{
    "kftBkczI": {
        "id": "kftBkczI",
        "title": "Alpha1-antitrypsin and neutrophil elastase imbalance and lung cancer risk.",
        "abstract": "Imbalance between alpha(1)-antitrypsin and neutrophil elastase is an underlying cause of lung tissue damage that may create a favorable host environment for carcinogenesis. We conducted a case-control study to investigate whether genetic variations indicative of alpha(1)-antitrypsin deficiency (A1ATD) or an excess of neutrophil elastase modify lung cancer riskThe case patients were 305 consecutively identified primary lung cancer patients, and the control subjects were 338 community residents. Protease inhibitor-1 (PI1), encoding alpha(1)-antitrypsin, was typed by an isoelectric focusing assay. Neutrophil elastase-2 (ELA2), encoding neutrophil elastase, was typed by two single-nucleotide polymorphism sites. Multivariable logistic regression models tested the independent and interactive effects of PI1, ELA2, tobacco smoke exposure, COPD, and family history of lung cancerSex and ethnicity were comparable between case patients and control subjects, but case patients were more likely to be smokers, and to have a history of COPD, environmental tobacco smoke exposure, and a positive family history of lung cancer. Haplotype analysis indicated an overall strong association between the two ELA2 markers and lung cancer risk. Our best-fitting model showed significant and independent effects of the PI1-deficient allele (odds ratio [OR], 2.0; 95% confidence interval [CI], 1.4 to 3.0) and the ELA2 T-G haplotype (OR, 4.1; 95% CI, 1.9 to 8.9) on lung cancer risk, and an increased risk (OR, 2.6; 95% CI, 2.4 to 2.8) for individuals carrying both a PI1-deficient allele and a G-G haplotypeGenotypes indicative of A1ATD and/or an excess of neutrophil elastase are significantly associated with lung cancer risk. Our findings may provide opportunities to better understand the mechanisms of lung cancer development and risk reduction.",
        "keywords": [],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA. yang.ping@mayo.edu"
            },
            {
                "name": "William R Bamlet",
                "org": ""
            },
            {
                "name": "Zhifu Sun",
                "org": ""
            },
            {
                "name": "Jon O Ebbert",
                "org": ""
            },
            {
                "name": "Marie-Christine Aubry",
                "org": ""
            },
            {
                "name": "Michael J Krowka",
                "org": ""
            },
            {
                "name": "William R Taylor",
                "org": ""
            },
            {
                "name": "Randolph S Marks",
                "org": ""
            },
            {
                "name": "Claude Deschamps",
                "org": ""
            },
            {
                "name": "Stephen J Swensen",
                "org": ""
            },
            {
                "name": "Eric D Wieben",
                "org": ""
            },
            {
                "name": "Julie M Cunningham",
                "org": ""
            },
            {
                "name": "Lee Joseph Melton",
                "org": ""
            },
            {
                "name": "Mariza de Andrade",
                "org": ""
            }
        ],
        "venue": "Chest",
        "year": 2005
    },
    "6ijupIGj": {
        "id": "6ijupIGj",
        "title": "Candidate pathway-based genetic association study of platinum and platinum-taxane related toxicity in a cohort of primary lung cancer patients.",
        "abstract": "Chemotherapy-induced peripheral neuropathy (CIPN) is a common toxicity secondary to chemotherapy. Genetic factors may be important in predisposing patients to this adverse effect.We studied 950 primary lung cancer patients, who received platinum or platinum-combination drug chemotherapy and who had DNA available for study. We analyzed epidemiological risk factors in 279 CIPN patients and 456 non-CIPN patients and genetic risk factors in 141 CIPN patients and 259 non-CIPN patients. The risk factors studied included demographic, diagnostic, and treatment data, as well as 174 tag SNPs (single nucleotide polymorphisms) across 43 candidate genes in the glutathione, cell cycle, DNA repair, cell signaling, and apoptosis pathways.Patients who had diabetes mellitus were more likely to have CIPN (p=0.0002). Other epidemiologic risk factors associated with CIPN included number of cycles (p=0.0004) and type of concurrent chemotherapy (p<0.001). SNPs most associated with CIPN were in glutathione peroxidase 7 (GPX7) gene (p values 0.0015 and 0.0028, unadjusted and adjusted) and in ATP-binding cassette sub-family C member 4 (ABCC4) gene (p values 0.037 and 0.006, unadjusted and adjusted). We also found other suggestive associations in methyl-o-guanine-methyl-transferase (MGMT) and glutathione-S-transferase (GST) isoforms.Epidemiological and genetic risk factors associated with CIPN in this cohort, included the type of chemotherapy drug, intensity of chemotherapy treatment, and genes known to be associated with chemotherapy resistance. These findings suggest that differentiating between cytotoxic and neurotoxic mechanisms of chemotherapy drugs is challenging but represents an important step toward individualized therapy and improving quality of life for patients.",
        "keywords": [
            "chemotherapy induced peripheral neuropathy",
            "diabetes",
            "genetic",
            "paclitaxel",
            "platinum drugs",
            "single nucleotide polymorphism"
        ],
        "authors": [
            {
                "name": "Cassandra Johnson",
                "org": "Departments of Neurology, Oncology, Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, MN, USA."
            },
            {
                "name": "Vernon S Pankratz",
                "org": "Departments of Neurology, Oncology, Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, MN, USA."
            },
            {
                "name": "Ana I Velazquez",
                "org": "Departments of Neurology, Oncology, Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, MN, USA."
            },
            {
                "name": "Jeremiah A Aakre",
                "org": "Departments of Neurology, Oncology, Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, MN, USA."
            },
            {
                "name": "Charles L Loprinzi",
                "org": "Departments of Neurology, Oncology, Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, MN, USA."
            },
            {
                "name": "Nathan P Staff",
                "org": "Departments of Neurology, Oncology, Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, MN, USA."
            },
            {
                "name": "Anthony J Windebank",
                "org": "Departments of Neurology, Oncology, Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, MN, USA."
            },
            {
                "name": "Ping Yang",
                "org": "Departments of Neurology, Oncology, Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, MN, USA."
            }
        ],
        "venue": "Journal of the neurological sciences",
        "year": 2015
    },
    "XX5cLwmV": {
        "id": "XX5cLwmV",
        "title": "Worse disease-free survival in never-smokers with ALK+ lung adenocarcinoma.",
        "abstract": "The EML4-anaplastic lymphoma kinase (ALK) translocation is a recognized oncogenic driver in non-small cell lung cancer. We investigated immunohistochemistry (IHC) screening with fluorescence in situ hybridization (FISH) confirmation for ALK detection and estimated the prevalence of ALK positivity in our patient cohort of never-smokers, together with differences in clinical outcomes and prognostic factors for patients with ALK-positive and ALK-negative tumors.We designed a three-phase study (training, validation, and testing) in 300 never-smokers with lung adenocarcinoma from the observational Mayo Clinic Lung Cancer Cohort. Tumor samples were tested using IHC and FISH, and concordance between the methods was assessed. Clinical outcomes were assessed via 5-year progression- or recurrence-free survival from diagnosis. Prognostic factors for ALK-positive tumors and metastases were also investigated.ALK-positive patients were significantly (p < 0.05) younger and had higher grade tumors than ALK-negative patients. ALK positivity was 12.2% by IHC and confirmed at 8.2% of tumors by FISH, with complete concordance between IHC 3+/0 and FISH+/- assessments, respectively. Five-year risk of progression or recurrence was doubled for patients with ALK-positive compared with ALK-negative tumors; ALK-positive tumors also appeared to be associated with a higher risk of brain and liver metastases.Our findings suggest that ALK positivity is associated with a significantly poor outcome in nonsmoking-related adenocarcinoma and that ALK-positive tumors may be associated with an increased risk of brain and liver metastases compared with ALK-negative disease. Consequently, an unmet medical need exists in ALK-positive lung cancer patients, and effective ALK-specific therapies are needed.",
        "keywords": [],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "Division of Epidemiology, Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA. yang.ping@mayo.edu"
            },
            {
                "name": "Kimary Kulig",
                "org": ""
            },
            {
                "name": "Jennifer M Boland",
                "org": ""
            },
            {
                "name": "Michele R Erickson-Johnson",
                "org": ""
            },
            {
                "name": "Andre M Oliveira",
                "org": ""
            },
            {
                "name": "Jason Wampfler",
                "org": ""
            },
            {
                "name": "Aminah Jatoi",
                "org": ""
            },
            {
                "name": "Claude Deschamps",
                "org": ""
            },
            {
                "name": "Randolph Marks",
                "org": ""
            },
            {
                "name": "Connie Fortner",
                "org": ""
            },
            {
                "name": "Shawn Stoddard",
                "org": ""
            },
            {
                "name": "Francis Nichols",
                "org": ""
            },
            {
                "name": "Julian Molina",
                "org": ""
            },
            {
                "name": "Marie-Christine Aubry",
                "org": ""
            },
            {
                "name": "Hui Tang",
                "org": ""
            },
            {
                "name": "Eunhee S Yi",
                "org": ""
            }
        ],
        "venue": "Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer",
        "year": 2012
    },
    "OC0sxG2q": {
        "id": "OC0sxG2q",
        "title": "Genomic rearrangements define lineage relationships between adjacent lepidic and invasive components in lung adenocarcinoma.",
        "abstract": "The development of adenocarcinoma of the lung is believed to proceed from in situ disease (adenocarcinoma in situ, AIS) to minimally invasive disease with prominent lepidic growth (minimally invasive adenocarcinoma, MIA), then to fully invasive adenocarcinoma (AD), but direct evidence for this model has been lacking. Because some lung adenocarcinomas show prominent lepidic growth (AD-L), we designed a study to address the lineage relationship between the lepidic (noninvasive) component (L) and the adjacent nonlepidic growth component representing invasive disease within individual tumors. Lineage relationships were evaluated by next-generation DNA sequencing to define large genomic rearrangements in microdissected tissue specimens collected by laser capture. We found a strong lineage relationship between the majority of adjacent lepidic and invasive components, supporting a putative AIS-AD transition. Notably, many rearrangements were detected in the less aggressive lepidic component, although the invasive component exhibited an overall higher rate of genomic rearrangement. Furthermore, a significant number of genomic rearrangements were present in histologically normal lung adjacent to tumor, but not in host germline DNA, suggesting field defects restricted to zonal regions near a tumor. Our results offer a perspective on the genetic pathogenesis underlying adenocarcinoma development and its clinical management.",
        "keywords": [],
        "authors": [
            {
                "name": "Stephen J Murphy",
                "org": "Authors' Affiliations: Departments of Molecular Medicine, General Thoracic Surgery, Pulmonary and Critical Care Medicine, Health Sciences Research, and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota."
            },
            {
                "name": "Dennis A Wigle",
                "org": "Authors' Affiliations: Departments of Molecular Medicine, General Thoracic Surgery, Pulmonary and Critical Care Medicine, Health Sciences Research, and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota."
            },
            {
                "name": "Joema Felipe Lima",
                "org": "Authors' Affiliations: Departments of Molecular Medicine, General Thoracic Surgery, Pulmonary and Critical Care Medicine, Health Sciences Research, and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota."
            },
            {
                "name": "Faye R Harris",
                "org": "Authors' Affiliations: Departments of Molecular Medicine, General Thoracic Surgery, Pulmonary and Critical Care Medicine, Health Sciences Research, and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota."
            },
            {
                "name": "Sarah H Johnson",
                "org": "Authors' Affiliations: Departments of Molecular Medicine, General Thoracic Surgery, Pulmonary and Critical Care Medicine, Health Sciences Research, and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota."
            },
            {
                "name": "Geoffrey Halling",
                "org": "Authors' Affiliations: Departments of Molecular Medicine, General Thoracic Surgery, Pulmonary and Critical Care Medicine, Health Sciences Research, and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota."
            },
            {
                "name": "Michael K Asiedu",
                "org": "Authors' Affiliations: Departments of Molecular Medicine, General Thoracic Surgery, Pulmonary and Critical Care Medicine, Health Sciences Research, and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota."
            },
            {
                "name": "Charlie T Seto",
                "org": "Authors' Affiliations: Departments of Molecular Medicine, General Thoracic Surgery, Pulmonary and Critical Care Medicine, Health Sciences Research, and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota."
            },
            {
                "name": "Simone Terra",
                "org": "Authors' Affiliations: Departments of Molecular Medicine, General Thoracic Surgery, Pulmonary and Critical Care Medicine, Health Sciences Research, and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota."
            },
            {
                "name": "Farhad Kosari",
                "org": "Authors' Affiliations: Departments of Molecular Medicine, General Thoracic Surgery, Pulmonary and Critical Care Medicine, Health Sciences Research, and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota."
            },
            {
                "name": "Tobias Peikert",
                "org": "Authors' Affiliations: Departments of Molecular Medicine, General Thoracic Surgery, Pulmonary and Critical Care Medicine, Health Sciences Research, and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota."
            },
            {
                "name": "Ping Yang",
                "org": "Authors' Affiliations: Departments of Molecular Medicine, General Thoracic Surgery, Pulmonary and Critical Care Medicine, Health Sciences Research, and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MinnesotaAuthors' Affiliations: Departments of Molecular Medicine, General Thoracic Surgery, Pulmonary and Critical Care Medicine, Health Sciences Research, and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota."
            },
            {
                "name": "Marie-Christine Aubry",
                "org": "Authors' Affiliations: Departments of Molecular Medicine, General Thoracic Surgery, Pulmonary and Critical Care Medicine, Health Sciences Research, and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota vasmatzis.george@mayo.edu aubry.mariechristine@mayo.edu."
            },
            {
                "name": "George Vasmatzis",
                "org": "Authors' Affiliations: Departments of Molecular Medicine, General Thoracic Surgery, Pulmonary and Critical Care Medicine, Health Sciences Research, and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota vasmatzis.george@mayo.edu aubry.mariechristine@mayo.edu."
            }
        ],
        "venue": "Cancer research",
        "year": 2014
    },
    "yWNus13Q": {
        "id": "yWNus13Q",
        "title": "A DRD1 polymorphism predisposes to lung cancer among those exposed to secondhand smoke during childhood.",
        "abstract": "Lung cancer has a familial component which suggests a genetic contribution to its etiology. Given the strong evidence linking smoking with lung cancer, we studied miRNA-related loci in genes associated with smoking behavior. CHRNA, CHRNB gene families, CYP2A6, and DRD1 (dopamine receptor D1) were mined for SNPs that fell within the seed region of miRNA binding sites and then tested for associations with risk in a three-stage validation approach. A 3'UTR (untranslated region) SNP in DRD1 was associated with a lower risk of lung cancer among individuals exposed to secondhand smoke during childhood [OR, 0.69; 95% confidence interval (CI), 0.60-0.79; P < 0.0001]. This relationship was evident in both ever (OR, 0.74; 95% CI, 0.62-0.88; P = 0.001) and never smokers (OR, 0.61; 95% CI, 0.47-0.79; P < 0.0001), European American (OR, 0.65; 95% CI, 0.53-0.80; P < 0.0001), and African American (OR, 0.73; 95% CI, 0.62-0.88; P = 0.001) populations. Although much remains undefined about the long-term risks associated with exposure to secondhand smoke and heterogeneity between individuals in regard to their susceptibility to the effects of secondhand smoke, our data show an interaction between an SNP in the 3'UTR of DRD1 and exposure to secondhand smoke during childhood. Further work is needed to explore the mechanistic underpinnings of this SNP and the nature of the interaction between DRD1 and exposure to secondhand smoke during childhood.",
        "keywords": [],
        "authors": [
            {
                "name": "Ana I Robles",
                "org": "Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland."
            },
            {
                "name": "Ping Yang",
                "org": "Mayo Clinic, Department of Health Sciences Research, Rochester, Minnesota."
            },
            {
                "name": "Jin Jen",
                "org": "Department of Laboratory Medicine and Pathology and Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota."
            },
            {
                "name": "Andrew C McClary",
                "org": "Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland. Department of Pathology, Stanford University Hospital and Clinics, Stanford, California."
            },
            {
                "name": "Kara Calhoun",
                "org": "Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland."
            },
            {
                "name": "Elise D Bowman",
                "org": "Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland."
            },
            {
                "name": "Kirsi V\u00e4h\u00e4kangas",
                "org": "School of Pharmacy/Toxicology, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland."
            },
            {
                "name": "K Leigh Greathouse",
                "org": "Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland."
            },
            {
                "name": "Yi Wang",
                "org": "Division of Preventive Medicine, School of Environmental Science and Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China. Division of Epidemiology, Health Sciences Research, Mayo Clinic, Rochester, Minnesota."
            },
            {
                "name": "Susan Olivo-Marston",
                "org": "Division of Epidemiology, College of Public Health, Ohio State University, Columbus, Ohio."
            },
            {
                "name": "Angela S Wenzlaff",
                "org": "Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan."
            },
            {
                "name": "Bo Deng",
                "org": "Division of Epidemiology, Health Sciences Research, Mayo Clinic, Rochester, Minnesota. Thoracic Surgery Department, Institute of Surgery Research, Daping Hospital, The Third Military Medical University, Chongqing, China."
            },
            {
                "name": "Ann G Schwartz",
                "org": "Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan."
            },
            {
                "name": "Br\u00edd M Ryan",
                "org": "Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland. ryanb@mail.nih.gov."
            }
        ],
        "venue": "Cancer prevention research (Philadelphia, Pa.)",
        "year": 2014
    },
    "r2LcfPgf": {
        "id": "r2LcfPgf",
        "title": "Epidemiology of lung cancer prognosis: quantity and quality of life.",
        "abstract": "Primary lung cancer is very heterogeneous in its clinical presentation, histopathology, and treatment response; and like other diseases, the prognosis consists of two essential facets: survival and quality of life (QOL). Lung cancer survival is mostly determined by disease stage and treatment modality, and the 5-Year survival rate has been in a plateau of 15% for three decades. QOL is focused on life aspects that are affected by health conditions and medical interventions; the balance of physical functioning and suffering from treatment side effects has long been a concern of care providers as well as patients. Obviously needed are easily measurable biologic markers to stratify patients before treatment for optimal results in survival and QOL and to monitor treatment responses and toxicities. Targeted therapies toward the mechanisms of tumor development, growth, and metastasis are promising and actively translated into clinical practice. Long-term lung cancer (LTLC) survivors are people who are alive 5 Years after the diagnosis. Knowledge about the health and QOL in LTLC survivors is limited because outcome research in lung cancer has been focused mainly on short-term survival. The independent or combined effects of lung cancer treatment, aging, smoking and drinking, comorbid conditions, and psychosocial factors likely cause late effects, including organ malfunction, chronic fatigue, pain, or premature death among lung cancer survivors. New knowledge to be gained should help lung cancer survivors, their healthcare providers, and their caregivers by providing evidence for establishing clinical recommendations to enhance their long-term survival and health-related QOL.",
        "keywords": [
            "health care",
            "quality of life",
            "epidemiology"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "Mayo Clinic, College of Medicine, Rochester, MN, USA."
            }
        ],
        "venue": "Methods in molecular biology (Clifton, N.J.)",
        "year": 2009
    },
    "QsxzvDlm": {
        "id": "QsxzvDlm",
        "title": "DNA methylation and RNA expression profiles in lung adenocarcinomas of never-smokers.",
        "abstract": "Lung cancer occurs in never-smokers. Epigenetic changes in lung cancer potentially represent important diagnostic, prognostic, and therapeutic targets. We compared DNA methylation profiles of 28 adenocarcinomas of the lungs of never-smokers with paired adjacent nonmalignant lung tissue. We correlated differential methylation changes with gene expression changes from the same 28 sample pairs. Using principal component analysis, we observed a distinct separation in methylation profiles between tumor and adjacent nonmalignant lung tissue. Tumors were generally hypomethylated compared with adjacent nonmalignant tissue. Of 1,906 CpG sites differentially methylated between tumor and nonmalignant tissue, 1,198 were within classically defined CpG islands where tumors were hypermethylated compared with nonmalignant tissue. A total of 708 sites were outside CpG islands where tumors were hypomethylated compared with nonmalignant tissue. There were significant differences in expression of 351 genes (23%) of the 1,522 genes matched to the differentially methylated CpG sites. Genes that were not significantly differentially expressed and were hypermethylated within CpG sites were enriched for homeobox genes. These results suggest that the methylation profiles of lung adenocarcinomas of never-smokers and adjacent nonmalignant lung tissue are significantly different. Despite the differential methylation of homeobox genes, no significant changes in expression of these genes were detected.",
        "keywords": [
            "cell cycle",
            "dna methylation",
            "epigenetics",
            "gene expression",
            "homeobox",
            "lung adenocarcinoma"
        ],
        "authors": [
            {
                "name": "Aaron S Mansfield",
                "org": "Division of Medical Oncology, Department of Oncology, Mayo Clinic, Rochester, MN, USA."
            },
            {
                "name": "Liang Wang",
                "org": "Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA."
            },
            {
                "name": "Julie M Cunningham",
                "org": "Division of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA; Medical Genome Facility, Mayo Clinic, Rochester, MN, USA."
            },
            {
                "name": "Jin Jen",
                "org": "Division of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA; Medical Genome Facility, Mayo Clinic, Rochester, MN, USA; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA."
            },
            {
                "name": "Christopher P Kolbert",
                "org": "Medical Genome Facility, Mayo Clinic, Rochester, MN, USA."
            },
            {
                "name": "Zhifu Sun",
                "org": "Division of Biomedical Statistics and Informatics, Health Sciences Research, Mayo Clinic, Rochester, MN, USA."
            },
            {
                "name": "Ping Yang",
                "org": "Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA; Division of Epidemiology and Department of Medical Genetics, Health Sciences Research, Mayo Clinic, Rochester, MN, USA. "
            }
        ],
        "venue": "Cancer genetics",
        "year": 2014
    },
    "FuzAguuU": {
        "id": "FuzAguuU",
        "title": "A recurrent mutation in PARK2 is associated with familial lung cancer.",
        "abstract": "PARK2, a gene associated with Parkinson disease, is a tumor suppressor in human malignancies. Here, we show that c.823C>T (p.Arg275Trp), a germline mutation in PARK2, is present in a family with eight cases of lung cancer. The resulting amino acid change, p.Arg275Trp, is located in the highly conserved RING finger 1 domain of PARK2, which encodes an E3 ubiquitin ligase. Upon further analysis, the c.823C>T mutation was detected in three additional families affected by lung cancer. The effect size for PARK2 c.823C>T (odds ratio = 5.24) in white individuals was larger than those reported for variants from lung cancer genome-wide association studies. These data implicate this PARK2 germline mutation as a genetic susceptibility factor for lung cancer. Our results provide a rationale for further investigations of this specific mutation and gene for evaluation of the possibility of developing targeted therapies against lung cancer in individuals with PARK2 variants by compensating for the loss-of-function effect caused by the associated variation.",
        "keywords": [],
        "authors": [
            {
                "name": "Donghai Xiong",
                "org": "Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA; Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA."
            },
            {
                "name": "Yian Wang",
                "org": "Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA; Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA."
            },
            {
                "name": "Elena Kupert",
                "org": "Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA; Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA."
            },
            {
                "name": "Claire Simpson",
                "org": "Computational and Statistical Genomics Branch, National Human Genome Research Institute, NIH, Baltimore, MD 20892, USA."
            },
            {
                "name": "Susan M Pinney",
                "org": "Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA."
            },
            {
                "name": "Colette R Gaba",
                "org": "College of Medicine, University of Toledo, Toledo, OH 43614, USA."
            },
            {
                "name": "Diptasri Mandal",
                "org": "Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA."
            },
            {
                "name": "Ann G Schwartz",
                "org": "Karmanos Cancer Institute, Detroit, MI 48201, USA."
            },
            {
                "name": "Ping Yang",
                "org": "Mayo Clinic, Rochester, MN 55905, USA."
            },
            {
                "name": "Mariza de Andrade",
                "org": "Mayo Clinic, Rochester, MN 55905, USA."
            },
            {
                "name": "Claudio Pikielny",
                "org": "Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Lebanon, NH 03755, USA."
            },
            {
                "name": "Jinyoung Byun",
                "org": "Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Lebanon, NH 03755, USA."
            },
            {
                "name": "Yafang Li",
                "org": "Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Lebanon, NH 03755, USA."
            },
            {
                "name": "Dwight Stambolian",
                "org": "Department of Ophthalmology and Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA."
            },
            {
                "name": "Margaret R Spitz",
                "org": "Baylor College of Medicine, Houston, TX 77030, USA."
            },
            {
                "name": "Yanhong Liu",
                "org": "Baylor College of Medicine, Houston, TX 77030, USA."
            },
            {
                "name": "Christopher I Amos",
                "org": "Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Lebanon, NH 03755, USA."
            },
            {
                "name": "Joan E Bailey-Wilson",
                "org": "Computational and Statistical Genomics Branch, National Human Genome Research Institute, NIH, Baltimore, MD 20892, USA."
            },
            {
                "name": "Marshall Anderson",
                "org": "Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA; Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA."
            },
            {
                "name": "Ming You",
                "org": "Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA; Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA."
            }
        ],
        "venue": "American journal of human genetics",
        "year": 2015
    },
    "b6oB42E8": {
        "id": "b6oB42E8",
        "title": "Prognostic and predictive significance of thymidylate synthase protein expression in non-small cell lung cancer: a systematic review and meta-analysis.",
        "abstract": "It remains controversial whether thymidylate synthase (TS) protein expression is associated with survival for patients with non-small cell lung cancer (NSCLC).To evaluate prognostic and predictive significance of tumor TS protein level in NSCLC.Electronic searches were performed for relevant studies in PubMed, EMBASE, Web of Science, and Chinese Biomedical Literature Database. Hazard ratios (HRs) for overall survival (OS) and progression-free survival (PFS) were pooled for meta-analysis. Subgroup and sensitivity analyses were performed. Publication bias was evaluated by funnel plot and Begg's test.Twenty-four studies, including 2280 patients, were eligible. This analysis showed that patients with low TS expression had statistically significantly longer OS and PFS than those with high TS (HR=0.51 and HR=0.49, respectively). Based on TS-targeted drug use status, TS expression was significantly associated with OS in pemetrexed (HR=0.42) and 5-Fluorouracil subgroups (HR=0.34), but not in no TS-targeted drug subgroup. There were similar results for PFS analyses. Sensitivity analysis indicated that the results were robust. Begg's test did not reveal any publication bias.Low TS protein expression is a favorable predictive factor for better OS/PFS in NSCLC patients treated with TS-targeted drugs. Prognostic value of TS protein expression needs further validation.",
        "keywords": [
            "non-small cell lung cancer",
            "predictive factor",
            "prognosis",
            "thymidylate synthase"
        ],
        "authors": [
            {
                "name": "Qingyun Liu",
                "org": "Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, China."
            },
            {
                "name": "Zubin Yu",
                "org": "Department of Thoracic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, China."
            },
            {
                "name": "Ying Xiang",
                "org": "Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, China."
            },
            {
                "name": "Na Wu",
                "org": "Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, China."
            },
            {
                "name": "Long Wu",
                "org": "Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, China."
            },
            {
                "name": "Bin Xu",
                "org": "Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, China."
            },
            {
                "name": "Liang Wang",
                "org": "Department of Pathology, MCW Cancer Center, Medical College of Wisconsin, Milwaukee, WI, USA."
            },
            {
                "name": "Ping Yang",
                "org": "Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MI, USA."
            },
            {
                "name": "Yafei Li",
                "org": "Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, China."
            },
            {
                "name": "Li Bai",
                "org": "Department of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, China."
            }
        ],
        "venue": "Cancer biomarkers : section A of Disease markers",
        "year": 2015
    },
    "lrjUNZPv": {
        "id": "lrjUNZPv",
        "title": "Lung cancer in China: challenges and interventions.",
        "abstract": "In 2008, lung cancer replaced liver cancer as the number one cause of death among people with malignant tumors in China. The registered lung cancer mortality rate increased by 464.84% in the past 3 decades, which imposes an enormous burden on patients, health-care professionals, and society. We performed a systematic review of the published data on lung cancer in China between 1990 and 2011 to analyze the incidence and mortality rates, economic burden, and risk factors of cancer and the effectiveness of interventions. Lung cancer incidence varies within China. People in eastern China, especially women, likely have a higher risk of developing lung cancer than those in western China. The crude mortality rates from lung cancer in 2008 were 47.51 per 100,000 men and 22.69 per 100,000 women. The crude mortality rate was highest in Shanghai (76.49 per 100,000 men and 35.82 per 100,000 women) and lowest in Tibet (25.14 per 100,000 men) and Ningxia (12.09 per 100,000 women). Smoking and environmental pollution are major risk factors for lung cancer in China. Continuous efforts should be concentrated on education of the general public regarding lung cancer to increase prevention and early detection. Specific interventions need to be implemented to reduce smoking rates and environmental risk factors. Standardized treatment protocols should be adapted in China.",
        "keywords": [
            "air pollution",
            "china"
        ],
        "authors": [
            {
                "name": "Jun She",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Ping Yang",
                "org": "Mayo Clinic(Mayo Clinic),Rochester,United States"
            },
            {
                "name": "Qunying Hong",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Chunxue Bai",
                "org": "Fudan University(Fudan University),Shanghai,China"
            }
        ],
        "venue": "Chest",
        "year": 2013
    },
    "bb5w2Lrw": {
        "id": "bb5w2Lrw",
        "title": "Identification of independent primary tumors and intrapulmonary metastases using DNA rearrangements in non-small-cell lung cancer.",
        "abstract": "Distinguishing independent primary tumors from intrapulmonary metastases in non-small-cell carcinoma remains a clinical dilemma with significant clinical implications. Using next-generation DNA sequencing, we developed a chromosomal rearrangement-based approach to differentiate multiple primary tumors from metastasis.Tumor specimens from patients with known independent primary tumors and metastatic lesions were used for lineage test development, which was then applied to multifocal tumors. Laser capture microdissection was performed separately for each tumor. Genomic DNA was isolated using direct in situ whole-genome amplification methodology, and next-generation sequencing was performed using an Illumina mate-pair library protocol. Sequence reads were mapped to the human genome, and primers spanning the fusion junctions were used for validation polymerase chain reaction.A total of 41 tumor samples were sequenced (33 adenocarcinomas [ADs] and eight squamous cell carcinomas [SQCCs]), with a range of three to 276 breakpoints per tumor identified. Lung tumors predicted to be independent primary tumors based on different histologic subtype did not share any genomic rearrangements. In patients with lung primary tumors and paired distant metastases, shared rearrangements were identified in all tumor pairs, emphasizing the patient specificity of identified breakpoints. Multifocal AD and SQCC samples were reviewed independently by two pulmonary pathologists. Concordance between histology and genomic data occurred in the majority of samples. Discrepant tumor samples were resolved by genome sequencing.A diagnostic lineage test based on genomic rearrangements from mate-pair sequencing demonstrates promise for distinguishing independent primary from metastatic disease in lung cancer.",
        "keywords": [],
        "authors": [
            {
                "name": "Stephen J Murphy",
                "org": "All authors: Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Marie-Christine Aubry",
                "org": "All authors: Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Faye R Harris",
                "org": "All authors: Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Geoffrey C Halling",
                "org": "All authors: Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Sarah H Johnson",
                "org": "All authors: Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Simone Terra",
                "org": "All authors: Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Travis M Drucker",
                "org": "All authors: Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Michael K Asiedu",
                "org": "All authors: Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Benjamin R Kipp",
                "org": "All authors: Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Eunhee S Yi",
                "org": "All authors: Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Tobias Peikert",
                "org": "All authors: Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Ping Yang",
                "org": "All authors: Mayo Clinic, Rochester, MN."
            },
            {
                "name": "George Vasmatzis",
                "org": "All authors: Mayo Clinic, Rochester, MN. vasmatzis.george@mayo.edu."
            },
            {
                "name": "Dennis A Wigle",
                "org": "All authors: Mayo Clinic, Rochester, MN."
            }
        ],
        "venue": "Journal of clinical oncology : official journal of the American Society of Clinical Oncology",
        "year": 2014
    },
    "0JJeaDYm": {
        "id": "0JJeaDYm",
        "title": "Quality of life and symptom burden among long-term lung cancer survivors.",
        "abstract": "Information is limited regarding health-related quality of life (QOL) status of long-term (greater than 5 years) lung cancer survivors (LTLCS). Obtaining knowledge about their QOL changes over time is a critical step toward improving poor and maintaining good QOL. The primary aim of this study was to conduct a 7-year longitudinal study in survivors of primary lung cancer which identified factors associated with either decline or improvement in QOL over time.Between 1997 and 2003, 447 LTLCS were identified and followed through 2007 using validated questionnaires; data on overall QOL and specific symptoms were at two periods: short-term (less than 3 years) and long-term postdiagnosis. The main analyses were of clinically significant changes (greater than 10%) and factors associated with overall QOL and symptom burden for each period and for changes over time.Three hundred two (68%) underwent surgical resection only and 122 (27%) received surgical resection and radiation/chemotherapy. Recurrent or new lung malignancies were observed in 84 (19%) survivors. Significant decline or improvement in overall QOL over time were reported in 155 (35%) and 67 (15%) of 447 survivors, respectively. Among the 155 whose QOL declined, significantly worsened symptoms were fatigue (69%), pain (59%), dyspnea (58%), depressed appetite (49%), and coughing (42%). The symptom burden did not lessen among the 67 who reported improvement in overall QOL, suggesting that survivors had adapted to their compromised physical condition.LTLCS suffered substantial symptom burden that significantly impaired their QOL, indicating a need for targeted interventions to alleviate their symptoms.",
        "keywords": [],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "Mayo Clinic, College of Medicine, Rochester, Minnesota 55905, USA. yang.ping@mayo.edu"
            },
            {
                "name": "Andrea L Cheville",
                "org": ""
            },
            {
                "name": "Jason A Wampfler",
                "org": ""
            },
            {
                "name": "Yolanda I Garces",
                "org": ""
            },
            {
                "name": "Aminah Jatoi",
                "org": ""
            },
            {
                "name": "Matthew M Clark",
                "org": ""
            },
            {
                "name": "Stephen D Cassivi",
                "org": ""
            },
            {
                "name": "David E Midthun",
                "org": ""
            },
            {
                "name": "Randolph S Marks",
                "org": ""
            },
            {
                "name": "Marie-Christine Aubry",
                "org": ""
            },
            {
                "name": "Scott H Okuno",
                "org": ""
            },
            {
                "name": "Brent A Williams",
                "org": ""
            },
            {
                "name": "Francis C Nichols",
                "org": ""
            },
            {
                "name": "Victor F Trastek",
                "org": ""
            },
            {
                "name": "Hiroshi Sugimura",
                "org": ""
            },
            {
                "name": "Linda Sarna",
                "org": ""
            },
            {
                "name": "Mark S Allen",
                "org": ""
            },
            {
                "name": "Claude Deschamps",
                "org": ""
            },
            {
                "name": "Jeff A Sloan",
                "org": ""
            }
        ],
        "venue": "Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer",
        "year": 2012
    },
    "5REwzgJZ": {
        "id": "5REwzgJZ",
        "title": "Genetic variants of the Wnt signaling pathway as predictors of recurrence and survival in early-stage non-small cell lung cancer patients.",
        "abstract": "Early-stage non-small cell lung cancer (NSCLC) is potentially curative. Nevertheless, many patients will show disease recurrence after curative treatment. The Wnt signaling pathway is a developmental and stem cell pathway that plays an important role in tumorigenesis and may affect cancer progression. We hypothesize that genetic variants of the Wnt pathway may influence clinical outcome in early-stage NSCLC patients. We genotyped 441 functional and tagging single nucleotide polymorphisms (SNPs) from 54 genes of the Wnt pathway in 535 early-stage NSCLC patients treated with curative intent therapy including surgery and chemotherapy. For validation, 4 top SNPs were genotyped in 301 early-stage NSCLC patients from the Mayo Clinic. Cox proportional hazard model and combined SNP analyses were performed to identify significant SNPs correlated with recurrence-free and overall survival. Results from discovery group showed a total of 40 SNPs in 20 genes correlated with disease recurrence (P < 0.05). After correction for multiple comparisons, rs2536182 near Wnt16 remained significant (q < 0.1), which was validated in the replication population. Thirty-nine SNPs in 16 genes correlated with overall survival (P < 0.05) in the discovery group, and seven remained significant after multiple comparisons were considered (q < 0.1). In patients receiving surgery-only treatment, rs10898563 of FZD4 gene was associated with both recurrence-free and overall survival. Joint SNP analyses identified predictive markers for recurrence stratified by treatment. Our findings suggest inherited genetic variation in the Wnt signaling pathway may contribute to variable clinical outcomes for patients with early-stage NSCLC.",
        "keywords": [],
        "authors": [
            {
                "name": "Angela Coscio",
                "org": "Departments of General Oncology, Epidemiology and Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA and Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA."
            },
            {
                "name": "David W Chang",
                "org": "Epidemiology and."
            },
            {
                "name": "Jack A Roth",
                "org": "Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA and."
            },
            {
                "name": "Yuanqing Ye",
                "org": "Epidemiology and."
            },
            {
                "name": "Jian Gu",
                "org": "Epidemiology and."
            },
            {
                "name": "Ping Yang",
                "org": "Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA."
            },
            {
                "name": "Xifeng Wu",
                "org": "Epidemiology and xwu@mdanderson.org."
            }
        ],
        "venue": "Carcinogenesis",
        "year": 2014
    },
    "ONJoxbQT": {
        "id": "ONJoxbQT",
        "title": "Lung cancer in never smokers.",
        "abstract": "Lung cancer in never smokers (LCINS) has lately been recognized as a unique disease based on rapidly gained knowledge from genomic changes to treatment responses. The focus of this article is on current knowledge and challenges with regard to LCINS expanded from recent reviews highlighting five areas: (1) distribution of LCINS by temporal trends, geographic regions, and populations; (2) three well-recognized environmental risk factors; (3) other plausible environmental risk factors; (4) prior chronic lung diseases and infectious diseases as risk factors; and (5) lifestyles as risk or protective factors. This article will also bring attention to recently published literature in two pioneering areas: (1) histological characteristics, clinical features with emerging new effective therapies, and social and psychological stigma; and (2) searching for susceptibility genes using integrated genomic approaches.",
        "keywords": [
            "genomics",
            "risk factors"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. yang.ping@mayo.edu"
            }
        ],
        "venue": "Seminars in respiratory and critical care medicine",
        "year": 2011
    },
    "nCCjTqVY": {
        "id": "nCCjTqVY",
        "title": "FoxM1 mediated resistance to gefitinib in non-smallcell lung cancer cells",
        "abstract": "Aim: Gefitinib is effective in only approximately 20% of patients with non-small-cell lung cancer (NSCLC), and the underlying mechanism remains unclear. FoxM1 is upregulated in NSCLC and associated with a poor prognosis in NSCLC patients. In this study, we examined the possible role of FoxM1 in gefitinib resistance and the related mechanisms. Methods: Gefitinib resistant human lung adenocarcinoma cell line SPC-A-1 and gefitinib-sensitive human lung mucoepidermoid carcinoma cell line NCI-H292 were used. mRNA and protein expression of FoxM1 and other factors were tested with quantitative RT PCR and Western blot analysis. RNA interference was performed to suppress FoxM1 expression in SPC-A-1 cells, and lentiviral infection was used to overexpress FoxM1 in H292 cells. MTT assay and flow cytometry were used to examine the proliferation and apoptosis of the cells. Results: Treatment of SPC-A-1 cells with gefitinib (1 and 10mol/L) upregulated the expression of FoxM1 in time-and concentration-dependent manners, while gefitinib (1mol/L) downregulated in H292 cells. In SPC-A-1 cells treated with gefitinib (1mol/L), the expression of several downstream targets of FoxM1, including survivin, cyclin B1, SKP2, PLK1, Aurora B kinase and CDC25B, were significantly upregulated. Overexpression of FoxM1 increased the resistance in H292 cells, while attenuated FoxM1 expression restored the sensitivity to gefitinib in SPC-A-1 cells by inhibiting proliferation and inducing apoptosis.Conclusion:The results suggest that FoxM1 plays an important role in the resistance of NSCLC cells to gefitinib in vitro. FoxM1 could be used as a therapeutic target to overcome the resistance to gefitinib. \u00a9 2012 CPS and SIMM. All rights reserved.",
        "keywords": [
            "drug resistance",
            "foxm1",
            "gefitinib",
            "human lung adenocarcinoma cell",
            "human lung mucoepidermoid carcinoma cell",
            "non-small-cell lung cancer",
            "rna interference",
            "pharmaceutics",
            "signal transduction",
            "clinical pharmacology",
            "cell proliferation",
            "genitourinary",
            "pharmacology",
            "pharmacokinetics",
            "apoptosis",
            "real time polymerase chain reaction",
            "neuropharmacology",
            "flow cytometry",
            "drug discovery"
        ],
        "authors": [
            {
                "name": "Nuo Xu",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Xin Zhang",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Xun Wang",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Hai-yan Ge",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Xiao-ying Wang",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "David H. Garfield",
                "org": "ProMed Cancer Centers-Shanghai(ProMed Cancer Centers-Shanghai,ProMed Cancer Centers - Shanghai,Medical ProMed Cancer Centers Shanghai,Promed Cancer Centers-Shanghai),Shanghai,China"
            },
            {
                "name": "Ping Yang",
                "org": "Mayo Clinic(Mayo Clinic),Rochester,United States"
            },
            {
                "name": "Yuan-lin Song",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Chun-xue Bai",
                "org": "Fudan University(Fudan University),Shanghai,China"
            }
        ],
        "venue": "Acta Pharmacologica Sinica",
        "year": 2012
    },
    "IswHfASa": {
        "id": "IswHfASa",
        "title": "Trends in Subpopulations at High Risk for Lung Cancer.",
        "abstract": "Two-thirds of patients in the United States with newly diagnosed lung cancer would not meet the current U.S. Preventive Services Task Force (USPSTF) screening criteria, which suggests a need for amendment of the definition of high risk. To provide evidence of additional high-risk subpopulations and estimated gains and losses from using different criteria for screening eligibility, we conducted a two-step study using three cohorts.The two prospective cohorts comprised 5988 patients in whom primary lung cancer was diagnosed between 1997 and 2011 (the hospital cohort) and 850 defined-community residents (the community cohort); the retrospective cohort consisted of the population of Olmsted County, Minnesota, which was observed for 28 years (1984-2011). Subgroups of patients with lung cancer who might have been identified using additional determinates were estimated and compared between the community and hospital cohorts. The findings were supported by indirect comparative projections of two ratios: benefit to harm and cost to effectiveness.Former cigarette smokers who had a smoking history of 30 or more pack-years and 15 to 30 quit-years and were 55 to 80 years old formed the largest subgroup not meeting the current screening criteria; they constituted 12% of the hospital cohort and 17% of community cohort. Using the expanded criteria suggested by our study may add 19% more CT examinations for detecting 16% more cases when compared with the USPSTF criteria. Meanwhile, the increases in false-positive results, overdiagnosis, and radiation-related lung cancer deaths are 0.6%, 0.1%, and 4.0%, respectively.Current USPSTF screening criteria exclude many patients who are at high risk for development of lung cancer. Including individuals who are younger than 81 years, have a smoking history of 30 or more pack-years, and have quit for 15 to 30 years may significantly increase the number of cases of non-overdiagnosed screen-detected lung cancer, does not significantly add to the number of false-positive cases, and saves more lives with an acceptable amount of elevated exposure to radiation and cost.",
        "keywords": [
            "Former smokers",
            "Low-dose CT",
            "Lung cancer",
            "Screening",
            "Smoking cessation"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA."
            },
            {
                "name": "Yi Wang",
                "org": "School of Environmental Science and Public Health, Wenzhou Medical University, Chashan University Town, Wenzhou, Zhejiang Province, People's Republic of China."
            },
            {
                "name": "Jason A Wampfler",
                "org": "Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA."
            },
            {
                "name": "Dong Xie",
                "org": "Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Yangpu District, Shanghai, People's Republic of China."
            },
            {
                "name": "Shawn M Stoddard",
                "org": "School of Environmental Science and Public Health, Wenzhou Medical University, Chashan University Town, Wenzhou, Zhejiang Province, People's Republic of China."
            },
            {
                "name": "Jun She",
                "org": "Shanghai Respiratory Institute, Fudan University, No. 83 Wanghangdu Road, Jing'an District, Shanghai, People's Republic of China."
            },
            {
                "name": "David E Midthun",
                "org": "Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA."
            }
        ],
        "venue": "Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer",
        "year": 2016
    },
    "SPZiS0Ar": {
        "id": "SPZiS0Ar",
        "title": "Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA.",
        "abstract": "miRNAs play key regulatory roles in cellular pathological processes. We aimed to identify clinically meaningful biomarkers in pulmonary carcinoid tumors (PCTs), a member of neuroendocrine neoplasms, via profiling miRNAs and mRNAs.From the total of 1145 miRNAs, we obtained 16 and 17 miRNAs that showed positive and negative fold changes (FCs, tumors vs. normal tissues) in the top 1% differentially expressed miRNAs, respectively. We uncovered the target genes that were predicted by at least two prediction tools and overlapped by at least one-half of the top miRNAs, which yielded 44 genes (FC<-2) and 56 genes (FC>2), respectively. Higher expressions of CREB5, PTPRB and COL4A3 predicted favorable disease free survival (Hazard ratio: 0.03, 0.19 and 0.36; P value: 0.03, 0.03 and 0.08). Additionally, 79 mutated genes have been found in nine PCTs where TP53 was the only repeated mutation.We identified that the expressions of three genes have clinical implications in PCTs. The biological functions of these biomarkers warrant further studies.",
        "keywords": [
            "carcinoid",
            "survival",
            "mrna",
            "mirna",
            "cell biology",
            "biomedical research",
            "microbiology",
            "bioinformatics"
        ],
        "authors": [
            {
                "name": "Bo Deng",
                "org": "Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, USA ; Thoracic Surgery Department, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People's Republic of China."
            },
            {
                "name": "Julian Molina",
                "org": "Department of Oncology, Division of Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA."
            },
            {
                "name": "Marie C Aubry",
                "org": "Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA."
            },
            {
                "name": "Zhifu Sun",
                "org": "Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, USA."
            },
            {
                "name": "Liang Wang",
                "org": "Department of Pathology, Medical College of Wisconsin Cancer Center, Milwaukee, Wisconsin, USA."
            },
            {
                "name": "Bruce W Eckloff",
                "org": "Medical Genome Facility, Mayo Clinic College of Medicine, Rochester, Minnesota, USA."
            },
            {
                "name": "George Vasmatzis",
                "org": "Department of Molecular Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA."
            },
            {
                "name": "Ming You",
                "org": "Department of Cancer Center and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA."
            },
            {
                "name": "Eric D Wieben",
                "org": "Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA."
            },
            {
                "name": "Jin Jen",
                "org": "Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA."
            },
            {
                "name": "Dennis A Wigle",
                "org": "Department of Surgery, Division of General Thoracic Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota, USA."
            },
            {
                "name": "Ping Yang",
                "org": "Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, USA."
            }
        ],
        "venue": "Cell & bioscience",
        "year": 2014
    },
    "zg0onY9E": {
        "id": "zg0onY9E",
        "title": "Early venous thromboembolic events are associated with worse prognosis in patients with lung cancer.",
        "abstract": "Venous thromboembolic events (VTE) are a leading cause of death in cancer patients. We hypothesized that early VTE (EVTE, within 3 months of diagnosis) in patients with lung cancer (LC) are associated with worse overall survival (OS).We identified 727 patients with LC between 1998 and 2011. Late VTE (LVTE) were defined as VTE occurring after 3 months from LC diagnosis. Advance disease (AD) was defined as patients with Stage IV non-small cell lung cancer (NSCLC) or extensive stage small cell lung cancer (SCLC), and non-advanced disease (non-AD) was defined as \u2264 Stage III NSCLC or limited stage SCLC.Out of 727 patients included in our review, 617 patients had NSCLC (85%), 94 (13%) SCLC, and 16 (2%) low grade neuroendocrine tumors. Ninety five patients (13%) experienced VTE, 44 (6%) experienced an EVTE and 49 (7%) had a LVTE. Patients with an EVTE had worse OS when compared to all other patients (medians 4 vs. 17 months, p < 0.0001). EVTE were associated with worse OS in patients with non-AD (medians 12 vs. 42 months, p = 0.01) and AD (medians 4 vs. 6 months, p = 0.02). When considering patients with NSCLC only, in a multivariate model that included age, stage, performance status >2, administration of chemotherapy and Charlson comorbidity index, EVTE were an independent predictor of increased mortality (HR 2.4; 95% CI 1.6-3.3).EVTE are associated with worse OS, irrespective of stage of the disease. Our findings underscore the need for an efficient preventive strategy for VTE among patients with lung cancer.",
        "keywords": [
            "incidence",
            "lung neoplasms",
            "prognosis",
            "survival",
            "thrombosis",
            "venous thromboembolism",
            "os",
            "esa"
        ],
        "authors": [
            {
                "name": "Taxiarchis V Kourelis",
                "org": "Department of Medical Oncology, Mayo Clinic, Rochester, MN, USA."
            },
            {
                "name": "Ewa M Wysokinska",
                "org": "Department of Medical Oncology, Mayo Clinic, Rochester, MN, USA."
            },
            {
                "name": "Yi Wang",
                "org": "Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA; Division of Preventive Medicine, School of Environmental Science and Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China."
            },
            {
                "name": "Ping Yang",
                "org": "Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA."
            },
            {
                "name": "Aaron S Mansfield",
                "org": "Department of Medical Oncology, Mayo Clinic, Rochester, MN, USA."
            },
            {
                "name": "Alfonso J Tafur",
                "org": "Section of Cardiology - Vascular Medicine, Oklahoma University Health Sciences Center, USA."
            }
        ],
        "venue": "Lung cancer (Amsterdam, Netherlands)",
        "year": 2014
    },
    "QUtbTfc1": {
        "id": "QUtbTfc1",
        "title": "Polymorphisms in GLTSCR1 and ERCC2 are associated with the development of oligodendrogliomas.",
        "abstract": "Deletions of 19q have been associated with gliomas, especially oligodendrogliomas. In addition, cases with oligodendrogliomas with the 19q deletion have been observed to have a better survival compared with cases without the 19q deletion. The authors have previously described a 150-kilobase minimal deletion region in gliomas that maps to 19q13.33 and contains 3 novel candidate genes (GLTSCR1, EHD2, and GLTSCR2).The authors performed an association study using 141 cases with gliomas (61 cases with astrocytomas, 40 cases with oligodendrogliomas, 40 cases with mixed oligoastrocytomas) and 108 general controls. They evaluated 7 single nucleotide polymorphisms (SNPs) in 6 genes within and nearby the minimal 19q deletion region (ERCC2, RAI, ASE-1, ERCC1, GLTSCR1, and LIG1).The prevalence of a germline GLTSCR1-exon-1 T allele (SNP rs1035938) was 40% in cases with oligodendrogliomas compared with 27% in controls (P = 0.029), and the prevalence of an ERCC2-exon-22 T allele (SNP rs1052555) was 35% in cases with oligodendrogliomas compared with 18% in controls (P = 0.043). One high-risk and 1 low-risk haplotype were associated with oligodendroglioma development (P = 0.003 and 0.026, respectively). Cases with oligodendrogliomas with the 19q deletion had a significantly higher frequency of the GLTSCR1-exon-1 T allele compared with cases without the 19q deletion (P = 0.01). It was noteworthy that cases with gliomas who were homozygous for the GLTSCR1-exon-1 T allele had a significantly better survival: 77% and 68% survival at 2 and 5 years compared with 56% and 34% for other genotypes (P = 0.02, log-rank test). Multivariable analysis identified grade, age, and the GLTSCR1-exon-1 and ERCC2-exon-22 genotypes as independent predictors for survival.These results suggested that alterations in GLTSCR1 (or a closely linked gene) were associated with the development and progression of oligodendroglioma.",
        "keywords": [],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA. yang.ping@mayo.edu"
            },
            {
                "name": "Thomas M Kollmeyer",
                "org": ""
            },
            {
                "name": "Kristin Buckner",
                "org": ""
            },
            {
                "name": "William Bamlet",
                "org": ""
            },
            {
                "name": "Karla V Ballman",
                "org": ""
            },
            {
                "name": "Robert B Jenkins",
                "org": ""
            }
        ],
        "venue": "Cancer",
        "year": 2005
    },
    "MKmeIGG1": {
        "id": "MKmeIGG1",
        "title": "Clinical outcomes and changes in lung function after segmentectomy versus lobectomy for lung cancer cases.",
        "abstract": "We compared the clinical outcomes and changes in pulmonary function test (PFT) results after segmentectomy or lobectomy for non-small cell lung cancer.The retrospective study included 212 patients who had undergone segmentectomy (group S) and 2336 patients who had undergone lobectomy (group L) from 1997 to 2012. The follow-up and medical record data were collected. We used all the longitudinal PFT data within 24 months postoperatively and performed linear mixed modeling. We analyzed the 5-year overall and disease-free survival in stage IA patients. We used propensity score case matching to minimize the bias due to imbalanced group comparisons.During the perioperative period, 1 death (0.4%) in group S and 7 (0.3%) in group L occurred. The hospital stay for the 2 groups was similar (median, 5.0 vs 5.0 days; range, 2-99 vs 2-58). The mean overall and disease-free survival period of those with T1a after segmentectomy or lobectomy seemed to be similar (4.2 vs 4.5 years, P=.06; and 4.1 vs 4.4 years, P=.07, respectively). Compared with segmentectomy, lobectomy yielded marginally significantly better overall (4.4 vs 3.9 years, P=.05) and disease-free (4.1 vs 3.6 years; P=.05) survival in those with T1b. We did not find a significantly different effect on the PFTs after segmentectomy or lobectomy.Both surgical types were safe. We would advocate lobectomy for patients with stage IA disease, especially those with T1b. A retrospective study with a large sample size and more detailed information should be conducted for PFT evaluation, with additional stratification by lobe and laterality.",
        "keywords": [
            "pulmonary function test",
            "fev1",
            "dfs",
            "os",
            "propensity scores"
        ],
        "authors": [
            {
                "name": "Bo Deng",
                "org": "Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minn; Department of Thoracic Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, People's Republic of China."
            },
            {
                "name": "Stephen D Cassivi",
                "org": "Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic College of Medicine, Rochester, Minn."
            },
            {
                "name": "Mariza de Andrade",
                "org": "Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minn."
            },
            {
                "name": "Francis C Nichols",
                "org": "Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic College of Medicine, Rochester, Minn."
            },
            {
                "name": "Victor F Trastek",
                "org": "Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic College of Medicine, Rochester, Minn."
            },
            {
                "name": "Yi Wang",
                "org": "Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minn; School of Environmental Science and Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China."
            },
            {
                "name": "Jason A Wampfler",
                "org": "Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minn."
            },
            {
                "name": "Shawn M Stoddard",
                "org": "Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minn."
            },
            {
                "name": "Dennis A Wigle",
                "org": "Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic College of Medicine, Rochester, Minn."
            },
            {
                "name": "Robert K Shen",
                "org": "Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic College of Medicine, Rochester, Minn."
            },
            {
                "name": "Mark S Allen",
                "org": "Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic College of Medicine, Rochester, Minn."
            },
            {
                "name": "Claude Deschamps",
                "org": "Division of General Thoracic Surgery, Department of Surgery, Mayo Clinic College of Medicine, Rochester, Minn."
            },
            {
                "name": "Ping Yang",
                "org": "Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minn."
            }
        ],
        "venue": "The Journal of thoracic and cardiovascular surgery",
        "year": 2014
    },
    "l7evtebI": {
        "id": "l7evtebI",
        "title": "Trends in the proportion of patients with lung cancer meeting screening criteria.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Yi Wang",
                "org": "Division of Epidemiology, Mayo Clinic, Rochester, Minnesota4Dr Wang is now with the Division of Preventive Medicine, Wenzhou Medical University, Wenzhou, China."
            },
            {
                "name": "David E Midthun",
                "org": "Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota."
            },
            {
                "name": "Jason A Wampfler",
                "org": "Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota."
            },
            {
                "name": "Bo Deng",
                "org": "Division of Epidemiology, Mayo Clinic, Rochester, Minnesota."
            },
            {
                "name": "Shawn M Stoddard",
                "org": "Division of Epidemiology, Mayo Clinic, Rochester, Minnesota."
            },
            {
                "name": "Shuo Zhang",
                "org": "Division of Epidemiology, Mayo Clinic, Rochester, Minnesota."
            },
            {
                "name": "Ping Yang",
                "org": "Division of Epidemiology, Mayo Clinic, Rochester, Minnesota."
            }
        ],
        "venue": "JAMA",
        "year": 2015
    },
    "lSqVETmJ": {
        "id": "lSqVETmJ",
        "title": "Common Oncogene Mutations and Novel SND1-BRAF Transcript Fusion in Lung Adenocarcinoma from Never Smokers.",
        "abstract": "Lung adenocarcinomas from never smokers account for approximately 15 to 20% of all lung cancers and these tumors often carry genetic alterations that are responsive to targeted therapy. Here we examined mutation status in 10 oncogenes among 89 lung adenocarcinomas from never smokers. We also screened for oncogene fusion transcripts in 20 of the 89 tumors by RNA-Seq. In total, 62 tumors had mutations in at least one of the 10 oncogenes, including EGFR (49 cases, 55%), K-ras (5 cases, 6%), BRAF (4 cases, 5%), PIK3CA (3 cases, 3%), and ERBB2 (4 cases, 5%). In addition to ALK fusions identified by IHC/FISH in four cases, two previously known fusions involving EZR- ROS1 and KIF5B-RET were identified by RNA-Seq as well as a third novel fusion transcript that was formed between exons 1-9 of SND1 and exons 2 to 3' end of BRAF. This in-frame fusion was observed in 3/89 tested tumors and 2/64 additional never smoker lung adenocarcinoma samples. Ectopic expression of SND1-BRAF in H1299 cells increased phosphorylation levels of MEK/ERK, cell proliferation, and spheroid formation compared to parental mock-transfected control. Jointly, our results suggest a potential role of the novel BRAF fusion in lung cancer development and therapy.",
        "keywords": [],
        "authors": [
            {
                "name": "Jin Sung Jang",
                "org": "Departments of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Adam Lee",
                "org": "Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Jun Li",
                "org": "1] Departments of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN [2] Department of Oncology and Hematology, China-Japan Union Hospital of Jilin University, Jilin, China."
            },
            {
                "name": "Hema Liyanage",
                "org": "Sequenom, Inc., San Diego, CA, USA."
            },
            {
                "name": "Yanan Yang",
                "org": "Departments of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Lixia Guo",
                "org": "Departments of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Yan W Asmann",
                "org": "Health Science Research, Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Peter W Li",
                "org": "Health Science Research, Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Michele Erickson-Johnson",
                "org": "Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Yuta Sakai",
                "org": "Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN."
            },
            {
                "name": "ZhiFu Sun",
                "org": "Health Science Research, Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Hyo-Sung Jeon",
                "org": "Molecular Diagnostics and Imaging Center, School of Medicine, Kyungpook National University, Daegu, Korea."
            },
            {
                "name": "Hayoung Hwang",
                "org": "New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Korea."
            },
            {
                "name": "Aaron O Bungum",
                "org": "Departments of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Eric S Edell",
                "org": "Departments of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Vernadette A Simon",
                "org": "Gene Expression Core, Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Karla J Kopp",
                "org": "Biospecimen Accessioning and Processing Core, Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Bruce Eckloff",
                "org": "DNA Sequencing Core, Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Andre M Oliveira",
                "org": "Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Eric Wieben",
                "org": "DNA Sequencing Core, Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Marie Christine Aubry",
                "org": "Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Eunhee Yi",
                "org": "Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Dennis Wigle",
                "org": "Thoracic Surgery, Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Robert B Diasio",
                "org": "Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Ping Yang",
                "org": "Health Science Research, Mayo Clinic, Rochester, MN."
            },
            {
                "name": "Jin Jen",
                "org": "1] Departments of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN [2] Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN [3] Gene Expression Core, Mayo Clinic, Rochester, MN."
            }
        ],
        "venue": "Scientific reports",
        "year": 2015
    },
    "0cKUmm3T": {
        "id": "0cKUmm3T",
        "title": "Dopamine D2 receptor agonists inhibit lung cancer progression by reducing angiogenesis and tumor infiltrating myeloid derived suppressor cells.",
        "abstract": "We sought to determine whether Dopamine D2 Receptor (D2R) agonists inhibit lung tumor progression and identify subpopulations of lung cancer patients that benefit most from D2R agonist therapy. We demonstrate D2R agonists abrogate lung tumor progression in syngeneic (LLC1) and human xenograft (A549) orthotopic murine models through inhibition of tumor angiogenesis and reduction of tumor infiltrating myeloid derived suppressor cells. Pathological examination of human lung cancer tissue revealed a positive correlation between endothelial D2R expression and tumor stage. Lung cancer patients with a smoking history exhibited greater levels of D2R in lung endothelium. Our results suggest D2R agonists may represent a promising individualized therapy for lung cancer patients with high levels of endothelial D2R expression and a smoking history.",
        "keywords": [
            "angiogenesis",
            "cabergoline",
            "dopamine",
            "dopamine d2 receptor agonists",
            "lung cancer",
            "vegf",
            "alk1",
            "vascular endothelial growth factor a",
            "d2r",
            "dopamine d2 receptor",
            "myeloid derived suppressor cells",
            "da",
            "ros",
            "reactive oxygen species"
        ],
        "authors": [
            {
                "name": "Luke H Hoeppner",
                "org": "Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA."
            },
            {
                "name": "Ying Wang",
                "org": "Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA."
            },
            {
                "name": "Anil Sharma",
                "org": "Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA."
            },
            {
                "name": "Naureen Javeed",
                "org": "Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA."
            },
            {
                "name": "Virginia P Van Keulen",
                "org": "Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA."
            },
            {
                "name": "Enfeng Wang",
                "org": "Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA."
            },
            {
                "name": "Ping Yang",
                "org": "Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA; Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA."
            },
            {
                "name": "Anja C Roden",
                "org": "Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA."
            },
            {
                "name": "Tobias Peikert",
                "org": "Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA; Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA."
            },
            {
                "name": "Julian R Molina",
                "org": "Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA; Department of Medicine, Division of Medical Oncology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA."
            },
            {
                "name": "Debabrata Mukhopadhyay",
                "org": "Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA."
