation Networks",
        "abstract": "Labeling algorithms have got broad applications for shortest path finding in transportation networks,among which various fine-tunned Dijkstra's algorithms well known as typical label setting algorithms have been selected by many GIS related software for network analysis.However,label correcting algorithms,the other group in label algorithms family,are rarely used yet in GIS network analysis.After detailed discussion on the structures of labeling algorithms,in this paper,the implementation,complexity and applicability of labeling setting and label correcting algorithms are analyzed.Then three best-known fastest label algorithms,i.e.,Dijkstra algorithm implemented with approximate buckets(DIKBA),Dijkstra's algorithm based on quad-heap priority queue(DIKQH) and Pallottino algorithm(TWO_-Q),were used to carry out practical evaluation on three real urban road networks.The results showed that for one-to-one shortest path calculation,DIKQH and DIKBA greatly outperformed than TWO-Q algorithm,and DIKQH exhibited the best running efficiency.For one-to-all shortest path calculation,however,TWO-Q algorithm runs a little faster than DIKQH and DIKBA on the selected real road networks.The author argued that more attention should be paid on TWO-Q algorithm for its efficiency and applicability.",
        "keywords": [
            "shortest path algorithms",
            "label algorithms",
            "complexity",
            "transportation networks"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "LERIS,Institute of Geographic Sciences and Natural Resources Research,CAS,Beijing "
            },
            {
                "name": "LU Feng",
                "org": "LERIS,Institute of Geographic Sciences and Natural Resources Research,CAS,Beijing "
            }
        ],
        "venue": "Journal of Image and Graphics",
        "year": 2005
    },
    "ZLuE1hDf": {
        "id": "ZLuE1hDf",
        "title": "Location Advantage and Accessibility Evaluation on Beijing-Tianjin-Hebei Metropolitan Area",
        "abstract": "Aimed at evaluating both of location advantage and transportation accessibility of Beijing-Tianjin-Hebei(Jing-Jin-Ji) metropolitan area,this paper from the perspective of spatial configuration adopted both the latest administrative division atlas and the fundamental geographic information database and statistics,with GIS spatial analysis methods as well,to conduct quantitative analysis and explicit descriptions on every present cities within the metropolitan area.The results showed that Tianjin,Beijing and Langfang possessed the obvious regional advantages,in which Tianjin occupied the highest level.Meanwhile Chengde and Zhangjiakou were comparatively backwards,mainly caused by the mountainous and hilly surroundings.Besides,it also showed a relatively balance to the overall performance of urban highway construction.Moreover,Qinhuangdao,Cangzhou and Shijiazhuang built close contact with nearby regions out of Jing-Jin-Ji metropolitan area,by their intensive transportation networks and their peripheral locations.",
        "keywords": [
            "location",
            "Beijing-Tianjin-Hebei metropolitan area",
            "travelling time-distance",
            "accessibility"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "LREIS,Institute of Geographical Sciences and Natural Resources Research,CAS,Beijing ,China"
            },
            {
                "name": "LU Feng",
                "org": "LREIS,Institute of Geographical Sciences and Natural Resources Research,CAS,Beijing ,China"
            }
        ],
        "venue": "Geography and Geo-Information Science",
        "year": 2008
    },
    "pe2RwsdH": {
        "id": "pe2RwsdH",
        "title": "Location Superiority and Accessibility Analysis on Wuhan Metropolitan Region",
        "abstract": "Wuhan \"1+8\" metropolitan region plays an extremely significant role in central China's construction as well as in the process of national economic development.From the perspective of spatial pattern,this paper adopts the latest administrative division data,fundamental geographic information database and statistic data to conduct quantitative analysis on both transportation accessibility and regional superiority of the present cities within Wuhan metropolitan region.The result shows an obvious regional advantage for the cities compared with other cities in the province.More specifically,Xiaogan occupies the highest indicators in location among all the 8 cities inside the region while Qianjiang,Xiantao and Tianmen comparatively rank behind.Each city is accessible within two hours from other cities in the region.Wuhan and Xiaogan have the highest increasing speed for traveling time distance,while Tianmen,Huangshi and Xianning behave weak and heed to improve their infrastructure construction.",
        "keywords": [
            "location",
            "Wuhan metropolitan region",
            "GIS",
            "accessibility"
        ],
        "authors": [
            {
                "name": "LU Feng",
                "org": "Institute of Geographic Sciences and Natural Resources Research,CAS,Beijing,"
            },
            {
                "name": "CHEN Jie",
                "org": "Institute of Geographic Sciences and Natural Resources Research,CAS,Beijing,"
            }
        ],
        "venue": "Progress in Geography",
        "year": 2008
    },
    "Bei9PzMk": {
        "id": "Bei9PzMk",
        "title": "Spatial Patterns of Domestic Passenger Transport and Competitive Situation for Chinese Civil Airlines",
        "abstract": "With statistical analysis and visualization, this research analyzes the characteristics of concerned domestic cities and airlines and competitive situation for the nine Chinese airline companies, based on latest Chinese civil aviation flight information for 60 delicately sampled Chinese cities. It is shown that the airlines of the three big aviation companies and Hainan airlines have formed multi-hub networks with high connectivity, while the other five companies only have single-hub or double-hub radial networks. The three big companies and Hainan airlines have apparent advantages of operational monopoly, and also intensive competition between them. Contrarily the other airline companies stand in apparent inferior competitive positions on the crucial airlines constituting Chinese civil aviation transport networks. The research is expected beneficial to airline and flight adjustment, code sharing and civil aviation policy enaction.",
        "keywords": [
            "spatial pattern",
            "air passenger transport",
            "competitive situation"
        ],
        "authors": [
            {
                "name": "LU Feng",
                "org": ""
            },
            {
                "name": "CHEN Jie",
                "org": ""
            },
            {
                "name": "ZHOU Chenghu",
                "org": ""
            }
        ],
        "venue": "Geo-information Science",
        "year": 2005
    },
    "69avhExL": {
        "id": "69avhExL",
        "title": "GIS-Based Analyzing Method for Spatial-Temporal Behavior Data",
        "abstract": "Time geography is a powerful conceptual framework for understanding constraints on human activity participation in space and time.Geo-visualization is an important approach to study spatial-temporal behavior.In this paper,the conceptual model of time geography is discussed first and data modeling of space-time path is built up.Next,a platform of mining temporal-spatial behavior patterns in ArcGIS environment is founded and 3D visualization of space-time path at individual level is realized.The capability of this prototype system has been demonstrated in an exploration of spatial-temporal behavior using data from activity diary survey collected in Beijing,2007,from which a group of residents living in Jiaodaokou community has been selected and applied.The system can allow users to retrieve and visualize spatial-temporal data according to various possible combinations of spatial,temporal,activity attribute and personal attribute criteria.The result shows that visualization is an effective method to identify spatial-temporal behavior patterns for it can integrate and analyze multi-dimensional information together.Discussions of the benefits and shortcomings associated with this method are provided,along with suggestions for future research.",
        "keywords": [
            "Geographic Information System(GIS)",
            "time geography",
            "space-time path",
            "3D visualization",
            "spatial-temporal behavior"
        ],
        "authors": [
            {
                "name": "ZHAO Ying",
                "org": "College of Urban and Environmental Science,Peking University,Beijing "
            },
            {
                "name": "CHAI Yan-wei",
                "org": "College of Urban and Environmental Science,Peking University,Beijing "
            },
            {
                "name": "CHEN Jie",
                "org": "Institute of Geographic Sciences and Natural Resources Research,Chinese Academy of Sciences,Beijing "
            },
            {
                "name": "MA Xiu-jun",
                "org": "School of Electronics and Computer Science,Peking University,Beijing ,China"
            }
        ],
        "venue": "Geography and Geo-Information Science",
        "year": 2009
    },
    "YIDdx6Wm": {
        "id": "YIDdx6Wm",
        "title": "Extracting traffic information from massive micro-blog messages",
        "abstract": "Micro-blog messages usually contain a great deal of traffic information such as traffic conditions,traffic events and traffic controls,which can be useed as a complement to conventional traffic information collection technologies like fixed sensors and floating cars.However,due to ambiguous narrating,uncertainty,and the unstructured characteristics of micro-blog messages,extracting traffic information from micro-blog messages is rather difficult.In this paper,we propose an approach for extracting traffic information from a large amount of micro-blog messages.First,we build a traffic information table by semantically extracting traffic related words from micro-blog messages and matching each word onto the corresponding road segment of the road networks.Then,according to the traffic information table,we evaluate the highest confidence level of traffic condition for each road segment by using a neural network based Fuzzy-C-Means(FCM) clustering method,to obtain the most confident road conditions.Experiments on Beijing road networks with a large number of Sina micro-blog messages verify the effectiveness of the presented approach.",
        "keywords": [
            "fuzzy clustering",
            "word segmentation",
            "clear degree",
            "traffic information",
            "degree of confidence",
            "micro-blog"
        ],
        "authors": [
            {
                "name": "Zhang Hengcai",
                "org": " State Key Lab of Resources and Environmental Information system,Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "Lu Feng",
                "org": " State Key Lab of Resources and Environmental Information system,Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "Chen Jie",
                "org": " State Key Lab of Resources and Environmental Information system,Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences,Beijing ,China"
            }
        ],
        "venue": "Journal of Image and Graphics",
        "year": 2013
    },
    "ZMcRtmhr": {
        "id": "ZMcRtmhr",
        "title": "Advance in Accessibility Evaluation Approaches and Applications",
        "abstract": "Accessibility is a research topic in the field of geography,civil engineering and transportation economics.Currently,a range of accessibility measurement approaches have been widely used in transportation network and urban development planning,transportation infrastructure effects evaluation on regional economy,location-allocation researches,landscape planning,social culture researches,to name a few.With rapid increasing of application demands and unceasing development of technology researches,accessibility measurement approaches also develop swiftly and the methodology is being formed.Based on a comprehensive exposition of accessibility concept,this paper systematically discusses the state-of-arts of accessibility measurement approaches,carries out a classification of these approaches from the perspective of network characteristics,and comparably elaborates and evaluates these approaches according to their influencing factors.Then application of various approaches are discoursed and analyzed in detail,consistent with different application areas.Finally the research priorities of accessibility research are thoroughly discussed.",
        "keywords": [
            "state-of-arts",
            "evaluation",
            "measurement",
            "accessibility"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "LREIS,Institute of Geographic Sciences and Natural Resources Research,CAS,Beijing ,China"
            },
            {
                "name": "LU Feng",
                "org": "LREIS,Institute of Geographic Sciences and Natural Resources Research,CAS,Beijing ,China"
            },
            {
                "name": "CHENG Changxiu",
                "org": "LREIS,Institute of Geographic Sciences and Natural Resources Research,CAS,Beijing ,China"
            }
        ],
        "venue": "Progress in Geography",
        "year": 2007
    },
    "Ora6zGAQ": {
        "id": "Ora6zGAQ",
        "title": "Advance in Moving Object Data Modeling under Geographic Network Environment",
        "abstract": "In recent years,along with the rapid development of location technologies such as GPS,RFID and wireless sensor networks as well as the widespread use of location-aware devices such as mobile phones and GPS receivers,large amounts of trajectories of moving objects can be easily acquired.By using moving objects databases,massive trajectories of moving objects can be manipulated and handled for various applications,which makes the study of moving objects databases more and more important.Among the most recent researches,the study space where moving objects travel can be mainly divided into two types,the Euclidean space and the geographic road networks.In Euclidean space,moving objects can move freely.However,under geographic network environment,moving objects are limited to geographic networks and must follow the road regulation.For the latter research branch is much more practical than the former one,this paper concerns the latter branch and focuses on modeling moving objects in geographic networks,which is the foundation of the study of moving objects databases.It has been a hot research topic in the field of moving objects database management and also provides key technology for many other areas such as transportation,location-based services,urban mobility and social computing.Although it is of great theoretical significance and application value,modeling moving object in geographic networks challenges the research community a lot due to network constraints.In this paper,firstly,most existent geographic network-constrained moving object data models over recent decades has been systematically reviewed and classified.The related literatures show that most geographic network-constrained models can be divided into four categories including edge-based network-constrained model,route-based network-constrained model,partition-based network-constrained model and spatial-temporal network-constrained model.Then model characteristics,advantages as well as limitations have been elaborately analyzed,based on which,finally some crucial points on modeling moving objects in geographic networks has been proposed and discussed.",
        "keywords": [
            "spatial network",
            "trajectories",
            "moving objects databases",
            "data model"
        ],
        "authors": [
            {
                "name": "ZHANG Hengcai",
                "org": "State Key Laboratory of Resources and Environmental Information system,Institute of Geographic Sciences and Natural Resources Research,CAS,Beijing ,China"
            },
            {
                "name": "LU Feng",
                "org": "State Key Laboratory of Resources and Environmental Information system,Institute of Geographic Sciences and Natural Resources Research,CAS,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "State Key Laboratory of Resources and Environmental Information system,Institute of Geographic Sciences and Natural Resources Research,CAS,Beijing ,China"
            }
        ],
        "venue": "Journal of Geo-Information Science",
        "year": 2013
    },
    "h9zwFJGe": {
        "id": "h9zwFJGe",
        "title": "Study on Technical Thinking of Mineral Resources Management Information System (Mineral Management with One-Chart) of Hubei Province",
        "abstract": "To improve the level of the informatization of mineral resources management,the Department of Land and Resource of Hubei Province has started the construction of mineral resources management information system(Mineral Management with One-Chart) based on the existing achievements from the daily work.The system would use GIS,DW and other information technology,integrate all kinds of mineral resources management database,emphasize the mineral right,meet the work needs such as approbation,supervision,data browsing and so on,and realize the dynamic sharing and application of province,city and county's data of mineral resources management.Based on the general idea,the paper has studied the technical thinking of mineral resources management information system,which would lay the foundation of the follow-up development and application.",
        "keywords": [
            "mineral management with One-Chart",
            "mineral resources management",
            "informatization"
        ],
        "authors": [
            {
                "name": "YANG Wensen",
                "org": "School of Geodesy and Geomatics,Wuhan University,Wuhan,Hubei ;Hubei Land Planning and Surveying Institute,Wuhan,Hubei "
            },
            {
                "name": "CHEN Jie",
                "org": "Department of Land and Resource of Hubei Province,Wuhan,Hubei "
            },
            {
                "name": "LU Shidong",
                "org": "Hubei Land Planning and Surveying Institute,Wuhan,Hubei "
            },
            {
                "name": "ZHANG Ling",
                "org": "Hubei Geological Exploration Institute of CHEM,Jingzhou,Hubei "
            }
        ],
        "venue": "Resources Environment & Engineering",
        "year": 2012
    },
    "23YjX5VT": {
        "id": "23YjX5VT",
        "title": "A GIS-based Time-geographic Approach of Studying Individual Activities and Interactions in a Hybrid Physicalvirtual Space",
        "abstract": "Modern information and communication technologies (ICT) are changing human activity and travel patterns that could have significant implications to our everyday lives and the human organization of space.Time geography,which examines human activities under various constraints in a space-time context,provides a useful framework to analyze the complex spatio-temporal relationships among activities and interactions taking place in both physical and virtual spaces.However,virtual activities and interactions conducted via ICT have characteristics that cannot be properly represented and analyzed under the classical time-geographic framework.This paper extends classical time-geographic concepts to accommodate the needs of representing and analyzing all activities and interactions in a hybrid physical-virtual space.In addition,this paper presents a space-time geographic information system (GIS) design that is capable of organizing complex activity and interaction data as spatio-temporal processes in an integrated space-time environment.This space-time GIS design offers a useful analytical environment for researchers to study increasingly dynamic human activity and travel patterns in today's society and their implications toward changing travel demand patterns from both spatial and temporal perspectives.",
        "keywords": [
            "Time Geography Hybrid",
            "Physical-virtual Space",
            "Space-time GIS",
            "Activity and Travel Pattern"
        ],
        "authors": [
            {
                "name": "\u8427\u4e16(\u738b\u4ed1)",
                "org": ""
            },
            {
                "name": "\u4e8e\u6d2a\u6ce2",
                "org": ""
            },
            {
                "name": "\u9648\u6d01",
                "org": ""
            }
        ],
        "venue": "Urban Planning International",
        "year": 2010
    },
    "FM0qN2c4": {
        "id": "FM0qN2c4",
        "title": "Evaluating the Accessibility about Beijing\u2032s Subways in 2008 Based on Spatial Syntax",
        "abstract": "Accessibility is an important factor in urban planning,real estate development and traffic management.According to the characteristics of Beijing\u2032s subways that the passengers usually cares about the transfer times rather than traffic distance,this paper used the average depth value of spatial syntax to quantitatively evaluate the accessibility of Beijing\u2032s subways in 2008.The evaluation results show that 1) the evaluation method based on spatial syntax is reasonable to measure the accessibility of Beijing\u2032s subways;2) the evaluation results about each subwayline are more macroscopical and coarse,and the evolution results about starting/terminal station and transfer station are more microscopical and elaborate;3) the plan about Beijing\u2032s subways in 2008 takes into account the bloomed traffic requirement on some keys districts,for example,Zhongguancun district,Yayuncun and Aoyuncun district,Xidan district and Dongdan district;and 4) compared with the other subway lines in inner city, the accessibilities of No.8 and No.9 lines are worse for the accessibilitise of the subways are closer to suburbs,therefore rational running plans should be made according to the OD flow,for example,to adjust the number of carriage,number of runs.",
        "keywords": [
            "Beijing\u2032s subway",
            "spatial syntax",
            "accessibility"
        ],
        "authors": [
            {
                "name": "CHENG Changxiu",
                "org": "Institute of Geographic Sciences and Natural Resources Research,CAS,Beijing ,China"
            },
            {
                "name": "ZHANG Wenchang",
                "org": "Institute of Geographic Sciences and Natural Resources Research,CAS,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Institute of Geographic Sciences and Natural Resources Research,CAS,Beijing ,China"
            },
            {
                "name": "CAI Jun",
                "org": "Institute of Geographic Sciences and Natural Resources Research,CAS,Beijing ,China"
            }
        ],
        "venue": "Geo-Information Science",
        "year": 2007
    },
    "UKCbNwiH": {
        "id": "UKCbNwiH",
        "title": "Sign-consensus of multi-agent systems over fast switching signed graphs.",
        "abstract": "This paper studies sign-consensus of linear multi-agent systems, i.e., states of all agents will eventually have the same sign, but may with different magnitudes. The interactions between agents consist of both collaboration and competition, which is modeled by a signed directed graph. Moreover, the graph is allowed to be structurally unbalanced and time varying. To achieve sign-consensus, condition of the graph topology is obtained, and distributed control law is proposed and analyzed.",
        "keywords": "",
        "authors": [
            {
                "name": "Ye Jiang",
                "org": "School of Electrical Engineering, Southwest Jiaotong University, Chengdu, Sichuan, 610031, P. R. China"
            },
            {
                "name": "Hongwei Zhang",
                "org": "School of Electrical Engineering, Southwest Jiaotong University, Chengdu, Sichuan, 610031, P. R. China"
            },
            {
                "name": "He Cai",
                "org": "School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Hong Kong"
            }
        ],
        "venue": "CDC",
        "year": 2017
    },
    "Cu48MtbW": {
        "id": "Cu48MtbW",
        "title": "H/sub /spl infin// identification of multivariable systems by tangential interpolation methods",
        "abstract": "The purpose of this paper is to present an extension to some of the current work on worst-case identification problems to multivariable systems. We consider an H/sub /spl infin//-identification problem for a class of linear shift invariant multi-input/multi-output systems. Our main results are an interpolatory algorithm and a number of bounds on the identification error. This algorithm operates on available input and output data in the time domain and is constructed by solving an extended matrix tangential Caratheodory-Fejer problem. Similar to its counterpart for scalar systems, this interpolatory algorithm possesses certain desirable optimality properties and can be obtained via standard convex programming methods.",
        "keywords": [
            "Interpolation",
            "MIMO",
            "Uncertainty",
            "Upper bound",
            "Space technology",
            "Transfer functions",
            "Stability",
            "Noise level",
            "Signal processing",
            "Robust control"
        ],
        "authors": [
            {
                "name": "jie chen",
                "org": "university of california"
            },
            {
                "name": "jay a farrell",
                "org": ""
            },
            {
                "name": "c n nett",
                "org": ""
            },
            {
                "name": "keliang zhou",
                "org": ""
            },
            {
                "name": "",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Automatic Control",
        "year": 1994
    },
    "yssqQZKL": {
        "id": "yssqQZKL",
        "title": "Multivariable gain-phase and sensitivity integrals",
        "abstract": "In this paper we present several extensions of the classical Bode integral relations to multivariable systems. Our main contribution includes an extended gain-phase integral formula and an extended sensitivity integral relation. These results are useful for analyzing certain fundamental design limitations that arise in linear multivariable feedback systems. In particular, they provide important insights into feedback properties which are unique to multivariable systems and which cannot be inferred from the scalar integral relations. Both results show that design limitations in multivariable systems depend strongly upon certain directionality properties",
        "keywords": [
            "control system synthesis",
            "feedback",
            "integral equations",
            "linear systems",
            "multivariable control systems",
            "sensitivity analysis",
            "stability",
            "bode integral",
            "design limitations",
            "directionality",
            "gain-phase integral",
            "linear multivariable feedback systems",
            "sensitivity integrals",
            "mimo",
            "aerospace engineering",
            "transfer functions",
            "image sensors",
            "uncertainty",
            "feedback system"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Sch. of Aerosp. Eng., Georgia Inst. of Technol., Atlanta, GA, USA|c|"
            }
        ],
        "venue": "San Antonio, TX",
        "year": 1993
    },
    "BYasMisg": {
        "id": "BYasMisg",
        "title": "Heavy Ion Irradiation of Zirconate Pyrochlores",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "j lian",
                "org": "university of michigan"
            },
            {
                "name": "l m wang",
                "org": "university of michigan"
            },
            {
                "name": "jiqiu chen",
                "org": "university of michigan"
            },
            {
                "name": "rodney c ewing",
                "org": "university of michigan"
            },
            {
                "name": "k v g kutty",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2002
    },
    "1b7todgr": {
        "id": "1b7todgr",
        "title": "Robust consensus of discrete-time linear agents over deterministic uncertain channels.",
        "abstract": "In this paper, we study the robust consensus problem for a group of linear discrete-time agents to coordinate over an uncertain communication network, which is to achieve consensus against transmission errors and noises. We model the network by communication links subject to deterministic uncertainties, which can be either an additive perturbation described by some unknown transfer function or a norm bounded uncertainty. We show that the robust consensus problem with undirected communication topologies is equivalent to the simultaneous control problem for a set of low-dimensional subsystems. We derive a necessary condition for the existence of a protocol achieving robust consensus. That is, the upper bound of the uncertainties is less than the inverse of the Mahler measure of the agents. Sufficient conditions in terms of linear matrix inequalities are further presented to design the robust consensus protocols.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhongkui Li",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "ICCA",
        "year": 2016
    },
    "UqRHRmQE": {
        "id": "UqRHRmQE",
        "title": "Stability and instability intervals of polynomially dependent systems: An matrix pencil analysis.",
        "abstract": "In this paper we present a stability analysis approach for polynomially-dependent one-parameter systems. The approach, which appears to be conceptually appealing and computationally efficient and is referred to as an eigenvalue perturbation approach, seeks to characterize the analytical and asymptotic properties of eigenvalues of matrix-valued functions or operators. The essential problem dwells on the asymptotic behavior of the critical eigenvalues on the imaginary axis, that is, on how the imaginary eigenvalues may vary with respect to the varying parameter. This behavior determines whether the imaginary eigenvalues cross from one half plane into another, and hence plays a critical role in determining the stability of such systems. Our results reveal that the eigenvalue asymptotic behavior can be characterized by solving a simple generalized eigenvalue problem, leading to numerically efficient stability conditions.",
        "keywords": "",
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, China"
            },
            {
                "name": "Peilin Fu",
                "org": "Department of Applied Engineering, National University, San Diego, CA 92123 USA"
            },
            {
                "name": "C\u00e9sar-Fernando M\u00e9ndez-Barrios",
                "org": "Faculty of Engineering, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Av. Dr. Manuel Nava No.8, 78290, S.L.P. Mexico"
            },
            {
                "name": "Silviu-Iulian Niculescu",
                "org": "Laboratoire des Signaux et Syst\u00e8mes (L2S, UMR CNRS 8506), CNRS-Sup\u00e9lec, 3, rue Joliot Curie, 91192, Gifsur-Yvette, France"
            },
            {
                "name": "Hongwei Zhang",
                "org": "School of Electrical Engineering, Southwest Jiaotong University, Chengdu, China"
            }
        ],
        "venue": "ACC",
        "year": 2017
    },
    "HNIJl6tu": {
        "id": "HNIJl6tu",
        "title": "Robust stability of quasipolynomials: frequency-sweeping conditions",
        "abstract": "",
        "keywords": [
            "robust control",
            "frequency domain analysis",
            "polynomials"
        ],
        "authors": [
            {
                "name": "jie chen",
                "org": "university of california"
            },
            {
                "name": "s i niculescu",
                "org": ""
            }
        ],
        "venue": "conference on decision and control",
        "year": 2003
    },
    "KU2PYSKq": {
        "id": "KU2PYSKq",
        "title": "On robustness analysis with non-diagonally structured uncertainty",
        "abstract": "The authors study the structured singular value for a class of robustness analysis problems in which the uncertainty is allowed to be non-diagonally structured, and the norm of each block is individually considered. The results extend previous work conducted for problems where each uncertainty block is assumed to be a scalar. Computations of this generalization notion via both the similarity and nonsimilarity scaling methods are investigated. It is shown in particular that under certain circumstances the structured singular value defined here coincides with a vector-induced norm",
        "keywords": [
            "matrix algebra",
            "stability",
            "nondiagonally structured uncertainty",
            "robustness analysis",
            "scalar uncertainty",
            "vector-induced norm",
            "systems engineering",
            "robustness",
            "singularity mathematics",
            "feedback",
            "scalars",
            "constraint optimization",
            "upper bound",
            "transfer functions",
            "feedback control",
            "systems analysis",
            "uncertainty"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Georgia Inst. of Technol., Atlanta, GA, USA|c|"
            },
            {
                "name": "Fan, M.K.H.",
                "org": ""
            },
            {
                "name": "Nett, C.N.",
                "org": ""
            }
        ],
        "venue": "Brighton",
        "year": 1991
    },
    "sHLX0mvF": {
        "id": "sHLX0mvF",
        "title": "Worst case system identification in H\u221e: validation of a priori information, essentially optimal algorithms, and error bounds",
        "abstract": "Resolves several important open issues pertaining to a worst-case control-oriented system identification problem known as identification in H\u221e. First, a method is presented for developing confidence that certain a priori information available for identification is not invalid. This method requires the solution of a certain nondifferentiable convex program. Second, an essentially optimal identification algorithm is constructed. This algorithm is (worst-case strongly) optimal to within a factor of two. Finally, new upper and lower bounds on the optimal identification error are derived and used to estimate the identification error associated with the given algorithm. Interestingly, the development of each of these results draws heavily upon the classical Nevanlinna-Pick interpolation theory. As such, the authors' results establish a clear link between the areas of system identification and optimal interpolation theory. Both the formulation and techniques in this paper are applicable to problems where the frequency data available for identification may essentially be arbitrarily distributed",
        "keywords": [
            "identification",
            "interpolation",
            "H\u221e identification",
            "Nevanlinna-Pick interpolation theory",
            "confidence",
            "error bounds",
            "lower bounds",
            "nondifferentiable convex program",
            "optimal algorithms",
            "optimal identification error",
            "upper bounds",
            "worst case system identification"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Coll. of Eng., California Univ., Riverside, CA, USA|c|"
            },
            {
                "name": "Nett, C.N.",
                "org": ""
            },
            {
                "name": "michael k h fan",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Automatic Control",
        "year": 1995
    },
    "P0ikYInr": {
        "id": "P0ikYInr",
        "title": "A canonical structure for constrained optimal control problems",
        "abstract": "",
        "keywords": [
            "hydrogen",
            "stability",
            "optimal control",
            "robust control",
            "constrained optimization",
            "data mining",
            "control systems",
            "steady state",
            "transfer functions",
            "gain",
            "adaptive control"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Guoxiang Gu",
                "org": ""
            },
            {
                "name": "Carl N. Nett",
                "org": ""
            },
            {
                "name": "Dapeng Xiong",
                "org": ""
            }
        ],
        "venue": "International Journal of Robust and Nonlinear Control",
        "year": 1996
    },
    "lrnOxnkd": {
        "id": "lrnOxnkd",
        "title": "Fundamental limitations and intrinsic limits of feedback: An overview in an information age",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Song Fang",
                "org": ""
            },
            {
                "name": "Hideaki Ishii",
                "org": ""
            }
        ],
        "venue": "Annual Reviews in Control",
        "year": 2019
    },
    "CuKKENhZ": {
        "id": "CuKKENhZ",
        "title": "On sufficient conditions for stability independent of delay",
        "abstract": "",
        "keywords": [
            "polynomials",
            "linear time invariant",
            "difference equations",
            "linear systems",
            "testing",
            "asymptotic stability"
        ],
        "authors": [
            {
                "name": "jie chen",
                "org": "university of california"
            },
            {
                "name": "demin xu",
                "org": ""
            },
            {
                "name": "bahram shafai",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Automatic Control",
        "year": 1995
    },
    "YJ9hiVgt": {
        "id": "YJ9hiVgt",
        "title": "Sign-consensus of linear multi-agent systems over signed graphs using a fully distributed protocol.",
        "abstract": "This paper aims at solving the sign-consensus problem of linear multi-agents system, i.e., the signs of all agentsu0027 states achieve consensus. The communication network is modeled by a signed directed graph, where both cooperative and competitive interactions coexist among the agents. Each individual agent is assumed to access only the local information, and a fully distributed control protocol is proposed. Using this control protocol, we find that sign consensus can be achieved without requiring the graph to have an eventually positive adjacency matrix.",
        "keywords": "",
        "authors": [
            {
                "name": "Ye Jiang",
                "org": "School of Electrical Engineering, Southwest Jiaotong University, Chengdu, Sichuan, 610031, China"
            },
            {
                "name": "Hongwei Zhang",
                "org": "School of Electrical Engineering, Southwest Jiaotong University, Chengdu, Sichuan, 610031, China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Hong Kong"
            }
        ],
        "venue": "CDC",
        "year": 2016
    },
    "IPygMDBc": {
        "id": "IPygMDBc",
        "title": "Trade-offs in information-limited feedback systems: MIMO Bode-type integrals and power allocation.",
        "abstract": "In this paper we study Bode-type integrals for multivariate networked feedback systems in which the uplink and downlink noisy channels are present simultaneously. The integrals, which are obtained via an information-theoretic approach, characterize explicitly the fundamental performance trade-offs of disturbance attenuation in networked control systems. Two information-theoretic measures, termed negentropy rate and channel blurredness respectively, are proposed to quantify the effect of the multivariate disturbance and communication channel constraints on the Bode-type integrals. In particular, when it comes to parallel additive white Gaussian noise channels, channel blurredness leads to a totally new \u2018fire-quenching\u2019 power allocation policy in contrast to the conventional \u2018water-filling\u2019 solution.",
        "keywords": [],
        "authors": [
            {
                "name": "Song Fang",
                "org": ""
            },
            {
                "name": "Hideaki Ishii",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "CDC",
        "year": 2015
    },
    "R7z6z2hl": {
        "id": "R7z6z2hl",
        "title": "Small-gain stability conditions for linear systems with time-varying delays",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Jing Zhu",
                "org": ""
            },
            {
                "name": "Tian Qi",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Systems & Control Letters",
        "year": 2015
    },
    "CeTgRdLu": {
        "id": "CeTgRdLu",
        "title": "Kalman Filtering over Networks in Presence of Multi-Channel Correlated Packet Drops.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jianqi Chen",
                "org": "City University of Hong Kong,Department of Electronic Engineering,,Kowloon,SAR,China"
            },
            {
                "name": "Jie Chen",
                "org": "City University of Hong Kong,Department of Electronic Engineering,,Kowloon,SAR,China"
            }
        ],
        "venue": "ICCA",
        "year": 2019
    },
    "nQAgHIj8": {
        "id": "nQAgHIj8",
        "title": "When will zeros of time-delay systems cross imaginary axis?",
        "abstract": "A time-delay system may or may not be stable for different periods of delay. When will then a delay system be stable or unstable, and for what ranges of delay? This paper attempts to answer these questions. We show that by finding a set of critical delay values, for which the system's characteristic quasipolynomial has zeros on the imaginary axis, it is possible to determine its stability in the full range of the delay parameter by characterizing the analytical behaviors of the zeros. This characterization is facilitated by an operator perturbation approach, which is both conceptually attractive and computationally efficient. The entire procedure, which first identifies the critical zeros on the imaginary axis and next determines whether the zeros cross the imaginary axis, requires only solving a generalized eigenvalue problem.",
        "keywords": [
            "delays",
            "eigenvalues and eigenfunctions",
            "linear systems",
            "perturbation techniques",
            "polynomials",
            "stability",
            "eigenvalue problem",
            "imaginary axis",
            "linear time-delay system",
            "operator perturbation",
            "system characteristic quasipolynomial",
            "system stability",
            "time-delay",
            "asymptotic behavior",
            "asymptotic stability",
            "critical zeros",
            "matrix pencil"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Dept. of Electr. Eng., Univ. of California, Riverside, Riverside, CA, USA|c|"
            },
            {
                "name": "Peilin Fu",
                "org": ""
            },
            {
                "name": "Niculescu, S.-I.",
                "org": ""
            }
        ],
        "venue": "Control Conference",
        "year": 2007
    },
    "ZQd1ck45": {
        "id": "ZQd1ck45",
        "title": "Fundamental performance limitations in tracking sinusoidal signals",
        "abstract": "This paper attempts to give a thorough treatment of the performance limitation of a linear time invariant multivariable system in tracking a reference signal which is a linear combination of a step signal and several sinusoids with different frequencies. The tracking performance is measured by an integral square error between the output of the plant and the reference signal. Our purpose is to find the fundamental limit for the attainable tracking performance, under any control structure and parameters, in terms of the characteristics and structural parameters of the given plant, as well as those of the reference signal under consideration. It is shown that this fundamental limit depends on the interaction between the reference signal and the nonminimum phase zeros of the plant and their frequency-dependent directional information.",
        "keywords": [
            "Frequency",
            "Tracking loops",
            "Error correction",
            "MIMO",
            "Structural engineering",
            "Optimal control",
            "Feedback control",
            "Signal design",
            "Control systems",
            "Closed loop systems"
        ],
        "authors": [
            {
                "name": "Weizhou Su",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "Li Qiu",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Automatic Control",
        "year": 2003
    },
    "xaW9QANa": {
        "id": "xaW9QANa",
        "title": "On computing the maximal delay intervals for stability of linear delay systems",
        "abstract": "This paper is concerned with stability properties of linear time-invariant delay systems. The author considers both retarded and neutral delay systems expressed in state space form. The author's main goal is to provide a method for computing the maximal delay intervals for which the systems under consideration maintain stability. The author's results show that this can be accomplished by computing the generalized eigenvalues of certain frequency-dependent matrices. Based on these results, the author also states an improved necessary and sufficient condition concerning stability independent of delay for each of the retarded and neutral systems. The author's results appear to be simpler and may be implemented more easily than those developed elsewhere.",
        "keywords": [
            "Stability",
            "Delay systems",
            "Eigenvalues and eigenfunctions",
            "Frequency",
            "Differential equations",
            "Sufficient conditions",
            "System testing",
            "Polynomials",
            "Transforms"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Brown University, RI"
            }
        ],
        "venue": "IEEE Transactions on Automatic Control",
        "year": 1994
    },
    "pF8eKD5r": {
        "id": "pF8eKD5r",
        "title": "The Caratheodory-Fejer problem and H/sub \u221e//l/sub 1/ identification: a time domain approach",
        "abstract": "",
        "keywords": [
            "lower bound",
            "interpolation",
            "time domain",
            "time series",
            "convex programming",
            "transfer functions",
            "design methodology",
            "robust control",
            "upper bound",
            "stability",
            "identification"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Brown University, RI"
            },
            {
                "name": "C. N. Nett",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Automatic Control",
        "year": 1995
    },
    "EdIi2IYE": {
        "id": "EdIi2IYE",
        "title": "Sensitivity Integral Relations and Design Tradeoffs in Linear Multivariable Feedback Systems",
        "abstract": "The purpose of this paper is to develop integral relations regarding the singular values of the sensitivity function in linear multivariable feedback systems. The main utility of these integral relations is that they can be used to quantify the fundamental limitations which arise due to system characteristics such as open loop unstable poles and nonminimum phase zeros, and those due to such fundamental design requirements as stability and bandwidth constraints. We present extensions to both the classical Bode sensitivity integral relation and its extension, and the classical Poisson integral formula. These extended integral relations exhibit important insights toward the tradeoffs that must be performed between the sensitivity reduction and increase due to the aforementioned system characteristics and design constraints. Most importantly, these integral relations display new phenomena concerning the design limitations in multivariable systems which have no analog in single-input single-output systems. The unique phenomena in multivariable systems are that the tradeoffs and limitations on the sensitivity design are related to the directionality properties of the sensitivity function, and to those of open loop unstable poles and nonminimum phase zeros, in addition to factors present in single-input single-output systems.",
        "keywords": [
            "aerospace engineering",
            "stability analysis",
            "transfer functions",
            "bandwidth",
            "feedback loop",
            "frequency",
            "poles and zeros",
            "sensitivity",
            "mimo"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Schools of Electrical and Aerospace Engineering, Georgia Tech, Atlanta, GA 30332. Tel: (404)853-0177 Email: chen@licchus3.gatech.edu|c|"
            }
        ],
        "venue": "San Francisco, CA, USA",
        "year": 1993
    },
    "kspdUt2Z": {
        "id": "kspdUt2Z",
        "title": "Fully Distributed Adaptive Output Feedback Protocols for Linear Multi-Agent Systems with Directed Graphs: A Sequential Observer Design Approach",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yuezu lv",
                "org": ""
            },
            {
                "name": "zhongkui li",
                "org": ""
            },
            {
                "name": "zhisheng duan",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            }
        ],
        "venue": "CoRR",
        "year": 2015
    },
    "7BCiB2bk": {
        "id": "7BCiB2bk",
        "title": "Bounds on Delay Margin for Consensus of Second-Order Multi-Agent Systems.",
        "abstract": "This paper studies the delay margin and its bounds for second-order multi-agent systems to achieve robust consensus with respect to uncertain delays varying within a range. The issue under investigation dwells on the question: What is the largest delay range within which a distributed control protocol is able to achieve and maintain the consensus? We consider several second-order agents with different poles distributing on the complex plane communicating over an undirected network topology, and derive bounds on the delay margin. The results show that for a strictly unstable second-order multi-agent system, its consensuability robustness depends on the pole locations of the agents, as well as on the eigen-ratio of the network graph.",
        "keywords": "",
        "authors": [
            {
                "name": "Dan Ma",
                "org": ""
            },
            {
                "name": "Rui Tian",
                "org": ""
            },
            {
                "name": "Adil Zulfiqar",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Tianyou Chai",
                "org": ""
            }
        ],
        "venue": "CDC",
        "year": 2018
    },
    "hEbGdaD4": {
        "id": "hEbGdaD4",
        "title": "Brief paper: Probabilistic bounds for l 1 uncertainty model validation",
        "abstract": "",
        "keywords": [
            "gaussian distribution"
        ],
        "authors": [
            {
                "name": "wenguo liu",
                "org": "university of california riverside"
            },
            {
                "name": "jie chen",
                "org": "university of california riverside"
            },
            {
                "name": "h elsherief",
                "org": ""
            }
        ],
        "venue": "Automatica",
        "year": 2007
    },
    "AG40BEsG": {
        "id": "AG40BEsG",
        "title": "Control Over Additive White Gaussian Noise Channels: Bode-Type Integrals, Channel Blurredness, Negentropy Rate, and Beyond",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "song fang",
                "org": ""
            },
            {
                "name": "hideaki ishii",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "vgRf9Tsd": {
        "id": "vgRf9Tsd",
        "title": "Balanced truncation with relative/multiplicative error bounds in L/sub /spl infin// norm",
        "abstract": "",
        "keywords": [
            "controllability",
            "observability"
        ],
        "authors": [
            {
                "name": "jie chen",
                "org": "university of california"
            },
            {
                "name": "guoxiang gu",
                "org": ""
            },
            {
                "name": "kemin zhou",
                "org": ""
            }
        ],
        "venue": "conference on decision and control",
        "year": 1995
    },
    "rinb4fij": {
        "id": "rinb4fij",
        "title": "Design constraints and limits of networked feedback in disturbance attenuation: An information-theoretic analysis.",
        "abstract": "In this paper we investigate the intrinsic design constraints and performance limits of networked control systems. We propose new information measures and correspondingly, develop an information-theoretic paradigm for analyzing the performance trade-offs and limits in disturbance attenuation over information-constrained networked feedback, which is enabled by a cohesive development of new information measures, Bode-type integral inequalities, and performance bounds. The integrals and bounds incorporate the information measures and serve to quantify the trade-offs and limits in disturbance attenuation for broad classes of networked feedback systems consisting of linear time-invariant plants and causal, possibly nonlinear, time-varying stabilizing controllers communicating over general noisy channels with causal encoders and decoders. The notion of negentropy rate is introduced to address general, non-Gaussian disturbances. The channel blurredness, a newly proposed information measure for the quality of communication channels, is used to characterize the effect of communication channel noises on the integrals and henceforth the trade-offs in disturbance attenuation. Bounds on the power gain, a novel disturbance attenuation measure tailored for performance analysis of networked control systems, provide the fundamental limits of disturbance attenuation achievable by networked feedback.",
        "keywords": [
            "Networked control systems",
            "Performance limitation",
            "Information-theoretic analysis",
            "Entropy"
        ],
        "authors": [
            {
                "name": "Song Fang",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Hong Kong, China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Hong Kong, China"
            },
            {
                "name": "Hideaki Ishii",
                "org": "Department of Computer Science, Tokyo Institute of Technology, Yokohama, Japan"
            }
        ],
        "venue": "Automatica",
        "year": 2017
    },
    "vAHFPVNU": {
        "id": "vAHFPVNU",
        "title": "Moving horizon estimation for multi-rate systems.",
        "abstract": "This paper investigates the moving horizon estimation (MHE) problem for process systems with multi-rate sampling and bounded noises, where the sampling rates of the sensors are not identical. In the sense of the multi-rate systems, some sensors may have no measurements at certain sampling times, which can be regarded as measurement missing and may significantly degrade the estimation performance. The main purpose of this paper is to design an estimator by using a multi-rate MHE (MMHE) strategy. A binary switching sequence is introduced to model the multi-rate sampling, and the missing sample of the slow measurement is compensated by a prediction value. By choosing a cost function, the optimal estimator is obtained by solving a regularized least-squares problem. The stability analysis for the optimal estimator is also presented. Finally, a continuous stirred tank reactor (CSTR) example is given to demonstrate the effectiveness of the proposed method.",
        "keywords": [],
        "authors": [
            {
                "name": "Andong Liu",
                "org": ""
            },
            {
                "name": "Wen-an Zhang",
                "org": ""
            },
            {
                "name": "Li Yu",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "CDC",
        "year": 2015
    },
    "goosw628": {
        "id": "goosw628",
        "title": "Robustness Properties of Feedback Systems with Multiple Sources of Uncertainty",
        "abstract": "",
        "keywords": [
            "probability density function",
            "uncertainty",
            "stability analysis",
            "feedback",
            "gain",
            "frequency",
            "data mining",
            "robustness"
        ],
        "authors": [
            {
                "name": "jie chen",
                "org": "university of michigan"
            },
            {
                "name": "james s freudenberg",
                "org": "university of michigan"
            }
        ],
        "venue": "american control conference",
        "year": 1990
    },
    "1C6nv8yJ": {
        "id": "1C6nv8yJ",
        "title": "Best achievable tracking performance in sampled-data control systems",
        "abstract": "",
        "keywords": [
            "linear systems",
            "control systems",
            "sampling methods",
            "uncertainty",
            "stability",
            "error correction",
            "open loop systems"
        ],
        "authors": [
            {
                "name": "jie chen",
                "org": "university of california"
            },
            {
                "name": "satoshi hara",
                "org": ""
            },
            {
                "name": "li qiu",
                "org": ""
            },
            {
                "name": "richard h middleton",
                "org": ""
            }
        ],
        "venue": "international conference on control and automation",
        "year": 2002
    },
    "msG99BX2": {
        "id": "msG99BX2",
        "title": "Robust stability of quasipolynomials: vertex-type tests and extensions",
        "abstract": "We study the robust stability of uncertain quasipolynomials, whose coefficients may vary in a certain prescribed range. We consider specifically the so-called interval and diamond quasipolynomials, and our goal is to develop vertex- and edge type-conditions for these quasipolynomial families to be robustly stable independent of delay. Moreover, we also present a number of extensions to more general uncertain quasipolynomials, including both frequency-sweeping and vertex/edge type results.",
        "keywords": [
            "delays",
            "stability",
            "time-varying systems",
            "edge type-conditions",
            "frequency-sweeping",
            "quasipolynomials robust stability",
            "vertex-type tests",
            "frequency domain analysis",
            "stability analysis",
            "polynomials",
            "petroleum",
            "testing",
            "robustness"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Dept. of Electr. Eng., California Univ., Riverside, CA, USA|c|"
            },
            {
                "name": "Niculescu, S.-I.",
                "org": ""
            }
        ],
        "venue": "American Control Conference, 2004. Proceedings of the 2004",
        "year": 2004
    },
    "rGNmLyi5": {
        "id": "rGNmLyi5",
        "title": "Computation of L 2 [0, h] induced norms",
        "abstract": "",
        "keywords": [
            "multidimensional systems",
            "control systems",
            "differential equations",
            "linear systems",
            "sampled data systems",
            "dentistry",
            "testing"
        ],
        "authors": [
            {
                "name": "guoxiang gu",
                "org": "louisiana state university"
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "onur toker",
                "org": ""
            }
        ],
        "venue": "conference on decision and control",
        "year": 1996
    },
    "NDYWHo9S": {
        "id": "NDYWHo9S",
        "title": "Distributed adaptive output feedback consensus protocols for linear systems on directed graphs with a leader of bounded input.",
        "abstract": "This paper studies output feedback consensus protocol design problems for linear multi-agent systems with directed graphs containing a leader whose control input is nonzero and bounded. We present novel distributed adaptive output feedback protocols to achieve leader-follower consensus for any directed graph containing a directed spanning tree with the leader as the root. The proposed protocols are independent of any global information of the graph and can be constructed as long as the agents are stabilizable and detectable.",
        "keywords": [
            "Multi-agent systems",
            "Consensus",
            "Output feedback control",
            "Adaptive control",
            "Distributed tracking"
        ],
        "authors": [
            {
                "name": "Yuezu Lv",
                "org": "State Key Laboratory for Turbulence and Complex Systems, Department of Mechanics and Aerospace Engineering, College of Engineering, Peking University, Beijing 100871, China"
            },
            {
                "name": "Zhongkui Li",
                "org": "State Key Laboratory for Turbulence and Complex Systems, Department of Mechanics and Aerospace Engineering, College of Engineering, Peking University, Beijing 100871, China"
            },
            {
                "name": "Zhisheng Duan",
                "org": "State Key Laboratory for Turbulence and Complex Systems, Department of Mechanics and Aerospace Engineering, College of Engineering, Peking University, Beijing 100871, China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electrical Engineering, City University of Hong Kong, Kowloon, Hong Kong"
            },
            {
                "name": "",
                "org": ""
            }
        ],
        "venue": "Automatica",
        "year": 2016
    },
    "QbIV1c9K": {
        "id": "QbIV1c9K",
        "title": "Bipartite consensus of multi-agent systems over signed graphs: State feedback and output feedback control approaches",
        "abstract": "SummaryThis paper studies bipartite consensus problems for continuous-time multi-agent system over signed directed graphs. We consider general linear agents and design both state feedback and dynamic output feedback control laws for the agents to achieve bipartite consensus. Via establishing an equivalence between bipartite consensus problems and the conventional consensus problems under both state feedback and output feedback control approaches, we make direct application of existing state feedback and output feedback consensus algorithms to solve bipartite consensus problems. Moreover, we propose a systematical approach to design bipartite consensus control laws. Copyright \u00a9 2016 John Wiley u0026 Sons, Ltd.",
        "keywords": "",
        "authors": [
            {
                "name": "Hongwei Zhang",
                "org": "School of Electrical Engineering; Southwest Jiaotong University; Chengdu Sichuan 610031 China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Kowloon, Hong Kong"
            }
        ],
        "venue": "International Journal of Robust and Nonlinear Control",
        "year": 2017
    },
    "gTahZVP8": {
        "id": "gTahZVP8",
        "title": "Bounds on Delay Consensus Margin of Second-Order Multi-Agent Systems with Robust Position and Velocity Feedback Protocol",
        "abstract": "This paper studies the delay consensus margin and its bounds for second-order multiagent systems to achieve robust consensus with respect to uncertain delays varying within a range. This paper attempts to answer the question: What is the largest delay range within which a control protocol is able to achieve and maintain the consensus? We consider second-order agents with unstable poles, which communicate over an undirected network topology, and derive explicit bounds on the delay consensus margin. The results show that the consensuability robustness of such unstable agents depends on the pole locations of the agents, as well as on the eigenratio of the network graph.",
        "keywords": [
            "Delays",
            "Matrix decomposition",
            "Symmetric matrices",
            "Multi-agent systems",
            "Network topology"
        ],
        "authors": [
            {
                "name": "Dan Ma",
                "org": "College of Information Science and Engineering, State Key Laboratory of Synthetical Automation for Process Industries, Northeastern University, Shenyang, China"
            },
            {
                "name": "Rui Tian",
                "org": "College of Information Science and Engineering, State Key Laboratory of Synthetical Automation for Process Industries, Northeastern University, Shenyang, China"
            },
            {
                "name": "Adil Zulfiqar",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Hong Kong"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Hong Kong"
            },
            {
                "name": "Tianyou Chai",
                "org": "State Key Laboratory of Synthetical Automation for Process Industries, Northeastern University, Shenyang, China"
            }
        ],
        "venue": "IEEE Transactions on Automatic Control",
        "year": 2018
    },
    "21j6TA4X": {
        "id": "21j6TA4X",
        "title": "On logarithmic complementary sensitivity integrals for MIMO systems",
        "abstract": "Bode and Poisson type integral inequalities for the complementary sensitivity function are derived in this paper for multi-input multi-output systems, which generalize earlier work of a similar nature but only applicable to single-input single-output systems. The results characterize how open loop nonminimum phase zeros may adversely affect a system's performance, and how each of the zeros may couple with other nonminimum phase zeros and unstable poles to impose a severe limitation on the achievable performance quantified by the complementary sensitivity function, to which the zero directions are seen to play a central role",
        "keywords": [
            "mimo systems",
            "poles and zeros",
            "sensitivity analysis",
            "bode type integral inequalities",
            "poisson type integral inequalities",
            "complementary sensitivity function",
            "logarithmic complementary sensitivity integrals",
            "open loop nonminimum phase zeros",
            "unstable poles",
            "transfer functions",
            "noise reduction",
            "mimo",
            "system performance",
            "frequency",
            "noise measurement",
            "feedback loop"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Dept. of Electr. Eng., California Univ., Riverside, CA, USA|c|"
            }
        ],
        "venue": "American Control Conference, 1998. Proceedings of the 1998",
        "year": 1998
    },
    "71FFXFTi": {
        "id": "71FFXFTi",
        "title": "Worst-case asymptotic properties of /spl Hscr//sub /spl infin// identification",
        "abstract": "",
        "keywords": [
            "linear systems",
            "computational complexity",
            "frequency response",
            "numerical stability",
            "asymptotic stability",
            "identification",
            "frequency domain analysis",
            "polynomials"
        ],
        "authors": [
            {
                "name": "jie chen",
                "org": "university of california"
            },
            {
                "name": "guoxiang gu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2002
    },
    "epCvK8RH": {
        "id": "epCvK8RH",
        "title": "Control Under Stochastic Multiplicative Uncertainties: Part II, Optimal Design for Performance.",
        "abstract": "This paper studies the optimal control design problem for linear discrete-time systems with stochastic multiplicative uncertainties. These uncertainties are assumed to be present in the control inputs and modeled as independent and identically distributed (i.i.d.) random processes. The optimal performance under study is defined in the mean-square sense, referred to as the mean-square optimal H 2 performance. It is shown that the mean-square optimal H 2 control problem via state feedback can be solved using a mean-square stabilizing solution to a modified algebraic Riccati equation (MARE). A necessary and sufficient condition for the existence of this solution is presented, which constitutes a generalization of the solution to the classic optimal H 2 state feedback design problem, whereas the latter can be obtained by solving an algebraic Riccati equation (ARE). It is also proven that the optimal control design problem can be cast as an eigenvalue problem (EVP). For the output feedback case with possible input delays, we show that the mean-square optimal H 2 control problem also amounts to solving an MARE, when the plant has no nonminimum phase zeros from the inputs to the measurement outputs. That is, the global optimal solution is obtained by solving an MARE incorporating the delays. The implication is that in this case a separation principle still holds.",
        "keywords": [
            "Stochastic processes",
            "Uncertainty",
            "State feedback",
            "Linear systems",
            "Output feedback",
            "Optimal control",
            "Stability analysis"
        ],
        "authors": [
            {
                "name": "Weizhou Su",
                "org": "School of Automation Science and Engineering, Key Laboratory of Autonomous Systems and Networked Control, Ministry of Education, South China University of Technology, Guangzhou, China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Kowloon, Hong Kong"
            },
            {
                "name": "Minyue Fu",
                "org": "School of Electrical and Computer Engineering, University of Newcastle, Zhejiang University, Zhejiang, NSW, AustraliaChina"
            },
            {
                "name": "Tian Qi",
                "org": "School of Automation Science and Engineering, Key Laboratory of Autonomous Systems and Networked Control, Ministry of Education, South China University of Technology, Guangzhou, China"
            },
            {
                "name": "",
                "org": ""
            }
        ],
        "venue": "IEEE Trans. Automat. Contr.",
        "year": 2017
    },
    "KWJw6Jw7": {
        "id": "KWJw6Jw7",
        "title": "Control performance limitations: to achieve or not to achieve?",
        "abstract": "This tutorial is intended to provide a summary survey of the classical results and recent developments in control performance limitation studies. The topics of primary interest include such frequency-domain results as Bode and Poisson type integral relations, as well as time-domain developments on optimal tracking and regulation problems. The presentation focuses on multivariable systems and address a number of new, unique issues only found in multivariable systems.",
        "keywords": [
            "bode diagrams",
            "control system synthesis",
            "feedback",
            "frequency-domain analysis",
            "multivariable control systems",
            "optimal control",
            "time-domain analysis",
            "bode integrals",
            "poisson integrals",
            "feedback control",
            "multivariable systems",
            "optimal tracking",
            "performance limitations",
            "frequency domain",
            "frequency domain analysis",
            "time domain"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Dept. of Electr. Eng., California Univ., Riverside, CA, USA|c|"
            }
        ],
        "venue": "SICE 2003 Annual Conference",
        "year": 2003
    },
    "b7zym1ba": {
        "id": "b7zym1ba",
        "title": "Exact Computation of Delay Margin by PID Control: It Suffices to Solve a Unimodal Problem!",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jianqi Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Kowloon, SAR, China"
            },
            {
                "name": "Dan Ma",
                "org": "College of Information Science and Engineering, Northeastern University,Shenyang,China"
            },
            {
                "name": "Yong Xu",
                "org": "the school of Automation, Guangdong University of Technology, Guangzhou, China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Kowloon, SAR, China"
            }
        ],
        "venue": "chinese control conference",
        "year": 2019
    },
    "cZ9q2TJn": {
        "id": "cZ9q2TJn",
        "title": "Lower Bounds on Delay Margin of Second-Order Unstable Systems",
        "abstract": "Abstract   This paper examines the delay margin achievable by using PID controllers for linear time-invariant (LTI) systems subject to variable, unknown time delays. We derive explicit lower bounds on the delay margin of second-order unstable delay systems achievable by PID control, which provide  a priori  the ranges of delay over which a second-order delay plant is guaranteed to be stabilizable by a PID controller, and more generally, by a finite-dimensional LTI controller. Analysis shows that our results are less conservative in most cases than lower bounds obtained elsewhere using more sophisticated and general LTI controllers.",
        "keywords": "",
        "authors": [
            {
                "name": "Dan Ma",
                "org": ""
            },
            {
                "name": "Jianqi Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Hong Kong, China"
            },
            {
                "name": "Andong Liu",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Hong Kong, China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Hong Kong, China"
            },
            {
                "name": "Silviu-Iulian Niculescu",
                "org": "Laboratoire des Signaux et Syst\u00e8mes, CNRS-Sup\u00e9lec, 3, rue Joliot Curie, 91192, Gif-sur-Yvette, France"
            }
        ],
        "venue": "IFAC-PapersOnLine",
        "year": 2018
    },
    "aqlCEyGc": {
        "id": "aqlCEyGc",
        "title": "Robust stabilizability of MIMO delay systems: Bounds on delay radii.",
        "abstract": "The delay margin of a time-delay system constitutes the fundamental limit beyond which no single controller may exist to robustly stabilize an unstable delay plant for a range of delay values. For single-input single-output systems with a linear time-invariant controller, this margin is known to be finite, and bounds on the delay margin are available. This paper extends the existing results to multi-input multi-output systems. We derive upper bounds on a generalized notion called delay radius. Our results show that for a delay whose direction is orthogonal to that of an unstable pole, no limit is imposed by the pole, while if the delay direction is parallel to that of a nonminimum phase zero, its allowable range is further restricted.",
        "keywords": "",
        "authors": [
            {
                "name": "Tian Qi",
                "org": "School of Automation Science and Engineering, South China University of Technology, Guangzhou, China"
            },
            {
                "name": "Jing Zhu",
                "org": "College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China"
            }
        ],
        "venue": "RCAR",
        "year": 2016
    },
    "5lxiYXyn": {
        "id": "5lxiYXyn",
        "title": "H2 Tracking Performance Limitation in Sampled-Data Feedback Control",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Shinji Hara",
                "org": "Department of Information Physics and Computing, The University of Tokyo"
            },
            {
                "name": "Jie Chen",
                "org": "Dept. of Electrical Eng., Univ. of California"
            },
            {
                "name": "Li Qiu",
                "org": "Dept. of Electrical Eng., The Hong Kong Univ. of Science and Technology"
            },
            {
                "name": "Richard H. Middleton",
                "org": "Dept. of Electrical and Computer Eng., The Univ. of Newcastle"
            }
        ],
        "venue": "society of instrument and control engineers of japan",
        "year": 2002
    },
    "xw6J5zMz": {
        "id": "xw6J5zMz",
        "title": "Optimization of the H \u221e -norm of Dynamic Flow Networks.",
        "abstract": "In this paper, we study the H\u221e-norm of linear systems over graphs, which is used to model distribution networks. In particular, we aim to minimize the H\u221e-norm subject to allocation of the weights o ...",
        "keywords": "",
        "authors": [
            {
                "name": "Alexander Johansson",
                "org": "Royal Institute of Technology"
            },
            {
                "name": "Jieqiang Wei",
                "org": "Royal Institute of Technology"
            },
            {
                "name": "Henrik Sandberg",
                "org": "Royal Institute of Technology"
            },
            {
                "name": "Karl Henrik Johansson",
                "org": "Royal Institute of Technology"
            },
            {
                "name": "Jie Chen",
                "org": "City University of Hong Kong"
            }
        ],
        "venue": "advances in computing and communications",
        "year": 2018
    },
    "kjdhYMbK": {
        "id": "kjdhYMbK",
        "title": "Optimal tracking performance for SIMO systems",
        "abstract": "",
        "keywords": [
            "control systems",
            "linear systems",
            "frequency",
            "linear time invariant",
            "cost function",
            "tracking",
            "error correction",
            "actuators",
            "robust control",
            "indexing terms",
            "mimo",
            "feedback loop",
            "poles and zeros",
            "optimal control"
        ],
        "authors": [
            {
                "name": "gang chen",
                "org": "university of california"
            },
            {
                "name": "jie chen",
                "org": "university of california"
            },
            {
                "name": "richard h middleton",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Automatic Control",
        "year": 2002
    },
    "p5hpZGN9": {
        "id": "p5hpZGN9",
        "title": "Robust stability of quasipolynomials with commensurate delays",
        "abstract": "In this paper we study the robust stability of uncertain quasipolynomials, whose coefficients are only known to be confined within certain prescribed sets. We consider such quasipolynomials with commensurate delays. We derive a sufficient condition for the uncertain quasipolynomials to be robustly stable independent of delay, when they are confined to the families of interval, diamond, and spherical quasipolynomials. The condition requires checking the robust stability of one polynomial, and computing additionally a frequency-dependent matrix.",
        "keywords": [
            "delays",
            "polynomials",
            "stability",
            "commensurate delays",
            "diamond quasipolynomials",
            "frequency dependent matrix",
            "interval quasipolynomials",
            "robust stability",
            "spherical quasipolynomials",
            "sufficient condition",
            "uncertain quasipolynomials"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Dept. of Electr. Eng., California Univ., Riverside, CA, USA|c|"
            },
            {
                "name": "Niculescu, S.-I.",
                "org": ""
            }
        ],
        "venue": "Decision and Control, 2004. CDC. 43rd IEEE Conference",
        "year": 2004
    },
    "2cc8VqT2": {
        "id": "2cc8VqT2",
        "title": "Limitations on optimal tracking performance of discrete time systems",
        "abstract": "",
        "keywords": [
            "optimal control",
            "mimo",
            "displays",
            "error correction",
            "transfer functions",
            "linear systems",
            "stability",
            "poles and zeros",
            "feedback",
            "feedback control",
            "tracking",
            "multidimensional systems",
            "closed form expression"
        ],
        "authors": [
            {
                "name": "onur toker",
                "org": "university of california"
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "li qiu",
                "org": ""
            }
        ],
        "venue": "american control conference",
        "year": 1997
    },
    "NGKOOCHJ": {
        "id": "NGKOOCHJ",
        "title": "Mean-Square Stability Conditions for Linear Systems with Random Delays",
        "abstract": "In this paper we study stability properties of linear systems subject to random delays. We develop small-gain type mean-square stability conditions, by first obtaining small-gain mean-square robust stability conditions for systems containing multiplicative stochastic uncertainties and next, reformulating the random delay stability problem as one of robust stability against such uncertainties. The results allow us to determine stability using mean square criteria on the variances of the system under random delays, ascertaining whether the system\u2019s state variance matrix converges asymptotically to the zero matrix.",
        "keywords": "",
        "authors": [
            {
                "name": "Jianqi Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong Kowloon, Hong Kong SAR, China"
            },
            {
                "name": "Shengquan He",
                "org": "Department of Electronic Engineering, City University of Hong Kong Kowloon, Hong Kong SAR, China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong Kowloon, Hong Kong SAR, China"
            }
        ],
        "venue": "world congress on intelligent control and automation",
        "year": 2018
    },
    "eBRLtgPd": {
        "id": "eBRLtgPd",
        "title": "The Caratheodory-Fejer problem and H/sub /spl infin// identification: a time domain approach",
        "abstract": "",
        "keywords": [
            "interpolation",
            "identification",
            "convergence",
            "convex programming",
            "time series",
            "stability"
        ],
        "authors": [
            {
                "name": "jie chen",
                "org": "georgia institute of technology"
            },
            {
                "name": "c n nett",
                "org": ""
            }
        ],
        "venue": "conference on decision and control",
        "year": 1993
    },
    "FNp65V91": {
        "id": "FNp65V91",
        "title": "Extended argument principle and integral design constraints. II. New integral relations",
        "abstract": "For pt.1 see Proc. 39th IEEE Conf. Decision Contr., p.4984-89 (2000). This paper studies performance limitation and design tradeoff issues in the analysis and design of linear time-invariant, single-input single-output feedback control systems. We develop a number of integral constraints, which extend the classical Bode/Poisson sensitivity and complementary sensitivity integrals. The new integral relations lead to new insights into the study of fundamental limitation and design tradeoff issues, and together with the classical results, enable a more refined and more informative performance analysis",
        "keywords": [
            "bode diagrams",
            "poisson distribution",
            "control system analysis",
            "control system synthesis",
            "feedback",
            "linear systems",
            "sensitivity analysis",
            "bode/poisson sensitivity",
            "lti systems",
            "complementary sensitivity integrals",
            "control system design",
            "design tradeoff issues",
            "extended argument principle",
            "integral design constraints",
            "integral relations",
            "linear time-invariant siso feedback control systems",
            "performance analysis",
            "performance limitation issues",
            "stability analysis",
            "water",
            "frequency",
            "poles and zeros",
            "mimo",
            "transfer functions",
            "feedback control"
        ],
        "authors": [
            {
                "name": "Gang Chen",
                "org": "Dept. of Electr. Eng., California Univ., Riverside, CA, USA|c|"
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Qiu, L.",
                "org": ""
            }
        ],
        "venue": "Decision and Control, 2001. Proceedings of the 40th IEEE Conference",
        "year": 2001
    },
    "VZrkU8ny": {
        "id": "VZrkU8ny",
        "title": "Control Under Stochastic Multiplicative Uncertainties: Part I, Fundamental Conditions of Stabilizability.",
        "abstract": "In this two-part paper we study stabilization and optimal control of linear time-invariant systems with stochastic multiplicative uncertainties. We consider structured multiplicative perturbations, which, unlike in robust control theory, consist of static, zero-mean stochastic processes, and we assess the stability and performance of such systems using mean-square measures. While Part 2 of this paper tackles and solves optimal control problems under the mean-square criterion, Part 1 is devoted to the stabilizability problem. We develop fundamental conditions of mean-square stabilizability which ensure that an open-loop unstable system can be stabilized by output feedback in the mean-square sense. For single-input single-output systems, a general, explicit stabilizability condition is obtained. This condition, both necessary and sufficient, provides a fundamental limit imposed by the system's unstable poles, nonminimum phase zeros and time delay. For multi-input multi-output systems, we provide a complete, computationally efficient solution for minimum phase systems possibly containing time delays, in the form of a generalized eigenvalue problem readily solvable by means of linear matrix inequality optimization. Limiting cases and nonminimum phase plants are analyzed in depth for conceptual insights, revealing, among other things, how the directions of unstable poles and nonminimum phase zeros may affect mean-square stabilizability in MIMO systems. Other than their independent interest, stochastic multiplicative uncertainties have found utilities in modeling networked control systems pertaining to, e.g., packet drops, network delays, and fading. Our results herein lend solutions applicable to networked control problems addressing these issues.",
        "keywords": [
            "Uncertainty",
            "Stochastic processes",
            "Stability criteria",
            "Optimal control",
            "Poles and zeros",
            "MIMO"
        ],
        "authors": [
            {
                "name": "Tian Qi",
                "org": "School of Automation Science and Engineering, Key Laboratory of Autonomous Systems and Networked Control, Ministry of Education, South China University of Technology, Guangzhou, China"
            },
            {
                "name": "Jie Chen",
                "org": "School of Automation Science and Engineering, Key Laboratory of Autonomous Systems and Networked Control, Ministry of Education, South China University of Technology, Guangzhou, China"
            },
            {
                "name": "Weizhou Su",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Kowloon, Hong Kong"
            },
            {
                "name": "Minyue Fu",
                "org": "School of Electrical and Computer Engineering, University of Newcastle, Zhejiang University, Callaghan, Zhejiang, AustraliaChina"
            },
            {
                "name": "",
                "org": ""
            }
        ],
        "venue": "IEEE Trans. Automat. Contr.",
        "year": 2017
    },
    "79YylVUw": {
        "id": "79YylVUw",
        "title": "Fundamental Bounds for Stabilizability of Continuous-Time Systems under Stochastic Multiplicative Uncertainty and Delay",
        "abstract": "Abstract   This paper is devoted to stabilization problem of linear time-invariant (LTI) continuous-time systems under stochastic multiplicalive uncertainty and time-delay. In its full generality, we model the stochastic multiplicative uncertainty as a random process with a certain distribution. We assess the stability of system based on mean-square criteria. Our main contribution includes the fundamental condition, both necessary and sufficient, which insures that the single-input single-output systems (SISO) can be mean-square stabilized by output feedback. This condition provides explicitly a fundamental limit on mean-square staibilizability imposed by the signal-to-noise ratio (SNR), the system\u2019s unstable poles, nonminimum phase zeros and time-delay.",
        "keywords": "",
        "authors": [
            {
                "name": "Tian Qi",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "IFAC-PapersOnLine",
        "year": 2016
    },
    "fIKcSlu0": {
        "id": "fIKcSlu0",
        "title": "Sign-consensus of multi-agent systems over signed graphs with intermittent communications.",
        "abstract": "Sign-consensus is one of the newly emerged collective behaviors of multi-agent systems when cooperative and antagonistic interactions coexist among agents. This paper extends the results in a recent work [12] by allowing the graph to be time varying. It shows that the underlying graph only needs to be eventually positive for a suitable fraction of each time interval. In the rest of each time interval, the graph is allowed to have arbitrary topologies. A numerical example is given to illustrate the effectiveness of the control law.",
        "keywords": "",
        "authors": [
            {
                "name": "Ye Jiang",
                "org": "School of Electrical Engineering, Southwest Jiaotong University, Chengdu, Sichuan, 610031, P. R. China"
            },
            {
                "name": "Hongwei Zhang",
                "org": "School of Electrical Engineering, Southwest Jiaotong University, Chengdu, Sichuan, 610031, P. R. China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Hong Kong"
            }
        ],
        "venue": "CDC",
        "year": 2017
    },
    "GC2Pm36K": {
        "id": "GC2Pm36K",
        "title": "Validation of linear fractional uncertain models: solutions via matrix inequalities",
        "abstract": "A time domain approach is provided in this paper to tackle the problem of model validation pertaining to uncertain models described by linear fractional transforms. Both unstructured and structured dynamic uncertainties are considered. It is shown that in the first case the problem can be solved by finding a feasible solution to a convex optimization problem, while in the second case it amounts to solving a biaffine matrix inequality problem to which only a convex optimization-based necessary condition is given.",
        "keywords": [
            "Linear matrix inequalities",
            "Uncertainty",
            "Modeling",
            "Noise measurement",
            "Additive noise",
            "Mathematical model",
            "Control design",
            "Space technology",
            "Robust control",
            "Design methodology"
        ],
        "authors": [
            {
                "name": "jie chen",
                "org": "university of california"
            },
            {
                "name": "shuning wang",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Automatic Control",
        "year": 1996
    },
    "3i8aeq6F": {
        "id": "3i8aeq6F",
        "title": "H\u221e identification of multivariable systems by tangential interpolation methods",
        "abstract": "The purpose of this paper is to present an extension to some of the current work on worst-case identification problems to multivariable systems. We consider an H\u221e-identification problem for a class of linear shift invariant multi-input/multi-output systems. Our main results are an interpolatory algorithm and a number of bounds on the identification error. This algorithm operates on available input and output data in the time domain and is constructed by solving an extended matrix tangential Caratheodory-Fejer problem. Similar to its counterpart for scalar systems, this interpolatory algorithm possesses certain desirable optimality properties and can be obtained via standard convex programming methods",
        "keywords": [
            "H\u221e optimisation",
            "MIMO systems",
            "convex programming",
            "distributed parameter systems",
            "identification",
            "interpolation",
            "time-domain analysis",
            "transfer function matrices",
            "Caratheodory-Fejer problem",
            "H\u221e identification",
            "MIMO systems",
            "bounds",
            "convex programming",
            "distributed parameter systems",
            "identification error",
            "interpolation",
            "multivariable systems",
            "tangential interpolation",
            "time domain analysis",
            "transfer function matrix",
            "worst-case identification"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Coll. of Eng., California Univ., Riverside, CA, USA|c|"
            },
            {
                "name": "Farrell, J.A.",
                "org": ""
            },
            {
                "name": "Nett, C.N.",
                "org": ""
            },
            {
                "name": "Kemin Zhou",
                "org": ""
            }
        ],
        "venue": "Automatic Control, IEEE Transactions",
        "year": 1996
    },
    "7MG0iHHE": {
        "id": "7MG0iHHE",
        "title": "Performance limitations in estimation",
        "abstract": "",
        "keywords": [
            "brownian motion",
            "motion estimation",
            "white noise",
            "steady state",
            "parameter estimation",
            "noise measurement",
            "stochastic processes",
            "brownian noise"
        ],
        "authors": [
            {
                "name": "zhiyuan ren",
                "org": "carnegie mellon university"
            },
            {
                "name": "li qiu",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            }
        ],
        "venue": "conference on decision and control",
        "year": 1999
    },
    "3bw5CIvo": {
        "id": "3bw5CIvo",
        "title": "MAS Consensus and Delay Limits Under Delayed Output Feedback.",
        "abstract": "In this technical note, we study the consensus problem for discrete-time multi-agent systems over an undirected, fixed network communication graph, focusing on the robustness of consensus with respect to communication delay. We assume that the agents' input is subject to a constant albeit possibly unknown time delay, and is generated by a distributed dynamic output feedback control protocol. Drawing upon concepts and techniques from robust control, notably those concerning gain margin optimization and analytic interpolation, we derive explicit, closed-form conditions for general linear agents to achieve consensus. Our results display an explicit dependence of the consensus condition on the delay value as well as on the agent's unstable poles and non-minimum phase zeros, showing that delayed communication between agents will generally hinder consensus and impose restrictions on the network topology. We also show that a lower bound on the maximal delay allowable for consensus can be computed by a simple line search method.",
        "keywords": [
            "Delays",
            "Protocols",
            "Output feedback",
            "Network topology",
            "Robustness",
            "Delay effects",
            "Optimized production technology"
        ],
        "authors": [
            {
                "name": "Tian Qi",
                "org": "Center for Control and Optimization, School of Automation Science and Engineering, South China University of Technology, Guangzhou, China"
            },
            {
                "name": "Li Qiu",
                "org": "Department of Electronic and Computer Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Kowloon, Hong Kong"
            }
        ],
        "venue": "IEEE Trans. Automat. Contr.",
        "year": 2017
    },
    "drm2mqhs": {
        "id": "drm2mqhs",
        "title": "Computation of /spl Lscr//sub 2/[0, h] induced norms",
        "abstract": "",
        "keywords": [
            "multidimensional systems",
            "sampled data systems"
        ],
        "authors": [
            {
                "name": "guoxiang gu",
                "org": "louisiana state university"
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "onur toker",
                "org": ""
            }
        ],
        "venue": "conference on decision and control",
        "year": 1996
    },
    "4SP7pZ7l": {
        "id": "4SP7pZ7l",
        "title": "Mean square stabilization over SNR-constrained channels with colored and spatially correlated additive noises",
        "abstract": "This note addresses the problem of stabilizing a multi-input multi-output (MIMO) discrete-time linear time invariant (LTI) system over a MIMO additive noise channel. To treat this problem, we assume that the communication link between the plant output and the controller input consists of multiple additive colored mutually correlated noise channels subject to independent signal-to-noise ratio (SNR) constraints. We derive analytical conditions for which mean square stabilization (MSS) can be achieved under such constraints. We also formulate numerical methods to test these conditions when the noise is white and correlated. Moreover, for simpler plant models, a characterization of the set of power constraints compatible with MSS is obtained. Our results show that the frequency response of the spectral factor related to the channel noise affects the minimum SNR for stability depending mostly on the unstable poles and their directions. This is aggravated by the existence of nonminimum phase zeros and higher relative degree of the plant. On the other hand, we detect that systems under highly correlated noise show lower SNR requirements for stability compared to ones with independent noise channels. Numerical simulations are provided to illustrate the theoretical results.",
        "keywords": [
            "Signal to noise ratio",
            "MIMO communication",
            "Linear systems",
            "Stability analysis",
            "Additive noise",
            "Transfer functions",
            "Covariance matrices"
        ],
        "authors": [
            {
                "name": "Rodrigo A. Gonzalez",
                "org": "Department of Automatic Control, KTH Royal Institute of Technology, Stockholm, Sweden"
            },
            {
                "name": "Francisco J. Vargas",
                "org": "Electronic Engineering Department, Universidad T\u00e9cnica Federico Santa Mar\u00eda, Valpara\u00edso, Chile"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Hong Kong"
            }
        ],
        "venue": "IEEE Transactions on Automatic Control",
        "year": 2019
    },
    "4soBsNGe": {
        "id": "4soBsNGe",
        "title": "Robust Consensus of Linear Feedback Protocols Over Uncertain Network Graphs.",
        "abstract": "In this paper, we study the robust consensus problem for a group of linear discrete-time or continuous-time agents to coordinate over an uncertain communication network, which is to achieve consensus against transmission errors and noises. We model the network by communication links subject to deterministic uncertainties, which can be additive perturbations described by either some unknown transfer functions or norm bounded matrices. We show that the robust consensus problem can generally be solved by solving a simultaneous H control problem for a set of low-dimensional subsystems. We also derive necessary conditions for the existence of a protocol achieving robust consensus. The results show that for discrete-time agents the uncertainty size must not exceed the inverse of the Mahler measure of the agents, while for continuous-time agents it must be less than the unity. Sufficient conditions in terms of linear matrix inequalities are further presented to design the robust consensus protocols.",
        "keywords": [
            "Uncertainty",
            "Robustness",
            "Protocols",
            "Communication channels",
            "Transfer functions",
            "Multi-agent systems",
            "Eigenvalues and eigenfunctions"
        ],
        "authors": [
            {
                "name": "Zhongkui Li",
                "org": "State Key Laboratory for Turbulence and Complex Systems, Department of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing, China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Kowloon, Hong Kong"
            },
            {
                "name": "",
                "org": ""
            }
        ],
        "venue": "IEEE Trans. Automat. Contr.",
        "year": 2017
    },
    "ayw22EDW": {
        "id": "ayw22EDW",
        "title": "Fundamental Limits on Uncertain Delays: When Is a Delay System Stabilizable by LTI Controllers?",
        "abstract": "This paper concerns the stabilization of linear time-invariant (LTI) systems subject to uncertain, possibly time-varying delays. The fundamental issue under investigation, referred to as the delay margin problem, addresses the question: What is the largest range of delay such that there exists a single LTI feedback controller capable of stabilizing all the plants for delays within that range? Drawing upon analytic interpolation and rational approximation techniques, we derive fundamental bounds on the delay margin, within which the delay plant is guaranteed to be stabilizable by a certain LTI output feedback controller. Our contribution is threefold. First, for single-input single-output (SISO) systems with an arbitrary number of plant unstable poles and nonminimum phase zeros, we provide an explicit, computationally efficient bound on the delay margin, which requires computing only the largest real eigenvalue of a constant matrix. Second, for multi-input multi-output (MIMO) systems, we show that estimates on the variation ranges of multiple delays can be obtained by solving LMI problems, and further, by finding bounds on the radius of delay variations. Third, we show that these bounds and estimates can be extended to systems subject to time-varying delays. When specialized to more specific cases, e.g., to plants with one unstable pole but possibly multiple nonminimum phase zeros, our results give rise to analytical expressions exhibiting explicit dependence of the bounds and estimates on the pole and zeros, thus demonstrating how fundamentally unstable poles and nonminimum phase zeros may limit the range of delays over which a plant can be stabilized by a LTI controller.",
        "keywords": [
            "Delays",
            "Linear systems",
            "Poles and zeros",
            "Robustness",
            "Interpolation",
            "Stability analysis",
            "Delay systems"
        ],
        "authors": [
            {
                "name": "Tian Qi",
                "org": "School of Automation Science and Engineering, South China University of Technology, Guangzhou, China"
            },
            {
                "name": "Jing Zhu",
                "org": "Collage of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Kowloon, Hong Kong"
            }
        ],
        "venue": "IEEE Trans. Automat. Contr.",
        "year": 2017
    },
    "sXj0PCYS": {
        "id": "sXj0PCYS",
        "title": "Intrinsic performance limits of linear feedback control",
        "abstract": "Nevanlinna-Pick interpolation techniques are employed in this paper to derive for multivariable systems exact expressions\n and bounds for the best attainable H\n \u221e norms of the sensitivity and complementary sensitivity functions. These results improve the previously known performance\n bounds and provide intrinsic limits on the performance of feedback systems irreducible via compensator design, leading to\n new insights toward the understanding of fundamental limitations in feedback control. It becomes clear that in a multivariable\n system the best achievable performance is constrained by plant nonminimum phase zeros and unstable poles, and additionally,\n is dependent on the mutual orientation of the zero and pole directions.\n ",
        "keywords": [],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "University of California Department of Electrical Engineering 92521 Riverside CA"
            }
        ],
        "venue": "",
        "year": 1999
    },
    "kssWEwM2": {
        "id": "kssWEwM2",
        "title": "Some new thoughts and findings on Bode integrals",
        "abstract": "This paper establishes relationships between Bode type sensitivity and complementary sensitivity integral relations and optimal tracking and regulation performance, where the latter are defined in quadratic measures. These relationships link together frequency and time domain performance constraints, and further lead to new insight into these two independent areas of research.",
        "keywords": [
            "feedback",
            "integral equations",
            "sensitivity analysis",
            "tracking",
            "bode integrals",
            "bode type sensitivity integral relations",
            "complementary sensitivity integral relations",
            "optimal tracking",
            "time domain"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Dept. of Electr. Eng., California Univ., Riverside, CA, USA|c|"
            },
            {
                "name": "Gang Chen",
                "org": ""
            }
        ],
        "venue": "SICE 2004 Annual Conference",
        "year": 2004
    },
    "aQjqHABc": {
        "id": "aQjqHABc",
        "title": "Erratum: \u201cX-ray photoelectron spectroscopy study of irradiation-induced amorphization of Gd2Ti2O7Gd2Ti2O7 [Appl. Phy. Lett. 79, 1989 (2001)]",
        "abstract": "",
        "keywords": [
            "titanium",
            "radioactive waste disposal",
            "binding energy",
            "transmission electron microscopy",
            "ion beam",
            "x ray photoelectron spectroscopy",
            "physics"
        ],
        "authors": [
            {
                "name": "jungchieh chen",
                "org": "university of michigan"
            },
            {
                "name": "j lian",
                "org": "university of michigan"
            },
            {
                "name": "l m wang",
                "org": "university of michigan"
            },
            {
                "name": "rodney c ewing",
                "org": "university of michigan"
            },
            {
                "name": "l a boatner",
                "org": "oak ridge national laboratory"
            }
        ],
        "venue": "Applied Physics Letters",
        "year": 2002
    },
    "sV5IAJW7": {
        "id": "sV5IAJW7",
        "title": "Paper: Sensitivity integrals for multivariable discrete-time systems",
        "abstract": "The purpose of this paper is to develop integral formulae for singular values of the sensitivity function to express design constraints in multivariable discrete-time systems. We present extensions to both the classical Poisson integral and Bode's sensitivity integral formulae. The main utility of these results is that they can be used to quantify design limitations that arise in multivariable discrete-time systems, due to such system characteristics as open-loop unstable poles and nonminimum-phase zeros, and to such design requirements as stability and bandwidth constraints. These formulae are similar to those for multivariable continuous-time systems obtained elsewhere, and they reveal that feedback design limitations depend on directionality properties of the sensitivity function, and on those of unstable poles and nonminimum-phase zeros in the open loop transfer function.",
        "keywords": [
            "design constraint",
            "feedback design limitation",
            "nonminimum-phase zero",
            "integral formula",
            "design requirement",
            "sensitivity integral",
            "open loop transfer function",
            "multivariable continuous-time system",
            "design limitation",
            "sensitivity function",
            "multivariable discrete-time system"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "College of Engineering, University of California, Riverside, CA 92521-0425, U.S.A."
            },
            {
                "name": "Carl N. Nett",
                "org": "United Technology Research Center, 411 Silver Lane, East Hartford, CT 06108, U.S.A."
            }
        ],
        "venue": "Automatica (Journal of IFAC)",
        "year": 1995
    },
    "R5oMf2ke": {
        "id": "R5oMf2ke",
        "title": "Model validation in l/sub 1/ using frequency-domain data",
        "abstract": "",
        "keywords": [
            "multidimensional systems",
            "frequency domain analysis"
        ],
        "authors": [
            {
                "name": "wenguo liu",
                "org": "university of california"
            },
            {
                "name": "jie chen",
                "org": "university of california"
            }
        ],
        "venue": "conference on decision and control",
        "year": 2003
    },
    "dbYvBSoY": {
        "id": "dbYvBSoY",
        "title": "Best tracking and regulation performance under control effort constraint: Two-parameter controller c",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "shinji hara",
                "org": ""
            },
            {
                "name": "gang chen",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2002
    },
    "MbSJ0ic1": {
        "id": "MbSJ0ic1",
        "title": "Sign-consensus over cooperative-antagonistic networks with switching topologies: Sign-consensus over cooperative-antagonistic networks",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Ye Jiang",
                "org": "Key Laboratory of Magnetic Suspension Technology and Maglev Vehicle, Ministry of Education; School of Electrical Engineering, Southwest Jiaotong University; Chengdu China"
            },
            {
                "name": "Hongwei Zhang",
                "org": "Key Laboratory of Magnetic Suspension Technology and Maglev Vehicle, Ministry of Education; School of Electrical Engineering, Southwest Jiaotong University; Chengdu China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering; City University of Hong Kong; Hong Kong"
            }
        ],
        "venue": "International Journal of Robust and Nonlinear Control",
        "year": 2018
    },
    "UhKc3SMi": {
        "id": "UhKc3SMi",
        "title": "Asymptotic stability independent of delays: simple necessary and sufficient conditions",
        "abstract": "Studies stability properties of linear time-invariant delay systems. The authors consider specifically the notion of asymptotic stability independent of delays. Systems with both commensurate and non-commensurate delays are investigated. The authors present for each case a necessary and sufficient condition, and further they demonstrate how these conditions may be extended readily to study asymptotic stability independent of delays for uncertain systems. These conditions can be readily checked, and they appear to be considerably simpler than results developed elsewhere previously.",
        "keywords": [
            "asymptotic stability",
            "delay systems",
            "linear systems",
            "uncertain systems",
            "commensurate delays",
            "linear time-invariant delay systems",
            "necessary and sufficient condition",
            "noncommensurate delays",
            "linear time invariant"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Coll. of Eng., California Univ., Riverside, CA, USA|c|"
            },
            {
                "name": "Latchman, H.A.",
                "org": ""
            }
        ],
        "venue": "American Control Conference, 1994",
        "year": 1994
    },
    "8Qpd7oqP": {
        "id": "8Qpd7oqP",
        "title": "Robust adaptive control of systems with nonlinear unmodeled dynamics",
        "abstract": "",
        "keywords": [
            "robust control",
            "design method",
            "control systems",
            "tracking",
            "control theory",
            "backstepping",
            "design methodology",
            "robustness",
            "nonlinear systems",
            "adaptive control",
            "uncertainty"
        ],
        "authors": [
            {
                "name": "zhongping jiang",
                "org": "university of california"
            },
            {
                "name": "david j hill",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            }
        ],
        "venue": "conference on decision and control",
        "year": 1998
    },
    "FtoYIOZL": {
        "id": "FtoYIOZL",
        "title": "Computation of \u2112/sub 2/[0, h] induced norms",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Guoxiang Gu",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Onur Toker",
                "org": ""
            }
        ],
        "venue": "conference on decision and control",
        "year": 1996
    },
    "SP5CXx8q": {
        "id": "SP5CXx8q",
        "title": "The Caratheodory-Fejer problem and H\u221e identification: a time domain approach",
        "abstract": "Addresses a worst-case, robust control oriented identification problem. This problem is a variant in the general framework of H\u221e identification problems which have been studied by several authors. In this problem the available a priori information consists of a lower bound on the relative stability of the plant, an upper bound on a certain gain associated with the plant, and an upper bound on the noise level. The plant to be identified is assumed to lie in a certain subset in the space of H\u221e. The available experimental information consists of a corrupt finite output time series obtained in response to a known nonzero but otherwise arbitrary input. The objective is to identify from the given a priori and experimental information an uncertain model which includes a nominal plant model in H \u221e and a bound on the modeling error measured in H\u221e norm. The authors present both an identification error and several explicit lower and upper bounds on the identification error. The proposed algorithm is in the class of interpolatory algorithms which are known to posses desirable optimality properties in reducing the identification error. This algorithm may be obtained by solving an extended Caratheodory-Fejer problem via standard convex programming methods. The error bounds not only provide explicit estimates on the modeling error, but also are used to establish the convergence properties of the proposed identification algorithm",
        "keywords": [
            "convergence",
            "convex programming",
            "identification",
            "interpolation",
            "stability",
            "time series",
            "Caratheodory-Fejer problem",
            "H\u221e identification",
            "corrupt finite output time series",
            "identification error",
            "interpolatory algorithms",
            "modeling error",
            "nominal plant model",
            "optimality properties",
            "relative stability",
            "standard convex programming methods",
            "time domain approach",
            "uncertain model",
            "worst-case robust control oriented identification problem"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Sch. of Aerosp. & Electr. Eng., Georgia Inst. of Technol., Atlanta, GA, USA|c|"
            },
            {
                "name": "Nett, C.N.",
                "org": ""
            }
        ],
        "venue": "San Antonio, TX",
        "year": 1993
    },
    "BCzyjKwL": {
        "id": "BCzyjKwL",
        "title": "Mean-square stabilizability via output feedback for a non-minimum phase networked feedback system",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jieying Lu",
                "org": "School of Automation Science and Engineering, South China University of Technology, China"
            },
            {
                "name": "Weizhou Su",
                "org": "School of Automation Science and Engineering, South China University of Technology, China"
            },
            {
                "name": "Yilin Wu",
                "org": "Department of Computer Science, Guangdong University of Education, China"
            },
            {
                "name": "Minyue Fu",
                "org": "School of Electrical and Computer Engineering, University of Newcastle, Australia"
            },
            {
                "name": "Jie Chen",
                "org": "Dept. of electronic engineering, City University of Hong kong, China"
            }
        ],
        "venue": "Automatica",
        "year": 2019
    },
    "esTlVJSL": {
        "id": "esTlVJSL",
        "title": "Limitations on maximal tracking accuracy. 2. Tracking sinusoidal and ramp signals",
        "abstract": "",
        "keywords": [
            "steady state",
            "feedback system",
            "linear systems",
            "feedback",
            "mimo",
            "signal analysis",
            "laplace transforms",
            "poles and zeros",
            "tracking",
            "multidimensional systems",
            "degradation"
        ],
        "authors": [
            {
                "name": "jie chen",
                "org": "university of california"
            },
            {
                "name": "li qiu",
                "org": ""
            },
            {
                "name": "onur toker",
                "org": ""
            }
        ],
        "venue": "american control conference",
        "year": 1997
    },
    "9hOm3whN": {
        "id": "9hOm3whN",
        "title": "Best achievable tracking performance in sampled-data control systems",
        "abstract": "In this paper we study the problem of tracking a step reference signal using sampled-data control systems. We investigate the best achievable tracking performance, where the performance is deemed best for it is the minimal attainable by all possible sampled-data stabilizing controllers. Our primary objective is to investigate the fundamental tracking performance limit in sampled-data systems, and to understand whether and how sampling and hold in a sampled-data system may impose intrinsic barriers to performance. For this purpose we derive an analytical expression for the optimal tracking performance. The result shows that a performance loss is generally incurred in a sampled-data system, in comparison to the tracking performance achievable by continuous-time controllers. This loss of performance, as so demonstrated by the expression, can be attributed to the non-minimum behaviors and the aliasing effects generated by samplers and hold devices.",
        "keywords": [
            "control system analysis",
            "feedback",
            "optimal control",
            "sampled data systems",
            "tracking",
            "h2 control",
            "aliasing effects",
            "continuous time controllers",
            "hold devices",
            "intrinsic barriers",
            "nonminimum behaviors",
            "nonminimum phase zeros",
            "optimal tracking",
            "performance loss",
            "performance tracking",
            "sampled data control systems",
            "samplers",
            "stabilizing controllers",
            "step reference signal",
            "feedback system"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Dept. of Electr. Eng., California Univ., Riverside, CA, USA|c|"
            },
            {
                "name": "Hara, S.",
                "org": ""
            },
            {
                "name": "Qiu, L.",
                "org": ""
            },
            {
                "name": "Middleton, R.",
                "org": ""
            }
        ],
        "venue": "Decision and Control, 2002, Proceedings of the 41st IEEE Conference",
        "year": 2002
    },
    "V5jMgH58": {
        "id": "V5jMgH58",
        "title": "LFT uncertain model validation with time and frequency domain measurements",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Demin Xu",
                "org": ""
            },
            {
                "name": "Zhang Ren",
                "org": ""
            },
            {
                "name": "Guoxiang Gu",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "conference on decision and control",
        "year": 1997
    },
    "7nbp7n9V": {
        "id": "7nbp7n9V",
        "title": "Limitations on maximal tracking accuracy. I. Tracking step signals",
        "abstract": "",
        "keywords": [
            "feedback",
            "poles and zeros",
            "mimo",
            "control systems",
            "feedback control",
            "linear systems",
            "optimal control",
            "tracking",
            "tracking error",
            "error correction",
            "multidimensional systems",
            "steady state",
            "linear time invariant",
            "stability"
        ],
        "authors": [
            {
                "name": "jie chen",
                "org": "university of california"
            },
            {
                "name": "li qiu",
                "org": ""
            },
            {
                "name": "onur toker",
                "org": ""
            }
        ],
        "venue": "conference on decision and control",
        "year": 1996
    },
    "ASPeK7Nc": {
        "id": "ASPeK7Nc",
        "title": "Asymptotic Behavior of Imaginary Zeros of Linear Systems with Commensurate Delays",
        "abstract": "This paper addresses the problem of asymptotic stability of linear time-delay systems with commensurate delays. We study the asymptotic behavior of the critical characteristic zeros of such systems on the imaginary axis. This behavior determines whether the imaginary zeros cross from one half plane into another, and hence plays a critical role in determining the stability of a time-delay system. We consider time-delay systems given in both state-space form and as a quasipolynomial. Our results reveal that in the former case the zero asymptotic behavior can be characterized by solving a simple eigenvalue problem, and in the latter case, by computing the derivatives of the quasipolynomial. To perform such an analysis, we make use of an operator perturbation approach",
        "keywords": [
            "asymptotic stability",
            "delay systems",
            "eigenvalues and eigenfunctions",
            "perturbation techniques",
            "poles and zeros",
            "polynomials",
            "state-space methods",
            "asymptotic behavior",
            "commensurate delays",
            "critical zeros",
            "eigenvalue problem",
            "imaginary zeros",
            "linear time-delay systems",
            "matrix pencil",
            "operator perturbation approach",
            "quasipolynomial",
            "state-space form",
            "time-delay",
            "state space",
            "linear system",
            "linear time",
            "state space form"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Dept. of Electr. Eng., California Univ., Riverside, CA|c|"
            },
            {
                "name": "Peilin Fu",
                "org": ""
            },
            {
                "name": "Niculescu, S.-I.",
                "org": ""
            }
        ],
        "venue": "San Diego, CA",
        "year": 2006
    },
    "M1XKCq6f": {
        "id": "M1XKCq6f",
        "title": "Robust stability and stability radius for linear time delay systems with multi-structure perturbations",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Bahram Shafai",
                "org": "Electrical and Computer Engineering, Northeastern University, Boston"
            },
            {
                "name": "Hanai Sadaka",
                "org": "Mechanical and Industrial Engineering, Northeastern University, Boston"
            },
            {
                "name": "Rifat Sipahi",
                "org": "Mechanical and Industrial Engineering, Northeastern University, Boston"
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "IFAC Proceedings Volumes",
        "year": 2007
    },
    "MzsCMfAC": {
        "id": "MzsCMfAC",
        "title": "Tradeoffs in Networked Feedback Systems: From Information-Theoretic Measures to Bode-Type Integrals.",
        "abstract": "This paper investigates performance limitation issues of multivariable networked feedback systems with multiport communication channels. We develop a general information-theoretic paradigm for analyzing the limitations and tradeoffs imposed by communication channels, which is enabled by the development of new information measures and Bode-type integral inequalities. The integral inequalities quantify the tradeoffs in disturbance attenuation for broad classes of systems consisting of linear time-invariant plants and causal, possibly nonlinear, time-varying stabilizing controllers communicating over general noisy channels with causal encoders and decoders. The channel blurredness, a newly developed information measure for the quality of multiport communication channels, is used to characterize the effect of communication channel constraints on the integrals and henceforth the tradeoff in disturbance attenuation. For several canonical channels with power constraints, such as additive white Gaussian noise channels, additive colored Gaussian noise channels, and fading channels, we derive explicit forms for the channel blurredness, which, together with the Bode-type integral inequalities, show that to mitigate the noise effect on performance tradeoff, the power of the communication channels must be distributed in ways fundamentally different from the Shannon's classical water-filling power allocation policy.",
        "keywords": [
            "Entropy",
            "Communication channels",
            "MIMO",
            "Noise measurement",
            "Sensitivity",
            "Covariance matrices",
            "Attenuation"
        ],
        "authors": [
            {
                "name": "Song Fang",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Hong Kong"
            },
            {
                "name": "Hideaki Ishii",
                "org": "Department of Computer Science, Tokyo Institute of Technology, Yokohama, Japan"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Hong Kong"
            }
        ],
        "venue": "IEEE Trans. Automat. Contr.",
        "year": 2017
    },
    "1hsNpISf": {
        "id": "1hsNpISf",
        "title": "Optimization of the $\\mathcal{H}_{\\infty}$ -norm of Dynamic Flow Networks",
        "abstract": "In this paper, we study the  $mathcal{H}_{infty}$ -norm of linear systems over graphs, which is used to model distribution networks. In particular, we aim to minimize the  $mathcal{H}_{infty}$ -norm subject to allocation of the weights on the edges. The optimization problem is formulated with LMI (Linear-Matrix-Inequality) constraints. For distribution networks with one port, i.e., SISO systems, we show that the  $mathcal{H}_{infty}$ -norm coincides with the effective resistance between the nodes in the port. Moreover, we derive an upper bound of the  $mathcal{H}_{infty}$ -norm, which is in terms of the algebraic connectivity of the graph on which the distribution network is defined.",
        "keywords": "",
        "authors": [
            {
                "name": "Alexander Johansson",
                "org": "School of Electrical Engineering, KTH Royal Institute of Technology, ACCESS Linnaeus Centre, Stockholm, SE-10044, Sweden"
            },
            {
                "name": "Jieqiang Wei",
                "org": "City University of Hong Kong, Department of Electronic Engineering, Hong Kong, China"
            },
            {
                "name": "Karl Henrik Johansson",
                "org": "School of Electrical Engineering, KTH Royal Institute of Technology, ACCESS Linnaeus Centre, Stockholm, SE-10044, Sweden"
            },
            {
                "name": "Jie Chen",
                "org": "City University of Hong Kong, Department of Electronic Engineering, Hong Kong, China"
            }
        ],
        "venue": "advances in computing and communications",
        "year": 2018
    },
    "N6YdrLZm": {
        "id": "N6YdrLZm",
        "title": "Analytical Modeling of Electromigration Failure for VLSI Interconnect Tree Considering Temperature and Segment Length Effects",
        "abstract": "Electromigration (EM) is a major concern for very large-scale integration (VLSI) interconnect reliability, particularly for interconnect trees with multibranch metal wires representing continuously connected metal (Cu) lines terminated at diffusion barriers. For EM modeling and assessment, one important problem is to perform fast EM time to failure analysis for practical VLSI chips. Compact modeling for EM effects for the interconnect tree has been studied recently to better EM signoff analysis. But the existing method cannot consider wires stressed under time-varying temperature, which is very typical for practical chip working conditions. In this paper, we develop the exact analytic model for the stress evolution of interconnect trees under different current density and varying segment length from the first principle. Due to the difficulty in obtaining the exact analytical solution, we focus on three-terminal wire in this paper. The stress evolution is modeled by two Korhonen\u2019s equations coupled through boundary conditions which are solved with the Laplace transformation technique. The new analytical EM model is further extended to consider the time-varying temperature stressing condition and initial non-zero residual stress. The proposed method is compared with the finite-element method (FEM) tool COMSOL, the recently proposed eigenfunction-based method, and the published EM simulator XSim. The comparison shows that the analytical solution agrees well with the results from the FEM numerical analysis. It uses much fewer terms compared to the eigenfunction method for the same accuracy. It also agrees very well with XSim, which is consistent with the previously reported measured results.",
        "keywords": "",
        "authors": [
            {
                "name": "Hai-Bao Chen",
                "org": "Department of Micro/Nano-Electronics, Shanghai Jiao Tong University, Shanghai, China"
            },
            {
                "name": "Sheldon X.-D. Tan",
                "org": "Department of Electrical and Computer Engineering, University of California at Riverside, Riverside, CA, USA"
            },
            {
                "name": "Jiangtao Peng",
                "org": "Department of Micro/Nano-Electronics, Shanghai Jiao Tong University, Shanghai, China"
            },
            {
                "name": "Taeyoung Kim",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Hong Kong, China"
            }
        ],
        "venue": "IEEE Transactions on Device and Materials Reliability",
        "year": 2017
    },
    "dlQIfc5f": {
        "id": "dlQIfc5f",
        "title": "Probabilistic bounds for model invalidation assessment",
        "abstract": "",
        "keywords": [
            "gaussian distribution",
            "upper and lower bounds",
            "satisfiability",
            "probabilistic model",
            "time series",
            "input output",
            "time domain",
            "identification",
            "probability"
        ],
        "authors": [
            {
                "name": "wenguo liu",
                "org": "university of california"
            },
            {
                "name": "jie chen",
                "org": "university of california"
            }
        ],
        "venue": "conference on decision and control",
        "year": 2004
    },
    "hTkpQdXS": {
        "id": "hTkpQdXS",
        "title": "Optimal tracking performance: preview control and exponential signals",
        "abstract": "",
        "keywords": [
            "stability",
            "tracking",
            "interpolation",
            "distortion",
            "exact solution",
            "control systems",
            "optimal control",
            "signal processing",
            "feedback control",
            "feedback",
            "predictive control",
            "informatics"
        ],
        "authors": [
            {
                "name": "zhang ren",
                "org": "university of california"
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "shinji hara",
                "org": ""
            },
            {
                "name": "li qiu",
                "org": ""
            }
        ],
        "venue": "conference on decision and control",
        "year": 2000
    },
    "PHDPLQ3q": {
        "id": "PHDPLQ3q",
        "title": "On computational complexity of invalidating structured uncertainty models 1 1 This research is suppo",
        "abstract": "",
        "keywords": [
            "computational complexity",
            "numerical method",
            "frequency response",
            "linear matrix inequality",
            "input output",
            "time series",
            "model validation"
        ],
        "authors": [
            {
                "name": "onur toker",
                "org": "king fahd university of petroleum and minerals"
            },
            {
                "name": "jie chen",
                "org": "university of california riverside"
            }
        ],
        "venue": "Systems & Control Letters",
        "year": 1998
    },
    "EQMgIwK4": {
        "id": "EQMgIwK4",
        "title": "Stability Radius Characterization of L\u03c3-Gain for Positive Systems and its Significance in Stabilization with Optimal Performance",
        "abstract": "Abstract   This paper provides a connection between stability radius and  L  \u03c3 -gain of positive systems. The  L  1 -,  L  2 -, and  L  \u221e -gains of an asymptotically stable positive system are characterized in terms of stability radii and useful bounds are derived. We show that the structured perturbations of a stable matrix can be regarded as a closed-loop system with unknown static output feedback, which makes it possible to obtain the main results of this paper. In particular, we use the closed-form expressions for stability radii of positive systems to compute the  L  \u03c3 -gains without resorting to solve optimization problems. We also show that positive stabilization with maximum stability radius can be considered as an  L  2 -gain minimization, which can be solved by LMI. This inherently achieves performance criterion and establishes a link to the reported LP formulations. A significant result of this paper is the unique commonality among the optimal state feedback gain matrices in obtaining  L  \u03c3 -gains of the stabilized system. Numerical examples are provided to support the theoretical results.",
        "keywords": "",
        "authors": [
            {
                "name": "Bahram Shafai",
                "org": "Department of Electrical and Computer Engineering Northeastern University Boston, MA 02115"
            },
            {
                "name": "Mohammad Naghnaeian",
                "org": "Department of Mechanical Engineering Massachusetts Institute of Technology Cambridge MA 02139-4307"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering City University of Hong Kong"
            }
        ],
        "venue": "IFAC-PapersOnLine",
        "year": 2018
    },
    "ieIueFXe": {
        "id": "ieIueFXe",
        "title": "Bounds on generalized structured singular values",
        "abstract": "The authors present several bounds on the structured singular value (SSV). They first adopt a generalized notion of which is useful for problems where uncertainties are assumed to be bounded in an l p-induced matrix norm. Two different types of bounds, in terms of Perron root and interaction parameters, respectively, are given for the new SSV, and their relations are discussed. These bounds are useful in that they are easy to compute and may be further analyzed to provide insights useful in design",
        "keywords": [
            "control system synthesis",
            "matrix algebra",
            "stability criteria",
            "perron root",
            "bounds",
            "generalized structured singular values",
            "robustness",
            "stability",
            "uncertainties",
            "uncertainty",
            "upper bound",
            "design optimization",
            "aerospace engineering",
            "feedback"
        ],
        "authors": [
            {
                "name": "Chen, Jie",
                "org": "Georgia Inst. of Technol., Atlanta, GA, USA|c|"
            },
            {
                "name": "Nett, C.N.",
                "org": ""
            }
        ],
        "venue": "Tucson, AZ",
        "year": 1992
    },
    "U49NHQyM": {
        "id": "U49NHQyM",
        "title": "Fundamental error bounds in state estimation: An information-theoretic analysis.",
        "abstract": "This paper investigates fundamental performance bounds on estimation error for general state estimation systems that are not necessarily linear time invariant with noises that are not necessarily white Gaussian. In the analysis, concepts from information theory such as entropy play an instrumental role. We first propose an information-theoretic notion termed Gaussianity-whiteness to measure how Gaussian and white an asymptotically stationary stochastic process is. Subsequently, we derive lower bounds on estimation error variance which can be quantified explicitly by the Gaussianity-whiteness of the noises. Furthermore, the bounds are found to be tight in the particular case of a scalar linear time-invariant system with white Gaussian noises, as verified by the benchmark given by the renowned Kalman filter.",
        "keywords": "",
        "authors": [
            {
                "name": "Song Fang",
                "org": "Department of Computer Science, Tokyo Institute of Technology"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong"
            },
            {
                "name": "Hideaki Ishii",
                "org": "Department of Computer Science, Tokyo Institute of Technology"
            }
        ],
        "venue": "CDC",
        "year": 2017
    },
    "SGTw70EL": {
        "id": "SGTw70EL",
        "title": "New time-domain algorithms for H/sub /spl infin// identification",
        "abstract": "",
        "keywords": [
            "identification",
            "computational complexity",
            "interpolation"
        ],
        "authors": [
            {
                "name": "jie chen",
                "org": "university of california"
            },
            {
                "name": "shuning wang",
                "org": ""
            }
        ],
        "venue": "advances in computing and communications",
        "year": 1995
    },
    "2rQOMEsH": {
        "id": "2rQOMEsH",
        "title": "Optimal Weight Allocation of Dynamic Distribution Networks and Positive Semi-definiteness of Signed Laplacians",
        "abstract": "In this paper, we first study a basic model of a dynamical distribution network and the corresponding the Hinf- norm. In particular, we aim to minimize the Hinf- norm subject to allocation of the weights on the edges. The optimization problem is formulated with Linear-Matrix-Inequality constraints. As closely related to the first problem, we consider the definiteness of the weighted graph Laplacian matrix with negative edge weights. A necessary and sufficient condition, using effective resistance matrix, is derived to guarantee the positive semi-definiteness of the Laplacian matrix.",
        "keywords": "",
        "authors": [
            {
                "name": "Jieqiang Wei",
                "org": ""
            },
            {
                "name": "Alexander Johansson",
                "org": ""
            },
            {
                "name": "Karl Henrik Johansson",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "arXiv: Optimization and Control",
        "year": 2018
    },
    "Bz6p2oNV": {
        "id": "Bz6p2oNV",
        "title": "Achievable performance and sensitivity integral constraints in preview control",
        "abstract": "",
        "keywords": [
            "poles and zeros",
            "trajectory",
            "sensitivity",
            "control systems",
            "robustness",
            "h",
            "stochastic processes",
            "integral equations",
            "control",
            "feedback",
            "knowledge engineering",
            "predictive control",
            "transfer functions",
            "feedback control"
        ],
        "authors": [
            {
                "name": "richard h middleton",
                "org": "newcastle university"
            },
            {
                "name": "jun chen",
                "org": ""
            },
            {
                "name": "james s freudenberg",
                "org": ""
            }
        ],
        "venue": "conference on decision and control",
        "year": 2001
    },
    "iED6g40G": {
        "id": "iED6g40G",
        "title": "Feedback stabilization of MIMO systems in the presence of stochastic network uncertainties and delays",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "tian qi",
                "org": "south china university of technology"
            },
            {
                "name": "jie chen",
                "org": "city university of hong kong"
            },
            {
                "name": "weizhou su",
                "org": "south china university of technology"
            },
            {
                "name": "minyue fu",
                "org": "university of newcastle"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "LRJc1Wk9": {
        "id": "LRJc1Wk9",
        "title": "Intrinsic limits of power reduction in MIMO networked control systems.",
        "abstract": "In this paper we develop performance bounds on disturbance power reduction for multiple-input multiple-output networked feedback systems via an information-theoretic approach. The bounds are derived for a system setting with linear time-invariant plants and causal stabilizing controllers communicating over noisy communication channels. We utilize the notion of power gain to measure the worst-case power reduction from the disturbance to the error signal. Concepts from information theory such as entropy and mutual information are instrumental in the analysis, and the performance bounds can be quantified explicitly in terms of the channel blurredness, a measure of poorness on the channel quality, and the plant unstable dynamics.",
        "keywords": "",
        "authors": [
            {
                "name": "Song Fang",
                "org": "Department of Computer Science, Tokyo Institute of Technology"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong"
            },
            {
                "name": "Hideaki Ishii",
                "org": "Department of Computer Science, Tokyo Institute of Technology"
            }
        ],
        "venue": "CDC",
        "year": 2017
    },
    "zCr9MzmS": {
        "id": "zCr9MzmS",
        "title": "Bipartite Consensus of Linear Multi-Agent Systems Over Signed Digraphs: An Output Feedback Control Approach",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "hongwei zhang",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "I2wiKFYZ": {
        "id": "I2wiKFYZ",
        "title": "Delay Margin of Low-Order Systems Achievable by PID Controllers",
        "abstract": "This paper concerns the delay margin achievable using proportional-integral-derivative (PID) controllers for linear time-invariant (LTI) systems subject to variable, unknown time delays. The basic issue under investigation addresses the question: What is the largest range of time delay so that there exists a single PID controller to stabilize the delay plants within the entire range? Delay margin is a fundamental measure of robust stabilization against uncertain time delays and poses a fundamental, longstanding problem that remains open except in simple, isolated cases. In this paper, we develop explicit expressions of the exact delay margin and its upper bounds achievable by a PID controller for low-order delay systems, notably the first- and second-order unstable systems with unknown constant and possibly time-varying delays. The effect of nonminimum phase zeros is also examined. PID controllers have been extensively used to control and regulate industrial processes that are typically modeled by first- and second-order dynamics. While furnishing the fundamental limits of delay within which a PID controller may robustly stabilize a delay process, our results should also provide useful guidelines in tuning PID parameters and in the analytical design of PID controllers.",
        "keywords": [
            "Delays",
            "Robustness",
            "Linear systems",
            "Delay effects",
            "Process control",
            "PD control",
            "Poles and zeros"
        ],
        "authors": [
            {
                "name": "Dan Ma",
                "org": "College of Information Science and Engineering, Northeastern University, Shenyang China 110004 (e-mail: madan@mail.neu.edu.cn)"
            },
            {
                "name": "Jie Chen",
                "org": "Dept. Of Electronic Engineering, City University of Hong Kong, Hong Kong China Kowloon (e-mail: jichen@cityu.edu.hk)"
            }
        ],
        "venue": "IEEE Transactions on Automatic Control",
        "year": 2018
    },
    "nJKPIhxP": {
        "id": "nJKPIhxP",
        "title": "Stability Analysis of Polynomially Dependent Systems by Eigenvalue Perturbation.",
        "abstract": "In this technical note we present a stability analysis approach for polynomially-dependent one-parameter systems. The approach, which appears to be conceptually appealing and computationally efficient and is referred to as an eigenvalue perturbation approach, seeks to characterize the analytical and asymptotic properties of eigenvalues of matrix-valued functions or operators. The essential problem dwells on the asymptotic behavior of the critical eigenvalues on the imaginary axis, that is, on how the imaginary eigenvalues may vary with respect to the varying parameter. This behavior determines whether the imaginary eigenvalues cross from one half plane into another, and hence plays a critical role in determining the stability of such systems. Our results reveal that the eigenvalue asymptotic behavior can be characterized by solving a simple generalized eigenvalue problem, leading to numerically efficient stability conditions.",
        "keywords": [
            "Eigenvalues and eigenfunctions",
            "Asymptotic stability",
            "Stability criteria",
            "Numerical stability",
            "Lyapunov methods",
            "Matrix decomposition"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Hong Kong, China"
            },
            {
                "name": "Peilin Fu",
                "org": "Department of Applied Engineering, National University, San Diego, CA, USA"
            },
            {
                "name": "C\u00e9sar-Fernando M\u00e9ndez-Barrios",
                "org": "Faculty of Engineering, Universidad Aut\u00f3noma de San Luis Potos\u00ed, San Luis Potos\u00ed, S.L.P., Mexico"
            },
            {
                "name": "Silviu-Iulian Niculescu",
                "org": "Laboratoire des Signaux et Syst\u00e8mes (L2S, UMR CNRS 8506), CNRS-Sup&#x00E9;lec, 3, Gif-sur-Yvette, France"
            },
            {
                "name": "Hongwei Zhang",
                "org": "Southwest Jiaotong University, School of Electrical Engineering, Chengdu, China"
            }
        ],
        "venue": "IEEE Trans. Automat. Contr.",
        "year": 2017
    },
    "us5K6Z8p": {
        "id": "us5K6Z8p",
        "title": "Structural Alterations in Titanate Pyrochlores Induced by Ion Irradiation: Xray Photoelectron Spectrum Interpretation",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jiqiu chen",
                "org": "university of michigan"
            },
            {
                "name": "J. Lian",
                "org": "university of michigan"
            },
            {
                "name": "L. M. Wang",
                "org": "university of michigan"
            },
            {
                "name": "rodney c ewing",
                "org": "university of michigan"
            },
            {
                "name": "J. Matt Farmer",
                "org": "oak ridge national laboratory"
            },
            {
                "name": "L. A. Boatner",
                "org": "oak ridge national laboratory"
            }
        ],
        "venue": "",
        "year": 2002
    },
    "mkKfccom": {
        "id": "mkKfccom",
        "title": "Probabilistic model validation problems with H/sub /spl infin// type uncertainties",
        "abstract": "",
        "keywords": [
            "probability",
            "gaussian noise"
        ],
        "authors": [
            {
                "name": "wenguo liu",
                "org": "university of california"
            },
            {
                "name": "jie chen",
                "org": "university of california"
            }
        ],
        "venue": "american control conference",
        "year": 2005
    },
    "SfwT4KsO": {
        "id": "SfwT4KsO",
        "title": "Model invalidation in /spl lscr//sub 1/ using frequency-domain data",
        "abstract": "In this note, we study the problem of invalidating uncertain models with an additive uncertainty. The problem is to check the existence of an uncertainty and a measurement noise which fit to the given model structure and the uncertainty/noise description, as well as the experimental data used for invalidation. We consider a mixed setting in which the uncertainty is characterized in time domain by the /spl lscr//sub 1/ induced system norm, while the available data are frequency response samples of the system. We show that this problem, which by formulation poses an infinite-dimensional primal optimization problem, can be solved in a dual, finite-dimensional space with finitely many constraints.",
        "keywords": [
            "Automatic control",
            "Educational institutions",
            "Equations",
            "Underwater vehicles",
            "Robot kinematics",
            "Robotics and automation",
            "Autonomous agents",
            "Nearest neighbor searches",
            "Animals",
            "Jacobian matrices"
        ],
        "authors": [
            {
                "name": "wenguo liu",
                "org": "university of california riverside"
            },
            {
                "name": "jie chen",
                "org": "university of california riverside"
            }
        ],
        "venue": "IEEE Transactions on Automatic Control",
        "year": 2004
    },
    "N51OVN8P": {
        "id": "N51OVN8P",
        "title": "Sign-Consensus of Linear Multi-Agent Systems Over Signed Directed Graphs.",
        "abstract": "This paper investigates sign-consensus problems of general linear multi-agent systems. The interaction between agents is modeled by a signed directed graph, where both cooperation and competition coexist within a group. The graph is allowed to be structurally unbalanced and its adjacency matrix is assumed to be eventually positive. Distributed control laws are proposed for several classes of graph topologies. Simulation examples are provided to illustrate the proposed control laws. Signed graph-based multi-agent systems provide models to opinion dynamics and social networks, and may also hold significance in further developing such internet search algorithms as PageRank to counter spamming websites.",
        "keywords": "",
        "authors": [
            {
                "name": "Ye Jiang",
                "org": "School of Electrical Engineering, Southwest Jiaotong University, Chengdu, China"
            },
            {
                "name": "Hongwei Zhang",
                "org": "School of Electrical Engineering, Southwest Jiaotong University, Chengdu, China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Kowloon, Hong Kong"
            }
        ],
        "venue": "IEEE Trans. Industrial Electronics",
        "year": 2017
    },
    "pzcVCHyw": {
        "id": "pzcVCHyw",
        "title": "Stabilization of MIMO systems over additive correlated noise channels subject to multiple SNR-constraints.",
        "abstract": "This paper studies the mean square stabilization of MIMO discrete-time linear time-invariant systems over a MIMO additive correlated channel. We assume that such channel consists of multiple correlated SISO channels subject to independent input signal-to-noise ratio (SNR) constraints. We derive explicit conditions for which mean square stabilization can be achieved under such constraints for unstable minimum phase plants, and characterize the controller that achieves such SNR. We also present the set of admissible SNR constraints for mean square stability for a particular set of plants. Our results show that noise correlation can reduce the SNR requirements for stability compared to independent additive white noise channels. In addition, a numerical simulation is provided to illustrate the theoretical results.",
        "keywords": "",
        "authors": [
            {
                "name": "Rodrigo A. Gonzalez",
                "org": ""
            },
            {
                "name": "Francisco J. Vargas",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "ECC",
        "year": 2018
    },
    "SmnEH4Dp": {
        "id": "SmnEH4Dp",
        "title": "Time domain characterizations of performance limitations of feedback control",
        "abstract": "",
        "keywords": [
            "time domain",
            "feedback control"
        ],
        "authors": [
            {
                "name": "Li Qiu",