            }
        ],
        "venue": "Molecular oncology",
        "year": 2015
    },
    "PKEze6nd": {
        "id": "PKEze6nd",
        "title": "Optimization of technological conditions of tilapia scraps enzymatic hydrolysates chelated with zinc by quadratic regression orthogonal rotary",
        "abstract": "In order to optimize the chelating conditions of tilapia scraps enzymatic hydrolysates and the zinc sulfate,based on the single factor test,quadratic regression orthogonal rotary method was chosen,and best results were obtained:AA/Zn 2+ ratio 2.70\u22361,temperature 71.3\u2103,time 15min,pH6.86. By best conditions,the rate of chelation reached 87.56% ,and the important order of each factors was:AA/Zn 2 + ratio >pH >temperature > time.",
        "keywords": [
            "Tilapia scraps",
            "chelation",
            "enzymatic hydrolysates",
            "quadratic regression orthogonal rotary"
        ],
        "authors": [
            {
                "name": "LI Tong-gang",
                "org": "College of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "HONG Peng-zhi",
                "org": "College of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "ZHAO Yang",
                "org": "College of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            }
        ],
        "venue": "Science and Technology of Food Industry",
        "year": 2013
    },
    "29E0PSax": {
        "id": "29E0PSax",
        "title": "Research progress in the formation and deodorization technology of fishy odor for aquatic product",
        "abstract": "Fishy odor in aquatic materials has been generally considered as a major constraint to the processing and consumption of aquatic products. Thus studying the fishy odor formation and deodorization is of great significance to marine industry. In this review,the advances of fishy odor formation mechanism,its characteristic ingredients and deodorization technology for aquatic products were discussed,and the aim was to provide reference for the deodorization of aquatic products and high-tech products development.",
        "keywords": [
            "aquatic product",
            "formation mechanism",
            "fishy odor",
            "deodorization technology"
        ],
        "authors": [
            {
                "name": "HONG Wei",
                "org": "Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety,Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution,College of Food Science and Technology, Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "ZHOU Chun-xia",
                "org": "Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety,Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution,College of Food Science and Technology, Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "HONG Peng-zhi",
                "org": "Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety,Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution,College of Food Science and Technology, Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety,Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution,College of Food Science and Technology, Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "WANG Yun",
                "org": "Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety,Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution,College of Food Science and Technology, Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "QI Man",
                "org": "Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety,Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution,College of Food Science and Technology, Guangdong Ocean University,Zhanjiang ,China"
            }
        ],
        "venue": "Science and Technology of Food Industry",
        "year": 2013
    },
    "xizpWBvR": {
        "id": "xizpWBvR",
        "title": "Analysis of nutritive value of the attritioning bone powder of Tilapia byproduct hydrolysate",
        "abstract": "The content of protein in the ultrafine tilapia bone powder was 21.3%(dry basis), fat 1.5%, ash 73.97%, Ca 28.4 g/100 g, P 12 g/100 g, the ratio of Ca and P 2.37\u22361 and Fe 26 mg/100 g. Therefore, the attritioning tilapia bone powder had the characteristics of higher protein, lower fat and abundant minerals. The total content of 8 essential amino acids was 4.41%, which accounted for 22.73% in the total amino acid.",
        "keywords": [
            "Nutrient content",
            "ultrafine",
            "Bone powder"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "School of Food Science and Technology, Guangdong Ocean University, Zhanjiang,Guangdong ,China"
            },
            {
                "name": "ZHANG Chao-hua",
                "org": "School of Food Science and Technology, Guangdong Ocean University, Zhanjiang,Guangdong ,China"
            },
            {
                "name": "JI Hong-wu",
                "org": "School of Food Science and Technology, Guangdong Ocean University, Zhanjiang,Guangdong ,China"
            },
            {
                "name": "LIU Shu-cheng",
                "org": "School of Food Science and Technology, Guangdong Ocean University, Zhanjiang,Guangdong ,China"
            },
            {
                "name": "HAO Ji-ming",
                "org": "School of Food Science and Technology, Guangdong Ocean University, Zhanjiang,Guangdong ,China"
            },
            {
                "name": "ZHANG Jing",
                "org": "School of Food Science and Technology, Guangdong Ocean University, Zhanjiang,Guangdong ,China"
            }
        ],
        "venue": "Food & Machinery",
        "year": 2007
    },
    "LkciNBeV": {
        "id": "LkciNBeV",
        "title": "Study on the removal of fish odour and bitter from protein hydrolysates of tilapia by-products by microorganism fermentation",
        "abstract": "This work is to compare the effects of removing fish odour and bitter in protein hydrolysates of tilapia Oreochromis niloticus wastes by different microorganisms fermentations,in which lactic acid bacteria such as Streptococus thermophilus,Lactobacillus helveticus,L.bulgaricus and yeasts were used. The removal potency of fish odour and bitter was evaluated by sensory test. The results indicated that the effect of fish odour removal from protein hydrolysates by lactic acid bacteria fermentation was better than by yeasts,in which the best microorganism was S.thermophilus. The optimal conditions for S.thermophilus fermentation were 42\u2103 for temperature and 9 h for time with 10%inoculation volume. There was little effect to remove bitter taste from protein hydrolysates by microorganism.",
        "keywords": [
            "microorganism fermentation",
            "bitter",
            "protein hydrolysates",
            "fish odour",
            "tilapia",
            "fermentation",
            "temperature",
            "bitterness",
            "sensory evaluation",
            "fish"
        ],
        "authors": [
            {
                "name": "ZENG Shaokui",
                "org": "The Faculty of Food Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "YANG Ping",
                "org": "The Faculty of Food Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "CHEN Xiuhong",
                "org": "The Faculty of Food Technology,Guangdong Ocean University,Zhanjiang ,China"
            }
        ],
        "venue": "South China Fisheries Science",
        "year": 2009
    },
    "KPwc5fYG": {
        "id": "KPwc5fYG",
        "title": "Studies on the fishy odour removal and physicochemical properties of gelatin from Nile tilapia (Oreochromis niloticus) skin",
        "abstract": "Nile tilapia (Oreochromis niloticus) aquaculture is expanding throughout the world,most notably in China. According to the statistics of FAO,annual China\u2019s production of tilapia by 2008 had risen to nearly 1.2 million tons,which accounts for about 50% of tilapia production in the world. During processing of tilapia to fillets,large quantities of the by-products such as skin are produced. On one hand,collagen contents in tilapia skins are rich. On the other hand,the bovine spongiform encephalopathy (BSE) episode,as well as religious concerns,has led to intensive research to identify and develop alternatives to mammal-derived gelatin. Therefore,tilapia skin can be a good resource of extracting gelatin. However,gelatin extraction from tilapia skin usually had a strong fishy odour,which would limit its utilization. In order to be applied to food and pharmaceutical industries,some methods must be adopted to make the gelatin odorless. In the present study,methods of active carbon absorption,yeast and lactobacillus fermentation were used to remove fishy odour in the gelatin,in which their roles to diminish fishy odour were compared with each other by sensory analysis. And the effects of active carbon absorption conditions on the transmittance and sensory scores of the gelatin solution were studied by orthogonal experiments. After removing fishy odour,the physicochemical properties of the gelatin were studied and its volatile components were evaluated by simultaneous distillation-extraction (SDE) and gas chromatography-mass spectrometry (GC-MS). Sensory analysis showed that the effects of fishy odour removal of gelatin were significantly different among methods of active carbon absorption,yeast and lactobacillus fermentation (P<0.05). Among these methods,the best one was active carbon absorption. The results of orthogonal experiment indicated that the optimal conditions were the ratio of active carbon addition to 5% (w/v) gelatin solution 1.5% (w/v),and incubated at 40 \u2103 for 30 min. After removal treatment,fishy odour in the tilapia skin gelatin was barely detectable. The content of crude protein in the gelatin was 91.3% and its gel strength was high up to 301 g. The transmittance of the tilapia skin gelatin solution was higher than before treatment,and the content of water-undissolved matter was diminished. A total of 33 volatile components in tilapia skin gelatin solution before removing fishy odour were detected by simultaneous distillation-extraction (SDE) and gas chromatography-mass spectrometry (GC-MS). The volatile compounds of the gelatin solution were predominantly esters,followed by alcohols,ketones and olefines. After removing fishy odour,a total of volatile components in gelatin solution have been diminished to 26 kinds,which were mainly olefines and ketones. The research shows that active carbon absorption appears as a suitable technique to remove fishy odour in tilapia skin gelatin and to improve their physicochemical properties. So,it can be used for industrial production of fishy odour free tilapia skin gelatin.",
        "keywords": [
            "gelatin",
            "Nile tilapia",
            "physicochemical properties",
            "volatile components",
            "fishy odour",
            "skin"
        ],
        "authors": [
            {
                "name": "ZENG Shao-kui",
                "org": " The Faculty of Food Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "YANG Ping",
                "org": " The Faculty of Food Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "DENG Chu-jin",
                "org": " The Faculty of Food Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "HONG Peng-zhi",
                "org": " The Faculty of Food Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "CUI Qi-shan",
                "org": " The Faculty of Food Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "ZHANG Chao-hua",
                "org": " The Faculty of Food Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "LI Lai-hao",
                "org": " South China Sea Fishery Research Institute,Chinese Academy of Fishery Sciences,Guangzhou ,China"
            }
        ],
        "venue": "Journal of Fisheries of China",
        "year": 2010
    },
    "OXasw1GF": {
        "id": "OXasw1GF",
        "title": "STUDY ON ENZYMATIC HYDROLYSIS TO PROTEIN FROM DECAPTERUS MARUADSI",
        "abstract": "The optimal hydrolysis conditions of the Decapterus maruadsi by neutral protease and papain were obtained. The hydrolysis effects of neutral protease and papain singly and double were compared. The conditions of two enzymes were studied by the orthogonal experiment. The results indicated that the effect of hydrolysis was the best by adding papain and neutral protease simultaneously. Under the optimal conditions,the content of amino acid nitrogen was 2.48 g/L in hydrolysis solution,the recovery rate of nitrogen was 91.27 %.",
        "keywords": [
            "emzymolysis",
            "Decapterus maruadsi",
            "protease"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,Guangdong,China"
            },
            {
                "name": "HONG Peng-zhi",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,Guangdong,China"
            },
            {
                "name": "HUANG Kai",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,Guangdong,China"
            }
        ],
        "venue": "Food Research and Development",
        "year": 2007
    },
    "crQahLQk": {
        "id": "crQahLQk",
        "title": "Study on the Formula of Cookie with Ultrafine Tilapia Bone Powder",
        "abstract": "The factors that affected the quality of tilapia bone powder biscuit which were studied. Such as quantity of ultrafine tilapia bone powder,quantity of starch,quantity of Margarine,quantity of sugar,yield of biscuit quality of the tilapia bone powder biscuit were studied with orthogonal experiment. The experimental results indicated that the optimum formula of the tilapia bone powder biscuit: flour 100, the tilapia bone powder 10 %, starch 60 %, Margarine 120 %, sugar 50 %, and proper essence and.",
        "keywords": [
            "ultrafine tilapia bone powder",
            "biscuit",
            "formula"
        ],
        "authors": [
            {
                "name": "LI Xiu-juan",
                "org": "Guangdong Ocean University College of Food Science and Technology, Zhanjiang , Guangdong, China"
            },
            {
                "name": "JIANG Zhi-hong",
                "org": "Guangdong Ocean University College of Food Science and Technology, Zhanjiang , Guangdong, China"
            },
            {
                "name": "YANG Ping",
                "org": "Guangdong Ocean University College of Food Science and Technology, Zhanjiang , Guangdong, China"
            },
            {
                "name": "PENG Qiu-sheng",
                "org": "Guangdong Ocean University College of Food Science and Technology, Zhanjiang , Guangdong, China"
            },
            {
                "name": "ZHUO Er-mei",
                "org": "Guangdong Ocean University College of Food Science and Technology, Zhanjiang , Guangdong, China"
            }
        ],
        "venue": "Food Research and Development",
        "year": 2010
    },
    "H0r0Wxhz": {
        "id": "H0r0Wxhz",
        "title": "Study on Effect of Membrane Separation of Tuna Head Protein Hydrolysates",
        "abstract": "This study used the microporous filters and ultrafiltration to filter the tuna haed protein hydrolysates and compared the properties and thermostability between original fluid and two filtrates.The result indicated that microporous membrane filters and ultrafiltration were good for clarifying,deodorizing and the thermostability of tuna haed protein hydrolysates and with the aperture reduces their effect enhanced.The protein contents of filtering medium of the microporous filtration of 0.45 \u03bcm and 0.22 \u03bcm and 10 000 u ultrafiltration a little reduced and had no effect on amino nitrogen.",
        "keywords": [
            "tuna",
            "enzymatic hydrolysis",
            "microporous membrane",
            "ultrafiltration"
        ],
        "authors": [
            {
                "name": "JI Li-na",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,Guangdong,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,Guangdong,China"
            },
            {
                "name": "LIANG Sheng",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,Guangdong,China"
            }
        ],
        "venue": "Food Research and Development",
        "year": 2012
    },
    "4gkOwKuS": {
        "id": "4gkOwKuS",
        "title": "Effect of Tuna Head Enzymatic Hydrolysate and Its Portions on Mouse Spleen Lymphocyte Proliferation",
        "abstract": "To investigate the effect of tuna heads enzymatic hydrolysate(EPTH)and its portions of ultrafiltration membrane with molecular weight cut-off(MWCO) of 10,5,3 and 1 kD on mouse spleen lymphocyte proliferation.The lymphocytes were prepared from spleen.The effect of EPTH and its portions on the proliferation of spleen lymphocyte in response to ConA and LPS was detected by MTT.The contents of nitrogen of EPTH and its portions were detected by micro-Kjeldadl.The portion\u2161(10-5 kD)and portion\u2164(<1 kD)significantly stimulated the mouse spleen lymphocyte proliferation with and without conA and LPS,EPTH and portion\u2160(>10 kD),\u2162(5-3 kD),\u2163(3-1 kD)had no significant stimulated or inhibited effect.The portion\u2161and portion\u2164 were rich in.stimulating factures.The protein contents of portion\u2161and portion\u2164were 38.9%,5.39% of EPTH respectively.",
        "keywords": [
            "tuna",
            "mouse",
            "enzymatic hydrolysate",
            "lymphocyte"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": ",HONG Pen-zhiKey Laboratory of Aquatic Product Advanced Processing of Guangdong Higher Education Institutes,College of Food Science & Technology,Guangdong Ocean University,Zhanjiang,"
            },
            {
                "name": "CAI Ben-li",
                "org": ",HONG Pen-zhiKey Laboratory of Aquatic Product Advanced Processing of Guangdong Higher Education Institutes,College of Food Science & Technology,Guangdong Ocean University,Zhanjiang,"
            }
        ],
        "venue": "Natural Product Research and Development",
        "year": 2010
    },
    "txDdYiWu": {
        "id": "txDdYiWu",
        "title": "NUTRITION COMPONENT OF TUNA HEAD AND APPLICATION OF ITS ENZYMOLYSIS PROTEIN",
        "abstract": "The nutrition component of yellow fin tuna head were analyzed,nutrient value of which protein was evaluated.The results showed that the content of crude protein was 68.0 % in dry basis,fat 27.2 %,abundant sodium and calcium.Nutrient value of yellow fin tuna muscle protein was evaluated by FAO/WHO essential amino acid model in 1973,which the amino acid value was 60 and the first limited amino acid was tryptophan.The protein of yellow fin tuna head was hydrolyzed by papain and flavor protease.Nutrient solution was prepared with enzymolysis protein of tuna head,in which the total nitrogen was 1.02 g/100 mL,the total content of amino acids 986.81 mg/100 mL.",
        "keywords": [
            "nutrition component",
            "yellow fin tuna",
            "enzymolysis",
            "tuna head"
        ],
        "authors": [
            {
                "name": "HONG Peng-zhi",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,Guangdong,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,Guangdong,China"
            },
            {
                "name": "ZHANG Chao-hua",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,Guangdong,China"
            },
            {
                "name": "JI Hong-wu",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,Guangdong,China"
            },
            {
                "name": "LIU Shu-cheng",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,Guangdong,China"
            },
            {
                "name": "HAO Ji-ming",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,Guangdong,China"
            },
            {
                "name": "ZHANG Jing",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,Guangdong,China"
            }
        ],
        "venue": "Food Research and Development",
        "year": 2007
    },
    "300nboYU": {
        "id": "300nboYU",
        "title": "Effect of enzymatic hydrolysis on physicochemical properties of Tilapia Skin Protein",
        "abstract": "Enzymatic proteins with good sensory properties and functional characteristics were obtained from Tilapia skin.Enzymatic proteins were prepared from Tilapia skin by Alcalase.Hydrolysis degree was controlled by pH-stat method.Effect of hydrolysis degree on the yield of enzymatic protein,solubility,emulsifying properties and sensory properties of protein power were studied.The results showed that in the range of the experiment(DH=2%~10%),the yield of hydrolyzed protein and purity protein powder increased,and solubility and emulsifying properties of hydrolyzed protein powder decreased with increased degree of hydrolysis.Sensory evaluation results showed that,for different samples,significant different fishy smell and color was observed,and insignificant bitterness was tasted.For protein powder of 2% hydrolysis degree,the highest solubility and emulsifying properties were obtained with corresponding high impurity and inferior sensory quality.Comparatively,the best sensory properties was obtained for hydrolyzed protein of 5% hydrolysis degree with heat processing before enzymatic hydrolysis.High purity hydrolyzed protein with good sensory properties and functional characteristics could be prepared by controlling of the lower hydrolysis degree(e.g.DH=5%) from Tilapia skin.",
        "keywords": [
            "sensory quality",
            "emulsifying properties",
            "Tilapia skin",
            "solubility",
            "hydrolyzed protein"
        ],
        "authors": [
            {
                "name": "QI Man",
                "org": "Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety,Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution,College of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "LAI Yong-qiang",
                "org": "Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety,Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution,College of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "ZHOU Chun-xia",
                "org": "Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety,Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution,College of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety,Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution,College of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "HONG Peng-zhi",
                "org": "Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety,Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution,College of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            }
        ],
        "venue": "Guangdong Agricultural Sciences",
        "year": 2013
    },
    "aDXbtuyO": {
        "id": "aDXbtuyO",
        "title": "Antioxidant activity and physicochemical properties of 1 ku fraction by ultrafiltration of bigeye tuna (Thunnus obesus) head protein hydrolysate",
        "abstract": "To produce bioactive peptides from the by-products of fish processing,bigeye tuna(Thunnus obesus) head was hydrolyzed by alcalase,and the tuna head protein hydrolysate(THPH) was fractionated through ultrafiltration membranes with a range of molecular weight cutoffs(MWCO) of 8,5,3 and 1 ku,respectively,to yield the fraction THPH-1 with MW distribution<1 ku.The antioxidant activities of THPH-1were evaluated using reducing power,free radical scavenging and aged model mice induced by D-galactose.The physicochemical properties of THPH-1 were analysed also.THPH-1 showed evident radical scavenging activity in a dose-dependent manner with the IC50 values for hydroxyl radical,superoxide radical and 1,1-diphenyl-2-pycrylhydrazyl(DPPH) radical being 1.38,0.73 and 0.93 mg/mL respectively.The reducing power of THPH-1 was 0.763 at 12.5 mg /mL.The activities of superoxide dismutase(SOD) of liver and the activities of glutathione peroxidase(GSH-PX) of liver and serum in aged model mice were significantly increased(P<0.05) compared with that of the normal control group mice after 42 days administrated orally at a dose of 30 mg/kg THPH-1,and the content of malondialdehyde(MDA) of serum in aged model mice was significantly decreased(P<0.01).The physicochemical properties showed that THPH-1contained 96.40% of protein(on dry basis),0.11% of fat and 4.86% of ash.The total hydrophobic amino acids content of THPH-1was 35.8% of the total amino acids content.The molecular weight distribution of the higher activity fractions of THPH-1were located at 1 802-2 519 u and 422-922 u.These results indicate that THPH-1from tuna head hydrolysate would be very fairly helpful in the preparation of antioxidative peptides and a beneficial ingredient for functional food.",
        "keywords": [
            "antioxidant activity",
            "enzymatic hydrolysate",
            "ultrafiltration",
            "fish head",
            "thunnus obesus"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "College of Food Science & Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "KE Hong-qiao",
                "org": "College of Food Science & Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "ZHANG Chao-hua",
                "org": "College of Food Science & Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "HONG Peng-zhi",
                "org": "College of Food Science & Technology,Guangdong Ocean University,Zhanjiang ,China"
            }
        ],
        "venue": "Journal of Fisheries of China",
        "year": 2012
    },
    "wfpiVn2j": {
        "id": "wfpiVn2j",
        "title": "Study on precipitating action of enzymatic hydrolysate of tilapia flesh protein by trichloroacetic acid through HPLC",
        "abstract": "In order to research the effect of TCA precipitating to proteins or peptides in the enzymatic hydrolysates of tilapia flesh,the molecular weight distributions of hydrolysates by Alcalase 2.4L and the supernatants of hydrolysates precipitating by TCA in different concentrations were studied by HPLC.The results indicated that various peptides coming from 1,2,5h hydroltsate were precipitated to varying degrees in 1%,3%,5%,7%,and 10% TCA,while 47.86%\uff5e59.28% of the >9.5ku,38.41%\uff5e65.49% of the 2.5\uff5e1.4ku,and 21.32%\uff5e78.89% of the 1.0ku removed.The precipitating percentage rised or fell with the inereasing of TCA concentrations.",
        "keywords": [
            "peptide",
            "precipitating action",
            "enzymatic hydrolysate",
            "TCA"
        ],
        "authors": [
            {
                "name": "HAN Dao-cai",
                "org": "Food Science and Technology College of Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Food Science and Technology College of Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "HONG Peng-zhi",
                "org": "Food Science and Technology College of Guangdong Ocean University,Zhanjiang ,China"
            }
        ],
        "venue": "Science and Technology of Food Industry",
        "year": 2012
    },
    "NzUCGcJe": {
        "id": "NzUCGcJe",
        "title": "EFFECT OF TEMPERATURE ON MIXOTROPHIC CULTUE OF SPIRULINA PLATENSIS BY ENZYMATIC HYDROLYSATES OF TILAPIA BYPRODUCT",
        "abstract": "In this paper the effects of temperature on mixtrophic culture of Spirulina platensis with enzymatic hydrolysates of tilapia byproduct(EHTB) were investigated.Adding 3.0(v/v) of EHTB in Zarrouk mixtrophic culture to culture S.platensis with light intensity of 230\u03bcmol/m2\u00b7s,the effects of temperature 15~40\u2103 on S.platensis biomass,chlorophyll content,phycocyanin content and protein content of the EHTB group were investigated.The results showed that comparing with the control group,the S.platensis biomass of the EHTB group significantly increased between 15~35\u2103 and at 35\u2103 the largest growth to 38.2%;the content of chlorophyll of the EHTB group significantly increased between 30~40\u2103 and at 30\u2103 the highest growth to 11.7%;the phycocyanin content of S.platensis of the EHTB group significantly increased between 15~20\u2103 and at 15\u2103 the most growth to 15.1%;the protein content of the EHTB group significantly increased between 15~35\u2103 and at 30\u2103 the most growth to13.7%.",
        "keywords": [
            "Tilapia byproducts",
            "mixotrophic culture",
            "enzymatic hydrolysate",
            "Spirulina platensis",
            "temperature"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "College of Food Science & Technology,Guangdong Ocean University, Zhanjiang ,China"
            },
            {
                "name": "SUN Jia",
                "org": "College of Food Science & Technology,Guangdong Ocean University, Zhanjiang ,China"
            },
            {
                "name": "HONG Pengzhi",
                "org": "College of Food Science & Technology,Guangdong Ocean University, Zhanjiang ,China"
            }
        ],
        "venue": "Transactions of Oceanology and Limnology",
        "year": 2012
    },
    "GecZPy4M": {
        "id": "GecZPy4M",
        "title": "Effect of Tuna Head Enzymatic Hydrolysate and Its Portions on Inmmune Function in Mice",
        "abstract": "The aim of this study was to investigate the effect of tuna heads enzymatic hydrolysate(EPTH) and its portions of ultrafiltration membrane with molecular weight cut-off(MWCO)of 10 000 and 5 000 on inmmune function in mice.In oral every day,immunity functions were measured at 14 th,19 th,32 th and 35 th day respectively.The results indicated that portion\u2161(5 000\uff5e10 000)significantly improved the thymus index,spleen index,carbon clearance index,antibody-producing cells of spleen and quantity of DNA in marrow cell of mice.Furthermore,EPTH could improved the quantity of DNA in marrow cell of mice;portion\u2160(>10 000)and portion \u2162(<5 000)could improved the spleen index.This study suggestsed portion\u2161enriched immune ingredients and could inhance immunity function in mice.",
        "keywords": [
            "mice",
            "Tuna",
            "immunity",
            "enzymatic hydrolysate"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "CAI Ben-li",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "HONG Peng-zhi",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "RAO Zi-liang",
                "org": "Guangdong Medical Laboratory Animal Centre,Nanhai ,China"
            },
            {
                "name": "ZHANG Chao-hua",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            }
        ],
        "venue": "Journal of Food Science and Biotechnology",
        "year": 2009
    },
    "1xHSggYe": {
        "id": "1xHSggYe",
        "title": "Nutrient Components and Estimation of Tuna's Back Muscle",
        "abstract": "The nutrient components of yellow fin tuna's back muscle were analyzed and its protein nutritive value was estimated.The results show that the content of crude protein of tuna's back muscle is 26.2%,the content of fat is only 0.2%.It is the healthy food of high protein,low fat.The amino acid score of protein of tuna's back muscle was 101 by essential amino acid requirement mode(adult mode) that FAO/WHO recommends in 1973.The flavor amino acids account for 41.31% of the total amount of amino acids in the back muscle and there are abundant minerals in the muscle.Therefore,tuna's back muscle is a nutritious high-quality raw material with delicious taste.",
        "keywords": [
            "Tuna",
            "Nutritional component",
            "Estimation"
        ],
        "authors": [
            {
                "name": "HONG Peng-zhi",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Guang dong ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Guang dong ,China"
            },
            {
                "name": "ZENG Shao-kui",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Guang dong ,China"
            },
            {
                "name": "ZHANG Chao-hua",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Guang dong ,China"
            }
        ],
        "venue": "Journal of Fujian Fisheries",
        "year": 2006
    },
    "bze4JTeG": {
        "id": "bze4JTeG",
        "title": "Fatty Acid Composition of Rachycentron canadum Linnaeus Head, Skin and Gut and Nutrition Value of Theirs Enzymolytic Protein Powders",
        "abstract": "The fatty acid compositions of Rachycentron canadum Linnaeus head,skin and gut were ana- lyzed and the nutrition value of their enzymolytic protein powders was evaluated.The results showed:the fatty acid compositions of crude fish oil and refined fish oil of Rachycentron canadum Linnaeus head,skin and gut are composed mainly of the 17 kinds of fatty acids of C14\uff5eC22.The content of unsaturated fatty acid was about 15% and the total content of eicosapentaenoic acid(EPA)and doconsahexaenoic acid(DHA)was about 11%.The content of crude protein in the enzymolytic protein powders was 85.46%,90.79% and 78.26%(in dry basis)respectively.The essential amino acids accounted for 27.67%,34.51% and 29.15% in total amino acids respectively,and the proportion between essential amino acids was suitable and conformed to the recommended ideal protein model of FAO/WHO.",
        "keywords": [
            "Rachycentron canadum Linnaeus",
            "nutrition value",
            "fatty acid"
        ],
        "authors": [
            {
                "name": "Yang Ping",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "Liu Shucheng",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "Zhang Jinbo",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "Ji Hongwu",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "Zhang Chaohua",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            }
        ],
        "venue": "Food and Fermentation Industries",
        "year": 2008
    },
    "VSycVX2Z": {
        "id": "VSycVX2Z",
        "title": "Study on the preparation of Pinctada martensii flavor retort porch",
        "abstract": "The process of retort pouch made from Pinctada martensii and soybean was studied.The optimized preparation conditions were:the conditions of cooking were 90\u2103 and 1min,and microwave process were 3min.Under this conditions,the products had rich nutrition,special flavor and definite health protection function.",
        "keywords": [
            "retort pouch",
            "soybean",
            "Pinctada martensii"
        ],
        "authors": [
            {
                "name": "ZHANG Jing",
                "org": "College of Food Science & Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Food Science & Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "HAO Ji-ming",
                "org": "College of Food Science & Technology,Guangdong Ocean University,Zhanjiang ,China"
            }
        ],
        "venue": "Science and Technology of Food Industry",
        "year": 2008
    },
    "zXLHv7vf": {
        "id": "zXLHv7vf",
        "title": "Fatty Acid Composition of Rachycentron canadum Linnaeus Muscle and Nutrition Evaluation of Its Enzymolytic Protein Powder",
        "abstract": "The fatty acid composition of Rachycentron canadum Linnaeus muscle was analyzed,and the nutrition value of its enzymolytic protein powder was evaluated.The results showed:the fatty acid composi- tion of crude fish oil and refined fish oil of Rachycentron canadum Linnaeus muscle have not the obvious change,mainly the 18 kinds of fatty acids of C_(14)\uff5eC_(22);the content of unsaturated fatty acid was 44.31% and 48.53% respectively;the total content of eicosapentaenoic acid (EPA) and doconsahexaenoic acid (DHA) was 13.67% and 14.88% respectively.The content of crude protein in the enzymolytic protein powder was 95.77%(in dry basis),fat 0.32% and ash 5.45%.The protein power has the characteristics of higher pro- tein substance,lower fat and abundant minerals.The essential amino acids accounted for 41.58% in total a- mino acids,the proportion between essential amino acids was suitable and conformed to the recommended i- deal protein model of FAO/WHO.",
        "keywords": [
            "Rachycentron canadum Linnaeus",
            "fatty acid",
            "nutrition evaluation"
        ],
        "authors": [
            {
                "name": "Hong Pengzhi",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "Yang Ping",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "Liu Shucheng",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "Ji Hongwu",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "Zhang Chaohua",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            }
        ],
        "venue": "Food and Fermentation Industries",
        "year": 2007
    },
    "Npo6YOfQ": {
        "id": "Npo6YOfQ",
        "title": "Optimization of technology for preparation of angiotensin-I-converting enzyme inhibitory peptides by hydrolyzing the head of cobia with papain",
        "abstract": "The technology for preparation of angiotensin-I-converting enzyme inhibitory peptides by hydrolyzing heads of cobia with papain was optimized by using the index of the Angiotensin-I-Converting Enzyme(ACE) inhibitory activity.The peptides with high ACE inhibitory activities were selected.Experimental results indicated that the peptides with optimum ACE inhibitory activity were obtained when the enzymic hydrolysis parameters are composed of 73\u2103,pH 6.0 and enzyme dosage 2300 U/g,ratio of matieral to water was one to two,hydrolysis time was four hours.In those conditions,the ACE inhibitory activity was the maximum with 82.63% and the degree of hydrolysis was 17.21%.",
        "keywords": [
            "enzymic hydrolysis",
            "inhibitory peptides of angiotensin converting enzyme(ACE)",
            "response surface",
            "heads of cobia"
        ],
        "authors": [
            {
                "name": "JIANG Yu-chuan",
                "org": "College of Food Seience and Technology,Guangdong Ocean University,Zhanjiang "
            },
            {
                "name": "HONG Peng-zhi",
                "org": "College of Food Seience and Technology,Guangdong Ocean University,Zhanjiang "
            },
            {
                "name": "YANG Ping",
                "org": "College of Food Seience and Technology,Guangdong Ocean University,Zhanjiang "
            }
        ],
        "venue": "Food Science and Technology",
        "year": 2010
    },
    "yWTYyDCa": {
        "id": "yWTYyDCa",
        "title": "Study on Preparation of Multiple-enzyme Hydrolysate of Tilapia Scraps Chelating with Zinc",
        "abstract": "The composite enzymatic hydrolysis conditions of neutral protease and flavourzyme were optimized by orthogonal test,the ultrafiltration of hydrolysate from tilapia scraps was done to compare chelating activity,and chelating salt was identified by UV-Visible Spectrophotometer and Fourier Transform Infrared Spectrometer.The results showed that the optimal conditions were temperature 55\u2103,enzyme concentration 1500 U / g,composite ratio 1 \u2236 2,solid-liquid ratio1 \u2236 4,natural pH.The chelation rate of enzymatic hydrolysate reached 77.92%,hydrolysis degree was 14.43%.Among these ultrafiltrate fractions of the hydrolysate,the components,which molecular weight were less than 10KDa,showed the highest zinc-binding capacity,the chelation rate as high as 89.36%,while the fractions below 1KDa had a relatively lower rate of 61.45%.",
        "keywords": [
            "Tilapia scraps",
            "chelation",
            "ultrafiltration",
            "enzymolysis"
        ],
        "authors": [
            {
                "name": "LI Tong-gang",
                "org": "College of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "CHEN Kang-jian",
                "org": "Zhanjiang Hengrun Aquatic Co.Ltd.,Zhanjiang ,China"
            },
            {
                "name": "HONG Peng-zhi",
                "org": "College of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            }
        ],
        "venue": "Packaging and Food Machinery",
        "year": 2013
    },
    "ArMOu1Jg": {
        "id": "ArMOu1Jg",
        "title": "Effect of Protein Hydrolysates from Tilapia Byproduct on Growth in Alga Spirulina platensis",
        "abstract": "The protein hydrolysates of tilapia byproduct(PHTB) were added to the mixtrophic culture medium of alga Spirulina platensis at different rates to evaluate the effects of the PHTB on the biomass,levels of chlorophyll a,and phycocyanin,and nitratase metabolism of the alga.There were 40.4% higher biomass,35.4% higher chlorophyll a level,higher nitratase activity(NRA)and buffer effect in the group at addition of 3.0 PHTB than those in the control.However,no significant effect of the PHTB supplementation was found in the experiment.",
        "keywords": [
            "hydrolysate of tilapia byproduct",
            "mixotrophic culture",
            "Spirulina platensis"
        ],
        "authors": [
            {
                "name": "SUN Jia",
                "org": "Key Laboratory of Aquatic Product Advanced Processing of Guangdong Higher Education Institutes,College of Food Science & Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "HONG Peng-zhi",
                "org": "Key Laboratory of Aquatic Product Advanced Processing of Guangdong Higher Education Institutes,College of Food Science & Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Key Laboratory of Aquatic Product Advanced Processing of Guangdong Higher Education Institutes,College of Food Science & Technology,Guangdong Ocean University,Zhanjiang ,China"
            }
        ],
        "venue": "Fisheries Science",
        "year": 2010
    },
    "Gvn29xNL": {
        "id": "Gvn29xNL",
        "title": "Study on food nutrient contents and preparation of nutrient liquid of swim bladder in Muraenesox cinereus",
        "abstract": "The food nutrient compositions were analyzed in the swim bladder of Muraenesox cinereus and its nutrient liquid was prepared with the swim bladder.The results indicated that the content of protein was 24.63% and flavor development amino acids such as Glu,Asp,Ala and Gly accounted for 52.5% of all amino acids,of which the content of Gly accounted for 23.4%.The content of vitamin E was high up to 1.52 mg/100g and the content of Ca was 13.25 mg/100g.Other minerals such as Zn and Fe were rich too.After being extracted at a low temperature as 65 \u2103,the swim bladder gel was prepared.The result of orthogonal experiment indicated the optimum proportion of nutrient liquid of the swim bladder was that 100 g gel mixed with 75 g extraction from Chinese medicine and 4 mL yellow wine and 15 g rock candy.The content of protein in nutrient liquid was as high as 5.87% and its colour and flavour were good.",
        "keywords": [
            "Muraenesox cinereus",
            "nutrient liquid",
            "nutrient compositions",
            "swim bladder"
        ],
        "authors": [
            {
                "name": "ZENG Shao-kui",
                "org": "Sea Food Safety Laboratory,Ocean University of China,Qingdao ,China;College of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "LIN Hong",
                "org": "Sea Food Safety Laboratory,Ocean University of China,Qingdao ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "ZHANG Chao-hua",
                "org": "College of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            }
        ],
        "venue": "Journal of Shanghai Fisheries University",
        "year": 2006
    },
    "tTx5O2UU": {
        "id": "tTx5O2UU",
        "title": "Enzymatic Hydrolysis of Protein from Tilapia Scraps Using Papain",
        "abstract": "The optimal hydrolysis conditions of tilapia scraps were studied by papain.The results indicated that the optimum hydrolysis were found under the following conditions:a rafio of tilapia wastes to water being 1 \u22361.5,initial pH,60 \u2103,1100 IU/g raw material,and 3 h period.Under the optimal conditions,the content of amino acid nitrogen was 1.25 g/L and the content of protein was 5.19% in hydrolysis solution,and the recovery rate of nitrogen was 69.88%.The concentration of enzyme was one of the main factors controlling the hydrolysis rate.",
        "keywords": [
            "hydrolysis",
            "Tilapia scrap",
            "papain"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "XIA Yong-jun",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "FAN Wei-qun",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            }
        ],
        "venue": "Fisheries Science",
        "year": 2008
    },
    "xHtBTkVT": {
        "id": "xHtBTkVT",
        "title": "Isolation and Properties of Salt-soluble Protein from Tilapia Muscle",
        "abstract": "Salt soluble protein was separated using chemical method from Tilapia meat in this study,and thermal stability and pH stability were determined.Study of the thermal stability of salt soluble protein showed that,the rates of protein thermal denaturation and aggregation were significantly increased with the increase of heating time and heating temperature.Within the temperature of 40 \u2103,heating treatment for 30 min showed little effect on the turbidity of protein system.When the temperature increased,the salt concentration showed significant effect on the denaturation rate of salt soluble protein.The aggregation rate of the salt-soluble protein in 0.3 mol/L KCl was 6.8 times higher than that in 0.6 mol/L KCl at 50 \u2103.The pH stability of salt soluble protein analysis showed that the pH-shifting treatment from pH 3.0 to 7.0 and from 4.0 to 7.0 reduced the solubility of salt soluble protein,the content of active thiol,the emulsifying properties and the stability of salt soluble protein extracted by low concentration of salt.The pH-shifting treatment from pH 9.0 to 7.0 and from 11.0 to 7.0 increased the solubility of salt soluble protein,while the content of activity sulfhydryl did not change significantly.Therefore,the stability of salt soluble protein was higher at alkali condition.However,both the acid and alkali adjustment reduced the Ca2+-ATPase activity of salt soluble protein significantly and increased the relative surface hydrophobicity of protein molecules.Besides,the desalination of salt soluble proteins resulted in loss of Ca2+-ATPase activity,and the stability of the protein was significantly worse.",
        "keywords": [
            "thermal stability",
            "salt-soluble protein",
            "stability",
            "tilapia"
        ],
        "authors": [
            {
                "name": "TANG Xiao-dan",
                "org": "College of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "ZHOU Chun-xia",
                "org": "College of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "HONG Peng-zhi",
                "org": "College of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            }
        ],
        "venue": "Modern Food Science and Technology",
        "year": 2011
    },
    "8YCmux9n": {
        "id": "8YCmux9n",
        "title": "Effect of Enzyme Hydrolyzed Protein of Tuna Head on Immune Function of Mice",
        "abstract": "Tuna heads were enzyme hydrolyzed for the mixture containing much protein(EPTH),and EPTH was ingested to mice whose immunity function was depressed by Cyclophosphamide(CY).And then,the spleen indexes,thymus indexes and peritoneal macrophage phagocytosis in mice were analyzed,the proliferation of mice splenolymphocytes activated with Con A was measured,and the number of antibody forming cells was comprehensively observed.The results indicated that the phagocytosis and the indexes of thymus and spleen in immune-impressed mice were improved greatly after treatment with EPTH.The proliferation of mice splenolymphocytes activated with ConA was increased markedly,and the number of cells forming antibody was also increased significantly.These experiments showed that EPTH had a remarkable improving effect on nonspecific and specific immune function inhibited by CY in mice.",
        "keywords": [
            "mice",
            "tuna",
            "enzyme hydrolyzed protein",
            "immunity"
        ],
        "authors": [
            {
                "name": "CAI Ben-li",
                "org": "The Food Science & Technology College,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "HONG Peng-zhi",
                "org": "The Food Science & Technology College,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "YANG Ping",
                "org": "The Food Science & Technology College,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "RAO Zi-liang",
                "org": "Guangdong Medical Laboratory Animal Center,Nanhai ,China"
            }
        ],
        "venue": "Natural Product Research and Development",
        "year": 2007
    },
    "CxGFokJj": {
        "id": "CxGFokJj",
        "title": "Preparation of High Peptide Content Hydrolysate from Tilapia by Uniform Design",
        "abstract": "Neutral protease was chosen the best for obtaining high peptide content tilapia flesh hydrolysate from pepsin,trypsin,Alcalase2.4 L,neutral protease and papain,while the degree of hydrolysis and peptide content as the indicators.Based on the results of single-factor experiments,the uniform design experiment had been done to optimize the enzymatic conditions of neutral protease.The optimum conditions for peptide content were that the enzyme quantity 1.38 %,the solid-liquid ratio 1\u22363(g/mL),the temperature 50 \u2103,the inherent pH and the time 7 h.And the peptide content was(37.71\u00b10.11)mg(per gram fish flesh) at the optimum conditions.",
        "keywords": [
            "uniform design",
            "enzymatic hydrolysis",
            "degree of hydrolysis",
            "peptide content",
            "tilapia"
        ],
        "authors": [
            {
                "name": "HAN Dao-cai",
                "org": "Food Science and Technology College,Guangdong Dong Ocean University,Zhanjiang ,Guangdong,China;Key Laboratory of Guangdong Higher Education Institutions for Advanced Processing of Aquatic Product,Zhanjiang ,Guangdong,China"
            },
            {
                "name": "HONG Peng-zhi",
                "org": "Food Science and Technology College,Guangdong Dong Ocean University,Zhanjiang ,Guangdong,China;Key Laboratory of Guangdong Higher Education Institutions for Advanced Processing of Aquatic Product,Zhanjiang ,Guangdong,China"
            },
            {
                "name": "YANG Ping",
                "org": "Food Science and Technology College,Guangdong Dong Ocean University,Zhanjiang ,Guangdong,China;Key Laboratory of Guangdong Higher Education Institutions for Advanced Processing of Aquatic Product,Zhanjiang ,Guangdong,China"
            }
        ],
        "venue": "Food Research and Development",
        "year": 2012
    },
    "tttnVFkB": {
        "id": "tttnVFkB",
        "title": "Study on effect of microporous filter on Tilapia wastes protein hydrolysates",
        "abstract": "Using the microporous filters of 0.45\u03bcm and 0.22\u03bcm to filter the Tilapia wastes papain protein hydrolysates,the properties and thermostability between original fluid and two filtrates was compared.The result indicated that microporous membrane filters were good for clarifying,deodorizing and the thermostability of Tilapia wastes protein hydrolysates.With the aperture reduced,the effect enhanced.The contents of protein a little reduced because of microporous membrant filters.The protein contents of filtering medium of the microporous filtration of 0.45\u03bcm and 0.22\u03bcm reduced 3.12% and 10.42%.The microporous membrane had no effect on the moisture,ash,alpha-amino nitrogen,trichloroacetic acid dissoluble protein and pH.",
        "keywords": [
            "enzymatic hydrolysis",
            "microporous membrane",
            "Tilapia wastes",
            "deodorizing",
            "clarifying"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "HONG Peng-zhi",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "CHEN Dan",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            }
        ],
        "venue": "Science and Technology of Food Industry",
        "year": 2008
    },
    "FPx2aiWp": {
        "id": "FPx2aiWp",
        "title": "Evaluation of protein nutritional value in different tissues of cobia",
        "abstract": "The basic nutrient composition in the different tissues of cobia was determined by food analysis method and the nutritional value of their protein was evaluated.The results showed that cobia was rich in protein and fats,the protein nutritional value of back muscles and abdominal muscle from cobia was higher than that of head,skin and visceral,the ratio of BCAA/AAA in the different tissues of cobia ranged from 2.4~2.6,which was close to the body's normal level,and the total flavor amino acid of cobia muscle accounted for 38%~ 40% in the total amino acids.",
        "keywords": [
            "cobia",
            "essential amino acids",
            "protein",
            "nutritional value"
        ],
        "authors": [
            {
                "name": "LIU Shu-cheng",
                "org": "College of Food Science and Technology,Guangdong Ocean University,Zhanjiang "
            },
            {
                "name": "LI De-tao",
                "org": "College of Food Science and Technology,Guangdong Ocean University,Zhanjiang "
            },
            {
                "name": "HONG Peng-zhi",
                "org": "College of Food Science and Technology,Guangdong Ocean University,Zhanjiang "
            },
            {
                "name": "ZHANG Chao-hua",
                "org": "College of Food Science and Technology,Guangdong Ocean University,Zhanjiang "
            },
            {
                "name": "YANG Ping",
                "org": "College of Food Science and Technology,Guangdong Ocean University,Zhanjiang "
            },
            {
                "name": "JI Hong-wu",
                "org": "College of Food Science and Technology,Guangdong Ocean University,Zhanjiang "
            }
        ],
        "venue": "Food Science and Technology",
        "year": 2010
    },
    "hzQ8zuS6": {
        "id": "hzQ8zuS6",
        "title": "Study on Adsorption of Congo Red in Water on Calcined Oyster Shell Powder",
        "abstract": "Adsorption characteristic of Congo red on calcined oyster shell powder was studied.The results indicated that the adsorption equilibrium time of oyster shell powder for Congo red was 6h;0.5g\u00b7L-1 of oyster shell powder could remove 96.0% of the dye from 70 mg\u00b7L-1Congo red and unit adsorption capacity of oyster shell powder was 137.81 mg\u00b7g-1.Adsorption velocity increased with the temperature raised but equilibrium adsorption rate somewhat less effective.According to the adsorption isotherm curves of Congo red on oyster shell powder,the regularity of adsorption fit Henry isothermal adsorption.",
        "keywords": [
            "absorption",
            "Congo red",
            "calcinied oyster shell"
        ],
        "authors": [
            {
                "name": "ZOU Qiu-yue",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "WANG Yan",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            },
            {
                "name": "JIA Lei",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang ,China"
            }
        ],
        "venue": "Technology & Development of Chemical Industry",
        "year": 2010
    },
    "s9Y6Ah2a": {
        "id": "s9Y6Ah2a",
        "title": "Effect of enzymatic hydrolyzed animal protein extracted from pinctada martensii and taurine on brain monoamine neurotransmitters of exhausted mice",
        "abstract": "Objective:To observe the effect of EAP and taurine on brain monoanime neurotransmitters of exhausted mice.Method:The mice were devided into five groups at random,they are control group,EAP group,Tau1 group,Tau2 group and Tau3 group.The DA and 5-HT detection is fluorescence method.Results:After exhausted swimming the contents of DA and 5-HT of EAP,Tau1,Tau2 and Tau3 group were higher dramatically than control group.The value of DA/5-HT of group of EAP,Tau1 and Tau2 is higher than control group.Conclusion:EAP and taurine have all effect on resistance of fatigue of central nervous system,the effect of taurine shows dose effect relationship.",
        "keywords": [
            "neurotransmitter",
            "anti-fatigue",
            "taurine",
            "enzyme hydrolyzed protein"
        ],
        "authors": [
            {
                "name": "LIU Ya",
                "org": "School of Food Science and technology,Guangdong Ocean University,Zhanjiang "
            },
            {
                "name": "ZHANG Chao-hua",
                "org": "School of Food Science and technology,Guangdong Ocean University,Zhanjiang "
            },
            {
                "name": "YANG Ping",
                "org": "School of Food Science and technology,Guangdong Ocean University,Zhanjiang "
            },
            {
                "name": "HAO Ji-ming",
                "org": "School of Food Science and technology,Guangdong Ocean University,Zhanjiang "
            },
            {
                "name": "ZHANG Jing",
                "org": "School of Food Science and technology,Guangdong Ocean University,Zhanjiang "
            }
        ],
        "venue": "Food Science and Technology",
        "year": 2010
    },
    "gGTiDD0z": {
        "id": "gGTiDD0z",
        "title": "Study on preparation of vegetables paste can by enzymatic hydrolysates from tilapia byproduct",
        "abstract": "In this paper the basic formula and technology of vegetables paste canning with tilapia byproduct protein enzymatic hydrolysates were studied.By organoleptic examination and mathematical analysis,we obtained the formula as follows: the tilapia byproduct protein enzymatic hydrolysates was added 20%,carrot 50%,pumpkin 30%,onion 5%,whole milk powder 3%,sugar 6% and salt 1%.The product contained water 85.57%,protein 2.88%,fat 1.24% and suger 4.7%.The product is orange yellow sauce with unique taste,exquisite mounts moderately center and good emulsified effect.",
        "keywords": [
            "can",
            "vegetables",
            "protein enzymatic hydrolysate",
            "tilapia byproduct"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang "
            },
            {
                "name": "HONG Peng-zhi",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang "
            },
            {
                "name": "ZHUO Xiao-juan",
                "org": "School of Food Science and Technology,Guangdong Ocean University,Zhanjiang "
            }
        ],
        "venue": "Food Science and Technology",
        "year": 2008
    },
    "bnXCDGz0": {
        "id": "bnXCDGz0",
        "title": "Study on enzymatic hydrolysis to protein from yellow fin tuna head",
        "abstract": "The optimal catalyzed-hydrolysis conditions of the yellow fin tuna head were obtained by adding the bi-enzyme between papain, neutral protease and flavor protease. Some factors, such as the concentration of protease, hydrolysis temperature, hydrolysis time, affected catalyzed-hydrolysis condition, were studied by the orthogonal experiment. The results indicated that the effect of hydrolysis was the best by adding papain and neutral protease simultaneously. Under the optimal conditions, the content of amino acid nitrogen was 126.53mg/100mL in hydrolysis solution, the recovery rate of nitrogen was 80.2%, the total content of amino acid was 4.12mg/100mL, the essential amino acid accounted for 36.04% in amino acid and the free amino acid was 0.81g/100mL.",
        "keywords": [
            "emzymolysis",
            "thunnus obesu",
            "protease"
        ],
        "authors": [
            {
                "name": "HONG Peng-zhi",
                "org": "School of Food Science and Technology, Guangdong Ocean University, Zhanjiang "
            },
            {
                "name": "YANG Ping",
                "org": "School of Food Science and Technology, Guangdong Ocean University, Zhanjiang "
            },
            {
                "name": "ZENG Shao-kui",
                "org": "School of Food Science and Technology, Guangdong Ocean University, Zhanjiang "
            },
            {
                "name": "JI Hong-wu",
                "org": "School of Food Science and Technology, Guangdong Ocean University, Zhanjiang "
            },
            {
                "name": "LIU Shu-cheng",
                "org": "School of Food Science and Technology, Guangdong Ocean University, Zhanjiang "
            },
            {
                "name": "ZHANG Chao-hua",
                "org": "School of Food Science and Technology, Guangdong Ocean University, Zhanjiang "
            }
        ],
        "venue": "Food Science and Technology",
        "year": 2007
    },
    "MHCx333Z": {
        "id": "MHCx333Z",
        "title": "Investigation on quality of life status of breast cancer patients after operation in follow-up period",
        "abstract": "Objective:To know the quality of life(QOL) state of breast cancer patients in follow-up period and to analyze the related factors of influencing QOL.Methods:A total of 97 female breast cancer survivors in follow-up finished chemotherapy and radiotherapy were investigated by filling out questionnaire of Chinese version EORTC QLQ-C30 and the EORTC QLQ-BR23.And SPSS was used for data analysis.Result:The overall QOL score of all 97 breast cancer patients was 71.31.The lowest score of functioning in QLQ-C30 was emotional functioning,and the highest score was financial difficulties.In the QLQ-RR23,the lowest score of functioning was sexual functioning and the highest score was systemic therapy side effects.Related factors influencing the overall quality of life of breast cancer patients included method of operation,recovery of ill limb function and if patient had a job or not.Conclusion:Postoperative breast cancer patients in follow-up period have a relatively good QOL.Functions of all aspects of patients had improved and all kinds of symptoms of them had abated.Medical staffs should pay attention to sexual function of these breast cancer survivors.It suggested that breast-conserving therapy,function recovery of affected extremities,and having a job may improve QOL of breast cancer patients in follow-up period.",
        "keywords": [
            "breast cancer",
            "influencing factor",
            "follow-up period",
            "quality of life"
        ],
        "authors": [
            {
                "name": "Yang Ping",
                "org": "Nursing College of Beijing University,Beijing  China"
            },
            {
                "name": "Pang Dong",
                "org": "Nursing College of Beijing University,Beijing  China"
            },
            {
                "name": "Lu Qian",
                "org": "Nursing College of Beijing University,Beijing  China"
            }
        ],
        "venue": "Chinese Nursing Research",
        "year": 2009
    },
    "Gnhgzid1": {
        "id": "Gnhgzid1",
        "title": "Study on depression and rehabilitation status in the old patients with hip fracture after operation",
        "abstract": "Objective To investigate the depression status in old patients with hip fracture after operation and explore the relationship among depression,rehabilitation status and quality of life.Methods Seventy-one post operative old patients with hip fracture were recruited from a 3A-level hospital in Beijing.Geriatric Depression Scale(GDS) was used to investigate the levels of depression of the patients,Barthel Index and Harris Hip Joint Function Scale were used to assess the current physical rehabilitation status of the patients,Short Form 36 Health Survey Questionnaire(SF-36) was used to assess the quality of life of the patients.Results The incidence of depression among postoperative old patients with hip fracture was 39.44%.The old patients were divided into 2 groups with or without depression,compared the Barthel index,Harris score and SF-36 scores(with the exception of somaticpain and emotional functions) in two groups and found depression group had lower scores than the other group(P<0.01 or P<0.05).Conclusion The occurrence of depression in the postoperative old people with hip fracture is high.Depression has a negative effect on rehabilitation status of patients.",
        "keywords": [
            "hip fracture",
            "postoperation",
            "depression",
            "old people",
            "rehabilitation"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "School of Nursing,Peking University,Beijing ,China"
            },
            {
                "name": "LU Qian",
                "org": "School of Nursing,Peking University,Beijing ,China"
            },
            {
                "name": "WANG Xiao-dan",
                "org": "School of Nursing,Peking University,Beijing ,China"
            },
            {
                "name": "PANG Dong",
                "org": "School of Nursing,Peking University,Beijing ,China"
            },
            {
                "name": "JIN San-li",
                "org": "School of Nursing,Peking University,Beijing ,China"
            },
            {
                "name": "WANG Su-zhen",
                "org": "Department of Orthopedicas,Beijing Jishuitan Hospital,Beijing ,China"
            }
        ],
        "venue": "Journal of Nursing Administration",
        "year": 2012
    },
    "8TpRnfm3": {
        "id": "8TpRnfm3",
        "title": "The effect of cancer-related fatigue on the quality of life in breast cancer patients undergoing chemotherapy",
        "abstract": "Objectives To explore the status of cancer-related fatigue and quality of life in breast cancer patients receiving chemotherapy and analyze the influence of cancer-related fatigue on quality of life.Methods Ninety-eight breast cancer patients were recruited in this study.Data regarding the cancer-related fatigue and quality of life in breast cancer patients were collected by RPFS-C(Revised Piper Fatigue Scale-Chinese Version) and SF-36(Short Form 36) Health Survey Questionnaire.Results The prevalence of cancer-related fatigue of breast cancer patients receiving chemotherapy was 64.29%,including 30.61% moderate degree.The 7 subscales(Physical Functioning,Role-Physical,Bodily Pain,General Health,Vitality,Social Functioning,Role-Emotional) scores of SF-36 in breast cancer patients receiving chemotherapy were lower than those of domestic normal people (P<0.01).Liner regression analysis showed that age,the scores of RPFS and behavioral/severity,cognitive/mood,affective meaning had significant effects on 7 subscales scores except General Health of SF-36(P<0.01).Conclusions The quality of life in breast cancer patients receiving chemotherapy is worse than domestic normal people.Age and cancer-related fatigue are the main factors affecting quality of life in breast cancer patients.",
        "keywords": [
            "breast cancer",
            "cancer-related fatigue",
            "quality of life",
            "chemotherapy"
        ],
        "authors": [
            {
                "name": "YU Xin-ying",
                "org": "Breast Center,Peking Universtiy School of Oncology,Beijing Cancer Hospital Beijng Institute Cancer Reserch,Beijing ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Nursing,Peking University,Beijing ,China"
            },
            {
                "name": "SUN Hong-juan",
                "org": "Breast Center,Peking Universtiy School of Oncology,Beijing Cancer Hospital Beijng Institute Cancer Reserch,Beijing ,China"
            },
            {
                "name": "OUYANG Tao",
                "org": "Breast Center,Peking Universtiy School of Oncology,Beijing Cancer Hospital Beijng Institute Cancer Reserch,Beijing ,China"
            },
            {
                "name": "ZHANG Ling",
                "org": "Breast Center,Peking Universtiy School of Oncology,Beijing Cancer Hospital Beijng Institute Cancer Reserch,Beijing ,China"
            },
            {
                "name": "DING Yue",
                "org": "Nursing Department,Peking Universtiy School of Oncology Beijing Cancer Hospital Beijng Institute Cancer Reserch,Beijing ,China"
            }
        ],
        "venue": "Journal of Nursing Administration",
        "year": 2010
    },
    "esERpcQG": {
        "id": "esERpcQG",
        "title": "Investigation of the diet and nutritional status of gastric cancer patients after radical gastrectomy",
        "abstract": "Objective To investigate the diet and nutritional status of gastric cancer patients during the early postoperative period after radical gastrectomy,so as to provide references for clinical nutritional nursing. Methods Seventy gastric cancer patients undergoing radical gastrectomy were recruited and investigated about their diet and nutritional status at admission,discharge and 4 to 6 weeks after surgery. Dietary guidance received by patients at discharge and problems encountered in diet recovery process were also recorded. Results Obvious diet changes were observed among gastric cancer patients after surgery. Daily food intake decreased at admission,discharge and 4 to 6 weeks after surgery,more decreased after surgery. The patients' body weigh( BW),body mass index( BMI),arm circumference( AC),arm muscle circumference( AMC),albumin( ALB) were significantly lower than what were at admission( P < 0. 05). The patients' BW,BMI,triceps skin fold thickness( TSF),AC and albumin 4 to 6 weeks after surgery were lower than what were at discharge( P < 0. 05). The patients' BW,BMI,TSF,AC and AMC 4 to 6 weeks after surgery were lower than what were at admission( P < 0. 05). The instructions patients got were insufficient.Conclusion The postoperative intake of gastric cancer patients is insufficient,and their nutritional status continues deteriorating. It is suggested to perfect the contents and methods of dietary guidance and provide out- of- hospital dietary guidance when necessary.",
        "keywords": [
            "gastric cancer",
            "diet",
            "nutritional status"
        ],
        "authors": [
            {
                "name": "YING Sheng-yan",
                "org": ""
            },
            {
                "name": "LU Qian",
                "org": ""
            },
            {
                "name": "REN Hui",
                "org": ""
            },
            {
                "name": "PANG Dong",
                "org": ""
            },
            {
                "name": "YANG Ping",
                "org": ""
            },
            {
                "name": "JIN San-li",
                "org": ""
            }
        ],
        "venue": "Journal of Nursing Administration",
        "year": 2013
    },
    "kiJfgK8n": {
        "id": "kiJfgK8n",
        "title": "The status and related factors of the sleep quality in continuous ambulatory peritoneal dialysis patients",
        "abstract": "Objective To investigate the sleep quality of patients with Continuous Ambulatory Peritoneal Dialysis(CAPD)and analyze its related factors.Methods A total of 117 CAPD patients were investigated with Pittsburgh Sleep Quality Index(PSQI),International Physical Activity Questionnaire(IPAQ)and Subject Global Assessment(SGA).Results The PSQI score of 117 patients was 7.45\u00b14.58.Fifty-two patients(44.44%)were \"well sleepers\"(PSQI\u22645),65 patients(55.56%)were \"poor sleepers\"(PSQI>5),of which 33 patients(28.21%)were \"the poorest sleepers\"(PSQI>10).The sleep latency was significantly different between male and female patients(P<0.05).Patients with different SGA scores were significantly different in sleep latency and use of sleep medication(P<0.05).Correlation analysis showed that the level of serum albumin had negative correlations with the score of sleep efficiency and sleep disturbance factors,and the energy expenditure of daily physical activity had negative correlations with sleep disturbance and the tota score of PSQI(P<0.05).Conclusion Sleep complaints are very common in CAPD patients.The gender,nutritional status,physical activity may be associated with the quality of sleep.",
        "keywords": [
            "related factor",
            "continuous ambulatory peritoneal dialysis",
            "quality of sleep"
        ],
        "authors": [
            {
                "name": "GENG Yan",
                "org": "Department of Nephrology,Peking University Third Hospital,Beijing ,China;School of Nursing,Peking University,Beijing ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Nursing,Peking University,Beijing ,China"
            },
            {
                "name": "LU Qian",
                "org": "School of Nursing,Peking University,Beijing ,China"
            },
            {
                "name": "SU Chun-yan",
                "org": "Department of Nephrology,Peking University Third Hospital,Beijing ,China"
            },
            {
                "name": "WANG Tao",
                "org": "Department of Nephrology,Peking University Third Hospital,Beijing ,China"
            }
        ],
        "venue": "Journal of Nursing Administration",
        "year": 2010
    },
    "1YhXhHKS": {
        "id": "1YhXhHKS",
        "title": "Study on the framwork of role functions among oncology advanced practice nurses",
        "abstract": "Objective To explore the framework of role functions among oncology advanced practice nurses(OAPN).Methods The experts consultation questionnaire was developed on the basis of literature review and semi-structured interview,and refered to the comment of experts coordination groups.Forty-six experts with the backgrounds of hospital management,clinical nursing,medicine,and nursing education were enrolled from ten provinces or cities in China.The final results were obtained after three rounds of consultation.Results There were totally 5 first level indicators and 41 secondary level indicators.The five first level indicators of role functions of OAPN include five aspects,which were clinical practitioner,educator and consultant,coordinator,researcher,and manager.Conclusion Identifying the role functions of OAPN can provide theoretical basis for the selection,training,and evaluation of OAPN.",
        "keywords": [
            "Delphi method",
            "oncology",
            "advanced practice nurse",
            "role function"
        ],
        "authors": [
            {
                "name": "ZHAO Yi-yuan",
                "org": "Nursing Department,Peking University Cancer Hospital,Beijing ,China"
            },
            {
                "name": "DING Yue",
                "org": "Nursing Department,Peking University Cancer Hospital,Beijing ,China"
            },
            {
                "name": "PANG Dong",
                "org": "School of Nursing,Peking University,Beijing ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Nursing,Peking University,Beijing ,China"
            },
            {
                "name": "JIN San-li",
                "org": "School of Nursing,Peking University,Beijing ,China"
            },
            {
                "name": "LU Qian",
                "org": "School of Nursing,Peking University,Beijing ,China"
            }
        ],
        "venue": "Journal of Nursing Administration",
        "year": 2011
    },
    "PZVq9R0M": {
        "id": "PZVq9R0M",
        "title": "Study on the comfortable and safety degree by instruction of early ambulation for patients after the percutaneous Renal Biopsy",
        "abstract": "Objective To study the comfort and safety degree for patients with early ambulation after Percutaneous renal biopsy.Methods Observing and questionnaire methods were employed.Early ambulation group was contrasted to routine group,effect on comfort and safety degree for patients who start ambulation early about the pain and complication after the Percutaneous renal biopsy were observed and compared.Results There was no significant difference on complication between test group and control group(P>0.05).There were significant difference between test group and control group in degree and intension of the pain(P<0.05) and sleep(P<0.01)after the Percutaneous renal biopsy. The PRI of the test group was lower than the control group.Conclusion Early ambulation after the Percutaneous renal biopsy couldn't increase the risk of the complication and would be propitious to increase the comfortable degree of patients.",
        "keywords": [
            "Renal biopsy Complication Comfort degree Early ambulation Nursing"
        ],
        "authors": [
            {
                "name": "Li Xiangping",
                "org": "Nursing School of Beijing University,Beijing "
            },
            {
                "name": "Yang Wenjing",
                "org": "Nursing School of Beijing University,Beijing "
            },
            {
                "name": "Wang Lijuan",
                "org": "Nursing School of Beijing University,Beijing "
            },
            {
                "name": "ping Yang",
                "org": "Nursing School of Beijing University,Beijing "
            }
        ],
        "venue": "Journal of Nurses Training",
        "year": 2006
    },
    "X3jelgdI": {
        "id": "X3jelgdI",
        "title": "Analysis of risk profile and related factors of deep-vein thrombosis in lower limbs of cancer inpatients",
        "abstract": "Objective To predict the risk of deep-vein thrombosis(DVT) in lower limbs of cancer inpatients and to analyze the related factors.Methods A total of 477 cancer inpatients were recruited and assessed by Wells Scale combined with D-dimer test.Patients with Wells score one point and positive D-dimer test,or Wells score over two points were examined by both lower limbs Color Doppler examination.Factors related with DVT were analyzed.Results A total of 44 cancer inpatients were occurred DVT in 477 cases,the incidence of DVT was 9.22%.Lying in bed over 3 days and smoking history were risk factors of DVT in cancer inpatients.Conclusion More attention should be paid to cancer inpatients with lying in bed over 3 days and smoking history in case of DVT.",
        "keywords": [
            "deep-vein thrombosis(DVT)",
            "risk profile",
            "cancer"
        ],
        "authors": [
            {
                "name": "GU Bing-hong",
                "org": ""
            },
            {
                "name": "YANG Ping",
                "org": "School of Nursing,Peking University,Beijing ,China"
            }
        ],
        "venue": "Journal of Nursing Administration",
        "year": 2013
    },
    "2fGChpgK": {
        "id": "2fGChpgK",
        "title": "Numerical analysis of temperature field during liquid nitrogen freezing in high-confined aquifer reinforcement",
        "abstract": "In order to solve the problems of how to replace the water,the shield tail brushes and so on.With Qingchun Road cross-river tunnel of Hangzhou as an example,this paper applies ADINA finite element calculation software to compute thermal field for liquid nitrogen freezing 3-D model,studies thermal spatial distribution and the variation laws of temperature with time,and does the sensitivity analysis for influence factors of freezing temperature field.Through the contrast analysis of numerical simulation and field measurement,we get the development regularity of nitrogen freezing temperature field: liquid nitrogen freezing time is shorter along with the increase of thermal conductivity and slowly longer along with heat capacity;the liquid nitrogen freezing temperature is lower,the time of freezing is shorter,which solve the problem of shield brushes tail replacement in high-confined aquifer.",
        "keywords": [
            "temperature field",
            "liquid nitrogen freezing",
            "frozen soil wall",
            "numerical analysis",
            "shield tail",
            "confined aquifer"
        ],
        "authors": [
            {
                "name": "CHEN Cheng",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "ZHANG Ting",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            }
        ],
        "venue": "Journal of Nanjing Forestry University(Natural Sciences Edition)",
        "year": 2012
    },
    "HOXaQeib": {
        "id": "HOXaQeib",
        "title": "Influence of porosity and saturation on thermal properties of silty soils",
        "abstract": "In order to study the influence of porosity and saturation on thermal properties of silty soils,thermal conductivity and specific volume heat of the saturated and unsaturated silty soils from Suzhou and Zhengzhou are measured with the ISOMET apparatus.The evolution relationships between thermo-physical parameters(thermal conductivity and specific volume heat),saturation and porosity are analyzed based on three phase composition of silty soils.The results indicate the thermal conductivity and specific volume heat of silty soils with constant porosity both are increased as saturation increased.The saturation of silty soils has a critical value(Sro).When the saturation Sr is greater than Sro,the specific volume heat is decreased as porosity increased.The relationship of porosity,saturation and thermal conductivity is nonlinear and the relationship of porosity,saturation and specific volume heat is linear.",
        "keywords": [
            "saturation",
            "thermal conductivity",
            "three-phase composition",
            "silty soil",
            "specific volume heat",
            "porosity"
        ],
        "authors": [
            {
                "name": "WANG Haibo",
                "org": "College of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "HE Zhongyi",
                "org": "Guangdong Tianxin Electric Power Engineering Testing Co.,Ltd.,Guangzhou ,China"
            }
        ],
        "venue": "Journal of Nanjing Forestry University(Natural Sciences Edition)",
        "year": 2012
    },
    "Yxvt2oZP": {
        "id": "Yxvt2oZP",
        "title": "The Aapplication and Development of Artificial Freezing Method in the Subway Construction",
        "abstract": "Artificial freezing method has good sealing water performance,stratum's good recoverability,obstacle avoidance of construction,and convenience.It can be applied to various ground conditions,especially in water-rich sand.With the increasing scale of subway construction in our country,the artificial freezing method has become the mainly auxiliary method.Taking the instance analysis as background,the paper discusses the artificial freezing method in the application of Metro's connected aisle,reinforcement for pass in and out of working pit in shield tunnel,accident repair,special projects,and replacement of shield tail brush crossing river/lake tunnel,gives artificial freezing applicable conditions,design parameters and the key technical parameters,and puts forward the problem and the development direction about further research on artificial freezing in the subway construction.",
        "keywords": [
            "reinforcement for pass in and out of working pit",
            "replacement of shield tail brush",
            "metro's connected aisle",
            "accident repair",
            "artificial freezing"
        ],
        "authors": [
            {
                "name": "Zhang Ting",
                "org": "College of Civil Engineering,Nanjing Forestry University,Nanjing "
            },
            {
                "name": "Yang Ping",
                "org": "College of Civil Engineering,Nanjing Forestry University,Nanjing "
            }
        ],
        "venue": "Forest Engineering",
        "year": 2012
    },
    "eb2HWHUe": {
        "id": "eb2HWHUe",
        "title": "Experimental Study on Frost Heave Properties of Cement-improved Soil",
        "abstract": "In order to reveal the law that the cement-improved soil controls frost heave,experimental research on frost heave properties were conducted with two typical soils in Nanjing region,clay and sand,mixed with the cement.The experiments show that:frost heave coefficient of clay or sand cement-improved soil declines exponentially with mixing ratio of cement increasing,enhances linearly with moisture content increasing,declines exponentially with instar increasing,enhances linearly with the cold junction temperature increasing,declines exponentially with load increasing besides there is an optimal mixing ratio,while it is the optimal mixing ratio,frost heave coefficient of cement-improved soil are lower,the optimal mixing ratio of clay and sand in Nanjing region is 10% and 5%.By comprehensive analysis,when using the freezing method,before freezing,a certain amount of cement can be mixed into the clay or sand,and it is necessary to place it for a period of time,which can reduce frost heave and thaw subsidence,thus reducing the harm to engineering and the environment.",
        "keywords": [
            "cement-improved soil",
            "artificial frozen soil",
            "frost heave",
            "mixing ratio of cement"
        ],
        "authors": [
            {
                "name": "BAO Jun-an",
                "org": "College of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "WANG Xu-nuo",
                "org": "College of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            }
        ],
        "venue": "Journal of Zhengzhou University(Engineering Science)",
        "year": 2013
    },
    "5t2PGg7j": {
        "id": "5t2PGg7j",
        "title": "Research Development of the Distribution of Plant Root Morphology and Discussion on Its New Methods",
        "abstract": "Root system,as an indispensable part in plants growing,plays a significant role in the reinforcement of shallow slope.And roots structure is an irregular complex shape with self-similarity that can hardly be quantitatively measured in Euclidean geometry.However,by applying fractal theory to the roots structure,it can lead to a good quantitative description of root morphology.Based on the reference discussing plant roots slope and the application of fractal theory in roots research both home and abroad,the paper proposed the idea of building the model of plant root morphology with L-system theory,and then numerically simulated the influence of the combined effect of the model and soil on the stability of slope by finite elements software.",
        "keywords": [
            "fractal theory",
            "eco-slope",
            "form distribution",
            "plant roots"
        ],
        "authors": [
            {
                "name": "Ji Xiaolei",
                "org": "College of Civil Engineering,Nanjing Forestry University,Nanjing "
            },
            {
                "name": "Yang Ping",
                "org": "College of Civil Engineering,Nanjing Forestry University,Nanjing "
            }
        ],
        "venue": "Forest Engineering",
        "year": 2011
    },
    "VmQ8NceW": {
        "id": "VmQ8NceW",
        "title": "A Finite-element Numerical Simulation Study of the Reinforced Soil Stability of Aquifer-free Shield Starting Zone",
        "abstract": "Shield starting is an accident-frequent phase in the construction of shield tunnel and ensuring the stability of reinforced soil in this phase is a key and urgent problem.In this paper,first,frequently-adopted methods for reinforcing the soil at the shield tunnel ends were summarized,then by combining the case of shield launching project(aquifer-free) of one station's west end in Suzhou Subway,a numerical simulation program was applied to conduct simulation analysis of reinforced areas at shield starting shafts under the most unfavorable construction condition\u2014with the sealed door removed.According to numerical simulations,when the longitudinal reinforcement length reaches 3 m,the soil shall move towards the working well in the tunneling direction of the shield tunnel,and the maximum displacement occurs in the center of exposed tunnel face,up to 12.92 m.Surface soil above the sealed door becomes deformed most,settling by approximately 3.0 m and soil within the strong reinforcement area is stressed within designed strength range,and the safety factor is 2.05,1.47 and 1.30 respectively.At the shield starting shaft which is aquifer-free,if the longitudinal reinforcement length reaches 3 m,requirements in both strength and deformation can be met.",
        "keywords": [
            "finite element analysis",
            "stability of reinforced soil",
            "Suzhou Subway",
            "shield launching",
            "aquifer-free"
        ],
        "authors": [
            {
                "name": "HU Jun",
                "org": "College of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "ZENG Hui",
                "org": "College of Civil Engineering,Nanjing Forestry University,Nanjing ,China;School of Civil Engineering and Architecture,Wuyi University,Jiangmen ,China"
            },
            {
                "name": "XIE Da-wei",
                "org": "Nanjing Section of Shanghai Railway Bureau,Nanjing ,China"
            }
        ],
        "venue": "Journal of Wuyi University(Natural Science Edition)",
        "year": 2012
    },
    "mG4bXznq": {
        "id": "mG4bXznq",
        "title": "Numerical Analysis of Artificial Thawing Temperature Field in High-confined Aquifer Reinforcement",
        "abstract": "Liquefied nitrogen freezing replacement shield brushes tail in China is the first application in shield tunnel excavation.With Qingchun Road cross-river tunnel of Hangzhou as an example,this paper applies ADINA finite element calculation software to compute thermal field for artificial thawing 3-D model,studies thermal spatial distribution and the variation laws of temperature with time,and makes the sensitivity analysis for influence factors of thawing temperature field.Through the contrast analysis of numerical simulation and field measurement,we get the development regularity of artificial thawing temperature field: artificial thawing time is longer with the increase of thermal conductivity and the increase of heat capacity;the higher the circulation hot water temperature is,the shorter the time of thawing is shorter;artificial thawing time is longer with the increase of latent;which solves the problem of shield brushes tail replacement in high-confined aquifer.",
        "keywords": [
            "temperature field",
            "frozen soil wall",
            "numerical analysis",
            "artificial thawing",
            "confined aquifer"
        ],
        "authors": [
            {
                "name": "CHEN Cheng",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "ZHANG Ting",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            }
        ],
        "venue": "Journal of Zhengzhou University(Engineering Science)",
        "year": 2012
    },
    "1lbPnitY": {
        "id": "1lbPnitY",
        "title": "A study of concrete early mechanical properties",
        "abstract": "The concrete mechanical properties of 1 d-7 d have very important effects on the durability of concrete structure.In order to explore the early mechanical property law of concrete,the mechanical properties of concrete in the first seven days are tested on the basis of four proportions.The research findings and conclusions are as follows:(1) the growth rate of cubic compressive strength,axial tensile strength,splitting tensile strength and ultimate tensile strain of concrete in the first three days is higher than the growth rate in 3 d\uff5e7d;(2) the axial tensile strength of concrete is greater than its splitting tensile strength in the first seven days;and(3) the pressure ratio of concrete based on splitting tensile strength and the pressure ratio of concrete based on axial tensile strength both tend to decrease firstly and then increase slowly,but the pressure ratio of concrete based on splitting tensile strength is greater than the pressure ratio of concrete based on axial tensile strength.",
        "keywords": [
            "durability",
            "mechanical properties",
            "concrete",
            "early-age"
        ],
        "authors": [
            {
                "name": "ZHAO Lian-zhen",
                "org": "Institute of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Institute of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "LIU Cheng",
                "org": "Institute of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            }
        ],
        "venue": "Hydro-Science and Engineering",
        "year": 2013
    },
    "Fz6kPbXw": {
        "id": "Fz6kPbXw",
        "title": "Study on Prediction Model of Frozen Soil Strength Based on Back-propagation Neural Network",
        "abstract": "Artificial freezing method has been used in Suzhou subway interconnecting channel construction as an auxiliary technique.However,there is no normalized parameter about frozen soil strength in Suzhou area for design at present.Therefore,a prediction model is established in this paper considering the influence of temperature,water content and dry density on typical frozen soil strength in Suzhou subway using artificial neural network to map the non-linearity among these influencing factors.The result shows that BP network has higher solving capability and is more accurate than other linear regression methods,from which the predicted value is closer to measured value.In addition,it is simple and practical.It would provide a new way to obtain the parameter which cannot be achieved in test.",
        "keywords": [
            "water content",
            "compressive strength",
            "dry density",
            "temperature",
            "back-propagation neural network"
        ],
        "authors": [
            {
                "name": "HE Jun",
                "org": "College of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "DONG Chao-wen",
                "org": "Suzhou Subway Co.,Ltd.,Suzhou ,Jiangsu,China"
            }
        ],
        "venue": "Subgrade Engineering",
        "year": 2011
    },
    "z0C8nurF": {
        "id": "z0C8nurF",
        "title": "Analysis on the spatial non-stationarity of urban housing pricing factors",
        "abstract": "Applying housing feature pricing theory, the housing estate's average price in Nanjing was selected as a dependent variable in Sep. 2011, and 8 factors affecting housing prices as an independent variable is quantized. Then geographically weighted regression was processed. Compared with the traditional OLS estimation, GWR model has a better fit. At the same time, it has been found that all significant factors influencing housing prices in the spatial distribution are different and the characteristics of this difference are revealed.",
        "keywords": [
            "Geographically weighted regression",
            "Hedonic price method",
            "Housing price affect factors",
            "Spatial non-stationarity"
        ],
        "authors": [
            {
                "name": "Hui Zeng",
                "org": "Nanjing Forestry University(Nanjing Forestry University,Nanjing Forestry Univ.),Nanjing,China"
            },
            {
                "name": "Ping Yang",
                "org": "Nanjing Forestry University(Nanjing Forestry University,Nanjing Forestry Univ.),Nanjing,China"
            },
            {
                "name": "ZHU Jian-jun",
                "org": "Nanjing Forestry University(Nanjing Forestry University,Nanjing Forestry Univ.),Nanjing,China"
            }
        ],
        "venue": "Hunan Daxue Xuebao/Journal of Hunan University Natural Sciences",
        "year": 2012
    },
    "a00Na6LI": {
        "id": "a00Na6LI",
        "title": "Development and application of large-scale multi-functional frozen soil-structure interface cycle-shearing system",
        "abstract": "In the permafrost regions and artificial frozen soil projects, there are many problems of interface between frozen soils and architectural construction, but there is no related test equipment, which can be used for researches on frozen soil-structure interface. Based on this, a new apparatus called large-scale multi-functional cycle direct shear apparatus for frozen soil-structure interface (DDJ-1) is developed. The shear system is excellent in many performances: (1) the system can precisely realize the temperature control in the range of 0~-20\u00b0C; (2) four normal boundary conditions, including constant stress, constant displacement, constant stiffness and zero stress, can be exerted accurately in the system; (3) various roughnesses of interface can be simulated; (4) two shear forms, circular shear and drab shear, can be provided; (5) the state of failure, thickness and shear displacement of the shear bands in frozen soils can be monitored; and (6) the stress applying, displacement control and temperature regulation can be precisely measured. The test results show that the apparatus can accurately reproduce the mechanical and deformational behaviors of the interface between frozen soils and structures, meanwhile, it can provide a experimental basis and important ideas for carrying out researches on the frozen soil-structure interface.",
        "keywords": [
            "Cyclic shear",
            "Direct shear apparatus",
            "Frozen soil",
            "Interface",
            "Temperature control"
        ],
        "authors": [
            {
                "name": "ZHAO Lian-zhen",
                "org": "Nanjing Forestry University(Nanjing Forestry University,Nanjing Forestry Univ.),Nanjing,China"
            },
            {
                "name": "Ping Yang",
                "org": "Nanjing Forestry University(Nanjing Forestry University,Nanjing Forestry Univ.),Nanjing,China"
            },
            {
                "name": "WANG Hai-bo",
                "org": "Nanjing Forestry University(Nanjing Forestry University,Nanjing Forestry Univ.),Nanjing,China"
            }
        ],
        "venue": "Yantu Gongcheng Xuebao/Chinese Journal of Geotechnical Engineering",
        "year": 2013
    },
    "lZVqWyRg": {
        "id": "lZVqWyRg",
        "title": "Numerical simulation study on properties of different cement-soil material in small stiffness cement-soil retaining wall",
        "abstract": "The small rigidity stiff cement-soil retaining wall in soft soil area can serve as a kind of high technology,economy and social benefit pit supporting structure.This paper created 3D finite element model,analyzed the displacement and stress fields of soil and bracing structures with the different excavation depth(condition) and different cement-soil materials,and showed the interaction of the steel and cement-soil by studying the engineering instances.Futhermore,this paper presented the reasonable proposals for the practical engineering construction scheme selection based on analysis results.",
        "keywords": [
            "Numerical simulation",
            "Cement ratio",
            "Bracing structure",
            "Small rigidity stiff cement-soil retaining wall"
        ],
        "authors": [
            {
                "name": "YIN Peng",
                "org": "School of Civil Engineering & Mechanic,Central South University of Forestry and Technology,Changsha Hunan ,China;School of Civil Engineering,Central South University,Changsha Hunan ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing Jiangsu ,China"
            },
            {
                "name": "JI Xiaolei",
                "org": "School of Civil Engineering,Jiangsu Radio And TV University,Nanjing Jiangsu ,China"
            }
        ],
        "venue": "Railway Engineering",
        "year": 2013
    },
    "1M9FBUqD": {
        "id": "1M9FBUqD",
        "title": "Sensitivity study of soil thermal field in horizontal freezing shield portal reinforced by cement",
        "abstract": "Relying on the horizontal soil freezing construction for 2\ufe5ftunnel portal of shield entry projects in railway station of the second line of Suzhou Metro,numerical model of freezing temperature field is built for horizontal freezing shield portal by software.Effects of convection coefficient,thermal conductivity,volumetric heat capacity,latent heat of phase change,cement parameter on development of freezing effect were studied.The study demonstrates that the convection coefficient and volumetric heat capacity each with the freezing effect show two linear decreasing functions.The thermal conductivity with the freezing effect shows a linear decreasing function.But the latent heat of phase change has no effect on freezing effect.When the cement parameter is 20% in silty clay and 16% in silty soil,the freezing effect is the best.",
        "keywords": [
            "temperature field",
            "portal",
            "sensitivity study",
            "horizontal freezing",
            "numerical simulation"
        ],
        "authors": [
            {
                "name": "WANG Jie",
                "org": "College of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "ZHANG Xiangyu",
                "org": "College of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "WANG Xunuo",
                "org": "College of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            }
        ],
        "venue": "Journal of Nanjing Forestry University(Natural Sciences Edition)",
        "year": 2013
    },
    "vbODp2hq": {
        "id": "vbODp2hq",
        "title": "Effect of different factors on the short pipe end's thickness of frozen wall and horizontal freezing temperature field",
        "abstract": "The thesis takes Nanjing metro line 2 Yixian Bridge Station shield tunneling horizontal cup-shaped freezing wall as engineering background, establishing the finite element model of temperature field. The closure time and short pipe end's thickness of frozen wall is analyzed. The results indicate that: on the basis of the same freezing conditions, the lower of the strata's initial temperature, circulating brine water, latent heat and heating capacity with the larger freezing pipe diameter and coefficient of thermal conductivity, the short pipe closure time is shorter, the strata's temperature is lower and the short pipe end's thickness is larger. In the range of various factors, the short pipe closure time is 7~17 d, the short pipe end's thickness can be up to 30~77 cm in 40 d of freezing. The protection layer thickness ensures that the cup-shaped freezing wall is stable after removing the freezing tubes of central zone.",
        "keywords": [
            "Freezing temperature field",
            "Horizontal cup-shaped froze",
            "Short pipe end's thickness of frozen wall"
        ],
        "authors": [
            {
                "name": "Ting Zhang",
                "org": "Nanjing Forestry University(Nanjing Forestry University,Nanjing Forestry Univ.),Nanjing,China"
            },
            {
                "name": "Ping Yang",
                "org": "Nanjing Forestry University(Nanjing Forestry University,Nanjing Forestry Univ.),Nanjing,China"
            }
        ],
        "venue": "Wuhan Ligong Daxue Xuebao/Journal of Wuhan University of Technology",
        "year": 2012
    },
    "WJatVhnX": {
        "id": "WJatVhnX",
        "title": "Research on Factors Influencing Frost Heaving and Thaw Collapsing Based on Grey Relational Preponderance Analysis",
        "abstract": "In order to study the extent of water content,dry density,cold end temperature and load influencing frost heaving and thaw collapsing,the model of grey relational preponderance analysis is established to calculate the test data of frost heaving and thaw collapsing of mucky clay at shallow strata in Nanjing region and to analyze various factors influencing the coefficients of frost heaving and thaw collapsing.The result shows that the factors influencing the two coefficients in turn are water content,cold end temperature,dry density,and load;and demonstrates that the use of grey relational preponderance analysis is accurate and feasible.It is a good method for analysis.",
        "keywords": [
            "thaw collapsing coefficient",
            "frost heaving coefficient",
            "influencing factor",
            "relational preponderance analysis"
        ],
        "authors": [
            {
                "name": "BAO Jun-an",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "CHEN Cheng",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            }
        ],
        "venue": "Subgrade Engineering",
        "year": 2012
    },
    "gyAdP9q4": {
        "id": "gyAdP9q4",
        "title": "An Analysis of Causes and Countermeasures of Segment Floating of Super Large Diameter Shield Tunnels",
        "abstract": "Because of its anti-floating problem,super large diameter shield tunnel segment finds itself difficult to gain popularization.The analysis suggests that performances and mechanism of segment floating are closely related to geological condition,characteristics and construction parameters of shield construction,shield attitude,covering depth,joints of segment,construction disturbance,grouting technology,grout characteristics,and the like.Moreover,some concrete countermeasures are proposed to control the uplift of the super lager diameter shield tunnel segments,with a view to yielding some insights into construction of shallow covering shield in underwater tunnels and metro tunnels with super large diameters.",
        "keywords": [
            "segment floating",
            "mechanism",
            "super large diameter shield tunnel",
            "anti-floating countermeasure"
        ],
        "authors": [
            {
                "name": "SHEN Xin-guo",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "WANG Xu-nuo",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            }
        ],
        "venue": "Journal of Nanjing Institute of Technology(Natural Science Edition)",
        "year": 2011
    },
    "JNmGRItb": {
        "id": "JNmGRItb",
        "title": "Temperature measurements of long-distance liquid nitrogen freezing in high-confined aquifer reinforcement",
        "abstract": "Based on the Qingchun Road cross-river tunnel of Hangzhou,frozen parameters and process of long-distance liquid nitrogen freezing in high-confined aquifer are obtained,and field measurements of freezing temperature are performed.The results show that the long-distance liquid nitrogen freezing temperature should be guaranteed in the way when the temperature reaches the working liquid nitrogen below-100\u2103,and the exit temperature after cycling should be held between-50\u2103\uff5e-70\u2103.By using three 1 cm-thick layers of polyethylene insulating materials and three layers of sealed film alternately,the heat preservation effect is obvious,the package temperature has a rise of 0.070 \u2103 / m,and the longest distance for the liquid nitrogen freezing can reach 1000 m.The development speed of permafrost from large to small order is gravel layer> silt sand layer> silt clay layer.The temperature of segment is affected by external environment,and the temperatures at segment-shield shell interface before,during and after welding of shield tail brushes are 5.4\u2103\uff5e-3.2\u2103,19.3\u2103\uff5e8.7\u2103 and 12.7\u2103\uff5e4.8\u2103 so as to ensure the thawing and welding quality of frozen walls.Compulsory thawing only needs 2 days to achieve the condition for the shield,and this procedure has a total duration of 23 days,which solves the problem of replacing shield tail brushes in confined aquifer.",
        "keywords": [
            "temperature field",
            "frozen soil wall",
            "long-distance liquefied nitrogen freezing",
            "shield tail brush",
            "thawing",
            "confined aquifer"
        ],
        "authors": [
            {
                "name": "CHEN Cheng",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "ZHANG Ting",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "SHI Zhi-ming",
                "org": "Shanghai Branch,The Fifth China Coal Construction Company,Shanghai ,China"
            }
        ],
        "venue": "Chinese Journal of Geotechnical Engineering",
        "year": 2012
    },
    "PyI2uirn": {
        "id": "PyI2uirn",
        "title": "NUMERICAL ANALYSIS AND REINFORCING PROTECTION OF TYPICAL STONE ARCH BRIDGE STRUCTURE",
        "abstract": "Taking Taishan Bridge,an ancient stone arch bridge,as an example,through field survey and numerical analysis on spatial bearing performance of stone arch bridge,it is found that the maximum vertical displacement of arch ring happens at the middle part of midspan and that first destructive cracks are generated on auxiliary components at upper part of arch ring and arch angle.It is suggested that during maintenance and protection of ancient stone arch bridge,auxiliary components at upper part of arch ring and arch angle base is reinforced at first;low-compressibility lightweight filling with good water stability may be used to replace the original back arch filling,meanwhile,monitoring is carried out on deformation of stone arch bridge.",
        "keywords": [
            "protection",
            "finite element",
            "spatial force bearing",
            "ancient stone arch bridge",
            "reinforcement"
        ],
        "authors": [
            {
                "name": "SHI Quan-bin",
                "org": "Taizhou Polytechnical College,,Taizhou,Jiangsu,China"
            },
            {
                "name": "YANG Ping",
                "org": "Nanjing Forestry University,,Nanjing,China"
            },
            {
                "name": "ZHU Hua-ping",
                "org": "Nanjing Forestry University,,Nanjing,China"
            },
            {
                "name": "JIANG Feng-chang",
                "org": "Taizhou Polytechnical College,,Taizhou,Jiangsu,China;School of Civil Engineering,Tongji University,,Shanghai,China"
            }
        ],
        "venue": "Architecture Technology",
        "year": 2012
    },
    "7ALOoiP5": {
        "id": "7ALOoiP5",
        "title": "Numerical simulation of the effects of horizontal deformation of the supporting structure on surface settlement in deep foundation pits",
        "abstract": "A numerical simulation was carried out using the finite difference software FLAC3D regarding horizontal deformation of a supporting structure and the resultant surface settlement. A comparison was made using the measured values. The results indicate that: the maximum horizontal displacement of the diaphragm wall occurs at the top of the wall; the horizontal displacement curve presents a \"semi-cup\" composite form with several inflection points; and the curve of the surface settlement at the rear of the diaphragm wall demonstrates a \"concave\" form, which complies with the results obtained by monitoring. The Ad/Aq ratio is different because of different construction scenarios and it will decrease with an increasing depth of excavation, which shows that the surface settlement lags. Based on the quantitative analysis of various construction cases, it was determined that the ratio of Ad/Aq is around 0.4 to 0.6. The affected scope of surface settlement induced by pit excavation is mainly distributed at 1.5 times the excavation depth; the d/H value is between 0~1.0 for the main affected zone and 1.0-1.5 for the secondary affected zone. The maximum settlement occurred at the area with a d/H value of 0.5.",
        "keywords": [