                "org": "Hong Kong University of Science & Technology Department of Electrical & Electronic Engineering Clear Water Bay, Kowloon Hong Kong"
            },
            {
                "name": "Jie Chen",
                "org": "University of California Department of Electrical Engineering, College of Engineering 92521-0425 Riverside CA"
            }
        ],
        "venue": "",
        "year": 1999
    },
    "AGTIlNx6": {
        "id": "AGTIlNx6",
        "title": "Bounds on Delay Margin for Consensus of General Second-Order Multi-Agent Systems",
        "abstract": "This paper studies the delay margin and its bounds for second-order multi-agent systems to achieve robust consensus with respect to uncertain delays varying within a range. The issue under investigation dwells on the question: What is the largest delay range within which a distributed control protocol is able to achieve and maintain the consensus? We consider second-order agents with real unstable poles communicating over an undirected network topology, and derive bounds on the delay margin. The results show that for a strictly unstable second-order multi-agent system, its consensuability robustness depends on the pole locations of the agents, as well as on the eigen-ratio of the network graph.",
        "keywords": "",
        "authors": [
            {
                "name": "Rui Tian",
                "org": "College of Information Science and Engineering, North-eastern University, Shenyang, 110819, China"
            },
            {
                "name": "Dan Ma",
                "org": "College of Information Science and Engineering, North-eastern University, Shenyang, 110819, China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Hong Kong, China"
            }
        ],
        "venue": "world congress on intelligent control and automation",
        "year": 2018
    },
    "F1D0oXxg": {
        "id": "F1D0oXxg",
        "title": "Power Gain Bounds of MIMO Networked Control Systems: An Entropy Perspective.",
        "abstract": "In this note, we develop performance bounds on disturbance power reduction for multiple-input multiple-output networked feedback systems via an information-theoretic approach. The bounds are derived for control systems with linear time-invariant plants and causal stabilizing controllers communicating over noisy communication channels. We utilize the notion of power gain to measure the worst case power reduction from the disturbance to the error signal. Concepts from information theory, such as entropy and mutual information, are instrumental in the analysis, and the performance bounds can be quantified explicitly in terms of the channel blurredness and the plant unstable dynamics.",
        "keywords": "",
        "authors": [
            {
                "name": "Song Fang",
                "org": "Department of Computer Science, Tokyo Institute of Technology, Tokyo, Japan"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Computer Science, Tokyo Institute of Technology, Tokyo, Japan"
            },
            {
                "name": "Hideaki Ishii",
                "org": "Department of Computer Science, Tokyo Institute of Technology, Tokyo, Japan"
            }
        ],
        "venue": "IEEE Trans. Automat. Contr.",
        "year": 2019
    },
    "InzshI1E": {
        "id": "InzshI1E",
        "title": "Robust consensus of multi-agent systems with stochastic uncertain channels.",
        "abstract": "In this paper, we study the robust consensus problem of a network of general discrete-time linear agents coordinating through unreliable communication channels. Two neighboring agents exchange information via a communication channel, which is modeled in this paper as an ideal transmission system subject to a multiplicative stochastic uncertainty. This uncertain channel model includes the commonly studied logarithmic quantizers and the stochastic packet dropout as special cases. For multi-agent systems with undirected connected graphs and stochastic uncertain communication channels, we derive a sufficient condition to guarantee robust consensus in the mean square sense, which unveils the fundamental limitation posed by the synchronizability factor, the topological entropy of the agents, and the mean square channel capacity. The consensus protocol based on uncertain relative state information is then designed, using the modified algebraic Riccati equation. We also consider the case where the agents are perturbed by uncertainties in the input channels. The relations between the uncertain input and communication channel models are discussed.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhongkui Li",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Kowloon, Hong Kong"
            }
        ],
        "venue": "ACC",
        "year": 2016
    },
    "JoNDqvTa": {
        "id": "JoNDqvTa",
        "title": "Performance limitations of discrete-time systems in tracking sinusoidal signals",
        "abstract": "",
        "keywords": [
            "linear combination",
            "signal generators",
            "control systems",
            "linear systems",
            "linear time invariant system",
            "optimal control",
            "error correction",
            "factorization",
            "step response",
            "tracking",
            "signal detection",
            "adaptive control",
            "control structure"
        ],
        "authors": [
            {
                "name": "weizhou su",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "li qiu",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "jie chen",
                "org": ""
            }
        ],
        "venue": "american control conference",
        "year": 2003
    },
    "rxI2gBZ9": {
        "id": "rxI2gBZ9",
        "title": "The Caratheodory-Fejer problem and H/sub /spl infin///l/sub 1/ identification: a time domain approach",
        "abstract": "In this paper we study a worse-case, robust control oriented identification problem. This problem is in the framework of H/sub /spl infin// identification, but the formulation here is more general. The available a priori information in our problem consists of a lower bound on the relative stability of the plant, an upper bound on a certain gain associated with the plant, and an upper bound on the noise level. The plant to be identified is assumed to lie in a certain subset in the space of H/sub /spl infin//, characterized by the assumed a priori information. The available experimental information consists of a corrupt finite output time series obtained in response to a known nonzero but otherwise arbitrary input. The proposed algorithm is in the class of interpolatory algorithms which are known to possess desirable optimality properties in reducing the identification error. This algorithm is obtained by solving an extended Caratheodory-Fejer problem via standard convex programming methods. Both the algorithm and error bounds ran be applied to l/sub 1/ identification problems as well.",
        "keywords": [
            "Upper bound",
            "Frequency estimation",
            "Robust control",
            "Stability",
            "Noise level",
            "Transfer functions",
            "Control design",
            "Design methodology",
            "Time factors"
        ],
        "authors": [
            {
                "name": "jie chen",
                "org": "university of california"
            },
            {
                "name": "c n nett",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Automatic Control",
        "year": 1995
    },
    "DsbaEfrQ": {
        "id": "DsbaEfrQ",
        "title": "An alternative characterization of robust stability and stability radius for linear time delay systems",
        "abstract": "",
        "keywords": [
            "linear time",
            "linear systems",
            "stability"
        ],
        "authors": [
            {
                "name": "h sadaka",
                "org": "northeastern university"
            },
            {
                "name": "bahram shafai",
                "org": "northeastern university"
            },
            {
                "name": "rifat sipahi",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            }
        ],
        "venue": "CDC",
        "year": 2007
    },
    "NVJS432Y": {
        "id": "NVJS432Y",
        "title": "The Caratheodory-Fejer problem and H\u221e/l1 identification: a time domain approach",
        "abstract": "In this paper we study a worse-case, robust control oriented identification problem. This problem is in the framework of H\u221e identification, but the formulation here is more general. The available a priori information in our problem consists of a lower bound on the relative stability of the plant, an upper bound on a certain gain associated with the plant, and an upper bound on the noise level. The plant to be identified is assumed to lie in a certain subset in the space of H\u221e, characterized by the assumed a priori information. The available experimental information consists of a corrupt finite output time series obtained in response to a known nonzero but otherwise arbitrary input. The proposed algorithm is in the class of interpolatory algorithms which are known to possess desirable optimality properties in reducing the identification error. This algorithm is obtained by solving an extended Caratheodory-Fejer problem via standard convex programming methods. Both the algorithm and error bounds ran be applied to l1 identification problems as well",
        "keywords": [
            "H\u221e control",
            "convex programming",
            "identification",
            "interpolation",
            "optimisation",
            "robust control",
            "time series",
            "time-domain analysis",
            "Caratheodory-Fejer problem",
            "H\u221e identification",
            "convex programming",
            "corrupt finite output time series",
            "identification error",
            "interpolation",
            "l1 identification",
            "lower bound",
            "relative stability",
            "time domain",
            "upper bound",
            "worse-case robust control"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Coll. of Eng., California Univ., Riverside, CA, USA|c|"
            },
            {
                "name": "Nett, C.N.",
                "org": ""
            }
        ],
        "venue": "Automatic Control, IEEE Transactions",
        "year": 1995
    },
    "yxGAITwZ": {
        "id": "yxGAITwZ",
        "title": "Stability radius formulation of L \u03c3 -gain in positive stabilisation of regular and time-delay systems",
        "abstract": "This study initially considers the relationship between stability radius and \n<inline-formula xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><alternatives><tex-math notation=\"LaTeX\">$ L_{\\sigma }$</tex-math><mml:math overflow=\"scroll\"><mml:msub><mml:mi>L</mml:mi><mml:mrow><mml:mi>\u03c3</mml:mi></mml:mrow></mml:msub></mml:math><inline-graphic xlink:href=\"IET-CTA.2018.5296.IM2.gif\"/></alternatives></inline-formula>\n-gain of linear time-invariant positive systems. The \n<inline-formula xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><alternatives><tex-math notation=\"LaTeX\">$ L_{1}$</tex-math><mml:math overflow=\"scroll\"><mml:msub><mml:mi>L</mml:mi><mml:mrow><mml:mn>1</mml:mn></mml:mrow></mml:msub></mml:math><inline-graphic xlink:href=\"IET-CTA.2018.5296.IM3.gif\"/></alternatives></inline-formula>\n-, \n<inline-formula xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><alternatives><tex-math notation=\"LaTeX\">$L_2$</tex-math><mml:math overflow=\"scroll\"><mml:msub><mml:mi>L</mml:mi><mml:mn>2</mml:mn></mml:msub></mml:math><inline-graphic xlink:href=\"IET-CTA.2018.5296.IM4.gif\"/></alternatives></inline-formula>\n-, and \n<inline-formula xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><alternatives><tex-math notation=\"LaTeX\">$ L_{\\infty }$</tex-math><mml:math overflow=\"scroll\"><mml:msub><mml:mi>L</mml:mi><mml:mrow><mml:mi mathvariant=\"normal\">\u221e</mml:mi></mml:mrow></mml:msub></mml:math><inline-graphic xlink:href=\"IET-CTA.2018.5296.IM5.gif\"/></alternatives></inline-formula>\n-gains of an asymptotically stable positive system are characterised in terms of stability radii and useful bounds are derived. The authors show that the structured perturbation of a stable matrix can be regarded as a closed-loop system with uncertainty structure represented by the unknown static output feedback. This makes it possible to relate the \n<inline-formula xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><alternatives><tex-math notation=\"LaTeX\">$ L_{\\sigma }$</tex-math><mml:math overflow=\"scroll\"><mml:msub><mml:mi>L</mml:mi><mml:mrow><mml:mi>\u03c3</mml:mi></mml:mrow></mml:msub></mml:math><inline-graphic xlink:href=\"IET-CTA.2018.5296.IM6.gif\"/></alternatives></inline-formula>\n-gains in terms of closed-form expression available for stability radii of Metzler matrices. The authors generalise the above connection for positive-delay systems as well. Performance characterisation and computation of \n<inline-formula xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><alternatives><tex-math notation=\"LaTeX\">$ L_{\\sigma }$</tex-math><mml:math overflow=\"scroll\"><mml:msub><mml:mi>L</mml:mi><mml:mrow><mml:mi>\u03c3</mml:mi></mml:mrow></mml:msub></mml:math><inline-graphic xlink:href=\"IET-CTA.2018.5296.IM7.gif\"/></alternatives></inline-formula>\n-gains are also given based on linear programming for \n<inline-formula xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><alternatives><tex-math notation=\"LaTeX\">$\\sigma = 1, \\infty $</tex-math><mml:math overflow=\"scroll\"><mml:mi>\u03c3</mml:mi><mml:mo>=</mml:mo><mml:mn>1</mml:mn><mml:mo>,</mml:mo><mml:mi mathvariant=\"normal\">\u221e</mml:mi></mml:math><inline-graphic xlink:href=\"IET-CTA.2018.5296.IM8.gif\"/></alternatives></inline-formula>\n and linear matrix inequality (LMI) for \n<inline-formula xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><alternatives><tex-math notation=\"LaTeX\">$\\sigma = 2$</tex-math><mml:math overflow=\"scroll\"><mml:mi>\u03c3</mml:mi><mml:mo>=</mml:mo><mml:mn>2</mml:mn></mml:math><inline-graphic xlink:href=\"IET-CTA.2018.5296.IM9.gif\"/></alternatives></inline-formula>\n. The importance of this characterisation becomes evident when state feedback controllers are designed for regular and time-delay systems with positivity constraints. In particular, they show that positive stabilisation with maximum stability radius for the case of \n<inline-formula xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><alternatives><tex-math notation=\"LaTeX\">$\\sigma =2$</tex-math><mml:math overflow=\"scroll\"><mml:mi>\u03c3</mml:mi><mml:mo>=</mml:mo><mml:mn>2</mml:mn></mml:math><inline-graphic xlink:href=\"IET-CTA.2018.5296.IM10.gif\"/></alternatives></inline-formula>\n can be considered as an \n<inline-formula xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><alternatives><tex-math notation=\"LaTeX\">$L_2$</tex-math><mml:math overflow=\"scroll\"><mml:msub><mml:mi>L</mml:mi><mml:mn>2</mml:mn></mml:msub></mml:math><inline-graphic xlink:href=\"IET-CTA.2018.5296.IM11.gif\"/></alternatives></inline-formula>\n-gain minimisation, which can be solved by LMI. This inherently achieves the performance criterion and establishes a link to the reported iterative convex optimisation approaches that have been developed for the cases of \n<inline-formula xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><alternatives><tex-math notation=\"LaTeX\">$\\sigma =1$</tex-math><mml:math overflow=\"scroll\"><mml:mi>\u03c3</mml:mi><mml:mo>=</mml:mo><mml:mn>1</mml:mn></mml:math><inline-graphic xlink:href=\"IET-CTA.2018.5296.IM12.gif\"/></alternatives></inline-formula>\n and \n<inline-formula xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><alternatives><tex-math notation=\"LaTeX\">$\\sigma =\\infty $</tex-math><mml:math overflow=\"scroll\"><mml:mi>\u03c3</mml:mi><mml:mo>=</mml:mo><mml:mi mathvariant=\"normal\">\u221e</mml:mi></mml:math><inline-graphic xlink:href=\"IET-CTA.2018.5296.IM13.gif\"/></alternatives></inline-formula>\n. A significant result of this study is the derivation of bounds for \n<inline-formula xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><alternatives><tex-math notation=\"LaTeX\">$ L_{\\sigma }$</tex-math><mml:math overflow=\"scroll\"><mml:msub><mml:mi>L</mml:mi><mml:mrow><mml:mi>\u03c3</mml:mi></mml:mrow></mml:msub></mml:math><inline-graphic xlink:href=\"IET-CTA.2018.5296.IM14.gif\"/></alternatives></inline-formula>\n-gains and the unique commonality among the optimal state feedback gain matrices in obtaining \n<inline-formula xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><alternatives><tex-math notation=\"LaTeX\">$ L_{\\sigma }$</tex-math><mml:math overflow=\"scroll\"><mml:msub><mml:mi>L</mml:mi><mml:mrow><mml:mi>\u03c3</mml:mi></mml:mrow></mml:msub></mml:math><inline-graphic xlink:href=\"IET-CTA.2018.5296.IM15.gif\"/></alternatives></inline-formula>\n-gains of the stabilised system.",
        "keywords": [
            "uncertain systems",
            "linear programming",
            "state feedback",
            "control system synthesis",
            "linear systems",
            "delay systems",
            "iterative methods",
            "closed loop systems",
            "delays",
            "linear matrix inequalities",
            "continuous time systems",
            "time-varying systems",
            "convex programming",
            "asymptotic stability"
        ],
        "authors": [
            {
                "name": "Bahram Shafai",
                "org": "Northeastern University, USA"
            },
            {
                "name": "Mohammad Naghnaeian",
                "org": "Clemson University, USA"
            },
            {
                "name": "Jie Chen",
                "org": "City University of Hong Kong, Hong Kong"
            }
        ],
        "venue": "IET Control Theory & Applications",
        "year": 2019
    },
    "03hp9P9G": {
        "id": "03hp9P9G",
        "title": "On delay radii and bounds of MIMO systems.",
        "abstract": "The delay margin of a time-delay system constitutes the fundamental limit beyond which no single controller may exist to robustly stabilize an unstable delay plant for a range of delay values. For single-input single-output (SISO) systems with a linear time-invariant (LTI) controller, this margin is known to be finite for an unstable plant, and bounds on the delay margin are available. This paper extends the existing results to multi-input multi-output (MIMO) systems. We derive upper bounds on a generalized notion called delay radius. Our results show that for a delay whose direction is orthogonal to that of an unstable pole, no constraint is imposed by the pole on that delay, while if the delay direction is parallel to that of a nonminimum phase zero, its allowable range will be further restricted by the nonminimum phase zero.",
        "keywords": [
            "MIMO delay systems",
            "Delay radius",
            "Feedback stabilization"
        ],
        "authors": [
            {
                "name": "Tian Qi",
                "org": "School of Automation Science and Engineering, South China University of Technology, Guangzhou, China"
            },
            {
                "name": "Jing Zhu",
                "org": "College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Hong Kong, China"
            }
        ],
        "venue": "Automatica",
        "year": 2017
    },
    "rbih1HrV": {
        "id": "rbih1HrV",
        "title": "Worst-case system identification in H \u221e : validation of apriori information, essentially optimal algorithms, and error bounds",
        "abstract": "",
        "keywords": [
            "control systems",
            "system identification",
            "approximation algorithms",
            "interpolation",
            "frequency response",
            "noise",
            "minimization",
            "aerospace engineering",
            "upper bound",
            "stability",
            "space technology",
            "transfer functions"
        ],
        "authors": [
            {
                "name": "jie chen",
                "org": "georgia institute of technology"
            },
            {
                "name": "c n nett",
                "org": "georgia institute of technology"
            },
            {
                "name": "michael k h fan",
                "org": "georgia institute of technology"
            }
        ],
        "venue": "american control conference",
        "year": 1992
    },
    "cltZscNC": {
        "id": "cltZscNC",
        "title": "An Integral Characterization of Optimal Error Covariance by Kalman Filtering.",
        "abstract": "In this paper, we discover that the determinant of the optimal output estimation error covariance attained by the Kalman filter can be expressed explicitly in terms of the plant dynamics and noise statistics in an integral characterization. Towards this end, we examine the algebraic Riccati equation associated with Kalman filtering using analytic function theory and relate it to the Bode integral. This result may be interpreted as a generalization of the Kolmogorov\u2013Szego formula to the nonstationary case. In addition, the integral characterization is applicable to Kalman filtering with correlated noises and that with intermittent observations as well.",
        "keywords": "",
        "authors": [
            {
                "name": "Song Fang",
                "org": "Tokyo Institute of Technology, Department of Computer Science"
            },
            {
                "name": "Hideaki Ishii",
                "org": "Tokyo Institute of Technology, Department of Computer Science"
            },
            {
                "name": "Jie Chen",
                "org": "City University of Hong Kong, Department of Electronic Engineering"
            }
        ],
        "venue": "ACC",
        "year": 2018
    },
    "QFO4hG8b": {
        "id": "QFO4hG8b",
        "title": "Intrinsic performance limits of linear time-invariant feedback control",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Department of Electrical Engineering, University of California Riverside, CA 92521, USA"
            }
        ],
        "venue": "IFAC Proceedings Volumes",
        "year": 1999
    },
    "EqGqG107": {
        "id": "EqGqG107",
        "title": "Time domain validation of structured uncertainty model sets",
        "abstract": "",
        "keywords": [
            "time domain",
            "time measurement",
            "uncertainty",
            "set theory",
            "upper and lower bounds",
            "frequency domain analysis",
            "robust control",
            "computational complexity",
            "randomized algorithms",
            "model validation",
            "noise measurement",
            "hardness",
            "randomized algorithm"
        ],
        "authors": [
            {
                "name": "onur toker",
                "org": "university of california"
            },
            {
                "name": "jae chen",
                "org": ""
            }
        ],
        "venue": "conference on decision and control",
        "year": 1996
    },
    "WETyTQ50": {
        "id": "WETyTQ50",
        "title": "Worst-case system identification in H\u221e: validation of apriori information, essentially optimal algorithms, and error bounds",
        "abstract": "This paper is concerned with a particular control-oriented system identification problem recently considered by several authors. This problem has been referred to as the problem of worst-case system identification in H\u221e in the literature. The formulation of this problem is worst-case/deterministic in nature. The available apriori information consists of a lower bound on the relative stability of the plant, an upper bound on a certain gain associated with the plant, and an upper bound on the noise level. The available aposteriori information consists-of a finite number of noisy plant point frequency response samples. The objective is to identify the plant transfer function in H\u221e using the available apriori and aposteriori information. In this paper we resolve several important open issues pertaining to this problem. First, a method is presented for developing confidence that the available apriori information is correct. This method requires the solution of a certain nondifferentiable convex programming problem. Second, an essentially optimal identification algorithm is given for this problem. This algorithm is (worst-case strongy) optimal to within a factor of two. Finally, new upper and lower bounds on the optimal identification error for this problem are derived and used to estimate the identification error associated with the algorithm presented here. Interestingly, the development of each of the results described above draws heavily upon the classical Nevanlinna-Pick optimal interpolation theory. As such, the results of this paper establish a clear link between the areas of system identification and optimal interpolation theory.",
        "keywords": [],
        "authors": [
            {
                "name": "Chen, Jie",
                "org": "Postdoctoral Fellow, Schools of Aerospace and Electrical Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0250, (404) 853-0173, chen@licchus1.gatech.edu|c|"
            },
            {
                "name": "Nett, C.N.",
                "org": ""
            },
            {
                "name": "Fan, Michael K.H.",
                "org": ""
            }
        ],
        "venue": "Chicago, IL, USA",
        "year": 1992
    },
    "FEYg0rgN": {
        "id": "FEYg0rgN",
        "title": "Delay robustness of low-order systems under PID control.",
        "abstract": "This paper concerns the delay margin achievable using PID controllers for linear time-invariant (LTI) systems subject to variable, unknown time delays. The basic issue under investigation addresses the question: What is the largest range of time delay so that there exists a single PID controller to stabilize the delay plants within the entire range? Delay margin is a fundamental measure of robust stabilization against uncertain time delays and poses a fundamental, longstanding problem that remains open except in simple, isolated cases. In this paper we develop explicit expressions of the exact delay margin and its upper bounds achievable by a PID controller for low-order delay systems, notably the first- and second-order unstable systems with unknown delay. The effect of nonminimum phase zeros is also examined. Our results herein should provide useful guidelines in tuning PID controllers and in particular, the fundamental limits of delay within which a PID controller may robustly stabilize the delay processes.",
        "keywords": "",
        "authors": [
            {
                "name": "Dan Ma",
                "org": "College of Information Science and Engineering, Northeastern University, Shenyang, China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Hong Kong, China"
            }
        ],
        "venue": "CDC",
        "year": 2017
    },
    "9bSxxVl0": {
        "id": "9bSxxVl0",
        "title": "Worst-case asymptotic properties of linear algorithms for H/sub /spl infin// identification",
        "abstract": "",
        "keywords": [
            "identification",
            "frequency domain analysis"
        ],
        "authors": [
            {
                "name": "jie chen",
                "org": "university of california"
            },
            {
                "name": "guoxiang gu",
                "org": ""
            }
        ],
        "venue": "conference on decision and control",
        "year": 1999
    },
    "13dq15Gl": {
        "id": "13dq15Gl",
        "title": "Stability of systems with time-varying delays: An \u21121\u21121 small-gain perspective",
        "abstract": "An  \u2112 1  type small-gain stability analysis approach is developed in this paper on linear systems subject to time-varying delays, which reinforces the existing  \u210b \u221e  small-gain stability conditions for the same type of systems. A distinctive feature of this approach is that it requires no knowledge of delay variation rate and hence is more broadly applicable when this information is unavailable. While because of this generality the stability conditions may suffer from their conservatism, we show that there are important instances where the conditions are in fact nonconservative, and may fare better than those developed elsewhere for fast varying delays.",
        "keywords": [
            "Delay system",
            "Time-varying delay",
            "Small-gain condition",
            "stability"
        ],
        "authors": [
            {
                "name": "jing zhu",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            }
        ],
        "venue": "Automatica",
        "year": 2015
    },
    "aVEfyM0m": {
        "id": "aVEfyM0m",
        "title": "On the minimal signal recovery error in multirate filterbank channel equalization",
        "abstract": "This paper studies the constraints in filterbank design and seeks to quantify the fundamental limitations and limits inherent in this design process. The paper outlines an approach built on lifting and optimal model-matching, which attempts to quantify analytically the minimal signal recovery error in channel equalization via multirate filterbanks.",
        "keywords": [
            "channel allocation",
            "channel bank filters",
            "filtering theory",
            "signal processing",
            "filterbank design",
            "minimal signal recovery error",
            "multirate filterbank channel equalization",
            "optimal model-matching",
            "transmitters",
            "intersymbol interference",
            "signal reconstruction",
            "process design",
            "transceivers",
            "signal analysis",
            "baseband",
            "design process",
            "channel equalization",
            "filter bank"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Dept. of Electr. Eng., California Univ., Riverside, CA, USA|c|"
            }
        ],
        "venue": "SICE 2004 Annual Conference",
        "year": 2004
    },
    "6XXm7N7P": {
        "id": "6XXm7N7P",
        "title": "Best tracking and regulation performance under control energy constraint",
        "abstract": "",
        "keywords": [
            "objective function",
            "tracking",
            "indexing terms",
            "optimal control",
            "performance index"
        ],
        "authors": [
            {
                "name": "jie chen",
                "org": "university of california riverside"
            },
            {
                "name": "susumu hara",
                "org": ""
            },
            {
                "name": "gang chen",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Automatic Control",
        "year": 2003
    },
    "HeCGSr15": {
        "id": "HeCGSr15",
        "title": "Performance bounds for coprime factor controller reductions",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "kemin zhou",
                "org": "louisiana state university"
            },
            {
                "name": "jie chen",
                "org": "university of california riverside"
            }
        ],
        "venue": "Systems & Control Letters",
        "year": 1995
    },
    "md2RMb7Z": {
        "id": "md2RMb7Z",
        "title": "On delay margin bounds of discrete-time systems.",
        "abstract": "This paper studies the delay margin problem of discrete-time, linear time-invariant (LTI) systems. For general LTI plants with multiple unstable poles and nonminimum phase zeros, we employ analytic function interpolation and rational approximation techniques to derive bounds on the delay margin. Readily computable and explicit lower bounds are found by computing the real eigenvalues of a constant matrix, and LTI controllers can be synthesized based on the control theory to achieve the bounds. For first-order unstable plants, we also obtain bounds achievable by PID controllers, which are of interest to PID control design and implementation. It is worth noting that unlike its continuous-time counterpart, the discrete-time delay margin problem being considered herein constitutes a simultaneous stabilization problem, which is known to be rather difficult. While previous work on the discrete-time delay margin led to negative results, the bounds developed in this paper provide instead a guaranteed range of delays within which the delay plants can be robustly stabilized, and in turn solve the special class of simultaneous stabilization problems in question.",
        "keywords": "",
        "authors": [
            {
                "name": "Yuanye Chen",
                "org": "Department of Mechanical Engineering, University of Victoria, PO Box 3055, STN CSC, Victoria, BC, V8W 3P6, Canada"
            },
            {
                "name": "Adil Zulfiqar",
                "org": ""
            },
            {
                "name": "Dan Ma",
                "org": "Department of Mechanical Engineering, University of Victoria, PO Box 3055, STN CSC, Victoria, BC, V8W 3P6, Canada"
            },
            {
                "name": "Yang Shi",
                "org": "Department of Mechanical Engineering, University of Victoria, PO Box 3055, STN CSC, Victoria, BC, V8W 3P6, Canada"
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "CDC",
        "year": 2017
    },
    "RgAWJUmH": {
        "id": "RgAWJUmH",
        "title": "DeMOR: decentralized model order reduction of linear networks with massive ports",
        "abstract": "Model order reduction is an efficient technique to reduce the system complexity while producing a good approximation of the input-output behavior. However, the efficiency of reduction degrades as the number of ports increases, which remains a long-standing problem. The reason for the degradation is that existing approaches are based on a centralized framework, where each input-output pair is implicitly assumed to be equally interacted and the matrix-valued transfer function has to be assumed to be fully populated. In this paper, a decentralized model order reduction scheme is proposed, where a multi-input multi-output (MIMO) system is decoupled into a number of subsystems and each subsystem corresponds to one output and several dominant inputs. The decoupling process is based on the relative gain array (RGA), which measures the degree of interaction of each input-output pair. Our experimental results on a number of interconnect circuits show that most of the input-output interactions are usually insignificant, which can lead to extremely compact models even for systems with massive ports. The reduction scheme is very amenable for parallel computing as each decoupled subsystem can be reduced independently.",
        "keywords": [
            "linear network",
            "model order reduction",
            "input-output interaction",
            "reduction scheme",
            "decoupled subsystem",
            "input-output pair",
            "decentralized model order reduction",
            "massive port",
            "compact model",
            "ports increase",
            "input-output behavior",
            "reduction degrades",
            "decentralized",
            "gain",
            "transfer functions",
            "degradation",
            "signal processing",
            "input output",
            "control systems",
            "parallel computing",
            "computational modeling",
            "mimo",
            "rlc circuits"
        ],
        "authors": [
            {
                "name": "Boyuan Yan",
                "org": "University of California, Riverside, CA"
            },
            {
                "name": "Lingfei Zhou",
                "org": "University of California, Riverside, CA"
            },
            {
                "name": "Sheldon X.-D. Tan",
                "org": "University of California, Riverside, CA"
            },
            {
                "name": "Jie Chen",
                "org": "University of California, Riverside, CA"
            },
            {
                "name": "Bruce McGaughy",
                "org": "Cadence Design Systems Inc., San Jose, CA"
            }
        ],
        "venue": "DAC",
        "year": 2008
    },
    "kFqyWOkd": {
        "id": "kFqyWOkd",
        "title": "On logarithmic integrals and performance bounds for MIMO systems. I. Sensitivity integral inequalities",
        "abstract": "We extend the classical Bode integral relations to multi-input multi-output systems. Our main contributions include Bode and Poisson type integral inequalities for the sensitivity and complementary sensitivity functions, together with bounds on the sensitivity and complementary sensitivity magnitudes, which are obtained for both continuous-time and discrete-time systems. Part I presents Bode type integral inequalities. These inequalities may be viewed as some variants to the previously available results, but are also significantly different. The main difference is two fold. First, while the previous integral equalities are valid only under a restrictive assumption, the results herein hold in general. Secondly, in spite of the fact that the present results are based upon techniques and assumptions similar to those used in deriving Bode type integral inequalities, the in-depth study carried out here leads to more explicable expressions particularly indicative of the adverse effects of open loop unstable poles. As a direct outcome, the new results confirm that in a multivariable system design limitation and tradeoff depends on both the locations and directions of open loop unstable poles, and in particular, in how such directions may be aligned. The latter is characterized by angles measuring the mutual orientation between the pole directions",
        "keywords": [
            "mimo systems",
            "feedback",
            "integral equations",
            "poles and zeros",
            "sensitivity",
            "transfer function matrices",
            "poisson type integral inequalities",
            "classical bode integral relations",
            "complementary sensitivity functions",
            "logarithmic integrals",
            "multi-input multi-output systems",
            "multivariable system design limitation",
            "open loop unstable poles",
            "performance bounds",
            "sensitivity integral inequalities",
            "feedback control",
            "goniometers",
            "adverse effect",
            "open loop systems",
            "control systems",
            "mimo"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Coll. of Eng., California Univ., Riverside, CA, USA|c|"
            }
        ],
        "venue": "Decision and Control, 1997., Proceedings of the 36th IEEE Conference",
        "year": 1997
    },
    "EZdFVeMs": {
        "id": "EZdFVeMs",
        "title": "Some Remarks on the Asymptotic Behavior for Quasipolynomials with Two Delays",
        "abstract": "This paper proposes an analytical method to characterize the behavior of critical multiple roots for quasi-polynomials with two delays. The proposed approach is based on the Weierstrass polynomial, that is employed as a tool to analyze the stability behavior of such characteristic roots with respect to small variations on the delay parameters. The proposedresults are illustrated by considering a numerical example.",
        "keywords": "",
        "authors": [
            {
                "name": "A. Mart\u00ednez-Gonz\u00e1lez",
                "org": "Universidad Aut\u00f3noma de San Luis Potos\u00ed (UASLP), Facultad de Ingenier\u00eda, Dr. Manuel Nava No.8, San Luis Potos\u00ed, S.L.P., M\u00e9xico"
            },
            {
                "name": "C.F. M\u00e9ndez-Barrios",
                "org": ""
            },
            {
                "name": "Silviu-Iulian Niculescu",
                "org": "Laboratoire des Signaux et Syst\u00e8mes (L2S, UMR CNRS 8506), CNRS-Sup\u00e9lec, 3, rue Joliot Curie, 91192, Gif-sur-Yvette, France"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Electronic Engineering, City University of Hong Kong, Hong Kong, China"
            }
        ],
        "venue": "IFAC-PapersOnLine",
        "year": 2018
    },
    "2R7RN7e8": {
        "id": "2R7RN7e8",
        "title": "AAP and AAPM: Improved prefetching structures of the L2 cache",
        "abstract": "The push technique is an effective method of tolerating the Load-to-use latency. However, not every memory level can gain a sound performance improvement when the push technique is adopted. In this paper, we devise a quantitative approach to analyze workload on the bus. For balancing workload, we propose a novel architecture, which compounds the push and prefetching technique to serve different storage levels. Between the L1 and the L2 cache, we use the push technique. Between the L2 cache and memory, we utilize the prefetching technique. Focusing on the L2 cache prefetching, we propose AAP and AAPM, both of which meet the requirement of timeliness and bandwidth adaptability and can increase the IPC by 2% compared with SRP.",
        "keywords": [
            "aap",
            "aapm",
            "l2 cache",
            "prefetching",
            "quantitative approach"
        ],
        "authors": [
            {
                "name": "Qiaoshi Zheng",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            },
            {
                "name": "Deyuan Gao",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            },
            {
                "name": "Jie Chen",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            },
            {
                "name": "Chao Wang",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            }
        ],
        "venue": "ICACTE 2009 - Proceedings of the 2nd International Conference on Advanced Computer Theory and Engineering",
        "year": 2009
    },
    "DOw5Sft3": {
        "id": "DOw5Sft3",
        "title": "New method for feature extraction in ship noise",
        "abstract": "Feature extraction is the key to classification and recognition of ship noise in frequency domain. A multi-fractal theory was applied to extract fractal feature in the power spectrum of ship noise. The wavelet based multi-fractal formalism was used to compute the generalized dimension of multi-fractal measure in triadic Cantor set. The computed results agree well with theoretical values. To apply the formalism to power spectrum of ship noise, a definition of singular measure was proposed first. The singular measure was used to describe the multi-fractal features of ship noise and reflect completely the properties of target in frequency domain. The results of multi-fractal analysis for three classes of ship noise samples have shown that the multi-fractal features in power spectrum are very effective for classification.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            },
            {
                "name": "Ke'an Chen",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            },
            {
                "name": "Jincai Sun",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            }
        ],
        "venue": "Xibei Gongye Daxue Xuebao/Journal of Northwestern Polytechnical University",
        "year": 2000
    },
    "QhSQzm58": {
        "id": "QhSQzm58",
        "title": "Design of underwater acoustic transponder electronic system",
        "abstract": "The thesis introduces an Underwater Acoustic Transponder Electronic System design in positioning system,through the summary of Ultra Short Baseline Locating System's principle.The MSP430F149 is used as chip for hardware core,it is mainly used as information decoding.Transponder Electronic System consists of MCU,receiver module and transmitter module.Transponder sends answer signal after receiving the right request signal. The design philosophy and general framework of the Transponder Electronic System are represented,and the principle of circuit layout and software decoding are introduced.Critical section of system is analysed.The performance of Transponder Electronic System is proven by experiments.The request signal can be identified in minimum value of 100\u03bcV. The Transponder could work accurately in the underwater range of 2 km.",
        "keywords": [
            "Filter",
            "Positioning",
            "Respond",
            "Low power-consuming MCU MSP430"
        ],
        "authors": [
            {
                "name": "Bai Xin",
                "org": "College of Marine,Northwestern Polytechnical University,Xi'an "
            },
            {
                "name": "Qian Zhibo",
                "org": "College of Marine,Northwestern Polytechnical University,Xi'an "
            },
            {
                "name": "Chen Jie",
                "org": "College of Marine,Northwestern Polytechnical University,Xi'an "
            }
        ],
        "venue": "Electronic Measurement Technology",
        "year": 2009
    },
    "sQw3o5rz": {
        "id": "sQw3o5rz",
        "title": "Distributed wireless temperature and humidity test system based on ZigBee",
        "abstract": "The distributed wireless temperature and humidity test system was designed by using digital sensor SHT11, SCM(Single Chip Microcomputer) MSP430 and single chip transceiver ZigBee.The temperature and humidity data was acquired by SCM for processing and automatically through the ZigBee network for data transmission.Through testing,the distance of transmission indoor was about 100 meters,up to more than 1.5km outdoor.This system had a high practicality and broad area of application.",
        "keywords": [
            "wireless communication",
            "ZigBee",
            "MSP430",
            "temperature and humidity detecting"
        ],
        "authors": [
            {
                "name": "Cheng Yuewei",
                "org": "School of Marine Engineering,Northwestern Polytechnical University,Xi'an "
            },
            {
                "name": "Luo Jian",
                "org": "School of Marine Engineering,Northwestern Polytechnical University,Xi'an "
            },
            {
                "name": "Dai Shanxi",
                "org": "School of Marine Engineering,Northwestern Polytechnical University,Xi'an "
            },
            {
                "name": "Chen Jie",
                "org": "School of Marine Engineering,Northwestern Polytechnical University,Xi'an "
            }
        ],
        "venue": "Electronic Measurement Technology",
        "year": 2009
    },
    "E0w0FoPZ": {
        "id": "E0w0FoPZ",
        "title": "Tolerating memory latency: L2 cache actively push structure",
        "abstract": "Prefetching is a common technique of tolerating the memory latency. However, it rapidly increases the communications traffic between the upper-level storage and the lower-level. Based on the analysis of access patterns of the SPEC benchmarks, we propose a novel push structure, in which the L2 cache can actively push instructions and data to the L1 cache at a proper time without the request from the L1 cache. By using a cycle-accurate simulator running SPEC benchmarks, the experimenting results showed that our push structure can significantly reduce the access to the L2 cache by 34.6%. Therefore, our push structure can effectively reduce the communications traffic between the L1 and the L2 cache. Our push structure also averagely increases the IPC by 6.6%.",
        "keywords": [
            "cache",
            "miss-distance",
            "push buffer",
            "push structure"
        ],
        "authors": [
            {
                "name": "Qiaoshi Zheng",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            },
            {
                "name": "Deyuan Gao",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            },
            {
                "name": "Liwen Shi",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            },
            {
                "name": "Jie Chen",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            }
        ],
        "venue": "ICACTE 2009 - Proceedings of the 2nd International Conference on Advanced Computer Theory and Engineering",
        "year": 2009
    },
    "GsGmq7uJ": {
        "id": "GsGmq7uJ",
        "title": "Thermal diffusivity of three-dimensional needled C/SiC\u2013TaC composites",
        "abstract": "Three-dimensional needled carbon fiber reinforced SiC\u2013TaC composites were prepared by combination of slurry infiltration and reactive melt infiltration. The thermal diffusivity of the composites with different TaC contents was characterized in the temperature range from room temperature to 1400 \u00b0C. The results revealed that the temperature dependent thermal diffusivity behavior was independent on TaC content, while the thermal diffusivity values of the composites were influenced by their microstructures. A model based on lattice vibration and microstructure was used to discuss the thermal diffusivity behavior of the C/SiC\u2013TaC composites.",
        "keywords": [
            "reactive melt infiltration",
            "c/sic\u2013tac composites",
            "thermal diffusivity",
            "microstructure",
            "microstructures",
            "three dimensional",
            "room temperature"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "National Key Laboratory of Thermostructure Composite Materials, Northwestern Polytechnical University, Xi\u2019an Shanxi 710072, PR China"
            },
            {
                "name": "Yiguang Wang",
                "org": ""
            },
            {
                "name": "Laifei Cheng",
                "org": "National Key Laboratory of Thermostructure Composite Materials, Northwestern Polytechnical University, Xi\u2019an Shanxi 710072, PR China"
            },
            {
                "name": "Litong Zhang",
                "org": "National Key Laboratory of Thermostructure Composite Materials, Northwestern Polytechnical University, Xi\u2019an Shanxi 710072, PR China"
            }
        ],
        "venue": "Ceramics International",
        "year": 2011
    },
    "1PsoQj5B": {
        "id": "1PsoQj5B",
        "title": "Bootstrap SupW testing for existence of nonlinear cointegration in smooth transition vector error correction model (STVECM)",
        "abstract": "For the case of nonlinear cointegration, the STVECM model proposed by Byeongseon Seo[5] is ineffective according to Ref.6; we now propose an improved STVECM model that we believe is effective. Subsection 2.1 of the full paper adopts a SupW type test method and derives its asymptotic distribution under the null hypothesis; the core of subsection 2.1 consists of Theorems 1 and 2 with proof. Subsection 2.2, using the residual-based moving block Bootstrap method, gives the asymptotic p-values. Some simulations given in section 3 examine the finite sample performance of our method. We present numerical results in Figs. 1 and 2, which are related to the U.S. treasury yield curve rates. For the U.S. treasury yield curve rates, smooth transition cointegration relationship is actually found.",
        "keywords": [
            "Bootstrap SupW test",
            "Error correction",
            "Nonlinear cointegration",
            "U.S. treasury yield curve rate"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            },
            {
                "name": "Zheng Tian",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            },
            {
                "name": "Yingying Niu",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            },
            {
                "name": "Zheng Yang",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            }
        ],
        "venue": "Xibei Gongye Daxue Xuebao/Journal of Northwestern Polytechnical University",
        "year": 2009
    },
    "tdGeaAcU": {
        "id": "tdGeaAcU",
        "title": "The non-fragile robust H\u221e controller design with system uncertainty",
        "abstract": "This paper presents a non-fragile robust H\u221e controller design with system uncertainty. With the additive controller gain variations, the necessary and sufficient conditions for the existence of non-fragile state feedback controller are given and transformed to the LMI problems, which simplifies the solutions to get non-fragile robust H\u221e state feedback controllers. The flight control simulation results show the reliability and validity of the method. \u00a9 2013 IEEE.",
        "keywords": [
            "H\u221e control",
            "Linear Matrix Inequality (LMI)",
            "non-fragile control",
            "robust control"
        ],
        "authors": [
            {
                "name": "ChangWei Yang",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            },
            {
                "name": "Jie Chen",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            }
        ],
        "venue": "2013 25th Chinese Control and Decision Conference, CCDC 2013",
        "year": 2013
    },
    "eADbGopv": {
        "id": "eADbGopv",
        "title": "Design of Low Power Consumption Programmable Control Filter",
        "abstract": "With the wildly application of portable devices and battery-powered system,the demand of signal conditioning systems for low power consumption is rapidly increased.The New digital signal conditioning system also requires changing the signal bandwidth and cut-off frequency easily.A new scheme of low power consumption programmable control filter is designed.By using time control switched-capacitor filter chip LTC1068 and LTC1069,band-pass filter is achieved.And the master controller MSP430F5438 sets the high and low cut-off frequency.Through the test circuit,the result shows that the design can be actually used.",
        "keywords": [
            "programmable control",
            "low power consumption",
            "signal conditioning system",
            "filter"
        ],
        "authors": [
            {
                "name": "LUO Jian",
                "org": "School of Marine Engineering,Northwestern Polytechnical University,Xi'an ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Marine Engineering,Northwestern Polytechnical University,Xi'an ,China"
            },
            {
                "name": "MA Ding-kun",
                "org": "School of Marine Engineering,Northwestern Polytechnical University,Xi'an ,China"
            },
            {
                "name": "BAI Xin",
                "org": "School of Marine Engineering,Northwestern Polytechnical University,Xi'an ,China"
            }
        ],
        "venue": "Measurement & Control Technology",
        "year": 2010
    },
    "7Jazb14G": {
        "id": "7Jazb14G",
        "title": "An optimal method for AANC system within the enclosure",
        "abstract": "For the lack of an effective method to determine the optimal arrangements of secondary sources and error sensors in the adaptive active noise control (AANC) system within the enclosure, Genetic Algorithm (GA) is firstly introduced into this problem. Taking a lightly damped rectangular enclosure as an example, computer simulations have been done and the results obtained by GA coincide well with the existing rules of secondary source and error sensor arrangements within the enclosed space.",
        "keywords": [
            "Adaptive control",
            "Error sensor",
            "Genetic algorithm",
            "Noise control",
            "Optimal design"
        ],
        "authors": [
            {
                "name": "Hongwei Li",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            },
            {
                "name": "Jie Chen",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            },
            {
                "name": "Ke'an Chen",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            },
            {
                "name": "Jincai Sun",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            }
        ],
        "venue": "Zhendong Gongcheng Xuebao/Journal of Vibration Engineering",
        "year": 2001
    },
    "doF8WACH": {
        "id": "doF8WACH",
        "title": "Thermal expansion properties of 3D needled C/SiC-TaC composites",
        "abstract": "3D needled C/SiC-TaC composites were prepared by slurry infiltration combined with reactive melt infiltration (RMI). The coefficient of thermal expansion (CTE) of the composites was tested from room temperature to 1400 \u00b0C using a thermal dilatometer before and after heat treatment. The CTE value of C/SiC-TaC is higher than that of C/SiC composites. The thermal expansion behavior was qualitatively analyzed from thermal stress, preparation method and composition. The results show that the CTE of the composites increases slowly as the temperature increases at low temperature range (below 1100 \u00b0C). The increase in CTE is contributed by the thermal expansion of 90\u00b0 non-woven cloth, TaC and SiC. The fluctuations of CTE are related to the structural stress, residual silicon and asymmetrical distribution of porosities. In high temperature range (above 1100 \u00b0C), the controlling factors of thermal expansion are 0\u00b0 non-woven cloth and interfacial thermal stress. The heat-treatment resulted in the decrease in CTE values at temperatures below 1100 \u00b0C and also change the CTE behavior of the composites at temperatures higher than 1100 \u00b0C.",
        "keywords": [
            "3D needle carbon fiber",
            "C/SiC-TaC",
            "Coefficient of thermal expansion",
            "Heat-treatment",
            "Reactive melt infiltration"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            },
            {
                "name": "Yiguang Wang",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            },
            {
                "name": "Y\u00ec W\u00e1ng",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            },
            {
                "name": "Laifei Cheng",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            },
            {
                "name": "Litong Zhang",
                "org": "Northwestern Polytechnical University(Northwestern Polytechnical University,Northwestern Polytechnical Univ),Xi'an,China"
            }
        ],
        "venue": "Fuhe Cailiao Xuebao/Acta Materiae Compositae Sinica",
        "year": 2011
    },
    "AqBQjrWI": {
        "id": "AqBQjrWI",
        "title": "Potential analysis of petroleum explortation in residual basins of the China sea",
        "abstract": "The China sea area has millions square kilometers.It covers exclusive economic sone and continent self.The oil and gas exploration in the China sea is very important for sustained coordinated development strategy.The petroleum exploration in residual basins is main battlefield in \"the second round of oid and gas exploration\".This paper analyzes explorating potential from three aspects: 1) Tremendous explorating space\u2014carge sea area,large residual basins of cenozoic are pre-conogoic;2) Tremendous technical space\u2014\u2014the technology for explorating oid and Gas on the sea is obvionsly much lower than on the land.This can provide much faster prograss on sea explaration;3) Marine area has superior geology conditions.The oil and gas formations can exist not only in Cenozoic but also in pre-Cenozoic.It is expected that there is 2.1 billions workable reserve of petroleum potential.The exploration prospect is cheerful.",
        "keywords": [
            "exploration space",
            "China sea",
            "petroleum potential",
            "resources space",
            "technical space",
            "residual basin"
        ],
        "authors": [
            {
                "name": "LIU Guang-ding",
                "org": "Institute of Geology and Geophysics,Chinese academy of sciences,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Guangzhou marine geological survey,Guangzhou ,China"
            }
        ],
        "venue": "Progress In Geophysics",
        "year": 2005
    },
    "J4fvM5Dw": {
        "id": "J4fvM5Dw",
        "title": "Joint inversion of gravity-magnetic-electrical-seismic combination survey:progress and prospect",
        "abstract": "Joint inversion of explor production of Gravity-Magnetic-Electrical-Seismic survey is Integrated Geophysics interpretation method,it is integrated geophysics interpretation technique of only believable quantification at present,and it is combine application multi-geophysics information,through Inversion petrophysical property and geometric factor of geologic body get technique of one and the same underground geological and physical geography model.Text sum up development of Joint inversion technique of physical geography from the eighties of the 20th century,mostly represent a couple of side :the first to develop inversion technique at each other obligation of both parties of physical geography parameter on the basis of comprehensive applications of physical geography field.the second to advancement about joint inversion count methodological,for instance linearity inversion in contrast to nonlinearity inversion,choice of inversion means etc.sum up thought and countermeasure of Joint Inversion,put forward grow way of Joint Inversion.",
        "keywords": [
            "joint inversion",
            "obligation",
            "inversion means",
            "integrated geophysics interpretation"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Guangzhou Marine Geological Survey,Guangzhou ,China"
            },
            {
                "name": "WEN Ning",
                "org": "Guangzhou Marine Geological Survey,Guangzhou ,China"
            },
            {
                "name": "CHEN Bang-yan",
                "org": "Guangzhou Marine Geological Survey,Guangzhou ,China"
            }
        ],
        "venue": "Progress in Geophysics",
        "year": 2007
    },
    "gD3r6Cqh": {
        "id": "gD3r6Cqh",
        "title": "Gravity-magnetic response of the islands and seamounts of South China Sea",
        "abstract": "The geophysical research of seamounts and islands and other geomorphologic units of South China Sea(SCS) is of particular significance for revealing the geologic history of SCS,utilizing islands properly,solving the problem of resources shortness,constructing coastal defense and so on.But in the past,the number of lines of geophysical survey was not adequate to cover the whole SCS,and quality of these geophysical data was not as high as today because of technological limit.In recent years,new data of multibeam,gravity,magnetic and other marine geophysics with higher quality are surveyed and the lines of geophysical survey are dense around SCS.In this paper,new geophysical data of SCS by ship-survey,satellite-survey and aerial-survey from these years are integrated in order to reveal more reliable geophysical background of SCS.Here,diurnal variation data of onshore geomagnetic stations are used to calibrate the magnetic survey data in SCS.And new processing technology which has been tested in National High Technology Research and Development Program(\"863\" Program in China) is also adopted during our work.In our study,new result has been obtained for islands and seamounts from their geophysical and lithological data.That is,islands and seamounts can be divided into three kinds according to their different geophysical features and lithological properties: 1) The islands and seamounts which have high value of gravity anomaly,\u0394Z\u22a5 magnetic anomaly,density and magnetism are mainly composed of basic extrusive rocks(mainly basalt);2) The islands and seamounts which have high value of gravity anomaly and low value of \u0394Z\u22a5 magnetic anomaly are basically composed of granite and metamorphic rocks;3) The islands and seamounts which have high value of gravity anomaly and fluctuating value of \u0394Z\u22a5 magnetic anomaly which means somewhere has high value but somewhere has low value are composed of granite,metamorphic rocks mixed with volcanic eruption rock.The regular distribution of seamounts in SCS indicates that the formation of SCS is probably related to differentiation of blocks of SCS.This is the first research achievement of the comprehensive research of islands and seamounts in SCS by combining their geophysical data with lithological data.",
        "keywords": [
            "granite and metamorphic rock seamounts",
            "basic extrusive rock seamounts",
            "\u0394Z\u22a5 magnetic anomaly",
            "gravity anomaly",
            "South China Sea seabed topography"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": " Guangzhou Marine Geological Survey,Guangzhou ,China"
            },
            {
                "name": "ZHU Ben-Duo",
                "org": " Guangzhou Marine Geological Survey,Guangzhou ,China"
            },
            {
                "name": "WEN Ning",
                "org": " Guangzhou Marine Geological Survey,Guangzhou ,China"
            },
            {
                "name": "WAN Rong-Sheng",
                "org": " Guangzhou Marine Geological Survey,Guangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Geophysics",
        "year": 2012
    },
    "sQTTkRrW": {
        "id": "sQTTkRrW",
        "title": "Exploring orientation and type of structure trap in Bohai bay basin:an example of Jiyang depression",
        "abstract": "The paper proposes a new medel for the oringin of Bohai bay basin.It undergoes three stages: initial compression\u2014alternately extension and compression\u2014later period sustained splay.Under the guidance of this model authurs talke Jiyang Basin as an example to sum up its geological processes,struccture trap and the meaning of petroleum geology.Finally a favourable way of oil exploring in the basin is pointed out.",
        "keywords": [
            "extension structural",
            "negative overturn fault",
            "buried hill",
            "structural change",
            "compression structural",
            "jiyang depression"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Guangzhou Marine Geological survey,Guangzhou ,China"
            },
            {
                "name": "ZHANG Xue-cai",
                "org": "Shengli Oilfied of SINOPEC,Dongying ,China"
            }
        ],
        "venue": "Progress in Geophysics",
        "year": 2006
    },
    "lsN8DAp9": {
        "id": "lsN8DAp9",
        "title": "Construct China seas adhering to idea of scientific development",
        "abstract": "China is a great ocean state.Maritime demarcation is involved in the controversy over sovereignty,and behind the sovereignty lies the problem of resources.Having a clear picture of the basic conditions of China,we can take the initiative in international affairs and serve state economic development.Therefore,we propose the opinion of \"measure marine territory,defend state sovereignty;survey marine resources,rationally use marine,preserve the ecological environment,and prevent geological disasters\".We should adhere to idea of scientific development,make use of latest scientific techniques,make overall plans for marine enterprise,rationally exploit,use,and safeguard marine,and so as to realize sustainable and coordinated development of China seas.",
        "keywords": [
            "marine resources",
            "sovereignty",
            "idea of scientific development",
            "marine geologic disasters",
            "overall planning"
        ],
        "authors": [
            {
                "name": "LIU Guang-ding",
                "org": "Institute of Geology and Geophysics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Guangzhou Marine Geological Survey,Ministry of Land and Resources,Guangzhou ,China"
            }
        ],
        "venue": "Progress in Geophysics",
        "year": 2007
    },
    "t3JpJHak": {
        "id": "t3JpJHak",
        "title": "Application of refraction velocity in studing Mesozoic strata in Chaoshan Depression on northern margin of South China Sea",
        "abstract": "As a deposition depression mainly with the Mesozoic strata,the Chaoshan Depression is an important area for gas and oil exploration in the South China Sea.Plenty of multi-channel seismic data has been obtained in this area,but it is hard to get reflection wave velocity with enough fidelity from the stacking velocity spectrum due to strong multiple interference.Since remarkable information of refraction wave velocity could be obtained from the multi-channel seismic data of top interface of the Mesozoic strata,a program package is provided in this paper to pick up refraction seismic velocity from the multi-channel seismic data.In the experiment area,the water depth is 600\u2014800m,and the maximum offset of the survey line is 6 250m.The obtained refraction velocity of the Tertiary is 2.0-2.5 km\u00b7s-1,which is similar to the velocity of the Tertiary in the other areas of the Chaoshan Depression.The refraction velocity of the Mesozoic in the southwestern part of the Chaoshan Depression is about 3.5-4.5 km\u00b7s-1,generally lower than that of 4.0-5.0 km\u00b7s-1 in the middle and eastern parts of the Chaoshan Depression,which may imply that the reservoir property for oil and gas in the southwestern part is better.",
        "keywords": [
            "multi-channel seismic data",
            "refraction wave",
            "Chaoshan Depression",
            "Mesozoic"
        ],
        "authors": [
            {
                "name": "L\u00fc Xiu-ya",
                "org": "CAS Key Laboratory of Marginal Sea Geology,South China Sea Institute of Oceanology,CAS,Guangzhou ,China;Graduate Univ.of CAS,Beijing ,China"
            },
            {
                "name": "YAN Pin",
                "org": "CAS Key Laboratory of Marginal Sea Geology,South China Sea Institute of Oceanology,CAS,Guangzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Guangzhou Marine Geological Survey,Guangzhou ,China"
            },
            {
                "name": "ZHENG Hong-bo",
                "org": "CAS Key Laboratory of Marginal Sea Geology,South China Sea Institute of Oceanology,CAS,Guangzhou ,China;Graduate Univ.of CAS,Beijing ,China"
            },
            {
                "name": "WANG Yan-lin",
                "org": "CAS Key Laboratory of Marginal Sea Geology,South China Sea Institute of Oceanology,CAS,Guangzhou ,China;Graduate Univ.of CAS,Beijing ,China"
            }
        ],
        "venue": "Journal of Tropical Oceanography",
        "year": 2009
    },
    "wBaA6BfM": {
        "id": "wBaA6BfM",
        "title": "Potential analysis of exploration for pre-cenozoic marine residual basins in northern Yellow Sea",
        "abstract": "Analysis of petroleum geology and border geognosy in northern yellow sea,it has Proterozoic erathem for epidermis basement of northern yellow sea basin,undergoed 5 sets tectonic evolution phase,generated 4 sets regional angular unconformity interface,had multiphase hydrocarbon source rock and grouping of oilgenerating-reservoir-cap formation,possessing favorable exploration prospect.",
        "keywords": [
            "tectonic evolution",
            "northern yellow sea basin",
            "pre-cenozoic marine residual basins",
            "exploration Potential"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Guangzhou marine geological survey,Guangzhou ,China"
            }
        ],
        "venue": "Progress In Geophysics",
        "year": 2005
    },
    "vb13E6DU": {
        "id": "vb13E6DU",
        "title": "Marine Geophysical Applications in the field of National Security",
        "abstract": "Marine geophysics has a very important role in the field of national security,mainly for the coast defense and marine geological hazard warning.By the\"global,sophisticated,real-time\"monitoring of the marine geophysical environment,early detection and timely warning,protecting national security.In peacetime,it can awake national consciousness of the ocean and establish marine planning.Bulid up detailed geophysical field data and basic map of China Sea as soon as possible,and update timely,develop proprietary marine geophysical monitoring equipment,laid the marine geophysical monitoring network in coastal zone,islands and underwater,can provide a reliable basis for the decision-making in protecting national security.",
        "keywords": [
            "geophysical monitoring",
            "national security",
            "China Sea",
            "soft power"
        ],
        "authors": [
            {
                "name": "LIU Guang-ding",
                "org": "Institute of Geology and Geophysics,Chinese Academy of Sciences,Academic ian,Beij in g ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Guangzhou Marine Geological Survey,Professor,Guangzhou ,China"
            }
        ],
        "venue": "Progress in Geophysics",
        "year": 2011
    },
    "NGRp4WdX": {
        "id": "NGRp4WdX",
        "title": "Characteristics of the Geomagnetic Field in the South China Sea",
        "abstract": "It is a major task to establish objective total magnetic anomaly \u0394T and obtain credible \u0394Z_\u22a5 magnetic anomaly and Curie point isotherms.On this basis,we carry out comprehensive geological and geophysical studies of the South China Sea.It is of great significance in solving the relevant geological,geophysical and other issues resources in this region.We have has collected the measured data of the South China Sea in past years,re-processed, calibrated and integrated these date to form the total magnetic anomaly \u0394T of the South China Sea.In particular we searched the diurnal variation data of international geomagnetic stations around the South China Sea,improved \u0394T data quality greatly,and updated the total magnetic anomaly \u0394T field of the South China Sea.We have obtained vertical component of \u0394Z_\u22a5 anomalies by using all-magnetic latitude variable inclination reduction to the pole of magnetic anomaly technology.There is a very good match between \u0394Z_\u22a5 and magnetic seamounts and magnetic islands which have been confirmed,and then we established the magnetic field vertical component \u0394Z_\u22a5 field of South China Sea that can be directly used for inversion processing and interpretation.We selected the pole magnetic anomaly of wavelet multi-scale decomposition of fourth-order approximation,using a single magnetic interface inversion technology to inversion of the depth and obtained the Curie point isotherms known as the magnetic bottom interface. We have established a basic system to study and explain the magnetic field of the South China Sea,confirmed that the distribution of basalt areas of the South China Sea is correlated with the high magnetic anomalies and the regional negative magnetic anomaly area may be related to the depth of Curie point isotherms.",
        "keywords": [
            "Curie point isotherms",
            "the total magnetic anomaly AT",
            "the magnetic field vertical component \u0394Z_\u22a5",
            "the magnetic field of South China Sea"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Guangzhou Marine Geological Survey,Guangzhou ,China"
            },
            {
                "name": "GAO De-zhang",
                "org": "Institute of SINOPEC Shanghai Offshore Petroleum Branch,Shanghai ,China"
            },
            {
                "name": "WEN Ning",
                "org": "Guangzhou Marine Geological Survey,Guangzhou ,China"
            },
            {
                "name": "WAN Rong-sheng",
                "org": "Guangzhou Marine Geological Survey,Guangzhou ,China"
            }
        ],
        "venue": "Progress in Geophysics",
        "year": 2010
    },
    "egq4tGtj": {
        "id": "egq4tGtj",
        "title": "Important Marine Charting Results:the Gravity and Magnetic Anomaly Maps of South China Sea",
        "abstract": "In this paper,based on previous work,we calibrated,processed,integrated and sublimated the marine gravity and magnetic survey results of South China Sea of 1987~2007,completed the basal gravity anomaly map and magnetic anomaly \u0394T map of South China Sea.We researched the processing method of magnetic anomaly \u0394Z\u22a5,and obtained a credible magnetic anomaly \u0394Z\u22a5 map of South China Sea.Results confirmed that the gravity survey map and magnetic survey map of South China Sea match the multibeam bathymetric measurement results,the three geophysical results can verify each other,complement each other and consistent with the geophysical properties of rock got by trawl,showing that the marine charting maps of South China Sea are credible,and can be used in the basic research of the resources of South China Sea,the marine geological disaster prediction and coastal defense areas.We propose to carry out combined works formarine charting,these combined works should be the direction of development,only the marine charting results that can authenticate and complement each other is authentic,so it can be used in the basic research of the resources of South China Sea,the marine geological disaster prediction and coastal defense areas,and provide external basis for decision-making.",
        "keywords": [
            "marine charting of South China Sea",
            "the integration of gravity and magnetic measurement results",
            "the verification of geophysical field",
            "combined marine charting"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Guangzhou Marine Geological Survey,Guangzhou,Guangdong,"
            },
            {
                "name": "WEN Ning",
                "org": "Guangzhou Marine Geological Survey,Guangzhou,Guangdong,"
            },
            {
                "name": "WAN Rong-sheng",
                "org": "Guangzhou Marine Geological Survey,Guangzhou,Guangdong,"
            },
            {
                "name": "GAO De-zhang",
                "org": "Institute of SINOPEC Shanghai Offshore Petroleum Branch,Shanghai,"
            }
        ],
        "venue": "Hydrographic Surveying and Charting",
        "year": 2010
    },
    "3b5h0Lq6": {
        "id": "3b5h0Lq6",
        "title": "The status of the resource potential and petroleum exploration of The South China Sea",
        "abstract": "Due to its abundant oil and gas resource potential,the South China Sea is known as the \"Second Persian Gulf\".The strategic position of South China Sea is very important because of its diverse landforms,complicated terrain and the very special location,which is the only way connecting the countries in East Asia and Southeast Asia.Struggle the resources results in the peripheral various countries to devote themselves on the development of sea economy and the technology.From 1981 to 2002,Vietnam has mined 100 million tons oil petroleum,1.5 billion cubic metres natural gases from in the Nansha sea area oil field,making a profit of 25 billion dollars.The South China Sea petroleum has become the first big pillar Indus.The nearly half century China South China Sea oil gas prospecting work obtains the huge achievement: discovering 26 Cenozoic era basins,yielding basic petroleum geology result and laying the foundation for South China Sea's exploration development.The South China Sea has the huge exploration space and the technological development space.Each time technology advancement can bring the South China Sea oil and gas exploration the qualitative leap.",
        "keywords": [
            "perimeter state of The South China Sea",
            "exploration the status quo",
            "oil and gas resource",
            "The South China Sea"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Guangzhou Marine Geological Survey,Guangzhou ,China"
            },
            {
                "name": "WEN Ning",
                "org": "Guangzhou Marine Geological Survey,Guangzhou ,China"
            },
            {
                "name": "LI Xue-jie",
                "org": "Guangzhou Marine Geological Survey,Guangzhou ,China"
            }
        ],
        "venue": "Progress in Geophysics",
        "year": 2007
    },
    "6d4K0Sf2": {
        "id": "6d4K0Sf2",
        "title": "Several ideas on deep water oil and gas comprehensive geophysical data acquisition from marine experiments",
        "abstract": "With the development of global marine oil and gas exploration,deep water geophysical data acquisition technology has been constantly improved.Drawn upon our marine experiments,this article puts forward several ideas on deep water oil and gas geophysical data acquisition.It focuses on how to choose seismic parameters,the real time monitoring of gravity,magnetic,seismic data acquisition,and also concludes the two progresses we have made in deep water oil and gas geophysical data acquisition after the sea testing: one is 2D seismic data acquisition technology by high precision positioning long-streamer;the other is comprehensive geophysical measurement technology monitored by high accuracy gravity,magnetic and seismic joint data acquisition,which provide technical guarantee for deep water oil and gas exploration.",
        "keywords": [
            "magnetic and seismic joint data acquisition",
            "acquisition parameter",
            "quality real-time monitoring",
            "gravity",
            "2-D seismic data acquisition by high precision positioning long-streamer"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Guangzhou Marine Geological Survey,Guangzhou ,China"
            },
            {
                "name": "WEN Ning",
                "org": "Guangzhou Marine Geological Survey,Guangzhou ,China"
            },
            {
                "name": "LUO Wen-zao",
                "org": "Guangzhou Marine Geological Survey,Guangzhou ,China"
            },
            {
                "name": "GUAN Xiao-chun",
                "org": "Guangzhou Marine Geological Survey,Guangzhou ,China"
            },
            {
                "name": "WANG Gong-xiang",
                "org": "Guangzhou Marine Geological Survey,Guangzhou ,China"
            }
        ],
        "venue": "Progress in Geophysics",
        "year": 2009
    },
    "viWAKc3t": {
        "id": "viWAKc3t",
        "title": "The thoughts of the standards for offshore oil and gas investigations",
        "abstract": "The setting of the standards for offshore oil and gas geophysical surveys is very important.It is a landmark for promoting marine geophysical industrialization.The standards include some special technical requests.Firstly it should be a standard for technical matters.Secondary it should be a unified management standard for Marine geophysical data acquisition,processing and interpretation etc.It also should be a standard that can coordinate the work processes and improve the quality and efficiency in the development.To make the stardard,some attentions should be take.First,The oil and gas exploration use diffierent exploration systems beween ocean and land,so they should not be applied blindly.The collection of ocean and land geophysical equipment,collecting work methods,data processing methods are different.They belong to two different areas and should be treated differently.Through the study some advices also had been discussed in this paper.The relevant functional departments should establish standards for offshore oil and gas geophysical survey as soon as possible to ensure that offshore oil and gas investigations in an orderly manner and to protect the rights and interests of our country.",
        "keywords": [
            "marine oil and gas exploration",
            "land-based geophysics",
            "land-based oil and gas exploration",
            "marine geophysics",
            "standards for offshore oil and gas geophysical survey"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Guangzhou Marine Geological Survey,Guangzhou ,China"
            },
            {
                "name": "ZHANG Ming",
                "org": "Guangzhou Marine Geological Survey,Guangzhou ,China"
            },
            {
                "name": "CHEN Hong-wen",
                "org": "Guangzhou Marine Geological Survey,Guangzhou ,China"
            }
        ],
        "venue": "Progress in Geophysics",
        "year": 2010
    },
    "CqhhgjWy": {
        "id": "CqhhgjWy",
        "title": "Geophysical characteristics of the Chaoshan depression and its hydrocarbon exploration potential",
        "abstract": "Chaoshan depression located in the south of the Zhujiang river mouth basin,it is now becoming a new field of exploration for oil and gas of Zujiang river mouth basin.The focus of work is aim to the Mesozoic group features and hydrocarbon exploration potential at present.The text analyse region characteristic and rule of gravity and magnetism annormity in Chaoshan depression,conclusion think that the Chaoshan depression is tectonic transition belt of join two tectonic element about the dongsha islands to the xisha islands,the fault of turning towards the basin control growth of the Mesozoic group.According to characteristic and rule of seismogeology in the chaoshan depression,the thesis integrate oneself with research result by our predecessors,put forward hydrocarbon exploration potential in Chaoshan depression.",
        "keywords": [
            "regional geophysics",
            "seismogeology",
            "hydrocarbon exploration potential",
            "Chaoshan depression"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Guangzhou marine geological survey,Guangzhou ,China"
            }
        ],
        "venue": "Progress in Geophysics",
        "year": 2007
    },
    "Ede9z2p1": {
        "id": "Ede9z2p1",
        "title": "Freedom and Ethical Restriction of Innovative Research in Modern Medicine",
        "abstract": "With the rapid development of life sciences,the conflict between ethics and the freedom of innovative medical research have become more and more obvious.This paper introduces the nature of medical research and its specific feature of service,clarifies that humanities and medical ethics are the norms of social liberation,the social normative feature of ethical principle,the mutual relationship of ethics and innovative medical research,and the role of ethical principles in medical research,aiming at a brighter development of innovative medical research under the guidance of modern medical ethical principles.",
        "keywords": [
            "Innovative Medical Research",
            "Medical Ethics",
            "Medical Research",
            "Modern Medicine",
            "Ethical Restriction"
        ],
        "authors": [
            {
                "name": "HUANG Hui",
                "org": "Sun Yat-sen Memorial Hospital of Sun Yat-sen University,Guangzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Sun Yat-sen Memorial Hospital of Sun Yat-sen University,Guangzhou ,China"
            },
            {
                "name": "ZOU Yan-qin",
                "org": "Sun Yat-sen Memorial Hospital of Sun Yat-sen University,Guangzhou ,China"
            },
            {
                "name": "WANG Jing-feng",
                "org": "Sun Yat-sen Memorial Hospital of Sun Yat-sen University,Guangzhou ,China"
            }
        ],
        "venue": "Chinese Medical Ethics",
        "year": 2010
    },
    "lrIqX8RJ": {
        "id": "lrIqX8RJ",
        "title": "Combination with anthropometric measurements and MQSGA to assess nutritional status in Chinese he-modialysis population",
        "abstract": "Aims: To assess the nutritional status, combination with anthropometric measurements and modified quantitative subjective global assessment (MQSGA) was used in multi-center hemodialysis population in South China. Methods: A cross-sectional, descriptive-analytic study was performed in 4 teaching hospitals in South China, dated from January 2010 to December 2011. Nutritional status was assessed with MQSGA and related anthropometric indexes. Serum albumin and transthyretin were also determined for nutritional assessment. Results: Eighty-two randomly selected hemodialysis patients participated in the nutritional assessment, of which 75 hemodialysis patients completed all assessments. The average age was 62.70 \u00b1 14.21 years. The mean duration of hemodialysis was 3.29 \u00b1 1.08 years. Of the included patients, 32% patients were well nourished, 60% were mild to moderately malnourished, and 8% were severely malnourished. Along with the malnutrition severity, the serum transthyretin significantly decreased. However, no obvious changes were found in serum albumin. The mean value (Mean \u00b1 SD; 25.78 \u00b1 4.09 cm) of mid arm circumference (MAC) was negatively correlated with MQSGA (r = -0.365; P = 0.002). Body mass index (BMI) (Mean \u00b1 SD; 21.6 \u00b1 3.1 kg/m2) was also significantly negatively correlated with MQSGA (r = -0.392; P = 0.001). The areas under the receiver operating characteristic curve were 0.664 and 0.726, respectively. Conclusions: Malnutrition is very common in South China hemodialysis population. Both BMI and MAC were effective markers for assessing nutritional status. \u00a9 Ivyspring International Publisher.",
        "keywords": [
            "Anthropometric measurements",
            "Hemodialysis",
            "Modified quantitative subjective global assessment",
            "Nutrition"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology(Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology),Guangzhou,China"
            },
            {
                "name": "Hongquan Peng",
                "org": "Kiang Wu Hospital(Kiang Wu Hospital),Hong Kong,China"
            },
            {
                "name": "Zhimin Yuan",
                "org": "Sun Yat-Sen University(Zhongshan University,Sun Yat-Sen University,Sun Yat-sen University),Guangzhou,China"
            },
            {
                "name": "Kun Zhang",
                "org": "Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology(Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology),Guangzhou,China"
            },
            {
                "name": "Long Xiao",
                "org": "Guangzhou Medical College(Guangzhou Medical College),Guangzhou,China"
            },
            {
                "name": "Jialian Huang",
                "org": "First Affiliated Hospital of Guangdong Pharmaceutical University(First affiliated hospital of Guang Dong Pharmaceutical University,The First Affiliated Hospital of Guangdong Pharmaceutical University,The First Affiliated Hospital of Guangdong Hospital University of Pharmacy,First Affiliated Hospital of Guangdong Pharmaceutical University),Guangzhou,China"
            },
            {
                "name": "Jingfeng Wang",
                "org": "Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology(Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology),Guangzhou,China"
            },
            {
                "name": "Hui Huang",
                "org": "Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology(Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology),Guangzhou,China"
            }
        ],
        "venue": "International Journal of Medical Sciences",
        "year": 2013
    },
    "6hxXOntr": {
        "id": "6hxXOntr",
        "title": "Cigarette smoking reduced renal function deterioration in hypertensive patients may be mediated by elevated homocysteine.",
        "abstract": "Elevated homocysteine (HCY) and smoking are both important risk factors for hypertensive patients. However, whether they have crossing effect on renal function deterioration of hypertensive patients and what is the underlying mechanism are unclear. In the present study, 3033 participants diagnosed as essential hypertension with estimated glomerular filtration rate (eGFR)> 30 ml/min/1.73 m2 from southern China were enrolled in this cross-sectional study. We collected the demographic and clinical data. In addition, the mediation effects were analyzed. The results showed that, comparing with non-smokers, smokers had significant higher levels of HCY (13.10 (11.20-16.87) vs. 11.00 (8.90-13.40) umol/L, P < 0.001) and lower eGFR (79.71 (66.83-91.05) vs. 82.89 (69.80-95.85) ml/min/1.73m2, P < 0.001). HCY levels and smoking were independently associated with decreased eGFR. Meanwhile, eGFR levels were significantly negatively correlated with HCY (P < 0.001), and this correlation might be stronger in current smokers. Current smoker consuming over 20 cigarettes per day would accelerate early renal function deterioration (OR = 1.859, P = 0.019). The mediation effects analysis further showed that the association between smoking and renal function deterioration was mediated by HCY. And elevated HCY was accounted for 56.94% of the estimated causal effect of smoking on renal function deterioration in hypertensive patients. Our findings indicated that cigarette smoking was associated with renal function deterioration in hypertensive patients, and the association between cigarette smoking and renal function deterioration was probably mediated by elevated HCY. Therefore, HCY-lowering therapy may be beneficial for renal function deterioration in hypertensive smoking patients.",
        "keywords": [
            "cigarette smoking",
            "homocysteine",
            "hypertension",
            "renal function deterioration"
        ],
        "authors": [
            {
                "name": "Feifei Huang",
                "org": "Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Radiation Oncology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Xun Liu",
                "org": "Division of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China."
            },
            {
                "name": "Feng Han",
                "org": "Department of Ultrasound, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Guangzhou, China."
            },
            {
                "name": "Qingqing Cai",
                "org": "Department of Medical Oncology, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou, China."
            },
            {
                "name": "Guicheng Peng",
                "org": "Department of Internal Medicine, Dongguan Hengli Hospital, Dongguan, China."
            },
            {
                "name": "Kun Zhang",
                "org": "Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China."
            },
            {
                "name": "Weiqing Chen",
                "org": "Department of Biostatistics and Epidemiology, School of Public Health, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Jingfeng Wang",
                "org": "Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China."
            },
            {
                "name": "Hui Huang",
                "org": "Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China."
            }
        ],
        "venue": "Oncotarget",
        "year": 2016
    },
    "NxauSsnk": {
        "id": "NxauSsnk",
        "title": "Advanced oxidation protein products aggravate cardiac remodeling via cardiomyocyte apoptosis in chronic kidney disease.",
        "abstract": "Advanced oxidation protein products (AOPPs) are independent risk factor for various cardiovascular diseases. Cardiomyocyte apoptosis has been implicated as an important mechanism in cardiac remodeling in chronic kidney disease (CKD). However, whether AOPPs affect cardiomyocyte apoptosis and subsequent cardiac remodeling in CKD is still not very clear. Here, we assessed the role of AOPPs in cardiomyocyte apoptosis in CKD. H9C2 rat cardiomyoblast cells were exposed to AOPPs. The apoptotic cells were determined by TUNEL assay. The expression of apoptotic markers (cleaved caspase-3 and Bax), JNK signaling and endoplasmic reticulum stress were explored. Serum AOPPs were measured in male Sprague-Dawley rats underwent sham surgery and 5/6 nephrectomy respectively. In vitro, our findings showed that AOPPs activated JNK signaling and endoplasmic reticulum stress, and significantly aggravated H9C2 rat cardiomyoblast cells apoptosis. These effects were partially ameliorated by apocynin with inhibition of oxidative stress. In vivo, serum levels of AOPPs were progressively elevated with the increasing time course in CKD rats as compared with sham-operated rats (P<0.05). Serum AOPPs levels were positively associated with cardiomyocyte apoptosis (R2= 0.76, P<0.01). In conclusion, AOPPs aggravate cardiomyocyte apoptosis in vitro, and these effects are partially prevented by apocynin via suppressing JNK signaling and endoplasmic reticulum stress with oxidative stress inhibition. In vivo, AOPPs are increased in CKD model and may contribute to the cardiac pathogenesis but at this point it is unclear if that is true. These results suggest that pharmacological approaches to attenuate AOPPs-aggravated cardiomyocytes apoptosis may be beneficial to improve cardiac remodeling in CKD.",
        "keywords": [
            "advanced oxidation protein products",
            "cardiac remodeling",
            "cardiomyocyte apoptosis",
            "chronic kidney disease"
        ],
        "authors": [
            {
                "name": "Weijing Feng",
                "org": "Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Kun Zhang",
                "org": "Sun Yat-sen Memorial Hospital of Sun Yat-sen University; Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology."
            },
            {
                "name": "Yu Liu",
                "org": "Sun Yat-sen Memorial Hospital of Sun Yat-sen University; Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology."
            },
            {
                "name": "Jie Chen",
                "org": "Sun Yat-sen Memorial Hospital of Sun Yat-sen University."
            },
            {
                "name": "Qingqing Cai",
                "org": "Department of Medical Oncology, Sun Yat-sen University Cancer Center, Sun Yat-sen University."
            },
            {
                "name": "Wanbing He",
                "org": "Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University."
            },
            {
                "name": "Yinyin Zhang",
                "org": "Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Mong-Heng Wang",
                "org": "Augusta University."
            },
            {
                "name": "Jingfeng Wang",
                "org": "Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Hui Huang",
                "org": "Sun Yat-sen Memorial Hospital of Sun Yat-sen University huanghui765@hotmail.com."
            }
        ],
        "venue": "American journal of physiology. Heart and circulatory physiology",
        "year": 2017
    },
    "m81qn9w4": {
        "id": "m81qn9w4",
        "title": "Roles of aldosterone in vascular calcification: An update",
        "abstract": "Abstract   Both clinical and experimental studies have demonstrated that vascular calcification (VC) is a common pathology shared in many chronic diseases such as chronic kidney disease (CKD) and diabetes. Itu0027s an independent risk factor for cardiovascular events. Since the pathogenesis of VC is complicated, current therapies have limited effects on the regression of VC. Therefore, it is urgent to investigate the potential mechanisms and find new targets for the treatment of VC. Aldosterone (Aldo), a mineralocorticoid hormone, is the metabolite of renin-angiotensin-aldosterone system (RAAS) activation, which can exert genomic and non-genomic effects on the cardiovascular system. Recent data suggests that Aldo can promote VC. Here, we summarized the roles of Aldo in the process of VC and a series of findings indicated that Aldo could act as a potentially therapeutic target for treating VC.",
        "keywords": "",
        "authors": [
            {
                "name": "Jingwei Gao",
                "org": "Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120 China"
            },
            {
                "name": "Kun Zhang",
                "org": "Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120 China"
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Mong Heng Wang",
                "org": "Department of Physiology, Georgia Regents University, Augusta, GA 30912, United States"
            },
            {
                "name": "Jingfeng Wang",
                "org": "Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120 China"
            },
            {
                "name": "Pinming Liu",
                "org": "Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120 China"
            },
            {
                "name": "Hui Huang",
                "org": "Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120 China"
            }
        ],
        "venue": "European Journal of Pharmacology",
        "year": 2016
    },
    "L6lG3EsB": {
        "id": "L6lG3EsB",
        "title": "Interleukin-18 Enhances Vascular Calcification and Osteogenic Differentiation of Vascular Smooth Muscle Cells Through TRPM7 Activation",
        "abstract": "Objective\u2014  Vascular calcification (VC) is an important predictor of cardiovascular morbidity and mortality. Osteogenic differentiation of vascular smooth muscle cells (VSMCs) is a key mechanism of VC. Recent studies show that IL-18 (interleukin-18) favors VC while TRPM7 (transient receptor potential melastatin 7) channel upregulation inhibits VC. However, the relationship between IL-18 and TRPM7 is unclear. We questioned whether IL-18 enhances VC and osteogenic differentiation of VSMCs through TRPM7 channel activation.  Approach and Results\u2014  Coronary artery calcification and serum IL-18 were measured in patients by computed tomographic scanning and enzyme-linked immunosorbent assay, respectively. Primary rat VSMCs calcification were induced by high inorganic phosphate and exposed to IL-18. VSMCs were also treated with TRPM7 antagonist 2-aminoethoxy-diphenylborate or TRPM7 small interfering RNA to block TRPM7 channel activity and expression. TRPM7 currents were recorded by patch-clamp. Human studies showed that serum IL-18 levels were positively associated with coronary artery calcium scores ( r =0.91;  P  P   Conclusions\u2014  These findings suggest that coronary artery calcification is associated with increased IL-18 levels. IL-18 enhances VSMCs osteogenic differentiation and subsequent VC induced by \u03b2-glycerophosphate via TRPM7 channel activation. Accordingly, IL-18 may contribute to VC in proinflammatory conditions.",
        "keywords": "",
        "authors": [
            {
                "name": "Kun Zhang",
                "org": ""
            },
            {
                "name": "Yinyin Zhang",
                "org": ""
            },
            {
                "name": "Weijing Feng",
                "org": ""
            },
            {
                "name": "Renhua Chen",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Rhian M. Touyz",
                "org": ""
            },
            {
                "name": "Jingfeng Wang",
                "org": ""
            },
            {
                "name": "Hui Huang",
                "org": ""
            }
        ],
        "venue": "Arteriosclerosis, Thrombosis, and Vascular Biology",
        "year": 2017
    },
    "kYiDpwfK": {
        "id": "kYiDpwfK",
        "title": "Shexiang Baoxin pills promotes angiogenesis in myocardial infarction rats via up-regulation of 20-HETE-mediated endothelial progenitor cells mobilization.",
        "abstract": "Therapeutic angiogenesis is a pivotal strategy for ischemic heart disease. The aim of the present study was to determine the effect and molecular mechanism of Shexiang Baoxin pills, a widely-used traditional Chinese medicine for ischemic heart disease, on angiogenesis in a rat model of myocardial infarction (MI).We used the occlusion of left anterior descending coronary artery of Sprague-Dawley rats as a model of MI. The MI rats were treated with distilled water, Shexiang Baoxin pills, or Shexiang Baoxin pills + HET0016 (a selective blocker of the biosynthesis of 20-hydroxyeicosatetraenoic acid (20-HETE) at 10 mg/kg/day), respectively. Sham-operated rats were used as controls.Treatment with Shexiang Baoxin pills increases the level of serum 20-HETE in MI rats, which can be suppressed by HET0016 treatment. Shexiang Baoxin pills shows cardio-protective effects on MI rats, including improving cardiac function, decreasing infarction area, and promoting angiogenesis in peri-infarct area. The protective effects of Shexiang Baoxin pills are partly inhibited by HET0016. Furthermore, Shexiang Baoxin pills enhances the number of circulating endothelial progenitor cells (EPCs) and the expression of the vascular endothelial growth factor (VEGF), based on immunohistochemical analysis, in peri-infarct area of MI rats, which is partly suppressed by HET0016.Shexiang Baoxin pills may partially participate in angiogenesis in MI rats. The protective mechanism of Shexiang Baoxin pills may be mediated via up-regulation of 20-HETE, which promotes EPCs mobilization and VEGF expression.",
        "keywords": [
            "20-HETE",
            "Angiogenesis",
            "Endothelial progenitor cells",
            "Myocardial infarction",
            "Shexiang Baoxin pills",
            "Vascular endothelial growth factor"
        ],
        "authors": [
            {
                "name": "Feifei Huang",
                "org": "Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China."
            },
            {
                "name": "Yang Liu",
                "org": "Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China; Department of Cardiology, The Second Affiliated Hospital of University of South China, Hengyang, China."
            },
            {
                "name": "Xia Yang",
                "org": "Department of Biochemistry, Zhongshan School of Medicine, SunYat-sen University, Guangzhou, China; Key Laboratory of Functional Molecules from Marine Microorganisms (Sun Yat-sen University), Department of Education of Guangdong Province, Guangzhou, China."
            },
            {
                "name": "Di Che",
                "org": "Key Laboratory of Functional Molecules from Marine Microorganisms (Sun Yat-sen University), Department of Education of Guangdong Province, Guangzhou, China; Program of Molecular Medicine, Affiliated Guangzhou Women and Children's Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Kaifeng Qiu",
                "org": "Department of Pharmacy, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China."
            },
            {
                "name": "Bruce D Hammock",
                "org": "Department of Entomology and Nematology and UC Davis Comprehensive Cancer Research Center, University of California, Davis, USA."
            },
            {
                "name": "Jingfeng Wang",
                "org": "Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China."
            },
            {
                "name": "Mong-Heng Wang",
                "org": "Department of Physiology, Augusta University, Augusta, GA 30912, USA."
            },
            {
                "name": "Jie Chen",
                "org": "Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China; Department of Radiation Oncology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China."
            },
            {
                "name": "Hui Huang",
                "org": "Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China; Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China."
            }
        ],
        "venue": "Atherosclerosis",
        "year": 2017
    },
    "PFDeKaIA": {
        "id": "PFDeKaIA",
        "title": "Mechanisms of epoxyeicosatrienoic acids to improve cardiac remodeling in chronic renal failure disease.",
        "abstract": "Both clinical and basic science studies have demonstrated that cardiac remodeling in patients with chronic renal failure (CRF) is very common. It is a key feature during the course of heart failure and an important risk factor for subsequent cardiac mortality. Traditional drugs or therapies rarely have effects on cardiac regression of CRF and cardiovascular events are still the first cause of death. Epoxyeicosatrienoic acids (EETs) are the products of arachidonic acids metabolized by cytochrome P450 epoxygenases. It has been found that EETs have important biological effects including anti-hypertension and anti-inflammation. Recent data suggest that EETs are involved in regulating cardiomyocyte injury, renal dysfunction, chronic kidney disease (CKD)-related risk factors and signaling pathways, all of which play key roles in cardiac remodeling induced by CRF. This review analyzes the literature to identify the possible mechanisms for EETs to improve cardiac remodeling induced by CRF and indicates the therapeutic potential of EETs in it.",
        "keywords": [
            "signaling pathway",
            "renal function"
        ],
        "authors": [
            {
                "name": "Kun Zhang",
                "org": "Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China."
            },
            {
                "name": "Ju Wang",
                "org": ""
            },
            {
                "name": "Huanji Zhang",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Zhiyi Zuo",
                "org": ""
            },
            {
                "name": "Jingfeng Wang",
                "org": ""
            },
            {
                "name": "Hui Huang",
                "org": ""
            }
        ],
        "venue": "European journal of pharmacology",
        "year": 2013
    },
    "5wXVg2eq": {
        "id": "5wXVg2eq",
        "title": "The Effect of Prophylactic Lamivudine plus Adefovir Therapy Compared with Lamivudine Alone in Preventing Hepatitis B Reactivation in Lymphoma Patients with High Baseline HBV DNA during Chemotherapy.",
        "abstract": "Prophylactic antiviral therapy is essential for lymphoma patients with high baseline HBV DNA who undergo cytotoxic chemotherapy. However, there are limited data on the optimal options. The present study was designed to compare the efficacy of prophylactic lamivudine (LAM) with lamivudine plus adefovir dipivoxil (LAM+ADV) in preventing hepatitis B virus (HBV) reactivation in lymphoma with, pre-chemotherapy HBV DNA load \u22652000 IU/ml. We retrospectively analyzed the medical records of 86 lymphoma patients with baseline HBV DNA load \u22652000 IU/ml during chemotherapy and received LAM or LAM+ADV as prophylaxis between January 1, 2008 and November 30, 2014 at Sun Yat-sen University Cancer Center, China. Sixty-five patients received LAM and 21 received LAM+ADV. The rate was significantly lower in the LAM+ADV group compared with the LAM group for HBV reactivation (23.8% vs 55.4%; p = 0.012), while no difference was observed between the two groups in patients for HBV-related hepatitis (21.3% vs 33.3%; p \u2009 = \u20090.349), and chemotherapy disruption (10.9% vs 19.0%; p = 0.337). In a multivariate analysis of factors associated with HBV reactivation in these patients, LAM+ADV treatment and HBeAg negative were the independent protective factors. Therefore, LAM+ADV should be considered for antiviral prophylaxis in lymphoma patients with pre-chemotherapy HBV DNA load \u22652000 IU/ml. Further study is warranted to confirm these findings.",
        "keywords": "",
        "authors": [
            {
                "name": "Qingqing Cai",
                "org": "Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, P.R. China."
            },
            {
                "name": "Kailin Chen",
                "org": "Department of Oncology, Hunan Provincial People's Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha, P.R. China."
            },
            {
                "name": "Jie Chen",
                "org": "Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology, Guangzhou, China, and Radiotherapy Department, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, P.R. China."
            },
            {
                "name": "Shaoxu Wu",
                "org": "Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, P.R. China."
            },
            {
                "name": "Qirong Geng",
                "org": "Department of hematology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, P.R. China."
            },
            {
                "name": "Huiqiang Huang",
                "org": "Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, P.R. China."
            },
            {
                "name": "Tongyu Lin",
                "org": "Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, P.R. China."
            },
            {
                "name": "Wenqi Jiang",
                "org": "Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, P.R. China."
            },
            {
                "name": "Zhongjun Xia",
                "org": "Department of hematology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, P.R. China."
            },
            {
                "name": "Huaxin Duan",
                "org": "Department of Oncology, Hunan Provincial People's Hospital, the First Affiliated Hospital of Hunan Normal University, Changsha, P.R. China."
            },
            {
                "name": "Huilan Rao",
                "org": "Department of Pathology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, P.R. China."
            },
            {
                "name": "Mengfei Yao",
                "org": "Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, P.R. China."
            },
            {
                "name": "Liyang Hu",
                "org": "Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, P.R. China."
            }
        ],
        "venue": "PloS one",
        "year": 2016
    },
    "sSlA0SKe": {
        "id": "sSlA0SKe",
        "title": "MICS, an easily ignored contributor to arterial calcification in CKD patients",
        "abstract": "In chronic kidney disease (CKD), simultaneous mineral and skeleton changes are prevalent, known as CKD-mineral bone disorder (CKD-MBD). Arterial calcification (AC) is a clinically important complication of CKD-MBD. It can increase arterial stiffness, which leads to severe cardiovascular events. However, current treatments have little effect on regression of AC, as its mechanisms are still unclear. There are multiple risk factors of AC, among which Malnutrition-Inflammation Complex Syndrome (MICS) is a new and crucial one. MICS, a combined syndrome of malnutrition and inflammation, generally begins at the early stage of CKD and becomes obvious in end-stage renal disease (ESRD). It was linked to reverse epidemiology and associated with increased cardiovascular mortality in ESRD patients. Recent data suggest that MICS can trigger CKD-MBD and accelerate the course of AC. In this present review, we summarize the recent understanding about the aggravating effects of MICS on AC and discuss the possible underlyin...",
        "keywords": "",
        "authors": [
            {
                "name": "Kun Zhang",
                "org": "1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China;"
            },
            {
                "name": "Jingwei Gao",
                "org": "1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China;"
            },
            {
                "name": "Jie Chen",
                "org": "2Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology, Guangzhou, China;"
            },
            {
                "name": "Xun Liu",
                "org": "4Division of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; and"
            },
            {
                "name": "Qingqing Cai",
                "org": "5Department of Medical Oncology, Sun Yat-sen University Cancer Center, SunYat-sen University, Guangzhou, China"
            },
            {
                "name": "Pinming Liu",
                "org": "1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China;"
            },
            {
                "name": "Hui Huang",
                "org": "1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China;"
            }
        ],
        "venue": "American Journal of Physiology-renal Physiology",
        "year": 2016
    },
    "Fo1BMoos": {
        "id": "Fo1BMoos",
        "title": "The Emerging Role of Mesenchymal Stem Cells in Vascular Calcification",
        "abstract": "Vascular calcification (VC), characterized by hydroxyapatite crystal depositing in the vessel wall, is a common pathological condition shared by many chronic diseases and an independent risk factor for cardiovascular events. Recently, VC is regarded as an active, dynamic cell-mediated process, during which calcifying cell transition is critical. Mesenchymal stem cells (MSCs), with a multidirectional differentiation ability and great potential for clinical application, play a duplex role in the VC process. MSCs facilitate VC mainly through osteogenic transformation and apoptosis. Meanwhile, several studies have reported the protective role of MSCs. Anti-inflammation, blockade of the BMP2 signal, downregulation of the Wnt signal, and antiapoptosis through paracrine signaling are possible mechanisms. This review displays the evidence both on the facilitating role and on the protective role of MSCs, then discusses the key factors determining this divergence.",
        "keywords": "",
        "authors": [
            {
                "name": "Changming Xie",
                "org": "Department of Cardiology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518000, China"
            },
            {
                "name": "Liu Ouyang",
                "org": "Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Radiation Oncology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China"
            },
            {
                "name": "Huanji Zhang",
                "org": "Department of Cardiology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518000, China"
            },
            {
                "name": "Pei Luo",
                "org": "State Key Laboratory for Quality Research of Chinese Medicines, Macau University of Science and Technology, Taipa 999078, Macau"
            },
            {
                "name": "Jingfeng Wang",
                "org": "Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China"
            },
            {
                "name": "Hui Huang",
                "org": "Department of Cardiology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518000, China"
            }
        ],
        "venue": "Stem Cells International",
        "year": 2019
    },
    "tC2OY8rk": {
        "id": "tC2OY8rk",
        "title": "GW28-e0959 Advanced oxidation protein products exacerbates cardiac remodeling via cardiomyocyte apoptosis in chronic kidney disease",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Weijing Feng",
                "org": "Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"
            },
            {
                "name": "Wanbing He",
                "org": "Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"
            },
            {
                "name": "Yinyin Zhang",
                "org": "Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"
            },
            {
                "name": "Mong Heng Wang",
                "org": "Department of Physiology, Augusta University, Augusta, GA, USA"
            },
            {
                "name": "Jingfeng Wang",
                "org": ""
            },
            {
                "name": "Kun Zhang",
                "org": "Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"
            },
            {
                "name": "Yu Liu",
                "org": "Department of Cardiology, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China"
            },
            {
                "name": "Jie Chen",
                "org": "Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"
            },
            {
                "name": "Qingqing Cai",
                "org": "Department of Medical Oncology, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou, China"
            },
            {
                "name": "Hui Huang",
                "org": "Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China"
            }
        ],
        "venue": "Journal of the American College of Cardiology",
        "year": 2017
    },
    "I4ir937H": {
        "id": "I4ir937H",
        "title": "Low Response of Renin-Angiotensin System to Sodium Intake Intervention in Chinese Hypertensive Patients.",
        "abstract": "The interactions of sodium balance and response of renin\u2013angiotensin\u2013aldosterone system are important for maintaining the hemodynamic stability in physiological conditions. However, the influence of short-term sodium intake intervention in the response of renin\u2013angiotensin system (RAS) on hypertensive patients is still unclear. Thus, we conducted a clinical trial to investigate the effects of short-term sodium intake intervention on the response of RAS in hypertensive patients.One hundred twenty-five primary Chinese hypertensive patients were divided into high, moderate, and low sodium groups by 24-hour urinary sodium excretion (UNa+). All the patients received a 10-day dietary sodium intake intervention with standardized sodium (173.91mmol/day) and potassium (61.53mmol/day). Blood pressure, urinary sodium, urinary potassium, plasma sodium, potassium, creatinine, the levels of plasma renin activity, plasma angiotensin II concentrations (AT-II), and plasma aldosterone concentrations were detected before and after the intervention.Before the intervention, no differences were found in blood pressure and RAS among 3 groups. After standardized dietary sodium intake intervention, both UNa+ excretion and systolic pressure decreased in high-sodium group, while they increased in moderate and low-sodium groups. Intriguingly, there were no changes in the levels of plasma renin activity, AT-II, and plasma aldosterone concentrations among 3 groups during the intervention.The present study demonstrated that the influenced sodium excretion and blood pressure by short-term sodium intake intervention were independent of RAS quick response in Chinese hypertensive patients.",
        "keywords": "",
        "authors": [
            {
                "name": "Weijing Feng",
                "org": ""
            },
            {
                "name": "Qingqing Cai",
                "org": ""
            },
            {
                "name": "Woliang Yuan",
                "org": ""
            },
            {
                "name": "Yu Liu",
                "org": ""
            },
            {
                "name": "Adham Sameer A. Bardeesi",
                "org": ""
            },
            {
                "name": "Jingfeng Wang",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Hui Huang",
                "org": ""
            }
        ],
        "venue": "Medicine",
        "year": 2016
    },
    "MCl9M2LE": {
        "id": "MCl9M2LE",
        "title": "Malnutrition, a new inducer for arterial calcification in hemodialysis patients?",
        "abstract": "Arterial calcification is a significant cardiovascular risk factor in hemodialysis patients. A series of factors are involved in the process of arterial calcification; however, the relationship between malnutrition and arterial calcification is still unclear.68 hemodialysis patients were enrolled in this study. Nutrition status was evaluated using modified quantitative subjective global assessment (MQSGA). Related serum biochemical parameters were measured. And the radial artery samples were collected during the arteriovenous fistula surgeries. Hematoxylin/eosin stain was used to observe the arterial structures while Alizarin red stain to observe calcified depositions and classify calcified degree. The expressions of bone morphogenetic protein 2 (BMP2) and matrix Gla protein (MGP) were detected by immunohistochemistry and western blot methods.66.18% hemodialysis patients were malnutrition. In hemodialysis patients, the calcified depositions were mainly located in the medial layer of the radial arteries and the expressions of BMP2 and MGP were both increased in the calcified areas. The levels of serum albumin were negatively associated with calcification score and the expressions of BMP2 and MGP. While MQSGA score, serum phosphorus and calcium\u2009\u00d7\u2009phosphorus product showed positive relationships with calcification score and the expressions of BMP2 and MGP.Malnutrition is prevalent in hemodialysis patients and is associated with arterial calcification and the expressions of BMP2 and MGP in calcified radial arteries. Malnutrition may be a new inducer candidate for arterial calcification in hemodialysis patients.",
        "keywords": [
            "immunohistochemistry",
            "phosphorus",
            "extracellular matrix proteins",
            "calcium binding proteins",
            "bone morphogenetic protein 2",
            "calcium",
            "serum albumin",
            "malnutrition"
        ],
        "authors": [
            {
                "name": "Kun Zhang",
                "org": "Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 107 West Yanjiang Road, Guangzhou 510120, China."
            },
            {
                "name": "Gang Cheng",
                "org": ""
            },
            {
                "name": "Xue Cai",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Ying Jiang",
                "org": ""
            },
            {
                "name": "Tong Wang",
                "org": ""
            },
            {
                "name": "Jingfeng Wang",
                "org": ""
            },
            {
                "name": "Hui Huang",
                "org": ""
            }
        ],
        "venue": "Journal of translational medicine",
        "year": 2013
    },
    "HBoi2VUg": {
        "id": "HBoi2VUg",
        "title": "A1564 Abnormal Mineral Metabolism but not Traditional Cardiovascular Risk Factors was associated with High ABI in Patients with Peritoneal Dialysis: a Mediation Analysis",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Hui Huang",
                "org": ""
            },
            {
                "name": "Wanbing He",
                "org": ""
            },
            {
                "name": "Xiaoyan Su",
                "org": ""
            },
            {
                "name": "Yinyin Zhang",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Hongquan Peng",
                "org": ""
            },
            {
                "name": "Weidong Wang",
                "org": ""
            },
            {
                "name": "Jingfeng Wang",
                "org": ""
            }
        ],
        "venue": "Journal of Hypertension",
        "year": 2018
    },
    "bbkIQCd4": {
        "id": "bbkIQCd4",
        "title": "Apocynin attenuates angiotensin II-induced vascular smooth muscle cells osteogenic switching via suppressing extracellular signal-regulated kinase 1/2.",
        "abstract": "Vascular calcification (VC) is a significant risk factor for cardiovascular morbidity and mortality. We recently reported that apocynin had benefits for preventing cardiovascular diseases. However, whether apocynin could attenuate VC is unknown. Here, we investigated the role of apocynin in VC and its underlying mechanisms. 163 participants with high or normal ankle-brachial index (ABI) were enrolled in this study for analyzing the demographic and biochemical data. In vitro, vascular smooth muscle cells (VSMCs) were exposed to calcification medium containing b-glycerophosphate and angiotensin II (Ang II) for 24 hours. The results showed that serum level of Ang II was significantly increased in patients with high ABI (P<0.05). In cultured VSMCs, Ang II significantly exacerbated osteogenic switching. The expression of osteogenic phenotype markers, including bone morphogenetic protein 2 (BMP2), runt-related transcription factor 2 (Runx2) and osteopontin (OPN), were significantly upregulated, whereas contractile markers expression, including alpha smooth muscle actin (a-SMA) and smooth muscle 22 alpha (SM22a) were simultaneously downregulated. However, these effects were greatly attenuated by apocynin. Apocynin enhanced expression of a-SMA by 5.3%, and reduced expression of BMP2, Runx2, OPN by 3.37%, 0.61% and 3.07%, respectively. Furthermore, extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation was upregulated by Ang II, and this effect was also reversed by apocynin. Intriguingly, pretreatment with U0126, an inhibitor of ERK1/2, had similar effects with apocynin. Apocynin may act as a novel molecular candidate to protect against VSMCs osteogenic switching through suppressing ERK1/2 pathway.",
        "keywords": [
            "angiotensin II",
            "apocynin",
            "osteogenic switching",
            "vascular calcification",
            "vascular smooth muscle cells"
        ],
        "authors": [
            {
                "name": "Weijing Feng",
                "org": "Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Kun Zhang",
                "org": "Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Yu Liu",
                "org": "Department of Cardiology, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Radiation Oncology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China."
            },
            {
                "name": "Qingqing Cai",
                "org": "Department of Medical Oncology, Sun Yat-sen University Cancer Center, Sun Yat-sen University, Guangzhou, China."
            },
            {
                "name": "Yinyin Zhang",
                "org": "Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Mongheng Wang",
                "org": "Department of Physiology, Georgia Regents University, Augusta, GA, USA."
            },
            {
                "name": "Jingfeng Wang",
                "org": "Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Hui Huang",
                "org": "Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China."
            }
        ],
        "venue": "Oncotarget",
        "year": 2016
    },
    "mKZULzmo": {
        "id": "mKZULzmo",
        "title": "Serum apolipoprotein A-I is a novel prognostic indicator for non-metastatic nasopharyngeal carcinoma.",
        "abstract": "We investigated the value of pretreatment serum apolipoprotein A-I (ApoA-I) in complementing TNM staging in the prognosis of non-metastatic nasopharyngeal carcinoma (NPC).We retrospectively reviewed 1196 newly diagnosed patients with non-metastatic NPC. Disease-specific survival (DSS), distant metastasis-free survival (DMFS), and locoregional recurrence-free survival (LRFS) rates were compared according to serum ApoA-I level. Multivariate analysis was performed to assess the prognostic value of serum ApoA-I.The 5-year DSS, DMFS, and LRFS rates for patients with elevated or decreased serum ApoA-I were 81.3% versus 69.3% (P < 0.001), 83.4% versus 67.4% (P < 0.001), and 80.9% versus 67.3% (P < 0.001), respectively. ApoA-I \u2265 1.025 g/L was an independent prognostic factor for superior DSS, DMFS, and LRFS in multivariate analysis. After stratification by clinical stage, serum ApoA-I remained a clinically and statistically significant predictor of prognosis.Our data suggest that the level of ApoA-I at diagnosis is a novel independent prognostic marker that could complement clinical staging for risk definition in non-metastatic NPC.",
        "keywords": [
            "apolipoprotein A-I (ApoA-I)",
            "non-metastatic nasopharyngeal carcinoma (NPC)",
            "prognosis"
        ],
        "authors": [
            {
                "name": "Xiao-Lin Luo",
                "org": "Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China."
            },
            {
                "name": "Guang-Zheng Zhong",
                "org": "Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China."
            },
            {
                "name": "Li-Yang Hu",
                "org": "Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China."
            },
            {
                "name": "Jie Chen",
                "org": "Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology, Radiotherapy Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China."
            },
            {
                "name": "Ying Liang",
                "org": "Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China."
            },
            {
                "name": "Qiu-Yan Chen",
                "org": "Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China."
            },
            {
                "name": "Qing Liu",
                "org": "Department of Cancer Prevention Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China."
            },
            {
                "name": "Hui-Lan Rao",
                "org": "Department of Pathology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China."
            },
            {
                "name": "Kai-Lin Chen",
                "org": "Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China."
            },
            {
                "name": "Qing-Qing Cai",
                "org": "Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China."
            }
        ],
        "venue": "Oncotarget",
        "year": 2015
    },
    "hTbdOarY": {
        "id": "hTbdOarY",
        "title": "Combined blockade of renin-angiotensin-aldosterone system reduced all-cause but not cardiovascular mortality in dialysis patients: A mediation analysis and systematic review.",
        "abstract": "Full blockade of renin-angiotensin-aldosterone system (RAAS) is believed to decrease morbidity and mortality of patients with chronic kidney disease. In non-dialysis patients, combined RAAS blockade with two different RAAS blockers causes more adverse events without improving survival, but its role in maintenance dialysis patients is still unclear. We conducted a systematic review and mediation analysis to investigate the efficacy and safety of combined RAAS blockade in dialysis patients.Comprehensive search was conducted in PubMed, EMBASE, Web of Science and Cochrane Library database to June 2017 to identify relevant studies. Studies comparing combined with single RAAS blockade and reporting all-cause death, cardiovascular death, hypotension or hyperkalemia in dialysis patients were included. Effect sizes were calculated with randomized effects model and summarized as odd ratios (OR).A total of 9 studies with 13,050 dialysis patients were included. Compared with single blockade, combined blockade significantly reduced all-cause mortality (OR 0.71, 95% confidence interval 0.54-0.93, p = 0.01), while cardiovascular mortality remained unchanged (0.85, 0.45-1.59, p = 0.61). Combined blockade tended to increase odd of hypotension but not odd of hyperkalemia (1.54, 1.00-2.38, p = 0.05; 0.89, 0.76-1.05, p = 0.17). Further mediation analysis indicated that hypotension might exert a suppression effect on the survival benefit of angiotensin-converting enzyme inhibitor plus angiotensin receptor blocker treatment on cardiovascular mortality.Combined RAAS blockade might be a promising treatment in dialysis patients to further reduce mortality if blood pressure was well controlled.",
        "keywords": [
            "Combined blockade",
            "Dialysis",
            "Efficacy",
            "Mortality",
            "Renin-angiotensin-aldosterone system",
            "Safety"
        ],
        "authors": [
            {
                "name": "Shao-Min Li",
                "org": "Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120 China; Division of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630 China; Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120 China."
            },
            {
                "name": "Wan-Bing He",
                "org": "Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120 China; Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120 China."
            },
            {
                "name": "Jie Chen",
                "org": "Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120 China; Radiotherapy Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120 China."
            },
            {
                "name": "Qing-Qing Cai",
                "org": "Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, 510060 China."
            },
            {
                "name": "Fei-Fei Huang",
                "org": "Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120 China; Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120 China."
            },
            {
                "name": "Kun Zhang",
                "org": "Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120 China; Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120 China."
            },
            {
                "name": "Jing-Feng Wang",
                "org": "Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120 China; Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120 China."
            },
            {
                "name": "Xun Liu",
                "org": "Division of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630 China."
            },
            {
                "name": "Hui Huang",
                "org": "Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120 China; Laboratory of RNA and Major Diseases of Brain and Heart, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120 China."
            }
        ],
        "venue": "Atherosclerosis",
        "year": 2017
    },
    "0Tf4O4H8": {
        "id": "0Tf4O4H8",
        "title": "Apocynin Attenuates Cardiac Injury in Type 4 Cardiorenal Syndrome via Suppressing Cardiac Fibroblast Growth Factor-2 With Oxidative Stress Inhibition",
        "abstract": "",
        "keywords": [
            "cerebrovascular disease"
        ],
        "authors": [
            {
                "name": "yang liu",
                "org": ""
            },
            {
                "name": "xun liu",
                "org": "sun yat sen university"
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "kun zhang",
                "org": ""
            },
            {
                "name": "feifei huang",
                "org": ""
            },
            {
                "name": "jingfeng wang",
                "org": ""
            },
            {
                "name": "wanchun tang",
                "org": ""
            },
            {
                "name": "hui huang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2015
    },
    "oYCQJKBH": {
        "id": "oYCQJKBH",
        "title": "Type D personality parents of children with leukemia tend to experience anxiety: the mediating effects of social support and coping style.",
        "abstract": "The aims were to access anxiety and type D personality (TDP) in parents of children with leukemia, and to determine the mediating effect of social support and coping style on the relationship between TDP and anxiety. A cross-sectional study was conducted among 231 parents of children with leukemia and 261 parents of children with acute diseases in hospitals. Parents completed questionnaires on anxiety, TDP, social support, coping styles, children's clinical characteristics, and demographic characteristics. Parents of children with leukemia showed higher prevalence of anxiety (64.5% vs 40.2%, P\u200a<\u200a0.01) and TDP (44.2% vs 24.1%, P\u200a<\u200a0.01) compared with controls. TDP (odds ratio [OR]\u200a=\u200a4.34, P\u200a<\u200a0.01), lower social support (OR\u200a=\u200a1.92, P\u200a=\u200a0.02), and less positive coping (OR\u200a=\u200a1.87, P\u200a=\u200a0.02) were independently associated with anxiety. Parents with TDP showed lower social support and less positive coping, but more negative coping compared with those without. Moreover, multiple mediation analyses revealed that the significant effect of TDP on anxiety was partially mediated by social support and positive coping. In conclusion, anxiety and TDP were highly prevalent in parents of children with leukemia. The predictive factors could be used to identify those parents who are at high risk of anxiety and may also be targets for prevention and intervention.",
        "keywords": [],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "From the Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology (JC, YL, TW, KZ, JFW, HH); Sun Yat-sen Memorial Hospital of Sun Yat-sen University (JC, YL, YML, TW, KZ, JFW, HH); Department of Internal Medicine (QQC), Cancer Center; and Department of Biostatistics and Epidemiology (WQC), School of Public Health, Sun Yat-sen University, Guangzhou, China."
            },
            {
                "name": "Yang Liu",
                "org": ""
            },
            {
                "name": "Qing-Qing Cai",
                "org": ""
            },
            {
                "name": "Yi-Min Liu",
                "org": ""
            },
            {
                "name": "Tong Wang",
                "org": ""
            },
            {
                "name": "Kun Zhang",
                "org": ""
            },
            {
                "name": "Jing-Feng Wang",
                "org": ""
            },
            {
                "name": "Wei-qing Chen",
                "org": ""
            },
            {
                "name": "Hui Huang",
                "org": ""
            }
        ],
        "venue": "Medicine",
        "year": 2015
    },
    "scYks3zF": {
        "id": "scYks3zF",
        "title": "Apocynin improving cardiac remodeling in chronic renal failure disease is associated with up-regulation of epoxyeicosatrienoic acids",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "kun zhang",
                "org": ""
            },
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "xiaoqiang liu",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "qingqing cai",
                "org": ""
            },
            {
                "name": "jingfeng wang",
                "org": ""
            },
            {
                "name": "hui huang",
                "org": ""
            }
        ],
        "venue": "Oncotarget",
        "year": 2015
    },
    "qow3NutD": {
        "id": "qow3NutD",
        "title": "ASSA14-03-02 Protective Effects of Paeoniflorin against Myocardial Fibrosis in Isoprenaline-induced Chronic Heart Failure Rats",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jenyang chen",
                "org": "sun yat sen university"
            },
            {
                "name": "meng liu",
                "org": "sun yat sen university"
            },
            {
                "name": "ling ling li",
                "org": "institute of medical science"
            },
            {
                "name": "j t ke",
                "org": "sun yat sen university"
            },
            {
                "name": "w y zhou",
                "org": "institute of medical science"
            },
            {
                "name": "derray huang",
                "org": "sun yat sen university"
            },
            {
                "name": "weigang wu",
                "org": "sun yat sen university"
            }
        ],
        "venue": "Heart",
        "year": 2015
    },
    "kOcG7C5z": {
        "id": "kOcG7C5z",
        "title": "Independent influence of overweight and obesity on the regression of left ventricular hypertrophy in hypertensive patients: a meta-analysis.",
        "abstract": "Overweight and obesity are associated with adverse cardiovascular outcomes. However, the role of overweight and obesity in left ventricular hypertrophy (LVH) of hypertensive patients is controversial. The aim of the current meta-analysis was to evaluate the influence of overweight and obesity on LVH regression in the hypertensive population.Twenty-eight randomized controlled trials comprising 2403 hypertensive patients (mean age range: 43.8-66.7 years) were identified. Three groups were divided according to body mass index: normal weight, overweight, and obesity groups.Compared with the normal-weight group, LVH regression in the overweight and obesity groups was more obvious with less reduction of systolic blood pressure after antihypertensive therapies (P\u200a<\u200a0.001). The renin-angiotensin system inhibitor was the most effective in regressing LVH in overweight and obese hypertensive patients (19.27\u200ag/m, 95% confidence interval [15.25, 23.29], P\u200a<\u200a0.001), followed by \u03b2-blockers, calcium channel blockers, and diuretics. In the stratified analysis based on blood pressure measurement methods and age, more significant LVH regression was found in 24-h ambulatory blood pressure monitoring (ABPM) group and in relatively young patients (40-60 years' old) group (P\u200a<\u200a0.01).Overweight and obesity are independent risk factors for LVH in hypertensive patients. Intervention at an early age and monitoring by ABPM may facilitate therapy-induced LVH regression in overweight and obese hypertensive patients.",
        "keywords": [],
        "authors": [
            {
                "name": "Kun Zhang",
                "org": "From the Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University (KZ, FH, JW, HH); Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology (KZ, FH, JC, TW, RZ, JW, HH); Department of Radiation Oncology, Sun Yat-sen Memorial Hospital (JC); Department of Internal Medicine, Cancer Center, Sun Yat-sen University, Guangzhou, China (QC); and Department of Anesthesiology, University of Virginia Health System, Charlottesville, VA, USA (ZZ)."
            },
            {
                "name": "Feifei Huang",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Qingqing Cai",
                "org": ""
            },
            {
                "name": "Tong Wang",
                "org": ""
            },
            {
                "name": "Rong Zou",
                "org": ""
            },
            {
                "name": "Zhiyi Zuo",
                "org": ""
            },
            {
                "name": "Jingfeng Wang",
                "org": ""
            },
            {
                "name": "Hui Huang",
                "org": ""
            }
        ],
        "venue": "Medicine",
        "year": 2014
    },
    "fnxa1deQ": {
        "id": "fnxa1deQ",
        "title": "Inflammation and oxidative stress are associated with the prevalence of high aankle-brachial index in metabolic syndrome patients without chronic renal failure.",
        "abstract": "High ankle-brachial index (ABI) is marker of increased cardiovascular morbidity and mortality, while the relationship and mechanism between high ABI and metabolic syndrome (MetS) are unclear. The objectives of this study were to determine the relationship and possible mechanism of MetS with high ABI.341 participants without CRF were recruited. Among these participants, 58 participants (ABI \u2265 1.3) were include in high ABI group and the other 283 participants (0.9 < ABI < 1.3) were include in normal ABI group. Furthermore, these 341 participants were also divided into MetS group (n = 54) and non-MetS group (n = 287). All participants received examinations including body mass index (BMI), ABI and related biochemical parameters.Compared with non-MetS group, the prevalence of high ABI was higher in MetS group (27.8% vs. 15%, p < 0.05). Participants with 3-4 metabolic risk factors had higher prevalence of high ABI than those with 0-1 metabolic risk factors (27.8% vs. 12.7%, p < 0.05). The prevalence of high ABI in overweight participants was higher than those with normal body weight. And the participants with hypertension also had higher prevalence of high ABI than normotensive participants. BMI, high-sensitivity C-reactive protein (hsCRP) and superoxide dismutase (SOD) were all higher in high ABI group than normal ABI group (p < 0.05).More metabolic risk factors have increased the risk of high ABI. Inflammation and oxidative stress are associated with prevalence of high ABI in metabolic syndrome patients without chronic renal failure.",
        "keywords": [
            "high ankle-brachial index",
            "inflammation",
            "metabolic risk factors",
            "metabolic syndrome",
            "oxidative stress",
            "risk factors"
        ],
        "authors": [
            {
                "name": "Yinyin Zhang",
                "org": "Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 510120 China."
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Kun Zhang",
                "org": ""
            },
            {
                "name": "Minyi Kong",
                "org": ""
            },
            {
                "name": "Tao Wang",
                "org": ""
            },
            {
                "name": "Renhua Chen",
                "org": ""
            },
            {
                "name": "Lily Wang",
                "org": ""
            },
            {
                "name": "Jingfeng Wang",
                "org": ""
            },
            {
                "name": "Hui Huang",
                "org": ""
            }
        ],
        "venue": "International journal of medical sciences",
        "year": 2013
    },
    "kjd1Wc79": {
        "id": "kjd1Wc79",
        "title": "Expression and clinical value of programmed cell death-ligand 1 (PD-L1) in diffuse large B cell lymphoma: a retrospective study.",
        "abstract": "PD-L1 expression is more common in the non-GCB subtype than in the GCB subtype. PD-L1 expression in tumor microenvironment has a negative correlation with C-Myc. PD-L1 positivity predicts short survival in DLBCL patients. For patients with PD-L1 expression, more strategy such as anti-PD-L1 antibody treatment should be recommended.",
        "keywords": [
            "C-Myc",
            "Diffuse large B-cell lymphoma",
            "Prognosis",
            "Programmed cell death-ligand 1 (PD-L1)"
        ],
        "authors": [
            {
                "name": "Li-Yang Hu",
                "org": "Department of Medical Oncology, The Fifth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 519000, Guangdong, P. R. China."
            },
            {
                "name": "Xiao-Lu Xu",
                "org": "Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, P. R. China."
            },
            {
                "name": "Hui-Lan Rao",
                "org": "Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, P. R. China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Radiotherapy, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, 510120, Guangdong, P. R. China."
            },
            {
                "name": "Ren-Chun Lai",
                "org": "Department of Anesthesiology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, P. R. China."
            },
            {
                "name": "Hui-Qiang Huang",
                "org": "Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, P. R. China."
            },
            {
                "name": "Wen-Qi Jiang",
                "org": "Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, P. R. China."
            },
            {
                "name": "Tong-Yu Lin",
                "org": "Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, P. R. China."
            },
            {
                "name": "Zhong-Jun Xia",
                "org": "Department of Hematology Oncology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, P. R. China."
            },
            {
                "name": "Qing-Qing Cai",
                "org": "Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, P. R. China. caiqq@sysucc.org.cn."
            }
        ],
        "venue": "Chinese journal of cancer",
        "year": 2017
    },
    "PYuOxanU": {
        "id": "PYuOxanU",
        "title": "Bioequivalence of Oral Formulations of Anastrozole in Healthy Chinese Male Volunteers: A Randomized, Single-Dose, Two-Period, Two-Sequence Crossover Study.",
        "abstract": "Anastrozole is currently used as first-line treatment in locally advanced or metastatic breast cancer. A generic anastrozole tablet was developed to offer an alternative to the marketed tablet formulation. The aim of the current study was to evaluate the bioequivalence between the test and reference formulations of anastrozole in a single-dose, 2-period, 2-sequence crossover study with a 14-day washout interval. A total of 20 healthy male Chinese volunteers were enrolled and completed the study, after oral administration of a single dose of 1.0-mg test and reference formulations of anastrozole. The blood samples were collected at different times and were determined by a fully validated high-pressure liquid chromatography-tandem mass spectrometry method. The evaluated pharmacokinetic parameters, including C , AUC , and AUC , were assessed for bioequivalence based on current guidelines. The observed pharmacokinetic parameters of anastrozole of the test drug were similar to those of the reference formulation. The 90% confidence intervals of test/reference ratios for C , AUC , and AUC were within the bioequivalence acceptance range of 80%-125%. The results obtained from these healthy Chinese subjects in this study suggest that the test formulation of anastrozole 1.0-mg tablet is bioequivalent to the reference formulation (Arimidex 1.0-mg tablet).",
        "keywords": [
            "LC-MS/MS",
            "anastrozole",
            "bioequivalence",
            "pharmacokinetics"
        ],
        "authors": [
            {
                "name": "Jiangying Chen",
                "org": "Laboratory of Drug Metabolism and Pharmacokinetics, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Jialang Zhuang",
                "org": "Laboratory of Drug Metabolism and Pharmacokinetics, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Jingguo Wu",
                "org": "The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Xiaoyan Chen",
                "org": "Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China."
            },
            {
                "name": "Xueding Wang",
                "org": "Laboratory of Drug Metabolism and Pharmacokinetics, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Lihui Huang",
                "org": "Laboratory of Drug Metabolism and Pharmacokinetics, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Guixiong Zeng",
                "org": "Laboratory of Drug Metabolism and Pharmacokinetics, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Jie Chen",
                "org": "The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Xiaoxing Liao",
                "org": "The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Xiao Chen",
                "org": "The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Zhongfu Ma",
                "org": "The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Guoping Zhong",
                "org": "Laboratory of Drug Metabolism and Pharmacokinetics, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Min Huang",
                "org": "Laboratory of Drug Metabolism and Pharmacokinetics, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China."
            },
            {
                "name": "Dafang Zhong",
                "org": "Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China."
            },
            {
                "name": "Xianglan Zhao",
                "org": "Laboratory of Drug Metabolism and Pharmacokinetics, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China."