            "Deep foundation pit",
            "Horizontal deformation",
            "Numerical simulation",
            "Supporting structure",
            "Surface Settlement"
        ],
        "authors": [
            {
                "name": "Jieming Zheng",
                "org": "Yulin Urban and Rural Planning Design Institute(Yulin Urban and Rural Planning Design Institute),,China"
            },
            {
                "name": "Jiuqi Xie",
                "org": "Yulin Urban and Rural Planning Design Institute(Yulin Urban and Rural Planning Design Institute),,China"
            },
            {
                "name": "Ping Yang",
                "org": "Nanjing Forestry University(Nanjing Forestry University,Nanjing Forestry Univ.),Nanjing,China"
            },
            {
                "name": "Zhong Zhang",
                "org": "Yulin Urban and Rural Planning Design Institute(Yulin Urban and Rural Planning Design Institute),,China"
            }
        ],
        "venue": "Modern Tunnelling Technology",
        "year": 2013
    },
    "p8rv81ax": {
        "id": "p8rv81ax",
        "title": "Test research on unconfined compressive strength of freezing cement soil",
        "abstract": "To provide the freezing design parameters for the project that needs the cement reinforced soil,the artificial ground freezing method for the added reinforcement in urban subway constructions is used.In order to master the mechanical properties and design parameters of frozen cement soil,a series of tests research on the unconfined compressive test of freezing cement soil in laboratory are conducted.The tests showe that with the decreasing temperature or the increasing cement content,the unconfined compressive strength of the cement soil linearity increases.With the increasing curing period,the unconfined compressive strength of the cement soil logarithmically increases.With the decreasing temperature,the elastic modulus of cement soil linearly increases.In normal temperature,the elastic modulus increases linearly with the increase in cement ratio.In temperature of-10\u2103,the elastic modulus exponential increases with the increase in cement ratio,and the elastic modulus logarithmically increases with the cement ratio increases.Of the three factors of temperature,cement ratio and age,the impact of temperature on the compressive strength of cement soil is the largest.With the increasing cement content and curing period,the ratio of the compressive strength ato the compressive strength of freezing cement soil and cement soil at room temperature exponentially decreases,and eventually stabilizes.",
        "keywords": [
            "elastic modulus",
            "freezing cement soil",
            "curing period",
            "cement mixing ratio",
            "temperature"
        ],
        "authors": [
            {
                "name": "WANG Xu-nuo",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing,Jiangsu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing,Jiangsu ,China"
            },
            {
                "name": "BAO Jun-an",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing,Jiangsu ,China"
            },
            {
                "name": "ZHANG Xiang-yu",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing,Jiangsu ,China"
            }
        ],
        "venue": "Hydrogeology & Engineering Geology",
        "year": 2013
    },
    "XlC1K5sK": {
        "id": "XlC1K5sK",
        "title": "The Finite Element Analysis on Small Rigidity Portal Frame Steel Stiffness Cement-soil Retaining Structure of Adina",
        "abstract": "Small rigidity portal frame steel stiffness cement-soil structure has the function of retaining small rigidity material and cement-soil work together to form a dual function of retaining and sealing the foundation pit structures.According to finite element software ADINA,simulation analysis shows that,cement material properties,steel type,the thickness of the cement retaining wall and steel frame width are affected in varying degrees of resistance of deformation of small rigidity portal frame steel stiffness cement-soil retaining structure,and as the Small rigidity portal frame steel stiffness cement-soil retaining structure provide the basis for design theory and construction.",
        "keywords": [
            "cement-soil",
            "the finite element",
            "small rigidity portal frame",
            "ADINA",
            "foundation pit supporting"
        ],
        "authors": [
            {
                "name": "HE Pei-ling",
                "org": "Nanjing Forestry University,Nanjing "
            },
            {
                "name": "LUO Xiang-hua",
                "org": "Nanjing Forestry University,Nanjing "
            },
            {
                "name": "YANG Ping",
                "org": "Nanjing Forestry University,Nanjing "
            }
        ],
        "venue": "Journal of Yangtze University(Natural Science Edition)",
        "year": 2011
    },
    "7CwV8Szq": {
        "id": "7CwV8Szq",
        "title": "Effect of Different Factors on the Heat Conduction Coefficient of Shallow Top Soil",
        "abstract": "The heat conduction coefficient of soil is an important parameter for predicting the development of artificial freezing temperature field and thickness of frozen wall.The parameter mainly depends on the factors including the component of solid grain,moisture content and density of the soil.This article studies the influence of some factors including moisture content,dry density and temperature on the heat conduction coefficient of soil such as mucky clay,mucky silty clay and silty sand under normal temperature and ten degrees below zero.The results show that different kinds of soil,moisture content and dry density affect the conduction coefficient obviously,and in the range of moisture content and dry density tested,the coefficient increases linearly with increase of moisture content and dry density.What's more,the coefficient of frozen soil is greater than that of soil at normal temperature.In addition,with moisture content increasing the coefficient growth of frozen soil is relevant to the dry density.",
        "keywords": [
            "moisture content",
            "frozen soil",
            "heat conduction coefficient",
            "dry density",
            "temperature"
        ],
        "authors": [
            {
                "name": "Zhang Ting",
                "org": "College of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "Yang Ping",
                "org": "College of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            }
        ],
        "venue": "Chinese Journal of Underground Space and Engineering",
        "year": 2012
    },
    "EKLybLt6": {
        "id": "EKLybLt6",
        "title": "The Experimental Study on the Effect of Vegetation Root on the Soil Shear Strength",
        "abstract": "Taking bermudagrass as the research object,the author analysis the liquid plastic limit,maximum dry density,optimum moisture content of the experimental soil,adopt the single-factor method,what the GDS triaxial tests have been carried out in three ways: the vertical,horizontal,and horizontal direction at 30\u00b0.The author also draw the stress-strain curves,the envelope diagram of samples,and analysis the relationship of bermudagrass reinforced earth principal stress difference and the axial strain.The results show that prime soil and soil containing the root of their confining pressure-linear relationship between deviator stress;implantation of the root less impacted on the effective internal friction angle \u03c6;The root has little impact on the cohesion of soil when they are placed horizontally or aslant,however,the vertical placement is much more effective.It is due to the horizontal and the inclined position reduces the effective shear area of samples.",
        "keywords": [
            "Add root angle",
            "Mechanism",
            "Root silk strength",
            "Rotundus reinforced soil",
            "Shear strength",
            "Vegetation slope protection"
        ],
        "authors": [
            {
                "name": "ZHANG Xiang-yu",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "WANG Lei",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "JI Xiao-lei",
                "org": "School of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            }
        ],
        "venue": "Journal of Wuhan University of Technology",
        "year": 2012
    },
    "BTAQFJf4": {
        "id": "BTAQFJf4",
        "title": "Effects of unilateralist freezing on the moisture migration of soil",
        "abstract": "The test object was column sample of shallow top soil in Nanjing,Suzhou and Wuxi,the unsaturated soil was tested by unilateralist freezing way tests on unsaturated soil,the soil's moisture migration behaviors were analyzed under the influence of moisture content,dry density and freezing time.The following conclusions could be drawn:the sample's freezing front position was relationship with freezing time,the freeze frontal movement speed of begin two hours(1.55 cm/h) was slightly higher than the end of the two hours(1.20 cm/h).The moisture migration capacity and scope were negative correlation with the soil's dry density,the top and bottom moisture variation of sample was relationship with dry density.After unilateralist freezing,the moisture migration was remarkable in unsaturated muddy clay when soil's moisture content was higher.The results also showed that mealy sand was apt to quickly freeze,and moisture migration capacity of that was little impacted by initial moisture content of soil.The water content increment was the same in each frozen section of silty clay under the same freezing conditions.",
        "keywords": [
            "moisture content",
            "unilateralist freezing",
            "soil's moisture migration",
            "dry density",
            "soil"
        ],
        "authors": [
            {
                "name": "ZHANG Ting",
                "org": "College of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Civil Engineering,Nanjing Forestry University,Nanjing ,China"
            }
        ],
        "venue": "Journal of Nanjing Forestry University(Natural Sciences Edition)",
        "year": 2013
    },
    "oSkGhcAQ": {
        "id": "oSkGhcAQ",
        "title": "Characteristics of Clustering Extreme Drought Events in China During 1961-2010",
        "abstract": "Based on the Multi-Scale Standardized Precipitation Index (MSPI), extreme severe drought events in China during 1961\u20132010 were identified, and the seasonal, annual, and interdecadal variations of the clustering extreme drought events were investigated by using the spatial point process theory. It is found that severe droughts present a trend of gradual increase as a result of the significant increase and clustering tendency of severe droughts in autumn. The periodicity analysis of the clustering extreme droughts in different seasons suggests that there is a remarkable interdecadal change in the occurrence of clustering extreme droughts in winter. Meanwhile, it is revealed that the clustering extreme drought events exhibit greatly different annual mean spatial distributions during 1961\u20132010, with scattered and concentrated clustering zones alternating on the decadal timescale. Furthermore, it is found that the decadal-mean spatial distributions of extreme drought events in summer are correlated out of phase with those of the rainy bands over China in the past 50 years, and a good decadal persistence exists between the autumn and winter extreme droughts, implying a salient feature of consecutive autumn-winter droughts in this 50-yr period. Compared with other regions of China, Southwest China bears the most prominent characteristic of clustering extreme droughts.",
        "keywords": [
            "clustering",
            "extreme drought events",
            "interdecadal",
            "seasonal"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": " China Meteorological Administration Training Center, Beijing "
            },
            {
                "name": "XIAO Ziniu",
                "org": " China Meteorological Administration Training Center, Beijing "
            },
            {
                "name": "YANG Jie",
                "org": " National Climate Center, China Meteorological Administration, Beijing  3 College of Atmospheric Science, Lanzhou University, Lanzhou "
            },
            {
                "name": "LIU Hua",
                "org": " China Meteorological Administration Training Center, Beijing "
            }
        ],
        "venue": "\u6c14\u8c61\u5b66\u62a5(\u82f1\u6587\u7248)",
        "year": 2013
    },
    "QYF76nBd": {
        "id": "QYF76nBd",
        "title": "Comparison of Diurnal Temperature Variation in Urban and Rural Areas in Beijing and Its Seasonal Change",
        "abstract": "On the basis of quality control of hourly temperature datasets from 67 Automatic Weather Stations (AWSs) in the last four years (2007\u20132010), the characteristics of diurnal temperature variations over urban and rural areas in Beijing are analyzed. The statistical distributions of the time of maximum high temperature and minimum low temperature in the daily cycle, which are the two most important characteristic values describing the diurnal variation, are analyzed. The difference in diurnal temperature variation between urban and rural areas in Beijing and its seasonal change are investigated using the results. Further, the characteristic diurnal variations in the temperature change in different units of time is studied, as well as their statistically determined emergence times. The different influences in urban and rural areas are also discussed. The results revealed the following. The maximum high temperature generally appears earlier in rural areas than in urban areas, but the minimum low temperature occurs later in rural areas than in urban areas. Compared with that in rural area, the characteristics of diurnal temperature variation are more concentrated for the AWSs in urban areas. The emergence times of the maximum high temperature and minimum low temperature also exhibit greater agreement for AWSs in urban areas. The characteristic diurnal variations change obviously with the season. For the maximum high temperature, the emergence time is centralized in autumn and winter but dispersive in spring and summer. The trend is the opposite for the minimum low temperature, which is centralized in spring and summer but dispersive in autumn and winter. The positive and negative temperature changes are asymmetrical on a daily cycle. The temperature shows a sharp rise but a slow decrease during a day. Urban areas typically have a smaller temperature range than rural areas in spring and autumn but not in summer and winter. Analyses of the temperature change rate in different time intervals showed that the sharpest change takes place in three hours. The statistical pattern of the time at which the maximum positive temperature change appears is different from that for the negative change. The time at which the maximum positive (negative) temperature appears is the most concentrated in winter (autumn) but the most dispersive in summer (spring). The differences between urban and rural areas in the characteristic diurnal variations in the maximum high and minimum low temperatures and the characteristics of temperature change are caused mainly by the larger thermal capacity of urban areas. Investigation of the characteristics of diurnal temperature characteristic and its differences in different seasons and different regions is important for better understanding of regional climate and the influence of urbanization. It can also provide climate background for refined weather forecasting.",
        "keywords": [
            "Maximum temperature",
            "Diurnal variation characteristics",
            "Difference between urban and rural areas",
            "Temperature change",
            "Minimum temperature"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": " China Meteorological Administration Training Center, Beijing "
            },
            {
                "name": "XIAO Ziniu",
                "org": " China Meteorological Administration Training Center, Beijing "
            },
            {
                "name": "LIU Weidong",
                "org": " Institute of Urban Meteorology, China Meteorological Administration, Beijing "
            }
        ],
        "venue": "Chinese Journal of Atmospheric Sciences",
        "year": 2013
    },
    "kP27PKra": {
        "id": "kP27PKra",
        "title": "Trends and Difference Analyses of Temperature Extremes in Rural and Urban Areas in Beijing",
        "abstract": "The frequency and intensity of temperature extremes in Beijing was studied by using the standardized weather station data from 1979 to 2008. The differences between rural and urban areas and their relationship to the urban heat island intensity are discussed. The analysis results show that the decrease in the minimum temperature events over the urban area [-5.94 d (10 a)-1 ] was slightly higher than that over rural areas [-5.28 d (10 a)-1 ] over the 30-a period, while the difference of maximum temperature changes between the urban [4.33 d (10 a)-1 ] and rural [4.42 d (10 a)-1 ] areas were much smaller. The authors also found that the frequencies of extreme events between the urban and rural areas were very small. The investigation of the intensity revealed similar trends. Although the temperature extremes over the urban area were clearly stronger than over the rural areas, in the urban area the decreasing trend of minimum temperature extremes was slightly greater [0.042 \u00b0C (10 a)-1 ] than the increasing trend of the maximum temperature extremes, while in the rural area the deceasing trend of the minimum temperatures was slightly less [0.052 \u00b0C (10 a)-1 ] than the increasing trend of the maximum temperatures. The study on the differences between the urban and rural areas suggested that the intensity of the temperature extremes was stronger over the urban area than that over the rural area. The difference in temperature extremes ship between the urban and rural areas was generally a positive value (except for the negative difference in maximum high temperature in 1982 and 1885). On the other hand, statistical analysis showed no correlationship between the intensity of the urban heat island and the rural\u2013urban difference of extreme temperature events, indicating that the impact of the urban heat island on the urban and rural areas is mainly coincident for a super-city like Beijing.",
        "keywords": [
            "Extreme temperature event",
            "Urban heat island",
            "Urban-rural difference",
            "Trend"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": " China Meteorological Administration Training Center, Beijing "
            },
            {
                "name": "LIU Weidong",
                "org": " Institute of Urban Meteorology of Beijing, China Meteorological Administration, Beijing "
            },
            {
                "name": "HOU Wei",
                "org": " National Climate Center, China Meteorology Administration, Beijing "
            }
        ],
        "venue": "Climatic and Environmental Research",
        "year": 2013
    },
    "x7ZsocJP": {
        "id": "x7ZsocJP",
        "title": "Evaluating the Quality of Temperature Measured at Automatic Weather Stations in Beijing",
        "abstract": "Data quality is a basic assurance for meteorological researches and data applications.Considering data integrality,veracity and confidence,the standard for AWS(automatic weather station) data quality assessment is defined band a set of index is established for AWS data quality assessment and a feasible observation data quality control flow is designed.Following the definition and principia,AWS data can be categorized as correct,mistake and dubious data.The spatial and temporal consistent detections are employed in the data quality control flow.Based on the quality control flow and assessment index,hourly data measured by 187 AWS in Beijing from 1998 to 2009 is evaluated.The results show that the AWS net of Beijing is set up following a fine layout.Although the distribution of AWS is uneven,most AWS is located in urban area such as Haidian and Chaoyang districts,especially in early time of the AWS construction process, some AWS are set up in mountainous area according to the need of different region representative.It is beneficial for urban and rural climate comparing,data sequence reconstruction and regional climate research. The severe missing data is rare,and discrete and slight continuous missing data is just found in concentrated regions and with regional consistent characteristic.The highest error rate of AWS temperature data is 3.8%and it is below 1%in most years.The amount of dubious data is much more than the mistaking data.But more than half of dubious data can be got back after space consistency check.It means that the AWS data in Beijing is reliable.The rates of mistaken data are above 20%after 2004.It shows that the amount of dubious data is not related with the rate of mistake data and on the other hand the uncertainty of AWS data set is reduced after 2004.In conclusion,the assessment result reveals that the AWS data in Beijing are accurate,reliable and show great potential in the future application.",
        "keywords": [
            "quality evaluation",
            "automatic weather stations",
            "Beijing",
            "data-lacking",
            "temperature"
        ],
        "authors": [
            {
                "name": "Yang Ping",
                "org": "China Meteorological Administration Training Center,Beijing "
            },
            {
                "name": "Liu Weidong",
                "org": "Institute of Urban Meteorology of Beijing,China Meteorological Administration.Beijing "
            },
            {
                "name": "Zhong Jiqin",
                "org": "Institute of Urban Meteorology of Beijing,China Meteorological Administration.Beijing "
            },
            {
                "name": "Yang Jie",
                "org": "College of Atmospheric Sciences,Lanzhou University,Lanzhou "
            }
        ],
        "venue": "Journal of Applied Meteorological Science",
        "year": 2011
    },
    "dz78KBqc": {
        "id": "dz78KBqc",
        "title": "Evaluating the Quality of Meteorological Data Measured at Automatic Weather Stations in Beijing during 1998-2010",
        "abstract": "Data quality control is a basic assurance for meteorological researches and data applications. In order to efficiently use the data sets from AWS(Automatic Weather Station) constructed in 1998, hourly data(including precipitation, relative humidity, air pressure, wind speed and direction) measured by 187 AWS over Beijing from 1998 to 2010 were evaluated by its integrality, veracity and confidence in the paper. The approach included the definition and principle applied in the temperature data assessment, in which the AWS data can be divided into correct, severe missing, missing, discrete and slight continuous missing, and dubious data. The spatial and temporal consistent detections are employed in the data quality control flow. The results show as follows: The AWS net of Beijing was set up following a fine layout. During the AWS construction process, the regional character was considered for the representation of AWS. Even in the beginning period, the AWS were set up in urban areas and mountainous areas as well according to the need of different region representation. It is beneficial to urban and rural climate comparison, data sequence reconstruction and regional climate research. The collectivity of the five kinds AWS data is fine. The severe and bad missing data was few. The dispersing and lightly consecutive missing data were concentrated with regional consistency. It is shown from the error test that the incidence of mistakes were different among the five kinds data. Although the number of extreme errors in precipitation is higher than other error styles, the highest number of cumulative errors of precipitation data is not beyond 43(2005). Relative humidity and air pressure, had errors almost simultaneously. The results of suspicious data discriminating revealed that the suspicious data of relative humidity had the highest proportion in 2003 and 1999, after 2004, while the suspicious data of pressure, which failed, in space consistency check occupy a larger proportion in 2004. The cause remains for further study.",
        "keywords": [
            "automatic weather stations",
            "quality evaluation",
            "data-lacking"
        ],
        "authors": [
            {
                "name": "Yang Ping",
                "org": ""
            },
            {
                "name": "Liu Weidong",
                "org": ""
            }
        ],
        "venue": "Advances in Meteorological Science and Technology",
        "year": 2013
    },
    "gdBvzawz": {
        "id": "gdBvzawz",
        "title": "A Composite Index of Daily Extreme Precipitation in China Based on Stochastic Resort Detrended Fluctuation Analysis",
        "abstract": "By combining detrended fluctuation analysis(DFA) method with surrogate data method,and using the heuristic segmentation algorithm as well as Chi-Square statistics,the stochastically re-sorting detrended fluctuation analysis(S-DFA) method was developed to define the threshold of extreme events.By using S-DFA method,we obtained the thresholds of extreme precipitation events from 1961 to 2006 in China and analyzed its spatial-temporal distribution characteristics.We also validated the effectiveness of S-DFA method through extreme events detection by using precipitation series.The composite index of extreme precipitation events was given in this paper,which integrated the information about frequency and strength of extreme precipitation events,considering the characteristic of regional climate system.Based on the composite index,we divided into three zones according to different precipitation rank of extreme precipitation events from 1961 to 2006 in China.The composite index of extreme precipitation maintained smooth fluctuation with no obvious increasing or decreasing trend on the whole during 1961-2006 in Chine.",
        "keywords": [
            "extreme precipitation event",
            "composite index",
            "stochastic resort detrended fluctuation analysis",
            "threshold"
        ],
        "authors": [
            {
                "name": "HOU Wei",
                "org": "National Climate Center,Beijing ,China"
            },
            {
                "name": "QIAN Zhonghua",
                "org": "College of Atmospheric Sciences,Lanzhou University, Lanzhou ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Training Center of China Meterological Administration,Beijing ,China"
            },
            {
                "name": "FENG Guolin",
                "org": "National Climate Center,Beijing ,China"
            }
        ],
        "venue": "Journal of Arid Meteorology",
        "year": 2012
    },
    "Htr7SmNw": {
        "id": "Htr7SmNw",
        "title": "Rectification on applicability of mixed point process decomposition",
        "abstract": "A mixed point process decomposition based on k-th nearest distance is introduced. Disadvantage in former researches is revealed and resovled. It is shown that the threshold of applicability judgment is not influenced as R is larger or smaller than critical value. Primary influences show as R is close to the theoretical calculation. Difference between theoretical and calculated R is analyzed. And numerical experiment is done. It is noticed that whether the critical value is revised or not, it depends on the number of point with almost a negative correlativity. In other words, the critical value is higher as sample size is small but is lower as sample size is large. As R lies in critical conditions, the initialized valid value of k increases with increasing of sample size.",
        "keywords": [
            "Clusters",
            "k-th nearest-neighbour",
            "Ratio of density",
            "Rectification"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "China Metrology Administration(China Metrology Administration),Beijing,China"
            },
            {
                "name": "Wei Hou",
                "org": "National Climate Center Beijing(National Climate Center),Beijing,China"
            },
            {
                "name": "Guolin Feng",
                "org": "National Climate Center Beijing(National Climate Center),Beijing,China"
            }
        ],
        "venue": "Jisuan Wuli/Chinese Journal of Computational Physics",
        "year": 2011
    },
    "OUgssD6N": {
        "id": "OUgssD6N",
        "title": "A Study of the Characteristics of the Cluster Extreme Events in China",
        "abstract": "Based on a comprehensive review for the spatial point theory,the method of k-order nearest-distance is combined with cluster events in order to analyze the characteristic of cluster extreme events in China. Decadal cluster index is defined to access interdecadal spatial variability and it is divided into the first and second high values in order to access the areas which have strong cluster extreme events. The results show that the spatial distribution has large difference between the 1960s and 1970s for extreme high-temperature events. The reinforcement of the cluster index of the extreme low-temperature events in the 1970s may have major activity on the chilling decadal background. The definition of the downpour is the probably reason that the area of high value of the cluster index about downpour centralize in the southern part of China. Strong precipitation is unanimous of the existing decadal variability.",
        "keywords": [
            "episodes of extreme rainfall",
            "extreme temperature event",
            "cluster",
            "decadal cluster index"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": " Institute of Urban Meteorological,China Meteorological Administration,Beijing ; Laboratory for Climate Studies,China Meteorological Administration,Beijing "
            },
            {
                "name": "HOU Wei",
                "org": " Laboratory for Climate Studies,China Meteorological Administration,Beijing "
            },
            {
                "name": "FENG Guolin",
                "org": " Laboratory for Climate Studies,China Meteorological Administration,Beijing ; College of Global Change and Earth System,Beijing Normal University,Beijing "
            }
        ],
        "venue": "Climatic and Environmental Research",
        "year": 2010
    },
    "8XujqZQu": {
        "id": "8XujqZQu",
        "title": "Cluster Extreme Events Based on Point Process Theory",
        "abstract": "Extreme weather and climate events have attracted more attention in the last few years due to the often large loss of human life and exponentially increasing costs coping with them.The assessment of extreme climate events has found that extreme events are showing the characteristic of clustering.Many natural phenomena manifest themselves as spatial point processes which produce numerous events in space, such as extreme events.For clarification,the occurrence of a phenomenon located at a single point is defined as an event in contrast to a simple geometric point.Some events assemble in a restricted region while other events are dispersed.Regarding extreme events as spatial point processes and the cluster events as the clustered points,a method is developed to delineate the cluster events from a region which is called k-th order nearest-distance spatial point method.By combining spatial point theory with cluster events,the algorithm is validated with a new method which consists of four major steps.The first step is to define different kinds of extreme events including 12 kinds of extreme temperature events and 6 kinds of extreme precipitation events.The second step is to calculate the statistically weights of every station based on the frequency and strength.The third step is to give the spatial distributions of all the stations that extreme events happens and the last step is to pick out the clustered events combining the spatial theory.Based on this method,extreme events research in eastern and middle areas of China have been accomplished,including extreme temperature events and extreme precipitation events.Results of k-th order nearest-distance, the material definitions of weights and the distribution charts are given,which can detect cluster extreme events effectively.Based on the given charts and two efficient indexes(one is called average of ratio which is represented by(?),the other is called efficiency represented by\u03b7),all kinds of extreme climate events are tested to validate the method,finding out that the algorithm is fit for cluster extreme climate events,especially for heavier extreme events.The method performs better on temperature extreme events than precipitation extreme events.So it's concluded that cluster extreme events can be delineated not only by qualitative research,but also by quantitative research,which offers a new idea in extreme events researches.",
        "keywords": [
            "k-th order nearest-distance",
            "cluster",
            "extreme events",
            "cluster point"
        ],
        "authors": [
            {
                "name": "Yang Ping",
                "org": "Institute of Urban Meteorology,CMA,Beijing "
            },
            {
                "name": "Feng Guolin",
                "org": "National Climate Center,Beijing "
            },
            {
                "name": "Liu Weidong",
                "org": "Institute of Urban Meteorology,CMA,Beijing "
            },
            {
                "name": "Hou Wei",
                "org": "National Climate Center,Beijing "
            },
            {
                "name": "Sun Shupeng",
                "org": "National Climate Center,Beijing "
            }
        ],
        "venue": "Journal of Applied Meteorological Science",
        "year": 2010
    },
    "fwAwGxiG": {
        "id": "fwAwGxiG",
        "title": "The Trend and Inter-decadal Evolution of Extreme Temperature Events in Beijing Area",
        "abstract": "The trend and inter-decadal evolution of extreme temperature events in Beijing area have been investigated by using daily mean temperature data from 20 meteorological stations in recent 30 years(1978\uff5e2007).The results indicate that the trend is almost similar between Beijing observatory and the average of all stations in Beijing region.The result of inter-decadal evolution shows that the frequency of maximum temperature in the urban areas increase obviously,which is inseparably close to urban heat island.Adversely,the spatial distribution of winter minimum temperature has no obvious relation with the mean temperature in winter.",
        "keywords": [
            "extreme low-temperature",
            "extreme high-temperature",
            "Beijing region",
            "inter-decadal evolution",
            "heat island effect"
        ],
        "authors": [
            {
                "name": "Yang Ping",
                "org": "Institute of Urban Meteorology of Beijing,China Metrology Adminstration,Beijing ,China"
            },
            {
                "name": "Liu Weidong",
                "org": "Institute of Urban Meteorology of Beijing,China Metrology Adminstration,Beijing ,China"
            },
            {
                "name": "Hou Wei",
                "org": "Laboratory for Climate Studies of China Meteorological Administration,National Climate Center,Beijing ,China"
            }
        ],
        "venue": "Journal of Catastrophology",
        "year": 2011
    },
    "ZtJmDSow": {
        "id": "ZtJmDSow",
        "title": "Heat Island Effect and Diurnal Temperature Range in Beijing Area",
        "abstract": "The K-means clustering method was used to determine quality-controlled hourly surface air temperature data of 123 automatic weather stations in the Beijing area. The sites of these stations were classified into the following four zones, that is urban stations, suburban stations, west and north mountainous area stations, and southwest and northeast mountainous area stations. Monthly and diurnal temperature variations and diurnal temperature range (DTR) of the four zones were analyzed and hourly and monthly urban heat islands were investigated. K-means clustering proved advantageous in classifying temperature zones, which were correlated with the terrain and underlying surfaces of the stations. The DTR of the urban zone was revealed to be smaller than that in suburban and mountainous areas. The west and north mountainous areas exhibited the highest DTR values. All zones exhibited high DTR values in February, May, and October. The urban heat island effect in the Beijing area was stronger in winter and at night. In the daytime, the urban heat island effect appeared to be stronger in summer than that in other seasons. From March to August, the urban heat island effect was the weakest.",
        "keywords": [
            "Automatic weather station",
            "Diurnal temperature range",
            "Clustering analysis",
            "Urban heat island"
        ],
        "authors": [
            {
                "name": "LIU Weidong",
                "org": " Institute of Urban Meteorology, China Meteorological Administration, Beijing "
            },
            {
                "name": "YANG Ping",
                "org": " Institute of Urban Meteorology, China Meteorological Administration, Beijing "
            },
            {
                "name": "YOU Huanling",
                "org": " Beijing Meteorological Bureau, Beijing "
            },
            {
                "name": "ZHANG Benzhi",
                "org": " Beijing Meteorological Bureau, Beijing "
            }
        ],
        "venue": "Climatic and Environmental Research",
        "year": 2013
    },
    "L7FJVoXq": {
        "id": "L7FJVoXq",
        "title": "Stochastially re-sorting detrended fluctuation analysis: A new method to define the threshold of extreme event",
        "abstract": "By combining detrended fluctuation analysis (DFA) method with surrogate data method, and using the Heuristic segmentation algorithm as well as Chi-Square statistics, we develop a new method to determine the threshold of extreme events, e. g. stochastically re-sorting detrended fluctuation analysis (S-DFA) method. The S-DFA method has a certain phsical background, when the occurrence rate of the data is small, then these data belong to little-probability events and they contain so little information about the dynamic system, the states corresponding to these data are abnormal states or extreme states of the system. When the occurrence rate of the data is large or even in distribution these data do not belong to little-probability events and they contain much information about the system, the states corresponding to these data are normal states of the system. Compared with the Percentile curves method, the S-DFA method gives the critical value between extreme event and non-extreame event, which is definite and unique. We also extensively validate the effectiveness of S-DFA method through extreme event detection. \u00a9 2011 Chinese Physical Society.",
        "keywords": [
            "Detrended fluctuation analysis",
            "Extreme event",
            "Surrogate data",
            "Threshold"
        ],
        "authors": [
            {
                "name": "Wei Hou",
                "org": "National Climate Center Beijing(National Climate Center),Beijing,China"
            },
            {
                "name": "Da Quan Zhang",
                "org": "National Climate Center Beijing(National Climate Center),Beijing,China"
            },
            {
                "name": "Yun Zhou",
                "org": "National Climate Center Beijing(National Climate Center),Beijing,China"
            },
            {
                "name": "Ping Yang",
                "org": "China Metrology Administration(China Metrology Administration),Beijing,China"
            }
        ],
        "venue": "Wuli Xuebao/Acta Physica Sinica",
        "year": 2011
    },
    "BVVFeFLE": {
        "id": "BVVFeFLE",
        "title": "The Climatic Change Trend and Seasonal Characteristics of Daily Temperature Extremes in China for the Latest 40 Years",
        "abstract": "Extreme events have heavy negative effects on the society causing great economic loss so they have attracted much attention.Using maximal/minimum daily temperature data from 194 stations for the period of 1961\u20142000 of China and adopting indices of extreme climate,seasonal characteristics and the changes of daily temperature extremes are analyzed.The indices of temperature extremes are introduced concluding absolute and relative definition.Then the annual indices of hot and cold extreme events are discussed.In order to compare the differences of the indices among different seasons,the season indices are also researched.The results indicate the hot extreme indices and cold extreme indices defined by absolute threshold show the trend of summer and winter,but the result of absolute annual indices of temperature extremes is not satisfying because the differences between southern and northern are not considered.Another indices based on the percentage definitions indicate that cold and hot extremes indices are anisomerous.Hot days and cold days are not consistent and the indices in same area between hot days and cold days are not symmetrical.But indices for hot nights and cold nights show good consistency and symmetry.The indices change little for daytime but change rapidly at night.The indices of seasonal temperature extremes show that the changes of indices in spring and autumn are most indistinctive,while the indices in winter is the most notable.The cold indices of spring,autumn and winter are decreasing while trends of summer indices are increasing most of the time.",
        "keywords": [
            "warming",
            "change trend",
            "indices of temperature extremes",
            "seasonal characteristics"
        ],
        "authors": [
            {
                "name": "Yang Ping",
                "org": "Institute of Urban Meteorology of Beijing,China Meteorological Administration,Beijing "
            },
            {
                "name": "Liu Weidong",
                "org": "Institute of Urban Meteorology of Beijing,China Meteorological Administration,Beijing "
            },
            {
                "name": "Wang Qiguang",
                "org": "Lanzhou University,Lanzhou "
            },
            {
                "name": "Xiong Kaiguo",
                "org": "Lanzhou University,Lanzhou "
            },
            {
                "name": "Hou Wei",
                "org": "National Climate Center,Beijing "
            }
        ],
        "venue": "Journal of Applied Meteorological Science",
        "year": 2010
    },
    "LYaoOe9L": {
        "id": "LYaoOe9L",
        "title": "A valid method to compute the segment size in detrended fluctuation analysis",
        "abstract": "We develop a method to compute the segment size in the detrended fluctuation analysis (DFA), which is based on the basic concept of the information theory, and verify the method effectiveness by numerical experiment. This method is freed from the problem of subjectivity in the former process to choose the segment size which usually leads to false result. We Change the length of sequence with dynamics being the same, the results remain stable. The results indicate that when the length of sequence is too short, even the optimal selection of segment size is not enough for the portrait of the overall dynamic system, thus the DFA cannot be used in this circumstance. The method we developed in this paper can enhance the reliability of DFA results by judging whether the sequences analyzed meet the requirements of DFA. We also obtain the DFA index from 1961 to 2000 of China through DFA method and analyze its spatial characteristics of distribution. \u00a9 2010 Chin. Phys. Soc.",
        "keywords": [
            "Detrended fluctuation analysis",
            "Optimal selection",
            "Parameter selection",
            "Segment"
        ],
        "authors": [
            {
                "name": "Wei Hou",
                "org": "National Climate Center Beijing(National Climate Center),Beijing,China"
            },
            {
                "name": "Da Quan Zhang",
                "org": "National Climate Center Beijing(National Climate Center),Beijing,China"
            },
            {
                "name": "Ping Yang",
                "org": "China Meteorological Administration(China Meteorological Administration,CMA),Beijing,China"
            },
            {
                "name": "Jie Yang",
                "org": "National Climate Center Beijing(National Climate Center),Beijing,China"
            }
        ],
        "venue": "Wuli Xuebao/Acta Physica Sinica",
        "year": 2010
    },
    "WsCPM0LI": {
        "id": "WsCPM0LI",
        "title": "Research Advances in the Effect of Urban Heat Island",
        "abstract": "Urban climate is a special regional climate,which results from the local climate circulation and human activities. Urbanization makes cities more and more vulnerable to the meteorological environment and natural disasters.Therefore,research on urban climate is very important to city development and its safety.A basic theory and science research in urban climate is reviewed in the paper.The hot topics and recent advances in the urban climate field are also discussed.Based on the review and discussion,some suggestions are given for the future urban climate.",
        "keywords": [
            "research advances",
            "urban climate",
            "urbanize"
        ],
        "authors": [
            {
                "name": "Yang Ping",
                "org": "1 CMA Training Center,China Meteorological Administration,Beijing  ;2 Institute of Urban Meteorology, China Meteorological Administration,Beijing "
            },
            {
                "name": "Liu Weidong",
                "org": "2 Institute of Urban Meteorology, China Meteorological Administration,Beijing "
            }
        ],
        "venue": "Advances in Meteorological Science and Technology",
        "year": 2012
    },
    "mhV0HL5a": {
        "id": "mhV0HL5a",
        "title": "Determining the threshold of extreme events with detrended fluctuation analysis",
        "abstract": "When the dynamic system is in the extreme states, or it is affected by an intensive disturbance, we will get an extreme event. The detrended fluctuation analysis (DFA) measures the long-term correlation of a system, so the extreme events has no effect on system's long-term correlation. Based on this idea, we determined the threshold of extreme events with detrended fluctuation analysis and the results testify its effectiveness. By this method, we analyzed the extreme events in Beijing for the temperature and rain. The results show that before the metaphase of the 1970s, the frequency and intensity of the extreme temperature events is mitigatory, and from 1970s to 1990s, there were very few extreme events. But from the metaphase of the 1990s to now, the extreme temperature events are frequent. The extreme low temperature event has a downtrend from the 1950s to now and never happened after 1978s. The frequency and intensity of extreme precipitations are periodic. The frequency and intensity were high in the metaphase of 1950s and 1960s, and were low in the remaining period. The transition occurred in the 1970s.",
        "keywords": [
            "Detrended fluctuation analysis",
            "Extreme event",
            "Threshold"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Wei Hou",
                "org": "Lanzhou University(Lanzhou University),Lanzhou,China"
            },
            {
                "name": "Feng Guo-Lin",
                "org": "Institute of Atmospheric Physics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Atmospheric Physics),Beijing,China"
            }
        ],
        "venue": "Wuli Xuebao/Acta Physica Sinica",
        "year": 2008
    },
    "xgSF20Pr": {
        "id": "xgSF20Pr",
        "title": "The characteristics of clusters of weather and extreme climate events in China during the past 50 years",
        "abstract": "The pick-up algorithm by the k-th order cluster for the closest distance is used in the fields of weather and climactic events, and the technical terms clustered index and high clustered region are defined to investigate their temporal and spatial distribution characteristics in China during the past 50 years. The results show that the contribution of extreme high-temperature event clusters changed in the period from the 1960s to the 1970s, and its strength was enhanced. On the other hand, the decreasing trend in the clusters of low-temperature extremes can be taken as a signal for warmer winters to follow in the decadal time scale. Torrential rain and heavy rainfall clusters have both been lessened in the past 50 years, and have different cluster characteristics because of their definitions. Regions with high clustered indexes are concentrated in southern China. The spatial evolution of the heavy rainfall clusters reveals that clustered heavy rainfall has played an important role in the rain-belt pattern over China during the last 50 years. \u00a9 2012 Chinese Physical Society and IOP Publishing Ltd.",
        "keywords": [
            "clusters",
            "decadal clustered index",
            "extreme event"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "China Metrology Administration(China Metrology Administration),Beijing,China"
            },
            {
                "name": "Wei Hou",
                "org": "China Meteorological Administration(China Meteorological Administration,CMA),Beijing,China"
            },
            {
                "name": "Feng Guo-Lin",
                "org": "China Meteorological Administration(China Meteorological Administration,CMA),Beijing,China"
            }
        ],
        "venue": "Chinese Physics B",
        "year": 2012
    },
    "JLBf8Bma": {
        "id": "JLBf8Bma",
        "title": "Characteristics of spatiotemporal distribution of extreme temperature events over China mainland in different climate states against the backdrop of most probable temperature",
        "abstract": "Daily max temperature records of National Meteorological Information Center from 1961 to 2009 over China mainland are divided into three climate states of 1961-1990, 1971-2000, 1981-2009 (just called State I, State II, State III respectively). Most probable temperature(MPT) and extreme temperature events are defined according to the skewed function. The spatiotemporal distribution characteristics of frequency and strength of extreme temperature events over China mainland in different climate sates against the backdrop of MPT are analyzed. Spatially, frequency and strength of extremly high temperature in summer decrease significantly in the Yangtze-Huaihe river valley and the Yellow river and Huaihe River valley in State I and increase significantly in the arid-semiarid region and the econormically developed Yangtze River delta in State III. The frequency of extremely low temperature in winter reduces remarkably in the north part and the Yangtze River delta in State II and in the Qinghai-Tibet Plateau, the southeast part of northeast China, the Yangtze River delta in State III. The strength of extremely low temperature in winter reduces on the whole and provincial characteristics are not obvious. The frequency and the strength of extreme temperature events are consistont spatially. Temporally, the frequency and the strength of extremely high temperature in summer increase obviously both in State II and State III. The frequency and the strength of extremely low temperature in winter reduce obviously in State II and the reducing trend slows down in State III. Extremely high temperature in summer occurs frequently and extremely low temperature in winter remains stable. Extremity of high temperature in summer is stronger while in winter is stable relatively. The frequency and the strength of extreme temperature events are consistent temporally. During the common time period of States I, II and III, the frequency of extremely high temperature events in the last state was always less than the former while the low temperature events are more, which is in accordance with the fact that the background temperature steps up with the states; the strength of extremely high temperature events in the latter state is less than that of the former while the strength of extremely low temperature events is stronger. For the abrupt change of climate at the end of the 1970 s and the beginning of the 1980 s, the frequency of extreme high temperature events decreases before the change and increases obviously after the change while the ones of extremely low temperature do not change significantly correspondingly; the strength of extremely high temperature events decreassd slightly before the change and increases obviously after the change while the strength of extremely low temperature does not change significantly for the change but the whole strength after the change is slightly lower than the one before the change. \u00a9 2011 Chinese Physical Society.",
        "keywords": [
            "Climate states",
            "Extreme high temperature",
            "Extreme low temperature"
        ],
        "authors": [
            {
                "name": "Qian Zhong-Hua",
                "org": "Yangzhou University(Yangzhou University),Yangzhou,China"
            },
            {
                "name": "Wei Hou",
                "org": "National Climate Center Beijing(National Climate Center),Beijing,China"
            },
            {
                "name": "Ping Yang",
                "org": "China Metrology Administration(China Metrology Administration),Beijing,China"
            },
            {
                "name": "Feng Guo-Lin",
                "org": "Yangzhou University(Yangzhou University),Yangzhou,China"
            }
        ],
        "venue": "Wuli Xuebao/Acta Physica Sinica",
        "year": 2011
    },
    "FI2u9HSU": {
        "id": "FI2u9HSU",
        "title": "Quadratic boost power factor correction converters with small input inductor current ripple",
        "abstract": "To reduce the input inductor current ripple and EMI of boost power factor correction (PFC) converters, the quadratic boost converter is utilized to realize PFC in this paper. The operation modes of quadratic boost PFC converters are discussed. When the input inductor operates in a continuous conduction mode (CCM), according to the operating mode (CCM and (discontinuous conduction mode, DCM)) of the storage inductor, the CCM quadratic boost PFC converter can be divided into a CCM-CCM quadratic boost PFC converter and a CCM-DCM (discontinuous conduction mode) quadratic boost PFC converter. The input inductor current ripple and the range of duty ratio of the CCM quadratic boost PFC converter and the CCM boost PFC converter under different AC input voltages are analyzed. Compared with the CCM boost PFC converter, the CCM quadratic boost PFC converter has smaller input inductor current ripple and variation range of duty ratio. The correctness of theoretical analysis is validated by simulations and experiments. \u00a9 2013 Chin. Soc. for Elec. Eng.",
        "keywords": [
            "Electromagnetic interference (EMI)",
            "Input inductor current ripple",
            "Power factor correction (PFC)",
            "Quadratic Boost converter",
            "Range of duty ratio"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "Southwest Jiaotong University(Southwest Jiaotong University,Southwest Jiaotong Univ.),Chengdu,China"
            },
            {
                "name": "Jianping Xu",
                "org": "Southwest Jiaotong University(Southwest Jiaotong University,Southwest Jiaotong Univ.),Chengdu,China"
            },
            {
                "name": "Zheng Dong",
                "org": "Southwest Jiaotong University(Southwest Jiaotong University,Southwest Jiaotong Univ.),Chengdu,China"
            },
            {
                "name": "Fei Zhang",
                "org": "Southwest Jiaotong University(Southwest Jiaotong University,Southwest Jiaotong Univ.),Chengdu,China"
            },
            {
                "name": "Shiyu Zhang",
                "org": "Southwest Jiaotong University(Southwest Jiaotong University,Southwest Jiaotong Univ.),Chengdu,China"
            }
        ],
        "venue": "Zhongguo Dianji Gongcheng Xuebao/Proceedings of the Chinese Society of Electrical Engineering",
        "year": 2013
    },
    "de29RFoX": {
        "id": "de29RFoX",
        "title": "Research on Quadratic Boost PFC Converter With Small Inductor Current Ripple",
        "abstract": "Due to large input inductor current ripple and wide duty cycle variation range of traditional Boost power factor correction(PFC) converter,a quadratic Boost PFC converter is presented.The working principle of quadratic Boost PFC converter is studied.The input inductor current ripple and duty cycle are analyzed.The results of the study show that the input inductor current ripple of quadratic Boost PFC converter is smaller than that of traditional Boost PFC converter,that would help to design EMI filter,and the duty cycle is smaller,that would reduce the difficulty of controller design.The average current mode control of quadratic Boost PFC converter simulation model is designed.The experimental results show that the input inductor current of the quadratic Boost PFC converter is sinusoidal and the inductor current ripple is evidently smaller than that of traditional Boost PFC converter.Prototype experiments prove the validity of the theoretical analysis.",
        "keywords": [
            "power factor correction",
            "quadratic",
            "converter",
            "inductor current ripple"
        ],
        "authors": [
            {
                "name": "DONG Zheng",
                "org": ""
            },
            {
                "name": "XU Jian-ping",
                "org": ""
            },
            {
                "name": "ZHANG Fei",
                "org": ""
            },
            {
                "name": "YANG Ping",
                "org": ""
            }
        ],
        "venue": "Power Electronics",
        "year": 2013
    },
    "79sVJ9I0": {
        "id": "79sVJ9I0",
        "title": "Design of Four Quadrant Pulse Rectifier Based on Composite Phase-locked Loop",
        "abstract": "The design of four quadrant pulse rectifier for the traction drive system of electric power locomotive is introduced.The principles and instantaneous direct current control strategy of four quadrant pulse rectifier are discussed.Compared with hardware phase-locked loop and software phase-locked loop,a combination of hardware and software composite phase-locked loop is proposed,which can accurately track the phase of line voltage.Effects of the grid voltage disturbance on the rectifier DC output voltage are analyzed,when the grid voltage disturbances in 10%,DC output voltage reaches steady state rapidly after the small fluctuations.The experimental results show that the input current of pulse rectifier has strong anti-interference ability,and can accurately follow the input voltage to achieve high power factor close to 1.",
        "keywords": [
            "rectifier",
            "instantaneous direct current control",
            "composite phase-locked loop"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Southwest Jiaotong University,Chengdu ,China"
            },
            {
                "name": "XU Jian-ping",
                "org": "Southwest Jiaotong University,Chengdu ,China"
            },
            {
                "name": "ZHANG Fei",
                "org": "Southwest Jiaotong University,Chengdu ,China"
            },
            {
                "name": "DAI Yun-zhong",
                "org": "Southwest Jiaotong University,Chengdu ,China"
            }
        ],
        "venue": "Power Electronics",
        "year": 2010
    },
    "gcLGIWaA": {
        "id": "gcLGIWaA",
        "title": "A Filter Algorithm to Improve the Dynamic Response Performance of PFC Converter",
        "abstract": "The single-phase boost PFC converter with conventional low-bandwidth voltage loop exhibits poor dynamic response.A filter algorithm is presented to improve the dynamic performance of the this converter.The low-frequency ripple at the output of the voltage controller is filtered out by using the proposed filter algorithm.The converter can achieve a high bandwidth of the voltage control loop while maintaining a high power factor,thus resulting in fast response.The algorithm is verified by experimental results from a DCM Boost PFC converter.",
        "keywords": [
            "power factor correction",
            "converter",
            "dynamic response performance"
        ],
        "authors": [
            {
                "name": "YU Hai-kun",
                "org": "Southwest Jiaotong University,Chengdu ,China"
            },
            {
                "name": "XU Jian-ping",
                "org": "Southwest Jiaotong University,Chengdu ,China"
            },
            {
                "name": "ZHANG Fei",
                "org": "Southwest Jiaotong University,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Southwest Jiaotong University,Chengdu ,China"
            }
        ],
        "venue": "Power Electronics",
        "year": 2010
    },
    "lJw70tat": {
        "id": "lJw70tat",
        "title": "Research of Four-quadrant Converter Based on Predictive Current Control",
        "abstract": "A MATLAB simulation method was introduced to realize the predictive current control of 4 quadrant converter.Analysis of the dynamic response under traction condition and regeneration condition were performed.A prototype based on TMS320F2812 was built to verify the performance of the control scheme.Simulation and experiment results show that the harmonics are suppressed effectively and unity power factor can be achieved by using the control scheme.System has good dynamic and static characteristics.",
        "keywords": [
            "4 quadrant converter",
            "predictive current control",
            "power factor",
            "digital signal processor"
        ],
        "authors": [
            {
                "name": "DAI Yun-zhong",
                "org": "School of Electrical Engineering,Southwest Jiaotong University,Chengdu,Sichuan ,China"
            },
            {
                "name": "XU Jian-ping",
                "org": "School of Electrical Engineering,Southwest Jiaotong University,Chengdu,Sichuan ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Electrical Engineering,Southwest Jiaotong University,Chengdu,Sichuan ,China"
            },
            {
                "name": "ZHANG Fei",
                "org": "School of Electrical Engineering,Southwest Jiaotong University,Chengdu,Sichuan ,China"
            }
        ],
        "venue": "Electric Drive for Locomotives",
        "year": 2010
    },
    "8YoFOO83": {
        "id": "8YoFOO83",
        "title": "Dynamics of current controlled switching converters under wide circuit parameter variation",
        "abstract": "With current-controlled buck-boost converter used as an example, through a detailed description of the switch state of the switching converter under wide circuit parameter variation, such as input voltage and load resistance variation, two inductor current borders in the current controlled switching converter are derived and an accurate discrete-time model is established. The validation of the discrete-time model is verified by a piecewise-linear model. Based on the discrete-time model, the complex dynamical behaviors existing in switching converter, such as period-double bifurcation, border-collision bifurcation, robust chaos and intermittent chaos, etc., are revealed. By formulating the Jacobian, the maximum Lyapunov exponent and the movement trajectories of eigvalues with the variations of circuit parameters are obtained. By utilizing the parameter-space maps, the operation-state regions corresponding to circuit parameter regions are estimated. Finally, an experimental setup is implemented, the corresponding observation results are consistent with those of theory analyses. In this paper the dynamics theory in switching converters is investigated systematically; the analysis methods and research results are helpful for designing and controlling switching converters.",
        "keywords": [
            "discrete-time model",
            "border-collision bifurcation",
            "switching converter",
            "current control"
        ],
        "authors": [
            {
                "name": "Bao Bo-Cheng",
                "org": " School of Information Science and Engineering, Changzhou University, Changzhou , China "
            },
            {
                "name": "Yang Ping",
                "org": " School of Electrical Engineering, Southwest Jiaotong University, Chengdu , China "
            },
            {
                "name": "Ma Zheng-Hua",
                "org": " School of Information Science and Engineering, Changzhou University, Changzhou , China "
            },
            {
                "name": "Zhang Xi",
                "org": " School of Information Science and Engineering, Changzhou University, Changzhou , China "
            }
        ],
        "venue": "Acta Physica Sinica",
        "year": 2012
    },
    "9HU4OL1B": {
        "id": "9HU4OL1B",
        "title": "Research on a new single-switch high gain Boost converter",
        "abstract": "In this paper,a hybrid topology that combining single-switch quadratic boost converter and voltage lift technique is proposed,and the proposed converter provides high voltage gain and reduced switching voltage stress,and is suitable for application of wide input voltage.The working principle of the new single-switch high gain boost converter is analyzed in this paper.The steady state characteristics of the converter and relationship among circuit parameters are studied.Compared with quadratic boost converter,the switch voltage stress of proposed converter is lower,which enables to use MOSFET switch with lower voltage and on-resistance to reduce costs as well as switching and conduction losses.Simulation and experimental results are presented to verify the theoretical analysis.",
        "keywords": [
            "voltage-lift-technique",
            "DC-DC converter",
            "steady state characteristics",
            "high gain Boost converter"
        ],
        "authors": [
            {
                "name": "ZHANG Shi-yu",
                "org": "College of Electrical Engineering,Southwest Jiaotong University,Chengdu ,China"
            },
            {
                "name": "XU Jian-ping",
                "org": "College of Electrical Engineering,Southwest Jiaotong University,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Electrical Engineering,Southwest Jiaotong University,Chengdu ,China"
            }
        ],
        "venue": "Advanced Technology of Electrical Engineering and Energy",
        "year": 2013
    },
    "PAhia663": {
        "id": "PAhia663",
        "title": "Transient Current Control of Four Quadrant Converter Based on DSP",
        "abstract": "A Matlab simulation method is introduced to realize the transient current control of four quadrant converter and its mathematical mode is established.Analysis the dynamic response,traction condition and regeneration condition are performed.A prototype based on TMS320F2812 is built to verify the performance of the control scheme.The simulation and experimental results show that the harmonic is restrained effectively and power factor correction can be achieved by using the control scheme.",
        "keywords": [
            "power factor correction",
            "converter",
            "transient current control",
            "digital signal processor"
        ],
        "authors": [
            {
                "name": "DAI Yun-zhong",
                "org": "Southwest Jiaotong University,Chengdu ,China"
            },
            {
                "name": "XU Jian-ping",
                "org": "Southwest Jiaotong University,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Southwest Jiaotong University,Chengdu ,China"
            },
            {
                "name": "ZHANG Fei",
                "org": "Southwest Jiaotong University,Chengdu ,China"
            }
        ],
        "venue": "Power Electronics",
        "year": 2010
    },
    "Ys1gVxLV": {
        "id": "Ys1gVxLV",
        "title": "Dynamics of current controlled quadratic boost converters",
        "abstract": "The two inductor current boundaries are derived, and segmented smooth iteration mapping model of current controlled quadratic boost converter is established based on the detailed description of switching states. The comparative analyses of the nonlinear bifurcation behaviors are performed with input inductor current and the storage inductor current as current feedback respectively. Two boundary conditions for the transition from stable period-one state to sub-harmonic oscillation state and for the transition from discontinuous conduction mode to continuous conduction mode are derived by analyzing stability and operation mode. The operation-state regions corresponding to circuit parameter regions are estimated by utilizing the parameter-space maps. An experimental circuit is built and the results show that both different bifurcation routes and operation mode transition phenomenon are changed with parameter variation, the current controlled quadratic boost converter exhibits complicated dynamical behaviors. The experimental results verify the correctness of the theoretical analysis.",
        "keywords": [
            "quadratic boost converter",
            "border-collision bifurcation",
            "switching state",
            "mode shift"
        ],
        "authors": [
            {
                "name": "Yang Ping",
                "org": " Key Laboratory of Magnetic Suspension Technology and Maglev Vehicle, Ministry of Education, School of Electrical Engineering, Southwest Jiaotong University, Chengdu , China "
            },
            {
                "name": "Xu Jian-Ping",
                "org": " Key Laboratory of Magnetic Suspension Technology and Maglev Vehicle, Ministry of Education, School of Electrical Engineering, Southwest Jiaotong University, Chengdu , China "
            },
            {
                "name": "He Sheng-Zhong",
                "org": " Key Laboratory of Magnetic Suspension Technology and Maglev Vehicle, Ministry of Education, School of Electrical Engineering, Southwest Jiaotong University, Chengdu , China "
            },
            {
                "name": "Bao Bo-Cheng",
                "org": " School of Information Science and Engineering, Changzhou University, Changzhou , China "
            }
        ],
        "venue": "Acta Physica Sinica",
        "year": 2013
    },
    "cSIMpgQs": {
        "id": "cSIMpgQs",
        "title": "Dynamical mechanism of ramp compensation for switching converter",
        "abstract": "By introducing ramp compensation current into the feedback control circuit of current controlled switching DC-DC converter it can not only effectively extend the stable operation range of the switching DC-DC converter to realize chaotic stability control, but also shift its operation mode from discontinuous conduction mode to continuous conduction mode to realize operation mode shift. Taking current-controlled buck-boost converter as example by establishing the two-dimensional discrete-time model and the corresponding Jacobian matrix of current-controlled buck-boost converter with ramp compensation and two inductor current borders, the dynamical mechanism of ramp compensation for switching DC-DC converter is investigated. By analyzing the conditions of the instability and border collision bifurcation, the effects of the ramp compensation on the stable period oscillation and operation mode shift of switching DC-DC converter are discussed, and the corresponding stability boundary and mode shift boundary are obtained. Finally, an experimental circuit is built and the results are observed, from which the physical significance of the ramp compensation for chaotic stability control and operation mode shift of switching DC-DC converter is illustrated and the correctness of theoretical analysis is verified.",
        "keywords": [
            "stability control",
            "ramp compensation",
            "mode shift",
            "buck-boost converter"
        ],
        "authors": [
            {
                "name": "Yang Ping",
                "org": "School of Electrical Engineering, Southwest Jiaotong University, Chengdu , China"
            },
            {
                "name": "Bao Bo-Cheng",
                "org": "School of Information Science and Engineering, Changzhou University, Changzhou , China"
            },
            {
                "name": "Sha Jin",
                "org": "School of Electrical Engineering, Southwest Jiaotong University, Chengdu , China"
            },
            {
                "name": "Xu Jian-Ping",
                "org": "School of Electrical Engineering, Southwest Jiaotong University, Chengdu , China"
            }
        ],
        "venue": "Acta Physica Sinica",
        "year": 2013
    },
    "jpBqIG2U": {
        "id": "jpBqIG2U",
        "title": "Equivalent modeling and bifurcation analysis of V~2 controlled buck converter",
        "abstract": "After dimension reduction, two boundary voltages of V 2 controlled buck converter are deduced under different operation mode, based on which, its equivalent one-dimensional discrete-time model is established and complex nonlinear bifurcation behaviors are emphatically studied. Two boundary conditions under which shift between stable period-one state and subharmonic oscillation state and shift between continuous conduction mode (CCM) and discontinuous conduction mode (DCM) take place are derived by analyzing stability and operation mode. The research results show that in V2 controlled buck converter period-doubling bifurcation and bordercollision bifurcation can occur with varying circuit parameters and the converter has different bifurcation routes at different circuit parameters. Simulation and experiment platforms are implemented and the corresponding results verify the validity of equivalent discrete-time model and theoretical analysis.",
        "keywords": [
            "iterative model",
            "V2 control",
            "operation mode",
            "bifurcation"
        ],
        "authors": [
            {
                "name": "He Sheng-Zhong",
                "org": " School of Electrical Engineering, Southwest Jiaotong University, Chengdu , China "
            },
            {
                "name": "Zhou Guo-Hua",
                "org": " School of Electrical Engineering, Southwest Jiaotong University, Chengdu , China "
            },
            {
                "name": "Xu Jian-Ping",
                "org": " School of Electrical Engineering, Southwest Jiaotong University, Chengdu , China "
            },
            {
                "name": "Bao Bo-Cheng",
                "org": " School of Information Science and Engineering, Changzhou University, Changzhou , China "
            },
            {
                "name": "Yang Ping",
                "org": " School of Electrical Engineering, Southwest Jiaotong University, Chengdu , China "
            }
        ],
        "venue": "Acta Physica Sinica",
        "year": 2013
    },
    "rQ07bCXr": {
        "id": "rQ07bCXr",
        "title": "Single-switch quadratic DCM buck converter",
        "abstract": "The single-switch quadratic converters realize the cascade of two converters with only one active switch to achieve wider voltage conversion ratios and a better efficiency with simple driver circuits. Compared with traditional Buck converter, the single-switch quadratic Buck converter has three work conditions in discontinuous conduction mode (DCM). In this paper, the working principle of the converter is analyzed. The state space averaging model of the converter is established. The steady state characteristics of the converter and relationship among circuit parameters are studied. Simulation and experimental results are presented to verify the theoretical analysis.",
        "keywords": [
            "Discontinuous conduction mode",
            "Single-switch quadratic Buck converter",
            "Steady state characteristics",
            "Voltage conversion ratios"
        ],
        "authors": [
            {
                "name": "Zhifei Lu",
                "org": "Southwest Jiaotong University(Southwest Jiaotong University,Southwest Jiaotong Univ.),Chengdu,China"
            },
            {
                "name": "Ping Yang",
                "org": "Southwest Jiaotong University(Southwest Jiaotong University,Southwest Jiaotong Univ.),Chengdu,China"
            },
            {
                "name": "Xueshan Liu",
                "org": "Southwest Jiaotong University(Southwest Jiaotong University,Southwest Jiaotong Univ.),Chengdu,China"
            },
            {
                "name": "Jianping Xu",
                "org": "Southwest Jiaotong University(Southwest Jiaotong University,Southwest Jiaotong Univ.),Chengdu,China"
            }
        ],
        "venue": "Diangong Jishu Xuebao/Transactions of China Electrotechnical Society",
        "year": 2011
    },
    "wYOefE5s": {
        "id": "wYOefE5s",
        "title": "Two-switch pseudo continuous conduction mode buck-boost power factor correction converter",
        "abstract": "A novel two-switch Buck-Boost power factor correction (PFC) converter operating in pseudo continuous conduction mode (PCCM) and its corresponding control strategy were proposed in this paper. The two-switch PCCM Buck-Boost PFC topology provides an additional degree of control freedom to realize PFC control, which can offer significant performance improvements over single-switch Buck-Boost PFC converters or two-switch Buck-Boost PFC converters in continuous conduction mode (CCM) and discontinuous conduction mode (DCM). The additional degree of control freedom introduced by inductor current freewheeling stage helps to achieve unity power factor control. Besides, inductor current ripple of the two-switch PCCM Buck-Boost PFC converter, which is lower than that of the two-switch DCM Buck-Boost PFC converter, can be obtained. Analysis, simulation and experiment results of the two-switch PCCM Buck-Boost PFC converter were presented. The experiment results show that the dynamic response of the two-switch PCCM Buck-Boost PFC converter is significantly faster than that of the two-switch CCM and DCM Buck-Boost PFC converter. \u00a9 2012 Chinese Society for Electrical Engineering.",
        "keywords": [
            "Dynamic response",
            "Low inductor current ripple",
            "Power factor correction (PFC)",
            "Pseudo continuous conduction mode (PCCM)",
            "Two-switch Buck-Boost converter"
        ],
        "authors": [
            {
                "name": "Fei Zhang",
                "org": "Southwest Jiaotong University(Southwest Jiaotong University,Southwest Jiaotong Univ.),Chengdu,China"
            },
            {
                "name": "Jianping Xu",
                "org": "Southwest Jiaotong University(Southwest Jiaotong University,Southwest Jiaotong Univ.),Chengdu,China"
            },
            {
                "name": "Ping Yang",
                "org": "Southwest Jiaotong University(Southwest Jiaotong University,Southwest Jiaotong Univ.),Chengdu,China"
            },
            {
                "name": "Zhangyong Chen",
                "org": "Southwest Jiaotong University(Southwest Jiaotong University,Southwest Jiaotong Univ.),Chengdu,China"
            }
        ],
        "venue": "Zhongguo Dianji Gongcheng Xuebao/Proceedings of the Chinese Society of Electrical Engineering",
        "year": 2012
    },
    "brOTvpWC": {
        "id": "brOTvpWC",
        "title": "Peak current control mode for quadratic Boost converter",
        "abstract": "Wide input voltage range of quadratic Boost converter has attracted much attention recently. Compared with conventional Boost converter, quadratic Boost converter has two LC filters, thus is a four order dynamics circuit. Peak current control mode of quadratic Boost converter with input inductor current and output capacitor voltage as feedback control variable is proposed. The proposed control scheme is simple. Experimental results show that the proposed peak current control quadratic Boost converter features with fast transient response and small output voltage ripple.",
        "keywords": [
            "Peak current control mode",
            "Quadratic Boost converter",
            "Slope compensation",
            "Wide input voltage range"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "Southwest Jiaotong University(Southwest Jiaotong University,Southwest Jiaotong Univ.),Chengdu,China"
            },
            {
                "name": "Jianping Xu",
                "org": "Southwest Jiaotong University(Southwest Jiaotong University,Southwest Jiaotong Univ.),Chengdu,China"
            },
            {
                "name": "Shiyu Zhang",
                "org": "Southwest Jiaotong University(Southwest Jiaotong University,Southwest Jiaotong Univ.),Chengdu,China"
            },
            {
                "name": "Jinping Wang",
                "org": "Southwest Jiaotong University(Southwest Jiaotong University,Southwest Jiaotong Univ.),Chengdu,China"
            }
        ],
        "venue": "Diangong Jishu Xuebao/Transactions of China Electrotechnical Society",
        "year": 2011
    },
    "PQ3RKQg3": {
        "id": "PQ3RKQg3",
        "title": "Energy transmission mode of quadratic CCM Boost converter",
        "abstract": "In order to analyze the output voltage ripple characteristics of quadratic CCM Boost converter,energy transmission modes(ETM) were discussed.According to the relation of the valley inductor current and the output current,ETM of quadratic CCM Boost converter during switch turned off were analyzed.ETM were divided into the complete inductor supply mode(CISM) and the incomplete inductor supply mode(IISM).Considering the existence of output capacitor equivalent series resistance(ESR),output voltage ripples of quadratic CCM Boost converter in both CISM and IISM were analyzed and the critical inductor and critical condition between CISM and IISM were deduced.Ignoring the existence of ESR,output voltage ripple of quadratic CCM Boost converter in CISM was determined by capacitor voltage during switch turned off and was independent of the current flowing through the inductor.While considering the existence of ESR,quadratic CCM Boost converter in CISM had smaller output voltage ripple than in IISM.A prototype quadratic CCM Boost converter was built and the experimental results verify the analysis results.",
        "keywords": [
            "equivalent series resistance",
            "quadratic boost converter",
            "energy transmission mode",
            "critical inductor",
            "output voltage ripple"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "School of Electrical Engineering,Southwest Jiaotong University,Chengdu ,China"
            },
            {
                "name": "XU Jian-ping",
                "org": "School of Electrical Engineering,Southwest Jiaotong University,Chengdu ,China"
            },
            {
                "name": "ZHANG Shi-yu",
                "org": "School of Electrical Engineering,Southwest Jiaotong University,Chengdu ,China"
            },
            {
                "name": "ZHANG Fei",
                "org": "School of Electrical Engineering,Southwest Jiaotong University,Chengdu ,China"
            }
        ],
        "venue": "Electric Machines and Control",
        "year": 2012
    },
    "98YQ0Z0Y": {
        "id": "98YQ0Z0Y",
        "title": "Analysis of Constant On-time Controlled Quadratic Buck Converter",
        "abstract": "The working principle of quadratic Buck converter is studied.Constant on-time(COT) controlled quadratic Buck converter is analyzed.The effect of the output capacitor equivalent series resistance on the control performance of COT controlled quadratic Buck converter is revealed.The critical value of the output capacitor equivalent series resistance causing pulse bursting is given.The results show that if the value of the equivalent series resistance is less than the critical value,the pulse bursting occurs and the ripple of output voltage increases.If the value of the equivalent series resistance is larger than the critical value,the pulse bursting disappears and the circuit can work well.At last,the correctness of theoretical analysis is validated by simulation and experimental results.",
        "keywords": [
            "pulse bursting",
            "equivalent series resistance",
            "converter",
            "constant on-time control"
        ],
        "authors": [
            {
                "name": "DONG Zheng",
                "org": "Southwest Jiaotong University,Chengdu ,China"
            },
            {
                "name": "WANG Jin-ping",
                "org": "Southwest Jiaotong University,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Southwest Jiaotong University,Chengdu ,China"
            },
            {
                "name": "XU Jian-ping",
                "org": "Southwest Jiaotong University,Chengdu ,China"
            }
        ],
        "venue": "Power Electronics",
        "year": 2012
    },
    "v7AfSqGR": {
        "id": "v7AfSqGR",
        "title": "Research on ultimate strength of the two-way orthogonal multi-stiffened plates",
        "abstract": "Based on the orthotropic plate theory, this paper described geometrical configuration and material orthotropic equivalent conversion for the two-way orthogonal multi-stiffened plates. Nonlinear FEM has been performed to a series of two-way orthogonal multi-stiffened plates subjected to axial compression load. Based on the numerical results and orthotropic plate theory, a proposed formula is presented for the ultimate strength prediction of two-way orthogonal multi-stiffened plates. Comparison results show that the simple and reasonable formula can forecast the ultimate strength of the two-way orthogonal multi-stiffened plates more accurately.",
        "keywords": [
            "Nonlinear FEM analysis",
            "Two-way orthogonal multi-stiffened plates",
            "Ultimate strength formula"
        ],
        "authors": [
            {
                "name": "Jidong Qiu",
                "org": "Wuhan University of Technology(Wuhan University of Technology),Wuhan,China"
            },
            {
                "name": "Ping Yang",
                "org": "Wuhan University of Technology(Wuhan University of Technology),Wuhan,China"
            }
        ],
        "venue": "Wuhan Ligong Daxue Xuebao (Jiaotong Kexue Yu Gongcheng Ban)/Journal of Wuhan University of Technology (Transportation Science and Engineering)",
        "year": 2013
    },
    "YvU7apIa": {
        "id": "YvU7apIa",
        "title": "Strength and Buckling Analysis of Ship Girders with Cutout",
        "abstract": "By the finite element method,the load bearing capacity of ship girders with cut-out under uniaxial compression and shear loading was discussed.Bottom girders with 2 different kinds of cutout were analyzed and compared with by finite element method from the strength and buckling aspects.The analytical results can be used as the reference in practical ship structural design.",
        "keywords": [
            "cut-out",
            "girder",
            "load bearing capacity",
            "strength",
            "buckle"
        ],
        "authors": [
            {
                "name": "WANG Xun",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            }
        ],
        "venue": "Ship & Ocean Engineering",
        "year": 2010
    },
    "W1B1R9TA": {
        "id": "W1B1R9TA",
        "title": "Calculation and research on ultimate strength of panels and stiffened-plates under combined loads",
        "abstract": "This paper mainly do the calculation and research on the ultimate strength of panels and stiffened-plates under combined bi-axial compressions and lateral pressure based on nonlinear FEM. It focused on the applying of the initial imperfection of the plate and stiffened-plate, and also on discussing the element size, boundary condition, multi-load step for nonlinear FEM solution. The paper has carried out the ultimate strength calculation for a panel and a stiffened-plate under various combined bi-axial compression and lateral pressure. It is showed that the procedures taken in this paper is correct and effective, and the results are agreed well with other references.",
        "keywords": [
            "Initial deformation",
            "Panel",
            "Stiffened plate",
            "Ultimate strength"
        ],
        "authors": [
            {
                "name": "Huwei Cui",
                "org": "Wuhan University of Technology(Wuhan University of Technology),Wuhan,China"
            },
            {
                "name": "Ping Yang",
                "org": "Wuhan University of Technology(Wuhan University of Technology),Wuhan,China"
            }
        ],
        "venue": "Wuhan Ligong Daxue Xuebao (Jiaotong Kexue Yu Gongcheng Ban)/Journal of Wuhan University of Technology (Transportation Science and Engineering)",
        "year": 2012
    },
    "gDctD8eO": {
        "id": "gDctD8eO",
        "title": "Analysis and Assessment of Residual Ultimate Strength for Damaged Oil Tankers by Progressive Method",
        "abstract": "Based on the Common Structural Rules for oil tankers of IACS,a program was developed to calculate both the ultimate strength of intact ship and residual ultimate strength of damaged ship by progressive method.Considering the asymmetry cross section of damaged hull girder and the different inclination conditions after grounding and collision,a double-shell oil tanker had been investigated for accidental situations and the results of residual ultimate strength were presented.",
        "keywords": [
            "residual ultimate strength",
            "damaged oil tankers",
            "progressive method"
        ],
        "authors": [
            {
                "name": "ZHENG Lan",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            }
        ],
        "venue": "Ship & Ocean Engineering",
        "year": 2008
    },
    "W773obC6": {
        "id": "W773obC6",
        "title": "Dynamic Response of Stiffened Plates under In-Plane Fluid-Solid Impact Loading",
        "abstract": "When ships are sailing in rough seas, the structures of ships are subjected to severe slamming induced by waves. These impact loads will make hull structures buckle, and then inactivate the whole load carrying capacity of marine structures and brings in a catastrophic end. It is vitally important to study on the dynamic behavior of stiffened plates, which is one of the fundamental structural components of ship structures. On the basis of discrete stiffened plates model, the dynamic response of imperfect rectangular stiffened plates with elastically restrained edges under in-plane fluid-solid impact loading is investigated theoretically in this paper. The spline function is chosen to describe the deflection. The governing equations of the dynamic response of imperfect stiffened plates are obtained by weighted residual method. The equations are solved by a fourth-order Runge-Kutta method, and the homologous computer code is developed in FORTRAN. The formed B-spline function is adaptable to any elastic restraints against rotation. The influence of initial geometric imperfection, load duration, stiffeners and elastic restraints are discussed. The results indicate that they are important factors affecting stiffened plates' dynamic behavior. The load carrying capacity of stiffened plates will be enhanced if the elastic restraints are increased properly or the initial geometric imperfection and load duration are decreased.",
        "keywords": [
            "weighted residual method",
            "fluid-solid impact loading",
            "elastic restraint",
            "spline function",
            "stiffened plate",
            "dynamic response"
        ],
        "authors": [
            {
                "name": "Peng Ying",
                "org": "School of Transportation, Wuhan University of Technology, Wuhan , China"
            },
            {
                "name": "Yang Ping",
                "org": "School of Transportation, Wuhan University of Technology, Wuhan , China"
            }
        ],
        "venue": "Chinese Journal of Ship Research",
        "year": 2006
    },
    "8L3YKgwa": {
        "id": "8L3YKgwa",
        "title": "Ultimate Strength Analysis for Inland Double-Hull Ships",
        "abstract": "The stress distribution for the inland double-hull ships in the ultimate limit state was assumed to derive the formulas for calculating the ultimate strength of double-hull ships based on direct calculation method.A calculation of the structural ultimate capacity for an actual inland ship was carried out for the intact and damaged conditions.The results were compared with the ones from the progressive collapse method.It showed than the stress distribution assumed in this paper is reasonable,and can be used in practical calculation.",
        "keywords": [
            "ultimate strength",
            "damaged hull",
            "double-hull ship"
        ],
        "authors": [
            {
                "name": "DENG Lin-feng",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            }
        ],
        "venue": "Ship & Ocean Engineering",
        "year": 2008
    },
    "pjx5mWqw": {
        "id": "pjx5mWqw",
        "title": "Numerical Analysis on the Ultimate Strength of Corrugated Bulkheads",
        "abstract": "The paper carries out FEM analyses on the ultimate strength of corrugated bulkheads under linear hydrostatic pressure by means of ANSYS software,taking into account of geometry non-linearity and material non-linearity.Many influence factors will affect the ultimate strength of corrugated bulkheads,including corrugate angle,plate thickness,boundary condition and steel consumption,a discussion of different variables of the above influence is given.By the computational analyses,it shows that increasing either corrugate angle or plate thickness has effect on ultimate strength of corrugated bulkheads and unit consumption of steel,but the former is proved to be more effective on the increase of ultimate strength,and bulkhead condition affects largely on ultimate bearing capacity,and it also shows that the reasonable boundary condition can significantly improve structure bearing capacity.",
        "keywords": [
            "ultimate strength",
            "corrugated bulkheads",
            "numerical calculation"
        ],
        "authors": [
            {
                "name": "Huang Lei",
                "org": " School of Transportation,Wuhan University of Technology,Wuhan ,China"
            },
            {
                "name": "Yang Ping",
                "org": " School of Transportation,Wuhan University of Technology,Wuhan ,China"
            }
        ],
        "venue": "Chinese Journal of Ship Research",
        "year": 2011
    },
    "AcoSqfVZ": {
        "id": "AcoSqfVZ",
        "title": "Force Analysis and Non-linear FEM Calculation for Flexible Mattress",
        "abstract": "Based on the theoretical analysis for flexible mattress during sinking in hydrostatic water,non-linear FEM were used to analyze the tension force and its distribution on flexible mattress.The results from non-linear FEA reveal that the tension forces subjected by flexible mattress are in the condition of uneven distribution,which has to be paid attention in the mattress design and the practical engineering project application.",
        "keywords": [
            "non linear FEM",
            "flexible mattress",
            "force analysis"
        ],
        "authors": [
            {
                "name": "LIU Ying",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            }
        ],
        "venue": "Ship & Ocean Engineering",
        "year": 2011
    },
    "2MkmdFUp": {
        "id": "2MkmdFUp",
        "title": "Research on Ultimate Strength of Ship Girders with Cutout",
        "abstract": "Nonlinear FEM was performed for the ultimate strength analysis for series ship girders with cutout subjected to longitudinal compression.Base on the numerical results,a prediction formula for the ultimate strength assessment of ship girders was presented.Comparisons between nonlinear FEM results and the ones of the proposed formula showed that the proposed prediction formula is reasonable with high accuracy.",
        "keywords": [
            "ultimate strength",
            "finite element analysis",
            "ship girders with cutout"
        ],
        "authors": [
            {
                "name": "DING Yan-wei",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            }
        ],
        "venue": "Ship & Ocean Engineering",
        "year": 2011
    },
    "6QOBwO6K": {
        "id": "6QOBwO6K",
        "title": "Procedure Design of the Progressive-Collapse-Method in Strength Assessment for Inland Vessels",
        "abstract": "During the modern structural design process and the subsequent strength assessment of ships,the conventional linear elastic theory is no longer appropriate in estimating the maximum working loads.In stead,the progressive collapse method has been widely used for its high computational efficiency and reli ability.This method,also known as the Smith Method or the incremental iterative method,is established based on the average stress-strain relationship of stiffened plate units.However,the application of the Smith Method on inland vessels has been hardly investigated.This paper employs the FEM to execute a se ries of calculations of stiffened plate elements,incorporating the material nonlinearity and the initial defor mation of structures due to welding.The slenderness ratio of plates and stiffeners is chosen to be the main variable,and the Istopt software is used to fit each curve with the average stress-strain relationship for in land vessels so that a function database can be established.Also,this paper describes the detailed calcula tion procedure of the progressive collapse method and discusses the particular technique of variable interpo lation.",
        "keywords": [
            "hull girder",
            "ultimate strength",
            "progressive collapse method",
            "inland vessels"
        ],
        "authors": [
            {
                "name": "LUO Wengang",
                "org": " China Shipbuilding Industry Corporation Architecture Design Research Insitute Co.,Ltd,Beijing ,China"
            },
            {
                "name": "YANG Ping",
                "org": " School of Transportation,Wuhan University of Technology,Wuhan ,China"
            },
            {
                "name": "CUI Huwei",
                "org": " School of Transportation,Wuhan University of Technology,Wuhan ,China"
            },
            {
                "name": "BAI Xiaoxi",
                "org": " Dalian Branch of China Classification Society,Dalian ,China"
            }
        ],
        "venue": "Chinese Journal of Ship Research",
        "year": 2013
    },
    "tZX05s6W": {
        "id": "tZX05s6W",
        "title": "Estimation of Ultimate Strength for Damaged Ships",
        "abstract": "Using the combination of full-plastic-buckling stress distribution pattern and elastic-plastic stress distribution pattern,the paper derives formulas to calculate the ultimate strength of moment for damaged ships.Through an actual damaged ship example,the calculated results from the two methods are compared with each other to estimate the structural ultimate capacity.It shows that the results are quite well and can be used in practice.",
        "keywords": [
            "elastic-plastic analysis",
            "buckling",
            "ultimate moment strength",
            "plastic analysis",
            "damaged ship"
        ],
        "authors": [
            {
                "name": "Dai Lu-ping",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            },
            {
                "name": "Yang Ping",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            }
        ],
        "venue": "Chinese Journal of Ship Research",
        "year": 2008
    },
    "WOgsm1Nb": {
        "id": "WOgsm1Nb",
        "title": "Analysis and Assessment of Residual Ultimate Strength for Damaged Bulk Carriers",
        "abstract": "Considering the asymmetry cross section of damaged hull girder and the different inclination conditions after grounding and collision,based on the Common Structural Rules for bulk carriers by IACS,this paper proposes the progressive collapse method to analyze the residual ultimate strength when the damaged ship is on several accidental situations.A program is developed in FORTRAN language and can be used to calculate the residual ultimate strength for damaged ships.A bulk carrier is systematically assessed for its safety and some useful conclusions have been drawn.",
        "keywords": [
            "residual ultimate strength",
            "grounding and collision",
            "damaged ship",
            "common structural rules"
        ],
        "authors": [
            {
                "name": "Huang Ying-chun",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            },
            {
                "name": "Yang Ping",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            }
        ],
        "venue": "Chinese Journal of Ship Research",
        "year": 2008
    },
    "P0rq1Uuc": {
        "id": "P0rq1Uuc",
        "title": "Tripping calculation and analysis for stiffeners under axial compression",
        "abstract": "According to different calculation methods for comparative analysis and discussion to the results of buckling stress of tripping for stiffeners,the paper gets a practical alternative formula based on the formula of Bleich.The comparison with the results from finite element method shows that the formula is correct,and simple in form and convenient for design and calculation in practical application.It can be used to calculate the tripping stress of the actual stiffeners under axial compression.",
        "keywords": [
            "buckling",
            "FEM",
            "tripping",
            "stiffeners"
        ],
        "authors": [
            {
                "name": "LIN Jie",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            }
        ],
        "venue": "Ship & Ocean Engineering",
        "year": 2007
    },
    "8G8LLMRe": {
        "id": "8G8LLMRe",
        "title": "Analysis of the Load Bearing Capacity of Ship Structural Details",
        "abstract": "By the finite element program ANSYS,the load bearing capacity of the beam structural details of ship was discussed when the bracket's size changes.And three connection patterns of bottom girder were analyzed from the strength and buckling aspects.",
        "keywords": [
            "load bearing capacity",
            "buckling",
            "strength",
            "ship structural details",
            "bracket"
        ],
        "authors": [
            {
                "name": "WANG Bo",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            }
        ],
        "venue": "Ship & Ocean Engineering",
        "year": 2010
    },
    "4N25r7lo": {
        "id": "4N25r7lo",
        "title": "Advances in Studies on Dynamic Buckling of Structures",
        "abstract": "The advances on dynamic buckling of structures are reviewed systematically in this paper.The dynamic buckling problems of plates and stiffened plates subjected to dynamic loading are emphatically described,and the commonly used dynamic buckling criteria are introduced.To impact buckling of structures made of composite materials,it is suggested that more detail study are needed in the field.The dynamic ultimate strength of plate structures under implane dynamic loading is very important in engineering practice.",
        "keywords": [
            "structure",
            "dynamic loading",
            "dy namic buckling criteria",
            "dynamic buckling",
            "suicide prevention",
            "injury prevention",
            "ergonomics",
            "human factors",
            "occupational safety"
        ],
        "authors": [
            {
                "name": "Peng Ying",
                "org": "School of Transportation,WUT,Wuhan "
            },
            {
                "name": "Yang Ping",
                "org": "School of Transportation,WUT,Wuhan "
            }
        ],
        "venue": "Journal of Wuhan University of Technology(Transportation Science & Engineering)",
        "year": 2007
    },
    "kJS3s5lS": {
        "id": "kJS3s5lS",
        "title": "Buckling analysis for the multi-stiffened plates",
        "abstract": "Based on the characteristics of the multi-stiffened plates,the buckling strength theory of continuous column with internal elastic supports under axial compression was used to derive the practical calculation formula for the critical load of wholly buckling.The validity of the formula was analyzed by comparing the theoretical results with numerical ones from FEM,which showed that the presented formula is simple for practical use with quite good results.",
        "keywords": [
            "multi-stiffened plate structure stability"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "School of Transportation Wuhan University of technology Wuhan "
            },
            {
                "name": "LIU Yan-feng",
                "org": "School of Transportation Wuhan University of technology Wuhan "
            }
        ],
        "venue": "Ship & Ocean Engineering",
        "year": 2006
    },
    "95dAyl1f": {
        "id": "95dAyl1f",
        "title": "Assessment of residual ultimate strength of damaged ship hulls",
        "abstract": "The high frequency of navigation accidents sets off a new upsurge of research on damaged ship hulls' residual strength. This paper took a rapid and effective assessment to the residual strength of a damaged container ship after collision and grounding respectively based on the index of residual strength and ultimate loads. The loads are calculated according to the CSR-JBP while residual strength according to non-linear FEM which shows a good result comparing to analytical method. This method is based on design, having directive significance to engineering design and marine rescue in a great degree.",
        "keywords": [
            "Collision",
            "Grounding",
            "Non-linear FEM",
            "Residual strength"
        ],
        "authors": [
            {
                "name": "Benguo Gao",
                "org": "Kunming Shipborne Equipment Research and Test Center(Kunming Shipborne Equipment Research and Test Centre,Kunming Shipborne Equipment Research and Test Center),Kunming,China"
            },
            {
                "name": "Ping Yang",
                "org": "Wuhan University of Technology(Wuhan University of Technology),Wuhan,China"
            }
        ],
        "venue": "Wuhan Ligong Daxue Xuebao (Jiaotong Kexue Yu Gongcheng Ban)/Journal of Wuhan University of Technology (Transportation Science and Engineering)",
        "year": 2013
    },
    "xQEhDnu1": {
        "id": "xQEhDnu1",
        "title": "Optimum Design of Mechanical Properties of Aluminum Sheets-with-ribs of High Speed Ships",
        "abstract": "The sheet-with-ribs under different levels of lateral loads were optimized by theoretical method to get the preliminary scantlings of the sections.Buckling behavior of local plate and overall panel of the sheets-with-ribs under the uniaxially compressed loads were calculated by FEM to optimize the scantlings further.Numerical results of nonlinear FEA showed that the stress level of designed sheets-with-ribs with different scantlings is nearly same.The ultimate bearing capacities of the sheets-with-ribs can be calculated.",
        "keywords": [
            "aluminum alloy",
            "buckling",
            "strength",
            "structural design",
            "sheet-with-ribs"
        ],
        "authors": [
            {
                "name": "SHI Li-juan",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            }
        ],
        "venue": "Ship & Ocean Engineering",
        "year": 2011
    },
    "Gd9BdXK5": {
        "id": "Gd9BdXK5",
        "title": "Nonlinear dynamic response and sensitivity analysis of stiffened plates under fluid-solid impact loading",
        "abstract": "Considering large deformation and neglecting damping effect, the nonlinear transient response of stiffened plates under fluid solid impact loading is analyzed in this paper based on the FEM software ANSYS. To examine the influence of different loading functions on the dynamic behavior of stiffened plates, in addition to the fluid-solid impact, the rectangular and triangular pulses are investigated. The influences of load amplitude, load duration, plate thickness, the ratio of stiffeners' volume to plate's and the stiffener's width to height ratio are discussed respectively, and the sensitivities of them are calculated.",
        "keywords": [
            "Fluid solid impact loading",
            "Large deformation",
            "Nonlinear transient response",
            "Sensitivities",
            "Stiffened plate"
        ],
        "authors": [
            {
                "name": "Yinghong Peng",
                "org": "Wuhan University of Technology(Wuhan University of Technology),Wuhan,China"
            },
            {
                "name": "Ping Yang",
                "org": "Wuhan University of Technology(Wuhan University of Technology),Wuhan,China"
            }
        ],
        "venue": "Wuhan Ligong Daxue Xuebao (Jiaotong Kexue Yu Gongcheng Ban)/Journal of Wuhan University of Technology (Transportation Science and Engineering)",
        "year": 2007
    },
    "7foDXoTA": {
        "id": "7foDXoTA",
        "title": "Derivation and Modification of the Strength Formula for Two-way Multi-stiffened Plates",
        "abstract": "The two-way multi-stiffened plate was simplifies by an orthotropic plate model.By deriving the equilibrium equation in dimensionless form and using the bending results of isotropic plate,the maximum stress was determined for the two-way multi-stiffened plates.Detailed analysis of the strength was carried out to five patterns of stiffened plates in two styles and different dimensions.The numerical results showed that the presented formula could forecast the stress of the plate accurately.",
        "keywords": [
            "strength formula",
            "two-way multi-stiffened plate",
            "orthotropic plate"
        ],
        "authors": [
            {
                "name": "TANG Gang",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            }
        ],
        "venue": "Ship & Ocean Engineering",
        "year": 2012
    },
    "z4LXRnPb": {
        "id": "z4LXRnPb",
        "title": "Analysis on the Ultimate Strength and Sensitivity of Bulk Carriers Based on IACS Common Rules",
        "abstract": "We analyzed the ultimate strength of a bulk carrier using the incremental-iterative approach based on the Common Structural Rules for Bulk Carrier by IACS. Hence a program in FORTRAN language was developed to calculate the ultimate strength of the box structure and the bulk carrier. The sensitivity of several parameters to the ultimate hull bending moment of the bulk carrier was discussed. The ultimate strength of hull is dependent largely on the yield stress and the plate thickness. The calculation results obtained by the program were also compared with the results of related literature reported in the International Ship and Offshore Structures Congress. The comparison indicated that the program developed is reliable and has a good accuracy.",
        "keywords": [
            "ultimate strength",
            "sensitivity",
            "bulk carrier",
            "common structural rules"
        ],
        "authors": [
            {
                "name": "Wang Zhu",
                "org": "School of Transportation, Wuhan Univ. of Tech.,Wuhan ,China"
            },
            {
                "name": "Yang Ping",
                "org": "School of Transportation, Wuhan Univ. of Tech.,Wuhan ,China"
            }
        ],
        "venue": "Chinese Journal of Ship Research",
        "year": 2007
    },
    "Nu0NIPOw": {
        "id": "Nu0NIPOw",
        "title": "Application of the Patran\u2032s PCL Language for the Ultimate Strength of Panel and Stiffened Plate",
        "abstract": "The Patran's.ses file was generated by a Fortran program to add the specified initial deflection to the FEM models of panel and stiffened plate.Detailed analyses of the ultimate strength have been carried out to six panels and four stiffened plates.The results showed that the presented method can simulate any complicated deformation of the stiffened plate so as to get a more accurate assessment of the ultimate strength.",
        "keywords": [
            "ultimate strength",
            "PCL",
            "NON-FEM"
        ],
        "authors": [
            {
                "name": "LUO Gang",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            }
        ],
        "venue": "Ship & Ocean Engineering",
        "year": 2011
    },
    "TxioEsLl": {
        "id": "TxioEsLl",
        "title": "Dynamic buckling of imperfect rectangular plates under in-plane fluid-structure impact loading",
        "abstract": "The spline function is chosen to describe the deflection.The governing equations of the dynamic buckling of imperfect rectangular plates are obtained by weighted residual method.The equations are solved by a fourth-order Runge-Kutta method,and the computational code is developed in FORTRAN.The formed B- spline function is adaptable to any elastic restraints against rotation.The influences of initial geometric imper- fection,load duration and elastic restraints are discussed.",
        "keywords": [
            "spline function weighted residual method",
            "fluid-structure impact loading",
            "elastic restraints",
            "dynamic buckling"
        ],
        "authors": [
            {
                "name": "PENG Ying",
                "org": " School of Transportation Wuhan University of Technology Wuhan "
            },
            {
                "name": "YANG Ping",
                "org": " School of Transportation Wuhan University of Technology Wuhan "
            }
        ],
        "venue": "Ship & Ocean Engineering",
        "year": 2007
    },
    "Hii7I5as": {
        "id": "Hii7I5as",
        "title": "Analysis and assessment of residual ultimate strength for damaged ships",
        "abstract": "The aim of this study is to analyze and assess the residual ultimate strength of damaged ships, considering the asymmetry of damaged hull girder cross section and also the different inclination conditions after grounding and collision. It is the first time to apply the progressive method for this kind of study. The advantages are that it needn't use assumed stress distribution as such in applying the direct method. Several ship types have been investigated for accidental situations and the results of a bulk carrier are presented as an example. The method developed in this paper should be useful for ship preliminary structural design.",
        "keywords": [
            "Damaged ships",
            "Grounding and collision",
            "Residual ultimate strength"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "Wuhan University of Technology(Wuhan University of Technology),Wuhan,China"
            },
            {
                "name": "Junmei Liu",
                "org": "Wuhan University of Technology(Wuhan University of Technology),Wuhan,China"
            }
        ],
        "venue": "Wuhan Ligong Daxue Xuebao (Jiaotong Kexue Yu Gongcheng Ban)/Journal of Wuhan University of Technology (Transportation Science and Engineering)",
        "year": 2006
    },
    "QSE8G59e": {
        "id": "QSE8G59e",
        "title": "Ultimate Strength of Stiffened Plate Under Axial Compression",
        "abstract": "Ultimate strength analyses have been performed by Non linear FEM to a series of stiffened plates subjected to longitudinal compression.The numerical results from non-linear FEM are validated with Smith and Tanaka experiments.A proposed formula is presented for the ultimate strength prediction of stiffened plates.The formula is in good agreement with a large number of FEM calculations and experiment results.",
        "keywords": [
            "ultimate strength",
            "FEM",
            "stiffened plate"
        ],
        "authors": [
            {
                "name": "Zhang Xiaodan",
                "org": "College of Transportation,Wuhan University of Technology,Wuhan ,China"
            },
            {
                "name": "Yang Ping",
                "org": "College of Transportation,Wuhan University of Technology,Wuhan ,China"
            }
        ],
        "venue": "Journal of Wuhan University of Technology(Transportation Science & Engineering)",
        "year": 2011
    },
    "Ro7gSNOc": {
        "id": "Ro7gSNOc",
        "title": "Prediction on Ultimate Strength of the Two-Way Orthogonal Multi-Stiffened Plates",
        "abstract": "Nonlinear FEM has been performed to a series of two-way orthogonal multi-stiffened plates sub jected to axial compression load.Based on numerical results and orthotropic plate theory,we introduced three parameters,which were longitudinal column slenderness ratio \u03bbx,transverse column slenderness ra tio \u03bby,and plate slenderness ratio \u03b2,to form a prediction formula to calculate the ultimate strength of two-way orthogonal multi-stiffened plates.Then the ultimate strength for three types of multi-stiffened plates was analyzed.The results show that the calculation data agree well with the results of finite element analysis,and the proposed prediction formula is able to accurately predict the ultimate of two-way orthogo nal multi-stiffened plates.",
        "keywords": [
            "ultimate strength formula",
            "nonlinear FEM analysis",
            "two-way orthogonal multi-stiffened plates"
        ],
        "authors": [
            {
                "name": "QIU Ji-dong",
                "org": " School of Transportation,Wuhan University of Technology,Wuhan ,China"
            },
            {
                "name": "YANG Ping",
                "org": " School of Transportation,Wuhan University of Technology,Wuhan ,China"
            }
        ],
        "venue": "Chinese Journal of Ship Research",
        "year": 2012
    },
    "aajlyiGu": {
        "id": "aajlyiGu",
        "title": "Lateral Buckling of T-Stiffeners under Lateral Loading",
        "abstract": "In the case of ship collapse of hull girder in flooded condition,the bulkheads are usually the vital structures.The critical load formula of elastic buckling of bulkhead stiffeners under the lateral hydrostatic pressure is derived by the energy method.The comparison with the results of FEM proves that the formula is correct,simple and practical.",
        "keywords": [
            "energy method",
            "critical load",
            "FEM",
            "stiffeners"
        ],
        "authors": [
            {
                "name": "XUAN Dong-liang",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            }
        ],
        "venue": "Ship & Ocean Engineering",
        "year": 2008
    },
    "wWic89CR": {
        "id": "wWic89CR",
        "title": "Analysis of ultimate strength and sensitivity for oil tankers based on IACS common rules",
        "abstract": "A program was developed in FORTRAN language by using the incremental-iterative approach to calculate the longitudinal ultimate strength of the box girder and oil tanker based on the common structural rules for oil tankers(JTP).In comparison with the results from some famous experts of International Ship & Offshore Structures Congress,it can be seen that the simplified method has engineering accuracy and can be used in the pre-phase of design.Finally,this paper carries out the sensitivity discussion about several parameters which affecting the ultimate moment of oil tankers.",
        "keywords": [
            "ultimate strength",
            "sensitivity",
            "curves of stress-strain",
            "oil tanker",
            "common structural rules"
        ],
        "authors": [
            {
                "name": "MEI Yi-rong",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Transportation,Wuhan University of Technology,Wuhan ,China"
            }
        ],
        "venue": "Ship & Ocean Engineering",
        "year": 2007
    },
    "Qvh7Yq0E": {
        "id": "Qvh7Yq0E",
        "title": "Reduced defect density in microcrystalline silicon by hydrogen plasma treatment",
        "abstract": "The effect of hydrogen plasma treatment(HPT) during the initial stage of microcrystalline silicon(\u03bcc-Si) growth on the defect density of \u03bcc-Si has been investigated. Lower absorption coefficient in the 0.8\u20131.0 eV indicated less defect density compared to its counterpart without HPT. The infrared spectroscopy of \u03bcc-Si with HPT shows an increase in 2040 cm-1, which reveals more Si\u2013H in the amorphous/crystalline interfaces. We ascribe the decrease of defect density to hydrogen passivation of the dangling bonds. Improved performance of \u03bcc-Si solar cell with HPT is due to the reduced defect density.",
        "keywords": [
            "defect density",
            "hydrogen plasma treatment",
            "microcrystalline silicon",
            "passivation"
        ],
        "authors": [
            {
                "name": "Li Jingyan",
                "org": ""
            },
            {
                "name": "Xiangbo Zeng",
                "org": "Institute of Semiconductors Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "Li Hao",
                "org": ""
            },
            {
                "name": "Xiaobing Xie",
                "org": "Institute of Semiconductors Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "Yang Ping",
                "org": ""
            },
            {
                "name": "Haibo Xiao",
                "org": "Institute of Semiconductors Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "Zhang Xiaodong",
                "org": ""
            },
            {
                "name": "Wang Qiming",
                "org": ""
            }
        ],
        "venue": "\u534a\u5bfc\u4f53\u5b66\u62a5(\u82f1\u6587\u7248)",
        "year": 2013
    },
    "aQsGyD64": {
        "id": "aQsGyD64",
        "title": "Goal conflict resolution of multi-agent systems based on distributed negotiation evolution algorithm",
        "abstract": "In order to deal with goal conflict resolution in the research of multi-agent systems, a multi-objective optimization model is presented to search for some compromise among coordinate local goals of multi-agent and collective goals of systems. Under the distributed planning frame of multi-agent, a distributed negotiation evolution algorithm based on the genetic algorithm (DNEAGA) which is used for solving multi-objective programming model is proposed. In order to keep the solutions diversity and increase the convergence speed, a selection operator in genetic algorithm is designed. Simulation experiments show that the new selection operator can improve the solutions quality effectively. Finally, the DNEAGA is applied to solving the goal conflict in maneuver route planning of operations, and the effectiveness of the proposed algorithm is verified.",
        "keywords": [
            "Distributed negotiation evolution algorithm",
            "Genetic algorithm",
            "Goal conflict resolution",
            "Multi-agent system",
            "Multiobjective optimization",
            "Pareto optimal solution"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "Second Artillery Engineering College Xi An(Second Artillery Engineering College,The Second Artillery Engineering College,The Second Artillery Engineering Institute,Second Artillery Engineering Institute),Xi An,China"
            },
            {
                "name": "LIU Wei-dong",
                "org": "Second Artillery Engineering College Xi An(Second Artillery Engineering College,The Second Artillery Engineering College,The Second Artillery Engineering Institute,Second Artillery Engineering Institute),Xi An,China"
            },
            {
                "name": "BI Yi-ming",
                "org": "Second Artillery Engineering College Xi An(Second Artillery Engineering College,The Second Artillery Engineering College,The Second Artillery Engineering Institute,Second Artillery Engineering Institute),Xi An,China"
            }
        ],
        "venue": "Xi Tong Gong Cheng Yu Dian Zi Ji Shu/Systems Engineering and Electronics",
        "year": 2009
    },
    "PdRhWz6d": {
        "id": "PdRhWz6d",
        "title": "Research on Comprehensive Evaluation Models and Methods of Operational Effectiveness of Conventional Warhead",
        "abstract": "Overall models and evaluation methods are researched on combat effectiveness of conventional warhead.The index system of the effectiveness is presented systemicically,a group of models used to support the research on combat effectiveness of are given.These models have features of multiresolution,more operational factors are taken into account in the index system and evaluation models than before.Corresponding evaluation method in different hierarchy is given aiming at hierarchical structures of effectiveness evaluation and models.",
        "keywords": [
            "conventional warhead",
            "evaluation method",
            "index system",
            "total combat effectiveness",
            "evaluation model"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "The Second Artillery Engineering Collage,Xi'an ,China"
            },
            {
                "name": "BI Yi-ming",
                "org": "The Second Artillery Engineering Collage,Xi'an ,China"
            }
        ],
        "venue": "Fire Control and Command Control",
        "year": 2007
    },
    "yI9O3oOS": {
        "id": "yI9O3oOS",
        "title": "Model and Simulation of Ballistic Missile Penetrate ABL",
        "abstract": "The infrared characteristics of the the ballistic missiles is very obvious in active phase,it is easy to be detected by infrared satellite of space-based orbit.ABL laser for ballistic missile boost phase missile interception means to intercept.This article makes the ballistic missiles's active penetration of ABL modeling,and take simulation analysis by the battlefield environment in the process of penetration.",
        "keywords": [
            "penetration",
            "ABL",
            "ballistic missile"
        ],
        "authors": [
            {
                "name": "PEI Ying",
                "org": "The Second Artillery Engineering University,Xi'an "
            },
            {
                "name": "YANG Ping",
                "org": "The Second Artillery Engineering University,Xi'an "
            },
            {
                "name": "ZENG Jing",
                "org": "The Second Artillery Engineering University,Xi'an "
            },
            {
                "name": "TIAN Zhi",
                "org": "The Second Artillery Engineering University,Xi'an "
            }
        ],
        "venue": "Ship Electronic Engineering",
        "year": 2013
    },
    "9QYr77Dz": {
        "id": "9QYr77Dz",
        "title": "Combat Mission Plan Scenario Modeling and Visual Simulation",
        "abstract": "Modeling simulation scenario is an important component in military simulation development process.How to transform combat mission plan expression from natural language into visual simulation is an issue to be solved urgently in military process simulation.The basic thought of scenario concept modeling and visual simulation are given out while the CMMA method is referenced and the Object-Oriented software development thinking is applied.The thought includes: the formulated expression of scenario;the CMMA of scenario;the mapping from concept model to information model;the standardized description framework of scenario document;the simulation scenario database construction;the class encapsulation and visualization of scenario.The proposed thought is instantiated by a weapon combat background.In the end,the feasibility of the proposed thought is affirmed and some practical experiences are summarized.",
        "keywords": [
            "Scenario",
            "Virtual reality(VR)",
            "Extensible markup language(XML)",
            "Unified modeling language(UML)",
            "Combat simulation"
        ],
        "authors": [
            {
                "name": "LIU Liang",
                "org": "The Second Artillery Engineering Institute,Xi'an Shanxi ,China"
            },
            {
                "name": "BI Yi-ming",
                "org": "The Second Artillery Engineering Institute,Xi'an Shanxi ,China"
            },
            {
                "name": "YANG Ping",
                "org": "The Second Artillery Engineering Institute,Xi'an Shanxi ,China"
            }
        ],
        "venue": "Computer Simulation",
        "year": 2009
    },
    "EjBcnFBI": {
        "id": "EjBcnFBI",
        "title": "Research on Model and Algorithm of Missile Operational Mission Planning under Complex Constraints",
        "abstract": "Missile operational mission planning is a complex problem relate to time, resource, quality and other constraints. Basic constraint satisfaction model is extended through defining constraint satisfaction utility at first. A constraint satisfaction optimize model about missile operational mission planning is made. On the basis, algorithms of time promulgate and utility promulgate are studied. A optimize resolving frame is presented based on integration utility. The model and algorithm frame not only are easy to solve complex problems that have manifold constraints, but also have preferable general performance. Through defining soft and hard constraints, mission planning in practice will have further flexible.",
        "keywords": [
            "missile operational mission planning",
            "constraint satisfaction optimize model",
            "time promulgate algorithm",
            "constraint satisfaction utility",
            "utility promulgate algorithm"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "The Second Artillery Engineering College, Xi\u2019an , China"
            },
            {
                "name": "BI Yi-ming",
                "org": "The Second Artillery Engineering College, Xi\u2019an , China"
            },
            {
                "name": "XIAO Hai-bo",
                "org": "The Second Artillery Engineering College, Xi\u2019an , China"
            },
            {
                "name": "GU Li-lin",
                "org": "The Second Artillery Engineering College, Xi\u2019an , China"
            }
        ],
        "venue": "Command Control & Simulation",
        "year": 2009
    },
    "WK3WjYCh": {
        "id": "WK3WjYCh",
        "title": "Research on Agent Resource Conflict Resolution Algorithm Based on Negotiation Theory",
        "abstract": "Aimmg to Agent resource conflict problem in distributed planning system,the classification of resource conflict is studied.A resource conflict resolution algorithm about the exclusive resource that able to be utilized repeatedly is presented from the idea of optimal resource allocation based on Agent negotiation theory.The paper proves the negotiation strategy's optimization of the algorithm.The algorithm have settled preferably this conflict problem.The example shows the algorithm is effective.",
        "keywords": [
            "Agent",
            "negotiation",
            "resource conflict",
            "distributed planning",
            "resolution algorithm"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "The Second Artillery Engineering College,Shanxi,,China"
            },
            {
                "name": "LONG Zheng-ping",
                "org": "The Second Artillery Engineering College,Shanxi,,China"
            },
            {
                "name": "WANG Tong",
                "org": "The Second Artillery Engineering College,Shanxi,,China"
            }
        ],
        "venue": "Command Control & Simulation",
        "year": 2011
    },
    "xBfOqtej": {
        "id": "xBfOqtej",
        "title": "Application of the Simulation Technique in the Batch Testing Optimize of Conventional Missiles",
        "abstract": "Testing the amount of quantity qualified conventional missiles in a short time is a kind of important battle style in the future battle.The paper imitates the working procedure progress of the missile batch testing in discrete simulation method,by means of the simulation result.It can be obviously observed that key working procedures affect the time of the batching testing,and then the batch testing time can be greatly reduced for further by adding some sites and optimizing its procedure that provided the method with the experiment,also for future developments of the technique battlefield provides consult opinion.",
        "keywords": [
            "conventional missile",
            "discrete affair",
            "simulation",
            "batch testing"
        ],
        "authors": [
            {
                "name": "LI Mingyu",
                "org": "Postgraduate Company One,the Second Artillery Engineering College,Xi~\u2032an Shaanxi ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Postgraduate Company One,the Second Artillery Engineering College,Xi~\u2032an Shaanxi ,China"
            },
            {
                "name": "BI Yiming",
                "org": "Postgraduate Company One,the Second Artillery Engineering College,Xi~\u2032an Shaanxi ,China"
            }
        ],
        "venue": "Journal of the Academy of Equipment Command & Technology",
        "year": 2006
    },
    "EDoC3XO7": {
        "id": "EDoC3XO7",
        "title": "Maneuver routing selection based on ant colony algorithm and tabu search method",
        "abstract": "To meet the new requirements for maneuver routing selection under the new situation,the maneuvering time limitation and maneuvering decentralization both are simultaneously requested to come up.The mathematical model of the question is built,and the information entropy theory is quoted as the assessment rule.The heuristic method combining the improved ant colony algorithm with the tabu search algorithm is applied to solve the question,and the specific processing steps are also given.By the analysis of the simulation results,the algorithm is proved to be effective.",
        "keywords": [
            "tabu search",
            "maneuver routing selection",
            "ant colony algorithm",
            "information entropy"
        ],
        "authors": [
            {
                "name": "LIU Wei-dong",
                "org": "The Second Artillery Engineering Coll.,Xi'an ,China"
            },
            {
                "name": "LIU Shun-cheng",
                "org": "The Second Artillery Engineering Coll.,Xi'an ,China"
            },
            {
                "name": "YANG Ping",
                "org": "The Second Artillery Engineering Coll.,Xi'an ,China"
            },
            {
                "name": "JIA Kai",
                "org": "The Second Artillery Engineering Coll.,Xi'an ,China"
            }
        ],
        "venue": "Systems Engineering and Electronics",
        "year": 2008
    },
    "obJ9CFGx": {
        "id": "obJ9CFGx",
        "title": "Agent Dynamic Task Allocation Based on Improved Contract Net Protocol",
        "abstract": "Aimed to dynamic task allocation problem in missile planning system,the formalization description and mathematic model about task allocation are studied.The characteristic of dynamic task allocation is analyzed.An improved contract net algorithm about Agent dynamic task allocation problem is proposed.The algorithm settles the dynamic task allocation problem in uncertain opening environment.The example shows the algorithm is effective.",
        "keywords": [
            "model",
            "multi-Agent systems",
            "task allocation",
            "contract net",
            "algorithm"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "The Second Artillery Engineering College,Xi'an ,China"
            },
            {
                "name": "LIU Ying",
                "org": "The Second Artillery Engineering College,Xi'an ,China"
            },
            {
                "name": "PEI Ying",
                "org": "The Second Artillery Engineering College,Xi'an ,China"
            }
        ],
        "venue": "Fire Control & Command Control",
        "year": 2011
    },
    "2jMN6nS6": {
        "id": "2jMN6nS6",
        "title": "Investigation into Multi-time Missile Warfare Based on Markov Chain",
        "abstract": "Markov chain can effectively solve the problem of effect prediction about the multi-time missile warfare,and better multi-time missile warfare can be arranged.On some supposition,the mathematical model of multi-time missile warfare based on Markov chain is built,an example is analyzed,and the feasibility of the method is verified.",
        "keywords": [
            "missile warfare",
            "Markov chain",
            "multi-time",
            "effect prediction"
        ],
        "authors": [
            {
                "name": "Wang Tong",
                "org": "The Second Artillery Engineering College,Xi'an ,China"
            },
            {
                "name": "Yang Ping",
                "org": "The Second Artillery Engineering College,Xi'an ,China"
            },
            {
                "name": "Ouyang Haibo",
                "org": "The Second Artillery Engineering College,Xi'an ,China"
            }
        ],
        "venue": "Tactical Missile Technology",
        "year": 2011
    },
    "sQu5ck0h": {
        "id": "sQu5ck0h",
        "title": "An Optimization Model of Transportation Scheme in Preoperational Preparations of Conventional Missile",
        "abstract": "The arrange of transport time and transport line of vehicle in conventional missile turn plan is a combinatorial optimization problem when the operational plan is drawn up.In the paper,the factors of node conflict,vehicle hiding,task time limitation and road capacity are considered.An optimization model of transport scheme is built based on military operations and uncertain programming theory.This research helps for promoting fight efficiency of conventional missile and survivability of army.",
        "keywords": [
            "conventional missile",
            "optimization model",
            "transportation scheme",
            "uncertain programming theory"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "The Second Artillery Engineering College, Xi'an,China"
            },
            {
                "name": "LIU Wei-dong",
                "org": "The Second Artillery Engineering College, Xi'an,China"
            },
            {
                "name": "LI Ming-yu",
                "org": "The Second Artillery Engineering College, Xi'an,China"
            }
        ],
        "venue": "Fire Control and Command Control",
        "year": 2007
    },
    "ucObiN2P": {
        "id": "ucObiN2P",
        "title": "Study on improved algorithm on calculating blockage probability of airdrome with sub-munition carrier warhead",
        "abstract": "Using submunition to block the airdrome is an important question for discussion currently, so calculating the blockage probability accurately is very important. After the falling points were simulated, each submunition's kill radius was converted into effective kill radius of the judging region, and it was judged if there was a minimum leave window (MLW) in the judging region. Then the judging region was moved by a certain interval, finally, the blockage probability of airdrome was calculated. This algorithm was put forward to improve on the insufficiency in some papers, and the example shows that this method is accurate, fast and feasible.",
        "keywords": [
            "Airdrome runway",
            "Blockage probability",
            "Effective kill radius",
            "Sub-munition"
        ],
        "authors": [
            {
                "name": "WANG Xiao-mei",
                "org": "Second Artillery Engineering College Xi An(Second Artillery Engineering College,The Second Artillery Engineering College,The Second Artillery Engineering Institute,Second Artillery Engineering Institute),Xi An,China"
            },
            {
                "name": "Jiangrui Gao",
                "org": "Second Artillery Engineering College Xi An(Second Artillery Engineering College,The Second Artillery Engineering College,The Second Artillery Engineering Institute,Second Artillery Engineering Institute),Xi An,China"
            },
            {
                "name": "Ping Yang",
                "org": "Second Artillery Engineering College Xi An(Second Artillery Engineering College,The Second Artillery Engineering College,The Second Artillery Engineering Institute,Second Artillery Engineering Institute),Xi An,China"
            },
            {
                "name": "WU Li-na",
                "org": "PLA 96630 Unit(Unit 96630 of PLA,Troop 96630 of PLA,Unit 96630 of the PLA,PLA 96630 Unit),Beijing,China"
            }
        ],
        "venue": "Xitong Fangzhen Xuebao / Journal of System Simulation",
        "year": 2009
    },
    "r0mcwWM6": {
        "id": "r0mcwWM6",
        "title": "Study of Missile Operational Model Base's Design Based on UML",
        "abstract": "Missile operational model base is a reusable simulation resource base,the paper analyses model base's concept from system requirements,static modeling and dynamic modeling by UML for the purpose of raising the development's speed and benefit.According to analysis,the efficiency and quality of model base developed can be raised by UML.",
        "keywords": [
            "model base",
            "object-oriented",
            "UML",
            "missile operation"
        ],
        "authors": [
            {
                "name": "Wang Tong",
                "org": "The Second Artillery Engineering College,Xi'an "
            },
            {
                "name": "Yang Ping",
                "org": "The Second Artillery Engineering College,Xi'an "
            },
            {
                "name": "Zhao Hailong",
                "org": "The Second Artillery Engineering College,Xi'an "
            },
            {
                "name": "Ouyang Haibo",
                "org": "The Second Artillery Engineering College,Xi'an "
            },
            {
                "name": "Xu Zibin",
                "org": "The Second Artillery Engineering College,Xi'an "
            }
        ],
        "venue": "Ship Electronic Engineering",
        "year": 2011
    },
    "eGG1LHHt": {
        "id": "eGG1LHHt",
        "title": "Research on Batch Testing Technology of the Conventional Missile",
        "abstract": "Testing amount of quantity qualified conventional missiles in a short time is an objective request in the future battle.This paper joins together the battle of the missile corps the actual circumstance,analyzing the current technique the problem that battlefield face when testing,the method that put forward the some the reformation.Proceed to the technique battlefield the test equipment reforms,increasing well-trained degree of the personnel,by using the concurrent technology and the critical path technology and establishing at the same time the wartime meets an emergency the test process especially the missile batch testing technology to optimize missile testing procedure that can increase the testing speed greatly and shorten the testing time,it can give some advice for the build of the technical position hereafter.also for future the design of the normal regulations guided missile with researched to manufacture to put forward the higher request.",
        "keywords": [
            "conventional missile",
            "PERT",
            "critical path",
            "batch testing",
            "concurrent technology"
        ],
        "authors": [
            {
                "name": "LI Ming-yu",
                "org": "The Second Artillery Engineering College,Xi'an ,China"
            },
            {
                "name": "YANG Ping",
                "org": "The Second Artillery Engineering College,Xi'an ,China"
            },
            {
                "name": "BI Yi-ming",
                "org": "The Second Artillery Engineering College,Xi'an ,China"
            }
        ],
        "venue": "Fire Control and Command Control",
        "year": 2006
    },
    "yaHH2cDp": {
        "id": "yaHH2cDp",
        "title": "Decision-making model of tactics maneuver agent based on fuzzy Markov decision theory",
        "abstract": "For the background of maneuver operational simulation, the problem of optimal maneuver decision based on agent theory is studied. The conventional Markov decision model is extended. A fuzzy tactics maneuver decision-making model is proposed. The model defines the fuzzy state space, the fuzzy state transfer regularity and decision lucre, which preferably describes the information processing of fuzzy cognition, analysis and judgement under attack threaten circumstance in realistic operations. Further, reinforcement learning is introduced to solve the model when the state transfer regularity cannot make sure. Dynamic classify of state space, identification of observation state and Q-learning with prior knowledge are researched in reinforcement learning process. The simulation experiment is carried out and the result testifies the validity of the model and algorithm.",
        "keywords": [
            "Agent",
            "Fuzzy theory",
            "Markov decision theory",
            "Modeling",
            "Reinforcement learning",
            "Tactics maneuver decision"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "Second Artillery Engineering College Xi An(Second Artillery Engineering College,The Second Artillery Engineering College,The Second Artillery Engineering Institute,Second Artillery Engineering Institute),Xi An,China"
            },
            {
                "name": "BI Yi-ming",
                "org": "Second Artillery Engineering College Xi An(Second Artillery Engineering College,The Second Artillery Engineering College,The Second Artillery Engineering Institute,Second Artillery Engineering Institute),Xi An,China"
            },
            {
                "name": "LIU Wei-dong",
                "org": "Second Artillery Engineering College Xi An(Second Artillery Engineering College,The Second Artillery Engineering College,The Second Artillery Engineering Institute,Second Artillery Engineering Institute),Xi An,China"
            }
        ],
        "venue": "Xi Tong Gong Cheng Yu Dian Zi Ji Shu/Systems Engineering and Electronics",
        "year": 2008
    },
    "PDlFy8Ni": {
        "id": "PDlFy8Ni",
        "title": "Application of D-S Theory for Evaluation of Warhead Combat Efficiency",
        "abstract": "According to the problems of the evaluation of warhead combat efficiency,an eveluation method based on D-S theory is introduced.The reasonable index system of warhead combat efficiency and the reasonable mass function are constructed.Finally,the comprehensive evaluation of the object from the lower-level index are gotten.This method can provide an academic foundation for the decider to make right operational decision.",
        "keywords": [
            "efficiency index",
            "warhead",
            "D-S theory",
            "mass function"
        ],
        "authors": [
            {
                "name": "Wang Xiaomei",
                "org": "The Second Artillery Engineering College,Xi'an ,China"
            },
            {
                "name": "Yang Ping",
                "org": "The Second Artillery Engineering College,Xi'an ,China"
            },
            {
                "name": "Liu Weidong",
                "org": "The Second Artillery Engineering College,Xi'an ,China"
            }
        ],
        "venue": "Tactical Missile Technology",
        "year": 2009
    },
    "dBuFGUnB": {
        "id": "dBuFGUnB",
        "title": "Effects of chemotherapy on bone marrow mesenchymal stem cells of colorectal cancer patients",
        "abstract": "Objective To investigate the Effects of chemotherapy on biological behaviour of bone marrow mesenchymal stem cells of colorectal cancer patients. Methods The bone marrows of 43 colorectal patients were collected pre-and post chemotherapy for separation and culture of MSC. The morphology and growth of MSC were observed. The number of colony forming unit-fibroblast (CFU-F) was counted. The adhesive function of MSC was assayed and the growth of colony forming unit-mixed hematopoietic cells (CFU-Mix) on the MSC layer was observed. The concentration of IL-6\u3001SCF\u3001FLT-3L protein in the MSC culture supernatant were detected by ELISA assay. Bone marrows of 10 healthy adults in the same period of time were acted as the control. Results The number of CFU-F was decreased and the ability to support hematopoiesis was declined after chemotherapy. The adhesive rate of BMSC was decreased significantly. There was significant difference among three groups, while no significant difference was found between pre-chemotherapy and normal control. There was significant difference among three groups in the concentration of IL-6\u3001SCF\u3001FLT-3L protein in the MSC culture supernatant. Conclusions Bone marrow mesenchymal stem cells of colorectal cancer patients can be damaged by chemotherapy. The decreased expression of haematogenesis factors may play an important role in the pathogenesis.",
        "keywords": [
            "Colorectal cancer",
            "Cell culture",
            "Bone marrow mesenchymal stem cells"
        ],
        "authors": [
            {
                "name": "WANG Hui",
                "org": " Department of Gastrointestinal Surgery, Guangzhou First Municipal People's Hospital, Guangzhou "
            },
            {
                "name": "CAO Jie",
                "org": " Department of Gastrointestinal Surgery, Guangzhou First Municipal People's Hospital, Guangzhou "
            },
            {
                "name": "YANG Ping",
                "org": " Department of Gastrointestinal Surgery, Guangzhou First Municipal People's Hospital, Guangzhou "
            }
        ],
        "venue": "Lingnan Modern Clinics in Surgery",
        "year": 2007
    },
    "QNABMgVe": {
        "id": "QNABMgVe",
        "title": "Expressions of nudear-kappaB and cyclooxygenase-2 mRNA and their correlations with clinicopathologic parameters in colorectal cancer",
        "abstract": "Objective To investigate the expressions of nuclear factor-kappa B (NF-\u03baB) and cyclooxygenase-2 (COX-2) mRNA in colorectal cancer (CRC) and their correlations with clinicopathologic parameters. Methods The expression levels of NF-\u03baB and COX-2 mRNA were detected by real-time RT-PCR (SYBR Green \u2160) in the colorectal cancer tissues and normal paracancerous tissues from 58 patients. Results The expression rates and levels of NF-\u03baB and COX-2 mRNA were significantly higher in colorectal cancer tissues than in the normal paracancerous tissues (P < 0.01 and P < 0.05). The deeper the infiltration of the cancer,the higher the expression levels of NF-\u041aB and COX-2 mRNA. NF-\u03baB mRNA expression was related with lymph metastasis. The expression of NF-\u03baB was positively related with that of COX-2 (r = 0.417,P = 0.001). Conclusions NF-\u03baB and COX-2 mRNA are highly expressed in the colorectal cancer tissues. The expression levels of NF-\u03baB and COX-2 are positively related and associated with lymph metastasis and the infiltraion degree of colorectal cancer.",
        "keywords": [
            "COX-2",
            "Intestinal neoplasms",
            "NF-\u03baB"
        ],
        "authors": [
            {
                "name": "SUN Zheng",
                "org": ". Department of Gastrointestinal Surgery,Affiliated Guangzhou First People's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "CAO Jie",
                "org": ". Department of Gastrointestinal Surgery,Affiliated Guangzhou First People's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "YANG Ping",
                "org": ". Department of Gastrointestinal Surgery,Affiliated Guangzhou First People's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "ZHANG Wei-jian",
                "org": ". Department of Gastrointestinal Surgery,Affiliated Guangzhou First People's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "LI Jie",
                "org": ". Department of Gastrointestinal Surgery,Affiliated Guangzhou First People's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "ZHANG Long",
                "org": ". Department of Gastrointestinal Surgery,Affiliated Guangzhou First People's Hospital,Guangzhou Medical College,Guangzhou ,China"
            }
        ],
        "venue": "The Journal of Practical Medicine",
        "year": 2010
    },
    "y7M0STh7": {
        "id": "y7M0STh7",
        "title": "Experience of diagnosis and treatment of foreign bodies in the lower digestive tract: A report of 25 cases",
        "abstract": "Objective To evaluate the experience of diagnosis and therapy in patients with foreign bodies in lower digestive tract. Methods A total of 25 cases with foreign bodies in lower digestive tract from Sep. 2001 to Dec. 2011 was analyzed retrospectively. Results Of all cases,18 cases (72%) of them were undertaken abdominal operation to remove the foreign bodies. 5 cases of rectal foreign body were removed from the anus under sacral anesthesia. 2 cases were eliminated from the body naturally after conservative treatment. Conclusion It is important for the different types of intestinal non-traumatic foreign bodies to perform the appropriate treatment measures.",
        "keywords": [
            "Diagnosis",
            "Digestive tract",
            "Foreign body",
            "Therapy"
        ],
        "authors": [
            {
                "name": "Wang Qiang",
                "org": ". Department of Gastrointestinal Surgery, the First Municipal People's Hospital of Guangzhou, Guangzhou "
            },
            {
                "name": "Cao Jie",
                "org": ". Department of Gastrointestinal Surgery, the First Municipal People's Hospital of Guangzhou, Guangzhou "
            },
            {
                "name": "Chen Xiwen",
                "org": ". Department of Gastrointestinal Surgery, the First Municipal People's Hospital of Guangzhou, Guangzhou "
            },
            {
                "name": "Yang Ping",
                "org": ". Department of Gastrointestinal Surgery, the First Municipal People's Hospital of Guangzhou, Guangzhou "
            }
        ],
        "venue": "Lingnan Modern Clinics in Surgery",
        "year": 2011
    },
    "HsktlHrm": {
        "id": "HsktlHrm",
        "title": "To study the relationship between nitric oxide and radix salviae miltiorrhizae and agrimony in treatment of arrhythmia",
        "abstract": "Objective:To study the relationship between nitric oxide and single traditional Chinese drug radix salviae miltiorrhizae and agrimony,in treatment of arrhythmia.Methods:rats model were used to predict effects of the different dose single radix salviae miltiorrhizae and agrimony respectivelyin the study.Results:both thd lower dose radix salviae miltiorrhizae and agrimony are efficacious to antiarrhythmia.The higher salviae miltiorrhizae can reduce blood fat and viscosity.Conclusion:endothelium cells adjust millieuinterne and secreted medium result in the reverse of function of endothelium cells.Therefore the antiarrhythmia mechanism of radix salviae miltiorrhizae and agrimony related to the synthesize and secretion of nitric oxide.",
        "keywords": [
            "arrhythmia",
            "nitric oxide",
            "agrimony",
            "radix salviae miltiorrhizae"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "The Hebei province People's Hospital,Shijiazhuang Hebei ,China"
            },
            {
                "name": "SHEN Hai-ping",
                "org": "The Hebei province People's Hospital,Shijiazhuang Hebei ,China"
            },
            {
                "name": "ZHANG Dong-zhen",
                "org": "The Hebei province People's Hospital,Shijiazhuang Hebei ,China"
            },
            {
                "name": "LI Feng-yun",
                "org": "The Hebei province People's Hospital,Shijiazhuang Hebei ,China"
            }
        ],
        "venue": "Chinese Journal of Basic Medicine in Traditional Chinese Medicine",
        "year": 2006
    },
    "oeD0MbtL": {
        "id": "oeD0MbtL",
        "title": "Expression of ATDC protein on Ovarian Carcinoma and its Relationship With \u03b2-catenin Protein",
        "abstract": "Objective:To study ATDC protein expression on Ovarian Carcinoma,evaluate its possible role in the tumorigenesis and progression of Ovarian Carcinoma,and investigate its relationship with the expression of \u03b2-catenin protein.Methods:The expression of ATDC protein and \u03b2-catenin protein in tissue of Ovarian Carcinoma,benign epithelial ovarian neoplasia,and normal ovary tissues were detected by the immunohistochemistry method.The possible relationship between two protein's expression and clinicopathological parameters were analyzed with SPSS software for Windows.Results:The expression of ATDC protein gradually up-regulated from normal ovary tissues to benign epithelial ovarian neoplasia to Ovarian Carcinoma(P<0.01).Spearman rank correlation analysis showed a strong positive correlation between the expression of ATDC and \u03b2-catenin protein(r=0.71,P<0.05).Conclusion:ATDC plays a considerable promotion action in genesis and development of Ovarian Carcinoma;Abnormal expression of ATDC might have promotion effect on invasion and metastasis of Ovarian Carcinoma and act as an effective and objective marker to indicate the pathobiological behavior of Ovarian Carcinoma.The expression of ATDC was positively correlated to the \u03b2-catenin.Furthermore \u03b2-catenin may be an effective protein of ATDC gene.",
        "keywords": [
            "\u03b2-catenin",
            "Ovarian Carcinoma",
            "ATDC",
            "immunohistochemistry",
            "Ataxia telangiectasia group D complement gene"
        ],
        "authors": [
            {
                "name": "SHENG Li-hong",
                "org": "Guangzhou First Municipal People's Hospital,Guangzhou,Guangdong "
            },
            {
                "name": "WANG Hui",
                "org": "The Sixth Affiliated Hospital of Sun Yat-Sen Universsity,Guangzhou,Guangdong "
            },
            {
                "name": "YANG Ping",
                "org": "Guangzhou First Municipal People's Hospital,Guangzhou,Guangdong "
            }
        ],
        "venue": "Journal of Gannan Medical University",
        "year": 2011
    },
    "n0jIEOVQ": {
        "id": "n0jIEOVQ",
        "title": "Different expression and significance of C-erb B-2,nm23,bcl-2 and p53 protein Markers in colorectal cancer",
        "abstract": "Objective:To investigate the different expression and significance of C-erb B-2,nm23,bcl-2 and p53 protein Markers in colorectal carcinoma with tissue microarray technology.Methods:Tissue microarray were established to detect C-erb B-2,nm23,bcl-2 and p53 protein expression in 80 cases of colorectal carcinoma\u300116 cases colorectal adenoma and 16 case of Haemorrhoids(PPH) in the same period of time as the control.The expressions of C-erb B-2,nm23,bcl-2 and!p53 were determined immunohistochemically,and TLNEL technique was used to detect apoptosis.The relationship to clinicopathological factors such as differentiation grades and lymph nodes metastases were observed.Results:The expressions of C-erb B-2 protein was significanlly higher in colorectal carcinomas than in adenoma and normal colorectal tissues(P<0.01). Clinicopathological analysis of patients showed that the increase of C-erb B2 protein expression were not associated with age,sex and serum CEA levels of the patients and sites,sizes,histological classification,but were associated with differentiation grades,pathological stages and lymph nodes metastases.A positive correlation was observed between C-erb B-2 and bcl-2,and a negative correlation was observed between C-erb B-2 and nm23\u3001p53 protein\u3001apoptosis(P<0.01).Conclusions:The overexpression of C-erb B-2 and bcl-2 protein in colorectal carcinomas overexpression,which may lead to degradation of p53 and low expression of nm23,may play an important role in the pathogenesis,progression,invasion,and metastases of the tumor.Determination of C-erb B-2,nm23,bcl-2 and p53 protein Markers would be helpful for decision making of adjuvant therapy.",
        "keywords": [
            "C-erb B-2",
            "Carcinogenesis",
            "Colorectal carcinoma",
            "oncoproteins"
        ],
        "authors": [
            {
                "name": "WANG Hui",
                "org": "Gastrointestinal Surgery Department,Affiliated Guangzhou first municipal people's Hospital,Guangzhou Medical College,Guangzhou "
            },
            {
                "name": "CAO Jie",
                "org": "Gastrointestinal Surgery Department,Affiliated Guangzhou first municipal people's Hospital,Guangzhou Medical College,Guangzhou "
            },
            {
                "name": "YANG Ping",
                "org": "Gastrointestinal Surgery Department,Affiliated Guangzhou first municipal people's Hospital,Guangzhou Medical College,Guangzhou "
            },
            {
                "name": "TAN Ming-hua",
                "org": "Gastrointestinal Surgery Department,Affiliated Guangzhou first municipal people's Hospital,Guangzhou Medical College,Guangzhou "
            }
        ],
        "venue": "Journal of Gannan Medical University",
        "year": 2007
    },
    "GwKHjTnQ": {
        "id": "GwKHjTnQ",
        "title": "Effects of in vitro tranfection of KISS-1 gene on invasion and migration of SW 480 cell line",
        "abstract": "Objective To investigate the effects of tumormetastasis suppressor gene KiSS-1 on the invasionand migration abilities of colon cancer SW480 cells. Methods Eukaryotic expression plasmid containing KISS-1,pRc/CMV2-KISS-1,was introduced into E.coli DH5\u03b1 and amplified.The plasmid was purified and identified by restrictive enzyme digestion. Plasmid pRc/CMV2-KISS-1 was transfected into SW480 cells,and positive cell clones(SW480-KISS-1)were selected and amplified.plasmid-transfected SW480 cells(SW480-pRc/CMV2)and normal SW480 cells were set as control.Reverse transcription-polymerase chain reaction(RT-PCR)was applied to assess the expression of KISS-1.Proliferation\u3001invasion and migration ability of SW480 cells were measured before and after transfection by MTT assay and cell invasion assay, respectively. Results SW 480 cell transfected with pRc/CWV2-KISS-1 Was approved to express KISS-1.while KISS-1 expression was completety absent in the control group. The expression of KISS-1 significantly inhibited invasion; migration of SW480 cells in the experimental group(P<0.01). Conclusion KiSS-1 gene can significantly inhibit the invasion and migration abilities of colon cancer SW480 cells, which may play a key role in metastasis of colon cancer.",
        "keywords": [
            "SW480 cell",
            "Invasion",
            "Colon carcinoma",
            "Migration",
            "KISS-1 gene"
        ],
        "authors": [
            {
                "name": "Li Wang-lin",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhoufirst municipal people's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "Cao Jie",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhoufirst municipal people's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "Zhang Wei-jian",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhoufirst municipal people's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "Yang Ping",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhoufirst municipal people's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "Chen Xi-wen",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhoufirst municipal people's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "Wang Qiang",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhoufirst municipal people's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "Liang Li-yuan",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhoufirst municipal people's Hospital,Guangzhou Medical College,Guangzhou ,China"
            }
        ],
        "venue": "Lingnan Modern Clinics in Surgery",
        "year": 2011
    },
    "4qOwrqHH": {
        "id": "4qOwrqHH",
        "title": "Cloning of human FHIT gene and construction of eukaryotic expression plasmid",
        "abstract": "Objective To clone the gene of Fragile histidine triad (FHIT) and to construct its eukaryotic expression plasmid pRcCMV-FHIT. Methods Total RNA was extracted from peripheral blood mononuclear cells (PBMCs). RT-PCR was used to amplify FHIT cDNA open reading frame (ORF) sequence. The PCR products were inserted into pGEM-T, and the resulted plasmid was transformed into bacillus coli DH5\u03b1. The positive clone was selected and identified by colony PCR, digestion of internal restriction enzyme,and sequencing. The FHIT gene fragment obtained from pGEMT -FHIT was cloned into eulcaryotic expression plasmid pRc/CMV2. The positive clone was selected and identified by colony PCR and digestion of internal restriction enzyme. Results The PCR amplification yielded a single band of about 781 base pairs, sequence analysis of the PCR products revealed that it is consistent with that of the references published (GenBank NM_002012.1). Conclusions The human FHIT gene was cloned, and its eukaryotic expression plasmid pRcCMV-FHIT  was constructed. It will be beneficion for the further studies on effects of liposome-mediated transfection of FHIT gene to colon Cancer Cell Line SW480.",
        "keywords": [
            "Eukaryotic expression plasmid",
            "Fragile histidine triad",
            "Gene cloning"
        ],
        "authors": [
            {
                "name": "Yang Ping",
                "org": " Department of Gastrointestinal Surgery, Affiliated Guangzhou First Municipal People's Hospital,Guangzhou Medical College , Guangzhou "
            },
            {
                "name": "Cao Jie",
                "org": " Department of Gastrointestinal Surgery, Affiliated Guangzhou First Municipal People's Hospital,Guangzhou Medical College , Guangzhou "
            },
            {
                "name": "Qian Yue-jun",
                "org": " Department of Gastrointestinal Surgery, Affiliated Guangzhou First Municipal People's Hospital,Guangzhou Medical College , Guangzhou "
            },
            {
                "name": "Peng Yan",
                "org": " Department of Gastrointestinal Surgery, Affiliated Guangzhou First Municipal People's Hospital,Guangzhou Medical College , Guangzhou "
            },
            {
                "name": "Sun Zheng",
                "org": " Department of Gastrointestinal Surgery, Affiliated Guangzhou First Municipal People's Hospital,Guangzhou Medical College , Guangzhou "
            },
            {
                "name": "Li Wang-lin",
                "org": " Department of Gastrointestinal Surgery, Affiliated Guangzhou First Municipal People's Hospital,Guangzhou Medical College , Guangzhou "
            },
            {
                "name": "Wang Qiang",
                "org": " Department of Gastrointestinal Surgery, Affiliated Guangzhou First Municipal People's Hospital,Guangzhou Medical College , Guangzhou "
            },
            {
                "name": "Tan Ming-hua",
                "org": " Department of Gastrointestinal Surgery, Affiliated Guangzhou First Municipal People's Hospital,Guangzhou Medical College , Guangzhou "
            }
        ],
        "venue": "Lingnan Modern Clinics in Surgery",
        "year": 2009
    },
    "FosT35Su": {
        "id": "FosT35Su",
        "title": "Application of tumor-free technology in laparoscopic radical operation for colorectal cancer",
        "abstract": "Objective To investigate the clinical value of tumor-free technology in laparoscopic resection of colorectal cancer. Methods The clinical data of 59 patients with colorectal cancer who underwent laparoscopic radical surgery with tumor-free technology were retrospectively analyzed and the operative methods and follow-up results were reviewed. Results All operation were successfully completed, in which fifty eight patients underwent total mesorectal excision (TME) and colorectal anastomosis, one patient underwent abdominal-perineal resection (Miles). The intraoperative blood loss was 50-l50 mL, the average 80 was mL. The mean operative time was 120 min, and the mean intestinal function recovery time was 22 h. No postoperative anastomotic leakage, anastomotic stricture and anastomotic bleeding were found. All patients were discharged and followed up for an average of 25 months. Local recurrence was found in 2 cases. Liver metastasis occurred in 1 case. No lung metastasis happened. Conclusion Tumor-free application in laparoscopic radical resection of colorectal cancer is safe, reliable, with less blood loss, shorter hospital stay, faster recovery of intestinal function.",
        "keywords": [
            "Laparoscopy",
            "Tumor-free technology",
            "Rectal cancer"
        ],
        "authors": [
            {
                "name": "Li Wanglin",
                "org": " Department of Gastrointestinal Surgery, The First Affilated Municipal People's Hospital of Guangzhou, Guangzhou Medical College,Guangzhou "
            },
            {
                "name": "Cao Jie",
                "org": " Department of Gastrointestinal Surgery, The First Affilated Municipal People's Hospital of Guangzhou, Guangzhou Medical College,Guangzhou "
            },
            {
                "name": "Zhang Weijian",
                "org": " Department of Gastrointestinal Surgery, The First Affilated Municipal People's Hospital of Guangzhou, Guangzhou Medical College,Guangzhou "
            },
            {
                "name": "Yang Ping",
                "org": " Department of Gastrointestinal Surgery, The First Affilated Municipal People's Hospital of Guangzhou, Guangzhou Medical College,Guangzhou "
            },
            {
                "name": "Wang Qiang",
                "org": " Department of Gastrointestinal Surgery, The First Affilated Municipal People's Hospital of Guangzhou, Guangzhou Medical College,Guangzhou "
            },
            {
                "name": "Zhong Junbin",
                "org": " Department of Gastrointestinal Surgery, The First Affilated Municipal People's Hospital of Guangzhou, Guangzhou Medical College,Guangzhou "
            },
            {
                "name": "Yang Jianrong",
                "org": " Department of Gastrointestinal Surgery, The First Affilated Municipal People's Hospital of Guangzhou, Guangzhou Medical College,Guangzhou "
            },
            {
                "name": "Zhang Tong",
                "org": " Department of Gastrointestinal Surgery, The First Affilated Municipal People's Hospital of Guangzhou, Guangzhou Medical College,Guangzhou "
            }
        ],
        "venue": "Lingnan Modern Clinics in Surgery",
        "year": 2012
    },
    "iq1KbbqN": {
        "id": "iq1KbbqN",
        "title": "Combination therapy with S-1 and irinotecan for patients with advanced colorectal cancer",
        "abstract": "Objective To evaluate the efficacy and safety of S-1 combined with irinotecan in the treatment of patients with advanced colorectal cancer.Methods 64 patients with advanced colorectal cancer were randomly divided into two groups.The treatment group was administrated with S-1 plus irinotecan(irinotecan 180 mg/m2 infused intravenously for 2 h day 1;S-1 taken orally 80 mg/m2 day 1 to 14,repeated 21 days).The control group was administrated with oxaliplatin\u3001CF and 5-Fu(oxaliplatin 85 mg/m2 infused intravenously for 3 h day 1,CF 200 mg/m2 and 5-Fu 400 mg/m2 infused intravenously day 1 to 5,repeated 21 days)\u3002The efficacy and toxicities were reviewed after at least 4 cycles of chemotherapy.Results The effective rates were 56.25% and 31.25% in the treatment group and control group respectively.Treatment group was better than control group(P > 0.05).The main toxicities included bone marrow suppression,nausea and vomiting,diarrhea,stomatitis.Conclusion S-1 combined Irinotecan in the treatment of advanced colorectal cancer is effective and has mild side effects.It helps the patients improve their survival rate and quality of life;it may be an effective chemotherapy.",
        "keywords": [
            "Colorectal neoplasms",
            "Safety",
            "Irinotecan",
            "S-1",
            "Therapeutic effect"
        ],
        "authors": [
            {
                "name": "ZHONG Jun-bin",
                "org": ".Gastrointestinal Surgery,Guangzhou First Municipal People's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "CAO Jie",
                "org": ".Gastrointestinal Surgery,Guangzhou First Municipal People's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "YANG Ping",
                "org": ".Gastrointestinal Surgery,Guangzhou First Municipal People's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "ZHANG Wei-jian",
                "org": ".Gastrointestinal Surgery,Guangzhou First Municipal People's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "ZENG Shan-qi",
                "org": ".Gastrointestinal Surgery,Guangzhou First Municipal People's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "SUN Zheng",
                "org": ".Gastrointestinal Surgery,Guangzhou First Municipal People's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "ZHANG Tong",
                "org": ".Gastrointestinal Surgery,Guangzhou First Municipal People's Hospital,Guangzhou Medical College,Guangzhou ,China"
            }
        ],
        "venue": "The Journal of Practical Medicine",
        "year": 2012
    },
    "lJIsJ9jK": {
        "id": "lJIsJ9jK",
        "title": "Suppression of APC production during apoptosis of human colorectal cancer cell line SW480 induced by gambogic acid",
        "abstract": "Objective To investigate the effect of gambogic acid on human colorectal cancer cell line SW480. Methods Methyl thiazolyl tetrazolium (MTT) assay was used to test the changes in the proliferation of SW480 cells cultured with different concentrations of gambogic acid for 24, 36 and 48 h in vitro. Cell-cycle kinetics and apoptosis were analyzed by flow cytometry (FCM). Western-blot was applied to examine the protein expression of APC. Results Gambogic acid with concentration greater than 1 \u03bcg/ml could significantly inhibit the proliferation of human colorectal cancer cell line SW480 and the effect was more prominent as time went on (P<0.01). The G2/M phase cells reached 54.74% with gambogic acid at concentration of 4 \u03bcg/ml. When SW480 cells were treated with gambogic acid at the concentration of 0, 0.5, 1 and 4 \u03bcg/ml, the rate of apoptosis of SW480 cell were (0.17\u00b10.08)%, (0.85\u00b10.19)%, (7.12\u00b11.21)%, and (15.87\u00b11.59)%, respectively. After SW480 cells were treated with 0, 0.5, 1 and 4 \u03bcg/ml gambogic acid for 24 h respectively, the level of APC protein increased as concentration increased (P<0.01). Conclusion Gambogic acid can significantly inhibit the proliferation and induces G2/M arrest in human colon cancer cell line SW480. The effect mechanism is related to the suppression of APC protein production.",
        "keywords": [
            "colonic neoplasms",
            "gambogic acid",
            "APC"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Department of Gastrointestinal Surgery, the First People\u2032s Hospital of Guangzhou, Guangzhou Medical University, Guangdong, Guangzhou , China"
            },
            {
                "name": "CAO Jie",
                "org": "Department of Gastrointestinal Surgery, the First People\u2032s Hospital of Guangzhou, Guangzhou Medical University, Guangdong, Guangzhou , China"
            },
            {
                "name": "ZHANG Tong",
                "org": "Department of Gastrointestinal Surgery, the First People\u2032s Hospital of Guangzhou, Guangzhou Medical University, Guangdong, Guangzhou , China"
            },
            {
                "name": "WANG Qiang",
                "org": "Department of Gastrointestinal Surgery, the First People\u2032s Hospital of Guangzhou, Guangzhou Medical University, Guangdong, Guangzhou , China"
            },
            {
                "name": "SUN Zheng",
                "org": "Department of Gastrointestinal Surgery, the First People\u2032s Hospital of Guangzhou, Guangzhou Medical University, Guangdong, Guangzhou , China"
            },
            {
                "name": "ZHANG Wei-jian",
                "org": "Department of Gastrointestinal Surgery, the First People\u2032s Hospital of Guangzhou, Guangzhou Medical University, Guangdong, Guangzhou , China"
            },
            {
                "name": "ZENG Shan-qi",
                "org": "Department of Gastrointestinal Surgery, the First People\u2032s Hospital of Guangzhou, Guangzhou Medical University, Guangdong, Guangzhou , China"
            }
        ],
        "venue": "Journal of Tropical Medicine",
        "year": 2013
    },
    "laHUv6c9": {
        "id": "laHUv6c9",
        "title": "Effect of gambogic acid on the proliferation of human colon carcinoma cell SW480 and the expression of VEGFR2",
        "abstract": "Objective:To investigate the effect of gambogic acid on human Colorectal Cancer Cell Line SW480 through suppression of VEGFR2 expression.Methods Methyl thiazolyl tetrazolium(MTT) assay was used to test the changes in the proliferation of SW480 cells cultured with different concentrations of gambogic acid for 24,36 and 48h in vito.Cell-cycle kinetics and apoptosis were analyzed by flow cytometry(FCM).Western-blot was applied to examine the protein expression of VEGFR2.Results:The proliferation of SW480 cells was obviously suppressed by gambogic acid in a concentration-and time-dependent manner.The cell was arrested at G2/M and apoptosis was induced.When SW480 cells were treated with gambogic acid at the concentration of 0\u30010.5\u30011.0\u30014.0\u03bcg/ml,the apoptosis rates of SW480 cell were(0.17\u00b10.08)%\u3001(0.85\u00b10.19)%\u3001(7.12\u00b11.21)%\u3001(15.87\u00b11.59)%,respectively.After SW480 cells were treated with 0\u30010.5\u30011.0\u30014.0\u03bcg/ml gambogic acid for 24h respectively,the level of VEGFR2 protein decreased as concentration increased(P<0.01).Conclusions:Gambogic acid can significantly inhibit the proliferation and induces G2/M arrest in human colon cancer cell line SW480.The effect mechanism is related to suppression of VEGFR2 expression.",
        "keywords": [
            "Gambogic acid",
            "Colonic neoplasms",
            "VEGFR2"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Department of Gastrointestinal Surgery,Affiliated Guangzhou first municipal people's Hospital, Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "CAO Jie",
                "org": "Department of Gastrointestinal Surgery,Affiliated Guangzhou first municipal people's Hospital, Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "ZHANG Tong",
                "org": "Department of Gastrointestinal Surgery,Affiliated Guangzhou first municipal people's Hospital, Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "WANG Qiang",
                "org": "Department of Gastrointestinal Surgery,Affiliated Guangzhou first municipal people's Hospital, Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "SUN Zheng",
                "org": "Department of Gastrointestinal Surgery,Affiliated Guangzhou first municipal people's Hospital, Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "ZHANG Wei-jian",
                "org": "Department of Gastrointestinal Surgery,Affiliated Guangzhou first municipal people's Hospital, Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "ZENG Shan-qi",
                "org": "Department of Gastrointestinal Surgery,Affiliated Guangzhou first municipal people's Hospital, Guangzhou Medical College,Guangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Basic Medicine in Traditional Chinese Medicine",
        "year": 2012
    },
    "M3HumGy4": {
        "id": "M3HumGy4",
        "title": "The roles of CCN2 and APC in colorectal cancer",
        "abstract": "Objective To investigate the roles of CCN2 and APC in colorectal cancer.Methods Immunohistochemical staining of CCN2 and APC were performed in 180 samples,including each 30 samples of normal rectum mucosa tissue,adjacent noncancerous tissue,adenoma of colorectum,non-metastatic colorectal carcinoma,metastatic colorectal carcinoma and distant metastasis tissue.Results The positive rates of CCN2 in non-metastatic colorectal carcinoma,metastatic colorectal carcinoma and distant metastasis tissues were 76.67%,73.33% and 70.00%,respectively,which were significantly higher than those in the mucosa tissue of normal rectum,adjacent noncancerous tissue,and adenoma of colorectum(X2=70.00,P=0.000).The positive rates of APC in adjacent noncancerous tissue,adenoma of colorectum and mucosa tissue of normal rectum,were 86.67%,76.67% and 90.00%,respectively,which were significantly higher than those in the non-metastatic colorectal carcinoma,metastatic colorectal carcinoma and distant metastasis tissue(X2=70.00,P=0.000).The expression of CCN2 was significantly correlated with the TNM neoplasm phasing and five-year survival(X2=4.689,P=0.03;X2=4.13,P=0.042),while the expression of APC and CCN2 was significantly negatively correlated(rs=-0.467,P=0.001).Conclusion CCN2 gene is a oncogene,of which expression is correlated with the clinical pathology of colorectal cancer.The expression of CCN2 in colorectal cancer may be regulated by Wnt signal pathway.",
        "keywords": [
            "Wnt signaling",
            "CCN2",
            "colorectal cancer",
            "APC"
        ],
        "authors": [
            {
                "name": "SUN Zheng",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou First Municipal People\u2032s Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "CAO Jie",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou First Municipal People\u2032s Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "LIANG Li-yuan",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou First Municipal People\u2032s Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "YANG Ping",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou First Municipal People\u2032s Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "ZHANG Tong",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou First Municipal People\u2032s Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "ZHANG Wei-jian",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou First Municipal People\u2032s Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "TANG Wei-biao",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou First Municipal People\u2032s Hospital,Guangzhou Medical College,Guangzhou ,China"
            }
        ],
        "venue": "Guangdong Medical Journal",
        "year": 2012
    },
    "jX2UGtuW": {
        "id": "jX2UGtuW",
        "title": "Different expression of FHIT mRNA in colorectal cancer and it's correlation with apoptosis",
        "abstract": "Objective To investigate the correlation between different expression of FHIT mRNA and apoptosis in colorectal carcinoma with tissue microarray technology. Methods Tissue microarray was established to detect FHIT mRNA expression in 80 cases of colorectal carcinoma?16 cases colorectal adenoma and 16 case of hemorrhoidal tissue in the same period of time as the control. FHIT mRNA was detected by using in situ hybridization,and TUNEL technique was used to detect apoptosis index of rectal cancer cell. Results The expressions of FHIT mRNA were significanlly lower in colorectal carcinomas than in adenoma and normal colorectal tissues (P<0.01). Clinicopathological analysis of patients showed that the decrease of FHIT mRNA expression were not associated with age,sex and serum CEA levels of the patients and sites,sizes,histological classification, but were associated with differentiation grades, pathological stages and lymph nodes metastases. A positive correlation was observed between FHIT mRNA and apoptosis (P<0.01). The average survival time of patients with higher expression of survivin mRNA was 42.7 months, and that of patients with lower expression of survivin mRNA was 29.8 months; 5-year survival rate of the former (88.10%,37/42) was significantly lower than that of the latter (74.19%,23/31) (P<0.05).Conclusions FHIT gene may play an important role in the regulation of apoptosis, Decreased FHIT expression may play a role in the oncogenesis and progression of colorectal carcinoma.",
        "keywords": [
            "Apoptosis of cells",
            "Fragile histidine triad",
            "Colorectal carcinoma"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": " Department of Gastrointestinal Surgery Affiliated Guangzhou first municipal people's Hospital, Guangzhou Medical College, Guangzhou "
            },
            {
                "name": "CAO Jie",
                "org": " Department of Gastrointestinal Surgery Affiliated Guangzhou first municipal people's Hospital, Guangzhou Medical College, Guangzhou "
            },
            {
                "name": "WANG Hui",
                "org": " Department of Gastrointestinal Surgery Affiliated Guangzhou first municipal people's Hospital, Guangzhou Medical College, Guangzhou "
            },
            {
                "name": "LI Wanglin",
                "org": " Department of Gastrointestinal Surgery Affiliated Guangzhou first municipal people's Hospital, Guangzhou Medical College, Guangzhou "
            },
            {
                "name": "TAN Minghua",
                "org": " Department of Gastrointestinal Surgery Affiliated Guangzhou first municipal people's Hospital, Guangzhou Medical College, Guangzhou "
            }
        ],
        "venue": "Lingnan Modern Clinics in Surgery",
        "year": 2007
    },
    "hb3ChzV6": {
        "id": "hb3ChzV6",
        "title": "Activation of caspase-8 during apoptosis of human colorectal cancer cell line SW480 induced by oxaliplatin",
        "abstract": "Objective To investigate the effect of oxaliplatin on human colorectal cancer cell line SW480 through up-regulated expression of caspase-8.Methods Methyl thiazolyl tetrazolium(MTT)assay was used to measure the proliferation of SW480 cells cultured with different concentrations of oxaliplatin for 24,36 and 48 h in vitro.Cell-cycle kinetics and apoptosis were analyzed by flow cytometry(FCM).The changes of pro-caspase-8,caspase-8 mRNA and relative activity of caspase-8 were analyzed by Western-blot,semi-quantitative RT-PCR,and colorimetric assay with PAN-labelled substrate,respectively.Results The proliferation of SW480 cells was significantly suppressed by oxaliplatin in a concentration-and time-dependent manner.The cell was arrested at G2/M and apoptosis was induced.When SW480 cells were treated with oxaliplatin at the concentration of 0,0.03,4.0 and 100 \u03bcg/ml,the apoptosis rates of SW480 cell were(0.15\u00b10.09)%,(0.43\u00b10.17)%,(6.92\u00b10.81)% and(11.76\u00b11.25)%,respectively.After SW480 cells were treated with 0,0.03,4.0 and 100 \u03bcg/ml of oxaliplatin for 24 h respectively,the level of pro-caspase-3 protein decreased and caspase-3 mRNA increased as concentration increased(P<0.01).When cells were treated with oxaliplatin at the concentration of 4.0 \u03bcg/ml for 0.5,2,6,12 and 24 h,the caspase-8 activity began to rise at 2 h and reached the peak at 12 h(P<0.01).After cells were treated with oxaliplatin of different concentrations for 12 h,caspase-8 activity increased in a concentration-dependent manner(P<0.01).Conclusion Oxaliplatin can significantly inhibit the proliferation and induces G2/M arrest in human colon cancer cell line SW480.The mechanism is related to up-regulated expression of caspase-8.",
        "keywords": [
            "Colonic neoplasms Oxaliplatin Caspase-8"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": ",et al.Gastrointestinal Surgery Department,Affiliated Guangzhou First Municipal People's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "CAO Jie",
                "org": ",et al.Gastrointestinal Surgery Department,Affiliated Guangzhou First Municipal People's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "WANG Hui",
                "org": ",et al.Gastrointestinal Surgery Department,Affiliated Guangzhou First Municipal People's Hospital,Guangzhou Medical College,Guangzhou ,China"
            }
        ],
        "venue": "Guangdong Medical Journal",
        "year": 2007
    },
    "PgIqSMAw": {
        "id": "PgIqSMAw",
        "title": "Escherichia coli promotes recovery from dextran sulfate sodium-induced colitis in mice",
        "abstract": "AIM: To investigate the important role of intestinal microflora in the pathogenesis of inflammatory bowel disease by studying the effects of E.coli on dextran sulfate sodium(DSS)-induced colitis in mice.METHODS: BALB/c mice were given 3.5% DSS in the drinking water for 5 days to induce acute colitis.The control mice(n=6) did not drink DSS water.The mice subject to drinking DSS were randomly divided into 3 groups:(1) simple DSS treatment group;(2) bacteria-depleted mice treated with DSS alone;(3) bacteria-depleted mice treated with DSS+E.coli.Four aspects of the treatment response were evaluated in each group:(1) general conditions,including body weight,disease activity index(DAI) score,colon length and weight;(2) histological score;(3) chemical colorimetric detection of myeloperoxidase(MPO) activity in the diseased tissues;(4) the activation of NF-\u03baB detected by immune histochemistry.RESULTS: The bacteria-depleted mice that did not treat with E.coli were difficult to recover from DSS-induced colitis.Compared with non-treatment group,the general score,histological score and MPO activity in E.coli treatment group improved significantly(P<0.05).The activity of NF-\u03baB in E.coli treatment group was significantly higher than that in non-E.coli treatment group(P<0.05).CONCLUSION: Intestinal microbiota is necessary during the recovery from DSS-induced colitis.E.coli promotes the recovery from DSS-induced colitis in mice.The mechanism may be associated with NF-\u03baB activation.",
        "keywords": [
            "Inflammatory bowel disease",
            "NF-kappa B",
            "Bacteria-depleted mice",
            "Ulcerative colitis",
            "Escherichia coli"
        ],
        "authors": [
            {
                "name": "LI Wang-lin",
                "org": "Department of Gastrointestinal Surgery,First Municipal People's Hospital Affiliated to Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "CAO Jie",
                "org": "Department of Gastrointestinal Surgery,First Municipal People's Hospital Affiliated to Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "XIAO Huan-qing",
                "org": "Department of Gastrointestinal Surgery,First Municipal People's Hospital Affiliated to Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "ZHANG Wei-jian",
                "org": "Department of Gastrointestinal Surgery,First Municipal People's Hospital Affiliated to Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Gastrointestinal Surgery,First Municipal People's Hospital Affiliated to Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "ZHONG Jun-bin",
                "org": "Department of Gastrointestinal Surgery,First Municipal People's Hospital Affiliated to Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "ZHANG Tong",
                "org": "Department of Gastrointestinal Surgery,First Municipal People's Hospital Affiliated to Guangzhou Medical College,Guangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Pathophysiology",
        "year": 2012
    },
    "nb18w2xv": {
        "id": "nb18w2xv",
        "title": "Effects of neoadjuvant chemotherapy on expression of bcl-2\u3001bax in rectal cancer",
        "abstract": "Objective To investigate the effects of neoadjuvant chemotherapy on expression of bcl-2?bax in rectal cancer. Methods From July 2004 to July 2006,43 cases of local progressive rectal cancer were confirmed by colonoscopic biopsy before operation. The apoptosis index of rectal cancer cells was detected by TUNEL technique. The bcl-2, bax protein expression were detected by immunohistochemical citrate-microwave-SP method. The 2 days project of FOLFOX-4 was used in neoadjuvant chemotherapy(NCT). Every 2 weeks were repeated in one time. One chemotherapeutic cycle was 28 days. The surgical treatment was performed when 2 cycles of chemotherapy and evaluation of clinical effect were finished. The changes of bcl-2?bax protein expression and apoptosis index were observed by immunohistochemical citrate-microwave-SP and TUNEL technique. Results The positive cellular rates of bcl-2, bax and apoptosis index of rectal cancer tissues were 65.7%\u00b18.53%, 54.8%\u00b17.86%, 5.38%\u00b12.24% and 43.29%\u00b17.42%, 72.9%\u00b19.18%,10.79%\u00b13.05% respectively before and after neoadjuvant chemotherapy (NCT). It had significant statistical differences between the beginning and the end of NCT (P<0.01). Conclusions NCT may promote apoptosis of rectal cancer cells. expression level of bcl-2?bax gene have significantly correlated with curative effect of NCT. Furthermore the mentioned above 2 kinds of gene expression level would be come predictive index in curative effect of chemotherapy for patients with advanced rectal cancer.",
        "keywords": [
            "Rectal carcinoma",
            "Neoadjuvant chemotherapy",
            "Cellular apoptosis"
        ],
        "authors": [
            {
                "name": "WANG Hui",
                "org": " Department of Gastrointestinal Surgery, The First Municipal People's Hospital of Guangzhou, Guangzhou "
            },
            {
                "name": "CAO Jie",
                "org": " Department of Gastrointestinal Surgery, The First Municipal People's Hospital of Guangzhou, Guangzhou "
            },
            {
                "name": "YANG Ping",
                "org": " Department of Gastrointestinal Surgery, The First Municipal People's Hospital of Guangzhou, Guangzhou "
            },
            {
                "name": "ZHANG Wei-jian",
                "org": " Department of Gastrointestinal Surgery, The First Municipal People's Hospital of Guangzhou, Guangzhou "
            },
            {
                "name": "LI Wanglin",
                "org": " Department of Gastrointestinal Surgery, The First Municipal People's Hospital of Guangzhou, Guangzhou "
            },
            {
                "name": "TAN Minghua",
                "org": " Department of Gastrointestinal Surgery, The First Municipal People's Hospital of Guangzhou, Guangzhou "
            }
        ],
        "venue": "Lingnan Modern Clinics in Surgery",
        "year": 2007
    },
    "1SNEq4NQ": {
        "id": "1SNEq4NQ",
        "title": "Expression of KLF-6 protein in colorectal cancer and its correlation with serum CEA",
        "abstract": "Objective To study the expression of KLF6 protein in colorectal cancer(CRC) and its correlation with serum CEA level. Methods The expression of KLF6 protein in colorectal cancer,colorectal adenoma,and normal colorectal tissues was detected by immunohistochemistry.Serum CEA level in patients with colorectal cancer was measured by ELISA. Results The expression of KLF6 protein in normal colorectal tissues,colorectal adenoma and colorectal cancer were 85.7%,76.5% and 43.6%,respectively,with significant differences among them(X2=25.20,P<0.01).KLF6 expression was significantly correlated with differentiation grade,lymph node metastasis and TNM stage(P<0.05).However,no significant correlation between KLF6 expression and CEA was found(P>0.05). Conclusion Reducd expression of KLF6 in CRC suggests its inhibition on the oncogenesis of colorectal cancer.KLF6 is a useful marker for cancer risk evaluation of colorectal cancer.",
        "keywords": [
            "kruppel-like factor 6",
            "carcinoembryonic antigen",
            "colorectal cancer"
        ],
        "authors": [
            {
                "name": "WANG Qiang",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou First Municipal People\u2032s Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "CAO Jie",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou First Municipal People\u2032s Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "YANG Ping",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou First Municipal People\u2032s Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "SUN Zheng",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou First Municipal People\u2032s Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "ZHONG Jun-bin",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou First Municipal People\u2032s Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "LI Wang-lin",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou First Municipal People\u2032s Hospital,Guangzhou Medical College,Guangzhou ,China"
            }
        ],
        "venue": "Guangdong Medical Journal",
        "year": 2011
    },
    "xz5rrdsm": {
        "id": "xz5rrdsm",
        "title": "Effects of FHIT Gene Transfection on Proliferation and Invasion of Human Colon Cancer Cell Line SW480",
        "abstract": "Objective To investigate the effects of FHIT gene transfection on proliferation and invasion of human colon cancer cell line sw480.Methods Eukaryotic expression plasmid containing FHIT,pRc/CMV2-FHIT,was introduced into E.coli DH5\u03b1 and amplified.The plasmid was purified and identified by restrictive enzyme digestion.Plasmid pRc/CMV2-FHIT was transfected into SW480 cells,and positive cell clones(SW480-FHIT)were selected and amplified.plasmid-transfected SW480 cells(SW480-pRc/CMV2)and normal SW480 cells were set as control.Reverse transcription-polymerase chain reaction(RT-PCR)was applied to assess the expression of FHIT.Proliferation and invasion ability of SW480 cells were measured before and after transfection by MTT assay and cell invasion assay,respectively.Results SW480 cell transfected with pRc/CWV2-FHIT was approve to express FHIT,while FHIT expression was completely absent in the control group.The expression of FHIT significantly inhibited the proliferation and the invasion of SW480 cells in the experimental group(P<0.01).Conclusion Re-expression of FHIT gene using gene transfection technology effectively inhibits the growth and proliferation of SW480 cell,and induces apoptosis of SW480 cell.The pRc/CMV2-FHIT rovides novel therapeutic potentials for the treatment of human colon carcinoma.",
        "keywords": [
            "gene transfection",
            "colon carcinoma",
            "fragile histidine triad"
        ],
        "authors": [
            {
                "name": "QIAN Yue-jun",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou first municipal people's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "CAO Jie",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou first municipal people's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "YANG Ping",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou first municipal people's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "WANG Hui",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou first municipal people's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "SUN Zheng",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou first municipal people's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "CHEN Xi-wen",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou first municipal people's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "WANG Qiang",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou first municipal people's Hospital,Guangzhou Medical College,Guangzhou ,China"
            }
        ],
        "venue": "Guangdong Medical Journal",
        "year": 2010
    },
    "hIvWvsdV": {
        "id": "hIvWvsdV",
        "title": "Trichinella spiralis infection alters mouse colonic epithelial permeability",
        "abstract": "AIM: To study the effect of Trichinella spiralis(T.spiralis) infection on colonic epithelial permeability in mice.METHODS: T.spiralis was applied to infect BALB/c mice.Seven days after infection,horseradish peroxidase(HRP) was infused into the rectum of the mice infected with T.spiralis.Serum HRP was detected in the subsequent 0 min,60 min and 120 min.The expression of interleukin-4(IL-4) in mesenteric lymph nodes was detected by ELISA.Additionally,T.spiralis was also applied to infect STAT6 knockout mice,and the above indexes were also determined.RESULTS: In BALB/c mice,T.spiralis infection significantly increased colonic permeability.IL-4 and IgG1 was significantly higher,IgG2a was significantly lower(all P<0.05) after infection.However,in STAT6 knockout mice,T.spiralis infection did not change colonic permeability(P>0.05).Compared with BALB/c infection group,IL-4 level in STAT6 knockout infection group was significantly lower(P<0.05).CONCLUSION: T.spiralis infection induces an increase in mouse colonic epithelial permeability by promoting the secretion of IL-4.",
        "keywords": [
            "Trichinella spiralis",
            "Interleukin-4",
            "Colonic epithelium"
        ],
        "authors": [
            {
                "name": "LI Wang-lin",
                "org": "Department of Gastrointestinal Surgery,Guangzhou First Municipal People's Hospital Affiliated to Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "CAO Jie",
                "org": "Department of Gastrointestinal Surgery,Guangzhou First Municipal People's Hospital Affiliated to Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "ZHANG Wei-jian",
                "org": "Department of Gastrointestinal Surgery,Guangzhou First Municipal People's Hospital Affiliated to Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Gastrointestinal Surgery,Guangzhou First Municipal People's Hospital Affiliated to Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "ZHONG Jun-bin",
                "org": "Department of Gastrointestinal Surgery,Guangzhou First Municipal People's Hospital Affiliated to Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "YANG Jian-rong",
                "org": "Department of Gastrointestinal Surgery,Guangzhou First Municipal People's Hospital Affiliated to Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "ZHANG Tong",
                "org": "Department of Gastrointestinal Surgery,Guangzhou First Municipal People's Hospital Affiliated to Guangzhou Medical College,Guangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Pathophysiology",
        "year": 2012
    },
    "x86wo9wr": {
        "id": "x86wo9wr",
        "title": "Therapeutic analysis of PPH in 120 cases with severe hemorrhoids",
        "abstract": "Objective To explore the operative skill and applied value for double-perse-suture PPH. Methods 120 cases with severe hemorrhoids(\u2162\u00b0 or \u2163\u00b0) were divided into double-perse-suture PPH group and one-perse-suture PPH group randomly.There were 60 cases in each group. The operative time,postoperative pain,postoperative complications and recurrence were observed in two groups. Results The operative time,postoperative pain didn't show significant difference(P > 0.05) between two groups. In the postoperative complication rate and recurrence rate,the double-perse-suture PPH group was lower than that one-perse-suture PPH group(P < 0.05=. Conclusion Because of double-perse-suture PPH has less postoperative complications and lower recurrence rate,so double-perse-suture PPH is much superior to the one-perse-suture PPH in the treatment of severe hemorrhoids.",
        "keywords": [
            "Procedure for prolapse and hemorrhoids",
            "Stapler",
            "Hemorrhoid"
        ],
        "authors": [
            {
                "name": "CAO Jie",
                "org": ",CHEN Xin qi Department of Gastrointestinal Surgery, The Affiliated First Municipal People's Hospital, Guangzhou Medical College, Guangzhou "
            },
            {
                "name": "WANG Hui",
                "org": ",CHEN Xin qi Department of Gastrointestinal Surgery, The Affiliated First Municipal People's Hospital, Guangzhou Medical College, Guangzhou "
            },
            {
                "name": "YANG Ping",
                "org": ",CHEN Xin qi Department of Gastrointestinal Surgery, The Affiliated First Municipal People's Hospital, Guangzhou Medical College, Guangzhou "
            },
            {
                "name": "CHEN Wei",
                "org": ",CHEN Xin qi Department of Gastrointestinal Surgery, The Affiliated First Municipal People's Hospital, Guangzhou Medical College, Guangzhou "
            }
        ],
        "venue": "Lingnan Modern Clinics in Surgery",
        "year": 2008
    },
    "9NgQsxmS": {
        "id": "9NgQsxmS",
        "title": "Expressions and clinical significance of Survivin mRNA and BCL-2\u3001VEGF in colorectal cancer",
        "abstract": "Objective To investigate the different expression and significance of Survivin mRNA and Bcl-2\u3001VEGF protein in colorectal carcinoma with tissue microarray technology. Methods Colorectal carcinoma tissue microarray technology were established to detect Survivin mRNA and Bcl-2\u3001VEGF protein expression in 80 cases of colorectal carcinoma\u300116 cases colorectal adenoma and 16 case of Haemorrhoids (PPH) in the same period of time as the control. Survivin mRNA was detected through situ hybridization. The expressions of bcl-2 and VEGF were determined immunohistochemically, and TLNEL techniques were used to detect apoptosis. The relationship to clinicopathological factors such as differentiation grades and pathological stages were observed. Results The expressions of survivin mRNA and bcl-2\u3001VEGF protein were higher significantly in colorectal carcinomas than in adenoma and normal colorectal tissues(P<0.01). It were showed that the increase of survivin mRNA expression were not associated with age, sex and serum CEA levels of the patients and sites, sizes, histological classification, Clinicopathological analysis of patients but were associated with differentiation grades, pathological stages and lymph nodes metastases. A positive correlation was observed between survivin mRNA and bcl-2?VEGF proteinapoptosis (P<0.01). The average survival time of patients with higher expression of survivin mRNA were 31.6 months, and that of patients with lower expression of survivin mRNA were 45.2months. 5-year survival rate of the former (65.2%,30/46)were significantly lower than that of the latter (88.9%,40/45)(P<0.05). Conclusion The overexpression of Survivin mRNA and Bcl-2VEGF protein in colorectal carcinomas play an important role in the pathogenesis, development, infiltration, and metastases of the tumor. Determination of Survivin and bcl-2VEGF expression would be helpful for the.",
        "keywords": [
            "Survivin",
            "bcl-2",
            "In situ hybridization",
            "Colorectal carcinoma",
            "Vascular epithelial growth factor"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": " Department of Gastrointestinal Surgery, The First Affiliated People's Hospital, Guangzhou Medical College,Guangzhou "
            },
            {
                "name": "CAO Jie",
                "org": " Department of Gastrointestinal Surgery, The First Affiliated People's Hospital, Guangzhou Medical College,Guangzhou "
            },
            {
                "name": "WANG Hui",
                "org": " Department of Gastrointestinal Surgery, The First Affiliated People's Hospital, Guangzhou Medical College,Guangzhou "
            },
            {
                "name": "LI Wanglin",
                "org": " Department of Gastrointestinal Surgery, The First Affiliated People's Hospital, Guangzhou Medical College,Guangzhou "
            },
            {
                "name": "TAN Minghua",
                "org": " Department of Gastrointestinal Surgery, The First Affiliated People's Hospital, Guangzhou Medical College,Guangzhou "
            }
        ],
        "venue": "Lingnan Modern Clinics in Surgery",
        "year": 2006
    },
    "3zXsx1Ya": {
        "id": "3zXsx1Ya",
        "title": "Expression of KLF6 protein on colorectal cancer and its relationship with apoptosis",
        "abstract": "Objective To investigate the expression of KLF6,Bax and Bcl-2,their role in Sporadic Colorectal Cancer(CRC) and the possible correlation between KLF6 protein and apoptosis.Methods Expression of protein in Colorectal cancer was examined by immunohistochemistry methods.Apoptosis in colorectal cancer was examined by TUNEL technique.The result of the examination was statistically analyzed.Results Positivity of KLF6 was detected in 82.6% of the mucosa of adjacent cancer,in 75.0% of adenomas and in 52.7% of cancer specimens.There was significant difference in the mucosa of adjacent cancer,colorectal adenomas and colorectal cancer (P<0.05).The positive rate was 61.8% in Bax protein expression of colorectal cancer,43.6% in Bcl-2 protein expression of colorectal cancer.There were significant differences between KLF6 expression and lymph node metastasis,TNM stage and 3-year survival rate.KLF6 expression was significantly correlated with Bcl-2 and Bax expression in colorectal cancer.The Apoptosis Indexes (AI) was statistically related to the expression grade of KLF6 protein.Conclusions In this study,we found that KLF6 protein reduced and played an important role in the development of SCRC.Gene KLF6 may be an anti-oncogene and may be associated with CRC cell apoptosis.",
        "keywords": [
            "Bax",
            "KLF6",
            "Apoptosis",
            "Bcl-2",
            "Colorectal neoplasm"
        ],
        "authors": [
            {
                "name": "LIANG Li-yuan",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou first municipal people's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "CAO Jie",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou first municipal people's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "WANG Qiang",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou first municipal people's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "YANG Ping",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou first municipal people's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "SUN Zheng",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou first municipal people's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "XIAO Huan-qing",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou first municipal people's Hospital,Guangzhou Medical College,Guangzhou ,China"
            },
            {
                "name": "LIU Zhen-bang",
                "org": ".Department of Gastrointestinal Surgery,Affiliated Guangzhou first municipal people's Hospital,Guangzhou Medical College,Guangzhou ,China"
            }
        ],
        "venue": "The Journal of Practical Medicine",
        "year": 2011
    },
    "dHj4b8he": {
        "id": "dHj4b8he",
        "title": "Inhibition of AP-4 gene expression by zinc phthalocyanine-mediated photodynamic therapy in human colon cancer cell line SW480",
        "abstract": "Objective To investigate the influence of zinc phthalocyanine on the proliferation and AP-4 gene expression in SW480 cells in vitro.Methods The cell proliferation was analyzed by cell counting kit-8(CCK8) assay,while the AP-4 mRNA and protein expression after photodynamic therapy(PDT) were analyzed by RT-PCR and Western blot,respectively.Meanwhile,the flow cytometry(FCM) was used to detect the cell apoptosis and cycle.Results The proliferation of SW480 cells was significantly suppressed by zinc phthalocyanine-mediated PDT in concentration-and light dose-dependent manners.The cell was arrested at G2/M by PDT,while the apoptosis rate was enhanced with zinc phthalocyanine in concentration dependent manner.After 2.0 \u03bcg/mL zinc phthalocyanine-mediated PDT,the AP-4 mRNA and protein were significantly reduced by 81% and 75.6%,respectively,in SW480 cells(P<0.01).Conclusion Zinc phthalocyanine-mediated PDT can effectively suppress the expression of AP-4,and inhibit the cell growth and proliferation,and induce apoptosis in SW480 cells,suggesting novel treatment of human colon cancer.",
        "keywords": [
            "photodynamic therapy",
            "AP-4",
            "zinc phthalocyanine",
            "colon carcinoma"
        ],
        "authors": [
            {
                "name": "ZHANG Tong",
                "org": ".Department of Gastrointestinal Surgery,Guangzhou First People\u2032s Hospital,Guangzhou ,China"
            },
            {
                "name": "CAO Jie",
                "org": ".Department of Gastrointestinal Surgery,Guangzhou First People\u2032s Hospital,Guangzhou ,China"
            },
            {
                "name": "YANG Ping",
                "org": ".Department of Gastrointestinal Surgery,Guangzhou First People\u2032s Hospital,Guangzhou ,China"
            },
            {
                "name": "LI Wang-lin",
                "org": ".Department of Gastrointestinal Surgery,Guangzhou First People\u2032s Hospital,Guangzhou ,China"
            },
            {
                "name": "SUN Zheng",
                "org": ".Department of Gastrointestinal Surgery,Guangzhou First People\u2032s Hospital,Guangzhou ,China"
            },
            {
                "name": "ZHANG Wei-jian",
                "org": ".Department of Gastrointestinal Surgery,Guangzhou First People\u2032s Hospital,Guangzhou ,China"
            },
            {
                "name": "ZENG Shan-qi",
                "org": ".Department of Gastrointestinal Surgery,Guangzhou First People\u2032s Hospital,Guangzhou ,China"
            }
        ],
        "venue": "Guangdong Medical Journal",
        "year": 2013
    },
    "8kHwIvh9": {
        "id": "8kHwIvh9",
        "title": "Expression of EZH2 is associated with poor outcome in colorectal cancer.",
        "abstract": "Enhancer of zeste homolog 2 (EZH2), the critical component of polycomb group protein family, has been demonstrated to be overexpressed in various types of human cancer, including hepatocellular carcinoma, breast, bladder and lung cancer. The mechanism of how EZH2 promotes oncogenesis has also been well studied. However, little is known about the role of EZH2 in colorectal cancer (CRC). The main purpose of the present study was to analyze the association between EZH2 expression and the clinicopathological features of CRC. Therefore, the mRNA and protein expression levels were analyzed in tumor tissues and adjacent non-cancerous tissues by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis. The expression of EZH2 was demonstrated to be significantly increased in tumor tissues compared with adjacent noncancerous tissues, according to the results of western blot analysis and RT-qPCR in the majority of cases. Patients with low EZH2 expression had a longer overall survival rate compared with those with high EZH2 expression. An analysis of the association between clinicopathological features and EZH2 expression indicated that high EZH2 expression was significantly associated with tumor stage, tumor size, histological differentiation and lymph node metastasis. Multivariate analysis demonstrated that high EZH2 expression was an independent predictor of overall survival. In conclusion, to the best of our knowledge, the data presented in the present study is the first to indicate that EZH2 is upregulated in CRC and may serve as a predictor of poor outcome for patients with CRC.",
        "keywords": [
            "clustered regularly interspaced short palindromic repeats",
            "colorectal cancer",
            "enhancer of zeste homolog",
            "polycomb group protein",
            "prognosis"
        ],
        "authors": [
            {
                "name": "Zhuanpeng Chen",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Ping Yang",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Wanglin Li",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Feng He",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Jianchang Wei",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Tong Zhang",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Junbin Zhong",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Huacui Chen",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Jie Cao",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            }
        ],
        "venue": "Oncology letters",
        "year": 2018
    },
    "AObCFCtX": {
        "id": "AObCFCtX",
        "title": "Overexpression of flavin-containing monooxygenase 5 predicts poor prognosis in patients with colorectal cancer.",
        "abstract": "The present study investigated the expression and clinical significance of flavin-containing monooxygenase 5 (FMO5) in colorectal cancer (CRC). The expression of FMO5 was detected by immunohistochemistry in 208 colon cancer tissues and 8 normal colon tissues. Then, the correlations of FMO5 expression with several clinicopathological features were evaluated. FMO5 mRNA expression from The Cancer Genome Atlas dataset was assessed for further validation. In addition, the association of the expression of FMO5 with prognosis was further evaluated by Kaplan-Meier survival curves and Cox proportional hazards model. The FMO5 protein level in colon cancer tissues was significantly higher than that in normal colon tissues (P<0.001). Overexpression of FMO5 was associated with an advanced clinical stage of cancer (P=0.018) and lymph node metastasis (P=0.03). The TCGA dataset also demonstrated that FMO5 was upregulated in CRC with advanced clinical stage (P=0.047), lymph node metastasis (P=0.045) and distant metastasis (P=0.030). The Kaplan-Meier survival curves showed that higher FMO5 mRNA indicated a shorter overall survival in patients with CRC compared with a low expression of FMO5 (P=0.029). Cox proportional hazards regression revealed that a high FMO5 mRNA level served as an independent prognostic factor for patients with CRC (hazard ratio, 2.865; 95% confidence interval, 1.116-7.355; P=0.029). A high expression of FMO5 may serve roles in colorectal carcinogenesis and distant metastasis. FMO5 may be an independent predictive factor for the prognosis of CRC.",
        "keywords": [
            "colorectal cancer",
            "flavin-containing monooxygenase 5",
            "prognosis"
        ],
        "authors": [
            {
                "name": "Tong Zhang",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Ping Yang",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Jianchang Wei",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Wanglin Li",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Junbin Zhong",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Huacui Chen",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Jie Cao",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            }
        ],
        "venue": "Oncology letters",
        "year": 2018
    },
    "yIpmKK21": {
        "id": "yIpmKK21",
        "title": "Gankyrin sustains PI3K/GSK-3\u03b2/\u03b2-catenin signal activation and promotes colorectal cancer aggressiveness and progression.",
        "abstract": "High levels of angiogenesis, metastasis and chemoresistance are major clinical features of colorectal cancer (CRC), a lethal disease with a high incidence worldwide. Aberrant activation of Wnt/\u03b2-catenin pathway contributes to CRC progression. However, little is known about regulatory mechanisms of the \u03b2-catenin activity in cancer progression. Here we report that Gankyrin was markedly upregulated in primary tumor tissues from CRC patients and was associated with poor survival. Moreover, we demonstrated that overexpressing Gankyrin promoted, while knockdown of Gankyrin impaired, the aggressive phenotype of proliferation, angiogenesis, chemoresistance and metastasis of CRC cells both in vitro and in vivo. Importantly, we found a unique molecular mechanism of Gankyrin in CRC cells signaling transduction, that regulated the cross-talk between PI3K/Akt and Wnt/\u03b2-catenin signaling pathways, sustaining PI3K/GSK-3\u03b2/\u03b2-catenin signal activation in CRC. Therefore, these findings not only reveal a mechanism that promotes aggressiveness and progression in CRC, but also provide insight into novel molecular targets for antitumor therapy in CRCs.",
        "keywords": [
            "PI3K/Akt signaling",
            "Wnt/\u03b2-catenin signaling",
            "colorectal cancer",
            "gankyrin",
            "metastasis"
        ],
        "authors": [
            {
                "name": "Feng He",
                "org": "Department of Pathology, Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, Connecticut 06520, USA."