            }
        ],
        "venue": "Clinical pharmacology in drug development",
        "year": 2018
    },
    "zjiUdcIx": {
        "id": "zjiUdcIx",
        "title": "Exosomes, the message transporters in vascular calcification",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Chao Zhang",
                "org": "Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Department of Cardiology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou China"
            },
            {
                "name": "Kun Zhang",
                "org": "Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Department of Cardiology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou China"
            },
            {
                "name": "Feifei Huang",
                "org": "Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Department of Cardiology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou China"
            },
            {
                "name": "Weijing Feng",
                "org": "Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Department of Cardiology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou China"
            },
            {
                "name": "Jie Chen",
                "org": "RNA Biomedical Institute Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University GuangZhou China"
            },
            {
                "name": "Huanji Zhang",
                "org": "Cardiovascular Department The Eighth Affiliated Hospital Sun Yat\u2010sen University Shenzhen China"
            },
            {
                "name": "Jingfeng Wang",
                "org": ""
            },
            {
                "name": "Pei Luo",
                "org": "State Key Laboratories for Quality Research in Chinese Medicines Macau University of Science and Technology Macau China"
            },
            {
                "name": "Hui Huang",
                "org": "Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Department of Cardiology Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou China"
            }
        ],
        "venue": "Journal of Cellular and Molecular Medicine",
        "year": 2018
    },
    "Ocvtvah7": {
        "id": "Ocvtvah7",
        "title": "GW29-e1852 Coronary Artery Calcification Mediates the Association between 24-Hour Systolic Blood Pressure Variability and Major Adverse Cardiac Events",
        "abstract": "Blood pressure variability (BPV), have been recently identified as an important risk factor for the development of cardiovascular diseases (CVD) independent of mean blood pressure. Coronary artery calcification (CAC) has demonstrated to be an independent predictor of major adverse cardiac events (",
        "keywords": "",
        "authors": [
            {
                "name": "Weijing Feng",
                "org": "Department of Cardiology"
            },
            {
                "name": "Weijing Feng",
                "org": "Department of Cardiology"
            },
            {
                "name": "Kun Zhang",
                "org": "Department of Cardiology"
            },
            {
                "name": "Kun Zhang",
                "org": "Department of Cardiology"
            },
            {
                "name": "Suihua Huang",
                "org": "Department of Cardiology"
            },
            {
                "name": "Suihua Huang",
                "org": "Department of Cardiology"
            },
            {
                "name": "Feifei Huang",
                "org": "Department of Cardiology"
            },
            {
                "name": "Feifei Huang",
                "org": "Department of Cardiology"
            },
            {
                "name": "Zhibin Li",
                "org": "Department of Cardiology"
            },
            {
                "name": "Zhibin Li",
                "org": "Department of Cardiology"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Radiation Oncology"
            },
            {
                "name": "Jingfeng Wang",
                "org": ""
            },
            {
                "name": "Jingfeng Wang",
                "org": ""
            },
            {
                "name": "Hui Huang",
                "org": "Department of Cardiology"
            },
            {
                "name": "Hui Huang",
                "org": "Department of Cardiology"
            }
        ],
        "venue": "Journal of the American College of Cardiology",
        "year": 2018
    },
    "5EW3y6xT": {
        "id": "5EW3y6xT",
        "title": "Expression of Fas/FasL on peripheral Blood T Lymphocytes in Asthmatic Children and its Significance",
        "abstract": "Objective To investigated the expression of Fas/FasL on peripheral blood T cells in asthmatic children and to explore the relationship between its clinical significance.Methods Lymphocytes were isolated with ficoll-hypaque gradient method and T lymphocytes were further purified with nylon pili.Expression of Fas/FasL was detected by immunofluoresence technology.Results Expression of Fas on T cells in 21 cases of the stage of attack(5.81\u00b13.29) and in 15 cases of remission stage(9.86\u00b14.54) were remarkably lower than those in 25 healthy children(13.72\u00b15.33)(P<0.01).Expression of FasL on T cells in the stage of attack(3.22\u00b11.74) was significantly increased compared with normal control group(2.31\u00b11.05)(P<0.05) but those in remission patients(2.97\u00b11.28) was not significantly changed.There was a remarkable negative relationship between expression of Fas and percentages of peripheral blood lymphocyte(r=-0.632,P<0.01).Conclusion The apoptosis of peripheral blood T lymphocytes from the children with asthma both in stage of attack and remission are decreased.The inhibited apoptosis might be one of reasons for the chronic persistent inflammation in the airways in asthmatic children and suggests that it is necessary to continue therapy in remission stage.",
        "keywords": [
            "Fas",
            "Lymphocyte",
            "Asthma",
            "FasL",
            "Child"
        ],
        "authors": [
            {
                "name": "YUAN Yue-sha",
                "org": "Department of Pediatrics,Clinical Medical Sclool of Yangtze University,Jingzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Laboratory of Clinical Molecular Medicine,Medical School of Yangtze University,Jingzhou ,China"
            },
            {
                "name": "WANG Lin",
                "org": ""
            },
            {
                "name": "ZHOU Shao-hua",
                "org": "Department of Pediatrics,The Affiliated Hospital of Yangtze University,,China"
            }
        ],
        "venue": "Lishizhen Medicine and Materia Medica Research",
        "year": 2008
    },
    "KLuwcETB": {
        "id": "KLuwcETB",
        "title": "Interleukin-27 affects IFN-\u03b3 and IL-4 activities in children with asthma",
        "abstract": "Objective To study the effect of interleukin(IL)-27 on INF and IL-4 activities in children with asthma.Methods The levels of IFN-\u03b3 and IL-4 in culture supernatants of peripheral blood mononuclear cells(PBMCs) from 23 asthmatic children were measured using ELISA.PBMCs were cultured with recombinant IL-27(5 ng /mL or 0.5 ng /mL)for 12 hrs in vitro.Results IFN-\u03b3 levels in both 5 ng /mL and 0.5 ng /mL IL-27 treatment groups(85.9 \u00b1 12.2 and 8.9 \u00b1 2.3 \u03bcg /L,respectively) increased compared with those in the cytokine stimulated control group(P < 0.01,P < 0.05 respectively).The group treated with 5 ng /mL IL-27 had decreased significantly IL-4 levels compared with the cytokine stimulated control group(15.0 \u00b1 1.9 \u03bcg /L vs 77.0 \u00b1 15.6 \u03bcg /L;P < 0.01).Conclusions IL-27 may be involved in the pathogenesis of asthma.It may affect Th1 /Th2 cell activities and might be a new option for the treatment of asthma.",
        "keywords": [
            "Asthma",
            "Child",
            "Interleukin-27",
            "T lymphocyte"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Yangtze University(Yangtze University ^),Jingzhou,China"
            },
            {
                "name": "YUAN Yue-Sha",
                "org": "Yangtze University(Yangtze University ^),Jingzhou,China"
            },
            {
                "name": "Qi Li",
                "org": "Yangtze University(Yangtze University ^),Jingzhou,China"
            },
            {
                "name": "Mei Liu",
                "org": "Yangtze University(Yangtze University ^),Jingzhou,China"
            },
            {
                "name": "ZHOU Shao-Hua",
                "org": "Yangtze University(Yangtze University ^),Jingzhou,China"
            },
            {
                "name": "Wei Jin",
                "org": "Yangtze University(Yangtze University ^),Jingzhou,China"
            }
        ],
        "venue": "Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics",
        "year": 2010
    },
    "PYSLeqFp": {
        "id": "PYSLeqFp",
        "title": "Changes of T Cell Subsets and Regulation of Cytokine on Helper T Cell in Asthmatic Children",
        "abstract": "Objective To investigate the changes of T lymphocyte subsets in asthmatic children and effect of IL-27 on cytokine production of helper T lymphocyte subsets(Th1/Th2).Methods The subsets of T lymphocyte in 10 cases of asthmatic children(asthmatic group)in attacking stage and 5 healthy children(healthy control group)were measured by flow cytometry.PBMCs from 10 asthmatic children were cultured with recombinant human IL-27(5 \u03bcg\u00b7L-1 or 0.5 \u03bcg\u00b7L-1)for 12 h in vitro,and then the levels of IFN and IL-4 in their supernatant were measured by ELISA.Results The levels of CD4+ T cell [(38.408\u00b13.808)%] and ratio of CD4+/CD8+ T cell(1.480\u00b10.155)in asthmatic children were significantly increased than those in healthy control group [(28.240\u00b11.936)%,1.151\u00b10.092](Pa<0.05),but the levels of CD3+ T cell[(60.354\u00b14.770)%] and CD8+ T cell[(26.080\u00b12.592)%] in asthmatic group had no remarkable difference compared with healthy control group[(61.978\u00b14.020)%,(24.706\u00b12.753)%](Pa>0.05).PBMCs from children were divi-ded into 3 groups,5.0 \u03bcg\u00b7L-1 IL-27 group,0.5 \u03bcg\u00b7L-1 IL-27 group and the healthy control group.The values of IFN-\u03b3 in supernatant were(116.160\u00b154.89)\u03bcg\u00b7L-1,(9.369\u00b16.910)\u03bcg\u00b7L-1 and(7.844\u00b18.380)\u03bcg\u00b7L-1,respectively.The levels of IFN-\u03b3 after stimulation with IL-27 were remarkably higher than those in healthy control group(Pa<0.005).The levels of IL-4 in 5.0 \u03bcg\u00b7L-1 IL-27 group,0.5 \u03bcg\u00b7L-1 IL-27 group and healthy control group were(12.600\u00b12.433)\u03bcg\u00b7L-1,(81.480\u00b16.396)\u03bcg\u00b7L-1 and(70.820\u00b122.912)\u03bcg\u00b7L-1,respectively.The levels of IL-4 in 5 \u03bcg\u00b7L-1 IL-27 group had a significant decrease compared with that in healthy control group(P<0.01),but the value of IL-4 in 0.5 \u03bcg\u00b7L-1 IL-27 group had no significant difference compared with that in healthy control group(P>0.05).Conclusions CD4+ T cell plays an important role in the pathogenesis in asthmatic children.IL-27 is involved in affecting Th1/Th2 cells activity;so IL-27 may be a beneficial agent for asthma.",
        "keywords": [
            "child",
            "interleukin-27",
            "asthma",
            "T lymphocyte"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Department of Pediatrics,Clinical Medical School of Yangtze University,Jingzhou ,Hubei Province,China;Department of Respiration,the Second People's Hospital of Huangshi,Huangshi ,Hubei Province,China"
            },
            {
                "name": "YUAN Yue-sha",
                "org": "Department of Pediatrics,Clinical Medical School of Yangtze University,Jingzhou ,Hubei Province,China;Department of Pediatrics,the First Affiliated Hospital of Yangtze University,Jingzhou ,Hubei Province,China"
            },
            {
                "name": "LI Qi",
                "org": "Department of Clinical Immunology Laboratory,the First Affiliated Hospital of Yangtze University,Jingzhou ,Hubei Province,China"
            },
            {
                "name": "LIU Mei",
                "org": "Department of Pediatrics,the First Affiliated Hospital of Yangtze University,Jingzhou ,Hubei Province,China"
            },
            {
                "name": "JIN Wei",
                "org": "Department of Respiration,the Second People's Hospital of Huangshi,Huangshi ,Hubei Province,China"
            },
            {
                "name": "ZHOU Shao-hua",
                "org": "Department of Pediatrics,the First Affiliated Hospital of Yangtze University,Jingzhou ,Hubei Province,China"
            }
        ],
        "venue": "Journal of Applied Clinical Pediatrics",
        "year": 2010
    },
    "BsU2w0S3": {
        "id": "BsU2w0S3",
        "title": "Effect of Chinese Herbs on Inflammatory Cytokines in Children with Asthma",
        "abstract": "Objective To explore the effect of Lishi Xiaochuan on inflammatory cytokines in asthmatic children.Methods Serum IL-18,IgE and TNF-\u03b1 were detected by enzyme linked immunosorbent assay(ELISA) in 17 children with asthma and 20 health children.Results Serum IL-18,IgE and TNF-\u03b1 level in 17 cases of the stage of attack(212.79\u00b114.77;235.71\u00b123.73;99.12\u00b19.06)(P<0.01)were remarkably higher than those in 20 healthy children(64.30\u00b18.13,60.85\u00b17.94,38.40\u00b14.96)(P<0.01).There was a remarkably positive relationship between serum IL-18,IgE and TNF-\u03b1 level.(r=0.696;r=0.653).Conclusion Lishi Xiaochuan has a decreasing effect on seram levels of IL-18,IgE and INF-a in asthmatic children.",
        "keywords": [
            "IL-18",
            "Inflammtory factors",
            "Asthma",
            "Child"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Medical School of Yangtze University,Jingzhou,,China"
            },
            {
                "name": "YUAN Yue-sha",
                "org": "Clinical Medical School of Yangtze University,Jingzhou,,China"
            },
            {
                "name": "HUANG Hu-xiang",
                "org": "Medical School of Yangtze University,Jingzhou,,China"
            },
            {
                "name": "LIU Dan",
                "org": "Medical School of Yangtze University,Jingzhou,,China"
            },
            {
                "name": "WANG Lin",
                "org": "Affiliated Hospital of Yangtze University,Jingzhou,,China"
            },
            {
                "name": "ZHOU Shao-hua",
                "org": "Affiliated Hospital of Yangtze University,Jingzhou,,China"
            }
        ],
        "venue": "Lishizhen Medicine and Materia Medica Research",
        "year": 2009
    },
    "HvSAYtQt": {
        "id": "HvSAYtQt",
        "title": "Study on the level of Th1 and Th2 in the sera of patients with allergic rhinitis",
        "abstract": "Objective Study on the level of T helper cell (Th1 and Th2)in patients with allergic rhinitis.Methods Serum IFN-\u03b3,IL-27 and IL-4 were detected by enzyme linked immunosorbent assay (ELISA) in 20 patients with asthma and 18 health persons.Results Serum IFN-\u03b3 and IL-27 level in 20 cases of the stage of attack were remarkably lower than those in 18 health persons (P<0.01).Serum IL-4 level were remarkably higher than those in 18 health persons(P<0.01).Conclusion The outbreak of allergic rhinitis by Th1 and Th2 cytokines,and Th1 / Th2 ratio imbalance may cause the disease of allergic rhinitis.",
        "keywords": [
            "interleupin 27",
            "interferon gama",
            "allergic rhinitis",
            "interleupin 4",
            "T helper cell"
        ],
        "authors": [
            {
                "name": "YUAN Yue-sha",
                "org": "Clinical Medical College,Jiangzhou Hebei ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Clinical Medical College,Jiangzhou Hebei ,China"
            },
            {
                "name": "CHEN Min",
                "org": "Clinical Medical College,Jiangzhou Hebei ,China"
            }
        ],
        "venue": "Laboratory Medicine and Clinic",
        "year": 2010
    },
    "66E7fhLe": {
        "id": "66E7fhLe",
        "title": "Polymorphisms in sodium taurocholate cotransporting polypeptide are not associated with hepatitis B virus clearance in Chinese Tibetans and Uygurs.",
        "abstract": "An association between polymorphisms in the sodium taurocholate cotransporting polypeptide (NTCP) and the natural course of hepatitis B virus (HBV) infection in the Chinese Han population has been noted. However, it is not known whether these polymorphisms are associated with the risk of developing chronic HBV infection in other racial or ethnic populations. Accordingly, we conducted a candidate single nucleotide polymorphism (SNP) association study in Tibetan and Uygur HBV-infected patients. A total of 1302 subjects including 871 Tibetans and 431 Uygurs were recruited. According to their serological and clinical characteristics, each ethnic group was divided into two groups comprising spontaneous clearance individuals and persistently infected patients. Three SNPs were genotyped by a high resolution melting curve methodology. Among the SNPs, rs2296651 exhibited a minor allele frequency of <0.01. The frequency of allele A at rs4646287 was much higher in Tibetans (9.4% for Tibetans and 4.6% for Uygurs, p<0.001) than in Uygurs, but the frequency of allele A at rs7154439 was the opposite (15.7% for Tibetans and 20.5% for Uygurs, p=0.002). Irrespective of race, no significant differences in the frequency distributions of the three SNP alleles or genotypes were observed between the case and clearance groups. Moreover, none of the NTCP haplotypes were statistically different between the two groups. Data from the Tibetan patients could be grouped by HBeAg status, viral load and HBV genotype; however, no significant differences were found in the SNP genotype distribution for each characteristic. In conclusion, the NTCP polymorphisms we identified tended to be ethnicity-dependent. For Tibetans and Uygurs, no association of the three SNPs (rs7154439, rs4646287 and rs2296651) and their haplotypes with HBV chronicity was observed. Examination of SNPs in NTCP for their specific associations with the course of HBV infection in other ethnic minority groups is now required.",
        "keywords": [
            "Chronicity",
            "HBV",
            "Minority",
            "SNP",
            "Sodium taurocholate cotransporting polypeptide"
        ],
        "authors": [
            {
                "name": "Zhenzhen Su",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Yi Li",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Yun Liao",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Bei Cai",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Junlong Zhang",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Lixin Li",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Binwu Ying",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Chuanmin Tao",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Min Zhao",
                "org": "Department of Laboratory Medicine, People's Hospital of Tibet Autonomous Region, Lhasa 850000, China."
            },
            {
                "name": "Zhu Ba",
                "org": "Department of Laboratory Medicine, Tibetan Hospital of Tibet Autonomous Region, Lhasa 850000, China."
            },
            {
                "name": "Zhaoxia Zhang",
                "org": "Center of Laboratory Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumchi, 830054, China."
            },
            {
                "name": "Lanlan Wang",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China."
            }
        ],
        "venue": "Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases",
        "year": 2016
    },
    "Ghl96wPO": {
        "id": "Ghl96wPO",
        "title": "Importance of common TLR2 genetic variants on clinical phenotypes and risk in tuberculosis disease in a Western Chinese population.",
        "abstract": "Our study presented the significant associations of rs3804099 with TB susceptibility in the retreatment TB subgroup analysis. Our study proposed that common TLR2 genetic variants may influence TB development and disease phenotypes in Western Chinese population.",
        "keywords": "",
        "authors": [
            {
                "name": "Jingwei Zhang",
                "org": "Department of Laboratory Medicine, Chengdu Second People's Hospital, Chengdu 610017, PR China."
            },
            {
                "name": "Zhenzhen Zhao",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Huiyu Zhong",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Lijuan Wu",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Wenjing Zhou",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Wu Peng",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Xuejiao Hu",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Jiajia Song",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Tangyuheng Liu",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Qian Wu",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Hao Bai",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Yi Zhou",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Xuerong Chen",
                "org": "Division of Pulmonary Disease, West China Hospital, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Xiaojun Lu",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Binwu Ying",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China. Electronic address: docbwy@126.com."
            }
        ],
        "venue": "Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases",
        "year": 2018
    },
    "6jECfSOO": {
        "id": "6jECfSOO",
        "title": "Multiple genetic variants associated with posttransplantation diabetes mellitus in Chinese Han populations.",
        "abstract": "Recipients with STAT4 (rs7574865) T allele are associated with an increased concentration of IL-1\u03b2, interferon-\u03b3, monocyte chemoattractant protein, and macrophage inflammatory protein-1b. The genetic variants of STAT4 (rs7574865) and IL-18 (rs1946518) may be new important markers for PTDM.",
        "keywords": [
            "PTDM",
            "HLA-DP",
            "HLA-DQ",
            "IL-18",
            "IL-28B",
            "STAT4"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China."
            },
            {
                "name": "Lixin Li",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China."
            },
            {
                "name": "Yunfei An",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China."
            },
            {
                "name": "Junlong Zhang",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China."
            },
            {
                "name": "Yun Liao",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China."
            },
            {
                "name": "Yi Li",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China."
            },
            {
                "name": "Lanlan Wang",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China."
            }
        ],
        "venue": "Journal of clinical laboratory analysis",
        "year": 2018
    },
    "g8nIrDeb": {
        "id": "g8nIrDeb",
        "title": "Association of T-cell immunoglobulin and mucin domain-containing molecule 3 (Tim-3) polymorphisms with susceptibility and disease progression of HBV infection.",
        "abstract": "T-cell immunoglobulin and mucin domain-containing molecule 3 (Tim-3) plays an important role in regulating T cells in hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). However, few researches have reported the association of Tim-3 genetic variants with susceptibility and progression of HBV infection. In this study, we focused on the association of Tim-3 polymorphisms with HBV infection, HBsAg seroclearance and hepatocellular carcinoma.A total of 800 subjects were involved in this study. Four groups were studied here, including HBV, HBsAg seroclearance, HBV-associated HCC and healthy controls. Three single-nucleotide polymorphisms (SNPs) of Tim-3, rs246871, rs25855 and rs31223 were genotyped to analyze the association of Tim-3 polymorphisms with susceptibility and disease progression of HBV infection.Our study found that rs31223 and rs246871 were associated with disease progression of HBV infection, while none of the three SNPs was relevant to HBV susceptibility. The minor allele \"C\" of rs31223 was found to be associated with an increased probability of HBsAg seroclearance (P = 0.033) and genotype \"CC\" of rs246871 to be associated with an increased probability of HBV-associated HCC (P = 0.007). In accordance, haplotypic analysis of the three polymorphisms also showed that the haplotype block CGC* and TGC* were significantly associated with HBsAg seroclearance (P<0.05) while haplotype block CAT*, CGT*, TAC* and TGT* were significantly associated with HBV-associated HCC (all P<0.05).Genetic variants of Tim-3 have an important impact on disease progression of HBV infection. With specific Tim-3 polymorphisms, patients infected with HBV could be potential candidates of HCC and HBsAg seroclearance.",
        "keywords": [
            "biomedical research",
            "bioinformatics"
        ],
        "authors": [
            {
                "name": "Jingyu Liao",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China."
            },
            {
                "name": "Qi Zhang",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China."
            },
            {
                "name": "Yun Liao",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China."
            },
            {
                "name": "Bei Cai",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China."
            },
            {
                "name": "Lixin Li",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China."
            },
            {
                "name": "Lanlan Wang",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China."
            }
        ],
        "venue": "PloS one",
        "year": 2014
    },
    "TJhzgwoq": {
        "id": "TJhzgwoq",
        "title": "TLR1 polymorphisms are significantly associated with the occurrence, presentation and drug-adverse reactions of tuberculosis in Western Chinese adults.",
        "abstract": "We enrolled 646 tuberculosis patients and 475 healthy controls from West China. Six single nucleotide polymorphisms in Toll-like receptor1 gene were genotyped in every individual and were analyzed for their association with tuberculosis susceptibility and clinical presentation. The prospective follow-up was performed to determine whether these single nucleotide polymorphisms are associated with adverse reactions to anti-tuberculosis drugs.",
        "keywords": [
            "Toll-like receptor 1",
            "adverse reactions",
            "anti-TB drugs",
            "single nucleotide polymorphisms",
            "tuberculosis"
        ],
        "authors": [
            {
                "name": "Wu Peng",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, P.R. China."
            },
            {
                "name": "Hao Chen",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, P.R. China."
            },
            {
                "name": "Zhenzhen Zhao",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, P.R. China."
            },
            {
                "name": "Xuejiao Hu",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, P.R. China."
            },
            {
                "name": "Yi Zhou",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, P.R. China."
            },
            {
                "name": "Yingyu Li",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, P.R. China."
            },
            {
                "name": "Lian Yang",
                "org": "Department of Laboratory Medicine, Chengdu Women and Children's Central Hospital, Chengdu 610091, P.R. China."
            },
            {
                "name": "Xuemei Wang",
                "org": "Department of Laboratory Medicine, Chengdu Women and Children's Central Hospital, Chengdu 610091, P.R. China."
            },
            {
                "name": "Jiajia Song",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, P.R. China."
            },
            {
                "name": "Tangyuheng Liu",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, P.R. China."
            },
            {
                "name": "Qian Wu",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, P.R. China."
            },
            {
                "name": "Hao Bai",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, P.R. China."
            },
            {
                "name": "Xiaojun Lu",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, P.R. China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, P.R. China."
            },
            {
                "name": "Binwu Ying",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, P.R. China."
            }
        ],
        "venue": "Oncotarget",
        "year": 2018
    },
    "sSRk2flm": {
        "id": "sSRk2flm",
        "title": "Comparison of Core Needle Biopsy and Excision Specimens for the Accurate Evaluation of Breast Cancer Molecular Markers: a Report of 1003 Cases.",
        "abstract": "In this study, we compared the accuracy of marker evaluation in core needle biopsy (CNB) specimens versus excision specimens (ESs) from breast cancer patients. This retrospective study used data collected from the breast cancer database at the West China Hospital, China. Immunohistochemistry (IHC) results from CNB specimens and ESs were compared, using estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki-67 as markers. Molecular subtyping and endocrine therapy usage correlations based on CNB samples and ESs were evaluated. The results obtained from CNB samples and ESs exhibited substantial agreement for the detection of ER (\u03ba\u00a0=\u00a00.522), PR (\u03ba\u00a0=\u00a00.441), and HER2 (\u03ba\u00a0=\u00a00.451), and also influenced endocrine therapy usage. Fair and poor correlations were observed for Ki-67 staining and molecular subtyping (\u03ba\u00a0=\u00a00.195), respectively. This disagreement might be attributable to a combination of heterogeneity and large tumor size. This study indicates that the discordance rate in molecular marker staining between CNB specimens and ESs is significant enough that results obtained with CNB specimens should be used cautiously or verified using ESs.",
        "keywords": [
            "Breast cancer",
            "Core needle biopsy",
            "HER2",
            "Hormone receptor",
            "Ki-67",
            "Molecular markers"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Department of Breast and Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Zu Wang",
                "org": "Tumor Molecular Laboratory, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Qing Lv",
                "org": "Department of Breast and Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China. hx111cj@126.com."
            },
            {
                "name": "Zhenggui Du",
                "org": "Department of Breast and Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Qiuwen Tan",
                "org": "Department of Breast and Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Di Zhang",
                "org": ""
            },
            {
                "name": "Bingjun Xiong",
                "org": ""
            },
            {
                "name": "Helin Zeng",
                "org": "Department of Breast and Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Juxiang Gou",
                "org": "Department of Breast and Thyroid Surgery, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China."
            }
        ],
        "venue": "Pathology oncology research : POR",
        "year": 2017
    },
    "ZUEZzfML": {
        "id": "ZUEZzfML",
        "title": "Association of the gene polymorphisms in sodium taurocholate cotransporting polypeptide with the outcomes of hepatitis B infection in Chinese Han population.",
        "abstract": "In recent years, sodium taurocholate cotransporting polypeptide (NTCP) was newly identified as a hepatitis B virus (HBV) receptor, which partly shed light on the reason for HBV hepatotropism and its host specificity. However, the related researches were limited to in vitro or animal experiments. Therefore, this study aimed to investigate the association of NTCP polymorphisms with HBV natural course in humans.According to their serological and clinical characteristics, 933 Chinese Han individuals were divided into two major groups, 352 viral clearance controls and 581 persistently infected patients. The latter one included 186 hepatocellular carcinoma (HCC) and 395 non-HCC subjects. A total of five single nucleotide polymorphisms (SNPs) were selected from HapMap dataset and genotyped by high resolution melting (HRM) curve method.The rs7154439 AA genotype was observed slightly more common in viral clearance group than in persistently infected group [16 (4.5%) subjects vs. 10 (1.7%) subjects. p=0.008, adjusted odds ratio (AOR)=0.33, 95% confidence interval (CI)=0.15-0.75 in a codominant model; and p=0.006, AOR=0.32, 95% CI=0.14-0.72 in a recessive model]. While the rs4646287 AA genotype was observed slightly more frequent in HCC group than in non-HCC group [6 (3.2%) subjects vs. 1 (0.3%) subject. p=0.018, AOR=15.74, 95% CI=1.59-155.54 in a codominant model; and p=0.018, AOR=15.91, 95% CI=1.61-157.01 in a recessive model]. There were no statistically significant differences of allele or haplotype distribution between any two groups.This study suggests that polymorphisms in the NTCP region may be associated with the natural course of HBV infection. The rs7154439 AA genotype was associated with HBV clearance, while the rs4646287 AA genotype was associated with HCC occurrence. However, considering the sample size is relatively small, larger studies, especially through multicenter collaboration will be needed to fully validate the significance of these findings.",
        "keywords": [
            "hbv",
            "hrm",
            "hepatocellular carcinoma",
            "snp",
            "sodium taurocholate cotransporting polypeptide"
        ],
        "authors": [
            {
                "name": "Zhenzhen Su",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China."
            },
            {
                "name": "Yi Li",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China."
            },
            {
                "name": "Yun Liao",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China."
            },
            {
                "name": "Bei Cai",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China."
            },
            {
                "name": "Junlong Zhang",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China."
            },
            {
                "name": "Lixin Li",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China."
            },
            {
                "name": "Binwu Ying",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China."
            },
            {
                "name": "Chuanmin Tao",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China."
            },
            {
                "name": "Lanlan Wang",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China."
            }
        ],
        "venue": "Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases",
        "year": 2014
    },
    "NO8Jxw0K": {
        "id": "NO8Jxw0K",
        "title": "Man or machine? Prospective comparison of the version 2018 EASL, LI-RADS criteria and a radiomics model to diagnose hepatocellular carcinoma.",
        "abstract": "In HBV-predominant high-risk patients, the multi-sequence-based MR radiomics signature, v2018 EASL and LI-RADS criteria demonstrated comparable overall accuracies for HCC.",
        "keywords": [
            "Carcinoma",
            "Diagnosis",
            "Gadolinium ethoxybenzyl DTPA",
            "Guideline",
            "Hepatocellular",
            "Machine learning"
        ],
        "authors": [
            {
                "name": "Hanyu Jiang",
                "org": "Department of Radiology, Sichuan University West China Hospital, No. 37 GUOXUE Alley, Chengdu, 610041, Sichuan, China."
            },
            {
                "name": "Xijiao Liu",
                "org": "Department of Radiology, Sichuan University West China Hospital, No. 37 GUOXUE Alley, Chengdu, 610041, Sichuan, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Radiology, Sichuan University West China Hospital, No. 37 GUOXUE Alley, Chengdu, 610041, Sichuan, China."
            },
            {
                "name": "Yi Wei",
                "org": "Department of Radiology, Sichuan University West China Hospital, No. 37 GUOXUE Alley, Chengdu, 610041, Sichuan, China."
            },
            {
                "name": "Jeong Min Lee",
                "org": "Department of Radiology & Institute of Radiation Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea."
            },
            {
                "name": "Likun Cao",
                "org": "Department of Radiology, Sichuan University West China Hospital, No. 37 GUOXUE Alley, Chengdu, 610041, Sichuan, China."
            },
            {
                "name": "Yuanan Wu",
                "org": "Big data research center, University of Electronic Science and Technology of China, No. 2006 XIYUAN Avenue, West Hi-tech Zone, Chengdu, 610000, Sichuan, China."
            },
            {
                "name": "Ting Duan",
                "org": "Department of Radiology, Sichuan University West China Hospital, No. 37 GUOXUE Alley, Chengdu, 610041, Sichuan, China."
            },
            {
                "name": "Xin Li",
                "org": "GE Healthcare, No.1 HUOTUO Road, Zhangjiang Hi-Tech Park, Pudong, Shanghai, 200000, China."
            },
            {
                "name": "Ling Ma",
                "org": "GE Healthcare, No.1 HUOTUO Road, Zhangjiang Hi-Tech Park, Pudong, Shanghai, 200000, China."
            },
            {
                "name": "Bin Song",
                "org": "Department of Radiology, Sichuan University West China Hospital, No. 37 GUOXUE Alley, Chengdu, 610041, Sichuan, China. songlab_radiology@163.com."
            }
        ],
        "venue": "Cancer imaging : the official publication of the International Cancer Imaging Society",
        "year": 2019
    },
    "P0wYHFyJ": {
        "id": "P0wYHFyJ",
        "title": "Association of HLA-DP/DQ and STAT4 polymorphisms with HBV infection outcomes and a mini meta-analysis.",
        "abstract": "Though HLA-DP/DQ is regarded to associate with HBV susceptibility and HBV natural clearance, its role in hepatocellular carcinoma (HCC) development is obscure. And the role of STAT4 in HBV susceptibility and clearance as well as HCC development is still contentious. Therefore, we conducted this study, aiming to clarify these obscure relationships.We recruited 1312 Chinese Han subjects including healthy controls, HBV carriers and HCC patients in the experiment stage. The meta-analysis included 3467 HCC patients and 5821 HBV carriers to appraise the association with HCC development.Consistent with previous studies, HLA-DP/DQ associated with HBV susceptibility and HBV natural clearance (p<0.05). However, the experiment showed that HLA-DP rs3077, rs9277535 and rs7453920 did not associate with HCC development (dominant model, rs3077, OR\u200a=\u200a0.86, 95%CI\u200a=\u200a0.62-1.18; rs9277535, OR\u200a=\u200a0.94, 95%CI\u200a=\u200a0.68-1.30; rs7453920, OR\u200a=\u200a0.75, 95%CI\u200a=\u200a0.44-1.27). Meta-analysis again consolidated this conclusion (allele model, rs3077, OR\u200a=\u200a0.94, 95%CI\u200a=\u200a0.87-1.02; rs9277535, OR\u200a=\u200a1.04, 95%CI\u200a=\u200a0.97-1.11; rs7453920, OR\u200a=\u200a0.89, 95%CI\u200a=\u200a0.76-1.02). As for STAT4 rs7574865, we did not find any significant association with HBV susceptibility (OR\u200a=\u200a0.91, 95%CI\u200a=\u200a0.66-1.26) or HBV natural clearance (OR\u200a=\u200a1.13, 95%CI\u200a=\u200a0.86-1.49). Moreover, current data failed to acquire positive connection of rs7574865 with HCC development (experiment, OR\u200a=\u200a0.86, 95%CI\u200a=\u200a0.62-1.19; meta-analysis, OR\u200a=\u200a0.87, 95%CI\u200a=\u200a0.74-1.03), which may be due to the small sample size.HLA-DP/DQ polymorphisms (rs3077, rs9277535, rs7453920) did not associate with HCC development, but did correlate with HBV susceptibility and HBV natural clearance. STAT4 rs7574865 seemed not to correlate with HBV susceptibility or natural clearance. And it seemed rather ambiguous in its role on HCC development at present.",
        "keywords": [
            "bioinformatics",
            "biomedical research"
        ],
        "authors": [
            {
                "name": "Yun Liao",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China."
            },
            {
                "name": "Bei Cai",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China."
            },
            {
                "name": "Yi Li",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China."
            },
            {
                "name": "Chuanmin Tao",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China."
            },
            {
                "name": "Hengjian Huang",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China."
            },
            {
                "name": "Lanlan Wang",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China."
            }
        ],
        "venue": "PloS one",
        "year": 2014
    },
    "qHPCEErv": {
        "id": "qHPCEErv",
        "title": "Lack of association between interleukin 28B polymorphisms and spontaneous viral clearance in hepatitis B virus patients.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Yun Liao",
                "org": ""
            },
            {
                "name": "Yi Li",
                "org": ""
            },
            {
                "name": "Bei Cai",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Lanlan Wang",
                "org": ""
            }
        ],
        "venue": "Clinical infectious diseases : an official publication of the Infectious Diseases Society of America",
        "year": 2013
    },
    "rmnu9gQk": {
        "id": "rmnu9gQk",
        "title": "Gadoxetic acid-enhanced MRI outperformed MDCT in diagnosing small hepatocellular carcinoma: A meta-analysis",
        "abstract": "Early detection of small hepatocellular carcinoma (HCC) lesions can improve long-term patient survival. A systematic review and meta-analysis of the diagnostic performance of gadoxetic acid disodium-enhanced magnetic resonance imaging (Gd-EOB-DTPA-enhanced MRI) and multidetector computed tomography (MDCT) was performed in diagnosing small HCCs measuring up to 2 cm(\u22642cm). Two investigators searched multiple databases for studies in which the performances of either Gd-EOB-DTPA-enhanced MRI or MDCT were reported with sufficient data to construct 2 \u00d7 2 contingency tables for diagnosing HCCs up to 2 cm on a per-lesion or per-patient level. Diagnostic performances were quantitatively pooled by a bivariate random-effect model with further meta-regression and subgroup analyses. Twenty-seven studies (fourteen on Gd-EOB-DTPA-enhanced MRI, nine on MDCT and four on both) were included, enrolling a total of 1735 patients on Gd-EOB-DTPA-enhanced MRI and 1781 patients on MDCT. Gd-EOB-DTPA-enhanced MRI demonstrated significantly higher overall sensitivity than did MDCT (0.96 vs 0.65, p\uff1c0.01), without substantial loss of specificity (0.98 vs 0.94, pu003e0.05). Area under the summary receiver operating characteristic curve was 0.9712 with Gd-EOB-DTPA-enhanced MRI and 0.8538 with MDCT. Regarding Gd-EOB-DTPA-enhanced MRI, sensitivity was significantly higher for studies from non-Asian countries than Asian countries(0.96 vs 0.93, p\uff1c0.01), for retrospective studies than prospective studies(0.95 vs 0.91, p\uff1c0.01), and for those with Gd-EOB-DTPA injection rate\u22651.5ml/s than that of\uff1c1.5ml/s (0.97 vs 0.90, p\uff1c0.01). Conclusions: Gd-EOB-DTPA-enhanced MRI demonstrated higher sensitivity and overall diagnostic accuracy than MDCT, and thus should be the preferred imaging modality for diagnosing small HCCs measuring up to 2 cm. This article is protected by copyright. All rights reserved.",
        "keywords": "",
        "authors": [
            {
                "name": "Xijiao Liu",
                "org": "Department of RadiologyWest China Hospital, Sichuan UniversityChengdu Sichuan Province China"
            },
            {
                "name": "Hanyu Jiang",
                "org": "Department of RadiologyWest China Hospital, Sichuan UniversityChengdu Sichuan Province China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of RadiologyWest China Hospital, Sichuan UniversityChengdu Sichuan Province China"
            },
            {
                "name": "You Zhou",
                "org": ""
            },
            {
                "name": "Zixing Huang",
                "org": "Department of RadiologyWest China Hospital, Sichuan UniversityChengdu Sichuan Province China"
            },
            {
                "name": "Bin Song",
                "org": "Department of RadiologyWest China Hospital, Sichuan UniversityChengdu Sichuan Province China"
            }
        ],
        "venue": "Liver Transplantation",
        "year": 2017
    },
    "taC2MugY": {
        "id": "taC2MugY",
        "title": "Weekly taxane\u2013anthracycline combination regimen versus tri-weekly anthracycline-based regimen for the treatment of locally advanced breast cancer: a randomized controlled trial",
        "abstract": "Extensive studies have confirmed the efficacy of taxanes in combination with anthracycline-based chemotherapy on breast cancer. However, few studies have assessed the efficacy of weekly taxane\u2013anthracycline regimens on locally advanced breast cancer. This study was to compare the efficacy and safety of a weekly taxane\u2013anthracycline regimen with those of tri-weekly anthracycline-based regimen in patients with locally advanced breast cancer. Patients with locally advanced breast cancer were randomized to receive 4\u20136 cycles of neoadjuvant chemotherapy with tri-weekly 5-fluorouracil\u2013epirubicin\u2013cyclophosphamide (FEC) regimen or weekly paclitaxel\u2013epirubicin (PE) regimen. The primary endpoint was the pathologic complete response (pCR) rate. Other endpoints included the clinical tumor response, breast-conserving surgery rate, and adverse events. Between March 2010 and September 2013, 293 patients were randomized to the FEC (n\u00a0=\u00a0151) and PE (n\u00a0=\u00a0142) arms. The overall clinical response rate was significantly higher in the PE arm than in the FEC arm (76.06% vs. 59.95%, P\u00a0=\u00a00.001). Consistently, the post-chemotherapy pathologic T and N stages were significantly lower in the PE arm than in the FEC arm (P\u00a0u003c\u00a00.001). However, the pCR rate was similar in the two arms (10.61% vs. 12.31%, P\u00a0=\u00a00.665). Overall, 36 (27.27%) patients in the FEC arm and 6 (35.28%) in the PE arm were qualified for breast-conserving surgery. Most adverse events were comparable in both arms, with more severe neutropenia in the PE arm than in the FEC arm (11.97% vs. 5.96%, P\u00a0=\u00a00.031). In patients with locally advanced breast cancer, weekly PE was not superior to FEC in terms of pCR. However, weekly PE has a higher response rate and superior down-staging effects. On this account, the PE regimen may be considered an alternative option for locally advanced breast cancer. Long-term follow-up data are needed to confirm the efficacy of this regimen on locally advanced breast cancer.                            Trial registration Chinese clinical trial registry, ChiCTR-TRC-10001043, September 21, 2014",
        "keywords": "",
        "authors": [
            {
                "name": "Qiu-Wen Tan",
                "org": "Department of Breast Surgery, West China Hospital, Sichuan University, Chengdu, P. R. China"
            },
            {
                "name": "Ting Luo",
                "org": "Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, P. R. China"
            },
            {
                "name": "Hong Zheng",
                "org": "Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, P. R. China"
            },
            {
                "name": "Ting-Lun Tian",
                "org": "Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, P. R. China"
            },
            {
                "name": "Ping He",
                "org": "Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, P. R. China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Breast Surgery, West China Hospital, Sichuan University, Chengdu, P. R. China"
            },
            {
                "name": "He-Lin Zeng",
                "org": "Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, P. R. China"
            },
            {
                "name": "Qing Lv",
                "org": "Department of Breast Surgery, West China Hospital, Sichuan University, Chengdu, P. R. China"
            }
        ],
        "venue": "Chinese Journal of Cancer",
        "year": 2017
    },
    "qgfB7tuz": {
        "id": "qgfB7tuz",
        "title": "Chemotherapy-associated lipid changes in breast cancer patients: A retrospective analysis from a high-volume institution in China.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Tao He",
                "org": "Department of Breast Surgery, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China;"
            },
            {
                "name": "Qing Lv",
                "org": "West China Hospital of Sichuan University, Chengdu, China;"
            },
            {
                "name": "Yunhao Wu",
                "org": "Department of Breast Surgery, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China;"
            },
            {
                "name": "Yuan Fan",
                "org": "Department of Breast Surgery, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China;"
            },
            {
                "name": "Jie Chen",
                "org": "West China Hospital of Sichuan University, Chengdu, China;"
            }
        ],
        "venue": "Journal of Clinical Oncology",
        "year": 2019
    },
    "ig8qF939": {
        "id": "ig8qF939",
        "title": "Quantitative free-breathing dynamic contrast-enhanced MRI in hepatocellular carcinoma using gadoxetic acid: correlations with Ki67 proliferation status, histological grades, and microvascular density.",
        "abstract": "To validate a free-breathing dynamic contrast-enhanced-MRI (DCE-MRI) in hepatocellular carcinoma (HCC) patients using gadoxetic acid, and to determine the relationship between DCE-MRI parameters and histological results.Thirty-four HCC patients were included in this prospective study. Free-breathing DCE-MRI data was acquired preoperatively on a 3.0 Tesla scanner. Perfusion parameters (K (trans), K ep, V e and the semi-quantitative parameter of initial area under the gadolinium concentration-time curve, iAUC) were calculated and compared with tumor enhancement at contrast-enhanced CT. The relationship between DCE-MRI parameters and Ki67 indices, histological grades and microvascular density (MVD) was determined by correlation analysis. Differences of perfusion parameters between different histopathological groups were compared. Receiver operation characteristic (ROC) analysis of discriminating high-grades (grade III and IV) from low-grades (grade I and II) HCC was performed for perfusion parameters.Significant relationship was found between DCE-MRI and CT results. The DCE-MRI derived K (trans) were significantly negatively correlated with Ki-67 indices (rho = - 0.408, P = 0.017) and the histological grades (rho = - 0.444, P = 0.009) of HCC, and K ep and V e were significantly related with tumor MVD (rho = - 0.405, P = 0.017 for K ep; and rho = 0.385, P = 0.024 for V e). K (trans), K ep, and iAUC demonstrated moderate diagnostic performance (iAUC = 0.78, 0.77 and 0.80, respectively) for discriminating high-grades from low-grades HCC without significant differences.The DCE-MRI derived parameters demonstrated weak but significant correlations with tumor proliferation status, histological grades or microvascular density, respectively. This free-breathing DCE-MRI is technically feasible and offers a potential avenue toward non-invasive evaluation of HCC malignancy.",
        "keywords": [
            "Dynamic contrast-enhanced magnetic resonance imaging",
            "Hepatocellular carcinoma",
            "Ki-67 proliferation",
            "Histological grade",
            "Microvascular density"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "West China Medical School of Sichuan University, Chengdu, 610041, Sichuan, China."
            },
            {
                "name": "Chenyang Chen",
                "org": "Department of Radiology, West China Hospital of Sichuan University, Guoxuexiang No. 37, Chengdu, 610041, Sichuan province, China."
            },
            {
                "name": "Chunchao Xia",
                "org": "Department of Radiology, West China Hospital of Sichuan University, Guoxuexiang No. 37, Chengdu, 610041, Sichuan province, China."
            },
            {
                "name": "Zixing Huang",
                "org": "Department of Radiology, West China Hospital of Sichuan University, Guoxuexiang No. 37, Chengdu, 610041, Sichuan province, China."
            },
            {
                "name": "Panli Zuo",
                "org": "MR Collaboration NE Asia, Siemens Healthcare, Beijing, 100000, China."
            },
            {
                "name": "Alto Stemmer",
                "org": "Siemens Healthcare, 91052, Erlangen, Germany."
            },
            {
                "name": "Bin Song",
                "org": "Department of Radiology, West China Hospital of Sichuan University, Guoxuexiang No. 37, Chengdu, 610041, Sichuan province, China. songb_radiology@163.com."
            }
        ],
        "venue": "Abdominal radiology (New York)",
        "year": 2017
    },
    "DgzhCdvH": {
        "id": "DgzhCdvH",
        "title": "Erratum: Corrigendum: Epidemiology study of HBV genotypes and antiviral drug resistance in multi-ethnic regions from Western China",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Qi Zhang",
                "org": ""
            },
            {
                "name": "Yun Liao",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Bei Cai",
                "org": ""
            },
            {
                "name": "Zhenzhen Su",
                "org": ""
            },
            {
                "name": "Binwu Ying",
                "org": ""
            },
            {
                "name": "Xiaojun Lu",
                "org": ""
            },
            {
                "name": "Chuanmin Tao",
                "org": ""
            }
        ],
        "venue": "Scientific Reports",
        "year": 2016
    },
    "pN2xVJND": {
        "id": "pN2xVJND",
        "title": "Texture analysis on gadoxetic acid enhanced-MRI for predicting Ki-67 status in hepatocellular carcinoma: A prospective study.",
        "abstract": "Texture analysis on gadoxetic acid enhanced MRI can serve as a noninvasive approach to preoperatively predict Ki-67 status of HCC after curative resection. The combination of texture signature and clinical factors demonstrated the potential to further improve the prediction performance.",
        "keywords": [
            "Hepatocellular carcinoma",
            "Ki-67",
            "MRI",
            "radiomics",
            "texture analysis"
        ],
        "authors": [
            {
                "name": "Zheng Ye",
                "org": "West China School of Medicine, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Hanyu Jiang",
                "org": "West China School of Medicine, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Jie Chen",
                "org": "West China School of Medicine, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Xijiao Liu",
                "org": "Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Yi Wei",
                "org": "West China School of Medicine, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Chunchao Xia",
                "org": "Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Ting Duan",
                "org": "Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Likun Cao",
                "org": "West China School of Medicine, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Zhen Zhang",
                "org": "West China School of Medicine, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Bin Song",
                "org": "Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China."
            }
        ],
        "venue": "Chinese journal of cancer research = Chung-kuo yen cheng yen chiu",
        "year": 2019
    },
    "MwDfH3V8": {
        "id": "MwDfH3V8",
        "title": "Circulating microRNAs as potential biomarkers of HBV infection persistence.",
        "abstract": "To investigate different microRNA (miRNA) expression profile in patients of hepatitis B virus (HBV) infection compared with virus spontaneous clearance ones, and try to find new biomarker for diagnosis and treatment assessment.miRNA expression profiling was analyzed in patients with HBV infection and patients with virus spontaneous clearance by Affymetrix Gene Chip miRNA 4.0 Arrays. The differently expressed miRNAs, as verified by RT-PCR, were analyzed and compared with each other in the two groups of patients.Significant difference was found in the expression of miR-29b, miR-34, miR-4485, miR-3180, miR-125, miR-330-3p, miR-1468 in spontaneous clearance group and CHB group. miR-29b, miR-34, miR-4485 was significantly increased in CHB group, while miR-125, miR-330-3p, miR-1468, miR-3180 was significantly decreased. Correlation analysis indicate only miR-29b was positive correlation with HBsAg.These results indicated above miRNAs may be associated with HBV infection persistence, and provided us new ideas for finding potential biomarkers.",
        "keywords": [
            "Biomarker",
            "CHB",
            "MicroRNA",
            "Spontaneous clearance"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Xiaojuan Wu",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Bei Cai",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Zhenzhen Su",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Lixin Li",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Yunfei An",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Lanlan Wang",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China."
            }
        ],
        "venue": "Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases",
        "year": 2017
    },
    "EvqQ5Opa": {
        "id": "EvqQ5Opa",
        "title": "Association of HLA-DP/DQ, STAT4 and IL-28B variants with HBV viral clearance in Tibetans and Uygurs in China.",
        "abstract": "Several genome-wide association studies have revealed that HLA-DP/DQ, STAT4 and IL-28B associated with liver diseases. But because of population heterogeneity, different races would have different causative polymorphisms. Therefore, in this study, we included Chinese Tibetans and Uygurs to examine the roles of these genes on HBV natural clearance.A total of 1341 subjects including 908 Tibetans and 433 Uygurs were recruited. Seven single nucleotide polymorphisms (SNP) were genotyped.HLA-DP/DQ polymorphisms associated with HBV natural clearance in both ethnicities (Tibetans, rs3077, OR = 0.61, 95% CI = 0.46-0.82; rs9277535, OR = 0.56, 95% CI = 0.41-0.75; rs7453920, OR = 0.64, 95%CI = 0.47-0.85; Uygurs, rs3077, OR = 0.48, 95% CI = 0.24-0.96; rs9277535, OR = 0.43, 95% CI = 0.20-0.91; rs7453920, OR = 0.62, 95% CI = 0.39-0.99), whereas no significant association was observed between IL-28B with HBV natural clearance in neither ethnicities (P > 0.05). STAT4 rs7574865 seemed to be Tibetan specific in HBV natural clearance (OR = 0.76, 95% CI = 0.58-0.99). Moreover, in Tibetan patients, HLA-DQ rs7453920 GG had a higher frequency in HBeAg positive patients (P = 0.032) and STAT4 rs7574865 GG genotype appeared more frequently in Genotype C virus infected patients (P = 0.005). In addition, Uygurs have higher frequencies of HLA-DP/DQ protective alleles (72.5% for rs3077, 76.6% for rs9277535 and 26.8% for rs7453920) than Tibetans (51.7% for rs3077, 52.5% for rs9277535 and 18.5% for rs7453920)(all P < 0.05), and a lower prevalence of HBV infection as previously reported.HLA-DP/DQ but not IL-28B polymorphisms correlate with HBV natural clearance, irrespective of race, and HLA-DP/DQ would be causative genes attributing to varying prevalence in different regions. STAT4 rs7574865 seemed to be population specific in Tibetans and it might synergistically interact with virus contributing to disease progression.",
        "keywords": [
            "hbv",
            "hla-dp/dq",
            "il-28b",
            "stat4",
            "tibetan",
            "uygur"
        ],
        "authors": [
            {
                "name": "Yun Liao",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China."
            },
            {
                "name": "Bei Cai",
                "org": ""
            },
            {
                "name": "Yi Li",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Binwu Ying",
                "org": ""
            },
            {
                "name": "Chuanmin Tao",
                "org": ""
            },
            {
                "name": "Min Zhao",
                "org": ""
            },
            {
                "name": "Zhu Ba",
                "org": ""
            },
            {
                "name": "Zhaoxia Zhang",
                "org": ""
            },
            {
                "name": "Lanlan Wang",
                "org": ""
            }
        ],
        "venue": "Liver international : official journal of the International Association for the Study of the Liver",
        "year": 2015
    },
    "gDdzevgp": {
        "id": "gDdzevgp",
        "title": "[Diagnostic Performance of Susceptibility-weighted Imaging in the Grading of Hepatocellular Carcinoma].",
        "abstract": "ITSS of SWI had the potential to differentiate HCC grades.",
        "keywords": [
            "Hepatocellular carcinoma",
            "Magnetic resonance imaging",
            "Pathology",
            "Susceptibility-weighted imaging"
        ],
        "authors": [
            {
                "name": "Ting Duan",
                "org": "Department of Radiology,West China Hospital,Sichuan University,Chengdu 610041,China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Radiology,West China Hospital,Sichuan University,Chengdu 610041,China."
            },
            {
                "name": "Chun-Chao Xia",
                "org": "Department of Radiology,West China Hospital,Sichuan University,Chengdu 610041,China."
            },
            {
                "name": "Bin Song",
                "org": "Department of Radiology,West China Hospital,Sichuan University,Chengdu 610041,China."
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2018
    },
    "3wGU2thU": {
        "id": "3wGU2thU",
        "title": " Noninvasive prediction of HCC with progenitor phenotype based on gadoxetic acid-enhanced MRI.",
        "abstract": "\u2022 Qualitative image features of irregular tumor margin, targetoid appearance, and the absence of mosaic architecture are significant predictors of hepatocellular carcinoma with progenitor phenotype. \u2022 Quantitative analyses using whole-lesion histogram analysis provides additional information for the prediction of hepatocellular carcinoma with progenitor phenotype. \u2022 Noninvasive prediction of hepatocellular carcinoma with progenitor phenotype can be achieved with high accuracy by integrated interpretation of clinical information and qualitative and quantitative imaging analyses.",
        "keywords": [
            "Cytokeratin 19",
            "Epithelial cell adhesion molecule",
            "Hepatocellular carcinoma",
            "Magnetic resonance imaging",
            "Nomogram"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "West China School of Medicine, Sichuan University, Guoxue Xiang, No. 37, Chengdu, 610041, China."
            },
            {
                "name": "Zhenru Wu",
                "org": "Laboratory of Pathology, West China Hospital, Sichuan University, B2 Building, No. 88, South Ke Yuan Road, Chengdu, 610041, China."
            },
            {
                "name": "Chunchao Xia",
                "org": "Department of Radiology, West China Hospital, Sichuan University, Guoxue Xiang, No. 37, Chengdu, 610041, China."
            },
            {
                "name": "Hanyu Jiang",
                "org": "West China School of Medicine, Sichuan University, Guoxue Xiang, No. 37, Chengdu, 610041, China."
            },
            {
                "name": "Xijiao Liu",
                "org": "Department of Radiology, West China Hospital, Sichuan University, Guoxue Xiang, No. 37, Chengdu, 610041, China."
            },
            {
                "name": "Ting Duan",
                "org": "Department of Radiology, West China Hospital, Sichuan University, Guoxue Xiang, No. 37, Chengdu, 610041, China."
            },
            {
                "name": "Likun Cao",
                "org": "West China School of Medicine, Sichuan University, Guoxue Xiang, No. 37, Chengdu, 610041, China."
            },
            {
                "name": "Zheng Ye",
                "org": "West China School of Medicine, Sichuan University, Guoxue Xiang, No. 37, Chengdu, 610041, China."
            },
            {
                "name": "Zhen Zhang",
                "org": "West China School of Medicine, Sichuan University, Guoxue Xiang, No. 37, Chengdu, 610041, China."
            },
            {
                "name": "Ling Ma",
                "org": "Application Advanced Team, GE Healthcare, Shanghai, China."
            },
            {
                "name": "Bin Song",
                "org": "Department of Radiology, West China Hospital, Sichuan University, Guoxue Xiang, No. 37, Chengdu, 610041, China. songlab_radiology@163.com."
            },
            {
                "name": "Yujun Shi",
                "org": "Laboratory of Pathology, West China Hospital, Sichuan University, B2 Building, No. 88, South Ke Yuan Road, Chengdu, 610041, China. shiyujun@scu.edu.cn."
            }
        ],
        "venue": "European radiology",
        "year": 2019
    },
    "6guq8Pw0": {
        "id": "6guq8Pw0",
        "title": "Prediction of ovarian function in premenopausal breast cancer patients with amenorrhoea after chemotherapy: a simple clinical score.",
        "abstract": "We evaluated a non-invasive method for predicting the ovarian function of premenopausal breast cancer patients with amenorrhoea after chemotherapy. A total of 34 patients had ovarian function, whereas 56 had no ovarian function. Logistic regression analysis indicated that age (P\u00a0=\u00a00.034; hazards ratio [HR], 0.29; confidence interval [CI], 0.091-0.910), follicle-stimulating hormone (P\u00a0=\u00a00.032; HR 0.97; CI 0.944-0.997) and oestradiol (P\u00a0=\u00a00.047; HR 1.01; CI 1.000-1.015) were independent influencing factors that determine ovarian function. The ovarian function score (OFS) (P\u00a0<\u00a00.001; HR 48.00; CI 10.174-226.452) was obtained through a comprehensive analysis of these three variables, and it could more effectively predict ovarian function. According to receiver operating characteristic curve analysis, the OFS had the highest values compared with the other three variables (sensitivity, 94.6\u00a0%; specificity, 79.3\u00a0%). The OFS is simple and easy to use; thus, it is expected to become a new method for determining drug-induced amenorrhoea in women with breast cancer. Ovarian function likely still exists if the OFS is \u22641. ",
        "keywords": [
            "Amenorrhoea",
            "Breast cancer",
            "Ovarian function",
            "Ovariectomy",
            "Sex hormone"
        ],
        "authors": [
            {
                "name": "Xiao Shi Li",
                "org": "Department of Thyroid and Breast Surgery, West China Hospital of Sichuan University, Guo xue Lane 37, Chengdu, China."
            },
            {
                "name": "Qing Lv",
                "org": "Department of Thyroid and Breast Surgery, West China Hospital of Sichuan University, Guo xue Lane 37, Chengdu, China."
            },
            {
                "name": "Zheng Gui Du",
                "org": "Department of Thyroid and Breast Surgery, West China Hospital of Sichuan University, Guo xue Lane 37, Chengdu, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Thyroid and Breast Surgery, West China Hospital of Sichuan University, Guo xue Lane 37, Chengdu, China."
            }
        ],
        "venue": "SpringerPlus",
        "year": 2016
    },
    "BBNNOLNi": {
        "id": "BBNNOLNi",
        "title": "No Significant Effect of ASAP1 Gene Variants on the Susceptibility to Tuberculosis in Chinese Population.",
        "abstract": "Recent studies have proposed that the ASAP1 gene participates in regulating the adaptive immune response to Mycobacterium tuberculosis infection. A GWAS study has reported that ASAP1 polymorphisms (rs4733781 and rs10956514) were associated with the risk of tuberculosis (TB) in Russians. But due to population heterogeneity, different races would have different causative polymorphisms, and the aim of this study was to investigate the association between single nucleotide polymorphisms (SNPs) of the ASAP1 gene and TB risk in Chinese population.A total of 7 SNPs in the ASAP1 gene were genotyped in 1115 Western Chinese Han and 914 Tibetan population using an improved multiplex ligation detection reaction (iMLDR) method. The associations of SNPs with TB risk and clinical phenotypes were determined based on the distributions of allelic frequencies and different genetic models. A meta-analysis was carried out to further assess the relationship between ASAP1 polymorphism and TB risk.Statistical comparisons of cases and controls after correction for multiple testing did not yield any significant associations with the risk of TB via analyses of a single locus, haplotype, and subgroup differences. Meta-analysis showed no evidence supporting association between rs10956514 and overall risk for TB. Subsequent analysis referring to the genotypes of SNPs in relationship to clinical phenotypes identified that rs4236749 was associated with different serum C-reactive protein levels, suggesting a role of this locus in influencing the inflammatory state of Western Chinese Han patients with TB.Our present data revealed that ASAP1 polymorphisms are unlikely to confer susceptibility to TB in the Western Chinese Han and Tibetan populations, which challenges the promising roles of the ASAP1 gene in the development of TB and highlights the importance of validating the association findings across ethnicities.",
        "keywords": "",
        "authors": [
            {
                "name": "Xuejiao Hu",
                "org": "From the Department of Laboratory Medicine (XH, WP, ZZ, JZhang, JZhou, BC, JC, YZ, XL, BY) and Division of Tuberculosis (XC), West China Hospital, Sichuan University, Chengdu, P.R. China."
            },
            {
                "name": "Wu Peng",
                "org": ""
            },
            {
                "name": "Xuerong Chen",
                "org": ""
            },
            {
                "name": "Zhenzhen Zhao",
                "org": ""
            },
            {
                "name": "Jingya Zhang",
                "org": ""
            },
            {
                "name": "Juan Zhou",
                "org": ""
            },
            {
                "name": "Bei Cai",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Yanhong Zhou",
                "org": ""
            },
            {
                "name": "Xiaojun Lu",
                "org": ""
            },
            {
                "name": "Binwu Ying",
                "org": ""
            }
        ],
        "venue": "Medicine",
        "year": 2016
    },
    "OnoKurbY": {
        "id": "OnoKurbY",
        "title": "Imaging evaluation of sorafenib for treatment of advanced hepatocellular carcinoma.",
        "abstract": "Sorafenib, which is a novel targeted agent, plays an important role in treating advanced hepatocellular carcinoma (HCC) through its antiangiogenic and antiproliferative effects. However, conventional morphology-based radiographic evaluation systems may underestimate the efficacy of sorafenib in HCC due to a lack of apparent tumor shrinkage or altered tumor morphology in many cases. This calls for the development of more accurate imaging methods for evaluating sorafenib. The introduction of tumor burden measurements based on viability and other evolving imaging approaches for assessing therapeutic effects are promising for overcoming some of the limitations of the morphology-based criteria. In this review, we summarize various imaging methods that are used to assess treatment responses of advanced HCC to sorafenib. Imaging markers predictive of prognosis in advanced HCC after treatment with sorafenib are also included and discussed.",
        "keywords": [
            "Hepatocellular carcinoma",
            "computed tomography",
            "magnetic resonance imaging",
            "sorafenib"
        ],
        "authors": [
            {
                "name": "Tianying Zheng",
                "org": "Department of Radiology, Sichuan University West China Hospital, Chengdu 610041, China."
            },
            {
                "name": "Hanyu Jiang",
                "org": "Department of Radiology, Sichuan University West China Hospital, Chengdu 610041, China."
            },
            {
                "name": "Yi Wei",
                "org": "Department of Radiology, Sichuan University West China Hospital, Chengdu 610041, China."
            },
            {
                "name": "Zixing Huang",
                "org": "Department of Radiology, Sichuan University West China Hospital, Chengdu 610041, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Radiology, Sichuan University West China Hospital, Chengdu 610041, China."
            },
            {
                "name": "Ting Duan",
                "org": "Department of Radiology, Sichuan University West China Hospital, Chengdu 610041, China."
            },
            {
                "name": "Bin Song",
                "org": "Department of Radiology, Sichuan University West China Hospital, Chengdu 610041, China."
            }
        ],
        "venue": "Chinese journal of cancer research = Chung-kuo yen cheng yen chiu",
        "year": 2018
    },
    "qvnLZD8e": {
        "id": "qvnLZD8e",
        "title": "Association of three SNPs in interleukin-28B with graft hepatic dysfunction after liver transplantation in Chinese Han population.",
        "abstract": "Recurrent graft infection limited the effect of LT, early recognition and prophylaxis of HBV recurrence are very important, and interleukin 28B (IL\u201028B) gene was reported to be associated with HBV infection.To explore the association between IL-28B single-nucleotide polymorphisms (SNPs) and graft re-infection after liver transplantation(LT).21 recipients with hepatitis B virus(HBV) recurrence and 157 recipients without HBV recurrence were included. We studied three SNPs in the promoter region of IL-28B gene at the positions rs12979860,rs12980275 and rs8099917 by HRM analysis (high-resolution melting curve analysis).Hepatic allograft dysfunction was more likely to be associated with IL-28B SNPs. However, there was no significant difference in the frequencies of IL-28B gene distribution in recipients with or without HBV recurrence.IL-28B gene polymorphism may be associated with the prognosis of LT recipients but it needs more experiments.",
        "keywords": [],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Yi Li",
                "org": ""
            },
            {
                "name": "Lanlan Wang",
                "org": ""
            },
            {
                "name": "Yang Fu",
                "org": ""
            },
            {
                "name": "Yun Liao",
                "org": ""
            },
            {
                "name": "Junlong Zhang",
                "org": ""
            }
        ],
        "venue": "Gene",
        "year": 2012
    },
    "uTJuwyWK": {
        "id": "uTJuwyWK",
        "title": "Correlation of CpG methylation of Pdcd1 gene with PD-1 expression on CD8 + T cells and medical laboratory indicators in chronic hepatitis B infection.",
        "abstract": "Our study suggests that Pdcd1 methylation is correlated with PD-1 expression on CD8 T cells and correlated with HBsAg and alanine aminotransferase (ALT). The results may provide new ideas of anti-PD-1 inhibitors and the epigenetic regulators such as demethylation inhibitors could be more successful therapeutic strategies in hepatitis B infection patients.",
        "keywords": [
            "Pdcd1",
            "Programmed death-1",
            "chronic hepatitis B infection",
            "methylation"
        ],
        "authors": [
            {
                "name": "Lin Jiao",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, P. R. China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, P. R. China."
            },
            {
                "name": "Xiaojuan Wu",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, P. R. China."
            },
            {
                "name": "Bei Cai",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, P. R. China."
            },
            {
                "name": "Zhenzhen Su",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, P. R. China."
            },
            {
                "name": "Lanlan Wang",
                "org": "Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, P. R. China."
            }
        ],
        "venue": "The journal of gene medicine",
        "year": 2019
    },
    "AK1x3NfY": {
        "id": "AK1x3NfY",
        "title": "Liver fibrosis staging with diffusion-weighted imaging: a systematic review and meta-analysis",
        "abstract": "PurposeA meta-analysis was performed to assess the diagnostic performance of diffusion-weighted imaging (DWI) in liver fibrosis (LF) staging.",
        "keywords": [
            "Diffusion magnetic resonance imaging",
            "Liver cirrhosis",
            "Sensitivity",
            "Specificity",
            "Meta-analysis"
        ],
        "authors": [
            {
                "name": "Hanyu\u00a0Jiang",
                "org": "Department of Radiology,Sichuan University West China Hospital,Chengdu,China"
            },
            {
                "name": "Jie\u00a0Chen",
                "org": "Department of Radiology,Sichuan University West China Hospital,Chengdu,China"
            },
            {
                "name": "Ronghui\u00a0Gao",
                "org": "Department of Radiology,Sichuan University West China Hospital,Chengdu,China"
            },
            {
                "name": "Zixing\u00a0Huang",
                "org": "Department of Radiology,Sichuan University West China Hospital,Chengdu,China"
            },
            {
                "name": "Mingpeng\u00a0Wu",
                "org": "Department of Radiology,Sichuan University West China Hospital,Chengdu,China"
            },
            {
                "name": "Bin\u00a0Song",
                "org": "Department of Radiology,Sichuan University West China Hospital,Chengdu,China"
            }
        ],
        "venue": "Abdominal Radiology",
        "year": 2017
    },
    "WDRlu5VU": {
        "id": "WDRlu5VU",
        "title": "Correlation of coagulation indicators with inflammatory markers for sepsis in the patients with hematological malignancies]",
        "abstract": "This study was aimed to investigate the correlation of coagulation indicators [prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (FIB), antithrombinIII (ATIII), D-dimer (D-D) levels] with inflammatory markers [procalcitonin (PCT), C reactive protein (CRP), interleukin-6 (IL-6), serum amyloid A (SAA)] for sepsis in hematologic malignancy patients. A total of 326 febrile in patients with hematologic diseases from 2062 patients in West China Hospital, Sichuan University from March 2011 to April 2013 were retrospectively analyzed. The patients were divided into sepsis group(n = 72), non-sepsis group(n = 176) and non-sepsis with low Alb group (n = 78) according to blood culture. The results showed that the values of PT, APTT, D-dimer, Plt in sepsis group were higher than those in non-sepsis group, and the difference between them was statistically significant. While the ATIII level in the sepsis group was lower than that in non-sepsis group, and the difference between them was statistically significant (P < 0.05). And the four inflammatory biomarkers in the sepsis patients were higher than those in non-sepsis patients (P < 0.05). TT and FIB level were not significantly different (P > 0.05). There was not a significant difference in these indicators between non-sepsis group and non-sepsis with low Alb group. The correlation analysis suggested that the level of PCT positively correlated with APTT, D-dimer level (P < 0.05); and negatively correlated with the ATIII (P < 0.05). It is concluded that sepsis results in the concurrent activation of inflammatory and procoagulant pathways. The hematologic malignancy patients with sepsis have an obviously higher systemic inflammatory response, and accompanied with coagulation dysfunction.",
        "keywords": [],
        "authors": [
            {
                "name": "Yang Fu",
                "org": "Department of Laboratorial Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China."
            },
            {
                "name": "Hong Jiang",
                "org": "Department of Laboratorial Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China. E-mail: jianghongscu@126.com."
            },
            {
                "name": "Li-Xin Li",
                "org": "Department of Laboratorial Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Laboratorial Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China."
            },
            {
                "name": "Qian Niu",
                "org": "Department of Laboratorial Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China."
            },
            {
                "name": "Ruo-Xu Li",
                "org": "Department of Clinical Laboratorial Medicine, West China Clinical Medical College, Sichuan University, Chengdu 610041,Sichuan Province, China."
            }
        ],
        "venue": "Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology",
        "year": 2014
    },
    "qVgrjs1J": {
        "id": "qVgrjs1J",
        "title": "Roles of Fas, caspase-3, and anti-nucleosome antibodies in apoptosis imbalance of lymphocytes in patients with systemic lupus erythematosus",
        "abstract": "Objective To explore the relationship between immune dysfunction and disturbance of lymphocytic apoptosis signal transduction pathway in patients with systemic lupus erythematosus (SLE). Methods Flow cytometry was used to determine the expression rates of membrane Fas, FasL, and activated intracellular caspase-3 in lymphocytes, and determine the percentage of apoptotic cells (AnnexinV positive, PI negative) and necrotic cells (AnnexinV positive, PI positive). The serum concentrations of anti-nucleosome antibodies were assayed by ELISA. Results Compared with health control group, the percentages of apoptotic cells and necrotic cells enhanced in patients with inactive or active SLE (P < 0.05), and the expression rates of Fas, FasL, and activated caspase-3 significantly increased in patients with inactive or active SLE (P < 0.05). Compared with inactive SLE group, the percentage of apoptotic cells and necrotic cells enhanced in patients with active SLE, but only the increase of necrotic cells was significant (P < 0.05). There was no obvious difference of expression rates of Fas, FasL, and activated caspase-3 of lymphocytes between the two disease groups (P > 0.05). The serum concentration of anti-nucleosome antibodies was strikingly higher in patients with active SLE than those in inactive SLE patients and health control group. The percentage of apoptotic cells and the expression rate of activated caspase-3 were negatively correlated with the concentration of complement 3 in SLE patients. Conclusion Fas-mediated signal pathway plays an important role in apoptosis imbalance of lymphocytes in patients with SLE. The activation of caspase-3 in lymphocytes is a crucial feature of lymphocytic apoptosis activation. The degree of apoptosis activation of lymphocytes is correlated with disease activity and immune response dysfunction. The degree of lymphocytic apoptosis imbalance is associated with the level of anti-nucleosome antibodies. Acceleration of lymphocytic apoptosis plays an important role in immune pathologic injury and immune regulation dysfunction.",
        "keywords": [
            "Anti-nucleosome antibody",
            "Fas",
            "FasL",
            "Systemic lupus erythematosus",
            "Activated caspase-3"
        ],
        "authors": [
            {
                "name": "CHEN Xue",
                "org": "Division of Clinical Immunological Laboratory, Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu , China"
            },
            {
                "name": "WANG Lan-lan",
                "org": "Division of Clinical Immunological Laboratory, Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu , China"
            },
            {
                "name": "CAI Bei",
                "org": "Division of Clinical Immunological Laboratory, Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu , China"
            },
            {
                "name": "CHEN Jie",
                "org": "Division of Clinical Immunological Laboratory, Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu , China"
            },
            {
                "name": "FENG Wei-hua",
                "org": "Division of Clinical Immunological Laboratory, Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu , China"
            }
        ],
        "venue": "Immunological Journal",
        "year": 2006
    },
    "K0uMpqJ2": {
        "id": "K0uMpqJ2",
        "title": "Relationship of apoptosis and costimulators of T lymphocytes with cellular immune function in patients with end-stage renal failure",
        "abstract": "Objective:To explore the relationship of expressions of apoptotic receptor CD95 and costimulators of CD28/CD152 (CTLA-4) on T lymphocytic subpopulations with cellular immune in patients with end-stage renal failure(ESRF). Methods:To apply flow cytometry to determine expressions of CD95 and CD28/CD152( CTLA-4) on T cell subsets in patients with ESRF. Results:In comparison between patients group and control group,CD3+T cells and CD4+T cells strikingly increase in patients,the ratio of CD4 and CD8 is increasing(P =0.008) expressions of CD95 on both of CD4+ and CD8+T cells are increasing(P = 0. 001) .however,CD95 is expressed more dominantly on CD8+T cells than on CD4+ T cells; expressions of costimulators on T cell subsets are increasing (P < 0.05) ,in which CD4+CD28+T cells and CD8+CD152+T cells are dominant. Conclusion:Imbalanced T lymphocytic subpopulations and the abnormal expressions of CD28/CD152 in patients with ESRF suggest that activated and suppressed regulations of T cells are disturbed,and expressions of CD95 are more dominant on CD8+T cells,which indicates lymphocytes decrease in patients possibly mainly by two pathways--death receptor-ligand pathway and the suppressed signal induced by negative costimulator CD152, so that the striking reduce of CD8+T cells leads to the defect of cellular immune in patients.",
        "keywords": [
            "Fas",
            "CD95",
            "Apoptosis",
            "End-stage renal failure",
            "Cellular immune"
        ],
        "authors": [
            {
                "name": "WANG Lan-Lan",
                "org": ". Division of Clinical Immunology, Department of Laboratory Medicine of West China Hospital, Sichuan University, Chengdu , China"
            },
            {
                "name": "CAI Bei",
                "org": ". Division of Clinical Immunology, Department of Laboratory Medicine of West China Hospital, Sichuan University, Chengdu , China"
            },
            {
                "name": "MI Xu-Hua",
                "org": ". Division of Clinical Immunology, Department of Laboratory Medicine of West China Hospital, Sichuan University, Chengdu , China"
            },
            {
                "name": "FENG Wei-Hua",
                "org": ". Division of Clinical Immunology, Department of Laboratory Medicine of West China Hospital, Sichuan University, Chengdu , China"
            },
            {
                "name": "TANG Jiang-Tao",
                "org": ". Division of Clinical Immunology, Department of Laboratory Medicine of West China Hospital, Sichuan University, Chengdu , China"
            },
            {
                "name": "CHEN Jie",
                "org": ". Division of Clinical Immunology, Department of Laboratory Medicine of West China Hospital, Sichuan University, Chengdu , China"
            }
        ],
        "venue": "Chinese Journal of Immunology",
        "year": 2006
    },
    "NzqNmZ2x": {
        "id": "NzqNmZ2x",
        "title": "Diagnostic value of glucose-6-phosphate isomerase in rheumatoid arthritis patients: systematic review]",
        "abstract": "In order to evaluate the diagnostic accuracy of glucose-6-phosphate isomerase in patients with rheumatoid arthritis, retrieval was performed using the data bases of Medline, Embase, Cochrane library, Cmcc and Cbmdisc (1990 to 2007). We included the articles which reported the studies of GPI measured by enzyme-linked immunosorbent assay in the diagnosis of RA patients. Then we reviewed 15 article and used RevMan Software for analysis; the heterogeneity among the articles was determined to be high (chi2 = 191.65, P < 0.00001). When we analyzed the 5 articles wherein serum was used as the standard, we noticed homogeneity (chi2 = 6.97, P = 0.14). The summary sensitivity was 25%; the summary specificity was 80%; the area under the curve was 0.6279. Our study demonstrated that GPI exhibited high specificity and low sensitivity in diagnosing RA cases. We suggest that GPI be used in conjunction with some assay or other that is characterized by high sensitivity.",
        "keywords": [
            "sensitivity",
            "diagnosis",
            "glucose-6-phosphate isomerase(gpi)",
            "systematic review",
            "heterogeneity",
            "rheumatoid arthritis(ra)",
            "specificity"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Division of Immunology,Department of Laboratory Medicine,West China Hospital of Sichuan University,Chengdu ,China"
            },
            {
                "name": "Lanlan Wang",
                "org": "Division of Immunology,Department of Laboratory Medicine,West China Hospital of Sichuan University,Chengdu ,China"
            },
            {
                "name": "Li Qin",
                "org": "Department of Laboratory Medicine,West China Hospital of Sichuan University,Chengdu ,China"
            },
            {
                "name": "Jing Li",
                "org": "Centre of Evidence-Based Medicine,West China Hospital of Sichuan University,Chengdu ,China"
            },
            {
                "name": "Yongkang Wu",
                "org": "Division of Immunology,Department of Laboratory Medicine,West China Hospital of Sichuan University,Chengdu ,China"
            },
            {
                "name": "Yangjuan Bai",
                "org": "Division of Immunology,Department of Laboratory Medicine,West China Hospital of Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi",
        "year": 2010
    },
    "xmUdIrVN": {
        "id": "xmUdIrVN",
        "title": "Method Comparison for two kinds of luminescence immunoassay by NCCLS-EP9-A2",
        "abstract": "Objective To estimate the bias between the two kinds of luminescence immunoassay, and find out whether each of them can be substitute by the other. Methods IgE was determined in serum by two kinds of luminescence Immunoassay (ACCESS and Elecsys2010). We compared the results of two groups with the procedure as NCCLS-EP9-A2 described. Results The results of the two groups were correlated ( r = 0.994 ). The expected bias was in the range of acceptable bias, the results of the two methods were consistent. Conclusion Both of these two methods are advanced luminescence immunoassay with good repetition. The results of the two groups were correlated. The two methods can be replaceable, and anyone of them can be used to perform a detection with its own reference range.",
        "keywords": [
            "luminescence immunoassay",
            "method comparison"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Laboratory of Clinical Immunology, West China Hospital of Sichuan University,Chengdu"
            },
            {
                "name": "WANG Lan-lan",
                "org": "Laboratory of Clinical Immunology, West China Hospital of Sichuan University,Chengdu"
            },
            {
                "name": "LI Li-xin",
                "org": "Laboratory of Clinical Immunology, West China Hospital of Sichuan University,Chengdu"
            },
            {
                "name": "TANG Jiang-tao",
                "org": "Laboratory of Clinical Immunology, West China Hospital of Sichuan University,Chengdu"
            },
            {
                "name": "LIU Jin",
                "org": "Laboratory of Clinical Immunology, West China Hospital of Sichuan University,Chengdu"
            }
        ],
        "venue": "Chinese Journal of Clinical Laboratory Science",
        "year": 2006
    },
    "VFcKq6MH": {
        "id": "VFcKq6MH",
        "title": "Relationship between abnormality of costimulatory moleculars expression and autoimmune diseases",
        "abstract": "Objective To analyse the difference of costimulatory signal pathways in rheumatoid arthritis(RA) and systemic lupus erythematosus(SLE), and to define the roles of several signal pathways in immune regulation of autoimmune diseases.Methods The expressions of costimulator CD28,CD152(CTLA-4),CD154(CD40L),and inducible costimulator(ICOS) were analyzed by flow cytometry.Results \u2460 CD4~+ T cells percent strikingly increased in RA,and CD8~+T cells were predominant in SLE.\u2461 In SLE,the expressions of CD28 and CD152 on T cell subsets both increased.In RA,the expression of CD28 on T cell subsets decreased,but the CD152 increased.\u2462 CD154 on RA CD4~+T cells was increased but decreased on RA CD8~+T cells.The expression of ICOS on T cell subsets was similar to that of normal control;the expressions of CD154 and ICOS on CD4~+ and CD8~+T cells both decreased in SLE.Conclusion There are different abnormalities of costimulatory pathways in patients with RA or SLE.",
        "keywords": [
            "Rheumatoid arthritis",
            "ICOS",
            "Systemic lupus erythematosus",
            "CD152",
            "CD154",
            "CD28"
        ],
        "authors": [
            {
                "name": "CAI Bei",
                "org": "Department of Laboratory Medicine,West China Hospital of Sichuan University,Chengdu ,China"
            },
            {
                "name": "WANG Lan-lan",
                "org": "Department of Laboratory Medicine,West China Hospital of Sichuan University,Chengdu ,China"
            },
            {
                "name": "FENG Wei-hua",
                "org": "Department of Laboratory Medicine,West China Hospital of Sichuan University,Chengdu ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Department of Laboratory Medicine,West China Hospital of Sichuan University,Chengdu ,China"
            },
            {
                "name": "TANG Jiang-tao",
                "org": "Department of Laboratory Medicine,West China Hospital of Sichuan University,Chengdu ,China"
            },
            {
                "name": "WU Yong-kang",
                "org": "Department of Laboratory Medicine,West China Hospital of Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Immunological Journal",
        "year": 2006
    },
    "RLxeaNid": {
        "id": "RLxeaNid",
        "title": "Relationship between IL-6/IL-6R with Clonal Malignancy",
        "abstract": "Objective:To explore the relationship between IL-6/IL-6R in patients of clonal malignancy of plasma cells and SLE.Methods:Immunoglobulin and light chains were determined by nephelometery.IL-6 and IL-6R were determined in serum by ELISA.Results:As compared with control,level of IL-6 and IL-6R in serum was significantly higher(P<0.05).There was no significant difference between multiple myeloma and macroglobulinemia.It was significantly higher(P<0.05)in clonal malignancy of plasma cells than in SLE.Conclusion:IL-6 stimulates myeloma cells to secrete abnormal immunoglobulin.It plays a role in the pathogenesis of myeloma.In SLE,Th1/Th2 imbalance occur.Th2 cells secrete IL-6,which mediates immune adjustment reaction.Disruption of IL-6 pathway may be used to treat such diseases.",
        "keywords": [
            "clonal malignancy of plasma cells",
            "IL-6"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Department of Laboratory Medicine,West China Hospital,Sichuan University,Chengdu ,China"
            },
            {
                "name": "WANG Lan-lan",
                "org": "Department of Laboratory Medicine,West China Hospital,Sichuan University,Chengdu ,China"
            },
            {
                "name": "LI Li-xin",
                "org": "Department of Laboratory Medicine,West China Hospital,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "West China Medical Journal",
        "year": 2006
    },
    "QQodnrap": {
        "id": "QQodnrap",
        "title": "Research of abnormal costimulatory and apoptotic signal to lymphocytes in patients with rheumatoid arthritis",
        "abstract": "Objective:To explore the functions of diversity of signal molecules expressed on T cells inducing activations of cells and apoptosis in causing imbalanced immunity of patients with RA.Methods:To apply flow cytometer to determine the expression of CD154(CD40L), CD30 and CD95(Fas) on T lymphocytes.Results:Imbalanced T subsets, increasing CD4+T cells and decreasing CD8+T cells were found in peripheral blood of patients with RA. Expressions of CD154 on both CD4+T cells and CD8+T cells increased, but that of CD30, particularly CD4+CD30+T cells decrease.However, expressions of CD95 on T subsets strikingly increased.Conclusion:Abnormal expressions of diverse signal molecules on T lymphocytes lead to the imbalanced immune function in patients with rheumatoid arthritis.",
        "keywords": [
            "CD30",
            "CD154/CD40L",
            "CD95/Fas",
            "Rheumatoid arthritis(RA)"
        ],
        "authors": [
            {
                "name": "WANG Lan-Lan",
                "org": ". Division of Clinical Immunological Laboratory, Department of Laboratory Medicine, Huaxi Hospital, Sichuan University, Chengdu ,China"
            },
            {
                "name": "CAI Bei",
                "org": ". Division of Clinical Immunological Laboratory, Department of Laboratory Medicine, Huaxi Hospital, Sichuan University, Chengdu ,China"
            },
            {
                "name": "CHEN Jie",
                "org": ". Division of Clinical Immunological Laboratory, Department of Laboratory Medicine, Huaxi Hospital, Sichuan University, Chengdu ,China"
            },
            {
                "name": "FENG Wei-Hua",
                "org": ". Division of Clinical Immunological Laboratory, Department of Laboratory Medicine, Huaxi Hospital, Sichuan University, Chengdu ,China"
            }
        ],
        "venue": "Chinese Journal of Immunology",
        "year": 2005
    },
    "ayWlR94o": {
        "id": "ayWlR94o",
        "title": "Method comparison of two systems of flow cytometry",
        "abstract": "Objective To estimate the bias between two systems of flow cytometry. Methods T lymphocytes were determined in 40 blood samples by two systems of flow cytometry(Beckman XL and BD CANTO).The results of two groups were compared with the procedure as NCCLS-EP9-A2 described. Results The results of the two groups were correlated.The expected bias was in the range of acceptable bias.The results of the two methods were consistent. Conclusions Both methods are advanced flow cytometry methods,the results of two groups are correlated.The two methods can be substitutable,and used to perform the same assay.",
        "keywords": [
            "Flow cytometry",
            "Method comparison",
            "T lymphocyte"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Laboratory of Clinical Immunology,Huaxi Hospital of Sichuan University,Sichuan Chengdu ,China"
            },
            {
                "name": "WANG Lanlan",
                "org": "Laboratory of Clinical Immunology,Huaxi Hospital of Sichuan University,Sichuan Chengdu ,China"
            },
            {
                "name": "FENG Weihua",
                "org": "Laboratory of Clinical Immunology,Huaxi Hospital of Sichuan University,Sichuan Chengdu ,China"
            },
            {
                "name": "CAI Bei",
                "org": "Laboratory of Clinical Immunology,Huaxi Hospital of Sichuan University,Sichuan Chengdu ,China"
            }
        ],
        "venue": "Laboratory Medicine",
        "year": 2007
    },
    "vMN3TCvG": {
        "id": "vMN3TCvG",
        "title": "Study on the regulatory effect of FK506 on T cell subgroups and the co-stimulator expression of allo-liver recipients",
        "abstract": "Objective Through observing the influence of FK506 on T cell subgroups and the expression of co-stimulators CD28,CD152 and inducible costimulator(ICOS) in patients receiving allo-liver transplantation and FK506 treatment,to explore the effect of FK506 on T cell signal transduction. Methods The T cell subgroups and the expression of CD28,CD152 and ICOS on peripheral T cells in healthy-control group,disease-control group and treatment group were determined by flowcytometry. Results The total number of T lymphocytes were not significantly different among three groups.Compared with disease-control group,the number of CD4~+ T cell of the treatment group was much lower and the number of CD8~+T cell was much higher;The expressions of CD28 and ICOS significantly decreased while the CD152 expression obviously increased. Conclusions FK506 plays an important role in the quick correction of the turbulence of T cell subgroup balance.Through inhibiting the expression of positive costimulators and promoting the expression of negative costimulator CD152,FK506 blocks the activating signal transduction at the upper stream of T cell immune signal pathway and thus inhibits the activation of T cell.",
        "keywords": [
            "Costimulator",
            "CD152/CTLA-4",
            "FK506",
            "T cell subgroups",
            "CD28"
        ],
        "authors": [
            {
                "name": "BAI Yangjuan",
                "org": ",CAI Pei.Devision of Clinical Immunology,Department of Laboratory Medicine,Huaxi Hospital,Sichuan University,Sichuan Chengdu ,China"
            },
            {
                "name": "WANG Lanlan",
                "org": ",CAI Pei.Devision of Clinical Immunology,Department of Laboratory Medicine,Huaxi Hospital,Sichuan University,Sichuan Chengdu ,China"
            },
            {
                "name": "FENG Weihua",
                "org": ",CAI Pei.Devision of Clinical Immunology,Department of Laboratory Medicine,Huaxi Hospital,Sichuan University,Sichuan Chengdu ,China"
            },
            {
                "name": "CHEN Jie",
                "org": ",CAI Pei.Devision of Clinical Immunology,Department of Laboratory Medicine,Huaxi Hospital,Sichuan University,Sichuan Chengdu ,China"
            }
        ],
        "venue": "Laboratory Medicine",
        "year": 2006
    },
    "AbHOt5ly": {
        "id": "AbHOt5ly",
        "title": "Application value of procalcitonin and immune inflammatory factors for prediction of bacteraemia in patients with hematologic malignancy combined with febrile neutropenia]",
        "abstract": "This study was purposed to evaluate the diagnostic value of procalcitonin (PCT), C-reactive protein, interleukin-6 (IL-6), serum amyloid A (SAA) for bacteremia in patients with hematologic malignancy combined with febrile neutropenia. The total of 297 patients with hematologic malignancy combined with febrile neutropenia were analyzed retrospectively from 1253 patients admitted to West China hospital of Sichuan University from March 2011 to October 2012. They were divided into sepsis group (n = 95) and non-sepsis group (n = 202) according to blood culture. The results showed that the levels of PCT, CRP, IL-6 and SAA in sepsis group were higher than those in non-sepsis group, and there was statistically significant difference between these two groups (P < 0.05). The PCT had an AUC value of 0.974 (P < 0.05), and obviously higher than that of CRP (AUC = 0.681, P < 0.05), IL-6 (AUC = 0.661, P < 0.05) and SAA (AUC = 0.605, P < 0.05). When PCT had cut-off value of 1.06 ng/ml, sensitivity of 95.8%, specificity of 92.1%, and the Youden indicator of 0.879, the negative and positive predictive values were 97.8% and 85.0% respectively, the negative and positive likelihood ratios were 0.05 and 12.5 respectively, and all significantly higher than that of CRP, IL-6 and SAA. It is concluded that for patients with hematologic malignancy combined with febrile neutropenia and bacterial infection, the diagnostic value of serum PCT is superior to that of immune inflammatory factors (CRP, IL-6 and SAA), the PCT can predict the bacterium infection, provide laboratory evidence for rational antimicrobial drug usage and mortality reduction.",
        "keywords": [
            "neutropenia",
            "immune inflammatory factor",
            "blood culture",
            "procalcitonin",
            "bacteremia"
        ],
        "authors": [
            {
                "name": "Yang Fu",
                "org": ""
            },
            {
                "name": "Hong Jiang",
                "org": ""
            },
            {
                "name": "Li-Xin Li",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Jun-Long Zhang",
                "org": ""
            },
            {
                "name": "Lan-Lan Wang",
                "org": ""
            }
        ],
        "venue": "Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology",
        "year": 2013
    },
    "OdqYhjOw": {
        "id": "OdqYhjOw",
        "title": "A Discussion on the Management Idea of CAP Lab Certification in the Teaching of Laboratory Medicine",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "WU Yong-kang",
                "org": "Department of Laboratory Medicine,Huaxi Hospital of Sichuan University,Chengdu ,China"
            },
            {
                "name": "WANG Lan-lan",
                "org": "Department of Laboratory Medicine,Huaxi Hospital of Sichuan University,Chengdu ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Department of Laboratory Medicine,Huaxi Hospital of Sichuan University,Chengdu ,China"
            },
            {
                "name": "BAI Yang-juan",
                "org": "Department of Laboratory Medicine,Huaxi Hospital of Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Journal of Chengdu Medical College",
        "year": 2007
    },
    "qZQvO26S": {
        "id": "qZQvO26S",
        "title": "Exploring on the levels of IL-17,IL-23,TGF-\u03b2,and IL-10 in serum of patients with chronic hepatitis B",
        "abstract": "This study aims to explore the level of cytokines and their function in serum of patients of hepatitis B.The levels of IL-17,IL-23,TGF-\u03b2 and IL-10 were detected by ELISA,while HBV-DNA was detected by RT-PCR.We also tested the liver function of patients.We found that IL-10 was significantly increased in hepatitis B as compared with health control,but IL-7,IL-10 and TGF-\u03b2 demonstrate no significant difference in the two groups;we also found that IL-17 and IL-10 were positively correlated with transaminase level,TGF-\u03b2 was negatively correlated with transaminase level,and IL-10 was positively correlated with HBV-DNA.All this result indicate that IL-17,IL-10 and TGF-\u03b2 are associated with the progress and development of hepatitis B,and IL-10 is associated with the pathogenesis of chronic hepatitis.",
        "keywords": [
            "HBV infection",
            "IL-17",
            "TGF-\u03b2",
            "IL-10",
            "IL-23"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": " Department of Immunology,West China Hospital of Sichuan University,Chengdu ,China"
            },
            {
                "name": "WANG Lanlan",
                "org": " Department of Immunology,West China Hospital of Sichuan University,Chengdu ,China"
            },
            {
                "name": "FU Yang",
                "org": " Department of Immunology,West China Hospital of Sichuan University,Chengdu ,China"
            },
            {
                "name": "LUO Limei",
                "org": " Department of Immunology,West China Hospital of Sichuan University,Chengdu ,China"
            },
            {
                "name": "LIAO Yun",
                "org": " Department of Immunology,West China Hospital of Sichuan University,Chengdu ,China"
            },
            {
                "name": "LI Siyue",
                "org": " Department of Immunology,West China Hospital of Sichuan University,Chengdu ,China"
            },
            {
                "name": "CAI Bei",
                "org": " Department of Immunology,West China Hospital of Sichuan University,Chengdu ,China"
            },
            {
                "name": "LI Yi",
                "org": " Department of Immunology,West China Hospital of Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Immunological Journal",
        "year": 2012
    },
    "YOM1DMv6": {
        "id": "YOM1DMv6",
        "title": "Research on clinical significance of CD\u2083+CD\u2085\u2086+NKT cells and CD\u2083-CD\u2085\u2086+NK cells in patients with malignant tumors]",
        "abstract": "Cytotoxic lymphocytes play an important role in anti-tumor immune. CD\u2083+CD\u2085\u2086+NKT cells, which are a new type of cytotoxic cells, are mainly focused on anti-tumor effect in hematologic malignancy, however its cytotoxic effects on solid tumor are not clear. The aim of this study is to explore the clinical expression and significance of peripheral CD\u2083+CD\u2085\u2086+NKT cells and CD\u2083-CD\u2085\u2086+NK cells in patients with solid malignant tumors.Peripheral T cell subsets and CD\u2083+CD\u2085\u2086+NKT cells and CD\u2083-CD\u2085\u2086+NK cells in 118 patients with malignant tumors (55 lung cancers and 63 breast cancers) and 46 healthy volunteers were analysed by flow cytometer.Compared with healthy control, both peripheral CD\u2083+T lymphocytes and CD\u2083+CD\u2084+ T lymphocytes in patients with lung cancer or breast cancer significantly decreased, but CD\u2083+CD\u2088+T lymphocytes only increased significantly in patients with lung cancer (P < 0.01). Further analysis of CD\u2083+CD\u2085\u2086+NKT cells and CD\u2083-CD\u2085\u2086+NK cells indicated that there was difference between lung cancer group and breast cancer group. In patients with lung cancer CD\u2083+CD\u2088+T cells and CD\u2083+CD\u2085\u2086+NKT cells increased significantly, and in patients with breast cancer CD\u2083+CD\u2085\u2086+NKT cells and CD\u2083-CD\u2085\u2086+NK cells increased obviously.In patients with lung cancer or breast cancer, CD\u2083+CD\u2085\u2086+NKT cells play the important role in anti-tumor effects, however, the anti-tumor effects of CD\u2083+CD\u2088+CTL and CD\u2083-CD\u2085\u2086+ NK cells were different.",
        "keywords": [
            "cd3+cd8+t lymphocytes cd3+cd56+nkt lymphocytes cd3-cd56+ nk lymphocytes malignant tumor"
        ],
        "authors": [
            {
                "name": "Weihua Feng",
                "org": ". Department of Laboratory Medicine, West China Hospital of Sichuan university, Chengdu, Sichuan , P.R.China"
            },
            {
                "name": "Bei Cai",
                "org": ". Department of Laboratory Medicine, West China Hospital of Sichuan university, Chengdu, Sichuan , P.R.China"
            },
            {
                "name": "Lanlan Wang",
                "org": ". Department of Laboratory Medicine, West China Hospital of Sichuan university, Chengdu, Sichuan , P.R.China"
            },
            {
                "name": "Jie Chen",
                "org": ". Department of Laboratory Medicine, West China Hospital of Sichuan university, Chengdu, Sichuan , P.R.China"
            }
        ],
        "venue": "Zhongguo fei ai za zhi = Chinese journal of lung cancer",
        "year": 2007
    },
    "0jUfOyl9": {
        "id": "0jUfOyl9",
        "title": "Immunity regulation and acute reaction protein reactants in esophagus cancer patients before and after operation",
        "abstract": "Objective To explore the changes and functions of lymphocytes and their cytokines, as well as some acute reaction proteins (ARPs) in patients with esophagus cancer before and after operation. Methods Total of 28 patients with esophagus cancer and 46 healthy controls were analyzed for T cells, NK cells, IL-6, TNF-\u03b1, and ARPs (CRP, PAB, TRF). Results As compared with control, CD3~+CD4~+T cells were increased (P<0.05) but CD3~+CD8~+T cells were decreased (P < 0.05), thus the ratio was increased (P < 0.05) in patients with esophagus cancer, and the trend was more significant after operation (P < 0.05). NK cells in patients with esophagus cancer were decreased after operation (P < 0.05). The levels of IL-6 and TNF-\u03b1 in serum of the patients were increased (P < 0.05) and the level of CRP was increased (P < 0.05), but the levels of PAB and TRF were decreased (P < 0.05), and the trend was more significant after operation (P < 0.05). Conclusion In esophagus cancer patients, the disturbance of T lymphocytes leads to the disturbance of cytokines. More and more IL-6 and TNF-\u03b1 induce liver cells to synthesize ARPs. Positive ARPs such as CRP is increased, while negative ARPs such as PAB and TRF are decreased. This study helps us to learn about immune pathology of esophagus cancer, interpret the mechanisms, and design treat plan.",
        "keywords": [
            "Cellular immunity",
            "Esophagus cancer",
            "Acute reaction protein",
            "Cytokines"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Laboratory of Clinical Immunology, Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu , China"
            },
            {
                "name": "WANG Lan-lan",
                "org": "Laboratory of Clinical Immunology, Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu , China"
            },
            {
                "name": "TANG Jiang-tao",
                "org": "Laboratory of Clinical Immunology, Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu , China"
            },
            {
                "name": "FENG Wei-hua",
                "org": "Laboratory of Clinical Immunology, Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu , China"
            },
            {
                "name": "LI Li-xin",
                "org": "Laboratory of Clinical Immunology, Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu , China"
            }
        ],
        "venue": "Immunological Journal",
        "year": 2006
    },
    "qHZWvG8g": {
        "id": "qHZWvG8g",
        "title": "Research on the relationship between abnormal regulation of T lymphocytes and disturbance of immune function in systemic lupus erythematosus and rheumatoid arthritis",
        "abstract": "Objective To analyse the expression of peripheral blood T lymphocyte subsets and costimulators on them in patients with systemic lupus erythematosus(SLE) and rheumatoid arthritis(RA) and discuss the disturbance of T lymphocytes in human SLE and RA. Methods Apply flow cytometry to determine the expressions of costimulators CD28,CD152,ICOS,CD154,CD30 and CD95 on T lymphocyte subsets in patients with SLE and RA. Results Compared with healthy control,percentage of CD8~+T cell and CD4~+T cell increased significantly in SLE and in RA respectively(P<0.05).Expressions of CD28 and CD152 on CD4~+T cells and CD8~+T cells in SLE increased strikingly,that of ICOS on them decreased strikingly(P<0.05) as well as the dropping of CD154 and CD30;In RA expressions of CD28 on T lymphocyte subsets decreased significantly,that of CD152 increased(P<0.05),that of ICSO on T cell subsets in SLE was similar to that in healthy control(P>0.05);That of CD154 and CD30 on CD4~+T cells or CD8~+T cells increased or decreased respectively.Expression of CD95 on CD4~+T cells and CD8~+T cells in SLE and RA were more than that in healthy control. Conclusions Patients with SLE and RA have different characteristics of peripheral blood T lymphocyte subsets disturbances and the abnormal activation of T cells is regulated by the complex costimulatory net.",
        "keywords": [
            "Rheumatoid arthritis",
            "Systemic lupus erythematosus",
            "T lymphocyte",
            "Costimulators"
        ],
        "authors": [
            {
                "name": "WANG Lanlan",
                "org": ".Division of Clinical Immunology,Department of Laboratory Medicine,Huaxi Hospital of Sichuan University,Sichuan Chengdu ,China"
            },
            {
                "name": "CAI Bei",
                "org": ".Division of Clinical Immunology,Department of Laboratory Medicine,Huaxi Hospital of Sichuan University,Sichuan Chengdu ,China"
            },
            {
                "name": "FENG Weihua",
                "org": ".Division of Clinical Immunology,Department of Laboratory Medicine,Huaxi Hospital of Sichuan University,Sichuan Chengdu ,China"
            },
            {
                "name": "CHEN Jie",
                "org": ".Division of Clinical Immunology,Department of Laboratory Medicine,Huaxi Hospital of Sichuan University,Sichuan Chengdu ,China"
            }
        ],
        "venue": "Laboratory Medicine",
        "year": 2006
    },
    "FrrIa7X8": {
        "id": "FrrIa7X8",
        "title": "The use of PCT, CRP, IL-6 and SAA in critically ill patients for an early distinction between candidemia and Gram positive/negative bacteremia.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Yang Fu",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Bei Cai",
                "org": ""
            },
            {
                "name": "Junlong Zhang",
                "org": ""
            },
            {
                "name": "Lixin Li",
                "org": ""
            },
            {
                "name": "Chang Liu",
                "org": ""
            },
            {
                "name": "Yan Kang",
                "org": ""
            },
            {
                "name": "Lanlan Wang",
                "org": ""
            }
        ],
        "venue": "The Journal of infection",
        "year": 2012
    },
    "1YmLXMFG": {
        "id": "1YmLXMFG",
        "title": "Diagnostic values of procalcitonin, interleukin-6, c reactive protein and serum amyloid a in Sepsis",
        "abstract": "Objective To evaluate the diagnostic values of procalcitonin (PCT), C reactive protein (CRP), interleukin-6 (IL-6), serum amyloid A (SAA) in septic patients. Methods This study totally enrolled 390 patients who were admitted to West China Hospital, Sichuan University from March to November 2011 with septic manifestation. The patients were divided into sepsis group (n = 203) and non-sepsis group (n = 187) according to clinical infectious disease standard. PCT and IL-6 were measured by automatic electrochemiluminescence (ECL) analyser. CRP was measured by rate immunonephelometric analyser, SAA was measured by fixed time nephelometric method. The diagnostic powers of these four biomakers were constructed by receiver operating characteristics (ROC) curves. Results There were statistically significant differences on the values of PCT, CRP, IL-6, SAA between sepsis group and non-sepsis group. PCT had an AUC value of 0.919 (P<0.05) which was higher than that of CRP, IL-6, and SAA (P< 0.05). CRP performed with an AUC of 0.755 (P<0.05), IL-6 with an AUC of 0.786 (P<0.05), and SAA with the lowest AUC of 0.645 (P<0.05). The combination AUC was 0.892(P<0.05) and there was no statistically significant difference when compared to PCT. As an early diagnostic indicator of sepsis, the cut-off value of PCT was 1.18 ng/mL, with sensitivity of 84.7%, specific of 83.4%, while Youden index was 0.681, positive predict value was 64.1%, negative predict value was 75.8%, positive likelihood ratio was 5.10, negative likelihood ratio was 0.18, respectively. A statistically significant difference was available on the value of PCT in septic patients between ICU and non-ICU. Conclusion PCT as an early independent biomarker for sepsis is superior to immune inflammatory biomarkers (CRP, IL-6, SAA), also is better than the combination of these four biomarkers for economic effect.",
        "keywords": [
            "Blood culture",
            "Immune inflammatory biomarkers",
            "Procalcitonin",
            "Sepsis"
        ],
        "authors": [
            {
                "name": "Yang Fu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jie Chen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Bei Cai",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jun-Long Zhang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Li-Xin Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lan-Lan Wang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2012
    },
    "VYMi0m6i": {
        "id": "VYMi0m6i",
        "title": "Role of Fas-FasL and caspase-3 signal transduction pathway in promoting apoptosis of T lymphocyte subset in SLE patients]",
        "abstract": "To explore the relationship between Fas-FasL-mediated signal transduction pathway and apoptosis disorder of T lymphocyte subset in SLE patients.The expression rate of membrane Fas, FasL and that of intracellular activated caspase-3 of T lymphocyte subset were determined by flow cytometry.Compared with healthy control group, the expression rate of membrane Fas on CD4(+) T cells significantly increased in SLE patients in the active and inactive phases (P<0.05), however, that on CD8(+) T cells slightly increased but there was no statistical significance (P>0.05). The expression rate of FasL on T cell subset in SLE patients in the active and inactive phases significantly increased (P<0.05) but there was no obvious difference of the expression rate of Fas and FasL on T cell subset between the two disease groups (P>0.05). The expression rate of intracellular activated caspase-3 in T cell subset of SLE patients in the active phase was notably higher than that in the inactive phase and healthy control group (P<0.05). The expression rate of intracellular activated caspase-3 in T cell subset of SLE patients in the inactive phase was slightly higher than that in health control group but there was no statistical significance.Apoptotic speed of T lymphocyte subset in SLE patients was accelerated while CD4(+) T cells were in a state of active apoptosis. It is possible that Fas-FasL signal transduction pathway plays an important role in the induction of T cell apoptosis. The degree of apoptosis of T lymphocytes closely correlates with the disease's activity in SLE patients.",
        "keywords": [
            "systemic lupus erythematosus(sle)",
            "activated caspase-3",
            "fasl",
            "fas",
            "t lymphocyte"
        ],
        "authors": [
            {
                "name": "Xue Chen",
                "org": " Clinical Immunological Laboratory, Department of Laboratory Medic-ine, Huaxi Hospital, Sichuan University, Chengdu , China"
            },
            {
                "name": "Lan-lan Wang",
                "org": " Clinical Immunological Laboratory, Department of Laboratory Medic-ine, Huaxi Hospital, Sichuan University, Chengdu , China"
            },
            {
                "name": "Bei Cai",
                "org": " Clinical Immunological Laboratory, Department of Laboratory Medic-ine, Huaxi Hospital, Sichuan University, Chengdu , China"
            },
            {
                "name": "Jie Chen",
                "org": " Clinical Immunological Laboratory, Department of Laboratory Medic-ine, Huaxi Hospital, Sichuan University, Chengdu , China"
            },
            {
                "name": "Wei-hua Feng",
                "org": " Clinical Immunological Laboratory, Department of Laboratory Medic-ine, Huaxi Hospital, Sichuan University, Chengdu , China"
            }
        ],
        "venue": "Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology",
        "year": 2006
    },
    "7mYp8gAf": {
        "id": "7mYp8gAf",
        "title": "Design and implementation of web-based tobacco planting expert system",
        "abstract": "According to the basic principle of expert system, an Internet-based expert system of tobacco planting is designed, in which tobacco planting theory, applied technique and computer network technology are integrated. This paper introduces in detail the software and hardware condition, the implementing method for this expert system, such as the whole structure of expert system, the classification of knowledge point, the building of the knowledge base and the rule base, the manifestation of the reasoning machine, and so on.",
        "keywords": [
            "Expert system",
            "Tobacco planting",
            "Web"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Huazhong Agricultural University(Huazhong Agricultural University),Wuhan,China"
            },
            {
                "name": "Liyuan He",
                "org": "Huazhong Agricultural University(Huazhong Agricultural University),Wuhan,China"
            },
            {
                "name": "Shengxiang Xu",
                "org": "Huazhong Agricultural University(Huazhong Agricultural University),Wuhan,China"
            },
            {
                "name": "Wei Huang",
                "org": "Huazhong Agricultural University(Huazhong Agricultural University),Wuhan,China"
            },
            {
                "name": "Wenjie Ma",
                "org": "Huazhong Agricultural University(Huazhong Agricultural University),Wuhan,China"
            }
        ],
        "venue": "Jisuanji Gongcheng/Computer Engineering",
        "year": 2006
    },
    "tINqJ0nq": {
        "id": "tINqJ0nq",
        "title": "Dual model for the optimization of formulation and cost of compound fertilizer raw materials",
        "abstract": "An optimization dual model was developed to minimize the cost of Compound Fertilizer. The model was used to illustrate the bidirectional effects of both raw material and constraints, especially when the price of raw material was changing rapidly. The most economic formulations were calculated by Lindo 6.0. The reason for raw material unadopted was that their effective components were not matched to price by Reduced cost analysis. The influence of adoptive raw materials was discussed through Sensitivity analysis, and the phosphorus was the most sensitive factor in actual formulations. The sequence of three main elements' shadow price was K > P > N, which indicated the Potassium influenced the total cost mostly.",
        "keywords": [
            "Dual model",
            "Reduced cost",
            "Sensitivity analysis",
            "Shadow price"
        ],
        "authors": [
            {
                "name": "Wei Huang",
                "org": "Huazhong Agricultural University(Huazhong Agricultural University),Wuhan,China"
            },
            {
                "name": "Liyuan He",
                "org": "Huazhong Agricultural University(Huazhong Agricultural University),Wuhan,China"
            },
            {
                "name": "Wenjie Ma",
                "org": "Huazhong Agricultural University(Huazhong Agricultural University),Wuhan,China"
            },
            {
                "name": "Shengxiang Xu",
                "org": "Huazhong Agricultural University(Huazhong Agricultural University),Wuhan,China"
            },
            {
                "name": "Jie Chen",
                "org": "Huazhong Agricultural University(Huazhong Agricultural University),Wuhan,China"
            }
        ],
        "venue": "Nongye Gongcheng Xuebao/Transactions of the Chinese Society of Agricultural Engineering",
        "year": 2006
    },
    "JKI4BjTW": {
        "id": "JKI4BjTW",
        "title": "On Grain Safety and Quality Evaluation of Cultivated Land in Jiangling County of Hubei Province Based on GIS",
        "abstract": "As one of the main commodity grain bases of Jianghan Plain,Jiangling County has played a significant role in grain security of Hubei and stability of national economy.It is a direct impact to security base of grain product that the cultivated land quantity reduce and quality drop.Combined the task of quality evaluation of cultivated land in Jiangling County,the quantity,quality and distribution of cultivated land are showed,the relationship between cultivated land and grain security is analyzed scientifically also.With GIS software package,the map of results is drawn.The productivity of cultivated land in Jiangling County is in 1,2,3 and 4 grades,and the percent in areas is 23.46%,52.10%,21.14% and 3.30%,respectively.Most of them are in better than average,showed that the overall level of cultivated land quality in this area is higher.So it is a credible guarantee to Jiangling County's grain security.",
        "keywords": [
            "grain safety",
            "Jiangling County",
            "quality evaluation of cultivated land",
            "GIS"
        ],
        "authors": [
            {
                "name": "XU Sheng-xiang",
                "org": "College of Resource and Environment,Huazhong Agricultural University,Wuhan ,China"
            },
            {
                "name": "HE Li-yuan",
                "org": "College of Resource and Environment,Huazhong Agricultural University,Wuhan ,China"
            },
            {
                "name": "LU Ming-xing",
                "org": "Workstation of Soil and Fertilizer,Agricultural Department of Hubei Province,Wuhan ,China"
            },
            {
                "name": "HUANG Wei",
                "org": "College of Resource and Environment,Huazhong Agricultural University,Wuhan ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Resource and Environment,Huazhong Agricultural University,Wuhan ,China"
            }
        ],
        "venue": "Research of Agricultural Modernization",
        "year": 2006
    },
    "7Z7E4Zlh": {
        "id": "7Z7E4Zlh",
        "title": "Application of Artificial Neural Network in Production Expert System of Orange",
        "abstract": "With the orange industrialization demand of the reservoir region of Three Gorges,a comparatively intact range of knowledge of network production expert system of orange is designed and developed by the method of expert system combined with the technology of artificial neural network.It can meet the information demand of growers as well as administrator,popularize the production technology and instruct directly the production management of orange.The principle of neural network is adopted,knowledge is organized rationally and human's thinking mode is simulated,so its reasoning mechanism has a big advantage over the producing type of reasoning.Regarding the nutrition diagnosis as an instance,the whole framework and me\uffe3thod of realization are presented in detail in the expert system based on artificial neural network.",
        "keywords": [
            "Artificial Neural Network",
            "Nutrition Diagnosis",
            "Orange Producing",
            "Expert System"
        ],
        "authors": [
            {
                "name": "XU Sheng-xiang",
                "org": "College of Resource & Environment,Huazhong Agricultural University,Wuhan Hubei ,China"
            },
            {
                "name": "HE Li-yuan",
                "org": "College of Resource & Environment,Huazhong Agricultural University,Wuhan Hubei ,China"
            },
            {
                "name": "HUANG Wei",
                "org": "College of Resource & Environment,Huazhong Agricultural University,Wuhan Hubei ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Resource & Environment,Huazhong Agricultural University,Wuhan Hubei ,China"
            }
        ],
        "venue": "Application Research of Computers",
        "year": 2006
    },
    "YNhqIhw6": {
        "id": "YNhqIhw6",
        "title": "Designing and Materialization of MapXtreme-Based Soil Resource Information System of the Three-Gorge Reservoir Region, Hubei",
        "abstract": "Soil information data have been playing an important role in agricultural production. An soil resource information system of the Three-Gorges Reservoir Region of HuBei is designed with MapXtreme as the platform of the network geographical information system (WebGIS), and the aid of database, network and geographical information system (GIS) technology. The designing of the system is of great significance to extension of the range of sharing of soil information of the reservoir region and efficient management of the soil resources. This paper introduces breifly design philosophy and structure of the system and key methods of materializing the system , and cites some examples of operation of the system.",
        "keywords": [
            "MapXtreme",
            "WebGIS",
            "Soil resource information",
            "The Three-Gorge Reservoir Region"
        ],
        "authors": [
            {
                "name": "XU Sheng-xiang",
                "org": " College of Resource and Environment, Huazhong Agricultural University, Wuhan , China "
            },
            {
                "name": "HE Li-yuan",
                "org": " College of Resource and Environment, Huazhong Agricultural University, Wuhan , China "
            },
            {
                "name": "HUANG Wei",
                "org": " College of Resource and Environment, Huazhong Agricultural University, Wuhan , China "
            },
            {
                "name": "CHEN Jie",
                "org": " College of Resource and Environment, Huazhong Agricultural University, Wuhan , China "
            }
        ],
        "venue": "Soils",
        "year": 2006
    },
    "Kwfukcwf": {
        "id": "Kwfukcwf",
        "title": "The Design of Web-Based Orange Planting Expert System",
        "abstract": "It is significant to build an expert system based on Internet to extend the sharing range of knowledge.According to the basic principle of expert system,a Web-based expert system of orange planting has been designed,combined with the orange industrialization demand of the reservoir region of Three Gorges.The whole framework,the database,the rule base and the building of reasoning machine have been introduced in the expert system.Regarded the diagnosis of diseases and insect pests as an instance,a method of using computer technology to integrate the orange planting science with expertise is also discussed in this paper.",
        "keywords": [
            "expert system",
            "orange",
            "Web",
            "diagnosis of plant diseases and insect pests"
        ],
        "authors": [
            {
                "name": "Xu Shengxiang",
                "org": "College of Resource and Environment,Huazhong Agricultural University,Wuhan "
            },
            {
                "name": "He Liyuan",
                "org": "College of Resource and Environment,Huazhong Agricultural University,Wuhan "
            },
            {
                "name": "Huang Wei",
                "org": "College of Resource and Environment,Huazhong Agricultural University,Wuhan "
            },
            {
                "name": "Chen Jie",
                "org": "College of Resource and Environment,Huazhong Agricultural University,Wuhan "
            }
        ],
        "venue": "Computer Engineering and Applications",
        "year": 2006
    },
    "B51HnPEN": {
        "id": "B51HnPEN",
        "title": "Image segmentation based on transmission characteristics of flue-cured tobacco leaves",
        "abstract": "Reflection and transmission images of flue-cured tobacco leaf were both taken in specially-designed lamp box, and then imported into computer for digital analysis. The comparison between the tobacco leaf area and background area for RGB attributes in these two types of images were conducted by sampling with a moving 3 \u00d7 3 matrix of pixels. It was found that most of the blue vector value of pixels in transmission image of tobacco leaf were equal to zero and few of them with greater than zero were distributed discontinuously within the matrix. It was also found that the relative standard deviation (RSD) of blue vector value in a matrix with nine pixels located on the tobacco leaf area in the transmission image was either 0 or more than 100%. Based on the findings, an approach to image segmentation with area-oriented statistics was thus proposed in this paper. The results show that the segmentation accuracy is higher than that by the method of point-oriented statistics, and the average pixels of all segmented image in this study were 0.65% more than those by point statistics per tobacco leaf. The characteristics of the original object image were well kept after segmentation. The presented method may be helpful to increase segmentation accuracy and lay foundations for further studies by using transmission characteristics of tobacco leaf.",
        "keywords": [
            "Area-oriented statistics segmenting method",
            "Flue-cured tobacco leaf",
            "Image segmentation",
            "Transmission characteristics",
            "Transmission image"
        ],
        "authors": [
            {
                "name": "Wenjie Ma",
                "org": "Huazhong Agricultural University(Huazhong Agricultural University),Wuhan,China"
            },
            {
                "name": "Liyuan He",
                "org": "Huazhong Agricultural University(Huazhong Agricultural University),Wuhan,China"
            },
            {
                "name": "Shengxiang Xu",
                "org": "Huazhong Agricultural University(Huazhong Agricultural University),Wuhan,China"
            },
            {
                "name": "Jie Chen",
                "org": "Huazhong Agricultural University(Huazhong Agricultural University),Wuhan,China"
            },
            {
                "name": "Zhaohui Wu",
                "org": "Huazhong Agricultural University(Huazhong Agricultural University),Wuhan,China"
            }
        ],
        "venue": "Nongye Gongcheng Xuebao/Transactions of the Chinese Society of Agricultural Engineering",
        "year": 2006
    },
    "2JQPaiJA": {
        "id": "2JQPaiJA",
        "title": "EFFECTS OF JITAI ON OPIOID-INDUCED DRUG-SEEKING BEHAVIOR AND RELAPSE",
        "abstract": "Objective: To study the effects of Jitai,a traditional Chinese medicine,on opioid-induced drug-seeking behavior and relapse.Methods:Models of heroin self-administration in rats and morphine conditioned place preference(CPP) in mice were established and saline or Jitai was administrated through intragastric way to investigate the effects of Jitai on self-administration behavior and reinstatement of CPP.Results:Jitai at the dose of 3.6 g\u00b7kg-1 could inhibit heroin self-administration in rats.Jitai at the dose of 4.3 g\u00b7kg-1could inhibit reinstatement of CPP following a priming injection of morphine in mice.Conclusion:Jitai has the ability to inhibit opioid-induced drug-seeking in animal,and might have a preventive effect on relapse.",
        "keywords": [
            "drug-seeking behavior",
            "Jitai",
            "relapse",
            "self-administration",
            "conditioned place preference"
        ],
        "authors": [
            {
                "name": "CHEN Zhongguo",
                "org": "School of Basic Medical Sciences,Nanjing Medical University,Nanjing,,China"
            },
            {
                "name": "CHAI Jingrui",
                "org": "State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,,China"
            },
            {
                "name": "JIANG Lihe",
                "org": "State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,,China"
            },
            {
                "name": "CHEN Jie",
                "org": "State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,,China"
            },
            {
                "name": "HU Gang",
                "org": "School of Basic Medical Sciences,Nanjing Medical University,Nanjing,,China"
            },
            {
                "name": "LIU Jinggen",
                "org": "State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,,China"
            }
        ],
        "venue": "Chinese Journal of Drug Dependence",
        "year": 2011
    },
    "6GzKm4zx": {
        "id": "6GzKm4zx",
        "title": "Design, synthesis and antalgic activities of aralkyl-ketone-4-piperidol derivatives]",
        "abstract": "A series of aralkyl-ketone-4-piperidol derivatives were synthesized and tested for their analgesic activities. All of the novel 30 compounds were prepared from 4-piperidone and alpha-halo-aralkyl-ketone through five steps, including Boc protection, nucleophilic addition in presence of CeCl3/NaI catalyst, deprotection, condensation and salification. Their structures were confirmed by 1H NMR and HRMS. Preliminary in vivo pharmacological trials showed that most of the synthesized compounds revealed analgesic effects. Among the tested compounds, 8, 13 and 22 exhibited potent analgesic activities in both mice writhing and mice hot plate model. The three compounds have low affinity for mu, delta, kappa receptors, which is a chance to find a better precursor of non-opioid analgesic for further optimization.",
        "keywords": [
            "non-opioid analgesic",
            "aralkyl-ketone-4-piperidol derivatives",
            "synthesis"
        ],
        "authors": [
            {
                "name": "Guan Wang",
                "org": " Shanghai Institute of Pharmaceutical Industry, Shanghai , China"
            },
            {
                "name": "Gui-sen Zhang",
                "org": " Jiangsu NHWA Pharmaceutical CO., LTD., Xuzhou , China"
            },
            {
                "name": "Lin Guo",
                "org": " Jiangsu NHWA Pharmaceutical CO., LTD., Xuzhou , China"
            },
            {
                "name": "Jie Chen",
                "org": " Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai , China"
            },
            {
                "name": "Jian-qi Li",
                "org": " Shanghai Institute of Pharmaceutical Industry, Shanghai , China"
            }
        ],
        "venue": "Yao xue xue bao = Acta pharmaceutica Sinica",
        "year": 2009
    },
    "zJrfqpIB": {
        "id": "zJrfqpIB",
        "title": "EFFECTS OF JITAI TABLETS ON IMMUNE FUNCTIONIN MORPHINE DEPENDENT MICE",
        "abstract": "Objective:To observe the effects of Jitai tablets on immune function in morphine dependent mice.Methods:A chronic morphine dependent model was established by repeated subcutaneous injection of morphine in mice.Thymus and spleen index were determined.Carbon clearance test,dinitrofluorobenzene-induced delayed type hypersensitivity test(DTH) and hemolysin test were employed to evaluate the immunomodulating effects of Jitai tablets in morphine dependent mice.Results:Jitai tablets(0.30 g\u00b7kg-1 and 0.60 g\u00b7kg-1) significantly increased clearance index(K),phagocytic index(\u03b1),ear swelling,hemolysin level(HC50 value) as well as thymus and spleen index in morphine dependent mice(P<0.01).Conclusion:Jitai tablets can significantly enhance the immune function of morphine dependent mice.",
        "keywords": [
            "immune function",
            "Jitai tablet",
            "morphine dependence"
        ],
        "authors": [
            {
                "name": "WANG Yuhua",
                "org": "School of Pharmacy,China Pharmaceutical University,Nanjing,,China;School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing,,China;State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,,China"
            },
            {
                "name": "TAO Yimin",
                "org": "State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,,China"
            },
            {
                "name": "CHEN Jie",
                "org": "State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,,China"
            },
            {
                "name": "XU Xuejun",
                "org": "State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,,China"
            },
            {
                "name": "CHI Zhiqiang",
                "org": "State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,,China"
            },
            {
                "name": "LIU Jinggen",
                "org": "State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,,China"
            }
        ],
        "venue": "Chinese Journal of Drug Dependence",
        "year": 2011
    },
    "vaIOydgQ": {
        "id": "vaIOydgQ",
        "title": "Highly selective and potent mu opioid ligands by unexpected substituent on morphine skeleton.",
        "abstract": "Unexpected substituent on the well-known morphine skeleton is described to be account for highly selective and potent mu opioid ligands, which is strongly connected to substituted aromatic groups on this omitted 8alpha-position.",
        "keywords": [],
        "authors": [
            {
                "name": "Wei Li",
                "org": "Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China."
            },
            {
                "name": "Yi-Min Tao",
                "org": ""
            },
            {
                "name": "Yun Tang",
                "org": ""
            },
            {
                "name": "Xue-Jun Xu",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Wei Fu",
                "org": ""
            },
            {
                "name": "Xing-Hai Wang",
                "org": ""
            },
            {
                "name": "Bo Chao",
                "org": ""
            },
            {
                "name": "Wei Sheng",
                "org": ""
            },
            {
                "name": "Qiong Xie",
                "org": ""
            },
            {
                "name": "Zhui-Bai Qiu",
                "org": ""
            },
            {
                "name": "Jing-Gen Liu",
                "org": ""
            }
        ],
        "venue": "Bioorganic & medicinal chemistry letters",
        "year": 2010
    },
    "OF9IS0ea": {
        "id": "OF9IS0ea",
        "title": "THE EFFECTS OF JITAI TABLET ON THE PAIN AND WITHDRAWAL SYMPTOMSPRECIPITATED BY NALOXONE IN MORPHINE DEPENDENT MICE",
        "abstract": "Objective:To observe the analgesic effect of JITAI Tablet on induced pain in mice and the withdrawal symptoms of morphine-induced physical dependence.Methods:The analgesic effects of JITAI Tablet at different concentrations were measured by writhing induced by acetic acid(2.4 g\u00b7kg-1,3.6 g\u00b7kg-1,4.8 g\u00b7kg-1) and hot-plate tests(6.0 g\u00b7kg-1,9.0 g\u00b7kg-1,12.0 g\u00b7kg-1).Withdrawal syndromes precipitated by naloxone after given increasing doses of morphine and the effect of JITAI Tablet at differential concentrations(1.2 g\u00b7kg-1,2.4 g\u00b7kg-1,3.6 g\u00b7kg-1) on naloxone-precipitated jumping was examined.Results:JITAI Tablet significantly reduced the writhing frequency induced by acetic acid and the maximal inhibition value is 71.7%.It was found that JITAI Tablet also obviously enhanced the pain threshold in hot-plate test with the ED50 value of 8.34 g\u00b7kg-1.Importantly,JITAI Tablet obviously decreased the number of jumping caused by injection of naloxone(P<0.01).Conclusion:JITAI Tablet had obvious analgesia effects and could inhibit withdrawal symptoms precipitated by naloxone.",
        "keywords": [
            "withdrawal syndromes",
            "hot-plate test",
            "dose increasing method",
            "analgesia",
            "writhing test",
            "JITAI Tablet"
        ],
        "authors": [
            {
                "name": "WANG Jun",
                "org": "School of Life Science and Technology,China Pharmaceutical University,Nanjing,,China;State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,,China"
            },
            {
                "name": "JIANG Lihe",
                "org": "State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,,China"
            },
            {
                "name": "WANG Yuhua",
                "org": "School of Life Science and Technology,China Pharmaceutical University,Nanjing,,China;School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing,,China"
            },
            {
                "name": "TAO Yimin",
                "org": "State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,,China"
            },
            {
                "name": "CHEN Jie",
                "org": "State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,,China"
            },
            {
                "name": "XU Xuejun",
                "org": "State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,,China"
            },
            {
                "name": "XI Tao",
                "org": "School of Life Science and Technology,China Pharmaceutical University,Nanjing,,China"
            },
            {
                "name": "LIU Jinggen",
                "org": "State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,,China"
            }
        ],
        "venue": "Chinese Journal of Drug Dependence",
        "year": 2012
    },
    "dJWoUQke": {
        "id": "dJWoUQke",
        "title": "Serine 363 of the {delta}-opioid receptor is crucial for adopting distinct pathways to activate ERK1/2 in response to stimulation with different ligands.",
        "abstract": "Distinct opioid receptor agonists have been proved to induce differential patterns of ERK activation, but the underlying mechanisms remain unclear. Here, we report that Ser363 in the \u03b4-opioid receptor (\u03b4OR) determines the different abilities of the \u03b4OR agonists DPDPE and TIPP to activate ERK by G-protein- or \u03b2-arrestin-dependent pathways. Although both DPDPE and TIPP activated ERK1/2, they showed different temporal, spatial and desensitization patterns of ERK activation. We show that that DPDPE employed G protein as the primary mediator to activate the ERK cascade in an Src-dependent manner, whereas TIPP mainly adopted a \u03b2-arrestin1/2-mediated pathway. Moreover, we found that DPDPE gained the capacity to adopt the \u03b2-arrestin1/2-mediated pathway upon Ser363 mutation, accompanied by the same pattern of ERK activation as that induced by TIPP. Additionally, we found that TIPP- but not DPDPE-activated ERK could phosphorylate G-protein-coupled receptor kinase-2 and \u03b2-arrestin1. However, such functional differences of ERK disappeared with the mutation of Ser363. Therefore, the present study reveals a crucial role for Ser363 in agonist-specific regulation of ERK activation patterns and functions.",
        "keywords": [],
        "authors": [
            {
                "name": "Chi Xu",
                "org": "State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China."