            },
            {
                "name": "Huacui Chen",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China."
            },
            {
                "name": "Ping Yang",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China."
            },
            {
                "name": "Qianlong Wu",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China."
            },
            {
                "name": "Tong Zhang",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China."
            },
            {
                "name": "Chengxing Wang",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China."
            },
            {
                "name": "Jianchang Wei",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China."
            },
            {
                "name": "Zhuanpeng Chen",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China."
            },
            {
                "name": "He Hu",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China."
            },
            {
                "name": "Wanglin Li",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China."
            },
            {
                "name": "Jie Cao",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China."
            }
        ],
        "venue": "Oncotarget",
        "year": 2016
    },
    "cWQ68Yfp": {
        "id": "cWQ68Yfp",
        "title": "Long noncoding RNA PVT1-214 promotes proliferation and invasion of colorectal cancer by stabilizing Lin28 and interacting with miR-128.",
        "abstract": "Long noncoding RNAs (lncRNAs) are implicated in human cancer, but their mechanisms of action are largely unknown. In this study, we investigated lncRNA alterations that contribute to colorectal cancer (CRC) through microarray expression profiling in CRC patient samples. Here, we report that the CRC-associated lncRNA PVT1-214 is a key regulator of CRC development and progression; patients with high PVT1-214 expression had a shorter survival and poorer prognosis. In vitro and in vivo investigation of the role of PVT1-214 revealed a complex integrated phenotype affecting cell growth, stem-like properties, migration, and invasion. Furthermore, using RNA pull-down and mass spectrometry, we found that Lin28 (also known as Lin28A), a highly conserved RNA-binding protein, is associated with PVT1-214. Strikingly, we found that PVT1-214 not only upregulated Lin28 protein expression in CRC cells by stabilizing Lin28, but also participated in crosstalk with Lin28 mRNA through competition for miR-128 binding, imposing an additional level of post-transcriptional regulation. In addition, we further show that PVT1-214 repressed expression of let-7 family miRNAs, which was abrogated by Lin28 knockdown. Taken together, our findings support a model in which the PVT1-214/Lin28/let-7 axis serves as a critical regulator of CRC pathogenesis, which may simulate a new direction for CRC therapeutic development.",
        "keywords": "",
        "authors": [
            {
                "name": "Feng He",
                "org": "Department of Pathology, Yale University School of Medicine, New Haven, 06520, CT, USA."
            },
            {
                "name": "Zhi Song",
                "org": "Department of Operative Dentistry and Endodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University and Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, 510055, China."
            },
            {
                "name": "Huacui Chen",
                "org": "Department of General Surgery, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, 510180, China."
            },
            {
                "name": "Zhuanpeng Chen",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, 510180, China."
            },
            {
                "name": "Ping Yang",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, 510180, China."
            },
            {
                "name": "Wanglin Li",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, 510180, China."
            },
            {
                "name": "Zhi Yang",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, 510180, China."
            },
            {
                "name": "Tong Zhang",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, 510180, China."
            },
            {
                "name": "Fei Wang",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, 510180, China."
            },
            {
                "name": "Jianchang Wei",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, 510180, China."
            },
            {
                "name": "Fang Wei",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, 510180, China."
            },
            {
                "name": "Qiang Wang",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, 510180, China."
            },
            {
                "name": "Jie Cao",
                "org": "Department of General Surgery, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, 510180, China. czhongt@126.com."
            }
        ],
        "venue": "Oncogene",
        "year": 2018
    },
    "Jr3MFgqm": {
        "id": "Jr3MFgqm",
        "title": "Overexpression of transcription factor activating enhancer binding protein 4 (TFAP4) predicts poor prognosis for colorectal cancer patients.",
        "abstract": "Transcription factor activating enhancer binding protein 4 (TFAP4) is an important regulator in the genesis and progression of human cancers. Overexpression of TFAP4 has been found to be correlated with several malignancies. The present study assessed the clinical importance of TFAP4 in colorectal cancer (CRC). First, immunohistochemistry was used to analyze TFAP4 expression and the association of TFAP4 expression with clinicopathological features on a tissue microarray containing 208 CRC patients. The results revealed that TFAP4 protein expression was significantly upregulated in CRC tissues compared with that in normal colon tissues (P<0.001). Of note, statistical analysis revealed that TFAP4 expression was significantly correlated with a high pathological grade (P=0.034), advanced clinical stage (P=0.024), enhanced tumor invasion (P=0.002) and lymph node metastasis (P=0.041). In addition, the Cancer Genome Atlas dataset further validated that TFAP4 mRNA levels were increased in CRC with advanced clinical stage (P=0.026), lymph node metastasis (P=0.018) and vascular invasion (P=0.046). Kaplan-Meier survival analysis demonstrated that CRC patients with high TFAP4 expression had shorter overall survival compared with those with low TFAP4 expression (P=0.011). Importantly, overexpression of TFAP4 was a valuable independent prognostic factor for CRC patients (hazard ratio, 8.200; 95% confidence interval, 1.838-36.591; P=0.006). In summary, TFAP4 may have an important role in CRC progression and upregulation of TFAP4 may be a predictor of poor prognosis for CRC patients.",
        "keywords": [
            "colorectal cancer",
            "prognosis",
            "transcription factor activating enhancer binding protein 4"
        ],
        "authors": [
            {
                "name": "Jianchang Wei",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Ping Yang",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Tong Zhang",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Zhuanpeng Chen",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Wei Chen",
                "org": "Department of Pancreatobiliary Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Li Wanglin",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Feng He",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Fang Wei",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Di Huang",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Junbin Zhong",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Zhi Yang",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Huacui Chen",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "He Hu",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Shanqi Zeng",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Zheng Sun",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            },
            {
                "name": "Jie Cao",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China."
            }
        ],
        "venue": "Experimental and therapeutic medicine",
        "year": 2017
    },
    "tD8i1QDR": {
        "id": "tD8i1QDR",
        "title": "Long non\u2011coding RNA 00152 functions as a competing endogenous RNA to regulate NRP1 expression by sponging with miRNA\u2011206 in colorectal cancer.",
        "abstract": "Colorectal cancer (CRC) is the third most common type of cancer; however, the molecular mechanisms underlying colorectal tumor metastasis and growth remain elusive. Recently, accumulating evidence has indicated that long non\u2011coding RNAs (lncRNAs) play a critical role in CRC progression and metastasis; however, the biological role and clinical significance of lncRNA 00152 (lnc00152) in CRC remains largely unknown. Thus, in this study, lnc00152 expression was measured in 80\u00a0human CRC tissue samples, 40\u00a0non\u2011cancerous tissue samples, and 3\u00a0CRC cell lines (SW480, SW620 and LoVo) using RT\u2011qPCR. We examined the effects of lnc00152 on CRC cells following transfection with lnc00152 overexpression plasmid or respective siRNA in\u00a0vitro and in\u00a0vivo. Luciferase assays revealed the mechanism driving competitive endogenous RNA (ceRNA). We identified that lnc00152 was aberrantly overexpressed in colorectal tumors and cancer cells and that lnc00152 was modulated by miRNA\u2011206. lnc00152 overexpression enhanced the proliferative and invasive ability of CRC cells in\u00a0vitro, promoted tumor growth in\u00a0vivo, and was associated with the shorter overall survival of patients with CRC. In addition, lnc00152 overexpression promoted epithelial-mesenchymal transition\u00a0(EMT) and increased neuropilin\u20111 (NRP1) expression in the CRC cells. By contrast, lnc00152 silencing exerted a counteractive effect. Collectively, these findings demonstrate the critical role of lnc00152 in tumor growth and progression in CRC, and identify a novel therapeutic target associated with CRC development and progression.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhuan-Peng Chen",
                "org": "Department of Gastrointestinal Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou Guangdong 510180, P.R. China."
            },
            {
                "name": "Jian-Chang Wei",
                "org": "Department of Gastrointestinal Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou Guangdong 510180, P.R. China."
            },
            {
                "name": "Qiang Wang",
                "org": "Department of Gastrointestinal Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou Guangdong 510180, P.R. China."
            },
            {
                "name": "Ping Yang",
                "org": "Department of Gastrointestinal Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou Guangdong 510180, P.R. China."
            },
            {
                "name": "Wang-Lin Li",
                "org": "Department of Gastrointestinal Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou Guangdong 510180, P.R. China."
            },
            {
                "name": "Feng He",
                "org": "Department of Gastrointestinal Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou Guangdong 510180, P.R. China."
            },
            {
                "name": "Hua-Cui Chen",
                "org": "Department of Gastrointestinal Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou Guangdong 510180, P.R. China."
            },
            {
                "name": "He Hu",
                "org": "Department of Gastrointestinal Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou Guangdong 510180, P.R. China."
            },
            {
                "name": "Jun-Bin Zhong",
                "org": "Department of Gastrointestinal Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou Guangdong 510180, P.R. China."
            },
            {
                "name": "Jie Cao",
                "org": "Department of Gastrointestinal Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou Guangdong 510180, P.R. China."
            }
        ],
        "venue": "International journal of oncology",
        "year": 2018
    },
    "fV59X7u9": {
        "id": "fV59X7u9",
        "title": "Establishment of multiple diagnosis models for colorectal cancer with artificial neural networks.",
        "abstract": "The current study aimed to develop multiple diagnosis models for colorectal cancer (CRC) based on data from The Cancer Genome Atlas database and analysis with artificial neural networks in order to enhance CRC diagnosis methods. A genetic algorithm and mean impact value were used to select genes to be used as numerical encoded parameters to reflect cancer metastasis or aggression. Back propagation and learning vector quantization neural networks were used to build four diagnosis models: Cancer/Normal, M0/M1, carcinoembryonic antigen (CEA) <5/\u22655 and Clinical stage I-II/III-IV. The performance of each model was evaluated by predictive accuracy (ACC), the area under the receiver operating characteristic curve (AUC) and a 10-fold cross-validation test. The ACC and AUC of the Cancer/Normal, M0/M1, CEA and Clinical stage models were 100%, 1.000; 87.14%, 0.670; 100%, 1.000; and 100%, 1.000, respectively. The 10-fold cross-validation test of the ACC values and sensitivity for each test were 93.75-99.39%, 1.0000; 80.58-88.24%, 0.9286-1.0000; 67.21-92.31%, 0.7091-1.0000; and 59.13-68.85%, 0.6017-0.6585, respectively. The diagnosis models developed in the current study combined gene expression profiling data and artificial intelligence algorithms to create tools for improved diagnosis of CRC.",
        "keywords": [
            "artificial neural networks",
            "colorectal cancer",
            "diagnosis model"
        ],
        "authors": [
            {
                "name": "Qiang Wang",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Centre, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong 510000, P.R. China."
            },
            {
                "name": "Jianchang Wei",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Centre, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong 510000, P.R. China."
            },
            {
                "name": "Zhuanpeng Chen",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Centre, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong 510000, P.R. China."
            },
            {
                "name": "Tong Zhang",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Centre, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong 510000, P.R. China."
            },
            {
                "name": "Junbin Zhong",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Centre, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong 510000, P.R. China."
            },
            {
                "name": "Bingzheng Zhong",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Centre, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong 510000, P.R. China."
            },
            {
                "name": "Ping Yang",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Centre, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong 510000, P.R. China."
            },
            {
                "name": "Wanglin Li",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Centre, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong 510000, P.R. China."
            },
            {
                "name": "Jie Cao",
                "org": "Department of General Surgery, Guangzhou Digestive Disease Centre, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong 510000, P.R. China."
            }
        ],
        "venue": "Oncology letters",
        "year": 2019
    },
    "okhLxsxh": {
        "id": "okhLxsxh",
        "title": "Phase aberration correction in poor SNR environment for ultrasonic phased array",
        "abstract": "Phase aberration correction can cancel phase aberration in ultrasonic phased array.In practice,some arrays suffer from small element,weak signal and poor signal-to-noise ratio.The correction abilities of the neighboring and sum-up correlations were studied with various background noise amplitudes.Errors created by the neighboring correlation estimates are almost zero for SNR above 12 dB,but the errors increase dramatically for SNR below 5 dB.The error created by the sum-up correlation estimate is not zero even if the SNR is very high but the error does not increase significantly as the SNR decreases.A combined correction architecture was then developed for phased array that provides better even correction than other architectures.",
        "keywords": [
            "Aberration correction",
            "Cross-correlation",
            "Non-destructive testing",
            "Signal-to-noise ratio (SNR)",
            "Ultrasonic phased array"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Non-Destructive Testing Center,Department of Mechanical Engineering,Tsinghua University,Beijing ,China"
            },
            {
                "name": "CHEN Bin",
                "org": "Non-Destructive Testing Center,Department of Mechanical Engineering,Tsinghua University,Beijing ,China"
            },
            {
                "name": "Keren Shi",
                "org": "Tsinghua University(Tsinghua University,Tsinghua Univ,Tsinghua Univ.),Beijing,China"
            }
        ],
        "venue": "Journal of Tsinghua University(Science and Technology)",
        "year": 2006
    },
    "7NDIPKY6": {
        "id": "7NDIPKY6",
        "title": "Application of Hilbert-Huang transforms for nonlinear ultrasonic nondestructive testing",
        "abstract": "The Hilbert-Huang transform was used to improve estimates of the position and relative size of defects for nonlinear ultrasonic nondestructive testing.The detected signal in stainless steel is nonlinear,non-stationary and has a low signal-to-noise ratio.The instantaneous frequency can indicate the defect position,which the instantaneous amplitude can characterize the relative defect size.The method can detect a \ue07e 0.8 mm flat-bottom hole(at a depth of 65 mm) in a stainless steel sample of average grain size(0.6 mm).Therefore,the Hilbert-Huang transform provides an improved ability to detect defects through time-resolved testing.",
        "keywords": [
            "nonlinear ultrasound",
            "coarse grain materials",
            "nondestructive testing",
            "Hilbert-Huang transform"
        ],
        "authors": [
            {
                "name": "CHEN Bin",
                "org": "Department of Mechanical Engineering,Tsinghua University,Beijing ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Mechanical Engineering,Tsinghua University,Beijing ,China"
            },
            {
                "name": "SHI Keren",
                "org": "Department of Mechanical Engineering,Tsinghua University,Beijing ,China"
            }
        ],
        "venue": "Journal of Tsinghua University(Science and Technology)",
        "year": 2006
    },
    "8rCfdl38": {
        "id": "8rCfdl38",
        "title": "Optimal design of random sparse 2-D arrays based on genetic algorithm",
        "abstract": "In order to limit complexity of the 2-D phased array and its 3-D ultrasound imaging system, a optimal design method of random sparse 2-D arrays based on genetic algorithm is developed. Firstly, the aperture size and the element weights of the array reference is pre-determined according to spatial resolution. Secondly, the sparse ratio is determined according to contrast resolution and the sparse array is designed by randomly removing a fraction of the original set of elements from the 2-D array reference. Consequently, the distribution of the reserved element is optimized by the use of the genetic algorithm to achieve acceptable acoustic properties. The acoustic characteristic of the sparse arrays is analyzed through continuous wave theory and pulse ultrasound field model based on the spatial impulse response. Results show that sparse arrays based on genetic algorithm have a good overall performance. The main-lobe is practically unaffected by the random removal of elements, and grating lobes are avoided in these arrays, but the average side-lobe level increases a little. However, it can satisfy the needs for the high-quality ultrasound imaging when the sparse array is optimized using the genetic algorithm.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Jian Huo",
                "org": "Tsinghua University(Tsinghua University,Tsinghua Univ,Tsinghua Univ.),Beijing,China"
            },
            {
                "name": "Ping Yang",
                "org": "Tsinghua University(Tsinghua University,Tsinghua Univ,Tsinghua Univ.),Beijing,China"
            },
            {
                "name": "Keren Shi",
                "org": "Tsinghua University(Tsinghua University,Tsinghua Univ,Tsinghua Univ.),Beijing,China"
            },
            {
                "name": "Wei Zhang",
                "org": "Tsinghua University(Tsinghua University,Tsinghua Univ,Tsinghua Univ.),Beijing,China"
            }
        ],
        "venue": "Shengxue Xuebao/Acta Acustica",
        "year": 2006
    },
    "6EpjxENf": {
        "id": "6EpjxENf",
        "title": "A novel method to design 2D sparse array for ultrasonic phased array",
        "abstract": "Sparse array is an effective way to enlarge aperture and enhance spatial res- olution.The popular methods of designing sparse array can not supply the best array configuration.In this article,2D sparse arrays are designed firstly by Genetic algorithm. But sparse array designed only by Genetic algorithm have bad consistency probably because the searching space is too huge and parameters of Genetic algorithm can not be perfectly controlled.Borrow the idea from mill-cross sparse array and the MRLA- Minimum-Redundancy Linear Array,a new method is put forward to design the 2D sparse array.Both simulation and experiment confirm the effectiveness of this combined method.",
        "keywords": [
            "Genetic algorithm",
            "2D sparse array",
            "MRLA-Minimum-redundancy linear array",
            "Ultrasonic phased array"
        ],
        "authors": [
            {
                "name": "Yang Ping",
                "org": " Department of Mechanical Engineering,Tsinghua University,Beijing "
            },
            {
                "name": "Shi Ke-Ren",
                "org": " Department of Mechanical Engineering,Tsinghua University,Beijing "
            }
        ],
        "venue": "Applied Acoustics",
        "year": 2008
    },
    "9L5ywXPR": {
        "id": "9L5ywXPR",
        "title": "3-D imaging by a 2-D ultrasonic phased array",
        "abstract": "The main difficulties in implementing 3-D imaging by a 2-D array are the need for more elements and more channels, the system complexity and weak signals. In this article, the behavior of the time-space signal in a discrete long window is analyzed to identify rules to design the probe. A square 2-D array with 8 \u00d7 8 elements was designed using computer simulation for 3-D imaging. Tests show that the testing system and the 2-D array both perform well. The 3-D imaging supplies accurate information about the contour of a defect, which confirms its effectiveness for fast and accurate non-destructive testing and evaluation.",
        "keywords": [
            "Phased array",
            "Three dimensional imaging",
            "Two dimensional array",
            "Ultrasonic non-destructive testing"
        ],
        "authors": [
            {
                "name": "Keren Shi",
                "org": "Tsinghua University(Tsinghua University,Tsinghua Univ,Tsinghua Univ.),Beijing,China"
            },
            {
                "name": "Ping Yang",
                "org": "Tsinghua University(Tsinghua University,Tsinghua Univ,Tsinghua Univ.),Beijing,China"
            },
            {
                "name": "Bin Chen",
                "org": "Tsinghua University(Tsinghua University,Tsinghua Univ,Tsinghua Univ.),Beijing,China"
            }
        ],
        "venue": "Journal of Tsinghua University(Science and Technology)",
        "year": 2006
    },
    "ggaXWsW4": {
        "id": "ggaXWsW4",
        "title": "Space-Time Block Coded Rectangular Differential Spatial Modulation.",
        "abstract": "In this paper, a novel space-time block coded rectangular differential spatial modulation (STBC-RDSM) is proposed for multiple-input and multiple-out (MIMO) system, which combines the space-time block coding (STBC) and rectangular differential spatial modulation (RDSM) to take the advantages of RDSM and STBC systems, while avoiding the drawbacks of conventional differential spatial modulation (DSM) systems. More specifically, in the proposed STBC-RDSM scheme, the information bits are conveyed via the rectangular differential encoded antenna indices matrices, as well as the STBC blocks. Our simulation results demonstrate that STBC-RDSM outperforms the existing DSM systems for various spectral efficiencies.",
        "keywords": "",
        "authors": [
            {
                "name": "Chaowu Wu",
                "org": "University of Electronic Science and Technology of China"
            },
            {
                "name": "Yue Xiao",
                "org": "University of Electronic Science and Technology of China"
            },
            {
                "name": "Lixia Xiao",
                "org": "University of Electronic Science and Technology of China"
            },
            {
                "name": "Ping Yang",
                "org": "University of Electronic Science and Technology of China"
            },
            {
                "name": "Xia Lei",
                "org": "University of Electronic Science and Technology of China"
            }
        ],
        "venue": "ICC",
        "year": 2018
    },
    "ZnaXdlNy": {
        "id": "ZnaXdlNy",
        "title": "Power Allocation-Aided Spatial Modulation for Limited-Feedback MIMO Systems",
        "abstract": "Adaptive power allocation (PA) algorithms based on optimization of the minimum distance dmin between signal points at the receiver side are investigated in spatial modulation (SM) systems. First, a closed-form solution of the optimal maximum-dmin-aided PA algorithm is derived in the case of two transmit antennas (TAs). Moreover, for a higher number of TAs, we propose a numerical approach, which appropriately splits the power between the specific TA pair associated with dmin to increase this distance. Furthermore, our PA-aided SM systems may be readily combined with adaptive modulation (AM) to further improve the system's performance. Our numerical results show that the proposed algorithms provide beneficial system performance improvements compared with both the equal-gain PA-based SM and the identical-throughput PA-aided spatial multiplexing systems.",
        "keywords": [
            "mimo communication",
            "adaptive modulation",
            "numerical analysis",
            "space division multiplexing",
            "transmitting antennas",
            "am",
            "sm systems",
            "adaptive pa algorithms",
            "closed-form solution",
            "identical-throughput spatial multiplexing systems",
            "limited-feedback mimo systems",
            "numerical approach",
            "power allocation-aided spatial modulation",
            "receiver side",
            "signal points",
            "specific ta pair",
            "transmit antennas",
            "limited-feedback systems",
            "multiple-input???multiple-output (mimo)",
            "power allocation (pa)",
            "spatial modulation (sm)",
            "antennas",
            "algorithms",
            "modulation",
            "transmission",
            "vectors",
            "bit error rate",
            "closed form solution",
            "mimo",
            "optimization",
            "adaptive control",
            "resource management"
        ],
        "authors": [
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "yue xiao",
                "org": ""
            },
            {
                "name": "bo zhang",
                "org": ""
            },
            {
                "name": "shaoqian li",
                "org": ""
            },
            {
                "name": "Mohammed El-Hajjar",
                "org": ""
            },
            {
                "name": "lajos hanzo",
                "org": ""
            }
        ],
        "venue": "Vehicular Technology, IEEE Transactions",
        "year": 2014
    },
    "dzTE4mcr": {
        "id": "dzTE4mcr",
        "title": "Low-complexity non-coherent detection for spatial modulation OFDM systems",
        "abstract": "This letter describes a differential modulation scheme for spatial modulation orthogonal frequency division multiplexing (SM OFDM), aiming at developing low-complexity non-coherent detection without channel state information (CSI) at the receiver. By employing differential phase-shift keying (DPSK) between nonzero subcarrier at each transmit antenna, the proposed method can work with any number of transmit and receive antennas to realize high bandwidth efficiency. Additionally, the reference symbols at each transmit antenna are initialized at particular subcarriers, which are utilized to estimate the antenna indices at the receiver. Simulation results show that the proposed scheme gives rise to reasonable performance penalty in comparison to coherent SM OFDM. \u00a9 2012 IEEE.",
        "keywords": [
            "differential modulation",
            "multiple input multiple output (mimo)",
            "orthogonal frequency division multiplexing (ofdm)",
            "spatial modulation (sm)"
        ],
        "authors": [
            {
                "name": "Lixia Xiao",
                "org": "National Key Laboratory of Science and Technology on Communications(National Key Laboratory of Science and Technology on Vacuum Electronics,National Key Laboratory of Science and Technology on Communications),Chengdu,China"
            },
            {
                "name": "Xu He",
                "org": "National Key Laboratory of Science and Technology on Communications(National Key Laboratory of Science and Technology on Vacuum Electronics,National Key Laboratory of Science and Technology on Communications),Chengdu,China"
            },
            {
                "name": "Yue Xiao",
                "org": "National Key Laboratory of Science and Technology on Communications(National Key Laboratory of Science and Technology on Vacuum Electronics,National Key Laboratory of Science and Technology on Communications),Chengdu,China"
            },
            {
                "name": "Ping Yang",
                "org": "National Key Laboratory of Science and Technology on Communications(National Key Laboratory of Science and Technology on Vacuum Electronics,National Key Laboratory of Science and Technology on Communications),Chengdu,China"
            },
            {
                "name": "Shaoqian Li",
                "org": "National Key Laboratory of Science and Technology on Communications(National Key Laboratory of Science and Technology on Vacuum Electronics,National Key Laboratory of Science and Technology on Communications),Chengdu,China"
            }
        ],
        "venue": "International Conference on Communication Technology Proceedings, ICCT",
        "year": 2012
    },
    "3eMrtB7q": {
        "id": "3eMrtB7q",
        "title": "Unified Power Allocation for Receive Spatial Modulation Based on Approximate Optimization.",
        "abstract": "In this paper, a novel unified power allocation (PA) framework is proposed for receive (pre-coding aided) spatial modulation (RSM). We find that the PA matrix design can be formulated as a non-convex quadratically constrained quadratic program (QCQP) problem, whose solution is generally intractable. To tackle this problem, we propose a pair of solvers having different trade-offs in terms of bit-error-rate and complexity. Specifically, we first propose a successive convex approximation (SCA) method, to convert the non-convex QCQP problem under consideration into a series of linear convex subproblems, where the latter can be easily solved by the classic polynomial-time-based optimization method, i.e., the interior point method. To further reduce the computational complexity, we propose an augmented Lagrangian multiplier (ALM) method, which transforms the challenging non-convex constrained PA optimization problem into its unconstrained counterpart, which can be efficiently solved by an iterative manner. Our simulation results show that both the proposed SCA and ALM methods are capable of substantially improving the system error performance compared with the conventional RSM system without PA as well as conventional PA-aided RSM schemes.",
        "keywords": "",
        "authors": [
            {
                "name": "Ping Yang",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Jing Zhu",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Zi Long Liu",
                "org": ""
            },
            {
                "name": "Yue Xiao",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Shaoqian Li",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Wei Xiang",
                "org": "College of Science and Engineering, James Cook University, Cairns, Australia"
            }
        ],
        "venue": "IEEE Access",
        "year": 2018
    },
    "WC1v0ads": {
        "id": "WC1v0ads",
        "title": "Low-complexity tree search-based detection algorithms for generalized spatial modulation aided single carrier systems.",
        "abstract": "In this paper, we design the low-complexity tree search-based detectors for generalized spatial modulation (GSM) aided single carrier (SC) systems over dispersive channels. Specifically, we commence with a brief review of the existing detection algorithms and then extend the sphere decoding-aided (SD) tree search algorithms designed for flat fading channels to GSM-aided SC systems. Moreover, a pair of reduced-complexity tree search algorithms are proposed by employing a hybrid concept of SD and M-algorithm to balance a tradeoff between the performance and complexity. Our proposed detectors are capable of recovering the transmit signal for both the overdetermine and underdetermine antenna configurations. Simulation results show that: 1) the extended SD-aided tree search algorithms are capable of providing the same performance as the maximum likelihood (ML) algorithm with reduced complexity; 2) the proposed novel algorithms exhibit lower complexity with negligible performance loss, compared with other tree search algorithms.",
        "keywords": "",
        "authors": [
            {
                "name": "Lixia Xiao",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Yan Zhao",
                "org": ""
            },
            {
                "name": "Yue Xiao",
                "org": ""
            },
            {
                "name": "Jiang Liu",
                "org": ""
            },
            {
                "name": "Shaoqian Li",
                "org": ""
            }
        ],
        "venue": "ICC",
        "year": 2016
    },
    "XXBmWJmg": {
        "id": "XXBmWJmg",
        "title": "Low-Complexity Signal Detection for Large-Scale Quadrature Spatial Modulation Systems.",
        "abstract": "In this letter, a novel low-complexity detector based on the concept of compressive sensing (CS) is proposed for a novel multiple-input multiple-output system, namely, quadrature spatial modulation (QSM). In particular, the CS algorithm is performed in the real-valued system model, and the activated antenna indices, which are used to transmit the real and imaginary parts of QSM symbols, can be estimated separately. In order to further improve the performance of QSM, a novel search strategy is proposed. Simulation results show that the proposed detector is capable of achieving a considerable reduction in complexity compared with the maximum likelihood counterpart with negligible performance loss.",
        "keywords": [
            "Detectors",
            "Complexity theory",
            "Indexes",
            "Matching pursuit algorithms",
            "GSM",
            "Modulation",
            "MIMO"
        ],
        "authors": [
            {
                "name": "Lixia Xiao",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Shiwen Fan",
                "org": ""
            },
            {
                "name": "Shaoqian Li",
                "org": ""
            },
            {
                "name": "Lijun Song",
                "org": ""
            },
            {
                "name": "Yue Xiao",
                "org": ""
            }
        ],
        "venue": "IEEE Communications Letters",
        "year": 2016
    },
    "hWfwhe41": {
        "id": "hWfwhe41",
        "title": "Soft-Feedback Time-Domain Turbo Equalization for Single-Carrier Generalized Spatial Modulation.",
        "abstract": "In this paper, a new class of soft-decision feedback aided time-domain turbo equalizer (TDTE) based on the minimum mean-square error criterion is proposed for broadband single-carrier (SC) generalized spatial modulation (GSM) systems. First, a time-domain soft-decision feedback (TDSDF) aided TDTE is proposed, which operates on a vector-by-vector basis. In order to provide a flexible tradeoff between complexity and performance, time-invariant filter coefficients are derived to provide a low-complexity approximate solution to the proposed TDSDF-TDTE. Furthermore, a soft-feedback interference cancelation (SFIC) aided TDTE is proposed for SC-GSM systems with a lower complexity, where the computation of the second-order moment of matrices is completely avoided. Finally, bi-directional soft-decision feedback aided TDTEs are proposed by using a time-reversed TDSDF-TDTE/SFIC-TDTE in conjunction with a ordinary TDSDF-TDTE/SFIC-TDTE so as to harvest time-reverse diversity and to mitigate the error propagation. An extrinsic information transfer chart based analysis and bit error rate simulation results are presented to demonstrate the superior performance of the proposed soft-decision feedback aided TDTEs as opposed to the original TDTEs, while achieving a lower complexity.",
        "keywords": "",
        "authors": [
            {
                "name": "Yan Zhao",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Ping Yang",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Yue Xiao",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Binhong Dong",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Wei Xiang",
                "org": "College of Science and Engineering, James Cook University, Cairns, Australia"
            }
        ],
        "venue": "IEEE Trans. Vehicular Technology",
        "year": 2018
    },
    "03lOQHsF": {
        "id": "03lOQHsF",
        "title": "Space-Time/Frequency Line Coded OFDM: System Design and Practical Implementation",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Chaowu Wu",
                "org": ""
            },
            {
                "name": "Yue Xiao",
                "org": ""
            },
            {
                "name": "Yong Liang Guan",
                "org": ""
            },
            {
                "name": "Jinfu Wang",
                "org": ""
            },
            {
                "name": "Xun Li",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            }
        ],
        "venue": "IEEE Access",
        "year": 2019
    },
    "pwPlFX31": {
        "id": "pwPlFX31",
        "title": "Compressed-Sensing Assisted Spatial Multiplexing Aided Spatial Modulation.",
        "abstract": "Spatial-multiplexing aided spatial modulation (SMx-SM) is proposed, which intrinsically amalgamates the concept of vertical bell labs space-time (V-BLAST) and SM to attain a high transmission rate, despite its low number of radio frequency (RF) chains at the transmitter. Specifically, in the SMx-SM scheme, the transmit antennas are partitioned into groups and the SM technique is applied individually to each group. Furthermore, low-complexity threshold-aided compressive sensing-based and message passing-based detectors are derived for our SMx-SM system. Our simulation results show that the proposed SMx-SM system exhibits a better performance despite its lower complexity than the conventional generalized spatial modulation system. More importantly, the proposed SMx-SM system is capable of providing considerable performance gains over the V-BLAST system at the same number of RF chains and throughput. Finally, an upper bound is derived for the average bit error probability, which is confirmed by our simulation results.",
        "keywords": "",
        "authors": [
            {
                "name": "Lixia Xiao",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Yue Xiao",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Chao Xu",
                "org": "School of Electronics and Computer Science, University of Southampton, Southampton, U.K."
            },
            {
                "name": "Xia Lei",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Ping Yang",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Shaoqian Li",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Lajos Hanzo",
                "org": "School of Electronics and Computer Science, University of Southampton, Southampton, U.K."
            }
        ],
        "venue": "IEEE Trans. Wireless Communications",
        "year": 2018
    },
    "XkGzHWnO": {
        "id": "XkGzHWnO",
        "title": " Joint Iterative Channel Estimation and Frequency-Domain Turbo Equalization for Single-Carrier Spatial Modulation",
        "abstract": "Single-carrier frequency-domain turbo equalization (SC-FDTE) has gained widespread adoption in the emerging broadband spatial modulation (SM) systems operating in frequency-selective channels, where the channel model considered is a quasi-static Rayleigh fading channel. In this paper, a new class of robust FDTE designs based on the minimum mean-square error (MMSE) criterion is conceived for broadband single-carrier SM (SC-SM) systems relying on realistic imperfect channel knowledge. First, a robust time-domain soft-decision feedback (TDSDF)-aided FDTE is proposed to cope with channel estimation errors at the receiver. Furthermore, its robust frequency-domain soft-decision feedback (FDSDF)-aided counterpart is derived to offer a low-complexity approximate solution. Finally, by exploiting the carefully selected reliable soft-decision output of the channel decoder as pilots, we refine the resultant decision-directed channel estimation. As a benefit, the performance of the two robust FDTEs can be further improved. Both our simulation results and our extrinsic information transfer (EXIT) chart analysis demonstrate that the proposed robust FDTEs achieve significant performance improvements over the conventional FDTEs.",
        "keywords": [
            "Channel estimation",
            "Frequency-domain analysis",
            "Receivers",
            "Decision feedback equalizers",
            "Broadband communication",
            "Fading channels"
        ],
        "authors": [
            {
                "name": "Yan Zhao",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Yue Xiao",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Ping Yang",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Binhong Dong",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Lajos Hanzo",
                "org": "School of Electronics and Computer Science, University of Southampton, Southampton, U.K."
            }
        ],
        "venue": "IEEE Transactions on Communications",
        "year": 2019
    },
    "tyBzx9FE": {
        "id": "tyBzx9FE",
        "title": "Low RF-Complexity Receive Spatial Modulation for Millimeter-Wave MIMO Communications.",
        "abstract": "A novel low RF-complexity multiple-input multiple-output (MIMO) transmission scheme, termed analog beamforming aided receive spatial modulation (AB-RSM), is proposed for millimeter-wave (mmWave) communications. We investigate the transmitter design employing the RSM concept and analog beamforming technique in mmWave MIMO systems. To introduce beamforming gain while maintaining the advantages of RSM, we employ the phase shifters at the transmitter to make all the transmit antennas aim at the activated receive antenna. Our simulation results show that the proposed AB-RSM scheme is capable of achieving reduced computational complexity as well as hardware cost compared to the conventional RSM, especially for large-scale scenarios.",
        "keywords": "",
        "authors": [
            {
                "name": "Jing Zhu",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Sichuan, China"
            },
            {
                "name": "Ping Yang",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Sichuan, China"
            },
            {
                "name": "Yue Xiao",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Sichuan, China"
            },
            {
                "name": "Xia Lei",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Sichuan, China"
            },
            {
                "name": "Qiong Chen",
                "org": "Algorithm Department, ZTE Corporation, Nanjing, China"
            }
        ],
        "venue": "IEEE Communications Letters",
        "year": 2018
    },
    "6DVapQ8c": {
        "id": "6DVapQ8c",
        "title": "Subcarrier Allocation for OFDM With Index Modulation.",
        "abstract": "Subcarrier allocation (SA) scheme was demonstrated to provide useful performance improvements for orthogonal frequency division multiplexing (OFDM) systems. Hence, in this letter, we extend its employment to OFDM with index modulation (OFDM-IM) systems. For the sake of improving the bit error rate (BER) performance, an optimal SA algorithm is first proposed by maximazing the average minimum Euclidean distance (AMED) based on exhaustive search. Furthermore, for striking a better tradeoff between the complexity imposed and the BER performance attained, we propose a simplified SA algorithm by sorting the channel gains of the subcarriers. Simulation results show that with the aid of SA algorithms, significant performance gains can be achieved over conventional OFDM-IM systems.",
        "keywords": [
            "Index modulation",
            "orthogonal frequency division multiplexing",
            "subcarrier allocation"
        ],
        "authors": [
            {
                "name": "Qianli Ma",
                "org": ""
            },
            {
                "name": "Yue Xiao",
                "org": ""
            },
            {
                "name": "Lilin Dan",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Lan Peng",
                "org": ""
            },
            {
                "name": "Shaoqian Li",
                "org": ""
            }
        ],
        "venue": "IEEE Communications Letters",
        "year": 2016
    },
    "vOYwDJjH": {
        "id": "vOYwDJjH",
        "title": "Phase rotation-based precoding for spatial modulation systems",
        "abstract": "In this study, the authors investigate the benefits of phase-rotation-assisted precoding (PRP) technique in spatial modulation (SM) systems, which are based on maximum free distance dmin. First, a closed-form solution of the maximum-dmin PRP matrix is derived for the scenario of having two transmit antennas (Nt = 2). Moreover, two numerical methods are proposed for dealing with the case of Nt > 2. The complexity of the proposed algorithms is presented. The authors simulation results show that the proposed PRP algorithms provide beneficial bit error ratio performance improvements compared with both the conventional SM and with the existing adaptive SM.",
        "keywords": [],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "university of electronic science and technology of china"
            },
            {
                "name": "Yue Xiao",
                "org": "university of electronic science and technology of china"
            },
            {
                "name": "Bo Zhang",
                "org": "school of electronics and computer science university of southampton"
            },
            {
                "name": "Mohammed El-Hajjar",
                "org": "school of electronics and computer science university of southampton"
            },
            {
                "name": "Shaoqian Li",
                "org": "university of electronic science and technology of china"
            },
            {
                "name": "Lajos Hanzo",
                "org": "school of electronics and computer science university of southampton"
            }
        ],
        "venue": "IET Communications",
        "year": 2015
    },
    "UO7koOj3": {
        "id": "UO7koOj3",
        "title": "Improved Layered Message Passing Algorithms for Large-Scale Generalized Spatial Modulation Systems.",
        "abstract": "Generalized spatial modulation (GSM) is a novel multiple-input multiple-output technique, which relies on a sparse use of radio-frequency front-ends at the transmitter. In this letter, a pair of detectors based on the layered message passing (LaMP) detector are proposed for large-scale GSM. Specifically, a threshold-aided LaMP detector (T-LaMP) is proposed with the purpose of reducing the computational complexity of LaMP detector. In addition, for the sake of achieving further GSM system performance improvements, a probability-ranking-aided LaMP detector (PR-LaMP) is also proposed. Simulation results show that T-LaMP detector is able to achieve similar performance as LaMP with lower complexity, while PR-LaMP detector is able to achieve considerable performance gain.",
        "keywords": [
            "GSM",
            "Detectors",
            "Transmitting antennas",
            "Complexity theory",
            "Message passing",
            "MIMO"
        ],
        "authors": [
            {
                "name": "Shiwen Fan",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Yue Xiao",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Lixia Xiao",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Ping Yang",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Shi Rong",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Deng Ke",
                "org": ""
            }
        ],
        "venue": "IEEE Wireless Commun. Letters",
        "year": 2018
    },
    "GyhsuiJ8": {
        "id": "GyhsuiJ8",
        "title": "Efficient Receive Antenna Selection for Pre-Coding Aided Spatial Modulation.",
        "abstract": "Developed from the recently emerged pre-coding aided spatial modulation (PSM) concept, a class of efficient receives antenna selection (ERAS) techniques are devised. Aiming at approaching the optimal RAS performance in context of the PAM system, we derive the upper bound performance of RAS-PAM in two different ways, by utilizing the condition number and eigenvalue and Wishart distribution feature for the channel matrix. Our performance results demonstrate that the proposed ERAS techniques are capable of effectively improving the transmission performance in comparison with conventional RAS-PSM systems.",
        "keywords": "",
        "authors": [
            {
                "name": "Peibo Wen",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Sichuan, China"
            },
            {
                "name": "Xu He",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Sichuan, China"
            },
            {
                "name": "Yue Xiao",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Sichuan, China"
            },
            {
                "name": "Ping Yang",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Sichuan, China"
            },
            {
                "name": "Shi Rong",
                "org": ""
            },
            {
                "name": "Deng Ke",
                "org": ""
            }
        ],
        "venue": "IEEE Communications Letters",
        "year": 2018
    },
    "Ffs5u9KS": {
        "id": "Ffs5u9KS",
        "title": "Hybrid Bit-to-Symbol Mapping for Spatial Modulation.",
        "abstract": "In spatial modulation (SM), the information bit stream is divided into two different sets: the transmit antenna index bits (TA-bits) and the amplitude and phase modulation bits (APM-bits). However, the conventional bit-to-symbol mapping (BTS-MAP) scheme maps the APM-bits and the TA-bits independently. For exploiting their joint benefits, we propose a new BTS-MAP rule based on the traditional 2-D Gray mapping rule, which increases the Hamming distance (HD) between the symbol pairs detected from the same transmit antenna (TA) and simultaneously reduces the average HD between the symbol pairs gleaned from different TAs. Based on the analysis of the distribution of minimum Euclidean distance (MED) of SM constellations, we propose a criterion for the construction of a meritorious BTS-MAP for a specific SM setup, with no need for additional feedback links or extra computational complexity. Finally, Monte Carlo simulations are conducted for confirming the accuracy of our analysis.",
        "keywords": "",
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Yue Xiao",
                "org": ""
            },
            {
                "name": "Lu Yin",
                "org": ""
            },
            {
                "name": "Qian Tang",
                "org": ""
            },
            {
                "name": "Shaoqian Li",
                "org": ""
            },
            {
                "name": "Lajos Hanzo",
                "org": ""
            }
        ],
        "venue": "IEEE Trans. Vehicular Technology",
        "year": 2016
    },
    "YqI8oiLd": {
        "id": "YqI8oiLd",
        "title": "Adaptive Spatial Modulation MIMO Based on Machine Learning",
        "abstract": "In this paper, we propose a novel framework of low-cost link adaptation for spatial modulation multiple-input multiple-output (SM-MIMO) systems-based upon the machine learning paradigm. Specifically, we first convert the problems of transmit antenna selection (TAS) and power allocation (PA) in SM-MIMO to ones-based upon data-driven prediction rather than conventional optimization-driven decisions. Then, supervised-learning classifiers (SLC), such as the \n<inline-formula xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"> <tex-math notation=\"LaTeX\">$K$ </tex-math></inline-formula>\n-nearest neighbors (KNN) and support vector machine (SVM) algorithms, are developed to obtain their statistically-consistent solutions. Moreover, for further comparison we integrate deep neural networks (DNN) with these adaptive SM-MIMO schemes, and propose a novel DNN-based multi-label classifier for TAS and PA parameter evaluation. Furthermore, we investigate the design of feature vectors for the SLC and DNN approaches and propose a novel feature vector generator to match the specific transmission mode of SM. As a further advance, our proposed approaches are extended to other adaptive index modulation (IM) schemes, e.g., adaptive modulation (AM) aided orthogonal frequency division multiplexing with IM (OFDM-IM). Our simulation results show that the SLC and DNN-based adaptive SM-MIMO systems outperform many conventional optimization-driven designs and are capable of achieving a near-optimal performance with a significantly lower complexity.",
        "keywords": [
            "Machine learning",
            "MIMO communication",
            "Adaptive systems",
            "Indexes",
            "Modulation",
            "Complexity theory",
            "Support vector machines"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Sichuan, China"
            },
            {
                "name": "Yue Xiao",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Sichuan, China"
            },
            {
                "name": "Ming Xiao",
                "org": "Information Science and Engineering (ISE) Department, School of Electrical Engineering, KTH Royal Institute of Technology, Stockholm, Sweden"
            },
            {
                "name": "Yong Liang Guan",
                "org": "School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore"
            },
            {
                "name": "Shaoqian Li",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Sichuan, China"
            },
            {
                "name": "Wei Xiang",
                "org": "College of Science and Engineering, James Cook University, Cairns, QLD, Australia"
            }
        ],
        "venue": "IEEE Journal on Selected Areas in Communications",
        "year": 2019
    },
    "OcXvjyY8": {
        "id": "OcXvjyY8",
        "title": "An Iterative CFO Compensation Algorithm for Distributed Spatial Modulation OFDM Systems",
        "abstract": "Spatial Modulation (SM), conveying data bits via the antenna-activation process, is a novel modulation technique for multiple-input multiple-output (MIMO) systems. SM can be combined with orthogonal frequency division multiplexing (OFDM) to improve the reliability, quality and capacity of transmission. However, SM OFDM systems also inherit from OFDM systems the drawback of high sensitivity to carrier frequency offset (CFO), especially in distributed MIMO environment where the CFOs of all transmit antennas are different. To overcome this problem, in this paper, the CFO characteristics of distributed SM OFDM systems are studied and a new iterative CFO compensation algorithm which exploits the interference effect caused by each antenna's CFO is proposed. Moreover, the information-conveying feature of SM system is applied to the proposed CFO compensation algorithm to reduce the computational complexity and provide fast compensation of CFOs. Simulation results show that the proposed CFO compensator achieves considerable performance improvement with low complexity.",
        "keywords": [
            "multiple input multiple output",
            "carrier frequency offset (cfo)",
            "transmit antennas",
            "transmitting antennas",
            "distributed spatial modulation",
            "interference effect",
            "ofdm modulation",
            "orthogonal frequency division multiplexing",
            "orthogonal frequency division multiplexing (ofdm)",
            "space division multiplexing",
            "iterative cfo compensation",
            "mimo communication",
            "carrier frequency offset",
            "compensation",
            "spatial modulation (sm)",
            "ofdm systems",
            "interference suppression",
            "spatial modulation",
            "antenna-activation process",
            "mimo",
            "iterative methods",
            "interference",
            "computational complexity",
            "bit error rate",
            "ofdm"
        ],
        "authors": [
            {
                "name": "Bin Zhou",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            },
            {
                "name": "Yue Xiao",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            },
            {
                "name": "Ping Yang",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            },
            {
                "name": "Shaoqian Li",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            }
        ],
        "venue": "Wireless Communications, Networking and Mobile Computing",
        "year": 2011
    },
    "vc2iBYGv": {
        "id": "vc2iBYGv",
        "title": "Single-Carrier SM-MIMO: A Promising Design for Broadband Large-Scale Antenna Systems.",
        "abstract": "The main limitations of employing large-scale antenna (LSA)\u00a0architectures for broadband frequency-selective channels include, but are not limited to their complexity, power consumption, and the high cost of multiple radio frequency (RF)\u00a0chains. Promising solutions can be found in the recently proposed family of single-carrier (SC)\u00a0spatial modulation (SM)\u00a0transmission techniques. Since the SM scheme\u2019s transmit antenna (TA)\u00a0activation process is carried out in the context of a SC-SM architecture, the benefits of a low-complexity and low-cost single-RF transmitter are maintained, while a high MIMO multiplexing gain can be attained. Moreover, owing to its inherent SC structure, the transmit signals of SC-SM have attractive peak power characteristics and a high robustness to RF hardware impairments, such as the RF carrier frequency offset (CFO)\u00a0and phase noise. In this paper, we present a comprehensive overview of the latest research achievements of SC-SM, which has recently attracted considerable attention. We outline the associated transceiver design, the benefits and potential tradeoffs, the LSA aided multiuser (MU)\u00a0transmission developments, the relevant open research issues as well as the potential solutions of this appealing transmission technique.",
        "keywords": "",
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Yue Xiao",
                "org": ""
            },
            {
                "name": "Yong Liang Guan",
                "org": ""
            },
            {
                "name": "K. V. S. Hari",
                "org": ""
            },
            {
                "name": "A. Chockalingam",
                "org": ""
            },
            {
                "name": "Shinya Sugiura",
                "org": ""
            },
            {
                "name": "Harald Haas",
                "org": ""
            },
            {
                "name": "Marco Di Renzo",
                "org": ""
            },
            {
                "name": "Christos Masouros",
                "org": ""
            },
            {
                "name": "Zi Long Liu",
                "org": ""
            },
            {
                "name": "Lixia Xiao",
                "org": ""
            },
            {
                "name": "Shaoqian Li",
                "org": ""
            },
            {
                "name": "Lajos Hanzo",
                "org": ""
            }
        ],
        "venue": "IEEE Communications Surveys and Tutorials",
        "year": 2016
    },
    "5MwDXODe": {
        "id": "5MwDXODe",
        "title": "An Improved Frequency Domain Turbo Equalizer for Single-Carrier Spatial Modulation Systems.",
        "abstract": "In this paper, a new time-domain soft-decision feedback (TDSDF) aided frequency domain turbo equalizer (FDTE) is proposed for broadband single-carrier (SC) spatial modulation (SM) systems. Specifically, the proposed equalizer operates on a frame-by-frame basis and is designed based on the minimum block-averaged mean-square error (MBMSE) criterion. To tackle the error propagation problem, a metric in consideration of the reliability of the feedback information is considered. The optimal coefficients of the forward and feedback filters involved in the TDSDF-FDTE design are derived analytically. Simulation results show that the proposed nonlinear TDSDF-FDTE detector is capable of offering a better tradeoff between the bit-error-rate (BER) performance and the imposed computational complexity than the conventional linear frequency domain turbo demapper (FDTD) conceived for SC-SM systems. Furthermore, a 4 dB improvement is observed for the unbalanced channel.",
        "keywords": "",
        "authors": [
            {
                "name": "Yan Zhao",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Sichuan, China"
            },
            {
                "name": "Ping Yang",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Sichuan, China"
            },
            {
                "name": "Yue Xiao",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Sichuan, China"
            },
            {
                "name": "Lixia Xiao",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Sichuan, China"
            },
            {
                "name": "Binhong Dong",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Sichuan, China"
            },
            {
                "name": "Wei Xiang",
                "org": "College of Science and Engineering, James Cook University, Cairns, QLD, Australia"
            }
        ],
        "venue": "IEEE Trans. Vehicular Technology",
        "year": 2017
    },
    "5d83qUyu": {
        "id": "5d83qUyu",
        "title": "A Low-Complexity Ordered Sphere Decoding Algorithm for Spatial Modulation.",
        "abstract": "",
        "keywords": [
            "mimo",
            "mf"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Yue Xiao",
                "org": ""
            },
            {
                "name": "Qian Tang",
                "org": ""
            },
            {
                "name": "Bin Zhou",
                "org": ""
            },
            {
                "name": "Shaoqian Li",
                "org": ""
            }
        ],
        "venue": "IEICE Transactions",
        "year": 2012
    },
    "tJySgrh3": {
        "id": "tJySgrh3",
        "title": "6G Wireless Communications: Vision and Potential Techniques",
        "abstract": "With the fast development of smart terminals and emerging new applications (e.g., real-time and interactive services), wireless data traffic has drastically increased, and current cellular networks (even the forthcoming 5G) cannot completely match the quickly rising technical requirements. To meet the coming challenges, the sixth generation (6G) mobile network is expected to cast the high technical standard of new spectrum and energy-efficient transmission techniques. In this article, we sketch the potential requirements and present an overview of the latest research on the promising techniques evolving to 6G, which have recently attracted considerable attention. Moreover, we outline a number of key technical challenges as well as the potential solutions associated with 6G, including physical-layer transmission techniques, network designs, security approaches, and testbed developments.",
        "keywords": "",
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Yue Xiao",
                "org": ""
            },
            {
                "name": "Ming Xiao",
                "org": ""
            },
            {
                "name": "Shaoqian Li",
                "org": ""
            }
        ],
        "venue": "IEEE Network",
        "year": 2019
    },
    "npLdCra3": {
        "id": "npLdCra3",
        "title": "Energy Borrowing: An Efficient Way to Bridge Energy Harvesting and Power Grid in Wireless Communications.",
        "abstract": "Conventional energy harvesting (EH) communications are limited by energy unsteadiness and causality. In this paper, a novel technique namely energy borrowing (EB) is specifically designed as an efficient way to bridge energy harvesting and power grid in wireless communications. The EH nodes are capable of adaptively borrowing and returning energy from the power grid, at the cost of paying extra energy interest. In order to maximize the transmission throughput, the packets scheduling problem in the proposed EB-aided EH systems is investigated and adaptive solutions are developed. Simulation results show that the proposed EB-aided EH system provides throughput improvement over the conventional one without EB, while achieving extra energy benefits for the power grid.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhaojie Sun",
                "org": ""
            },
            {
                "name": "Lilin Dan",
                "org": ""
            },
            {
                "name": "Yue Xiao",
                "org": ""
            },
            {
                "name": "Peibo Wen",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Shaoqian Li",
                "org": ""
            }
        ],
        "venue": "VTC Spring",
        "year": 2016
    },
    "9MQ8JtXy": {
        "id": "9MQ8JtXy",
        "title": "Power scaling for spatial modulation with limited feedback",
        "abstract": "Spatial modulation (SM) is a recently developed multiple-input multiple-output (MIMO) technique which offers a new tradeoff between spatial diversity and spectrum efficiency, by introducing the indices of transmit antennas as a means of information modulation. Due to the special structure of SM-MIMO, in the receiver, maximum likelihood (ML) detector can be combined with low complexity. For further improving the system performance with limited feedback, in this paper, a novel power scaling spatial modulation (PS-SM) scheme is proposed. The main idea is based on the introduction of scaling factor (SF) for weighting the modulated symbols on each transmit antenna of SM, so as to enlarge the minimal Euclidean distance of modulated constellations and improve the system performance. Simulation results show that the proposed PS-SM outperforms the conventional adaptive spatial modulation (ASM) with the same feedback amount and similar computational complexity. \u00a9 2013 Yue Xiao et al.",
        "keywords": [],
        "authors": [
            {
                "name": "Yue Xiao",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            },
            {
                "name": "Qian Tang",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            },
            {
                "name": "LiSha Gong",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            },
            {
                "name": "Ping Yang",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            },
            {
                "name": "Zongfei Yang",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            }
        ],
        "venue": "International Journal of Antennas and Propagation",
        "year": 2013
    },
    "ymMCOLz3": {
        "id": "ymMCOLz3",
        "title": " Approximate Message Passing Detector Based Upon Probability Sorting for Large-Scale GSM Systems",
        "abstract": "Large-scale generalized spatial modulation (GSM) technology has great potential in constructing low-complexity massive multiple-input multiple-output wireless systems, with a simplified structure which employs only a few radio frequency (RF) chains. However, detection is a very complex problem for large-scale GSM systems. In this correspondence paper, we have proposed an innovative probability sorting based approximate message passing (PS-AMP) detector. Specifically, in the proposed scheme, an approximate message passing method is used to obtain the probability for activation of each transmit antenna, and a method based upon probability sorting is developed to ascertain the signal search space. Simulation results demonstrate that the proposed PS-AMP detector exhibits a better bit error rate performance with a reduced complexity compared to its conventional counterparts.",
        "keywords": [
            "Detectors",
            "GSM",
            "Message passing",
            "Transmitting antennas",
            "Sorting",
            "MIMO communication",
            "Complexity theory"
        ],
        "authors": [
            {
                "name": "Shiwen Fan",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Yue Xiao",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Ping Yang",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Lilin Dan",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Wei Xiang",
                "org": "College of Science and Engineering, James Cook University, Cairns, QLD, Australia"
            }
        ],
        "venue": "IEEE Transactions on Vehicular Technology",
        "year": 2019
    },
    "CyionTc0": {
        "id": "CyionTc0",
        "title": "A Low-Complexity Power Allocation Algorithm for Multiple-Input-Multiple-Output Spatial Modulation Systems.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Yue Xiao",
                "org": ""
            },
            {
                "name": "Shaoqian Li",
                "org": ""
            },
            {
                "name": "Lajos Hanzo",
                "org": ""
            }
        ],
        "venue": "IEEE Trans. Vehicular Technology",
        "year": 2016
    },
    "raUa8xot": {
        "id": "raUa8xot",
        "title": "Cross-Entropy-Based Antenna Selection for Spatial Modulation.",
        "abstract": "Euclidean distance optimized antenna selection (EDAS) can significantly improve the bit-error-rate (BER) performance of spatial modulation (SM) systems. However, the exhaustive search over all possible antenna subsets leads to inherently high-search complexity. In this letter, a cross-entropy-based antenna selection (CEAS) scheme is proposed, by formulating the antenna selection problem in SM as a combinatorial optimization one. Simulation results show that the proposed CEAS scheme achieves considerable reduction in search complexity, while approaching the optimal performance of exhaustive search.",
        "keywords": [
            "Complexity theory",
            "Antennas",
            "Bit error rate",
            "Modulation",
            "Optimization",
            "MIMO",
            "Convergence"
        ],
        "authors": [
            {
                "name": "Zhaojie Sun",
                "org": ""
            },
            {
                "name": "Yue Xiao",
                "org": ""
            },
            {
                "name": "Longfei You",
                "org": ""
            },
            {
                "name": "Lu Yin",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Shaoqian Li",
                "org": ""
            }
        ],
        "venue": "IEEE Communications Letters",
        "year": 2016
    },
    "4DKK5BTK": {
        "id": "4DKK5BTK",
        "title": "Transmit Antenna Selection for Multiple-Input Multiple-Output Spatial Modulation Systems.",
        "abstract": "The benefits of transmit antenna selection (TAS) invoked for spatial modulation (SM) aided multiple-input multiple-output (MIMO)\u00a0systems are investigated. Specifically, we commence with a brief review of the existing TAS algorithms and focus on the recently proposed Euclidean distance-based TAS (ED-TAS) schemes due to their high diversity gain. Then, a pair of novel ED-TAS algorithms, termed as the improved QR decomposition (QRD)-based TAS (QRD-TAS) and the error-vector magnitude-based TAS (EVM-TAS) are proposed, which exhibit an attractive system performance at low complexity. Moreover, the proposed ED-TAS algorithms are amalgamated with the low-complexity yet efficient power allocation (PA)\u00a0technique, termed as TAS-PA, for the sake of further improving the system\u2019s performance. Our simulation results show that the proposed TAS-PA algorithms achieve signal-to-noise ratio (SNR)\u00a0gains of up to 9\u00a0dB over the conventional TAS algorithms and up to 6\u00a0dB over the TAS-PA algorithm designed for spatial multiplexing systems.",
        "keywords": "",
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Yue Xiao",
                "org": ""
            },
            {
                "name": "Yong Liang Guan",
                "org": ""
            },
            {
                "name": "Shaoqian Li",
                "org": ""
            },
            {
                "name": "Lajos Hanzo",
                "org": ""
            }
        ],
        "venue": "IEEE Trans. Communications",
        "year": 2016
    },
    "XYgYiZ8r": {
        "id": "XYgYiZ8r",
        "title": "A Low-complexity Detection Scheme for Generalized Spatial Modulation Aided Single Carrier Systems",
        "abstract": "Generalized spatial modulation (GSM), which combines spatial modulation (SM) and vertical Bell laboratories layered space-time (V-BLAST), is a novel attractive multi-input multi-output (MIMO) technique. In this Letter, a low-complexity nearoptimal detection scheme is presented for GSM aided single carrier (SC) transmission over dispersive channels. Compared to the conventional partial interference cancellation receiver with successive interference cancellation (PIC-R-SIC), the proposed scheme offers a near maximum likelihood (ML) detection performance while avoiding complicated matrix operations, which allows it to exhibit a lower computational complexity. Simulation results show that the proposed scheme provides a considerable performance improvement compared to PIC-R-SIC, especially in rank-deficient channels scenarios.",
        "keywords": [
            "Complexity theory",
            "GSM",
            "Modulation",
            "Detectors",
            "Bit error rate",
            "Vectors",
            "Receivers"
        ],
        "authors": [
            {
                "name": "Lixia Xiao",
                "org": ""
            },
            {
                "name": "Lilin Dan",
                "org": ""
            },
            {
                "name": "Yunjiao Zhang",
                "org": ""
            },
            {
                "name": "Yue Xiao",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Shaoqian Li",
                "org": ""
            }
        ],
        "venue": "IEEE Communications Letters",
        "year": 2015
    },
    "dva6FtB5": {
        "id": "dva6FtB5",
        "title": "Initial performance evaluation of spatial modulation OFDM in LTE-based systems",
        "abstract": "In this paper, we explore the spatial modulation (SM) orthogonal frequency division multiplexing (SM-OFDM) transmission to achieve good performance in Long Term Evolution (LTE) based systems. For assessment purposes, the performance results of SM-OFDM systems are compared with the popular Alamouti-coded OFDM systems and vertical Bell Labs layered space-time (V-BLAST) OFDM systems. Simulation results show that SM-OFDM systems achieve better performance than other systems at low spectral efficiencies. However, at high spectral efficiencies, the performance of SM depends on a trade-off between the spatial constellation size and signal constellation size. Furthermore, the results also show that SM provides a flexible transceiver configuration, especially for an unbalanced multiple-input multiple-output (MIMO) channel.",
        "keywords": [],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, Sichuan 611731, China"
            },
            {
                "name": "Yue Xiao",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, Sichuan 611731, China"
            },
            {
                "name": "Bin Zhou",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, Sichuan 611731, China"
            },
            {
                "name": "Shaoqian Li",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, Sichuan 611731, China"
            }
        ],
        "venue": "CHINACOM",
        "year": 2011
    },
    "Mv5vRAss": {
        "id": "Mv5vRAss",
        "title": "Power Allocation for Pre-Coding-Aided Spatial Modulation.",
        "abstract": "In this letter, power allocation (PA) algorithms based on the minimization of the upper bound of the instantaneous bit error probability (BEP) are investigated in pre-coding-aided spatial modulation (PSM) systems. First, an upper bound of the instantaneous BEP is derived when PA is taken into account for the antennas in the PSM system. Moreover, the optimal solution of the PA matrix is derived with the aid of convex optimization techniques, in order to minimize the BEP obtained. Furthermore, a low-complexity suboptimal PA algorithm is proposed, where only the dominant part of the BEP upper bound is considered in the optimization process. Simulation results demonstrate that the proposed algorithms improve on the conventional PSM scheme. Furthermore, when the number of receive antennas is large, the performance of the low-complexity suboptimal PA algorithm is close to that of the optimal PA algorithm.",
        "keywords": "",
        "authors": [
            {
                "name": "You Li",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Xia Lei",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Yue Xiao",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Ping Yang",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Chen Zheng",
                "org": "Science and Technology on Space Physics Laboratory, Beijing Institute of Nearspace Vehicle\u2019s systems Engineering, Beijing, China"
            },
            {
                "name": "Wei Xiang",
                "org": "College of Science and Engineering, James Cook University, Cairns Campus, Smithfield, QLD, Australia"
            }
        ],
        "venue": "IEEE Communications Letters",
        "year": 2018
    },
    "dIky2G2e": {
        "id": "dIky2G2e",
        "title": "Generalized Approximate Message Passing Aided Frequency Domain Turbo Equalizer for Single-Carrier Spatial Modulation.",
        "abstract": "In this paper, a pair of novel frequency domain equalizers for broadband single-carrier (SC) spatial modulation (SM) systems over dispersive channels are proposed by integrating with the concept of generalized approximate message passing (GAMP). Specifically, we first propose a GAMP-aided frequency domain turbo equalizer (FDTE-GAMP) operating on a vector-by-vector basis, which exploits the linear mixing channel structure composed of channel matrix and fast Fourier transforms. In the design of this novel detector, the non-Gaussian property of the transmitted SM symbol is fully investigated, in order to provide a more reliable belief of the channel symbols, leading to an accurate extrinsic information. For the sake of simplification, we propose a low-complexity version of FDTE-GAMP by forcing the variance components of transmitted symbols to be the same scalar, and thus avoiding the matrix inversion operation and maintaining a sequence of scalar operations. Simulation results show that the proposed equalizers are capable of providing a better tradeoff between the attainable bit error rate and the imposed computational complexity than the conventional FDTEs conceived for SC-SM systems.",
        "keywords": "",
        "authors": [
            {
                "name": "Yan Zhao",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Sichuan, China"
            },
            {
                "name": "Yue Xiao",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Sichuan, China"
            },
            {
                "name": "Ping Yang",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Sichuan, China"
            },
            {
                "name": "Binhong Dong",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Sichuan, China"
            },
            {
                "name": "Rong Shi",
                "org": "Science and Technology on Electronic Information Control Laboratory, 29th Research Institute of China Electronics Technology Group Corporation, Chengdu, China"
            },
            {
                "name": "Ke Deng",
                "org": "Science and Technology on Electronic Information Control Laboratory, 29th Research Institute of China Electronics Technology Group Corporation, Chengdu, China"
            }
        ],
        "venue": "IEEE Trans. Vehicular Technology",
        "year": 2018
    },
    "QHC35Wxi": {
        "id": "QHC35Wxi",
        "title": "An Improved Soft-Input Soft-Output Detector for Generalized Spatial Modulation",
        "abstract": "Generalized spatial modulation (GSM) is a recently proposed appealing multi-input multi-output (MIMO) transmission technique, which is capable of striking a tradeoff between the achievable transmission rate and the cost of radio frequency (RF) chains. In this letter, a novel low-complexity near-optimal soft decision (SoD)-aided detector is proposed for GSM, which considerably reduces the search space by employing a block minimum mean-squared error (B-MMSE) algorithm. Our simulation results show that the proposed detector is capable of achieving a better tradeoff between bit-error-rate (BER) performance and computational complexity compared with the existing matched filter (MF)-based SoD algorithms.",
        "keywords": [
            "Generalized spatial modulation (GSM)",
            "multi-input multi-output (MIMO)",
            "soft-input soft-output"
        ],
        "authors": [
            {
                "name": "Xiao, L.",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China|c|"
            },
            {
                "name": "Yang, P.",
                "org": ""
            },
            {
                "name": "Xiao, Y.",
                "org": ""
            },
            {
                "name": "Liu, J.",
                "org": ""
            }
        ],
        "venue": "Signal Processing Letters, IEEE",
        "year": 2015
    },
    "aTsC2XpJ": {
        "id": "aTsC2XpJ",
        "title": "A New Low-Complexity Near-ML Detection Algorithm for Spatial Modulation.",
        "abstract": "In this letter, we propose a distance-based ordered detection (DBD) algorithm for spatial modulation (SM) to reduce the receiver complexity and achieve a near maximum likelihood (ML) performance. The proposed algorithm firstly compensates the channel attenuation and obtains the estimated symbols with transmit antenna indices, then orders the indices based on the distances between these symbols and their demodulation constellations. A searching method is developed to obtain the final decision through a trade-off between performance and complexity. The equivalence between DBD and ML algorithms is also proved by theoretical analysis. Furthermore, a new low-complexity soft output DBD (SODBD) algorithm is developed for coded SM systems. The simulation results show that DBD algorithm has a close performance to ML algorithm while effectively reducing the complexity compared to conventional near-ML algorithms. \u00a9 2013 IEEE.",
        "keywords": [
            "Complexity theory",
            "Antennas",
            "Algorithm design and analysis",
            "Detection algorithms",
            "Demodulation",
            "Indexes"
        ],
        "authors": [
            {
                "name": "Qian Tang",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            },
            {
                "name": "Yue Xiao",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            },
            {
                "name": "Ping Yang",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            },
            {
                "name": "Qiaoling Yu",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            },
            {
                "name": "Shaoqian Li",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            }
        ],
        "venue": "Wireless Communications Letters, IEEE",
        "year": 2013
    },
    "LoXonOdf": {
        "id": "LoXonOdf",
        "title": "NOMA-Aided Precoded Spatial Modulation for Downlink MIMO Transmissions.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Yue Xiao",
                "org": ""
            },
            {
                "name": "Ming Xiao",
                "org": ""
            },
            {
                "name": "Zheng Ma",
                "org": ""
            }
        ],
        "venue": "J. Sel. Topics Signal Processing",
        "year": 2019
    },
    "hS8ya2W8": {
        "id": "hS8ya2W8",
        "title": "An Improved Matched-Filter Based Detection Algorithm for Space-Time Shift Keying Systems.",
        "abstract": "In this letter, an extension of the near-optimal matched-filter (NMF) detector that provides improvement of the performance with negligible extra complexity is proposed for space-time shift keying (STSK) systems. In contrast to the NMF which only utilizes the index of the most probable active dispersion-matrix (DM) for detection, the proposed method sorts the DM index set and achieves the final results from the $K$ most probable indices, so as to alleviate the error propagation caused by DM misdetection. Simulation results show that the proposed algorithm provides considerable performance improvement for both hard and soft output detection as compared to NMF. Furthermore, it is also shown that the proposed detector is capable of achieving the same performance as that of the exhaustive-search MF (EMF) detector at reduced complexity, especially for high data rates. \u00a9 2006 IEEE.",
        "keywords": [
            "matched-filter",
            "space-time shift keying",
            "spatial modulation",
            "vectors",
            "indexes",
            "estimation",
            "phase shift keying",
            "matched filters",
            "dispersion matrix",
            "exhaustive search",
            "indexation",
            "signal processing",
            "modulation",
            "error propagation",
            "delta modulation",
            "matched filter",
            "detectors",
            "space time"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Yue Xiao",
                "org": ""
            },
            {
                "name": "Lei Li",
                "org": ""
            },
            {
                "name": "Qian Tang",
                "org": ""
            },
            {
                "name": "Shaoqian Li",
                "org": ""
            }
        ],
        "venue": "IEEE Signal Process. Lett.",
        "year": 2012
    },
    "4kn2mcbU": {
        "id": "4kn2mcbU",
        "title": "Transmit Precoded Spatial Modulation: Maximizing the Minimum Euclidean Distance Versus Minimizing the Bit Error Ratio.",
        "abstract": "In this paper, we investigate a pair of transmit precoding (TPC)\u00a0algorithms conceived for spatial modulation (SM)\u00a0systems communicating over flat-fading multiple-input multiple-output (MIMO)\u00a0channels. In order to retain all the benefits of conventional SM, we design the TPC matrix to be diagonal and introduce two design criteria for optimizing the elements of the TPC matrix. Specifically, we first investigate a TPC design based on maximizing the minimum Euclidean distance   $d_{bf min }$   (max-  $d_{bf min }$  ) between the SM signal points at the receiver side. A closed-form solution of the optimal max-  $d_{bf min }$  -based TPC matrix is derived. Then, another TPC design algorithm is proposed for directly minimizing the bit error ratio (BER)\u00a0upper bound of SM, which is capable of jointly optimizing the overall Euclidean distance between all received signal points. In the minimum BER (min-BER)-based TPC algorithm, the theoretical gradient of the BER with respect to the diagonal TPC matrix is derived and a simplified iterative conjugate gradient (SCG)\u00a0algorithm is invoked for TPC optimization. Our simulation results demonstrate that the proposed max-  $d_{bf min }$  -based TPC algorithm is optimal in terms of the minimum distance. However, increasing   $d_{bf min }$   does not achieve a further BER improvement. We also confirm that the min-BER-based TPC outperforms the max-  $d_{bf min }$  -based TPC schemes in terms of the achievable BER performance.",
        "keywords": [],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Yong Liang Guan",
                "org": ""
            },
            {
                "name": "Yue Xiao",
                "org": ""
            },
            {
                "name": "Marco Di Renzo",
                "org": ""
            },
            {
                "name": "Shaoqian Li",
                "org": ""
            },
            {
                "name": "Lajos Hanzo",
                "org": ""
            }
        ],
        "venue": "IEEE Trans. Wireless Communications",
        "year": 2016
    },
    "3XcV3Ew0": {
        "id": "3XcV3Ew0",
        "title": "Spatial modulation for single carrier wireless transmission systems",
        "abstract": "Spatial Modulation (SM), is a new multiple antennas transmission technique for broadband wireless communications. In this paper, SM is firstly combined with single-carrier (SC) transmission systems for the merit of low peak average power ratio (PAPR) over conventional SM-orthogonal frequency division multiplexing (OFDM). Furthermore, for SM-SC systems, different detection techniques such as linear frequency-domain equalization (FDE) detection, decision feedback equalizer (DFE) detection and maximum likelihood detection (MLD) employing QR decomposition and M algorithm (QRM-MLD) techniques are explored to investigate the system performance. Finally, a comparison of the bit error rate (BER) performance between SM-SC and clipped SC-OFDM systems is given to show the merits of SM-SC systems.",
        "keywords": [],
        "authors": [
            {
                "name": "Bin Zhou",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, 610054, China"
            },
            {
                "name": "Yue Xiao",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, 610054, China"
            },
            {
                "name": "Ping Yang",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, 610054, China"
            },
            {
                "name": "Jin Wang",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, 610054, China"
            },
            {
                "name": "Shaoqian Li",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, 610054, China"
            }
        ],
        "venue": "CHINACOM",
        "year": 2011
    },
    "ckdFJjvx": {
        "id": "ckdFJjvx",
        "title": "Iterative Compensation for Clipping Noise in Spatial Modulation OFDM Systems.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yan Zhao",
                "org": ""
            },
            {
                "name": "Yue Xiao",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Shu Fang",
                "org": ""
            },
            {
                "name": "Wei Xiang",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Vehicular Technology",
        "year": 2019
    },
    "ZKhV9EzL": {
        "id": "ZKhV9EzL",
        "title": "Novel spatial modulation scheme based on transmit mode switching",
        "abstract": "A transmit mode switching (TMS) assisted adaptive spatial modulation (SM) scheme is proposed for multiple-input multiple-output (MIMO) transmission systems. The proposed scheme yields a performance bound with the aid of the nearest neighbor approximation. At a predefined spectral efficiency and transmit power target, the proposed scheme is capable of selecting the appropriate SM mode to minimize the conditioned pairwise error probability. Moreover, a simplified calculation method utilizing the special information transmission method of SM is proposed for mode selection. Simulation results show that the proposed scheme exhibits a better bit error ratio (BER) performance at low complexity cost compared with the conventional SM scheme, especially for the correlated MIMO channels.",
        "keywords": [
            "Adaptive modulation",
            "BER",
            "Detector",
            "MIMO",
            "Spatial modulation"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            },
            {
                "name": "Yi Yu",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            },
            {
                "name": "Yue Xiao",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            },
            {
                "name": "Shaoqian Li",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            },
            {
                "name": "Shaoqian Li",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            }
        ],
        "venue": "Dianzi Keji Daxue Xuebao/Journal of the University of Electronic Science and Technology of China",
        "year": 2013
    },
    "JbpE9zpy": {
        "id": "JbpE9zpy",
        "title": "Space-Time Block Coded Rectangular Differential Spatial Modulation.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Chaowu Wu",
                "org": ""
            },
            {
                "name": "Yue Xiao",
                "org": ""
            },
            {
                "name": "Lixia Xiao",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Xia Lei",
                "org": ""
            }
        ],
        "venue": "ICC",
        "year": 2018
    },
    "wZ4MHpzz": {
        "id": "wZ4MHpzz",
        "title": "Performance Analysis for the N-Continuous Precoded SM-OFDM System.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yue Xiao",
                "org": ""
            },
            {
                "name": "Feng Yu",
                "org": ""
            },
            {
                "name": "Xia Lei",
                "org": ""
            },
            {
                "name": "Dongxiao He",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Wei Xiang",
                "org": ""
            }
        ],
        "venue": "IEEE Trans. Vehicular Technology",
        "year": 2018
    },
    "GAFDTISl": {
        "id": "GAFDTISl",
        "title": "Adaptive Spatial Modulation for Wireless MIMO Transmission Systems",
        "abstract": "In this letter, an adaptive spatial modulation (ASM) transmission scheme is proposed to achieve better system performance under a fixed data rate. The proposed scheme is based on a developed modulation order selection criterion (MOSC), so as to minimize the conditioned pairwise error probability (PEP) for each channel realization. Furthermore, the special information-conveying mode of spatial modulation (SM) is utilized to reduce the complexity of the proposed algorithm. Simulation results show that the proposed adaptive SM scheme provides considerable system performance improvement compared to original SM system.",
        "keywords": [
            "Modulation",
            "Transmitting antennas",
            "MIMO",
            "Bit error rate",
            "Adaptive systems",
            "Receiving antennas"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Yue Xiao",
                "org": ""
            },
            {
                "name": "Yi Yu",
                "org": ""
            },
            {
                "name": "Shaoqian Li",
                "org": ""
            }
        ],
        "venue": "IEEE Communications Letters",
        "year": 2011
    },
    "EL879Oyf": {
        "id": "EL879Oyf",
        "title": "Simplified Adaptive Spatial Modulation for Limited-Feedback MIMO Systems",
        "abstract": "Adaptive spatial modulation (ASM), where the modulation orders assigned to transmit antennas are dynamically adapted to the changing channel conditions, is a new limited-feedback multiple-input-multiple-output (MIMO) transmission technique. However, the exhaustive search for the optimal modulation order vector in ASM requires very high computational complexity and feedback load. In this paper, we propose two simplified ASM (SASM) schemes that reduce the high computational complexity and feedback load with negligible performance loss. More specifically, a candidate-reduction-based ASM (CR-ASM) that exploits the candidate selection probability is first developed to shrink the search space. The CR-ASM scheme only considers the candidates with high probability. To further reduce the complexity, another SASM scheme that uses a one-bit reallocation (OBRA) algorithm for modulation order assignment is proposed. Regardless of the number of transmit antennas, OBRA only needs to consider the transmit antenna pair with the highest correlation and selects their optimum orders among four possible candidates, which significantly reduce the search complexity. Simulation results show that the proposed schemes substantially reduce computational cost and feedback load while maintaining the benefits of the conventional ASM, particularly for a high number of transmit antennas.",
        "keywords": [
            "Modulation",
            "Transmitting antennas",
            "Vectors",
            "Complexity theory",
            "MIMO",
            "Bit rate",
            "Channel estimation"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Yue Xiao",
                "org": ""
            },
            {
                "name": "Yi Yu",
                "org": ""
            },
            {
                "name": "Lei Li",
                "org": ""
            },
            {
                "name": "Qian Tang",
                "org": ""
            },
            {
                "name": "Shaoqian Li",
                "org": ""
            }
        ],
        "venue": "IEEE T. Vehicular Technology",
        "year": 2013
    },
    "AgwWmDua": {
        "id": "AgwWmDua",
        "title": "Single-RF and Twin-RF Spatial Modulation for an Arbitrary Number of Transmit Antennas.",
        "abstract": "Spatial modulation (SM) constitutes an appealing low-complexity single radio frequency (RF) aided multiple-input multiple-output technique. Conventional SM schemes tend to rely on transmit antenna (TA) configurations, where the number of TAs is a power of two. In order to circumvent this limitation, a novel single RF-aided SM conceived for an arbitrary number of TAs (SM-ATA) is proposed, which is then further developed to a twin-RF enhanced SM-ATA (ESM-ATA) schedule for exploiting the diversity advantage of space-time block coding. Furthermore, low-complexity near-optimal detectors are designed for both the SM-ATA and ESM-ATA schemes. Our simulation results show that the proposed SM-ATA schemes offer almost the same performance as conventional SM systems, despite using a reduced number of TAs at the same transmission rate. The proposed twin-RF ESM-ATA schemes provide a beneficial performance gain over the existing twin-RF multiplexing based and space-time coding based SM schemes. Finally, an upper bound is derived for the average bit error probability, which is confirmed by our simulation results.",
        "keywords": "",
        "authors": [
            {
                "name": "Lixia Xiao",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Yue Xiao",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Longfei You",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Ping Yang",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Shaoqian Li",
                "org": "National Key Laboratory of Science and Technology on Communications, University of Electronic Science and Technology of China, Chengdu, China"
            },
            {
                "name": "Lajos Hanzo",
                "org": "School of Electronics and Computer Science, University of Southampton, Southampton, U.K."
            }
        ],
        "venue": "IEEE Trans. Vehicular Technology",
        "year": 2018
    },
    "14vN5QGs": {
        "id": "14vN5QGs",
        "title": "Link Adaptation for Spatial Modulation With Limited Feedback",
        "abstract": "In this paper, link-adaptation schemes, where the transmit parameters are dynamically adapted to the changing channel conditions, are developed for spatial modulation (SM) transmission systems. The proposed schemes are based on the adaptive modulation (AM) and transmit-mode switching (TMS) techniques, to further exploit the spatial freedom of the multiple-input-multiple-output channel. More specifically, an optimal hybrid-SM (OH-SM) scheme that jointly uses both AM and TMS techniques is first developed to efficiently utilize the channel resources. In OH-SM, the transmit mode is jointly adapted with modulation orders according to the channel condition. Moreover, a suboptimal hybrid SM scheme, termed as a concatenated SM (C-SM) scheme, is also proposed. The C-SM scheme exploits the multistage adaptation strategy to balance the tradeoff between computational complexity and performance. The performance of the proposed schemes is evaluated by using the nearest neighbor approximations, to derive the parameter selection criterions. Simulation results show that, under the same spectral efficiency, the proposed schemes provide considerable system performance improvement compared with the conventional SM systems, particularly in correlated channel conditions.",
        "keywords": [
            "Modulation",
            "Transmitting antennas",
            "Bit error rate",
            "System performance",
            "Indexes",
            "Correlation",
            "MIMO"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Yue Xiao",
                "org": ""
            },
            {
                "name": "Lei Li",
                "org": ""
            },
            {
                "name": "Qian Tang",
                "org": ""
            },
            {
                "name": "Yi Yu",
                "org": ""
            },
            {
                "name": "Shaoqian Li",
                "org": ""
            }
        ],
        "venue": "IEEE T. Vehicular Technology",
        "year": 2012
    },
    "QdD8fPLe": {
        "id": "QdD8fPLe",
        "title": "On the radiative forcing of contrail cirrus contaminated by black carbon",
        "abstract": "",
        "keywords": [
            "radiative forcing"
        ],
        "authors": [
            {
                "name": "k n liou",
                "org": "university of california"
            },
            {
                "name": "y takano",
                "org": "university of california"
            },
            {
                "name": "qing yue",
                "org": "university of california"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            }
        ],
        "venue": "Geophysical Research Letters",
        "year": 2013
    },
    "vkHmhKkM": {
        "id": "vkHmhKkM",
        "title": "Improved Representation of Surface Spectral Emissivity in a Global Climate Model and Its Impact on Simulated Climate",
        "abstract": "AbstractSurface longwave emissivity can be less than unity and vary significantly with frequency. However, most climate models still assume a blackbody surface in the longwave (LW) radiation scheme of their atmosphere models. This study incorporates realistic surface spectral emissivity into the atmospheric component of the Community Earth System Model (CESM) version 1.1.1 and evaluates its impact on simulated climate. By ensuring consistency of the broadband surface longwave flux across different components of the CESM, the top of atmosphere (TOA) energy balance in the modified model can be attained without retuning the model. Inclusion of surface spectral emissivity, however, leads to a decrease of net upward longwave flux at the surface and a comparable increase of latent heat flux. Global-mean surface temperature difference between the modified and standard CESM simulation is 0.20 K for the fully coupled run and 0.45 K for the slab-ocean run. Noticeable surface temperature differences between the modi...",
        "keywords": "",
        "authors": [
            {
                "name": "Xianglei Huang",
                "org": "Department of Climate and Space Sciences and Engineering, University of Michigan, Ann Arbor, Michigan"
            },
            {
                "name": "Mark G. Flanner",
                "org": "Department of Climate and Space Sciences and Engineering, University of Michigan, Ann Arbor, Michigan"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, Texas"
            },
            {
                "name": "Daniel R. Feldman",
                "org": "Division of Climate and Ecosystem Sciences, Lawrence Berkeley Laboratory, Berkeley, California"
            },
            {
                "name": "Chaincy Kuo",
                "org": ""
            }
        ],
        "venue": "Journal of Climate",
        "year": 2018
    },
    "S5Rij1FV": {
        "id": "S5Rij1FV",
        "title": "A comparison of Aqua MODIS ice and liquid water cloud physical and optical properties between collection 6 and collection 5.1: Cloud radiative effects: Aqua MODIS C6-C51 Cloud Radiative Effect",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Bingqi Yi",
                "org": "Department of Atmospheric Sciences; Texas A&M University; Texas USA"
            },
            {
                "name": "Anita D. Rapp",
                "org": "Department of Atmospheric Sciences; Texas A&M University; Texas USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences; Texas A&M University; Texas USA"
            },
            {
                "name": "Bryan A. Baum",
                "org": "Space Science and Engineering Center; University of Wisconsin-Madison; Madison Wisconsin USA"
            },
            {
                "name": "Michael D. King",
                "org": "Department of Atmospheric Sciences; Texas A&M University; Texas USA"
            },
            {
                "name": "Michael D. King",
                "org": "Department of Atmospheric Sciences; Texas A&M University; Texas USA"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2017
    },
    "eOJSIZGa": {
        "id": "eOJSIZGa",
        "title": "Simulation of the global contrail radiative forcing: A sensitivity analysis",
        "abstract": "",
        "keywords": [
            "radiative forcing"
        ],
        "authors": [
            {
                "name": "bingqi yi",
                "org": "texas a m university"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "kuonan liou",
                "org": "university of california los angeles"
            },
            {
                "name": "patrick minnis",
                "org": "langley research center"
            },
            {
                "name": "joyce e penner",
                "org": "university of michigan"
            }
        ],
        "venue": "Geophysical Research Letters",
        "year": 2012
    },
    "AwcxPb8I": {
        "id": "AwcxPb8I",
        "title": "A Resampling-Based Stochastic Approximation Method for Analysis of Large Geostatistical Data",
        "abstract": "",
        "keywords": [
            "asymptotic normality",
            "u statistics"
        ],
        "authors": [
            {
                "name": "faming liang",
                "org": ""
            },
            {
                "name": "yichen cheng",
                "org": ""
            },
            {
                "name": "qifan song",
                "org": ""
            },
            {
                "name": "jincheol park",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            }
        ],
        "venue": "Journal of the American Statistical Association",
        "year": 2012
    },
    "aav0mTvR": {
        "id": "aav0mTvR",
        "title": "Ice cloud optical thickness, effective radius, and ice water path inferred from fused MISR and MODIS measurements based on a pixel\u2010level optimal ice particle roughness model",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yi Wang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, USA#TAB#"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, USA#TAB#"
            },
            {
                "name": "Souichiro Hioki",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, USA#TAB#"
            },
            {
                "name": "Michael D. King",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, USA"
            },
            {
                "name": "Bryan A. Baum",
                "org": "Science and Technology Corporation (STC) Madison WI USA"
            },
            {
                "name": "Larry Di Girolamo",
                "org": "Department of Atmospheric Sciences, University of Illinois at Urbana\u2010Champaign, Urbana, IL, USA"
            },
            {
                "name": "Dongwei Fu",
                "org": "Department of Atmospheric Sciences, University of Illinois at Urbana\u2010Champaign, Urbana, IL, USA"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2019
    },
    "7B9WU18R": {
        "id": "7B9WU18R",
        "title": "Optical properties of ice clouds: new modeling capabilities and relevant applications",
        "abstract": "",
        "keywords": [
            "optics",
            "remote sensing",
            "matrices",
            "scattering",
            "modeling",
            "crystals"
        ],
        "authors": [
            {
                "name": "lei bi",
                "org": "texas a m university"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "chao liu",
                "org": "texas a m university"
            },
            {
                "name": "bingqi yi",
                "org": "texas a m university"
            },
            {
                "name": "souichiro hioki",
                "org": "texas a m university"
            }
        ],
        "venue": "",
        "year": 2014
    },
    "aO98x6tv": {
        "id": "aO98x6tv",
        "title": "Side-Face Effect of a Dielectric Strip on Its Optical Properties",
        "abstract": "Light scattering by horizontally oriented platelike particles under normal incidence, such as ice plates or tree leaves under spaceborne lidar or radar waves, needs to be investigated for remote sensing of cirrus clouds or vegetation canopies. The solutions from the conventional geometrical ray tracing method for the scattering of electromagnetic waves by these particles are quite inaccurate because of the singularity problem that is inherent to this method. The scattering properties of large horizontally oriented platelike particles are usually approximated by using physical optics or electromagnetic wave theory while ignoring the side-face effect of the plates. In this paper, to examine the effect of side faces on light scattering by platelike particles, a 2-D finite-difference time-domain technique is applied to calculate light scattering by horizontally oriented ice and leaf strips under normal or quasi-normal incidence. It is found that for moderate-sized strips, the side faces of the particles scatter a significant amount of energy, resulting in strong maxima in the scattering phase function at certain scattering angles. By ignoring the effect of side faces, the scattering phase functions derived from electromagnetic wave theory have significant errors for small or moderate-sized strips. However, the ratio of the amount of energy scattered by the side faces to the total scattered energy decreases with the increase of strip width. When the size parameter of the strip is in the limit of geometric optics, the side-face effect is reduced to a negligible amount. However, even in this case, the polarization degrees from the approximation solutions of physical optics or electromagnetic wave theory ignoring the side-face effect still have large errors.",
        "keywords": [
            "side-face effect",
            "geophysical techniques",
            "remote sensing",
            "2d finite difference time-domain technique",
            "finite-difference time domain (fdtd)",
            "spaceborne lidar",
            "scattering",
            "light scattering",
            "ray tracing",
            "cirrus clouds",
            "strip",
            "strip.",
            "scattering phase function",
            "radar waves",
            "electromagnetic wave theory",
            "platelike particles",
            "ice",
            "dielectric strip effect",
            "scatter- ing",
            "vegetation canopies",
            "electromagnetic wave scattering",
            "finite difference time-domain analysis",
            "index terms\u2014finite-difference time domain fdtd",
            "ice plates",
            "tree leaves",
            "atmospheric boundary layer",
            "geometrical ray tracing method",
            "vegetation",
            "geometric optics",
            "electromagnetic waves",
            "finite difference time domain",
            "physical optics"
        ],
        "authors": [
            {
                "name": "Wenbo Sun",
                "org": ""
            },
            {
                "name": "Bing Lin",
                "org": ""
            },
            {
                "name": "Yongxiang Hu",
                "org": ""
            },
            {
                "name": "Zhenhui Wang",
                "org": ""
            },
            {
                "name": "Yunfei Fu",
                "org": ""
            },
            {
                "name": "Qian Feng",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            }
        ],
        "venue": "IEEE T. Geoscience and Remote Sensing",
        "year": 2008
    },
    "ACB6KESI": {
        "id": "ACB6KESI",
        "title": "Sensitivity study of ice crystal optical properties in the 874GHz submillimeter band",
        "abstract": "",
        "keywords": [
            "ice crystals"
        ],
        "authors": [
            {
                "name": "guanglin tang",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "d l wu",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2015
    },
    "IA7qzZeh": {
        "id": "IA7qzZeh",
        "title": "On the radiative properties of ice clouds: Light scattering, remote sensing, and radiation parameterization",
        "abstract": "Presented is a review of the radiative properties of ice clouds from three perspectives: light scattering simulations, remote sensing applications, and broadband radiation parameterizations appropriate for numerical models. On the subject of light scattering simulations, several classical computational approaches are reviewed, including the conventional geometric-optics method and its improved forms, the finite-difference time domain technique, the pseudo-spectral time domain technique, the discrete dipole approximation method, and the T-matrix method, with specific applications to the computation of the single-scattering properties of individual ice crystals. The strengths and weaknesses associated with each approach are discussed. With reference to remote sensing, operational retrieval algorithms are reviewed for retrieving cloud optical depth and effective particle size based on solar or thermal infrared (IR) bands. To illustrate the performance of the current solar- and IR-based retrievals, two case studies are presented based on spaceborne observations. The need for a more realistic ice cloud optical model to obtain spectrally consistent retrievals is demonstrated. Furthermore, to complement ice cloud property studies based on passive radiometric measurements, the advantage of incorporating lidar and/or polarimetric measurements is discussed. The performance of ice cloud models based on the use of different ice habits to represent ice particles is illustrated by comparing model results with satellite observations. A summary is provided of a number of parameterization schemes for ice cloud radiative properties that were developed for application to broadband radiative transfer submodels within general circulation models (GCMs). The availability of the single-scattering properties of complex ice habits has led to more accurate radiation parameterizations. In conclusion, the importance of using nonspherical ice particle models in GCM simulations for climate studies is proven.",
        "keywords": [
            "ice clouds",
            " light scattering",
            " remote sensing",
            " radiative property parameterization"
        ],
        "authors": [
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "kuonan liou",
                "org": "university of california"
            },
            {
                "name": "lei bi",
                "org": "texas a m university"
            },
            {
                "name": "chao liu",
                "org": "texas a m university"
            },
            {
                "name": "bingqi yi",
                "org": "texas a m university"
            },
            {
                "name": "bryan a baum",
                "org": "university of wisconsin madison"
            }
        ],
        "venue": "Advances in Atmospheric Sciences",
        "year": 2014
    },
    "9A9thJQf": {
        "id": "9A9thJQf",
        "title": "On the use of scattering kernels to calculate ice cloud bulk optical properties",
        "abstract": "Nonspherical ice crystal optical properties are of fundamental importance to atmospheric radiative transfer through an ice cloud and the remote sensing of its properties. In practice, the optical properties of individual ice crystals need to be integrated over particle size distributions to derive the bulk optical properties of ice clouds. Given a particle size distribution represented in terms of size bins, the conventional approach uses the microphysical and optical properties of ice crystals at the bin centers as approximations to the bin-averaged values. However, errors are incurred when the size bins are large. To reduce the potential errors, a kernel technique is utilized to calculate the bulk optical properties of ice clouds by computing the bin-averaged values instead of using the bin-center values. Comparisons between the solutions based on the conventional method and the kernel technique for different numbers of size bins from in situ measurements demonstrate that the results computed from the kernel technique are more accurate. The present study illustrates that, for a given size distribution, 40 or more size bins should be used to calculate the bulk optical properties of ice clouds by the conventional method. Although the accuracy of bulk-scattering properties can be improved by using fine bin resolutions in the single-scattering property computation, the advantage of using a precomputed database of scattering kernels allows efficient computation of ice cloud bulk optical properties without losing the accuracy. \u00a9 2012 American Meteorological Society.",
        "keywords": [
            "cloud retrieval",
            "optical properties",
            "radiative transfer"
        ],
        "authors": [
            {
                "name": "Xiaodong Liu",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "Shouguo Ding",
                "org": "Texas A and M University(Texas A and M University,Texas A&M Univ),College Station,United States"
            },
            {
                "name": "Lei Bi",
                "org": "Texas A and M University(Texas A and M University,Texas A&M Univ),College Station,United States"
            },
            {
                "name": "Ping Yang",
                "org": "Texas A and M University(Texas A and M University,Texas A&M Univ),College Station,United States"
            }
        ],
        "venue": "Journal of Atmospheric and Oceanic Technology",
        "year": 2012
    },
    "4yYeF7x4": {
        "id": "4yYeF7x4",
        "title": "Effect of mineral dust aerosol aspect ratio on polarized reflectance",
        "abstract": "",
        "keywords": [
            "aspect ratio",
            "satellite"
        ],
        "authors": [
            {
                "name": "xin huang",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "george w kattawar",
                "org": ""
            },
            {
                "name": "kuonan liou",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2015
    },
    "9PZz8qLH": {
        "id": "9PZz8qLH",
        "title": "The Microphysical Properties of Small Ice Particles Measured by the Small Ice Detector-3 Probe during the MACPEX Field Campaign",
        "abstract": "AbstractA reliable understanding of the microphysical properties of ice particles in atmospheric clouds is critical for assessing cloud radiative forcing effects in climate studies. Ice particle microphysical properties such as size, shape, and surface roughness all have substantial effects on the single-scattering characteristics of the particles. A recently developed ice particle probe, the Small Ice Detector-3 (SID-3), measures the two-dimensional near-forward light-scattering patterns of sampled ice particles. These scattering patterns provide a wealth of information for understanding the microphysical and radiative characteristics of ice particles. The SID-3 was operated successfully on 12 aircraft flights during the NASA Midlatitude Airborne Cirrus Properties Experiment (MACPEX) field campaign in April 2011. In this study, SID-3 measurements are used to investigate the frequency of occurrence of a number of ice particle properties observed during MACPEX. Individual scattering patterns (7.5\u00b0\u201323\u00b0) are...",
        "keywords": "",
        "authors": [
            {
                "name": "Carl Schmitt",
                "org": ""
            },
            {
                "name": "Martin Schnaiter",
                "org": ""
            },
            {
                "name": "Andrew J. Heymsfield",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Edwin Hirst",
                "org": ""
            },
            {
                "name": "Aaron Bansemer",
                "org": ""
            }
        ],
        "venue": "Journal of the Atmospheric Sciences",
        "year": 2016
    },
    "0SsKunTG": {
        "id": "0SsKunTG",
        "title": "Physical and optical properties of persistent contrails: Climatology and interpretation",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "hironobu iwabuchi",
                "org": "texas a m university"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "k n liou",
                "org": "university of california los angeles"
            },
            {
                "name": "patrick minnis",
                "org": "langley research center"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2012
    },
    "FCxitBgi": {
        "id": "FCxitBgi",
        "title": "A comparison of Aqua MODIS ice and liquid water cloud physical and optical properties between collection 6 and collection 5.1: Pixel-to-pixel comparisons: MODIS C6-C51 Cloud Property Differences",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Bingqi Yi",
                "org": "Department of Atmospheric Sciences; Texas A&M University; College Station Texas USA"
            },
            {
                "name": "Anita D. Rapp",
                "org": "Department of Atmospheric Sciences; Texas A&M University; College Station Texas USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences; Texas A&M University; College Station Texas USA"
            },
            {
                "name": "Bryan A. Baum",
                "org": "Space Science and Engineering Center; University of Wisconsin-Madison; Madison Wisconsin USA"
            },
            {
                "name": "Michael D. King",
                "org": "Department of Atmospheric Sciences; Texas A&M University; College Station Texas USA"
            },
            {
                "name": "Michael D. King",
                "org": "Department of Atmospheric Sciences; Texas A&M University; College Station Texas USA"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2017
    },
    "zSohRPXc": {
        "id": "zSohRPXc",
        "title": "Sensitivity of depolarized lidar signals to cloud and aerosol particle properties",
        "abstract": "Measurements from depolarized lidars provide a promising method to retrieve both cloud and aerosol properties and a versatile complement to passive satellite-based sensors. For lidar observations of clouds and aerosols, multiple scattering plays an important role in the scattering process. Monte Carlo simulations are carried out to investigate the sensitivity of lidar backscattering depolarization to cloud and aerosol properties. Lidar parameters are chosen to be similar to those of the upcoming space-based CALIPSO lidar. Cases are considered that consist of a single cloud or aerosol layer, as well as a case in which cirrus clouds overlay different types of aerosols. It is demonstrated that besides thermodynamic cloud phase, the depolarized lidar signal may provide additional information on ice or aerosol particle shapes. However, our results show little sensitivity to ice or aerosol particle sizes. Additionally, for the case of multiple but overlapping layers involving both clouds and aerosols, the depolarized lidar contains information that can help identify the particle properties of each layer.",
        "keywords": [
            "clouds",
            "space-borne lidar",
            "particle shape",
            "calipso",
            "depolarization",
            "monte carlo simulation",
            "thermodynamics",
            "particle size"
        ],
        "authors": [
            {
                "name": "Yu You",
                "org": ""
            },
            {
                "name": "George W. Kattawar",
                "org": "Department of Physics, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Yong X. Hu",
                "org": "NASA Langley Research Center, Hampton, VA 23681, USA"
            },
            {
                "name": "Bryan A. Baum",
                "org": "NASA Langley Research Center, Hampton, VA 23681, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy and Radiative Transfer",
        "year": 2006
    },
    "x4TnVKmP": {
        "id": "x4TnVKmP",
        "title": "Parameterization of contrail radiative properties for climate studies: CONTRAIL PARAMETERIZATION",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yu xie",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "kuonan liou",
                "org": ""
            },
            {
                "name": "patrick minnis",
                "org": ""
            },
            {
                "name": "david p duda",
                "org": ""
            }
        ],
        "venue": "Geophysical Research Letters",
        "year": 2012
    },
    "UMdDh1Ek": {
        "id": "UMdDh1Ek",
        "title": "Effect of Thin Cirrus Clouds on Dust Optical Depth Retrievals From MODIS Observations.",
        "abstract": "",
        "keywords": [
            "radiative transfer",
            "optical scattering",
            "crystals",
            "radiative transfer model",
            "atmospheric chemistry",
            "radiometry",
            "optical sensor",
            "atmospheric modeling",
            "spectral reflectance",
            "rayleigh scattering",
            "remote sensing",
            "atmospheric optics",
            "lookup table",
            "optical depth",
            "mineral dust",
            "albedo"
        ],
        "authors": [
            {
                "name": "Qian Feng",
                "org": ""
            },
            {
                "name": "N. Christina Hsu",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Si-Chee Tsay",
                "org": ""
            }
        ],
        "venue": "IEEE T. Geoscience and Remote Sensing",
        "year": 2011
    },
    "OMsnSSa4": {
        "id": "OMsnSSa4",
        "title": "Bulk Scattering Properties for the Remote Sensing of Ice Clouds. Part I: Microphysical Data and Models",
        "abstract": "This study reports on the use of in situ data obtained in midlatitude and tropical ice clouds from airborne sampling probes and balloon-borne replicators as the basis for the development of bulk scattering models for use in satellite remote sensing applications. Airborne sampling instrumentation includes the two- dimensional cloud (2D-C), two-dimensional precipitation (2D-P), high-volume precipitation spectrometer (HVPS), cloud particle imager (CPI), and NCAR video ice particle sampler (VIPS) probes. Herein the development of a comprehensive set of microphysical models based on in situ measurements of particle size distributions (PSDs) is discussed. Two parameters are developed and examined: ice water content (IWC) and median mass diameter Dm. Comparisons are provided between the IWC and Dm values derived from in situ measurements obtained during a series of field campaigns held in the midlatitude and tropical regions and those calculated from a set of modeled ice particles used for light-scattering calculations. The ice particle types considered in this study include droxtals, hexagonal plates, solid columns, hollow columns, aggregates, and 3D bullet rosettes. It is shown that no single habit accurately replicates the derived IWC and Dm values, but a mixture of habits can significantly improve the comparison of these bulk microphysical properties. In addition, the relationship between Dm and the effective particle size Deff, defined as 1.5 times the ratio of ice particle volume to projected area for a given PSD, is investigated. Based on these results, a subset of microphysical models is chosen as the basis for the development of ice cloud bulk scattering models in Part II of this study.",
        "keywords": [],
        "authors": [
            {
                "name": "Bryan A. Baum",
                "org": ""
            },
            {
                "name": "Andrew J. Heymsfield",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Sarah T. Bedka",
                "org": ""
            }
        ],
        "venue": "Journal of Applied Meteorology",
        "year": 2005
    },
    "wsE5UZw4": {
        "id": "wsE5UZw4",
        "title": "Impact of radiatively interactive dust aerosols in the NASA GEOS-5 climate model: Sensitivity to dust particle shape and refractive index: MODELING DUST TRANSPORT AND OPTICS",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "peter richard colarco",
                "org": ""
            },
            {
                "name": "e nowottnick",
                "org": ""
            },
            {
                "name": "c a randles",
                "org": ""
            },
            {
                "name": "bingqi yi",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "kyumyong kim",
                "org": ""
            },
            {
                "name": "jamison a smith",
                "org": ""
            },
            {
                "name": "charles gaylord bardeen",
                "org": ""
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2014
    },
    "cu1yfEKh": {
        "id": "cu1yfEKh",
        "title": "Ice particle morphology and microphysical properties of transparent cirrus clouds inferred from CALIOP\u2013IIR measurements",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Masanori Saito",
                "org": ""
            },
            {
                "name": "Hironobu Iwabuchi",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Guanglin Tang",
                "org": ""
            },
            {
                "name": "Michael D King",
                "org": ""
            },
            {
                "name": "Miho Sekiguchi",
                "org": ""
            }
        ],
        "venue": "Japan Geoscience Union",
        "year": 2017
    },
    "qMXsEDC3": {
        "id": "qMXsEDC3",
        "title": "Inference and Validation of Cloud Phase from MODIS, AIRS and CALIPSO Data",
        "abstract": "",
        "keywords": [
            "atmospheric scattering",
            "scattering"
        ],
        "authors": [
            {
                "name": "bryan a baum",
                "org": ""
            },
            {
                "name": "robert e holz",
                "org": ""
            },
            {
                "name": "hunglung huang",
                "org": ""
            },
            {
                "name": "yongkeun lee",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "shaima l nasiri",
                "org": ""
            },
            {
                "name": "michael d king",
                "org": ""
            },
            {
                "name": "steve platnick",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2007
    },
    "wmvuBd67": {
        "id": "wmvuBd67",
        "title": "Effects of ice particle size vertical inhomogeneity on the passive remote sensing of ice clouds",
        "abstract": "The solar reflectance bi-spectral (SRBS) and infrared split-window (IRSpW) methods are two of the most popular techniques for passive ice cloud property retrievals from multispectral imagers. Ice clouds are usually assumed to be vertically homogeneous in global operational algorithms based on these methods, although significant vertical variations of ice particle size are typically observed in ice clouds. In this study we investigate uncertainties in retrieved optical thickness, effective particle size, and ice water path introduced by a homogeneous cloud assumption in both the SRBS and IRSpW methods, and focus on whether the assumption can lead to significant discrepancies between the two methods. The study simulates the upwelling spectral radiance associated with vertically structured clouds and passes the results through representative SRBS and IRSpW retrieval algorithms. Cloud optical thickness is limited to values for which IRSpW retrievals are possible (optical thickness less than about 7). When the ice cloud is optically thin and yet has a significant ice particle size vertical variation, it is found that both methods tend to underestimate the effective radius and ice water path. The reason for the underestimation is the nonlinear dependence of ice particle scattering properties (extinction and single scattering albedo) on the effective radius. Because the nonlinearity effect is stronger in the IRSpW than the SRBS method, the IRSpW-based IWP tends to be smaller than the SRBS counterpart. When the ice cloud is moderately optically thick, the IRSpW method is relatively insensitive to cloud vertical structure and effective radius retrieval is weighted toward smaller ice particle size, while the weighting function makes the SRBS method more sensitive to the ice particle size in the upper portion of the cloud. As a result, when ice particle size increases monotonically toward cloud base, the two methods are in qualitative agreement; in the event that ice particle size decreases toward cloud base, the effective radius and ice water path retrievals based on the SRBS method are substantially larger than those from the IRSpW. The main findings of this study suggest that the homogenous cloud assumption can affect the SRBS and IRSpW methods to different extents and, consequently, can lead to significantly different retrievals. Therefore caution should be taken when comparing and combining the ice cloud property retrievals from these two methods.",
        "keywords": [
            "vertical inhomogeneity",
            "ice cloud",
            "visible",
            "infrared",
            "modis",
            "passive remote sensing",
            "algorithms",
            "mathematical models",
            "optical thickness",
            "albedo",
            "reflectance",
            "weight function",
            "remote sensing",
            "multispectral images",
            "particle size",
            "particle size distribution",
            "environmental sciences"
        ],
        "authors": [
            {
                "name": "Zhibo Zhang",
                "org": "Goddard Earth Science and Technology Center, University of Maryland, Baltimore County, Baltimore, Maryland, USA"
            },
            {
                "name": "Steven Platnick",
                "org": "Laboratory for Atmospheres, NASA Goddard Space Flight Center, Greenbelt, Maryland, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&amp;M University, College Station, Texas, USA"
            },
            {
                "name": "Andrew K. Heidinger",
                "org": "Center for Satellite Applications and Research, NOAA National Environmental Satellite, Data, and Information Service, Madison, Wisconsin, USA"
            },
            {
                "name": "Jennifer M. Comstock",
                "org": "Pacific Northwest National Laboratory, Richland, Washington, USA"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2010
    },
    "z1fjWrsM": {
        "id": "z1fjWrsM",
        "title": "Simulation of the color ratio associated with the backscattering of radiation by ice particles at the wavelengths of 0.532 and 1.064 \u03bcm",
        "abstract": "This study explores a simulation of ice cloud optical properties similar to those observed using the Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP), a dual-wavelength (0.532 and 1.064 \u03bcm) lidar. The goal is to better understand the sensitivity of the color ratio (the ratio of the backscatter coefficients at the wavelengths of 1.064 and 0.532 \u03bcm) to ice particle habit. The single-scattering properties of randomly oriented hexagonal ice particles are simulated from the finite difference time domain (FDTD) method for particles with size parameters less than 50, and from an improved geometric optics method (IGOM) for particles with larger size parameters (a quantity proportional to the ratio of the particle characteristic dimension to the incident wavelength). Based on the assumption that ice particles are hexagonal particles, the color ratio values are found to be less than unity with a peak value near 0.7 for columns and 0.8 for plates. If spherical ice particles are assumed, the color ratio values can be larger than unity and may even approach 2 for many size distributions. The deviation in the value of the color ratio from unity is due to different distributions of size parameters for the two wavelengths, and to smaller single-scattering albedo values for large particles at 1.064 \u03bcm than at 0.532 \u03bcm. The present simulations of the color ratio for hexagonal columns are qualitatively consistent with measurements from a ground-based lidar, located at Hampton University in Hampton, Virginia, which peak near 0.88, but the two results differ quantitatively by 10\u201320 percent.",
        "keywords": [
            "ice crystals",
            "lidar color ratio",
            "calipso",
            "geometric optics",
            "finite difference time domain"
        ],
        "authors": [
            {
                "name": "Lei Bi",
                "org": "Department of Physics and Institute for Quantum Studies, Texas A&amp;M University, College Station, Texas, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&amp;M University, College Station, Texas, USA"
            },
            {
                "name": "George W. Kattawar",
                "org": "Department of Physics and Institute for Quantum Studies, Texas A&amp;M University, College Station, Texas, USA"
            },
            {
                "name": "Bryan A. Baum",
                "org": "Space Science and Engineering Center, University of Wisconsin-Madison, Madison, Wisconsin, USA"
            },
            {
                "name": "Yong X. Hu",
                "org": "NASA Langley Research Center, Hampton, Virginia, USA"
            },
            {
                "name": "David M. Winker",
                "org": "NASA Langley Research Center, Hampton, Virginia, USA"
            },
            {
                "name": "R. Scott Brock",
                "org": "Department of Physics, East Carolina University, Greenville, North Carolina, USA"
            },
            {
                "name": "Jun Q. Lu",
                "org": "Department of Physics, East Carolina University, Greenville, North Carolina, USA"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2009
    },
    "yYpsbLDm": {
        "id": "yYpsbLDm",
        "title": "FDTD solutions for the distribution of radiation from dipoles embedded in dielectric particles",
        "abstract": "The finite-difference time-domain (FDTD) method is used to simulate the electromagnetic radiation emitted by an infinitesimal electric dipole embedded in a small particle with an arbitrary shape and internal composition. The far-field pattern of the radiation pertaining to dipoles embedded in a host particle is highly sensitive to the particle shape. Thus, it is possible to discriminate host particles according to their radiation patterns. The method reported here is also applicable to the study of induced Raman scattering and fluorescence phenomena and the detection of biological agents.",
        "keywords": [
            "non-spherical particle",
            "electric dipole radiation",
            "finite-difference time-domain method",
            "raman scattering",
            "electromagnetic radiation",
            "radiation pattern",
            "finite difference time domain"
        ],
        "authors": [
            {
                "name": "Changhui Li",
                "org": ""
            },
            {
                "name": "George W. Kattawar",
                "org": "Department of Physics, Texas A&M University, College Station, TX, USA"
            },
            {
                "name": "Yu You",
                "org": "Department of Physics, Texas A&M University, College Station, TX, USA"
            },
            {
                "name": "Pengwang Zhai",
                "org": "Department of Physics, Texas A&M University, College Station, TX, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy and Radiative Transfer",
        "year": 2007
    },
    "hD2v7Yus": {
        "id": "hD2v7Yus",
        "title": "Test of the Fixed Anvil Temperature Hypothesis",
        "abstract": "",
        "keywords": [
            "climate change"
        ],
        "authors": [
            {
                "name": "yue li",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "gerald r north",
                "org": ""
            },
            {
                "name": "a e dessler",
                "org": ""
            }
        ],
        "venue": "Journal of the Atmospheric Sciences",
        "year": 2012
    },
    "xINqNjWr": {
        "id": "xINqNjWr",
        "title": "High Cloud Properties from Three Years of MODIS<i>Terra</i>and<i>Aqua</i>Collection-4 Data over the Tropics",
        "abstract": "This study surveys the optical and microphysical properties of high (ice) clouds over the Tropics (30\u00b0S- 30\u00b0N) over a 3-yr period from September 2002 through August 2005. The analyses are based on the gridded level-3 cloud products derived from the measurements acquired by the Moderate Resolution Imaging Spectroradiometer (MODIS) instruments aboard both the NASA Earth Observing System Terra and Aqua platforms. The present analysis is based on the MODIS collection-4 data products. The cloud products provide daily, weekly, and monthly mean cloud fraction, cloud optical thickness, cloud effective radius, cloud-top temperature, cloud-top pressure, and cloud effective emissivity, which is defined as the product of cloud emittance and cloud fraction. This study is focused on high-level ice clouds. The MODIS-derived high clouds are classified as cirriform and deep convective clouds using the International Satellite Cloud Climatology Project (ISCCP) classification scheme. Cirriform clouds make up more than 80% of the total high clouds, whereas deep convective clouds account for less than 20% of the total high clouds. High clouds are prevalent over the intertropical convergence zone (ITCZ), the South Pacific convergence zone (SPCZ), tropical Africa, the Indian Ocean, tropical America, and South America. Moreover, land-ocean, morning- afternoon, and summer-winter variations of high cloud properties are also observed.",
        "keywords": [
            "international satellite cloud climatology project"
        ],
        "authors": [
            {
                "name": "Gang Hong",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Bo-Cai Gao",
                "org": ""
            },
            {
                "name": "Bryan A. Baum",
                "org": ""
            },
            {
                "name": "Yong X. Hu",
                "org": ""
            },
            {
                "name": "Michael D. King",
                "org": ""
            },
            {
                "name": "Steven Platnick",
                "org": ""
            }
        ],
        "venue": "Journal of Applied Meteorology and Climatology",
        "year": 2007
    },
    "6N5c3CRk": {
        "id": "6N5c3CRk",
        "title": "Improvement of the Simulation of Cloud Longwave Scattering in Broadband Radiative Transfer Models",
        "abstract": "AbstractCloud longwave scattering is generally neglected in general circulation models (GCMs), but it plays a significant and highly uncertain role in the atmospheric energy budget as demonstrated in recent studies. To reduce the errors due to neglecting cloud longwave scattering, two new radiance adjustment methods are developed that retain the computational efficiency of broadband radiative transfer simulations. In particular, two existing scaling methods and the two new adjustment methods are implemented in the Rapid Radiative Transfer Model (RRTM). The results are then compared with those based on the Discrete Ordinates Radiative Transfer (DISORT) method that explicitly accounts for multiple scattering by clouds. The two scaling methods are shown to improve the accuracy of radiative transfer simulations for optically thin clouds but not effectively for optically thick clouds. However, the adjustment methods reduce computational errors over a wide range from optically thin to thick clouds. With the adj...",
        "keywords": "",
        "authors": [
            {
                "name": "Guanglin Tang",
                "org": " Department of Atmospheric Sciences, Texas A&M University, College Station, Texas"
            },
            {
                "name": "Ping Yang",
                "org": " Department of Atmospheric Sciences, Texas A&M University, College Station, Texas"
            },
            {
                "name": "George W. Kattawar",
                "org": " Department of Physics and Astronomy, Texas A&M University, College Station, Texas"
            },
            {
                "name": "Xianglei Huang",
                "org": " Department of Climate and Space Sciences and Engineering, University of Michigan, Ann Arbor, Michigan"
            },
            {
                "name": "Eli J. Mlawer",
                "org": " Atmospheric and Environmental Research, Inc., Cambridge, Massachusetts"
            },
            {
                "name": "Bryan A. Baum",
                "org": ""
            },
            {
                "name": "Michael D. King",
                "org": " Department of Atmospheric Sciences, Texas A&M University, College Station, Texas"
            },
            {
                "name": "Michael D. King",
                "org": " Department of Atmospheric Sciences, Texas A&M University, College Station, Texas"
            }
        ],
        "venue": "Journal of the Atmospheric Sciences",
        "year": 2018
    },
    "YxumCak3": {
        "id": "YxumCak3",
        "title": "Simulations of Infrared Radiances over a Deep Convective Cloud System Observed during TC4: Potential for Enhancing Nocturnal Ice Cloud Retrievals",
        "abstract": "",
        "keywords": [
            "brightness temperature",
            "satellite",
            "data retrieval",
            "climate",
            "particle size",
            "convection",
            "optical depth",
            "optical thickness",
            "tropical regions"
        ],
        "authors": [
            {
                "name": "patrick minnis",
                "org": ""
            },
            {
                "name": "gang hong",
                "org": ""
            },
            {
                "name": "j kirk ayers",
                "org": ""
            },
            {
                "name": "william l smith",
                "org": ""
            },
            {
                "name": "christopher r yost",
                "org": ""
            },
            {
                "name": "andrew j heymsfield",
                "org": ""
            },
            {
                "name": "gerald m heymsfield",
                "org": ""
            },
            {
                "name": "dennis l hlavka",
                "org": ""
            },
            {
                "name": "michael d king",
                "org": ""
            },
            {
                "name": "errol korn",
                "org": ""
            },
            {
                "name": "matthew mcgill",
                "org": ""
            },
            {
                "name": "henry b selkirk",
                "org": ""
            },
            {
                "name": "anne m thompson",
                "org": ""
            },
            {
                "name": "lin tian",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            }
        ],
        "venue": "Remote Sensing",
        "year": 2012
    },
    "EYG6VUEB": {
        "id": "EYG6VUEB",
        "title": "Some New Progresses in the Optical Properties of Nonspherical Ice Crystals and Dust Aerosols",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "lei bi",
                "org": ""
            },
            {
                "name": "zhaokai meng",
                "org": ""
            },
            {
                "name": "george w kattawar",
                "org": ""
            },
            {
                "name": "bryan a baum",
                "org": ""
            },
            {
                "name": "hunglung huang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2009
    },
    "dnttnmqC": {
        "id": "dnttnmqC",
        "title": "Temperature dependence of ice optical constants: Implications for simulating the single-scattering properties of cold ice clouds",
        "abstract": "",
        "keywords": [
            "refractive index",
            "kramers kronig",
            "remote sensing",
            "infrared",
            "kramers kronig relations",
            "spectrum"
        ],
        "authors": [
            {
                "name": "hironobu iwabuchi",
                "org": "tohoku university"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2011
    },
    "ZmWXoUmf": {
        "id": "ZmWXoUmf",
        "title": "A regional, size-dependent, and causal effective medium model for Asian and Saharan mineral dust refractive index spectra",
        "abstract": "Abstract   A model is developed for the refractive index spectra of desert mineral dust. This model is applicable regionally to both Asian and Saharan dust as the largest global aerosol sources. The capability of the model further aims at representing important local features through a subdivision into northern and southern Sahara, as well as western and eastern Asia. Machine learning techniques for accelerated literature data acquisition are presented. Available refractive index spectra for individual minerals and chemical species are combined based on the Bruggeman effective medium formula. A numerical procedure for effectively solving the resulting higher-order polynomial expression is presented. The present results of the effective refractive indices are validated through the Kramers-Kronig relation; in particular, a Hilbert transform is applied to the imaginary part of the refractive index spectra.",
        "keywords": "",
        "authors": [
            {
                "name": "Patrick G. Stegmann",
                "org": "Department of Atmospheric Sciences, Texas A&M University, 3150 TAMU, 77840 College Station, TX, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, 3150 TAMU, 77840 College Station, TX, USA"
            }
        ],
        "venue": "Journal of Aerosol Science",
        "year": 2017
    },
    "4a90GFsE": {
        "id": "4a90GFsE",
        "title": "Remote Sensing of Liquid Water and Ice Cloud Optical Thickness and Effective Radius in the Arctic: Application of Airborne Multispectral MAS Data",
        "abstract": "A multispectral scanning spectrometer was used to obtain measurements of the bidirectional reflectance and brightness temperature of clouds, sea ice, snow, and tundra surfaces at 50 discrete wavelengths between 0.47 and 14.0 mm. These observations were obtained from the NASA ER-2 aircraft as part of the First ISCCP (International Satellite Cloud Climatology Project) Regional Experiment (FIRE) Arctic Clouds Experiment, conducted over a 1600 km 3 500 km region of the north slope of Alaska and surrounding Beaufort and Chukchi Seas between 18 May and 6 June 1998. Multispectral images in eight distinct bands of the Moderate Resolution Imaging Spectroradiometer (MODIS) Airborne Simulator (MAS) were used to derive a confidence in clear sky (or alternatively the probability of cloud) over five different ecosystems. Based on the results of individual tests run as part of this cloud mask, an algorithm was developed to estimate the phase of the clouds (liquid water, ice, or undetermined phase). Finally, the cloud optical thickness and effective radius were derived for both water and ice clouds that were detected during one flight line on 4 June. This analysis shows that the cloud mask developed for operational use on MODIS, and tested using MAS data in Alaska, is quite capable of distinguishing clouds from bright sea ice surfaces during daytime conditions in the high Arctic. Results of individual tests, however, make it difficult to distinguish ice clouds over snow and sea ice surfaces, so additional tests were added to enhance the confidence in the thermodynamic phase of clouds over the Chukchi Sea. The cloud optical thickness and effective radius retrievals used three distinct bands of the MAS, with a recently developed 1.62- and 2.13-mm-band algorithm being used quite successfully over snow and sea ice surfaces. These results are contrasted with a MODIS-based algorithm that relies on spectral reflectance at 0.87 and 2.13 mm.",
        "keywords": [
            "brightness temperature",
            "international satellite cloud climatology project",
            "multispectral images",
            "remote sensing",
            "snow",
            "spectral reflectance",
            "optical thickness",
            "tundra",
            "thermodynamics",
            "sea ice",
            "reflectance"
        ],
        "authors": [
            {
                "name": "Michael D. King",
                "org": ""
            },
            {
                "name": "Steven Platnick",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "G. Thomas Arnold",
                "org": ""
            },
            {
                "name": "Mark A. Gray",
                "org": ""
            },
            {
                "name": "J\u00e9r\u00f4me C. Riedi",
                "org": ""
            },
            {
                "name": "Steven A. Ackerman",
                "org": ""
            },
            {
                "name": "Kuo-Nan Liou",
                "org": ""
            }
        ],
        "venue": "Journal of Atmospheric and Oceanic Technology",
        "year": 2004
    },
    "rqDAYx83": {
        "id": "rqDAYx83",
        "title": "Observations and modeling of ice cloud shortwave spectral albedo during the Tropical Composition, Cloud and Climate Coupling Experiment (TC4)",
        "abstract": "Ice cloud optical thickness and effective radius have been retrieved from hyperspectral irradiance and discrete spectral radiance measurements for four ice cloud cases during the Tropical Composition, Cloud and Climate Coupling Experiment (TC4) over a range of solar zenith angle (23\u00b0\u201353\u00b0) and high (46\u201390) and low (5\u201315) optical thicknesses. The retrieved optical thickness and effective radius using measurements at only two wavelengths from the Solar Spectral Flux Radiometer (SSFR) irradiance and the Moderate Resolution Imaging Spectroradiometer Airborne Simulator (MAS) were input to a radiative transfer model using two libraries of ice crystal single-scattering optical properties to reproduce spectral albedo over the spectral range from 400 to 2130 nm. The two commonly used ice single-scattering models were evaluated by examining the residuals between observed spectral and predicted spectral albedo. The SSFR and MAS retrieved optical thickness and effective radius were found to be in close agreement for the low to moderately optically thick clouds with a mean difference of 3.42 in optical thickness (SSFR lower relative to MAS) and 3.79 \u03bcm in effective radius (MAS smaller relative to SSFR). The higher optical thickness case exhibited a larger difference in optical thickness (40.5) but nearly identical results for effective radius. The single-scattering libraries were capable of reproducing the spectral albedo in most cases examined to better than 0.05 for all wavelengths. Systematic differences between the model and measurements increased with increasing optical thickness and approached 0.10 between 400 and 600 nm and selected wavelengths between 1200 and 1300 nm. Differences between radiance and irradiance based retrievals of optical thickness and effective radius error sources in the modeling of ice single-scattering properties are examined.",
        "keywords": [
            "albedo",
            "cirrus",
            "hyperspectral",
            "radiative transfer model"
        ],
        "authors": [
            {
                "name": "Bruce C. Kindel",
                "org": "Laboratory for Atmospheric and Space Physics, Department of Atmospheric and Oceanic Sciences, University of Colorado at Boulder, Boulder, Colorado, USA"
            },
            {
                "name": "K. Sebastian Schmidt",
                "org": "Department of Atmospheric and Oceanic Sciences, University of Colorado at Boulder, Boulder, Colorado, USA"
            },
            {
                "name": "Peter Pilewskie",
                "org": "Laboratory for Atmospheric and Space Physics, Department of Atmospheric and Oceanic Sciences, University of Colorado at Boulder, Boulder, Colorado, USA"
            },
            {
                "name": "Bryan A. Baum",
                "org": "Space Science and Engineering Center, University of Wisconsin-Madison, Madison, Wisconsin, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&amp;M University, College Station, Texas, USA"
            },
            {
                "name": "Steven Platnick",
                "org": "NASA Goddard Space Flight Center, Greenbelt, Maryland, USA"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2010
    },
    "80R7CV6N": {
        "id": "80R7CV6N",
        "title": "Global distribution of instantaneous daytime radiative effects of high thin clouds observed by the cloud profiling radar",
        "abstract": "",
        "keywords": [
            "radar",
            "profiling"
        ],
        "authors": [
            {
                "name": "yongkeun lee",
                "org": "university of wisconsin madison"
            },
            {
                "name": "thomas j greenwald",
                "org": "university of wisconsin madison"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "steve ackerman",
                "org": "university of wisconsin madison"
            },
            {
                "name": "hunglung huang",
                "org": "university of wisconsin madison"
            }
        ],
        "venue": "Journal of Applied Remote Sensing",
        "year": 2010
    },
    "lquG8b8z": {
        "id": "lquG8b8z",
        "title": "Inhomogeneity structure and the applicability of effective medium approximations in calculating light scattering by inhomogeneous particles",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "chao liu",
                "org": ""
            },
            {
                "name": "r lee panetta",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2014
    },
    "eHvyYmQs": {
        "id": "eHvyYmQs",
        "title": "The Sensitivity of Ice Cloud Optical and Microphysical Passive Satellite Retrievals to Cloud Geometrical Thickness",
        "abstract": "Most satellite-based ice cloud retrieval algorithms rely on precomputed lookup libraries for inferring the ice cloud optical thickness (\u03c4) and effective particle size (De). However, this retrieval methodology does not account for the case where cloud geometrical thickness may vary by several kilometers. In this paper, we investigate the effect of the ice cloud geometrical thickness on the retrieval of \u03c4 and De for algorithms using the Moderate Resolution Imaging Spectroradiometer infrared (IR) bands at 8.5 and 11 \u00b5m (or 12 \u00b5m) or solar bands at 0.65 and 1.64 \u00b5m (or 2.13 \u00b5m). We use a rigorous radiative transfer package to simulate the IR brightness temperatures and solar reflectances, assuming that the ice cloud top height is fixed at 12 or 15 km with a variation of cloud geometrical thickness from 0.5 to 5 km. The simulated brightness temperatures and reflectances are then used to investigate the errors of cloud \u03c4 and De inferred from the precomputed lookup tables developed with a specific geo- metrical thickness. It is found that the retrieval errors in \u03c4 and De increase with increasing \u03c4 for the IR and solar methods. In both cases, cloud \u03c4 and De may be underestimated and overestimated, respectively, if the effect of the cloud geometrical thickness is not taken into account. The effect of the cloud geometrical thickness on the retrieval of cloud optical and microphysical properties is much larger for the IR algorithm than for the solar-band-based algorithm. This paper demonstrates that the inclusion of the information about the cloud geometrical thickness may improve the accuracy of the retrieval of the cloud properties on the basis of the precomputed lookup libraries. Index Terms\u2014Geometrical thickness, ice cloud, Moderate Resolution Imaging Spectroradiometer (MODIS), remote sensing.",
        "keywords": [
            "solid modeling",
            "image retrieval",
            "atmospheric optics",
            "remote sensing",
            "geometrical optics",
            "lookup table",
            "radiative transfer",
            "particle size",
            "satellites",
            "infrared",
            "brightness temperature"
        ],
        "authors": [
            {
                "name": "Gang Hong",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Hung-Lung Huang",
                "org": ""
            },
            {
                "name": "Bryan A. Baum",
                "org": ""
            },
            {
                "name": "Yongxiang Hu",
                "org": ""
            },
            {
                "name": "Steven Platnick",
                "org": ""
            }
        ],
        "venue": "IEEE T. Geoscience and Remote Sensing",
        "year": 2007
    },
    "6aI1Ra11": {
        "id": "6aI1Ra11",
        "title": "AERONET-Based Nonspherical Dust Optical Models and Effects on the VIIRS Deep Blue/SOAR Over Water Aerosol Product: Dust Optical Models for Deep Blue/SOAR",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jaehwa Lee",
                "org": "NASA Goddard Space Flight Center; Greenbelt MD USA"
            },
            {
                "name": "Jaehwa Lee",
                "org": "NASA Goddard Space Flight Center; Greenbelt MD USA"
            },
            {
                "name": "Andrew M. Sayer",
                "org": "NASA Goddard Space Flight Center; Greenbelt MD USA"
            },
            {
                "name": "Andrew M. Sayer",
                "org": "NASA Goddard Space Flight Center; Greenbelt MD USA"
            },
            {
                "name": "Corey Bettenhausen",
                "org": "NASA Goddard Space Flight Center; Greenbelt MD USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences; Texas A&M University; College Station TX USA"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2017
    },
    "dIUxEVal": {
        "id": "dIUxEVal",
        "title": "Multilayer Cloud Detection with the MODIS Near-Infrared Water Vapor Absorption Band",
        "abstract": "",
        "keywords": [
            "near infrared",
            "remote sensing",
            "infrared radiation",
            "water vapor",
            "carbon dioxide",
            "thermodynamics",
            "absorption spectra"
        ],
        "authors": [
            {
                "name": "galina wind",
                "org": ""
            },
            {
                "name": "steven platnick",
                "org": ""
            },
            {
                "name": "michael d king",
                "org": ""
            },
            {
                "name": "p a hubanks",
                "org": ""
            },
            {
                "name": "michael j pavolonis",
                "org": ""
            },
            {
                "name": "andrew k heidinger",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "bryan a baum",
                "org": ""
            }
        ],
        "venue": "Journal of Applied Meteorology and Climatology",
        "year": 2010
    },
    "EVxbXejd": {
        "id": "EVxbXejd",
        "title": "Improvement of Ice Cloud Optical Models at Visible through Far-Infrared Wavelengths",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bryan a baum",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "andrew j heymsfield",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2009
    },
    "Uu98K93D": {
        "id": "Uu98K93D",
        "title": "A fast infrared radiative transfer model for overlapping clouds",
        "abstract": "Abstract A fast infrared radiative transfer model,(FIRTM2) appropriate,for application to both single-layered and,overlapping cloud situations is developed,for simulating the outgoing,infrared spectral radiance at the top of the atmosphere,(TOA). In FIRTM2 a pre-computed,library of cloud reflectance and,transmittance,values is employed,to account,for one or two cloud layers, whereas the background atmospheric optical thickness due to gaseous absorption can be computed from a clear-sky radiative transfer model. FIRTM2 is applicable to three atmospheric conditions: (1) clear-sky, (2) single-layered ice or water cloud, and (3) two simultaneous cloud layers in a column (e.g., ice cloud overlying water cloud). Moreover, FIRTM2 outputs the derivatives (i.e., Jacobians) of the TOA brightness temperature with respect to cloud optical thickness and effective particle size. Sensitivity analyses have been carried out to assess the performance,of FIRTM2 for two spectral regions, namely the longwave (LW) band (587.3\u20131179.5 cm, 1). The assessment,is carried out,in terms,of brightness,temperature,differences (BTD) between FIRTM2 and the well-known discrete ordinates radiative transfer model (DISORT), henceforth referred to as BTD (F\ufffd D). The BTD (F\ufffd D) values for single-layered clouds are generally less than 0.8 K. For the case of two,cloud layers (specifically ice cloud over water cloud), the BTD (F\ufffd D) values are also generally less than 0.8 K except for the SMW band for the case of a very high altitude (415 km) cloud comprised of small ice particles. Note that for clear-sky atmospheres, FIRTM2 reduces to the clear-sky radiative transfer model that is incorporated into FIRTM2, and the errors in this case are essentially those of the clear-sky radiative transfer model. r,2006 Elsevier Ltd. All rights reserved. Keywords: Infrared radiative transfer; Fast code; Cloud; Single scattering properties of cloud",
        "keywords": [
            "fast code",
            "infrared radiative transfer",
            "single scattering properties of cloud",
            "cloud",
            "optical thickness",
            "spectral bands",
            "brightness temperature",
            "sensitivity analysis",
            "radiative transfer",
            "infrared",
            "infrared radiation",
            "high altitude",
            "particle size",
            "radiative transfer model",
            "cloud cover"
        ],
        "authors": [
            {
                "name": "Jianguo Niu",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Hung-Lung Huang",
                "org": "Cooperative Institute of Satellite Study University of Wisconsin, Madison, WI 53706, USA"
            },
            {
                "name": "James E. Davies",
                "org": "Cooperative Institute of Satellite Study University of Wisconsin, Madison, WI 53706, USA"
            },
            {
                "name": "Jun Li",
                "org": "Cooperative Institute of Satellite Study University of Wisconsin, Madison, WI 53706, USA"
            },
            {
                "name": "Bryan A. Baum",
                "org": "NASA Langley Research Center, Hampton, VA 23681, USA"
            },
            {
                "name": "Yong X. Hu",
                "org": "NASA Langley Research Center, Hampton, VA 23681, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy and Radiative Transfer",
        "year": 2007
    },
    "6I7d4I7E": {
        "id": "6I7d4I7E",
        "title": "The effects of surface roughness on the scattering properties of hexagonal columns with sizes from the Rayleigh to the geometric optics regimes",
        "abstract": "",
        "keywords": [
            "ice crystal",
            "surface roughness",
            "light scattering"
        ],
        "authors": [
            {
                "name": "chao liu",
                "org": ""
            },
            {
                "name": "r lee panetta",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2013
    },
    "WFecGeQr": {
        "id": "WFecGeQr",
        "title": "Characteristics of tropical cirrus cloud optical thickness fields using MODIS level-3 data",
        "abstract": "",
        "keywords": [
            "satellites",
            "reflectivity",
            "crystals",
            "high altitude"
        ],
        "authors": [
            {
                "name": "kerry meyer",
                "org": "texas a m university"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "bocai gao",
                "org": "united states naval research laboratory"
            },
            {
                "name": "warren j wiscombe",
                "org": "goddard space flight center"
            }
        ],
        "venue": "",
        "year": 2004
    },
    "8WsaGVbA": {
        "id": "8WsaGVbA",
        "title": "Development of Ice Cloud Microphysical and Optical Models at Visible to Far-Infrared Wavelengths",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bryan a baum",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "andrew j heymsfield",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2005
    },
    "Ec6QuqFz": {
        "id": "Ec6QuqFz",
        "title": "Scattering of partially coherent electromagnetic beams by water droplets and ice crystals",
        "abstract": "",
        "keywords": [
            "mueller matrix",
            "ice crystal"
        ],
        "authors": [
            {
                "name": "jianping liu",
                "org": ""
            },
            {
                "name": "lei bi",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "george w kattawar",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2014
    },
    "AuExvRbM": {
        "id": "AuExvRbM",
        "title": "Intercomparison of the GOS approach, superposition T-matrix method, and laboratory measurements for black carbon optical properties during aging",
        "abstract": "Abstract   We perform a comprehensive intercomparison of the geometric-optics surface-wave (GOS) approach, the superposition T-matrix method, and laboratory measurements for optical properties of fresh and coated/aged black carbon (BC) particles with complex structures. GOS and T-matrix calculations capture the measured optical (i.e., extinction, absorption, and scattering) cross sections of fresh BC aggregates, with 5\u201320% differences depending on particle size. We find that the T-matrix results tend to be lower than the measurements, due to uncertainty in theoretical approximations of realistic BC structures, particle property measurements, and numerical computations in the method. On the contrary, the GOS results are higher than the measurements (hence the T-matrix results) for BC radii  100\u00a0nm. We find good agreement (differences  100\u00a0nm. We find small deviations (\u226410%) in asymmetry factors computed from the two methods for most BC coating structures and sizes, but several complex structures have 10\u201330% differences. This study provides the foundation for downstream application of the GOS approach in radiative transfer and climate studies.",
        "keywords": "",
        "authors": [
            {
                "name": "Cenlin He",
                "org": "Department of Atmospheric and Oceanic Sciences and Joint Institute for Earth System Science and Engineering, University of California, Los Angeles, CA 90095, USA"
            },
            {
                "name": "Y. Takano",
                "org": "Department of Atmospheric and Oceanic Sciences and Joint Institute for Earth System Science and Engineering, University of California, Los Angeles, CA 90095, USA"
            },
            {
                "name": "Kuo-Nan Liou",
                "org": "Department of Atmospheric and Oceanic Sciences and Joint Institute for Earth System Science and Engineering, University of California, Los Angeles, CA 90095, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M, College Station, TX 77845, USA"
            },
            {
                "name": "Qinbin Li",
                "org": "Department of Atmospheric and Oceanic Sciences and Joint Institute for Earth System Science and Engineering, University of California, Los Angeles, CA 90095, USA"
            },
            {
                "name": "Daniel W. Mackowski",
                "org": "Department of Mechanical Engineering, Auburn University, Auburn, AL 36849, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2016
    },
    "tmGKGpAQ": {
        "id": "tmGKGpAQ",
        "title": "Retrieval of ice cloud properties using an optimal estimation algorithm and MODIS infrared observations: 2. Retrieval evaluation: Comparison of Ice Cloud Retrievals",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Chenxi Wang",
                "org": "Earth System Science Interdisciplinary Center; University of Maryland; College Park Maryland USA"
            },
            {
                "name": "Steven Platnick",
                "org": "NASA Goddard Space Flight Center; Greenbelt Maryland USA"
            },
            {
                "name": "Zhibo Zhang",
                "org": "Department of Physics; University of Maryland, Baltimore County; Baltimore Maryland USA"
            },
            {
                "name": "Kerry Meyer",
                "org": "NASA Goddard Space Flight Center; Greenbelt Maryland USA"
            },
            {
                "name": "Kerry Meyer",
                "org": "NASA Goddard Space Flight Center; Greenbelt Maryland USA"
            },
            {
                "name": "Gala Wind",
                "org": "NASA Goddard Space Flight Center; Greenbelt Maryland USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences; Texas A&M University; College Station Texas USA"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2016
    },
    "2cKTqMGz": {
        "id": "2cKTqMGz",
        "title": "Differences Between Collection 4 and 5 MODIS Ice Cloud Optical/Microphysical Products and Their Impact on Radiative Forcing Simulations",
        "abstract": "This paper reports on the comparison of two latest versions (collections 4 and 5) of ice cloud products derived from the Moderate Resolution Imaging Spectroradiometer (MODIS) measurements. The differences between the bulk optical properties of ice clouds used in collections 4 and 5 and the relevant impact on simulating the correlation of the bidirectional reflection functions at two MODIS bands centered at 0.65 (or 0.86) and 2.13 mum are investigated. The level-3 MODIS ice cloud properties (specifically, ice cloud fraction, optical thickness, and effective particle size in this paper) from the collection 4 and 5 datasets are compared for a tropical belt of 30deg S-30deg N. Furthermore, the impact of the differences between the MODIS collection 4 and 5 ice cloud products on the simulation of the radiative forcing of these clouds is investigated. Over the tropics, the averaged ice cloud fraction from collection 5 is 1.1% more than the collection 4 counterpart, the averaged optical thickness from collection 5 is 1.2 larger than the collection 4 counterpart, and the averaged effective particle radius from collection 5 is 1.8 mum smaller than the collection 4 counterpart. Moreover, the magnitude of the differences between collection 5 and 4 ice cloud properties also depends on the surface characteristics, i.e., over land or over ocean. The differences of these two datasets (collections 4 and 5) of cloud properties can have a significant impact on the simulation of the radiative forcing of ice clouds. In terms of total (longwave plus shortwave) cloud radiative forcing, the differences between the collection 5 and 4 results are distributed primarily between -60 and 20 W ldr m-2 but peak at 0 W ldr m-2.",
        "keywords": [
            "remote sensing",
            "ice cloud microphysical products",
            "modis collection 5",
            "cloud radiative forcing",
            "static libraries.",
            "static libraries",
            "moderate resolution imaging spectroradiometer (modis)",
            "optical thickness",
            "cloud property",
            "moderate resolution imaging spectroradiometer modis",
            "clouds",
            "ice",
            "radiative forcing",
            "effective particle size",
            "ice cloud optical products",
            "ice cloud fraction",
            "aqua",
            "radiative forcing simulations",
            "index terms\u2014aqua",
            "moderate resolution imaging spectroradiometer",
            "modis collection 4",
            "atmospheric radiation",
            "particle size"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Lei Zhang",
                "org": ""
            },
            {
                "name": "Gang Hong",
                "org": ""
            },
            {
                "name": "Shaima L. Nasiri",
                "org": ""
            },
            {
                "name": "Bryan A. Baum",
                "org": ""
            },
            {
                "name": "Hung-Lung Huang",
                "org": ""
            },
            {
                "name": "Michael D. King",
                "org": ""
            },
            {
                "name": "Steven Platnick",
                "org": ""
            }
        ],
        "venue": "IEEE T. Geoscience and Remote Sensing",
        "year": 2007
    },
    "jbuQ72mk": {
        "id": "jbuQ72mk",
        "title": "Polarized radiance fields under a dynamic ocean surface: a three-dimensional radiative transfer solution.",
        "abstract": "The hybrid matrix operator, Monte Carlo (HMOMC) method previously reported [Appl. Opt.47, 1063-1071 (2008)] is improved by neglecting higher-order terms in the coupling of the matrix operators and by introducing a dual grid scheme. The computational efficiency for solving the vector radiative transfer equation in a full 3D coupled atmosphere-surface-ocean system is substantially improved, and, thus, large-scale simulations of the radiance distribution become feasible. The improved method is applied to the computation of the polarized radiance field under realistic surface waves simulated by the power spectral density method. To the authors' best knowledge, this is the first time that the polarized radiance field under a dynamic ocean surface and the underwater image of an object above such an ocean surface have been reported.",
        "keywords": [
            "three dimensional",
            "atmospheric optics",
            "radiative transfer"
        ],
        "authors": [
            {
                "name": "Yu You",
                "org": ""
            },
            {
                "name": "Peng-Wang Zhai",
                "org": ""
            },
            {
                "name": "George W Kattawar",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences|Texas A&M University"
            }
        ],
        "venue": "Applied optics",
        "year": 2009
    },
    "NDFDFJ22": {
        "id": "NDFDFJ22",
        "title": "Single-scattering properties of ice particles in the microwave regime: Temperature effect on the ice refractive index with implications in remote sensing",
        "abstract": "Abstract   An ice crystal single-scattering property database is developed in the microwave spectral region (1 to 874\u00a0GHz) to provide the scattering, absorption, and polarization properties of 12 ice crystal habits (10-plate aggregate, 5-plate aggregate, 8-column aggregate, solid hexagonal column, hollow hexagonal column, hexagonal plate, solid bullet rosette, hollow bullet rosette, droxtal, oblate spheroid, prolate spheroid, and sphere) with particle maximum dimensions from 2\u00a0\u00b5m to 10\u00a0mm. For each habit, four temperatures (160, 200, 230, and 270\u00a0K) are selected to account for temperature dependence of the ice refractive index. The microphysical and scattering properties include projected area, volume, extinction efficiency, single-scattering albedo, asymmetry factor, and six independent nonzero phase matrix elements (i.e. P 11 , P 12 , P 22 , P 33 , P 43  and P 44 ). The scattering properties are computed by the Invariant Imbedding T-Matrix (II-TM) method and the Improved Geometric Optics Method (IGOM). The computation results show that the temperature dependence of the ice single-scattering properties in the microwave region is significant, particularly at high frequencies. Potential active and passive remote sensing applications of the database are illustrated through radar reflectivity and radiative transfer calculations. For cloud radar applications, ignoring temperature dependence has little effect on ice water content measurements. For passive microwave remote sensing, ignoring temperature dependence may lead to brightness temperature biases up to 5\u00a0K in the case of a large ice water path.",
        "keywords": "",
        "authors": [
            {
                "name": "Jiachen Ding",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, USA"
            },
            {
                "name": "Lei Bi",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, USA"
            },
            {
                "name": "George W. Kattawar",
                "org": "Department of Physics & Astronomy, Texas A&M University, College Station, TX, USA"
            },
            {
                "name": "Fuzhong Weng",
                "org": "Satellite Meteorology and Climatology Division, Center for Satellite Applications and Research, NOAA/NESDIS, Camp Springs, MD 20746, USA"
            },
            {
                "name": "Quanhua Liu",
                "org": "Satellite Meteorology and Climatology Division, Center for Satellite Applications and Research, NOAA/NESDIS, Camp Springs, MD 20746, USA"
            },
            {
                "name": "Thomas J. Greenwald",
                "org": "Cooperative Institute for Meteorological Satellite Studies, University of Wisconsin-Madison, Madison, WI, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2017
    },
    "0kh1ZxxU": {
        "id": "0kh1ZxxU",
        "title": "Effects of particle nonsphericity and radiation polarization on retrieving dust properties from MODIS observations",
        "abstract": "",
        "keywords": [
            "polarization",
            "lookup table",
            "radiation",
            "algorithms",
            "mineral dust",
            "radiative transfer",
            "geometric optics",
            "aerosol optical depth",
            "mie theory"
        ],
        "authors": [
            {
                "name": "Qian Feng",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "George W. Kattawar",
                "org": ""
            },
            {
                "name": "Christina N. Hsu",
                "org": ""
            },
            {
                "name": "Si-Chee Tsay",
                "org": ""
            },
            {
                "name": "Istvan Laszlo",
                "org": ""
            }
        ],
        "venue": "Journal of Aerosol Science",
        "year": 2009
    },
    "fDWlueYx": {
        "id": "fDWlueYx",
        "title": "Bulk Scattering Properties for the Remote Sensing of Ice Clouds. Part III: High-Resolution Spectral Models from 100 to 3250 cm-1",
        "abstract": "",
        "keywords": [
            "radiative transfer",
            "particle size distribution",
            "spline interpolation",
            "infrared",
            "far infrared",
            "high resolution",
            "international satellite cloud climatology project",
            "remote sensing"
        ],
        "authors": [
            {
                "name": "bryan a baum",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "shaima l nasiri",
                "org": ""
            },
            {
                "name": "andrew k heidinger",
                "org": ""
            },
            {
                "name": "andrew j heymsfield",
                "org": ""
            },
            {
                "name": "jun li",
                "org": ""
            }
        ],
        "venue": "Journal of Applied Meteorology and Climatology",
        "year": 2007
    },
    "AfFvI4Tg": {
        "id": "AfFvI4Tg",
        "title": "Enhancement of the computational efficiency of the near-to-far field mapping in the finite-difference method and ray-by-ray method with the fast multi-pole plane wave expansion approach",
        "abstract": "Abstract   The finite-difference time-domain (FDTD) and ray-by-ray (RBR) methods are techniques used to calculate the optical properties of nonspherical particles for small-to-moderate and large size parameters, respectively. The former is a rigorous method, and the latter is an approximate geometric\u2013physical optics-hybrid method that takes advantage of both high efficiency of the geometric optics approach and high accuracy of the physical optics approach. In these two methods, the far field is calculated by mapping the near field to the far field with consideration of the phase interference. The mapping computation is more time-consuming than the near-field simulation when multiple scattering directions are involved, particularly in the case of the RBR implementation. To overcome the difficulty, in this study the fast multi-pole method is applied to both FDTD and RBR towards accelerating the far-field calculation, without degrading the accuracy of the simulation results.",
        "keywords": "",
        "authors": [
            {
                "name": "Guanglin Tang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, USA"
            },
            {
                "name": "Bingqiang Sun",
                "org": "Department of Physics & Astronomy, Texas A&M University, College Station, TX, USA"
            },
            {
                "name": "R. Lee Panetta",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, USA"
            },
            {
                "name": "George W. Kattawar",
                "org": "Department of Physics & Astronomy and Institute for Quantum Science and Engineering, Texas A&M University, College Station, TX, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2016
    },
    "7y5Xv7DW": {
        "id": "7y5Xv7DW",
        "title": "Uncertainties Associated With the Surface Texture of Ice Particles in Satellite-Based Retrieval of Cirrus Clouds: Part II\u2014Effect of Particle Surface Roughness on Retrieved Cloud Optical Thickness and Effective Particle Size",
        "abstract": "The simplified ray-tracing technique reported in Part I of this paper is employed to compute the single-scattering properties of hexagonal columns with maximum dimensions ranging from 2 to 3500 mum with a size-bin resolution of 2 mum at wavelengths of 0.86 and 2.13 mum. For small ice crystals, the current treatment of surface roughness may not be adequate because the applicability of the principles of geometric optics breaks down for small roughness scale. However, for ice crystals smaller than 40 mum, the aspect ratios of these particles are close to one, and the effect of surface roughness is quite small. In this paper, the diffraction is accounted for in the same way as in the case of smooth particles. It is essentially unfeasible to incorporate the effect of surface roughness into the numerical computation of the diffraction contribution. The scattering properties of individual ice crystals are then averaged over 18 particle size distributions whose effective particle radii (re) range from 5 to 90 mum. The single-scattering properties of ice clouds are strongly sensitive to surface roughness condition. Lookup tables that are built for the correlation between the bidirectional reflectances at wavelengths of 0.86 and 2.13 mum with different roughness conditions are used to retrieve ice cloud optical thickness and effective particle size over oceans. Pronounced differences are noticed for the retrieved cirrus cloud optical thickness and effective particle sizes in conjunction with different surface roughness conditions. The values of the retrieved cirrus cloud optical thickness in the case of the rough surface are generally smaller than their counterparts associated with smooth surface conditions. The effect of surface roughness on the retrieved effective particle radii is not pronounced for slight and moderate roughness conditions. However, when the surfaces of ice crystals are substantially rough, the retrieved effective radii associated with roughened- - particles are larger and smaller than their smooth surface counterparts forlarge (re>50 mum) and small (re<35 mum) ice crystals, respectively, whereas the effect of surface roughness on the retrieved effective radii shows a nonmonotonic feature for moderate particle sizes (35 mum<re<50 mum). In general, the dominant effect of surface roughness on cloud property retrievals is to decrease the retrieved optical thickness and to increase the retrieved effective particle size in comparison with their counterparts in the case of smooth ice particles.",
        "keywords": [
            "remote sensing",
            "ray-tracing technique",
            "surface roughness",
            "scattering",
            "geometric optics",
            "ice particles surface texture",
            "ray tracing",
            "ice crystals",
            "cirrus clouds",
            "optical depth",
            "particle surface roughness effect",
            "ice cloud optical thickness",
            "clouds",
            "satellite-based retrieval",
            "ice",
            "effective particle size",
            "cloud property retrievals",
            "single-scattering properties",
            "optical scattering",
            "uncertainty",
            "rough surfaces",
            "particle size",
            "surface texture",
            "lookup table",
            "aspect ratio",
            "particle size distribution"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Gang Hong",
                "org": ""
            },
            {
                "name": "George W. Kattawar",
                "org": ""
            },
            {
                "name": "Patrick Minnis",
                "org": ""
            },
            {
                "name": "Yongxiang Hu",
                "org": ""
            }
        ],
        "venue": "IEEE T. Geoscience and Remote Sensing",
        "year": 2008
    },
    "XBR9WMcH": {
        "id": "XBR9WMcH",
        "title": "Optical tunneling by arbitrary macroscopic three-dimensional objects",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Lei Bi",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "George W. Kattawar",
                "org": ""
            },
            {
                "name": "Michael I. Mishchenko",
                "org": ""
            }
        ],
        "venue": "Physical Review A",
        "year": 2015
    },
    "rC9ik9Uh": {
        "id": "rC9ik9Uh",
        "title": "The Next Generation of Ice Cloud Bulk Scattering/Absorption Models at Visible through Infrared Wavelengths",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "andrew j heymsfield",
                "org": ""
            },
            {
                "name": "bryan a baum",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2011
    },
    "8Y6rDECa": {
        "id": "8Y6rDECa",
        "title": "P2.20 HYPERSPECTRAL INFRARED ICE CLOUD PROPERTY RETRIEVAL DEMONSTRATION - THEORETICAL AND CASE STUDY ANALYSIS",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Hung-Lung Huang",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "He-Li Wei",
                "org": ""
            },
            {
                "name": "Bryan A. Baum",
                "org": ""
            },
            {
                "name": "Yongxiang Hu",
                "org": ""
            },
            {
                "name": "Steven A. Ackerman",
                "org": ""
            }
        ],
        "venue": "",
        "year": 0
    },
    "xN9BPrTB": {
        "id": "xN9BPrTB",
        "title": "A Report of Findings and Recommendations \u2014 Executive Summary. Workshop on the Impact of Aviation on Climate Change, June 7-9, 2006, Boston, MA",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "donald j wuebbles",
                "org": ""
            },
            {
                "name": "anne r douglass",
                "org": ""
            },
            {
                "name": "b karcher",
                "org": ""
            },
            {
                "name": "weichyung wang",
                "org": ""
            },
            {
                "name": "steve baughum",
                "org": ""
            },
            {
                "name": "robert p dentremont",
                "org": ""
            },
            {
                "name": "a e dessler",
                "org": ""
            },
            {
                "name": "paul ginoux",
                "org": ""
            },
            {
                "name": "redina herman",
                "org": ""
            },
            {
                "name": "andrew j heymsfield",
                "org": ""
            },
            {
                "name": "i s a isaksen",
                "org": ""
            },
            {
                "name": "daniel j jacob",
                "org": ""
            },
            {
                "name": "sanjiva lele",
                "org": ""
            },
            {
                "name": "jennifer a logan",
                "org": ""
            },
            {
                "name": "j c mcconnell",
                "org": ""
            },
            {
                "name": "richard c miakelye",
                "org": ""
            },
            {
                "name": "patrick minnis",
                "org": ""
            },
            {
                "name": "dave mitchell",
                "org": ""
            },
            {
                "name": "d m murphy",
                "org": ""
            },
            {
                "name": "l pan",
                "org": ""
            },
            {
                "name": "joyce e penner",
                "org": ""
            },
            {
                "name": "michael j prather",
                "org": ""
            },
            {
                "name": "j m rodriguez",
                "org": ""
            },
            {
                "name": "karen h rosenlof",
                "org": ""
            },
            {
                "name": "kenneth sassen",
                "org": ""
            },
            {
                "name": "robert sausen",
                "org": ""
            },
            {
                "name": "keith p shine",
                "org": ""
            },
            {
                "name": "azadeh tabazadeh",
                "org": ""
            },
            {
                "name": "ian a waitz",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "fangqun yu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2006
    },
    "Sr4nF6AJ": {
        "id": "Sr4nF6AJ",
        "title": "Radiative Properties of Cirrus Clouds in the Infrared (8-13 microns) Spectral Region",
        "abstract": "",
        "keywords": [
            "geometric optics",
            "crystal",
            "geometrical optics",
            "power law",
            "finite difference time domain",
            "tropical regions",
            "effect size",
            "infrared radiation",
            "parameterization",
            "infrared",
            "spectral bands",
            "asymmetry",
            "particle size",
            "second order",
            "remote sensing"
        ],
        "authors": [
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "bocai gao",
                "org": "united states naval research laboratory"
            },
            {
                "name": "bryan a baum",
                "org": "langley research center"
            },
            {
                "name": "y x hu",
                "org": "langley research center"
            },
            {
                "name": "warren j wiscombe",