            },
            {
                "name": "Min-Hua Hong",
                "org": ""
            },
            {
                "name": "Le-Sha Zhang",
                "org": ""
            },
            {
                "name": "Yuan-Yuan Hou",
                "org": ""
            },
            {
                "name": "Yu-Hua Wang",
                "org": ""
            },
            {
                "name": "Fei-Fei Wang",
                "org": ""
            },
            {
                "name": "Yue-Jun Chen",
                "org": ""
            },
            {
                "name": "Xue-Jun Xu",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Xin Xie",
                "org": ""
            },
            {
                "name": "Lan Ma",
                "org": ""
            },
            {
                "name": "Zhi-Qiang Chi",
                "org": ""
            },
            {
                "name": "Jing-Gen Liu",
                "org": ""
            }
        ],
        "venue": "Journal of cell science",
        "year": 2010
    },
    "62A5O3I4": {
        "id": "62A5O3I4",
        "title": "Pharmacological characterization of ATPM [(-)-3-aminothiazolo[5,4-b]-N-cyclopropylmethylmorphinan hydrochloride], a novel mixed kappa-agonist and mu-agonist/-antagonist that attenuates morphine antinociceptive tolerance and heroin self-administration behavior.",
        "abstract": "ATPM [(-)-3-amino-thiazolo[5,4-b]-N-cyclopropylmethylmorphinan hydrochloride] was found to have mixed kappa- and mu-opioid activity and identified to act as a full kappa-agonist and a partial mu-agonist by in vitro binding assays. The present study was undertaken to characterize its in vivo effects on morphine antinociceptive tolerance in mice and heroin self-administration in rats. ATPM was demonstrated to yield more potent antinociceptive effects than (-)U50,488H (trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide). It was further found that the antinociceptive effects of ATPM were mediated by kappa- and mu-, but not delta-opioid, receptors. In addition to its agonist profile on the mu-receptor, ATPM also acted as a mu-antagonist, as measured by its inhibition of morphine-induced antinociception. It is more important that ATPM had a greater ratio of the ED(50) value of sedation to that of antinociception than (-)U50,488 (11.8 versus 3.7), indicative of a less sedative effect than (-)U50,488H. In addition, ATPM showed less potential to develop antinociceptive tolerance relative to (-)U50,488H and morphine. Moreover, it dose-dependently inhibited morphine-induced antinociceptive tolerance. Furthermore, it was found that chronic treatment of rats for 8 consecutive days with ATPM (0.5 mg/kg s.c.) produced sustained decreases in heroin self-administration. (-)U50,488H (2 mg/kg s.c.) also produced similar inhibitory effect. Taken together, our findings demonstrated that ATPM, a novel mixed kappa-agonist and mu-agonist/-antagonist, could inhibit morphine-induced antinociceptive tolerance, with less potential to develop tolerance and reduce heroin self-administration with less sedative effect. kappa-Agonists with some mu-activity appear to offer some advantages over selective kappa-agonists for the treatment of heroin abuse.",
        "keywords": [],
        "authors": [
            {
                "name": "Yu-Jun Wang",
                "org": "School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China."
            },
            {
                "name": "Yi-Min Tao",
                "org": ""
            },
            {
                "name": "Fu-Ying Li",
                "org": ""
            },
            {
                "name": "Yu-Hua Wang",
                "org": ""
            },
            {
                "name": "Xue-Jun Xu",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Ying-Lin Cao",
                "org": ""
            },
            {
                "name": "Zhi-Qiang Chi",
                "org": ""
            },
            {
                "name": "John L Neumeyer",
                "org": ""
            },
            {
                "name": "Ao Zhang",
                "org": ""
            },
            {
                "name": "Jing-Gen Liu",
                "org": ""
            }
        ],
        "venue": "The Journal of pharmacology and experimental therapeutics",
        "year": 2009
    },
    "rNGeeqe3": {
        "id": "rNGeeqe3",
        "title": "Novel recurrently mutated genes and a prognostic mutation signature in colorectal cancer.",
        "abstract": "Characterisation of colorectal cancer (CRC) genomes by next-generation sequencing has led to the discovery of novel recurrently mutated genes. Nevertheless, genomic data has not yet been used for CRC prognostication.To identify recurrent somatic mutations with prognostic significance in patients with CRC.Exome sequencing was performed to identify somatic mutations in tumour tissues of 22 patients with CRC, followed by validation of 187 recurrent and pathway-related genes using targeted capture sequencing in additional 160 cases.Seven significantly mutated genes, including four reported (APC, TP53, KRAS and SMAD4) and three novel recurrently mutated genes (CDH10, FAT4 and DOCK2), exhibited high mutation prevalence (6-14% for novel cancer genes) and higher-than-expected number of non-silent mutations in our CRC cohort. For prognostication, a five-gene-signature (CDH10, COL6A3, SMAD4, TMEM132D, VCAN) was devised, in which mutation(s) in one or more of these genes was significantly associated with better overall survival independent of tumor-node-metastasis (TNM) staging. The median survival time was 80.4\u2005months in the mutant group versus 42.4\u2005months in the wild type group (p=0.0051). The prognostic significance of this signature was successfully verified using the data set from the Cancer Genome Atlas study.The application of next-generation sequencing has led to the identification of three novel significantly mutated genes in CRC and a mutation signature that predicts survival outcomes for stratifying patients with CRC independent of TNM staging.",
        "keywords": [
            "colonic neoplasms",
            "colon cancer"
        ],
        "authors": [
            {
                "name": "Jun Yu",
                "org": ""
            },
            {
                "name": "William K K Wu",
                "org": ""
            },
            {
                "name": "Xiangchun Li",
                "org": ""
            },
            {
                "name": "Jun He",
                "org": ""
            },
            {
                "name": "Xiao-Xing Li",
                "org": ""
            },
            {
                "name": "Simon S M Ng",
                "org": ""
            },
            {
                "name": "Chang Yu",
                "org": ""
            },
            {
                "name": "Zhibo Gao",
                "org": ""
            },
            {
                "name": "Jie Yang",
                "org": ""
            },
            {
                "name": "Miao Li",
                "org": ""
            },
            {
                "name": "Qiaoxiu Wang",
                "org": ""
            },
            {
                "name": "Qiaoyi Liang",
                "org": ""
            },
            {
                "name": "Yi Pan",
                "org": ""
            },
            {
                "name": "Joanna H Tong",
                "org": ""
            },
            {
                "name": "Ka F To",
                "org": ""
            },
            {
                "name": "Nathalie Wong",
                "org": ""
            },
            {
                "name": "Ning Zhang",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Youyong Lu",
                "org": ""
            },
            {
                "name": "Paul B S Lai",
                "org": ""
            },
            {
                "name": "Francis K L Chan",
                "org": ""
            },
            {
                "name": "Yingrui Li",
                "org": ""
            },
            {
                "name": "Hsiang-Fu Kung",
                "org": ""
            },
            {
                "name": "Huanming Yang",
                "org": ""
            },
            {
                "name": "Jun Wang",
                "org": ""
            },
            {
                "name": "Joseph J Y Sung",
                "org": ""
            }
        ],
        "venue": "Gut",
        "year": 2015
    },
    "JduEJxZS": {
        "id": "JduEJxZS",
        "title": "Effects of phytoestrogens on testosterone production of rat Leydig cells]",
        "abstract": "To investigate the effects of phytoestrogens (daidzein and genistein) on the testosterone production of rat Leydig cells and the possible mechanisms.Primary Leydig cells were obtained from 3-month old male SD rats using discontinuous Percoll density gradient centrifugation. The effects of phytoestrogens at various concentrations were evaluated by ELISA, with hCG as the positive control. The mRNA expression of P450 side-chain cleavage enzyme (P450scc) was analyzed by semi-quantitative RT-PCR.Genistein at 0.1 micromol/L obviously promoted the secretion of testosterone and upregulated the mRNA level of P450scc. At a higher concentration of 5 micromol/L, however, both daidzein and genistein significantly inhibited the testosterone production of Leydig cells (P > 0.05).Genistein can promote the testosterone production of Leydig cells at a low concentration (0.1 micromol/L), but both daidzein and genistein can inhibit it at a higher concentration ( >5 micromol/L).",
        "keywords": [
            "leydig cell",
            "genistein",
            "testosterone",
            "daidzein",
            "p450 side-chain cleavage enzyme"
        ],
        "authors": [
            {
                "name": "Feng-rong Zhu",
                "org": "Research Center,Tianjin Tiens Group,Tianjin ,China"
            },
            {
                "name": "Yong-gang Wang",
                "org": "Research Center,Tianjin Tiens Group,Tianjin ,China;Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai ,China"
            },
            {
                "name": "Jie Chen",
                "org": "Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai ,China"
            },
            {
                "name": "Yan-xue Hu",
                "org": "Research Center,Tianjin Tiens Group,Tianjin ,China"
            },
            {
                "name": "Fu-sen Han",
                "org": "Research Center,Tianjin Tiens Group,Tianjin ,China"
            },
            {
                "name": "He-yao Wang",
                "org": "Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai ,China"
            }
        ],
        "venue": "Zhonghua nan ke xue = National journal of andrology",
        "year": 2009
    },
    "PmzUGP86": {
        "id": "PmzUGP86",
        "title": "INVOLVEMENT OF ATTENUATION OF Na~+,K~+-ATPase ACTIVITY AND DECREMENT OF ENERGY METABOLISM ENZYME EXPRESSION IN THE DEVELOPMENT OF MORPHINE DEPENDENCE",
        "abstract": "Accumulating evidence has demonstrated that the hippocampus contributes to the development of opioid dependence.However,the mechanisms underlying the role of the hippocampus in opioid dependence are to be determined.Here,we demonstrated that chronic exposure of mice to morphine for 10 days resulted in a significant attenuation of Na~+,K~+-ATPase activity via up-regulation of cAMP/PKA signal pathway.Given the previous findings that the depolarization of neurons induced by impairment of Na~+,K~+-ATPase activity is involved in the development of opioid dependence,these findings suggest that diminution of Na~+,K~+-ATPase mediated by up-regulated cAMP/PKA cascade may be a potential mechanism underlying opioid dependence.In addition,we also found that chronic morphine treatment led to a remarkable down-regulation of the protein level of three energy metabolism enzymes.The failure of conversion of glucose into ATP was also observed in the chronic morphine-treated but not acute morphine-treated mice hippocampus.Intra-hippocampal injection of D-glucose but not non-metabolizable sugar 3-O-methyl-glucose prior to morphine administration significantly suppressed naloxone-precipitated withdrawal jumping in acute morphine-treated mice.However,intra-hippocampal injection of glucose was unable to suppress naloxone-precipitated withdrawal jumping in chronic morphine-treated mice.These results demonstrated that the down-regulations of the hippocampal energy metabolism protein expression and impairment of glucose metabolism were also involved in the development of morphine dependence.",
        "keywords": [
            "morphine",
            "Na~+",
            "learning and memory",
            "glucose",
            "hippocampus",
            "K~+-ATPase",
            "dependence"
        ],
        "authors": [
            {
                "name": "WU Zhaoqiu",
                "org": "State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,"
            },
            {
                "name": "CHEN Xiaolan",
                "org": "State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,"
            },
            {
                "name": "LU Gang",
                "org": "State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,"
            },
            {
                "name": "CHEN Jie",
                "org": "State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,"
            },
            {
                "name": "CHI Zhiqiang",
                "org": "State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,"
            },
            {
                "name": "LIU Jinggen",
                "org": "State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai,"
            }
        ],
        "venue": "Chinese Journal of Drug Dependence",
        "year": 2006
    },
    "KrLnQrNl": {
        "id": "KrLnQrNl",
        "title": "Role of Src in ligand-specific regulation of delta-opioid receptor desensitization and internalization.",
        "abstract": "The opioid receptors are a member of G protein-coupled receptors that mediate physiological effects of endogenous opioid peptides and structurally distinct opioid alkaloids. Although it is well characterized that there is differential receptor desensitization and internalization properties following activation by distinct agonists, the underlying mechanisms remain elusive. We investigated the signaling events of delta-opioid receptor (deltaOR) initiated by two ligands, DPDPE and TIPP. We found that although both ligands inhibited adenylyl cyclase (AC) and activated ERK1/2, only DPDPE induced desensitization and internalization of the deltaOR. We further found that DPDPE, instead of TIPP, could activate GRK2 by phosphorylating the non-receptor tyrosine kinase Src and translocating it to membrane receptors. Activation of GRK2 led to the phosphorylation of serine residues in the C-terminal tail, which facilitates beta-arrestin1/2 membrane translocation. Meanwhile, we also found that DPDPE promoted beta-arrestin1 dephosphorylation in a Src-dependent manner. Thus, DPDPE appears to strengthen beta-arrestin function by dual regulations: promoting beta-arrestin recruitment and increasing beta-arrestin dephosphorylation at the plasma membrane in a Src-dependent manner. All effects initiated by DPDPE could be abolished or suppressed by PP2, an inhibitor of Src. Morphine, which has been previously shown to be unable to desensitize or internalize deltaOR, also behaved as TIPP in failure to utilize Src to regulate deltaOR signaling. These findings point to the existence of agonist-specific utilization of Src to regulate deltaOR signaling and reveal the molecular events by which Src modulates deltaOR responsiveness.",
        "keywords": [],
        "authors": [
            {
                "name": "Min-Hua Hong",
                "org": "State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China."
            },
            {
                "name": "Chi Xu",
                "org": ""
            },
            {
                "name": "Yu-Jun Wang",
                "org": ""
            },
            {
                "name": "Jing-Li Ji",
                "org": ""
            },
            {
                "name": "Yi-Min Tao",
                "org": ""
            },
            {
                "name": "Xue-Jun Xu",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Xin Xie",
                "org": ""
            },
            {
                "name": "Zhi-Qiang Chi",
                "org": ""
            },
            {
                "name": "Jing-Gen Liu",
                "org": ""
            }
        ],
        "venue": "Journal of neurochemistry",
        "year": 2009
    },
    "E2riMOlf": {
        "id": "E2riMOlf",
        "title": "Adenosine A(1) receptor agonist N(6)-cyclohexyl-adenosine induced phosphorylation of delta opioid receptor and desensitization of its signaling.",
        "abstract": "To define the effect of adenosine A(1) receptor (A(1)R) on delta opioid receptor (DOR)-mediated signal transduction.CHO cells stably expressing HA-tagged A(1)R and DOR-CFP fusion protein were used. The localization of receptors was observed using confocal microscope. DOR-mediated inhibition of adenylyl cyclase was measured using cyclic AMP assay. Western blots were employed to detect the phosphorylation of Akt and the DOR. The effect of A(1)R agonist N(6)-cyclohexyladenosine (CHA) on DOR down-regulation was assessed using radioligand binding assay.CHA 1 micromol/L time-dependently attenuated DOR agonist [D-Pen(2,5)]enkephalin (DPDPE)-induced inhibition of intracellular cAMP accumulation with a t(1/2)=2.56 (2.09-3.31) h. Pretreatment with 1 micromol/L CHA for 24 h caused a right shift of the dose-response curve of DPDPE-mediated inhibition of cAMP accumulation, with a significant increase in EC(50) but no change in E(max). Pretreatment with 1 micromol/L CHA for 1 h also induced a significant attenuation of DPDPE-stimulated phosphorylation of Akt. Moreover, CHA time-dependently phosphorylated DOR (Ser363), and this effect was inhibited by A(1)R antagonist 1,3-Dipropyl-8-cyclopentylxanthine (DPCPX) but not by DOR antagonist naloxone. However, CHA failed to produce the down-regulation of DOR, as neither receptor affinity (K(d)) nor receptor density (B(max)) of DOR showed significant change after chronic CHA exposure.Activation of A(1)R by its agonist caused heterologous desensitization of DOR-mediated inhibition of intracellular cAMP accumulation and phosphorylation of Akt. Activation of A(1)R by its agonist also induced heterologous phosphorylation but not down-regulation of DOR.",
        "keywords": [],
        "authors": [
            {
                "name": "Yun Cheng",
                "org": "Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China."
            },
            {
                "name": "Yi-min Tao",
                "org": ""
            },
            {
                "name": "Jian-feng Sun",
                "org": ""
            },
            {
                "name": "Yu-hua Wang",
                "org": ""
            },
            {
                "name": "Xue-jun Xu",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Zhi-qiang Chi",
                "org": ""
            },
            {
                "name": "Jing-gen Liu",
                "org": ""
            }
        ],
        "venue": "Acta pharmacologica Sinica",
        "year": 2010
    },
    "Mnqh3f56": {
        "id": "Mnqh3f56",
        "title": "LPK-26, a novel kappa-opioid receptor agonist with potent antinociceptive effects and low dependence potential.",
        "abstract": "Analgesics such as morphine cause many side effects including addiction, but kappa-opioid receptor agonist can produce antinociception without morphine-like side effects. With the aim of developing new and potent analgesics with lower abuse potential, we studied the antinociceptive and physical dependent properties of a derivate of ICI-199441, an analogue of (-)U50,488H, named (2-(3,4-dichloro)-phenyl)-N-methyl-N-[(1S)-1-(2-isopropyl)-2-(1-(3-pyrrolinyl))ethyl] acetamides (LPK-26). LPK-26 showed a high affinity to kappa-opioid receptor with the Ki value of 0.64 nM and the low affinities to micro-opioid receptor and delta-opioid receptor with the Ki values of 1170 nM and >10,000 nM, respectively. It stimulated [(35)S]GTPgammaS binding to G-proteins with an EC50 value of 0.0094 nM. In vivo, LPK-26 was more potent than (-)U50,488H and morphine in analgesia, with the ED50 values of 0.049 mg/kg and 0.0084 mg/kg in hot plat and acetic acid writhing tests, respectively. Moreover, LPK-26 failed to induce physical dependence, but it could suppress naloxone-precipitated jumping in mice when given simultaneously with morphine. Taken together, our results show that LPK-26 is a novel selective kappa-opioid receptor agonist with highly potent antinociception effects and low physical dependence potential. It may be valuable for the development of analgesic and drug that can be used to reduce morphine-induced physical dependence.",
        "keywords": [],
        "authors": [
            {
                "name": "Yi-Min Tao",
                "org": "State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China."
            },
            {
                "name": "Qing-Lin Li",
                "org": ""
            },
            {
                "name": "Cong-Fen Zhang",
                "org": ""
            },
            {
                "name": "Xue-Jun Xu",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Ya-Wen Ju",
                "org": ""
            },
            {
                "name": "Zhi-Qiang Chi",
                "org": ""
            },
            {
                "name": "Ya-Qiu Long",
                "org": ""
            },
            {
                "name": "Jing-Gen Liu",
                "org": ""
            }
        ],
        "venue": "European journal of pharmacology",
        "year": 2008
    },
    "0UMXrSQo": {
        "id": "0UMXrSQo",
        "title": "Novel \u03ba-opioid receptor agonist MB-1C-OH produces potent analgesia with less depression and sedation.",
        "abstract": "To characterize the pharmacological profiles of a novel \u03ba-opioid receptor agonist MB-1C-OH.[(3)H]diprenorphine binding and [(35)S]GTP\u03b3S binding assays were performed to determine the agonistic properties of MB-1C-OH. Hot plate, tail flick, acetic acid-induced writhing, and formalin tests were conducted in mice to evaluate the antinociceptive actions. Forced swimming and rotarod tests of mice were used to assess the sedation and depression actions.In [(3)H]diprenorphine binding assay, MB-1C-OH did not bind to \u03bc- and \u03b4-opioid receptors at the concentration of 100 \u03bcmol/L, but showed a high affinity for \u03ba-opioid receptor (Ki=35 nmol/L). In [(35)S]GTP\u03b3S binding assay, the compound had an Emax of 98% and an EC50 of 16.7 nmol/L for \u03ba-opioid receptor. Subcutaneous injection of MB-1C-OH had no effects in both hot plate and tail flick tests, but produced potent antinociception in the acetic acid-induced writhing test (ED50=0.39 mg/kg), which was antagonized by pretreatment with a selective \u03ba-opioid receptor antagonist Nor-BNI. In the formalin test, subcutaneous injection of MB-1C-OH did not affect the flinching behavior in the first phase, but significantly inhibited that in the second phase (ED50=0.87 mg/kg). In addition, the sedation or depression actions of MB-1C-OH were about 3-fold weaker than those of the classical \u03ba agonist (-)U50,488H.MB-1C-OH is a novel \u03ba-opioid receptor agonist that produces potent antinociception causing less sedation and depression.",
        "keywords": [],
        "authors": [
            {
                "name": "Le-sha Zhang",
                "org": "State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica and Collaborative Innovation Center for Brain Science, Chinese Academy of Sciences, Shanghai 201203, China."
            },
            {
                "name": "Jun Wang",
                "org": "1] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica and Collaborative Innovation Center for Brain Science, Chinese Academy of Sciences, Shanghai 201203, China [2] Biotechnology Center, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China."
            },
            {
                "name": "Jian-chun Chen",
                "org": "Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China."
            },
            {
                "name": "Yi-min Tao",
                "org": "State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica and Collaborative Innovation Center for Brain Science, Chinese Academy of Sciences, Shanghai 201203, China."
            },
            {
                "name": "Yu-hua Wang",
                "org": "1] Biotechnology Center, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China [2] School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China."
            },
            {
                "name": "Xue-jun Xu",
                "org": "State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica and Collaborative Innovation Center for Brain Science, Chinese Academy of Sciences, Shanghai 201203, China."
            },
            {
                "name": "Jie Chen",
                "org": "State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica and Collaborative Innovation Center for Brain Science, Chinese Academy of Sciences, Shanghai 201203, China."
            },
            {
                "name": "Yun-gen Xu",
                "org": "Biotechnology Center, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China."
            },
            {
                "name": "Tao Xi",
                "org": "Biotechnology Center, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China."
            },
            {
                "name": "Xiao-wu Hu",
                "org": "Department of Neurosurgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China."
            },
            {
                "name": "Yu-jun Wang",
                "org": "State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica and Collaborative Innovation Center for Brain Science, Chinese Academy of Sciences, Shanghai 201203, China."
            },
            {
                "name": "Jing-gen Liu",
                "org": "State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica and Collaborative Innovation Center for Brain Science, Chinese Academy of Sciences, Shanghai 201203, China."
            }
        ],
        "venue": "Acta pharmacologica Sinica",
        "year": 2015
    },
    "WD1nRUwM": {
        "id": "WD1nRUwM",
        "title": "\u03b2-lactamases,porin and efflux pump encoding genes in pandrug-resistant Acinetobacter baumannii isolates",
        "abstract": "OBJECTIVE To investigate the prevalence of \u03b2-lactamase,porin and efflux pump encoding genes in isolates of pandrug-resistant Acinetobacter baumannii(PDR-ABA).METHODS A total of 33 types of \u03b2-lactamase genes including 13 types of A,10 types of B,2 types of C,8 types of D,the porin carO,and efflux pump adeB from 20 isolates of PDR-ABA were detected by PCR.RESULTS Among \u03b2-lactamase encoding genes,the detection rates of TEM-1(type A) and ADC-30(type C) were both 100.0%,the positive rate of OXA-23(type D)was 65.0%,with no gene of type B detected.The positive rates of porin carO and efflux pump adeB from 20 isolates of PDRAB were both 100.0%.CONCLUSION Clinical isolates of PDRAB can carry many types of \u03b2-lactamase-resistant genes,and it is common to find porins and efflux pumps in those isolates.",
        "keywords": [
            "\u03b2-lactamase",
            "Porin",
            "Pandrug-Resistant",
            "Acinetobacter baumannii",
            "Efflux pump"
        ],
        "authors": [
            {
                "name": "WANG Wei-hua",
                "org": "Affiliated Hospital of Medical College of Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Affiliated Hospital of Medical College of Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "LI Chun-xian",
                "org": "Affiliated Hospital of Medical College of Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "MAO Xiong-ying",
                "org": "Affiliated Hospital of Medical College of Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "L\u00fc Wan-fei",
                "org": "Affiliated Hospital of Medical College of Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "WANG Li",
                "org": "Affiliated Hospital of Medical College of Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "CHEN Hui",
                "org": "Affiliated Hospital of Medical College of Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "MI ZU-huang",
                "org": "Affiliated Hospital of Medical College of Ningbo University,Ningbo,Zhejiang ,China"
            }
        ],
        "venue": "Chinese Journal of Nosocomiology",
        "year": 2012
    },
    "JSZ0QWb8": {
        "id": "JSZ0QWb8",
        "title": "Detection of aminoglicoside modifying enzyme gene aac(6\u2032)-\u2160b and aac(6\u2032)-\u2160b-Cr at same time in a group of escherichia coli isolates",
        "abstract": "OBJECTIVE To investigate the prevalence of acquired aminoglycoside resistance genes in multidrug-resistant Escherichia coli.METHODS 14 types of Aminoglicoside modifying enzyme genes,i.e.(aac(3)-\u2160,aac(3)-\u2161,aac(3)-\u2162,aac(3)-\u2163,aac(6\u2032)-\u2160b,aac(6\u2032)-\u2161,ant(2\u2033)-\u2160,ant(3\u2033)-\u2160,aadA4/5,aadA6/16,ant(4\u2032)-\u2160,aph(3\u2032)-\u2160,aph(3\u2032)-\u2161a,aph(3\u2032)-\u2161b),and 6 types of 16S rRNA methylase genes,i.e.armA,rmtA,rmtB,rmtC,rmtD,npmA,were detected by polymerase chain reaction(PCR),then partly were sequenced and analyzed.RESULTS Totally 5 types of Aminoglicoside modifying enzyme genes,namly aac(3)-\u2161,aac(6\u2032)-\u2160b,ant(3\u2033)-\u2160,aadA5,aph(3\u2032)-\u2160 were existed,positive rates were 25.0%,25.0%,5.0%,65.0% and 55.0% respectively,whereas the others were all negative.For 5 strains of aac(6\u2032)-\u2160b,4 strains were actually aac(6\u2032)-\u2160b-cr,verified by means of BLASTn.CONCLUSION The aminoglycoside resistance mechanism of multi-drug-resistant E.coli isolates is not related with 16S rRNA methylase,but closely related to aminoglycoside-modifying enzymes.",
        "keywords": [
            "Modifying enzyme gene",
            "Aminoglicoside",
            "Escherichia coli",
            "Methylase gene"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "The Affiliated Hospital of Medical College in Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "WANG Wei-hua",
                "org": "The Affiliated Hospital of Medical College in Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "WANG Li",
                "org": "The Affiliated Hospital of Medical College in Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "LV Wan-fei",
                "org": "The Affiliated Hospital of Medical College in Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "ZHANG Yuan-yuan",
                "org": "The Affiliated Hospital of Medical College in Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "MAO Xiong-ying",
                "org": "The Affiliated Hospital of Medical College in Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "CHEN Hui",
                "org": "The Affiliated Hospital of Medical College in Ningbo University,Ningbo,Zhejiang ,China"
            }
        ],
        "venue": "Chinese Journal of Nosocomiology",
        "year": 2011
    },
    "ItJMCwR9": {
        "id": "ItJMCwR9",
        "title": "Lack of association between a functional polymorphism (rs1800796) in the interleukin-6 gene promoter and lung cancer.",
        "abstract": "A number of studies have examined the association between interleukin-6 (IL-6) rs1800796 polymorphism and risk of lung cancer but revealed inconsistent results. The aim of this study was to clarify the association between IL-6 rs1800796 polymorphism and risk of lung cancer.Literature databases including PubMed, Embase and CNKI were searched up to January 2014. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) under co-dominant model, dominant model and recessive model were estimated using random-effects model.A total of seven studies, including 2691 lung cancer cases and 3067 controls, were included in the meta-analysis. The results suggested that IL-6 rs1800796 polymorphism was not associated with risk of lung cancer under homogeneous co-dominant model (OR\u2009=\u20091.06, 95%CI\u2009=\u20090.73-1.54), heterogeneous co-dominant model (OR\u2009=\u20091.24, 95%CI\u2009=\u20090.96-1.60), dominant model (OR\u2009=\u20091.23, 95%CI\u2009=\u20090.95-1.58) and recessive model (OR\u2009=\u20090.96, 95%CI\u2009=\u20090.70-1.32). The association was still not significant in either never-smokers (OR\u2009=\u20091.19, 95%CI\u2009=\u20090.95-1.48) or ever-smokers (OR\u2009=\u20091.73, 95%CI\u2009=\u20090.89-3.36).The present meta-analysis suggested that there was no association between IL-6 rs1800796 polymorphism and lung cancer, which was independent of smoking status.The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1060061508127855.",
        "keywords": [
            "Interleukin-6",
            " Lung cancer",
            " Polymorphism",
            " Meta-analysis"
        ],
        "authors": [
            {
                "name": "Weihua Wang",
                "org": "The Affiliated Hospital of Medical College of Ningbo University, Ningbo 315020 Zhejiang, China. wangweihua2014@126.com."
            },
            {
                "name": "Jie Chen",
                "org": "The Affiliated Hospital of Medical College of Ningbo University,Ningbo,China"
            },
            {
                "name": "Feng Zhao",
                "org": "The Affiliated Hospital of Medical College of Ningbo University,Ningbo,China"
            },
            {
                "name": "Burong Zhang",
                "org": "The Affiliated Hospital of Medical College of Ningbo University,Ningbo,China"
            },
            {
                "name": "Hongsheng Yu",
                "org": "The Affiliated Hospital of Medical College of Ningbo University,Ningbo,China"
            }
        ],
        "venue": "Diagnostic pathology",
        "year": 2014
    },
    "O2givxI1": {
        "id": "O2givxI1",
        "title": "MiR-150-5p suppresses colorectal cancer cell migration and invasion through targeting MUC4.",
        "abstract": "Growing evidence suggests that miR-150-5p has an important role in regulating genesis of various types of cancer. However, the roles and the underlying mechanisms of miR-150-5p in development of colorectal cancer (CRC) remain largely unknown. Transwell chambers were used to analyze effects on cell migration and invasion by miR-150-5p. Quantitative real-time PCR (qRT-PCR), Western blotting and dual-luciferase 3' UTR reporter assay were carried out to identify the target genes of miR-150-5p. In our research, miR-150-5p suppressed CRC cell migration and invasion, and MUC4 was identified as a direct target gene. Its effects were partly blocked by re-expression of MUC4. In conclusiomn, miR-150-5p may suppress CRC metastasis through directly targeting MUC4, highlighting its potential as a novel agent for the treatment of CRC metastasis.",
        "keywords": [
            "muc4",
            "colorectal cancer"
        ],
        "authors": [
            {
                "name": "Wei-Hua Wang",
                "org": "Department of Clinical Laboratory, The Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China E-mail : jinhua_dainb@126.com."
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Feng Zhao",
                "org": ""
            },
            {
                "name": "Bu-Rong Zhang",
                "org": ""
            },
            {
                "name": "Hong-Sheng Yu",
                "org": ""
            },
            {
                "name": "Hai-Ying Jin",
                "org": ""
            },
            {
                "name": "Jin-Hua Dai",
                "org": ""
            }
        ],
        "venue": "Asian Pacific journal of cancer prevention : APJCP",
        "year": 2014
    },
    "H8586ks3": {
        "id": "H8586ks3",
        "title": "A plasmonic random laser tunable through stretching silver nanowires embedded in a flexible substrate.",
        "abstract": "A mechanically-tunable random laser based on a waveguide-plasmonic scheme has been investigated. This laser can be constructed by spin coating a solution of polydimethylsiloxane doped with the rhodamine 6G organic dye and silver nanowires onto a silicone rubber slab. The excellent overlap of the plasmon resonance peak of the silver nanowires with both the pump wavelength and the photoluminescence spectrum provides the low threshold and tuning properties of the random laser. The random laser wavelength can be tuned from 558 to 565 nm by stretching the soft substrate, which causes reorientation and breakage of the silver nanowires. The polarization state of the random laser can also be changed from random polarization to partial polarization by stretching. The laser performance remains unchanged after the stretching and restoration experiments. These results not only enable easy realization of an ultrathin flexible plasmonic random laser but also provide insights into the mechanisms of three-dimensional plasmonic feedback random lasers.",
        "keywords": [],
        "authors": [
            {
                "name": "Tianrui Zhai",
                "org": "Institute of Information Photonics Technology and College of Applied Sciences, Beijing University of Technology, Beijing 100124, China. trzhai@bjut.edu.cn zhangxinping@bjut.edu.cn."
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Li Chen",
                "org": ""
            },
            {
                "name": "Jieyu Wang",
                "org": ""
            },
            {
                "name": "Li Wang",
                "org": ""
            },
            {
                "name": "Dahe Liu",
                "org": ""
            },
            {
                "name": "Songtao Li",
                "org": ""
            },
            {
                "name": "Hongmei Liu",
                "org": ""
            },
            {
                "name": "Xinping Zhang",
                "org": ""
            }
        ],
        "venue": "Nanoscale",
        "year": 2015
    },
    "J6K4mazc": {
        "id": "J6K4mazc",
        "title": "Plasmid-mediated AmpC \u03b2-Lactamases Genes in Enterobacter cloacae in Ningbo Area and Preliminary Discovery of a New ACT-1 Subtype:An Epidemic Surveillance",
        "abstract": "OBJECTIVE To investigate the prevalence and genotype of plasmid-mediated AmpC \u03b2-lactamases genes in Enterobacter cloacae strains isolated from Ningbo area.METHODS All isolated E.cloacae strains were subjected by polymerase chain reaction(PCR),and some of the fragments produced by PCR were sequenced and analyzed.RESULTS For 85 strains,the total positive rate of plasmid-mediated AmpC genes was 32.9%,and the positive rates of DHA and ACT-1 genotypes were 29.4% and 3.5%,respectively.CONCLUSIONS The main genotype of plasmid mediated AmpC genes in Ningbo area is DHA,and the second is ACT-1;furthermore,the ACT-1 gene may be a new subtype that worth to be further studied.",
        "keywords": [
            "AmpC \u03b2-lactamase",
            "Enterobacter cloacae",
            "Gene",
            "Plasmid"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "*Affiliated Hospital,Medical College of Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "WANG Wei-hua",
                "org": "*Affiliated Hospital,Medical College of Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "MAO Xiong-ying",
                "org": "*Affiliated Hospital,Medical College of Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "XU Xiao-min",
                "org": "*Affiliated Hospital,Medical College of Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "HUANG Zhi-gang",
                "org": "*Affiliated Hospital,Medical College of Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "SUN Jun",
                "org": "*Affiliated Hospital,Medical College of Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "WANG Li",
                "org": "*Affiliated Hospital,Medical College of Ningbo University,Ningbo,Zhejiang ,China"
            }
        ],
        "venue": "Chinese Journal of Nosocomiology",
        "year": 2007
    },
    "EW6Ok9dy": {
        "id": "EW6Ok9dy",
        "title": "Disinfectant Resistant Gene in Staphylococcus aureus Isolated from Hospital Acquired Infections and Community Acquired Infections: A Preliminary Analysis",
        "abstract": "OBJECTIVE To compare the epidemicity of disinfectant resistant gene among Staphylococcus aureus (SA) and meticillin-resistant S.aureus(MRSA) isolates from hospital acquired infections(HAI) and community acquired infections(CAI). METHODS Thirty nine strains of unrepeated SA(including 24 strains of MRSA) were collected from HAI and CAI,then subjected to detection for disinfectant resistant gene qacA/B by polymerase chain reaction(PCR),and the positive rates between different groups were compared. RESULTS The positive rates of qacA/B gene detected from SA strains in HAI and CAI groups were 52.2% and 18.8%,respectively,which was significantly different(P=0.0151,<0.05);The qacA/B gene positive rates in MRSA groups were 58.8%(HAI) and 0.0%(CAI),there was also a significant difference between them((P=0.0099,<0.01)),too. CONCLUSIONS The qacA/B gene is more epidemical in SA strains from HAI than that of CAI group,this may be due to high disinfectant selective pressure in hospital surroundings,and/or a more rapid transmitting speed for a qacA/B gene positive strain in hospital than in community.",
        "keywords": [
            "Community acquired infections",
            "Disinfectant resistant gene",
            "Hospital acquired infections",
            "Staphylococcus aureus"
        ],
        "authors": [
            {
                "name": "WANG Wei-hua",
                "org": "*Affiliated Hospital of Medical College,Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "*Affiliated Hospital of Medical College,Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "WANG Li",
                "org": "*Affiliated Hospital of Medical College,Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "MAO Xiong-ying",
                "org": "*Affiliated Hospital of Medical College,Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "XU Xiao-min",
                "org": "*Affiliated Hospital of Medical College,Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "DENG Zai-chun",
                "org": "*Affiliated Hospital of Medical College,Ningbo University,Ningbo,Zhejiang ,China"
            }
        ],
        "venue": "Chinese Journal of Nosocomiology",
        "year": 2006
    },
    "awkJDGLE": {
        "id": "awkJDGLE",
        "title": "Ten Types of Mobile Genetic Elements Detected from Multidrug-resistant Escherichia coli",
        "abstract": "OBJECTIVE To investigate the prevalence of mobile genetic elements in isolates of multidrug-resistant Escherichia coli.METHODS A total of 20 strains of MDR-ECO isolated from Oct 2009 to Mar 2010 were collected,10 types of mobile genetic elements were detected by polymerase chain reaction(PCR),then the results were analyzed and partly sequenced.RESULTS A total of 6 types of mobile genetic elements were found existing among 20 isolates,namely traA,trbC,tnp513,ISEcp1,IS26 and int\u21601.CONCLUSION Mobile genetic elements,such as conjugated plasmid,transposable element,and integron group \u2160,may play an important role in the multidrug-resistance of E.coli.",
        "keywords": [
            "Multidrug-resistance",
            "Gene",
            "Mobile genetic elements",
            "Escherichia coli"
        ],
        "authors": [
            {
                "name": "WANG Wei-hua",
                "org": "Affiliated Hospital,Medical College of Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Affiliated Hospital,Medical College of Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "WANG Li",
                "org": "Affiliated Hospital,Medical College of Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "ZHANG Yuan-yuan",
                "org": "Affiliated Hospital,Medical College of Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "MAO Xiong-ying",
                "org": "Affiliated Hospital,Medical College of Ningbo University,Ningbo,Zhejiang ,China"
            },
            {
                "name": "CHEN Hui",
                "org": "Affiliated Hospital,Medical College of Ningbo University,Ningbo,Zhejiang ,China"
            }
        ],
        "venue": "Chinese Journal of Nosocomiology",
        "year": 2010
    },
    "nwLWZEnd": {
        "id": "nwLWZEnd",
        "title": "Clinical Application of Flow Cytometry for Quantification of Hanta Virus Antigenemia in Patients with Hemorrhagic Fever with Renal Syndrome",
        "abstract": "The clinical value of the detection Hanta virus antigenemia in Peripheral blood mononuclear cells (PBMC) in patients with Hemorrhagic fever with renal syndrome was evaluated. Samples from 32 cases with varying degrees of HFRS were subjected to quantitative detection for HV membrane antigen in PBMC by flow cytometry. The correlation between clinical severity and positive rates was analyzed. On the first day of onset of illness, positive PBMC rates were highly different from group to group (P<0.01), which suggested a close relationship between clinical severity and the positive rate. Dynamic observations showed that in the light and moderate groups, positive rates differed significantly from day to day. This was not the case in the severe group with no statistical significance between the 7th and 10th day(P>0.05), which implied a relatively slow rate of virus elimination. Quantitative analysis of HV antigen in PBMC by FCM is a promising method in early diagnosis, individualized therapy and in evaluating the prognosis of HFRS.",
        "keywords": [
            "Flow cytometry",
            "Antigen",
            "Hemorrhagic fever with renal syndrome",
            "Hantavirus"
        ],
        "authors": [
            {
                "name": "WANG Wei-hua",
                "org": "Clinical Laboratory Center, Affiliated Hospital of Medical College, Ningbo University, Ningbo , China"
            },
            {
                "name": "WANG Feng",
                "org": "Medical Center of Ningbo City, Lihuili Hospital, Ningbo , China"
            },
            {
                "name": "CHEN Jie",
                "org": "Clinical Laboratory Center, Affiliated Hospital of Medical College, Ningbo University, Ningbo , China"
            },
            {
                "name": "WANG Li",
                "org": "Clinical Laboratory Center, Affiliated Hospital of Medical College, Ningbo University, Ningbo , China"
            },
            {
                "name": "GU Xin",
                "org": "Dart Mouth Medical College USA;Blood Center of Ningbo, Ningbo , China"
            },
            {
                "name": "ZHOU Bin-Lei",
                "org": "Clinical Laboratory Center, Affiliated Hospital of Medical College, Ningbo University, Ningbo , China"
            }
        ],
        "venue": "\u4e2d\u56fd\u75c5\u6bd2\u5b66(\u82f1\u6587\u7248)",
        "year": 2006
    },
    "BCtSFplE": {
        "id": "BCtSFplE",
        "title": "Influence of obesity and overweight on blood coagulation and metabolic indexes in patients with type 2 diabetes mellitus",
        "abstract": "Objective:To study influence of overweight and obesity on blood coagulation and metabolic disorders in patients with type 2 diabetes mellitus(T2DM).Methods: total of 248 preliminary diagnosed T2DM patients were selected.According to body mass index(BMI),they were divided into normal BMI control group(n=95),overweight group(n=87) and obesity group(n=66).Blood lipids,blood glucose and fasting insulin(FINS) were measured in all patients and homeostasis model-insulin resistance index(HOMA-IR) was calculated then.Statistical analysis was performed.Results:Compared with normal BMI control group,there were significant increase in fibrinogen [(3.37\u00b10.55) g/L vs.(4.04\u00b10.70) g/L vs.(5.20\u00b10.69) g/L],urine microalbumin [(14.46\u00b18.90) mg/g vs.(47.33\u00b142.54) mg/g vs.(104.45\u00b160.78) mg/g],fasting blood glucose [(7.15\u00b10.97) mmol/L vs.(8.84\u00b11.81) mmol/L vs.(10.06\u00b12.28) mmol/L],FINS [(10.09\u00b18.21) IU/ml vs.(14.33\u00b115.55) IU/ml vs.(19.69\u00b110.86) IU/ml],HOMA-IR[(3.19\u00b12.59) vs.(5.51\u00b15.38) vs.(8.48\u00b14.62)],TG,TC and LDL-C levels in overweight group and obesity group,and the more BMI patients were,the higher these indicators were;There were significant decrease in plasma prothrombin time [(13.33\u00b10.69)s vs.(12.74\u00b10.69)s vs.(11.43\u00b10.53)s],activated partial thromboplastin time [(37.32\u00b12.31)s vs.(36.55\u00b12.41)s vs.(34.61\u00b11.53)s] and HDL-C [(1.54\u00b11.12) mmol/L vs.(1.27\u00b10.41) mmol/L vs.(1.09\u00b10.28) mmol/L] in overweight group and obesity group(P<0.05 all).Conclusion:Overweight and obesity aggravate coagulation and metabolic disorders in patients with type 2 diabetes mellitus.It also aggravates degree of insulin resistance,the more BMI patients are,the more serious they are.",
        "keywords": [
            "Diabetes mellitus",
            "Obesity",
            "Hyperlipidemia",
            "Blood lipid",
            "type 2"
        ],
        "authors": [
            {
                "name": "XU Jin-chun",
                "org": ""
            },
            {
                "name": "CHEN Si-jiao",
                "org": ""
            },
            {
                "name": "WANG Da-nan",
                "org": "Medical Molecular Biology Research Institute of China Medical University,Key Laboratory of Cell Biology of Ministry of Health"
            },
            {
                "name": "CHEN Jie",
                "org": ""
            },
            {
                "name": "HU Yi",
                "org": ""
            },
            {
                "name": "SONG Jin-dan",
                "org": "Medical Molecular Biology Research Institute of China Medical University,Key Laboratory of Cell Biology of Ministry of Health"
            }
        ],
        "venue": "Chinese Journal of Cardiovascular Rehabilitation Medicine",
        "year": 2012
    },
    "FuefBJME": {
        "id": "FuefBJME",
        "title": "Therapeutic effect of long-term application of aldosterone antagonist in aged patients with chronic heart failure",
        "abstract": "Objective:To explore curative effect of long-term application of aldosterone antagonist(spironolactone) in aged patients with chronic heart failure(CHF).Methods:A total of 120 CHF cases were randomly divided into spironolactone group(n=66,received spironolactone 20 mg/d,based on routine anti-heart failure drug therapy) and CHF routine treatment control group(n=54);changes of left ventricular mass index(LVMI),left ventricular ejection fraction(LVEF) and BNP level before and three months after treatment were measured,compared and analyzed in two groups.Results:Total effective rate of cardiac function improvement(80%) of spironolactone group was significantly higher than that of CHF routine treatment control group(9.25%),P<0.05;compared with CHF routine treatment control group,there were significant decrease in LVMI [(340.7\u00b1 68.3) g/m2 vs.(179.6\u00b133.3) g/m2] and BNP level [(366.15\u00b123.36) pg/ml vs.(330.38\u00b111.56) pg/ml],and significant increase in LVEF [(34.11 \u00b12.71)% vs.(46.2\u00b13.9)%] in spironolactone group after three months treatment,P<0.05 all.Conclusion:Based on routine anti-heart failure drug therapy,aldosterone antagonist can decrease BNP level,inhibit ventricular remodeling,effectively improve heart function.",
        "keywords": [
            "Heart failure",
            "congestive",
            "left",
            "Natriuretic peptide",
            "brain",
            "Ventricular function",
            "Spironolactone"
        ],
        "authors": [
            {
                "name": "FAN Shu-li",
                "org": "//Teaching and Research Office for Geriatric Disease,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "CHEN Si-jiao",
                "org": "//Teaching and Research Office for Geriatric Disease,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "CHEN Jie",
                "org": "//Teaching and Research Office for Geriatric Disease,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "WU Peng-li",
                "org": "//Teaching and Research Office for Geriatric Disease,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "DENG Bao-juan",
                "org": "//Teaching and Research Office for Geriatric Disease,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "YANG Jun",
                "org": "//Teaching and Research Office for Geriatric Disease,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "QI Hong",
                "org": "//Teaching and Research Office for Geriatric Disease,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "QI Guo-xian",
                "org": "//Teaching and Research Office for Geriatric Disease,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            }
        ],
        "venue": "Chinese Journal of Cardiovascular Rehabilitation Medicine",
        "year": 2012
    },
    "OQkNSZCs": {
        "id": "OQkNSZCs",
        "title": "Apoptosis of renal cells induced by TNF-\u03b1 and NF-\u03baB in diabetic rats and intervention of rapamycin",
        "abstract": "Objective:To investigate the apoptosis of renal cells induced by tumor necrosis factor alpha(TNF-\u03b1) and nuclear factor-\u03baB(NF-\u03baB) in diabetic rats and intervention of rapamycin.Methods:A total of 20 rats(Goto-Kakizaki rats) with type 2 diabetes mellitus(T2DM) were randomly and equally divided into DM model group(DM group) and rapamycin treatment group(DMR group,received rapamycin treatment after DM model was established);another 10 Wistar male rats were regard as normal control group.Apoptosis of renal cells,expression levels of TNF-\u03b1 and NF-\u03baB and levels of blood lipids,blood glucose were measured in all groups after four weeks and eight weeks.Results:Four and eight weeks after model was established,compared with normal control group and DMR group,there were significant increase in renal cells apoptosis and expressions of NF-\u03baB p65 and TNF-\u03b1 in DM group(P<0.01 all).Correlation analysis indicated that there were positive correlations between renal NF-\u03baB p65 and TNF-\u03b1,among RCA and TNF-\u03b1,NF-\u03baB p65(r=0.956,0.953,0.886,P<0.01 all).Conclusion:Renal cells apoptosis significant increase in rats with T2DM,but renal cells apoptosis significant decrease in DMR group,protection mechanism of rapamycin may be NF-\u03baB\u3001TNF-\u03b1 inhibiting renal cells apoptosis.",
        "keywords": [
            "Rats",
            "Sirolimus",
            "Diabetes mellitus",
            "Apoptosis",
            "type 2"
        ],
        "authors": [
            {
                "name": "XU Jin-chun",
                "org": "//1.Teaching and Research Office for Geriatric Disease,Department of Cadres Medical work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "CHEN Si-jiao",
                "org": "//1.Teaching and Research Office for Geriatric Disease,Department of Cadres Medical work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "XIONG Ying",
                "org": "//1.Teaching and Research Office for Geriatric Disease,Department of Cadres Medical work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "CHEN Jie",
                "org": "//1.Teaching and Research Office for Geriatric Disease,Department of Cadres Medical work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "SONG Jin-dan",
                "org": "Medical Molecular Biology Research Institute of China Medical University,Key Laboratory of Cell Biology of Ministry of Health"
            }
        ],
        "venue": "Chinese Journal of Cardiovascular Rehabilitation Medicine",
        "year": 2012
    },
    "T778sa1j": {
        "id": "T778sa1j",
        "title": "Type 2 Diabetes the NF-\u03ba B Pathway Microvascular Endothelial Injury and Modified Function",
        "abstract": "The NF-\u03baB pathway continuous activation plays a key role in blood vessels inflammatory reaction and excessive proliferation of endomembrane,which may be one of the initiating mechanisms of diabetes vascular endothelial cell injury and subsequent diabetic vascular lesions.NF-\u03baB related peripheral blood lymphocyte DNA oxidative damage and different signals of downstream impact factor of type 2 diabetes patients microvascular type 2 diabetes,provides the basis for early intervention of microvascular pathological changes,.It is probably that sumoylation positively regulates insulin receptor signals to prevent diabetes through the complex regulation of NF-\u03baB signal pathway.",
        "keywords": [
            "NF-\u03baB signaling pathways",
            "Microvascular endothelial injury",
            "Type 2 diabetes",
            "Modified function"
        ],
        "authors": [
            {
                "name": "YANG Hong-yan",
                "org": "Gerontology Research Laboratory,the First Affiliated Hospital of China Medical University,Shenyang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Gerontology Research Laboratory,the First Affiliated Hospital of China Medical University,Shenyang ,China"
            },
            {
                "name": "CHEN Si-jiao",
                "org": "Gerontology Research Laboratory,the First Affiliated Hospital of China Medical University,Shenyang ,China"
            },
            {
                "name": "SONG Jin-dan",
                "org": "Medical Molecular Biology Research Institute of China Medical University,Key Laboratory of Cell Biology of Ministry of Health,Shenyang ,China"
            }
        ],
        "venue": "Medical Recapitulate",
        "year": 2012
    },
    "yj9DJjeF": {
        "id": "yj9DJjeF",
        "title": "Study for risk factors of NAFLD and ED in patients with metabolic syndrome among large sample population from northern cities of China",
        "abstract": "Objective:To study risk factors for non-alcoholic fatty liver disease(NAFLD) and vascular erectile dysfunction(ED) in patients with metabolic syndrome(MS).Methods:A total of 18 096 subjects were selected from people undergoing physical examination from 2008 to 2009 in northern cities of China by random cluster sampling method,and analyzed the risk factors for NAFLD and ED.Results: The 18 096 cases with age 18~76(46.8\u00b110.1) years old,containng 10 096(55.79%) males and 8 000(44.21%) females.Awareness rate of MS was 8.33% and prevalence rate of MS in healthy adults was 21.18%.Most common components of MS were hyperuricemia(27%),obesity and overweight(21%),hypertension(20%) and dyslipidemia(17%) in turn.Body mass index(BMI,kg/m2) and waist/hip ratio(WHR) of all MS subgroups from high to low were ED group [(28.9\u00b11.1),(1.26\u00b10.03)],overweight or obesity group [(27.5\u00b12.3),(1.31\u00b10.03)],prediabetes group [(26.8\u00b12.6),(1.03\u00b10.03)] and hypertension group [(26.1\u00b11.3),(0.90\u00b10.04)] in turn.A total of 3 721 MS patients(20.56%)complicated with NAFLD;By means of NAFLD complicated by MS as dependent variable,Logistic regression analysis indicated that increased ALT,waist circumference(WC),age,DM family history,LDL-C and BMI(\u03b2=1.004~0.479,P=0.000~0.016 in turn) were risk factors for NAFLD,and physical exercise and occupational physical work were protective factors for NAFLD.There were 106 ED males and its prevalence rate was 1.04%;Logistic regression analysis indicated that age,WC,LDL-C,DM family history and BMI(\u03b2=0.681~0.238,P=0.000~0.018 in turn) were risk factors for ED,and educational degree,physical exercise and occupational physical work were protective factors for ED.Conclusion:Risk factors for NAFLD and ED in MS were closely correlated with MS.It's a new path to prevent and treat NAFLD and ED through correcting risk factors of MS.",
        "keywords": [
            "Metabolic syndrome",
            "Impotence",
            "Fatty liver"
        ],
        "authors": [
            {
                "name": "XU Jin-chun",
                "org": "//1.Teaching and Research Office for Geriatric Disease,Department of Cadres Medical work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "CHEN Si-jiao",
                "org": "//1.Teaching and Research Office for Geriatric Disease,Department of Cadres Medical work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "WANG Wei",
                "org": "Physical examination center of the First Affiliated Hospital of China Medical University Shenyang,China"
            },
            {
                "name": "ZHANG Hao",
                "org": "Physical examination center of the First Affiliated Hospital of China Medical University Shenyang,China"
            },
            {
                "name": "CHEN Jie",
                "org": "//1.Teaching and Research Office for Geriatric Disease,Department of Cadres Medical work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "WANG Tong-cai",
                "org": "//1.Teaching and Research Office for Geriatric Disease,Department of Cadres Medical work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "WU Peng-li",
                "org": "//1.Teaching and Research Office for Geriatric Disease,Department of Cadres Medical work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "ZHAO Yi-ting",
                "org": "Medical Molecular Biology Research Institute of China Medical University,Key Laboratory of Cell Biology of Ministry of Health"
            },
            {
                "name": "CHENG Xin",
                "org": "Medical Molecular Biology Research Institute of China Medical University,Key Laboratory of Cell Biology of Ministry of Health"
            },
            {
                "name": "HE Qian",
                "org": "Medical Molecular Biology Research Institute of China Medical University,Key Laboratory of Cell Biology of Ministry of Health"
            },
            {
                "name": "SONG Jin-dan",
                "org": "Medical Molecular Biology Research Institute of China Medical University,Key Laboratory of Cell Biology of Ministry of Health"
            }
        ],
        "venue": "Chinese Journal of Cardiovascular Rehabilitation Medicine",
        "year": 2012
    },
    "JT57VwBx": {
        "id": "JT57VwBx",
        "title": "Relationship between metabolic syndrome and five-year cumulative onset risk of cardiovascular event among health-examination people in city of Liaoning province",
        "abstract": "Objective:To prospectively study relationship between metabolic syndrome(MS) and onset risk of cardiovascular event.Methods:Subjects were selected from first affiliated hospital of China Medical University.A total of 300 cases diagnosed as MS were randomly selected from examination peoples,and they were followed up for five years from 2006 to 2011.Results:A total of 270 cases were enrolled in the study,including 227 males and 43 females with age(56.23\u00b118.15) years.After age standardization,cumulative incidence rate of cardiovascular events in five years was 9.88%,the baseline level of high sensitive C reactive protein(hsCRP) was stratified into four layers,Logistic regression analysis show that there were tendency i.e.both in male and female,cumulative incidence rate of cardiovascular events gradually elevate as hsCRP level increase(P<0.01),after adjustments for baseline age,hypertension,low-density lipoprotein cholesterol,high density lipoprotein cholesterol,triglyceride,blood glucose(FBG/PBG),smoking and abdominal obesity,onset risk of cardiovascular event in male and female with hsCRP \u22653 mg/L were 1.98 times(95%CI: 1.15~5.77) and 1.95 times(95%CI: 1.13~5.39) for those of male and female with hsCRP<1 mg/L respectively.Conclusion:Baseline level of hsCRP is an independent predictor of cardiovascular event in people with metabolic syndrome,suggesting that chronic inflammation plays an important role in the pathological process of cardiovascular event in people with metabolic syndrome.",
        "keywords": [
            "Prospective studies",
            "Metabolic syndrome",
            "Cardiovascular diseases",
            "C-reactive protein"
        ],
        "authors": [
            {
                "name": "XU Jin-chun",
                "org": "//Teaching and Research Office for Geriatric Disease,Department of Cadres Medical Work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "CHEN Si-jiao",
                "org": "//Teaching and Research Office for Geriatric Disease,Department of Cadres Medical Work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "ZHANG Hao",
                "org": ""
            },
            {
                "name": "WANG Wei",
                "org": ""
            },
            {
                "name": "QI Guo-xian",
                "org": "//Teaching and Research Office for Geriatric Disease,Department of Cadres Medical Work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "LI Ting-fu",
                "org": "//Teaching and Research Office for Geriatric Disease,Department of Cadres Medical Work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "TIAN Shu-xu",
                "org": ""
            },
            {
                "name": "YANG Hong-yan",
                "org": "//Teaching and Research Office for Geriatric Disease,Department of Cadres Medical Work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "ZHU He",
                "org": "//Teaching and Research Office for Geriatric Disease,Department of Cadres Medical Work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "WU Peng-li",
                "org": "//Teaching and Research Office for Geriatric Disease,Department of Cadres Medical Work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "WANG Tong-cai",
                "org": "//Teaching and Research Office for Geriatric Disease,Department of Cadres Medical Work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "CHEN Jie",
                "org": "//Teaching and Research Office for Geriatric Disease,Department of Cadres Medical Work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            }
        ],
        "venue": "Chinese Journal of Cardiovascular Rehabilitation Medicine",
        "year": 2012
    },
    "fghJ3CGd": {
        "id": "fghJ3CGd",
        "title": "Analysis of relative risk factors for diabetic nephropathy",
        "abstract": "Objective:To study relative risk factors for diabetic nephropathy(DN).Methods:A total of 238 patients diagnosed as type 2 diabetes mellitus(DM) were enrolled in the study.According to urine microalbuminuria to urine creatinine ratio(UACR),patients were divided into pure DM group(group DM1,n=90),early diabetic nephropathy group(group DM2,n=73) and clinical diabetic nephropathy group(group DM3,n=75).Clinic data of all patients were collected;Fasting blood glucose(FBG),2h postprandial blood glucose(2hPB),blood lipids,uric acid(UA),fibrinogen(Fg) and glycosylated haemoglobin(HbA1c) were measured in all patients,and their correlations with DN were analyzed.Results:Compared with group DM1,the course of disease in DM [(7.25\u00b16.29) years vs.(10.25\u00b17.67) years vs.(13.53\u00b17.82) years],levels of FBG [(8.46\u00b12.52) mmol/L vs.(9.52\u00b13.38) mmol/L vs.(10.82\u00b13.30) mmol/L],2hPB [(18.40\u00b15.64) mmol/L vs.(20.27\u00b15.94) mmol/L vs.(22.59\u00b16.14) mmol/L],HbA1c [(7.96\u00b11.65)% vs.(8.60\u00b11.76)% vs.(9.55\u00b12.09)%],triglyceride,Fg [(3.49\u00b10.93) g/L vs.(3.88\u00b11.21) g/L vs.(4.99\u00b12.10) g/L]and UA [(295.42\u00b152.34) \u03bcmol/L vs.(324.18\u00b196.29) \u03bcmol/L vs.(351.23\u00b156.88) \u03bcmol/L]significantly increased in group DM2 and group DM3 in order(P<0.01~<0.001).Logistic gradual regression analysis indicated that course of DM,HbA1c,TG,Fg and UA were risk factors for DN(OR=1.008~1.910,P<0.01~<0.001).Conclusion:The course of DM,blood glucose,blood lipid,uric acid and fibrinogen are risk factors for diabetic nephropathy;increased UACR reflects progress of patients\u2032 condition in DM patients,its detection is used for diabetic prognosis and treatment.",
        "keywords": [
            "Albuminuria",
            "Risk factors",
            "Diabetic nephropathies"
        ],
        "authors": [
            {
                "name": "XU Jin-chun",
                "org": "//1.Teaching and Research Office for Geriatric Disease,Department of Cadres Medical Work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "CHEN Si-jiao",
                "org": "//1.Teaching and Research Office for Geriatric Disease,Department of Cadres Medical Work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "ZHANG HAO",
                "org": "Physical Examination Center of the First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "QI Guo-xian",
                "org": "//1.Teaching and Research Office for Geriatric Disease,Department of Cadres Medical Work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "LI Ting-fu",
                "org": "//1.Teaching and Research Office for Geriatric Disease,Department of Cadres Medical Work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "CHEN Jie",
                "org": "//1.Teaching and Research Office for Geriatric Disease,Department of Cadres Medical Work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "GAO Yang",
                "org": "//1.Teaching and Research Office for Geriatric Disease,Department of Cadres Medical Work,First Affiliated Hospital of China Medical University,Shenyang,Liaoning,,China"
            },
            {
                "name": "SONG Jin-dan",
                "org": " Medical Molecular Biology Research Institute of China Medical University,Key Laboratory of Cell Biology of Ministry of Health,Shenyang,Liaoning,,China"
            }
        ],
        "venue": "Chinese Journal of Cardiovascular Rehabilitation Medicine",
        "year": 2012
    },
    "Rr4u18aR": {
        "id": "Rr4u18aR",
        "title": "Effects of RNA interference on epidermal growth factor receptor expression in SPC-A-1 cells]",
        "abstract": "To investigate whether RNA interference (RNAi) induced by small interference RNA (siRNA) could suppress epidermal growth factor receptor (EGFR) expression in non-small-cell lung carcinoma (NSCLC) cells.SPC-A-1 cells were transfected using chemically synthesized double stranded RNA (dsRNA) formulated with Lipofectamine 2000. The EGFR numbers were determined by both Western blot and flow cytometry. The antiproliferative effects of dsRNA-EGFR were assessed using cell counts and colony assay. Cell cycle analysis was carried out via flow cytometry. The chemosensitivity of transfected cells to cisplatin was determined by MTT.Sequence specific siRNAs targeting EGFR down-regulated EGFR expression significantly. Compared with the control group, dsRNA-EGFR reduced the cell numbers by 78.3% and decreased the colonies by 66.8%. Cell cycle analysis showed that dsRNA-EGFR induced accumulation of cells in G0-G1 phase by 17.48% with a significant decrease in the percentage of cells in S-phase by 19.20% relative to the control. Based on the value of IC50 obtained by Origin 6.0 software, we concluded that dsRNA-EGFR increased the sensitivity of SPC-A-1 to cisplatin by seven-fold.Sequence specific siRNAs targeting EGFR was capable of suppressing EGFR expression, and therefore, significantly inhibiting cellular proliferation and inducing cell cycle arrest. The finding from chemosensitivity assay further revealed that dsRNA-EGFR was associated with an addictive or synergistic effect on tumor growth inhibition when combined with cisplatin. The successful application of dsRNA-EGFR for inhibition of proliferation in EGFR overexpressing cells extends the list of available therapeutic modalities in the treatment of human cancer.",
        "keywords": [
            "cx"
        ],
        "authors": [
            {
                "name": "Min Zhang",
                "org": "Institute of Respiratory Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China."
            },
            {
                "name": "Xin Zhang",
                "org": ""
            },
            {
                "name": "Chun-xue Bai",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "MinQ Wei",
                "org": ""
            }
        ],
        "venue": "Zhonghua nei ke za zhi",
        "year": 2004
    },
    "4PSge9lU": {
        "id": "4PSge9lU",
        "title": "Effect of RNA interference on EGF receptor expression of non-small-cell lung cancer A549 cell line]",
        "abstract": "To investigate changes in biologic properties of non-small-cell lung cancer (NSCLC) A549 cells whose EGF receptor (EGFR) expression was suppressed by short interference RNA (siRNA).A549 cells were transfected with synthetic EGFR sequence-specific siRNA by Lipofectamine. EGFR expression was examined by Western blot and flow cytometry. The biological features of the transfected A549 cells were assessed by cell cycle analysis, colony formation and chemosensitivity assay.Sequence-specific siRNAs targeting EGFR significantly down-regulated its expression in A549 cells. Cell growth and colony formation were inhibited by 85.0% and 63.3%, respectively, as compared to the non-sequence-specific siRNA treated cells. Decreased EGFR expression was accompanied by 12.7% increase in A549 cells in G(0)-G(1) phase and 6.6% decrease in S-phase. The EGFR sequence-specific siRNA transfected A549 cells were much more sensitive to the cytotoxic effect of cisplatin with a 77.2% decrease in IC(50) compared to the non-sequence-specific iRNA transfected A540 cells.Down regulation of EGFR expression of NSCLC by sequence-specific siRNA may be considered as an additional option in the treatment of EGFR over-expressing cancers, including NSCLC.",
        "keywords": [
            "cx"
        ],
        "authors": [
            {
                "name": "Min Zhang",
                "org": "Department of Pulmonary Disease, Fudan University, Shanghai 200032, China."
            },
            {
                "name": "Xin Zhang",
                "org": ""
            },
            {
                "name": "Chun-xue Bai",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "MinQ Wei",
                "org": ""
            }
        ],
        "venue": "Zhonghua zhong liu za zhi [Chinese journal of oncology]",
        "year": 2004
    },
    "TfLAup9M": {
        "id": "TfLAup9M",
        "title": "The Establishment of GFP Stably Expressing Cell Line Using Replication Incompetent Lentiviral Vectors",
        "abstract": "Objectives:To establish a green fluorescent protein (GFP) stably expressing cell line using replication incompetent lentiviral vector. Methods: Vector plasmid pHR'-pCMV-GFP containing GFP gene as a target gene, package construct pCMV- \u0394R8.2 and an envelope plasmid pCMV-VSVG were co-transfected into 293T packaging cell line using Ca-P precipitation method. The viruses harvested from the supernatant were used to transfect 293T cells again. Then the GFP strongly expressing monoclone was selected with a clone ring and then passaged. After 12 passages, the cells were sent for FACS to convince the stability of the GFP expression. Besides, a GFP targeted RNA interference experiment was conducted to assure that this cell line could be used in gene expression regulation experiments. Results: A GFP stably expressing cell line G4 was established, in this cell line more than 99% of the cells expressed GFP, which was stable after at least 12 passages and could be efficiently downregulated by RNAi. Conclusion: These researches showed that the lentiviral vector was efficient to establish GFP expressing cell lines, and using this vector a GFP stably expressing cell line G4 was established, which could be used efficiently in gene regulation research.",
        "keywords": [
            "Green fluorescent protein",
            "Lentiviral vector",
            "Cell line"
        ],
        "authors": [
            {
                "name": "ZHOU Lei",
                "org": " Department of Pulmonary Diseases, Zhongshan Hospital, Fudan University, Shanghai "
            },
            {
                "name": "CHEN Jie",
                "org": " Department of Pulmonary Diseases, Zhongshan Hospital, Fudan University, Shanghai "
            },
            {
                "name": "XU Xin",
                "org": " Department of Pulmonary Diseases, Zhongshan Hospital, Fudan University, Shanghai "
            },
            {
                "name": "ZHANG Min",
                "org": " Department of Pulmonary Diseases, Zhongshan Hospital, Fudan University, Shanghai "
            },
            {
                "name": "ZHANG Xin",
                "org": " Department of Pulmonary Diseases, Zhongshan Hospital, Fudan University, Shanghai "
            }
        ],
        "venue": "Chinese Journal of Clinical Medicine",
        "year": 2009
    },
    "e7SL8Xlh": {
        "id": "e7SL8Xlh",
        "title": "Antitumor effect of epidermal growth factor receptor gene silencing]",
        "abstract": "To investigate whether chemically synthesized double-stranded RNA (dsRNA) targeting epidermal growth factor receptor (EGFR) could induce gene silencing in non-small-cell lung cancer (NSCLC) cells, and to assess the degree of EGFR gene silencing and its effect on functional outcome.NSCLC cell line SPC-A-1 was transfected with target sequence-specific dsRNA formulated with Lipofectamine 2000. Fluorescent microscopy and flow cytometry were used to measure the reduction in the production of the EGFR protein. Real-time PCR was used to detect the silencing of the EGFR gene level. Colony assay was adopted to measure the cellular proliferation and colony formation. A tumor burdened athymic nude mouse model was established to calculate the tumor growth inhibition rate.The dsRNA-EGFR was shown to be effective with a 71.3% down-regulation of EGFR protein production and 50.0% of silencing of EGFR gene. The dsRNA-EGFR significantly reduced colony numbers by 66.8% in vitro and inhibited the tumor growth in vivo. The tumor growth inhibition rate was 75.0%.The sequence specific dsRNA showed a blockbuster effect in downregulation of EGFR gene level and protein production, inhibition of the cellular proliferation and tumor growth.",
        "keywords": [
            "growth inhibition rate",
            "receptor",
            "non-small-cell lung",
            "rna",
            "double-stranded",
            "cancer",
            "epidermal growth factor"
        ],
        "authors": [
            {
                "name": "Min Zhang",
                "org": "Department of Respirtory Medicine-Institute of Respirtory Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China."
            },
            {
                "name": "Chun-xue Bai",
                "org": ""
            },
            {
                "name": "Xin Zhang",
                "org": ""
            },
            {
                "name": "Lei Gao",
                "org": ""
            },
            {
                "name": "Ling Mao",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            }
        ],
        "venue": "Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases",
        "year": 2005
    },
    "Ee9gEJp2": {
        "id": "Ee9gEJp2",
        "title": "Downregulation enhanced green fluorescence protein gene expression by RNA interference in mammalian cells.",
        "abstract": "RNA interference (RNAi) is a recently observed process by which double-stranded RNA (dsRNA) directs sequence-specific degradation of messenger RNA (mRNA) in animal and plant cells. In several model systems, RNAi had been developed into a useful tool for the investigation of gene function. In order to study the effectiveness of RNAi in mammalian cells, we introduced chemically synthetic 21-nucleotide small interference RNA (siRNA) duplexes into 293T/GFP cells, which were transduced by enhanced green fluorescence protein (EGFP) gene, by means of TransIT-TKO, Oligofectamine reagent, Lipofectamine 2000 respectively. The results demonstrated that EGFP expression was significantly and specifically inhibited by the corresponding dsRNA, but not by unrelated dsRNA. In three different vectors, Lipofectamine 2000 demonstrated the highest transfection efficiency with a 48 h exposure. The decrease in EGFP fluorescence intensity was approximately 80%. Although TransIT-TKO and Oligofectamine displayed similar trends, the transfections were inefficient, and often toxic. The results also exhibited that siRNA inhibited the EGFP gene expression in a dose and time-dependent manner. Therefore, we concluded that the Lipofectamine 2000 was a better transfection reagent for RNAi. RNAi pathway seems operative in mammalian embryo cells. RNAi may be developed into a potential tool for gene therapy.",
        "keywords": [],
        "authors": [
            {
                "name": "Min Zhang",
                "org": "Department of Pulmonary Diseases, Zhongshan Hospital, Fudan University, Shanghai, China."
            },
            {
                "name": "Chun-Xue Bai",
                "org": ""
            },
            {
                "name": "Xin Zhang",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Ling Mao",
                "org": ""
            },
            {
                "name": "Lei Gao",
                "org": ""
            }
        ],
        "venue": "RNA biology",
        "year": 2004
    },
    "COxad3dw": {
        "id": "COxad3dw",
        "title": "Determination of 24 Allergens in Suspicious Cosmetics by Gas Chromatography-Mass Spectrometry",
        "abstract": "A simultaneous determination method was developed for the reliable screening,quantification and confirmation of 24 allergens in cosmetics by gas chromatography-mass spectrometry(GC-MS).The 24 allergens were extracted from cosmetics with methanol,then determined by GC-MS with the external standard method under the selected ion mode(SIM).The calibration curves showed good linearities in the range of 0.2-100 mg/L with correlative coefficients(r2) larger than 0.995.The detection limits were in the range of 2-10 mg/kg,and the average recoveries were 80%-104% with relative standard deviations of 1.8%-9.3%.The method was rapid,accurate and sensitive.The positive detection rate of 24 allergens in 150 samples of 77 patients using cosmetics was 78%,and there was at least one allergen measured value above 10 mg/kg in 81.2% of the positive samples.24 allergens in the cosmetics used by 71 patients were detected out and the detection rate was 92.2%,which at least one allergen measured value above 10 mg/kg was 90.1%.24 allergens are the major allergens in cosmetic contact dermatitis.",
        "keywords": [
            "allergen",
            "contact dermatitis",
            "gas chromatography-mass spectrometry",
            "cosmetics"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Guangzhou Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "JIAO Hong",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            },
            {
                "name": "YE Hong-yi",
                "org": "Guangzhou Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "BI Ying-jie",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            },
            {
                "name": "LIU Chao",
                "org": "Guangzhou Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "ZHENG Xuan",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            },
            {
                "name": "ZHAN Jing",
                "org": "School of Public Health,Sun Yat-sen University, Guangzhou ,China"
            },
            {
                "name": "LAI Wei",
                "org": "The Third Affiliated Hospital,Sun Yat-sen University,Guangzhou ,China"
            }
        ],
        "venue": "Journal of Instrumental Analysis",
        "year": 2012
    },
    "oLmiWaet": {
        "id": "oLmiWaet",
        "title": "Liquid Chromatography-Tandem Mass Spectrometric Determination of Metalaxyl Residue in Animal-derived and Plant-derived Foods",
        "abstract": "An analytical method using liquid chromatography-tandem mass spectrometry (LC-MS/MS) was presented for the determination of metalaxyl residue in 2 animal-derived foods,namely pigeon meat and duck kidney and 6 plant-derived foods,namely multiple vegetable juice,apple,sweet orange,grape,lemon and kiwifruit.The analyte was quantified by the external standard method.Mean spike recoveries of metalaxyl ranged from 95.9% to 102.0% for animal-derived foods (represented by duck kidney),and 116.4% and 141.0% for plant-derived foods (represented by sweet orange),with relative standard deviations ranging from 2.13% to 12.7% for duck kidney and from 0.37% to 4.09% for sweet orange.The limits of detection of the method for duck kidney and apple were 0.002 mg/kg and 0.001 mg/kg,respectively.",
        "keywords": [
            "metalaxyl",
            "pesticide residue",
            "food",
            "liquid chromatography-tandem mass spectrometry (LC-MS/MS)"
        ],
        "authors": [
            {
                "name": "XU Juan",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "LIN Feng",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "WANG Lan",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "SHAO Lin-zhi",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "WU Ying-xuan",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "JIAO Hong",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            }
        ],
        "venue": "Food Science",
        "year": 2010
    },
    "TtgeLUcD": {
        "id": "TtgeLUcD",
        "title": "Determination of 19 Pesticide Residues in Tea Using QuEChERS Extraction and High-performance Liquid Chromatography-Electrospray Tandem Mass Spectrometry",
        "abstract": "A multiresidue method was developed for the simutaneous determination of 19 pesticides in tea by LC-MS/MS.The ionisation mode used was positive mode with multiple reaction monitoring.The one precursor/two product ion transitions were used for each neonicotinoids.The procedure,based on QuEChERS prior to the determination by UPLC-MS/MS,was validated based on the SANCO European Guidelines with satisfactory spiked recovery(68%\u2013105%) and measurement uncertainty(\u226420%).The results showed that the calibration curves were linear in the range of 1-15 \u03bcg/L for 18 analytes and 5-75 \u03bcg/L for difulubenzuron.The limits of quantitation(LOQ) were 50 \u03bcg\u00b7kg-1 for difulubenzuron and 10 \u03bcg\u00b7kg-1 for the other 18 pesticides.The method was simple,rapid and accurate,and could meet the requirement of the maximum residue limits(MRLs) for pesticides in tea as recommended by the European Union.",
        "keywords": [
            "QuEChERS",
            "LC-MS/MS",
            "tea",
            "multiresidue analysis"
        ],
        "authors": [
            {
                "name": "XU Juan",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            },
            {
                "name": "YE Hong-yi",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            },
            {
                "name": "WANG Lan",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            },
            {
                "name": "SUN Ling-hui",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            },
            {
                "name": "LAI Zi-feng",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            }
        ],
        "venue": "Journal of Instrumental Analysis",
        "year": 2011
    },
    "EZr8ZGYY": {
        "id": "EZr8ZGYY",
        "title": "Determination of Chlordimeform and Its Metabolite 4-Chloro-2-methylaniline Residues in Animal Derived Foods by Gas Chromatography-Mass Spectrometry",
        "abstract": "A method was established for the determination of chlordimeform and its metabolite 4-chloro-2-methylaniline residues in foods of animal by GC-MS.Five kinds of foods derived from animal(e.g.tilapia muscle,chicken liver,pork,shrimp and beef) were extracted with ethyl acetate in alkaline conditions(pH\u226511.0).The extracts were purified with the graphitization carbon black cartridge(GCB SPE,250 mg/3 mL) and neutral alumina solid phase cartridge(Al2O3 SPE,2.0 g/3 mL),and then determined by GC-MS.Good linear relationships were obtained between the peak areas and the concentrations of chlordimeform and its metabolite 4-chloro-2-methylaniline within the range of 10-500 \u03bcg/L,with correlation coefficients of 0.999 1 and 0.998 7,respectively.The recoveries were in the ranges of 81%-119% for chlordimeform,and 80%-119% for 4-chloro-2-methylaniline,with RSDs(n=6) of 1.1%-11.7% and 2.0%-13.7%,respectively.The results showed that the quantitation limits for the two compounds were both 10.0 \u03bcg/kg.The proposed method was accurate,sensitive and high-efficient,and was applicable in the determination of chlordimeform and its metabolite in animal derived foods.",
        "keywords": [
            "animal derived foods",
            "4-chloro-2-methylaniline",
            "chlordimeform",
            "gas chromatography mass spectrometry(GC-MS)"
        ],
        "authors": [
            {
                "name": "XIE Jian-jun",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            },
            {
                "name": "HE Man-li",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            },
            {
                "name": "YUAN Zhen-yu",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            },
            {
                "name": "SUN Ling-hui",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            }
        ],
        "venue": "Journal of Instrumental Analysis",
        "year": 2012
    },
    "Nd8iVnuZ": {
        "id": "Nd8iVnuZ",
        "title": "Determination of endosulfan residues in eel using GC]",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Jianjun Xie",
                "org": "jianjunxie@tom.com"
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Hong Jiao",
                "org": ""
            },
            {
                "name": "Liuming Zhu",
                "org": ""
            }
        ],
        "venue": "Se pu = Chinese journal of chromatography / Zhongguo hua xue hui",
        "year": 2007
    },
    "jYj80zJy": {
        "id": "jYj80zJy",
        "title": "Determination of 287 pesticide residues in vegetable by gas chromatography-tandem mass sepctometry with multiple reaction monitoring and production scan",
        "abstract": "A simple method for the determination of 287 pesticide residues in vegetable by gas chromatography-triple quadrupole tandem mass spectrometry(GC-MS/MS) was established.The vegetable sample was pretreated in a single extraction,based on a modified \"QuEChERS method\",and further purified on the chlorophyll innovation,by changing the polarity of the system,so that the solubility of chlorophyll in acetonitrilewater system was reduced and precipitated,and then filtered by 0.2 \u03bcm organic membrane phase,leading to effective removal of chlorophyll.Limits of detection obtained were lower than 10 \u03bcg/kg and pesticide recoveries spiked with 10,20 and 100 \u03bcg/kg yielded average recoveries in the range between 60% and 110% for 277 analytes.The proposed method featured good precision,expressed as relative standard deviation was less than 20%.Besides the evaluation of the sample preparation approaches,we also discuss the use of advanced software features associated to MRM method development that overcome several limitations and drawbacks associated to MS/MS methods(time scheduled and acquisition limitations).The identification and confirmation of the compounds were based on retention time matching along with the presence(and ratio) of two typical MRM transitions.Product ion scan could be obtained synchronized under the limit of quantification less than 10 \u03bcg/kg residual concentration.The proposed method was applied successfully to the residue determination of the selected pesticides in commercial vegetable samples.",
        "keywords": [
            "Vegetable",
            "Product ion scan",
            "Multiresidue analysis",
            "T-SRM",
            "Gas chromatography-triple quadrupole tandem mass spectrometry"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Ghuangzhou "
            },
            {
                "name": "XU Juan",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Ghuangzhou "
            },
            {
                "name": "XIE Jian-jun",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Ghuangzhou "
            },
            {
                "name": "YUAN Zhen-yu",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Ghuangzhou "
            },
            {
                "name": "LIU Chao",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Ghuangzhou "
            }
        ],
        "venue": "Chinese Journal of Analysis Laboratory",
        "year": 2013
    },
    "QyzlQsKu": {
        "id": "QyzlQsKu",
        "title": "Study on the determination of flonicamid residues in plant-based foods by gas chromatography",
        "abstract": "\u3010Objective\u3011 The study was to establish a rapid method to determine flonicamid residues in seven kinds of plant-based foods by gas chromatography.\u3010Method\u3011 In this method,experiments on the extraction solvents,gathering time by GPC,solid phase extraction cartridges and columns of GC were carried out.And,a rapid method to determine flonicamid residues in plant-based foods by gas chromatography was established.The detection range and the limit of low detection of the method were also studied,while the recoveries and the precision of flonicamid were analyzed too.\u3010Result\u3011 The established method to determine flonicamid residues in plant-based foods by gas chromatography demonstrated that the samples were homogenized and extracted with ethyl acetate,and extracts were loaded into GPC(gathering time 7-14 min).Eluent was cleaned up with NH2 SPE cartridge.The final purified extract of food was analyzed by GC with DB-1701.The result showed that the limit of low detection was 10 \u03bcg/L.There was a good linear relationship between the peak area value and the concentration of flonicamid within range of 10-500 \u03bcg/L(correlation coefficient=0.999).When the spiked concentration of flonicamid was 10,20,100,400 \u03bcg/kg respectively,the recoveries ranged from 82.0%-116.0%.The standard deviations ranged from 0.06-3.17 with a high precision.\u3010Conclusion\u3011 This method is simple,inexpensive,accurate and sensitive.",
        "keywords": [
            "GC",
            "flonicamid",
            "plant-based foods"
        ],
        "authors": [
            {
                "name": "XIE Jian-jun",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou,Guangdong ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou,Guangdong ,China"
            },
            {
                "name": "WANG Lan",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou,Guangdong ,China"
            },
            {
                "name": "JIAO Hong",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou,Guangdong ,China"
            },
            {
                "name": "YE Hong-yi",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou,Guangdong ,China"
            },
            {
                "name": "LAI Zi-feng",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou,Guangdong ,China"
            }
        ],
        "venue": "Journal of Northwest A & F University(Natural Science Edition)",
        "year": 2011
    },
    "i8Lno4pq": {
        "id": "i8Lno4pq",
        "title": "Determination of Tiadinil Residues in Foodstuffs of Animal Origin by High Performance Liquid Chromatography-Tandem Mass Spectrometry",
        "abstract": "A high performance liquid chromatography-tandem mass spectrometric(HPLC-MS/MS) method was established to analyse tiadinil residues in foodstuffs of animal origin.Samples were extracted with ethyl acetate using homogenate extraction technology.The supernatant was cleaned up by freezing lipid filtration and gel permeation chromatography(GPC),respectively.Then the extract was further cleaned up on a NH2(aminopropyl) solid phase extraction(SPE) cartridge,condensed to nearly dryness at 45 \u2103 water bath,and redissolved with methanol and deionized water.The identification of tiadinil were carried out by MS/MS equipped with electrospray ionization(ESI) in negative scan and multiple reaction monitoring(MRM) mode.The quantification of tiadinil was performed by external standard method.The result indicated that limit of quantification(LOQ) was 10 \u03bcg/kg,and a good linearity between the peak area and concentration was obtained in the range of 10.0-100.0 \u03bcg/L.The recoveries of tiadinil from chicken,tilapia,beef and sheep liver sample at three spiked concentration levels of 10,20,50 \u03bcg/kg were in the range of 68%-110% with RSDs of 3.2%-15.2%.The method could meet the requirement for determination of tiadinil residues in foodstuffs of animal origin.",
        "keywords": [
            "residues",
            "foodstuffs of animal origin",
            "tiadinil",
            "GPC",
            "HPLC-MS/MS"
        ],
        "authors": [
            {
                "name": "WANG Lan",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "XU Juan",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "XIE Jian-jun",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            }
        ],
        "venue": "Journal of Instrumental Analysis",
        "year": 2010
    },
    "pHBbFbNV": {
        "id": "pHBbFbNV",
        "title": "Determination of 20 kinds of fungicide residues in vegetables and fruits by gas chromatography-mass spectrometry combined modified QuEChERS method",
        "abstract": "Objective To develop a QuEChERS method combined with gas chromatography mass spectrometry (GC/MS) for the determination of 20 kinds of fungicide residues (tricyclazole, quintozene, pyrimethanil, vinclozolin, chlorothalonil, triadimefon, penconazole, procymidone, triadimenol, paclobutrazol, isoprothiolane, imazalil, fludioxonil, flusilazole, myclobutanil, trifloxystrobin, propiconazol, prochloraz, fenbuconazole and difenoconazole) in vegetables and fruits. Methods Twenty kinds of fungicides residues were extracted from the samples (lettuce, hairy squash, grape and plum) with acetonitrile, and then detected by GC/MS with external standard method after being cleaned up with three sorbents (PSA 50.0 mg, Al2O3 50.0 mg and NH2 30.0 mg). Results The method showed a good linearity over the range of 0.025~0.250 mg/L with correlation coefficients of 0.9974~1.0000. The recoveries of fungicides, except Chlorothalonil, were in the range of 83%~112% with the spiked levels of 0.05, 0.1 and 0.2 mg/kg into four vegetables and fruits matrixes, and the relative standard deviations (RSDs) were almost not more than 11.0%. The limits of detections (LODs) were in the range of 0.2~11.8 \u03bcg/kg, respectively. Conclusion The method is sensitive, rapid and simple, and can be used for the determination of 20 kinds of fungicides residues in vegetables and fruits.",
        "keywords": [
            "residue detection",
            "quechers",
            "gas chromatography-mass spectrometry",
            "fungicides",
            "analytical methods",
            "gc ms",
            "food contamination"
        ],
        "authors": [
            {
                "name": "XIE Jian-Jun",
                "org": " Guangdong Entry-Exit Inspection and Quarantine Bureau, Guangzhou , China"
            },
            {
                "name": "CHEN Jie",
                "org": " Guangdong Entry-Exit Inspection and Quarantine Bureau, Guangzhou , China"
            },
            {
                "name": "LI Ju",
                "org": " Dongguan Entry-Exit Inspection and Quarantine Bureau, Dongguan , China"
            },
            {
                "name": "YUAN Zhen-Yu",
                "org": " Guangdong Entry-Exit Inspection and Quarantine Bureau, Guangzhou , China"
            },
            {
                "name": "XIE Yu-Shan",
                "org": " Guangdong Entry-Exit Inspection and Quarantine Bureau, Guangzhou , China"
            }
        ],
        "venue": "Journal of Food Safety & Quality",
        "year": 2013
    },
    "0ZnibJC4": {
        "id": "0ZnibJC4",
        "title": "Determination and confirmation of flonicamid residue in five kinds of animal-derived foods by GC and LC/MS-MS",
        "abstract": "Objective:To establish a method for determination and confirmation of flonicamid residue in five kinds of animal-derived foods by gas chromatography(GC) and liquid chromatography mass-mass spectrometry(LC/MS-MS).Methods: The samples of meat and aquatic products were extracted by ethyl acetate,then the extract was cleaned up by gel permeation chromatography(GPC) and NH2SPE cartridge,while honey was cleaned up by CHROMABOND XTR and NH2SPE cartridges.The concentration of flonicamid residue was analyzed by GC with ECD and confirmed by LC/MS-MS with EI.Results: For GC-ECD,there was a good linear relationship between the peak area and the concentration of flonicamid within range of 10 \u03bcg/kg to 500 \u03bcg/kg(correlation coefficient \u2265 0.999).When the spiked level of flonicamid ranged from 10 \u03bcg/kg to 200 \u03bcg/kg,the mean recoveries of the method varied from 74.5% to 98.2% and the relative standard deviations(RSD) ranged from 1.02% to 7.98%.The results showed that the limit of detection(LOD) was 1.0 \u03bcg/kg and the limit of quantification(LOQ) was 5.0 \u03bcg/kg.The flonicamid was confirmed by LC/MS-MS and the limit of detection was 5.0 \u03bcg/kg.Conclusion: The method was simple,fast and accurate.",
        "keywords": [
            "LC/MS-MS",
            "GC",
            "Animal-derived foods",
            "Flonicamid",
            "Residue analysis"
        ],
        "authors": [
            {
                "name": "XIE Jian-jun",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau Technology Center,Guangzhou ,China"
            },
            {
                "name": "WANG Lan",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau Technology Center,Guangzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau Technology Center,Guangzhou ,China"
            },
            {
                "name": "LIN Hai-dan",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau Technology Center,Guangzhou ,China"
            },
            {
                "name": "WU Ying-xuan",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau Technology Center,Guangzhou ,China"
            },
            {
                "name": "XU Juan",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau Technology Center,Guangzhou ,China"
            },
            {
                "name": "YE Hong-yi",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau Technology Center,Guangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Health Laboratory Technology",
        "year": 2011
    },
    "GbRrwhQ2": {
        "id": "GbRrwhQ2",
        "title": "Large-scale Analysis of Pesticides in Fruits and Vegetables by Liquid Chromatography-Electrospray Tandem Mass Spectrometry with QuEChERS as Cleanup Step",
        "abstract": "A multi residue analysis was developed for the determination of 230 pesticides,which belonged to different chemical classes,in fruits and vegetables.The sample was prepared by the modified QuEChERS method.The detection of 230 pesticides was performed by liquid chromatography-tandem mass spectrometry(LC-MS/MS) with the external standard method.The calibration curves of target compounds were linear in the range of 0-15 \u03bcg/L with correlation coefficients more than 0.996.The limits of quantitation were lower than 1.0 \u03bcg/kg for 80% analytes.The recoveries at spiked levels of 5,10 and 20 \u03bcg/kg were in the range of 60%-120% with RSD less than 20%.An advanced software features associated with MRM method development(S-MRM) was adopted.The proposed method was applied successfully in the residue determination of multi-pesticides in commercial fruits and vegetables samples with its advantages of simiplicity and stableness.",
        "keywords": [
            "fruits and vegetable",
            "QuEChERS",
            "LC-MS/MS",
            "scheduled multiple reaction monitoring(S-MRM) mode",
            "multiresidue analysis"
        ],
        "authors": [
            {
                "name": "XU Juan",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            },
            {
                "name": "WANG Lan",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            },
            {
                "name": "SUN Ling-hui",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            },
            {
                "name": "YUAN Zhen-yu",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            },
            {
                "name": "YE Hong-yi",
                "org": "Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            },
            {
                "name": "ZHU Lin",
                "org": "AB SCIEX Asia Pacific Application Support Center,Shanghai ,China"
            }
        ],
        "venue": "Journal of Instrumental Analysis",
        "year": 2013
    },
    "bgzPoWkO": {
        "id": "bgzPoWkO",
        "title": "Design Flattening Filter of Medical Accelerator Using Monte Carlo Method",
        "abstract": "Using BEAMnrc to model the beam geometry of medical linear accelerator treatment head,X-ray dose distribution for a field sized 10 cm\u00d710 cm is calculated after the X-ray passed through a flattening filter consisting of single material or multi-material.By comparing the results of the off-axial ratio(OAR),the off-axis dose distribution and off-axis energy fluence distribution curves under GB 15213\u201494,a multi-material flattening filter with better flatness is designed.Angular distribution of particles,X-ray dose rate and charged particles pollution are discussed.The results show that this flattening filter has advantages including good flatness,satisfactory forward shooting property of particles,and low pollution of charged particles.",
        "keywords": [
            "flattening filters",
            "off-axial ratio(OAR)",
            "BEAMnrc",
            "phase space files",
            "percentage depth dose(PDD)"
        ],
        "authors": [
            {
                "name": "PAN Fu-xing",
                "org": "Shanghai Applied Radiation Institute,Shanghai University,Shanghai ,China"
            },
            {
                "name": "LUO Wen-yun",
                "org": "Shanghai Applied Radiation Institute,Shanghai University,Shanghai ,China"
            },
            {
                "name": "ZHOU Shi-qing",
                "org": "Shanghai Applied Radiation Institute,Shanghai University,Shanghai ,China"
            },
            {
                "name": "DONG Xiao-qing",
                "org": "Shanghai Applied Radiation Institute,Shanghai University,Shanghai ,China"
            },
            {
                "name": "WANG Chuan-shan",
                "org": "Shanghai Applied Radiation Institute,Shanghai University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Shanghai Applied Radiation Institute,Shanghai University,Shanghai ,China"
            },
            {
                "name": "WU Guo-hua",
                "org": "Department of Radiation Therapy,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai ,China"
            },
            {
                "name": "ZHA Yuan-zi",
                "org": "Department of Radiation Therapy,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai ,China"
            },
            {
                "name": "JIANG Ma-wei",
                "org": "Department of Radiation Therapy,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai ,China"
            }
        ],
        "venue": "Journal of Shanghai University(Natural Science Edition)",
        "year": 2011
    },
    "2cqj0gIZ": {
        "id": "2cqj0gIZ",
        "title": "Radiation Synthesis and Characteristic of Hydrogel  Composed of Poly(vinyl alcohol) and Carboxymethylated Chitosan",
        "abstract": "Hydrogel(PVA/CMCH) from poly(vinyl alcohol)(PVA) and carboxymethylated chitosan(CMCH) was prepared by irradiating the aqueous solution mixture of PVA and CMCH with electron beam.The effects of feed ratio of PVA and CMCH,the radiation dose,temperature and pH on the swelling ratio of PVA/CMCH were studied.The results indicated that the hydrogel was thermo-and pH-sensitive.In deionized water,the hydrogel had a higher swelling ratio at 5\uff5e20 \u2103,but a lower swelling ratio when the temperature was over 20 \u2103;In pH buffer solution,the hydrogel showed a higher swelling ratio in the conditions of pH<4.0 and pH>6.0,however,the swelling ratio was relatively lower in the range of pH 4.0\uff5e6.0.",
        "keywords": [
            "poly(vinyl alcohol)",
            "pH-sensitivity",
            "thermo-sensitivity",
            "hydrogel",
            "carboxymethylated chitosan"
        ],
        "authors": [
            {
                "name": "WANG Sheng",
                "org": "Department of Chemical Engineering and Technology,School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "YANG Li-ming",
                "org": "Department of Chemical Engineering and Technology,School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Department of Chemical Engineering and Technology,School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "SUN Jie",
                "org": "Department of Chemical Engineering and Technology,School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "LI Zhi-jun",
                "org": "Department of Chemical Engineering and Technology,School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "WANG Tao",
                "org": "Department of Chemical Engineering and Technology,School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            }
        ],
        "venue": "Chemical Research",
        "year": 2006
    },
    "DLM5uN0i": {
        "id": "DLM5uN0i",
        "title": "Chitosan-Poly (acrylic acid) Magnetic Microspheres Prepared by in situ Polymerization Method and their Characterization",
        "abstract": "In order to enhance the bio-safety of the hydrogel magnetic microspheres and avoid staining it with the organic solvent used during its preparation, the chitosan-poly(acrylic acid) (CS-PAAc) magnetic microspheres were prepared by in situ polymerization method in an aqueous system. Chitosan (CS) was coated first on the surface of Fe3O4 nanoparticles, followed by acrylic acid attaching on the CS magnetic microspheres and then polymerizing in situ. The CS-PAAc magnetic microspheres were obtained after crosslinking by glutaraldehyde. The physicochemical properties of prepared CS-PAAc magnetic microspheres were investigated by FT-IR, scanning electron microscope (SEM), thermal gravimetric analysis (TGA), element analysis, vibrating-sample magnetometer (VSM), and laser particle analyzer (LSD). The result shows that the prepared CS-PAAc magnetic microspheres possess a good sphericity with an average diameter of 500 nm and have a superparamagnetic property with the saturation magnetization of 45 emu\u00b7g-1. The quantity of Fe3O4 in the prepared CS-PAAc magnetic microspheres is about 73 %(wt). The effect of pH on swelling ratio of the prepared CS-PAAc magnetic microspheres was studied. It was found that the prepared CS-PAAc magnetic microspheres show good pH-sensitivity; and its smallest swelling ratio is at pH=3.",
        "keywords": [
            "Acrylic acid",
            "Chitosan",
            "Hydrogel",
            "Magnetic microspheres",
            "PH-sensitive"
        ],
        "authors": [
            {
                "name": "JIE Shao-wei",
                "org": "School of Environmental and Chemical Engineering, Shanghai University, Shanghai , China"
            },
            {
                "name": "YANG Li-ming",
                "org": "School of Environmental and Chemical Engineering, Shanghai University, Shanghai , China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Environmental and Chemical Engineering, Shanghai University, Shanghai , China"
            },
            {
                "name": "Ting Shan",
                "org": "Shanghai University(Shanghai University),Shanghai,China"
            },
            {
                "name": "QIAN Qiang",
                "org": "School of Environmental and Chemical Engineering, Shanghai University, Shanghai , China"
            }
        ],
        "venue": "Journal of Chemical Engineering of Chinese Universities",
        "year": 2008
    },
    "WEI8jQ3h": {
        "id": "WEI8jQ3h",
        "title": "Study on the Treatment of High Strength Ammonia Wastewater by Using Inner Circulation Impinging Stream Biofilm Reactor",
        "abstract": "[Objective] The treatment effect of inner circulation impinging stream biofilm reactor(ICISBR) on high strength ammonia wastewater was studied.[Method] By means of ICISBR,high strength ammonia wastewater was treated by using corncob as biological carrier,and the effect of C/N and dissolved oxygen(DO) on the removal effect of chemical oxygen demand(COD) and ammonia nitrogen(NH+4-N) were discussed in our paper.[Result] When NH+4-N and DO in effluent water were 200 and 2 mg/L,respectively,the removal effect of COD was not affected obviously whether C/N was 1.0 or 1.5,reaching above 92%;when C/N was 1.5,the average removal rate of COD and NH+4-N were the highest,namely 92.7% and 41.2%,respectively;when C/N was 2.0,the average removal rate of COD and NH+4-N decreased obviously to 20% and 10%;when C/N and NH+4-N were 1.5 and 200 mg/L,DO had little effects on the removal of COD and great effects on the removal of NH+4-N,namely the removal rate of NH+4-N decreased to 17.1% from 46.4% with the reduction of DO concentration from 4 to 1 mg/L.[Conclusion] Our study could provide theoretical basis for the treatment of high strength ammonia wastewater.",
        "keywords": [
            "Ammonia nitrogen wastewater",
            "C/N",
            "ICISBR",
            "China",
            "Corncob"
        ],
        "authors": [
            {
                "name": "LI Guo-chao",
                "org": "College of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China;College of Chemistry and Chemical Engineering,Jiujiang University,Jiujiang ,China"
            },
            {
                "name": "YANG Tao",
                "org": "College of Chemistry and Chemical Engineering,Jiujiang University,Jiujiang ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "ZHANG Xin-hua",
                "org": "College of Chemistry and Chemical Engineering,Jiujiang University,Jiujiang ,China"
            }
        ],
        "venue": "\u6c14\u8c61\u4e0e\u73af\u5883\u7814\u7a76(\u82f1\u6587\u7248)",
        "year": 2010
    },
    "uTh4KcdN": {
        "id": "uTh4KcdN",
        "title": "Interfacial Tension and Foaming Properties of APG and LC Aqueous Solutions with High Salinity in High Temperature",
        "abstract": "For the preparation of a foam flooding system in the presence of high content of salinity at high temperature,alkyl polyglycosides(APG) and 2-Undecyl-N-Carboxymethyl-N-Hydroxyethyl Imidazoline(LC) system was investigated at diferent concentrations and proportions.Foam properties such as interfacial tension(IFT),foamability,and foam stability were measured.Oil-water IFT of the APG-LC system was measured with the spinning drop method on SVT20N at diferent ratios of APG and LC with diferent concentrations,respectively.The results showed that the ratio of APG and LC directly afects IFT of the blend system.When the ratio of APG and LC was 6\u22364 and mass fraction of the blend system was 0.3%,the IFT was minimum.",
        "keywords": [
            "interfacial tension(IFT)",
            "amphoteric surfactant",
            "foam stability",
            "foam flooding system",
            "nonionic surfactant"
        ],
        "authors": [
            {
                "name": "MENG Qing-yang",
                "org": ""
            },
            {
                "name": "CHEN Jie",
                "org": ""
            },
            {
                "name": "ZHAO Tian-jing",
                "org": ""
            },
            {
                "name": "YANG Li-ming",
                "org": ""
            },
            {
                "name": "XU Yi",
                "org": ""
            },
            {
                "name": "XIANG Ming-hui",
                "org": ""
            },
            {
                "name": "ZHU Yang-wen",
                "org": ""
            }
        ],
        "venue": "Journal of Shanghai University(Natural Science)",
        "year": 2013
    },
    "2mYkrzOd": {
        "id": "2mYkrzOd",
        "title": "Intelligent molecular imprinted hydrogel",
        "abstract": "Molecular imprinting technology (MIT) developed rapidly in several decades.The main applications of MIT included separation processes,immunoassays,antibody mimics,biosensors,catalysis and artificial enzymes.However, currently relatively little attention has been paid to hydrogels.This article seeks to introduce a new intelligent-im- printed hydrogel which memorize their binding conformation and can be switched on and off by external stimuli which modify their swelling behavior.Intelligent-imprinted hydrogels chiefly attach biomacromolecules,such as protein, peptide,nucleic acid,glucose,therefore they have art enormous potential in drug deliver system and biosensors,etc.",
        "keywords": [
            "molecular recognition",
            "molecular imprint",
            "intelligent hydrogel"
        ],
        "authors": [
            {
                "name": "Sun Jie",
                "org": "School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "Chen Jie",
                "org": "School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "Zhuang Yun-long",
                "org": "School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            }
        ],
        "venue": "Chemical Sensors",
        "year": 2005
    },
    "hxDvXile": {
        "id": "hxDvXile",
        "title": "Synthesis and Characteristics of Interpenetrating Network Hydrogels of Poly(acrylamide) /Poly-(N-isopropylacrylamide)",
        "abstract": "Interpenetrating polymer network(IPN) hydrogels composed of poly(N-isopropylacrylamide)(PNIPAAm) and poly(acrylamide)(PAAm) were synthesized by sequential IPN method using electron beam.The equilibrium swelling ratios of the hydrogels were investigated under conditions of different pH,temperature and ionic strength.It appeared that the IPN hydrogels exhibited temperature sensitivity,but the phase transition of the IPN hydrogels was not obvious with the increase of acrylamide content,and the phase transition could be controlled by the ratio of PNIPAAm to PAAm.The experimental results also showed that the IPN hydrogels are pH-sensitive,and the IPN hydrogels have the properties of salt resistance compared with pure PNIPAAm hydrogel.",
        "keywords": [
            "pH sensitivity",
            "poly(N-isopropylacrylamide)",
            "temperature sensitivity",
            "hydrogel",
            "electron beam",
            "poly(acrylamide)"
        ],
        "authors": [
            {
                "name": "LI Zhi-jun",
                "org": "Department of Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Department of Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "YANG Li-ming",
                "org": "Department of Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "WANG Tao",
                "org": "Department of Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "WANG Sheng",
                "org": "Department of Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "SUN Jie",
                "org": "Department of Chemical Engineering,Shanghai University,Shanghai ,China"
            }
        ],
        "venue": "Chemical Researches",
        "year": 2005
    },
    "umN53UmA": {
        "id": "umN53UmA",
        "title": "Analysis of the Chemical Logistics Market Research in South China",
        "abstract": "In recent years,chemical logistics in a relatively quick period of development,have a good market demand,but the chemical logistics enterprises exist some problems,such as the concept backward,outdated facilities,and so on. In this paper,making a research in the South China chemical logistics market conditions,analysis of China's chemical logistics enterprises existing problems,the chemical combination of fierce competition in the logistics market,made a number of their superficial view.",
        "keywords": [
            "chemical",
            "green logistics",
            "South China",
            "logistics"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "School of Management,Shanghai University,Shanghai ,China"
            }
        ],
        "venue": "China Market",
        "year": 2008
    },
    "AlATW5ox": {
        "id": "AlATW5ox",
        "title": "Synthesis and Properties of Thermo-and pH-sensitive Hydrogel of Poly(vinyi alcohol) and Carboxymethylated Chitosan",
        "abstract": "Poly(vinyl alcohol)(PVA) and carboxymethylated chitosan(CMCh)(PVA/CMCH) hydrogel was prepared by irradiating the aqueous solution mixture of PVA and CMCh with()~(60)Co \u03b3-ray.The effect of feed ratio of PVA to CMCh,temperature,pH and the strength of ions on the swelling ratio of PVA/CMCh was studied.The hydrogel was thermo-and pH-sensitive.In deionized water,the hydrogel had a higher swelling ratio at 5\uff5e20\u00b0C and a lower swelling ratio above(20 \u00b0C),and the change was reversible.In pH buffer solution,the hydrogel swelled well with a higher swelling ratio pH<4.0 and pH>6.0,in the range of pH 4.0\uff5e6.0,however,the swelling ratio was relatively lower.",
        "keywords": [
            "poly(vinyl alcohol)",
            "pH-sensitivity",
            "thermo-sensitivity",
            "hydrogel",
            "carboxymethylated chitosan"
        ],
        "authors": [
            {
                "name": "WANG Sheng",
                "org": "Department of Chemical Engineering and Technology,School of Environmental and ChemicalEngineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "YANG Li-ming",
                "org": "Department of Chemical Engineering and Technology,School of Environmental and ChemicalEngineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Department of Chemical Engineering and Technology,School of Environmental and ChemicalEngineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "SUN Jie",
                "org": "Department of Chemical Engineering and Technology,School of Environmental and ChemicalEngineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "LI Zhi-jun",
                "org": "Department of Chemical Engineering and Technology,School of Environmental and ChemicalEngineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "WANG Tao",
                "org": "Department of Chemical Engineering and Technology,School of Environmental and ChemicalEngineering,Shanghai University,Shanghai ,China"
            }
        ],
        "venue": "Chemical World",
        "year": 2006
    },
    "YeyJoAXO": {
        "id": "YeyJoAXO",
        "title": "Radiation preparation and characterization of pH-sensitive hydrogel of acrylamide/\u03b2-cyclodextrin copolymer",
        "abstract": "A \u03b2-cyclodextrin (\u03b2-CD) based monomer (MAH-\u03b2-CD) containing vinyl and carboxyl functional groups was synthesized by reaction of \u03b2-CD with maleic anhydride (MAH). By copolymerization of the monomer with acrylamide (AAm), a novel hydrogel, poly(AAm-co-MAH-\u03b2-CD) with pH and ionic strength sensitivities plus molecular inclusion function, was obtained by irradiating the aqueous solution mixture of AAm and MAH-\u03b2-CD with electron beam. The effect of the feed ratio of components and irradiation dose on the swelling and deswelling properties of the hydrogel was systematically studied. Swelling ratio of the hydrogel was tested under different environment of pH and ionic strength. The results indicate that the copolymer hydrogels did not show any noticeable change in swelling at lower pH (pH<5). However, they showed an abrupt increase in swelling at pH 5-8 due to the ionization of carboxyl groups.",
        "keywords": [
            "\u03b2-Cyclodextrin",
            "Acrylamide",
            "Hydrogel",
            "Ionic strength-sensitivity",
            "pH-sensitivity",
            "Radiation"
        ],
        "authors": [
            {
                "name": "Ting Shan",
                "org": "Shanghai University(Shanghai University),Shanghai,China"
            },
            {
                "name": "Jie Chen",
                "org": "Shanghai University(Shanghai University),Shanghai,China"
            },
            {
                "name": "LiMing Yang",
                "org": "Shanghai University(Shanghai University),Shanghai,China"
            },
            {
                "name": "Shaowei W. Jie",
                "org": "Shanghai University(Shanghai University),Shanghai,China"
            },
            {
                "name": "Qiang Qian",
                "org": "Shanghai University(Shanghai University),Shanghai,China"
            },
            {
                "name": "Han Lin",
                "org": "Shanghai University(Shanghai University),Shanghai,China"
            },
            {
                "name": "Jinchen Fan",
                "org": "Shanghai University(Shanghai University),Shanghai,China"
            },
            {
                "name": "Fangqi Q. Cao",
                "org": "Shanghai University(Shanghai University),Shanghai,China"
            }
        ],
        "venue": "He Jishu/Nuclear Techniques",
        "year": 2008
    },
    "vJVkQNQp": {
        "id": "vJVkQNQp",
        "title": "Preparation and characterization of N-isopropylacrylamide/carboxymethylated chitosan hydrogel",
        "abstract": "Poly (N-isopropylacrylamide) (PNIPAAm)/carboxymethylated chitosan (CMCH) hydrogels were prepared by irradiating the aqueous solution mixture of NIPAAm and CMCH by 60Co \u03b3-ray. The effects of feed ratio of NIPAAm and CMCH, temperature, pH and ionic strength on the swelling ratio of PNIPAAm/CMCH hydrogels were studied. The results show that the addition of CMCH shifts the lower critical solution temperature (LCST) of the PNIPAAm hydrogel to higher temperature. The PNIPAAm/CMCH hydrogel displays not only pH- and thermo- sensitivity, but also ion-sensitivity. Differential scanning calorimetry (DSC) was applied for the determination of the LCST of the hydrogel. \u00a9 2010 Shanghai University and Springer-Verlag Berlin Heidelberg.",
        "keywords": [
            "Carboxymethylated chitosan (CMCH)",
            "Hydrogel temperature-sensitive",
            "N-isopropylacrylamide (NIPAAm)",
            "PH-sensitive"
        ],
        "authors": [
            {
                "name": "YANG Li-ming",
                "org": "Shanghai University(Shanghai University),Shanghai,China"
            },
            {
                "name": "Jie Chen",
                "org": "Shanghai University(Shanghai University),Shanghai,China"
            },
            {
                "name": "Sheng Wang",
                "org": "Shanghai University(Shanghai University),Shanghai,China"
            }
        ],
        "venue": "Journal of Shanghai University",
        "year": 2010
    },
    "ULx3ao3a": {
        "id": "ULx3ao3a",
        "title": "Radiation preparation and characterization of temperature-and pH-sensitive hydrogel of N-isopropylacrylamide/\u03b2-cyclodextrin copolymer",
        "abstract": "A hydrogel copolymer of N-isopropylacrylamide/\u03b2-cyclodextrin was prepared by radiation copoly-merization method. \u03b2-cyclodextrin (\u03b2-CD) based monomer (MAH-\u03b2-CD) containing vinyl and carboxyl functional groups was synthesized by modification of \u03b2-CD with maleic anhydride (MAH). And then the mixture aqueous solu-tion of NIPAAm and MAH-\u03b2-CD was irradiated by electron beams with BIS as cross-linking agent for sample of poly (NIPAAm-co-MAH-\u03b2-CD) hydrogel. The effects of temperature,pH and ionic strength on swelling ratio of the hy-drogel were determined meanwhile the effect of irradiation absorbed doses on its swelling and deswelling properties was also described. Experimental results show that the copolymer hydrogel possesses temperature,pH and ionic strength sensitive functions.",
        "keywords": [
            "\u03b2-Cyclodextri",
            "Radiation polymerization",
            "Temperature-sensitivity",
            "pH-sensitivity",
            "N-isopropylacrylamide",
            "Hydrogel"
        ],
        "authors": [
            {
                "name": "SHAN Ting",
                "org": "School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "YANG Liming",
                "org": "School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "QIAN Qiang",
                "org": "School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "JIE Shaowei",
                "org": "School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "LIN Han",
                "org": "School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "FAN Jinchen",
                "org": "School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "CAO Fangqi",
                "org": "School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Radiation Research and Radiation Processing",
        "year": 2008
    },
    "AtRFxtv9": {
        "id": "AtRFxtv9",
        "title": "Radiation synthesis of temperature-sensitive \u03b2-cyclodextrin-Grafted PEG/poly(N-isopropylacrylamide) hydrogels for drug delivery",
        "abstract": "In this paper, \u03b2-cyclodextrin(\u03b2-CD)-based water-soluble macromonomer(PEG-\u03b2-CD) was synthesized by reaction of \u03b2-CD with poly(ethylene glycol) diglycidyl ether(PEGDE).A novel temperature-sensitive hydrogel composed of PEG-\u03b2-CD and poly(N-isopropylacrylamide)(PNIPAAm) was prepared by E-beam irradiation.Compared with the normal PNIPAAm hydrogel, the obtained hydrogel had a high swelling ratio at room temperature and exhibited faster shrinking kinetics at temperature close to the lower critical solution temperature(LCST).5-fluorouracil(5-FU) was chosen as a model drug loaded into the hydrogels, and the release results showed the \u03b2-cyclodextrin-containing hydrogels prolonged the release time.",
        "keywords": [
            "\u03b2-Cyclodextrin",
            "Drug delivery",
            "Radiation polymerization",
            "N-isopropylacrylamide",
            "Temperature-sensitivity Hydrogel"
        ],
        "authors": [
            {
                "name": "LIN Han",
                "org": "School of Environmental and Chemical Engineering, Shanghai University, Shanghai , China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Environmental and Chemical Engineering, Shanghai University, Shanghai , China"
            },
            {
                "name": "QI Haoling",
                "org": "School of Environmental and Chemical Engineering, Shanghai University, Shanghai , China"
            },
            {
                "name": "SHEN Li",
                "org": "School of Environmental and Chemical Engineering, Shanghai University, Shanghai , China"
            },
            {
                "name": "FAN Jinchen",
                "org": "School of Environmental and Chemical Engineering, Shanghai University, Shanghai , China"
            },
            {
                "name": "CAO Fangqi",
                "org": "School of Environmental and Chemical Engineering, Shanghai University, Shanghai , China"
            }
        ],
        "venue": "Nuclear Techniques",
        "year": 2009
    },
    "dSjl8GXF": {
        "id": "dSjl8GXF",
        "title": "Effects of Blend Surfactant on Performance of CTAB and Three Different C12 Anionic Surfactants Complex Oil Displacing System",
        "abstract": "Properties of three kinds of surfactant composition systems with different hydrophilic group of anionic surfactant(sodium alkyl benzene sulfonate(ABS),sodium dodecyl sulfate(SDS),sodium dichloroisocyanurate(SDC)) and the same cationic surfactant cetyltriethyl ammonium bromide(CTAB) were studied.Compatibility,foam property,contact angle,surface tension and interfacial tension of the systems were measured.The results showed when the mol ratio of anionic and cationic surfactant was close to 1\u22361,the systems lost part of foam capacity while surface tension and interfacial tension reached the peak and contact angle was the lowest.The SDC-CTAB system reached ultra-low interfacial tension(IFT) with crude oil when the mass fraction of CTAB was in the range of 10% to 30% in the blend system.",
        "keywords": [
            "interfacial tension(IFT)",
            "foam properties",
            "anionic and cationic surfactant",
            "blend system",
            "molar ratio"
        ],
        "authors": [
            {
                "name": "GAO Wei",
                "org": "School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "MENG Qing-yang",
                "org": "School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "YANG Li-ming",
                "org": "School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "XU Yi",
                "org": "School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "CHEN Qi-hua",
                "org": "School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "XIANG Ming-hui",
                "org": "School of Environmental and Chemical Engineering,Shanghai University,Shanghai ,China"
            },
            {
                "name": "SONG Xin-wang",
                "org": "Shengli Oilfield Company of Geological Sciences,SINOPEC,Dongying ,Shandong,China"
            },
            {
                "name": "ZHU Yang-wen",
                "org": "Shengli Oilfield Company of Geological Sciences,SINOPEC,Dongying ,Shandong,China"
            }
        ],
        "venue": "Journal of Shanghai University(Natural Science Edition)",
        "year": 2010
    },
    "r4zF3otp": {
        "id": "r4zF3otp",
        "title": "Grafting copolymerization of N-isopropylacryamide onto preirradiated polypropylene fabric and Fe (II) adsorption",
        "abstract": "An ion adsorbed fabric of PP-g-NIPAAm was prepared by grafting N-isopropylacryamide (NIPAAm) onto PP (polypropylene) fabric pre-irradiated by 60Co \u03b3?rays. The ion adsorbility were studied on the Fe2+ aqueous solution with different conditions, such as temperature, pH and ion concentration etc. The results indicated that the NIPAAm grafted PP fabric possess the ability of adsorbing the Fe2+ ions at lower pH (around pH 0) and lower temperature(5 \u2103). The adsorbed Fe2+ ions were easily desorbed at higher temperature (50 \u2103).",
        "keywords": [
            "Adsorption",
            "Desorption",
            "NIPAAm",
            "Polypropylene (PP) fabric",
            "Radiation grafting"
        ],
        "authors": [
            {
                "name": "Tao Wang",
                "org": "Shanghai University(Shanghai University),Shanghai,China"
            },
            {
                "name": "Jie Chen",
                "org": "Shanghai University(Shanghai University),Shanghai,China"
            },
            {
                "name": "Simin He",
                "org": "Tianxiang Technology Service Co. Ltd.(Tianxiang Technology Service Co. Ltd.),Shanghai,China"
            },
            {
                "name": "LiMing Yang",
                "org": "Shanghai University(Shanghai University),Shanghai,China"
            },
            {
                "name": "Zhijun Li",
                "org": "Shanghai University(Shanghai University),Shanghai,China"
            },
            {
                "name": "Sheng Wang",
                "org": "Shanghai University(Shanghai University),Shanghai,China"
            },
            {
                "name": "Jiao Xu",
                "org": "Shanghai University(Shanghai University),Shanghai,China"
            }
        ],
        "venue": "Fushe Yanjiu yu Fushe Gongyi Xuebao/Journal of Radiation Research and Radiation Processing",
        "year": 2006
    },
    "x6lvLGBK": {
        "id": "x6lvLGBK",
        "title": "Robust Ni/WC superhydrophobic surfaces by electrodeposition",
        "abstract": "Superhydrophobic, water repellent surfaces have attracted much attention but poor surface mechanical properties have limited their wider practical application. Robust surfaces based on nickel\u2013tungsten carbide composite coatings have been electrodeposited. The surfaces showed superhydrophobicity after being modified by stearic acid. The maximum contact angle of water was 164.3 degrees with a sliding angle close to zero. By controlling the deposition conditions, versatile coatings have been produced and the effects of morphology on wettability are discussed. Coating texture has been analyzed by X-ray diffraction. The surfaces showed excellent abrasion resistance and water-repellence.",
        "keywords": "",
        "authors": [
            {
                "name": "Guochen Zhao",
                "org": "Shandong Key Laboratory for High Strength Lightweight Metallic Materials,Jinan,China"
            },
            {
                "name": "Guochen Zhao",
                "org": "Shandong Key Laboratory for High Strength Lightweight Metallic Materials,Jinan,China"
            },
            {
                "name": "Jinshang Li",
                "org": "School of Environmental and Chemical Engineering, Shanghai University,Shanghai,China"
            },
            {
                "name": "Yuanfeng Huang",
                "org": "Ocean College, Zhejiang University,,China"
            },
            {
                "name": "Liming Yang",
                "org": "School of Environmental and Chemical Engineering, Shanghai University,Shanghai,China"
            },
            {
                "name": "Ying Ye",
                "org": "Ocean College, Zhejiang University,,China"
            },
            {
                "name": "Frank C. Walsh",
                "org": "National Centre for Advanced Tribology at Southampton (nCATS), University of Southampton,,UK"
            },
            {
                "name": "Jie Chen",
                "org": "School of Environmental and Chemical Engineering, Shanghai University,Shanghai,China"
            },
            {
                "name": "S.C. Wang",
                "org": "National Centre for Advanced Tribology at Southampton (nCATS), University of Southampton,,UK"
            }
        ],
        "venue": "RSC Advances",
        "year": 2017
    },
    "163IMu1D": {
        "id": "163IMu1D",
        "title": "One-step electrodeposition of a self-cleaning and corrosion resistant Ni/WS2 superhydrophobic surface",
        "abstract": "Superhydrophobic surfaces have been intensively investigated for applications requiring self-cleaning and corrosion resistance. The techniques used to fabricate such a coating tend to be costly, time and energy consuming; further surface modification steps are often needed. In this study, a superhydrophobic composite electrodeposit based on tungsten disulphide nanoparticles dispersed in nickel on a mild steel substrate was successfully developed. At room temperature, the deposit showed a water contact angle of 158.3 deg and a sliding angle of 7.7 deg. The effects of operational parameters on surface morphology and superhydrophobicity are discussed. Compared to the substrate, the robust surface of the as-prepared coatings exhibited good self-cleaning and corrosion resistance, providing potential for industrial applications.",
        "keywords": "",
        "authors": [
            {
                "name": "Guochen Zhao",
                "org": "School of Environmental and Chemical Engineering, Shanghai University,Shanghai,China"
            },
            {
                "name": "Guochen Zhao",
                "org": "School of Environmental and Chemical Engineering, Shanghai University,Shanghai,China"
            },
            {
                "name": "Yanpeng Xue",
                "org": "Chemistry, Natural and Environmental Sciences, University of Southampton,,UK"
            },
            {
                "name": "Yuanfeng Huang",
                "org": "Ocean College, Zhejiang University,,China"
            },
            {
                "name": "Ying Ye",
                "org": "Ocean College, Zhejiang University,,China"
            },
            {
                "name": "Frank C. Walsh",
                "org": "National Centre for Advanced Tribology at Southampton (nCATS), University of Southampton,,UK"
            },
            {
                "name": "Jie Chen",
                "org": "School of Environmental and Chemical Engineering, Shanghai University,Shanghai,China"
            },
            {
                "name": "S.C. Wang",
                "org": "National Centre for Advanced Tribology at Southampton (nCATS), University of Southampton,,UK"
            }
        ],
        "venue": "RSC Advances",
        "year": 2016
    },
    "eL77fZNO": {
        "id": "eL77fZNO",
        "title": "Grade and characteristics of painted surface on monastery of buddhism in Wutai Mountain under imperial influence",
        "abstract": "Focused on painted surface on monastery of Han and Tibetan Buddhism in Wutai Mountain,based on systematic identification of existing examples,the paper summed up the grade division influenced by form and cost,the grade arrangement based on attention,and essential characteristics of the different grades under the exchange and fusion of Monastery and official paintings in late Qing Dynasty.Intended to form structural ways containing both official and vernacular paintings through their comparison,and provide technical guidelines of image and craft for the restoration and design of typical vernacular paintings in small-scale area and specific period.",
        "keywords": [
            "vernacular painting",
            "buddhism",
            "official painting",
            "Wutai Mountain",
            "painted surface"
        ],
        "authors": [
            {
                "name": "ZHANG Xin",
                "org": "Research Center for the World Cultural Heritage,Architecture Department,Beijing University of Technology,Beijing ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Cultural Heritage Department,China Central Academy of Fine Arts,Beijing ,China"
            }
        ],
        "venue": "Sichuan Building Science",
        "year": 2013
    },
    "uzB7MnhM": {
        "id": "uzB7MnhM",
        "title": "Vernacular Decorative Paintings of Shanxi Genres:Full Colored Painting in Buddhism Temples on Wutai Mount",
        "abstract": "With the study object of the full colored painting,a typical kind of vernacular decorative paintings of Shanxi genres,this article first induces contributing factors of religion,government and public under its historical background,then,discusses its classification,pattern,color and composition from the expression forms of sanctity,secularity and continuity.Finally,it analyzes the tangible and intangible attributes of vernacular decorative paintings and the significance of the research,and prospects the orientation of the overall conservation and development of vernacular decorative paintings and vernacular architectural heritages.",
        "keywords": [
            "Full colored painting",
            "Buddhism temple",
            "Shanxi Genres",
            "Decorative painting",
            "Wutai Mount",
            "Vernacular architecture"
        ],
        "authors": [
            {
                "name": "Zhang Xin",
                "org": ""
            },
            {
                "name": "Chen Jie",
                "org": ""
            }
        ],
        "venue": "Huazhong Architecture",
        "year": 2009
    },
    "iwaLHqDK": {
        "id": "iwaLHqDK",
        "title": "The Interpretation of Epigraphy Images on Painted Surface of Shanxi Merchants\u2019 Grand Courtyards",
        "abstract": "By introducing relevant archaeological knowledge and method in architectural research, and by using epigraphy images on painted surface of Shanxi merchants\u2019 grand courtyards as a starting point, this paper interprets its type and origin, analyzes the influence of Shanxi merchants\u2019 unique values and aesthetic fashion on the meaning of painted surfaces as well as the ideology of artisans, discusses the interaction between painted surface decoration and Shanxi merchants\u2019 culture in the transition of the society.",
        "keywords": [
            "heritage conservation",
            "image",
            "epigraphy",
            "Qiao\u2019s grand courtyard",
            "painted surface"
        ],
        "authors": [
            {
                "name": "Zhang Xin",
                "org": ""
            },
            {
                "name": "Chen Jie",
                "org": ""
            }
        ],
        "venue": "Architectural Journal",
        "year": 2012
    },
    "brawf0VF": {
        "id": "brawf0VF",
        "title": "ANALYSIS OF \"ZI REN YI ZHI\" IN JOINERY WORKS:Based on the Comparative Study of Its Counterparts in \"Ying Zao Fa Shi\"",
        "abstract": "The existing manuscript of joinery works in\"Zi Ren Yi Zhi(Woodworker's Bequeathal Skills)\",which Chen Mingda found contains two parts(the panelled door and the plank door) in more than 2600 words and 40 illustrations.Through the sentence-by-sentence interpretation and comparison between the relative chapters of\"Zi Ren Yi Zhi\"and\"Ying Zao Fa Shi\",their continuation is summarized,the characteristics of convex,decoration styles,proportion of partition board,manpower,and manufacture of members of the former are analyzed,and the succession and development of joinery work skills from Song to Yuan Dynasty are revealed.",
        "keywords": [
            "Ying Zao Fa Shi",
            "joinery work",
            "Zi Ren Yi Zhi",
            "panelled door",
            "plank door"
        ],
        "authors": [
            {
                "name": "Zhang Xin",
                "org": ""
            },
            {
                "name": "Chen Jie",
                "org": ""
            }
        ],
        "venue": "Architectural Journal",
        "year": 2009
    },
    "DqxH1lVj": {
        "id": "DqxH1lVj",
        "title": "Research on the Craftsmanship of World Cultural Heritage Sites: the Evolution and Development of Skill and Operational Mechanism of Stonework in Mount Wutai",
        "abstract": "Mount Wutai, which is among the World Cultural Heritage List, is one of the four famous Chinese Buddhist mountains. In order to serve the Buddhist temples around it, all sorts of crafts have come into being. Stone craft in particular, has achieved great success. Its skills are not only important part of existing cultural heritage, and intangible cultural heritage in particular, but also have practical value in the maintenance and development of vernacular feature in World Heritage Sites. Firstly, through dynamic empirical analysis and comparative study, this paper initially sorts out the evolution of traditional stone skills in Wutai Mountain area influenced by new technology. Secondly, through the comparison of various traditional and contemporary skills, the paper discusses their similarities and differences as well as advantages and disadvantages based on different technology. Finally, through the contrast of old and new constructive organization and income, it reveals the impact and consequences of modern marketing mechanisms on the organization and management of traditional stonework.",
        "keywords": [
            "Mechanism",
            "Techniques",
            "Mount Wuta",
            "World Cultural Heritage",
            "Stonework"
        ],
        "authors": [
            {
                "name": "Zhang Xin",
                "org": ""
            },
            {
                "name": "Chen Jie",
                "org": ""
            }
        ],
        "venue": "Huazhong Architecture",
        "year": 2011
    },
    "rSP7Lbnb": {
        "id": "rSP7Lbnb",
        "title": "Construction of Clan Temples under Clan Power\u2014\u2014Based on the Example of Jingsheng Village",
        "abstract": "Jingsheng town ranks first in the first List of Well-known Historical and Cultural Towns(Villages)jointly promulgated by the Ministry of Construction and the State Cultural Relics Bureau.The Jingsheng village that the present paper focuses on Is the seat of the local government of the Jingsheng town.In traditional society,the clan temples were of great importance to the conformation of village structure, and the fortune of them was basically decided by the power of clan.Keeping track with the development and evolution of different clan temples in Jingsheng village,the present paper discusses the function of clan power in the building of clan temples.",
        "keywords": [
            "Clan temple",
            "Clan",
            "Clan power"
        ],
        "authors": [
            {
                "name": "Chen Jie",
                "org": ""
            },
            {
                "name": "Zhang Xin",
                "org": ""
            }
        ],
        "venue": "Huazhong Architecture",
        "year": 2006
    },
    "EeAh4gnk": {
        "id": "EeAh4gnk",
        "title": "Evolution of Traditional Cave-House and Finalization of Courtyard House Residence",
        "abstract": "Based on the example of Jingsheng country,which is a typical vernacular settlement in the Loess Plateau in north China,authors analyzed the evolutional cause and finalization of traditional cave-houses,and revealed their governing factors.Through using anthropological means,authors discussed the sitting,spatial and environmental characteristics of cave-houses,the significance of heated kang in cave-house lives,the succession and development of open courtyards based on cave-houses,and the effect of geomantic omen and taboo on the layout of courtyard houses.The result indicates that the cave-house and heated kang are fundamental in the formation and development of dwelling system in the Loess Plateau in north China,while geomantic omen represented by \"dayounian means\" and taboo in traditional lives result in the finalization of courtyard house psychologically as well as practically.",
        "keywords": [
            "traditional cave-house",
            "Loess Plateau",
            "residential culture",
            "heated kang",
            "courtyard house",
            "geomantic omen"
        ],
        "authors": [
            {
                "name": "ZHANG Xin",
                "org": "Department of Architecture,Tongji University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Department of Architecture,Tongji University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Architecture and Civil Engineering",
        "year": 2006
    },
    "6K3uHQYy": {
        "id": "6K3uHQYy",
        "title": "The Change of Power and the Evolution of Village Structure:Jingsheng Village as an Example",
        "abstract": "The operation of social power in the village needs to have specific buildings that can serve as carriers,and these buildings then become nodes which control the village structure.The change of the power content and its operation in different historical periods leads to the trans- formation of various nodes,and hence the change of the whole village structure.Based on the study of the meaning and usage of different nodes during different periods in Jingsheng village,the paper discusses the interrelations of the materialization of power and the structure of the village.",
        "keywords": [
            "power node change",
            "village structure"
        ],
        "authors": [
            {
                "name": "Zhang Xin",
                "org": ""
            },
            {
                "name": "Chen Jie",
                "org": ""
            }
        ],
        "venue": "The Architect",
        "year": 2006
    },
    "itnNue0U": {
        "id": "itnNue0U",
        "title": "Structural features in site selection of temple in migrating tribes",
        "abstract": "From viewpoints of anthropology,based upon analysis of village marker and site selection method of temple the structural features of public buildings in migrating tribes.The influences of geomantic omen are also analyzed,which has a certain instruction action for research of ancient architecture.",
        "keywords": [
            "temple",
            "migrating tribes",
            "site selection"
        ],
        "authors": [
            {
                "name": "ZHANG Xin",
                "org": ""
            },
            {
                "name": "CHEN Jie",
                "org": ""
            }
        ],
        "venue": "Shanxi Architecture",
        "year": 2006
    },
    "TgsscqOl": {
        "id": "TgsscqOl",
        "title": "Out of the Ordinary\u2014\u2014Variation of Space in Shanxi Merchants Courtyard Houses",
        "abstract": "In traditional courtyard houses of the North China,the organization of space is highly conventionalization in Qing Dynasty,and the layout of space is becoming similar.However,some space organization of the Wang grand-courtyard is quite new and fresh.In the building group of the Wang grand-courtyard,the change of route,the utilization of arch and the construction of lavatory can all serve as good examples for the imagination of the builders.",
        "keywords": [
            "Arch",
            "Sahnxi Lingshi",
            "Wang grand-courtyard",
            "Shanxi Merchants",
            "Courtyard",
            "Route",
            "Space"
        ],
        "authors": [
            {
                "name": "Zhang Xin",
                "org": ""
            },
            {
                "name": "Chen Jie",
                "org": ""
            }
        ],
        "venue": "Huazhong Architecture",
        "year": 2006
    },
    "LQBWwJJt": {
        "id": "LQBWwJJt",
        "title": "Convergence and differentiation: the adjustment of Jingsheng commercial buildings to courtyard houses",
        "abstract": "The special layout commercial buildings under the influence of traditional culture and courtyard house as residence was studied at the anthropological point of view by focusing on various traditional commercial buildings including pawnshops,storefronts and special merchants' houses with strong defensive means preserved in Jingsheng Village.",
        "keywords": [
            "pawnshop",
            "courtyard house",
            "storefront",
            "merchants house"
        ],
        "authors": [
            {
                "name": "ZHANG Xin",
                "org": "Architecture Department of Tongji University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Architecture Department of Tongji University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Hebei Institute of Architectural Science and Technology",
        "year": 2006
    },
    "ihYiClJ1": {
        "id": "ihYiClJ1",
        "title": "The construction of migratory settlement by clan power:Jingsheng village as an example",
        "abstract": "Located in Lingshi county in shanxi province,Jingsheng town ranks first in the first list of well-known historical and cultural towns jointly promulgated by the Ministry of Construction and the State Administration of Cultural Heritage of China.Jingsheng village,however,is not only the seat of the government of Jingsheng town,but also a typical migratory settlement of the Loess Plateau in north China.From the sociological point of view,the present paper compares the different construction of residence with public buildings between two historical stages in Jingsheng village,and the function of clan power is also given due attention.",
        "keywords": [
            "migratory settlement",
            "clan power",
            "trade",
            "joss house",
            "clan temple"
        ],
        "authors": [
            {
                "name": "ZHANG Xin",
                "org": "College of Architecture and Urban Planning,Tongji University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Architecture and Urban Planning,Tongji University,Shanghai ,China"
            }
        ],
        "venue": "Journal of Shandong  Jianzhu University",
        "year": 2006
    },
    "yMHY4IXx": {
        "id": "yMHY4IXx",
        "title": "Investigation Method of Traditional Architectural Handicrafts",
        "abstract": "This paper explores the basic steps about con- sultation of historical documents, investigation on the spot and interview with craftsman in light of living examples, and the concrete way of place selection, work arrangement, information record and data storage, etc. for traditional handi- crafts investigation. It provides reference for conservation of traditional architectural heritage and sustainable devel- opment of traditional architectural handicrafts.",
        "keywords": [
            "architectural handicrafts",
            "conservation of heritage",
            "field investigation",
            "interview with craftsman"
        ],
        "authors": [
            {
                "name": "Zhang Xin",
                "org": ""
            },
            {
                "name": "Chen Jie",
                "org": ""
            }
        ],
        "venue": "Architectural Journal",
        "year": 2008
    },
    "Qsrv0Gbt": {
        "id": "Qsrv0Gbt",
        "title": "Characteristics of Thermal Decomposition of TEX",
        "abstract": "In-situ FTIR was employed to study the characteristics of thermal decomposition of TEX in the process of tempaerature programming.The thermal decomposition mechanism was deduced.The first step of TEX thermal decomposition was denitration,and the evolutaed gases were mainly NO_2,N_2O,HCN,NO,CO and aldehyde group-containing products.",
        "keywords": [
            "thermal decomposition mechanism",
            "in-situ FTIR",
            "TEX",
            "physical chemistry"
        ],
        "authors": [
            {
                "name": "ZUO Yu-fen",
                "org": "Institute of Chemical Materials,CAEP,Mianyang,,China"
            },
            {
                "name": "CHANG Kun",
                "org": "Institute of Chemical Materials,CAEP,Mianyang,,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Institute of Chemical Materials,CAEP,Mianyang,,China"
            },
            {
                "name": "CHENG Ke-mei",
                "org": "Institute of Chemical Materials,CAEP,Mianyang,,China"
            },
            {
                "name": "WANG Xin-feng",
                "org": "Institute of Chemical Materials,CAEP,Mianyang,,China"
            },
            {
                "name": "FANG Yong-xi",
                "org": "Institute of Chemical Materials,CAEP,Mianyang,,China"
            }
        ],
        "venue": "Chinese Journal of Energetic Materials",
        "year": 2006
    },
    "PzfjXLTE": {
        "id": "PzfjXLTE",
        "title": "Aging Performances of Ignition Composition",
        "abstract": "The performance of one squib\u2032s ignition composition in artificial accelerated aging test was studied by testing the aluminite powder content,ignitibility,thermal conductivity and electrostatic spark sensitivity.The results show that the ignitibility of ignition composition degrades,the aluminum powder content reduces and the thermal diffusivity of ignition composition increases with increasing the aging time under the conditions of temperature 60\u2103 and the relative humidity 95%.The electrostatic spark sensitivity of ignition composition increases with the increasing of aging time under the condition of low humidity surroundings.",
        "keywords": [
            "ignition composition",
            "coefficient of thermal conductivity",
            "physical chemistry",
            "electrostatic spark sensitivity",
            "firing performance",
            "pyrotechnics"
        ],
        "authors": [
            {
                "name": "TU Xiao-zhen",
                "org": "Institute of Chemical Materials,CAEP,Mianyang Sichuan ,China"
            },
            {
                "name": "ZHOU Mei-lin",
                "org": "Institute of Chemical Materials,CAEP,Mianyang Sichuan ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Institute of Chemical Materials,CAEP,Mianyang Sichuan ,China"
            },
            {
                "name": "SHEN Ming",
                "org": "Institute of Chemical Materials,CAEP,Mianyang Sichuan ,China"
            }
        ],
        "venue": "Chinese Journal of Explosives & Propellants",
        "year": 2011
    },
    "85ghH8kz": {
        "id": "85ghH8kz",
        "title": "Comparison of aging models of polymer bonded explosives",
        "abstract": "Three aging models, including Arrhenius, time-temperature superposition principle and neural network were used to comparatively study the aged HMX based PBX. And the lifetime was predicted when this explosives lost 0.1% of their total mass at 20\u00b0C and when the lost 0.2% of the total mass at 50\u00b0C and 60\u00b0C. Results show that the lifetime predicted from Arrhenius, time-temperature superposition principle, neural network are 390 years, 490 years and 15.2 years and 1127 d, 1180 d, 1375 d; and 182 d, 196 d, 220 d, respectively. It is stated that the results calculated by Arrhenius is agreed with that by Time-temperature superposition principle, and the neural network model is not an available when below the modeling temperature.",
        "keywords": [
            "Aging model",
            "Physical chemistry",
            "Polymer bonded explosive",
            "Storage lifetime"
        ],
        "authors": [
            {
                "name": "ZHANG Guo-hui",
                "org": "Southwest University of Science and Technology(Southwest University of Science and Technology),Mianyang,China"
            },
            {
                "name": "WEI Xing-wen",
                "org": "China Academy of Engineering Physics(China Academy of Engineering Physics,CAEP,China Acad. of Eng. Phys.),Chengdu,China"
            },
            {
                "name": "Jie Chen",
                "org": "China Academy of Engineering Physics(China Academy of Engineering Physics,CAEP,China Acad. of Eng. Phys.),Chengdu,China"
            },
            {
                "name": "SHU Yuan-jie",
                "org": "China Academy of Engineering Physics(China Academy of Engineering Physics,CAEP,China Acad. of Eng. Phys.),Chengdu,China"
            },
            {
                "name": "SONG Mian-xin",
                "org": "Southwest University of Science and Technology(Southwest University of Science and Technology),Mianyang,China"
            }
        ],
        "venue": "Hanneng Cailiao/Chinese Journal of Energetic Materials",
        "year": 2011
    },
    "gW07M8ai": {
        "id": "gW07M8ai",
        "title": "Thermal safety and compatibilities with silicone rubber cushion and polyurethane adhesive of PBX specimen based on HMX",
        "abstract": "The thermal safety of polymer bonded explosive (PBX) specimen based on HMX and their compatibility with contacted materials, silicone rubber cushion and polyurethane adhesive were investigated by on-line chemical reactivity test (CRT) detection device developed by the authors. The results show that the PBX specimen has a good thermal stability. The concentrations of CO 2 and N 2O evolved from the specimen are only 0.1 mL\u00b7g -1 after heated at 100\u00b0C for 1.15 months. In comparison with PBX specimen, the concentration of N 2O evolved from PBX specimen/silicone rubber cushion or polyurethane adhesive mixture has a very little increase, but the net gas evolution quantity of the two mixtures is small, indicating that PBX specimen and two contacted materials are compatible.",
        "keywords": [
            "Chemical reactivity test",
            "Compatibility",
            "PBX specimen",
            "Physical chemistry",
            "Polyurethane adhesive",
            "Silicone rubber cushion",
            "Thermal safety"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "China Academy of Engineering Physics(China Academy of Engineering Physics,CAEP,China Acad. of Eng. Phys.),Chengdu,China"
            },
            {
                "name": "Qiang Peng",
                "org": "China Academy of Engineering Physics(China Academy of Engineering Physics,CAEP,China Acad. of Eng. Phys.),Chengdu,China"
            },
            {
                "name": "Wen Qian",
                "org": "China Academy of Engineering Physics(China Academy of Engineering Physics,CAEP,China Acad. of Eng. Phys.),Chengdu,China"
            },
            {
                "name": "WANG Li-yan",
                "org": "China Academy of Engineering Physics(China Academy of Engineering Physics,CAEP,China Acad. of Eng. Phys.),Chengdu,China"
            },
            {
                "name": "ZUO Yu-fen",
                "org": "China Academy of Engineering Physics(China Academy of Engineering Physics,CAEP,China Acad. of Eng. Phys.),Chengdu,China"
            },
            {
                "name": "Yu Chi",
                "org": "China Academy of Engineering Physics(China Academy of Engineering Physics,CAEP,China Acad. of Eng. Phys.),Chengdu,China"
            }
        ],
        "venue": "Hanneng Cailiao/Chinese Journal of Energetic Materials",
        "year": 2011
    },
    "39IHX6GU": {
        "id": "39IHX6GU",
        "title": "Thermal ageing life evaluation and structure characterization of JOB-9003 explosive",
        "abstract": "Thermal decomposition of JOB-9003 explosive was studied at lower temperature range(60\u2103-90\u2103)and higher temperature range(110\u2103-140\u2103) by Bourdon manometer method respectively,and thermal ageing life of the explosive was evaluated.The gas species given off and the condensation phase at the lower temperature range were further analyzed by SPME-GC-MS and XPS.The results suggested that:1) JOB-9003 explosive possessed good thermal stability and its surface structures remained unchanged at 60\u2103-90\u2103;2) The storage life evaluated was 34.4 years for JOB-9003 explosive at 60\u2103 based on the decomposition depth of 0.1%.",
        "keywords": [
            "surface structures",
            "thermal stability",
            "thermal ageing life",
            "JOB-9003"
        ],
        "authors": [
            {
                "name": "ZUO Yu-fen",
                "org": "Institute of Chemical Materials,China Academy of Physical engineering,Mianyang,Sichuan ,China"
            },
            {
                "name": "XIONG ying",
                "org": "Institute of Chemical Materials,China Academy of Physical engineering,Mianyang,Sichuan ,China"
            },
            {
                "name": "FANG Yong-xi",
                "org": "Institute of Chemical Materials,China Academy of Physical engineering,Mianyang,Sichuan ,China"
            },
            {
                "name": "CHEN jie",
                "org": "Institute of Chemical Materials,China Academy of Physical engineering,Mianyang,Sichuan ,China"
            }
        ],
        "venue": "Chemical Research and Application",
        "year": 2010
    },
    "nkhwRHw5": {
        "id": "nkhwRHw5",
        "title": "Comparison of stability of BTF and PBX based on BTF",
        "abstract": "The stabilities of benzotrifuroxan(BTF) and the PBX based on BTF were compared.The Bourdon method was used to investigate the thermal decomposition of BTF and the PBX under vacuum conditions.Within the temperature range from 80 to120\u2103,the relationships between the time(\u03c4) corresponding to the reacted fraction of 0.1% and the temperature(T) of the thermal decomposition of BTF and the PBX can be expressed by the following equations:lg\u03c4=5.6144-0.05354T and lg\u03c4=5.6836-0.04865T.Therefore the storage lifes of BTF and the PBX at 30\u2103 extrapolated by Berthelot equation were seperately 27.9 years and 45.9 years.The results indicated that PBX based on BTF has better thermal stability than BTF.",
        "keywords": [
            "BTF",
            "storage life",
            "PBX",
            "stability"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "Institute of Chemical Materials,China Academy of Engineering Physics,Mianyang,Sichuan,,China"
            },
            {
                "name": "ZUO Yu-fen",
                "org": "Institute of Chemical Materials,China Academy of Engineering Physics,Mianyang,Sichuan,,China"
            },
            {
                "name": "LIU Jia-bin",
                "org": "Institute of Chemical Materials,China Academy of Engineering Physics,Mianyang,Sichuan,,China"
            },
            {
                "name": "ZHOU Jian-hua",
                "org": "Institute of Chemical Materials,China Academy of Engineering Physics,Mianyang,Sichuan,,China"
            },
            {
                "name": "PENG Qiang",
                "org": "Institute of Chemical Materials,China Academy of Engineering Physics,Mianyang,Sichuan,,China"
            },
            {
                "name": "HUANG Bo-yong",
                "org": "Institute of Chemical Materials,China Academy of Engineering Physics,Mianyang,Sichuan,,China"
            }
        ],
        "venue": "Chemical Research and Application",
        "year": 2010
    },
    "dXH7IVYi": {
        "id": "dXH7IVYi",
        "title": "Study on time and temperature effect between PBX specimen and polymer",
        "abstract": "The properties of PBX specimen,polymer and their contact system aged at different temperatures for different time were characterized by HPLC and XPS methods.The results show that:1)The mass and TNT content of PBX specimen decrease with the storage temperature rising,while the N element contents in the surface increase with the storage temperature rising;2)At constant temperature,the changes of these properties suspend after it reach a certain extent,which are mainly caused by sublimation and migration of some small molecules in PBX specimen and hardly influnced by the polymer.",
        "keywords": [
            "polymer",
            "time and temperature effect",
            "PBX specimen"
        ],
        "authors": [
            {
                "name": "ZUO Yu-fen",
                "org": "Institute of Chemical Materials,China Academy of Physical engineering,Mianyang,Sichuan ,China"
            },
            {
                "name": "CHEN jie",
                "org": "Institute of Chemical Materials,China Academy of Physical engineering,Mianyang,Sichuan ,China"
            },
            {
                "name": "XIONG ying",
                "org": "Institute of Chemical Materials,China Academy of Physical engineering,Mianyang,Sichuan ,China"
            },
            {
                "name": "CHI yu",
                "org": "Institute of Chemical Materials,China Academy of Physical engineering,Mianyang,Sichuan ,China"
            }
        ],
        "venue": "Chemical Research and Application",
        "year": 2011
    },
    "R9YdYo1u": {
        "id": "R9YdYo1u",
        "title": "Compatibility of HMX based PBX specimens and polyurethane gum",
        "abstract": "The curves of changes in exothermic mass and exothermic rate of polymer bonded expesive(PBX), polyurethane gum and their contacted system with time during the aging by 100 \u2103/20 d were obtained by a microcalorimeter. The samples before and after aging were tested by TG-DSC and FTIR. The results show that HMX based PBX and polyurethane is compatible. After being aged, the surface structures of HMX based PBX show no change, while the partial structures of polyurethane gum undergo degradation.",
        "keywords": [
            "Calorimetry",
            "Compatibility",
            "Infrared analysis",
            "Physical chemistry",
            "Polymer bond explosives (PBX)",
            "Polyurethane"
        ],
        "authors": [
            {
                "name": "ZUO Yu-fen",
                "org": "China Academy of Engineering Physics(China Academy of Engineering Physics,CAEP,China Acad. of Eng. Phys.),Chengdu,China"
            },
            {
                "name": "Ying Xiong",
                "org": "China Academy of Engineering Physics(China Academy of Engineering Physics,CAEP,China Acad. of Eng. Phys.),Chengdu,China"
            },
            {
                "name": "Jie Chen",
                "org": "China Academy of Engineering Physics(China Academy of Engineering Physics,CAEP,China Acad. of Eng. Phys.),Chengdu,China"
            },
            {
                "name": "XIA Jing-qiong",
                "org": "China Academy of Engineering Physics(China Academy of Engineering Physics,CAEP,China Acad. of Eng. Phys.),Chengdu,China"
            },
            {
                "name": "Lin Wang",
                "org": "China Academy of Engineering Physics(China Academy of Engineering Physics,CAEP,China Acad. of Eng. Phys.),Chengdu,China"
            }
        ],
        "venue": "Hanneng Cailiao/Chinese Journal of Energetic Materials",
        "year": 2012
    },
    "VoX84YTq": {
        "id": "VoX84YTq",
        "title": "Principal Component Analysis of Plasma Cytokine Changes During Hypofractionated SBRT in Patients With Non-Small Cell Lung Cancer: Is There a Difference From Conventionally Fractionated Radiation?",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B.M. Rabatic",
                "org": "Georgia Regents University, Augusta, GA"
            },
            {
                "name": "J. Chen",
                "org": "Georgia Regents University, Augusta, GA"
            },
            {
                "name": "S. Wang",
                "org": "Cancer Hospital & Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"
            },
            {
                "name": "P. Stanton",
                "org": "University of Michigan, Ann Arbor, MI"
            },
            {
                "name": "F.P. Kong",
                "org": ""
            },
            {
                "name": "F.P. Kong",
                "org": ""
            }
        ],
        "venue": "International Journal of Radiation Oncology Biology Physics",
        "year": 2015
    },
    "SpSePnBt": {
        "id": "SpSePnBt",
        "title": "A Novel Radiation Pneumonitis Predictive Model With MLD and IL-8 for Non-Small Cell Lung Cancer Patients",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "S.L. Wang",
                "org": ""
            },
            {
                "name": "S.L. Wang",
                "org": ""
            },
            {
                "name": "Matthew H. Stenmark",
                "org": ""
            },
            {
                "name": "J. Chen",
                "org": ""
            },
            {
                "name": "J. Lee",
                "org": ""
            },
            {
                "name": "P. Stanton",
                "org": ""
            },
            {
                "name": "Jing Zhao",
                "org": ""
            },
            {
                "name": "M.M. Matuszak",
                "org": ""
            },
            {
                "name": "R.K. Ten Haken",
                "org": ""
            },
            {
                "name": "F.P. Kong",
                "org": ""
            }
        ],
        "venue": "International Journal of Radiation Oncology Biology Physics",
        "year": 2015
    },
    "AbFIVoOY": {
        "id": "AbFIVoOY",
        "title": "Principal component analysis identifies patterns of cytokine expression in non-small cell lung cancer patients undergoing definitive radiation therapy.",
        "abstract": "PCA can identify potentially significant patterns of cytokine expression after fractionated RT. Our PCA showed that inflammatory cytokines dominate post-treatment cytokine profiles, and the changes differ after SBRT versus CFRT, with vs without chemotherapy. Further studies are planned to validate these findings and determine the clinical significance of the cytokine profiles identified by PCA.",
        "keywords": "",
        "authors": [
            {
                "name": "Susannah G Ellsworth",
                "org": "Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indianapolis, United States of America."