                "org": "goddard space flight center"
            },
            {
                "name": "sichee tsay",
                "org": "goddard space flight center"
            },
            {
                "name": "dave winker",
                "org": "langley research center"
            },
            {
                "name": "franco einaudi",
                "org": "cooperative institute for meteorological satellite studies"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2000
    },
    "Hy1mzD3L": {
        "id": "Hy1mzD3L",
        "title": "Parameterization of shortwave cloud optical properties for a mixture of ice particle habits for use in atmospheric models",
        "abstract": "On the basis of single-scattering optical properties precomputed with an improved geometric optics method, the bulk absorption coefficient, single-scattering albedo, and asymmetry factor of ice particles have been parameterized as a function of the effective particle size of a mixture of ice habits, the ice water amount, and spectral band. The parameterization has been applied to computing fluxes for sample clouds with various particle size distributions and assumed mixtures of particle habits. It is found that flux calculations are not overly sensitive to the assumed particle habits if the definition of the effective particle size is consistent with the particle habits on which the parameterization is based. Otherwise, the error in the flux calculations could reach a magnitude unacceptable for climate studies. Different from many previous studies, the parameterization requires only an effective particle size representing all ice habits in a cloud layer but not the effective size of individual ice habits.",
        "keywords": [
            "radiation and climate",
            "transmission and absorption of radiation",
            "cloud microphysical and optical properties",
            "atmospheric models",
            "effect size",
            "absorption coefficient",
            "particle size",
            "particle size distribution",
            "spectral bands",
            "atmospheric modeling",
            "geometrical optics",
            "scattering",
            "geometric optics",
            "parameterization",
            "asymmetry",
            "cloud cover"
        ],
        "authors": [
            {
                "name": "mingdah chou",
                "org": "goddard space flight center"
            },
            {
                "name": "kyutae lee",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2002
    },
    "fRMSJEPM": {
        "id": "fRMSJEPM",
        "title": "Study of ice cloud properties using infrared spectral data",
        "abstract": "",
        "keywords": [
            "crystals",
            "radiative forcing",
            "spectrum",
            "infrared"
        ],
        "authors": [
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "heli wei",
                "org": "texas a m university"
            },
            {
                "name": "yongkeun lee",
                "org": "texas a m university"
            },
            {
                "name": "jianguo niu",
                "org": "texas a m university"
            },
            {
                "name": "hunglung huang",
                "org": "university of wisconsin madison"
            },
            {
                "name": "bryan a baum",
                "org": "langley research center"
            },
            {
                "name": "yongxiang hu",
                "org": "langley research center"
            },
            {
                "name": "jun li",
                "org": "university of wisconsin madison"
            }
        ],
        "venue": "",
        "year": 2005
    },
    "TYQxGKiT": {
        "id": "TYQxGKiT",
        "title": "Bulk Scattering Properties for the Remote Sensing of Ice Clouds. Part II: Narrowband Models",
        "abstract": "This study examines the development of bulk single-scattering properties of ice clouds, including single- scattering albedo, asymmetry factor, and phase function, for a set of 1117 particle size distributions obtained from analysis of the First International Satellite Cloud Climatology Project Regional Experiment (FIRE)-I, FIRE-II, Atmospheric Radiation Measurement Program intensive observation period, Tropical Rainfall Measuring Mission Kwajalein Experiment (KWAJEX), and the Cirrus Regional Study of Tropical Anvils and Cirrus Layers (CRYSTAL) Florida Area Cirrus Experiment (FACE) data. The primary focus is to develop band-averaged models appropriate for use by the Moderate Resolution Imaging Spectroradiometer (MODIS) imager on the Earth Observing System Terra and Aqua platforms, specifically for bands located at wavelengths of 0.65, 1.64, 2.13, and 3.75 m. The results indicate that there are substantial differences in the bulk scattering properties of ice clouds formed in areas of deep convection and those that exist in areas of much lower updraft velocities. Band-averaged bulk scattering property results obtained from a particle- size-dependent mixture of ice crystal habits are compared with those obtained assuming only solid hex- agonal columns. The single-scattering albedo is lower for hexagonal columns than for a habit mixture for the 1.64-, 2.13-, and 3.75-m bands, with the differences increasing with wavelength. In contrast, the asymmetry factors obtained from the habit mixture and only the solid hexagonal column are most different at 0.65 m, with the differences decreasing as wavelength increases. At 3.75 m, the asymmetry factor results from the two habit assumptions are almost indistinguishable. The asymmetry factor, single-scattering albedo, and scattering phase functions are also compared with the MODIS version-1 (V1) models. Differ- ences between the current and V1 models can be traced to the microphysical models and specifically to the number of both the smallest and the largest particles assumed in the size distributions.",
        "keywords": [],
        "authors": [
            {
                "name": "Bryan A. Baum",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Andrew J. Heymsfield",
                "org": ""
            },
            {
                "name": "Steven Platnick",
                "org": ""
            },
            {
                "name": "Michael D. King",
                "org": ""
            },
            {
                "name": "Y.-X. HU",
                "org": ""
            },
            {
                "name": "Sarah T. Bedka",
                "org": ""
            }
        ],
        "venue": "Journal of Applied Meteorology",
        "year": 2005
    },
    "2isYNUJD": {
        "id": "2isYNUJD",
        "title": "Spectrally Consistent Scattering, Absorption, and Polarization Properties of Atmospheric Ice Crystals at Wavelengths from 0.2 to 100 \u03bcm",
        "abstract": "",
        "keywords": [
            "asymmetry",
            "ice crystals",
            "surface roughness",
            "extinction",
            "radiative transfer",
            "remote sensing"
        ],
        "authors": [
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "lei bi",
                "org": ""
            },
            {
                "name": "bryan a baum",
                "org": ""
            },
            {
                "name": "kuonan liou",
                "org": ""
            },
            {
                "name": "george w kattawar",
                "org": ""
            },
            {
                "name": "michael i mishchenko",
                "org": ""
            },
            {
                "name": "benjamin h cole",
                "org": ""
            }
        ],
        "venue": "Journal of the Atmospheric Sciences",
        "year": 2013
    },
    "7Z2hekCB": {
        "id": "7Z2hekCB",
        "title": "Ice cloud backscatter study and comparison with CALIPSO and MODIS satellite data",
        "abstract": "",
        "keywords": [
            "general"
        ],
        "authors": [
            {
                "name": "jiachen ding",
                "org": "texas a m university"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "robert e holz",
                "org": "university of wisconsin madison"
            },
            {
                "name": "steven platnick",
                "org": "goddard space flight center"
            },
            {
                "name": "kerry meyer",
                "org": "goddard space flight center"
            },
            {
                "name": "mark a vaughan",
                "org": "langley research center"
            },
            {
                "name": "yongxiang hu",
                "org": "langley research center"
            },
            {
                "name": "michael d king",
                "org": "university of colorado boulder"
            }
        ],
        "venue": "Optics Express",
        "year": 2016
    },
    "VJs4aVNP": {
        "id": "VJs4aVNP",
        "title": "Effective multi-scattering-stream model for fast radiative transfer simulation",
        "abstract": "",
        "keywords": [
            "atmospheric optics",
            "radiative transfer"
        ],
        "authors": [
            {
                "name": "qiguang yang",
                "org": "langley research center"
            },
            {
                "name": "xu liu",
                "org": "langley research center"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "chenxi wang",
                "org": "texas a m university"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "uZuiqaKT": {
        "id": "uZuiqaKT",
        "title": "Modeling of the scattering and radiative properties of nonspherical dust-like aerosols",
        "abstract": "Abstract The optical and radiative properties of dust particles in solar and thermal infrared regions are investigated. Dust particles are assumed,to be spheres and spheroids for a comparison,aimed at understanding,the nonsphericity effect of these particles on the radiation at the top of a dusty atmosphere. The classical Lorenz\u2013Mie theory is employed,to compute the optical properties of spherical dust particles. To compute the single-scattering properties of spheroidal dust particles, a combination of the T-matrix method and an approximate method is used in the present study. In the approximate method, applicable to large particles, the geometric optics method,is applied to the computation,of the scattering phase matrix. A combination,of the solution from the geometric optics method,and the contribution of the so-called edge effect is used to compute,the extinction efficiency of a spheroidal particle whose absorption efficiency is computed,by adding the so-called above- and below-edge effect (a term from the well-known complex angular momentum,theory) to the geometric optics result. Numerical results show that the results from the T-matrix method,and the present approximate approach converge at a size parameter of 50 for computing the integrated scattering properties (i.e., the extinction efficiency, single-scattering albedo, and asymmetry factor). Additionally, the phase functions computed from the two methods are quite similar for size parameters larger than 40 although some considerable differences may,still be noticed for other phase matrix elements. Furthermore, the effect of surface roughness on the single-scattering properties of spheroidal particles is discussed. The present radiative transfer simulations illustrate the nonsphericity effect of dust particles is significant at short wavelengths, however, not at the thermal infrared wavelengths.  2007 Elsevier Ltd. All rights reserved. Keywords: Single-scattering property; Nonspherical dust particle; Solar and infrared radiances; Remote sensing Corresponding author. Tel.: +1 979 845 4923; fax: +1 979 862 4466.",
        "keywords": [
            "single-scattering property",
            "solar and infrared radiances",
            "nonspherical dust particle",
            "remote sensing",
            "angular momentum",
            "geometric optics",
            "radiative transfer",
            "infrared",
            "surface roughness",
            "edge effect",
            "mie theory"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Qian Feng",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Gang Hong",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "George W. Kattawar",
                "org": "Department of Physics, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Warren J. Wiscombe",
                "org": "Code 613.2, NASA Goddard Space Flight Center, Greenbelt, Maryland 20771, USA"
            },
            {
                "name": "Michael I. Mishchenko",
                "org": "NASA Goddard Institute for Space Studies, 2880 Broadway, New York, NY 10025, USA"
            },
            {
                "name": "Oleg Dubovik",
                "org": "Laboratoire d'Optique Atmosph\u00e9rique, Universit\u00e9 de Lille, 1/CNRS, F-59655 Villeneuve d'AAscq, France"
            },
            {
                "name": "Istvan Laszlo",
                "org": "NOAA/NESDIS, Office of Research and Applications, Camp Spring, MD 20746, USA"
            },
            {
                "name": "Irina N. Sokolik",
                "org": "School of Earth and Atmospheric Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA"
            }
        ],
        "venue": "Journal of Aerosol Science",
        "year": 2007
    },
    "UzPHz8Ef": {
        "id": "UzPHz8Ef",
        "title": "Constraints on the optical properties of ice Clouds and Airborne dust based on passive and active remote sensing observations",
        "abstract": "Ice clouds and dust aerosols are two important atmospheric constituents. To reliably assess the radiativeforcings and to accurately infer the microphysical and optical properties of these two atmospheric components, it is necessary to use appropriate optical properties of ice crystals and dust particles. In this talk we will discuss the use of remote sensing techniques based on observations by passive and active sensors to constrain the optical properties. Specifically, we will use the MODIS (Moderate Resolution Imaging Spectroradiometer), POLDER (POLarization and Directionality of the Earthu0027s Reflectances), MISR (Multi-angle Imaging SpectroRadiometer), and CALIOP/CALIPSO (Cloud-Aerosol Lidar with Orthogonal Polarization on the Cloud-Aerosol Lidar with Orthogonal Polarization) measurements in combination of theoretical light scattering simulations to identify the optimal single-scattering properties (extinction coefficient, single-scattering albedo, and phase matrix) of nonspherical/inhomogeneous ice crystals and dust particles.",
        "keywords": "",
        "authors": [
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, USA"
            },
            {
                "name": "Michael D. King",
                "org": "Department of Atmospheric Sciences, Texas A&M University, USA"
            },
            {
                "name": "Guanglin Tang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, USA"
            },
            {
                "name": "Souichiro Hioki",
                "org": "Department of Atmospheric Sciences, Texas A&M University, USA"
            },
            {
                "name": "Jiachen Ding",
                "org": "Department of Atmospheric Sciences, Texas A&M University, USA"
            }
        ],
        "venue": "progress in electromagnetic research symposium",
        "year": 2016
    },
    "20uYPCSL": {
        "id": "20uYPCSL",
        "title": "Aerosol-cloud-precipitation relationships from satellite observations and global climate model simulations",
        "abstract": "",
        "keywords": [
            "physical oceanography",
            "satellites"
        ],
        "authors": [
            {
                "name": "bingqi yi",
                "org": "texas a m university"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "kenneth p bowman",
                "org": "texas a m university"
            },
            {
                "name": "xiaodong liu",
                "org": "chinese academy of sciences"
            }
        ],
        "venue": "Journal of Applied Remote Sensing",
        "year": 2012
    },
    "Abjgat6E": {
        "id": "Abjgat6E",
        "title": "Remote sensing of cloud properties using MODIS airborne simulator imagery during SUCCESS 1. Data and models",
        "abstract": "",
        "keywords": [
            "mie theory",
            "water vapor",
            "cross section",
            "remote sensing",
            "thermodynamics",
            "ozone",
            "particle size",
            "trace gases",
            "radiative transfer"
        ],
        "authors": [
            {
                "name": "Bryan A. Baum",
                "org": ""
            },
            {
                "name": "David P. Kratz",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "S. C. Ou",
                "org": ""
            },
            {
                "name": "Yongxiang Hu",
                "org": ""
            },
            {
                "name": "Peter F. Soulen",
                "org": ""
            },
            {
                "name": "Si-Chee Tsay",
                "org": ""
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2000
    },
    "FBKtAboP": {
        "id": "FBKtAboP",
        "title": "Modeling the inherent optical properties of aquatic particles using an irregular hexahedral ensemble",
        "abstract": "Abstract   A statistical approach in defining particle morphology in terms of an ensemble of hexahedra of distorted shapes is employed for modeling the Inherent Optical Properties (IOPs) of aquatic particles. The approach is inspired by the rich variability in shapes of real aquatic particles that cannot be represented by one particular shape. Two methods, the Invariant Imbedding T-matrix (II-TM) and Physical Geometric Optics Hybrid (PGOH) method, are combined to simulate the IOPs for aquatic particles of sizes ranging from the Rayleigh scattering to geometric optics regimes. Nonspherical effects on the IOPs are examined by comparing the results with predictions based on the Lorenz-Mie theory to explore the limitations of assuming the particles to be spherical. We pay special attention to backscattering-related and polarimetric scattering properties, particularly the backscattering ratio, Gordon parameter, backscattering volume scattering function and the degree of linear polarization. The simulated IOPs are compared with the in-situ measurements to assess the feasibility of using a hexahedral ensemble in modeling the IOPs of the aquatic particles.",
        "keywords": "",
        "authors": [
            {
                "name": "Guanglang Xu",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Bingqiang Sun",
                "org": "Department of Physics & Astronomy, Texas A&M University, USA"
            },
            {
                "name": "Sarah D. Brooks",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "George W. Kattawar",
                "org": "Department of Physics & Astronomy, Texas A&M University, USA"
            },
            {
                "name": "Xiaodong Zhang",
                "org": "Department of Earth System Science and Policy, University of North Dakota, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2017
    },
    "83P9SFQq": {
        "id": "83P9SFQq",
        "title": "Diffraction by rectangular parallelepiped, hexagonal cylinder, and three-axis ellipsoid: Some analytic solutions and numerical results",
        "abstract": "",
        "keywords": [
            "light scattering",
            "fraunhofer diffraction"
        ],
        "authors": [
            {
                "name": "y takano",
                "org": ""
            },
            {
                "name": "k n liou",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2012
    },
    "pSJWwoQA": {
        "id": "pSJWwoQA",
        "title": "Diffraction and external reflection by dielectric faceted particles",
        "abstract": "",
        "keywords": [
            "scattering",
            "refractive index",
            "physical optics",
            "scattering matrix",
            "discrete dipole approximation",
            "diffraction"
        ],
        "authors": [
            {
                "name": "Lei Bi",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "George W. Kattawar",
                "org": "Department of Physics, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Yongxiang Hu",
                "org": "NASA Langley Research Center, Hampton, VA 23681, USA"
            },
            {
                "name": "Bryan A. Baum",
                "org": "Space Science and Engineering Center, University of Wisconsin-Madison, 1225 West Dayton St., Madison, WI 53706, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy and Radiative Transfer",
        "year": 2011
    },
    "71YTM1Zj": {
        "id": "71YTM1Zj",
        "title": "Effect of Cavities on the Optical Properties of Bullet Rosettes: Implications for Active and Passive Remote Sensing of Ice Cloud Properties",
        "abstract": "Bullet rosette particles are common in ice clouds, and the bullets may often be hollow. Here the single- scattering properties of randomly oriented hollow bullet rosette ice particles are investigated. A bullet, which is an individual branch of a rosette, is defined as a hexagonal column attached to a hexagonal pyramidal tip. For this study, a hollow structure is included at the end of the columnar part of each bullet branch and the shape of the hollow structure is defined as a hexagonal pyramid. A hollow bullet rosette may have between 2 and 12 branches. An improved geometric optics method is used to solve for the scattering of light in the particle. The primary optical effect of incorporating a hollow end in each of the bullets is to decrease the magnitude of backscattering. In terms of the angular distribution of scattered energy, the hollow bullets increase the scattering phase function values within the forward scattering angle region from 1\u00b0 to 20\u00b0 but decrease the phase function values at side- and backscattering angles of 60\u00b0-180\u00b0. As a result, the presence of hollow bullets tends to increase the asymmetry factor. In addition to the scattering phase function, the other elements of the phase matrix are also discussed. The backscattering depolarization ratios for hollow and solid bullet rosettes are found to be very different. This may have an implication for active remote sensing of ice clouds, such as from polarimetric lidar measurements. In a comparison of solid and hollow bullet rosettes, the effect of the differences on the retrieval of both the ice cloud effective particle size and optical thickness is also discussed. It is found that the presence of hollow bullet rosettes acts to decrease the inferred effective particle size and to increase the optical thickness in comparison with the use of solid bullet rosettes.",
        "keywords": [],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Zhibo Zhang",
                "org": ""
            },
            {
                "name": "George W. Kattawar",
                "org": ""
            },
            {
                "name": "Stephen G. Warren",
                "org": ""
            },
            {
                "name": "Bryan A. Baum",
                "org": ""
            },
            {
                "name": "Hung-Lung Huang",
                "org": ""
            },
            {
                "name": "Yong X. Hu",
                "org": ""
            },
            {
                "name": "David Winker",
                "org": ""
            },
            {
                "name": "Jean Iaquinta",
                "org": ""
            }
        ],
        "venue": "Journal of Applied Meteorology and Climatology",
        "year": 2008
    },
    "JoLQPKyq": {
        "id": "JoLQPKyq",
        "title": "Optical properties of ice particles in young contrails",
        "abstract": "The single-scattering properties of four types of ice crystals (pure ice crystals, ice crystals with an internal mixture of ice and black carbon, ice crystals coated with black carbon, and soot coated with ice) in young contrails are investigated at wavelengths 0.65 and 2.13mm using Mie codes for coated spheres. The four types of ice crystals show differences in their single-scattering properties because of the embedded black carbon whose volume ratio is assumed to be 5%. The bulk-scattering properties of young contrails consisting of the four types of ice crystals are further investigated by averaging their single-scattering properties over a typical ice particle size distribution found in young contrails. The effect of the radiative properties of the four types of ice particles on the Stokes parameters I, Q, U, and V is also investigated for different viewing zenith angles and relative azimuth angles with a solar zenith angle of 301 using a vector radiative transfer model based on the adding-doubling technique. The Stokes parameters at a wavelength of 0.65mm show pronounced differences for the four types of ice crystals, whereas the counterparts at a wavelength of 2.13mm show similar variations with the viewing zenith angle and relative azimuth angle. However, the values of the results for the two wavelengths are noticeably different.",
        "keywords": [
            "optical properties ice particles contrails",
            "zenith",
            "particle size distribution",
            "radiative transfer",
            "black carbon",
            "crystals",
            "radiative transfer model",
            "mathematical models"
        ],
        "authors": [
            {
                "name": "Gang Hong",
                "org": ""
            },
            {
                "name": "Qian Feng",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "George W. Kattawar",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Patrick Minnis",
                "org": "NASA Langley Research Center, Hampton, VA 23681, USA"
            },
            {
                "name": "Yong X. Hu",
                "org": "NASA Langley Research Center, Hampton, VA 23681, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy and Radiative Transfer",
        "year": 2008
    },
    "mSvUMwWh": {
        "id": "mSvUMwWh",
        "title": "An algorithm using visible and 1.38-/spl mu/m channels to retrieve cirrus cloud reflectances from aircraft and satellite data",
        "abstract": "",
        "keywords": [
            "water vapor",
            "information retrieval",
            "atmosphere",
            "reflectivity",
            "satellites",
            "imaging",
            "hyperspectral imaging",
            "remote sensing",
            "data collection",
            "image resolution",
            "algorithm"
        ],
        "authors": [
            {
                "name": "bocai gao",
                "org": "united states naval research laboratory"
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "wei han",
                "org": ""
            },
            {
                "name": "rongrong li",
                "org": ""
            },
            {
                "name": "warren j wiscombe",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Geoscience and Remote Sensing",
        "year": 2002
    },
    "OFCJ55tG": {
        "id": "OFCJ55tG",
        "title": "Effect of black carbon on dust property retrievals from satellite observations",
        "abstract": "",
        "keywords": [
            "particles",
            "reflectivity",
            "carbon",
            "scattering",
            "satellites"
        ],
        "authors": [
            {
                "name": "t lin",
                "org": "national central university"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "bingqi yi",
                "org": "texas a m university"
            }
        ],
        "venue": "Journal of Applied Remote Sensing",
        "year": 2013
    },
    "3D0zmaop": {
        "id": "3D0zmaop",
        "title": "Impact of Ice Cloud Microphysics on Satellite Cloud Retrievals and Broadband Flux Radiative Transfer Model Calculations",
        "abstract": "AbstractIce cloud particles exhibit a range of shapes and sizes affecting a cloud\u2019s single-scattering properties. Because they cannot be inferred from passive visible/infrared imager measurements, assumptions about the bulk single-scattering properties of ice clouds are fundamental to satellite cloud retrievals and broadband radiative flux calculations. To examine the sensitivity to ice particle model assumptions, three sets of models are used in satellite imager retrievals of ice cloud fraction, thermodynamic phase, optical depth, effective height and particle size, and in top-of-atmosphere and surface broadband radiative flux calculations. The three ice particle models include smooth hexagonal ice columns (SMOOTH), roughened hexagonal ice columns, and a two-habit model (THM) comprised of an ensemble of hexagonal columns and 20-element aggregates. While the choice of ice particle model has a negligible impact on daytime cloud fraction and thermodynamic phase, the global mean ice cloud optical depth retri...",
        "keywords": "",
        "authors": [
            {
                "name": "Norman G. Loeb",
                "org": " NASA Langley Research Center, Hampton, Virginia"
            },
            {
                "name": "Ping Yang",
                "org": " Department of Atmospheric Sciences, Texas A&M University, College Station, Texas"
            },
            {
                "name": "Fred G. Rose",
                "org": " Science Systems and Applications, Inc., Hampton, Virginia"
            },
            {
                "name": "Gang Hong",
                "org": " Science Systems and Applications, Inc., Hampton, Virginia"
            },
            {
                "name": "Sunny Sun-Mack",
                "org": " Science Systems and Applications, Inc., Hampton, Virginia"
            },
            {
                "name": "Patrick Minnis",
                "org": " NASA Langley Research Center, Hampton, Virginia"
            },
            {
                "name": "Seiji Kato",
                "org": " NASA Langley Research Center, Hampton, Virginia"
            },
            {
                "name": "Seung-Hee Ham",
                "org": " Science Systems and Applications, Inc., Hampton, Virginia"
            },
            {
                "name": "William L. Smith",
                "org": " NASA Langley Research Center, Hampton, Virginia"
            },
            {
                "name": "Souichiro Hioki",
                "org": " Department of Atmospheric Sciences, Texas A&M University, College Station, Texas"
            },
            {
                "name": "Guanglin Tang",
                "org": " Department of Atmospheric Sciences, Texas A&M University, College Station, Texas"
            }
        ],
        "venue": "Journal of Climate",
        "year": 2017
    },
    "d9qs9s9I": {
        "id": "d9qs9s9I",
        "title": "Variation of the radiative properties during black carbon aging: theoretical and experimental intercomparison",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "chunyuan he",
                "org": ""
            },
            {
                "name": "k n liou",
                "org": ""
            },
            {
                "name": "y takano",
                "org": ""
            },
            {
                "name": "r zhang",
                "org": "texas a m university"
            },
            {
                "name": "m levy zamora",
                "org": "texas a m university"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "qingchun li",
                "org": ""
            },
            {
                "name": "l r leung",
                "org": "pacific northwest national laboratory"
            }
        ],
        "venue": "Atmospheric Chemistry and Physics",
        "year": 2015
    },
    "2hZo1wFx": {
        "id": "2hZo1wFx",
        "title": "A stochastic model for density-dependent microwave Snow- and Graupel scattering coefficients of the NOAA JCSDA community radiative transfer model",
        "abstract": "Abstract   A structural model is developed for the single-scattering properties of snow and graupel particles with a strongly heterogeneous morphology and an arbitrary variable mass density. This effort is aimed to provide a mechanism to consider particle mass density variation in the microwave scattering coefficients implemented in the Community Radiative Transfer Model (CRTM). The stochastic model applies a bicontinuous random medium algorithm to a simple base shape and uses the Finite-Difference-Time-Domain (FDTD) method to compute the single-scattering properties of the resulting complex morphology.",
        "keywords": "",
        "authors": [
            {
                "name": "Patrick G. Stegmann",
                "org": "Department of Atmospheric Sciences, Texas A&M University, 3150 TAMU, College Station, TX77840, USA"
            },
            {
                "name": "Guanglin Tang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, 3150 TAMU, College Station, TX77840, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, 3150 TAMU, College Station, TX77840, USA"
            },
            {
                "name": "Benjamin T. Johnson",
                "org": "NOAA Center for Weather and Climate Prediction, 5830 University Research Ct, College Park, MD20740, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2018
    },
    "OdOmEGKD": {
        "id": "OdOmEGKD",
        "title": "The Influence of Water Coating on the Optical Scattering Properties of Fractal Soot Aggregates",
        "abstract": "",
        "keywords": [
            "cross section"
        ],
        "authors": [
            {
                "name": "chao liu",
                "org": "texas a m university"
            },
            {
                "name": "r lee panetta",
                "org": "texas a m university"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            }
        ],
        "venue": "Aerosol Science and Technology",
        "year": 2011
    },
    "hJHxwTly": {
        "id": "hJHxwTly",
        "title": "Assessing the accuracy and efficiency of longwave radiative transfer models involving scattering effect with cloud optical property parameterizations",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Chia-Pang Kuo",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station , TX, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station , TX, USA"
            },
            {
                "name": "Xianglei Huang",
                "org": "Department of Climate and Space Sciences and Engineering, University of Michigan, Ann Arbor MI, USA"
            },
            {
                "name": "Yi-Hsuan Chen",
                "org": "Department of Climate and Space Sciences and Engineering, University of Michigan, Ann Arbor MI, USA"
            },
            {
                "name": "Guosheng Liu",
                "org": "Department of Earth,  Ocean and Atmospheric Science,  Florida State University,  Tallahassee,  FL,  USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2019
    },
    "8JvehrYU": {
        "id": "8JvehrYU",
        "title": "Erratum to: \u201cModeling of the scattering and radiative properties of nonspherical dust-like aerosols\u201d [J. Aerosol Sci. 38 (2007) 995\u20131014]",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Qian Feng",
                "org": ""
            },
            {
                "name": "Gang Hong",
                "org": ""
            },
            {
                "name": "George W. Kattawar",
                "org": ""
            },
            {
                "name": "Warren J. Wiscombe",
                "org": ""
            },
            {
                "name": "Michael I. Mishchenko",
                "org": ""
            },
            {
                "name": "Oleg Dubovik",
                "org": ""
            },
            {
                "name": "Istvan Laszlo",
                "org": ""
            },
            {
                "name": "Irina N. Sokolik",
                "org": ""
            }
        ],
        "venue": "Journal of Aerosol Science",
        "year": 2010
    },
    "0mjovIit": {
        "id": "0mjovIit",
        "title": "Radiative properties of cirrus clouds in the infrared (8\u201313\u03bcm) spectral region",
        "abstract": "Atmospheric radiation in the infrared (IR) 8\u2013 13 \u03bcm spectral region contains a wealth of information that is very useful for the retrieval of ice cloud properties from aircraft or space-borne measurements. To provide the scattering and absorption properties of nonspherical ice crystals that are fundamental to the IR retrieval implementation, we use the finite-difference time-domain (FDTD) method to solve for the extinction efficiency, single-scattering albedo, and the asymmetry parameter of the phase function for ice crystals smaller than 40 \u03bcm . For particles larger than this size, the improved geometric optics method (IGOM) can be employed to calculate the asymmetry parameter with an acceptable accuracy, provided that we properly account for the inhomogeneity of the refracted wave due to strong absorption inside the ice particle. A combination of the results computed from the two methods provides the asymmetry parameter for the entire practical range of particle sizes between 1 and 10,000 \u03bcm over the wavelengths ranging from 8 to 13 \u03bcm . For the extinction and absorption efficiency calculations, several methods including the IGOM, Mie solution for equivalent spheres (MSFES), and the anomalous diffraction theory (ADT) can lead to a substantial discontinuity in comparison with the FDTD solutions for particle sizes on the order of 40 \u03bcm . To overcome this difficulty, we have developed a novel approach called the stretched scattering potential method (SSPM). For the IR 8\u2013 13 \u03bcm spectral region, we show that SSPM is a more accurate approximation than ADT, MSFES, and IGOM. The SSPM solution can be further refined numerically. Through a combination of the FDTD and SSPM, the extinction and absorption efficiencies are computed for hexagonal ice crystals with sizes ranging from 1 to 10,000 \u03bcm at 12 wavelengths between 8 and 13 \u03bcm . Calculations of the cirrus bulk scattering and absorption properties are performed for 30 size distributions obtained from various field campaigns for midlatitude and tropical cirrus cloud systems. Ice crystals are assumed to be hexagonal columns randomly oriented in space. The bulk scattering properties are parameterized through the use of second-order polynomial functions for the extinction efficiency and the single-scattering albedo and a power-law expression for the asymmetry parameter. We note that the volume-normalized extinction coefficient can be separated into two parts: one is inversely proportional to effective size and is independent of wavelength, and the other is the wavelength-dependent effective extinction efficiency. Unlike conventional parameterization efforts, the present parameterization scheme is more accurate because only the latter part of the volume-normalized extinction coefficient is approximated in terms of an analytical expression. After averaging over size distribution, the single-scattering albedo is shown to decrease with an increase in effective size for wavelengths shorter than 10.0 \u03bcm whereas the opposite behavior is observed for longer wavelengths. The variation of the asymmetry parameter as a function of effective size is substantial when the effective size is smaller than 50 \u03bcm . For effective sizes larger than 100 \u03bcm , the asymmetry parameter approaches its asymptotic value. The results derived in this study can be useful to remote sensing studies of ice clouds involving IR window bands. Keywords Cirrus Crystal Infrared 1 Introduction Cirrus clouds form a unique component of the atmosphere and significantly regulate the Earth's radiation energy budget [1\u20133] because of their large spatial coverage and temporal persistence. And yet, the radiative forcing of these clouds is far from being well understood because of the wide range of observed cirrus cloud properties such as height, optical thickness, particle size, and habit. With the recognition of the importance of cirrus clouds, a number of programs have been established to investigate global cirrus properties. For instance, intensive field observations regarding cirrus clouds have been conducted as a major component of the First ISCCP Regional Experiment (FIRE) (Phase-I in October 1986 and Phase-II in November\u2013December 1991) [4] , the European experiments on cirrus (ICE/EUCREX) carried out in 1989 [5] . Additional cirrus field campaigns are being planned, such as the Cirrus Regional Study of Tropical Anvils and Cirrus Layers (CRYSTAL). Besides these field campaigns, new instrumentation has been developed for use in space- or aircraft-borne measurement programs. Such programs include the Lidar In-space Technology Experiment (LITE) [6] , the MODerate resolution Imaging Spectrometer (MODIS) [7] , and the future Pathfinder Instruments for Cloud and Aerosol Spaceborne Observations-Climatologie Etendue des Nuages et des Aerosols (PICASSO-CENA) [8] . The data obtained from these instruments will enhance our capability to detect cirrus clouds and to retrieve their microphysical and optical properties on a global scale with a substantial temporal span. A number of studies have proposed methods to infer global cirrus properties from infrared (IR) radiance measurements. One benefit to using IR methods to infer cloud properties rather than those that incorporate visible or near-infrared bands is that cloud properties are more consistent between daytime and nighttime conditions. The IR techniques are also independent of the sun glint associated with the specular reflection over water which is prevalent in daytime data. The IR CO 2 slicing technique is effective in inferring cirrus height and effective cloud amount (emittance multiplied by cloud fraction) [9,10] . Various IR algorithms to infer cirrus particle size have been suggested (see e.g., Refs. [11,12] ), whereas the methods to infer cloud thermodynamic phase using data from the 8.52, 11, and 12 \u03bcm bands have been demonstrated by Strabala et al. [13] and Baum et al. [14] . There have been advances in recent years in the development and use of well-calibrated aircraft-based interferometers, such as the High Spectral Resolution Infrared Spectrometer (HIS) [15\u201317] and the National Polar Orbiting Operational Environmental Satellite System (NPOESS) Aircraft sounding Testbed-Interferometer (NAST-I) [18] . In coming years, the spectral resolution of IR data measured from space will increase greatly when interferometers are launched, such as Infrared Atmospheric Sounder Interferometer (IASI) on EUMETSAT, the Geostationary Imaging Fourier Transform Spectrometer (GIFTS), and the NPOESS Crosstrack Infrared Sounder (CRIS). With an interferometer, cloud measurements may be recorded at thousands of wavenumbers simultaneously. To date, however, few studies have explored the use of infrared interferometer data for cirrus cloud property retrieval. The remote sensing of cirrus cloud properties from IR interferometer data has been hampered by the difficulty in determining accurately the fundamental bulk scattering properties for a realistic range of crystal sizes and shapes at IR wavelengths where the applicability of the ray-tracing method breaks down [19] . Cirrus clouds are composed of almost exclusively nonspherical ice crystals, as is evident from the observations based on aircraft-borne two-dimensional optical cloud probes (2D-C) and balloon-borne replicator images (e.g., Refs. [20,21] ). It has been shown that the spherical approximation for nonspherical ice crystals in terms of equivalent volume or projected-area is inadequate and often misleading, as is illustrated by Liou et al. [22] . In practice, an incorrect specification of the ice crystal model in retrieving the optical thickness of cirrus clouds from satellite-borne measurements can lead to an underestimation or overestimation of the actual optical thickness by a factor that can exceed 3 [23] . Thus nonsphericity of ice crystals must be accounted for in the development of a reliable retrieval algorithm. On this specific issue, the significance of using reliable single-scattering properties of ice crystals to generate look-up tables for retrieval implementation and the parameterization of the bulk radiative properties of cirrus clouds has been demonstrated and articulated in a number of recent publications (e.g., Refs. [14,24\u201333] ). Although substantial progress has been made in the study of scattering and absorption by ice crystals [24,34] , there is not a single method that can cover the entire size parameter spectrum for light scattering computations. To derive the scattering and absorption properties of nonspherical ice crystals, Liou et al. [22] developed the concept of a unified theory. This unified theory is based on a combination of a numerically accurate finite-difference time-domain technique (FDTD) [35\u201340] for small particles and an improved geometric optics method (IGOM) [41,42] for large particles at visible and near-infrared wavelengths. However, for IR wavelengths where strong absorption is involved, there is a discontinuity between the FDTD and IGOM results at size parameters on the order of 20, which is in practice the computational limit for the FDTD method given current computer resources. One cause of this discontinuity is the tunneling or the above-edge effect [43] . Several approximate methods [29,30,44,45] suggested to account for the tunneling effect are based on parameterizations involving Mie theory, a combination of Mie theory and the geometric optics method, or the complex angular momentum theory developed by Nussenzveig and Wiscombe [46,47] . The intent of this study is to develop methodology capable of deriving the fundamental scattering and absorption properties of nonspherical ice crystals, specifically hexagonal columns, that span a size range of 1 to 10,000 \u03bcm , over a wavelength range from 8 to 13 \u03bcm . Absorption effects in ice crystals can be appreciable in this IR wavelength range. In Section 2 , we present methodology for calculating the scattering properties at infrared wavelengths. In particular, we present the stretched scattering potential method (SSPM) to calculate the extinction and absorption cross sections. In Section 3 , we present the bulk radiative properties and parameterization for cirrus clouds. Finally, the conclusions of this study are given in Section 4 . 2 Computation of optical properties for ice crystals at infrared wavelengths 2.1 Aspect ratio for ice crystals and selection of wavelengths A variety of nonspherical ice crystal habits, or shapes, have been observed in cirrus clouds, including hexagonal columns and plates, bullet rosettes, and complex aggregates. To demonstrate our methodology, in this study we simplify the complexity of determining what best represents the habit distribution in cirrus by assuming cirrus are composed solely of hexagonal columns with random orientations in space. It should be pointed out that the scattering properties for columns and plates can be substantially different; in particular, it has been shown that the tunneling contributions for hexagonal plates are much smaller than for columns [48] . Although the percentage of pristine ice clouds in cirrus clouds are normally low [49] , studies of in situ cirrus measurements have demonstrated that the upper layers of midlatitude cirrus cloud systems are often comprised of pristine hexagonal crystals [50] . Hexagonal ice crystals are capable of producing 22\u00b0 and 46\u00b0 halos and other optical phenomena by scattering incident solar radiation at short wavelengths. The hexagonal shape model has been assumed often in previous studies concerning cirrus clouds [24\u201330,51\u201353] . Upwelling radiances in the infrared wavelengths tend to be dominated by thermal emission from the uppermost portions of the cloud because the contributions from lower cloud portions are largely absorbed, provided the cloud is not very thin. To carry out scattering calculations, we define the aspect ratio for ice crystals at various sizes as follows: (1) 2a/L= 1, L\u2a7d40 \u03bcm , exp [\u22120.017835(L\u221240)], 40<L\u2a7d50 \u03bcm , 5.916/L 1/2 , L>50 \u03bcm , where a is the semi-width of cross section and L is the length of an ice crystal. The aspect ratio defined by Eq. (1) roughly corresponds to the observations reported by Ono [54] and Auer and Veal [55] . Fig. 1 shows a comparison of the aspect ratio defined in this study with that of Takano and Liou [51] , who used only five size-bins in discretizing the size distribution for ice crystals. Excellent agreement is evident for the comparison. In the D \u2013 L plot of Fig. 1 in which D =2 a is the width of cross section, the continuous D \u2013 L is not smooth at a size of L=40 \u03bcm because of an abrupt variation in the derivative of aspect ratio. However, this effect is very small. To economize the computational effort, the scattering calculations are performed for 12 wavelengths between 8 and 13 \u03bcm , which are selected at 8.0, 8.5, 9.0, 9.5, 10.0, 10.5, 10.8, 11.0, 11.5, 12.0, 12.5, and 13.0 \u03bcm . The choice of these wavelengths is based on the characteristics of ice refractive index compiled by Warren [56] , as is shown in Fig. 2 . The dotted vertical lines indicate the locations of the selected wavelengths. Note that the variation of the refractive index is essentially linear in the intervals of the selected wavelengths. Because of the quasi-linear variation of the refractive index versus wavelength in a given small spectral interval, the scattering and absorption properties at any arbitrary wavelength in the 8\u2013 13 \u03bcm region can be approximated by an interpolation of those calculated at the selected wavelengths. We also note that near 10.8 \u03bcm there exists a region of extremely strong absorption, often called by Christiansen band [57,58] . Near 10.8 \u03bcm , the real part of the refractive index has a value close to 1 and the extinction efficiency reaches a minimum. As is evident from Fig. 2 , the imaginary part of the refractive index is significant at the Christiansen band, leading to the dominance of the absorption effect in the extinction process. The behavior of ice absorption in the Christiansen band has been shown in laboratory measurements [58,59] and a theoretical explanation was reported by Yang et al. [60] . 2.2 Asymmetry parameter for angular distribution of scattered energy The angular distribution of the energy scattered by a particle is defined by its scattering phase function. At IR wavelengths, the phase function of an ice crystal is essentially featureless when compared to that at a visible or near-infrared wavelength. The primary scattering features of a hexagonal crystal at a visible wavelength, such as the halo peaks and backscattering enhancement, are smoothed out at IR wavelengths because of absorption. For radiative transfer calculations at IR wavelengths, the detailed information of the phase function is unnecessary because the multiple scattering effect is only on the order of a few percent. Thus, the asymmetry parameter that describes the magnitude of the deviation of particle phase function from isotopic scattering is very useful at IR wavelengths, which is defined as follows: (2) g= 1 2 \u222b 0 \u03c0 P(\u03b8) cos \u03b8 sin \u03b8 d \u03b8, where P ( \u03b8 ) is the normalized phase function. Given the asymmetry factor associated with an IR phase function of nonspherical ice crystals, an accurate phase function for a given size distribution of ice crystals can be approximated by the well-known Henyey\u2013Greenstein analytical function (3) P HG (\u03b8)= 1\u2212g 2 (1+g 2 \u22122g cos \u03b8) 3/2 = \u2211 l=0 N (2l+1)g l P l ( cos \u03b8), where P l ( cos \u03b8) is the set of Legendre polynomials employed for the decomposition of the phase function. The advantage of using the Henyey\u2013Greenstein phase function in radiative transfer calculations lies in its simplicity and efficiency in the expansion of a phase function in terms of Legendre function. There is a physical justification for such a simplification. For an IR wavelength, the phase function calculated for a given size distribution of ice crystals tends to be smooth at sidescattering and backscattering angles whereas a strong diffraction peak is typically noted in the forward scattering direction. The forward peak may need to be truncated; for this the delta-M method developed by Wiscombe [61] may be employed. The truncated phase function can be well approximated by the analytical Henyey\u2013Greenstein function at the IR wavelengths relevant to our study. The FDTD technique is employed to solve for the scattering and absorption properties for ice crystals whose maximum dimensions are smaller than 40 \u03bcm . The FDTD method solves the interaction of electromagnetic waves with a particle of any given shape and is based on the finite-difference analog of the time-dependent Maxwell equations. The strength of this method is its simplicity in concept, computational flexibility, and robust nature in dealing with light scattering problems involving nonspherical and/or inhomogeneous particles. The disadvantage of this method is its tremendous demand on computational resources when the size parameter is larger than 20. Detailed descriptions of the FDTD method may be found in Yang and Liou [38] . To calculate the asymmetry parameter for ice crystals larger than 40 \u03bcm , we use a hybrid method based on the improved geometric optics principle (IGOM) and the electromagnetic integral equations [41,42] . At IR wavelengths, the refractive wave inside an ice crystal is inhomogeneous because the planes of constant phase are not parallel to the planes of constant amplitude [62] . This inhomogeneity affects both the ray direction and the reflection/refraction components at the air\u2013particle interface [35] . In particular, the Fresnel coefficients are not unique when absorption is involved, as was shown recently by Yang et al. [63] , who further determined the proper form of the reflection/refraction coefficients that should be used in ray-tracing calculations. We have accounted for this improvement in the present set of scattering calculations. Fig. 3 shows the asymmetry parameter calculated by the FDTD and the IGOM over a range of ice crystal sizes at wavelengths 8.5, 11, and 12 \u03bcm . The radiative information at these three wavelengths are being used to retrieve cloud thermodynamic phase in MODIS data. For comparison of results between spherical and nonspherical particles, results computed from Mie theory for equivalent ice spheres are provided in Fig. 3 . Following work by Francis et al. [5] , Mitchell and Arnott [64] , Fu et al. [29] , Yang et al. [65] , and Grenfell and Warren [66] , we define the radius of the equivalent sphere for an individual hexagonal ice crystal as follows: (4) r e = 3 4 volume projected-area = 3 4 3 a 2 L 3 a 2 /2+aL , where a and L are the semi-width and the length of ice crystal, respectively. The advantage of the preceding definition over those for equivalent volume (or projected-area) is that both volume and area are conserved in approximating the nonspherical particle in terms of a polydisphere system of the equivalent spheres. The inserted subdiagrams in Fig. 3 provide enlargements for ice crystal sizes of 1\u2013 40 \u03bcm . For small ice crystals with sizes of 3\u2013 9 \u03bcm , the asymmetry parameters computed from Mie theory for the equivalent spheres and the FDTD technique for the nonspherical particles are quite different. For sizes larger than 100 \u03bcm , the IGOM results essentially converge to the Mie results. This convergence occurs because the rays refracted into the particles are almost entirely absorbed and the diffraction and external reflection contributions dominate the scattered energy. Under random orientation conditions, diffraction and external reflection are not sensitive to the details of particle shape. From Fig. 3 , we note that the FDTD results and IGOM solutions converge at a particle size of 40 \u03bcm . Although the absolute amount of scattered and absorbed energy calculated by IGOM can have a substantial error for moderate particle sizes on the order of 40 \u03bcm or less, the IGOM can be used to predict the relative angular distribution of scattered energy. Thus, the normalized IGOM phase function can be a good approximation. From this physical rationale and the numerical results shown in Fig. 3 , the concept of the unified theory developed by Liou et al. [22] can also be applied to the computation of the asymmetry parameter. Therefore, in this study we combine the FDTD solution (for sizes smaller than 40 \u03bcm ) and IGOM results (for sizes larger than 40 \u03bcm ) for the asymmetry factor so that the entire size spectrum can be covered. Fig. 4 shows merged FDTD/IGOM results for the asymmetry factor for the 12 wavelengths for particle sizes of 1\u2013 10,000 \u03bcm . The variation of the asymmetry factor with the particle size displays a minimum at 30 \u03bcm for wavelengths 8.0, 8.5 and 9.0 \u03bcm where the absorption of ice is moderate. This minimum vanishes for longer wavelengths. The overall feature of the asymmetry parameter is that the g values are close to unity for large sizes because diffraction dominates the scattered energy which is concentrated in forward direction. For all 12 wavelengths, there is a substantial increase in the value of the asymmetry parameter as the size of the particle increases from 1 to 40 \u03bcm . For sizes larger than 40 \u03bcm , the asymmetry parameter essentially reaches an asymptotic value. 2.3 Stretched scattering potential method for computing extinction and absorption cross sections for nonspherical particles Several methods exist to calculate extinction and absorption cross sections for nonspherical particles. To date, the upper limit of the size parameter region for which one can obtain the exact solution for the scattering properties of certain nonspherical particles is on the order of 200. This limitation is for axisymmetrical particles such as spheroids, finite circular cylinders, and the so-called Chebyshev particles [67] , as solved by the T -matrix method [68] . The applicable size parameter regimes for other exact methods to solve the scattering properties of nonspherical particles are normally smaller than that associated with the T -matrix method. For a nonaxisymmetrical particle, the size parameter region for which an exact solution may be obtained is substantially reduced. For instance, the limitation on size parameter for the T -matrix method is on the order of 40 when it is applied to hexagonal particles [A. Baran, personal communication]. The FDTD and its counterpart, the discrete dipole approximation (DDA) [69,70] , encounter computational difficulties for size parameters larger than 20. For these reasons, use of an approximate method is necessary in practice. The anomalous diffraction theory (ADT) developed by van de Hulst [71] has been widely used to calculate the extinction and absorption cross sections for nonspherical particles [72\u201374] . Unfortunately, ADT leads to substantial errors if the refractive index of the particles is not close to 1. In particular, ADT fails to account for the tunneling effect; the absorption efficiency calculated from ADT cannot be larger than 1. The intent of this section is to derive an improved approximate method to calculate the extinction and absorption cross sections. The wave equation derived from the Maxwell equations can be written as (5) ( \u2207 2 +k 2 ) E \u0304 ( r \u0304 )=\u2212U( r \u0304 ) E \u0304 ( r \u0304 ), where U( r \u0304 )=[m 2 ( r \u0304 )\u22121]k 2 in which m is the complex refractive index of the medium and k is the wavenumber in a vacuum. Through comparison of Eq. (5) to the standard Schr\u00f6dinger equation in quantum mechanics, we can regard U( r \u0304 ) as a scattering potential. Thus, the light scattering problem can be treated as one concerning the interaction of photons and a potential. The separation of variables method (cf. Ref. [34] ) can be used to solve Eq. (5) exactly but is limited to only a few particle shapes such as spheres and spheroids. In practice, the high-energy approximation (HEA) [75\u201377] and ADT can be used to solve Eq. (5) approximately. These methods are the eikonal type [78] in which rectilinear projectiles are assumed for the propagation of photons, with (or without) deviation only at the places where the scattering potential vanishes, i.e., at the particle surface. Thus, in these conventional approximations, the nonzero-interaction region is where wave function undergoes phase delay and absorption and is limited inside the particle. Recently, Fu et al. [30] have computed the Poynting vector for the near-field associated with the scattering of IR radiation by a hexagonal ice crystal to illustrate the flow of electromagnetic energy around the particle. It is shown that the incident Poynting stream outside the geometric projected area of the particle can deviate and be traced through the particles, a phenomenon otherwise known as the tunneling or the above-edge effect. Although HEA and ADT provide a good physical insight in concept and a simple mathematical formulation in practice, they may produce significant errors in computation, e.g., a substantial underestimation of absorption efficiency in the resonance region because of the failure to account for the tunneling effect. To avoid this shortcoming of the conventional eikonal-type approximation that is applied to solve Eq. (5) , it is necessary to stretch the scattering potential to account for the tunneling effect. Fig. 5 (a) illustrates the region of non-null scattering potential, where the interaction of photons and medium occurs for the conventional eikonal methods. The scattering potential U( r \u0304 ) is nonzero only inside the particles for the conventional methods. Fig. 5 (b) is the conceptual diagram for the present stretched scattering potential method (SSPM), where a is the physical size of the particle and \u0394 a is extension for the stretched potential. In this method, the scattering potential U( r \u0304 ) is stretched so that the nonzero effect region for photon propagation extends outside the physical volume of the scattering particle. We assume the scattering potential has a quadratic distribution, for example, in the spherical particle case, as follows: (6) U(r)= (m 2 \u22121)k 2 , r\u2a7da, (m 2 \u22121)k 2 [1\u2212(r\u2212a)/ \u0394 a] 2 , a<r\u2a7da+ \u0394 a, 0, r\u2a7ea+ \u0394 a. For stretched scattering potential in the region between a and a +\u0394 a , we can define an effective refractive index m \u0303 =( m \u0303 r +i m \u0303 i ) given by (7) m \u0303 2 \u22121=(m 2 \u22121)[1\u2212(r\u2212a)/ \u0394 a] 2 . The solution of Eq. (7) is (8a) \u03b1=1+(m r 2 \u2212m i 2 \u22121)[1\u2212(r\u2212a)/ \u0394 a] 2 , (8b) \u03b2=m r m i [1\u2212(r\u2212a)/ \u0394 a] 2 , (8c) m \u0303 r (r)=[\u03b1+(\u03b1 2 +4\u03b2 2 ) 1/2 ]/2 and (8d) m \u0303 i (r)=\u03b2/ m \u0303 r (r). The external reflection and multiple internal reflections and subsequent transmission of the wave is completely neglected in the conventional eikonal-type approximate methods to solve Eq. (5) . The result of ignoring these effects is equivalent to an overestimation of scattering potential. To include the external and internal reflection/transmission effect equivalently, the scattering potential should be compressed instead of being stretched. The compressed scattering potential is given in the form of (9) U(r)= (m 2 \u22121)k 2 , r\u2a7da\u2212 \u0394 a, (m 2 \u22121)k 2 [1\u2212(r\u2212a+ \u0394 a)/ \u0394 a] 2 , a\u2212 \u0394 a<r\u2a7da, 0, r\u2a7ea. Fig. 6 shows the concept of using an eikonal approximation in the ADT framework to calculate the extinction and absorption cross sections for a spherical particle. In practice, continuous variation of the effective refractive index is discretized as various layers. That is, the effect of stretching the scattering potential is equivalent to adding some dielectric medium layers outside the scattering particle. For a given layer, we calculate the mean effective refractive index as follows: (10) \u3008 m \u0303 r +i m \u0303 i \u3009 j = 1 \u0394 r \u222b r j \u2212 \u0394 r/2 r j + \u0394 r/2 [ m \u0303 r (r)+i m \u0303 i (r) d r, where r j is the radius of the j th layer and \u0394 r is the thickness of the layer. A uniform thickness is assumed for all the layers in the present study. According to the geometry shown in Fig. 6 and the physical assumption in conjunction with Huygen's principle for the ADT approximation [71] , we obtain expressions for the extinction cross section ( \u03c3 ext ) and the absorption cross section ( \u03c3 abs ) for a layered sphere, respectively, as follows: (11a) \u03c3 ext =2 \u222b\u222b P (1\u2212 e \u2212\u03b3 cos \u03c1) d 2 P, (11b) \u03c3 abs = \u222b\u222b P (1\u2212 e \u22122\u03b3 ) d 2 P, where the domain of the integration, P , is the projected area of the particle, and \u03c1 is the phase delay that a photon undergoes in conjuction with its penetration of the multilayered sphere. The phase delay parameter is given by (11c) \u03c1=kd 0 (m r \u22121)+ \u2211 j=1 N k(d j \u2212d j\u22121 )(\u3008 m \u0303 r \u3009 j \u22121), in which d 0 is the length of the photon projectile inside the particle and d i is the length of photon path inside the i th layer, as is shown in Fig. 6 . In Eq. (11c) N is the number of total layers outside the particle. The attenuation factor, \u03b3 , for the damping of the incident wave is given by (11d) \u03b3=kd 0 m i + \u2211 j=1 N k(d j \u2212d j\u22121 )\u3008 m \u0303 i \u3009 j . Eqs. (11c) and (11d) are for the case where the scattering potential is stretched outside the particle. A similar mathematical formulation may be derived for the case when the scattering potential is compressed or reduced. From the preceding discussion of the SSPM approximation, the only tuning parameter is the distance \u0394 a for stretching the scattering potential. The physical processes associated with the extinction and absorption of the incident wave are quite different. For example, the surface wave (a term in the rigorous physical picture) [43,71] that creeps along the particle surface can contribute to the extinction but not to the absorption. This is because the surface waves do not enter the interior of the particle (i.e., they do not undergo absorption), but are responsible for large angle diffraction, as is illustrated by Mitchell [44] . Note that diffraction is a part of extinction process. Therefore, the magnitude of the extension of the scattering potential may be different for calculating the extinction cross section from calculating the absorption cross section. For this reason, we denote \u0394 a as \u0394 a e and \u0394 a a for extinction and absorption calculations, respectively. Fig. 7 shows the values of \u0394 a e that are derived from the best fit of the exact Mie solution using the SSPM results in the spherical case. In this study, the computational Mie code developed by Wiscombe [79] is used. To determine \u0394 a e , a Mie calculation is first carried out; subsequently a Monte Carlo method is employed to determine the proper value for \u0394 a e for the SSPM method. Specifically, for each SSPM calculation in the case where the potential is stretched rather than compressed, we chose (12) \u0394 a e =\u03bea, where \u03be is a random number that is uniformly distributed in [0,1]. From Fig. 7 , it is shown that the magnitude of \u0394 a e increase with particle dimension. However, the ratio of \u0394 a e to the particle dimension reaches a maximum at a particle size of approximately 10 \u03bcm where the resonance effect is largest. As is evident in Fig. 7 , the SSPM extinction efficiency actually overlaps with the Mie solution. If the procedure for calculating \u0394 a e and the extinction efficiency were reversible, the SSPM could reproduce the exact theory, providing that adequate extension of the scattering potential was known a priori. It is straightforward to obtain the correct stretching scattering potential for the SSPM calculation for a spherical particle case because of the availability of the exact Mie theory, as is evident from the results shown in Fig. 7 . For scattering by a nonspherical particle, it is necessary to define an approximation of the correct expansion of the scattering potential. Fig. 8 is similar to Fig. 7 except it relates to the absorption calculation. Again, if \u0394 a a is properly selected, the SSPM result can match the analytical Mie solution. Another feature of the behavior of \u0394 a a as a function of the particle size is that negative values are noted for very large particles. This means that the scattering potential should be compressed in the calculation of absorption cross section because the effect of external reflection and refraction is not accounted for in the eikonal-type approximation given by Eqs. (11a)\u2013(11d) . For the absorption efficiency at 12.0 \u03bcm wavelength, a pronounced tunneling effect can be observed because the absorption efficiency is substantially larger than unity for particle sizes near 10 \u03bcm . The SSPM accounts for the tunneling effect, providing a proper expansion of the scattering potential is used. It is problematic to accurately predescribe the expansion of the scattering potential for SSPM calculation for a nonspherical particle. In this case, we approximate \u0394 a e and \u0394 a a by the values obtained from the equivalent spheres with radii defined by Eq. (4) that conserves both the volume and projected-area in the equivalence process. In the SSPM computation for hexagonal ice crystals, we specifically solve for the phase delay and wave attenuation for a number of layered hexagons. The total number of the hexagonal layers and their thicknesses are approximated by their counterparts in the spherical case. Fig. 9 is a conceptual flow chart for determining the three-dimensional geometry including the region of stretched scattering potential for nonspherical particle for SSPM calculation. As shown in Fig. 9 , we first determine the parameter \u0394 a e (or \u0394 a a ) for the equivalent sphere by matching the SSPM calculation (in spherical case) with the corresponding Mie solution. Subsequently, the stretching parameter \u0394 a e that is obtained for the equivalent sphere is used as a surrogate for nonspherical ice crystals. Evidently, nonsphericity effect is explicitly accounted for in SSPM calculation for ice crystals. Fig. 10 shows the absorption efficiency of hexagonal ice crystals calculated from various methods. The errors of the FDTD results are less than 1% for the typical grid resolution [40] . Thus, the FDTD results here can be used as a reference for checking the accuracy of the approximate methods. As shown in Fig. 10 , the SSPM results essentially overlap with the FDTD solution for wavelengths of 8.0, 8.5, 9.0, 9.5, 10.0, and 10.5 \u03bcm . For longer wavelengths, deviation of the SSPM results from FDTD is noted for particle sizes larger than 20 \u03bcm . It also becomes evident that the GOM, ADT, and MTFES may lead to substantial errors. In particular, ADT will significantly overestimate the absorption efficiency for very large particles when the particles are strongly absorptive at a given wavelength. The asymptotic value for ADT absorption efficiency is unity because the external reflection is unaccounted for in this approximation. The Mie results shown in Fig. 10 are generated for spheres whose radii are defined by Eq. (4) . Fig. 11 is similar to Fig. 10 except that results are shown for extinction efficiency. One obvious result is that Mie theory for the equivalent spheres substantially overestimates the extinction at the resonance maximum. The GOM and ADT methods converge for large particles. The GOM results shown here are from the improved geometric optics method developed by Yang and Liou [41,42] . If the conventional ray tracing method is used, the extinction efficiency is simply 2 regardless of particle size, as is pointed out by Yang and Liou [35] . For all 12 wavelengths the SSPM results seem to provide the most consistent comparisons with the FDTD method. Some physical processes, such as the external reflection and detailed nonsphericity effects, are not fully accounted for in the SSPM because exact expansion of the potential is not used. The effects associated with these physical processes are reflected in the equivalent Mie and GOM results to some extent. Thus, we can refine the SSPM results as follows: (13) Q refined =(1\u2212\u03b4 1 \u2212\u03b4 2 )Q SSPM +\u03b4 1 Q Mie +\u03b4 2 Q GOM , where Q stands for either extinction efficiency Q e or absorption efficiency Q a . The values of the parameters \u03b4 1 and \u03b4 2 are so determined that the Q refined best fit the FDTD results for crystal sizes between 20 and 40 \u03bcm . It is found that the parameters \u03b4 1 and \u03b4 2 in Eq. (3) are strongly dependent on wavelength. For example, the weighting coefficients for the SSPM, Mie, and GOM solutions in Q a calculation are (1\u2212 \u03b4 1 \u2212 \u03b4 2 , \u03b4 1 , \u03b4 2 )=(0.186,0.2036,0.6104) and (0.6641,0.0042,0.3317) for 10.5 and 12.5 \u03bcm , respectively. The corresponding values for Q e calculation are (0.6880,0.0,0.3120) and (0.6160,0.0004,0.3836). The refined SSPM results are given only for sizes larger than 20 \u03bcm , because the geometric optics solution involved in Eq. (13) is essentially meaningless due to the failure of the localization principle for small size parameters. Fig. 12 shows the refined SSPM results for the extinction and absorption cross section efficiencies. With this refinement, calculations can be provided for the entire size spectrum. The refinement procedure employed here is similar to that used by Fu et al. [29] who use a weighted summation of Mie and IGOM solutions to obtain an approximate fit for the single-scattering properties of hexagonal ice crystals. 3 Application to cirrus clouds and parameterizations To derive a set of ice crystal bulk scattering properties for practical applications, it is necessary to derive the single-scattering properties using realistic particle size distributions. In this study, we select the 28 size distributions used by Fu [28] with an additional two datasets from Mitchell et al. [80] . These size distributions were measured for a variety of midlatitude and tropical cirrus clouds and were obtained during various field campaigns including the Central Equatorial Pacific Experiment (CEPEX) [81] . McFarquhar et al. [82] showed that the microphysical properties of ice crystals for tropical cirrus clouds are quite different from those for midlatitude cirrus systems. It is common to characterize the bulk properties of a size distribution by two parameters\u2014ice water content ( IWC ) and effective size. For a given size distribution, IWC is defined as follows: (14) IWC=\u03c1 ice \u222b L min L max V(L)n(L) d L, where \u03c1 ice is the mass density of bulk ice, n ( L ) is particle number density, V ( L ) is the volume of an ice crystal at bulk ice density with maximum dimension of L , and L min and L max are the minimum and maximum sizes in the size distributions, respectively. There are many definitions for effective size in the literature. Wyser and Yang [31] performed a comprehensive comparison of definitions commonly used in different parameterization efforts. In this study, we define the effective size following Foot [83] , Francis et al. [5] , Fu [28] , Wyser and Yang [31] , and Grenfell and Warren [66] as (15) D e = 3 2 \u222b L min L max V(L)n(L) d L \u222b L min L max A(L)n(L) d L , where A ( L ) is the projected-area of the particle with size of L . The preceeding definition reduces to that defined by Hansen and Travis [84] for spherical particles. We note that Eq. (15) is similar to Eq. (4) except that only an individual particle is considered in Eq. (4) whereas Eq. (15) considers a size distribution. In addition to the effective size, we also define the mean maximum dimension for a given size distribution as follows: (16) \u3008L\u3009= \u222b L min L max Ln(L) d L \u222b L min L max n(L) d L . Fig. 13 shows a scatterplot for the effective size D e as a function of the mean maximum dimension \u3008 L \u3009 for the aforementioned thirty size distributions described. It is evident that D e is normally larger than \u3008 L \u3009 for a given size distribution. This occurs because the distributions contain a large number of small particles that are significant in defining the mean maximum dimension. However, the contribution of small particles to the total volume or projected-area is relatively small regardless of their contribution . Thus, the largest weight in defining D e is for moderate or large ice crystals. It is also evident from Fig. 13 that the spectrum of effective sizes ranges from approximately 10 to 160 \u03bcm for the selected size distribution datasets. Given the range of effective sizes, the present set of ice cloud size distributions should provide an effective basis for a parameterization effort. It is worth noting that D e depends on ice crystal shapes and sizes when \u3008 L \u3009 is held constant. For a given size distribution of ice crystals, the bulk extinction coefficient is defined as follows: (17) \u03b2 e = \u222b L min L max Q e (L)A(L)n(L) d L. It is convenient in practice to define a volume-normalized extinction coefficient [31] , given by (18) \u03b2 \u0303 e = \u03b2 e (IWC/\u03c1 ice ) = \u222b L min L max Q e (L)A(L)n(L) d L \u222b L min L max V(L)n(L) d L . Note that the quantity ( IWC / \u03c1 ice ) in the preceeding equation provides the total bulk volume of ice crystals for a given size distribution. For a cirrus cloud with a given IWC and geometrical thickness \u0394 z , the dimensionless optical thickness of the cloud may be obtained from (19) \u03c4= \u03b2 \u0303 e IWC \u03c1 ice \u0394 z. This relationship is useful in practice because IWC is now a prognostic parameter in many global climate models (GCMs) [85] . In many parameterization efforts, it is common to parameterize \u03b2 e or \u03b2 \u0303 e as a function of the effective size. In particular, it has been found that the extinction coefficient decreases with an increase in effective size (e.g., Refs. [28,31] ). We suggest that it may be more useful to parameterize the mean extinction efficiency rather than the extinction coefficient. The volume-normalized extinction coefficient \u03b2 \u0303 e can be rewritten exactly as (20) \u03b2 \u0303 e = 3 2D e \u3008Q e \u3009, where \u3008 Q e \u3009 is the mean extinction efficiency that is defined as (21) \u3008Q e \u3009= \u222b L min L max Q e (L)A(L)n(L) d L \u222b L min L max A(L)n(L) d L . From inspection of Eqs. (20) and (21) , we suggest that the accuracy of a parameterization scheme would be improved if the mean extinction efficiency could be parameterized accurately. For visible wavelengths, the size parameter is very large even for small ice crystals on the order of 10 \u03bcm . Thus, for visible wavelengths, the extinction efficiency of an ice crystal essentially approaches a geometric optics asymptotic value of 2 for a realistic set of particle sizes. For the IR region of interest in the present study, the resonance effect is obvious for ice crystal sizes between 10 and 20 \u03bcm . However, the number concentration of particles in this size region may be significant for some ice clouds such as contrails and cold cirrus. Thus, \u3008 Q e \u3009 needs to be investigated carefully in a parameterization effort. From Eq. (20) , the wavelength-dependent part of the extinction coefficient is the mean extinction efficiency. The mean extinction efficiency can be parameterized as a function of effective size. Fig. 14 shows the variation of the volume-normalized extinction coefficient, \u03b2 \u0303 e , as a function of effective size for 12 wavelengths in the IR window region. The extinction coefficient decreases with an increase of effective particle size, as expected from Eq. (20) . For effective particle sizes larger than 80 \u03bcm , the extinction coefficient approaches its asymptotic value with a small variation as particle size increases. We note that \u03b2 \u0303 e can be regarded as the extinction coefficient for a unity IWC because the mass density of ice is independent of the size distribution. For a fixed cloud geometrical thickness and IWC , according to Fig. 14 and Eq. (19) , the cloud will have a larger optical thickness if the ice crystals are small. Conversely, the optical thickness of the cloud will be reduced if the particle sizes are large. The circle symbols in Fig. 15 show the variation of the dimensionless mean extinction efficiency as a function of 1/ D e . The variation pattern of \u3008 Q e \u3009 is shown to have a dependence on wavelength. The magnitude of \u3008 Q e \u3009 ranges between 1.5 and 2.2. When 1/ D e approaches zero (i.e., large effective size), the mean effective extinction efficiency is close to 2. This is expected because the particle extinction efficiency reaches its geometric optics asymptotic value when the size is very large. For wavelengths 8.5,9.0,9.5,10.0,12.0,12.5 and 13.0 \u03bcm , an extinction maximum is observed for the moderate effective sizes. For wavelengths 10.5, 10.8, 11.0, and 11.5 \u03bcm near the Christiansen band, the mean extinction efficiency decreases with the increase of 1/ D e , i.e., a decrease of particle mean size. The mean extinction efficiency may be parameterized by a second-order polynomial in the form of (22) \u3008Q e \u3009=\u03b7 2 (1/D e ) 2 +\u03b7 1 (1/D e )+\u03b7 0 , where the coefficients \u03b7 0 , \u03b7 1 , and \u03b7 2 are determined from the least-squared fitting technique. Table 1 lists the three fitting coefficients derived for the 12 wavelengths. The parameterization results are also shown in Fig. 15 (solid lines). The circle symbols in Fig. 16 show the a variation of single-scattering albedo with 1/ D e . Here the mean value of the single-scattering albedo for a given size distribution is defined as follows: (23) \u3008 \u03c9 \u0303 \u3009= \u222b L min L max [Q e (L)\u2212Q a (L)]A(L)n(L) d L \u222b L min L max Q e (L)A(L)n(L) d L . The overall variation trend of \u3008 \u03c9 \u0303 \u3009 in the IR window region can be grouped into two categories: for wavelengths smaller than 10.0 \u03bcm , the single-scattering albedo increases with an increase of 1/ D e , i.e., single-scattering albedo increases with decreasing mean particle size; for wavelengths longer than 10.5, the opposite behavior is observed. A second-order polynomial function may be employed to fit the single-scattering albedo in the form of (24) \u3008 \u03c9 \u0303 \u3009=\u03b6 2 (1/D e ) 2 +\u03b6 1 (1/D e )+\u03b6 0 . Table 2 lists the fitting coefficients in Eq. (24) . The solid lines in Fig. 16 show the corresponding parameterization results. The circle symbols in Fig. 17 show the asymmetry factor calculated for the 30 size distributions at 12 wavelengths. In this figure, the asymmetry factor is plotted against the effective size rather than against 1/ D e as in Figs. 15 and 16 . The asymmetry factor increases with an increase in the effective size. One explanation for this is that particle absorption reduces the amount of scattered energy in the side scattering and back scattering directions, and affects the transmission of the incident wave. In addition, the diffracted energy is concentrated in a narrower region around the forward scattering direction when the particle sizes are increased. While polynomial functions are employed often to parameterize the asymmetry factor (e.g., Refs. [28,31] ), we suggest instead the use of a power-law form, which may be mathematically expressed as follows: (25) \u3008g\u3009=\u03c2(\u3008D e \u3009) \u03ba . The fitting coefficients \u03c2 and \u03ba for Eq. (25) are listed in Table 3 . Our parameterization results as given by Eqs. (22), (24) and (25) should be limited to the domain of effective sizes (approximately 10\u2013 160 \u03bcm ) used in our analyses. For an effective size outside of this range, the applicability of the parameterization should be checked discreetly to avoid any unpleasant artifacts. 4 Conclusions We present fundamental scattering and absorption properties for hexagonal ice crystal columns with sizes ranging form 1 to 10,000 \u03bcm in the infrared (IR) 8\u2013 13 \u03bcm window region. The 8\u2013 13 \u03bcm region contains a wealth of spectral information that may be beneficial for satellite-borne IR retrieval of ice cloud properties. To obtain scattering and absorption properties over this range of particle sizes, two method need to be employed because there is currently no single-scattering computational method that can cover the entire size parameter spectrum. In this study we use the finite-difference time domain (FDTD) method to solve for the extinction efficiency, single-scattering albedo, and the asymmetry parameter of the phase function for ice crystals smaller than 40 \u03bcm . We find that the improved geometric optics method (IGOM) can be employed to calculate the asymmetry parameter for ice crystals larger than 40 \u03bcm if one accounts for the inhomogeneity effect of the refracted wave inside the nonspherical ice particle. The combination of the two methods provides the results for the entire range of particle sizes over wavelengths ranging from 8 to 13 \u03bcm . Other methods are compared but shortcomings are noted. In particular, methods based on geometric optics and anomalous diffraction theory (ADT) fail to account for the tunneling effect (a phenomenon in which the incident energy stream outside the particle projected-area can be trapped and scattered/absorbed) in calculating the absorption and extinction efficiency. The analytical Mie theory does account for the tunneling effect. When the equivalent spherical approximation is applied to scattering by a nonspherical ice crystal, a significant overestimation of the effect can result. This is a particular problem at the size parameter where the resonance maximum is produced. For the extinction and absorption efficiency calculations, several methods including the IGOM, the Mie solution for equivalent spheres (MSFES), and ADT can lead to a substantial discontinuity at a particle size of 40 \u03bcm . We have developed a novel new approach called the stretched scattering potential method (SSPM) to address the aforementioned difficulties. As 12 wavelengths in the spectral region 8\u2013 13 \u03bcm , we show that the SSPM is a more accurate approximation than ADT, MSFES, and IGOM. Additionally, we suggest numerical refinements to the SSPM solution. Through a combination of the FDTD and SSPM, we have computed the extinction and absorption efficiency for hexagonal ice crystals with sizes ranging from 1 to 10,000 \u03bcm at 12 wavelengths between 8 and 13 \u03bcm . Based on the single-scattering properties obtained for individual ice crystals, 30 size distributions obtained from various field campaigns for midlatitude and tropical cirrus cloud systems have been selected to calculate the bulk scattering/absorption properties for the clouds. A parameterization effort is carried out to provide an analytical representation for these bulk scattering properties. The parameterizations are based on second-order polynomial functions for the extinction efficiency and the single-scattering albedo and a power-law form for the asymmetry parameter. We note that the volume-normalized extinction coefficient can be separated into two parts: one is inversely proportional to effective size and is independent of wavelength, and the other is the mean extinction efficiency. The present parameterization scheme is more accurate than conventional parameterization efforts because only the latter part of the volume-normalized extinction coefficient (i.e., the mean extinction efficiency) is approximated in terms of an analytical expression. Finally, we note that the single-scattering properties of ice crystals in the IR window region show a very strong wavelength dependence. This is particularly true for the single-scattering albedo. Numerical results show that the single-scattering albedo decreases with an increase in particle size for wavelengths shorter than 10.0 \u03bcm ; the opposite pattern is observed for longer wavelengths. The results obtained in this study will be useful for both aircraft- and space-based IR retrieval of ice clouds. 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Theory and computation of multiple scattering in an anisotropic medium J Atmos Sci 46 1989 20 36 [53] E.E. Ebert J.A. Curry A parameterization of ice cloud optical properties for climate models J Geophys Res 97 1992 3831 3836 [54] A. Ono The shape and riming properties of ice crystals in natural clouds J Atmos Sci 26 1969 138 147 [55] A.H. Auer Jr D.L. Veal The dimension of ice crystals in natural clouds J Atmos Sci 27 1970 919 926 [56] S. Warren Optical constants of ice from the ultraviolet to the microwave Appl Opt 23 1984 1206 1225 [57] H.R. Carlon Christiansen effect in IR spectra of soil-derived atmospheric dusts Appl Opt 18 1976 3610 3614 [58] W.P. Arnott Y.Y. Dong J. Hallett Extinction efficiency in the infrared (2\u2013 18 \u03bcm ) of laboratory ice clouds: observations of scattering minima in the Christiansen bands of ice Appl Opt 34 1995 541 551 [59] C.G. Schmitt W.P. Arnott Infrared emission (500\u2013 2000 cm \u22121 ) of laboratory ice clouds JQSRT 63 2000 701 725 [60] P. Yang K.N. Liou W.P. Arnott 1997: Extinction efficiency and single-scattering albedo of ice crystals in laboratory and natural cirrus clouds J Geophys Res 102 1997 21,825 21,835 [61] W.J. Wiscombe The delta-M method: rapid yet accurate radiative flux calculations for strongly asymmetric phase functions J Atmos Sci 34 1977 1408 1422 [62] J.A. Stratton Electromagnetic theory. 1941 McGraw-Hill New York [63] P. Yang B.C. Gao B.A. Baum Y.X. Hu W.J. Wiscombe M.I. Mishchenko D.M. Winker S.L. Nasiri Asymptotic solutions for optical properties of large particles with strong absorption. Appl Opt 40 2001 1532 1547 [64] D.L. Mitchell W.P. Arnott A model predicting the evolution of ice particle size spectra and radiative properties of cirrus clouds. Part II: Dependence of absorption and extinction on ice crystal morphology J Atmos Sci 51 1994 817 832 [65] P. Yang K.N. Liou K. Wyser D. Mitchell Parameterization of the scattering and absorption properties of individual ice crystals J Geophys Res 105 2000 4699 4718 [66] T.C. Grenfell S.G. Warren Representation of a nonspherical ice particle by a collection of independent spheres for scattering and absorption of radiation J Geophys Res 104 1999 31,697 31,709 [67] A. Mugnai W.J. Wiscombe Scattering from nonspherical Chebyshev particles. 1. Cross sections, single-scattering albedo, asymmetry factor, and backscattered fraction Appl Opt 25 1986 1235 1244 [68] M.I. Mishchenko Light scattering by size-shape distributions of randomly oriented axially symmetric particles of a size comparable to a wavelength Appl Opt 32 1993 4652 4666 [69] E.M. Purcell C.R. Pennypacker Scattering and absorption of light by nonspherical dielectric grains Astrophys J 186 1973 705 714 [70] B.T. Draine P.J. Flatau Discrete-dipole approximation for scattering calculations J Opt Soc Am A 11 1994 1491 1499 [71] H.C. van de Hulst Light scattering by small particles 1957 Wiley New York [72] P. Chylek J.D. Klett Extinction cross sections of nonspherical particles in the anomalous diffraction approximation J Opt Soc Am A 8 1991 274 281 [73] Y. Liu W.P. Arnott J. Hallett Anomalous diffraction theory for arbitrarily oriented finite circular cylinders and comparison with exact T -matrix results Appl Opt 37 1998 5019 5030 [74] W.B. Sun Q. Fu Anomalous diffraction theory for arbitrarily oriented hexagonal crystals JQSRT 63 1999 727 737 [75] L.I. Schiff Approximation method for short wavelength or high-energy scattering Phys Rev 104 1956 1481 1485 [76] R.J. Glauber High-energy collision theory W.E. Britten L.C. Dunham Lectures in theoretical physics. 1959 Interscience New York [77] T.W. Chen High energy light scattering in the generalized eikonal approximation Appl Opt 28 1989 4096 4102 [78] J.M. Perrin P. Chiappeta Light scattering by large particles I A new theoretical description in the eikonal picture. Opt Acta 32 1985 907 921 [79] W.J. Wiscombe Improved Mie scattering algorithms Appl Opt 19 1980 1505 1509 [80] D.L. Mitchell S.K. Chai Y. Liu A.J. Heymsfield Y. Dong Modeling cirrus clouds. Part I: treatment of bimodal size spectra and case study analysis J Atmos Sci 53 1996 2952 2966 [81] G.M. McFarquhar A.J. Heymsfield Microphysical characteristics of three cirrus anvils sampled during the central equatorial pacific experiment J Atmos Sci 53 1996 2401 2423 [82] G.M. McFarquhar A.J. Heymsfield A. Macke J. laquinta S.M. Aulenbach Use of observed ice crystal sizes and shapes to calculate mean scattering properties and multi-spectral radiances: CEPEX 4 April 1993 case study. J Geophys Res 104 1999 31,763 31,779 [83] J.S. Foot Some observations of the optical properties of clouds. Part II: Cirrus Quart J Roy Meteor Soc 114 1988 145 164 [84] J.E. Hansen L.D. Travis Light scattering in planetary atmosphere Space Sci Rev 16 1974 527 610 [85] K.N. Liou P. Yang Y. Takano K. Sassen T. Charlock W. Arnott On the radiative properties of contrail cirrus Geophys Res Lett 25 1998 1161 1164",
        "keywords": [],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Bo-Cai Gao",
                "org": "Remote Sensing Division, Naval Research Laboratory, Washington, DC, USA"
            },
            {
                "name": "Bryan A. Baum",
                "org": "NASA Langley Research Center, Hampton, VA, USA"
            },
            {
                "name": "Yong X. Hu",
                "org": "NASA Langley Research Center, Hampton, VA, USA"
            },
            {
                "name": "Warren J. Wiscombe",
                "org": "Code 913, NASA Goddard Space Flight Center, Greenbelt, MD 20771, USA"
            },
            {
                "name": "Si-Chee Tsay",
                "org": "Code 913, NASA Goddard Space Flight Center, Greenbelt, MD 20771, USA"
            },
            {
                "name": "Dave M. Winker",
                "org": "NASA Langley Research Center, Hampton, VA, USA"
            },
            {
                "name": "Shaima L. Nasiri",
                "org": "Cooperative Institute for Meteorological Satellite Studies, University of Wisconsin, Madison, WI, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy and Radiative Transfer",
        "year": 2001
    },
    "hPR80vtY": {
        "id": "hPR80vtY",
        "title": "A Review of Ice Cloud Optical Property Models for Passive Satellite Remote Sensing",
        "abstract": "The current wealth of spaceborne passive and active measurements from ultraviolet to the infrared wavelengths provides an unprecedented opportunity to construct ice cloud bulk optical property models that lead to consistent ice cloud property retrievals across multiple sensors and platforms. To infer the microphysical and radiative properties of ice clouds from these satellite measurements, the general approach is to assume an ice cloud optical property model that implicitly assumes the habit (shape) and size distributions of the ice particles in these clouds. The assumption is that this ice optical property model will be adequate for global retrievals. In this review paper, we first summarize the key optical properties of individual particles and then the bulk radiative properties of their ensemble, followed by a review of the ice cloud models developed for application to satellite remote sensing. We illustrate that the random orientation condition assumed for ice particles is arguably justified for passive remote sensing applications based on radiometric measurements. The focus of the present discussion is on the ice models used by the Moderate Resolution Imaging Spectroradiometer (MODIS) and the Clouds and Earth\u2019s Radiant Energy System (CERES) science teams. In addition, we briefly review the ice cloud models adopted by the Polarization and Directionality of the Earth\u2019s Reflectance (POLDER) and the Himawari-8 Advanced Himawari Imager (AHI) for ice cloud retrievals. We find that both the MODIS Collection 6 ice model and the CERES two-habit model result in spectrally consistent retrievals.",
        "keywords": "",
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Souichiro Hioki",
                "org": ""
            },
            {
                "name": "Masanori Saito",
                "org": ""
            },
            {
                "name": "Chia-Pang Kuo",
                "org": ""
            },
            {
                "name": "Bryan A. Baum",
                "org": ""
            },
            {
                "name": "Kuo-Nan Liou",
                "org": ""
            }
        ],
        "venue": "Atmosphere",
        "year": 2018
    },
    "fEMoaFvg": {
        "id": "fEMoaFvg",
        "title": "Effects of ice crystal surface roughness and air bubble inclusions on cirrus cloud radiative properties from remote sensing perspective",
        "abstract": "Abstract   We study the combined effects of surface roughness and inhomogeneity on the optical scattering properties of ice crystals and explore the consequent implications to remote sensing of cirrus cloud properties. Specifically, surface roughness and inhomogeneity are added to the Moderate Resolution Imaging Spectroradiometer (MODIS) collection 6 (MC6) cirrus cloud particle habit model. Light scattering properties of the new habit model are simulated using a modified version of the Improved Geometric Optics Method (IGOM). Both inhomogeneity and surface roughness affect the single scattering properties significantly. In visible bands, inhomogeneity and surface roughness both tend to smooth the phase function and eliminate halos and the backscattering peak. The asymmetry parameter varies with the degree of surface roughness following a U shape - decreases and then increases - with a minimum at around 0.15, whereas it decreases monotonically with the air bubble volume fraction. Air bubble inclusions significantly increase phase matrix element - P  12  for scattering angles between 20\u00b0\u2013120\u00b0, whereas surface roughness has a much weaker effect, increasing - P  12  slightly from 60\u00b0\u2013120\u00b0. Radiative transfer simulations and cirrus cloud property retrievals are conducted by including both the factors. In terms of surface roughness and air bubble volume fraction, retrievals of cirrus cloud optical thickness or the asymmetry parameter using solar bands show similar patterns of variation. Polarimetric simulations using the MC6 cirrus cloud particle habit model are shown to be more consistent with observations when both surface roughness and inhomogeneity are simultaneously considered.",