            },
            {
                "name": "Bryan M Rabatic",
                "org": "Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina, United States of America."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Biostatistics & Epidemiology, Augusta University; Augusta, Georgia, United States of America."
            },
            {
                "name": "Jing Zhao",
                "org": "Department of Radiation Oncology, Augusta University, Augusta, Georgia, United States of America."
            },
            {
                "name": "Jeffrey Campbell",
                "org": "Department of Radiation Oncology, Augusta University, Augusta, Georgia, United States of America."
            },
            {
                "name": "Weili Wang",
                "org": "Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indianapolis, United States of America."
            },
            {
                "name": "Wenhu Pi",
                "org": "Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indianapolis, United States of America."
            },
            {
                "name": "Paul Stanton",
                "org": "Department of Radiation Oncology, Augusta University, Augusta, Georgia, United States of America."
            },
            {
                "name": "Martha Matuszak",
                "org": "Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, United States of America."
            },
            {
                "name": "Shruti Jolly",
                "org": "Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, United States of America."
            },
            {
                "name": "Amy Miller",
                "org": "Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indianapolis, United States of America."
            },
            {
                "name": "Feng-Ming Kong",
                "org": "Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indianapolis, United States of America."
            }
        ],
        "venue": "PloS one",
        "year": 2017
    },
    "FEEILntF": {
        "id": "FEEILntF",
        "title": "Prognostic value of cytokine profile on survival in non-small cell lung cancer patients treated with radiotherapy.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Shulian Wang",
                "org": "Department of Radiation Oncology, GRU Cancer Center and Medical College of Georgia, Augusta, GA"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Biostatistics, GRU Cancer Center and Medical College of Georgia, Augusta, GA"
            },
            {
                "name": "Randall K Ten Haken",
                "org": "Department of Radiation Oncology, University of Michigan, Ann Arbor, MI"
            },
            {
                "name": "Paul Stanton",
                "org": "Department of Radiation Oncology, GRU Cancer Center and Medical College of Georgia, Augusta, GA"
            },
            {
                "name": "Feng Ming Kong",
                "org": "GRU Cancer Center and Medical College of Georgia, Augusta, GA"
            }
        ],
        "venue": "Journal of Clinical Oncology",
        "year": 2015
    },
    "ja4eVsvz": {
        "id": "ja4eVsvz",
        "title": "Use a survival model to correlate single-nucleotide polymorphisms of DNA repair genes with radiation dose-response in patients with non-small cell lung cancer.",
        "abstract": "We have developed a survival model that may be used to identify genomic markers, such as ERCC1/2 SNPs, to predict radiation dose-response and potentially guide personalized radiotherapy.",
        "keywords": [
            "Biomarker",
            "Dose survival model",
            "ERCC1 and ERCC2",
            "Personalized radiotherapy",
            "Radiosensitivity",
            "Single-nucleotide-polymorphisms (SNPs)"
        ],
        "authors": [
            {
                "name": "Jian-Yue Jin",
                "org": "Department of Radiation Oncology, Georgia Regents University, Augusta, United States."
            },
            {
                "name": "Weili Wang",
                "org": "Department of Radiation Oncology, University of Michigan, Ann Arbor, United States."
            },
            {
                "name": "Randall K Ten Haken",
                "org": "Department of Radiation Oncology, University of Michigan, Ann Arbor, United States."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Biostatistics and Epidemiology, Georgia Regents University, Augusta, United States."
            },
            {
                "name": "Nan Bi",
                "org": "Department of Radiation Oncology, University of Michigan, Ann Arbor, United States."
            },
            {
                "name": "Ramses Sadek",
                "org": "Department of Biostatistics and Epidemiology, Georgia Regents University, Augusta, United States."
            },
            {
                "name": "Hong Zhang",
                "org": "Department of Radiation Oncology, Georgia Regents University, Augusta, United States."
            },
            {
                "name": "Theodore S Lawrence",
                "org": "Department of Radiation Oncology, University of Michigan, Ann Arbor, United States."
            },
            {
                "name": "Feng-Ming Spring Kong",
                "org": "Department of Radiation Oncology, Georgia Regents University, Augusta, United States. Electronic address: Fkong@gru.edu."
            }
        ],
        "venue": "Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology",
        "year": 2015
    },
    "2gV2Xox1": {
        "id": "2gV2Xox1",
        "title": "Effects of Fractionation Schedule on Expression Patterns of Clinically Significant Circulating Cytokines During Radiation Therapy for Lung Cancer",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "S. Ellsworth",
                "org": ""
            },
            {
                "name": "J. Chen",
                "org": ""
            },
            {
                "name": "W. Wang",
                "org": ""
            },
            {
                "name": "M.M. Matuszak",
                "org": ""
            },
            {
                "name": "R.K. Ten Haken",
                "org": ""
            },
            {
                "name": "Shruti Jolly",
                "org": ""
            },
            {
                "name": "F.M. Kong",
                "org": ""
            }
        ],
        "venue": "International Journal of Radiation Oncology Biology Physics",
        "year": 2017
    },
    "kleFdWqH": {
        "id": "kleFdWqH",
        "title": "Online system identification under non-negativity and \u21131-norm constraints algorithm and weight behavior analysis",
        "abstract": "Information processing with \u21131-norm constraint has been a topic of considerable interest during the last five years since it produces sparse solutions. Non-negativity constraints are also desired properties that can usually be imposed due to inherent physical characteristics of real-life phenomena. In this paper, we investigate an online method for system identification subject to these two families of constraints. Our approach differs from existing techniques such as projected-gradient algorithms in that it does not require any extra projection onto the feasible region. The mean weight-error behavior is analyzed analytically. Experimental results show the advantage of our approach over some existing algorithms. Finally, an application to hyperspectral data processing is considered.",
        "keywords": [
            "gradient methods",
            "identification",
            "\u21131-norm constraints algorithm",
            "hyperspectral data processing",
            "information processing",
            "mean weight-error behavior analysis",
            "nonnegativity constraints",
            "online system identification"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "university of nice sophia antipolis"
            },
            {
                "name": "C\u00e9dric Richard",
                "org": "university of nice sophia antipolis"
            },
            {
                "name": "Henri Lant\u00e9ri",
                "org": "university of nice sophia antipolis"
            },
            {
                "name": "C\u00e9line Theys",
                "org": "university of nice sophia antipolis"
            },
            {
                "name": "Paul Honeine",
                "org": "centre national de la recherche scientifique"
            }
        ],
        "venue": "EUSIPCO",
        "year": 2011
    },
    "jFD6hspv": {
        "id": "jFD6hspv",
        "title": "Abnormal Event Detection via Multikernel Learning for Distributed Camera Networks",
        "abstract": "Distributed camera networks play an important role in public security surveillance. Analyzing video sequences from cameras set at different angles will provide enhanced performance for detecting abnormal events. In this paper, an abnormal detection algorithm is proposed to identify unusual events captured by multiple cameras. The visual event is summarized and represented by the histogram of the optical flow orientation descriptor, and then a multikernel strategy that takes the multiview scenes into account is proposed to improve the detection accuracy. A nonlinear one-class SVM algorithm with the constructed kernel is then trained to detect abnormal frames of video sequences. We validate and evaluate the proposed method on the video surveillance dataset PETS.",
        "keywords": [],
        "authors": [
            {
                "name": "tian wang",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "paul honeine",
                "org": ""
            },
            {
                "name": "hichem snoussi",
                "org": ""
            }
        ],
        "venue": "IJDSN",
        "year": 2015
    },
    "CzhBbyy2": {
        "id": "CzhBbyy2",
        "title": "Online detection of abnormal events in video streams",
        "abstract": "We propose an algorithm to handle the problem of detecting abnormal events, which is a challenging but important subject in video surveillance. The algorithm consists of an image descriptor and online nonlinear classification method. We introduce the covariance matrix of the optical flow and image intensity as a descriptor encoding moving information. The nonlinear online support vectormachine (SVM) firstly learns a limited set of the training frames to provide a basic reference model then updates the model and detects abnormal events in the current frame. We finally apply the method to detect abnormal events on a benchmark video surveillance dataset to demonstrate the effectiveness of the proposed technique.",
        "keywords": [
            "descriptor encoding",
            "detects abnormal event",
            "video surveillance",
            "nonlinear online support vectormachine",
            "image intensity",
            "benchmark video surveillance dataset",
            "online nonlinear classification method",
            "basic reference model",
            "video stream",
            "image descriptor",
            "abnormal event",
            "online detection"
        ],
        "authors": [
            {
                "name": "Tian Wang",
                "org": "Institut Charles Delaunay, LM2S-UMR STMR 6279 CNRS, University of Technology of Troyes, Troyes, France"
            },
            {
                "name": "Jie Chen",
                "org": "Observatoire de la C\u00f4te d'Azur, UMR 7293 CNRS, University of Nice Sophia-Antipolis, Nice, France"
            },
            {
                "name": "Hichem Snoussi",
                "org": "Institut Charles Delaunay, LM2S-UMR STMR 6279 CNRS, University of Technology of Troyes, Troyes, France"
            }
        ],
        "venue": "J. Electrical and Computer Engineering",
        "year": 2013
    },
    "kxr7g5sW": {
        "id": "kxr7g5sW",
        "title": "A decentralized approach for nonlinear prediction of time series data in sensor networks",
        "abstract": "Wireless sensor networks rely on sensor devices deployed in an environment to support sensing and monitoring, including temperature, humidity, motion, and acoustic. Here, we propose a new approach to model physical phenomena and track their evolution by taking advantage of the recent developments of pattern recognition for nonlinear functional learning. These methods are, however, not suitable for distributed learning in sensor networks as the order of models scales linearly with the number of deployed sensors and measurements. In order to circumvent this drawback, we propose to design reduced order models by using an easy to compute sparsification criterion. We also propose a kernel-based least-mean-square algorithm for updating the model parameters using data collected by each sensor. The relevance of our approach is illustrated by two applications that consist of estimating a temperature distribution and tracking its evolution over time.",
        "keywords": [
            "wireless sensor network",
            "decentralized approach",
            "model parameter",
            "models scales linearly",
            "sensor network",
            "kernel-based least-mean-square algorithm",
            "new approach",
            "nonlinear prediction",
            "order model",
            "sensor device",
            "time series data",
            "nonlinear functional learning",
            "temperature distribution"
        ],
        "authors": [
            {
                "name": "Paul Honeine",
                "org": "Institut Charles Delaunay, Universit\u00e9 de Technologie de Troyes, UMR CNRS, Troyes Cedex, France"
            },
            {
                "name": "C\u00e9dric Richard",
                "org": "Fizeau Laboratory, Observatoire de la C\u00f4te d'Azur, Universit\u00e9 de Nice Sophia-Antipolis, UMR CNRS, Nice, France"
            },
            {
                "name": "Jos\u00e9 Carlos M. Bermudez",
                "org": "Department of Electrical Engineering, Federal University of Santa Catarina, Florian\u00f3polis, SC, Brazil"
            },
            {
                "name": "Jie Chen",
                "org": "Fizeau Laboratory, Observatoire de la C\u00f4te d'Azur, Universit\u00e9 de Nice Sophia-Antipolis, UMR CNRS, Nice, France"
            },
            {
                "name": "Hichem Snoussi",
                "org": "Institut Charles Delaunay, Universit\u00e9 de Technologie de Troyes, UMR CNRS, Troyes Cedex, France"
            }
        ],
        "venue": "EURASIP J. Wireless Comm. and Networking",
        "year": 2010
    },
    "feKyo9Ab": {
        "id": "feKyo9Ab",
        "title": "Nonnegative Least-Mean-Square Algorithm",
        "abstract": "Dynamic system modeling plays a crucial role in the development of techniques for stationary and nonstationary signal processing. Due to the inherent physical characteristics of systems under investigation, nonnegativity is a desired constraint that can usually be imposed on the parameters to estimate. In this paper, we propose a general method for system identification under nonnegativity constraints. We derive the so-called nonnegative least-mean-square algorithm (NNLMS) based on stochastic gradient descent, and we analyze its convergence. Experiments are conducted to illustrate the performance of this approach and consistency with the analysis.",
        "keywords": [
            "dynamic system modeling",
            "nonstationary signal processing",
            "signal processing",
            "system identification",
            "general method",
            "parameter estimation",
            "nonnegative constraints",
            "least mean square algorithms",
            "adaptive signal processing",
            "nonnegativity constraint",
            "adaptive filters",
            "so-called nonnegative least-mean-square algorithm",
            "crucial role",
            "nonnegative least-mean-square algorithm",
            "least mean squares methods",
            "gradient methods",
            "inherent physical characteristic",
            "stochastic gradient descent",
            "transient analysis",
            "algorithm design and analysis",
            "prediction algorithms",
            "adaptive filter",
            "algorithm design",
            "mathematical model",
            "convergence",
            "least squares approximation",
            "dynamic system",
            "least mean square"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Institut Charles Delaunay, CNRS, University of Technology of Troyes, Troyes cedex, France"
            },
            {
                "name": "C\u00e9dric Richard",
                "org": "C\u00f4te d'Azur Observatory, CNRS, University of Nice Sophia-Antipolis, Nice cedex 2, France"
            },
            {
                "name": "Jos\u00e9 Carlos M. Bermudez",
                "org": "Department of Electrical Engineering, Federal University of Santa Catarina, Florian\u00f3polis, Brazil"
            },
            {
                "name": "Paul Honeine",
                "org": "Institut Charles Delaunay, CNRS, University of Technology of Troyes, Troyes cedex, France"
            }
        ],
        "venue": "IEEE Transactions on Signal Processing",
        "year": 2011
    },
    "ibgN0rsh": {
        "id": "ibgN0rsh",
        "title": "Online least squares one-class support vector machines-based abnormal visual event detection.",
        "abstract": "The abnormal event detection problem is an important subject in real-time video surveillance. In this paper, we propose a novel online one-class classification algorithm, online least squares one-class support vector machine (online LS-OC-SVM), combined with its sparsified version (sparse online LS-OC-SVM). LS-OC-SVM extracts a hyperplane as an optimal description of training objects in a regularized least squares sense. The online LS-OC-SVM learns a training set with a limited number of samples to provide a basic normal model, then updates the model through remaining data. In the sparse online scheme, the model complexity is controlled by the coherence criterion. The online LS-OC-SVM is adopted to handle the abnormal event detection problem. Each frame of the video is characterized by the covariance matrix descriptor encoding the moving information, then is classified into a normal or an abnormal frame. Experiments are conducted, on a two-dimensional synthetic distribution dataset and a benchmark video surveillance dataset, to demonstrate the promising results of the proposed online LS-OC-SVM method.",
        "keywords": [
            "abnormal detection",
            "covariance matrix descriptor",
            "online least squares one-class svm",
            "optical flow"
        ],
        "authors": [
            {
                "name": "Tian Wang",
                "org": "Universite de Technologie de Troyes(Universit\u00e9 de Technologie de Troyes,University of Technology of Troyes,Universite de Technologie de Troyes),Troyes,France"
            },
            {
                "name": "Jie Chen",
                "org": "Universit\u00e9 Nice Sophia Antipolis(Universit\u00e9 de Nice,Universit\u00e9 de Nice-Sophia Antipolis),Nice,France"
            },
            {
                "name": "Yi Zhou",
                "org": "Dalian Maritime University(Dalian Maritime University),Dalian,China"
            },
            {
                "name": "Hichem Snoussi",
                "org": "Universite de Technologie de Troyes(Universit\u00e9 de Technologie de Troyes,University of Technology of Troyes,Universite de Technologie de Troyes),Troyes,France"
            }
        ],
        "venue": "Sensors",
        "year": 2013
    },
    "9DCGBxT9": {
        "id": "9DCGBxT9",
        "title": "System identification under non-negativity constraints",
        "abstract": "Dynamic system modeling plays a crucial role in the development of techniques for stationary and non-stationary signal processing. Due to the inherent physical characteristics of systems usually under investigation, non-negativity is a desired constraint that can be imposed on the parameters to estimate. In this paper, we propose a general method for system identification under non-negativity constraints. We derive additive and multiplicative weight update algorithms, based on (stochastic) gradient descent of mean-square error or Kullback-Leibler divergence. Experiments are conducted to validate the proposed approach.",
        "keywords": [],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "university of nice sophia antipolis"
            },
            {
                "name": "C\u00e9dric Richard",
                "org": "university of nice sophia antipolis"
            },
            {
                "name": "Paul Honeine",
                "org": "centre national de la recherche scientifique"
            },
            {
                "name": "Henri Lant\u00e9ri",
                "org": "university of nice sophia antipolis"
            },
            {
                "name": "C\u00e9line Theys",
                "org": "university of nice sophia antipolis"
            }
        ],
        "venue": "European Signal Processing Conference",
        "year": 2010
    },
    "BPTcEPh6": {
        "id": "BPTcEPh6",
        "title": "Variants of Non-Negative Least-Mean-Square Algorithm and Convergence Analysis",
        "abstract": "Due to the inherent physical characteristics of systems under investigation, non-negativity is one of the most interesting constraints that can usually be imposed on the parameters to estimate. The Non-Negative Least-Mean-Square algorithm (NNLMS) was proposed to adaptively find solutions of a typical Wiener filtering problem but with the side constraint that the resulting weights need to be non-negative. It has been shown to have good convergence properties. Nevertheless, certain practical applications may benefit from the use of modified versions of this algorithm. In this paper, we derive three variants of NNLMS. Each variant aims at improving the NNLMS performance regarding one of the following aspects: sensitivity of input power, unbalance of convergence rates for different weights and computational cost. We study the stochastic behavior of the adaptive weights for these three new algorithms for non-stationary environments. This study leads to analytical models to predict the first and second order moment behaviors of the weights for Gaussian inputs. Simulation results are presented to illustrate the performance of the new algorithms and the accuracy of the derived models.",
        "keywords": [
            "wiener filtering problem",
            "exponential algorithm",
            "nnlms",
            "nonstationary environments",
            "stochastic processes",
            "computational cost",
            "parameter estimation",
            "stochastic behavior",
            "convergence analysis",
            "wiener filters",
            "nonnegative least-mean-square algorithm",
            "normalized algorithm",
            "convergence",
            "least mean squares methods",
            "adaptive weights",
            "least-mean-square algorithms",
            "non-negativity constraints",
            "sign-sign algorithm",
            "gaussian inputs",
            "adaptive signal processing"
        ],
        "authors": [
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "C\u00e9dric Richard",
                "org": ""
            },
            {
                "name": "Jos\u00e9 Carlos M. Bermudez",
                "org": ""
            },
            {
                "name": "Paul Honeine",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Signal Processing",
        "year": 2014
    },
    "bGmp6tke": {
        "id": "bGmp6tke",
        "title": "European medical device market surveillance and its implication for China",
        "abstract": "To provide reference for China's market surveillance system.We introduce and analyze European's medical device market surveillance system as well as make comparison with China's system,China should establish medical device 's market surveillance and network systematically based on Europe and international experience.",
        "keywords": [
            "Market Surveillance",
            "Implication",
            "Medical device",
            "Europe"
        ],
        "authors": [
            {
                "name": "MI Xianqiang",
                "org": ",et al. School of Public Healt'h,Fudan University,Shanghai,,China"
            },
            {
                "name": "CHEN Jie",
                "org": ",et al. School of Public Healt'h,Fudan University,Shanghai,,China"
            },
            {
                "name": "PAN Erdun",
                "org": ",et al. School of Public Healt'h,Fudan University,Shanghai,,China"
            }
        ],
        "venue": "Chinese Health Quality Management",
        "year": 2009
    },
    "mIkCKhjg": {
        "id": "mIkCKhjg",
        "title": "The combination application of AHP and Delphi Method in eastablishing the hospital brand effect evaluation System",
        "abstract": "Objective:To assess the hospital brand,it still lacks quantitative measurement systems of indicators.This study is to establish a scientific and objective evaluation index system for the hospital brand effect.Methods: Through combined application of Delphi Method and AHP(analytic hierarchy process,AHP) to establish evaluation index system for the hospital brand effect.Results: Establish the hospital brand evaluation index system by combination of qualitative and quantitative ways.The importance of each index followed by technology,services,size,price,image,public relations.",
        "keywords": [
            "Delphi Method",
            "Evaluation system",
            "Hospital brand",
            "AHP(Analytic Hierarchy Process)"
        ],
        "authors": [
            {
                "name": "YU Fei",
                "org": "The Tenth People's Hospital Affiliated to Tongji University,Shanghai,,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Public Health,Fudan University,Shanghai ,China"
            },
            {
                "name": "CHEN Ying-yao",
                "org": "School of Public Health,Fudan University,Shanghai ,China"
            },
            {
                "name": "SHEN Ying-chun",
                "org": "The Tenth People's Hospital Affiliated to Tongji University,Shanghai,,China"
            },
            {
                "name": "CHEN Tong",
                "org": "The Tenth People's Hospital Affiliated to Tongji University,Shanghai,,China"
            },
            {
                "name": "HE Ping",
                "org": "The Tenth People's Hospital Affiliated to Tongji University,Shanghai,,China"
            },
            {
                "name": "SHENG Xing",
                "org": "The Tenth People's Hospital Affiliated to Tongji University,Shanghai,,China"
            }
        ],
        "venue": "Chinese Health Resources",
        "year": 2010
    },
    "ABocCiTJ": {
        "id": "ABocCiTJ",
        "title": "Comparison and analysis American and China's medical device registration system",
        "abstract": "To provide reference for China's medical device registration system.Comarision and analyze American and China's medical device registration system.China should learn from American medical device's registration system and improve its system.",
        "keywords": [
            "Registration",
            "Comparison and analysis",
            "Medical device"
        ],
        "authors": [
            {
                "name": "MI Xianqiang",
                "org": ",et al. School of Public Health,Fudan University,Shanghai,,China"
            },
            {
                "name": "CHEN Jie",
                "org": ",et al. School of Public Health,Fudan University,Shanghai,,China"
            },
            {
                "name": "PAN Erdun",
                "org": ",et al. School of Public Health,Fudan University,Shanghai,,China"
            }
        ],
        "venue": "Chinese Health Quality Management",
        "year": 2009
    },
    "n3GBGecf": {
        "id": "n3GBGecf",
        "title": "Study on establishing indicator system for comprehensive evaluation of information in community health centers in Shanghai",
        "abstract": "Objective: To establish an indicator system for comprehensive evaluation of the information level at community health centers in Shanghai and provide administrative tool to promote the information development.Methods: The indicator system was developed by literature review and focus group discussion and was optimized by Delphi method.The weight for the class \u2160 and class \u2161 indicators was defined by AHP method.Results: An indicator system with 6 class \u2160 indicators,19 class \u2161 indicators and 59 class \u2162 indicators was set up.Conclusion: This study helps us to develop an indicator system for comprehensive evaluation of information at the level of community health centers.",
        "keywords": [
            "Information level",
            "Community health center",
            "Indicator system",
            "Comprehensive evaluation"
        ],
        "authors": [
            {
                "name": "XIA Zhi-yuan",
                "org": "School of Public Health,Fudan University,Key Lab of Health Technology Assessment,Ministry of Health,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Public Health,Fudan University,Key Lab of Health Technology Assessment,Ministry of Health,Shanghai ,China"
            },
            {
                "name": "FAN Qi-yong",
                "org": "Information Center,Shanghai Municipal Health Bureau,Shanghai ,China"
            }
        ],
        "venue": "Chinese Health Resources",
        "year": 2011
    },
    "sdIpZ0XO": {
        "id": "sdIpZ0XO",
        "title": "Analysis on health resource allocation in different level hospital's laboratory",
        "abstract": "Objectives:To investigate the status of health resource allocation in laboratories at different level hospitals to provide evidence for government to make appropriate health resource allocation.Methods:To collect the data from ten sampling hospitals through typical survey.Focus group discussion was applied for consuhation.Re- suits:There are lower working time,education background,and professional title among clinics.Professionals top three equipments are blood cell analyzer,clinical chemistry analyzer and urine analyzer.Conclusions:Health re- source allocation in hospital should be based on the characteristics of different hospital levels.",
        "keywords": [
            "Clinic laboratories",
            "Hospital",
            "Resource allocation"
        ],
        "authors": [
            {
                "name": "WANG Xu-sheng",
                "org": "School of Public Health, Fudan University, Shanghai , China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Public Health, Fudan University, Shanghai , China"
            },
            {
                "name": "TANG Zhi-liu",
                "org": "School of Public Health, Fudan University, Shanghai , China"
            }
        ],
        "venue": "Chinese Health Resources",
        "year": 2008
    },
    "SWm6ROZP": {
        "id": "SWm6ROZP",
        "title": "Status quo and characteristics of Clinical Pathway study",
        "abstract": "Clinical Pathway is a new-style DRGs. This paper explains the theoretical framework, the background and the characteristic of clinical pathway, and the research condition is introduced based on the result of literature review. Then several advices are referred about the development of clinical pathway in China.",
        "keywords": [
            "DRGs",
            "quality",
            "cost",
            "clinical pathway"
        ],
        "authors": [
            {
                "name": "HUANG Jiayan",
                "org": " Sanitation College of Fudan University,Shanghai, ,PRC"
            },
            {
                "name": "CHEN Jie",
                "org": " Sanitation College of Fudan University,Shanghai, ,PRC"
            },
            {
                "name": "CHEN Yingyao",
                "org": " Sanitation College of Fudan University,Shanghai, ,PRC"
            }
        ],
        "venue": "Chinese Health Quality Management",
        "year": 2006
    },
    "yj9pAgEA": {
        "id": "yj9pAgEA",
        "title": "Research on application of essential healthcare technology package",
        "abstract": "One of the main factors influencing the performance of health service is the process of providing service, that is the clinical diagnosis and treatment process, as well as the needed all types of health technologies, including human resource, equipment, facility, medicine, etc. Essential healthcare technology package (EHTP) is an administrative tool for optimizing the clinical diagnosis and treatment process and health technology allocation, through which can implement optimizing intervention on health technology and then promote and improve the performance of service providers. The paper introduces the methodology, technical route and study design of EHTP, as well as the feasibility of its application in quality management for single disease, with the aim to provide evidence-based basis for decision-maker and then invest the limited healthcare technology into the most cost-effective health service project",
        "keywords": [
            "Essential healthcare technology package",
            "Healthcare technology",
            "Performance",
            "Clinical diagnosis and treatment process"
        ],
        "authors": [
            {
                "name": "HUANG Jia-yan",
                "org": ", et al. Hospital Management Department, School of Public Health, Fudan University, Shanghai , China"
            },
            {
                "name": "CHEN Jie",
                "org": ", et al. Hospital Management Department, School of Public Health, Fudan University, Shanghai , China"
            },
            {
                "name": "CHEN Ying-yao",
                "org": ", et al. Hospital Management Department, School of Public Health, Fudan University, Shanghai , China"
            }
        ],
        "venue": "Chinese Journal of Hospital Administration",
        "year": 2006
    },
    "gqVBIJb1": {
        "id": "gqVBIJb1",
        "title": "Study on medical CT allocation and utilization in Shanghai",
        "abstract": "Number of CT scanner and its utilization can be used as an indicator to reflecting the adopting of new medical technology in a region.Through design a horizontal comparative study,this paper concludes that rational allocation of CT in Shanghai and over use existing.By comparison with the norm in UK it had found that there is an unreasonable use of CT in Shanghai,further efforts need be made to improve their utilization management.",
        "keywords": [
            "CT",
            "Medical device",
            "Medical technology"
        ],
        "authors": [
            {
                "name": "YING Xiang-hua",
                "org": "School of Public health,Fudan University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Public health,Fudan University,Shanghai ,China"
            }
        ],
        "venue": "Chinese Health Resources",
        "year": 2008
    },
    "3q6QxlD3": {
        "id": "3q6QxlD3",
        "title": "Cost-effectiveness analysis on periconceptional folic acid supplementation for neural tube defects",
        "abstract": "Objectives:To assess the cost-effectiveness of periconeeptional folio acid supplementation for re- ducing neural tube defects (NTDs) in China.Methods:From the social perspectives,cost effectiveness analysis of supplementation of folio acid is conducted by the decision tree model.Sensitiveness analysis is done to test the robust- ness of the model.Results:In a cohort of 10 000 periconeeptional wowen,the strategy covering all nation (FA2) and the strategy covering both urban and rural in the north and rural in the south (FA4) can avert more NTDs than the strategy covering north only (FA3).Sensitiveness analysis reveals that NTD's incidence,intervention cost and other factors influence strategies'cost effective.Contusions:Periconceptional folio acid supplementation is a cost-effec- tive intervention for preventing neural tube defects,and the strategy covering both north areas and rural areas in the south would better than other strategies in terms of effectiveness and cost-effectiveness",
        "keywords": [
            "Cost-effectiveness analysis",
            "Folic acid",
            "Neural tube defects"
        ],
        "authors": [
            {
                "name": "CHEN Ying-yao",
                "org": "School of Public Health,Fudan University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Public Health,Fudan University,Shanghai ,China"
            },
            {
                "name": "QIAN Xu",
                "org": "School of Public Health,Fudan University,Shanghai ,China"
            },
            {
                "name": "XUE Di",
                "org": "School of Public Health,Fudan University,Shanghai ,China"
            }
        ],
        "venue": "Chinese Health Resources",
        "year": 2007
    },
    "1oT1zxvS": {
        "id": "1oT1zxvS",
        "title": "Study on direct health expenditure of diabetes mellitus in China",
        "abstract": "Objective:To estimate the direct health expenditure of diabetes in China.Methods:Matched case-control method was used to calculate the ratio of direct health expenditure between those with or without diabe- tes.The ratio was then standardized to estimate the national health expenditure on diabetes in 2004.Results:The ratio of annual direct health expenditure between each diabetic and nondiabetic is 2.47.The national health expendi- ture on diabetes is estimated to be 57.47 billion Yuan in 2004,which is about 7.57% of national health expenditure in 2004.Conclusions:The percentage of direct health expenditure on diabetes in national health expenditure is reac- hing that of some developed countries.Effective actions should be taken to reduce economic burden of diabetes.",
        "keywords": [
            "Diabetes mellitus",
            "Direct health expendifure",
            "Case-control"
        ],
        "authors": [
            {
                "name": "ZHANG Zhen-wei",
                "org": "School of Public Health,Fudan University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Public Health,Fudan University,Shanghai ,China"
            },
            {
                "name": "TANG Zhi-liu",
                "org": "School of Public Health,Fudan University,Shanghai ,China"
            },
            {
                "name": "HU Ren-ming",
                "org": "Huashan Hospital,Fudan University,Shanghai ,China"
            },
            {
                "name": "LU Bin",
                "org": "Huashan Hospital,Fudan University,Shanghai ,China"
            }
        ],
        "venue": "Chinese Health Resources",
        "year": 2007
    },
    "lNZNSniQ": {
        "id": "lNZNSniQ",
        "title": "The Comparison of the Regulations of Medical Device Clinical Trials between China and U. S.",
        "abstract": "Clinical trials are essential for ensuring the safety and performance of medical devices,especially high-risk ones.This paper gives a detail comparison of the clinical trail regulations between China and U.S..Through the analysis and comparison,we can see some problems about clinical trial regulation in China and propose some suggestions to improve the administration.",
        "keywords": [
            "Clinical Trial",
            "Comparison and Analysis",
            "Medical Device"
        ],
        "authors": [
            {
                "name": "PAN Erdun",
                "org": ",et al.University of Shanghai for Science and Technology,Shanghai,,China"
            },
            {
                "name": "MI Xianqiang",
                "org": ",et al.University of Shanghai for Science and Technology,Shanghai,,China"
            },
            {
                "name": "CHEN Jie",
                "org": ",et al.University of Shanghai for Science and Technology,Shanghai,,China"
            }
        ],
        "venue": "Chinese Health Quality Management",
        "year": 2009
    },
    "LoH2kxSo": {
        "id": "LoH2kxSo",
        "title": "The considerations on status quo of medical devices management",
        "abstract": "This article analyzed the status quo and problems on medical device management in China.Based on the theoritical progress and global experiences review,it had proposed some suggestions for improving medical device managemnet.",
        "keywords": [
            "Health service",
            "Medical device",
            "Health resourecs"
        ],
        "authors": [
            {
                "name": "MI Xian-qiang",
                "org": "School of Public health,Fudan University,Shanghai ,China;School of Medical Device and Food.Shanghai Science and Engeering University,Shanghai ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Public health,Fudan University,Shanghai ,China"
            },
            {
                "name": "PAN Er-dun",
                "org": "School of Medical Device and Food.Shanghai Science and Engeering University,Shanghai ,China"
            },
            {
                "name": "YU Yong",
                "org": "Shanxi People's Hospital,Shanxi Xian ,China"
            },
            {
                "name": "WANG Cong",
                "org": "School of Medical Device and Food.Shanghai Science and Engeering University,Shanghai ,China"
            }
        ],
        "venue": "Chinese Health Resources",
        "year": 2008
    },
    "ieN2OYJl": {
        "id": "ieN2OYJl",
        "title": "Comparison of Microecological Characterization in Rhizosphere Soil between Healthy and Diseased Plants in Continuous Cropping Potato Fields",
        "abstract": "To explore the microecological mechanism of healthy plant growth in continuous potato fields in Gansu Province,China,we measured contents of available soil nitrogen(NH4+-N),phosphorus(P),and potassium(K)using conventional soil nutrient analytic methods,abundance of soil actinomycetes using serial dilution and plating techniques,and screened antagonistic actinomycetes from obtained actinomycete isolates using the agar block method.The selected dominant actinomycetes were identified by 16S rRNA sequence analysis,and the inhibitory effect of one dominant actinomycete,Streptomyces gancidicus,was tested using culture filtrate.Results showed that in the four-year continuous potato field,available soil P and K contents in the rhizosphere of diseased plants were respectively 29.9% and 12.5% lower than those of healthy plants,whereas soil NH4+-N content in the rhizosphere of diseased plant was 24.1% higher than that of healthy plant.Compared with those from the rhizosphere of healthy plants,the number of soil actinomycetes,Micromonospora,and unidentified actinomycetes from the rhizosphere of diseased plants cultured with the Gause1 medium decreased by 51.1%,83.0%,and 53.9%,respectively,whereas the number of soil actinomycetes and Streptomyces from the rhizosphere of diseased plants cultured with the Humic Acid medium decreased by46.0% and 46.7%,respectively.The soil actinomycetes antagonistic potentiality(SAAP)of actinomycetes with antagonistic effects on the four pathogenic fungi of potato were lower in the rhizosphere of diseased plants than in the rhizosphere of healthy plants.S.gancidicus and S.galilaeus were found dominant in the rhizosphere of healthy and diseased plants,respectively.In conclusion,the microecology of rhizosphere soil that supports healthy plant growth in the continuous potato field is mainly characterized by:available nutrient combination of abundant P and K with relatively poor N contents;and a larger number of soil actinomycetes than those of diseased plants,with the numerically dominant actinomycetes showing beneficial antagonistic effect on several common soil-borne pathogenic fungi.",
        "keywords": [
            "soil nutrient",
            "continuous cropping",
            "microecological mechanism",
            "potato",
            "actinomycetes"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": ""
            },
            {
                "name": "GUO Tian-Wen",
                "org": ""
            },
            {
                "name": "TAN Xue-Lian",
                "org": ""
            },
            {
                "name": "ZHU Wei-Bing",
                "org": ""
            },
            {
                "name": "WEI Xiao-Li",
                "org": ""
            },
            {
                "name": "WANG Dong-Sheng",
                "org": ""
            },
            {
                "name": "XUE Quan-Hong",
                "org": ""
            }
        ],
        "venue": "Acta Agronomica Sinica",
        "year": 2013
    },
    "fVqV8H6t": {
        "id": "fVqV8H6t",
        "title": "Evaluation of CLIGEN precipitation elements on Loess Plateau",
        "abstract": "Among the commonly used stochastic weather generator,CLIGEN is the only one that generates precipitation elements(i.e.precipitation amount,storm duration,time to peak,peak intensity),which will affect the output of hydrological and agricultural response models.Using daily weather data of Changwu weather station from 1957 to 2001,precipitation element data of Wandonggou watershed from 1988 to 2001 and 100 years of CLIGEN generated data,were the ability of the CLIGEN model to reproduce daily,monthly,and(annual) precipitation amounts,probability distribution,extremes,and internal storm patterns(i.e.,storm (duration) and relative peak intensity) were evaluated.Means of daily,monthly,and annual precipitation were(adequately) preserved by CLIGEN and were evaluated absolute relative errors were not more than 1.0%;Standard deviation were all unpredicted and the absolute relative errors were less than 6.6%.Two other probability distributions except daily precipitation were well simulated.Mean absolute relative errors for the all-time maxima of daily,monthly,and yearly precipitation were relatively bigger than corresponding precipitation,suggesting that the ability of predicting extreme need to be improved.The frequencies of wet periods were relatively well replicated by the model,while the frequencies of dry periods less than 20 days have an average relative error of 8.9%.Relative peak intensity generated(ip) by CLIGEN was relatively overestimated than the measured.The CLIGEN-generated durations and precipitation have the similar trend,which were overpredicted for small storms or short duration and underpredicted for large storms or long duration compared with the measured.",
        "keywords": [
            "Loess Plateau",
            "CLIGEN",
            "model evaluation",
            "weather generator",
            "precipitation elements"
        ],
        "authors": [
            {
                "name": "Li Zhi",
                "org": "USDA-ARS Grazinglands Research Laboratory 73036;El Reno;Institute of Soil and Water Conservation,Chinese Academy of Sciences and Ministry of Water Resources,2.College of Resources and Environmental Science,Northwest Sci-Tech University of Agriculture and Forestry: ,Yangling,Shaanxi;Graduate School of the Chinese Academy of Sciences,,Beijing:China"
            },
            {
                "name": "Zhang Xunchang",
                "org": "Oklahoma;USDA-ARS Grazinglands Research Laboratory,73036,El Reno,Oklahoma,USA"
            },
            {
                "name": "Li Shuangjiang",
                "org": "El Reno;Institute of Soil and Water Conservation,Chinese Academy of Sciences and Ministry of Water Resources,2.College of Resources and Environmental Science,Northwest Sci-Tech University of Agriculture and Forestry: ,Yangling,Shaanxi;Graduate School of the Chinese Academy of Sciences,,Beijing:China"
            },
            {
                "name": "Chen Jie",
                "org": "USDA-ARS Grazinglands Research Laboratory 73036"
            }
        ],
        "venue": "Science of Soil and Water Conservation",
        "year": 2006
    },
    "fBZEge9a": {
        "id": "fBZEge9a",
        "title": "Characteristics of precipitation and soil erosive rainfall in Changwu Loess Plateau-gully Region",
        "abstract": "The monthly and annual distribution characteristics of precipitation as well as the probability distribution of annual precipitation were studied,utilizing the daily precipitation from 1957 to 2006,data of which supplied by the Changwu Meteorological Station.The results demonstrate that the distribution of monthly precipitation is variable,and mainly concentrated in July,August,and September.The total annual precipitation varied greatly from year to year.The annual variation of precipitation is larger than the annual variation of rainy days.Analysis of the soil erosive rainfall showed that the highest occurrence of rainfall happened in July and August.The times of rainfall that amounts of rainfall less than 30 mm were more than others.As to single soil erosive rainfall,the rainfall intensity reduced along with the rainfall amount increasing.Meanwhile the times of rainfall duration within 30 min are more than that over 30 min.",
        "keywords": [
            "Loess Plateau-gully Region",
            "precipitation",
            "erosive rainfall"
        ],
        "authors": [
            {
                "name": "Chen Jie",
                "org": "Northwest A & F University,Institute of Soil and water Conservation,CAS & MWR, Yangling,Shaanxi,China"
            },
            {
                "name": "Wang Wenlong",
                "org": "Northwest A & F University,Institute of Soil and water Conservation,CAS & MWR, Yangling,Shaanxi,China"
            },
            {
                "name": "Li Zhi",
                "org": "Northwest A & F University,Institute of Soil and water Conservation,CAS & MWR, Yangling,Shaanxi,China"
            }
        ],
        "venue": "Science of Soil and Water Conservation",
        "year": 2009
    },
    "5WFFsel0": {
        "id": "5WFFsel0",
        "title": "Oligotrophy is Helpful for the Isolation of Bioactive Actinomycetes.",
        "abstract": "It is necessary to develop new methods for the isolation of unknown actinomycetes from soils. To evaluate the effects of oligotrophic medium on the isolation of soil actinomycetes and develop a new isolation method, the Gause's synthetic medium was diluted to one tenth the recommended concentration in the present study. Soil dilution plate technique was used to isolate actinomycetes from the soil samples. Oligotrophy decreased actinomycete and streptomycete counts, as well as the number of antagonistic actinomycete species. Oligotrophy also decreased the number of actinomycete species in five samples. Some actinomycete species were cultured only on the oligotrophic medium, whereas other species could not be cultured. Oligotrophy decreased actinomycete counts more significantly for soils with organic matter content >40 g/kg. We used 16S rRNA sequence analysis to identify 22 actinomycete species that were only cultured on the oligotrophic medium. Oligotrophic medium was helpful for the isolation of Streptomyces spp., Micromonospora spp. and Streptosporangium spp. Slightly more than 80 % of the identified actinomycete species were biologically active. Therefore, we could draw a conclusion that oligotrophic medium could be helpful for the discovery of new antibiotic producers and the exploitation and utilization of new, biologically active compounds.",
        "keywords": [
            "16s rrna",
            "antagonistic actinomycetes",
            "gause\u2019s synthetic medium",
            "taibai mountain"
        ],
        "authors": [
            {
                "name": "Dong-Sheng Wang",
                "org": "College of Natural Resources and Environment, Northwest A&amp;F University, Yangling, Shaanxi China."
            },
            {
                "name": "Quan-Hong Xue",
                "org": "College of Natural Resources and Environment, Northwest A&amp;F University, Yangling, Shaanxi China."
            },
            {
                "name": "Yun-Yan Ma",
                "org": "College of Life Science, Northwest A&amp;F University, Yangling, Shaanxi China."
            },
            {
                "name": "Xiao-Li Wei",
                "org": "College of Natural Resources and Environment, Northwest A&amp;F University, Yangling, Shaanxi China."
            },
            {
                "name": "Jie Chen",
                "org": "College of Natural Resources and Environment, Northwest A&amp;F University, Yangling, Shaanxi China."
            },
            {
                "name": "Fei He",
                "org": "College of Life Science, Northwest A&amp;F University, Yangling, Shaanxi China."
            }
        ],
        "venue": "Indian journal of microbiology",
        "year": 2014
    },
    "vgDl5Luy": {
        "id": "vgDl5Luy",
        "title": "Assessment of CLIGEN non-precipitation parameters on the Loess Plateau",
        "abstract": "Soil erosion models and crop growth simulation models are often used to assess the potential impact of climate variations.Most simulation models require daily weather data,which are frequently synthesized using stochastic daily weather generators.The objective of this study was to evaluate the ability of the CLImate GENerator(CLIGEN) to generate non-precipitation parameters,including daily temperatures,solar radiation,and wind velocity at twelve standard meteorological stations on the Loess Plateau.The results demonstrated that the CLIGEN model reproduced daily maximum temperature reasonably well.In comparison,daily minimum and dew point temperature were less well reproduced,probably because of the range check imposed in the model and used the standard deviation of minimum temperature to compute dew point.Daily solar radiation and wind velocity were less well generated than temperature;especially for wind velocity the generated data were significantly greater than the measured data.Both means and standard deviations of the same day temperature range and one day lag temperature ranges of the CLIGEN-generated data were consistently greater than those of the measured data on all sites.But the means were better reproduced than the standard deviations.Temperature tends to change in a gradual and continuous manner,but CLIGEN generated data did not reproduced this trend.Seasonal serial correlations of maximum and minimum temperatures were well reproduced,but those of solar radiation and cross correlation between temperature and solar radiation were poorly reproduced by the CLIGEN model.There were no day to day correlations for the CLIGEN-generated data,including solar radiation,maximum and minimum temperature.",
        "keywords": [
            "Loess Plateau",
            "CLIGEN",
            "assessment",
            "non-precipitation parameter"
        ],
        "authors": [
            {
                "name": "Chen Jie",
                "org": "USDA-ARS Grazinglands Research Laboratory;College of Nature Resource and Environment,Northwest A & F University;Institute of Soil and Water Conservation,Chinese Academy of Sciences and Ministry of Water Resources:,Yangling,Shaanxi,China"
            },
            {
                "name": "Zhang Xunchang",
                "org": "USDA-ARS Grazinglands Research Laboratory,73036,El Reno,Oklahoma,USA"
            },
            {
                "name": "Li Zhi",
                "org": "USDA-ARS Grazinglands Research Laboratory;College of Nature Resource and Environment,Northwest A & F University;Institute of Soil and Water Conservation,Chinese Academy of Sciences and Ministry of Water Resources:,Yangling,Shaanxi,China"
            }
        ],
        "venue": "Science of Soil and Water Conservation",
        "year": 2007
    },
    "FERD8zmL": {
        "id": "FERD8zmL",
        "title": "Soil and water conservation benefits and suitability of different forestation trees in tableland-gully area of the Loess Plateau",
        "abstract": "\u3010Objective\u3011 Soil and water conservation benefits and suitability of different young afforested trees were evaluated in tableland-gully area of the Loess Plateau.\u3010Method\u3011 The runoff,soil erosion,soil water content and physiological characteristics of,mono-species of R.pseudoacacia,P.tabulaeformis,P.orientalis,H.rhamnoides and their mixtures in vegetated runoff plots were analyzed taking grassland as a control.\u3010Result\u3011 The results demonstrated that in the early stage of afforestation,the benefits of water and soil conservation were relatively poor for all afforested tree species and afforestation methods.The differences of soil erosion amounts between each tree species under monoculture or biculture resulted from differences in vegetation cover.The relationship between soil erosion and vegetation cover could be expressed by a quadratic function.Regression analysis showed that soil erosion was not severe when vegetation cover was more than fifty percent.Soil water content varied with the soil depth within the top 250 cm in grassland and each woodlot,but it became more or less constant below the 250 cm depth.R.pseudoacacia consumed most soil water,followed by P.orientalis,P.tabulaeformis,and H.rhamnoides with the last two being similar to the grassland.There were no significant differences in soil water contents between mono-species and its binary mixtures,except for R.pseudoacacia and its mixtures.Water use efficiency followed the order of:P.orientalis > P.tabulaeformis \u2248H.rhamnoides > R.pseudoacacia.The leaf water use efficiencies of both P.tabulaeformis and H.rhamnoides in the mixture were significantly increased compared to the monocultures.The leaf transpiration rates followed the order of:R.pseudoacacia \u2248H.rhamnoides > P.tabulaeformis > P.orientalis.Compared to their monocultures,the leaf transpiration rates of P.tabulaeformis and R.pseudoacacia decreased in their biculture mixed with H.rhamnoides,while the transpiration rates of H.rhamnoides remained relatively constant.\u3010Conclusion\u3011 Considering soil and water conservation benefits and adaptability of each tree species,we could conclude that the biculture of H.rhamnoides and P.tabulaeformis is very likely suitable for afforestation in tableland-gully areas of the Loess Plateau.",
        "keywords": [
            "soil water content",
            "afforested tree species",
            "tableland-gully area of the Loess Plateau",
            "soil and water conservation benefit",
            "afforestation method"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": " College of Resource and Environment,Northwest A & F University,Yangling,Shaanxi ,China"
            },
            {
                "name": "ZHANG Xun-chang",
                "org": " USDA-ARS Grazinglands Research Laboratory 73036,El Reno,Oklahoma,USA"
            },
            {
                "name": "ZHANG Bei-ying",
                "org": " Institute of Soil and water Conservation,Chinese Academy of Sciences and Ministry of Water Resources,Yangling,Shaanxi ,China"
            },
            {
                "name": "WANG Bing",
                "org": " Institute of Soil and water Conservation,Chinese Academy of Sciences and Ministry of Water Resources,Yangling,Shaanxi ,China"
            },
            {
                "name": "YANG Yu-ling",
                "org": " College of Resource and Environment,Northwest A & F University,Yangling,Shaanxi ,China"
            }
        ],
        "venue": "Journal of Northwest A & F University(Natural Science Edition)",
        "year": 2008
    },
    "iHEbn2EB": {
        "id": "iHEbn2EB",
        "title": "Hydro-ecological effects of woodland in the loess hilly-gullied region",
        "abstract": "Soil and water conservation benefits of different afforested trees in the loess hilly-gullied region were evaluated based on runoff and soil erosion measured in vegetated runoff plots between 1993 and 2002.Soil water conditions and their dynamics under forestation trees were also analyzed according to soil water content measured in 2002.Results showed that runoff and sediment were correlated with rainfall.Multiple regression analysis indicated that there was a positive correlation between runoff and the product of rainfall depth and maximum 0.5-hour rainfall intensity at the significant level of 0.01,as well as between sediment and the product of rainfall depth and maximum 0.5-hour rainfall intensity.However,both runoff and sediment were negatively correlated with vegetation cover.The multiple correlation coefficient ranged from 0.465 to 0.723 for runoff and was 0.253 for sediment.In addition,soil and water conservation benefits were reasonably evident for all afforested trees.Compared with farmland,runoff and sediment decreased to 4.8%-52.9% and 26.8%-86.0%,respectively.The soil and water conservation benefits of Hippophae rhamnoides and its mixtures were greater than those of Pinus tabulaeformis whose cover was poor in the early growth years,during which runoff and sediment were even greater than those of farmland.But the benefits increased as the trees grew.However,the soil and water conservation benefits of Hippophae rhamnoides and its mixtures were good even in the early growing years and became even better as trees grew over time in eleven years.Soil water content below 30 cm soil layer under the Hippophae rhamnoides and its mixtures decreased during the entire growing season,being highest in April and lowest in October.Water consumption depths of the Hippophae rhamnoides under monoculture and biculture were 220 and 300 cm,respectively,in 2002.There were significant differences in soil water content for mono-species of Hippophae rhamnoides and its binary mixtures during the entire growing season.The tree species,in terms of soil water content,ranked in the ascendant order of Hippophae rhamnoides-Populus simonii Carr mixture,Hippophae rhamnoides,and Hippophae rhamnoides-Pinus tabulaeformis mixture.",
        "keywords": [
            "soil water content",
            "woodland",
            "loess hilly-gullied region",
            "soil and water conservation"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": " College of Resources and Environment,Northwest A & F University,Yangling,Shaanxi ,China"
            },
            {
                "name": "ZHANG Xun-Chang",
                "org": "USDA-ARS Grazinglands Research Laboratory El Reno; USDA-ARS Grazinglands Research Laboratory,El Reno,Oklahoma 73036,USA"
            },
            {
                "name": "HOU Xi-Lu",
                "org": " College of Resources and Environment,Northwest A & F University,Yangling,Shaanxi ,China; Institute of Soil and Water Conservation,Chinese Academy of Sciences and Ministry of Water Resources,Yangling,Shaanxi ,China"
            },
            {
                "name": "HU Meng-Jun",
                "org": " College of Geography and Environment Sciences,Northwest Normal University,Lanzhou,Gansu ,China"
            },
            {
                "name": "WANG Bing",
                "org": " Institute of Soil and Water Conservation,Chinese Academy of Sciences and Ministry of Water Resources,Yangling,Shaanxi ,China"
            }
        ],
        "venue": "Acta Ecologica Sinica",
        "year": 2008
    },
    "9nGMALTR": {
        "id": "9nGMALTR",
        "title": "Genetic Analysis and Gene Mapping of Light Brown Spotted Leaf Mutant in Rice",
        "abstract": "A light brown spotted-leaf mutant of rice was isolated from an ethane methyl sulfonate (EMS)- induced IR64 mutant bank. The mutant, designated as lbsl1 (light brown spotted-leaf 1), displayed light brown spot in the whole growth period from the first leaf to the flag leaf under natural summer field conditions. Agronomic traits including plant height, growth duration, number of filled grains per panicle, seed-setting rate and 1000-grain weight of the mutant were significantly affected. Genetic analysis showed that the mutation was controlled by a single recessive gene, tentatively named lbsl1(t), which was mapped to the short arm of chromosome 6. By developing simple sequence repeat (SSR) markers, the gene was finally delimited to an interval of 130 kb between markers RM586 and RM588. The lbsl1(t) gene is likely a novel rice spotted-leaf gene since no other similar genes have been identified near the chromosomal region. The genetic data and recombination populations provided will facilitate further fine-mapping and cloning of the gene.",
        "keywords": [
            "spotted-leaf",
            "molecular marker",
            "leaf color",
            "gene mapping",
            "oryza sativa"
        ],
        "authors": [
            {
                "name": "feng",
                "org": ""
            },
            {
                "name": "baohua",
                "org": ""
            },
            {
                "name": "yang",
                "org": ""
            },
            {
                "name": "shi",
                "org": ""
            },
            {
                "name": "yongfen",
                "org": ""
            },
            {
                "name": "lin",
                "org": ""
            },
            {
                "name": "lu",
                "org": ""
            },
            {
                "name": "chen",
                "org": ""
            },
            {
                "name": "jie",
                "org": ""
            },
            {
                "name": "wei",
                "org": ""
            },
            {
                "name": "yanlin",
                "org": ""
            },
            {
                "name": "hei",
                "org": ""
            },
            {
                "name": "leung",
                "org": ""
            },
            {
                "name": "wu",
                "org": ""
            },
            {
                "name": "jianli",
                "org": ""
            }
        ],
        "venue": "\u6c34\u7a3b\u79d1\u5b66(\u82f1\u6587\u7248)",
        "year": 2013
    },
    "hlBZp0uh": {
        "id": "hlBZp0uh",
        "title": "Construction and Testing of a Primary Microsatellite Database of Major Rice Varieties in China",
        "abstract": "Sixty-three major inbred varieties and parental lines of major F1 hybrids used in the commercial rice production in China were assayed with rice microsatellites screened in a previous study and additional microsatellites on four chromosomes. A set of 24 markers was selected and proposed for its application in the variety identification of rice, which are distributed on all the 12 rice chromosomes with 2 markers on each chromosome. The 63 major varieties and parental lines, as well as 41 major F1 hybrids, were genotyped with the markers. Alleles detected in each line at each marker locus were verified. By matching marker genotypes of corresponding F1, maternal and paternal lines of hybrid rice, high reliability of the maternal lines was verified, data on the paternal lines were modified, and a false hybrid was removed. A database containing genotype data of 103 major rice varieties and parental lines at the 24 marker loci was constructed and analyzed.",
        "keywords": [
            "frequency of polymorphism",
            "rice (oryza sativa)",
            "simple sequence repeat",
            "database",
            "variety identification",
            "polymorphism"
        ],
        "authors": [
            {
                "name": "ying",
                "org": "rice university"
            },
            {
                "name": "jiezheng",
                "org": "rice university"
            },
            {
                "name": "shi",
                "org": "rice university"
            },
            {
                "name": "yongfeng",
                "org": "south china agricultural university"
            },
            {
                "name": "zhiguo",
                "org": "rice university"
            },
            {
                "name": "zeng",
                "org": "rice university"
            },
            {
                "name": "ruizhen",
                "org": "rice university"
            },
            {
                "name": "chen",
                "org": "rice university"
            },
            {
                "name": "jie",
                "org": "rice university"
            },
            {
                "name": "zhu",
                "org": "rice university"
            },
            {
                "name": "zhiwei",
                "org": "rice university"
            },
            {
                "name": "zhuang",
                "org": "rice university"
            },
            {
                "name": "jieyun",
                "org": "rice university"
            }
        ],
        "venue": "\u6c34\u7a3b\u79d1\u5b66(\u82f1\u6587\u7248)",
        "year": 2007
    },
    "DaVzcLye": {
        "id": "DaVzcLye",
        "title": "Identification of QTLs for Yield Traits in the BC_1F_5 Population of Xieqingzao B//Xieqingzao B/Dongxiang Wild Rice",
        "abstract": "A rice population consisting of 202 BC1F5 lines of the interspecies cross Xieqingzao B (Oryza sativa) //Xieqingzao B/Dongxiang wild rice (O. rufipogon) was tested in 2 years at the same trial site. A total of 23 QTLs for yield traits were detected using a linkage map consisting of 149 markers. The numbers of QTLs detected for individual traits were 2 for the number of panicle per plant (NP), 4 for the number of filled grains per panicle (NFGP), 6 for the total number of spikelets per panicle (TNSP), 5 for spikelet fertility (SF), 4 for 1000-grain weight (TGWT) and 2 for grain yield per plant (GYD). Nine of the QTLs had the enhancing alleles from the Dongxiang wild rice, including 2 for NP, 1 for NFGP, 5 for TNSP and 1 for TGWT. Six of them were located in intervals where QTLs for yield traits have been reported in other studies using 9 interspecies populations. The 23 QTLs were distributed in all the 12 rice chromosomes except chromosome 11. Eighteen of the QTLs were located in 8 clusters. The enhancing alleles were from Xieqingzao B in 4 clusters and from the Dongxiang wild rice in 2 clusters, while the allelic direction in the remaining clusters varied for different traits.",
        "keywords": [
            "yield traits",
            "enhancing allele",
            "quantitative trait loci",
            "BC1F5 population",
            "Dongxing wild rice"
        ],
        "authors": [
            {
                "name": "HUANG De-run",
                "org": "Chinese National Center for Rice Improvement, State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou , China"
            },
            {
                "name": "CHEN Jie",
                "org": "Chinese National Center for Rice Improvement, State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou , China"
            },
            {
                "name": "HOU Li-juan",
                "org": "Chinese National Center for Rice Improvement, State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou , China"
            },
            {
                "name": "FAN Ye-yang",
                "org": "Chinese National Center for Rice Improvement, State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou , China"
            },
            {
                "name": "ZHUANG Jie-yun",
                "org": "Chinese National Center for Rice Improvement, State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou , China"
            }
        ],
        "venue": "Journal of Agricultural Biotechnology",
        "year": 2008
    },
    "rzuvqD2N": {
        "id": "rzuvqD2N",
        "title": "Genetic Analysis and Gene Mapping of a Light Brown Spotted Leaf Mutant in Rice",
        "abstract": "A light brown spotted-leaf mutant of rice was isolated from an EMS-induced IR64 mutant bank.The mutant,designated as lbsl1(light brown spotted-leaf 1),displayed light brown spot in the whole growth period from the first leaf to the flag leaf under natural summer field conditions.Agronomic traits including plant height,growth duration,seed-setting rate and 1000-grain weight of the mutant were significantly affected.Genetic analysis showed that the mutation was controlled by a single recessive gene,tentatively termed lbsl1(t),which was mapped to the short arm of chromosome 6.With developed SSR markers,the gene was finally delimited to an interval of 130 kb between markers RM586 and RM588.The lbsl1(t) gene is likely a novel rice spotted-leaf gene since no other similar genes have been identified near the chromosomal region.The genetic data and recombination populations provided will facilitate further fine-mapping and cloning of the gene.",
        "keywords": [
            "rice",
            "molecular marker",
            "spotted-leaf mutant",
            "leaf color",
            "gene mapping"
        ],
        "authors": [
            {
                "name": "FENG Bao-hua",
                "org": " State Key Laboratory of Rice Biology/Chinese National Center for Rice Improvement,China National Rice Research Institute,Hangzhou ,China"
            },
            {
                "name": "YANG Yang",
                "org": " State Key Laboratory of Rice Biology/Chinese National Center for Rice Improvement,China National Rice Research Institute,Hangzhou ,China; College of Life and Environmental Sciences,Hangzhou Normal University,Hangzhou ,China"
            },
            {
                "name": "SHI Yong-feng",
                "org": " State Key Laboratory of Rice Biology/Chinese National Center for Rice Improvement,China National Rice Research Institute,Hangzhou ,China"
            },
            {
                "name": "LIN Lu",
                "org": "College of Life Sciences,Anhui Normal University,Wuhu ,China"
            },
            {
                "name": "CHEN Jie",
                "org": " State Key Laboratory of Rice Biology/Chinese National Center for Rice Improvement,China National Rice Research Institute,Hangzhou ,China"
            },
            {
                "name": "HUANG Qi-na",
                "org": " State Key Laboratory of Rice Biology/Chinese National Center for Rice Improvement,China National Rice Research Institute,Hangzhou ,China"
            },
            {
                "name": "WEI Yan-lin",
                "org": " State Key Laboratory of Rice Biology/Chinese National Center for Rice Improvement,China National Rice Research Institute,Hangzhou ,China; College of Life and Environmental Sciences,Hangzhou Normal University,Hangzhou ,China"
            },
            {
                "name": "WU Jian-li",
                "org": " State Key Laboratory of Rice Biology/Chinese National Center for Rice Improvement,China National Rice Research Institute,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Rice Science",
        "year": 2012
    },
    "V8ax5FMI": {
        "id": "V8ax5FMI",
        "title": "Characterization and genetic analysis of a light- and temperature-sensitive spotted-leaf mutant in rice.",
        "abstract": "A rice spotted-leaf mutant was isolated from an ethane methyl sulfonate (EMS) -induced IR64 mutant bank. The mutant, designated as spl30 (spotted-leaf30), displayed normal green leaf color under shade but exhibited red-brown lesions under natural summer field conditions. Initiation of the lesions was induced by light and the symptom was enhanced at 33 (\u00b0) C relative to 26 (\u00b0) C. Histochemical staining did not show cell death around the red-brown lesions. Chlorophyll contents in the mutant were significantly lower than those of the wild type while the ratio of chlorophyll a/b remained the same, indicating that spl30 was impaired in biosynthesis or degradation of chlorophyll. Disease reaction patterns of the mutant to Xanthomonas oryzae pv. oryzae were largely unchanged to most races tested except for a few strains. Genetic analysis showed that the mutation was controlled by a single recessive gene, tentatively named spl30(t), which co-segregated with RM15380 on chromosome 3, and was delimited to a 94 kb region between RM15380 and RM15383. Spl30(t) is likely a novel rice spotted-leaf gene since no other similar genes have been identified near the chromosomal region. The genetic data and recombination populations provided in this study will enable further fine-mapping and cloning of the gene.",
        "keywords": [
            "gene mapping",
            "photosynthetic pigment",
            "rice",
            "disease resistance",
            "spotted-leaf."
        ],
        "authors": [
            {
                "name": "Qi-Na Huang",
                "org": "State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou, China."
            },
            {
                "name": "Yong-Feng Shi",
                "org": ""
            },
            {
                "name": "Yang Yang",
                "org": ""
            },
            {
                "name": "Bao-Hua Feng",
                "org": ""
            },
            {
                "name": "Yan-Lin Wei",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "Marietta Baraoidan",
                "org": ""
            },
            {
                "name": "Hei Leung",
                "org": ""
            },
            {
                "name": "Jian-Li Wu",
                "org": ""
            }
        ],
        "venue": "Journal of integrative plant biology",
        "year": 2011
    },
    "7WuqgJSo": {
        "id": "7WuqgJSo",
        "title": "Spotted-Leaf Mutants of Rice (Oryza sativa)",
        "abstract": "Many rice spotted-leaf (spl) mutants are ideal sources for understanding the mechanisms involved in blast resistance, bacterial blight resistance and programmed cell death in plants. The genetic controls of 50 spotted-leaf mutants in rice have been characterized and a few spotted-leaf genes have been isolated as well. This article reviews the origin, genetic modes, isolation and characterization of spotted-leaf genes responsible for their phenotypes, and their resistance responses to main rice diseases.",
        "keywords": [
            "disease resistance",
            "gene",
            "spotted-leaf",
            "programmed cell death",
            "mutagenesis",
            "oryza sativa",
            "genetics"
        ],
        "authors": [
            {
                "name": "huang",
                "org": "rice university"
            },
            {
                "name": "qina",
                "org": "rice university"
            },
            {
                "name": "yang",
                "org": "rice university"
            },
            {
                "name": "shi",
                "org": "rice university"
            },
            {
                "name": "yongfeng",
                "org": "rice university"
            },
            {
                "name": "chen",
                "org": "rice university"
            },
            {
                "name": "jie",
                "org": "rice university"
            },
            {
                "name": "wu",
                "org": "rice university"
            },
            {
                "name": "jianli",
                "org": "rice university"
            }
        ],
        "venue": "Rice Science",
        "year": 2010
    },
    "KRa7L50m": {
        "id": "KRa7L50m",
        "title": "Breakdown or Avoidance of Genetic Drag Between Blast Resistance and Spikelet Fertility Based on Genotype Selection Against Heading Date in Rice",
        "abstract": "Previous study showed that genetic drag between a blast resistance gene Pi25(t) and QTLs conditioning spikelet fertility (qSF-6) and number of filled grains per panicle (qNFGP-6) were detected on the short arm of rice chromosome 6. To further verify, a larger population was used for analysis and the results confirmed the genetic drag between the blast resistance and spikelet fertility (SF) but no genetic drag was detected between the blast resistance and number of filled grains per panicle (NFGP). Breakdown or avoidance of the genetic drag could be achieved by selection against the background genotype of a heading-date gene (qHD-7) that resided in the region between RM2 and RM214 on chromosome 7. To further validate, two lines with almost identical genotypes on all chromosomal regions except the Pi25(t) region on chromosome 6 were chosen to develop a new population. The results showed that qSF-6 could be further subdivided into qSF-6-1 and qSF-6-2. When the genotype of RM2-RM214 region was from rice variety Zhong 156, genetic drag between Pi25(t) and SF (qSF-6-2) was detected, and the allele of qSF-6-2 from rice variety Gumei 2 reduced SF. When genotype of the region between RM2-RM214 was from Gumei 2, no genetic drag was detected. The results indicated that genetic drag between the blast resistance and spikelet fertility could be broken down or avoided under a certain background genotype based on the selection against heading-date and provided a marker aided solution for high level of blast resistance and yield breeding in rice and other crops as well.",
        "keywords": [
            "genetic drag",
            "rice (Oryza sativa)",
            "heading date",
            "quantitative trait locus",
            "blast resistance"
        ],
        "authors": [
            {
                "name": "FAN Ye-yang",
                "org": "Chinese National Center for Rice Improvement/State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou , China "
            },
            {
                "name": "CHEN Jie",
                "org": "Chinese National Center for Rice Improvement/State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou , China "
            },
            {
                "name": "SHI Yong-feng",
                "org": "Chinese National Center for Rice Improvement/State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou , China "
            },
            {
                "name": "WU Jian-li",
                "org": "Chinese National Center for Rice Improvement/State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou , China "
            }
        ],
        "venue": "Chinese Journal of Rice Science",
        "year": 2008
    },
    "94fnB1wJ": {
        "id": "94fnB1wJ",
        "title": "Construction and Testing of Primary Microsatellite Database of Major Rice Varieties in China",
        "abstract": "Sixty-three major conventional varieties and parental lines of major F_ 1 hybrids used in the commercial rice production in China were assayed with microsatellite markers screened in a previous study and additional markers on four chromosomes. A set of 24 markers was selected and proposed for its application in the variety identification of rice, which are distributed on all the 12 rice chromosomes with two markers on each chromosome. The 63 major varieties and parental lines, as well as 41 major F_ 1 hybrids, were genotyped with the markers, and alleles detected at each marker locus were verified. By matching marker genotypes of corresponding F_ 1 , maternal and paternal lines of hybrid rice, high reliability of the maternal lines was verified, data on paternal lines were modified, and a false hybrid was removed. A database containing genotype data of 103 major rice varieties and parental lines at the 24 marker loci was constructed and analyzed. The influence of the authenticity of rice materials on the database quality was discussed, and a threshold for microsatellite marker-based variety identification in rice and an approach for authentification of rice materials and genotype data were proposed.",
        "keywords": [
            "frequency of polymorphism",
            "rice (Oryza sativa)",
            "microsatellite marker",
            "database",
            "variety identification"
        ],
        "authors": [
            {
                "name": "ZHUANG Jie-yun",
                "org": " China National Rice Research Institute, Hangzhou , China"
            },
            {
                "name": "SHI Yong-feng",
                "org": " China National Rice Research Institute, Hangzhou , China"
            },
            {
                "name": "YING Jie-zheng",
                "org": " China National Rice Research Institute, Hangzhou , China"
            },
            {
                "name": "E Zhi-guo",
                "org": " China National Rice Research Institute, Hangzhou , China"
            },
            {
                "name": "ZENG Rui-zhen",
                "org": " Guangdong Provincial Key Laboratory of Plant Molecular Breeding, South China Agricultural University, Guangzhou , China"
            },
            {
                "name": "CHEN Jie",
                "org": " China National Rice Research Institute, Hangzhou , China; International Rice Research Institute, DAPO Box 7777, Metro Manila, Philippines"
            },
            {
                "name": "ZHU Zhi-wei",
                "org": " China National Rice Research Institute, Hangzhou , China"
            }
        ],
        "venue": "Chinese Journal of Rice Science",
        "year": 2006
    },
    "q83JgkNn": {
        "id": "q83JgkNn",
        "title": "A Rapid DNA Miniprep Extraction Method for Large-Scale Rice Mutant Screening",
        "abstract": "A high throughput rice DNA mini-preparation method was developed. The method is suitable for large-scale mutant bank screening as well as large mapping populations with characteristics of maintaining relatively high level of DNA purity and concentration. The extracted DNA was tested and suitable for regular PCR amplification (SSR) and TILLING(targeting induced local lesion in genome) analysis.",
        "keywords": [
            "rice",
            "DNA extraction",
            "targeting induced local lesion in genome",
            "polymerase chain reaction"
        ],
        "authors": [
            {
                "name": "QIU Fu-lin",
                "org": "~ 1 Shenyang Agricultural University, Shengyang , China; ~ 2 Chinese National Center for Rice Improvement / State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou , China; ~ 3 Rice Research Institute, Liaoning Academy of Agricultural Sciences, Shenyang , China"
            },
            {
                "name": "WANG He-he",
                "org": " ~ 4 Entomology and Plant Pathology Division, International Rice Research Institute, DAPO P.O. Box 7777, Metro Manila, Philippines"
            },
            {
                "name": "CHEN Jie",
                "org": " ~ 2 Chinese National Center for Rice Improvement / State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou , China"
            },
            {
                "name": "ZHUANG Jie-yun",
                "org": " ~ 2 Chinese National Center for Rice Improvement / State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou , China"
            },
            {
                "name": "CHENG Shi-hua",
                "org": " ~ 2 Chinese National Center for Rice Improvement / State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou , China"
            },
            {
                "name": "WU Jian-li",
                "org": " ~ 2 Chinese National Center for Rice Improvement / State Key Laboratory of Rice Biology, China National Rice Research Institute, Hangzhou , China"
            }
        ],
        "venue": "Chinese Journal of Rice Science",
        "year": 2006
    },
    "zt6NmkcS": {
        "id": "zt6NmkcS",
        "title": "Recent Advances in Research on Spotted-Leaf Mutants of Rice (Oryza sativa)",
        "abstract": "Many rice spotted-leaf mutants are ideal sources for understanding the mechanisms involved in blast resistance,bacterial blight resistance and programmed cell death in plants.The genetic controls of 49 spotted-leaf mutants in rice have been characterized and a few couple of spl/Spl genes have been isolated as well.This article reviews on the origin,genetic modes,isolation and characterization of spotted-leaf genes responsible for their phenotypes,and their resistance responses to main rice diseases.",
        "keywords": [
            "disease resistance",
            "spotted-leaf",
            "rice",
            "programmed cell death",
            "mutagenesis",
            "genes",
            "phenotypes",
            "mutants",
            "blight",
            "apoptosis"
        ],
        "authors": [
            {
                "name": "HUANG Qi-na",
                "org": "State Key Laboratory of Rice Biology/Chinese National Center for Rice Improvement,China National Rice Research Institute, Hangzhou ,China;College of Life and Environmental Sciences,Hangzhou Normal University,Hangzhou ,China"
            },
            {
                "name": "YANG Yang",
                "org": "State Key Laboratory of Rice Biology/Chinese National Center for Rice Improvement,China National Rice Research Institute, Hangzhou ,China;College of Life and Environmental Sciences,Hangzhou Normal University,Hangzhou ,China"
            },
            {
                "name": "SHI Yong-feng",
                "org": "State Key Laboratory of Rice Biology/Chinese National Center for Rice Improvement,China National Rice Research Institute, Hangzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "State Key Laboratory of Rice Biology/Chinese National Center for Rice Improvement,China National Rice Research Institute, Hangzhou ,China"
            },
            {
                "name": "WU Jian-li",
                "org": "State Key Laboratory of Rice Biology/Chinese National Center for Rice Improvement,China National Rice Research Institute, Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Rice Science",
        "year": 2010
    },
    "BlcJGYfe": {
        "id": "BlcJGYfe",
        "title": "Source and Inheritance of within Cultivar Residual Variation Detected in an indica Rice Variety IR64",
        "abstract": "The phenotypically uniform indica rice variety IR64 was chosen for study of the source and inheritance of within cultivar residual variation using a set of SSR markers.Molecular heterogeneity in IR64 was identified on the short arm of chromosome 2 involving at least five SSR loci spanning nearly 30 cM.The SSR variations originated from the parental lines of IR64(IR5657-33-2 /IR2061-465-1-5-5)and were segregating in the selfed bulk seed stock in a Mendelian manner for more than 20 years.This study was one of few examples to verify successfully that within cultivar variations of SSR in morphologically uniform selfing crops came from its parental lines,which has immediate and commercial applications including test of seed purity,varietal fingerprinting,and curation and propagation of germplasm collections.",
        "keywords": [
            "residual variation",
            "rice",
            "simple sequence repeat",
            "heterogeneity"
        ],
        "authors": [
            {
                "name": "WU Jian-li",
                "org": "Chinese National Center for Rice Improvement /State Key Laboratory of Rice Biology,China National Rice Research Institute,Hangzhou ,China;Entomology and Plant Pathology Division,International Rice Research Institute,DAPO BOX 7777,Metro Manila,Philippines"
            },
            {
                "name": "SHI Yong-feng",
                "org": "Chinese National Center for Rice Improvement /State Key Laboratory of Rice Biology,China National Rice Research Institute,Hangzhou ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "Chinese National Center for Rice Improvement /State Key Laboratory of Rice Biology,China National Rice Research Institute,Hangzhou ,China"
            },
            {
                "name": "ZHUANG Jie-yun",
                "org": "Chinese National Center for Rice Improvement /State Key Laboratory of Rice Biology,China National Rice Research Institute,Hangzhou ,China"
            },
            {
                "name": "ZHENG Kang-le",
                "org": "Chinese National Center for Rice Improvement /State Key Laboratory of Rice Biology,China National Rice Research Institute,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Rice Science",
        "year": 2007
    },
    "sZdk9Rk4": {
        "id": "sZdk9Rk4",
        "title": "Source and Inheritance of the Within Cultivar Residual Variation Detected in an indica Variety IR64",
        "abstract": "The phenotypically uniform indica variety IR64 was chosen for study of the source and inheritance of within cultivar residual variation using a set of SSR markers.Residual heterogeneity in IR64 was identified on the short arm of chromosome 2 involving at least 5 SSR loci spanning nearly 30 cM.The SSR variations originated from the parental lines of IR64(IR5657-33-2/IR2061-465-1-5-5)and were segregating in the selfed bulk seed stock in a Mendelian manner for more than 20 years.This study verified that the within cultivar variations of SSR in a morphologically uniform variety IR64 of a selfing crop came from its parental lines,which has immediate and commercial applications including test of hybrid seed purity,varietal fingerprinting,and curation and propagation of germplasm collections.",
        "keywords": [
            "rice",
            "simple sequence repeat",
            "residual heterogeneity",
            "within cultivar variation"
        ],
        "authors": [
            {
                "name": "wu",
                "org": "rice university"
            },
            {
                "name": "jianli",
                "org": "rice university"
            },
            {
                "name": "shi",
                "org": "rice university"
            },
            {
                "name": "yongfeng",
                "org": "international rice research institute"
            },
            {
                "name": "chen",
                "org": "rice university"
            },
            {
                "name": "jie",
                "org": "international rice research institute"
            },
            {
                "name": "casiana",
                "org": "rice university"
            },
            {
                "name": "vera",
                "org": "rice university"
            },
            {
                "name": "cruz",
                "org": "rice university"
            },
            {
                "name": "zhuang",
                "org": "rice university"
            },
            {
                "name": "jieyun",
                "org": "rice university"
            },
            {
                "name": "hei",
                "org": "rice university"
            },
            {
                "name": "leung",
                "org": "rice university"
            },
            {
                "name": "zheng",
                "org": "rice university"
            },
            {
                "name": "kangle",
                "org": "rice university"
            }
        ],
        "venue": "\u6c34\u7a3b\u79d1\u5b66(\u82f1\u6587\u7248)",
        "year": 2007
    },
    "jV9emluh": {
        "id": "jV9emluh",
        "title": "Genetic analysis and gene mapping of a new rolled-leaf mutant in rice (<Emphasis Type=\"Italic\">Oryza sativa</Emphasis> L.)",
        "abstract": "To understand the development of rice leaf blades, we identified a new rolled-leaf mutant, w32, from indica cultivar IR64\n through EMS mutagenesis. The mutant showed a stable rolled-leaf phenotype throughout the life cycle. Two F2 populations were developed by crossing w32 to cultivar IR24 and PA64. Genetic analysis showed that the rolled-leaf phenotype\n was controlled by a single recessive gene. To determine the location of the gene, bulked segregant analysis was carried out\n using mutant and wild-type DNA pools and 1846 mutant-type F2 individuals derived from the cross w32/PA64 were genotyped to locate the gene on the short arm of chromosome 7. The rolled-leaf\n gene, tentatively named rl11(t), is likely a new gene as no other rolled-leaf genes have been identified near the region. By developing new SSR and InDel\n markers, the gene was delimited to a 52 kb region near the end of the short chromosome arm. Further fine mapping and cloning\n of the gene are currently underway.",
        "keywords": [
            "rice (Oryza sativa L.)",
            " chemical mutagenesis",
            " molecular marker",
            " rolled-leaf gene",
            " physical map"
        ],
        "authors": [
            {
                "name": "YongFeng\u00a0Shi",
                "org": "Chinese National Center for Rice Improvement/National key Laboratory for Rice Biology,China National Rice Research Institute,Hangzhou,China"
            },
            {
                "name": "Jie\u00a0Chen",
                "org": "Chinese National Center for Rice Improvement/National key Laboratory for Rice Biology,China National Rice Research Institute,Hangzhou,China"
            },
            {
                "name": "WenQiang\u00a0Liu",
                "org": "Chinese National Center for Rice Improvement/National key Laboratory for Rice Biology,China National Rice Research Institute,Hangzhou,China"
            },
            {
                "name": "QiNa\u00a0Huang",
                "org": "Chinese National Center for Rice Improvement/National key Laboratory for Rice Biology,China National Rice Research Institute,Hangzhou,China"
            },
            {
                "name": "Bo\u00a0Shen",
                "org": "College of Life and Environmental Sciences,Hangzhou Normal University,Hangzhou,China"
            },
            {
                "name": "Hei\u00a0Leung",
                "org": "International Rice Research Institute,Manila,Philippines"
            },
            {
                "name": "JianLi\u00a0Wu",
                "org": "Chinese National Center for Rice Improvement/National key Laboratory for Rice Biology,China National Rice Research Institute,Hangzhou,China"
            }
        ],
        "venue": "Science in China. Series C, Life sciences / Chinese Academy of Sciences",
        "year": 2009
    },
    "Qw6MD7MC": {
        "id": "Qw6MD7MC",
        "title": "Avoidance of Linkage Drag Between Blast Resistance Gene and the QTL Conditioning Spikelet Fertility Based on Genotype Selection Against Heading Date in Rice",
        "abstract": "Previous study showed that a linkage drag between a blast resistance gene Pi25 (t) and QTLs conditioning spikelet fertility ( qSF-6) and number of filled grains per panicle ( qNFGP-6 ) was detected on the short arm of chromosome 6. A larger population was used for further verification, and the results confirmed the linkage drag between the blast resistance gene and QTL conditioning spikelet fertility, other than QTL conditioning number of filled grains per panicle. Breakdown or avoidance of the linkage drag could be achieved by selection against the genotype background of a heading-date gene ( qHD-7 ) that resided in the region between RM2 and RM214 on chromosome 7. For further validation, two lines with almost identical genotypes on all chromosomal regions except the Pi25 (t) region on chromosome 6 were chosen to develop a new population. The results showed that qSF-6 could be further subdivided into qSF-6-1 and qSF-6-2 . When the genotype of the region between RM2 and RM214 was from rice variety Zhong 156, the linkage drag between Pi25 (t) and qSF-6-2 was detected and the allele of qSF-6-2 from rice variety Gumei 2 reduced the spikelet fertility. When the genotype of the region between RM2 and RM214 was from Gumei 2, no linkage drag was detected. This indicates that the linkage drag between the blast resistance gene and the QTL conditioning spikelet fertility could be broken down or avoided under a certain background genotype selection against heading-date and provides a marker aided solution for high level of blast resistance and yield breeding in rice and other crops as well.",
        "keywords": [
            "spikelet fertility",
            "rice ( Oryza sativa )",
            "heading date",
            "linkage drag",
            "quantitative trait locus",
            "blast resistance"
        ],
        "authors": [
            {
                "name": "Wen-qiang LIU",
                "org": "Chinese National Center for Rice Improvement/State Key Laboratory for Rice Biology, China National Rice Research Institute, Hangzhou 310006, China"
            },
            {
                "name": "Ye-yang FAN",
                "org": "Chinese National Center for Rice Improvement/State Key Laboratory for Rice Biology, China National Rice Research Institute, Hangzhou 310006, China"
            },
            {
                "name": "Jie CHEN",
                "org": "Chinese National Center for Rice Improvement/State Key Laboratory for Rice Biology, China National Rice Research Institute, Hangzhou 310006, China"
            },
            {
                "name": "Yong-feng SHI",
                "org": "Chinese National Center for Rice Improvement/State Key Laboratory for Rice Biology, China National Rice Research Institute, Hangzhou 310006, China"
            },
            {
                "name": "Jian-li WU",
                "org": ""
            }
        ],
        "venue": "\u6c34\u7a3b\u79d1\u5b66(\u82f1\u6587\u7248)",
        "year": 2009
    },
    "UG8OlKQ3": {
        "id": "UG8OlKQ3",
        "title": "Superconducting properties of Y\u2013Ba\u2013Cu\u2013O Compounds",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "michael d hurley",
                "org": ""
            },
            {
                "name": "r e soltis",
                "org": ""
            },
            {
                "name": "c j mcewan",
                "org": ""
            },
            {
                "name": "w win",
                "org": ""
            },
            {
                "name": "e m logothetis",
                "org": ""
            },
            {
                "name": "j t chen",
                "org": ""
            },
            {
                "name": "l e wenger",
                "org": ""
            }
        ],
        "venue": "Japanese Journal of Applied Physics",
        "year": 2014
    },
    "drnbmjct": {
        "id": "drnbmjct",
        "title": "Boundary Conditions and Spatial Variations Associated with the Dynamic Modes of Josephson Tunnel Junctions",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "s c meepagala",
                "org": ""
            },
            {
                "name": "jhyjiun chang",
                "org": ""
            },
            {
                "name": "j t chen",
                "org": ""
            }
        ],
        "venue": "Japanese Journal of Applied Physics",
        "year": 1987
    },
    "fGSIzRRb": {
        "id": "fGSIzRRb",
        "title": "Observation of microwave induced dc voltages in a YBa2Cu3O7$minus;$delta; single crystal",
        "abstract": "",
        "keywords": [
            "standing wave",
            "josephson junction",
            "josephson effect",
            "single crystal"
        ],
        "authors": [
            {
                "name": "d c ling",
                "org": ""
            },
            {
                "name": "kevin chang",
                "org": ""
            },
            {
                "name": "jing chen",
                "org": ""
            },
            {
                "name": "l e wenger",
                "org": ""
            }
        ],
        "venue": "Physica C-superconductivity and Its Applications",
        "year": 1994
    },
    "qjZv1jx0": {
        "id": "qjZv1jx0",
        "title": "Interaction between microwaves and a single vortex in a long Josephson tunnel junction",
        "abstract": "",
        "keywords": [
            "dimensions",
            "electromagnetic radiation",
            "length",
            "mathematical model",
            "microwave radiation",
            "mathematical models",
            "interactions",
            "magnetic flux",
            "resonance",
            "josephson junctions",
            "electric currents",
            "currents",
            "josephson junction",
            "tunnel effect"
        ],
        "authors": [
            {
                "name": "m scheuermann",
                "org": "wayne state university"
            },
            {
                "name": "j t chen",
                "org": "wayne state university"
            },
            {
                "name": "jhyjiun chang",
                "org": "wayne state university"
            }
        ],
        "venue": "Journal of Applied Physics",
        "year": 1983
    },
    "ROeltLh3": {
        "id": "ROeltLh3",
        "title": "Ultrathin Au films studied with the scanning tunneling microscope: Topography of insulating surfaces",
        "abstract": "",
        "keywords": [
            "scanning electron microscopy",
            "scanning tunneling microscopy",
            "electron microscope",
            "surface roughness",
            "surface analysis",
            "electric conductivity",
            "thin film",
            "spatial resolution",
            "surface structure",
            "high resolution",
            "scanning tunneling microscope"
        ],
        "authors": [
            {
                "name": "r c jaklevic",
                "org": "ford motor company"
            },
            {
                "name": "larry dean elie",
                "org": "ford motor company"
            },
            {
                "name": "weidian shen",
                "org": "wayne state university"
            },
            {
                "name": "j t chen",
                "org": "wayne state university"
            }
        ],
        "venue": "Applied Physics Letters",
        "year": 1988
    },
    "VdzWwZpG": {
        "id": "VdzWwZpG",
        "title": "Rapid thermal annealing of YBaCuO films on Si and SiO2 substrates",
        "abstract": "",
        "keywords": [
            "high temperature superconductor",
            "thin film",
            "critical temperature"
        ],
        "authors": [
            {
                "name": "m aslam",
                "org": "wayne state university"
            },
            {
                "name": "r e soltis",
                "org": "ford motor company"
            },
            {
                "name": "e m logothetis",
                "org": "ford motor company"
            },
            {
                "name": "r ager",
                "org": "ford motor company"
            },
            {
                "name": "m mikkor",
                "org": "ford motor company"
            },
            {
                "name": "w win",
                "org": "wayne state university"
            },
            {
                "name": "j t chen",
                "org": "wayne state university"
            },
            {
                "name": "l e wenger",
                "org": "wayne state university"
            }
        ],
        "venue": "Applied Physics Letters",
        "year": 1988
    },
    "jlzVOquV": {
        "id": "jlzVOquV",
        "title": "Near room\u2010temperature resistive transitions in single crystals of YBa2Cu3O7\u2212xwith defects",
        "abstract": "",
        "keywords": [
            "room temperature",
            "single crystal",
            "thermal cycling",
            "electric conductivity"
        ],
        "authors": [
            {
                "name": "johnny chen",
                "org": "wayne state university"
            },
            {
                "name": "l e wenger",
                "org": "wayne state university"
            },
            {
                "name": "li zhao qi wang",
                "org": "wayne state university"
            },
            {
                "name": "g h chen",
                "org": "wayne state university"
            }
        ],
        "venue": "",
        "year": 1992
    },
    "3o7sf02v": {
        "id": "3o7sf02v",
        "title": "Laser Processing and Characterization of High-Tc Superconductors",
        "abstract": "",
        "keywords": [
            "surface layer",
            "structured data",
            "high temperature superconductor",
            "raman spectroscopy",
            "raman spectra",
            "crystal structure",
            "x ray diffraction"
        ],
        "authors": [
            {
                "name": "w h weber",
                "org": "ford motor company"
            },
            {
                "name": "e m logothetis",
                "org": "ford motor company"
            },
            {
                "name": "r e soiitis",
                "org": "ford motor company"
            },
            {
                "name": "g w graham",
                "org": "wayne state university"
            },
            {
                "name": "j t chen",
                "org": "wayne state university"
            },
            {
                "name": "l e wenger",
                "org": "wayne state university"
            }
        ],
        "venue": "",
        "year": 1987
    },
    "Sfu9t1QD": {
        "id": "Sfu9t1QD",
        "title": "New Advances in the Study of the Relationship Between Dynamic Externality and Optimization of Industrial Structure",
        "abstract": "Since Marshall proposed the concept of clustering,the research on the relationship between dynamic externality and optimization of industrial structure has been the focus of attention by the academia and practices.This paper attempts to comb the foreign existing literature,exploring the optimization of industrial sturcture from the perspective of MAR externality,Jacobs externality,Porter externality and agglomeration network,which can provide a reference for further study on the dynamic externality and optimization of industrial structure.",
        "keywords": [
            "Jacobs Externality",
            "MAR Externality",
            "Agglomeration Network",
            "Optimization of Industrial Structure",
            "Porter Externality"
        ],
        "authors": [
            {
                "name": "WANG Yao-zhong",
                "org": "School of Economics and Trade,Hunan University,Changsha,Hunan ,Chian;School of Economics and Management,Changsha University of Science and Technology,Changsha,Hunan ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Economics and Trade,Hunan University,Changsha,Hunan ,Chian"
            }
        ],
        "venue": "The Theory and Practice of Finance and Economics",
        "year": 2012
    },
    "peTCSmwL": {
        "id": "peTCSmwL",
        "title": "Constitutes of Mineral Resources Value and Accounting Measurements",
        "abstract": "For a long time,the worthless theory influenced the measurement of mineral resource assets.Mineral enterprises have capitalized the exploration and development costs into mineral resource assets,thus it does not reflect the value of mineral resources reserves.According to the labor value theory,rental theory and utility value theory,the value of mineral resources is divided into intrinsic value and extrinsic value,and bring reserve value into intrinsic value.To enhance the relevance and reliability of the accounting information,measuring the value of mineral resources should combine with the historical cost and fair value measurement.Historical cost method is mainly adopted when measure the extrinsic value of mineral resources while fair value method is applied in measuring the intrinsic value,in order to truly reflect the value of the assets of mineral resources.",
        "keywords": [
            "Value of Mineral Resources",
            "Fair Value",
            "Accounting Measurement"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "College of Accounting,Hunan University;Hunan International Economics University,Changsha,Hunan ,China"
            },
            {
                "name": "GONG Guang-ming",
                "org": "College of Accounting,Hunan University"
            }
        ],
        "venue": "The Theory and Practice of Finance and Economics",
        "year": 2010
    },
    "wHiozJOd": {
        "id": "wHiozJOd",
        "title": "FORECAST OF THE TERTIARY INDUSTRY EMPLOYMENT OF HUNAN PROVINCE\u2014\u2014BASED ON GRAY SYSTEM GM(1,1) MODEL",
        "abstract": "We analyzed the number of 2002-2007 employment in the tertiary industry in Hunan province by gray system GM(1,1)model.The gray system-related tests show that GM(1,1)model error is small and it can be fitted well with the Hunan province of the tertiary industry employment.The prediction has some reference value to the development of tertiary industry employment trends in Hunan province.Using the model,we can predict that the employment in the tertiary industry in Hunan Province is 14.034 million people in 2008,15.122 million people in 2009,16.293 million people in 2010 and 17.556 million people in 2011.",
        "keywords": [
            "employment",
            "tertiary",
            "gray forecast"
        ],
        "authors": [
            {
                "name": "CHEN Jie",
                "org": "School of Economics and Trade,Hunan University,Changsha,Hunan ,China"
            },
            {
                "name": "LI Yu-shuang",
                "org": "School of Economics and Trade,Hunan University,Changsha,Hunan ,China"
            },
            {
                "name": "HAN Feng",
                "org": "School of Economics and Trade,Hunan University,Changsha,Hunan ,China"
            }
        ],
        "venue": "Mathematics in Economics",
        "year": 2009
    },
    "hu0oEzNz": {
        "id": "hu0oEzNz",
        "title": "International Technology Spillover,Independent Innovation and Service Development:Base on Panel VAR in Yangtze River Delta",
        "abstract": "In this paper a Panel VAR model is established using the data from 1997 to 2009 in Yangtze River Delta to estimate the effect of international technology spillover and independent innovation on service development.The results show that international trade technology spillover inhibits service development while foreign direct investment technology spillover,the increase of independent innovation input and the improvement of independent innovation ability promote service development in the long run;international trade technology spillover and the improvement of independent innovation inhibit service development while foreign direct investment technology spillover and the increase of independent innovation input promote service development in the short run.Variance decomposition demonstrates that the effect extent of independent innovation is greater than that of international technology spillover.",
        "keywords": [
            "Yangtze River Delta",
            "Service development",
            "Panel VAR"
        ],
        "authors": [
            {
                "name": "WANG Yao-zhong",
                "org": "School of Economics and Trade,Hunan University,Changsha Hunan ,China;School of Economics and Management,Changsha University of Science and Technology,Changsha Hunan ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Economics and Trade,Hunan University,Changsha Hunan ,China"
            },
            {
                "name": "Zhang Yang",
                "org": "School of Economics and Trade,Hunan University,Changsha Hunan ,China"
            }
        ],
        "venue": "The Theory and Practice of Finance and Economics",
        "year": 2011
    },
    "LTXnYSFv": {
        "id": "LTXnYSFv",
        "title": "Empirical Study on The Impact of China's Inflation on Economic Growth in Marketization Process",
        "abstract": "This is the first time that we bring marketization process into the relationship between inflation and economic growth in the study system.We focus on the impact of marketization process on China's inflation and economic growth.According to the data from 1978 to 2008 in China and using a cross-term of the regression equation and other methods,the research findings show that: since the reform and opening up,the effect of China's inflation on economic growth is changing.With the gradual increase of marketization process,it changes inflation from disadvantages to advantages for economic growth.",
        "keywords": [
            "marketization process",
            "economic growth",
            "inflation"
        ],
        "authors": [
            {
                "name": "LI Yu-shuang",
                "org": "School of Economics and Trade,Hunan University,Changsha ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "School of Economics and Trade,Hunan University,Changsha ,China"
            },
            {
                "name": "ZHAO Xin-hua",
                "org": "School of Economics and Trade,Hunan University,Changsha ,China"
            }
        ],
        "venue": "Science & Technology and Economy",
        "year": 2009
    },
    "wLpYE5PS": {
        "id": "wLpYE5PS",
        "title": "The Impact of FDI on the Safety of China Commercial Service Industry \u2014\u2014Based on the Simultaneous Equations Model",
        "abstract": "With the 2005\uff5e2010 panel data of 30 provinces in China,the paper researches the impact of FDI on the safety of commercial service industry from domestic investment\u3001output and employment in different region by simultaneous equations model . The results show that it produces crowding-out effect to domestic investment and employment,and produces direct crowding-in effect to domestic output in the country and the eastern region;it produces crowding-in effect to domestic investment and output,and produces crowding-out effect to employment in the central region;it produces crowding-out effect to domestic investment,and produces crowding-in effect to output and employment in the western region. In a word,foreign direct investment poses a threat to business services industry security of China to a certain extent,but the effect is different in different perspectives and different regions.",
        "keywords": [
            "Foreign Direct Investment",
            "Crowding-in Effect",
            "Simultaneous Equation",
            "Crowding-out Effect"
        ],
        "authors": [
            {
                "name": "WANG Yao-zhong",
                "org": "College of Economics and Trade,Hunan University,Changsha , China;College of Economics and Management,Changsha University of Science and Technology,Changsha ,China"
            },
            {
                "name": "CHEN Jie",
                "org": "College of Economics and Trade,Hunan University,Changsha , China"
            }
        ],
        "venue": "Economic Survey",
        "year": 2013
    },
    "fnE3YW4t": {
        "id": "fnE3YW4t",
        "title": "Measurement of the Spin of the \u207b Hyperon",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Bernard Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "Marcella Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J.-P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "Vincent Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": "Laboratoire de Physique des Particules, F-74941 Annecy-le-Vieux (France)"
            },
            {
                "name": "E. Grauges",
                "org": "Facultat de Fisica, Departament ECM, Universitat de Barcelona, E-08028 Barcelona (Spain)"
            },
            {
                "name": "A. Palano",
                "org": "Dipartimento di Fisica and INFN, Universita di Bari, I-70126 Bari (Italy)"
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. L. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": "Institute of High Energy Physics, Beijing 100039 (China)"
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": "Institute of Physics, University of Bergen, N-5007 Bergen (Norway)"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2006
    },
    "JUCMy5ux": {
        "id": "JUCMy5ux",
        "title": "Observation of CP Violation in B{yields}{eta}'K{sup 0} Decays",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            },
            {
                "name": "G. S. Abrams",
                "org": ""
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2007
    },
    "T8ZKFhaJ": {
        "id": "T8ZKFhaJ",
        "title": "Dalitz plot analysis of D\u00b0\ufffdK\u00b0K{sup +}K\u207b",
        "abstract": "",
        "keywords": [
            "elementary particles",
            "center of mass"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "NY7f8LNQ": {
        "id": "NY7f8LNQ",
        "title": "Search for the radiative decay B{sup 0}{yields}{phi}{gamma}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges-Pous",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
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                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "nzqjkvQt": {
        "id": "nzqjkvQt",
        "title": "Search for the decay B{sup 0}{yields}K{sub S}{sup 0}K{sub S}{sup 0}K{sub L}{sup 0}",
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        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
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                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
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                "org": ""
            },
            {
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                "org": ""
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            },
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                "org": ""
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                "org": ""
            },
            {
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                "org": ""
            },
            {
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                "org": ""
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            {
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                "org": ""
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            {
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            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
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        ],
        "venue": "Physical Review D",
        "year": 2006
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        "id": "JCO7Itbw",
        "title": "Measurements of CP-Violating Asymmetries in B{sup 0}{yields}a{sub 1}{sup {+-}}(1260){pi}{sup {+-}} Decays",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
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            },
            {
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            {
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                "org": ""
            },
            {
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                "org": ""
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                "org": ""
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            {
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                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
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                "org": ""
            },
            {
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                "org": ""
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            {
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                "org": ""
            },
            {
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                "org": ""
            },
            {
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                "org": ""
            },
            {
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                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
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            },
            {
                "name": "G. S. Abrams",
                "org": ""
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2007
    },
    "iQdRkV8e": {
        "id": "iQdRkV8e",
        "title": "Improved measurements of the branching fractions for B\u00c2\u00b0\u00e2\u00cf{sup +}\u00cf\u00e2\u00bb and B\u00c2\u00b0\u00e2K{sup +}\u00cf\u00e2\u00bb, and a search for B\u00c2\u00b0\u00e2K{sup +}K\u00e2\u00bb",
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        "keywords": [
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            "confidence level"
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        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
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                "org": ""
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            {
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                "org": ""
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            {
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                "org": ""
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            {
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                "org": ""
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            {
                "name": "e grauges",
                "org": "university of barcelona"
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            {
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                "org": ""
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            },
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            {
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                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2007
    },
    "vjUQsseN": {
        "id": "vjUQsseN",
        "title": "Measurements of the B{yields}X{sub s}{gamma} branching fraction and photon spectrum from a sum of exclusive final states",
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        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
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                "org": ""
            },
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                "org": ""
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            {
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                "org": ""
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                "org": ""
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                "org": ""
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            {
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                "org": ""
            },
            {
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                "org": ""
            },
            {
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                "org": ""
            },
            {
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                "org": ""
            },
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                "org": ""
            },
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                "org": ""
            },
            {
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                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
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                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "CBAvQwQ3": {
        "id": "CBAvQwQ3",
        "title": "Search for the charmed pentaquark candidate {theta}{sub c}(3100){sup 0} in e{sup +}e{sup -} annihilations at {radical}(s)=10.58 GeV",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
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            },
            {
                "name": "J. P. Lees",
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            },
            {
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                "org": ""
            },
            {
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                "org": ""
            },
            {
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                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "wh9GTiaR": {
        "id": "wh9GTiaR",
        "title": "Measurements of Branching Fraction, Polarization, and Charge Asymmetry of B{sup {+-}}{yields}{rho}{sup {+-}}{rho}{sup 0} and a Search for B{sup {+-}}{yields}{rho}{sup {+-}}f{sub 0}(980)",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            },
            {
                "name": "G. S. Abrams",
                "org": ""
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2006
    },
    "ZPporXAR": {
        "id": "ZPporXAR",
        "title": "Measurements of Branching Fraction, Polarization, and Charge Asymmetry of B{sup {+-}}\u00e2\u00cf{sup {+-}}\u00cf\u00c2\u00b0 and a Search for B{sup {+-}}\u00e2\u00cf{sup {+-}}f\u00e2(980)",
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        "keywords": [
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            "confidence level"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": "centre national de la recherche scientifique"
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            },
            {
                "name": "g s abrams",
                "org": "lawrence berkeley national laboratory"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2006
    },
    "0dYyWVZl": {
        "id": "0dYyWVZl",
        "title": "Search for Decays of B\u00b0\ufffde{sup +}e\u207b, B\u00b0\ufffd\u03bc{sup +}\u03bc\u207b, B\u00b0\ufffde{sup {+-}}\u03bc{sup {+-}}",
        "abstract": "",
        "keywords": [
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            "elementary particles",
            "confidence level",
            "data collection"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "j m gaillard",
                "org": ""
            },
            {
                "name": "a hicheur",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "guangwei rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2005
    },
    "08YX8Tji": {
        "id": "08YX8Tji",
        "title": "Search for a charged partner of the X(3872) in the B meson decay B\ufffdX\u207bK, X\u207b\ufffdJ/\ufffd\ufffd\u207b\ufffd\u00b0",
        "abstract": "",
        "keywords": [
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            "confidence level",
            "energy storage"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
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            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e graugespous",
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            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
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            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
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            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "zdvJ0Iph": {
        "id": "zdvJ0Iph",
        "title": "Measurement of time-dependent CP asymmetries in B{sup 0}{yields}D{sup (*){+-}}{pi}{sup {+-}} and B{sup 0}{yields}D{sup {+-}}{rho}{sup {+-}} decays",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
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                "org": ""
            },
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                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
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                "org": ""
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            {
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                "org": ""
            },
            {
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                "org": ""
            },
            {
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                "org": ""
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                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "XXjNIc67": {
        "id": "XXjNIc67",
        "title": "Observation of B{yields}{eta}{sup '}K{sup *} and Evidence for B{sup +}{yields}{eta}{sup '}{rho}{sup +}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
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                "name": "R. Barate",
                "org": ""
            },
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                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
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            {
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                "org": ""
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                "name": "V. Poireau",
                "org": ""
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                "org": ""
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            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
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                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
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                "org": ""
            },
            {
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                "org": ""
            },
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                "org": ""
            }
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        "venue": "Physical Review Letters",
        "year": 2007
    },
    "WDd61kBS": {
        "id": "WDd61kBS",
        "title": "Branching fraction limits for B{sup 0} decays to {eta}{sup '}{eta}, {eta}{sup '}{pi}{sup 0} and {eta}{pi}{sup 0}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
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            {
                "name": "V. Poireau",
                "org": ""
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                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "2uRc5WEs": {
        "id": "2uRc5WEs",
        "title": "Observation of Decays B\u00b0\ufffdD{sub s}{sup (*)+}\ufffd\u207b and B\u00b0\ufffdD{sub s}{sup (*)-}K{sup +}",
        "abstract": "",
        "keywords": [
            "standard deviation",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2007
    },
    "X61SqnbN": {
        "id": "X61SqnbN",
        "title": "Improved Measurements of CP-Violating Asymmetry Amplitudes in B{sup 0}{yields}{pi}{sup +}{pi}{sup -} Decays",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges-Pous",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2005
    },
    "e7M10qJU": {
        "id": "e7M10qJU",
        "title": "Measurement of the branching fraction and time-dependent CP asymmetry in the decay B{sup 0}{yields}D*{sup +}D*{sup -}K{sub s}{sup 0}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            },
            {
                "name": "G. S. Abrams",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "zy0yovyU": {
        "id": "zy0yovyU",
        "title": "Dalitz-plot analysis of the decays B{sup {+-}}K{sup {+-}}{sup {+-}}{sup {+-}}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "WAkUs3nI": {
        "id": "WAkUs3nI",
        "title": "Search for B{sup +}\ufffdX(3872)K{sup +}, X(3872)\ufffdJ/\ufffd\u03b3",
        "abstract": "",
        "keywords": [
            "statistical significance",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "6I22RFhX": {
        "id": "6I22RFhX",
        "title": "Measurement of the branching fraction and decay rate asymmetry of B\u00e2\u00bb\u00e2D{sub \u00cf{sup +}}{sub \u00cf\u00e2\u00bb}{sub \u00cf\u00c2\u00b0}K\u00e2\u00bb",
        "abstract": "",
        "keywords": [
            "decay rate",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "guangwei rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "UVjEb4AR": {
        "id": "UVjEb4AR",
        "title": "Measurements of the Absolute Branching Fractions of B{sup {+-}}\ufffdK{sup {+-}}X{sub cc}",
        "abstract": "",
        "keywords": [
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2006
    },
    "NSdTq8yd": {
        "id": "NSdTq8yd",
        "title": "Search for the rare decays B{sup +}\ufffdD{sup (*)+}K{sub S}\u00b0",
        "abstract": "",
        "keywords": [
            "elementary particles",
            "confidence level"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "wUIKJXXa": {
        "id": "wUIKJXXa",
        "title": "Determination of vertical bar V{sub ub} vertical bar from Measurements of the Electron and Neutrino Momenta in Inclusive Semileptonic B Decays",
        "abstract": "",
        "keywords": [
            "elementary particles",
            "standard model"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2005
    },
    "OAh3vOyp": {
        "id": "OAh3vOyp",
        "title": "Observation of a New D{sub s} Meson Decaying to DK at a Mass of 2.86 GeV/c\u00b2",
        "abstract": "",
        "keywords": [
            "center of mass",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "l lopez",
                "org": ""
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2006
    },
    "rQL36t7h": {
        "id": "rQL36t7h",
        "title": "Search for the decay B\u00b0\ufffdK{sub S}\u00b0K{sub S}\u00b0K{sub L}\u00b0",
        "abstract": "",
        "keywords": [
            "elementary particles",
            "confidence level",
            "statistical significance"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "3FYIJedN": {
        "id": "3FYIJedN",
        "title": "Measurement of time-dependent CP asymmetries in B0-->D(*)+/-D+/- decays.",
        "abstract": "We present a first measurement of CP asymmetries in neutral B decays to D+D-, and updated CP asymmetry measurements in decays to D(*+)D- and D(*-)D+. We use fully reconstructed decays collected in a data sample of (232+/-3) x 10(6) gamma(4S)-->BB events in the BABAR detector at the PEP-II asymmetric-energy B Factory at SLAC. We determine the time-dependent asymmetry parameters to be SD(*+)(D-)=-0.54+/-0.35+/-0.07, CD(*+)(D-)=0.09+/-0.25+/-0.06, SD(*-)(D+)=-0.29+/-0.33+/-0.07, CD(*-)(D+)=0.17+/-0.24+/-0.04, SD+(D-)=-0.29+/-0.63+/-0.06, and CD+(D-)=0.11+/-0.35+/-0.06, where in each case the first error is statistical and the second error is systematic.",
        "keywords": [
            "elementary particles"
        ],
        "authors": [
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                "name": "Aubert B",
                "org": "Laboratoire de Physique des Particules, F-74941 Annecy-le-Vieux, France."
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    "99yDnegX": {
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    "rXRso4dx": {
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        "abstract": "",
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    "4mRXHXec": {
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    "aF8AreI1": {
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    "C6lm0kEn": {
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        "title": "Measurement of the B{sup {+-}}{yields}{rho}{sup {+-}}{pi}{sup 0} branching fraction and direct CP asymmetry",
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    "HyiA5l75": {
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        "title": "Search for the decay B{sup +}{yields}{tau}{sup +}{nu}{sub {tau}}",
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    "JKby1eNm": {
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    "ZAmW666c": {
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    "RXJbwIvP": {
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        "title": "Observation of an Excited Charm Baryon \ufffd{sub c}* Decaying to \ufffd{sub c}\u00b0\u03b3",
        "abstract": "",
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            "elementary particles",
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            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": "centre national de la recherche scientifique"
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            },
            {
                "name": "g s abrams",
                "org": "lawrence berkeley national laboratory"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2006
    },
    "htkfiYq9": {
        "id": "htkfiYq9",
        "title": "Measurement of the branching ratios \u00ce\u00b3(D{sub s}*{sup +}\u00e2D{sub s}{sup +}\u00cf\u00c2\u00b0)/\u00ce\u00b3(D{sub s}*{sup +}\u00e2D{sub s}{sup +}\u00ce\u00b3) and \u00ce\u00b3(D*\u00c2\u00b0\u00e2D\u00c2\u00b0\u00cf\u00c2\u00b0)/\u00ce\u00b3(D*\u00c2\u00b0\u00e2D\u00c2\u00b0\u00ce\u00b3)",
        "abstract": "",
        "keywords": [
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
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            },
            {
                "name": "f couderc",
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            },
            {
                "name": "y karyotakis",
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            {
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            {
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            {
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            {
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            {
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            {
                "name": "p l wang",
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            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
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                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
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    },
    "SYbdzro0": {
        "id": "SYbdzro0",
        "title": "Searches for B{sup 0} decays to {eta}K{sup 0}, {eta}{eta}, {eta}{sup '}{eta}{sup '}, {eta}{phi}, and {eta}{sup '}{phi}",
        "abstract": "",
        "keywords": "",
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            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "M. Bona",
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            },
            {
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                "org": ""
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                "org": ""
            },
            {
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                "org": ""
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            },
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            },
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                "name": "A. Zghiche",
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            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
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                "name": "Jie Chen",
                "org": ""
            },
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            },
            {
                "name": "G. Rong",
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            },
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            {
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            },
            {
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            {
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            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "8ZBu7wub": {
        "id": "8ZBu7wub",
        "title": "Search for B meson decays to {eta}{sup '}{eta}{sup '}K",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
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                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
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                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
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                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
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            },
            {
                "name": "P. Wang",
                "org": ""
            },
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                "org": ""
            },
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                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
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            {
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            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "hH7ln2mg": {
        "id": "hH7ln2mg",
        "title": "Exclusive Branching-Fraction Measurements of Semileptonic \u00cf Decays into Three Charged Hadrons, into \u00cf\u00cf\u00e2\u00bb\u00ce\u00bd{sub \u00cf}, and into \u00cfK\u00e2\u00bb\u00ce\u00bd{sub \u00cf}",
        "abstract": "",
        "keywords": [
            "center of mass",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
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                "name": "y karyotakis",
                "org": ""
            },
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            },
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                "name": "v poireau",
                "org": ""
            },
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                "name": "v tisserand",
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            },
            {
                "name": "a zghiche",
                "org": "centre national de la recherche scientifique"
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
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                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            },
            {
                "name": "g s abrams",
                "org": "lawrence berkeley national laboratory"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2008
    },
    "uWciahzX": {
        "id": "uWciahzX",
        "title": "Observation of B{sup +}{yields}{phi}{phi}K{sup +} and Evidence for B{sup 0}{yields}{phi}{phi}K{sup 0} below {eta}{sub c} Threshold",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
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                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            },
            {
                "name": "G. S. Abrams",
                "org": ""
            }
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        "venue": "Physical Review Letters",
        "year": 2006
    },
    "qrqOHOqu": {
        "id": "qrqOHOqu",
        "title": "Measurement of CP Violation Parameters with a Dalitz Plot Analysis of B{sup {+-}}D{sub {sup +}}{sub }{sub \u00b0}K{sup {+-}}",
        "abstract": "",
        "keywords": [
            "decay rate",
            "elementary particles",
            "cp violation",
            "standard deviation"
        ],
        "authors": [
            {
                "name": "b aubert",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
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                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
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                "name": "x prudent",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": "centre national de la recherche scientifique"
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "l lopez",
                "org": ""
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "guangwei rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
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            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2007
    },
    "WhUDgGna": {
        "id": "WhUDgGna",
        "title": "Inclusive \u00ce\u00bb{sub c}{sup +} production in e{sup +}e\u00e2\u00bb annihilations at \u00e2(s)=10.54 GeV and in \u00cf(4S) decays",
        "abstract": "",
        "keywords": [
            "center of mass",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": "centre national de la recherche scientifique"
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
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                "org": ""
            },
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                "org": ""
            },
            {
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                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            },
            {
                "name": "g s abrams",
                "org": "lawrence berkeley national laboratory"
            }
        ],
        "venue": "Physical Review D",
        "year": 2007
    },
    "EtcitEFb": {
        "id": "EtcitEFb",
        "title": "Observation of Decays B{sup 0}{yields}D{sub s}{sup (*)+}{pi}{sup -} and B{sup 0}{yields}D{sub s}{sup (*)-}K{sup +}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
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                "org": ""
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                "org": ""
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                "org": ""
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    },
    "CfM05vdk": {
        "id": "CfM05vdk",
        "title": "Measurement of Branching Fractions and Charge Asymmetries in B{sup +} Decays to {eta}{pi}{sup +}, {eta}K{sup +}, {eta}{rho}{sup +}, and {eta}{sup '}{pi}{sup +}, and Search for B{sup 0} Decays to {eta}K{sup 0} and {eta}{omega}",
        "abstract": "",
        "keywords": "",
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            {
                "name": "B. Aubert",
                "org": ""
            },
            {
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                "org": ""
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                "org": ""
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            {
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                "org": ""
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                "org": ""
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    },
    "qam9LFQE": {
        "id": "qam9LFQE",
        "title": "Measurement of the Branching Fraction and Photon Energy Moments of B{yields}X{sub s}{gamma} and A{sub CP}(B{yields}X{sub s+d}{gamma})",
        "abstract": "",
        "keywords": "",
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            {
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                "org": ""
            },
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                "org": ""
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                "org": ""
            },
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                "org": ""
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                "org": ""
            },
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                "org": ""
            },
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                "org": ""
            },
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                "org": ""
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                "org": ""
            },
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                "org": ""
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        "year": 2006
    },
    "KPjozoPC": {
        "id": "KPjozoPC",
        "title": "Measurement of double charmonium production in e{sup +}e\u207b annihilations at \ufffd(s)=10.6 GeV",
        "abstract": "",
        "keywords": [
            "data collection",
            "center of mass",
            "elementary particles"
        ],
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            {
                "name": "bernard aubert",
                "org": ""
            },
            {
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                "org": ""
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                "org": ""
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                "org": ""
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            },
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                "org": ""
            },
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                "org": ""
            },
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                "org": ""
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                "org": ""
            },
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            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "2wtzIWUF": {
        "id": "2wtzIWUF",
        "title": "Search for the decay {tau}{sup -}{yields}3{pi}{sup -}2{pi}{sup +}2{pi}{sup 0}{nu}{sub {tau}}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "oDOtLNgt": {
        "id": "oDOtLNgt",
        "title": "Measurement of B\u00b0\ufffdD{sup (*)0}K{sup (*)0} branching fractions",
        "abstract": "",
        "keywords": [
            "elementary particles",
            "confidence level"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "VAj3fCAL": {
        "id": "VAj3fCAL",
        "title": "Structure at 2175 MeV in e{sup +}e{sup -}{yields}{phi}f{sub 0}(980) observed via initial-state radiation",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            },
            {
                "name": "G. S. Abrams",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "lIr1iPz6": {
        "id": "lIr1iPz6",
        "title": "Search for the W-exchange decays B\u00b0\ufffdD{sub s}{sup (*)-}D{sub s}{sup (*)+}",
        "abstract": "",
        "keywords": [
            "elementary particles",
            "confidence level",
            "upper bound"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "FY839XiB": {
        "id": "FY839XiB",
        "title": "Improved measurements of the branching fractions for B{sup 0}{yields}{pi}{sup +}{pi}{sup -} and B{sup 0}{yields}K{sup +}{pi}{sup -}, and a search for B{sup 0}{yields}K{sup +}K{sup -}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2007
    },
    "QkpzXce7": {
        "id": "QkpzXce7",
        "title": "Observation of e{sup +}e{sup -} Annihilation into the C=+1 Hadronic Final States {rho}{sup 0}{rho}{sup 0} and {phi}{rho}{sup 0}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2006
    },
    "l4hg3kKu": {
        "id": "l4hg3kKu",
        "title": "Search for Lepton-Flavor and Lepton-Number Violation in the Decay {tau}{sup -}{yields}l{sup {+-}}h{sup {+-}}h{sup '-}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2005
    },
    "DrO6HySN": {
        "id": "DrO6HySN",
        "title": "Search for Lepton Flavor Violating Decays {tau}{sup {+-}}{yields}l{sup {+-}}{pi}{sup 0}, l{sup {+-}}{eta}, l{sup {+-}}{eta}{sup '}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            },
            {
                "name": "G. S. Abrams",
                "org": ""
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2007
    },
    "3BsZPHBg": {
        "id": "3BsZPHBg",
        "title": "Measurement of the B\u207b\ufffdD\u00b0K*\u207b branching fraction",
        "abstract": "",
        "keywords": [
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "vzUG7WEx": {
        "id": "vzUG7WEx",
        "title": "Measurements of Branching Fractions, Polarizations, and Direct CP-Violation Asymmetries in B\u2192\u03c1K* and B\u2192f0(980)K* Decays",
        "abstract": "We present measurements of the branching fractions, longitudinal\npolarization, and direct CP-violation asymmetries for the decays B+ -> rho0 K*+\nand B+ -> f0(980) K*+ with a sample of 467+/-5 million BBbar pairs collected\nwith the BaBar detector at the PEP-II asymmetric-energy e^+e^- collider at the\nSLAC National Accelerator Laboratory. We observe B+ -> rho0 K*+ with a\nsignificance of 5.3 sigma and measure the branching fraction Br(B+ -> rho0 K*+)\n= (4.6+/-1.0+/-0.4) x 10^{-6}, the longitudinal polarization fL =\n0.78+/-0.12+/-0.03, and the CP-violation asymmetry ACP = 0.31+/-0.13+/-0.03. We\nobserve B+ -> f0(980) K*+ and measure the branching fraction Br(B+ -> f0(980)\nK*+) x Br(f0(980) -> pi+pi-) = (4.2+/-0.6+/-0.3) x 10^{-6} and the CP-violation\nasymmetry ACP = -0.15+/-0.12+/-0.03. The first uncertainty quoted is\nstatistical and the second is systematic.",
        "keywords": [
            "elementary particles",
            "cp violation",
            "confidence level"
        ],
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "J. C. Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            },
            {
                "name": "G. S. Abrams",
                "org": ""
            },
            {
                "name": "M. Battaglia",
                "org": ""
            },
            {
                "name": "D. N. Brown",
                "org": ""
            },
            {
                "name": "J. Button-Shafer",
                "org": ""
            },
            {
                "name": "R. N. Cahn",
                "org": ""
            },
            {
                "name": "E. Charles",
                "org": ""
            },
            {
                "name": "M. S. Gill",
                "org": ""
            },
            {
                "name": "Y. Groysman",
                "org": ""
            },
            {
                "name": "R. G. Jacobsen",
                "org": ""
            },
            {
                "name": "J. A. Kadyk",
                "org": ""
            },
            {
                "name": "L. T. Kerth",
                "org": ""
            },
            {
                "name": "Yu. Kolomensky",
                "org": ""
            },
            {
                "name": "G. Kukartsev",
                "org": ""
            },
            {
                "name": "G. Lynch",
                "org": ""
            },
            {
                "name": "L. M. Mir",
                "org": ""
            },
            {
                "name": "T. J. Orimoto",
                "org": ""
            },
            {
                "name": "M. Pripstein",
                "org": ""
            },
            {
                "name": "N. A. Roe",
                "org": ""
            },
            {
                "name": "M. T. Ronan",
                "org": ""
            },
            {
                "name": "W. A. Wenzel",
                "org": ""
            },
            {
                "name": "P. del Amo Sanchez",
                "org": ""
            },
            {
                "name": "M. Barrett",
                "org": ""
            },
            {
                "name": "K. E. Ford",
                "org": ""
            },
            {
                "name": "T. J. Harrison",
                "org": ""
            },
            {
                "name": "A. J. Hart",
                "org": ""
            },
            {
                "name": "C. M. Hawkes",
                "org": ""
            },
            {
                "name": "S. E. Morgan",
                "org": ""
            },
            {
                "name": "A. T. Watson",
                "org": ""
            },
            {
                "name": "T. Held",
                "org": ""
            },
            {
                "name": "H. Koch",
                "org": ""
            },
            {
                "name": "B. Lewandowski",
                "org": ""
            },
            {
                "name": "M. Pelizaeus",
                "org": ""
            },
            {
                "name": "K. Peters",
                "org": ""
            },
            {
                "name": "T. Schroeder",
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        "abstract": "",
        "keywords": [
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            "cp violation"
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        "keywords": "",
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                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "GUQR0CnV": {
        "id": "GUQR0CnV",
        "title": "Evidence for the Rare Decay B{sup +}{yields}D{sub s}{sup +}{pi}{sup 0}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "X. Prudent",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            },
            {
                "name": "G. S. Abrams",
                "org": ""
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2007
    },
    "V8CtekET": {
        "id": "V8CtekET",
        "title": "Search for rare quark-annihilation decays, B\u207b\ufffdD{sub s}{sup (*)-}\ufffd",
        "abstract": "",
        "keywords": [
            "standard model",
            "confidence level",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "M0s07Olz": {
        "id": "M0s07Olz",
        "title": "Study of B{yields}D{sup (*)}D{sub s(J)}{sup (*)} decays and measurement of D{sub s}{sup -} and D{sub sJ}(2460){sup -} branching fractions",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "LJz8FtiQ": {
        "id": "LJz8FtiQ",
        "title": "Search for Factorization-Suppressed B\ufffd\ufffd{sub c}K{sup (*)} Decays",
        "abstract": "",
        "keywords": [
            "elementary particles",
            "gamma radiation",
            "upper bound"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e graugespous",
                "org": ""
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "guangwei rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2005
    },
    "UY30SvnQ": {
        "id": "UY30SvnQ",
        "title": "Search for Factorization-Suppressed B{yields}{chi}{sub c}K{sup (*)} Decays",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges-Pous",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2005
    },
    "Zh4tk4Dy": {
        "id": "Zh4tk4Dy",
        "title": "Measurement of B{sup 0}{yields}D{sup (*)0}K{sup (*)0} branching fractions",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "RRF8JpNt": {
        "id": "RRF8JpNt",
        "title": "Measurement of the B\u00b0\ufffdD*\u207bD{sub s}*{sup +} and D{sub s}{sup +}\ufffd\ufffd\ufffd{sup +} branching fractions",
        "abstract": "",
        "keywords": [
            "elementary particles",
            "quark model"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e graugespous",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "OLCvF8Or": {
        "id": "OLCvF8Or",
        "title": "Measurement of the branching fraction and time-dependent CP asymmetry in the decay B\u00c2\u00b0\u00e2D*{sup +}D*\u00e2\u00bbK{sub s}\u00c2\u00b0",
        "abstract": "",
        "keywords": [
            "elementary particles",
            "confidence level"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": "centre national de la recherche scientifique"
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            },
            {
                "name": "g s abrams",
                "org": "lawrence berkeley national laboratory"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "Gxlpkaeq": {
        "id": "Gxlpkaeq",
        "title": "Study of B to pi ell nu and B to rho ell nu Decays and Determination of |V_ub|",
        "abstract": "",
        "keywords": [
            "quantum mechanics",
            "quantum chromodynamics",
            "form factor",
            "lattice qcd",
            "elementary particles",
            "momentum transfer"
        ],
        "authors": [
            {
                "name": "b aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": ""
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": ""
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "yypLqHR5": {
        "id": "yypLqHR5",
        "title": "Measurement of Branching Fractions and Resonance Contributions for B\u00c2\u00b0\u00e2D\u00c2\u00b0K{sup +}\u00cf\u00e2\u00bb and Search for B\u00c2\u00b0\u00e2D\u00c2\u00b0K{sup +}\u00cf\u00e2\u00bb Decays",
        "abstract": "",
        "keywords": [
            "elementary particles",
            "confidence level"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "guangwei rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2006
    },
    "QQQ7nRuM": {
        "id": "QQQ7nRuM",
        "title": "Search for the decay {tau}{sup -}{yields}4{pi}{sup -}3{pi}{sup +}({pi}{sup 0}){nu}{sub {tau}}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "gy3UDYSk": {
        "id": "gy3UDYSk",
        "title": "Observation of \ufffd(4S) Decays to \ufffd{sup +}\ufffd\u207b\ufffd(1S) and \ufffd{sup +}\ufffd\u207b\ufffd(2S)",
        "abstract": "",
        "keywords": [
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2006
    },
    "biNTYfRb": {
        "id": "biNTYfRb",
        "title": "Measurement of CP observables for the decays B{sup {+-}}{yields}D{sub CP}{sup 0}K{sup {+-}}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "QJiu0USG": {
        "id": "QJiu0USG",
        "title": "Measurement of Branching Fractions and CP -Violating Charge Asymmetries for B Meson Decays to D (\ufffd) D (\ufffd) , and Implications for the CKM Angle",
        "abstract": "",
        "keywords": [
            "elementary particles"
        ],
        "authors": [
            {
                "name": "b aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": ""
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": ""
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "CAnPOUVD": {
        "id": "CAnPOUVD",
        "title": "Search for the rare decays B{sup +}D{sup (*)+}K{sub S}\u00b0",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Bernard Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J.-P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": "Laboratoire de Physique des Particules, F-74941 Annecy-le-Vieux (France)"
            },
            {
                "name": "E. Grauges",
                "org": "IFAE, Universitat Autonoma de Barcelona, E-08193 Bellaterra, Barcelona (Spain)"
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "Alexis Pompili",
                "org": "Universita di Bari, Dipartimento di Fisica, Italy and INFN, I-70126 Bari (Italy)"
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. L. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": "Institute of High Energy Physics, Beijing 100039 (China)"
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": "University of Bergen, Inst. of Physics, N-5007 Bergen (Norway)] [and others"
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "X0RHf2XC": {
        "id": "X0RHf2XC",
        "title": "Measurements of the decays B\u00b0\ufffdD\u00b0pp, B\u00b0\ufffdD*\u00b0pp, B\u00b0\ufffdD\u207bpp\ufffd{sup +}, and B\u00b0\ufffdD*\u207bpp\ufffd{sup +}",
        "abstract": "",
        "keywords": [
            "phase space",
            "mass spectra",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "W9vTpr1D": {
        "id": "W9vTpr1D",
        "title": "Search for Lepton Flavor Violation in the Decay \ufffd{sup {+-}}\ufffd\u03bc{sup {+-}}\u03b3",
        "abstract": "",
        "keywords": [
            "data collection",
            "center of mass",
            "confidence level",
            "conservation law",
            "gamma radiation",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": "institute of high energy physics"
            },
            {
                "name": "y s zhu",
                "org": ""
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2005
    },
    "aO9r5r3q": {
        "id": "aO9r5r3q",
        "title": "Measurement of Branching Fractions and Resonance Contributions for B{sup 0}{yields}D{sup 0}K{sup +}{pi}{sup -} and Search for B{sup 0}{yields}D{sup 0}K{sup +}{pi}{sup -} Decays",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2006
    },
    "MTftffoP": {
        "id": "MTftffoP",
        "title": "Vector-Tensor and Vector-Vector Decay Amplitude Analysis of B{sup 0}{yields}{phi}K{sup *0}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            },
            {
                "name": "G. S. Abrams",
                "org": ""
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2007
    },
    "fFW7B5OI": {
        "id": "fFW7B5OI",
        "title": "Measurement of the branching fraction and the CP-violating asymmetry for the decay B\u00c2\u00b0\u00e2K{sub S}\u00c2\u00b0\u00cf\u00c2\u00b0",
        "abstract": "",
        "keywords": [
            "cp violation",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e graugespous",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "xGLGWCDn": {
        "id": "xGLGWCDn",
        "title": "Evidence of a Broad Structure at an Invariant Mass of 4.32 GeV/c{sup 2} in the Reaction e{sup +}e{sup -}{yields}{pi}{sup +}{pi}{sup -}{psi}(2S) Measured at BABAR",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2007
    },
    "jyRpKLUo": {
        "id": "jyRpKLUo",
        "title": "Measurement of the ratio B(B\u00e2\u00bb\u00e2D\u00c2\u00b0K\u00e2\u00bb)/B(B\u00e2\u00bb\u00e2D\u00c2\u00b0\u00cf\u00e2\u00bb) and of the CP asymmetry of B\u00e2\u00bb\u00e2D{sub CP+}\u00c2\u00b0K\u00e2\u00bb decays",
        "abstract": "",
        "keywords": [
            "decay rate",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e graugespous",
                "org": ""
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "6i0enFnP": {
        "id": "6i0enFnP",
        "title": "Measurement of the Pseudoscalar Decay Constant f{sub D{sub s}} Using Charm-Tagged Events in e{sup +}e\u00e2\u00bb Collisions at \u00e2(s)=10.58 GeV",
        "abstract": "",
        "keywords": [
            "data collection",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
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    "1F7ilQnA": {
        "id": "1F7ilQnA",
        "title": "Dalitz-plot analysis of the decays B{sup {+-}}{yields}K{sup {+-}}{pi}{sup {+-}}{pi}{sup {+-}}",
        "abstract": "",
        "keywords": "",
        "authors": [
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            },
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                "org": ""
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            },
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        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "vLPDHMrj": {
        "id": "vLPDHMrj",
        "title": "Measurements of {lambda}{sub c}{sup +} branching fractions of Cabibbo-suppressed decay modes involving {lambda} and {sigma}{sup 0}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
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            {
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            {
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            }
        ],
        "venue": "Physical Review D",
        "year": 2007
    },
    "6WCNWYyh": {
        "id": "6WCNWYyh",
        "title": "Measurement of the CP Asymmetry and Branching Fraction of B{sup 0}{yields}{rho}{sup 0}K{sup 0}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
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                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
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                "org": ""
            },
            {
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                "org": ""
            },
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                "org": ""
            },
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            },
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                "name": "E. Grauges",
                "org": ""
            },
            {
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                "org": ""
            },
            {
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                "org": ""
            },
            {
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                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
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                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
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                "org": ""
            },
            {
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                "org": ""
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2007
    },
    "FsKu4aUn": {
        "id": "FsKu4aUn",
        "title": "Dalitz plot analysis of D{sup 0}{yields}K{sup 0}K{sup +}K{sup -}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
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            },
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            },
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                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
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                "name": "M. Pappagallo",
                "org": ""
            },
            {
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                "org": ""
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            {
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                "org": ""
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            {
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            },
            {
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            {
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            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
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            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "cZpyPKYE": {
        "id": "cZpyPKYE",
        "title": "Branching fraction measurements of charged B decays to K*{sup +}K{sup +}K{sup -}, K*{sup +}{pi}{sup +}K{sup -}, K*{sup +}K{sup +}{pi}{sup -} and K*{sup +}{pi}{sup +}{pi}{sup -} final states",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
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                "org": ""
            },
            {
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                "org": ""
            },
            {
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                "org": ""
            },
            {
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                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
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                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "SF4hibwy": {
        "id": "SF4hibwy",
        "title": "Observation of a New D{sub s} Meson Decaying to DK at a Mass of 2.86 GeV/c{sup 2}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
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                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2006
    },
    "29fQwboj": {
        "id": "29fQwboj",
        "title": "B meson decays to \ufffdK*, \ufffd\u03c1, \ufffd\ufffd, \ufffd\ufffd, and \ufffdf\ufffd",
        "abstract": "",
        "keywords": [
            "confidence level",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "SlNwYSWM": {
        "id": "SlNwYSWM",
        "title": "Study of the X(3872) and Y(4260) in B{sup 0}{yields}J/{psi}{pi}{sup +}{pi}{sup -}K{sup 0} and B{sup -}{yields}J/{psi}{pi}{sup +}{pi}{sup -}K{sup -} decays",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "MBwShhyu": {
        "id": "MBwShhyu",
        "title": "Observation of the exclusive reaction e{sup +}e\u207b\ufffd\ufffd\u03b7 at \ufffd(s)=10.58 GeV",
        "abstract": "",
        "keywords": [
            "center of mass",
            "elementary particles",
            "cross section"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "x prudent",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": "centre national de la recherche scientifique"
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            },
            {
                "name": "g s abrams",
                "org": "lawrence berkeley national laboratory"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "ok5LQQjE": {
        "id": "ok5LQQjE",
        "title": "Measurement of the Branching Fraction and Photon Energy Moments of B\u00e2X{sub s}\u00ce\u00b3 and A{sub CP}(B\u00e2X{sub s+d}\u00ce\u00b3)",
        "abstract": "",
        "keywords": [
            "spectrum",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2006
    },
    "R63sb4H9": {
        "id": "R63sb4H9",
        "title": "Precise branching ratio measurements of the decays D\u00c2\u00b0\u00e2\u00cf\u00e2\u00bb\u00cf{sup +}\u00cf\u00c2\u00b0 and D\u00c2\u00b0\u00e2K\u00e2\u00bbK{sup +}\u00cf\u00c2\u00b0 relative to the D\u00c2\u00b0\u00e2K\u00e2\u00bb\u00cf{sup +}\u00cf\u00c2\u00b0 decay",
        "abstract": "",
        "keywords": [
            "elementary particles",
            "three body problem"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "guangwei rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "oB0hJFTN": {
        "id": "oB0hJFTN",
        "title": "Measurements of the Absolute Branching Fractions of B{sup {+-}}{yields}K{sup {+-}}X{sub cc}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2006
    },
    "gHNbUW3X": {
        "id": "gHNbUW3X",
        "title": "Measurement of the ratio B(B{sup -}{yields}D{sup 0}K{sup -})/B(B{sup -}{yields}D{sup 0}{pi}{sup -}) and of the CP asymmetry of B{sup -}{yields}D{sub CP+}{sup 0}K{sup -} decays",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges-Pous",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "ayISmzLw": {
        "id": "ayISmzLw",
        "title": "Evidence for B{sup 0}{yields}{rho}{sup 0}{rho}{sup 0} Decays and Implications for the Cabibbo-Kobayashi-Maskawa Angle {alpha}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "X. Prudent",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            },
            {
                "name": "G. S. Abrams",
                "org": ""
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2007
    },
    "rNW8fVQZ": {
        "id": "rNW8fVQZ",
        "title": "Search for the reactions e{sup +}e{sup -}{yields}{mu}{sup +}{tau}{sup -} and e{sup +}e{sup -}{yields}e{sup +}{tau}{sup -}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            },
            {
                "name": "G. S. Abrams",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2007
    },
    "0bMdVLgL": {
        "id": "0bMdVLgL",
        "title": "Measurement of Branching Fractions and Charge Asymmetries in B{sup +} Decays to \u00ce\u00b7\u00cf{sup +}, \u00ce\u00b7K{sup +}, \u00ce\u00b7\u00cf{sup +}, and \u00ce\u00b7{sup '}\u00cf{sup +}, and Search for B\u00c2\u00b0 Decays to \u00ce\u00b7K\u00c2\u00b0 and \u00ce\u00b7\u00cf",
        "abstract": "",
        "keywords": [
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e graugespous",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2005
    },
    "WPIdyZaO": {
        "id": "WPIdyZaO",
        "title": "Search for the decay B\u00b0\ufffdJ/\ufffd\u03b3",
        "abstract": "",
        "keywords": [
            "confidence level",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "j m gaillard",
                "org": ""
            },
            {
                "name": "a hicheur",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2004
    },
    "Obx1klWT": {
        "id": "Obx1klWT",
        "title": "Observation of B\ufffd\u03b7{sup '}K{sup *} and Evidence for B{sup +}\ufffd\u03b7{sup '}\u03c1{sup +}",
        "abstract": "",
        "keywords": [
            "elementary particles",
            "confidence level"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "guangwei rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2007
    },
    "uWyUXrph": {
        "id": "uWyUXrph",
        "title": "Measurements of neutral B decay branching fractions to K{sub S}{sup 0}{pi}{sup +}{pi}{sup -} final states and the charge asymmetry of B{sup 0}{yields}K*{sup +}{pi}{sup -}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "ZNFnthKd": {
        "id": "ZNFnthKd",
        "title": "Measurement of CP asymmetry in B{sup 0}{yields}K{sub s}{sup 0}{pi}{sup 0}{pi}{sup 0} decays",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "X. Prudent",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            },
            {
                "name": "G. S. Abrams",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2007
    },
    "bn8x471P": {
        "id": "bn8x471P",
        "title": "Search for the rare decays B{sup 0}{yields}D{sub s}{sup (*)+}a{sub 0(2)}{sup -}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "4j32RRoM": {
        "id": "4j32RRoM",
        "title": "Search for a charged partner of the X(3872) in the B meson decay B{yields}X{sup -}K, X{sup -}{yields}J/{psi}{pi}{sup -}{pi}{sup 0}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges-Pous",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "9Lkn1rPc": {
        "id": "9Lkn1rPc",
        "title": "Measurement of CP observables for the decays B{sup {+-}}\ufffdD{sub CP}\u00b0K*{sup {+-}}",
        "abstract": "",
        "keywords": [
            "eigenvalues",
            "elementary particles",
            "conservation law"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "HwpglNS1": {
        "id": "HwpglNS1",
        "title": "Search for Decays of B{sup 0}{yields}e{sup +}e{sup -}, B{sup 0}{yields}{mu}{sup +}{mu}{sup -}, B{sup 0}{yields}e{sup {+-}}{mu}{sup {+-}}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "J.M. Gaillard",
                "org": ""
            },
            {
                "name": "A. Hicheur",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
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                "org": ""
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            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            },
            {
                "name": "g s abrams",
                "org": "lawrence berkeley national laboratory"
            }
        ],
        "venue": "Physical Review D",
        "year": 2007
    },
    "ajDumws0": {
        "id": "ajDumws0",
        "title": "Study of B\u00e2D{sup (*)}D{sub s(J)}{sup (*)} decays and measurement of D{sub s}\u00e2\u00bb and D{sub sJ}(2460)\u00e2\u00bb branching fractions",
        "abstract": "",
        "keywords": [
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "svUxkiyC": {
        "id": "svUxkiyC",
        "title": "Branching Fractions and CP Asymmetries in B\u00c2\u00b0\u00e2\u00cf\u00c2\u00b0\u00cf\u00c2\u00b0, B{sup +}\u00e2\u00cf{sup +}\u00cf\u00c2\u00b0, and B{sup +}\u00e2K{sup +}\u00cf\u00c2\u00b0 Decays and Isospin Analysis of the B\u00e2\u00cf\u00cf System",
        "abstract": "",
        "keywords": [
            "elementary particles",
            "standard model",
            "upper bound"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e graugespous",
                "org": ""
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2005
    },
    "25OjFtWS": {
        "id": "25OjFtWS",
        "title": "Branching Fraction Measurements of B{sup +}\ufffd\u03c1{sup +}\u03b3, B\u00b0\ufffd\u03c1\u00b0\u03b3, and B\u00b0\ufffd\ufffd\u03b3",
        "abstract": "",
        "keywords": [
            "gamma radiation",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "x prudent",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": "centre national de la recherche scientifique"
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            },
            {
                "name": "g s abrams",
                "org": "lawrence berkeley national laboratory"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2007
    },
    "vZpPpYOD": {
        "id": "vZpPpYOD",
        "title": "Evidence of a Broad Structure at an Invariant Mass of 4.32 GeV/c\u00c2\u00b2 in the Reaction e{sup +}e\u00e2\u00bb\u00e2\u00cf{sup +}\u00cf\u00e2\u00bb\u00cf(2S) Measured at BABAR",
        "abstract": "",
        "keywords": [
            "center of mass",
            "cross section",
            "mass spectra",
            "electron beam",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2007
    },
    "dvACDCkJ": {
        "id": "dvACDCkJ",
        "title": "Search for the decay B{sup +}{sup +}\u03bd{sub }",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Bernard Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J.-P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "Vincent Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": "Laboratoire de Physique des Particules, F-74941 Annecy-le-Vieux (France)"
            },
            {
                "name": "E. Grauges",
                "org": "IFAE, Universitat Autonoma de Barcelona, E-08193 Bellaterra, Barcelona (Spain)"
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "Alexis Pompili",
                "org": "Universita di Bari, Dipartimento di Fisica and INFN, I-70126 Bari (Italy)"
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. L. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": "Institute of High Energy Physics, Beijing 100039 (China)"
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": "University of Bergen, Institute of Physics, N-5007 Bergen (Norway)"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "v5uAInCh": {
        "id": "v5uAInCh",
        "title": "Search for D\u00b0-D\u00b0 Mixing and Branching-Ratio Measurement in the Decay D\u00b0\ufffdK{sup +}\ufffd\u207b\ufffd\u00b0",
        "abstract": "",
        "keywords": [
            "phase space",
            "data collection",
            "confidence level",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2006
    },
    "tqXDPgLc": {
        "id": "tqXDPgLc",
        "title": "Erratum: Dalitz-plot analysis of the decays B{sup {+-}}\u00e2K{sup {+-}}\u00cf{sup {+-}}\u00cf{sup {+-}} [Phys. Rev. D 72, 072003 (2005)]",
        "abstract": "",
        "keywords": [
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": ""
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": ""
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "yeRhqEMc": {
        "id": "yeRhqEMc",
        "title": "Search for B{yields}J/{psi}D decays",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "YwfMc7p9": {
        "id": "YwfMc7p9",
        "title": "Measurement of the ratio B(B{sup +}\ufffdXe\u03bd)/B(B\u00b0\ufffdXe\u03bd)",
        "abstract": "",
        "keywords": [
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": "centre national de la recherche scientifique"
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            },
            {
                "name": "g s abrams",
                "org": "lawrence berkeley national laboratory"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "svC1BODC": {
        "id": "svC1BODC",
        "title": "Study of the B{sup -}{yields}J/{psi}K{sup -}{pi}{sup +}{pi}{sup -} decay and measurement of the B{sup -}{yields}X(3872)K{sup -} branching fraction",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "J.M. Gaillard",
                "org": ""
            },
            {
                "name": "A. Hicheur",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "8o2jGp0s": {
        "id": "8o2jGp0s",
        "title": "Measurement of the B\u00c2\u00b0\u00e2\u00cf\u00e2\u00bbl{sup +}\u00ce\u00bd Form-Factor Shape and Branching Fraction, and Determination of vertical bar V{sub ub} vertical bar with a Loose Neutrino Reconstruction Technique",
        "abstract": "",
        "keywords": [
            "form factor",
            "momentum transfer",
            "lattice qcd",
            "quantum chromodynamics",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "x prudent",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": "centre national de la recherche scientifique"
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            },
            {
                "name": "g s abrams",
                "org": "lawrence berkeley national laboratory"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2007
    },
    "oN0S8BLV": {
        "id": "oN0S8BLV",
        "title": "Search for the decay B\u00b0\ufffda\ufffd{sup {+-}}\u03c1{sup {+-}}",
        "abstract": "",
        "keywords": [
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "ZusZhvt9": {
        "id": "ZusZhvt9",
        "title": "Evidence for the Rare Decay B{sup +}\ufffdD{sub s}{sup +}\ufffd\u00b0",
        "abstract": "",
        "keywords": [
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "x prudent",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": "centre national de la recherche scientifique"
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            },
            {
                "name": "g s abrams",
                "org": "lawrence berkeley national laboratory"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2007
    },
    "N33RMCyr": {
        "id": "N33RMCyr",
        "title": "Study of the \ufffd\u207b\ufffd3h\u207b2h{sup +}\u03bd{sub \ufffd} decay",
        "abstract": "",
        "keywords": [
            "phase space",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "akOxJzXa": {
        "id": "akOxJzXa",
        "title": "Measurement of B decays to \ufffdK\u03b3",
        "abstract": "",
        "keywords": [
            "confidence level",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": "centre national de la recherche scientifique"
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            },
            {
                "name": "g s abrams",
                "org": "lawrence berkeley national laboratory"
            }
        ],
        "venue": "Physical Review D",
        "year": 2007
    },
    "86MGuOQ8": {
        "id": "86MGuOQ8",
        "title": "Observation of B{sup +}\ufffd\ufffd\ufffdK{sup +} and Evidence for B\u00b0\ufffd\ufffd\ufffdK\u00b0 below \u03b7{sub c} Threshold",
        "abstract": "",
        "keywords": [
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": "centre national de la recherche scientifique"
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            },
            {
                "name": "g s abrams",
                "org": "lawrence berkeley national laboratory"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2006
    },
    "UfoNILEC": {
        "id": "UfoNILEC",
        "title": "Branching fraction measurement of B\u00b0D{sup (*)+} and BD{sup (*)0} and isospin analysis of BD{sup (*)} decays",
        "abstract": "",
        "keywords": [
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2007
    },
    "Ww5tEevg": {
        "id": "Ww5tEevg",
        "title": "Study of B{yields}{pi}l{nu} and B{yields}{rho}l{nu} decays and determination of vertical bar V{sub ub} vertical bar",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "iQLZwQp3": {
        "id": "iQLZwQp3",
        "title": "Structure at 2175\u00a0MeV in e+e-\u2192\u03d5f0(980) observed via initial-state radiation",
        "abstract": "We study the initial-state-radiation processes $e^+ e^- \\to K^+\nK^-\\pi^+\\pi^-\\gamma$ and $e^+ e^- \\to K^+ K^-\\pi^0\\pi^0\\gamma$ using an\nintegrated luminosity of 232 fb$^{-1}$ collected at the $\\Upsilon(4S)$ mass\nwith the BaBar detector at SLAC. Even though these reactions are dominated by\nintermediate states with excited kaons, we are able to study for the first time\nthe cross section for $e^+ e^- \\to \\phi(1020) f_{0}(980)$ as a function of\ncenter-of-mass energy. We observe a structure near threshold consistent with a\n$1^{--}$ resonance with mass $m = 2.175 \\pm 0.010\\pm 0.015 GeV/c^2$ and width\n$\\Gamma = 58\\pm 16\\pm 20 MeV$. We observe no Y(4260) signal and set a limit of\n$BR_{Y\\to\\phi\\pi^+\\pi^-}\\cdot\\Gamma^{Y}_{ee}<0.4$ eV (90% confidence level),\nwhich excludes some models.",
        "keywords": [
            "center of mass",
            "elementary particles",
            "confidence level",
            "cross section"
        ],
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "J. C. Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            },
            {
                "name": "G. Abrams",
                "org": ""
            },
            {
                "name": "M. Battaglia",
                "org": ""
            },
            {
                "name": "D. Brown",
                "org": ""
            },
            {
                "name": "J. Button-Shafer",
                "org": ""
            },
            {
                "name": "R. Cahn",
                "org": ""
            },
            {
                "name": "E. Charles",
                "org": ""
            },
            {
                "name": "M. Gill",
                "org": ""
            },
            {
                "name": "Y. Groysman",
                "org": ""
            },
            {
                "name": "R. Jacobsen",
                "org": ""
            },
            {
                "name": "J. Kadyk",
                "org": ""
            },
            {
                "name": "L. Kerth",
                "org": ""
            },
            {
                "name": "Yu. Kolomensky",
                "org": ""
            },
            {
                "name": "G. Kukartsev",
                "org": ""
            },
            {
                "name": "G. Lynch",
                "org": ""
            },
            {
                "name": "L. Mir",
                "org": ""
            },
            {
                "name": "T. Orimoto",
                "org": ""
            },
            {
                "name": "M. Pripstein",
                "org": ""
            },
            {
                "name": "N. Roe",
                "org": ""
            },
            {
                "name": "M. Ronan",
                "org": ""
            },
            {
                "name": "W. Wenzel",
                "org": ""
            },
            {
                "name": "P. Sanchez",
                "org": ""
            },
            {
                "name": "M. Barrett",
                "org": ""
            },
            {
                "name": "K. Ford",
                "org": ""
            },
            {
                "name": "T. Harrison",
                "org": ""
            },
            {
                "name": "A. Hart",
                "org": ""
            },
            {
                "name": "C. Hawkes",
                "org": ""
            },
            {
                "name": "A. Watson",
                "org": ""
            },
            {
                "name": "T. Held",
                "org": ""
            },
            {
                "name": "H. Koch",
                "org": ""
            },
            {
                "name": "B. Lewandowski",
                "org": ""
            },
            {
                "name": "M. Pelizaeus",
                "org": ""
            },
            {
                "name": "K. Peters",
                "org": ""
            },
            {
                "name": "T. Schroeder",
                "org": ""
            },
            {
                "name": "M. Steinke",
                "org": ""
            },
            {
                "name": "J. Boyd",
                "org": ""
            },
            {
                "name": "J. Burke",
                "org": ""
            },
            {
                "name": "W. Cottingham",
                "org": ""
            },
            {
                "name": "D. Walker",
                "org": ""
            },
            {
                "name": "D. Asgeirsson",
                "org": ""
            },
            {
                "name": "T. Cuhadar-Donszelmann",
                "org": ""
            },
            {
                "name": "B. Fulsom",
                "org": ""
            },
            {
                "name": "C. Hearty",
                "org": ""
            },
            {
                "name": "N. Knecht",
                "org": ""
            },
            {
                "name": "T. Mattison",
                "org": ""
            },
            {
                "name": "J. McKenna",
                "org": ""
            },
            {
                "name": "A. Khan",
                "org": ""
            },
            {
                "name": "P. Kyberd",
                "org": ""
            },
            {
                "name": "M. Saleem",
                "org": ""
            },
            {
                "name": "D. Sherwood",
                "org": ""
            },
            {
                "name": "L. Teodorescu",
                "org": ""
            },
            {
                "name": "V. Blinov",
                "org": ""
            },
            {
                "name": "A. Bukin",
                "org": ""
            },
            {
                "name": "V. Druzhinin",
                "org": ""
            },
            {
                "name": "V. Golubev",
                "org": ""
            },
            {
                "name": "A. Onuchin",
                "org": ""
            },
            {
                "name": "S. Serednyakov",
                "org": ""
            },
            {
                "name": "Yu. Skovpen",
                "org": ""
            },
            {
                "name": "E. Solodov",
                "org": ""
            },
            {
                "name": "K. Todyshev",
                "org": ""
            },
            {
                "name": "M. Bondioli",
                "org": ""
            },
            {
                "name": "M. Bruinsma",
                "org": ""
            },
            {
                "name": "M. Chao",
                "org": ""
            },
            {
                "name": "S. Curry",
                "org": ""
            },
            {
                "name": "I. Eschrich",
                "org": ""
            },
            {
                "name": "D. Kirkby",
                "org": ""
            },
            {
                "name": "A. Lankford",
                "org": ""
            },
            {
                "name": "P. Lund",
                "org": ""
            },
            {
                "name": "M. Mandelkern",
                "org": ""
            },
            {
                "name": "R. Mommsen",
                "org": ""
            },
            {
                "name": "W. Roethel",
                "org": ""
            },
            {
                "name": "D. Stoker",
                "org": ""
            },
            {
                "name": "S. Abachi",
                "org": ""
            },
            {
                "name": "C. Buchanan",
                "org": ""
            },
            {
                "name": "S. Foulkes",
                "org": ""
            },
            {
                "name": "J. Gary",
                "org": ""
            },
            {
                "name": "O. Long",
                "org": ""
            },
            {
                "name": "B. Shen",
                "org": ""
            },
            {
                "name": "K. Wang",
                "org": ""
            },
            {
                "name": "L. Zhang",
                "org": ""
            },
            {
                "name": "H. Hadavand",
                "org": ""
            },
            {
                "name": "E. Hill",
                "org": ""
            },
            {
                "name": "H. Paar",
                "org": ""
            },
            {
                "name": "S. Rahatlou",
                "org": ""
            },
            {
                "name": "V. Sharma",
                "org": ""
            },
            {
                "name": "J. Berryhill",
                "org": ""
            },
            {
                "name": "C. Campagnari",
                "org": ""
            },
            {
                "name": "A. Cunha",
                "org": ""
            },
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                "name": "B. Stugu",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "Kx8Yrlfh": {
        "id": "Kx8Yrlfh",
        "title": "Measurement of the branching ratios {gamma}(D{sub s}*{sup +}{yields}D{sub s}{sup +}{pi}{sup 0})/{gamma}(D{sub s}*{sup +}{yields}D{sub s}{sup +}{gamma}) and {gamma}(D*{sup 0}{yields}D{sup 0}{pi}{sup 0})/{gamma}(D*{sup 0}{yields}D{sup 0}{gamma})",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "XKlrDiOO": {
        "id": "XKlrDiOO",
        "title": "Measurement of the Branching Fraction of \ufffd(4S)\ufffdB\u00b0B\u00b0",
        "abstract": "",
        "keywords": [
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e graugespous",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2005
    },
    "KqtcnDMK": {
        "id": "KqtcnDMK",
        "title": "Search for D{sup 0}-D{sup 0} Mixing and Branching-Ratio Measurement in the Decay D{sup 0}{yields}K{sup +}{pi}{sup -}{pi}{sup 0}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2006
    },
    "qUUlEcpW": {
        "id": "qUUlEcpW",
        "title": "Measurement of the B\u00b0\ufffdK\ufffd*(1430)\u00b0\u03b3 and B{sup +}\ufffdK\ufffd*(1430){sup +}\u03b3 branching fractions",
        "abstract": "",
        "keywords": [
            "cp violation",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "j m gaillard",
                "org": ""
            },
            {
                "name": "a hicheur",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2004
    },
    "MwyQX26h": {
        "id": "MwyQX26h",
        "title": "Measurement of the absolute branching fractions B\ufffdD\ufffd, D*\ufffd, D**\ufffd with a missing mass method",
        "abstract": "",
        "keywords": [
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": "centre national de la recherche scientifique"
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "guangwei rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            },
            {
                "name": "g s abrams",
                "org": "lawrence berkeley national laboratory"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "gYhW42Pj": {
        "id": "gYhW42Pj",
        "title": "Amplitude analysis of the decay B{sup {+-}}{yields}{pi}{sup {+-}}{pi}{sup {+-}}{pi}{sup {+-}}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "beZlNrXs": {
        "id": "beZlNrXs",
        "title": "Study of the B\u00e2\u00bb\u00e2J/\u00cfK\u00e2\u00bb\u00cf{sup +}\u00cf\u00e2\u00bb decay and measurement of the B\u00e2\u00bb\u00e2X(3872)K\u00e2\u00bb branching fraction",
        "abstract": "",
        "keywords": [
            "energy storage",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "j m gaillard",
                "org": ""
            },
            {
                "name": "a hicheur",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "QB8Swla1": {
        "id": "QB8Swla1",
        "title": "Production and Decay of \u03be{sub c}\u00b0 at BABAR",
        "abstract": "",
        "keywords": [
            "center of mass",
            "spectrum",
            "data collection",
            "cross section",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2005
    },
    "osMxKIUY": {
        "id": "osMxKIUY",
        "title": "Measurement of branching fractions in radiative B decays to \u00ce\u00b7K\u00ce\u00b3 and search for B decays to \u00ce\u00b7{sup '}K\u00ce\u00b3",
        "abstract": "",
        "keywords": [
            "elementary particles",
            "confidence level"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "OkxglBjP": {
        "id": "OkxglBjP",
        "title": "Search for CP violation and a measurement of the relative branching fraction in D{sup +}\u00e2K\u00e2\u00bbK{sup +}\u00cf{sup +} decays",
        "abstract": "",
        "keywords": [
            "cp violation",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e graugespous",
                "org": ""
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "fdmFeWXP": {
        "id": "fdmFeWXP",
        "title": "Search for the rare decay B{sup 0}{yields}D*{sup 0}{gamma}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "oAGVmmTh": {
        "id": "oAGVmmTh",
        "title": "Study of B\ufffd\ufffdl\u03bd and B\ufffd\u03c1l\u03bd decays and determination of vertical bar V{sub ub} vertical bar",
        "abstract": "",
        "keywords": [
            "lattice qcd",
            "quantum chromodynamics",
            "elementary particles",
            "lattice field theory",
            "momentum transfer",
            "form factor"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "OwUm0Req": {
        "id": "OwUm0Req",
        "title": "Study of the X(3872) and Y(4260) in B\u00b0\ufffdJ/\ufffd\ufffd{sup +}\ufffd\u207bK\u00b0 and B\u207b\ufffdJ/\ufffd\ufffd{sup +}\ufffd\u207bK\u207b decays",
        "abstract": "",
        "keywords": [
            "energy storage",
            "confidence interval",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "guangwei rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "2VlPxL9e": {
        "id": "2VlPxL9e",
        "title": "Measurement of the branching fraction and decay rate asymmetry of B{sup -}{yields}D{sub {pi}{sup +}}{sub {pi}{sup -}}{sub {pi}{sup 0}}K{sup -}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "sust6AjS": {
        "id": "sust6AjS",
        "title": "Evidence for the decay B{sup {+-}}{yields}K*{sup {+-}}{pi}{sup 0}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "12VLgu1s": {
        "id": "12VLgu1s",
        "title": "Measurements of neutral B decay branching fractions to K{sub S}\u00b0\ufffd{sup +}\ufffd\u207b final states",
        "abstract": "",
        "keywords": [
            "elementary particles",
            "maximum likelihood",
            "cp violation"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "j m gaillard",
                "org": ""
            },
            {
                "name": "a hicheur",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2004
    },
    "9f7JxIz7": {
        "id": "9f7JxIz7",
        "title": "Branching fraction limits for B decays to {sup '}, {sup '} and",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Bernard Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J.-P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "Vincent Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": "Laboratoire de Physique des Particules, F-74941 Annecy-le-Vieux (France)"
            },
            {
                "name": "E. Grauges",
                "org": "Universitat de Barcelona, Fac. Fisica Dept. ECM, Avda Diagonal 647, 6a planta, E-08028 Barcelona (Spain)"
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": "Dipartimento di Fisica and INFN, Universita di Bari, I-70126 Bari (Italy)"
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. L. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": "Institute of High Energy Physics, Beijing 100039 (China)"
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": "University of Bergen, Institute of Physics, N-5007 Bergen (Norway)"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "lpXIok67": {
        "id": "lpXIok67",
        "title": "Measurement of CP asymmetry in B\ufffdK{sub s}\ufffd\ufffd\ufffd decays",
        "abstract": "",
        "keywords": [
            "maximum likelihood",
            "quantum chromodynamics",
            "elementary particles",
            "cp violation"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "x prudent",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": "centre national de la recherche scientifique"
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            },
            {
                "name": "g s abrams",
                "org": "lawrence berkeley national laboratory"
            }
        ],
        "venue": "Physical Review D",
        "year": 2007
    },
    "U36h6oO5": {
        "id": "U36h6oO5",
        "title": "Improved Measurement of the Cabibbo-Kobayashi-Maskawa Angle {alpha} Using B{sup 0}(B){yields}{rho}{sup +}{rho}{sup -} Decays",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2005
    },
    "7cPlrFu8": {
        "id": "7cPlrFu8",
        "title": "Searches for B\u00b0 decays to \u03b7K\u00b0, \u03b7\u03b7, \u03b7{sup '}\u03b7{sup '}, \u03b7\ufffd, and \u03b7{sup '}\ufffd",
        "abstract": "",
        "keywords": [
            "confidence level",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": "centre national de la recherche scientifique"
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            },
            {
                "name": "g s abrams",
                "org": "lawrence berkeley national laboratory"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "XQ6ztQBC": {
        "id": "XQ6ztQBC",
        "title": "Measurements of neutral B decay branching fractions to K{sub S}\u00c2\u00b0\u00cf{sup +}\u00cf\u00e2\u00bb final states and the charge asymmetry of B\u00c2\u00b0\u00e2K*{sup +}\u00cf\u00e2\u00bb",
        "abstract": "",
        "keywords": [
            "maximum likelihood",
            "elementary particles",
            "cp violation"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "rMilJVFQ": {
        "id": "rMilJVFQ",
        "title": "Vector-Tensor and Vector-Vector Decay Amplitude Analysis of B0\u2192\u03c6K*0",
        "abstract": "We perform an amplitude analysis of the decays B0->phi K^*_2(1430)0, phi\nK^*(892)0, and phi(K pi)^0_S-wave with a sample of about 384 million BBbar\npairs recorded with the BABAR detector. The fractions of longitudinal\npolarization f_L of the vector-tensor and vector-vector decay modes are\nmeasured to be 0.853 +0.061-0.069 +-0.036 and 0.506 +-0.040 +-0.015,\nrespectively. Overall, twelve parameters are measured for the vector-vector\ndecay and seven parameters for the vector-tensor decay, including the branching\nfractions and parameters sensitive to CP-violation.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "M. Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "J. C. Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            },
            {
                "name": "G. S. Abrams",
                "org": ""
            },
            {
                "name": "M. Battaglia",
                "org": ""
            },
            {
                "name": "D. N. Brown",
                "org": ""
            },
            {
                "name": "J. Button-Shafer",
                "org": ""
            },
            {
                "name": "R. N. Cahn",
                "org": ""
            },
            {
                "name": "E. Charles",
                "org": ""
            },
            {
                "name": "M. S. Gill",
                "org": ""
            },
            {
                "name": "Y. Groysman",
                "org": ""
            },
            {
                "name": "R. G. Jacobsen",
                "org": ""
            },
            {
                "name": "J. A. Kadyk",
                "org": ""
            },
            {
                "name": "L. T. Kerth",
                "org": ""
            },
            {
                "name": "G. Kolomensky",
                "org": ""
            },
            {
                "name": "G. Kukartsev",
                "org": ""
            },
            {
                "name": "D. Lopes Pegna",
                "org": ""
            },
            {
                "name": "G. Lynch",
                "org": ""
            },
            {
                "name": "L. M. Mir",
                "org": ""
            },
            {
                "name": "T. J. Orimoto",
                "org": ""
            },
            {
                "name": "M. Pripstein",
                "org": ""
            },
            {
                "name": "N. A. Roe",
                "org": ""
            },
            {
                "name": "M. T. Ronan",
                "org": ""
            },
            {
                "name": "W. A. Wenzel",
                "org": ""
            },
            {
                "name": "P. del Amo Sanchez",
                "org": ""
            },
            {
                "name": "M. Barrett",
                "org": ""
            },
            {
                "name": "K. E. Ford",
                "org": ""
            },
            {
                "name": "T. J. Harrison",
                "org": ""
            },
            {
                "name": "A. J. Hart",
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        "abstract": "",
        "keywords": [
            "quantum chromodynamics",
            "form factor",
            "lattice field theory",
            "elementary particles",
            "decay rate",
            "lattice qcd"
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        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "j m gaillard",
                "org": ""
            },
            {
                "name": "a hicheur",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "utS9GFjv": {
        "id": "utS9GFjv",
        "title": "Measurement of the time-dependent CP-violating asymmetry in B{sup 0}{yields}K{sub S}{sup 0}{pi}{sup 0}{gamma} decays",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "Lemepv2E": {
        "id": "Lemepv2E",
        "title": "Branching fraction measurements of charged B decays to K*{sup +}K{sup +}K\u00e2\u00bb, K*{sup +}\u00cf{sup +}K\u00e2\u00bb, K*{sup +}K{sup +}\u00cf\u00e2\u00bb and K*{sup +}\u00cf{sup +}\u00cf\u00e2\u00bb final states",
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        "keywords": [
            "confidence level",
            "maximum likelihood",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "FgK0TeYy": {
        "id": "FgK0TeYy",
        "title": "Search for the charmed pentaquark candidate {sub c}(3100)\u00b0 in e{sup +}e annihilations at (s)=10.58 GeV",
        "abstract": "",
        "keywords": [
            "center of mass",
            "cross section",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "QEVjlkGC": {
        "id": "QEVjlkGC",
        "title": "Search for the radiative decay B\u00b0\ufffd\ufffd\u03b3",
        "abstract": "",
        "keywords": [
            "confidence level",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e graugespous",
                "org": ""
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "Jj6YF5fX": {
        "id": "Jj6YF5fX",
        "title": "Dalitz plot analysis of the decay B{sup {+-}}\ufffdK{sup {+-}}K{sup {+-}}K{sup {+-}}",
        "abstract": "",
        "keywords": [
            "three body problem",
            "cp violation",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "betZDLeX": {
        "id": "betZDLeX",
        "title": "Branching Fraction and CP Asymmetries of B\u00b0\ufffdK{sub S}\u00b0K{sub S}\u00b0K{sub S}\u00b0",
        "abstract": "",
        "keywords": [
            "elementary particles",
            "cp violation"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tissserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e graugespous",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2005
    },
    "t4svZ8ph": {
        "id": "t4svZ8ph",
        "title": "Measurements of \u00ce\u00bb{sub c}{sup +} branching fractions of Cabibbo-suppressed decay modes involving \u00ce\u00bb and \u00cf\u00c2\u00b0",
        "abstract": "",
        "keywords": [
            "confidence level",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2007
    },
    "4IMqr4KW": {
        "id": "4IMqr4KW",
        "title": "Evidence for B{sup +}\u00e2K\u00c2\u00b0K{sup +} and B\u00c2\u00b0\u00e2K\u00c2\u00b0K\u00c2\u00b0, and Measurement of the Branching Fraction and Search for Direct CP Violation in B{sup +}\u00e2K\u00c2\u00b0\u00cf{sup +}",
        "abstract": "",
        "keywords": [
            "cp violation",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2005
    },
    "8SHv7Q8w": {
        "id": "8SHv7Q8w",
        "title": "Search for Lepton Flavor Violation in the Decay {tau}{sup {+-}}{yields}e{sup {+-}}{gamma}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2006
    },
    "BUAf5nLD": {
        "id": "BUAf5nLD",
        "title": "Observation of B\u03b7{sup '}K{sup *} and Evidence for B{sup +}\u03b7{sup '}\u03c1{sup +}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Bernard Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "Marcella Bona",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J.-P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "Vincent Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": "Laboratoire de Physique des Particules, F-74941 Annecy-le-Vieux (France)"
            },
            {
                "name": "E. Grauges",
                "org": "Universitat de Barcelona, Facultat de Fisica Departament ECM, E-08028 Barcelona (Spain)"
            },
            {
                "name": "A. Palano",
                "org": "Universita di Bari, Dipartimento di Fisica and INFN, I-70126 Bari (Italy)"
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N. D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. L. Wang",
                "org": ""
            },
            {
                "name": "Y. S. Zhu",
                "org": "Institute of High Energy Physics, Beijing 100039 (China)"
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "Bjarne Stugu",
                "org": "University of Bergen, Institute of Physics, N-5007 Bergen (Norway)"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2007
    },
    "kr0XBjhI": {
        "id": "kr0XBjhI",
        "title": "Branching fraction limits for B\ufffd decays to {sup '}, {sup '}\ufffd and \ufffd",
        "abstract": "",
        "keywords": [
            "data collection",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "tb1z4vTg": {
        "id": "tb1z4vTg",
        "title": "Improved Measurement of the Cabibbo-Kobayashi-Maskawa Angle \u03b1 Using B\u00b0(B)\ufffd\u03c1{sup +}\u03c1\u207b Decays",
        "abstract": "",
        "keywords": [
            "elementary particles",
            "cp violation",
            "standard model"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2005
    },
    "nTDw1bR6": {
        "id": "nTDw1bR6",
        "title": "Measurement of time-dependent CP asymmetries in B\u00c2\u00b0\u00e2D{sup (*){+-}}\u00cf{sup {+-}} and B\u00c2\u00b0\u00e2D{sup {+-}}\u00cf{sup {+-}} decays",
        "abstract": "",
        "keywords": [
            "elementary particles",
            "confidence level",
            "maximum likelihood",
            "cp violation"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "ZdTgzepC": {
        "id": "ZdTgzepC",
        "title": "Measurement of the Cabibbo-Kobayashi-Maskawa Angle \u00ce\u00b3 in B{sup {+-}}\u00e2D{sup (*)}K{sup {+-}} Decays with a Dalitz Analysis of D\u00e2K{sub S}\u00c2\u00b0\u00cf\u00e2\u00bb\u00cf{sup +}",
        "abstract": "",
        "keywords": [
            "cp violation",
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2005
    },
    "7QWHYOpZ": {
        "id": "7QWHYOpZ",
        "title": "Measurement of the B\u00e2\u00cfl\u00ce\u00bd Branching Fraction and Determination of vertical bar V{sub ub} vertical bar with Tagged B Mesons",
        "abstract": "",
        "keywords": [
            "data collection",
            "form factor",
            "momentum transfer",
            "elementary particles",
            "lattice qcd",
            "quantum chromodynamics"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "m bona",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "university of barcelona"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "guangwei rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2006
    },
    "oEOcDkKg": {
        "id": "oEOcDkKg",
        "title": "Search for the Rare Leptonic Decay B\u207b\ufffd\ufffd\u207b\u03bd{sub \ufffd}",
        "abstract": "",
        "keywords": [
            "elementary particles",
            "confidence level"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "j m gaillard",
                "org": ""
            },
            {
                "name": "a hicheur",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "guangwei rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": ""
            },
            {
                "name": "b stugu",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review Letters",
        "year": 2005
    },
    "zhuh5Bko": {
        "id": "zhuh5Bko",
        "title": "Search for the rare decays B\ufffdD{sub s}{sup (*)+}a{sub 0(2)}",
        "abstract": "",
        "keywords": [
            "elementary particles"
        ],
        "authors": [
            {
                "name": "bernard aubert",
                "org": ""
            },
            {
                "name": "r barate",
                "org": ""
            },
            {
                "name": "d boutigny",
                "org": ""
            },
            {
                "name": "f couderc",
                "org": ""
            },
            {
                "name": "y karyotakis",
                "org": ""
            },
            {
                "name": "j p lees",
                "org": ""
            },
            {
                "name": "v poireau",
                "org": ""
            },
            {
                "name": "v tisserand",
                "org": ""
            },
            {
                "name": "a zghiche",
                "org": ""
            },
            {
                "name": "e grauges",
                "org": "ifae"
            },
            {
                "name": "a palano",
                "org": ""
            },
            {
                "name": "m pappagallo",
                "org": ""
            },
            {
                "name": "a pompili",
                "org": ""
            },
            {
                "name": "jie chen",
                "org": ""
            },
            {
                "name": "n d qi",
                "org": ""
            },
            {
                "name": "g rong",
                "org": ""
            },
            {
                "name": "p l wang",
                "org": ""
            },
            {
                "name": "y s zhu",
                "org": "institute of high energy physics"
            },
            {
                "name": "g eigen",
                "org": ""
            },
            {
                "name": "i ofte",
                "org": "university of bergen"
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "uxlR30zk": {
        "id": "uxlR30zk",
        "title": "Measurement of the B{sup -}{yields}D{sup 0}K*{sup -} branching fraction",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            },
            {
                "name": "B. Stugu",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2006
    },
    "Jk4HIB0D": {
        "id": "Jk4HIB0D",
        "title": "Study of b{yields}c interference in the decay B{sup -}{yields}[K{sup +}{pi}{sup -}]{sub D}K*{sup -}",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "B. Aubert",
                "org": ""
            },
            {
                "name": "R. Barate",
                "org": ""
            },
            {
                "name": "D. Boutigny",
                "org": ""
            },
            {
                "name": "F. Couderc",
                "org": ""
            },
            {
                "name": "Y. Karyotakis",
                "org": ""
            },
            {
                "name": "J. P. Lees",
                "org": ""
            },
            {
                "name": "V. Poireau",
                "org": ""
            },
            {
                "name": "V. Tisserand",
                "org": ""
            },
            {
                "name": "A. Zghiche",
                "org": ""
            },
            {
                "name": "E. Grauges",
                "org": ""
            },
            {
                "name": "A. Palano",
                "org": ""
            },
            {
                "name": "M. Pappagallo",
                "org": ""
            },
            {
                "name": "A. Pompili",
                "org": ""
            },
            {
                "name": "Jie Chen",
                "org": ""
            },
            {
                "name": "N.D. Qi",
                "org": ""
            },
            {
                "name": "G. Rong",
                "org": ""
            },
            {
                "name": "P. Wang",
                "org": ""
            },
            {
                "name": "Y.S. Zhu",
                "org": ""
            },
            {
                "name": "G. Eigen",
                "org": ""
            },
            {
                "name": "I. Ofte",
                "org": ""
            }
        ],
        "venue": "Physical Review D",
        "year": 2005
    },
    "dIiC58bg": {
        "id": "dIiC58bg",
        "title": "Dual-Comb Absolute Distance Measurement Based on a Dual-Wavelength Passively Mode-Locked Laser",
        "abstract": "A new absolute distance measurement system is demonstrated in this paper, which is based on a dual-wavelength passive mode-locked fiber laser. By controlling the intracavity loss and spectral filtering, the cavity mode-locked by a single-wall carbon nanotube saturable absorber is able to generate two pulse trains at slightly different repetition rates simultaneously with high mutual coherence. Comparisons with the commercial interferometers located on the 80-m large-scale dimensional standard show a combined measurement uncertainty of 6\u00a0   $mu$     $m+1times {10}^{-7}L,(k=2)$  , in an averaging time of 1\u00a0s. Our compact dual-comb system provides a low-cost way for ranging, with continuous range, rapid measurement, and high resolution.",
        "keywords": "",
        "authors": [
            {
                "name": "Baike Lin",
                "org": "National Institute of Metrology, Beijing, China"
            },
            {
                "name": "Xin Zhao",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, China"
            },
            {
                "name": "Mingzhao He",
                "org": "National Institute of Metrology, Beijing, China"
            },
            {
                "name": "Yingling Pan",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, China"
            },
            {
                "name": "Jie Chen",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, China"
            },
            {
                "name": "Shiying Cao",
                "org": "National Institute of Metrology, Beijing, China"
            },
            {
                "name": "Yige Lin",
                "org": "National Institute of Metrology, Beijing, China"
            },
            {
                "name": "Qiang Wang",
                "org": "National Institute of Metrology, Beijing, China"
            },
            {
                "name": "Zheng Zheng",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, China"
            },
            {
                "name": "Zhanjun Fang",
                "org": ""
            }
        ],
        "venue": "IEEE Photonics Journal",
        "year": 2017
    },
    "TqEBXCfl": {
        "id": "TqEBXCfl",
        "title": "Spectrally resolved shot-by-shot intensity noise characteristics of soliton spectrum broadening in normal dispersion single-mode fiber",
        "abstract": "Spectral intensity noise distribution of pulses after spectral broadening in single-mode fiber with normal dispersion is experimentally investigated, and vastly different noise magnitudes and some low-noise regions farther away from the pump wavelength are observed.",
        "keywords": "",
        "authors": [
            {
                "name": "Zijun Yao",
                "org": "Beihang University"
            },
            {
                "name": "Jie Chen",
                "org": "Beihang University"
            },
            {
                "name": "Ting Li",
                "org": "Beihang University"
            },
            {
                "name": "Yu Zhang",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "Xin Zhao",
                "org": "Beihang University"
            },
            {
                "name": "Zheng Zheng",
                "org": "Beihang University"
            }
        ],
        "venue": "conference on lasers and electro optics",
        "year": 2018
    },
    "TIHiopRh": {
        "id": "TIHiopRh",
        "title": "Adaptive Sampling Terahertz Dual-Comb Spectroscopy Based on a Free-Running Single-Cavity Dual-Comb Fiber Laser",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Beihang University"
            },
            {
                "name": "Kuzuki Nitta",
                "org": ""
            },
            {
                "name": "Xin Zhao",
                "org": "Beihang University"
            },
            {
                "name": "Takahiko Mizuno",
                "org": "University of Tokushima"
            },
            {
                "name": "Takeo Minamikawa",
                "org": "University of Tokushima"
            },
            {
                "name": "Zheng Zheng",
                "org": "Beihang University"
            },
            {
                "name": "Takeshi Yasui",
                "org": "University of Tokushima"
            }
        ],
        "venue": "conference on lasers and electro-optics",
        "year": 2019
    },
    "ZdIhd89b": {
        "id": "ZdIhd89b",
        "title": "Dual-comb spectroscopy of methan based on an Erbium dual-comb fiber laser",
        "abstract": "Dual-comb spectroscopy measurement of methan absorption around 1650nm is demonstrated using a dual-wavelength Erbium mode-locked fiber laser, which illustrates the capability of such single-cavity dual-comb sources to cover spectral range well beyond their initial bandwidth.",
        "keywords": "",
        "authors": [
            {
                "name": "Jie Chen",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Xin Zhao",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Yuehan Wu",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Ting Li",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Ruliu Wang",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Qian Li",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Siyao Yin",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Jiansheng Liu",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Zheng",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            }
        ],
        "venue": "conference on lasers and electro optics",
        "year": 2018
    },
    "ybtKONO7": {
        "id": "ybtKONO7",
        "title": "Dual-comb spectroscopy using a hybrid mode-locked fiber laser",
        "abstract": "Dual-comb absorption spectroscopy is realized by using a dispersion-managed, hybrid mode-locked fiber laser, which emit two pulse trains with different bandwidths due to hybrid pulse formation mechanisms.",
        "keywords": "",
        "authors": [
            {
                "name": "Ting Li",
                "org": "Beihang University"
            },
            {
                "name": "Xin Zhao",
                "org": "Beihang University"
            },
            {
                "name": "Zijun Yao",
                "org": "Beihang University"
            },
            {
                "name": "Yuehan Wu",
                "org": "Beihang University"
            },
            {
                "name": "Jie Chen",
                "org": "Beihang University"
            },
            {
                "name": "Zheng Zheng",
                "org": "Beihang University"
            }
        ],
        "venue": "conference on lasers and electro optics",
        "year": 2018
    },
    "vtjmj01c": {
        "id": "vtjmj01c",
        "title": "Solving large-scale NP-Complete problem with an optical solver driven by a dual-comb \u2018clock\u2019",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yalin Hou",
                "org": ""
            },
            {
                "name": "Xin Zhao",
                "org": "Beihang University"
            },
            {
                "name": "Qian Li",
                "org": "Beihang University"
            },
            {
                "name": "Jie Chen",
                "org": "Beihang University"
            },
            {
                "name": "Yihong Li",
                "org": ""
            },
            {
                "name": "Zheng Zheng",
                "org": "Beihang University"
            }
        ],
        "venue": "conference on lasers and electro-optics",
        "year": 2019
    },
    "Daq7VFmN": {
        "id": "Daq7VFmN",
        "title": "Dual-wavelength, dual-comb fiber laser based on a nearly-adiabatic fiber-taper filter",
        "abstract": "A simple, turn-key dual-comb laser is realized by leveraging a fiber-taper filter based on multi-mode interference. The low modulation depth of the filter with a nearly adiabetic profile improves the bandwidth of the generated pulses.",
        "keywords": "",
        "authors": [
            {
                "name": "Jie Chen",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Tianlei Zhang",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Ruliu Wang",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Guoqing Hu",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Xin Zhao",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Jiansheng Liu",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Zheng Zheng",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            }
        ],
        "venue": "Frontiers in Optics",
        "year": 2016
    },
    "XgDpisAc": {
        "id": "XgDpisAc",
        "title": "Tri-comb and quad-comb generation from a multidimensional-multiplexed fiber laser",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Ting Li",
                "org": "Beihang University"
            },
            {
                "name": "Xin Zhao",
                "org": "Beihang University"
            },
            {
                "name": "Jie Chen",
                "org": "Beihang University"
            },
            {
                "name": "Qian Li",
                "org": "Beihang University"
            },
            {
                "name": "Zheng Zheng",
                "org": "Beihang University"
            }
        ],
        "venue": "conference on lasers and electro-optics",
        "year": 2019
    },
    "gkkJesN3": {
        "id": "gkkJesN3",
        "title": "Tri-Comb and Quad-Comb Generation Based on a Multi-Dimensional Multiplexed Mode-Locked Laser",
        "abstract": "By introducing an additional comb beyond its dual-comb predecessor, tri-comb consisting of three combs with different mode spacing has shown its unique potential in several metrology areas such as nonlinear spectroscopy, frequency, and distance measurement. However, tri-comb generation based on three frequency-stabilized comb lasers would be overly complicated and costly for many potential applications. Previous studies had realized dual-comb generation from a single-cavity laser by leveraging multiplexing in one of the waveguiding dimensions of the optical pulses. Such sources with built-in passive mutual coherence could greatly reduce system complexity. Yet, squeezing more combs into one multiplexing dimension becomes increasingly difficult without significant sacrifice in performance, which could jeopardize the usefulness of such a scheme. In this paper, it is proposed and demonstrated that multi-comb generation could be realized by tapping into the multidimensional joint parameter space. Up to four wavelength/polarization multiplexed, asynchronous ultrashort pulse sequences can be generated with good stability from an all-fiber, mode-locked ring-cavity laser. This could offer an attractive alternative solution as the low-complexity light sources for field-deployable multi-comb metrology applications.",
        "keywords": [
            "Multiplexing",
            "Laser mode locking",
            "Optical fiber polarization",
            "Cavity resonators",
            "Erbium-doped fiber lasers",
            "Optical fiber couplers",
            "Optical fiber dispersion"
        ],
        "authors": [
            {
                "name": "Ting Li",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, China"
            },
            {
                "name": "Xin Zhao",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, China"
            },
            {
                "name": "Jie Chen",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, China"
            },
            {
                "name": "Qian Li",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, China"
            },
            {
                "name": "Shuguo Xie",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, China"
            },
            {
                "name": "Zheng Zheng",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, China"
            }
        ],
        "venue": "Journal of Lightwave Technology",
        "year": 2019
    },
    "ferOrI4T": {
        "id": "ferOrI4T",
        "title": "Combination of Adaptive Sampling Terahertz Dual-Comb Spectroscopy with a Free-Running Single-Cavity Dual-Comb Fiber Laser",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jie Chen",
                "org": "Beihang University, Beijing, 1000831, China"
            },
            {
                "name": "Kuzuki Nitta",
                "org": "Tokushima University, Tokushima, 770-8506, Japan"
            },
            {
                "name": "Xin Zhao",
                "org": "Beihang University, Beijing, 1000831, China"
            },
            {
                "name": "Takahiko Mizuno",
                "org": "Tokushima University, Tokushima, 770-8506, Japan"
            },
            {
                "name": "Takeo Minamikawa",
                "org": "Tokushima University, Tokushima, 770-8506, Japan"
            },
            {
                "name": "Zheng Zheng",
                "org": "Beihang University, Beijing, 1000831, China"
            },
            {
                "name": "Takeshi Yasui",
                "org": "Tokushima University, Tokushima, 770-8506, Japan"
            }
        ],
        "venue": "international conference on infrared millimeter and terahertz waves",
        "year": 2019
    },
    "hc1nuOWq": {
        "id": "hc1nuOWq",
        "title": "Dual-fiber SERS chip using monolayer gold nanoparticles self-assembled on optical fiber end",
        "abstract": "Utilizing the mended classical nanoparticle self-assembly strategy, we designed a novel low-cost, convenient and rapid detection dual-fiber SERS chip taking both advantage of self-assembly and photodeposition and obtained the optimal detection condition through experiments.",
        "keywords": "",
        "authors": [
            {
                "name": "Hongwen Zhou",
                "org": "School of Electronic and Information Engineering, Beihang University, 37 Xueyuan Road, Beijing 100191, China"
            },
            {
                "name": "Haitao Liu",
                "org": "School of Electronic and Information Engineering, Beihang University, 37 Xueyuan Road, Beijing 100191, China"
            },
            {
                "name": "Luoyang Chen",
                "org": "School of Electronic and Information Engineering, Beihang University, 37 Xueyuan Road, Beijing 100191, China"
            },
            {
                "name": "Jie Chen",
                "org": "School of Electronic and Information Engineering, Beihang University, 37 Xueyuan Road, Beijing 100191, China"
            }
        ],
        "venue": "conference on lasers and electro optics",
        "year": 2016
    },
    "knQaNggH": {
        "id": "knQaNggH",
        "title": "Self-expanding fabricated bubble resonators used as whispering gallery modes sensors",
        "abstract": "Employing low-cost high borosilicate glass capillaries, self-expanding bubble resonator fabrication method based on air thermal expansion is demonstrated. Detected quality factor Q is as high as 10 5 . 54 pm light perturbation mode shift was sensed.",
        "keywords": "",
        "authors": [
            {
                "name": "Hongwen Zhou",
                "org": "1 School of Electronic and Information Engineering, Beihang University, 37 Xueyuan Road, Beijing 100191, China"
            },
            {
                "name": "Jiansheng Liu",
                "org": "1 School of Electronic and Information Engineering, Beihang University, 37 Xueyuan Road, Beijing 100191, China"
            },
            {
                "name": "Meng Zhang",
                "org": "1 School of Electronic and Information Engineering, Beihang University, 37 Xueyuan Road, Beijing 100191, China"
            },
            {
                "name": "Jie Chen",
                "org": "1 School of Electronic and Information Engineering, Beihang University, 37 Xueyuan Road, Beijing 100191, China"
            },
            {
                "name": "Xiaosheng Liu",
                "org": "1 School of Electronic and Information Engineering, Beihang University, 37 Xueyuan Road, Beijing 100191, China"
            },
            {
                "name": "Q. Wu",
                "org": "1 School of Electronic and Information Engineering, Beihang University, 37 Xueyuan Road, Beijing 100191, China"
            },
            {
                "name": "Zheng Zheng",
                "org": "1 School of Electronic and Information Engineering, Beihang University, 37 Xueyuan Road, Beijing 100191, China"
            }
        ],
        "venue": "conference on lasers and electro optics",
        "year": 2018
    },
    "9qH3VMEZ": {
        "id": "9qH3VMEZ",
        "title": "Polarization-maintaining, dual-wavelength, dual-comb mode-locked fiber laser",
        "abstract": "A self-starting, dual-wavelength, dual-comb mode-locked fiber laser based on all polarization-maintaining parts and a carbon nanotube modelocker is demonstrated, and dual-wavelength operation is realized through spatial filtering facilitated by waveplates in the cavity.",
        "keywords": "",
        "authors": [
            {
                "name": "Ruliu Wang",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Xin Zhao",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Weinan Bai",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Jie Chen",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Yingling Pan",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Zheng Zheng",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            }
        ],
        "venue": "conference on lasers and electro optics",
        "year": 2018
    },
    "R1RQ1Qjm": {
        "id": "R1RQ1Qjm",
        "title": "Tri-comb and Quad-comb Generation Based on a Multi-dimensional Multiplexed Mode-locked Laser",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Ting Li",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, Beijing China (e-mail: liting16@buaa.edu.cn)"
            },
            {
                "name": "Xin Zhao",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, Beijing China (e-mail: x.zhao@buaa.edu.cn)"
            },
            {
                "name": "Jie Chen",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, Beijing China (e-mail: cjyeah@buaa.edu.cn)"
            },
            {
                "name": "Qian Li",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, Beijing China (e-mail: lqbhs@buaa.edu.cn)"
            },
            {
                "name": "Shuguo Xie",
                "org": "School of Electronic and Information Engineering, Beihang University, 12633 Beijing, Beijing China (e-mail: xieshuguo@buaa.edu.cn)"
            },
            {
                "name": "Zheng Zheng",
                "org": "School of Electronic and Information Engineering, Beihang University, 12633 Beijing, Beijing China (e-mail: zhengzheng@buaa.edu.cn)"
            }
        ],
        "venue": "Journal of Lightwave Technology",
        "year": 2019
    },
    "9JqaHSXI": {
        "id": "9JqaHSXI",
        "title": "High-resolution, dynamic fiber Bragg grating sensing base on dual-comb spectroscopy with a single fiber laser",
        "abstract": "Enabled by a dual-comb fiber laser, real-time interrogation of fiber Bragg gratingu0027s spectral response is realized using the dual-comb spectroscopy scheme. kHz sampling speed and pm accuracy are simultaneously achieved with a simple fiber-optic setup.",
        "keywords": "",
        "authors": [
            {
                "name": "Xin Zhao",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Qian Li",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Siyao Yin",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Jie Chen",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Zheng Zheng",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            }
        ],
        "venue": "conference on lasers and electro optics",
        "year": 2018
    },
    "9fsjPbEQ": {
        "id": "9fsjPbEQ",
        "title": "Self-starting, turn-key dual-comb mode-locked fiber laser with a few-mode fiber filter",
        "abstract": "A simple, self-starting and stable dual-wavelength-comb mode-locked fiber laser is realized with a dual-mode-fiber-based filter. The cost-effective, multimode interference fiber filter with low spectral modulation depth enables relatively wide spectral bandwidths in the mode-locking windows.",
        "keywords": "",
        "authors": [
            {
                "name": "Jie Chen",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Ruliu Wang",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Ting Li",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Cui Li",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Yingling Pan",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Xin Zhao",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Jiansheng Liu",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            },
            {
                "name": "Zheng Zheng",
                "org": "School of Electronic and Information Engineering, Beihang University, Beijing, 100083, China"
            }
        ],
        "venue": "conference on lasers and electro optics",
        "year": 2017
    },
    "vPoNfjjb": {
        "id": "vPoNfjjb",
        "title": "Mode and sensing properties of the deformed micro-droplet",
        "abstract": "The resonant mode along meridian of a deformed droplet on a hydrophilic substrate with different contact angle CA is investigated. A relatively large Q \u223c 2000 and a sensitivity S \u223c 550 nm/ RIU can still be achieved even with CA down to 150\u00b0.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhang Meng",
                "org": "School of Electronic and Information Engineering, Beihang University, 37 Xueyuan Rd, Beijing 100191, China"
            },
            {
                "name": "Liu Jiansheng",
                "org": "School of Electronic and Information Engineering, Beihang University, 37 Xueyuan Rd, Beijing 100191, China"
            },
            {
                "name": "Cheng Weifeng",
                "org": "Department of Mechanical Engineering, Virginia Tech, 635 Prices Fork Road, Blacksburg, VA 24061, USA"
            },
            {
                "name": "Cheng Jiangtao",
                "org": "Department of Mechanical Engineering, Virginia Tech, 635 Prices Fork Road, Blacksburg, VA 24061, USA"
            },
            {
                "name": "Zhou Hongwen",
                "org": "School of Electronic and Information Engineering, Beihang University, 37 Xueyuan Rd, Beijing 100191, China"
            },
            {
                "name": "Liu Haitao",
                "org": "School of Electronic and Information Engineering, Beihang University, 37 Xueyuan Rd, Beijing 100191, China"
            },
            {
                "name": "Jie Chen",
                "org": "School of Electronic and Information Engineering, Beihang University, 37 Xueyuan Rd, Beijing 100191, China"
            },
            {
                "name": "Wu qing",
                "org": "School of Electronic and Information Engineering, Beihang University, 37 Xueyuan Rd, Beijing 100191, China"
            },
            {
                "name": "Wan Yuhang",
                "org": "School of Electronic and Information Engineering, Beihang University, 37 Xueyuan Rd, Beijing 100191, China"
            },
            {
                "name": "Zheng Zheng",
                "org": "School of Electronic and Information Engineering, Beihang University, 37 Xueyuan Rd, Beijing 100191, China"
            }
        ],
        "venue": "conference on lasers and electro optics",
        "year": 2018
    },
    "ioomrzC1": {
        "id": "ioomrzC1",
        "title": "Effect of Yishen Hugu Decoction on Animal Model of Disused Osteoporosis in Rats",
        "abstract": "Objective: To study the effect of Yishen Hugu Decoction on the changes of the blood and urine biochemical levels,the bone structure,bone biomechanical properties in the animal model of disused osteoporosis in rats.Methods: 70 SD rats of 3 months were randomly divided into 7 groups: normal group,sham operation group,model group,high dose of Yishen Hugu Decoction group,medium dose of Yishen Hugu Decoction group,low dose of Yishen Hugu Decoction group and drug control group(Drynaria fortunei),each group had 10 rats.The rats in the groups of model group,high,medium,low dose of Yishen Hugu Decoction groups and drug control group were given sciatic neurotomy.Normal group was given regular food and water supply,the rats in high,medium,low dose of Yishen Hugu Decoction groups were given gavage by a concentration of 52 g / kg,26 g / kg,16.25 g / kg dose of Yishen Hugu Decoction respectively,and the rats in drug control group were given gavage by a concentration of 0.25 g / kg dose of Drynaria fortunei.The blood and urine biochemical levels were measured,the femora biomechanical test,the tibia were decalcified and then stained with HE and Masson stain.Results: The differences of ALP,BGP,Strap,HOP / Cr,BMD and the numbers of nodes and free ends of model group and sham operation group were statically significant(P < 0.01).After gavage by Yishen Hugu Decoction,those indexes of high,medium,low dose of Yishen Hugu Decoction groups were obviously higher or lower than that of model group(P < 0.01).Conclusion: The disused osteoporosis can be prevented effectively by Yishen Hugu Decoction in the index of blood and urine biochemical levels,the bone structure,bone biomechanical properties and disuse osteoporosis in rats.",
        "keywords": [
            "Drynaria Fortunei total flavonoids",
            "Yishen Hugu Decoction",
            "disused osteoporosis",
            "animal model",
            "bone metabolism"
        ],
        "authors": [
            {
                "name": "ZHANG Qiande",
                "org": "Traditional Chinese and Western Medicine Research Institute of Nanjing Medical University,Nanjing ,Jiangsu,China"
            },
            {
                "name": "GAO Jun",
                "org": "Department of Orthopaedics,Changzhou Hospital of Traditional Chinese Medicine,Changzhou ,Jiangsu,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "Department of Orthopaedics,Changzhou Hospital of Traditional Chinese Medicine,Changzhou ,Jiangsu,China"
            },
            {
                "name": "GAN Ke",
                "org": "Nanjing University of Chinese Medicine,Nanjing ,Jiangsu,China"
            }
        ],
        "venue": "Liaoning Journal of Traditional Chinese Medicine",
        "year": 2013
    },
    "BcEIyXnN": {
        "id": "BcEIyXnN",
        "title": "Closed reduction and micro-incision for the treatment of distal tibia fractures]",
        "abstract": "",
        "keywords": [
            "orthopedic",
            "internal",
            "manipulation",
            "fracture fixation",
            "tibial fractures"
        ],
        "authors": [
            {
                "name": "Xi Zhang",
                "org": "Department of Orthopaedics, TCM Hospital of Changzhou Affiliated to Nanjing University of TCM, Changzhou 213003, Jiangsu, China. gkax@163.com"
            },
            {
                "name": "Zheng-Xiang L\u00fc",
                "org": ""
            },
            {
                "name": "Yong-Hua Sheng",
                "org": ""
            },
            {
                "name": "Xing-Biao Wu",
                "org": ""
            },
            {
                "name": "Jun Gao",
                "org": ""
            },
            {
                "name": "Wei-Hua Zhao",
                "org": ""
            },
            {
                "name": "Hong-Ming Tao",
                "org": ""
            }
        ],
        "venue": "Zhongguo gu shang = China journal of orthopaedics and traumatology",
        "year": 2010
    },
    "dlWUfQcO": {
        "id": "dlWUfQcO",
        "title": "MRI analysis of the ISOBAR TTL internal fixation system for the dynamic fixation of intervertebral discs: a comparison with rigid internal fixation.",
        "abstract": "Using magnetic resonance imaging (MRI), we analyzed the efficacy of the posterior approach lumbar ISOBAR TTL internal fixation system for the dynamic fixation of intervertebral discs, with particular emphasis on its effects on degenerative intervertebral disc disease.We retrospectively compared the MRIs of 54 patients who had previously undergone either rigid internal fixation of the lumbar spine or ISOBAR TTL dynamic fixation for the treatment of lumbar spondylolisthesis. All patients had received preoperative and 6-, 12-, and 24-month postoperative MRI scans of the lumbar spine with acquisition of both routine and diffusion-weighted images (DWI). The upper-segment discs of the fusion were subjected to Pfirrmann grading, and the lumbar intervertebral discs in the DWI sagittal plane were manually drawn; the apparent diffusion coefficient (ADC) value was measured.ADC values in the ISOBAR TTL dynamic fixation group measured at the 6-, 12-, and 24-month postoperative MRI studies were increased compared to the preoperative ADC values. The ADC values in the ISOBAR TTL dynamic fixation group at 24 months postoperatively were significantly different from the preoperative values (P\u2009<\u20090.05). At 24 months, the postoperative ADC values were significantly different between the rigid fixation group and the ISOBAR TTL dynamic fixation group (P\u2009<\u20090.05).MRI imaging findings indicated that the posterior approach lumbar ISOBAR TTL internal fixation system can prevent or delay the degeneration of intervertebral discs.",
        "keywords": [
            "orthopedics",
            "retrospective studies",
            "magnetic resonance imaging"
        ],
        "authors": [
            {
                "name": "Jun Gao",
                "org": ""
            },
            {
                "name": "Weihua Zhao",
                "org": ""
            },
            {
                "name": "Xi Zhang",
                "org": "Department of Orthopedics, Changzhou Traditional Chinese Medicine Hospital, Nanjing Traditional Chinese Medical University, Changzhou 213003, China. XiZhangdoc@126.com."
            },
            {
                "name": "Luming Nong",
                "org": ""
            },
            {
                "name": "Dong Zhou",
                "org": ""
            },
            {
                "name": "Zhengxiang Lv",
                "org": ""
            },
            {
                "name": "Yonghua Sheng",
                "org": ""
            },
            {
                "name": "Xingbiao Wu",
                "org": ""
            }
        ],
        "venue": "Journal of orthopaedic surgery and research",
        "year": 2014
    },
    "vaLDafYY": {
        "id": "vaLDafYY",
        "title": "Effect of cold compress of mirabilite ice pack on relieving the swelling pain of wound",
        "abstract": "Objective To discuss the more effective method to relieve the swelling pain of wound.Methods One hundred and seventy patients with swelling pain of wound were randomly divided into experimental group (n=85) and control group (n=85).Applying cold compress with mirabilite ice pack and ice pack of water in experimental group and control group respectively.Results Compared with control group,the degree of pain in experimental group had significant difference on 1, 24, 48 hours after cold compress (P<0.05), and also the degree of swelling on 48, 72 hours (P<0.05).From the second day after cold compress,the rate of repercussion in the experimental group was more quickly than coutrol group.The third hours of the cold compress, the temperature of mirabilite ice pack was 3~5\u2103, and it became frost water, and the temperature of ice pack was 3\u2103, it had completely melted.Conclusions The effect of cold compress of mirabilite ice pack on cooling and repercussion is better than ice pack, it could be used in the clinic extensively.",
        "keywords": [
            "Wound and injuries",
            "Cryotherapy",
            "Clinical nursing research",
            "Natrii sulfas"
        ],
        "authors": [
            {
                "name": "BAI Ya-mei",
                "org": " Department of Orthopedics,Changzhou Traditional Chinese Medicine Hospital,Jiangsu,,China"
            },
            {
                "name": "ZHANG Xi",
                "org": " Department of Orthopedics,Changzhou Traditional Chinese Medicine Hospital,Jiangsu,,China"
            },
            {
                "name": "WU Xing-biao",
                "org": " Department of Orthopedics,Changzhou Traditional Chinese Medicine Hospital,Jiangsu,,China"
            }
        ],
        "venue": "Chinese Journal of Nursing",
        "year": 2006
    },
    "dV2nAoQs": {
        "id": "dV2nAoQs",
        "title": "Combined use of TUVP and Ho:YAG laser for treatment of patients with benign prostatic hyperplasia and bladder stones",
        "abstract": "Objective To evaluate the effect and safety of transurethral vaporesection of prostate(TUVP) combined with Ho:YAG laser lithothripsy for treatment of patients with benign prostatic hyperplasia and bladder stones.Methods Twenty-four cases of benign prostatic hyperplasia(BPH) complicated with bladder stones were performed by combined TUVP with Ho:YAG laser cystolithotripsy.Results The operations were successful in all cases,no patient developed a fistula,retention of cystolith and urinary retention.Conclusion TUVP combined with Ho:YAG laser cystolithotripsy is a safe and effective methed for patients with BPH and bladder stones,especially suitable for the elder and risky patients.",
        "keywords": [
            "Bladder stone",
            "Transurethral vaporesection of prostate",
            "Ho:YAG laser",
            "Benign prostatic hyperplasia"
        ],
        "authors": [
            {
                "name": "YAO Linya",
                "org": ".Department of Urology,Branch of Kunshan Chinese Traditional Medicine Hospital,Nanjing Chinese Traditional Medicine University,Kunshan ,Jiangsu"
            },
            {
                "name": "ZENG Xueming",
                "org": ".Department of Urology,Branch of Kunshan Chinese Traditional Medicine Hospital,Nanjing Chinese Traditional Medicine University,Kunshan ,Jiangsu"
            },
            {
                "name": "WU Minghan",
                "org": ".Department of Urology,Branch of Kunshan Chinese Traditional Medicine Hospital,Nanjing Chinese Traditional Medicine University,Kunshan ,Jiangsu"
            },
            {
                "name": "HU Bing",
                "org": ".Department of Urology,Branch of Kunshan Chinese Traditional Medicine Hospital,Nanjing Chinese Traditional Medicine University,Kunshan ,Jiangsu"
            },
            {
                "name": "ZHANG Xi",
                "org": ".Department of Urology,Branch of Kunshan Chinese Traditional Medicine Hospital,Nanjing Chinese Traditional Medicine University,Kunshan ,Jiangsu"
            },
            {
                "name": "SHEN Binjin",
                "org": ".Department of Urology,Branch of Kunshan Chinese Traditional Medicine Hospital,Nanjing Chinese Traditional Medicine University,Kunshan ,Jiangsu"
            },
            {
                "name": "WANG Jun",
                "org": ".Department of Urology,Branch of Kunshan Chinese Traditional Medicine Hospital,Nanjing Chinese Traditional Medicine University,Kunshan ,Jiangsu"
            },
            {
                "name": "GAO Min",
                "org": ".Department of Urology,Branch of Kunshan Chinese Traditional Medicine Hospital,Nanjing Chinese Traditional Medicine University,Kunshan ,Jiangsu"
            }
        ],
        "venue": "Henan Journal of Surgery",
        "year": 2008
    },
    "nn8qawAp": {
        "id": "nn8qawAp",
        "title": "Analysis of efficacy of semi-rigid lumbar dynamic fixation for spondylolisthesis",
        "abstract": "Objective To evaluate the clinical efficacy of treating spondylolisthesis by semi-rigid lumbar dynamic fixation.Methods Surgical decompression and lumbar posterior semi-rigid dynamic internal fixation were performed in 32 patients with lumbar degeneration.The imaging features were followed up and ODI scores and JOA questionnaires were assessed before and after operation.Results All patients were followed up for 1 year.Compared to before,the ODI scores were decreased [(61.82\u00b110.79) points vs.(12.15\u00b15.27) points] and the JOA scores were increased after operation[(9.28\u00b11.86) points vs.(27.89\u00b11.99) points](P<0.05).There was a tendency of reversing the degeneration of the adjacent lumbar intervertebral discs.Conclusion The semi-rigid lumbar posterior dynamic internal fixation system can achieve an excellent clinical efficacy and prevent and reduce the degeneration of the adjacent lumbar intervertebral discs.",
        "keywords": [
            "Spondylolisthesis",
            "Semi-rigid lumbar posterior dynamic internal fixation system"
        ],
        "authors": [
            {
                "name": "WU Xingbiao",
                "org": ".Department of Orthopaedics,Affiliated Changzhou Hospital of Chinese Traditional Medicine,Nanjing University of Chinese Medical,Changzhou ,CHINA"
            },
            {
                "name": "ZHANG Xi",
                "org": ".Department of Orthopaedics,Affiliated Changzhou Hospital of Chinese Traditional Medicine,Nanjing University of Chinese Medical,Changzhou ,CHINA"
            },
            {
                "name": "GAO Jun",
                "org": ".Department of Orthopaedics,Affiliated Changzhou Hospital of Chinese Traditional Medicine,Nanjing University of Chinese Medical,Changzhou ,CHINA"
            }
        ],
        "venue": "Jiangsu Medical Journal",
        "year": 2011
    },
    "A8yprQ6k": {
        "id": "A8yprQ6k",
        "title": "Clinical Research of Wenshen Juanbi Decoction in the Treatment of Knee Osteoarthritis with Kidney Empty Wet Resistance Syndrome",
        "abstract": "Objective: To investigate the clinical curative effect of Wenshen Juanbi decoction in the treatment of knee osteoarthritis with kidney empty wet resistance syndrome.Methods: 200 patients can be divided into control group and treatment group according to random number table,100 cases in each group.The control group was given Jingu Tongxiao pills and the treatment group was given Wenshen Juanbi soup.Results: The effective rate was 78.35% in treatment group and 94.76% in treatment group.Compared the efficient of two groups,the difference had statistical significance(P < 0.05).Compared the Lysholm clinical grading and VAS scores of treatment group with control group the difference had statistical significance(P < 0.05).Conclusion: The curative effect of Wenshen Juanbi decoction in the treatment of knee osteoarthritis is distinct.",
        "keywords": [
            "Jingu Tongxiao pills",
            "Wenshen Juanbi soup",
            "kidney empty wet resistance syndrome",
            "knee osteoarthritis"
        ],
        "authors": [
            {
                "name": "Tao Hongming",
                "org": ""
            },
            {
                "name": "Lv Zhengxiang",
                "org": ""
            },
            {
                "name": "Zhang Xi",
                "org": ""
            },
            {
                "name": "Xia Jianlong",
                "org": ""
            }
        ],
        "venue": "China Journal of Chinese Medicine",
        "year": 2013
    },
    "xNgwyONX": {
        "id": "xNgwyONX",
        "title": "Right anterior intropleural approach,primary autograft and internal fixation for the treatment of thoracic tuberculosis with neurological deficits",
        "abstract": "Objective To investigate the effects of surgical management for thoracic tuberculosis with neurological deficits using primary bone grafting and internal fixation through right anterior intrapleural approach.Methods All cases underwent primary anterior debridement,interbody autograft and anterior internal fixation via thoracic cavity.The clinical outcome was reviewed retrospectively.Results 10 cases were followed up for 1~5 years.Neurological deficits were evaluated by ASIA score system.The results showed that there were 6 cases in C grade were restored to E grade and 2 cases in D grade to E grade after 4 weeks of operation,and 2 case in C grade to E grade after 3 months of operation.All cases healed without any recurrence and complications such as infection,respiratory failure and so on.Spinal fusion was documented in 3~8 months after surgery.Conclusions It is a safe and effective method to use right anterior intropleural approach,primary autograft and internal fixation in the management of thoracic tuberculosis associated with neurological deficits.",
        "keywords": [
            "tuberculosis",
            "thoracic vertebrae",
            "spinal",
            "internal fixation",
            "paraplegia"
        ],
        "authors": [
            {
                "name": "WU Xing-biao",
                "org": "Section \u2161,Dept of Orthopaedics,Changzhou Affiliated Hospital of Nanjing Traditional Chinese Medical University,Changzhou,Jiangsu ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "Section \u2161,Dept of Orthopaedics,Changzhou Affiliated Hospital of Nanjing Traditional Chinese Medical University,Changzhou,Jiangsu ,China"
            },
            {
                "name": "GAO Jun",
                "org": "Section \u2161,Dept of Orthopaedics,Changzhou Affiliated Hospital of Nanjing Traditional Chinese Medical University,Changzhou,Jiangsu ,China"
            }
        ],
        "venue": "Journal of Clinical Orthopaedics",
        "year": 2011
    },
    "IToYaaa6": {
        "id": "IToYaaa6",
        "title": "Study on Logistics Park Planning Based on the MSFLB Model",
        "abstract": "The paper mainly analyzes the problems in the development and planning of logistics parks,explores the procedures and methods of logistics planning in the toolbox of the MSFLB model,and then carries out a case study on the actual planning of the Pingxi logistics park.",
        "keywords": [
            "Pingxi logistics park",
            "logistics planning",
            "MSFLB model"
        ],
        "authors": [
            {
                "name": "DENG Xin-feng",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            }
        ],
        "venue": "Logistics Technology",
        "year": 2010
    },
    "D5bs9l0g": {
        "id": "D5bs9l0g",
        "title": "Assisted Decision-making for Incoming Passenger Flow Management at Urban Rail Transit Hub Stations",
        "abstract": "The paper studies systematically the layout of rail traffic hubs and the organization of passenger flows,carries out a dynamic simulation of the incoming passenger flow of the Beijing Xizhimen metro station using software Anylogic 6.4,identifies the bottlenecks holding up passen-gerflow and putsforth the countermeasures such as passenger corridor rearrangement and station facility placement optimization.",
        "keywords": [
            "passenger flow line",
            "urban rail transit hub",
            "decision-making recommendation",
            "Anylogic simulation"
        ],
        "authors": [
            {
                "name": "YU Lu",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            }
        ],
        "venue": "Logistics Technology",
        "year": 2011
    },
    "zpBIwl2G": {
        "id": "zpBIwl2G",
        "title": "Advantages of Yantai as a Logistics Hub",
        "abstract": "As has been fully demonstrated by the unique strength and logistics practice of Yantai,modern logistics industry has become a new growth factor in the takeoff of Yantai economy.The paper first analyzes the current status of the development of modern logistics industry in Yantai,points out the existing problems,in view of which,it proposes a series of countermeasures and suggestions.",
        "keywords": [
            "logistics hub",
            "Yantai",
            "logistics industry"
        ],
        "authors": [
            {
                "name": "LU Kuan",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            }
        ],
        "venue": "Logistics Technology",
        "year": 2010
    },
    "FCOAmlao": {
        "id": "FCOAmlao",
        "title": "Development of railway station signaling control equipment fault diagnosis expert system",
        "abstract": "Development and implementation of the station signaling control equipment fault diagnosis expert system are studied by the artificial intelligence and expert system methods. On the basis of the current situation of station signaling computer monitoring system, the overall structure of the station signaling equipment fault diagnosis expert system is proposed , which consists of the knowledge acquisition subsystem, equipment condition monitoring data import subsystem, knowledge base subsystem, machine reasoning subsystem, integrated database subsystem and man-machine interfacing subsystem. According to the types and characteristics of faults are established the fault mechanism analysis model based on the principle of logic circuits, the fault analysis model based on actual expert knowledge, the fault diagnosis & trend analysis model based on the equipment life mechanism and the complex fault diagnosis model based on the decision tree learning algorithm. The prototype system is developed with the object-oriented structural knowledge representation methods and the element classification development technology, thus laying a foundation for development of the practical application systems.",
        "keywords": [
            "Expert system",
            "Fault diagnosis",
            "Railway station",
            "Signaling equipment"
        ],
        "authors": [
            {
                "name": "Xi Zhang",
                "org": "Beijing Jiaotong Daxue(Beijing Jiaotong University,Northern Jiaotong University),Beijing,China"
            },
            {
                "name": "Xu Sheng Du",
                "org": "Huanan Medical Electronic Science and Technology Co,.Ltd.(Huanan Medical Electronic ScienceandTechnology Co,.Ltd.,Henan Splendor Science and Technology Co. Ltd.,Henan Huanan Medical Science and Technology Co., Ltd.,Huanan Medical Science and Technology Co., Ltd.,Huanan Medical Electronic Science and Technology Co,.Ltd.),Zhengzhou,China"
            },
            {
                "name": "LIU Chao-ying",
                "org": "Ministry of Railways of the People's Republic of China(Ministry of Railways,Ministry of Railway),Beijing,China"
            }
        ],
        "venue": "Tiedao Xuebao/Journal of the China Railway Society",
        "year": 2009
    },
    "82W3ySUI": {
        "id": "82W3ySUI",
        "title": "Research on the Establishment of\"Three-spicy\"Logistics System in Laiwu",
        "abstract": "As an important pillar to the economic development of rural Laiwu,the \"three-spicy\" products and their related issues have assumed grave importance and the establishment of \"three-spicy\" logistics system in Laiwu is a project of complex systems.In view of the existing problems therein,the paper studies the necessity and reliability for the establishment of the system and proposes the necessary theoretical guidance and decision-making support.",
        "keywords": [
            "\"three-spicy\"of Laiwu",
            "logistics system",
            "development strategy"
        ],
        "authors": [
            {
                "name": "DENG Xin-feng",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            }
        ],
        "venue": "Logistics Technology",
        "year": 2010
    },
    "kVIcMknP": {
        "id": "kVIcMknP",
        "title": "Research on optimization method for decision making point of guide sign in passenger station based on GA",
        "abstract": "For complexity of guide sign setting in large-scale passenger station, it was proposed an optimization method for the decision marking point of guide sign based on GA, and taken Beijing South Station as an example, for the actual implementation of the program, provided a reference for decision-making.",
        "keywords": [
            "Genetic Algorithm",
            "passenger station",
            "passenger traffic",
            "guide sign"
        ],
        "authors": [
            {
                "name": "HAN Yan-xin",
                "org": " College of Traffic and Transportation, Beijing Jiaotong University, Beijing , China "
            },
            {
                "name": "ZHANG Xi",
                "org": " College of Traffic and Transportation, Beijing Jiaotong University, Beijing , China "
            }
        ],
        "venue": "Railway Computer Application",
        "year": 2009
    },
    "ZoLZpDRb": {
        "id": "ZoLZpDRb",
        "title": "Study on Information Sharing in Tobacco Supply Chains Based on IOT",
        "abstract": "In this paper,we analyzed the seamless inoculation,repeated use of resources and bullwhip effect of the tobacco supply chain,discussed the demand for information sharing in the development of tobacco supply chain in China,analyzed the information sharing model of the tobacco supply chain based on IOT and formulated the mathematical model to analyze the value of information sharing in the tobacco supply chain.",
        "keywords": [
            "tobacco supply chain",
            "information sharing model",
            "IOT",
            "information sharing value"
        ],
        "authors": [
            {
                "name": "LI Te-lang",
                "org": "Beijing Jiaotong University,Beijing ;State Tobacco Monopoly Bureau,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "Beijing Jiaotong University,Beijing "
            },
            {
                "name": "CAO Wei",
                "org": "Beijing Jiaotong University,Beijing "
            }
        ],
        "venue": "Logistics Technology",
        "year": 2012
    },
    "AnXBCttN": {
        "id": "AnXBCttN",
        "title": "Study on the real-coded genetic algorithm of the empty wagons flow assignment",
        "abstract": "Taking account of the complexity of the solution of empty wagon flow assignment optimization, the paper puts forward an intelligent optimized method-Real-coded Genetic Algorithm (RGA). It deals with the basic structure of RGA and formation of individual and fitness function, analyzes the basic characteristics of the algorithm and designs the genetic seed. Finally, this paper uses an example of empty wagon flow assignment to test the effectiveness of the algorithm.",
        "keywords": [
            "Empty wagons flow assignment",
            "Genetic algorithms",
            "Real-coded"
        ],
        "authors": [
            {
                "name": "Xi Zhang",
                "org": "Beijing Jiaotong Daxue(Beijing Jiaotong University,Northern Jiaotong University),Beijing,China"
            },
            {
                "name": "ZHANG Quan-shou",
                "org": "Beijing Jiaotong Daxue(Beijing Jiaotong University,Northern Jiaotong University),Beijing,China"
            }
        ],
        "venue": "Xitong Gongcheng Lilun yu Shijian/System Engineering Theory and Practice",
        "year": 2006
    },
    "b1PIzevZ": {
        "id": "b1PIzevZ",
        "title": "Research on integrated optimization model of city bus operation plan",
        "abstract": "Reasonable formulating urban bus operation plan was an important means to raise the level of public transport services and the efficiency of vehicle resources. Facing with the complexity of city bus operation plan, it was established an integrated multi-objective optimization model which met the feature of flow space-time distribution and the effectiveness of enterprise, discussed and analysised integrated optimization model combined with traditional empirical formula, achieved satisfactory results.",
        "keywords": [
            "adjustment",
            "operation plan",
            "optimization model",
            "flow space-time distribution"
        ],
        "authors": [
            {
                "name": "QIN Li-jiao",
                "org": "School of Traffic and Transportation, Beijing Jiaotong University, Beijing , China"
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic and Transportation, Beijing Jiaotong University, Beijing , China"
            }
        ],
        "venue": "Railway Computer Application",
        "year": 2008
    },
    "RRk4shRU": {
        "id": "RRk4shRU",
        "title": "Application of Improved Genetic Algorithm in Vehicle Routing Problem",
        "abstract": "The mathematical model of Vehicle Routing Problem is developed in this paper.To improve the search rate of genetic algorithm and avoid the premature phenomenon of population,an improved genetic algorithm,in which the fitness function is defined with dynamic linear method and its cross-operator is improved to adopt a large variation of operation for Vehicle Routing Problem,is designed,and the detailed computation steps of the genetic algorithm are given.Finally,the genetic algorithm is applied to a numerical example.The results indicate that the genetic algorithm is better than the genetic algorithm designed in the existing reference literature over the computational performance.Furthermore,the improved strategies of the genetic algorithm are not only simple but also effective in solving the Vehicle Routing Problem.",
        "keywords": [
            "dynamic linear method",
            "genetic algorithm",
            "large variation operation",
            "VRP",
            "improved cross-operator"
        ],
        "authors": [
            {
                "name": "ZHANG Huaqing",
                "org": "School of Traffic and Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic and Transportation,Beijing Jiaotong University,Beijing ,China"
            }
        ],
        "venue": "Journal of Transport Information and Safety",
        "year": 2012
    },
    "6z4rqfep": {
        "id": "6z4rqfep",
        "title": "Research on Evaluation Method of Urban Road Intersection Improved Schemes",
        "abstract": "Comprehensive evaluation index system of improved schemes is established and AHP model and method are put forward according to complexity of urban road intersection.Quantitative and qualitative methods are applied to evaluation criteria and grading standards.A specific example is analyzed about improved schemes on the intersection of Beijing Jiaotong University east road and College south road.At the same time,simulation assessment validation is adopted to improve schemes of intersection by VISSIM.",
        "keywords": [
            "improved schemes",
            "intersection",
            "evaluation system",
            "evaluation index",
            "VISSIM"
        ],
        "authors": [
            {
                "name": "Yu Lu",
                "org": "School of Traffic and Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "Zhang Xi",
                "org": "School of Traffic and Transportation,Beijing Jiaotong University,Beijing ,China"
            }
        ],
        "venue": "Modern Transportation Technology",
        "year": 2011
    },
    "oFcC5F9p": {
        "id": "oFcC5F9p",
        "title": "Study on the Passenger Flow Distribution Pattern of Large-scale Passenger Stations",
        "abstract": "Through in-depth analysis of the departure-arrival characteristics of the Beijing South station obtained throug field investigation and statistical analysis,the paper uncovers its arrival and departure pattern,paving the foundation for the passenger flow simulation of large-scale passenger stations.",
        "keywords": [
            "fitting of distribution",
            "passenger flow distribution",
            "arrival pattern",
            "departure pattern"
        ],
        "authors": [
            {
                "name": "LIANG Ying-hui",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHENG Pan",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            }
        ],
        "venue": "Logistics Technology",
        "year": 2010
    },
    "W0Wy0KmA": {
        "id": "W0Wy0KmA",
        "title": "SWOT Analysis of Chinese Small-and-Medium-Sized Enterprises' International Competition and Development Strategies",
        "abstract": "The paper analyzes the strength and weakness of Chinese SMS enterprises in international competition as well as the opportunities and threats they face,introduces the SWOT quantitative analytic model,based on which,the development strategies of the enterprises are proposed,and,at the end,lists the development strategies that are viable for selection.",
        "keywords": [
            "SWOT analysis",
            "international competition",
            "development strategy",
            "small-and-medium-sized enterprise"
        ],
        "authors": [
            {
                "name": "ZHANG Yan-fen",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            }
        ],
        "venue": "Logistics Technology",
        "year": 2011
    },
    "FbfNnbDT": {
        "id": "FbfNnbDT",
        "title": "Study on classification of service level of free traveling interval in large-sized passenger terminals",
        "abstract": "This paper analyzed the problems of the service level in large-sized passenger terminals,pointed out the factors which influenced the classification of service level for passenger services.The simulation study was carried out to free traveling interval by software Legion.Combing with the coefficient of self-organization,it was determined the classification standards for service level of free traveling interval.",
        "keywords": [
            "free traveling interval",
            "coefficient of self-organization",
            "service level",
            "large-sized passenger terminal"
        ],
        "authors": [
            {
                "name": "DENG Xin-feng",
                "org": "School of Traffic and Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "XING Yun-lei",
                "org": "School of Traffic and Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic and Transportation,Beijing Jiaotong University,Beijing ,China"
            }
        ],
        "venue": "Railway Computer Application",
        "year": 2011
    },
    "i7wBqlQA": {
        "id": "i7wBqlQA",
        "title": "Study on the Fuzzy Neural Network Model for At-grade Intersection Motor-bicycle Conflict",
        "abstract": "The paper classifies the at-grade intersections into three groups in terms of conflict occurrence and seriousness using fuzzy clustering method.In an empirical study,it applies the procedure to the at-grade intersections of Ganjiakou district of Beijing and then chooses the intersections with the most serious conflicts as the study object of the paper.It first analyzes the safety hazards that could lead to conflicts and then studies quantitatively the motor-bicycle conflict failure tree of the intersections,on the basis of which a fuzzy neural network model for the conflicts is set up.The model can identify the causes of a conflict as it happens and at the end,an empiricaly study is carried out to verify the validity of the model.",
        "keywords": [
            "failure tree",
            "fuzzy neural network",
            "urban traffic",
            "motor-bicycle conflict",
            "at-grade intersection"
        ],
        "authors": [
            {
                "name": "LIANG Ying-hui",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHENG Pan",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            }
        ],
        "venue": "Logistics Technology",
        "year": 2011
    },
    "ykp68fqS": {
        "id": "ykp68fqS",
        "title": "System dynamics model of post-evaluation on railway investment and example analysis",
        "abstract": "The railway construction investment was huge. Feasibility study and post evaluation were both essential. So it could be assessed the expectation target of investment, put forward excellent suggestion, and provided science theory for the future new investment. It was put forward the system dynamics model of the post evaluation to railway investment benefits by simulation software Vensim7.0, and proved the validity of the proposed model. Then it was studied the Jingjiu railway\u2019s investment with with/without method, taken the Jiangxi Province as a example.",
        "keywords": [
            "system dynamic model",
            "analysis",
            "post evaluation",
            "investment"
        ],
        "authors": [
            {
                "name": "LIU Min-wei",
                "org": "School of Traffic and Transportation, Beiing Jiaotong University, Beijing , China "
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic and Transportation, Beiing Jiaotong University, Beijing , China "
            }
        ],
        "venue": "Railway Computer Application",
        "year": 2008
    },
    "YLbAMZzA": {
        "id": "YLbAMZzA",
        "title": "Strategy for the Development of Modern Railway Logisics",
        "abstract": "The paper analyzes the current status of railway freight transportation,explains the necessity for the development of modern railway logistics,and gives countermeasures for existing deficiencies.",
        "keywords": [
            "railway transport",
            "modern logistics",
            "strategy"
        ],
        "authors": [
            {
                "name": "XUE Yan-qing",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            }
        ],
        "venue": "Logistics Technology",
        "year": 2011
    },
    "MP9Q3nzu": {
        "id": "MP9Q3nzu",
        "title": "Analysis of Dynamic Simulation and Evaluation of Passenger Flow Organizations in Large-scale Railway Stations",
        "abstract": "This paper develops a dynamic simulation model based on AnyLogic software,and designs its assumptions,core algorithms,evaluation indexes and modeling process.Then,an example is analyzed by using an AnyLogic dynamic simulation model.Furthermore,the root of bottleneck which restricts passenger flow organizations is found out and an optimized scheme is put forward.The results indicate that AnyLogic software is feasible when it is applied to the dynamic simulation and evaluation of passenger flow organizations in large-scale railway stations.",
        "keywords": [
            "railway station",
            "simulation",
            "passenger flow organization",
            "evaluation"
        ],
        "authors": [
            {
                "name": "WANG Yanjie",
                "org": "School of Traffic and Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic and Transportation,Beijing Jiaotong University,Beijing ,China"
            }
        ],
        "venue": "Journal of Transport Information and Safety",
        "year": 2013
    },
    "K9cH5z62": {
        "id": "K9cH5z62",
        "title": "Analysis on optimizations of passenger flow organizations in Beijing South Station based on Anylogic simulation",
        "abstract": "Aimed at the complexity of passenger organizations in the ground floor of Beijing South Station,according to the characteristics of function location layout and passenger flow distribution,it was analyzed and simulated the passenger flow of the ground floor of Beijing South Station by Anylogic micro-dynamic simulation software,set up a dynamic simulation environment model of passenger flow organization and designed a simulation process and evaluation index system.Based on the analysis of multi-index for the congestion bottleneck distribution of passenger flow within the Station,the queue length and waiting time,etc,put forward practical operation optimization scheme of the reasonable disposition and management of the customer service equipment(such as inspection ticketing system equipment,safety inspection system equipment,transfer channel service equipment,etc.),provided the basis for decision of practical operation management.",
        "keywords": [
            "Beijing South Station",
            "analysis",
            "Anylogic simulation",
            "passenger flow organization"
        ],
        "authors": [
            {
                "name": "XUE Yan-qing",
                "org": "School of Traffic and Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic and Transportation,Beijing Jiaotong University,Beijing ,China"
            }
        ],
        "venue": "Railway Computer Application",
        "year": 2012
    },
    "AsOWxjqc": {
        "id": "AsOWxjqc",
        "title": "Research on corresponded configuration scheme of railway large-scaled comprehensive transport passenger stations transmit ability",
        "abstract": "Aimed at the actual need of railway large-scaled comprehensive transport passenger stations management, it was established the transfer transmit ability corresponded configuration model between the different transport modes.Using this model, it was appraised and analyzed the harmony of transfer transmit ability on the Beijing south large-scaled comprehensive transport passenger railway stations, and put forward the rational configuration scheme of the transfer transmit ability between the city railway traffic, the city public traffic, the city taxi traffic ,the traffic of the car from society and the railway transport of different citis.",
        "keywords": [
            "corresponded configuration model",
            "railway large-scaled passenger stations",
            "transfer transmit ability",
            "transmit ability configuration scheme"
        ],
        "authors": [
            {
                "name": "LIANG Ying-hui",
                "org": "School of Traffic and Transportation, Beijing Jiaotong University, Beijing , China"
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic and Transportation, Beijing Jiaotong University, Beijing , China"
            }
        ],
        "venue": "Railway Computer Application",
        "year": 2009
    },
    "NC9INP3i": {
        "id": "NC9INP3i",
        "title": "Analysis coordinated city traff park and rade capacity for passenger stations of railways high-speed",
        "abstract": "In this paper,aimed at South Station during the peak period of transport to coordinate the various traffic analysis problem,by rail,subway and bus transportation could be used to match the model set up,that rail and subway,rail and bus commonly used in transport capacity matching programs,as well as vehicle grouping plans,departure time interval,such as transport organization configuration.For example of Beijing South Station mode,it was analyzed transportation for operation and management of the proposed basis for decision making.",
        "keywords": [
            "large-scale comprehensive transportation hub",
            "traffic coordination",
            "match degree"
        ],
        "authors": [
            {
                "name": "FENG Shu-xia",
                "org": "School of Traffic and Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic and Transportation,Beijing Jiaotong University,Beijing ,China"
            }
        ],
        "venue": "Railway Computer Application",
        "year": 2010
    },
    "RRchwCF0": {
        "id": "RRchwCF0",
        "title": "Analysis on pedestrian crossing behavior at signalized intersection based on computer simulation",
        "abstract": "This paper analyzed on the importance of factors that could impact pedestrian crossing behavior under the red light.Then conducted a survey in the standard intersections of Beijing to get the data through questionnaires methods,established a Logit regression model based on different affecting factors of pedestrian behavior,with the model parameter calibration and validation.The results showed that transportation information factor,personal factor,psychological factor as well as constraint factor played a significant role on pedestrian's behavior.The conclusion was good for the guide to the pedestrian traffic planning and management.",
        "keywords": [
            "questionnaire survey",
            "Logit regression model",
            "influencing factor",
            "pedestrian crossing behaver"
        ],
        "authors": [
            {
                "name": "GUO Jian-hong",
                "org": "School of Traffic and Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic and Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "HAN Yu",
                "org": "School of Traffic and Transportation,Beijing Jiaotong University,Beijing ,China"
            }
        ],
        "venue": "Railway Computer Application",
        "year": 2012
    },
    "iXEIrlP6": {
        "id": "iXEIrlP6",
        "title": "Design and implementation of knowledge database for Diagnose Expert System of railway station signal equipment",
        "abstract": "According to the goal in the Diagnose Expert System for railway station signal equipment,it was adopted object-orient structural knowledge representation in the design and implementation of knowledge database for Diagnose Expert System.It was analyzed the constitution of object-orient knowledge representation and its features.Meanwhile,by the concrete example,it was also explained the designing and implementing method for original knowledge database.After the actual operation in this expert system,It was find that object-orient technique not only enhanced the representation in expert knowledge,but also benefited the organization for expert knowledge.",
        "keywords": [
            "object-orient",
            "knowledge representation",
            "fault diagnose",
            "railway station signal equipment",
            "Expert System"
        ],
        "authors": [
            {
                "name": "CUI Li-na",
                "org": "School of Traffic and Transportation of Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic and Transportation of Beijing Jiaotong University,Beijing ,China"
            }
        ],
        "venue": "Railway Computer Application",
        "year": 2005
    },
    "YXmCLXpV": {
        "id": "YXmCLXpV",
        "title": "Application of ACA-based Data Mining in TPL",
        "abstract": "In this paper,we introduced the basic principle of the ant colony algorithm,used the data mining method based on it to optimize the route of logistics distribution in a case study and demonstrated the effectiveness of the algorithm.",
        "keywords": [
            "data mining",
            "logistics distribution route",
            "ant-colony algorithm",
            "TPL"
        ],
        "authors": [
            {
                "name": "GUO Jian-hong",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            }
        ],
        "venue": "Logistics Technology",
        "year": 2012
    },
    "WGy3LR3b": {
        "id": "WGy3LR3b",
        "title": "Study on risk assessment of large passenger stations based on set valued set-valued statistical method",
        "abstract": "It was analyzed the risk factors which would incur emergencies in the railway large passenger stations,proposed the risk assessment model based on set-valued statistical method.The model was used to study on the fire emergency of Beijing South Railway Station.",
        "keywords": [
            "risk factors analysis",
            "weight",
            "risk assessment",
            "set-valued statistical method"
        ],
        "authors": [
            {
                "name": "XING Yun-lei",
                "org": "School of Traffic and Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic and Transportation,Beijing Jiaotong University,Beijing ,China"
            }
        ],
        "venue": "Railway Computer Application",
        "year": 2010
    },
    "4MCUzurs": {
        "id": "4MCUzurs",
        "title": "Study on Solution of TSP Based on Improved Genetic Algorithm",
        "abstract": "In this paper we proposed an improved genetic algorithm to solve the traveling salesperson problem and introduced in detail the main improved aspects: using the greedy algorithm to construct the initial population in order to improve the speed to obtain the near-optimized solutions;combining the optimum preservation strategy with the roulette method;carrying out cross-over operation with two-point three-section random crossing method to keep the diversity of the population and avoid prematurity.Then in a TSP experiment with 144 Chinese cities,we demonstrated the good performance of the algorithm.",
        "keywords": [
            "TSP",
            "genetic algorithm",
            "two-point three section random crossing",
            "greedy algorithm"
        ],
        "authors": [
            {
                "name": "ZHOU Ze-yan",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            }
        ],
        "venue": "Logistics Technology",
        "year": 2012
    },
    "P3AipGNN": {
        "id": "P3AipGNN",
        "title": "Exploration of Logistics System of Wal-Mart China",
        "abstract": "The paper introduces the advantages of the Wal-Mart logistics system in the U.S.,analyzes the problems it runs into in its migration to China,and offers corresponding countermeasures.",
        "keywords": [
            "Wal-Mart",
            "distribution center",
            "distribution"
        ],
        "authors": [
            {
                "name": "ZHANG Shuai",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic & Transportation,Beijing Jiaotong University,Beijing ,China"
            }
        ],
        "venue": "Logistics Technology",
        "year": 2011
    },
    "v0ZVPisv": {
        "id": "v0ZVPisv",
        "title": "Optimization algorithm for sign-oriented identification system of high-speed railway terminal",
        "abstract": "The high-speed railway development proposes higher requirement for sign-oriented identification system of high-speed railway terminal. To offer passengers more convenient and efficient services, the paper designs the passengers guiding sign optimization system by intelligent optimization algorithms with consideration of the complex station locations and actual demand of operation and management. First, it proposes the passenger guides choice of location model with the goal of maxmum inductive information of a region. Second, it uses the anneal-genetic algorithm to solve the model and find the superior stationing position. Finally, it studies the case of basement storey 1 in Beijing Southern Station. The obtained results are compared with that of the genetic algorithm to verify the feasibility and validity of anneal-genetic algorithm. It has provides scientific basis for the optimization design of sign-oriented identification system of high-speed railway terminal.",
        "keywords": [
            "Anneal-genetic algorithm",
            "Passenger transport terminal",
            "Sign-oriented identification",
            "System optimization",
            "Systems engineering"
        ],
        "authors": [
            {
                "name": "LIANG Ying-hui",
                "org": "Beijing Jiaotong Daxue(Beijing Jiaotong University,Northern Jiaotong University),Beijing,China"
            },
            {
                "name": "Xi Zhang",
                "org": "Beijing Jiaotong Daxue(Beijing Jiaotong University,Northern Jiaotong University),Beijing,China"
            },
            {
                "name": "HAN Yan-xin",
                "org": "Beijing Jiaotong Daxue(Beijing Jiaotong University,Northern Jiaotong University),Beijing,China"
            }
        ],
        "venue": "Jiaotong Yunshu Xitong Gongcheng Yu Xinxi/Journal of Transportation Systems Engineering and Information Technology",
        "year": 2011
    },
    "cCqvM5J1": {
        "id": "cCqvM5J1",
        "title": "Research on a Vensim simulation based prediction method of urban vehicle fuel consumption",
        "abstract": "Correct prediction of fuel consumption of urban cars has great significance to scientifically evaluate urban traffic environment pollution and even to formulate the relevant policies.This paper constructs the causal diagram and system flow chart of urban car fuel consumption with the theory and method of system dynamics.We quantify the factors influencing fuel consumption and present a predictive model.We eventually analyze fuel consumption of Beijing as a concrete example and verify its correctness with simulation software,Vensim.",
        "keywords": [
            "system dynamics",
            "urban car",
            "predictive model",
            "fuel consumption"
        ],
        "authors": [
            {
                "name": "HAN Yu",
                "org": "School of Traffic and Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic and Transportation,Beijing Jiaotong University,Beijing ,China"
            }
        ],
        "venue": "Shandong Science",
        "year": 2012
    },
    "P7O0PuNR": {
        "id": "P7O0PuNR",
        "title": "Analysis on dynamic simulation for passenger flow line organizations and optimizations in Beijing South Railway Station",
        "abstract": "Aimed at the complexity of passenger transfer organizations in the elevated layer of Beijing South Railway Station,it was analyed and designed the transferring passenger flow,set up a dynamic simulation model about passenger flow organization,by using VISSIM micro-dynamic simulation software,put forward a more reasonable optimized program of transfer flow organization,provided a reference of decision-making for the actual operation and management.",
        "keywords": [
            "Beijing South Railway Station",
            "passenger organization",
            "dynamic simulation",
            "optimization"
        ],
        "authors": [
            {
                "name": "ZHANG Su-fang",
                "org": "School of Traffic and Transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "School of Traffic and Transportation,Beijing Jiaotong University,Beijing ,China"
            }
        ],
        "venue": "Railway Computer Application",
        "year": 2010
    },
    "nKiZLCyn": {
        "id": "nKiZLCyn",
        "title": "Simulation of Pedestrian Evacuation Based on a Dynamic Parameters Model",
        "abstract": "A dynamic parameters model is presented based on cellular automata.The dynamic parameters: direction-parameter,empty-parameter and cognition-parameter are formulated to simplify tactically the decision-making process of pedestrians,which can reflect the pedestrian judgment on the surrounding conditions and decide the pedestrian's choice of action.Simulation of pedestrian evacuation and pedestrian moving rules are established,according to two-dimensional cellular automaton Moore neighborhood.The simulation results of the improved and previous models are compared and analyzed.In the improved model,the impact of the pedestrian density around exits in evacuation is considered,the simulation results prove that this improvement makes sense.At the same time,the effects of pedestrian distribution,pedestrian density and exits width on the evacuation time are discussed,giving the optimal exit layout.The improvement of the CA model is useful for further study,it is instructional significant for pedestrian evacuation,avoiding or reducing the number of injuries.",
        "keywords": [
            "traffic engineering",
            "direction-parameter",
            "cognitionparameter",
            "pedestrian evacuation",
            "cellular automata",
            "evacuation time",
            "empty-parameter"
        ],
        "authors": [
            {
                "name": "LI Te-lang",
                "org": ""
            },
            {
                "name": "ZHANG Xi",
                "org": ""
            },
            {
                "name": "ZHU Nuo",
                "org": ""
            },
            {
                "name": "CAO Wei",
                "org": ""
            },
            {
                "name": "ZHENG Pan",
                "org": ""
            }
        ],
        "venue": "Journal of Transportation Systems Engineering and Information Technology",
        "year": 2013
    },
    "npDlNGcv": {
        "id": "npDlNGcv",
        "title": "Transport co-ordination fuzzy comprehensive evaluation analysis of Beijing South Railway Station",
        "abstract": "By analyzing Transport Co-ordination of the Beijing south railway station passenger hub in the status,it was confirmed the main factors that affected the transport co-ordination of the city large-scale hub,then set up the evaluation index system of the major city hub transport co-ordination,and using the AHP to determine the target system in all levels of the weight factors.On this basis,by using fuzzy comprehensive evaluation method,it was assessed the transport co-ordination of Beijing South Railway Station.",
        "keywords": [
            "transport co-ordination",
            "Analytical Hierarchy Process",
            "fuzzy evaluation",
            "passenger terminal"
        ],
        "authors": [
            {
                "name": "WANG Meng",
                "org": "College of traffic and transportation,Beijing Jiaotong University,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "College of traffic and transportation,Beijing Jiaotong University,Beijing ,China"
            }
        ],
        "venue": "Railway Computer Application",
        "year": 2009
    },
    "RvzfMc3G": {
        "id": "RvzfMc3G",
        "title": "THE STUDIES ON THE TEMPERATURE SENSITIVE OF N-ISOPROPYLACRYLAMIDE COPOLYMER",
        "abstract": "The thermosensitive water-soluble copolymers P(AM-NIPA) of acrylamide(AM) and N-isopropylacrylamide(NIPA) were synthesized by free radical aqueous solution copolymerization,and the ionic copolymer P(AM-NIPA-NaAA) was prepared by incorporating the third monomer sodium acrylic acid(NaAA) to the molecule structure of P(AM-NIPA).The thermosensitive mechanism of copolymer solution was studied by the fluorescence Spectrum and intrinsic viscosity.The result shows that the proportion of monomer and monomer amount in the copolymer has notable effect on the low critical solution temperature(LCST) of the copolymer solution.The LCST of copolymer solution increases with the content of AM or AA in the copolymer.When the temperature of copolymer solution reaches to the low critical solution temperature,the polarity of media around the pyrene probe decreases sharply,which causes the congregating of the hydrophobic structure of the copolymer.Molecule chains of polymer take place desolvent,which causes shrink of clew in the rare solvent of copolymer and phase separate in the dense solvent of copolymer due to congregating of copolymer.",
        "keywords": [
            "LCST",
            "temperature sensitive polymer",
            "N-isopropylacrylamide copolymer"
        ],
        "authors": [
            {
                "name": "ZHOU Li",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratoryof Polymer Materials Engineering of China,Chengdu ,China"
            },
            {
                "name": "LU Zhi-yong",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratoryof Polymer Materials Engineering of China,Chengdu ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratoryof Polymer Materials Engineering of China,Chengdu ,China"
            },
            {
                "name": "DAI Hua",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratoryof Polymer Materials Engineering of China,Chengdu ,China"
            }
        ],
        "venue": "Polymer Materials Science & Engineering",
        "year": 2006
    },
    "Sdyl1lOs": {
        "id": "Sdyl1lOs",
        "title": "Preparation and properties of anti-hydrolyzing super absorbent resin P(AMPS+AA)",
        "abstract": "The resin noted as P(AMPS+AA) is synthesized by using 2-acrylamide-2-methylpropyl sulfonic acid(AMPS),acrylic acid(AA),sodium dodecyl benzene sulfonate(LAS) as raw materials,DVB and NMBA as crosslinkers.The effects of the mass ratios of AMPS/AA,neutralizationg,crosslinker type and its dosage,and LAS dosage were investigated.The results show that the AMPS unit introduced into the polyacrylate absorbent resin can improve the salt resistance.The LAS dosage exerts obvious effects on the property of the resin preparied by adopting DVB as crosslinker.The resin shows good water absorbency when the amount of DVB and LAS are 0.3-0.45% and 0.15-0.3%.The DVB cross-linked resin displays excellent hydrolytic stability under the alkaline/acid condition at high temperature,which is better than that of the NMBA cross-linked resin.",
        "keywords": [
            "super absorbent resin",
            "2-acrylamide-2-methylpropyl sulfonic acid",
            "divinylbenzene",
            "hydrolytic stability"
        ],
        "authors": [
            {
                "name": "XIE Jing-si",
                "org": "State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu ,China"
            },
            {
                "name": "DAI Hua",
                "org": "State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu ,China"
            },
            {
                "name": "DONG Hai-ya",
                "org": "State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu ,China"
            },
            {
                "name": "JIANG Xian-cai",
                "org": "State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Chemical Research and Application",
        "year": 2010
    },
    "8hgl27Rl": {
        "id": "8hgl27Rl",
        "title": "Research Progress in the Thermal Degradation of Poly (vinyl alcohol) and Modifications for Thermoplastic Processing",
        "abstract": "Poly(vinyl alcohol)(PVA) is one of the most popular water-soluble polymers and has manifested good film forming properties,gas barrier properties,mechanical properties and biodegradability.Therefore,PVA has been widely used as textile,film,adhesive and so on.Because the decomposition temperature of PVA is close to its melting temperature,which makes the thermal degradation undergoes simultaneously during melting,the thermoplastic processing of PVA is difficult to achieve.It is necessary to modify PVA so as to realize the thermoplasticizing of this resin.The common used modifying methods include chemical modification,physical modification and blending with other polymeric materials.The article summarized the reasearch progress in the thermal degradation behaviors of PVA and the methods of modification of PVA to realize thermoplastic processing.",
        "keywords": [
            "Poly(vinyl alcohol)",
            "Thermoplastic processing",
            "Thermal degradation",
            "Plasticizing"
        ],
        "authors": [
            {
                "name": "JIANG Xian-cai",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute,Sichuan University,Chengdu ,China"
            },
            {
                "name": "DONG Hai-ya",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute,Sichuan University,Chengdu ,China"
            },
            {
                "name": "XIE Jing-si",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute,Sichuan University,Chengdu ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute,Sichuan University,Chengdu ,China"
            },
            {
                "name": "DAI Hua",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Polymer Bulletin",
        "year": 2010
    },
    "IkyvJNHi": {
        "id": "IkyvJNHi",
        "title": "Melt Processing of PVA with Magnesium Chloride and Polyethylene Glycol as the Complex Plasticizer",
        "abstract": "Poly(vinyl alcohol)(PVA) samples were prepared through the melt processing by employing magnesium chloride and polyethylene glycol(PEG) as the complex plasticizer.The interaction between the complex plasticizer and PVA was investigated by Fourier transform infrared spectroscopy(FTIR).The influences of the complex plasticizer on the crystalline and thermal properties were studied by X-ray diffraction(XRD),differential scanning calorimetry(DSC) and thermogravimetric analysis(TGA),respectively.The results show that the plasticizer can effectively destroy the hydrogen bonding between PVA molecules.The crystallinity of PVA decreased rapidly with the addition of the complex plasticizer.Thermal measurements show that the melting point(T m) of PVA decreases,the thermal stability improves and thus the thermal processing of PVA are achieved.The obtained PVA film shows good mechanical property,with the tensile strength of 31 MPa and the elongation at break of 466%.",
        "keywords": [
            "Complex plasticizer",
            "Poly(vinyl alcohol)",
            "Mechanical property",
            "Polyethylene glycol",
            "Magnesium chloride hexahydrate"
        ],
        "authors": [
            {
                "name": "JIANG Xian-cai",
                "org": ""
            },
            {
                "name": "SONG Jie",
                "org": ""
            },
            {
                "name": "JIANG Ting",
                "org": ""
            },
            {
                "name": "DAI Hua",
                "org": ""
            },
            {
                "name": "ZHANG Xi",
                "org": ""
            }
        ],
        "venue": "Chemical Journal of Chinese Universities",
        "year": 2013
    },
    "RowV8dA0": {
        "id": "RowV8dA0",
        "title": "Separation and characterization of graft copolymer from eucalyptus calcium lignosulfonate and acrylic acid",
        "abstract": "Graft copolymerization of eucalyptus calcium lignosulfonate (HLS-Ca) with acrylic acid (AA) was carried out using Fenton regent as a redox initiator. The separation efficiently of traditional precipitation-soxhlet extraction method was investigated, and a new centrifugal separation-combined with soxhlet extraction method was proposed. The chemical structures of HLS-Ca and the graft polymer (HLS-AA) were characterized by FT-IR, UV and 1H-NMR. The results showed that compared with traditional method, the new separation method is more effective to separate the graft polymer from homopolymer and unreacted HLS-Ca. The band at 1727 cm-1 in FT-IR spectrum is assigned to carbonyl absorption; the stronger absorbed band at 210 nm in the UV spectrum can be observed in HLS-AA and the signals between 10 and 14, assigned to the absorption for carboxyl hydrogen, also can be observed in the 1H-NMR spectrum of HLS-AA.",
        "keywords": [
            "Acrylic acid",
            "Eucalyptus calcium lignosulfonate",
            "Graft copolymer",
            "Separation method",
            "Structure characterizations"
        ],
        "authors": [
            {
                "name": "Dezhan Ye",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Chao Xia",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Hua Dai",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xi Zhang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Zhongguo Zaozhi Xuebao/Transactions of China Pulp and Paper",
        "year": 2013
    },
    "NTtqyH0a": {
        "id": "NTtqyH0a",
        "title": "Study on the Aqueous Solution Properties of Temperature-Sensitive Water-Soluble Polymer P(NIPAM-HEMA-AM) and P(NIPAM-HEMA-AM-AA)",
        "abstract": "The temperature-sensitive water-soluble polymer based on N-isopropylacrylamide(NIPAM) and Hydroxyethyl Methacrylate(HEMA) were synthesized by free radical aqueous solution copolymerization.And the effects of inorganic salt and polymer structure on LCST of polymer solution were investigated.Furthermore,the influences of polymer concentration,salt concentration and surfactant concentration on the rehological properties,especially the viscosity-temperature property,of polymer solution were studied.The results show that the LCST of the polymer solution declines as increasing the concentration of NaCl,CaCl2 and Na2SO4 respectively.When the polymer concentration is higher than a certain one,the viscosity of polymer solution is prominently dependented on the temperature.The addition of NaCl results in the viscosity enhancement of polymer solution,especially the temperature of the polymer solution beyond the LCST.",
        "keywords": [
            "low critical soluble temperature",
            "hydroxyethyl methacrylate",
            "water-soluble polymer",
            "N-isopropylacrylamide",
            "rehology"
        ],
        "authors": [
            {
                "name": "ZHANG Xiao-fei",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Materials Engineering of China,Chengdu ,China"
            },
            {
                "name": "ZHOU Li",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Materials Engineering of China,Chengdu ,China"
            },
            {
                "name": "ZHU Li",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Materials Engineering of China,Chengdu ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Materials Engineering of China,Chengdu ,China"
            },
            {
                "name": "DAI Hua",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Materials Engineering of China,Chengdu ,China"
            }
        ],
        "venue": "Polymer Materials Science & Engineering",
        "year": 2007
    },
    "FNIoijEo": {
        "id": "FNIoijEo",
        "title": "Graft polymers of eucalyptus lignosulfonate calcium with acrylic acid: synthesis and characterization.",
        "abstract": "The graft copolymerization of eucalyptus lignosulfonate calcium (HLS-Ca) from hardwood and acrylic acid (AA) was investigated by using Fenton agent as a coinitiator. The influences of reaction conditions on grafting parameters i.e. product yield (Y%), AA conversion (C%), grafting ratio (G%) and grafting efficiency (GE%) were carefully studied. The effects of the phenolic hydroxyl (Ph-OH) group on the polymerization of AA and grafting reaction were researched. Graft copolymers were identified by the new absorption at 1,727 cm(-1), more homogenized morphology and higher decomposition temperature after grafted with AA, as illustrated in FTIR, SEM and TG spectra. The optimum synthesis conditions are as follows: H2O2=25.2 mol/L, FeCl2=63.0 mol/L, T=50\u00b0C and t=2h and the optimum percentages of Y, C, G and GE are 97.61%, 95.23%, 71.29% and 78.85%, respectively. The Ph-OH group of HLS-Ca cannot inhibit the polymerization of AA and is involved in the grafting reaction as an active center.",
        "keywords": [
            "acrylic acid",
            "grafting reaction",
            "hardwood lignosulfonate",
            "phenolic hydroxyl group"
        ],
        "authors": [
            {
                "name": "De-Zhan Ye",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xian-Cai Jiang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Chao Xia",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xi Zhang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Carbohydrate polymers",
        "year": 2012
    },
    "RWFahKap": {
        "id": "RWFahKap",
        "title": "Studies on properties of PVA film plasticized with mixture of urea/ethanolamine",
        "abstract": "Modified PVA films were prepared by casting method using urea/ethanolamine as a mixed plasticizer. The interactions between urea/ethanolamine and PVA molecules were investigated by FTIR spectra. The crystallinity of plasticized PVA film was measured by X-ray diffraction (XRD) method. T m of modified PVA films was studied by differential scanning calorimetry ( DSC ). The mechanical properties of modified PVA films were studied by tensile testing. It was found that ethanolamine could prevent urea separating out from PVA and urea/ethanolamine mixture was a good plasticizer for PVA. FTIR spectra show that no significant structure difference between PVA and modified PVA, indicating that no chemical reaction happened between PVA and urea/ethanolamine. The shift of wavenumber shows that urea/ethanolamine can decrease the extent of inter- or intramolecular hydrogen bonds in PVA molecules. The XRD investigations show that the crystalline fraction significantly reduces with the addition of urea/ethanolamine. DSC shows that addition of urea/ethanolamine can reduce the T m of PVA film. T m of PVA film with 30 phr urea/ethanolamine can reduce to 199. 3\u00b0C. Modified PVA films show lower degree of swelling but higher solubility than that of pure PVA film. Urea/ethanolamine mixture can soften the PVA film, resulting in lower tensile strength and higher elongation at break. The tensile strength and elongation at break for PVA film modified with 30 phr urea/ethanolamine were 23. 89 MPa and 542. 88%, respectively.",
        "keywords": [
            "Ethanolamine",
            "Plasticization",
            "Poly( vinyl alcohol)",
            "Urea"
        ],
        "authors": [
            {
                "name": "Xiancai Jiang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wenping Xu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yandong Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xi Zhang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Hua Dai",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Acta Polymerica Sinica",
        "year": 2010
    },
    "rZ1orkWI": {
        "id": "rZ1orkWI",
        "title": "Synthesis and Solution Behavior of Acrylamide-4-tert-Butylstyrene-4-Vinylbenzenesulfonate Terpolymer PAtBS",
        "abstract": "Hydrophobically associating anionic terpolymer(PAtBS) was synthesized by free micellar copolymerization of acrylamide(AM),4-tert-butylstyrene(tBS) and sodium 4-vinylbenzenesulfonate(SSS).The copolymer structure was identified by FTIR,UV,and 1H-NMR.Furtherly,the aqueous solution properties of the copolymer were investigated by rotary viscometer.The results showed that the content of the monomer structural units in the copolymer coincided approximately with its feed ratio.The increasing viscosity ability of PAtBS in sodium chloride or calcium chloride aqueous solution is stronger than that of partially hydrolyzed polyacrylamide with molecular weight of 1.97\u00d7107 and hydrolysis degree of 19.43%.The viscosity of polymer aqueous solution declined slightly with the increase of temperature when the temperature was above 50\u2103,which indicated that the synthesized copolymer had good performance of salt and temperature resistance.",
        "keywords": [
            "acrylamide",
            "hydrophobically associating polymer",
            "anionic copolymer",
            "sodium 4-vinylbenzene sulfonate",
            "polymer aqueous solution",
            "4-tert-butylstyrene"
        ],
        "authors": [
            {
                "name": "LIU Lei",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Material Engineering,Sichuan University,Chengdu,Sichuan ,P R of China"
            },
            {
                "name": "JIANG Xian-Cai",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Material Engineering,Sichuan University,Chengdu,Sichuan ,P R of China"
            },
            {
                "name": "YE De-Zhan",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Material Engineering,Sichuan University,Chengdu,Sichuan ,P R of China"
            },
            {
                "name": "XIA Chao",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Material Engineering,Sichuan University,Chengdu,Sichuan ,P R of China"
            },
            {
                "name": "JIANG Ting",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Material Engineering,Sichuan University,Chengdu,Sichuan ,P R of China"
            },
            {
                "name": "DAI Hua",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Material Engineering,Sichuan University,Chengdu,Sichuan ,P R of China"
            },
            {
                "name": "ZHANG Xi",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Material Engineering,Sichuan University,Chengdu,Sichuan ,P R of China"
            }
        ],
        "venue": "Oilfield Chemistry",
        "year": 2012
    },
    "pcQm4P64": {
        "id": "pcQm4P64",
        "title": "High strength polymer/water glass gelling fluid CY-98 for selective water plugging: Structure and properties",
        "abstract": "High strength water plugging agent CY-98, a polymer (polyacrylamid)/resin and water glass mixed gelling fluid, was developed for selective water plugging in production wells at high temperature and high salinity water flooded reservoirs. The formation, constituents, and rheological behavior of gelling solution CY-98 were experimentally studied, as well as the conditions of gel formation, morphological structure, stability, and dynamic mechanical properties of the gel formed.",
        "keywords": [
            "Hostile Reservoirs",
            "Polymer/Resin/Water Glass Aqueous Gelling Fluid",
            "Polymer/Sodium Silicate Mixed Gel",
            "Water Flooded Reservoirs",
            "Water Plugging in Production Wells",
            "Water Plugging/Profile Modificating Agent"
        ],
        "authors": [
            {
                "name": "Bing Liang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Hua Dai",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xi Zhang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Ronghua Huang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Oilfield Chemistry",
        "year": 2001
    },
    "olDrQ1JL": {
        "id": "olDrQ1JL",
        "title": "STUDY ON FORMULATION AND PROPERTIES OF A NEW THICKENED ACID",
        "abstract": "Synthetic polymers are present in both gelled acid and filtration-controlled acid, bringing out the problems of difficult flowback, residual polymers kept in formations, and etc. In order to find a retarded thickened acid, a cationic surfactant with special structure and an organic metallic compound are adopted to prepare viscous HCl solution, a corrosion inhibitor with good compatibility with the acid solution is developed, and the effects of composition on properties of acid solution are investigated. The investigation results show this acid system has good properties in shear stability, corrosion inhibition, and retarded reaction. The viscosity of the system will decrease with the temperature. The viscosity of the viscous acid (4%FL4-22+2% FL4-22A+20%HCl+2% corrosion inhibitor FL4-22B) is up to 25 mPa\u00b7s at 90\u2103, the viscosity will increase then decrease when reacting with formation rocks. So the residual acid with low viscosity can be flowed back very easily. This new acid system can be applied in acidizing treatment of carbonate formations.",
        "keywords": [
            "acidizing",
            "viscosifying agent",
            "fracturing",
            "completion",
            "corrosion inhibitor",
            "frac fluid"
        ],
        "authors": [
            {
                "name": "WANG Yi",
                "org": " State Key Laboratory of Polymer Materials Engineering, Sichuan University"
            },
            {
                "name": "ZHANG Xi",
                "org": " State Key Laboratory of Polymer Materials Engineering, Sichuan University"
            },
            {
                "name": "DAI Hua",
                "org": " State Key Laboratory of Polymer Materials Engineering, Sichuan University"
            },
            {
                "name": "ZHANG Ning-kang",
                "org": " Feierte Technology Development Company, Ltd."
            },
            {
                "name": "LONG Shun-min",
                "org": " Natural Gas Institute of PetroChina Southwest Oil & Gasfield Company"
            }
        ],
        "venue": "Natural Gas Industry",
        "year": 2007
    },
    "jsehDhrj": {
        "id": "jsehDhrj",
        "title": "Study on Properties of PVA Plasticized by Caprolactam/Magnesium Chloride",
        "abstract": "Taking caprolactam/magnesium chloride as compounding plasticizer,the plasticized PVA film was prepared by casting.The effects of caprolactam/magnesium chloride compounding plasticizer on the properties of PVA were investigated by DSC,TGA,XRD,mechanical property and flow ability tests.The results show that the synergistic plasticizing effect between caprolactam and magnesium chloride is excellent,the plasticizing effect of the compounding plasticizer for PVA is better than that of pure caprolactam;the compounding plasticizer can destroy the hydrogen bonds among PVA molecules,and decreases the crystallinity of PVA;after the addition of the compounding plasticizer,the melting point and tensile strength of PVA decrease,the thermal stability,flow ability and elongation at break increase.",
        "keywords": [
            "Caprolactam",
            "Magnesium chloride",
            "Plasticization",
            "PVA"
        ],
        "authors": [
            {
                "name": "Xia Chao",
                "org": " State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute,Sichuan University,Chengdu 60065,China"
            },
            {
                "name": "Liu Lei",
                "org": " State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute,Sichuan University,Chengdu 60065,China"
            },
            {
                "name": "Jiang Xiancai",
                "org": " State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute,Sichuan University,Chengdu 60065,China"
            },
            {
                "name": "Ye Dezhan",
                "org": " State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute,Sichuan University,Chengdu 60065,China"
            },
            {
                "name": "Dai Hua",
                "org": " State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute,Sichuan University,Chengdu 60065,China"
            },
            {
                "name": "Zhang Xi",
                "org": " State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute,Sichuan University,Chengdu 60065,China"
            }
        ],
        "venue": "Plastics Science and Technology",
        "year": 2012
    },
    "ZBwAXC7q": {
        "id": "ZBwAXC7q",
        "title": "Preparation and Properties of Starch/Poly(vinyl alcohol) Film Plasticized by Magnesium Nitrate Hexahydrate",
        "abstract": "The plasticized starch/poly(vinyl alcohol)(PVA) film was prepared by casting method using magnesium nitrate hexahydrate [Mg(NO3)2\u00b76H2O] as the plasticizer.The micro morphologies of pure starch/PVA and Mg(NO3)2\u00b76H2O plasticized starch/PVA film were observed by scanning electron microscope(SEM).The interaction between Mg(NO3)2\u00b76H2O and starch/PVA molecule was investigated by Fourier transform infrared(FTIR).The crystallinity and thermal properties were measured by X-ray diffraction measurement(XRD) and thermogravimetric analysis(TGA).The mechanical properties were measured by tensile testing and dynamic mechanical analysis(DMA).It was found that Mg(NO3)2\u00b76H2O could form some interaction with starch and PVA molecules.The addition of Mg(NO3)2\u00b76H2O could improve the miscibility of starch and PVA.The XRD results showed that Mg(NO3)2\u00b76H2O could destroy the crystals of starch and PVA.The TGA results showed that the thermal stability of starch/PVA decreased with the addition of Mg(NO3)2\u00b76H2O.Tensile testing showed that Mg(NO3)2\u00b76H2O was highly effective in modifying the mechanical properties of starch/PVA film,making the elongation at break of starch/PVA film largely increased from 8% of pure starch/PVA film to 514% with 60%Mg(NO3)2\u00b76H2O.",
        "keywords": [
            "Poly(vinyl alcohol)",
            "Plasticization",
            "Magnesium nitrate hexahydrate",
            "Mechanical property",
            "Starch"
        ],
        "authors": [
            {
                "name": "JIANG Ting",
                "org": "State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University,Chengdu ,China"
            },
            {
                "name": "JIANG Xian-Cai",
                "org": "State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University,Chengdu ,China"
            },
            {
                "name": "ZHANG Xiao-Fei",
                "org": "State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University,Chengdu ,China"
            },
            {
                "name": "DAI Hua",
                "org": "State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University,Chengdu ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Chemical Journal of Chinese Universities",
        "year": 2012
    },
    "qN93Eow0": {
        "id": "qN93Eow0",
        "title": "The plasticizing mechanism and effect of calcium chloride on starch/poly(vinyl alcohol) films.",
        "abstract": "Starch/poly(vinyl alcohol) (PVA) films were prepared with calcium chloride (CaCl(2)) as the plasticizer. The micro morphology of pure starch/PVA film and CaCl(2) plasticized starch/PVA film was observed by scanning electron microscope. The interaction between CaCl(2) and starch/PVA molecules was investigated by Fourier transform infrared spectroscopy. The influence of CaCl(2) on the crystalline, thermal and mechanical properties of starch/PVA films was studied by X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, and tensile testing, respectively. The results indicated that CaCl(2) could interact with starch and PVA molecules and then effectively destroy the crystals of starch and PVA. Starch/PVA films plasticized with CaCl(2) became soft and ductile, with lower tensile strength and higher elongation at break compared with pure starch/PVA film. The water content of starch/PVA film would increase with the addition of CaCl(2). This is an important cause of the plasticization of CaCl(2) on starch/PVA film.",
        "keywords": [
            "calcium chloride",
            "starch",
            "film"
        ],
        "authors": [
            {
                "name": "Xiancai Jiang",
                "org": "State Key Laboratory of Polymer Materials Engineering, Chengdu 610065, China."
            },
            {
                "name": "Ting Jiang",
                "org": ""
            },
            {
                "name": "Lingling Gan",
                "org": ""
            },
            {
                "name": "Xiaofei Zhang",
                "org": ""
            },
            {
                "name": "Hua Dai",
                "org": ""
            },
            {
                "name": "Xi Zhang",
                "org": ""
            }
        ],
        "venue": "Carbohydrate polymers",
        "year": 2012
    },
    "CsiMWCPs": {
        "id": "CsiMWCPs",
        "title": "Preparation and properties of plasticized chitosan/starch cast films using AlCl3 6H2O aqueous solution as the solvent",
        "abstract": "In this paper, the chitosan/starch (CS/ST) cast films were prepared using AlCl3\u00b76H2O aqueous solution as the solvent for CS. AlCl3\u00b76H2O was retained in the CS/ST film acting as the plasticizer and glycerol were added to form the complex plasticizer with AlCl3\u00b76H2O. The effect of the complex plasticizer of AlCl3\u00b76H2O and glycerol on the crystalline, thermal stability, and mechanical properties of CS/ST films was studied by X-ray diffraction, thermal gravity analysis, and tensile testing, respectively. The results showed that AlCl3\u00b76H2O aqueous solution was a better solvent for CS than acetic acid aqueous solution which is the most commonly used solvent of CS. With AlCl3\u00b76H2O aqueous solution as the solvent, the thermal degradation of CS and ST in the dissolving process was weakened. Glycerol could form the synergism plasticizing effect with AlCl3\u00b76H2O. With the complex of AlCl3\u00b76H2O and glycerol as the plasticizer, the CS/ST film with the good mechanical properties could be obtained.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiancai Jiang",
                "org": "Polymer Research Institute of Sichuan University"
            },
            {
                "name": "Xiancai Jiang",
                "org": "Polymer Research Institute of Sichuan University"
            },
            {
                "name": "Xi Zhang",
                "org": "Polymer Research Institute of Sichuan University"
            }
        ],
        "venue": "Polymer Bulletin",
        "year": 2017
    },
    "WbaGV59n": {
        "id": "WbaGV59n",
        "title": "Changes in Calcium Lignosulfonate from Eucalyptus Influenced by Initiators in Graft Copolymerization",
        "abstract": "The grafting method is widely adopted for developing lignin-based polymer materials with high properties. Aimed at studying various initiators (Fenton, K2S2O8, H2O2-CaCl2) effects on calcium lignosulfonate from eucalyptus (HLS-Ca) in graft copolymerization, HLS-Ca was treated by the above initiators, respectively. Changes in the functional composition of HLS-Ca were investigated by using Difference UV, FTIR, UV spectroscopy and intrinsic viscosity ([\u03b7]) methods. The results show that the changes in the structure and reactivity of HLS-Ca were observed due to some certain reactions between it and initiators. Under our experimental conditions, the benzene ring stable against the oxidation of Fenton and K2S2O8 initiators; the content of phenolic hydroxyl (Ph-OH) group decreases under the incubation of Fenton and K2S2O8 initiators though it\u2019s not oxidized to the structure like quinone; the content of aryl-ether, [\u03b7] and viscosity-average molecular weight (W\u03b7) increase. Under the treatment of H2O2-CaCl2 initiator, the content of Ph-OH group decreases dramatically and it could be transformed to carbonyl structure. The destruction of benzene ring results in the decrease in the [\u03b7] and W\u03b7 for HLS-Ca.",
        "keywords": [
            "initiator",
            "viscosity-average molecular weight",
            "benzene ring",
            "phenolic hydroxyl group",
            "calcium lignosulfonate from eucalyptus"
        ],
        "authors": [
            {
                "name": "Gan Lingling",
                "org": "Sichuan University Chengdu "
            },
            {
                "name": "Ye Dezhan",
                "org": "Sichuan University Chengdu "
            },
            {
                "name": "Li Qiling",
                "org": "Sichuan University Chengdu "
            },
            {
                "name": "Zhang Minghua",
                "org": "Sichuan University Chengdu "
            },
            {
                "name": "Zhang Xi",
                "org": "Sichuan University Chengdu "
            }
        ],
        "venue": "Scientia Silvae Sinicae",
        "year": 2013
    },
    "U73S1zVL": {
        "id": "U73S1zVL",
        "title": "Copolymer cud for polymer drilling fluids: Synthesis, performance properties and uses",
        "abstract": "CUD, a copolymer of acrylamide with several comonomers, is a novel commercial inhibitory polymer for drilling fluids. In this paper its compatibility with various kinds of drilling fluid additives (filtrate loss controller, thinner, lubricant), heat resistance and tolerences to NaCl, CaCl2 and CaSO4 are investigated and its inhibiting capacity for shale is determined in different ways. The field uses are described briefly. The results indicate that CUD can be used for formulating free-solids, low solids and high density drilling fluids.",
        "keywords": [
            "Acrylamide Copolymer with Multiple C\ufffd\ufffdmonomers",
            "Additive for Drilling Fluids",
            "Field Uses",
            "Laboratory Evaluation of Performance Properties",
            "Shale Control Agent",
            "Viscosifier"
        ],
        "authors": [
            {
                "name": "Xi Zhang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Ronghua Huang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Hua Dai",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Ouyang",
                "org": "Sichuan Petroleum Administration(Sichuan Petroleum Administration),Chengdu,China"
            },
            {
                "name": "Yongzhong Ji",
                "org": "Sichuan Petroleum Administration(Sichuan Petroleum Administration),Chengdu,China"
            },
            {
                "name": "XiaoQing Liu",
                "org": "Sichuan Petroleum Administration(Sichuan Petroleum Administration),Chengdu,China"
            }
        ],
        "venue": "Oilfield Chemistry",
        "year": 1997
    },
    "eemhZMyw": {
        "id": "eemhZMyw",
        "title": "Properties of Poly(vinyl alcohol) Plasticized by Magnesium Chloride",
        "abstract": "The plasticized poly(vinyl alcohol)(PVA) films were prepared by the casting method using magnesium chloride(MgCl2) as the plasticizer.The interaction between MgCl2 and PVA was analysised by Fourier transform infrared(FTIR) spectroscopy.The change of the crystalline and thermal properties of PVA with the content of MgCl2 were measured by X-ray diffraction measurements(XRD),differential scanning calorimetry and thermogravimetric analysis(TGA) respectively.The mechanical properties were measured as a function of MgCl2 content.It was found that MgCl2 could form considerable interaction with PVA and form a complex.The XRD showed that the crystallinity of PVA film decreased with the content of MgCl2,which would be ascribed to the interaction of MgCl2 with PVA molecules,causing the destroying of the intra/inter molecular hydrogen bonding between PVA chains.The glass transition temperature of PVA also decreased with the content of MgCl2.The TGA results show that the thermal stabilities of PVA decreased with the addition of MgCl2 and the thermal degradation process was changed.The mechanical testing showed that PVA become soft,with lower tensile strength and higher elongation at break after modification.",
        "keywords": [
            "Poly(vinyl alcohol)",
            "Crystallinity",
            "Magnesium chloride",
            "Plasticization",
            "Thermal stability"
        ],
        "authors": [
            {
                "name": "JIANG Xian-Cai",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute of Sichuan University,Chengdu ,China"
            },
            {
                "name": "XIA Chao",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute of Sichuan University,Chengdu ,China"
            },
            {
                "name": "YE De-Zhan",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute of Sichuan University,Chengdu ,China"
            },
            {
                "name": "LIU Lei",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute of Sichuan University,Chengdu ,China"
            },
            {
                "name": "DAI Hua",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute of Sichuan University,Chengdu ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute of Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Chemical Journal of Chinese Universities",
        "year": 2012
    },
    "EJNyxhpN": {
        "id": "EJNyxhpN",
        "title": "Effect of SSMA and AMA on Reducing the Viscosity of Drilling Fluid",
        "abstract": "In order to study the relationship between the structure and properties of the copolymer thinners,SSMA and AMA thinners were synthesized using sodium p-styrene sulfonate,maleic anhydride and acrylic acid as raw materials,ammonium persulfate(APS) as initiator.The viscosity reduction performance,temperature resistance and salt tolerance of them were investigated.The results showed that SSMA and AMA,with sulfonic acid group and carboxyl group respectively,could efficiently break the links between clay particles in the drilling mud,leading to the decline of the viscosity and the shearing force.While the behaviors of SSMA and AMA became complicated at high temperature or with adding certain amount of NaCl and CaCl_2 into the drilling mud.Compared with SSMA,AMA showed the better thinning performances in both fresh-water and saline-based drilling fluid and played more effectively role in the calcium-based mud with lower dosage range(\u22640.3%),however,when the dosage was higher than 0.3%,the property of viscosity reduction of AMA became worse.The drilling fluid treated with SSMA showed the poorer resistance to NaCl pollution and stronger resistance to CaCl_2.The performance of high temperature resistance of AMA was better than that of SSMA.",
        "keywords": [
            "mud additives",
            "styrene sulfonate-maleic anhydride polymer",
            "performance evaluation",
            "acrylic-maleic anhydride polymer",
            "thinner"
        ],
        "authors": [
            {
                "name": "LI Qi-Ling",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute of Sichuan University,Chengdu,Sichuan ,P R of China"
            },
            {
                "name": "YE De-Zhan",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute of Sichuan University,Chengdu,Sichuan ,P R of China"
            },
            {
                "name": "LIU qiao",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute of Sichuan University,Chengdu,Sichuan ,P R of China"
            },
            {
                "name": "DAI Hua",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute of Sichuan University,Chengdu,Sichuan ,P R of China"
            },
            {
                "name": "ZHANG Xi",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute of Sichuan University,Chengdu,Sichuan ,P R of China"
            }
        ],
        "venue": "Oilfield Chemistry",
        "year": 2013
    },
    "B5NpGWGZ": {
        "id": "B5NpGWGZ",
        "title": "MECHANICAL PROPERTY EXPERIMENT OF THERMAL HORIZONTAL WELL EXTERNAL PACKER ELEMENT MATERIAL AT HIGH TEMPERATURE",
        "abstract": "Some oilfield using horizontal well thermal technology to produce heavy oil,it has formed certain scale at home and abroad,as compared with traditional technology,it has gotten obvious economic benefits.In recent years,after monitoring some oilfield,we have found that,only 1/3 hole section suck in steam,weakening the effect of thermal technology.In order to solve the problem that horizontal well suck in steam non-homogeneously,the segregated completion was adopted by using external packer.In thermal horizontal well,the work temperature can reach 300\u2103,but at present the polymer material can not satisfy the demand.In this thesis,an new packer element has been assessed through the experiment at high temperature(300\u2103),and its relationship of stress and strain and youngs modulus has been acquired,which provide important evidence for predicting working property of packer at high temperature.",
        "keywords": [
            "compression experiment",
            "packer",
            "thermal horizontal well",
            "high temperature",
            "material"
        ],
        "authors": [
            {
                "name": "LI Rui",
                "org": "Science and Engineering College of Sichuan University"
            },
            {
                "name": "ZHANG Xi",
                "org": "Science and Engineering College of Sichuan University"
            }
        ],
        "venue": "Drilling & Production Technology",
        "year": 2009
    },
    "DM96nvz1": {
        "id": "DM96nvz1",
        "title": "Thermosensitive P(AM-Macromer) and Complex System Property of P(AM-Macromer)/Surfacrant",
        "abstract": "The thermosensitive water-soluble polymers of acrylamide(AM) and Macromer bearing oxyethylene units have been synthesized by free radical aqueous solution copolymerization.The interactions in aqueous solution of P(AM-Macromer) and surfactants,such as SDBS,CTAB and OP-10,were studied.The results show that the interaction between P(AM-Macromer) and surfactant is obvious.The concentration of P(AM-Macromer) solution,the structure and the concentration of surfactant affact the interaction.For 0.4% polymer solution,the apparent viscosity of polymer solution increases remarkably by addition of small amount of surfactant,For 0.15% polymer solution,the addition of surfactant results in the decrease of solution viscosity.The influence sequence of surfactants is: SDBS>CTAB>OP-10.",
        "keywords": [
            "Apparent viscosity",
            "Rheology",
            "Surfactant",
            "Thermosensitive water-soluble polymer"
        ],
        "authors": [
            {
                "name": "HU Jing",
                "org": "State Key Laboratory of Polymer Materials Engineering,Chengdu ,China"
            },
            {
                "name": "ZHANG Xiao-fei",
                "org": "State Key Laboratory of Polymer Materials Engineering,Chengdu ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "State Key Laboratory of Polymer Materials Engineering,Chengdu ,China"
            },
            {
                "name": "DAI Hua",
                "org": "State Key Laboratory of Polymer Materials Engineering,Chengdu ,China"
            }
        ],
        "venue": "Polymer Materials Science & Engineering",
        "year": 2008
    },
    "ue9x749A": {
        "id": "ue9x749A",
        "title": "Study on the Properties of Associative Copolymers P(NPA-AM-NIPAM) in Aqueous Solution",
        "abstract": "The associative water-soluble copolymers P(NPA-AM-NIPAM) of N-isopropylacrylamide,acrylamide and nonylphenyl polyoxyethylene acrylate(NPA) were synthesized by free radical aqueous solution copolymerization.The copolymer structures were characterized via IR spectrum and 1H-NMR spectrum.Polymer concentration,temperature and different electrolyte on the performance of copolymer solutions were studied.The results show that different electrolyte has different effect on polymers solution.The apparent viscosity of the copolymer solution will increase with NaCl,KCl and Na2SO4 concentration rising,but the MgCl2 and CaCl2 haven't notable effect on the viscosity of P(NIPAM-AM-NPA) solution.Under the same condition,Na+ is more than K+,K+ is more than Ca+,SO2-4 is more than Cl-.The saline solution of P(NIPAM-AM-NPA) can keep high viscosity at high temperature.At properly condition,the viscosity of P(NIPAM-AM-NPA) solution increase with the temperature rising.",
        "keywords": [
            "rheology",
            "polymer solution",
            "associative water-soluble polymer",
            "N-isopropylacrylamide copolymer"
        ],
        "authors": [
            {
                "name": "PENG Da-ping",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratoryof Polymer Materials Engineering of China,Chengdu ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratoryof Polymer Materials Engineering of China,Chengdu ,China"
            },
            {
                "name": "HUANG Xiao-bing",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratoryof Polymer Materials Engineering of China,Chengdu ,China"
            },
            {
                "name": "DAI Hua",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratoryof Polymer Materials Engineering of China,Chengdu ,China"
            }
        ],
        "venue": "Polymer Materials Science & Engineering",
        "year": 2007
    },
    "ME8W7qy4": {
        "id": "ME8W7qy4",
        "title": "Preparation and Properties of PVA/Mg(NO_3)_2 Film",
        "abstract": "Poly(vinyl alcohol)(PVA)/Mg(NO3)2 blended films were prepared by casting from the solutions containing different content Mg(NO3)2 and PVA.The water content in blended films was determined at RH of 54%.The properties of PVA/Mg(NO3)2 blended films were investigated by X-ray diffraction,differential scanning calorimetry,dynamic mechanical analysis and mechanical testing.It has been shown that the addition of Mg(NO3)2 can disrupt the inter and intra chain hydrogen bonding of the PVA chains and therefore reduce the crystallinity of PVA.The water content of PVA/Mg(NO3)2 blended films increases with the amount of Mg(NO3)2.The glass transition temperature(Tg) of PVA/Mg(NO3)2 blended films is much lower than that of pure PVA films.Mechanical testing results show that PVA/Mg(NO3)2 films are of lower tensile strength and higher elongation at break compared with PVA film.",
        "keywords": [
            "Mg(NO3)2",
            "poly(vinyl alcohol)",
            "modification",
            "blended films"
        ],
        "authors": [
            {
                "name": "Xiancai Jiang",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Lei Liu",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Chao Xia",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Xi Zhang",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Hua Dai",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Polymer Materials Science & Engineering",
        "year": 2011
    },
    "Ebsgk3Fw": {
        "id": "Ebsgk3Fw",
        "title": "PREPARATION AND PERFORMANCES OF ZWITTERION POLYMER CROSS LINKED GELLED ACID",
        "abstract": "For preparing well-retarding gelling acid,the zwitterion polymer crosslinked gelling acid is formulated by zwitterion polymer containing amide groups as gelatinizer,and a mulriple system mainly composed of multi-aldehyde structure compound as crosslinker.The effect of temperature,concentration of crosslinker,polymer gelatinizer,and polymer structure on performance of crosslinked gelled acid is studied.The results show that 50%-60% content of amide groups in polymer composing crosslinked gelling acid and 1.5-2.0g/L of the crossliker are felicitous,in addition,high temperature can make for obtaining high viscidity of crosslinked gelling acid in short times.The performances of crosslinked gelling acid are systematically investigated.It is concluded that this acid system had good properties,compared with viscous acid,crosslinked acid(20%HCl+0.8wt%copolymer+1%corrosion inhibitor+2g/L cross-linker+0.25%gel-breaking agent) has high viscosity and good properties in retardance performance.The apparent viscosity and residue content of liquids after gel-breaking accord with pertinent standard.So this crosslinked gelling acid system can be applied in carbonate acidizing treatments.",
        "keywords": [
            "retarded acid",
            "gelled acid",
            "acidification",
            "zwitterion polymer",
            "acidizing fluid"
        ],
        "authors": [
            {
                "name": "LU Yang",
                "org": "State Key Laboratoryof Polymer Materials Engineering,Sichuan University"
            },
            {
                "name": "ZHANG Xi",
                "org": "State Key Laboratoryof Polymer Materials Engineering,Sichuan University"
            },
            {
                "name": "DAI Hua",
                "org": "State Key Laboratoryof Polymer Materials Engineering,Sichuan University"
            },
            {
                "name": "HUANG Li",
                "org": "CCDC Safety,Environment,Quality Supervision & Testing Research Institute"
            }
        ],
        "venue": "Drilling & Production Technology",
        "year": 2009
    },
    "CYhh44FG": {
        "id": "CYhh44FG",
        "title": "Research Progress in the Modification of Lignin from Pulping Waste Liquor Used as Sand-fixing Agent",
        "abstract": "Lignin from pulping waste liquor has attracted more and more attention recently because of its abundance and low cost.It can be modified and used as sand-fixing agent to improve some properties of sand or soil,such as the compressive strength,the ability of resistant to wind erosion,aggregate content.In this paper,the characteristic chemical structures of lignin,structure and sand-fixing efficiency of several modified lignin sand-fixing agent were reviewed.Finally,some modified methods were suggested and these suggestions would be useful for developing effective lignin sand-fixing agent and fully utilizing the lignin from pulping waste liquor.",
        "keywords": [
            "modified method",
            "lignin",
            "sand-fixing agent",
            "chemical structure",
            "pulping waste liquor"
        ],
        "authors": [
            {
                "name": "YE De-zhan",
                "org": "Polymer Research Institute of Sichuan University,State Key Lab of Polymer Material Engineering, Chengdu,Sichuan Province,"
            },
            {
                "name": "JIANG Xian-cai",
                "org": "Polymer Research Institute of Sichuan University,State Key Lab of Polymer Material Engineering, Chengdu,Sichuan Province,"
            },
            {
                "name": "XIA Chao",
                "org": "Polymer Research Institute of Sichuan University,State Key Lab of Polymer Material Engineering, Chengdu,Sichuan Province,"
            },
            {
                "name": "LIU Lei",
                "org": "Polymer Research Institute of Sichuan University,State Key Lab of Polymer Material Engineering, Chengdu,Sichuan Province,"
            },
            {
                "name": "DAI Hua",
                "org": "Polymer Research Institute of Sichuan University,State Key Lab of Polymer Material Engineering, Chengdu,Sichuan Province,"
            },
            {
                "name": "ZHANG Xi",
                "org": "Polymer Research Institute of Sichuan University,State Key Lab of Polymer Material Engineering, Chengdu,Sichuan Province,"
            }
        ],
        "venue": "Transactions of China Pulp and Paper",
        "year": 2011
    },
    "yQdzy2le": {
        "id": "yQdzy2le",
        "title": "Lignosulfonate as reinforcement in polyvinyl alcohol film: Mechanical properties and interaction analysis.",
        "abstract": "Recently, there has been a growing research interest on renewable composite due to sustainability concerns. This work demonstrated the possibility of using eucalyptus lignosulfonate calcium &lpar;HLS&rpar; particles as reinforcement in polyvinyl alcohol &lpar;PVA&rpar; matrix. 41% and 384.7% improvement of pure PVA tensile strength and Young's modulus were achieved with incorporation of 5wt% HLS. The above results were ascribed to specific intermolecular interactions between HLS and PVA, suggested by the increasing PVA glass transition and crystalline relaxations temperature, depression of melting point with HLS incorporation. Moreover, this interaction was quantitatively determined by q value of -62.4\u00b110.0 in Kwei equation. Additionally, the remarkable red shift of wavenumber corresponding to hydroxyl group also indicated the formation of strong hydrogen bond in HLS/PVA blend. SEM characterization confirmed that HLS/PVA blends are at least miscible.",
        "keywords": [
            "lignosulfonate",
            "polyvinyl alcohol",
            "reinforcement"
        ],
        "authors": [
            {
                "name": "De-zhan Ye",
                "org": "Polymer Research Institute, Sichuan University, Chengdu 610065, PR China; State Key Laboratory of Polymer Material Engineering, Sichuan University, Chengdu 610065, PR China."
            },
            {
                "name": "Li Jiang",
                "org": "Polymer Research Institute, Sichuan University, Chengdu 610065, PR China; State Key Laboratory of Polymer Material Engineering, Sichuan University, Chengdu 610065, PR China."
            },
            {
                "name": "Xiao-qin Hu",
                "org": "Polymer Research Institute, Sichuan University, Chengdu 610065, PR China; State Key Laboratory of Polymer Material Engineering, Sichuan University, Chengdu 610065, PR China."
            },
            {
                "name": "Ming-hua Zhang",
                "org": "Polymer Research Institute, Sichuan University, Chengdu 610065, PR China; State Key Laboratory of Polymer Material Engineering, Sichuan University, Chengdu 610065, PR China."
            },
            {
                "name": "Xi Zhang",
                "org": "Polymer Research Institute, Sichuan University, Chengdu 610065, PR China; State Key Laboratory of Polymer Material Engineering, Sichuan University, Chengdu 610065, PR China."
            }
        ],
        "venue": "International journal of biological macromolecules",
        "year": 2015
    },
    "BuDSOcLp": {
        "id": "BuDSOcLp",
        "title": "Study on Properties of PVA Plasticized Urea/Formamide",
        "abstract": "The modified PVA films were prepared by casting method using urea/formamide as a mixed plasticizer.The interaction between urea/formamide and PVA was investigated by FTIR.The properties of urea/formamide plasticized PVA films were studied by XRD,DSC,TGA and tensile property testing.The results showed that the hydrogen bonding in PVA films was formed by the addition of urea/formamide.The crystalline of PVA was destroyed and the degree of crystallinity was reduced.The melting points of PVA films were reduced and the thermal decomposition temperature of PVA films was enhanced with the addition of urea/formamide.PVA films lowered the tensile strength.The elongation at break was increased.",
        "keywords": [
            "Thermal Stability",
            "Plasticizer",
            "Urea",
            "PVA",
            "Modification"
        ],
        "authors": [
            {
                "name": "LI Qi-ling",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute, Sichuan University,Chengdu ,China"
            },
            {
                "name": "JIANG Xian-cai",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute, Sichuan University,Chengdu ,China"
            },
            {
                "name": "DAI Hua",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute, Sichuan University,Chengdu ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "State Key Laboratory of Polymer Materials Engineering,Polymer Research Institute, Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "China Plastics Industry",
        "year": 2012
    },
    "se5kZyvW": {
        "id": "se5kZyvW",
        "title": "The graft polymers from different species of lignin and acrylic acid: synthesis and mechanism study.",
        "abstract": "The influence of lignin species on the grafting mechanism of lignosulfonate (from eucalyptus and pine, recorded as HLS and SLS, respectively) with acrylic acid (AA) was investigated. The graft polymers were confirmed by the absorption of carbonyl groups in the FTIR spectra. The decreasing phenolic group's content (Ph-OH) is not only due to its participation as grafting site but also to the negative effect of initiator. In the initial period (0-60 min), HLS and SLS both accelerate the polymerization of AA. Additionally, Ph-OH group's content is proportional to product yield (Y%), monomer conversion (C%) and grafting efficiency (GE%), strongly indicating that it acts as active center. Nevertheless, compared with HLS, Y% and C% in SLS grafting system are lower though it has higher Ph-OH group's content, which is due to the quinonoid structure formed by the self-conjugated of phenoxy radical in Guaiacyl unit. Finally, the lignosulfonate grafting mechanism was proposed.",
        "keywords": [
            "aa",
            "acrylic acid",
            "c%",
            "duv",
            "difference ultraviolet spectroscopy",
            "ftir",
            "fourier transform infrared",
            "ge%",
            "grafting mechanism",
            "h(2)o(2)",
            "hls",
            "hls graft polymer",
            "hls-aa",
            "k(2)s(2)o(8)",
            "lignin species",
            "ph-oh",
            "phenolic group",
            "sls",
            "sls graft polymer",
            "sls-aa",
            "thls",
            "thls1",
            "tsls",
            "tsls1",
            "y%",
            "eucalyptus lignosulfonate calcium",
            "grafting efficiency",
            "hydrogen peroxide",
            "monomer conversion",
            "pine lignosulfonate sodium",
            "potassium persulfate",
            "product yield",
            "treated hls by h(2)o(2)",
            "treated hls by k(2)s(2)o(8)",
            "treated sls by h(2)o(2)",
            "treated sls by k(2)s(2)o(8)"
        ],
        "authors": [
            {
                "name": "De zhan Ye",
                "org": "Polymer Research Institute, Sichuan University, Chengdu 610065, PR China; State Key Laboratory of Polymer Material Engineering, Sichuan University, Chengdu 610065, PR China."
            },
            {
                "name": "Li Jiang",
                "org": "Polymer Research Institute, Sichuan University, Chengdu 610065, PR China; State Key Laboratory of Polymer Material Engineering, Sichuan University, Chengdu 610065, PR China."
            },
            {
                "name": "Chao Ma",
                "org": "Polymer Research Institute, Sichuan University, Chengdu 610065, PR China; State Key Laboratory of Polymer Material Engineering, Sichuan University, Chengdu 610065, PR China; Petroleum Engineering College of Yangtze University, Wuhan 430100, PR China."
            },
            {
                "name": "Ming-hua Zhang",
                "org": "Polymer Research Institute, Sichuan University, Chengdu 610065, PR China; State Key Laboratory of Polymer Material Engineering, Sichuan University, Chengdu 610065, PR China."
            },
            {
                "name": "Xi Zhang",
                "org": "Polymer Research Institute, Sichuan University, Chengdu 610065, PR China; State Key Laboratory of Polymer Material Engineering, Sichuan University, Chengdu 610065, PR China."
            }
        ],
        "venue": "International journal of biological macromolecules",
        "year": 2014
    },
    "LVOi9AXy": {
        "id": "LVOi9AXy",
        "title": "Synthesis of hydrophobically associating acrylamide-modified terpolymer",
        "abstract": "The hydrophobically associating water-soluble acrylamide-modified copolymers (PASA) with butyl styrene (BS) and sodium-2-acrylamido-2-methylpropane sulphonate (NaAMPS) were synthesized by the micellar free radical copolymerization technique. The two key problems including the very poor water-solubility and thermal stability of the hydrophobically associating water-soluble polymers are overcome in this study, which are due to the incorporation of the anionic monomer NaAMPS into the PASA molecules and the phenyl group from BS which can stabilize the hydrophobic units. The influence of reaction conditions on the apparent viscosity of PASA aqueous solution was studied, and the suitable reaction parameters including mole percentage of NaAMPS, mole percentage of BS, mole percentage of initiator, relative to total monomers, mass percentage of total monomers in water, mass percentage of surfactant in water, reaction temperature, pH value and reaction time were 10%, 2.5%, 0.07%, 10%, 6.0%, 50\u00b0C, pH 6-7 and 12 h, respectively. Under the above reaction conditions, the polymer was synthesized, which critical association mass concentration was about 0.05 g\u00b7dl -1. The apparent viscosities of 0.05 g\u00b7dl -1 and 0.1 g\u00b7dl -1 PASA aqueous solution were 283 mPa\u00b7s and 1020 mPa\u00b7s, respectively. The synthesized product was characterized with UV, FT-IR, 1H-NMR and elemental analysis. The block-structure of the polymer was shown by DSC measurement, which was favourable to the intermolecular hydrophobic association.",
        "keywords": [
            "Acrylamide",
            "Butyl styrene",
            "Hydrophobically associating",
            "Micellar free radical copolymerization",
            "Structure characterization"
        ],
        "authors": [
            {
                "name": "Chuanrong Zhong",
                "org": "Chengdu University of Technology(Chengdu University of Technology),Chengdu,China"
            },
            {
                "name": "Ronghua Huang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xi Zhang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Hua Dai",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Huagong Xuebao/Journal of Chemical Industry and Engineering (China)",
        "year": 2006
    },
    "pZagcRw1": {
        "id": "pZagcRw1",
        "title": "Synthesis and Solution Properties of Acrylamide-4-vinylbenzenesulfonate-n-butyl Styrene Tercopolymer PAnBS",
        "abstract": "A hydrophobically associating anionic terpolymer PAnBS was prepared by free-radical micelle copolymerization of acrylamide,sodium 4-vinylbenzenesulfonate(SSS) and n-butyl styrene(nBS).PAnBS offers a solution to the the problem of poor thermal stability of the hydrophobically associating water-soluble polymers.The structure of the synthesized polymer was characterized by means of UV,FTIR,and 1HNMR.The influence of polymerization reaction conditions on the apparent viscosity of the polymerization product aqueous solution was studied.The optimum reaction conditions were determined as follows:mole percentage of nBS,SSS and initiator were 1.5%,9% and 0.1% relative to total monomers,mass percentage of total monomers and surfactant(SDS) were 25% and 6%,and the reaction temperature and reaction time were 50 \u2103 and 10 h respectively.The viscosity-increasing ability of PAnBS prepared under the above reaction conditions in sodium chloride or calcium chloride aqueous solution is stronger than that of partially hydrolyzed polyacrylamide with molecular weight of 1.97 \u00d7 107 and hydrolysis degree of 19.43%.The viscosity of polymer aqueous solution declined slightly with the increase of temperature,which indicate that the synthesized copolymer had good performance of salt and temperature resistance.",
        "keywords": [
            "micellar free radical copolymerization",
            "acrylamide",
            "n-butyl styrene",
            "hydrophobically associating polymer",
            "oil-field chemicals and petroleum additives",
            "anionic copolymer",
            "4-vinylbenzenesulfonate",
            "polymer aqueous solution"
        ],
        "authors": [
            {
                "name": "LIU Qiao",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Material Engineering,Sichuan University,Chengdu ,Sichuan,China"
            },
            {
                "name": "LIU Lei",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Material Engineering,Sichuan University,Chengdu ,Sichuan,China"
            },
            {
                "name": "XU Bin",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Material Engineering,Sichuan University,Chengdu ,Sichuan,China"
            },
            {
                "name": "MA Chao",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Material Engineering,Sichuan University,Chengdu ,Sichuan,China"
            },
            {
                "name": "LI Qi-ling",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Material Engineering,Sichuan University,Chengdu ,Sichuan,China"
            },
            {
                "name": "DAI Hua",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Material Engineering,Sichuan University,Chengdu ,Sichuan,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Material Engineering,Sichuan University,Chengdu ,Sichuan,China"
            }
        ],
        "venue": "Fine Chemicals",
        "year": 2013
    },
    "ugtUUKJa": {
        "id": "ugtUUKJa",
        "title": "Properties of Thermo-Sensitive Polymer/PVA Complex Solution",
        "abstract": "PVA with different alcoholysis degree has been prepared.The P(AM-Macromer) was synthesized using Macromer(a thermo-sensitive monomer)and acrylamide.The properties of PVA,P(AM-Macromer),and complex solution were tested.The result shows that the P(AM-Macromer) aqueous solution has a character of thermo-sensitive.The law of apparent viscosity with the temperature increasing for PVA solution is concerned with PVA's alcoholysis degree,The complex effect of PVA and P(AM-Macromer) in aqueous solution is evident.The complex solution has the character of thermo-sensitive and Salt-sensitive even for the PVA with high alcoholysis degree.The elasticity of the complex solution is intensified as temperature increasing.The thermo-sensitive temperature for complex solution of P(AM-Macromer) and PVA(alcoholysis degree is 80% and polymerization is 2400),is lower than that for P(AM-Macromer) aqueous solution.",
        "keywords": [
            "Complex solution",
            "Polymer aqueous solution",
            "Polyvinyl alcohol",
            "Rheology",
            "Thermo-sensitive polymer"
        ],
        "authors": [
            {
                "name": "ZHU Li",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Materials Engineering,Chengdu ,China"
            },
            {
                "name": "LI Yu",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Materials Engineering,Chengdu ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Materials Engineering,Chengdu ,China"
            },
            {
                "name": "Xiaofei Zhang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "DAI Hua",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Materials Engineering,Chengdu ,China"
            }
        ],
        "venue": "Polymer Materials Science & Engineering",
        "year": 2008
    },
    "rwfAsGHj": {
        "id": "rwfAsGHj",
        "title": "Study on formulation and properties of a new thickened acid",
        "abstract": "Synthetic polymers are present in both gelled acid and filtration-controlled acid, bringing out the problems of difficult flowback, residual polymers kept in formations, etc. To find a retarded thickened acid, a cationic surfactant with special structure and an organic metallic compound are adopted to prepare viscous HCl solution, a corrosion inhibitor with good compatibility with the acid solution is developed, and the effects of composition on properties of acid solution are studied. This acid system has good properties in shear stability, corrosion inhibition, and retarded reaction. The viscosity of the system decrease with the temperature. The viscosity of the viscous acid (4%FL4-22+2% FL4-22A+20%HCl+2% corrosion inhibitor FL4-22B) is up to 25 mPa/sec at 90\u00b0C, the viscosity increase then decrease when reacting with formation rocks. The residual acid with low viscosity can be flowed back very easily. This new acid system can be applied in acidizing treatment of carbonate formations.",
        "keywords": [
            "Acidizing",
            "Completion",
            "Corrosion inhibitor",
            "Frac fluid",
            "Fracturing",
            "Viscosifying agent"
        ],
        "authors": [
            {
                "name": "Yi Wang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xi Zhang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Hua Dai",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Ning kang Zhang",
                "org": "Feierte Technology Development Company, Ltd(Feierte Technology Development Company, Ltd),,"
            },
            {
                "name": "Shun M. Long",
                "org": "PetroChina Southwest Oil and Gasfield Company(PetroChina Southwest Oil and Gasfield Company,PetroChina Southwest Oil and Gas Field Company,Southwest Oil and Gas Field Company),,China"
            }
        ],
        "venue": "Natural Gas Industry",
        "year": 2007
    },
    "pQ0jaOsy": {
        "id": "pQ0jaOsy",
        "title": "SYNTHESIS AND PROPERTIES OF POROUS ACRYLATE RESIN",
        "abstract": "The oil absorption resins were synthesized by suspension polymerization,using butyl methacrylate (BMA) and methyl methacrylate(MMA) as monomers,divinylbenzene(DVB) as crosslinker, benzoyl peroxide(BPO) as initiator,and chloroform(CHCl_3) as pore making agent.The effects of crosslinker,initiator,pore making agent and mass ratio of monomers on the structure and performance of the prepared resin were investigated.The swelling kinetics of the resin in CHCl_3 was studied. The results showed that pore making agent(CHCl_3) can increase the porosity of the resin.The most effective synthetic conditions for the resin with the highest oil absorption capacity were:m(MMA): m(BMA)=1:1,w(DVB)=0.5%,w(BPO)=1.0%,w(CHCl_3)=50%.The absorption capacity of the resin in CHCl_3 was 13.9 g/g.The pervasion of CHCl_3 into the oil absorption resin was Non-Fickian diffusion,and the swelling dynamic equation of the oil absorption resin could be expressed as (W_t=1)/13.5=0.081 8t~(0.924).",
        "keywords": [
            "trichloromethane",
            "oil absoption resin",
            "acrylate",
            "swelling kinetic",
            "synthesis",
            "suspension polymerization"
        ],
        "authors": [
            {
                "name": "Dong Haiya",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Materials Engineering,Chengdu ,Sichuan,China"
            },
            {
                "name": "Zhang Xi",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Materials Engineering,Chengdu ,Sichuan,China"
            },
            {
                "name": "Dai Hua",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Materials Engineering,Chengdu ,Sichuan,China"
            },
            {
                "name": "Xie Jingsi",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Materials Engineering,Chengdu ,Sichuan,China"
            },
            {
                "name": "Jiang Xiancai",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Materials Engineering,Chengdu ,Sichuan,China"
            }
        ],
        "venue": "Speciality Petrochemicals",
        "year": 2009
    },
    "qws5CmGp": {
        "id": "qws5CmGp",
        "title": "Synthesis and Properties of PVA/P(AA-AM) Composite Hydrogel",
        "abstract": "P(AA-AM) copolymer based on acryl acid(AA) and acrylamide(AM) was synthesized by water solution polymerization with potassium peroxydisulfate and natrium sulfurosum as initiator,The PVA/P(AA-AM) composite hydrogel was prepared from aqueous solution containing PVA and P(AA-AM) by using glutaraldehyde as the crosslinker,the property and microcosmic structure of PVA/P(AA-AM) composite hydrogel was studied,The effects of crosslinker amount,P(AA-AM) content in PVA/P(AA-AM) hydrogels and pH on swelling ration were studied.The results show that the swelling ratio of hydrogels has the relationship with the crosslinker amount: the swelling ratio increases to the largest at 0.5% glutaraldehyde and then reduces with the crosslinker amount increasing.P(AA-AM) amount in PVA/ P(AA-AM) hydrogels has significant effect on the swelling ratio and pH sensitivity of hydrogels.The pH sensitivity of PVA/P(AA-AM) hydrogels increases with P(AA-AM) amount in the hydrogel.",
        "keywords": [
            "swelling ratio",
            "pH sensitivity",
            "P(AA-AM)",
            "PVA/P(AA-AM) hydrogels"
        ],
        "authors": [
            {
                "name": "HUANG Xiao-bing",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Materials Engineering,Chengdu ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Materials Engineering,Chengdu ,China"
            },
            {
                "name": "DAI Hua",
                "org": "Polymer Research Institute of Sichuan University,State Key Laboratory of Polymer Materials Engineering,Chengdu ,China"
            }
        ],
        "venue": "Polymer Materials Science & Engineering",
        "year": 2008
    },
    "j3V2BaVi": {
        "id": "j3V2BaVi",
        "title": "Separation and Characterization of Graft Copolymer from Eucalyptus Calcium Lignosulfonate and Acrylic Acid",
        "abstract": "Graft copolymerization of eucalyptus calcium lignosulfonate(HLS-Ca) with acrylic acid(AA) was carried out using Fenton regent as a redox initiator.The separation efficiently of traditional precipitation-soxhlet extraction method was investigated,and a new centrifugal separation-combined with soxhlet extraction method was proposed.The chemical structures of HLS-Ca and the graft polymer(HLS-AA) were characterized by FT-IR,UV and 1H-NMR.The results showed that compared with traditional method,the new separation method is more effective to separate the graft polymer from homopolymer and unreacted HLS-Ca.The band at 1727 cm-1 in FT-IR spectrum is assigned to carbonyl absorption;the stronger absorbed band at 210 nm in the UV spectrum can be observed in HLS-AA and the signals between 10 and 14,assigned to the absorption for carboxyl hydrogen,also can be observed in the 1H-NMR spectrum of HLS-AA.",
        "keywords": [
            "acrylic acid",
            "separation method",
            "eucalyptus calcium lignosulfonate",
            "graft copolymer",
            "structure characterizations"
        ],
        "authors": [
            {
                "name": "YE De-zhan",
                "org": "Polymer Research Institute of Sichuan University,State Key Lab of Polymer Material Engineering, Sichuan University,Chengdu,Sichuan Province,"
            },
            {
                "name": "LIU Lei",
                "org": "Polymer Research Institute of Sichuan University,State Key Lab of Polymer Material Engineering, Sichuan University,Chengdu,Sichuan Province,"
            },
            {
                "name": "XIA Chao",
                "org": "Polymer Research Institute of Sichuan University,State Key Lab of Polymer Material Engineering, Sichuan University,Chengdu,Sichuan Province,"
            },
            {
                "name": "DAI Hua",
                "org": "Polymer Research Institute of Sichuan University,State Key Lab of Polymer Material Engineering, Sichuan University,Chengdu,Sichuan Province,"
            },
            {
                "name": "ZHANG Xi",
                "org": "Polymer Research Institute of Sichuan University,State Key Lab of Polymer Material Engineering, Sichuan University,Chengdu,Sichuan Province,"
            }
        ],
        "venue": "Transactions of China Pulp and Paper",
        "year": 2013
    },
    "8cvwlb1o": {
        "id": "8cvwlb1o",
        "title": "Preparation and Properties of Water-swellable Butadiene-acrylonitrile Rubber Modified by P(AM-g-NBR)",
        "abstract": "The water-swellable butadiene-acrylonitrile rubber(WAR-NB) was prepared by blending butadiene-acrylonitriel rubber(NBR) with super absorbent resin(SAR-PA),and using acrylamide grafted butadiene-acrylonitrile rubber P(AM-g-NBR) as compatibilizer.The effects of the P(AM-g-NBR) and SAR-PA on the properties of the water-swallable butadiene-acrylonitrile rubber were investigated.The results showed that P(AM-g-NBR) can improve the tensile strength and swelling ratio of WSR-NB.The volume expansibility of the WSR-NB increased with the increase of the amount of the SAR-PA,but its physical properties decreased.",
        "keywords": [
            "water-swellable rubber",
            "acrylamide grafted butadiene-acrylonitrile rubber",
            "butadiene-acrylonitrile rubber",
            "blending"
        ],
        "authors": [
            {
                "name": "XIE Jing-si",
                "org": "State Key Laboratory of Polymer Materials Engineering,Sichuan University,Sichuan Chengdu ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "State Key Laboratory of Polymer Materials Engineering,Sichuan University,Sichuan Chengdu ,China"
            },
            {
                "name": "DAI Hua",
                "org": "State Key Laboratory of Polymer Materials Engineering,Sichuan University,Sichuan Chengdu ,China"
            },
            {
                "name": "DONG Hai-ya",
                "org": "State Key Laboratory of Polymer Materials Engineering,Sichuan University,Sichuan Chengdu ,China"
            },
            {
                "name": "JIANG Xian-cai",
                "org": "State Key Laboratory of Polymer Materials Engineering,Sichuan University,Sichuan Chengdu ,China"
            }
        ],
        "venue": "Guangzhou Chemical Industry",
        "year": 2010
    },
    "1FPhblXk": {
        "id": "1FPhblXk",
        "title": "Fluid\u2010driven nucleation and propagation of splay fractures from a permeable fault",
        "abstract": "Progressive development of opening-mode splay or branch fractures along a permeable fault in an elastic medium, subject to elevated fluid pressure from a constant influx fluid source, is studied numerically using a plane-strain hydraulic fracturing model that couples fracture deformation and fluid flow. In situ stresses are imposed so that their resultant shear stress on the fault is lower than the frictional strength. New splay fractures are initiated based on satisfying a dual criterion for both tensile strength and fracture toughness and meeting a minimum fracture spacing requirement. Numerical results demonstrate that spatial variations in permeability along faults can cause arrest of local slip and the created slip gradient can result in splay fracture initiation at a significant distance inward from the fault tips. One splay fracture generally grows first, and the kinematic coherence in displacements at the junction between it and the fault can reduce the downstream flow rate to prevent the nucleation of other splay fractures. However, the number of splay fractures can be increased when the branch growth extent is limited to a certain size; when the fault is divided into many segments, each with a linear distributed initial aperture; and if the main fault is curved. The generation of a number of splay fractures can act to increase the permeability of the rock mass. When the splay fractures are constrained by two faults, a rhomb-shaped fault zone involving multiple high-angle branches forms. The development of the second-generation splay fractures on a first-generation one is promoted by fluid penetration. Multiple fluid-driven splay fractures can be created under the condition that fluid pressure is below or slightly above the fault confining stress. This implies that generation of complex splay fracture patterns requires less energy than generating a single opening-mode fracture. Multiple fluid-driven splay fracture nucleation and growth into a horsetail pattern occur when the fault-parallel in situ normal stress becomes more tensile. In addition, the effects of fluid viscosity and tensile fracture toughness are investigated to determine their role in splay fracture initiation and growth.",
        "keywords": "",
        "authors": [
            {
                "name": "Xi Zhang",
                "org": "CSIRO Energy Melbourne Australia"
            },
            {
                "name": "Robert G. Jeffrey",
                "org": "CSIRO Energy Melbourne Australia"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2016
    },
    "MfMX7SSX": {
        "id": "MfMX7SSX",
        "title": "Predictions of fracture growth in Walloon coals using a layer fracture model",
        "abstract": "Individual low-permeability Walloon coal seams are separated by the stiffer beds of carbonaceous shales, mudstone, siltstone and sandstone in the Surat basin. Considering the thin nature of Walloon coals, the fracture growth across the stiffer beds becomes a key issue in assessing the fracture treatment efficiency and in determining the impacts of fracture stimulation on groundwater resources. A hydraulic fracture model considering the elastic property difference across layers is developed to obtain the fracture growth behaviours in a multiple layer formation. A case study was performed where the in situ stress across beds is of similar magnitudes to highlight the effect of property difference. The fracture initiates at the targeted lower coal seam and the complex footprints generated by fracture growth are obtained. In contrast to the assumed constant fracture height and the large fracture height to length ratio obtained by other layer models, the vertical fracture growth is limited in the propagation speed by the alternating stiff and compliant rocks. The alternating growth in lateral and vertical directions results in an oscillating pressure, which is an indicative for fracture height growth.",
        "keywords": "",
        "authors": [
            {
                "name": "Xi Zhang",
                "org": "CSIRO Energy, Melbourne, Vic. 3168, Australia."
            },
            {
                "name": "Bisheng Wu",
                "org": "CSIRO Energy, Melbourne, Vic. 3168, Australia."
            },
            {
                "name": "Luke D. Connell",
                "org": "CSIRO Energy, Melbourne, Vic. 3168, Australia."
            },
            {
                "name": "Yanhui Han",
                "org": "Aramco Services Company: Aramco Research Center, Houston, TX 77084, USA."
            }
        ],
        "venue": "The APPEA Journal",
        "year": 2018
    },
    "GqFOiOvy": {
        "id": "GqFOiOvy",
        "title": "An approximate solution for predicting the heat extraction and preventing heat loss from a closed-loop geothermal reservoir",
        "abstract": "Approximate solutions are found for a mathematical model developed to predict the heat extraction from a closed-loop geothermal system which consists of two vertical wells (one for injection and the other for production) and one horizontal well which connects the two vertical wells. Based on the feature of slow heat conduction in rock formation, the fluid flow in the well is divided into three stages, that is, in the injection, horizontal, and production wells. The output temperature of each stage is regarded as the input of the next stage. The results from the present model are compared with those obtained from numerical simulator TOUGH2 and show first-order agreement with a temperature difference less than 4\u00b0C for the case where the fluid circulated for 2.74 years. In the end, a parametric study shows that () the injection rate plays dominant role in affecting the output performance, () higher injection temperature produces larger output temperature but decreases the total heat extracted given a specific time, () the output performance of geothermal reservoir is insensitive to fluid viscosity, and () there exists a critical point that indicates if the fluid releases heat into or absorbs heat from the surrounding formation.",
        "keywords": "",
        "authors": [
            {
                "name": "Bisheng Wu",
                "org": ""
            },
            {
                "name": "Tianshou Ma",
                "org": ""
            },
            {
                "name": "Guanhong Feng",
                "org": ""
            },
            {
                "name": "Zuorong Chen",
                "org": ""
            },
            {
                "name": "Xi Zhang",
                "org": ""
            }
        ],
        "venue": "Geofluids",
        "year": 2017
    },
    "N1WLfCOz": {
        "id": "N1WLfCOz",
        "title": "Multi-Scale Energy Release Rate in Dynamic Crack Growth of Strain-Softening Materials",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xi zhang",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "yiuwing mai",
                "org": "city university of hong kong"
            }
        ],
        "venue": "",
        "year": 2002
    },
    "COxNlJ9o": {
        "id": "COxNlJ9o",
        "title": "Measurement and Analysis of Full-Scale Hydraulic Fracture Initiation and Reorientation",
        "abstract": "Hydraulic fracture breakdown and reorientation data collected from two instrumented test borehole sites have been analyzed to assess the effect of the initiation type (axial or transverse) on the treating pressure. Vertical boreholes were drilled and fractures were placed in a conglomerate at depths of 140\u2013180 m in a far-field stress field that favored horizontal fracture growth. Axial initiation resulted in high injection pressure, which was attributed to near-borehole tortuosity generated as the hydraulic fracture reoriented to align with the far-field stresses. Acoustic scanner logging of the boreholes after fracturing demonstrated that, in many cases, axial initiation occurred and when this was the case, treating pressures were high and consistent with near-borehole tortuous fracture paths. A fracture initiation analysis determined that initiation at abrasively cut circumferential slots should occur before axial initiation. Slots were cut to locate the initiation sites and to make transverse fracture initiation more likely. Transverse initiation from the vertical boreholes at pre-cut slots lowered the injection pressures during the fracture treatment by up to 12 MPa for water injected at approximately 500 L per minute.",
        "keywords": [
            "Hydraulic fracturing",
            " Initiation",
            " Transverse",
            " Axial",
            " Tortuous",
            " Slots"
        ],
        "authors": [
            {
                "name": "robert g jeffrey",
                "org": "SCT Operations Pty. Ltd.,Wollongong,Australia"
            },
            {
                "name": "z r chen",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "xiaoqing zhang",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "andrew p bunger",
                "org": "university of pittsburgh"
            },
            {
                "name": "k w mills",
                "org": "SCT Operations Pty. Ltd.,Wollongong,Australia"
            }
        ],
        "venue": "Rock Mechanics and Rock Engineering",
        "year": 2015
    },
    "fK4t2Ie5": {
        "id": "fK4t2Ie5",
        "title": "Deep geothermal: The \u2018Moon Landing\u2019 mission in the unconventional energy and minerals space",
        "abstract": "Deep geothermal from the hot crystalline basement has remained an unsolved frontier for the geothermal industry for the past 30 years. This poses the challenge for developing a new unconventional geomechanics approach to stimulate such reservoirs. While a number of new unconventional brittle techniques are still available to improve stimulation on short time scales, the astonishing richness of failure modes of longer time scales in hot rocks has so far been overlooked. These failure modes represent a series of microscopic processes: brittle microfracturing prevails at low temperatures and fairly high deviatoric stresses, while upon increasing temperature and decreasing applied stress or longer time scales, the failure modes switch to transgranular and intergranular creep fractures. Accordingly, fluids play an active role and create their own pathways through facilitating shear localization by a process of time-dependent dissolution and precipitation creep, rather than being a passive constituent by simply following brittle fractures that are generated inside a shear zone caused by other localization mechanisms. We lay out a new theoretical approach for the design of new strategies to utilize, enhance and maintain the natural permeability in the deeper and hotter domain of geothermal reservoirs. The advantage of the approach is that, rather than engineering an entirely new EGS reservoir, we acknowledge a suite of creep-assisted geological processes that are driven by the current tectonic stress field. Such processes are particularly supported by higher temperatures potentially allowing in the future to target commercially viable combinations of temperatures and flow rates.",
        "keywords": [
            "geothermal energy",
            " enhanced geothermal systems",
            " fracture mechanics",
            " creep",
            " dissolution",
            " precipitation"
        ],
        "authors": [
            {
                "name": "klaus regenauerlieb",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "andrew p bunger",
                "org": "university of pittsburgh"
            },
            {
                "name": "hui tong chua",
                "org": "university of new south wales"
            },
            {
                "name": "a v dyskin",
                "org": "university of new south wales"
            },
            {
                "name": "florian fusseis",
                "org": "university of edinburgh"
            },
            {
                "name": "oliver gaede",
                "org": "queensland university of technology"
            },
            {
                "name": "robert g jeffrey",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "ali karrech",
                "org": "university of new south wales"
            },
            {
                "name": "thomas kohl",
                "org": "karlsruhe institute of technology"
            },
            {
                "name": "jie liu",
                "org": "sun yat sen university"
            },
            {
                "name": "vladimir lyakhovsky",
                "org": "Geological Survey of Israel,Jerusalem,Israel"
            },
            {
                "name": "elena pasternak",
                "org": "university of new south wales"
            },
            {
                "name": "robert podgorney",
                "org": "Idaho National Laboratory,Idaho Falls,USA"
            },
            {
                "name": "thomas poulet",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "sheik rahman",
                "org": "university of western australia"
            },
            {
                "name": "christoph schrank",
                "org": "queensland university of technology"
            },
            {
                "name": "m g trefry",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "manolis veveakis",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "bisheng wu",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "david a yuen",
                "org": "china university of geosciences"
            },
            {
                "name": "florian wellmann",
                "org": "rwth aachen university"
            },
            {
                "name": "xi zhang",
                "org": "commonwealth scientific and industrial research organisation"
            }
        ],
        "venue": "Journal of Earth Science",
        "year": 2015
    },
    "FK6sMZj5": {
        "id": "FK6sMZj5",
        "title": "Fluid-driven multiple fracture growth from a permeable bedding plane intersected by an ascending hydraulic fracture: MULTIPLE HYDRAULIC FRACTURE GROWTH",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Xi Zhang",
                "org": ""
            },
            {
                "name": "Robert G. Jeffrey",
                "org": ""
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2012
    },
    "6K92L4aK": {
        "id": "6K92L4aK",
        "title": "Mechanics of two interacting magma\u2010driven fractures: A numerical study",
        "abstract": "",
        "keywords": [
            "numerical simulation"
        ],
        "authors": [
            {
                "name": "xi zhang",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "andrew p bunger",
                "org": "university of pittsburgh"
            },
            {
                "name": "robert g jeffrey",
                "org": "commonwealth scientific and industrial research organisation"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2014
    },
    "iIJqgXx1": {
        "id": "iIJqgXx1",
        "title": "Numerical studies on crack problems in three-layered elastic media using an image method",
        "abstract": "",
        "keywords": [
            "residual stress",
            "dislocations",
            "fundamental solution",
            "functional imaging"
        ],
        "authors": [
            {
                "name": "xi zhang",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "robert g jeffrey",
                "org": "commonwealth scientific and industrial research organisation"
            }
        ],
        "venue": "International Journal of Fracture",
        "year": 2006
    },
    "78OFOCHU": {
        "id": "78OFOCHU",
        "title": "A pseudo-3D model for hydraulic fracture growth in a layered rock",
        "abstract": "Abstract   This paper presents a new pseudo-3D (P3D) model for a hydraulic fracture growing in a layered rock with contrasts in both material properties and in situ stresses. In the model, the vertically planar fracture is divided along the lateral direction into cells. Within each cell, the cross-sectional deformation is plane strain, and the fluid pressure is allowed to vary vertically. The cells are discretized by displacement discontinuity elements that are formulated to include the elastic layered effect. The fluid flow in the cell is in two directions. Along the central part, which is of uniform pressure, the fluid flow is lateral, corresponding to the main component of fluid transport. Near the vertical fracture edge of a cell, the flow can be vertical and is generated by the vertical pressure gradient. This part of the cell is called the filling part. When the pressure in the filling part reaches the level equal to that in the central part, the flow direction switches from vertical to lateral. The filling and central parts both contribute to fracture height growth. The proposed P3D problem is solved in a coupled manner that accounts for the two-directional flow and cross-sectional deformation through a two-loop iterative method. In the outer loop, the fluid storage of the central part is updated by satisfying mass conservation in the lateral direction, and in the inner loop, the cross-sectional elastic deformation and the influxes to the filling parts are found by satisfying energy minimization subject to an equality constraint on the central-part volume of a cell. The results of pressure ad fracture width at a given elapsed time are thus obtained. After that, fracture growth in both lateral and vertical directions is controlled by the fracture toughness criterion based on linear elasticity. In describing the P3D model, the governing equations are provided and their dimensionless forms are derived. The numerical algorithm used for solving the P3D problem is also described. Numerical examples are presented, including a constant-height fracture, a radial one and asymmetric fractures in three-layered rocks. Comparisons of our results are made with other published results and good agreements between them are found.",
        "keywords": "",
        "authors": [
            {
                "name": "Xi Zhang",
                "org": "CSIRO Energy, Melbourne, Australia"
            },
            {
                "name": "Bisheng Wu",
                "org": "CSIRO Energy, Melbourne, Australia"
            },
            {
                "name": "Robert G. Jeffrey",
                "org": ""
            },
            {
                "name": "Luke D. Connell",
                "org": "CSIRO Energy, Melbourne, Australia"
            },
            {
                "name": "Guangqing Zhang",
                "org": ""
            }
        ],
        "venue": "International Journal of Solids and Structures",
        "year": 2017
    },
    "osxvJiOd": {
        "id": "osxvJiOd",
        "title": "Changes of slip rate and slip\u2010plane orientation by fault geometrical complexities during fluid injection",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Xi Zhang",
                "org": "CSIRO Energy Melbourne Australia"
            },
            {
                "name": "Bisheng Wu",
                "org": "State Key Laboratory of Hydroscience and Engineering, Department of Hydraulic Engineering, Tsinghua University, Beijing, China"
            },
            {
                "name": "Robert G. Jeffrey",
                "org": "SCT Operation Ltd. Wollongong Australia"
            },
            {
                "name": "Diansen Yang",
                "org": "State Key Laboratory of Geomechanics and Geotechnical Engineering, Institute of Rock and Soil Mechanics, Chinese Academy of Sciences, Wuhan, China."
            },
            {
                "name": "Weizhong Chen",
                "org": "State Key Laboratory of Geomechanics and Geotechnical Engineering, Institute of Rock and Soil Mechanics, Chinese Academy of Sciences, Wuhan, China."
            },
            {
                "name": "Fengshou Zhang",
                "org": "(Department of Geotechnical Engineering, Tongji University, Shanghai, China.)"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2019
    },
    "9fYGFq2w": {
        "id": "9fYGFq2w",
        "title": "Analytical predictions for a natural spacing within dyke swarms",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "andrew bunger",
                "org": ""
            },
            {
                "name": "thierry menand",
                "org": ""
            },
            {
                "name": "alexander r cruden",
                "org": ""
            },
            {
                "name": "xi zhang",
                "org": ""
            },
            {
                "name": "henry halls",
                "org": ""
            }
        ],
        "venue": "Earth and Planetary Science Letters",
        "year": 2013
    },
    "Ao2jeYGw": {
        "id": "Ao2jeYGw",
        "title": "Swarm Theory, Hydraulic Fracturing, and the Emergence of Natural Spacing within Dyke Swarms",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Andrew P. Bunger",
                "org": "University of Pittsburgh Department of Civil and Environmental Engineering Pittsburgh PA USA"
            },
            {
                "name": "Thierry Menand",
                "org": "Universit\u00e9 Blaise Pascal\u2013CNRS\u2013IRD Laboratoire Magmas et Volcans France"
            },
            {
                "name": "Alexander R. Cruden",
                "org": "Monash University School of Geosciences Melbourne Australia"
            },
            {
                "name": "Xi Zhang",
                "org": "CSIRO Manufacturing and Infrastructure Technology"
            },
            {
                "name": "Henry C. Halls",
                "org": "University of Toronto at Mississauga Department of Chemical and Physical Sciences Mississauga Ontario Canada"
            }
        ],
        "venue": "Acta Geologica Sinica-english Edition",
        "year": 2016
    },
    "5JNzfFil": {
        "id": "5JNzfFil",
        "title": "Reinitiation or termination of fluid-driven fractures at frictional bedding interfaces: FLUID-DRIVEN FRACTURE GROWTH",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Xi Zhang",
                "org": ""
            },
            {
                "name": "Robert G. Jeffrey",
                "org": ""
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2008
    },
    "ZR5LqAtM": {
        "id": "ZR5LqAtM",
        "title": "An analytical thermo-poro-elasticity model for the mechanical responses of a wellbore and core during overcoring",
        "abstract": "Abstract   To accurately measure in situ stresses using overcore techniques, the key is to find the relationship between the stresses and measured strains on the wellbore wall and on the core at two stages, i.e. before and after overcoring. For gas shales, where there exist large pressure and temperature changes, we developed an analytical model for the stage before overcoring to study the evolution of all field variables, i.e. temperature, pressure, stress, strain and displacement (TPSSD), when an inclined wellbore is drilled in an infinite and homogenous thermo-poro-elastic media (THM) subjected to three far-field principal stresses, whose axes may not coincide with the horizontal and vertical planes. In that paper we investigated the thermal and poro-elastic effects on the strain changes around and especially at the wellbore wall. As an extension of the previous work. In this paper, we describe an analytical model to give the mechanical responses of the wellbore and core for the stage after overcoring. Strain changes at the wellbore wall are examined in detail because these are measured by the overcore method. By using the analytical solutions presented at a specific time and the strains before overcoring as an initial state, the transient solutions for the evolution of temperature, pressure, stress, strain and displacement (TPSSD) are obtained so that for the two critical stages before and after overcoring a reasonable estimate of the in situ stresses can be obtained. As well as the strain changes, the temperature and pressure at the wellbore wall, which vary with time, are also required to find in situ stresses in the inverse model. Fortunately, their effects become progressively less important with time due to the small size of overcored sample. The critical time is calculated when the thermal and porous effects can be ignored. Two cases, i.e. constant and exponentially time-varying temperature boundary conditions, are investigated.",
        "keywords": "",
        "authors": [
            {
                "name": "Bisheng Wu",
                "org": "CSIRO Energy, 71 Normanby Road, Clayton, VIC 3168, Australia"
            },
            {
                "name": "Ranjith Pathegama Gamage",
                "org": "Department of Civil Engineering, Monash University, Victoria 3800, Australia"
            },
            {
                "name": "Xi Zhang",
                "org": "CSIRO Energy, 71 Normanby Road, Clayton, VIC 3168, Australia"
            },
            {
                "name": "Robert G. Jeffrey",
                "org": ""
            },
            {
                "name": "Ken Mills",
                "org": "SCT Operations, Wollongong 2500, Australia"
            },
            {
                "name": "Xishu Wang",
                "org": "CSIRO Energy, 71 Normanby Road, Clayton, VIC 3168, Australia"
            }
        ],
        "venue": "International Journal of Rock Mechanics and Mining Sciences",
        "year": 2017
    },
    "PNRO0smV": {
        "id": "PNRO0smV",
        "title": "A model for hydraulic fracture growth across multiple elastic layers",
        "abstract": "Abstract   Typical stress conditions in gas reservoirs consisting of multiple thin coal seams interlayed with shales, tuffs and sandstones, often lead to generation of a planar vertical hydraulic fracture. A pseudo-3D model, in which the growth of the planar hydraulic fracture occurs through multiple horizontal layers with different elastic properties, is developed to account for the effects of modulus contrasts on fracture shapes. In this model, plane strain deformation is assumed for pseudo-3D cells that have uniform cross-sectional pressure distribution, and the horizontal fluid flow is simplified to be one dimensional. The vertical and horizontal fracture growth are controlled in the model by two failure criteria, respectively. Viscous fluid friction effects are included for vertical growth and a correction factor is applied to the horizontal failure criterion to adjust the propagation speeds. The numerical results for different values of the correction factor are presented for a vertically planar fracture propagating in a homogeneous rock subject to stress contrasts. Fitting the pseudo-3D results to fully-3D results provides a means to determine the correlation factor that is found to be a function of material constants and cell length. The correlation factor obtained is then extended to hydraulic fracture propagation in a layered rock mass. There are two options in choosing material constants for the correlation factor and their results are examined. Both choices demonstrate the same varying trends for fracture height and propagation speed. The existence of softer coal seams retards upward fracture growth, with a stepwise injection pressure associated with the discontinuous upward growth.",
        "keywords": "",
        "authors": [
            {
                "name": "Xi Zhang",
                "org": "CSIRO Energy, Melbourne, VIC, Australia"
            },
            {
                "name": "Bisheng Wu",
                "org": "CSIRO Energy, Melbourne, VIC, Australia"
            },
            {
                "name": "Luke D. Connell",
                "org": "CSIRO Energy, Melbourne, VIC, Australia"
            },
            {
                "name": "Yanhui Han",
                "org": "Aramco Services, Houston, USA"
            },
            {
                "name": "Robert G. Jeffrey",
                "org": ""
            }
        ],
        "venue": "Journal of Petroleum Science and Engineering",
        "year": 2018
    },
    "c8vLBSTF": {
        "id": "c8vLBSTF",
        "title": "A numerical model for the effect of permeability change on faulting during fluid injection",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Xi Zhang",
                "org": "CSIRO Energy Melbourne Australia"
            },
            {
                "name": "Robert G. Jeffrey",
                "org": "SCT Operations Pty Ltd Wollongong Australia"
            },
            {
                "name": "Changrong He",
                "org": "State Key Laboratory of Earthquake Dynamics, Institute of Geology, China Earthquake Administration Beijing China"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2019
    },
    "LLfwpwNC": {
        "id": "LLfwpwNC",
        "title": "Role of overpressurized fluid and fluid-driven fractures in forming fracture networks",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xi zhang",
                "org": ""
            },
            {
                "name": "robert g jeffrey",
                "org": ""
            }
        ],
        "venue": "Journal of Geochemical Exploration",
        "year": 2014
    },
    "OYx4tfvU": {
        "id": "OYx4tfvU",
        "title": "Numerical methods for hydraulic fracture propagation: A review of recent trends",
        "abstract": "Development of numerical methods for hydraulic fracture simulation has accelerated in the past two decades. Recent advances in hydraulic fracture modeling and simulation are driven by increased industry and research activity in oil and gas, a drive toward consideration of more complex behaviors associated with layered and naturally-fractured rock formations, and a deepening understanding of the underlying mathematical model and its intrinsic challenges. Here we review the basic approaches being employed. Some of these comprise enhancements of classical methods, while others are imported from other fields of mechanics but are completely new in their application to hydraulic fracturing. After a description of the intrinsic challenges associated with the mechanics of fluid-driven fractures, we discuss both continuum and meso-scales numerical methods as well as engineering models which typically make use of additional assumptions to reduce computational cost. We pay particular attention to the verification and validation of numerical models, which is increasingly enabled by an ever-expanding library of laboratory experiments and analytical solutions for simple geometries in a number of different propagation regimes. A number of challenges remain and are amplified with a drive toward fully-coupled, three-dimensional hydraulic fracture modeling that accounts for host-rock heterogeneity. In the context of such a drive to complex models, we argue that the importance of best-practice development that includes careful verification and validation is vital to ensure progress is constrained by the appropriate underlying physics and mathematics with a constant attention to identifying conditions under which simpler models suffice for the intended modeling purposes.",
        "keywords": "",
        "authors": [
            {
                "name": "Brice Lecampion",
                "org": "Geo-Energy Lab - Gaznat Chair on Geo-Energy, Swiss Federal Institute of Technology in Lausanne, EPFL-ENAC-IIC-GEL, Station 18, Lausanne CH-1015, Switzerland"
            },
            {
                "name": "Andrew P. Bunger",
                "org": "Department of Civil and Environmental Engineering, University of Pittsburgh, PA, USA"
            },
            {
                "name": "Xi Zhang",
                "org": "CSIRO Energy, Clayton, Vic, Australia"
            }
        ],
        "venue": "Journal of Natural Gas Science and Engineering",
        "year": 2018
    },
    "IKDNwq36": {
        "id": "IKDNwq36",
        "title": "Perturbation analysis for predicting the temperatures of water flowing through multiple parallel fractures in a rock mass",
        "abstract": "",
        "keywords": [
            "runge kutta method"
        ],
        "authors": [
            {
                "name": "bisheng wu",
                "org": ""
            },
            {
                "name": "xi zhang",
                "org": ""
            },
            {
                "name": "robert g jeffrey",
                "org": ""
            },
            {
                "name": "andrew p bunger",
                "org": ""
            },
            {
                "name": "cameron huddlestoneholmes",
                "org": ""
            }
        ],
        "venue": "International Journal of Rock Mechanics and Mining Sciences",
        "year": 2015
    },
    "i0LrXsOb": {
        "id": "i0LrXsOb",
        "title": "Fluid-driven nucleation and propagation of splay fractures from a permeable fault: Splay Fracture Nucleation and Growth",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Xi Zhang",
                "org": "CSIRO Energy; Melbourne Australia"
            },
            {
                "name": "Robert G. Jeffrey",
                "org": "CSIRO Energy; Melbourne Australia"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2016
    },
    "djCK2daC": {
        "id": "djCK2daC",
        "title": "A Preliminary Study on Damage Wave in Elastic-brittle Materials",
        "abstract": "",
        "keywords": [
            "constitutive model",
            "wave propagation",
            "energy dissipation",
            "microstructures",
            "thermodynamics",
            "chemical reaction",
            "elastic energy",
            "numerical simulation"
        ],
        "authors": [
            {
                "name": "jin lu",
                "org": ""
            },
            {
                "name": "xi zhang",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "yiuwing mai",
                "org": "center for advanced materials"
            }
        ],
        "venue": "International Journal of Damage Mechanics",
        "year": 2005
    },
    "4a1y8k5s": {
        "id": "4a1y8k5s",
        "title": "Parameters Affecting the Interaction Among Closely Spaced Hydraulic Fractures",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "andrew p bunger",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "xi zhang",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "robert g jeffrey",
                "org": "commonwealth scientific and industrial research organisation"
            }
        ],
        "venue": "Spe Journal",
        "year": 2012
    },
    "qGeK43z7": {
        "id": "qGeK43z7",
        "title": "Finite-Element Simulation of a Hydraulic Fracture Interacting With a Natural Fracture",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Zuorong Chen",
                "org": "CSIRO"
            },
            {
                "name": "Robert G. Jeffrey",
                "org": "SCT Operations"
            },
            {
                "name": "Xi Zhang",
                "org": "CSIRO"
            },
            {
                "name": "James Kear",
                "org": "CSIRO"
            }
        ],
        "venue": "Spe Journal",
        "year": 2017
    },
    "Q7V2MpbT": {
        "id": "Q7V2MpbT",
        "title": "Mechanics of two interacting magma-driven fractures: A numerical study: two-dike interaction",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "robert g jeffrey",
                "org": ""
            },
            {
                "name": "andrew bunger",
                "org": ""
            },
            {
                "name": "xi zhang",
                "org": ""
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2014
    },
    "X1WP1Vl4": {
        "id": "X1WP1Vl4",
        "title": "Review of plausible chemical migration pathways in Australian coal seam gas basins",
        "abstract": "Abstract   Coal seam gas (CSG) or coal bed methane production has grown exponentially in Australia over the last two decades with currently nearly 7000 productive wells and another 18,750 wells planned over the next five to ten years. To address concerns over environmental contamination by hydraulic fracture fluids (HFF) attributed to (i) incidents involving poor surface handling of HFF and other fluids with potential migration pathways in soil and shallow groundwater, and (ii) leakage pathways arising from HFF injection into coal seams and unintended migration of these chemicals, the  National assessment of chemicals associated with coal seam gas extraction in Australia  (the  Assessment ) was undertaken. The  Assessment  included a review of international studies on unconventional gas migration pathways to provide prior knowledge and comparison for use in the Australian study. The international literature highlighted that accidents with HFF were mainly due to surface operations and included leaking equipment and spills. Contamination risks of groundwater from hydraulic fracturing itself were found to be very small based on analysis of micro-seismic and groundwater hydrochemistry data; geologic modelling of vertical fracture growth further reveals a low risk of leakage pathways developing in aquifers confined by deep shale formations. This is due to limitations on the fracture growth vertically across aquitards often hundreds of meters thick, retention within the shale of limited amounts of injected fluid, and preferential fracture growth at shallow depths in the horizontal direction. These arguments are broadly applicable to Australian CSG basins. However, important differences exist, such as the reduced thickness in Australia of the aquitards that separate the targeted gas resource from groundwater. Also, hydraulic fracturing in Australian coal seams is practised only when permeabilities are too low for gas extraction to be economical without stimulation. From the nearly 10,000 CSG wells drilled in the Bowen and Surat Basins in Queensland, only 6% have received hydraulic fracturing to date. The reduced risk of leakage pathways developing during CSG production in Australian basins is further corroborated by geologic criteria based on modelling and observations. Criteria include encountering certain favourable conditions during drilling/injection, i.e. (i) interfaces, such as natural fractures, faults, and bedding planes, which promote offsetting and branching, or rock layers with higher fracture toughness causing the cessation or reduction in fracture growth, (ii) narrow fractures due to a relatively higher elastic modulus, leading to higher viscous flow loss, (iii) high permeability layers, and (iv) overlying layer(s) with a higher confining stress. In addition to the leakage pathways considered in North American shale gas basins involving (i) pre-existing fractures and faults, or (ii) flow up the production well due to poor casing or cementing, plausible chemical migration pathways in Australian CSG basins are due to (iii) connectivity via a fracture in or extended out of the coal seam formation between CSG wells and water bores co-located in the same formation, and (iv) poor integrity water bores enhancing inter-aquifer connectivity. These plausible pathways are described and used in subsequent work as the basis of risk assessments for contamination at the local- and regional scale.",
        "keywords": "",
        "authors": [
            {
                "name": "Dirk Mallants",
                "org": "CSIRO, Private Bag 2, Glen Osmond, SA 5064, Australia"
            },
            {
                "name": "Robert G. Jeffrey",
                "org": ""
            },
            {
                "name": "Xi Zhang",
                "org": "CSIRO, Private Bag 10, Clayton, VIC 3169, Australia"
            },
            {
                "name": "Bailin Wu",
                "org": "CSIRO, Private Bag 10, Clayton, VIC 3169, Australia"
            },
            {
                "name": "James Kear",
                "org": "CSIRO, Private Bag 10, Clayton, VIC 3169, Australia"
            },
            {
                "name": "Zuorong Chen",
                "org": "CSIRO, Private Bag 10, Clayton, VIC 3169, Australia"
            },
            {
                "name": "Bisheng Wu",
                "org": "CSIRO, Private Bag 10, Clayton, VIC 3169, Australia"
            },
            {
                "name": "Elise Bekele",
                "org": "CSIRO, Private Bag 5, Wembley, WA 6913, Australia"
            },
            {
                "name": "Matthias Raiber",
                "org": "CSIRO, GPO Box 2583, Brisbane, QLD 4001, Australia"
            },
            {
                "name": "Simon C. Apte",
                "org": "CSIRO, New Illawarra Road, Lucas Heights, NSW 2234, Australia"
            },
            {
                "name": "Bruce Gray",
                "org": "Australian Federal Government, Department of the Environment and Energy, GPO Box 787, Canberra, ACT 2600, Australia"
            }
        ],
        "venue": "International Journal of Coal Geology",
        "year": 2018
    },
    "ZUrM1guM": {
        "id": "ZUrM1guM",
        "title": "Semi-analytical model for a geothermal system considering the effect of areal flow between dipole wells on heat extraction",
        "abstract": "Abstract   Optimization of well placement in a geothermal system is an important topic for maximizing the heat economically extracted from a conductive geothermal reservoir. In order to investigate the role of well placement, this paper presents a semi-analytical model in which fluid circulates in a single, horizontally planar geothermal reservoir with a constant hydraulic aperture via dipole wells in the presence of a 2D areal or regional flow field. By using a new coordinate system based on the velocity potential and the streamline function, analytical solutions in the Laplace space for the temperature field are found, which are then numerically inverted to obtain time-domain results. The effects of some factors such as well separation, areal flow direction, flow rate, and the velocity of the areal flow on heat recovery are investigated. It is found that the dimensionless areal flow velocity, U 0 \u00a0=\u00a0 v   0   \u03c9\u03c0L/Q , and the angle of the areal flow,  \u03b2 , play an important role when changing other parameter to maximize the output temperature and the lifetime of the dipole well system. When U 0 \u00a0\u2264\u00a00.5, the angle for minimizing interflow between wells should be  \u03b2 \u00a0=\u00a00; when 0.5\u00a0 0  \u03b2 \u00a0=\u00a0arccos(0.5U 0 ); when U 0 \u00a0u003e\u00a00.7854, the injection well should be placed downstream from the production well.",
        "keywords": "",
        "authors": [
            {
                "name": "Bisheng Wu",
                "org": "CSIRO Energy, Melbourne, Australia"
            },
            {
                "name": "Guangqing Zhang",
                "org": ""
            },
            {
                "name": "Xi Zhang",
                "org": "CSIRO Energy, Melbourne, Australia"
            },
            {
                "name": "Robert G. Jeffrey",
                "org": ""
            },
            {
                "name": "James Kear",
                "org": "CSIRO Energy, Melbourne, Australia"
            },
            {
                "name": "Tongtiegang Zhao",
                "org": "CSIRO Land and Water, Melbourne, Australia"
            }
        ],
        "venue": "Energy",
        "year": 2017
    },
    "1rXVK3w0": {
        "id": "1rXVK3w0",
        "title": "A model for downhole fluid and rock temperature prediction during circulation",
        "abstract": "",
        "keywords": [
            "scaling",
            "drilling"
        ],
        "authors": [
            {
                "name": "bisheng wu",
                "org": ""
            },
            {
                "name": "xi zhang",
                "org": ""
            },
            {
                "name": "robert g jeffrey",
                "org": ""
            }
        ],
        "venue": "Geothermics",
        "year": 2014
    },
    "HG48gOPi": {
        "id": "HG48gOPi",
        "title": "A semi-analytic solution of a wellbore in a non-isothermal low-permeability porous medium under non-hydrostatic stresses",
        "abstract": "",
        "keywords": [
            "analytical solution",
            "scaling",
            "latent heat"
        ],
        "authors": [
            {
                "name": "bisheng wu",
                "org": ""
            },
            {
                "name": "xi zhang",
                "org": ""
            },
            {
                "name": "robert g jeffrey",
                "org": ""
            }
        ],
        "venue": "International Journal of Solids and Structures",
        "year": 2012
    },
    "jOFPENLn": {
        "id": "jOFPENLn",
        "title": "Constraints on Simultaneous Growth of Hydraulic Fractures from Multiple Perforation Clusters in Horizontal Wells",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "andrew p bunger",
                "org": "university of pittsburgh"
            },
            {
                "name": "robert g jeffrey",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "xi zhang",
                "org": "commonwealth scientific and industrial research organisation"
            }
        ],
        "venue": "Spe Journal",
        "year": 2014
    },
    "AGxvDLF4": {
        "id": "AGxvDLF4",
        "title": "Fluid\u2010driven multiple fracture growth from a permeable bedding plane intersected by an ascending hydraulic fracture",
        "abstract": "",
        "keywords": [
            "crack propagation"
        ],
        "authors": [
            {
                "name": "xi zhang",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "robert g jeffrey",
                "org": "commonwealth scientific and industrial research organisation"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2012
    },
    "uyoSJ5OV": {
        "id": "uyoSJ5OV",
        "title": "Geomechanics of fracture caging in wellbores",
        "abstract": "",
        "keywords": [
            "geomechanics",
            "equations of state"
        ],
        "authors": [
            {
                "name": "ruud weijermars",
                "org": ""
            },
            {
                "name": "xi zhang",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "dan schultzela",
                "org": "colorado mesa university"
            }
        ],
        "venue": "Geophysical Journal International",
        "year": 2013
    },
    "rVvEo5tw": {
        "id": "rVvEo5tw",
        "title": "Analytical solutions for an extended overcore stress measurement method based on a thermo-poro-elastic analysis",
        "abstract": "Abstract   A theoretical generalized plane-strain thermo-poro-elastic (THM) wellbore model is developed for application to the conventional overcore stress measurement method, under the situations when the thermal effect cannot be decoupled from the measured strains on the borehole walls. The THM theory developed by Coussy is used to describe the effects of both the pore pressure and the temperature on the stress and strain distributions around an inclined wellbore, which is assumed to be drilled instantly and subjected to initial stresses with arbitrary directions. The Laplace transformation is used to obtain the temperature, pressure, displacement, strain and stresses in the three-dimensional state around the wellbore. As special cases, the solutions of the above field variables are also provided for the poro-elastic (HM), thermo-elastic (TM) and pure elastic (CM) cases. Based on the THM solutions obtained, the stresses at the borehole wall, which vary with time, provide a bridge to find the in situ stresses from the measured strains at the wellbore surface. In this THM overcore stress measurement method, the temperature and the pressure (if a fluid is present) at the wellbore wall are another two parameters that need to be measured for stress inversion.",
        "keywords": "",
        "authors": [
            {
                "name": "Bisheng Wu",
                "org": "CSIRO Energy, Melbourne, Australia"
            },
            {
                "name": "Xi Zhang",
                "org": "CSIRO Energy, Melbourne, Australia"
            },
            {
                "name": "Robert G. Jeffrey",
                "org": ""
            },
            {
                "name": "Ken Mills",
                "org": "SCT Operations, Wollongong, Australia"
            }
        ],
        "venue": "International Journal of Rock Mechanics and Mining Sciences",
        "year": 2016
    },
    "0zVkdaX6": {
        "id": "0zVkdaX6",
        "title": "Mechanics of edge crack growth under transient pressure and temperature conditions",
        "abstract": "",
        "keywords": [
            "dimensional analysis"
        ],
        "authors": [
            {
                "name": "xi zhang",
                "org": ""
            },
            {
                "name": "robert g jeffrey",
                "org": ""
            },
            {
                "name": "bisheng wu",
                "org": ""
            }
        ],
        "venue": "International Journal of Solids and Structures",
        "year": 2015
    },
    "JeGZJDsX": {
        "id": "JeGZJDsX",
        "title": "A Transient Analytical Model for Predicting Wellbore/Reservoir Temperature and Stresses during Drilling with Fluid Circulation",
        "abstract": "Accurate characterization of heat transfer in a wellbore during drilling, which includes fluid circulation, is important for wellbore stability analysis. In this work, a pseudo-3D model is developed to simultaneously calculate the heat exchange between the flowing fluid and the surrounding media (drill pipe and rock formation) and the in-plane thermoelastic stresses. The cold drilling fluid descends through the drill pipe at constant injection rates and returns to the ground surface via the annulus. The fluid circulation will decrease the wellbore bottom temperature and reduce the near-wellbore high compressive stress, potentially leading to tensile fracturing of the well. The governing equations for the coupled heat transfer stress problem are formulated to ensure that the most important parameters are taken into account. The wellbore is subject to a non-hydrostatic in situ far-field stress field. In modeling heat exchange between fluid and surrounding media, the heat transfer coefficients are dependent on fluid properties and flow behavior. Analytical solutions in the Laplace space are obtained for the temperatures of the fluid in both the drill pipe and annulus and for the temperature and stress changes in the formation. The numerical results in the time domain are obtained by using an efficient inversion approach. In particular, the near-well stresses are compared for the cases with fixed and time-dependent cooling wellbore conditions. This comparison indicates that the using a fixed temperature wellbore conditions may over-estimate or under-estimate the bottom-hole stress change, potentially leading to wellbore stability problems.",
        "keywords": "",
        "authors": [
            {
                "name": "Bisheng Wu",
                "org": ""
            },
            {
                "name": "Tianle Liu",
                "org": ""
            },
            {
                "name": "Xi Zhang",
                "org": ""
            },
            {
                "name": "Bailin Wu",
                "org": ""
            },
            {
                "name": "Robert G. Jeffrey",
                "org": ""
            },
            {
                "name": "Andrew P. Bunger",
                "org": ""
            }
        ],
        "venue": "Energies",
        "year": 2017
    },
    "VO3hkqpx": {
        "id": "VO3hkqpx",
        "title": "A simplified model for heat extraction by circulating fluid through a closed-loop multiple-fracture enhanced geothermal system",
        "abstract": "Multiple hydraulic fractures have been proposed for improving the performance of an enhanced geothermal system (EGS) by providing conductive flow pathways and increased contact area between flowing fluid and surrounding rock formation. Use of more fractures incurs a higher drilling and hydraulic fracturing cost, but the additional cost can be offset by improved operation performance of an EGS. In this paper, a model is presented for efficiently predicting the output temperature so as to optimize the number of fractures and fracture spacing to maximize the EGS lifetime under a constant circulation rate. This optimal spacing is shown to arise due to the interplay among number of fractures, fracture spacing, well depth, and the pre-existing geothermal gradient. Specifically, under a typical geothermal gradient associated with EGS for a 5km total vertical depth of the well, the number of fractures N and the equal fracture spacing d have optimal values: 6\u2a7dN\u2a7d13 and 30m\u2a7dd\u2a7d90m. In addition, the semi-analytical solution method presented is effective and efficient in computation and, for this reason, is useful for optimizing the design of a geothermal reservoir with multiple layers at equal or non-equal spacing.",
        "keywords": "",
        "authors": [
            {
                "name": "Bisheng Wu",
                "org": "CSIRO Energy, Melbourne, VIC, Australia"
            },
            {
                "name": "Xi Zhang",
                "org": "CSIRO Energy, Melbourne, VIC, Australia"
            },
            {
                "name": "Robert G. Jeffrey",
                "org": ""
            },
            {
                "name": "Andrew P. Bunger",
                "org": "Department of Civil and Environmental Engineering, University of Pittsburgh, Pittsburgh, PA, USA"
            },
            {
                "name": "Shanpo Jia",
                "org": "Research Center of Geomechanics and Geotechnical Engineering, Yangtze University, Jingzhou, Hubei, China"
            }
        ],
        "venue": "Applied Energy",
        "year": 2016
    },
    "zd7Y7Ic2": {
        "id": "zd7Y7Ic2",
        "title": "Experimental Investigation of the Interaction Among Closely Spaced Hydraulic Fractures",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "andrew p bunger",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "robert g jeffrey",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "james kear",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "xi zhang",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "mark a morgan",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2011
    },
    "X5W7UeKa": {
        "id": "X5W7UeKa",
        "title": "Propagation of a fluid-driven penny-shaped fracture parallel to the free-surface of an elastic solid",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xi zhang",
                "org": ""
            },
            {
                "name": "robert g jeffrey",
                "org": ""
            },
            {
                "name": "emmanuel detournay",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "xjNqIj7M": {
        "id": "xjNqIj7M",
        "title": "Mechanics of Hydraulic Fracture Growth From a Borehole",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "robert g jeffrey",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "xi zhang",
                "org": "commonwealth scientific and industrial research organisation"
            }
        ],
        "venue": "",
        "year": 2010
    },
    "nRpPaz56": {
        "id": "nRpPaz56",
        "title": "Wellbore Stability Analyses for HPHT Wells Using a Fully Coupled Thermo-Poroelastic Model",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bailin wu",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "xi zhang",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "robert g jeffrey",
                "org": "commonwealth scientific and industrial research organisation"
            }
        ],
        "venue": "",
        "year": 2011
    },
    "vRbBrxsE": {
        "id": "vRbBrxsE",
        "title": "An Efficient and Accurate Approach for Studying the Heat Extraction from Multiple Recharge and Discharge Wells",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bisheng wu",
                "org": ""
            },
            {
                "name": "xi zhang",
                "org": ""
            },
            {
                "name": "andrew p bunger",
                "org": ""
            },
            {
                "name": "robert g jeffrey",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "5AxaZqlC": {
        "id": "5AxaZqlC",
        "title": "Constraints on Simultaneous Growth of Hydraulic Fractures From Multiple Perforation Clusters in Horizontal Wells",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "robert g jeffrey",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "andrew p bunger",
                "org": "commonwealth scientific and industrial research organisation"
            },
            {
                "name": "xi zhang",
                "org": "commonwealth scientific and industrial research organisation"
            }
        ],
        "venue": "",
        "year": 2013
    },
    "AF75V8al": {
        "id": "AF75V8al",
        "title": "Can Reservoir Conductivity be Enhanced by Shear Fractures Alone?",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xi zhang",
                "org": ""
            },
            {
                "name": "robert g jeffrey",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2011
    },
    "RoWnGfLb": {
        "id": "RoWnGfLb",
        "title": "Research on Influence of Indonesia M_S8.7 Earthquake to Western China Using GPS Data",
        "abstract": "Using the vary original GPS observation data since 1990's in western China,combining with the geological structure and recently earthquakes(M_S\u22656.0) in the same area,the relationship between the background of regional nowadays horizontal crust movement and deformation which are revealed by GPS observation and strong earthquake activity are analyzed.Moreover depending on the emergency GPS observation results in Sichuan-Yunnan area in Jun.2005 after Indonesia M_S 8.7 earthquake,the horizontal movement and deformation characteristic in this area as the far off field response to Indonesia M_S 8.7 earthquake are researched.In this foundation,the infection of Indonesia M_S 8.7 earthquake to earthquake activity tendency in western China are analyzed and discussed.",
        "keywords": [
            "Western China",
            "Earthquake tendency",
            "Indonesia M_S8.7 earthquake",
            "GPS datum"
        ],
        "authors": [
            {
                "name": "WANG Shuang-xu",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an ,China"
            },
            {
                "name": "DING Ping",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an ,China"
            },
            {
                "name": "ZHANG Xiao-liang",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an ,China"
            }
        ],
        "venue": "Northwestern Seismological Journal",
        "year": 2005
    },
    "cDazsCHM": {
        "id": "cDazsCHM",
        "title": "HORIZONTAL MOVEMENT CHARACTERISTICS OF NORTHEASTERN MARGIN OF QINGHAI-TIBET CRUSTAL BLOCKS",
        "abstract": "With the homogeneous elastic strain block model and the horizontal crustal movement velocity field obtained by GPS measurements,the movement parameters and strain parameters of the northeastern margin of the Qinghai-Tibet block are calculated.The uniform deformation of the blocks,and the relative boundary motion between the adjacent blocks including strike-slip and extrusion rate are calculated from the each block movement parameters and strain parameters.Combining with the tectonic characteristics and GPS velocity profile locating at Haiyuan-Liupan Arc,the present day tectonic activity are discussed.",
        "keywords": [
            "strain model",
            "elastic block",
            "velocity",
            "Qinghai-Tibet block",
            "GPS"
        ],
        "authors": [
            {
                "name": "Jiang Fengyun",
                "org": ") %%#1%%#Second Crust Monitoring and Application Center,CEA,Xi'an  2)Shanxi Institute of Surveying and Mapping of Land,Xi'an )"
            },
            {
                "name": "Zhu Liangyu",
                "org": ") %%#1%%#Second Crust Monitoring and Application Center,CEA,Xi'an  2)Shanxi Institute of Surveying and Mapping of Land,Xi'an )"
            },
            {
                "name": "Wang Shuangxu",
                "org": ") %%#1%%#Second Crust Monitoring and Application Center,CEA,Xi'an  2)Shanxi Institute of Surveying and Mapping of Land,Xi'an )"
            },
            {
                "name": "Zhang Xiaoliang",
                "org": ") %%#1%%#Second Crust Monitoring and Application Center,CEA,Xi'an  2)Shanxi Institute of Surveying and Mapping of Land,Xi'an )"
            },
            {
                "name": "Zhang Xi",
                "org": ") %%#1%%#Second Crust Monitoring and Application Center,CEA,Xi'an  2)Shanxi Institute of Surveying and Mapping of Land,Xi'an )"
            },
            {
                "name": "Song Bingwu",
                "org": ") %%#1%%#Second Crust Monitoring and Application Center,CEA,Xi'an  2)Shanxi Institute of Surveying and Mapping of Land,Xi'an )"
            }
        ],
        "venue": "Journal of Geodesy and Geodynamics",
        "year": 2013
    },
    "wKKA0TxM": {
        "id": "wKKA0TxM",
        "title": "Inversion of Negative Dislocation for Regional Level Observation and Analysis of Strain Accumulation in West Yunnan",
        "abstract": "We used negative dislocation model to inverse the 1981~2006 regional level observation data of West Yunnan on the basis of the stress triggering computation and across-fault observation data,thus studying the strain accumulation status and difference of the tectonic blocks' boundary faults,the time-space evolution and the relationship with the process of the development and occurrence of strong earthquakes.The result shows:(1)in this area,most earthquakes with magnitude over 6 occurred on the locked segments or obviously enhanced locked segments of the blocks' boundary faults and nearby;(2)presently the region south of Binchuan-Nanhua and north of Nanjian and the region from Eryuan to Lijiang reveal the background of obvious strain accumulation,while around the Nandinghe fault appears the strain accumulation to some degree.",
        "keywords": [
            "West Yunnan",
            "stress triggering model",
            "negative dislocation model",
            "regional level",
            "strain accumulation"
        ],
        "authors": [
            {
                "name": "ZHANG Xi",
                "org": "2nd Crust Monitoring and Application Center,CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "JIANG Zai-sen",
                "org": "Institute of Earthquake Prediction,CEA,Beijing ,China"
            },
            {
                "name": "ZHANG Si-xin",
                "org": "2nd Crust Monitoring and Application Center,CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "WANG Shuang-xu",
                "org": "2nd Crust Monitoring and Application Center,CEA,Xi'an ,Shaanxi,China"
            }
        ],
        "venue": "Journal of Seismological Research",
        "year": 2007
    },
    "5hgm6zsZ": {
        "id": "5hgm6zsZ",
        "title": "CHARACTERISTICS OF GPS HORIZONTAL MOVEMENT AND TECTONIC DEFORMATION DURING CURRENT TEN YEARS IN CHINA MAINLAND",
        "abstract": "Using horizontal velocity field result observed by GPS during 1999\u20142009 of China Mainland,the characteristics of horizontal crustal movement and tectonic deformation at main fractures during current 10 years were analyzed,together with co-seismic deformation of the Kunlunshan and Wenchuan earthquakes and their possible influence.The results show that: \u2460Co-seismic deformation of the Kunlunshan and Wenchuan earthquakes was obvious,possibly had promoted fracture activity and strain accumulation,at eastern segment of eastern Kunlunshan fracture,at boundary between Gansu and Sichuan,at boundary between Gansu and Sichuan and Shaanxi,at southern segment of Xianshuihe fracture,at middle-northern segment of Anninghe fracture and its meeting region with Longmenshan fracture,according with their tectonic background to some degree.\u2461The main features of tectonic deformation at main active fractures in China Mainland were consistent with their geological background;for current 10 years,the regions where no earthquakes with Ms\u2265 7 occurred and existed long-time background of earthquake development,mainly were located in the western Xinjiang,the eastern Xizang to the western-southwestern Yunnan,and eastern segment of eastern Kunlunshan fracture,boundary between Gansu and Sichuan,boundary between Gansu and Sichuan and Shaanxi,Anninghe fracture and its nearby.",
        "keywords": [
            "Tectonic deformation",
            "Influence of great earthquakes",
            "GPS",
            "Horizontal movement"
        ],
        "authors": [
            {
                "name": "TANG Hongtao",
                "org": "Second Monitoring and Application Center,CEA.Xi'an ,China"
            },
            {
                "name": "ZHANG Xiaoliang",
                "org": "Second Monitoring and Application Center,CEA.Xi'an ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "Second Monitoring and Application Center,CEA.Xi'an ,China"
            },
            {
                "name": "JIANG Fengyun",
                "org": "Second Monitoring and Application Center,CEA.Xi'an ,China"
            }
        ],
        "venue": "Plateau Earthquake Research",
        "year": 2011
    },
    "pAy20UBS": {
        "id": "pAy20UBS",
        "title": "ON HORIZONTAL CRUST MOVEMENT IN NORTHEASTERN MARGIN OF QINGHAI-TIBET BLOCK WITH 2D FEM",
        "abstract": "By transforming the reference frame of the velocity field of horizontal movement observed by GPS during 1999-2001 and 2001-2004 in the northeastern margin of Qinghai-Tibet block and then deducting the holistic movement of the region from it,the result out velocity field reflecting relative movement in the region is gotten.On the basis of this velocity field and the optimization theory,the segmented displacement of the boundary of the studied area are deduced with two-dimensional finite element model of linear elasticity.Taking the results as boundary constraint and the velocity field of horizontal movement after transforming reference frame as the load of FEM node,the velocity field of horizontal movement in the region is simulated,the principal strain rate field and maximal shear strain rate field are calculated,the variety characteristics of the two rate fields and relation between the variety characteristics and strong earthquake preparation are analyzed.",
        "keywords": [
            "2D FEM(Finite Element method)",
            "reference frame",
            "velocity field of horizontal movement with GPS",
            "crustal deformation",
            "the northeastern margin of Qinghai-Tibet block"
        ],
        "authors": [
            {
                "name": "Jiang Fengyun",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Wang Shuangxu",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Zhang Xi",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Zhang Xiaoliang",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Xue Fuping",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Wang Jiying",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an "
            }
        ],
        "venue": "Journal of Geodesy and Geodynamics",
        "year": 2007
    },
    "nAgIbfuP": {
        "id": "nAgIbfuP",
        "title": "Using GPS Data to Analyze Horizontal Movement and Strain Accumulation in Sichuan-Yunnan and Its Vicinity before and after the Wenchuan Earthquake",
        "abstract": "Based on the horizontal velocity data observed by GPS during 2004-2008,i.e.,before and after the Wenchuan MS8.0 earthquake,in Sihcuan-Yunnan and its vicinity(the southeastern Gansu and the part of Shaanxi),we study the preseismic tectonic deformation features and strain accumulation background,the coseismic deformation and its possible influence area combining with the analysis on the features of evolution of deformation-strain field and the inversion of negative dislocation.We conclude:(1)In the period of 2004-2007,obvious compression change and the phased feature of strain accumulation appeared in the two sides of the central Longmenshan fracture,which revealed the Wenchuan earthquake to a certain extent(it may be the medium-term background information of MS\u22656.0 earthquake).The north-northeast boundary,the middle-west segment of south boundary of the Sichuan-Yunnan rhombus block probably had the background of MS\u22656.0 earthquake preparation.The south-southwestern Yunnan,the area from the east segment of Gansu-Sichuan boundary to Gansu-Sichuan-Shaanxi boundary,and the southern Gansu block reflected the seismogenic information of the earthquake with magnitude about 6.0.(2)In the period of August 2007-June 2008,the Wenchuan earthquake area showed remarkable coseismic thrust and dextral deformation.The effect of the Wenchuan earthquake was comparatively obvious on the strain accumulation of Gansu-Sichuan boundary,Gansu-Sichuan-Shaanxi boundary,the south segment of Xianshuihe fracture and the Y-shape intersection region of fractures,which is possibly shown as a certain increase.",
        "keywords": [
            "negative dislocation",
            "GPS",
            "deformation-strain field",
            "Wenchuan M_S8.0 earthquake",
            "coseismic deformation"
        ],
        "authors": [
            {
                "name": "ZHANG Xi",
                "org": "The Second Monitoring and Application Center,CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "CUI Du-xin",
                "org": "The Second Monitoring and Application Center,CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "WANG Wen-ping",
                "org": "The Second Monitoring and Application Center,CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "JIANG Feng-yun",
                "org": "The Second Monitoring and Application Center,CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "WANG Shuang-xu",
                "org": "The Second Monitoring and Application Center,CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "ZHANG Xiao-liang",
                "org": "The Second Monitoring and Application Center,CEA,Xi'an ,Shaanxi,China"
            }
        ],
        "venue": "Journal of Seismological Research",
        "year": 2008
    },
    "KKnm9gNG": {
        "id": "KKnm9gNG",
        "title": "Inversion of Negative Dislocation for Crustal Horizontal Movement in Middle-southern Segment of the China South-north Seismic Belt",
        "abstract": "Using the velocity field result of horizontal movement observed by GPS in the periods of 1999-2001,2001-2004 and 2004-2007,based on the inversion of aseismic negative dislocation,strain accumulation of the main boundary faults and their time-space evolution features are researched.Possible influences of the MS8.1 earthquake at west the pass of Kunlun Mountains on Nov.14,2001 and the Sumatera MS8.7(Mw9.0) earthquake on Dec.26,2004 are analyzed,together with the strain accumulation background related to the Wenchuan MS8.0 and the Panzhihua-Huili MS6.1 earthquakes in 2008.",
        "keywords": [
            "Negative dislocation",
            "Middle-southern segment of the China South-North Seismic Belt",
            "Influence of great earthquakes",
            "Background",
            "GPS"
        ],
        "authors": [
            {
                "name": "ZHANG Xi",
                "org": "Institute of Earthquake Prediction,CEA,Beijing ,China;The Second Monitoring and Application Center,CEA,Xi\u2032an ,China"
            },
            {
                "name": "JIANG Zai-sen",
                "org": "Institute of Earthquake Prediction,CEA,Beijing ,China"
            }
        ],
        "venue": "Northwestern Seismological Journal",
        "year": 2010
    },
    "elBirvqk": {
        "id": "elBirvqk",
        "title": "Evolution Features of Crustal Horizontal Movement from GPS Observation in Sichuan-Yunnan Region and Its Adjacent Area before and after the Wenchuan Earthquake",
        "abstract": "Based on the horizontal velocity data observed by GPS during 2004-2007 and 2007-2009,before and after the Wenchuan earthquake,in Sichuan-Yunnan region and adjacent area,the tectonic deformation evolution features of the crust and main active fault belts,and possible influence from the Wenchuan great earthquake,are analyzed.The result shows that the Wenchuan earthquake area showed obvious co-seismic thrust and dextral deformation during the period of 2007-2009.The earthquake,in a certain extent,promoted tectonic movements in Gansu-Sichuan boundary area,as well as West Qinling Mountain area and Anninghe-Zemuhe faults.Meanwhile,impacted tectonic movement on Xianshuihe fault with adjustment overall but may increase the southern section of it.",
        "keywords": [
            "Tectonic deformation",
            "The Wenchuan earthquake",
            "GPS",
            "Horizontal movement",
            "Sichuan-Yunnan region and its adjacent area"
        ],
        "authors": [
            {
                "name": "JIA Peng",
                "org": "The Second Monitoring and Application Center,CEA,Xi\u2032an ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "The Second Monitoring and Application Center,CEA,Xi\u2032an ,China"
            },
            {
                "name": "ZHANG Xiao-liang",
                "org": "The Second Monitoring and Application Center,CEA,Xi\u2032an ,China"
            },
            {
                "name": "JIANG Feng-yun",
                "org": "The Second Monitoring and Application Center,CEA,Xi\u2032an ,China"
            }
        ],
        "venue": "Northwestern Seismological Journal",
        "year": 2012
    },
    "uVOVbblZ": {
        "id": "uVOVbblZ",
        "title": "INVERSION OF NON-HOMOGENEOUS NEGATIVE DISLOCATION FOR LONG LEVELING SECTION AT MIDDLE-EASTERN SEGMENTS OF WEIHE FAULT",
        "abstract": "Using vertical deformation data of long-leveling section in recent years at the eastern Guanzhong in Shaanxi province,by the aid of construction and inversion with non-homogeneous negative dislocation model with stratification changes of dislocation and dip angle,the geometry parameters of the middle-eastern segments of Weihe fault are computed.The dynamic evolution of strain energy accumulation and difference between different depths together with the relation to energy release and adjustment influence of the Wenchuan earthquake are studied.The results show as follows: 1)The fault is listric nearly to right angle from earth surface to shallow layer,and the depth is basically consistent with geological data.2) The strain accumulation is mainly located at upper-middle layers,displaying obviously before the Wenchuan earthquake,decreased during 2008-2009 probably related to energy release,with reverse related to adjustment after this earthquake during 2009-2010(possibly promoted the Gaoling 4.4 earthquake);up to 2011,this adjustment situation had not ended completely.",
        "keywords": [
            "inversion",
            "strain energy accumulation",
            "leveling section",
            "non-homogeneous negative dislocation",
            "the Wenchuan earthquake"
        ],
        "authors": [
            {
                "name": "Zhang Xi",
                "org": "Second Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Zhang Sixin",
                "org": "Second Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Li Ruisha",
                "org": "Second Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Tang Hongtao",
                "org": "Second Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Jia Peng",
                "org": "Second Monitoring and Application Center,CEA,Xi'an "
            }
        ],
        "venue": "Journal of Geodesy and Geodynamics",
        "year": 2012
    },
    "pdN9paSC": {
        "id": "pdN9paSC",
        "title": "TIME-SPACE EVOLUTION CHARACTERISTICS OF STRAIN INTENSITY OF QILIANSHAN FAULT ZONE REFLECTED BY INFRARED RANGE-MEASURE",
        "abstract": "Using the new observational data of infrared range-measure crossing Qilianshan fault zone up to 2007,combined with deformation background observed by GPS,the time-space evolution characteristics of strain intensity and their relationship with Yumen Ms5.9 earthquake in 2002 and Minle Ms6.1 earthquake in 2003 were researched.It concluded that: \u2460 From several months to about one year before the earthquakes,the segment of fault(or entire fault zone) where the earthquake took place displayed strain accelerating or higher than other segments,major in compression,some sites over there reflected intensity of the maximal shear strain or compressional superficial strain increasing(its absolute value was about or larger than 2.0),after the earthquake,it decreased or showed tensional turning;\u2461Since the latter half of 2004,the Qilianshan fault zone had resumed the status of stress field mainly reflecting compression,presented features of accumulation of strain and stress to a certain degree.In 2007,the compressional strain of the western segment of this fault zone strengthened obviously.",
        "keywords": [
            "Horizontal deformation",
            "Qilianshan fracture zone",
            "Strain intensity"
        ],
        "authors": [
            {
                "name": "ZHANG Xi",
                "org": "The Second Monitoring and Application Center of CEA,Xi 'an ,China"
            },
            {
                "name": "XUE Fu-ping",
                "org": "The Second Monitoring and Application Center of CEA,Xi 'an ,China"
            }
        ],
        "venue": "Plateau Earthquake Research",
        "year": 2007
    },
    "ejr72APx": {
        "id": "ejr72APx",
        "title": "Coseismic response and influence of the Wenchuan Ms8.0 earthquake revealed by crustal deformation observation",
        "abstract": "Using crustal deformation observation data with diverse space-time scale, including GPS, long-leveling cross-fault, short-leveling and short-baseline cross-fault, the coseismic response of the Wenchuan Ms8.0 earthquake on 12 May 2008 and its influence on neighborhood are researched. The analysis shows that, the earthquake region displayed remarkable coseismic deformation of thrust and dextral slip, this great earthquake obviously effected the region from eastern segment of boundary between Gansu and Sichuan province to boundary where Gansu, Sichuan and Shaanxi meet, and the southern segment of Xianshuihe fault and the Y-character region where it meet Longmenshan fault and Anninghe fault, mainly reflecting possible enhanced action for strain accumulation, to some degree.",
        "keywords": [
            "Coseismic response",
            "Crustal deformation observation",
            "The Wenchuan earthquake"
        ],
        "authors": [
            {
                "name": "Xi Zhang",
                "org": "China Earthquake Administration(^ China Earthquake Administration),Beijing,China"
            },
            {
                "name": "DuXin Cui",
                "org": "Second Monitoring Center Earthquake Administration(Second Monitoring Center Earthquake Administration,The Second Monitoring and Application Center of CEA,Second Monitoring Center),Xi'an,China"
            },
            {
                "name": "SiXin Zhang",
                "org": "Second Monitoring Center Earthquake Administration(Second Monitoring Center Earthquake Administration,The Second Monitoring and Application Center of CEA,Second Monitoring Center),Xi'an,China"
            },
            {
                "name": "Shuangxu Wang",
                "org": "Second Monitoring Center Earthquake Administration(Second Monitoring Center Earthquake Administration,The Second Monitoring and Application Center of CEA,Second Monitoring Center),Xi'an,China"
            }
        ],
        "venue": "Wuhan Daxue Xuebao (Xinxi Kexue Ban)/ Geomatics and Information Science of Wuhan University",
        "year": 2009
    },
    "PylCa5Eh": {
        "id": "PylCa5Eh",
        "title": "Identification of Abnormity and Analysis of Slow Time-Varying Structure for Cross-fault Deformation",
        "abstract": "Using 5 typical observational curve at sites such as Shihuiyaokou,Hongliuxia,Wozitan,Biandukou and Nanying,in the monitoring area of Gansu Province and its boundaries with Ningxia and Qinghai Provinces,the slow time-varying precursor system is constructed,the abnormity is identified,and the possible relationship between the abnormity and preparation of earthquakes around or over 6.0 magnitude are researched.The results show that at the medium and short-term phase before these earthquakes,the maximum module of latent root exceeded 1.0.This method reduced factitious or experiential identification of abnormity relative to analysis of observational curve,also reflects dynamic variation and adaptive features of precursor system structure for cross-fault deformation.",
        "keywords": [
            "Analysis of earthquake examples",
            "Cross-fault deformation",
            "Slow time-varying system structure"
        ],
        "authors": [
            {
                "name": "ZHANG Xi",
                "org": "1 The Second Monitoring and Application Center,CEA,316 Xiying Road,Xi'an ,China"
            },
            {
                "name": "TANG Hongtao",
                "org": "1 The Second Monitoring and Application Center,CEA,316 Xiying Road,Xi'an ,China"
            },
            {
                "name": "JIA Peng",
                "org": "1 The Second Monitoring and Application Center,CEA,316 Xiying Road,Xi'an ,China"
            },
            {
                "name": "Shouwen Gong",
                "org": "Commissariat a L'Energie Atomique CEA(CEA),Gif-sur-Yvette,France"
            }
        ],
        "venue": "Geomatics and Information Science of Wuhan University",
        "year": 2013
    },
    "GGkkHYU9": {
        "id": "GGkkHYU9",
        "title": "Inversion of Negative Dislocation for GPS Horizontal Movement and Features of Strain Accumulation in Main Tectonic Areas of China",
        "abstract": "Firstly,using data of GPS horizontal velocity field in China Mainland from 2009 to 2011,aided by inversion of negative dislocation,we found locked segments with energy accumulation at main fractures in Xinjiang,the northeastern margin of QinghaiTibet Block,SichuanYunnan and the North China Secondly,we studied the accumulation rate and locked depth and difference at different regions or segments of main fractures and their possible relationship with preparation of strong earthquakes The result indicated that:(1) Strainaccumulating rate was the highest in Xinjiang area,average locked depth was about 209 km; Strainaccumulating rate in SichuanYunnan area was the second,average locked depth was about 163 km; There existed strain accumulation to some degree in northeastern margin of QinghaiXizang Block,average locked depth was about 157 km,and the strain accumulation rate in North China was the lowest,average locked depth was 160 km(2)At present,there exited relatively higher energy accumulation in west of Southern Tianshan,the eastern of the boundary between Sichuan and Yunnan,from the middle segment of Honghe Fault to the western Yunnan,the western segment of Qilianshan Fault,the segment of the northern margin fault of West Qinling Mountain near boundary between Gansu and Qinghai,the boundary among Shanxi,Hebei and Inner Mongolia Autonomous",
        "keywords": [
            "inversion for negative dislocation",
            "tectonic faults",
            "GPS",
            "strain accumulation"
        ],
        "authors": [
            {
                "name": "ZHANG Xi",
                "org": "The Second Monitoring and Application Center,CEA,Xian ,Shannxi,China"
            },
            {
                "name": "HAO Ming",
                "org": "The Second Monitoring and Application Center,CEA,Xian ,Shannxi,China"
            },
            {
                "name": "JIA Peng",
                "org": "The Second Monitoring and Application Center,CEA,Xian ,Shannxi,China"
            },
            {
                "name": "CUI Duxin",
                "org": "The Second Monitoring and Application Center,CEA,Xian ,Shannxi,China"
            }
        ],
        "venue": "Journal of Seismological Research",
        "year": 2013
    },
    "Kae3UG4y": {
        "id": "Kae3UG4y",
        "title": "RECENT HORIZONTAL CRUSTAL MOVEMENT AND STRAIN ACCUMULATION IN NORTHEASTERN MARGIN OF QINGHAI-TIBET BLOCK",
        "abstract": "By use of horizontal velocity data observed by GPS during 2001\u20142004 and 2004\u20142007 in the northeastern margin of Qinghai-Tibet block,aided by the negative dislocation model,the characteristics of horizontal crustal movement and the status of strain accumulation of this area are researched and following conclusion are drawn.During the period of 2004\u20142007,the regional stress field,after the adjustment through the Kunlun Mountains,Yumen and Minle earthquakes,entirely reflects re-constructing features in accordance with its long-term background field.The eastern segment of Qilian Mountain fault zone roughly maintains the accumulating background of 2001\u20142004,there appears strengthening in the middle-western segment of Qilian Mountain fracture zone,the southern segment of Zhuanglanghe fault and block of southern Gansu and Hexi corridor relative to 2001\u20142004;the eastern segment of Animaqing fracture zone,the northern foot fault of Qinling Range also present the features of stress-strain accumulation.",
        "keywords": [
            "northeastern margin of Qinghai-Tibet block",
            "GPS",
            "characteristics of horizontal crustal movement",
            "strain accumulation",
            "inversion of negative dislocation"
        ],
        "authors": [
            {
                "name": "Zhang Xi",
                "org": "Institute of Earthquake Science,CEA,Beijing 2)Second Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Zhang Xiaoliang",
                "org": ""
            },
            {
                "name": "Wang Shuangxu",
                "org": ""
            },
            {
                "name": "Jiang Fengyun",
                "org": ""
            }
        ],
        "venue": "Journal of Geodesy and Geodynamics",
        "year": 2008
    },
    "urhP3REk": {
        "id": "urhP3REk",
        "title": "ON STRAIN ACCUMULATION OF RECENT CRUST MOVEMENT IN SICHUAN-YUNNAN AREA",
        "abstract": "By use of the regional leveling and GPS observations in Sichuan-Yunnan area during 1994-2006,aided by the negative dislocation model for the elastic block boundaries,combining with the total characteristics of deformation cross-fault,the recent status and intensity of strain accumulation of tectonic blocks and their boundary faults in Sichuan-Yunnan area are studied.The results show that recent status of tectonic stress in Sichuan-Yunnan area manifes itself in energy accumulation mainly.The strain energy accumulation appears obviously in the Anninghe fault and the regions where it meets Zemuhe fault and Xianshuihe fault,the Yanyuan-Lijiang block and its margins,it may be the medium and short-term precursors of some coming earthquakes.",
        "keywords": [
            "data of GPS and regional leveling",
            "Sichuan-Yunnan area",
            "cross-fault deformation",
            "negative dislocation model",
            "strain accumulation"
        ],
        "authors": [
            {
                "name": "Zhang Xi",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an 2)China Center for Earthquake Disaster Emergency and SAR,Beijing "
            },
            {
                "name": "Zhang Sixin",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an 2)China Center for Earthquake Disaster Emergency and SAR,Beijing "
            },
            {
                "name": "Wang Shuangxu",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an 2)China Center for Earthquake Disaster Emergency and SAR,Beijing "
            },
            {
                "name": "Zhang Xiaoliang",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an 2)China Center for Earthquake Disaster Emergency and SAR,Beijing "
            },
            {
                "name": "Lu Mingyong",
                "org": ""
            },
            {
                "name": "Wang Wenping",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an 2)China Center for Earthquake Disaster Emergency and SAR,Beijing "
            }
        ],
        "venue": "Journal of Geodesy and Geodynamics",
        "year": 2007
    },
    "pxHxneIj": {
        "id": "pxHxneIj",
        "title": "ON CRUSTAL MOVEMENT IN CHINA CONTINENT AND ITS RELATIONSHIP WITH STRONG EARTHQUAKES",
        "abstract": "This paper analyzes spatial distribution of current crustal movement in Chinese mainland, and large areal tectonic deformation background and trend with the GPS data. First, the relationship between distribution of areal horizontal movement and strain rate field and strong earthquake locations is discussed. Second, the principal characteristics of regional deformation field in earthquake process is studied by analyzing dynamic changes of regional deformation field and strain field of strong earthquakes(as the Ms 8.1 earthquake in the west to the Kunlun Mountains Pass). Final, the thought and approach of medium and long-term prediction of strong earthquake location by identificating the seismogenic deformation fields are presented.",
        "keywords": [
            "predicting strong earthquake location",
            "China continent",
            "seismogenic deformation fields",
            "crustal movement",
            "GPS"
        ],
        "authors": [
            {
                "name": "Jiang Zaisen",
                "org": " Institute of Earthquake Prediction, CEA, Beijing 2) First Crust Monitoring and Application Center, CEA, Tianjin 3) Second Crust Monitoring and A pplication Center, CEA, Xi\u2019an 4) Institute of Seismology, CEA, Wuhan 5) Earthquake Administration of Hebei Province,Shijiazhuang "
            },
            {
                "name": "Yang Guohua",
                "org": ""
            },
            {
                "name": "Wang Min",
                "org": " Institute of Earthquake Prediction, CEA, Beijing 2) First Crust Monitoring and Application Center, CEA, Tianjin 3) Second Crust Monitoring and A pplication Center, CEA, Xi\u2019an 4) Institute of Seismology, CEA, Wuhan 5) Earthquake Administration of Hebei Province,Shijiazhuang "
            },
            {
                "name": "Zhang Xi",
                "org": ""
            },
            {
                "name": "Wu Yun",
                "org": ""
            },
            {
                "name": "Fang Ying",
                "org": " Institute of Earthquake Prediction, CEA, Beijing 2) First Crust Monitoring and Application Center, CEA, Tianjin 3) Second Crust Monitoring and A pplication Center, CEA, Xi\u2019an 4) Institute of Seismology, CEA, Wuhan 5) Earthquake Administration of Hebei Province,Shijiazhuang "
            },
            {
                "name": "Wang Shuangxu",
                "org": ""
            },
            {
                "name": "Ping Jianjun",
                "org": ""
            }
        ],
        "venue": "Journal of Geodesy and Geodynamics",
        "year": 2006
    },
    "o1Wlh455": {
        "id": "o1Wlh455",
        "title": "Improvement and seismicity analysis of fault motion coordination ration",
        "abstract": "Based on the concept of fault motion coordination ration (FCR), the paper discussed the effect of the starting point on the result of FCR calculation and proposed a calculation method of FCR using sliding windows and an evaluating index of dispersion. The case study of the Lijiang site indicates that the FCR of Lijiang site distributed more widely and discretely before the M7.0 Lijiang earthquake than after it, which reflected strain accumulation and caused poor movement coordination during the seismogenic period. After the earthquake the fault is in a free activity state, and the accumulated strain energy is released, and 3-component movements are consistent to each other. At present, FCR dispersion of Lijiang is low and fault strain accumulation is also at a low level.",
        "keywords": [
            "Lijiang earthquake Fault motion coordination ration (FCR) Cross-fault measurement Dispersion"
        ],
        "authors": [
            {
                "name": "Li Ruisha",
                "org": " Second Crust Monitoring and Application Center, CEA, Xi\u2032an , China"
            },
            {
                "name": "Zhang Xi",
                "org": " Second Crust Monitoring and Application Center, CEA, Xi\u2032an , China"
            },
            {
                "name": "Jia Xiaodong",
                "org": " Earthquake Administration of Liaoning Province, Shenyang , China"
            },
            {
                "name": "Tang Hongtao",
                "org": " Second Crust Monitoring and Application Center, CEA, Xi\u2032an , China"
            }
        ],
        "venue": "Earthquake Research in China",
        "year": 2013
    },
    "tDc5bSzJ": {
        "id": "tDc5bSzJ",
        "title": "Evaluation for Seismic Monitoring Ability of Crustal Deformation",
        "abstract": "Taking the annual seismicity trend reports from 1992 to 2007 given by Second Monitoring and Application Center,CEA,as statistical sample,the seismic monitoring and annual earthquake prediction for northeast margin of Qinghai-Tibet block using crustal deformation data are tested.The capacity of earthquake prediction using crustal deformation anomalies is evaluated.The results show that there was no pretermission of prediction for moderate-strong earthquake in 16 years,4 events were predicted correctly and 19 times failed,the accuracy ratio of prediction is about 21%.It is indicated that crustal deformation monitoring has good predictive capacity to moderate-strong earthquake.But caused by the uncertainty of corresponding relationship between crustal deformation and earthquake event,the percentage of failure is much higher than one of accuracy.",
        "keywords": [
            "Evaluation",
            "Seismic monitoring",
            "Northeast margin of Qinghai-Tibet block",
            "Crustal deformation",
            "Annual earthquake prediction"
        ],
        "authors": [
            {
                "name": "ZHANG Si-xin",
                "org": "Second Monitoring and Application Center,CEA,Xi'an ,China"
            },
            {
                "name": "WANG Shuang-xu",
                "org": "Second Monitoring and Application Center,CEA,Xi'an ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "Second Monitoring and Application Center,CEA,Xi'an ,China"
            },
            {
                "name": "LIU Li-wei",
                "org": "Second Monitoring and Application Center,CEA,Xi'an ,China"
            }
        ],
        "venue": "Northwestern Seismological Journal",
        "year": 2011
    },
    "2TeCfx0Y": {
        "id": "2TeCfx0Y",
        "title": "Representative value of cross-fault in the northeastern margin of the Qinghai-Tibet block and case analysis of the 2016 Menyuan Ms6.4 earthquake",
        "abstract": "Abstract   The equation for determining cross-fault representative value is calculated based on hanging wall and foot wall reference level surfaces. The cross-fault data reliability are analyzed base on the stability of reference datum and observation points, thereby facilitating plotting of the representative value curves after removing interference. The spatial and temporal characteristics of fault deformation abnormalities before the 2016 Menyuan  M s6.4 earthquake, as well as the fault-movement characteristics reflected by representative value, are summarized. The results show that many site trends had changed 1\u20133 years before the Menyuan  M s6.4 earthquake in the Qilian Fault, reflecting certain background abnormalities. The short-term abnormalities centrally had appeared in the 6 months to 1 year period before the earthquake near and in the neighborhood of the source region, demonstrating a significantly increased number of short-term abnormalities. Many sites near and in the neighborhood of the source region had strengthened inverse activities or had changed from positive to inverse activities in the most recent 2\u20133 years, which reflect stress-field enhancements or adjustment features.",
        "keywords": "",
        "authors": [
            {
                "name": "Ruisha Li",
                "org": "Second Monitoring and Application Center, China Earthquake Administration, Xi'an 710054, China"
            },
            {
                "name": "Xi Zhang",
                "org": "Second Monitoring and Application Center, China Earthquake Administration, Xi'an 710054, China"
            },
            {
                "name": "Shouwen Gong",
                "org": "Second Monitoring and Application Center, China Earthquake Administration, Xi'an 710054, China"
            },
            {
                "name": "Hongtao Tang",
                "org": "Second Monitoring and Application Center, China Earthquake Administration, Xi'an 710054, China"
            },
            {
                "name": "Peng Jia",
                "org": "Second Monitoring and Application Center, China Earthquake Administration, Xi'an 710054, China"
            }
        ],
        "venue": "Geodesy and Geodynamics",
        "year": 2016
    },
    "FIvCAA5F": {
        "id": "FIvCAA5F",
        "title": "Study on the relation of regional deformation anomaly characteristics and earthquakes along South-North seismic belt",
        "abstract": "Using the data of regional leveling network since 1970s and GPS monitoring network since 1990s along the South-North seismic belt and vicinity, combining with geologic structure and recently occurred earthquakes (Ms\u22656.0) in this monitoring area, the basic characteristics of regional deformation anomaly before earthquakes are analyzed. Then, depending on the supporting degree of data, under constraint of GPS or regional leveling observation displacement, and according to division of active massif of \"973\" project as geological basis, the inversion computation of aseismic negative dislocation model is carried out. The relation between deformation state of active massif and boundary fault structure reflected by numerical simulation results and seismicity is studied. Based on this, the anomaly characteristics and possible mechanism of regional horizontal and vertical tectonic deformation are qualitatively and horizontal and vertical tectonic deformation are qualitatively and quantitive studied. Some criteria of regional tectonic deformation anomalies before strong earthquakes are preliminary summarized on the basis of regional leveling, GPS observation and numerical simulation.",
        "keywords": [
            "Earthquake anomaly criterion",
            "Inversion of aseismic negative dislocation model",
            "Regional deformation anomaly characteristics",
            "South-North seismic belt"
        ],
        "authors": [
            {
                "name": "WANG Shuang-xu",
                "org": "Commissariat a L'Energie Atomique CEA(CEA),Gif-sur-Yvette,France"
            },
            {
                "name": "Xi Zhang",
                "org": "Commissariat a L'Energie Atomique CEA(CEA),Gif-sur-Yvette,France"
            },
            {
                "name": "ZHANG Si-xin",
                "org": "Commissariat a L'Energie Atomique CEA(CEA),Gif-sur-Yvette,France"
            },
            {
                "name": "ZHANG Xiao-liang",
                "org": "Commissariat a L'Energie Atomique CEA(CEA),Gif-sur-Yvette,France"
            },
            {
                "name": "XUE Fu-ping",
                "org": "Commissariat a L'Energie Atomique CEA(CEA),Gif-sur-Yvette,France"
            }
        ],
        "venue": "Earthquake",
        "year": 2006
    },
    "AgPHFFhJ": {
        "id": "AgPHFFhJ",
        "title": "One Approach for Predicting Earthquake Risk Area from Synthesizing Fixed-point Precursory Anomalies",
        "abstract": "Precursory anomalies of deformation and fluid measured in fixed-point appear the trend features of moving and concentrating from distance areas to the near of seismic area before the Zhangbei MS6.2 earthquake in 1998.Constructing abnormal signal spreading function,and using grid searching-quasi Newton least square method,we inverse the converged region of precursory anomalies which is the predicting possible risk region.The result shows that the distance between the margin of calculated converged region and the real epicenter is only 25-51 km.The difference between the converging time and the original time is only several days.Moreover,the converging rate speeds up at the middle-short term before Zhangbei MS6.2 earthquake.",
        "keywords": [
            "inversion",
            "fixed-point precursor abnormity",
            "earthquake risk area",
            "spreading function"
        ],
        "authors": [
            {
                "name": "ZHANG Xi",
                "org": "Second Crust Deformation Monitoring and Application Center,CEA,Xi-an ,Shannxi,China"
            },
            {
                "name": "LI Rui-sha",
                "org": "Second Crust Deformation Monitoring and Application Center,CEA,Xi-an ,Shannxi,China"
            },
            {
                "name": "TANG Hong-tao",
                "org": "Second Crust Deformation Monitoring and Application Center,CEA,Xi-an ,Shannxi,China"
            },
            {
                "name": "JIA Peng",
                "org": "Second Crust Deformation Monitoring and Application Center,CEA,Xi-an ,Shannxi,China"
            }
        ],
        "venue": "Journal of Seismological Research",
        "year": 2012
    },
    "zqFjiw7x": {
        "id": "zqFjiw7x",
        "title": "Study on the Relations Between Distribution of Crustal Move-ment and Strong Earthquakes Using GPS Survey",
        "abstract": "In this paper,the method of modeling crustal movement and obtaining different spatial strain field is briefly introduced.This method uses GPS data and least square collocation.It is based on different reference benchmark,different kinematics and geometry deformation.In the meantime,the data used include regional network and permanent station of Crustal Movement Observation Network of China.Finally,the relations between crustal movement and strong earthquake are discussed.The relations include the crustal movement obtained by GPS survey data and the time-spatial distribution of geometry deformation in the investigated region.",
        "keywords": [
            "least square collocation",
            "crustal movement",
            "GPS",
            "strong earthquake"
        ],
        "authors": [
            {
                "name": "Jiang Zaisen",
                "org": " Institute of Earthquake Science,CEA,Beijing ,"
            },
            {
                "name": "Yang Guohua",
                "org": " First Crustal Monitoring and Application Center,CEA,Tianjin "
            },
            {
                "name": "Fang Ying",
                "org": " Institute of Earthquake Science,CEA,Beijing ,"
            },
            {
                "name": "Zhang Xi",
                "org": " Second Crustal Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Wu Yanqiang",
                "org": " Institute of Earthquake Science,CEA,Beijing ,; First Crustal Monitoring and Application Center,CEA,Tianjin "
            },
            {
                "name": "Ping Jianjun",
                "org": " Earthquake Administration of Hebei Province,Shijiazhuang "
            }
        ],
        "venue": "Recent Developments in World Seismology",
        "year": 2007
    },
    "BES3naq0": {
        "id": "BES3naq0",
        "title": "Cross-Fault Deformation Anomaly and Confirm Each Other with the Fixed-point Precursors Observation before Yumen and Minle Earthquakes",
        "abstract": "A certain number and significant across-fault short leveling deformation anomaly were observed in the source region around a dozen hundred km range before Yumen MS5.9 earthquake in 2002,Minle MS6.1 and MS5.8 earthquakes in 2003 and Minxian MS5.2 earthquake in 2003.The main abnormal morphology were acceleration,sudden jump or sharp point sudden jump,with mid-term background or short-term precursors significant.Anomalies reflect that the fault first enhanced inverse then changed to relaxation,earthquakes usually happened when the fault change relaxation.The spatial distribution and occurrence time of anomaly have added and confirmed significance to precursor anomalies of fixed-points.",
        "keywords": [
            "Minle MS6.1 and MS5.8 earthquake",
            "Cross-fault deformation",
            "Yumen MS5.9 earthquake",
            "Precursor anomaly of fixed-point",
            "Short leveling mobile deformation observation"
        ],
        "authors": [
            {
                "name": "LI Rui-sha",
                "org": "The Second Monitoring and Application Center,CEA,Xi\u2032an ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "The Second Monitoring and Application Center,CEA,Xi\u2032an ,China"
            },
            {
                "name": "JIA Peng",
                "org": "The Second Monitoring and Application Center,CEA,Xi\u2032an ,China"
            }
        ],
        "venue": "Northwestern Seismological Journal",
        "year": 2012
    },
    "2Y0wktj0": {
        "id": "2Y0wktj0",
        "title": "The Influence of the Kunlun Mountains and Wenchuan Strong Earthquakes on the Crustal Movement and Strain Accumulation in the Northeastern Margin of Qinghai-Xizang Block",
        "abstract": "Making full use of crustal deformation data obtained from GPS,regional leveling and cross-fault means,aided by the inversion of negative dislocation,and combined with seismic activities,the authors studied the influence of the Ms8.1 Kunlun Mountains Great Earthquake of November 14,2001 on the crustal movement and strain accumulation in the northeastern margin of Qinghai-Xizang block.The result shows that it was the adjustment action of disturbance stress field caused by this enormous seismic energy releasing inside Qinghai-Xizang block in the northeastward compressional background field that led to the variation of the crustal difference movement and the stress-strain state in the block boundary.To some extent and for a period of time,the action mainly found expression in the reduction of strain accumulation in the eastern segment of the Altyn Tagh fault and the western segment of the Qilian Mountain fracture zone,and in the promotion of strain accumulation in the middle-eastern segments of the Qilian Mountain fracture zone.Presently the regional stress field of the study area reflects the recovering state after the Kunlun Mountains,Yumen and Minle earthquakes.Moreover,based on limited data obtained from GPS,short-leveling and cross-fault means after the Wenchuan Earthquake of May 12,2008,the authors consider that the Wenchuan Earthquake promoted the strain accumulation in the eastern segment of the Gansu-Sichuan boundary as well as along the Gansu-Sichuan-Shaanxi boundary.",
        "keywords": [
            "the Ms8.1 Kunlun Mountains earthquake",
            "northeastern margin of Xinghai-Xizang block",
            "the Ms8.0 Wenchuan earthquake",
            "influence of great earthquakes",
            "crustal movement"
        ],
        "authors": [
            {
                "name": "ZHANG Xi",
                "org": " No.2 Monitoring Center,China Earthquake Administration,Xi'an,Shaanxi "
            },
            {
                "name": "WANG Shuang-xu",
                "org": " No.2 Monitoring Center,China Earthquake Administration,Xi'an,Shaanxi "
            },
            {
                "name": "ZHANG Xiao-liang",
                "org": " No.2 Monitoring Center,China Earthquake Administration,Xi'an,Shaanxi "
            },
            {
                "name": "CUI Du-xin",
                "org": " No.2 Monitoring Center,China Earthquake Administration,Xi'an,Shaanxi "
            },
            {
                "name": "WANG Wen-ping",
                "org": " No.2 Monitoring Center,China Earthquake Administration,Xi'an,Shaanxi "
            },
            {
                "name": "ZHANG Si-xin",
                "org": " No.2 Monitoring Center,China Earthquake Administration,Xi'an,Shaanxi "
            },
            {
                "name": "XUE Fu-ping",
                "org": " No.2 Monitoring Center,China Earthquake Administration,Xi'an,Shaanxi "
            }
        ],
        "venue": "Acta Geoscientica Sinica",
        "year": 2010
    },
    "K3Nd9DXD": {
        "id": "K3Nd9DXD",
        "title": "Fault deformation anomaly and medium and short-term prediction of Jingtai MS5. 9 earthquake",
        "abstract": "The time-space distribution characteristics of fault deformation anomaly in the near-source region and its outlying zone in the seismogenic process of Jingtai MS5. 9 earthquake occurred on June 6, 2000 in Gansu province is studied preliminarily. The distribution scope of fault deformation anomaly before the earthquake is wide, the anomaly shape is complicated and the pattern anomalous zone of fault deformation (strain) information index is obvious. The shape and amplitude of fault deformation anomaly in different regions differ significantly, which is closely related to the tectonic location of anomaly. The fault deformation anomaly of \u03b1,\u03b2 and \u03b3 phases along the western segment of Haiyuan fault zone shows the process from the quasi-linearity to non-linearity of fault movement in the near-source region, matches the high-value anomalous area of fault deformation (strain) information index, and reflects the high strain accumulation in the seismogenic region. However, the anomaly of abrupt jump and cusp with a large amplitude occurred in the areas far from the earthquake, such as Liupanshan fault zone which is the tectonic convergent section does not reflect the strain accumulation of its location, maybe it is a sign that the regional tectonic stress field is strengthened in the seismogenic process. Based on the above-mentioned facts and combined with the preliminary summary of experiences and lessons in the medium and short-term prediction of Jingtai Ms5. 9 earthquake, we study and explore the application of fault deformation anomaly to earthquake judgement.",
        "keywords": [
            "Anomaly characteristics",
            "Fault deformation",
            "Jingtai MS5. 9 earthquake",
            "Medium and short-term earthquake prediction"
        ],
        "authors": [
            {
                "name": "Wang Shuangxu",
                "org": "China Earthquake Administration(^ China Earthquake Administration),Beijing,China"
            },
            {
                "name": "Jiang Zaisen",
                "org": "China Earthquake Administration(^ China Earthquake Administration),Beijing,China"
            },
            {
                "name": "Chen Wensheng",
                "org": "China Earthquake Administration(^ China Earthquake Administration),Beijing,China"
            },
            {
                "name": "Zhang Xi",
                "org": "China Earthquake Administration(^ China Earthquake Administration),Beijing,China"
            },
            {
                "name": "Chen Bing",
                "org": "China Earthquake Administration(^ China Earthquake Administration),Beijing,China"
            },
            {
                "name": "Zhang Sixin",
                "org": "China Earthquake Administration(^ China Earthquake Administration),Beijing,China"
            },
            {
                "name": "Wang Jiying",
                "org": "China Earthquake Administration(^ China Earthquake Administration),Beijing,China"
            }
        ],
        "venue": "Acta Seismologica Sinica",
        "year": 2001
    },
    "oGhRAVzE": {
        "id": "oGhRAVzE",
        "title": "Application Study of Least Square Collocation in Fixed Point Deformation Characteristic Curve and Anomaly Identification",
        "abstract": "The Gauss-Function covariance model based on least square collocation was applied in the anomaly assisted identification of fixed point deformation characteristic curves. We used two different examples to show that the filtering,interpolation and extrapolation of least square collocation can be simulated the trend of fixed point deformation curves and assisted searching their anomaly characteristics in short-,medium-and long-term. The least square collocation method has certain significance for identifying the fixed point deformation.",
        "keywords": [
            "extrapolation",
            "least square collocation",
            "fitting",
            "fixed point deformation"
        ],
        "authors": [
            {
                "name": "JIA Peng",
                "org": "The Second Monitoring and Application Center,CEA,Xi'an ,Shannxi,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "The Second Monitoring and Application Center,CEA,Xi'an ,Shannxi,China"
            },
            {
                "name": "TANG Hong-tao",
                "org": "The Second Monitoring and Application Center,CEA,Xi'an ,Shannxi,China"
            },
            {
                "name": "LI Rui-sha",
                "org": "The Second Monitoring and Application Center,CEA,Xi'an ,Shannxi,China"
            }
        ],
        "venue": "Journal of Seismological Research",
        "year": 2013
    },
    "93HifywR": {
        "id": "93HifywR",
        "title": "STUDY ON RELATION BETWEEN FAULT ACTIVITY AND EARTHQUAKE IN SICHUAN-YUNNAN REGION",
        "abstract": "This paper choses 16 cross-fault deformation observation points in Sichuan-Yunnan region,for analyzing the quantitative relation between the relative sliding of fault plane and relative displacement of the sites on the two walls on ground surface and then calculates the amounts of horizontal twist,vertical displacement and the ratio between them,and analyzs the relation between the ratio and the earthquake activity simply.",
        "keywords": [
            "fault activity",
            "earthquake",
            "Sichuan-Yunnan area",
            "cross-fault observation",
            "deformation"
        ],
        "authors": [
            {
                "name": "Li Ruisha",
                "org": "Second Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Zhang Xi",
                "org": "Second Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Wang Shuangxu",
                "org": "Second Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Zhang Sixin",
                "org": "Second Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Xue Fuping",
                "org": "Second Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Wang Jiying",
                "org": "Second Monitoring and Application Center,CEA,Xi'an "
            }
        ],
        "venue": "Journal of Geodesy and Geodynamics",
        "year": 2009
    },
    "SDmFrPsY": {
        "id": "SDmFrPsY",
        "title": "Research on Horizontal Crust Movement in Qinghai-Tibet Block with 2D Finite Element Method",
        "abstract": "Transforming the reference frame of the velocity field of horizontal movement observed by GPS from 1998 to 2003 in the Qinghai-Tibet Block and deducting the holistic movement from it,we get the velocity field reflecting relative movement in this region.On the basis of this velocity field and according to the optimization theory,we deduce the segmented displacements of the boundary of the studied area with two-dimensional finite element model of linear elasticity.Taking the results as boundary constraint,we rebuild the velocity field of horizontal movement,the strain rate field and surface dilation rate in the region.The relationship between the location of potential strong earthquake and the strain rate field and deformation field in the area of tectonic structure are analyzed.",
        "keywords": [
            "optimization theory",
            "2D Finite Element method",
            "Qinghai-Tibet Block",
            "GPS",
            "strong earthquake"
        ],
        "authors": [
            {
                "name": "JIANG Feng-yun",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "ZHANG Xiao-liang",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "WANG Shuang-xu",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "GENG Xiao-min",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an ,Shaanxi,China"
            }
        ],
        "venue": "Journal of Seismological Research",
        "year": 2009
    },
    "W3h9SHba": {
        "id": "W3h9SHba",
        "title": "CHARACTERISTICS OF CRUSTAL DYNAMIC EVOLUTION REVEALED BY GPS OBSERVATION BEFORE WENCHUAN 8.0 EARTHQUAKE",
        "abstract": "By using the GPS velocity fields of China mainland in three time periods since 1999,the characteristics of crustal dynamic evolution before Wenchuan Ms8.0 earthquake was studied.From the results following knowledges can be drawn.1)The Wenchuan earthquake had taken place in the zone where crustal squeezed movements were blocked obviously.There was a large obstacle existed in the seismogenic zone,and the fault nearby the epicenter was in strong blocking state for many years.2)With the Wenchuan earthquake approaching,the compressive zone in the west to epicenter gradually expanded to east obviously.In some local areas,the direction of principal compressive strain deflected northward,and right lateral shear slip enhanced obviously.3)The sectional features of coseismic deformation in Whenchuan earthquake and 6.0 or more aftershock distribution were closely related to the sectional movement deformation of the fault and its vicinal zone.",
        "keywords": [
            "GPS velocity field",
            "Wenchuan 8.0 earthquake",
            "crustal movement and deformation",
            "dynamic evolution",
            "fault"
        ],
        "authors": [
            {
                "name": "Zhang Xiaoliang",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Zhang Xi",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Wang Shuangxu",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Jiang Fengyun",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Zhu Liangyu",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an "
            }
        ],
        "venue": "Journal of Geodesy and Geodynamics",
        "year": 2011
    },
    "SjzBHN3c": {
        "id": "SjzBHN3c",
        "title": "ANALYSIS OF CRUSTAL VERTICAL DEFORMATION BEFORE AND AFTER WENCHUAN Ms8.0 EARTHQUAKE",
        "abstract": "Using regional leveling and fault-crossing leveling data the crustal vertical deformation has been analyzed before and after Wenchuan Ms8.0 earthquake.The results show that before the earthquake the regional deformation were staged,in detail,its differential elevation and subsidence weakened and the movement of Longmenshan fault turned from active to locked,after the earthquake,the earthquake effect spreaded north-east ward along the Longmenshan fault mainly and the co-seismic deformation nearby the after shock region was obvious.",
        "keywords": [
            "Wenchuan Ms8.0 earthquake",
            "Longmenshan fault",
            "vertical deformation",
            "fault-crossing leveling",
            "evolution"
        ],
        "authors": [
            {
                "name": "Zhang Sixin",
                "org": "Second Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Zhang Xi",
                "org": "Second Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Wang Shuangxu",
                "org": "Second Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Liu Liwei",
                "org": "Second Monitoring and Application Center,CEA,Xi'an "
            }
        ],
        "venue": "Journal of Geodesy and Geodynamics",
        "year": 2008
    },
    "QQQh8UB8": {
        "id": "QQQh8UB8",
        "title": "VERTICAL CRUST DEFORMATION BEFORE AND AFTER MINLE-SHANDAN Ms6.1 EARTHQUAKE ON OCTOBER 25,2003",
        "abstract": "Using observations of regional leveling, cross-faults leveling and fault deformation in the northern Qinghai-Tibet block, the vertical crust deformation before and after Minle-Shandan Ms6.1 earthquake on October 25, 2003 is analyzed. The results show that: there are obvious anomalous characteristics in long-medium-term and short-impending stage before earthquake;after slower deformation stage from 1995 to 2000, the deformation accelerated in middle and west part of Qilian fault zone from 2000 to 2002,the quantity of anomalies had gone through a evolutive process of \u201csmall-large-small\u201d from March to October in 2003,and the fault deformation anomaly has the characteristic that it contracts from the outside to the source region.After the event there has been the contrary deformation in the middle and the west part of Qilian fault zone and a rise region appears in the east segment.",
        "keywords": [
            "cross-fault zone leveling",
            "Minle-Shandan Ms6.1 earthquake",
            "vertical deformation field",
            "fault deformation",
            "evolution"
        ],
        "authors": [
            {
                "name": "Zhang Sixin",
                "org": "Second Crust Monitoring and Application Center, CEA, Xi\u2019an "
            },
            {
                "name": "Wang Shuangxu",
                "org": "Second Crust Monitoring and Application Center, CEA, Xi\u2019an "
            },
            {
                "name": "Zhang Xi",
                "org": "Second Crust Monitoring and Application Center, CEA, Xi\u2019an "
            }
        ],
        "venue": "Journal of Geodesy and Geodynamics",
        "year": 2006
    },
    "BmjJEV1H": {
        "id": "BmjJEV1H",
        "title": "United Inversion of Three-dimensional Negative Dislocation for GPS and Leveling Observation in Northeastern Margins of Qinghai-Tibet Block",
        "abstract": "By using data observed by GPS and leveling with different distribution density in northeastern margins of Qinghai-Tibet block during 1999\u20142004,united inversion of three-dimensional negative dislocation model is realized,and the status and difference of strain accumulation of different segments of block boundary faults are studied.It can be concluded that:presently the eastern segment of Qilianshan fault zone and its boundary region with Zhuanglanghe fault and Haiyuan fault is in an obvious background of strain accumulation;Lanzhou and Linxia area near the southern segment of Zhuanglanghe fault display a feature of strain accumulation in certain degree.",
        "keywords": [
            "united inversion",
            "leveling",
            "GPS",
            "three-dimensional negative dislocation model"
        ],
        "authors": [
            {
                "name": "Zhang Xi",
                "org": " Second Crust Monitoring and Application Center,CEA,Xi'an ,China,"
            },
            {
                "name": "Jiang Zaisen",
                "org": " Institute of Earthquake Science,CEA,Beijing ,China"
            },
            {
                "name": "Wang Shuangxu",
                "org": " Second Crust Monitoring and Application Center,CEA,Xi'an ,China,"
            },
            {
                "name": "Zhang Xiaoliang",
                "org": " Second Crust Monitoring and Application Center,CEA,Xi'an ,China,"
            },
            {
                "name": "Zhang Sixin",
                "org": " Second Crust Monitoring and Application Center,CEA,Xi'an ,China,"
            }
        ],
        "venue": "Recent Developments in World Seismology",
        "year": 2007
    },
    "SV8kokS5": {
        "id": "SV8kokS5",
        "title": "Research on the Dividing Method for Present Regional Active Block",
        "abstract": "In this paper,a new idea combing Quasi-Accurate Detection of gross errors and discontinuous deformation positive analysis to divide regional active blocks is brought forward.The idea can fetch up the demarcation of active blocks on the lack of observation area and get the demarcation of active blocks of full research area.Otherwise,using the Shichuan-Yunnan area as an example,the practice process of the method is introduced.",
        "keywords": [
            "Quasi-Accurate Detection(QUAD))method Discontinuous deformation positive analysis The dividing of active blocks Shichuan-Yunnan area"
        ],
        "authors": [
            {
                "name": "Zhang Xiaoliang",
                "org": ""
            },
            {
                "name": "Jiang Zaisen",
                "org": ""
            },
            {
                "name": "Chen Bing",
                "org": ""
            },
            {
                "name": "Wang Qi",
                "org": ""
            },
            {
                "name": "Zhang Xi",
                "org": ""
            }
        ],
        "venue": "Earthquake Research In China",
        "year": 2005
    },
    "vWEukRKR": {
        "id": "vWEukRKR",
        "title": "Features of Current Horizontal Movement Observed by GPS and Influence of the Great Wenchuan Earthquake in the Northeastern margin of Qinghai-xizang block",
        "abstract": "Using the GPS observational data during the period of 2004\uff5e2007 and 2007\uff5e2009 in the northeastern margin of Qinghai-Tibet block,the evolution features of crustal movement and tectonic deformation of active fractures are analyzed,together with the influence of the Wenchuan Earthquake.The result shows that,this earthquake did not display remarkable effect on the Qilianshan-Haiyuan fracture belt from observation result of limit stations,which still reflected thrust and sinistral slip,with according to its tectonic background;but displayed relatively obvious influence on the West Qinling tectonic region,the medium-southern segments of Liupanshan fault,the west segments of Northern foot fault of Qinling and Weihe fault,mainly revealing enganced strain accumulation on the middle-eastern West Qinling tectonic region,mainly revealing adjusting-distrubing effect on other fault-segments.",
        "keywords": [
            "Northeastern margin of Qinghai-Xizang block",
            "Wenchuan Earthquake",
            "GPS"
        ],
        "authors": [
            {
                "name": "ZHANG Xi",
                "org": "The Second Monitoring and Application Center of CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "ZHANG Xiao-liang",
                "org": "The Second Monitoring and Application Center of CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "ZHANG Si-xin",
                "org": "The Second Monitoring and Application Center of CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "WANG Shuang-xu",
                "org": "The Second Monitoring and Application Center of CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "JIANG Feng-yun",
                "org": "The Second Monitoring and Application Center of CEA,Xi'an ,Shaanxi,China"
            }
        ],
        "venue": "Journal of Seismological Research",
        "year": 2010
    },
    "1OQp7vG4": {
        "id": "1OQp7vG4",
        "title": "The Simulation on Listric-fault Dislocation Background and Co-seismic Deformation of the Wenchuan Earthquake",
        "abstract": "Using long-leveling section observation data crossing Longmenshan fault during the period of 1983-1997 and 1997(or 2007)-2008,aided by positive and negative dislocation model of pure thrust and spade-fault,in combination with the method for grid-searching and testing,the authors simulated the locked energy background before the Wenchuan Ms8.0 great earthquake of Sichuan Province on 12 May,2008 and its co-seismic deformation.The energy accumulation before this earthquake and co-seismic rebounding of Central Longmenshan fault are revealed to some extent.",
        "keywords": [
            "Wenchuan great earthquake",
            "long-leveling section",
            "occurrence background",
            "listric dislocation"
        ],
        "authors": [
            {
                "name": "ZHANG Xi",
                "org": " Second Monitoring and Application Center,China Earthquake Administration,Xi'an,Shaanxi "
            },
            {
                "name": "WANG Qing-liang",
                "org": " Second Monitoring and Application Center,China Earthquake Administration,Xi'an,Shaanxi "
            },
            {
                "name": "TANG Hong-tao",
                "org": " Second Monitoring and Application Center,China Earthquake Administration,Xi'an,Shaanxi "
            },
            {
                "name": "JIA Peng",
                "org": " Second Monitoring and Application Center,China Earthquake Administration,Xi'an,Shaanxi "
            }
        ],
        "venue": "Acta Geoscientica Sinica",
        "year": 2011
    },
    "BboPVfo1": {
        "id": "BboPVfo1",
        "title": "Analysis on the Section Deformation and Strain Accumulation of the Fen-Wei Fracture Belt Observed by GPS in Recent 10 Years",
        "abstract": "Using velocity-field data observed by GPS from 1999 to 2009 in the Fen-Wei Fracture Belt,we study the features of the dynamic evolution of the cross-fracture section deformation,the difference of strain accumulation between fracture segments,and the possible influence of the MS8.0 Wenchuan Earthquake on the Belt.The result shows that in recent 10 years,the southern segment of the Shanxi Fracture and the middle-eastern Weihe Basin displayed relatively faster strain-accumulation,the southern margin fault of the Weiguang Basin and the western segment of the Weihe fracture also existed strain accumulation to some extent.All these variation obviously resulted from the Wenchuan Earthquake.From 2007 to 2009,the strain accumulation increased in the western segment of the Weihe Fracture,the southern segment of the Shanxi Fracture and the southern fault in the margin of the Weiguang Basin.",
        "keywords": [
            "influence of great earthquake",
            "the Fen-Wei Fracture Belt",
            "section deformation",
            "GPS",
            "strain accumulation"
        ],
        "authors": [
            {
                "name": "ZHANG Xi",
                "org": "The Second Monitoring and Application Center,CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "JIANG Feng-yun",
                "org": "The Second Monitoring and Application Center,CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "TANG Hong-tao",
                "org": "The Second Monitoring and Application Center,CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "LI Rui-sha",
                "org": "The Second Monitoring and Application Center,CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "JIA Peng",
                "org": "The Second Monitoring and Application Center,CEA,Xi'an ,Shaanxi,China"
            }
        ],
        "venue": "Journal of Seismological Research",
        "year": 2011
    },
    "CXDS8jYg": {
        "id": "CXDS8jYg",
        "title": "NEGATIVE DISLOCATION MODEL OF VERTICAL CRUSTAL MOVEMENT AND BACKGROUND BEFORE WENCHUAN AND PANZHIHUA EARTHQUAKES",
        "abstract": "By use of the regional leveling observations of the western Sichuan in the periods of 1990\u20141997,1997\u20142003 and 1994\u20142006 and the aid of inversion of negative dislocation,the characteristics of tectonic deformation and strain accumulation background of correlative and neighbor faults before the Wenchuan M s8.0 earthquake and the Panzhihua M s6.1 earthquake are researched.It is concluded that there is obvious uplift in the large region according with its background of successive movement and long-term(over 10 years) strain accumulation on the northern segment of Anninghe fault and the southern segment of Xianshuihe fault and the region they meet Longmenshan fault,reflecting the background of the Wenchuan M s8.0 earthquake to some extent.Moreover,the acceleration of stain accumulation during 1997\u20142003 on the southern segment of Yuanmou-luzhijiang fault may reflect the background of the Panzhihua M s6.1 earthquake.",
        "keywords": [
            "Wenchuan M s8.0 earthquake",
            "background",
            "negative dislocation",
            "vertical deformation",
            "Panzhihua M s6.1 earthquake"
        ],
        "authors": [
            {
                "name": "Zhang Xi",
                "org": "Institute of Earthquake Prediction,CEA,Beijing 2)Second Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Zhang Sixin",
                "org": ""
            },
            {
                "name": "Wang Shuangxu",
                "org": ""
            }
        ],
        "venue": "Journal of Geodesy and Geodynamics",
        "year": 2009
    },
    "XgqIzQBO": {
        "id": "XgqIzQBO",
        "title": "Inversion of Seismic Parameters of the Wenchuan Earthquake and Analysis on Variation of its Coulomb Stress Based on GPS observation",
        "abstract": "In this paper,using the GPS observational data before and after the great Wenchuan earthquake on 12 May 2008,aided by rectangle dislocation model,the seismic parameters of this earthquake are obtained.Applying these parameters,the variation of Coulomb rupture static stress caused by this earthquake,is acted on its peripheral fault segments reflecting strain accumulation,before this earthquake revealed by the inversion of negative dislocation from GPS data.The influences of this great earthquake on strain accumulation of peripheral tectonic faults are researched.The result shows that,this earthquake region displayed remarkable co-seismic deformation of thrust and dextral slip.This great earthquake affected the eastern boundary where Gansu and Sichuan provinces meet and the boundary where Gansu,Sichuan and Shaanxi provinces meet,together with the southern segment of Xianshuihe fault and the northern end of Anninghe fault,to some degree,mainly reflecting possible enhanced action for strain accumulation.",
        "keywords": [
            "dislocation",
            "parameters inversion",
            "Coulomb stress",
            "the great Wenchuan earthquake"
        ],
        "authors": [
            {
                "name": "ZHANG Xi",
                "org": "Institute of Earthquake Prediction of CEA,Beijing ,China;The Second Monitoring and Application Center of CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "CUI Du-xin",
                "org": "The Second Monitoring and Application Center of CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "JIANG Feng-yun",
                "org": "The Second Monitoring and Application Center of CEA,Xi'an ,Shaanxi,China"
            }
        ],
        "venue": "Journal of Seismological Research",
        "year": 2009
    },
    "NWOz0rPI": {
        "id": "NWOz0rPI",
        "title": "APPLICATION OF DEFORMATION RATE ACCUMULATION FOR CROSS-FAULT LEVELING IN NORTHEASTERN MARGINS OF QINGHAI-TIBET BLOCK",
        "abstract": "Six cross-fault leveling data of thirty years in northeastern margins of Qinghai-Tibet block with the method of Deformation Rate Accumulation are analyzed,and the experience and method for extracting anomaly information are discussed,the relevant earthquake cases within 400 km are gathered and analyzed,the experience and characteristics of deformation rate accumulation show: \u2460Anomaly accumulation chart is more prominent and intuitive than primary curve;\u2461Only out-of-range and continuous anomaly data is cumulated,and discontinuous anomaly data isn't cumulated;\u2462From the time that beginning of anomaly to the earthquakes,this method can be the medium-term indicator of the earthquake prediction.",
        "keywords": [
            "Cross-Fault leveling",
            "Rate accumulation",
            "Anomaly analysis",
            "Earthquake prediction"
        ],
        "authors": [
            {
                "name": "TANG Hongtao",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an ,China"
            },
            {
                "name": "JIA Peng",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an ,China"
            },
            {
                "name": "LI Ruisha",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an ,China"
            }
        ],
        "venue": "Plateau Earthquake Research",
        "year": 2012
    },
    "kUq1Mplx": {
        "id": "kUq1Mplx",
        "title": "GENERALITY AND INDIVIDUALITY OF SEISMIC DEFORMATION BACKGROUND ANOMALY IN VARIOUS TECTONIC CONDITIONS",
        "abstract": "By use of the repeated observational data of regional leveling network since 1970s and combining with the geologic tectonic and the recent earthquakes(Ms\u22656.0) in the monitored area, the distribution of the background abnormity of vertical deformation before and after strong earthquakes in different tectonic conditions of Qilianshan-Hexi corridor and Chuandian areas are analyzed emphaticaly, and compared with several typical seismic cases in North China.The generality and individuality characteristics of background abnormity of regional vertical deformation related to earthquake genesis in various tectonic conditions are summarized.Finally its mechanism and the meaning for forecasting the place where strong earthquakes occur are discussed.",
        "keywords": [
            "universality and individuality",
            "various tectonic conditions",
            "seismic deformation abnormity",
            "strong earthquake forecasting",
            "North-South Seismic Belt"
        ],
        "authors": [
            {
                "name": "Wang Shuangxu",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi\u2019an "
            },
            {
                "name": "Zhang Sixin",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi\u2019an "
            },
            {
                "name": "Zhang Xi",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi\u2019an "
            },
            {
                "name": "Xue Fuping",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi\u2019an "
            },
            {
                "name": "Jiang Fengyun",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi\u2019an "
            }
        ],
        "venue": "Journal of Geodesy and Geodynamics",
        "year": 2008
    },
    "pzYaS0JU": {
        "id": "pzYaS0JU",
        "title": "Application of Hilbert-Huang Transform in Data Processing of Earth Tide Deformation",
        "abstract": "We introduce basic principles and implementation of Hilbert-Huang Transform method and analyze applicability and stability of this method in signal simulation processing.Studying the impact of step,jump and random noise on HHT analysis of analog signal,the results show that the method has high time-frequency resolution,reflect to the typical abnormal in the precursor data such as steps or jumps significantly,and has good stability,and is able to separate the signal which is higher than the 2 times standard deviation of the noise effectively.Finally,we verify the applicability of the method in the analysis of precursor data by using two cases and find that the HHT method can identify the tidal from the real observational data effectively,and have some reference meaning for disturbing rejection and extracting exception.",
        "keywords": [
            "empirical mode decomposition",
            "precursor data analysis",
            "Hilbert-Huang Transform",
            "time-frequency analysis"
        ],
        "authors": [
            {
                "name": "LI Rui-sha",
                "org": "Second Crust Deformation Monitoring and Application Center,CEA,Xi-an ,Shannxi,China"
            },
            {
                "name": "WU Yan-qiang",
                "org": "Institute of Earthquake Science,CEA,Beijing ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "Second Crust Deformation Monitoring and Application Center,CEA,Xi-an ,Shannxi,China"
            }
        ],
        "venue": "Journal of Seismological Research",
        "year": 2012
    },
    "CDOGUySo": {
        "id": "CDOGUySo",
        "title": "Quantitative analysis for tectonic deformation on active rupture zones",
        "abstract": "On the basis of the regional GPS data with a higher spatial resolution, we present a quantitative analysis method for tectonic deformation of active rupture zones in order to predict the location of forthcoming great earthquakes. Firstly we divide the main fault area into certain deformation units; then derive the geometric deformation and relative dislocation parameters of each unit; and finally quantitatively estimate the slip and strain rates in each segment of the rupture zone. Furthermore, by comparing the consistency of deformation in all segments of the whole rupture zone, we can determine the possible a-nomalous segments as well as their properties and amplitudes. In analyzing the east boundaries of Sichuan-Yunnan block with reference to the GPS velocity data in the period of 1991-2001, we have discovered that the Mianning-Ningnan-Dongchuan segment on the Zemuhe-Xiaojiang fault zone is relatively locked and the left-lateral shear strain rate here is higher.",
        "keywords": [
            "Active rupture zone",
            "GPS",
            "Prediction for great earthquake location",
            "Tectonic deformation"
        ],
        "authors": [
            {
                "name": "Zai-sen Jiang",
                "org": "China Earthquake Administration(^ China Earthquake Administration),Beijing,China"
            },
            {
                "name": "An-fu Niu",
                "org": "China Earthquake Networks Center(China Earthquake Networks Center),,China"
            },
            {
                "name": "Min Wang",
                "org": "China Earthquake Administration(^ China Earthquake Administration),Beijing,China"
            },
            {
                "name": "Kai-wu Li",
                "org": "China Earthquake Administration(^ China Earthquake Administration),Beijing,China"
            },
            {
                "name": "Ying Fang",
                "org": "China Earthquake Administration(^ China Earthquake Administration),Beijing,China"
            },
            {
                "name": "Xi Zhang",
                "org": "China Earthquake Administration(^ China Earthquake Administration),Beijing,China"
            },
            {
                "name": "Xiao-liang Zhang",
                "org": "China Earthquake Administration(^ China Earthquake Administration),Beijing,China"
            }
        ],
        "venue": "Acta Seismologica Sinica",
        "year": 2005
    },
    "Y66u5taO": {
        "id": "Y66u5taO",
        "title": "STUDY ON RELATION BETWEEN VARIATION OF LOCAL GEOID AND EARTHQUAKE BY REPEATED GRAVITY SURVEY",
        "abstract": "On the basis of the repeated observational data of seismic gravity network since 1990s in Qilianshan-Hexi area,the changes of local geoid in different time scale are calculated with Bruns formula and approximately solution of Stokes' integral those are usually used for getting the difference of geoid from gravity field model.The variation of local geoid and the relation to geologic tectonic and seismicity are researched.The conclusions are that the general shape of local geoid variation in Qilianshan-Hexi area has divisional property,and the evolvement of local geoid for different periods is nonstationary.The detail variation of local geoid is related to the position of earthquakes from the data before several Ms6.0 earthquakes.",
        "keywords": [
            "subarea variety",
            "local geoid",
            "seismic forecasting",
            "repeated gravity observation",
            "Qilianshan-Hexi area"
        ],
        "authors": [
            {
                "name": "Wang Shuangxu",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Xue Fuping",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Liu Liwei",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Xu Yunma",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Zhang Xi",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an "
            }
        ],
        "venue": "Journal of Geodesy and Geodynamics",
        "year": 2009
    },
    "IAh83Bbd": {
        "id": "IAh83Bbd",
        "title": "Current Vertical Deformation in the Fenwei Faultdepression Zone in Shanxi Province and Future Seismicity",
        "abstract": "In order to investigate seismicity in the peripheral areas of the Ordos block after the 2008 Wenchuan earthquake,we analyzed evolutive course of the current vertical deformation in the Fenwei fault-depression zone using fault-crossing leveling data situated on different locations.The following are obtained: \u2460 the vertical movement extent of ascending and sinking difference is about 20 mm,and there is no obvious exceptional deformation;\u2461 Small earthquake activities may be transient instability of horizontal stress field of Ordos block,due to adjustment of compressional stress from Qinghai-Tibet plate and relative strengthening of compressional stress from North China sub-plate.",
        "keywords": [
            "the 2008 Wenchuan earthquake",
            "Fault-crossing leveling",
            "Vertical deformation",
            "Seismicity"
        ],
        "authors": [
            {
                "name": "ZHANG Si-xin",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi\u2032an ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi\u2032an ,China"
            }
        ],
        "venue": "Earthquake",
        "year": 2012
    },
    "Ts7JYp9y": {
        "id": "Ts7JYp9y",
        "title": "Time evolution of fault deformation feature intensity and its relationship with strong earthquakes in Gansu and its neighborhood",
        "abstract": "Using cross-fault mobile short-leveling observational data from late 1980s to November 2009in Gansu and its neighborhood,the deformation feature intensity of related fault segments are computed,the dynamic evolution features and their relationship with the generation of earthquakes over MS5.8are studied.It is concluded that the time-curves of deformation feature intensity of all segments reflected the earthquakes over MS5.8on the faults or nearby,displaying thrust abnormity in accordance with their tectonic background from several months to about one year before the earthquakes.After these earthquakes,the abnormity disappeared,or appeared just as transitory normal abnormity(adjustment state).",
        "keywords": [
            "time-variation",
            "fault deformation feature intensity",
            "earthquake examples"
        ],
        "authors": [
            {
                "name": "Zhang Xi",
                "org": "Institute of Earthquake Prediction,CEA,Beijing ;The Second Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Xue Fuping",
                "org": "The Second Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Jia Peng",
                "org": "The Second Monitoring and Application Center,CEA,Xi'an "
            }
        ],
        "venue": "Recent Developments in World Seismology",
        "year": 2010
    },
    "O0DkuNv9": {
        "id": "O0DkuNv9",
        "title": "Time Sequence Features of Fault Deformation of Main Fractures in the Northeastern Margin of Qinghai-Tibet Block and Their Relationship with Strong Earthquakes",
        "abstract": "We study the dynamic evolution features of the tectonic deformation of main active faults in the northeastern margin of Qinghai-Tibet Block,the difference between fault segments,and their relationship with the development and occurrence of strong earthquakes,using the strain intensity ratio values calculated from mobile cross-fault short-leveling observational data from the late 1980s to the end of 2007.The results are as follows:\u2460 Nearly all strain intensity ratio-time curves of faults or segments reflect the process as\"obviously rising-rising to peak above average line-dropping\" in several months to about one year before the earthquakes with M\u22655.8 on the fault (segment) or nearby.The distinct difference of strain intensity ratio between faults or segments has certain prediction significance for the strong earthquakes in the meeting region of faults (segments) or nearby.\u2461 The northeastern margin of Qinghai-Tibet Block,especially the Qilianshan-Haiyuan fault zone and the northern margin fault of the West Qinling mountains,shows a new round of energy accumulation through the adjustment of tectonic stress field after the West Kunlun,Yumen,and Minle earthquakes.",
        "keywords": [
            "difference between fault segments",
            "cross-fault strain intensity ratio",
            "example of earthquake",
            "northeastern margin of Qinghai-Tibet Block",
            "time sequence change"
        ],
        "authors": [
            {
                "name": "ZHANG Xi",
                "org": "Institute of Earthquake Prediction,CEA,Beijing ,China"
            },
            {
                "name": "XUE Fu-ping",
                "org": "The Second Monitoring and Application Center,CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "WANG Ji-ying",
                "org": "The Second Monitoring and Application Center,CEA,Xi'an ,Shaanxi,China"
            }
        ],
        "venue": "Journal of Seismological Research",
        "year": 2009
    },
    "2iTRsqAx": {
        "id": "2iTRsqAx",
        "title": "Inversion and Analysis on the Active Characteristics of Subsections of Haiyuan Fault Belt Using GPS Data",
        "abstract": "The active characteristics of Haiyuan fault belt are analyzed using GPS data during 1999-2007 firstly.The surveying data show that the movement rates of those GPS sites become decreasing from south to north,especially the rates on two sides of the NWW and NW diration faults have big difference,and the fault movement is mainly strike-slip.Then the initial parameters of inversion are given based on the information of geology and geophysics.The slipping rates and depths of three subsections of Haiyuan fault belt are inversed with constrains of GPS profiles data.The result show that the rates from west to east are 5.49 mm/a,5.97 mm/a and 8.25 mm/a respectively and the depths are 22.8 km,13.3 km and 11.1 km respectively.Through comprehensive analysis on the GPS data and parameters of the fault it is concluded that the movement rate on Maomaoshan-Laohushan fault segment is faster than that on Haiyuan fault segment.Maomaoshan fault has big rate grads where also is earthquake vacancy(ML>6.0),so this region exists risk of strong earthquake.",
        "keywords": [
            "Slip-rate",
            "Inversion",
            "GPS data",
            "Haiyuan faults"
        ],
        "authors": [
            {
                "name": "HU Ya-xuan",
                "org": "No.2 Monitoring Center of China Earthquake Administration,Xi\u2032an,,China"
            },
            {
                "name": "CUI Du-xin",
                "org": "No.2 Monitoring Center of China Earthquake Administration,Xi\u2032an,,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "No.2 Monitoring Center of China Earthquake Administration,Xi\u2032an,,China"
            },
            {
                "name": "WANG Xiong",
                "org": "No.2 Monitoring Center of China Earthquake Administration,Xi\u2032an,,China"
            }
        ],
        "venue": "Northwestern Seismological Journal",
        "year": 2009
    },
    "lKzmpawY": {
        "id": "lKzmpawY",
        "title": "Study on the Characteristics of Strong Earthquake Deformation Anomalies and Forecasting Index in the North Segment of the South-north Seismic Belt of China",
        "abstract": "Using the regional leveling,fault-crossing short survey since 1970s,and GPS,mobile gravitation observation data since 1990s in the north segment of the south-north seismic belt of China,combining with geologic structure and recent earthquakes(MS\u22656.0) in this area,the basic characteristics of structure deformation anomalies related to strong earthquakes in the area and possible mechanism are analyzed and studied in quantitative and qualitative ways.In differ scale(kind),the strong earthquake prediction index criterions based on the structure deformation anomaly are summarized.",
        "keywords": [
            "Forecasting criterions",
            "The North segment of the south-north seismic belt of China",
            "Characteristics of deformation anomaly with strong earthquake"
        ],
        "authors": [
            {
                "name": "WANG Shuang-xu",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an ,China"
            },
            {
                "name": "ZHU Yi-qing",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an ,China"
            },
            {
                "name": "ZHANG Si-xin",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an ,China"
            },
            {
                "name": "XUE Fu-ping",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an ,China"
            }
        ],
        "venue": "Northwestern Seismological Journal",
        "year": 2012
    },
    "wOxhdV5r": {
        "id": "wOxhdV5r",
        "title": "Epicentre-source area from disturbance abnormity before Wenchuan Earthquake",
        "abstract": "We use disturbance abnormity with features of precursor wave from pointing-precursor observation of epicenter area and nearby within hundreds kilometers in Qinghai-Sichuan area before the Wenchuan Ms 8.0 earthquake on May 12, 2008 to search possible epicenter-source area. According to its abnormity vector, extent, time, space-location and the distribution characteristics of tectonic fracture, aided by construction of source-spreading function and inversion of quasi-Newton least square method. Computed epicenter-source is located on the northern segment of Longmenshan fracture, about 134 km away from real epicenter, occurred nearly 13 hours before this earthquake.",
        "keywords": [
            "Epicenter-source area",
            "Precursor wave",
            "Wenchuan Earthquake"
        ],
        "authors": [
            {
                "name": "Xi Zhang",
                "org": "Commissariat a L'Energie Atomique CEA(CEA),Gif-sur-Yvette,France"
            },
            {
                "name": "Ruisha Li",
                "org": "Commissariat a L'Energie Atomique CEA(CEA),Gif-sur-Yvette,France"
            },
            {
                "name": "Peng Jia",
                "org": "Commissariat a L'Energie Atomique CEA(CEA),Gif-sur-Yvette,France"
            },
            {
                "name": "Qingliang Wang",
                "org": "Commissariat a L'Energie Atomique CEA(CEA),Gif-sur-Yvette,France"
            }
        ],
        "venue": "Wuhan Daxue Xuebao (Xinxi Kexue Ban)/Geomatics and Information Science of Wuhan University",
        "year": 2012
    },
    "8KEciNvu": {
        "id": "8KEciNvu",
        "title": "SIMULATION AND ANALYSIS OF COSEISMIC DEFORMATION FIELD OF Ms8.1 EARTHQUAKE IN WEST TO KUNLUN MOUNTAIN PASS",
        "abstract": "The coseismic horizontal displacement field caused by the Kunlun Mountain Ms8.1 earthquake is simulated by use of elastic finite element method and GPS observations,the coseismic apparent strain variation field and the coseismic dislocation of main active faults are calculated.The results show:1)the effect of Kunlun Mountain Ms8.1 earthquake is very obvious on the west strain field of China,and a principal compressive strain area of high value has been formed near the seismogenic fault at the same time;2)the great earthquake made the east of Xinjiang area and the joint part of Xinjiang and Gansu strongly clockwise rotate,it triggered Yumen Ms5.9 and Shihezi Ms5.4 earthquakes,and made Arjin fault display strong differential motion in different segments;3)the earthquake made the movement of almost the northeastern margin of Qinghai-Tibet block,some strain energy was accumulated in Dlha's adjacent area and the east of northeastern margin of Qinghai-Tibet reversally;4)the effect of the great Kunlun Mountain earthquake is big on the joint part of Sichuan and Tibet,where some strain energy was accumulated while earthquake occurred.",
        "keywords": [
            "finite element method",
            "apparent strain variation field",
            "coseismic horizontal displacement field",
            "Qinghai-Tibet block",
            "Ms8.1 earthquake in west of Kunlun Mountain pass"
        ],
        "authors": [
            {
                "name": "Zhang Xiaoliang",
                "org": ")1)Second Crustal Monitoring and Application Center,CEA,Xi'an 2)Institute of Earthquake Science,CEA,Beijing "
            },
            {
                "name": "Jiang Zaisen",
                "org": ")1)Second Crustal Monitoring and Application Center,CEA,Xi'an 2)Institute of Earthquake Science,CEA,Beijing "
            },
            {
                "name": "Zhang Xi",
                "org": ")1)Second Crustal Monitoring and Application Center,CEA,Xi'an 2)Institute of Earthquake Science,CEA,Beijing "
            },
            {
                "name": "Zhao Yongnian",
                "org": ")1)Second Crustal Monitoring and Application Center,CEA,Xi'an 2)Institute of Earthquake Science,CEA,Beijing "
            },
            {
                "name": "Zhu Guizhi",
                "org": ")1)Second Crustal Monitoring and Application Center,CEA,Xi'an 2)Institute of Earthquake Science,CEA,Beijing "
            }
        ],
        "venue": "Journal of Geodesy and Geodynamics",
        "year": 2007
    },
    "4GwBuglS": {
        "id": "4GwBuglS",
        "title": "INVERSION FOR NEGATIVE DISLOCATION ON ELASTIC BLO-CK BOUNDARIES ALONG THE NORTHEAST MARGIN OF QINGHAI-XIZANG BLOCK AND PREDICTION FOR STRONG EARTHQUAKE LOCATION",
        "abstract": "On the basis of the velocity field results of horizontal crustal movement obtained from GPS measurements during the periods of 1993-1999, 1999-2001 and 2001-2003 in the northeast margin of Qinghai-Xizang block, and by the inversion of negative dislocation model for the elastic block boundaries, we provide in this paper a qualitative analysis and quantitative description for the difference of motion and deformation between the tectonic blocks and their boundary faults, time-space distribution of tectonic strain field, and locations with highly accumulated strain energy and correlative intensity. Furthermore, taking the regional tectonics and block strain into full consideration, we investigate the common features of background precursors relating to location prediction for M\u22656 earthquakes.",
        "keywords": [
            "inversion",
            "horizontal crustal move-ment",
            "study of earthquake examples",
            "negative dislocation model",
            "elastic block boundary"
        ],
        "authors": [
            {
                "name": "Zhang Xi",
                "org": " Second Crust Monitoring and Application Center, China Earthquake Administration , Xi'an , China Institute of Earthquake Science, China Earthquake Administration , Beijing , China Institute of Seismology, China Earthquake Administration . Wuhan , China"
            },
            {
                "name": "Jiang Zaisen",
                "org": " Second Crust Monitoring and Application Center, China Earthquake Administration , Xi'an , China Institute of Earthquake Science, China Earthquake Administration , Beijing , China Institute of Seismology, China Earthquake Administration . Wuhan , China"
            },
            {
                "name": "Wang Qi",
                "org": " Second Crust Monitoring and Application Center, China Earthquake Administration , Xi'an , China Institute of Earthquake Science, China Earthquake Administration , Beijing , China Institute of Seismology, China Earthquake Administration . Wuhan , China"
            },
            {
                "name": "Wang Shuangxu",
                "org": " Second Crust Monitoring and Application Center, China Earthquake Administration , Xi'an , China Institute of Earthquake Science, China Earthquake Administration , Beijing , China Institute of Seismology, China Earthquake Administration . Wuhan , China"
            },
            {
                "name": "Cui Duxin",
                "org": " Second Crust Monitoring and Application Center, China Earthquake Administration , Xi'an , China Institute of Earthquake Science, China Earthquake Administration , Beijing , China Institute of Seismology, China Earthquake Administration . Wuhan , China"
            },
            {
                "name": "Zhang Xiaoliang",
                "org": " Second Crust Monitoring and Application Center, China Earthquake Administration , Xi'an , China Institute of Earthquake Science, China Earthquake Administration , Beijing , China Institute of Seismology, China Earthquake Administration . Wuhan , China"
            }
        ],
        "venue": "Acta Seismologica Sinica",
        "year": 2005
    },
    "LtRKxCa4": {
        "id": "LtRKxCa4",
        "title": "RESEARCH ON PRESENT-DAY CRUSTAL MOVEMENT AND DEFORMATION IN MIDDLE OF LHASA BLOCK FROM GPS OBSERVATION",
        "abstract": "On the basis of the GPS measurement data in 2005\u20142007 along the railway in central Lhasa block,combining with the parameters of regional active faults and topographic-geomorphic character and historical strong earthquake,the characteristics of present-day crustal movement and deformation and main fault activity along the railway in the middle of Lhasa block are analyzed.The conclusions are drawn as follows.1)The present-day horizontal movement direction of the studied area is WE-NEE,consistent with the Tibetan plateau movement background by the northward collision of the India block that reflects the joint action of the horizontal dynamics from both the north-southward horizontal compression and the eastward matter flow.2)The regional apparent strain distribution manifests itself in the different mode in different zone that closely related to the crust extension deformation made and reflects the divergence of the basin extension deformation with the 'basin-mountain' tectonic activity of pressed and rise mountainous region.3)Active velocities of the faults:F76,F67 and F50 evidently descent from S to N,in the spaces that they intersect with the NE-NNE faults F73 and F65 and their adjant area of high apparent strain distribution the historical seismic activity was very strong it reflects the inherit of tectonic activity and deformation.",
        "keywords": [
            "GPS observational",
            "constitution activity difference",
            "prevent disaster meaning",
            "the middle of Lhasa block",
            "nowadays crust movement deformation"
        ],
        "authors": [
            {
                "name": "Wang Shuangxu",
                "org": ")1)Second Crust Monitoring and Application Center,CEA,Xi'an 2)Institute of Geomechanics,CAGS,Beijing "
            },
            {
                "name": "Zhang Xiaoliang",
                "org": ")1)Second Crust Monitoring and Application Center,CEA,Xi'an 2)Institute of Geomechanics,CAGS,Beijing "
            },
            {
                "name": "Zhang Xi",
                "org": ")1)Second Crust Monitoring and Application Center,CEA,Xi'an 2)Institute of Geomechanics,CAGS,Beijing "
            },
            {
                "name": "Wu Zhenhan",
                "org": ")1)Second Crust Monitoring and Application Center,CEA,Xi'an 2)Institute of Geomechanics,CAGS,Beijing "
            },
            {
                "name": "Hu Daogong",
                "org": ")1)Second Crust Monitoring and Application Center,CEA,Xi'an 2)Institute of Geomechanics,CAGS,Beijing "
            }
        ],
        "venue": "Journal of Geodesy and Geodynamics",
        "year": 2010
    },
    "AK5949mg": {
        "id": "AK5949mg",
        "title": "ANALYSIS OF STRAIN ACCUMULATION AND INFLUENCE OF GREAT EARTHQUAKE OBSERVED BY GPS IN SICHUAN AND ITS ADJACENT AREAS",
        "abstract": "Using horizontal velocity data observed by GPS in 2009-2010 in Sichuan and its nearby areas,referring to relevant results in 2004-2007 and 2007-2008,with the aid of analysis of deformation-stain field and inversion of negative dislocation,the features of recent strain accumulation of active faults and their difference between different regions and different segments and together with the evolution of influence from the Wenchuan and Yushu earthquakes are researched.The results are as follows.1)Influence from the Wechuan earthquake decreased obviously but had not ended,at the Longmenshan fault and its two ends especially.2)Weaker influence from the Yushu earthquake was observed.3)At present,these regions had background of strong earthquakes,i.s.,the southwestern margin of Ordos,boundary of Gansu-Qinghai-Sichuan and Gansu-Sichuan and Gansu-Sichuan-Shannxi,eastern boundary between Sichuan and Yunnan,from the northwestsen Yunnan to the boundary between Sichuan and Yunnan.",
        "keywords": [
            "strain field",
            "movemental velocity",
            "GPS",
            "strong earthquake",
            "negative dislocation inversion"
        ],
        "authors": [
            {
                "name": "Zhang Xi",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Jiang Fengyun",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Cui Duxin",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Zhang Xiaoliang",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an "
            },
            {
                "name": "Li Ruisha",
                "org": "Second Crust Monitoring and Application Center,CEA,Xi'an "
            }
        ],
        "venue": "Journal of Geodesy and Geodynamics",
        "year": 2011
    },
    "JJQ7CdA4": {
        "id": "JJQ7CdA4",
        "title": "Studies on surface vertical deformation of the Longmenshan and the Wenchuan M_S8.0 earthquake",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Wang Qingliang",
                "org": ""
            },
            {
                "name": "Cui Duxin",
                "org": ""
            },
            {
                "name": "Zhang Xi",
                "org": ""
            },
            {
                "name": "Wang Wenping",
                "org": ""
            },
            {
                "name": "Liu Jinwen",
                "org": ""
            }
        ],
        "venue": "Recent Developments in World Seismology",
        "year": 2010
    },
    "UbZXgHf1": {
        "id": "UbZXgHf1",
        "title": "Research on Activity Features of Xianshuihe Fault and its Relationship with Great Earthquakes Based upon Grey Relation Degree Method",
        "abstract": "Basing on mobile deformation data cross the fault and using grey relation degree analyze method,we got the new synthetic index for strike-tensile-vertical activity parameters of Xianshuihe Fault,which could reflect features,value,dynamic evolution process and tectonic deformation difference in different segment of Xianshuihe Fault.We studied the relationship of the new synthetic index with preparation-occurrence of strong earthquakes around the Xianshuihe Fault,and its relationship with preparation,co-seismic or adjustment influence of great earthquakes in large-scale area nearby.The results showed that:(1) Xianshuihe Fault mainly is left-lateral strike-slip fault.(2) The curve of activity parameters accumulation showed the anomaly variation of speeding up or turning before Xiaojin MS6.3 and Yajiang MS6.0 earthquakes.(3) We could observed the adjustment influence on the Xianshuihe Fault after the MS8.1 earthquake at the Western Pass of Kunlun Mountains,stress field intensifying or disturbing influence on Xianshuihe Fault before the Wenchuan MS8.0 earthquake,and leftlateral accelerating influence on Xianshuihe Fault after the Yushu MS7.1 earthquake in short-time.",
        "keywords": [
            "grey relation degree",
            "fault deformation",
            "analysis on great earthquakes",
            "Xianshuihe Fault"
        ],
        "authors": [
            {
                "name": "ZHANG Xi",
                "org": "The Second Monitoring and Application Center of CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "TANG Hong-tao",
                "org": "The Second Monitoring and Application Center of CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "LI Rui-sha",
                "org": "The Second Monitoring and Application Center of CEA,Xi'an ,Shaanxi,China"
            },
            {
                "name": "JIA Peng",
                "org": "The Second Monitoring and Application Center of CEA,Xi'an ,Shaanxi,China"
            }
        ],
        "venue": "Journal of Seismological Research",
        "year": 2012
    },
    "RSynbddI": {
        "id": "RSynbddI",
        "title": "Research on the Characteristics of Crustal Block Movement in Sichuan-Yunnan Area",
        "abstract": "Based on the division of Sichuan-Yunnan area,using the horizontal crustal movement velocity field by GPS measurements during 1999 to 2007 and 2009 to 2011,we calculated the state of block strain,the homogeneous elastic deformation of the internal blocks and relative motion of the boundary between the adjacent blocks by the homogeneous elastic strain block model.Considering the impact of Wenchuan MS8.0 earthquake and Yushu MS7.1 earthquake on crustal movement of Sichuan-Yunnan area,the calculation analysis results showed that:(1) The calculation results reflected the better characteristics of tectonic movement in the region;(2) The movement of the east boundary on Sichuan-yunan block mainly was strike-slip.The intersections of An'ninghe and Zemuhe Faults showed that the left-lateral strike-slip movement was blocked apparently,and there were significant strain accumulation in the block on both sides of this site,which indicated it maybe the area of possible strong earthquakes preparation in the future;(3) The spatial differences of the blocks boundary movement were enhanced in 2009~2011 than that in 2007~2009,which reflects the impact of Wenchuan MS8.0 earthquake and Yushu MS7.1 earthquake on the regional crustal movement in the whole area.",
        "keywords": [
            "homogeneous elastic strain block model",
            "crustal movement",
            "GPS",
            "Sichuan-Yunnan region"
        ],
        "authors": [
            {
                "name": "JIANG Feng-yun",
                "org": ""
            },
            {
                "name": "ZHU Liang-yu",
                "org": ""
            },
            {
                "name": "WANG Shuang-xu",
                "org": ""
            },
            {
                "name": "ZHANG Xiao-liang",
                "org": ""
            },
            {
                "name": "ZHANG Xi",
                "org": ""
            },
            {
                "name": "HUANG Zhi",
                "org": ""
            }
        ],
        "venue": "Journal of Seismological Research",
        "year": 2013
    },
    "LqYYqYy9": {
        "id": "LqYYqYy9",
        "title": "SEARCHING ON SOURCE OF ABNORMAL DISTURBANCE IN BORDER REGION OF SHAANXI AND GANSU",
        "abstract": "Abnormal disturbances like sharp pulse were obtained from vertical pendulum in Wudu\u3001Hanzhong and Ningshan station on Aug.6th,2008.According to time and space of anomalies,they build \"source precursor\" propagator to calculate possible focal region through Newton least square and grid search Method.The calculating focal region located at northern region of Longmenshan fault,is related to Pingwu\u3001Beichuan earthquake with MS5.0,54 km away and the starting time is about thirty three hours before the earthquake.",
        "keywords": [
            "Sharp pulse disturbance",
            "Source precursor signal",
            "Wenchuan aftershock"
        ],
        "authors": [
            {
                "name": "ZHANG Xi",
                "org": "No.2 Monitoring Center of China Earthquake Administration,Xi'an ,Shaanxi,China"
            },
            {
                "name": "WANG Qing-liang",
                "org": "No.2 Monitoring Center of China Earthquake Administration,Xi'an ,Shaanxi,China"
            },
            {
                "name": "JIA Peng",
                "org": "No.2 Monitoring Center of China Earthquake Administration,Xi'an ,Shaanxi,China"
            }
        ],
        "venue": "Inland Earthquake",
        "year": 2013
    },
    "iiHTDmcb": {
        "id": "iiHTDmcb",
        "title": "Characteristics of Recent Horizontal Crustal Movement and Tectonic Deformation Features in the Northwest China Region",
        "abstract": "Making use of observation data of GPS in the northwest China region and infrared distance-measuring crossing the Qilian-Longshoushan fault zone up to 2004, aided by the least square collocation and inversion of negative dislocation model for the boundaries of elastic blocks and the singular force-source, the dynamic evolution features of deformation and strain fields before and after the M _S=8.1 earthquake in the west of Kunlun Mountain Pass, especially, recent tectonic deformation and stress field status three years after this earthquake have been studied; the possible regions or segments of active blocks and their boundaries reflecting accumulation background of high strain energy of producing earthquakes over middle magnitude,have been obtained, as well as the potential epicenter. The results show that: after short-term laxation and adjustment in the northern margin of Qinghai-Xizang block after the M _S=8.1 earthquake, now the main control action of background field of northeastward pushing of the Indian plate is recovering. Moreover, the medium-segments of northern Tianshan fault zone and its meeting region with the western segment, the medium-western segments of southern Tianshan fault zone and the meeting region with Western Kunlun fault zone, medium-segment of the Aerjin fault, medium-eastern segments of the Qilianshan fault zone and its meeting region with the Haiyuan fault, the meeting region of northern margin fault of west Qinling Range and the southeastward expanding line of Zhuanglanghe fault have background of accumulation of high strain energy; Linze and Haiyuan also reflect accumulation of strain energy to some degree.",
        "keywords": [
            "Northwest China Region Horizontal deformation Negative dislocation model Seismogenic background Potential epicenter"
        ],
        "authors": [
            {
                "name": "Zhang Xi",
                "org": "Second Monitoring and Application Center, CEA, Xi\u2019an , China"
            },
            {
                "name": "Wang Shuangxu",
                "org": "Second Monitoring and Application Center, CEA, Xi\u2019an , China"
            },
            {
                "name": "Wang Wenping",
                "org": "Second Monitoring and Application Center, CEA, Xi\u2019an , China"
            },
            {
                "name": "Zhang Xiaoliang",
                "org": "Second Monitoring and Application Center, CEA, Xi\u2019an , China"
            },
            {
                "name": "Cui Duxin",
                "org": "Second Monitoring and Application Center, CEA, Xi\u2019an , China"
            },
            {
                "name": "Xue Fuping",
                "org": "Second Monitoring and Application Center, CEA, Xi\u2019an , China"
            }
        ],
        "venue": "Earthquake Research in China",
        "year": 2006
    },
    "Pk5Bm3un": {
        "id": "Pk5Bm3un",
        "title": "Molecular identification of a trichinella isolate from a naturally infected pig in Tibet, China",
        "abstract": "The first human case with trichinellosis was reported in 1964 in Tibet, China. However, up to the present, the etiological agent of trichinellosis has been unclear. The aim of this study was to identify a Tibet Trichinella isolate at a species level by PCR-based methods. Multiplex PCR revealed amplicon of the expected size (173 bp) for Trichinella spiralis in assays containing larval DNA from Tibet Trichinella isolate from a naturally infected pig. The Tibet Trichinella isolate was also identified by PCR amplification of the 5S ribosomal DNA intergenic spacer region (5S ISR) and mitochondrial large-subunit ribosomal RNA (mt-lsrDNA) gene sequences. The results showed that 2 DNA fragments (749 bp and 445 bp) of the Tibet Trichinella isolate were identical to that of the reference isolates of T. spiralis. The Tibet Trichinella isolate might be classifiable to T. spiralis. This is the first report on T. spiralis in southwestern China. \u00a9 2011, Korean Society for Parasitology.",
        "keywords": [
            "china",
            "molecular identification",
            "taxonomy",
            "tibet",
            "trichinella spiralis",
            "intergenic dna",
            "polymerase chain reaction",
            "genotypes",
            "genes"
        ],
        "authors": [
            {
                "name": "Ling Zhao Li",
                "org": "Zhengzhou University(Zhengzhou University),Zhengzhou,China"
            },
            {
                "name": "Zhong Quan Wang",
                "org": "Zhengzhou University(Zhengzhou University),Zhengzhou,China"
            },
            {
                "name": "Peng Jiang",
                "org": "Zhengzhou University(Zhengzhou University),Zhengzhou,China"
            },
            {
                "name": "Xi Zhang",
                "org": "Zhengzhou University(Zhengzhou University),Zhengzhou,China"
            },
            {
                "name": "Hui Jun Ren",
                "org": "Zhengzhou University(Zhengzhou University),Zhengzhou,China"
            },
            {
                "name": "Jing Cui",
                "org": "Zhengzhou University(Zhengzhou University),Zhengzhou,China"
            }
        ],
        "venue": "The Korean journal of parasitology",
        "year": 2011
    },
    "NFrfYh3J": {
        "id": "NFrfYh3J",
        "title": "Effects of ethanol on the viability and infectivity of Trichinella spiralis larvae",
        "abstract": "Objective To observe the effects of different concentrations(volume fraction) of ethanol solution on the infectivity of Trichinella spiralis larvae.Methods In a simulated gastric environment,100 muscle larvae of T.spiralis were treated with different volume fractions of an ethanol solution for different amounts of time and larval viability was identified by methylene blue eosin-borax(M.E.B.) staining.Sixty-four male Kunming mice were randomly divided into 8 groups(8 mice per group).Six groups of mice were orally inoculated with 500 larva or muscle containing 500 larva treated with different volume fractions of an ethanol solution for different amounts of time;the other two groups of mice were inoculated with 500 larva treated with saline as controls.Four mice from each group were sacrificed on days 7 and 42 post-infection,and the intestinal female adult worms and muscle larvae were observed.Results The mortality rate of T.spiralis muscle larvae treated with 0.20 and 0.25 of ethanol solution for 240 min was 0 and 1.4%,respectively.The time when all the larvae were respectively killed in 0.30,0.35,0.40,0.45,0.50,0.55,and 0.60 of ethanol solution was 180,90,45,30,30,20,and 20 min.The mortality rate of muscle larvae treated with 0.65 of ethanol solution for 1 and 6 min was 44.4% and 100%.The difference between the mortality rates of T.spiralis muscle larvae treated with different volume fractions of the ethanol solution for different amounts of time was statistically significant(P<0.05).Trend analysis showed that the larval mortality in 0.25-0.60 of ethanol solution increased along with an increase in ethanol concentration and prolongation of the treatment time(P<0.05).Intestinal female worms and muscle larvae were not found on days 7 and 42 after the mice were inoculated with the larvae treated with different volume fractions of the ethanol solution for different amounts of time.Conclusion Ethanol has stronger killing action on T.spiralis muscle larvae,and larvae lost their infectivity and reproductive capacity completely after they were treated with \u22650.35 of ethanol solution for 30 min.",
        "keywords": [
            "mice",
            "ethanol",
            "trichinella spiralis",
            "muscle larvae",
            "viability",
            "infectivity"
        ],
        "authors": [
            {
                "name": "zhang xi",
                "org": ""
            },
            {
                "name": "cui jing",
                "org": ""
            },
            {
                "name": "qi xin",
                "org": ""
            },
            {
                "name": "jin fengjun",
                "org": ""
            },
            {
                "name": "wang zhongquan",
                "org": ""
            }
        ],
        "venue": "Journal of Pathogen Biology",
        "year": 2009
    },
    "JbpnSkRa": {
        "id": "JbpnSkRa",
        "title": "Further study of the therapeutic effectiveness of praziquantel on mice infected with Sparganum mansoni",
        "abstract": "Objective To further study the therapeutic effectiveness of praziquantel on mice infected with Sparganum mansoni.Method Eighty mice were randomly divided into 10groups(groups 1-10,8mice each)of the same size.Each mouse was orally infected with 8spargana.Groups 1-5were treated with praziquantel(2 800mg/kg in 3doses per day for 3days)at 1,2,4,6,and 8weeks post-infection(wpi),respectively,and were then sacrificed at one week posttreatment(wpt).Groups 6-9were treated with the same dose at 1wpi and were sacrificed at 2,4,6,and 8wpt,respectively.Group 10served as a control and was not treated.After the infected mice were sacrificed,the spargana were recovered and counted,and the worm reduction rate was determined.Results The worm reduction rate in infected mice at 1,2,4,6,and 8wpi were 39%,18%,17.13%,14%,and 8.38%,respectively,at 1wpt(P<0.05),indicating that the rate tended to decrease as the start of treatment after infection was delayed(P<0.05).One wpi,the worm reduction rate in infected mice at 1,2,4,6,and 8wpt was 39%,29.63%,18.75%,14%,and 6.25%,respectively(P <0.05);the rate tended to decrease over time after treatment(P<0.05).There were no statistical differences(P> 0.05)in the worm reduction rate at the same time after infection for infected mice treated with praziquantel at 1-8wpi or infected mice at 1-8wpt.The worm reduction rate tended to decrease after a longer period post-infection.Conclusion Praziquantel appears to be therapeutically ineffective in treating sparganosis in mice.",
        "keywords": [
            "mice",
            "praziquantel",
            "treatment",
            "Sparganosis"
        ],
        "authors": [
            {
                "name": "QI Xin",
                "org": ""
            },
            {
                "name": "JIANG Peng",
                "org": ""
            },
            {
                "name": "CUI Jing",
                "org": ""
            },
            {
                "name": "TIAN Xiang-yu",
                "org": ""
            },
            {
                "name": "CHEN Meng-huan",
                "org": ""
            },
            {
                "name": "FAN Si-Yang",
                "org": ""
            },
            {
                "name": "CHEN Yu",
                "org": ""
            },
            {
                "name": "ZHANG Xi",
                "org": ""
            },
            {
                "name": "WANG Zhong-quan",
                "org": ""
            }
        ],
        "venue": "Journal of Pathogen Biology",
        "year": 2013
    },
    "JJdWZxRJ": {
        "id": "JJdWZxRJ",
        "title": "Characterization of a Trichinella spiralis 31 kDa protein and its potential application for the serodiagnosis of trichinellosis.",
        "abstract": "The Trichinella spiralis 31 kDa protein (Ts31) was screened from the excretory-secretory (ES) proteins of muscle larvae (ML) by immunoproteomics using serum from mice infected with T. spiralis at 18 days post infection (dpi). The aim of this study was to characterize the Ts31 protein and to evaluate the potential of the recombinant Ts31 protein (rTs31) for serodiagnosis of human trichinellosis. Ts31 gene was cloned and rTs31 was produced in an E. coli expression system. An anti-rTs31serum recognized the native protein migrating in a 25-55 kDa range by Western blotting of ML crude or ES antigens. Expression of Ts31 gene was observed at all developmental stages of T. spiralis (adult worms, newborn larvae, pre-encapsulated larvae and ML). An immunolocalization analysis identified Ts31 in the cuticle and stichocytes of the parasite. The sensitivity of rTs31-ELISA and ES antigen ELISA for detecting anti-Trichinella IgG antibodies in sera of patients with trichinellosis was 97.83% (45/46) and 86.78% (39/46), respectively (P>0.05); The specificity of rTs31-ELISA was 99.13% (114/115), which was significantly higher than 85.22% (98/115) of ES antigen ELISA (P<0.01). The rTs31 protein of T. spiralis could be considered as a potential diagnostic antigen for trichinellosis.",
        "keywords": [
            "Recombinant antigen",
            "Serodiagnosis",
            "Trichinella spiralis",
            "Trichinellosis"
        ],
        "authors": [
            {
                "name": "Jing Cui",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, 40 Daxue Road, Zhengzhou 450052, China."
            },
            {
                "name": "Li Wang",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, 40 Daxue Road, Zhengzhou 450052, China."
            },
            {
                "name": "Ge Ge Sun",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, 40 Daxue Road, Zhengzhou 450052, China."
            },
            {
                "name": "Li Na Liu",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, 40 Daxue Road, Zhengzhou 450052, China."
            },
            {
                "name": "Shuai Bing Zhang",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, 40 Daxue Road, Zhengzhou 450052, China."
            },
            {
                "name": "Ruo Dan Liu",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, 40 Daxue Road, Zhengzhou 450052, China."
            },
            {
                "name": "Xi Zhang",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, 40 Daxue Road, Zhengzhou 450052, China."
            },
            {
                "name": "Peng Jiang",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, 40 Daxue Road, Zhengzhou 450052, China."
            },
            {
                "name": "Zhong Quan Wang",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, 40 Daxue Road, Zhengzhou 450052, China."
            }
        ],
        "venue": "Acta tropica",
        "year": 2015
    },
    "XMDcE1OS": {
        "id": "XMDcE1OS",
        "title": "[Advances in etiology, epidemiology and genetic diversity of ].",
        "abstract": " and  are three causative agents of human thelaziasis. Most of the reported cases were caused by , occurring in the old world, particularly in Asian and European countries.  and  have rarely been reported infecting humans in North America.  has long been called the oriental eye worm, referring to its traditional distribution across eastern and southeastern Asia (i.e., China, Korea, Japan, Indonesia, Thailand, and India) where infection is endemic in animals and humans, usually in poorer rural areas and mainly among children and the elderly. The identification of the parasite was mainly based on the characteristics of oral and genital organs. In Asia and Europe, vectors for this nematode are male  and  drosophilids respectively, which feed on ocular secretions of hosts and transmit infective stage larvae to domestic and wild carnivores, lagomorphs, and humans. China probably has the largest number of cases with thelaziasis in the world, and lots of cases have been existed in other Asian countries such as Japan and Korea. Although a few of human cases have been reported, there were high infection rates of wild animals and domesticated dogs and cats in most of European countries. Based on the 1 gene, a total of 21 haplotypes were identified in the samples from worldwide, in which, one circulated only in European countries (h1), while the other 20 haplotypes were distributed in Korea, Japan and China. In general, the Chinese clinical isolates of  expressed high genetic diversity. The population differences between Europe and Asian countries were greater than those among China, Korea and Japan. The  populations from Europe and Asia should be divided into two separate sub-populations. These two groups started to diverge during the middle Pleistocene.",
        "keywords": [
            "Epidemiology",
            "Etiology",
            "Genetic diversity",
            "Thelazia",
            "Thelazia callipaeda",
            "Thelaziasis"
        ],
        "authors": [
            {
                "name": "Zhang Xi",
                "org": "Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450052, China."
            },
            {
                "name": "Jiang Peng",
                "org": "Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450052, China."
            },
            {
                "name": "Liu Ruo-Dan",
                "org": "Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450052, China."
            },
            {
                "name": "Long Shao-Rong",
                "org": "Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450052, China."
            },
            {
                "name": "Cui Jing",
                "org": "Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450052, China."
            },
            {
                "name": "Wang Zhong-Quan",
                "org": "Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450052, China."
            }
        ],
        "venue": "Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control",
        "year": 2019
    },
    "6R3F9vs5": {
        "id": "6R3F9vs5",
        "title": "The phylogenetic diversity of Spirometra erinaceieuropaei isolates from southwest Chinarevealed by multi genes.",
        "abstract": "The larval plerocercoid of Spirometra erinaceieuropaei can parasitize humans, causing a serious food borne parasitic zoonosis known as sparganosis. Sparganosis have increased in China in recent years. In this study, the prevalence of sparganum infection in wild frogs in 9 geographical areas in southwest China was firstly investigated. Of 276 caught frogs, 55 frogs were found to be infected with sparganum. Then, the population genetic structure of these sparganum isolates was explored based on four molecular markers (cytb, cox1, rrnS and 28S rDNA D1). Highly genetic diversity and the genetic differentiation among sparganum isolates from different sites were revealed in the DNA polymorphism analyses. Both the phylogenetic inference and the analysis of the median-joining network supported two clades in the southwest S. erinaceieuropaei population. However, none demographic population expansion of the southwest S. erinaceieuropaei population was observed in the neutrality test, mismatch distribution analysis and Bayesian skyline plot analysis. Finally, the phylogenetic diversity of S. erinaceieuropaei from eastern, central, southern and southwest China was analyzed, the result suggested that Chinese S. erinaceieuropaei population should be divided into two groups (Group I and Group II), and they started to divergence in the middle Pliocene.",
        "keywords": [
            "Genetic structure",
            "Infection",
            "Southwest China",
            "Sparganum",
            "Spirometra erinaceieuropaei"
        ],
        "authors": [
            {
                "name": "Xi Zhang",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou 450052, China."
            },
            {
                "name": "Han Wang",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou 450052, China."
            },
            {
                "name": "Jing Cui",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou 450052, China."
            },
            {
                "name": "Peng Jiang",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou 450052, China."
            },
            {
                "name": "Mei Long Lin",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou 450052, China."
            },
            {
                "name": "Yun Lu Zhang",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou 450052, China."
            },
            {
                "name": "Ruo Dan Liu",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou 450052, China."
            },
            {
                "name": "Zhong Quan Wang",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou 450052, China."
            }
        ],
        "venue": "Acta tropica",
        "year": 2016
    },
    "VdowyEVz": {
        "id": "VdowyEVz",
        "title": "Genetic variation and phylogenetic relationship of Trichinella isolates in China",
        "abstract": "Genetic variation and phylogenetic relationship of Trichinella isolates in China were studied by analysis of mitochondrial cytochrome coxidase gene(COI) and mitochondrial small subunit ribosomal DNA(mtSSU) as molecular markers.The DNA fragments from the 7 Trichinella isolates from China were amplified by PCR-based methods.The genetic distances and sequence similarity were compared with the corresponding sequences of T.spiralis in GenBank by using the DNAMAN software.The phylogenetic trees were constructed by MEGA 4.0 with Neighbor-joining method.The results showed that the DNA fragments with 649bp(mtSSU)and 419bp(CO\u0399) from the 7 isolates were amplified,and some different with that of T.spiralis in GenBank.The mtSSU gene had four variable sites(248,293,537,and 539),COI gene had only two variable site(273 and 382),and all the type of genetic variations were conversion of C-T or T-C.Based on the phylogenetic tree,Nanyang and Yunnan isolates were close,while the phylogenetic relationship of Tibet,Xi'an and Guangxi isolates were closer.The results demonstrated that the genetic variation of the 7 T.spiralis isolates from China was small and their phylogenetic relationship was close.",
        "keywords": [
            "Trichinella spiralis",
            "mtSSU",
            "genetic variation",
            "CO\u0399",
            "phylogenetic relationship"
        ],
        "authors": [
            {
                "name": "LIU Li-na",
                "org": "Department of Parasitology,Medical College,Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "CUI Jing",
                "org": "Department of Parasitology,Medical College,Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "JIANG Peng",
                "org": "Department of Parasitology,Medical College,Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "WANG Lei",
                "org": "Department of Parasitology,Medical College,Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "LI Ling-zhao",
                "org": "Department of Parasitology,Medical College,Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "ZHANG Xi",
                "org": "Department of Parasitology,Medical College,Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "WANG Zhong-quan",
                "org": "Department of Parasitology,Medical College,Zhengzhou University,Zhengzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Zoonoses",
        "year": 2011
    },
    "WUAieWrD": {
        "id": "WUAieWrD",
        "title": "The optimized protocol of artificial digestion method for inspection of Trichinella spiralis in meat",
        "abstract": "To identify the major factors affecting the artificial digestion method for detection of Trichinella spiralis in meat and to optimize the method for increased sensitivity, groups of mice were orally inoculated with T.spiralis muscle larvae at various dosages, and were slaughtered at 42 days post-infection. Larvae were collected from the mouse muscles using the method recommended by International Commission on Trichinellosis (ICT-digestion). Different settling vessels, temperatures, sieves and digestion time were examined for effect on the recovery of T. spiralis larvae from muscle tissue. The larval recovery rate by conical cylinders was significantly higher than separatory funnels (t=33.090, p<0.05), and optomal larval recovery was obtained with #40 (425 \u03bcm mesh) sieve at a reduced temperature (43 \u2103, p<0.01). Higher larval recovery rate was obtained with a longer digestion time (2 h). The improved digestion protocol was applied to test the meat samples containing 0.1 or 1 lpg and showed 100 % larval recovery.",
        "keywords": [
            "affecting factores",
            "trichinella spiralis",
            "optimized protocol",
            "artificial digestion method",
            "meat inspection",
            "sieves",
            "larvae",
            "analytical methods",
            "food quality",
            "methodology",
            "food safety",
            "temperature"
        ],
        "authors": [
            {
                "name": "LI Feng",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou , China"
            },
            {
                "name": "WANG Zhong-quan",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou , China"
            },
            {
                "name": "CUI Jing",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou , China"
            },
            {
                "name": "LI Nan",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou , China"
            },
            {
                "name": "JIANG Peng",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou , China"
            },
            {
                "name": "WANG Li",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou , China"
            },
            {
                "name": "ZHANG Xi",
                "org": "Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou , China"
            }
        ],
        "venue": "Chinese Journal of Preventive Veterinary Medicine",
        "year": 2009
    },
    "sX90lrEa": {
        "id": "sX90lrEa",
        "title": "Inspection methods for the pre-encapsulated larvae of Trichinella spiralis in meat and the influencing factors",
        "abstract": "To observe the efficiency of artificial digestion method and Baermann's technique for inspection of the pre-encapsulated larvae(PEL)of Trichinella spiralis in meat and the influencing factors,45 male Kunming mice were randomly divided into 3 groups(15 mice per group).Each group of mice was orally inoculated with 20,10 or 5 muscle larvae of T.spiralis,respectively.All infected mice were slaughtered at 18 days post-infection and the muscles were cut into pieces.The digestion method recommended by International Commission on Trichinellosis(ICT-digestion),the Chinese criterion \"diagnostic techniques for Trichinella spiralis in swine\"(GB/T18642-2002)(GB-digestion)and Baermann's technique were used to inspect the PEL in the infected muscle.It was found that the detection rate of PEL in muscle of mice infected with 20 muscle larvae by ICT-digestion,GB-digestion method and Baermann's technique were all 100%(15/15)(\u03c7220=0.000,P>0.05);and those of PEL in muscle of mice infected with 10 larvae by the above-mentioned three methods were 93.33%(14/15),93.33%(14/15)and 100%(15/15),respectively(\u03c7210=1.645,P>0.05).When the three methods were applied to examine muscle from mice infected with 5 larvae,the detection rate of PEL were 63.33%(19/30),90%(27/30)and 100%(30/30),respectively(\u03c725=18.866,P<0.05).When muscle of mice slaughtered at 18 days post-infection was digested for 1h,2h,3h,4h and 5h,the death rate of PEL was 8.49%(53/624),29.77%(181/608),58.46%(449/768),67.83%(407/600)and 84.70%(515/608),respectively.The mortality was increased along with the prolongation of digestion time(\u03c72=920.772,P<0.05).It is evident that Baermann's technique is superior to the digestion method for inspection of T.spiralis pre-encapsulated larvae in meat.",
        "keywords": [
            "trichinella spiralis",
            "baermann's technique",
            "digestion method",
            "pre-encapsulated larvae(pel)",
            "meat inspection",
            "diagnosis",
            "helminths"
        ],
        "authors": [
            {
                "name": "JIANG Peng",
                "org": "Department of Parasitology,Medical College,Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "WANG Zhong-quan",
                "org": "Department of Parasitology,Medical College,Zhengzhou