        "keywords": "",
        "authors": [
            {
                "name": "Guanglin Tang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, USA"
            },
            {
                "name": "R. Lee Panetta",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, USA"
            },
            {
                "name": "George W. Kattawar",
                "org": "Department of Physics & Astronomy, Texas A&M University, College Station, TX, USA"
            },
            {
                "name": "Peng-Wang Zhai",
                "org": "Department of Physics, University of Maryland, Baltimore County, MD, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2017
    },
    "ILOWx2Bb": {
        "id": "ILOWx2Bb",
        "title": "Comparison of PARASOL Observations with Polarized Reflectances Simulated Using Different Ice Habit Mixtures",
        "abstract": "",
        "keywords": [
            "radiative transfer",
            "albedo",
            "reflectance",
            "atmospheric models"
        ],
        "authors": [
            {
                "name": "benjamin h cole",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "bryan a baum",
                "org": ""
            },
            {
                "name": "jerome riedi",
                "org": ""
            },
            {
                "name": "laurent c labonnote",
                "org": ""
            },
            {
                "name": "francois thieuleux",
                "org": ""
            },
            {
                "name": "steven platnick",
                "org": ""
            }
        ],
        "venue": "Journal of Applied Meteorology and Climatology",
        "year": 2013
    },
    "b0fXUakp": {
        "id": "b0fXUakp",
        "title": "FDTD far-field scattering amplitudes: Comparison of surface and volume integration methods",
        "abstract": "The transformation of the near-field to the corresponding far-field is a key step involved in the application of the finite-difference time-domain (FDTD) technique to the scattering of an electromagnetic wave by a dielectric particle. In practice, either a volume-integral method (VIM) or an equivalent surface-integral method (SIM) can be used to calculate the far-field. Previous studies reported in the literature demonstrated that a fine grid resolution is necessary for implementing the FDTD technique with the aforementioned VIM for electromagnetic scattering of plane waves by a dielectric particle with a large refractive index. A fine grid resolution leads to a significant amount of computational effort in terms of computer memory and CPU time, and consequently, substantially limits the applicability of the FDTD technique. In this study, we show that the SIM allows a much coarser grid resolution than that required by the VIM. The physical mechanism associated with the advantages of the SIM is also discussed. Furthermore, it is demonstrated that the same order of numerical errors for the phase function computation can be achieved using the SIM with a grid size of \u0394 s = \u03bb / 40 for the two published large refractive indices, namely m = 7.1499 + i 2.914 and 8.2252 + i 1.6808 , whereas the grid size required by the VIM, as reported in the literature, needs to be \u0394 s = \u03bb / 143 or \u03bb / 165 . With the SIM, the scattering properties of particles with complex refractive indices as large as 7.1499 + i 2.914 can be simulated by the FDTD technique for size parameters up to 20 by using an ordinary desktop computer.",
        "keywords": [
            "light scattering",
            "near- to far-field transformation",
            "phase matrix",
            "finite-difference time-domain method",
            "finite difference time domain",
            "scattering amplitude",
            "near field",
            "electromagnetic waves",
            "refractive index",
            "plane waves"
        ],
        "authors": [
            {
                "name": "Peng-Wang Zhai",
                "org": ""
            },
            {
                "name": "Changhui Li",
                "org": "Department of Physics, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "George W. Kattawar",
                "org": "Department of Physics, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy and Radiative Transfer",
        "year": 2007
    },
    "rVrzFJoF": {
        "id": "rVrzFJoF",
        "title": "Many-body iterative T- matrix method for large aspect ratio particles",
        "abstract": "",
        "keywords": [
            "t matrix method"
        ],
        "authors": [
            {
                "name": "bingqiang sun",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "george w kattawar",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2013
    },
    "DBHYJjaA": {
        "id": "DBHYJjaA",
        "title": "Comparison between the pseudo-spectral time domain method and the discrete dipole approximation for light scattering simulations",
        "abstract": "",
        "keywords": [
            "atmospheric optics",
            "scattering"
        ],
        "authors": [
            {
                "name": "chao liu",
                "org": "texas a m university"
            },
            {
                "name": "lei bi",
                "org": "texas a m university"
            },
            {
                "name": "r lee panetta",
                "org": "texas a m university"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "maxim a yurkin",
                "org": ""
            }
        ],
        "venue": "Optics Express",
        "year": 2012
    },
    "FO72GjJc": {
        "id": "FO72GjJc",
        "title": "Validation of quasi-invariant ice cloud radiative quantities with MODIS satellite-based cloud property retrievals",
        "abstract": "Abstract   Similarity relations applied to ice cloud radiance calculations are theoretically analyzed and numerically validated. If  \u03c4 (1\u2013 \u03d6 ) and  \u03c4 (1\u2013 \u03d6g ) are conserved where  \u03c4  is optical thickness,  \u03d6  the single-scattering albedo, and  g  the asymmetry factor, it is possible that substantially different phase functions may give rise to similar radiances in both conservative and non-conservative scattering cases, particularly in the case of large optical thicknesses. In addition to theoretical analysis, this study uses operational ice cloud optical thickness retrievals from the Moderate Resolution Imaging Spectroradiometer (MODIS) Level 2 Collection 5 (C5) and Collection 6 (C6) cloud property products to verify radiative similarity relations. It is found that, if the MODIS C5 and C6 ice cloud optical thickness values are multiplied by their respective (1\u2013 \u03d6g ) factors, the resultant products referred to as the effective optical thicknesses become similar with their ratio values around unity. Furthermore, the ratios of the C5 and C6 ice cloud effective optical thicknesses display an angular variation pattern similar to that of the corresponding ice cloud phase function ratios. The MODIS C5 and C6 values of ice cloud similarity parameter, defined as [(1\u2013 \u03d6 )/(1\u2013 \u03d6g )] 1/2 , also tend to be similar.",
        "keywords": "",
        "authors": [
            {
                "name": "Jiachen Ding",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77845, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77845, USA"
            },
            {
                "name": "George W. Kattawar",
                "org": "Department of Physics & Astronomy and Institute for Quantum Science and Engineering, Texas A&M University, College Station 77845, TX, USA"
            },
            {
                "name": "Michael D. King",
                "org": "Laboratory for Atmospheric & Space Physics, University of Colorado, CO 80303, USA"
            },
            {
                "name": "Michael D. King",
                "org": "Laboratory for Atmospheric & Space Physics, University of Colorado, CO 80303, USA"
            },
            {
                "name": "Steven Platnick",
                "org": "Earth Sciences Division, NASA Goddard Space Flight Center, Greenbelt, MD 20771, USA"
            },
            {
                "name": "Kerry Meyer",
                "org": "Earth Sciences Division, NASA Goddard Space Flight Center, Greenbelt, MD 20771, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2017
    },
    "aD6MnRpE": {
        "id": "aD6MnRpE",
        "title": "Ice particle morphology and microphysical properties of cirrus clouds inferred from combined CALIOP\u2013IIR measurements\u2020",
        "abstract": "Ice particle morphology and microphysical properties of cirrus clouds are essential for assessing radiative forcing associated with these clouds. We develop an optimal estimation-based algorithm to infer cirrus cloud optical thickness (COT), cloud effective radius (CER), plate fraction including quasi-horizontally oriented plates (HOPs) and the degree of surface roughness from the Cloud Aerosol Lidar with Orthogonal Polarization (CALIOP) and the Infrared Imaging Radiometer (IIR) on the CALIPSO platform. A simple but realistic ice particle model is used, and the relevant bulk optical properties are computed using state-of-the-art light-scattering computational capabilities. Rigorous estimation of uncertainties related to surface properties, atmospheric gases and cloud heterogeneity is performed. The results based on the present method show that COTs are quite consistent with other satellite products, and CERs essentially agree with the other counterparts. A one-month global analysis for April 2007, in which CALIPSO off-nadir angle is 0.3\u2218, shows that the HOP has significant temperature-dependence and is critical to the lidar ratio when cloud temperature is warmer than \u221240\u2218C. The lidar ratio is calculated from the bulk optical properties based on the inferred parameters, showing robust temperature dependence. The median lidar ratio of cirrus clouds is 27\u201331 sr over the globe.",
        "keywords": "",
        "authors": [
            {
                "name": "Masanori Saito",
                "org": "Department of Geophysics, Graduate School of Science Tohoku University Sendai Japan"
            },
            {
                "name": "Hironobu Iwabuchi",
                "org": "Department of Geophysics, Graduate School of Science Tohoku University Sendai Japan"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences Texas A&M University College Station Texas USA"
            },
            {
                "name": "Guanglin Tang",
                "org": "Department of Atmospheric Sciences Texas A&M University College Station Texas USA"
            },
            {
                "name": "Michael D. King",
                "org": "Department of Atmospheric Sciences Texas A&M University College Station Texas USA"
            },
            {
                "name": "Michael D. King",
                "org": "Department of Atmospheric Sciences Texas A&M University College Station Texas USA"
            },
            {
                "name": "Miho Sekiguchi",
                "org": "Department of Marine Electronics and Mechanical Engineering Tokyo University of Marine Science and Technology Tokyo Japan"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2017
    },
    "x2bmFDOE": {
        "id": "x2bmFDOE",
        "title": "Oriented Ice Crystals: A Single-scattering Property Database for Applications to Lidar and Optical Phenomenon Simulations",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Masanori Saito",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX"
            }
        ],
        "venue": "Journal of the Atmospheric Sciences",
        "year": 2019
    },
    "mc4t2zkF": {
        "id": "mc4t2zkF",
        "title": "Improvements on the ice cloud modeling capabilities of the Community Radiative Transfer Model: Improved Ice Optical Properties of CRTM",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Bingqi Yi",
                "org": "Department of Atmospheric Sciences; Texas A&M University; College Station Texas USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences; Texas A&M University; College Station Texas USA"
            },
            {
                "name": "Quanhua Liu",
                "org": "ESSIC; University of Maryland; College Park Maryland USA"
            },
            {
                "name": "Paul van Delst",
                "org": "Joint Center for Satellite Data Assimilation; College Park Maryland USA"
            },
            {
                "name": "Sid-Ahmed Boukabara",
                "org": "Joint Center for Satellite Data Assimilation; College Park Maryland USA"
            },
            {
                "name": "Fuzhong Weng",
                "org": "NOAA/NESDIS/STAR; College Park Maryland USA"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2016
    },
    "Z7WV5M8X": {
        "id": "Z7WV5M8X",
        "title": "Impact of Aviation on Climate: FAA\u2019s Aviation Climate Change Research Initiative (ACCRI) Phase II",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "guy p brasseur",
                "org": "max planck society"
            },
            {
                "name": "mohan gupta",
                "org": ""
            },
            {
                "name": "b e anderson",
                "org": ""
            },
            {
                "name": "sathya balasubramanian",
                "org": ""
            },
            {
                "name": "steven r h barrett",
                "org": ""
            },
            {
                "name": "david p duda",
                "org": ""
            },
            {
                "name": "gregg g fleming",
                "org": ""
            },
            {
                "name": "piers m forster",
                "org": ""
            },
            {
                "name": "jan s fuglestvedt",
                "org": ""
            },
            {
                "name": "andrew gettelman",
                "org": ""
            },
            {
                "name": "rangasayi n halthore",
                "org": ""
            },
            {
                "name": "s daniel jacob",
                "org": ""
            },
            {
                "name": "mark z jacobson",
                "org": ""
            },
            {
                "name": "arezoo khodayari",
                "org": ""
            },
            {
                "name": "kuonan liou",
                "org": ""
            },
            {
                "name": "m t lund",
                "org": ""
            },
            {
                "name": "richard c miakelye",
                "org": ""
            },
            {
                "name": "patrick minnis",
                "org": ""
            },
            {
                "name": "seth c olsen",
                "org": ""
            },
            {
                "name": "joyce e penner",
                "org": ""
            },
            {
                "name": "ronald g prinn",
                "org": ""
            },
            {
                "name": "ulrich schumann",
                "org": ""
            },
            {
                "name": "henry b selkirk",
                "org": ""
            },
            {
                "name": "andrei p sokolov",
                "org": ""
            },
            {
                "name": "nadine unger",
                "org": ""
            },
            {
                "name": "philip j wolfe",
                "org": ""
            },
            {
                "name": "hsiwu wong",
                "org": ""
            },
            {
                "name": "donald w wuebbles",
                "org": ""
            },
            {
                "name": "bingqi yi",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "cheng zhou",
                "org": ""
            }
        ],
        "venue": "Bulletin of the American Meteorological Society",
        "year": 2015
    },
    "mzQOIDxL": {
        "id": "mzQOIDxL",
        "title": "Comparative strengths of a pseudo-spectral time domain method in numerical simulation of single particle optical scattering",
        "abstract": "",
        "keywords": [
            "light scattering"
        ],
        "authors": [
            {
                "name": "r l panetta",
                "org": "texas a m university"
            },
            {
                "name": "chao liu",
                "org": "texas a m university"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            }
        ],
        "venue": "",
        "year": 2011
    },
    "Hb9KKjTA": {
        "id": "Hb9KKjTA",
        "title": "Impact of pollution on the optical properties of trans-Pacific East Asian dust from satellite and ground-based measurements: Impact of pollution on dust properties",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bryan a baum",
                "org": ""
            },
            {
                "name": "bingqi yi",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2014
    },
    "RO6tgYBT": {
        "id": "RO6tgYBT",
        "title": "Expansion of tabulated scattering matrices in generalized spherical functions",
        "abstract": "Abstract   An efficient way to solve the vector radiative transfer equation for plane-parallel turbid media is to Fourier-decompose it in azimuth. This methodology is typically based on the analytical computation of the Fourier components of the phase matrix and is predicated on the knowledge of the coefficients appearing in the expansion of the normalized scattering matrix in generalized spherical functions. Quite often the expansion coefficients have to be determined from tabulated values of the scattering matrix obtained from measurements or calculated by solving the Maxwell equations. In such cases one needs an efficient and accurate computer procedure converting a tabulated scattering matrix into the corresponding set of expansion coefficients. This short communication summarizes the theoretical basis of this procedure and serves as the user guide to a simple public-domain FORTRAN program.",
        "keywords": "",
        "authors": [
            {
                "name": "Michael I. Mishchenko",
                "org": "NASA Goddard Institute for Space Studies, 2880 Broadway, New York, NY 10025, USA"
            },
            {
                "name": "Igor V. Geogdzhayev",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2016
    },
    "PKQmGIGz": {
        "id": "PKQmGIGz",
        "title": "Discriminating between spherical and non-spherical scatterers with lidar using circular polarization: a theoretical study",
        "abstract": "For ground based observations, depolarization of lidar backscatter indicates that the scattering particles are non-spherical. This property provides a useful means to discriminate between ice particles (non-spherical) and water droplets (spherical) in clouds. However, for space based lidar measurements, backscatter from spherical water cloud particles is also depolarized due to multiple scattering. For the spaceborne lidar application, the discrimination between water and ice is not straightforward. An alternative method for water/ice discrimination that is less sensitive to multiple scattering is proposed in this study. The new approach is based on the differences in P 44 (an element of the scattering phase matrix) at 180\u00b0 scattering angle between spherical and non-spherical particles. By transmitting a circularly polarized beam from the lidar and resolving the rotational sense of the polarization in the receiver, discrimination between spherical and non-spherical scatterers can be accomplished even when multiple scattering occurs. When the incident beam is left-hand-circularly polarized, the circular component of backscatter by a non-spherical particle is weak and possibly left-handed, whereas backscatter by a spherical particle is significantly right-hand-circularly polarized. Monte Carlo simulations with full Stokes vector parameterizations indicate that multiple scattering does not affect the rotational sense of the backscatter polarization, making robust discrimination between spheres and non-spheres possible with this new circular polarization approach.",
        "keywords": [
            "monte carlo simulation",
            "circular polarization"
        ],
        "authors": [
            {
                "name": "Yong-X Hu",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Science, Texas A&M, College Station, TX 77843, USA"
            },
            {
                "name": "Bing Lin",
                "org": "MS 420, NASA LaRC, Hampton, VA 23681-2199, USA"
            },
            {
                "name": "Gary Gibson",
                "org": "MS 420, NASA LaRC, Hampton, VA 23681-2199, USA"
            },
            {
                "name": "Chris Hostetler",
                "org": "MS 420, NASA LaRC, Hampton, VA 23681-2199, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy and Radiative Transfer",
        "year": 2003
    },
    "BZ4W0hye": {
        "id": "BZ4W0hye",
        "title": "A Fast Vector Radiative Transfer Model for the Atmosphere-Ocean Coupled System",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jiachen Ding",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77845, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77845, USA"
            },
            {
                "name": "Michael D. King",
                "org": "Laboratory for Atmospheric & Space Physics, University of Colorado Boulder, Boulder, CO 80303, USA"
            },
            {
                "name": "Steven Platnick",
                "org": "Earth Sciences Division, NASA Goddard Space Flight Center, Greenbelt, MD 20771, USA"
            },
            {
                "name": "Xu Liu",
                "org": "NASA Langley Research Center, Hampton, VA 23681, USA"
            },
            {
                "name": "Kerry G. Meyer",
                "org": "Earth Sciences Division, NASA Goddard Space Flight Center, Greenbelt, MD 20771, USA"
            },
            {
                "name": "Chenxi Wang",
                "org": "University of Maryland, College Park, MD 20740, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2019
    },
    "ygYOQM23": {
        "id": "ygYOQM23",
        "title": "Impact of cirrus crystal shape on solar spectral irradiance: A case study for subtropical cirrus",
        "abstract": "Profiles of in situ measurements of ice crystal size distribution of subtropical cirrus were used to calculate solar spectral irradiances above and below the clouds. Spheres and nonspherical ice crystal habits (columns, hollows, plates, bullets, and aggregates) were assumed in the calculations. The simulation results were compared to irradiance measurements from the NASA Solar Spectral Flux Radiometer. The microphysical and radiation data were collected by three aircraft during CRYSTAL-FACE. Two cirrus cases (optical thickness of about 1 and 7) from two mission dates (26 and 23 July 2002) were investigated in detail. The measured downwelling and upwelling irradiance spectra above the cirrus could mostly be reproduced by the radiation model to within \u00b15\u201310% for most ice crystal habits. Below the cirrus the simulations disagreed with the measured irradiances due to surface albedo variability along the flight track, and nonoptimal colocation between the microphysical and irradiance measurements. The impact of shape characteristics of the crystals was important for the reflected irradiances above the optically thin cirrus, especially for small solar zenith angles, because in this case single-scattering dominated the solar radiation field. For the cirrus of moderate optical thickness the enhanced multiple scattering tended to diminish particular shape features caused by nonspherical single-scattering. Within the ice absorption bands the shape-related differences in the absorption characteristics of the individual nonspherical ice crystals were amplified if multiple scattering prevailed. Furthermore, it was found that below the cloud the shape sensitivity of the downwelling irradiance spectra is larger compared to the nonsphericity effects on reflected irradiances above the cirrus. Finally, it was shown that the calculated cirrus solar radiative forcing could vary by as much as 26% depending on the ice crystal habit.",
        "keywords": [
            "atmospheric solar radiation",
            "crystal shape influence",
            "cirrus clouds",
            "solar physics",
            "shapes",
            "radiative forcing",
            "temperate regions",
            "solar irradiance",
            "irradiance",
            "optical thickness",
            "crystals",
            "solar radiation",
            "solar flux",
            "simulation"
        ],
        "authors": [
            {
                "name": "manfred wendisch",
                "org": "ames research center"
            },
            {
                "name": "peter pilewskie",
                "org": "ames research center"
            },
            {
                "name": "j pommier",
                "org": ""
            },
            {
                "name": "steve howard",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "andrew j heymsfield",
                "org": "national center for atmospheric research"
            },
            {
                "name": "carl schmitt",
                "org": "national center for atmospheric research"
            },
            {
                "name": "d baumgardner",
                "org": "national autonomous university of mexico"
            },
            {
                "name": "b mayer",
                "org": ""
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2005
    },
    "WtHQyEpV": {
        "id": "WtHQyEpV",
        "title": "Determination of complex refractive index of polystyrene microspheres from 370 to 1610 nm.",
        "abstract": "We introduce an inverse method for determining simultaneously the real and imaginary refractive indices of microspheres based on integrating sphere measurements of diffuse reflectance and transmittance, and Monte Carlo modelling in conjunction with the Mie theory. The results for polystyrene microspheres suspended in water are presented.",
        "keywords": [
            "refractive index",
            "monte carlo",
            "diffuse reflectance",
            "mie theory"
        ],
        "authors": [
            {
                "name": "Xiaoyan Ma",
                "org": ""
            },
            {
                "name": "Jun Q Lu",
                "org": ""
            },
            {
                "name": "R Scott Brock",
                "org": ""
            },
            {
                "name": "Kenneth M Jacobs",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Xin-Hua Hu",
                "org": ""
            }
        ],
        "venue": "Physics in medicine and biology",
        "year": 2003
    },
    "ahD647xL": {
        "id": "ahD647xL",
        "title": "Electric and magnetic energy density distributions inside and outside dielectric particles illuminated by a plane electromagnetic wave",
        "abstract": "",
        "keywords": [
            "scattering",
            "fluorescence spectroscopy",
            "mie theory",
            "electromagnetic waves",
            "numerical simulation"
        ],
        "authors": [
            {
                "name": "Kattawar George",
                "org": "texas a m university"
            },
            {
                "name": "Li Changhui",
                "org": "texas a m university"
            },
            {
                "name": "Zhai Peng-Wang",
                "org": "texas a m university"
            },
            {
                "name": "Yang Ping",
                "org": "texas a m university"
            }
        ],
        "venue": "Optics Express",
        "year": 2005
    },
    "pTFD5oYU": {
        "id": "pTFD5oYU",
        "title": "Optical properties of nonspherical atmospheric particles and relevant applications",
        "abstract": "",
        "keywords": [
            "fdtd"
        ],
        "authors": [
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "lei bi",
                "org": ""
            },
            {
                "name": "george w kattawar",
                "org": ""
            },
            {
                "name": "r l panetta",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2011
    },
    "rqzdMhdP": {
        "id": "rqzdMhdP",
        "title": "Simulation of the global contrail radiative forcing: A sensitivity analysis: CONTRAIL RADIATIVE FORCING",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "joyce e penner",
                "org": ""
            },
            {
                "name": "patrick minnis",
                "org": ""
            },
            {
                "name": "kuonan liou",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "bingqi yi",
                "org": ""
            }
        ],
        "venue": "Geophysical Research Letters",
        "year": 2012
    },
    "XIkdRH7T": {
        "id": "XIkdRH7T",
        "title": "A comparison of Aqua MODIS ice and liquid water cloud physical and optical properties between collection 6 and collection 5.1: Cloud radiative effects",
        "abstract": "In our companion study, we show how cloud property products change from MODIS (Moderate Resolution Imaging Spectroradiometer) collection 5.1 (C51) to collection 6 (C6) for both ice and liquid water clouds through a pixel-to-pixel comparison. However, the question remains as to the full impacts of these cloud property differences between collections on the inference of cloud radiative effects (CREs). In this study, we address this question from a modeling perspective using one\u00a0year (2012) of MODIS gridded annual-averaged ice/liquid water cloud properties at 0.5\u00b0\u00a0\u00d7\u00a00.5\u00b0 spatial resolution. The rapid radiative transfer model for general circulation model applications is used to simulate the broadband radiative fluxes at the top of the atmosphere under clear-sky and cloudy-sky conditions. The shortwave, longwave, and net radiative effects of ice, liquid water, and total clouds are derived individually assuming different cloud optical property parameterization schemes. The results provide quantifications of ice and liquid water CRE contributions to the total CRE. We find significant differences in the simulated CREs between C6 and C51 for ice clouds (up to 23\u00a0W\u00a0m\u22122 for the shortwave CRE) and liquid water clouds (approximately \u22124.5\u00a0W\u00a0m\u22122 for the shortwave CRE). The C6 total CRE provides the closest match with the Clouds and the Earthu0027s Radiant Energy System Energy Balanced And Filled product. Sensitivity studies are performed to estimate the impacts of different ice optical parameterization schemes and multilayer cloud overlap assumptions. Results show that the C6\u2013C51 CRE differences are larger than the CRE variations caused by the other factors.",
        "keywords": "",
        "authors": [
            {
                "name": "Bingqi Yi",
                "org": "Department of Atmospheric Sciences Texas A&M University Texas USA"
            },
            {
                "name": "Anita D. Rapp",
                "org": "Department of Atmospheric Sciences Texas A&M University Texas USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences Texas A&M University Texas USA"
            },
            {
                "name": "Bryan A. Baum",
                "org": "Space Science and Engineering Center University of Wisconsin\u2010Madison Madison Wisconsin USA"
            },
            {
                "name": "Michael D. King",
                "org": "Department of Atmospheric Sciences Texas A&M University Texas USA"
            },
            {
                "name": "Michael D. King",
                "org": "Department of Atmospheric Sciences Texas A&M University Texas USA"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2017
    },
    "tkJYUYrT": {
        "id": "tkJYUYrT",
        "title": "Mueller matrix imaging of targets under an air-sea interface.",
        "abstract": "The Mueller matrix imaging method is a powerful tool for target detection. In this study, the effect of the air-sea interface on the detection of underwater objects is studied. A backward Monte Carlo code has been developed to study this effect. The main result is that the reflection of the diffuse sky light by the interface reduces the Mueller image contrast. If the air-sea interface is ruffled by wind, the distinction between different regions of the underwater target is smoothed out. The effect of the finite size of an active light source is also studied. The image contrast is found to be relatively insensitive to the size of the light source. The volume scattering function plays an important role on the underwater object detection. Generally, a smaller asymmetry parameter decreases the contrast of the polarimetry images.",
        "keywords": [
            "backscattering",
            "polarimetry",
            "mueller matrix",
            "radiative transfer"
        ],
        "authors": [
            {
                "name": "Peng-Wang Zhai",
                "org": ""
            },
            {
                "name": "George W Kattawar",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences|Texas A&M University"
            }
        ],
        "venue": "Applied optics",
        "year": 2009
    },
    "29Q9jXwq": {
        "id": "29Q9jXwq",
        "title": "Retrieval of Cirrus Cloud Optical Depth under Day and Night Conditions from MODIS Collection 6 Cloud Property Data",
        "abstract": "",
        "keywords": [
            "particle size",
            "optical depth"
        ],
        "authors": [
            {
                "name": "andrew k heidinger",
                "org": ""
            },
            {
                "name": "yue li",
                "org": ""
            },
            {
                "name": "bryan a baum",
                "org": ""
            },
            {
                "name": "robert e holz",
                "org": ""
            },
            {
                "name": "steven platnick",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            }
        ],
        "venue": "Remote Sensing",
        "year": 2015
    },
    "74QE75Ip": {
        "id": "74QE75Ip",
        "title": "Improvements in the computational efficiency and convergence of the Invariant Imbedding T-matrix method for spheroids and hexagonal prisms.",
        "abstract": "The invariant-imbedding T-matrix (II-TM) method is a numerical method for accurately computing the single-scattering properties of dielectric particles. Because of the linearity of Maxwell's equations, the incident electric field and the scattered electric field can be related through a transition matrix (T-Matrix). The II-TM method computes the T-matrix through a matrix recurrence formula which stems from an electromagnetic volume integral equation. The recurrence starts with an inscribed sphere within the particle and ends with the circumscribed sphere of the particle. For each iteration, a matrix known as the U-matrix is computed with the Gauss Legendre (GL) quadrature, and matrix inversion is subsequently performed to obtain the T-matrix corresponding to the portion of the particle enclosed by the spherical shell. We modify a commonly used scheme to avoid applying the quadrature scheme to discontinuities. Moreover, we apply a new scheme to generate nodes and weights in conjunction with the GL quadrature. This leads to a considerable improvement on convergence and computational efficiency in the cases of hexagonal prisms and spheroids. The basic shapes of ice crystals in the atmosphere are hexagonal columns and plates. The single-scattering properties of hexagonal ice prisms are important to atmospheric optics, radiative transfer, and remote sensing. We demonstrate that the present approach can significantly accelerate the convergence in simulating light scattering by hexagonal ice crystals.",
        "keywords": "",
        "authors": [
            {
                "name": "Siyao Zhai",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station , TX, USA"
            },
            {
                "name": "R Lee Panetta",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station , TX, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station , TX, USA"
            }
        ],
        "venue": "Optics express",
        "year": 2019
    },
    "GTV0fF57": {
        "id": "GTV0fF57",
        "title": "Optical scattering simulation of ice particles with surface roughness modeled using the Edwards-Wilkinson equation",
        "abstract": "Abstract   Constructing an appropriate particle morphology model is essential for realistic simulation of optical properties of atmospheric particles. This paper presents a model for generating surface roughness based on a combination of methods from discrete differential geometry combined with a stochastic partial differential equation for surface evolution introduced by Edwards and Wilkinson. Scattering of light by roughened particles is simulated using the Invariant Imbedding T-Matrix (II-TM) method. The effects of surface roughness on the single-scattering properties, namely, the phase matrix, asymmetry factor, and extinction efficiency, are investigated for a single wavelength in the visible range and for a range of size parameters up to  x =50. Three different smooth shapes are considered: spherical, spheroidal, and hexagonal, the latter two in just the \u201ccompact particle\u201d case of unit aspect ratio. It is shown that roughness has negligible effects on the optical scattering properties for size parameters less than 20. For size parameters ranging from 20 to 50, the phase matrix elements are more sensitive to the surface roughness than are two important integral optical properties, the extinction efficiency and asymmetry factor. As has been seen in studies using other forms of roughening, the phase function is progressively smoothed as roughness increases. The effect on extinction efficiency is to increase it, and on asymmetry factor is to decrease it. Each of these effects is relatively modest in the size range considered, but the trend of results suggests that greater effects will be seen for size parameters larger than ones considered here.",
        "keywords": "",
        "authors": [
            {
                "name": "Jianing Zhang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, United States"
            },
            {
                "name": "Lei Bi",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, United States"
            },
            {
                "name": "Jianping Liu",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, United States"
            },
            {
                "name": "R. Lee Panetta",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, United States"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, United States"
            },
            {
                "name": "George W. Kattawar",
                "org": "Department of Physics and Astronomy, Texas A&M University, College Station, TX, United States"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2016
    },
    "lO2KAT8f": {
        "id": "lO2KAT8f",
        "title": "A fast Visible Infrared Imaging Radiometer Suite simulator for cloudy atmospheres",
        "abstract": "",
        "keywords": [
            "data acquisition",
            "infrared radiation",
            "optical thickness",
            "scattering",
            "cloud cover",
            "radiative transfer",
            "absorptivity",
            "environmental monitoring",
            "brightness temperature"
        ],
        "authors": [
            {
                "name": "chao liu",
                "org": "texas a m university"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "s l nasiri",
                "org": "texas a m university"
            },
            {
                "name": "steven platnick",
                "org": "goddard space flight center"
            },
            {
                "name": "kerry meyer",
                "org": "goddard space flight center"
            },
            {
                "name": "chen xi wang",
                "org": "university of maryland college park"
            },
            {
                "name": "shouguo ding",
                "org": "university of nebraska lincoln"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2015
    },
    "O90WXlYU": {
        "id": "O90WXlYU",
        "title": "Single-scattering properties of Platonic solids in geometrical-optics regime",
        "abstract": "",
        "keywords": [
            "cross section",
            "surface area",
            "geometric optics",
            "platonic solids"
        ],
        "authors": [
            {
                "name": "Zhibo Zhang",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "George W. Kattawar",
                "org": "Department of Physics, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Warren J. Wiscombe",
                "org": "NASA Goddard Space Flight Center, Greenbelt, MD 20771, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy and Radiative Transfer",
        "year": 2007
    },
    "hKqVwOLO": {
        "id": "hKqVwOLO",
        "title": "Do contrails significantly reduce daily temperature range?",
        "abstract": "One of the most visible anthropogenic phenomena in the atmosphere is the occurrence of contrails. The direct effects of contrails on surface temperature are investigated on the basis of the data sets for the cloud cover and surface temperature over the conterminous United States for the period 1971\u20132001. It is shown that the increase of the average daily temperature range (DTR) over the United States during the three-day grounding period of 11\u201314 September 2001 cannot be attributed to the absence of contrails, a subject was debated in several previous studies. The present analysis suggests that the DTR is attributed to the change of low cloudiness.",
        "keywords": [
            "daily temperature range",
            "cloud",
            "contrail",
            "climate change",
            "surface temperature"
        ],
        "authors": [
            {
                "name": "Gang Hong",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Patrick Minnis",
                "org": ""
            },
            {
                "name": "Yong X. Hu",
                "org": ""
            },
            {
                "name": "Gerald North",
                "org": ""
            }
        ],
        "venue": "Geophysical Research Letters",
        "year": 2008
    },
    "XYVfQVgI": {
        "id": "XYVfQVgI",
        "title": "A fast infrared radiative transfer model based on the adding\u2013doubling method for hyperspectral remote-sensing applications",
        "abstract": "Abstract A fast infrared radiative transfer (RT) model is developed on the basis of the adding\u2010doubling principle, hereafter referred to as FIRTM-AD, to facilitate the forward RT simulations involved in hyperspectral remote-sensing applications under,cloudy-sky conditions. A pre-computed,look-up table (LUT) of the bidirectional reflection and,transmission functions and,emissivities of ice clouds in conjunction,with efficient interpolation schemes,is used in FIRTM-AD to alleviate the computational burden of the doubling process. FIRTM-AD is applicable to a variety of cloud conditions, including vertically inhomogeneous or multilayered clouds. In particular, this RT model is suitable for the computation of high-spectral-resolution radiance and brightness temperature (BT) spectra at both the top-of-atmosphere and surface, and thus is useful for satellite and ground-based hyperspectral sensors. In terms of computer CPU time, FIRTM-AD is approximately,100\u2010250 times faster than the well-known,discrete-ordinate (DISORT) RT model,for the same,conditions. The errors of FIRTM-AD, specified as root-mean-square (RMS) BT differences with respect to their DISORT counterparts, are generally smaller than 0.1K. r,2007 Elsevier Ltd. All rights reserved. Keywords: Hyperspectral; Radiative transfer; Clouds; Adding\u2010doubling; Remote sensing; Fast model",
        "keywords": [
            "adding-doubling",
            "clouds",
            "fast model",
            "hyperspectral",
            "radiative transfer",
            "remote sensing",
            "spectral resolution",
            "look up table",
            "root mean square",
            "radiative transfer model",
            "brightness temperature",
            "infrared"
        ],
        "authors": [
            {
                "name": "Zhibo Zhang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "George Kattawar",
                "org": "Department of Physics, Texas A&M University, College Station, TX, 77843, USA"
            },
            {
                "name": "Hung-Lung (Allen) Huang",
                "org": "CIMSS/University of Wisconsin-Madison, WI, USA"
            },
            {
                "name": "Thomas Greenwald",
                "org": "CIMSS/University of Wisconsin-Madison, WI, USA"
            },
            {
                "name": "Jun Li",
                "org": "CIMSS/University of Wisconsin-Madison, WI, USA"
            },
            {
                "name": "Bryan A. Baum",
                "org": "Space Science and Engineering Center, University of Wisconsin-Madison, WI, USA"
            },
            {
                "name": "Daniel K. Zhou",
                "org": "NASA Langley Research Center, USA"
            },
            {
                "name": "Yongxiang Hu",
                "org": "NASA Langley Research Center, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy and Radiative Transfer",
        "year": 2007
    },
    "AgnLaf4k": {
        "id": "AgnLaf4k",
        "title": "Bulk Scattering Properties for the Remote Sensing of Ice Clouds. 2: Narrowband Models",
        "abstract": "Abstract This study examines the development of bulk single-scattering properties of ice clouds, including single scattering albedo, asymmetry factor, and phase function, for a set of 1117 particle size distributions obtained from analysis of FIRE-I, FIRE-II, ARM-IOP, TRMM-KWAJEX, and CRYSTAL-FACE data. The primary focus is to develop band- averaged models appropriate for use by the MODIS imager on the EOS Terra and Aqua platforms, specifically for bands located at wavelengths of 0.65, 1.6, 2.1, and 3.75 \u221dm. Our results indicate that there are substantial differences in the bulk scattering properties of ice clouds formed in areas of deep convection and those that exist in areas of much lower updraft velocities. Band-averaged bulk scattering property results obtained from a particle-size depend- ent mixture of ice crystal habits are compared to those obtained assuming only solid hex-",
        "keywords": [],
        "authors": [
            {
                "name": "Bryan A. Baum",
                "org": "NASA Langley Research Center"
            },
            {
                "name": "Ping Yang",
                "org": "Texas A&M University"
            },
            {
                "name": "Andrew J. Heymsfield",
                "org": "National Center for Atmospheric Research"
            },
            {
                "name": "Steven Platnick",
                "org": "NASA Goddard Space Flight Center"
            },
            {
                "name": "Michael D. King",
                "org": "NASA Goddard Space Flight Center"
            },
            {
                "name": "Y.-X. Hu",
                "org": "NASA Langley Research Center"
            },
            {
                "name": "Sarah M. Thomas",
                "org": "Cooperative Institute for Meteorological Satellite Studies"
            }
        ],
        "venue": "",
        "year": 2005
    },
    "AnJ5FfV3": {
        "id": "AnJ5FfV3",
        "title": "Evaluation of a parallel FDTD code and application to modeling of light scattering by deformed red blood cells.",
        "abstract": "A parallel Finite-Difference-Time-Domain (FDTD) code has been developed to numerically model the elastic light scattering by biological cells. Extensive validation and evaluation on various computing clusters demonstrated the high performance of the parallel code and its significant potential of reducing the computational cost of the FDTD method with low cost computer clusters. The parallel FDTD code has been used to study the problem of light scattering by a human red blood cell (RBC) of a deformed shape in terms of the angular distributions of the Mueller matrix elements. The dependence of the Mueller matrix elements on the shape and orientation of the deformed RBC has been investigated. Analysis of these data provides valuable insight on determination of the RBC shapes using the method of elastic light scattering measurements.",
        "keywords": [
            "physiology",
            "mueller matrix",
            "finite difference time domain",
            "light scattering"
        ],
        "authors": [
            {
                "name": "R. Scott Brock",
                "org": ""
            },
            {
                "name": "Xin-Hua Hu",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Jun Q. Lu",
                "org": ""
            }
        ],
        "venue": "Optics express",
        "year": 2005
    },
    "U8bUqhfz": {
        "id": "U8bUqhfz",
        "title": "A novel parameterization of snow albedo based on a two-layer snow model with a mixture of grain habits",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Masanori Saito",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX"
            },
            {
                "name": "Norman G. Loeb",
                "org": "NASA Langley Research Center, Hampton, VA"
            },
            {
                "name": "Seiji Kato",
                "org": "NASA Langley Research Center, Hampton, VA"
            }
        ],
        "venue": "Journal of the Atmospheric Sciences",
        "year": 2019
    },
    "UZ7ChZpZ": {
        "id": "UZ7ChZpZ",
        "title": "On the Aerosol and Cloud Phase Function Expansion Moments for Radiative Transfer Simulations",
        "abstract": "",
        "keywords": [
            "radiative transfer"
        ],
        "authors": [
            {
                "name": "jiangnan li",
                "org": ""
            },
            {
                "name": "howard w barker",
                "org": "environment canada"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "bingqi yi",
                "org": "texas a m university"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2015
    },
    "mgcuUyIw": {
        "id": "mgcuUyIw",
        "title": "Radiance and polarization in the diffusion region with an arbitrary scattering phase matrix",
        "abstract": "Abstract   Radiance and polarization patterns in an optically deep region, the so-called diffusion region or asymptotic region, of a homogeneous atmosphere or ocean, depend mainly on the scattering phase matrix and the single-scattering albedo of the medium. The radiance and polarization properties in the diffusion region for an arbitrary scattering phase matrix can be obtained in terms of a series of the generalized spherical functions. The number of terms is closely related to the single-scattering albedo of the medium. If the medium is conservative, the radiance is isotropic in conjunction with no polarization. If the single-scattering albedo is close to 1, several terms are sufficient to obtain the patterns, in which the degree of polarization feature is less than 1%. If the medium is highly absorptive, more expansion terms are required to obtain the diffusion patterns. The examples of simulated radiance and polarization patterns for Rayleigh scattering, Henyey\u2013Greenstein\u2013Rayleigh scattering, and haze L and cloud C1 scattering, defined by Deirmendjian, are calculated.",
        "keywords": "",
        "authors": [
            {
                "name": "Bingqiang Sun",
                "org": "Department of Physics & Astronomy, Texas A&M University, College Station, TX 77843, United States"
            },
            {
                "name": "George W. Kattawar",
                "org": "Department of Physics & Astronomy, Texas A&M University, College Station, TX 77843, United States"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Physics & Astronomy, Texas A&M University, College Station, TX 77843, United States"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2016
    },
    "h0B4sevl": {
        "id": "h0B4sevl",
        "title": "Hyperspectral radiance simulator: cloudy radiance modeling and beyond",
        "abstract": "",
        "keywords": [
            "remote sensing",
            "spectral resolution",
            "water",
            "absorption",
            "modeling",
            "liquid water content",
            "test bed",
            "physical oceanography",
            "three dimensions",
            "particle size",
            "infrared",
            "particles",
            "radiative transfer model"
        ],
        "authors": [
            {
                "name": "hunglung huang",
                "org": "university of wisconsin madison"
            },
            {
                "name": "david c tobin",
                "org": "university of wisconsin madison"
            },
            {
                "name": "jun li",
                "org": "university of wisconsin madison"
            },
            {
                "name": "erik r olson",
                "org": "university of wisconsin madison"
            },
            {
                "name": "kevin baggett",
                "org": "university of wisconsin madison"
            },
            {
                "name": "bormin huang",
                "org": "university of wisconsin madison"
            },
            {
                "name": "john r mecikalski",
                "org": "university of wisconsin madison"
            },
            {
                "name": "robert o knuteson",
                "org": "university of wisconsin madison"
            },
            {
                "name": "brian j osborne",
                "org": "university of wisconsin madison"
            },
            {
                "name": "derek j posselt",
                "org": "university of wisconsin madison"
            },
            {
                "name": "p antonelli",
                "org": "university of wisconsin madison"
            },
            {
                "name": "henry e revercomb",
                "org": "university of wisconsin madison"
            },
            {
                "name": "william l smith",
                "org": "langley research center"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            }
        ],
        "venue": "",
        "year": 2003
    },
    "6thlTvG4": {
        "id": "6thlTvG4",
        "title": "Assessment of the Accuracy of the Conventional Ray-Tracing Technique: Implications in Remote Sensing and Radiative Transfer Involving Ice Clouds.",
        "abstract": "",
        "keywords": [
            "crystals",
            "geometrical optics",
            "simulation",
            "light scattering",
            "optical thickness",
            "radiative transfer",
            "remote sensing"
        ],
        "authors": [
            {
                "name": "lei bi",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "chao liu",
                "org": ""
            },
            {
                "name": "bingqi yi",
                "org": ""
            },
            {
                "name": "bryan a baum",
                "org": ""
            },
            {
                "name": "bastiaan van diedenhoven",
                "org": ""
            },
            {
                "name": "hironobu iwabuchi",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2014
    },
    "ox8moEhJ": {
        "id": "ox8moEhJ",
        "title": "ACCRI - A Report on the Way Forward based on the Review of Research Gaps and Priorities",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "guy p brasseur",
                "org": ""
            },
            {
                "name": "ulrike burkhardt",
                "org": ""
            },
            {
                "name": "a e dessler",
                "org": ""
            },
            {
                "name": "piers m de f forster",
                "org": ""
            },
            {
                "name": "andrew j heymsfield",
                "org": ""
            },
            {
                "name": "k n liou",
                "org": ""
            },
            {
                "name": "j c mcconnell",
                "org": ""
            },
            {
                "name": "steve ou",
                "org": ""
            },
            {
                "name": "helen rogers",
                "org": ""
            },
            {
                "name": "d w toohey",
                "org": ""
            },
            {
                "name": "donald w wuebbles",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2008
    },
    "eGdv1RXa": {
        "id": "eGdv1RXa",
        "title": "Retrieval of Ice Cloud Properties from AIRS and MODIS Observations Based on a Fast High-Spectral-Resolution Radiative Transfer Model",
        "abstract": "",
        "keywords": [
            "remote sensing",
            "radiative transfer"
        ],
        "authors": [
            {
                "name": "chenxi wang",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "steven platnick",
                "org": ""
            },
            {
                "name": "andrew k heidinger",
                "org": ""
            },
            {
                "name": "bryan a baum",
                "org": ""
            },
            {
                "name": "thomas j greenwald",
                "org": ""
            },
            {
                "name": "zhibo zhang",
                "org": ""
            },
            {
                "name": "robert e holz",
                "org": ""
            }
        ],
        "venue": "Journal of Applied Meteorology and Climatology",
        "year": 2013
    },
    "RBedIhC1": {
        "id": "RBedIhC1",
        "title": "Rigorous 3-D vectorial complex ray model applied to light scattering by an arbitrary spheroid",
        "abstract": "Abstract   After a ray bundle passes a curved surface, the equal-phase wavefront associated with the refracted rays will be distorted. Consequently, the cross-section of a ray bundle with a curved wavefront during propagation in a homogeneous medium will vary with the ray-bundle propagation distance. Moreover, the phase of a ray bundle with convergent wavefront will undergo a phase shift of  \u03c0 /2 with each passage of a focal line. The contribution to the scattering amplitude by a ray bundle after passing a scatterer is determined by three elements: the cross-section variation of its wavefront, the total phase, and the refraction coefficients determined by Fresnel equations. In the geometric optics regime, the aforesaid three elements caused by a curved surface can be systematically quantified in terms of the vectorial complex ray-tracing technique. In this study, rigorous vectorial complex ray-tracing calculations are conducted for light scattering by a general spheroid and the results are validated in comparison with the benchmarks provided by the rigorous T-matrix method.",
        "keywords": "",
        "authors": [
            {
                "name": "Bingqiang Sun",
                "org": "Department of Physics & Astronomy, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "George W. Kattawar",
                "org": "Department of Physics & Astronomy and Institute for Quantum Science and Engineering, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Kuan Fang Ren",
                "org": "CORIA-UMR6614, Normandie Universit\u00e9, CNRS, Universit\u00e9 et INSA de Rouen Av de l\u2019Universit\u00e9, 76800 Saint Etienne du Rouvray, France"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2016
    },
    "UN6PIBEP": {
        "id": "UN6PIBEP",
        "title": "Impact of Grain Shape and Multiple Black Carbon Internal Mixing on Snow Albedo: Parameterization and Radiative Effect Analysis",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Cenlin He",
                "org": "Joint Institute for Regional Earth System Science and Engineering, and Department of Atmospheric and Oceanic Sciences University of California Los Angeles CA USA"
            },
            {
                "name": "Cenlin He",
                "org": "Joint Institute for Regional Earth System Science and Engineering, and Department of Atmospheric and Oceanic Sciences University of California Los Angeles CA USA"
            },
            {
                "name": "Kuo-Nan Liou",
                "org": "Joint Institute for Regional Earth System Science and Engineering, and Department of Atmospheric and Oceanic Sciences University of California Los Angeles CA USA"
            },
            {
                "name": "Y. Takano",
                "org": "Joint Institute for Regional Earth System Science and Engineering, and Department of Atmospheric and Oceanic Sciences University of California Los Angeles CA USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences Texas A&M University College Station TX USA"
            },
            {
                "name": "Ling Qi",
                "org": ""
            },
            {
                "name": "Fei Chen",
                "org": "National Center for Atmospheric Research Boulder CO USA"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2018
    },
    "2Bf8Gyg7": {
        "id": "2Bf8Gyg7",
        "title": "Ice cloud single-scattering property models with the full phase matrix at wavelengths from 0.2 to 100 \u00b5m",
        "abstract": "",
        "keywords": [
            "light scattering",
            "radiative transfer",
            "remote sensing"
        ],
        "authors": [
            {
                "name": "bryan a baum",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "andrew j heymsfield",
                "org": ""
            },
            {
                "name": "aaron bansemer",
                "org": ""
            },
            {
                "name": "benjamin h cole",
                "org": ""
            },
            {
                "name": "aronne merrelli",
                "org": ""
            },
            {
                "name": "carl schmitt",
                "org": ""
            },
            {
                "name": "chenxi wang",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2014
    },
    "KS8IOwLU": {
        "id": "KS8IOwLU",
        "title": "Laboratory measurements of light scattering properties of kaolinite dust at 532 nm",
        "abstract": "ABSTRACTLight scattering by kaolinite dust samples at 532\u00a0nm is studied using a newly developed laboratory apparatus. During the experiments, dust samples are suspended in water, aerosolized by a nebulizer, and then injected into the scattering zone, with or without going through a diffusion drier, to generate either dried dust particles or water droplets with dust inclusions. The light source is a dual wavelength (532 and 1064\u00a0nm) diode-pumped solid state laser. Light scattered by an ensemble of particles is collected by a charge-coupled device (CCD) camera, which is mounted on the rotating arm of a stepper motor. The stepper motor rotates the CCD to cover the scattering angle range from 3\u00b0 to 177\u00b0. Polarized scattering light is measured for the horizontally and vertically polarized incident light. The apparatus is calibrated, using pure water droplets as the scattering media. The response function with respect to the scattering angle is obtained by comparing the measurements with Lorenz\u2013Mie calculations...",
        "keywords": "",
        "authors": [
            {
                "name": "Ron Li",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, Texas, USA"
            },
            {
                "name": "Guanglin Tang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, Texas, USA"
            },
            {
                "name": "Jiachen Ding",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, Texas, USA"
            },
            {
                "name": "Timothy Logan",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, Texas, USA"
            },
            {
                "name": "Sarah D. Brooks",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, Texas, USA"
            },
            {
                "name": "Don R. Collins",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, Texas, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, Texas, USA"
            },
            {
                "name": "George W. Kattawar",
                "org": "Department of Physics & Astronomy and Institute for Quantum Science and Engineering, Texas A&M University, College Station, Texas, USA"
            }
        ],
        "venue": "Aerosol Science and Technology",
        "year": 2018
    },
    "c0MyuBZ3": {
        "id": "c0MyuBZ3",
        "title": "Sensitivity of the backscattering Mueller matrix to particle shape and thermodynamic phase.",
        "abstract": "The Mueller matrix (M) corresponding to the phase matrix in the backscattering region (scattering angles ranging from 175 degrees to 180 degrees) is investigated for light scattering at a 0.532-microm wavelength by hexagonal ice crystals, ice spheres, and water droplets. For hexagonal ice crystals we assume three aspect ratios (plates, compact columns, and columns). It is shown that the contour patterns of the backscattering Mueller matrix elements other than M11, M44, M14, and M41 depend on particle geometry; M22 and M33 are particularly sensitive to the aspect ratio of ice crystals. The Mueller matrix for spherical ice particles is different from those for nonspherical ice particles. In addition to discriminating between spherical and nonspherical particles, the Mueller matrix may offer some insight as to cloud thermodynamic phase. The contour patterns for large ice spheres with an effective size of 100 microm are substantially different from those associated with small water droplets with an effective size of 4 microm.",
        "keywords": [
            "aspect ratio",
            "thermodynamics",
            "effect size",
            "mueller matrix",
            "light scattering",
            "atmospheric scattering",
            "backscattering"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Heli Wei",
                "org": ""
            },
            {
                "name": "George W Kattawar",
                "org": ""
            },
            {
                "name": "Yong X Hu",
                "org": ""
            },
            {
                "name": "David M Winker",
                "org": ""
            },
            {
                "name": "Chris A Hostetler",
                "org": ""
            },
            {
                "name": "Bryan A Baum",
                "org": ""
            }
        ],
        "venue": "Applied optics",
        "year": 2003
    },
    "MLKQeHD8": {
        "id": "MLKQeHD8",
        "title": "Detecting opaque and nonopaque tropical upper tropospheric ice clouds: A trispectral technique based on the MODIS 8\u201312 \u03bcm window bands",
        "abstract": "A trispectral technique is developed for detecting tropical upper tropospheric opaque (\u03c4 > 6) and nonopaque (\u03c4 < 6) ice clouds over ocean based on the brightness temperature differences between the MODIS 8.5 and 11 \u03bcm bands and between the 11 and 12 \u03bcm bands together with the MODIS detected cloud thermodynamic phase. The brightness temperature differences provide robust information for classifying ice clouds, as illustrated by the observations made by a lidar, a radar, and the MODIS Airborne Simulator over tropical ice anvil systems during the Cirrus Regional Study of Tropical Anvils and Cirrus Layers-Florida Area Cirrus Experiment. The trispectral technique for detecting tropical upper tropospheric opaque and nonopaque ice clouds is developed based on the analysis of 1 year of data, including MODIS infrared brightness temperatures at 8.5, 11, and 12 \u03bcm bands, MODIS-derived ice cloud optical thicknesses, and cloud top heights from CALIPSO and CloudSat over a region (140\u00b0E\u2013180\u00b0E, 0\u00b0N\u201320\u00b0N) in the Western Pacific Warm Pool. The accuracy of the present trispectral technique is above 80%. A 27 July 2007 MODIS granule over the chosen region is used to verify the trispectral technique. It is found that the classification from the trispectral technique is consistent with a classification based directly on the MODIS ice cloud optical thicknesses. The effects of the variations in the MODIS viewing zenith angle on the detection are found to be negligible. The CALIPSO and CloudSat observations used to develop the classification are more sensitive than MODIS to the height and presence of optically thin cirrus. These differences in cloud heights were found to have a negligible impact on the final detection results.",
        "keywords": [
            "opaque and nonopaque ice clouds",
            "modis",
            "brightness temperature",
            "thermodynamics",
            "infrared",
            "remote sensing"
        ],
        "authors": [
            {
                "name": "Gang Hong",
                "org": "Department of Atmospheric Sciences, Texas A&amp;M University, College Station, Texas, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&amp;M University, College Station, Texas, USA"
            },
            {
                "name": "Andrew K. Heidinger",
                "org": "NOAA/NESDIS Center for Satellite Applications and Research, Madison, Wisconsin, USA"
            },
            {
                "name": "Michael J. Pavolonis",
                "org": "NOAA/NESDIS Center for Satellite Applications and Research, Madison, Wisconsin, USA"
            },
            {
                "name": "Bryan A. Baum",
                "org": "Space Science and Engineering Center, University of Wisconsin Madison, Madison, Wisconsin, USA"
            },
            {
                "name": "Steven E. Platnick",
                "org": "Laboratory for Atmospheres, NASA-GSFC, Greenbelt, Maryland, USA"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2010
    },
    "z9w8nu3P": {
        "id": "z9w8nu3P",
        "title": "Scattering and absorption property database for nonspherical ice particles in the near- through far-infrared spectral region.",
        "abstract": "The single-scattering properties of ice particles in the near- through far-infrared spectral region are computed from a composite method that is based on a combination of the finite-difference time-domain technique, the T-matrix method, an improved geometrical-optics method, and Lorenz-Mie theory. Seven nonspherical ice crystal habits (aggregates, hexagonal solid and hollow columns, hexagonal plates, bullet rosettes, spheroids, and droxtals) are considered. A database of the single-scattering properties for each of these ice particles has been developed at 49 wavelengths between 3 and 100 microm and for particle sizes ranging from 2 to 10,000 microm specified in terms of the particle maximum dimension. The spectral variations of the single-scattering properties are discussed, as well as their dependence on the particle maximum dimension and effective particle size. The comparisons show that the assumption of spherical ice particles in the near-IR through far-IR region is generally not optimal for radiative transfer computation. Furthermore, a parameterization of the bulk optical properties is developed for mid-latitude cirrus clouds based on a set of 21 particle size distributions obtained from various field campaigns.",
        "keywords": [
            "finite difference time domain",
            "atmospheric optics",
            "geometric optics",
            "spectra",
            "atmospheric scattering",
            "infrared",
            "particle size distribution",
            "radiative transfer",
            "far infrared",
            "mie theory",
            "particle size"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Heli Wei",
                "org": ""
            },
            {
                "name": "Hung-Lung Huang",
                "org": ""
            },
            {
                "name": "Bryan A Baum",
                "org": ""
            },
            {
                "name": "Yong X Hu",
                "org": ""
            },
            {
                "name": "George W Kattawar",
                "org": ""
            },
            {
                "name": "Michael I Mishchenko",
                "org": ""
            },
            {
                "name": "Qiang Fu",
                "org": ""
            }
        ],
        "venue": "Applied optics",
        "year": 2005
    },
    "rZxTunzk": {
        "id": "rZxTunzk",
        "title": "Use of circular cylinders as surrogates for hexagonal pristine ice crystals in scattering calculations at infrared wavelengths.",
        "abstract": "We investigate the errors associated with the use of circular cylinders as surrogates for hexagonal columns in computing the optical properties of pristine ice crystals at infrared (8-12-microm) wavelengths. The equivalent circular cylinders are specified in terms of volume (V), projected area (A), and volume-to-area ratio that are equal to those of the hexagonal columns. We use the T-matrix method to compute the optical properties of the equivalent circular cylinders. We apply the finite-difference time-domain method to compute the optical properties of hexagonal ice columns smaller than 40 microm. For hexagonal columns larger than 40 microm we employ an improved geometric optics method and a stretched scattering potential technique developed in previous studies to calculate the phase function and the extinction (or absorption) efficiency, respectively. The differences between the results for circular cylinders and hexagonal columns are of the order of a few percent. Thus it is quite reasonable to use a circular cylinder geometry as a surrogate for pristine hexagonal ice columns for scattering calculations at infrared (8-12-microm) wavelengths. Although the pristine ice crystals can be approximated as circular cylinders in scattering calculations at infrared wavelengths, it is shown that optical properties of individual aggregates cannot be well approximated by those of individual finite columns or cylinders.",
        "keywords": [
            "atmospheric optics",
            "finite difference time domain",
            "meteorology",
            "infrared",
            "infrared spectra",
            "geometric optics",
            "light scattering",
            "atmospheric scattering"
        ],
        "authors": [
            {
                "name": "Yong-Keun Lee",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Michael I Mishchenko",
                "org": ""
            },
            {
                "name": "Bryan A Baum",
                "org": ""
            },
            {
                "name": "Yong X Hu",
                "org": ""
            },
            {
                "name": "Hung-Lung Huang",
                "org": ""
            },
            {
                "name": "Warren J Wiscombe",
                "org": ""
            },
            {
                "name": "Anthony J Baran",
                "org": ""
            }
        ],
        "venue": "Applied optics",
        "year": 2003
    },
    "eVA6o2DS": {
        "id": "eVA6o2DS",
        "title": "The MODIS Cloud Optical and Microphysical Products: Collection 6 Updates and Examples From Terra and Aqua.",
        "abstract": "The MODIS Level-2 cloud product (Earth Science Data Set names MOD06 and MYD06 for Terra and Aqua MODIS, respectively) provides pixel-level retrievals of cloud-top properties (day and night pressure, temperature, and height) and cloud optical properties (optical thickness, effective particle radius, and water path for both liquid water and ice cloud thermodynamic phases-daytime only). Collection 6 (C6) reprocessing of the product was completed in May 2014 and March 2015 for MODIS Aqua and Terra, respectively. Here we provide an overview of major C6 optical property algorithm changes relative to the previous Collection 5 (C5) product. Notable C6 optical and microphysical algorithm changes include: (i) new ice cloud optical property models and a more extensive cloud radiative transfer code lookup table (LUT) approach, (ii) improvement in the skill of the shortwave-derived cloud thermodynamic phase, (iii) separate cloud effective radius retrieval datasets for each spectral combination used in previous collections, (iv) separate retrievals for partly cloudy pixels and those associated with cloud edges, (v) failure metrics that provide diagnostic information for pixels having observations that fall outside the LUT solution space, and (vi) enhanced pixel-level retrieval uncertainty calculations. The C6 algorithm changes collectively can result in significant changes relative to C5, though the magnitude depends on the dataset and the pixel's retrieval location in the cloud parameter space. Example Level-2 granule and Level-3 gridded dataset differences between the two collections are shown. While the emphasis is on the suite of cloud optical property datasets, other MODIS cloud datasets are discussed when relevant.",
        "keywords": [
            "Aqua",
            "MOD06",
            "MYD06",
            "Moderate Resolution Imaging Spectroradiometer (MODIS)",
            "Terra",
            "cloud remote sensing",
            "clouds",
            "satellite applications",
            "terrestrial atmosphere"
        ],
        "authors": [
            {
                "name": "Steven Platnick",
                "org": "Earth Sciences Division, NASA Goddard Space Flight Center, Greenbelt, MD 20771 USA."
            },
            {
                "name": "Kerry Meyer",
                "org": "Goddard Earth Science Technology and Research, Universities Space Research Association, Columbia, MD 21046 USA."
            },
            {
                "name": "Michael D. King",
                "org": "Laboratory for Atmospheric and Space Physics, University of Colorado, Boulder, CO 80303 USA and the Texas A&M University Institute of Advanced Study."
            },
            {
                "name": "Galina Wind",
                "org": "Science Systems and Applications, Inc., Lanham, MD 20706 USA."
            },
            {
                "name": "Nandana Amarasinghe",
                "org": "Science Systems and Applications, Inc., Lanham, MD 20706 USA."
            },
            {
                "name": "Benjamin Marchant",
                "org": "Goddard Earth Science Technology and Research, Universities Space Research Association, Columbia, MD 21046 USA."
            },
            {
                "name": "G. Thomas Arnold",
                "org": "Science Systems and Applications, Inc., Lanham, MD 20706 USA."
            },
            {
                "name": "Zhibo Zhang",
                "org": "Department of Physics, University of Maryland - Baltimore County, Baltimore, MD 21250 USA."
            },
            {
                "name": "Paul A. Hubanks",
                "org": "ADNET Systems, Inc., Bethesda, MD 20817 USA."
            },
            {
                "name": "Robert E. Holz",
                "org": "Space Science and Engineering Center, University of Wisconsin - Madison, Madison, WI 53706 USA."
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77845 USA."
            },
            {
                "name": "William L. Ridgway",
                "org": "Science Systems and Applications, Inc., Lanham, MD 20706 USA."
            },
            {
                "name": "J\u00e9r\u00f4me C. Riedi",
                "org": "Laboratoire d'Optique Atmosph\u00e9rique, Universit\u00e9 de Lille - Sciences et Technologies, Villeneuve d'Ascq, France."
            }
        ],
        "venue": "IEEE Trans. Geoscience and Remote Sensing",
        "year": 2017
    },
    "08DaDKNT": {
        "id": "08DaDKNT",
        "title": "Radiative transfer simulation of dust-like aerosols: Uncertainties from particle shape and refractive index",
        "abstract": "",
        "keywords": [
            "radiative forcing",
            "mineral dust",
            "spectrum",
            "radiative transfer",
            "particle size distribution",
            "refractive index",
            "broadband",
            "far infrared"
        ],
        "authors": [
            {
                "name": "bingqi yi",
                "org": "texas a m university"
            },
            {
                "name": "christine n hsu",
                "org": "goddard space flight center"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "sichee tsay",
                "org": "goddard space flight center"
            }
        ],
        "venue": "Journal of Aerosol Science",
        "year": 2011
    },
    "p68dymYW": {
        "id": "p68dymYW",
        "title": "Time-Dependent Cryospheric Longwave Surface Emissivity Feedback in the Community Earth System Model",
        "abstract": "Author(s): Kuo, C; Feldman, DR; Huang, X; Flanner, M; Yang, P; Chen, X | Abstract: \u00a92018. American Geophysical Union. All Rights Reserved. Frozen and unfrozen surfaces exhibit different longwave surface emissivities with different spectral characteristics, and outgoing longwave radiation and cooling rates are reduced for unfrozen scenes relative to frozen ones. Here physically realistic modeling of spectrally resolved surface emissivity throughout the coupled model components of the Community Earth System Model (CESM) is advanced, and implications for model high-latitude biases and feedbacks are evaluated. It is shown that despite a surface emissivity feedback amplitude that is, at most, a few percent of the surface albedo feedback amplitude, the inclusion of realistic, harmonized longwave, spectrally resolved emissivity information in CESM1.2.2 reduces wintertime Arctic surface temperature biases from \u22127.2 \u00b1 0.9 K to \u22121.1 \u00b1 1.2 K, relative to observations. The bias reduction is most pronounced in the Arctic Ocean, a region for which Coupled Model Intercomparison Project version 5 (CMIP5) models exhibit the largest mean wintertime cold bias, suggesting that persistent polar temperature biases can be lessened by including this physically based process across model components. The ice emissivity feedback of CESM1.2.2 is evaluated under a warming scenario with a kernel-based approach, and it is found that emissivity radiative kernels exhibit water vapor and cloud cover dependence, thereby varying spatially and decreasing in magnitude over the course of the scenario from secular changes in atmospheric thermodynamics and cloud patterns. Accounting for the temporally varying radiative responses can yield diagnosed feedbacks that differ in sign from those obtained from conventional climatological feedback analysis methods.",
        "keywords": "",
        "authors": [
            {
                "name": "Chaincy Kuo",
                "org": "Climate and Ecosystem Sciences Division Lawrence Berkeley National Laboratory Berkeley CA USA"
            },
            {
                "name": "Daniel R. Feldman",
                "org": "Climate and Ecosystem Sciences Division Lawrence Berkeley National Laboratory Berkeley CA USA"
            },
            {
                "name": "Xianglei Huang",
                "org": "Department of Climate and Space Sciences and Engineering University of Michigan Ann Arbor MI USA"
            },
            {
                "name": "Mark Flanner",
                "org": "Department of Climate and Space Sciences and Engineering University of Michigan Ann Arbor MI USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences Texas A&M University College Station TX USA"
            },
            {
                "name": "Xiuhong Chen",
                "org": "Department of Climate and Space Sciences and Engineering University of Michigan Ann Arbor MI USA"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2018
    },
    "7zPfFq3u": {
        "id": "7zPfFq3u",
        "title": "Remote sensing of cirrus optical and microphysical properties from ground-based infrared radiometric Measurements-part II: retrievals from CRYSTAL-FACE measurements",
        "abstract": "",
        "keywords": [
            "relative humidity",
            "data retrieval",
            "data acquisition",
            "cloud height",
            "uncertainty",
            "remote sensing",
            "stimulated emission",
            "optical interferometry",
            "spectrum",
            "temperature",
            "radiometry",
            "atmospheric optics",
            "infrared",
            "water vapor",
            "particle size"
        ],
        "authors": [
            {
                "name": "guang guo",
                "org": "texas a m university"
            },
            {
                "name": "qiang ji",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "sichee tsay",
                "org": ""
            }
        ],
        "venue": "IEEE Geosci. Remote Sensing Lett.",
        "year": 2005
    },
    "V12evdN1": {
        "id": "V12evdN1",
        "title": "Study of the effects of phytoplankton morphology and vertical profile on lidar attenuated backscatter and depolarization ratio",
        "abstract": "Abstract   Propagation of a lidar beam in a coupled atmosphere-ocean model consisting of multiple atmospheric and upper oceanic layers and a rough ocean surface is studied by using a vectorized Monte Carlo radiative transfer solver optimized specifically for lidar-based remote sensing applications. The effects of assumed phytoplankton morphology variations and its vertical distribution on the lidar attenuated backscatter and depolarization ratio are studied. In this study, a phytoplankton particle is assumed to be a sphere, a sphere with a core, or a randomly distorted hexahedron with or without a core. The single-scattering properties of the nonspherical/inhomogeneous particles are computed using appropriate state-of-the-art light-scattering computational capabilities. Vertical variation of the phytoplankton distribution is derived explicitly using a PAR (photosynthetically active radiation) limited carbon biomass balance equation that is subsequently coupled with the Monte Carlo solver.",
        "keywords": "",
        "authors": [
            {
                "name": "Patrick G. Stegmann",
                "org": "Joint Center for Satellite Data Assimilation, NOAA Center for Weather and Climate Prediction, 5830 University Research Ct, 20740 College Park, MD, USA"
            },
            {
                "name": "Bingqiang Sun",
                "org": "Department of Atmospheric Sciences, Texas A&M University, 3150 TAMU, 77840 College Station, TX, USA"
            },
            {
                "name": "Jiachen Ding",
                "org": "Department of Atmospheric Sciences, Texas A&M University, 3150 TAMU, 77840 College Station, TX, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, 3150 TAMU, 77840 College Station, TX, USA"
            },
            {
                "name": "Xiaodong Zhang",
                "org": "Department of Earth System Science and Policy, University of North Dakota, 58202 Grand Forks, ND, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2019
    },
    "ofXZiUGM": {
        "id": "ofXZiUGM",
        "title": "A numerical combination of extended boundary condition method and invariant imbedding method applied to light scattering by large spheroids and cylinders",
        "abstract": "",
        "keywords": [
            "boundary conditions",
            "spheroids",
            "numerical analysis",
            "light scattering",
            "t matrix",
            "convergence"
        ],
        "authors": [
            {
                "name": "lei bi",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "george w kattawar",
                "org": ""
            },
            {
                "name": "michael i mishchenko",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2013
    },
    "eRRZan7L": {
        "id": "eRRZan7L",
        "title": "COMPARISON OF MODIS AND MISR TROPICAL CIRRUS RETRIEVALS",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Sarah Thomas",
                "org": ""
            },
            {
                "name": "Bryan A. Baum",
                "org": ""
            },
            {
                "name": "Shaima L. Nasiri",
                "org": ""
            },
            {
                "name": "Andrew Heymsfield",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Eugene Clothiaux",
                "org": ""
            },
            {
                "name": "David P. Kratz",
                "org": ""
            }
        ],
        "venue": "",
        "year": 0
    },
    "qv92V9Nc": {
        "id": "qv92V9Nc",
        "title": "Tunneling effects in electromagnetic wave scattering by nonspherical particles: A comparison of the Debye series and physical-geometric optics approximations",
        "abstract": "",
        "keywords": [
            "diffraction",
            "reflection",
            "tunneling"
        ],
        "authors": [
            {
                "name": "lei bi",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2015
    },
    "EZsCsHK4": {
        "id": "EZsCsHK4",
        "title": "Impact of Snow Grain Shape and Black Carbon\u2013Snow Internal Mixing on Snow Optical Properties: Parameterizations for Climate Models",
        "abstract": "AbstractA set of parameterizations is developed for spectral single-scattering properties of clean and black carbon (BC)-contaminated snow based on geometric-optics surface wave (GOS) computations, which explicitly resolves BC\u2013snow internal mixing and various snow grain shapes. GOS calculations show that, compared with nonspherical grains, volume-equivalent snow spheres show up to 20% larger asymmetry factors and hence stronger forward scattering, particularly at wavelengths u003c1 \u03bcm. In contrast, snow grain sizes have a rather small impact on the asymmetry factor at wavelengths u003c1 \u03bcm, whereas size effects are important at longer wavelengths. The snow asymmetry factor is parameterized as a function of effective size, aspect ratio, and shape factor and shows excellent agreement with GOS calculations. According to GOS calculations, the single-scattering coalbedo of pure snow is predominantly affected by grain sizes, rather than grain shapes, with higher values for larger grains. The snow single-scattering coal...",
        "keywords": "",
        "authors": [
            {
                "name": "Cenlin He",
                "org": "Department of Atmospheric and Oceanic Sciences, and Joint Institute for Regional Earth System Science and Engineering, University of California, Los Angeles, Los Angeles, California, and National Center for Atmospheric Research, Boulder, Colorado"
            },
            {
                "name": "Yoshi Takano",
                "org": "Department of Atmospheric and Oceanic Sciences, and Joint Institute for Regional Earth System Science and Engineering, University of California, Los Angeles, Los Angeles, California"
            },
            {
                "name": "Kuo-Nan Liou",
                "org": "Department of Atmospheric and Oceanic Sciences, and Joint Institute for Regional Earth System Science and Engineering, University of California, Los Angeles, Los Angeles, California"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M, College Station, Texas"
            },
            {
                "name": "Qinbin Li",
                "org": "Department of Atmospheric and Oceanic Sciences, and Joint Institute for Regional Earth System Science and Engineering, University of California, Los Angeles, Los Angeles, California"
            },
            {
                "name": "Fei Chen",
                "org": "National Center for Atmospheric Research, Boulder, Colorado"
            }
        ],
        "venue": "Journal of Climate",
        "year": 2017
    },
    "ZAi9dyQj": {
        "id": "ZAi9dyQj",
        "title": "Parameterization of shortwave cloud optical properties for a mixture of ice particle habits for use in atmospheric models: PARAMETERIZATION FOR ICE CLOUD OPTICAL PROPERTIES",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Ming-Dah Chou",
                "org": "Laboratory for Atmospheres; NASA Goddard Space Flight Center; Greenbelt Maryland USA"
            },
            {
                "name": "Kyu-Tae Lee",
                "org": "Department of Atmospheric and Environmental Science; National Kangnung University; Kangnung South Korea"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences; Texas A&M University; College Station Texas USA"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2002
    },
    "WwZpCWRJ": {
        "id": "WwZpCWRJ",
        "title": "The single-scattering properties of black carbon aggregates determined from the geometric-optics surface-wave approach and the T-matrix method",
        "abstract": "",
        "keywords": [
            "black carbon",
            "t matrix method",
            "environment"
        ],
        "authors": [
            {
                "name": "y takano",
                "org": ""
            },
            {
                "name": "k n liou",
                "org": ""
            },
            {
                "name": "michael kahnert",
                "org": ""
            },
            {
                "name": "peter yang",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2013
    },
    "durSJj7f": {
        "id": "durSJj7f",
        "title": "Effects of surface roughness on light scattering by small particles",
        "abstract": "Roughness exists on almost all natural particle surfaces, such as spores, aerosols, cells, etc. In this paper, we study the effects of surface roughness on light scattering for spherical shaped particles. A 3D finite-difference time domain model is used to solve for all the optical properties of the scatterer. We will introduce a roughness parameter and show its effect on the light scattering properties. Our results show that surface roughness can indeed play an important role on the light scattering pattern under certain conditions.",
        "keywords": [
            "aerosols",
            "scattering",
            "fdtd",
            "phase matrix",
            "finite difference time domain",
            "light scattering",
            "surface roughness"
        ],
        "authors": [
            {
                "name": "Changhui Li",
                "org": "Department of Physics, Texas A&M University, College Station, TX, USA"
            },
            {
                "name": "George W. Kattawar",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy and Radiative Transfer",
        "year": 2004
    },
    "gkn1BcHg": {
        "id": "gkn1BcHg",
        "title": "Contrails and Induced Cirrus: Optics and Radiation",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Gang Hong",
                "org": ""
            },
            {
                "name": "Andrew E. Dessler",
                "org": ""
            },
            {
                "name": "Steve S. C. Ou",
                "org": ""
            },
            {
                "name": "Kuo-Nan Liou",
                "org": ""
            },
            {
                "name": "Patrick Minnis",
                "org": ""
            },
            {
                "name": "Harshvardhan",
                "org": ""
            }
        ],
        "venue": "Bulletin of The American Meteorological Society",
        "year": 2010
    },
    "ebB2STbO": {
        "id": "ebB2STbO",
        "title": "MODIS Cloud-Top Property Refinements for Collection 6",
        "abstract": "",
        "keywords": [
            "remote sensing"
        ],
        "authors": [
            {
                "name": "bryan a baum",
                "org": ""
            },
            {
                "name": "w paul menzel",
                "org": ""
            },
            {
                "name": "r frey",
                "org": ""
            },
            {
                "name": "david c tobin",
                "org": ""
            },
            {
                "name": "robert e holz",
                "org": ""
            },
            {
                "name": "steve ackerman",
                "org": ""
            },
            {
                "name": "andrew k heidinger",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            }
        ],
        "venue": "Journal of Applied Meteorology and Climatology",
        "year": 2012
    },
    "OMMkBaza": {
        "id": "OMMkBaza",
        "title": "Single-scattering properties of tri-axial ellipsoidal mineral dust aerosols: A database for application to radiative transfer calculations",
        "abstract": "This paper presents a user-friendly database software package of the single-scattering properties of individual dust-like aerosol particles for application to radiative transfer calculations in a spectral region from ultraviolet (UV) to far-infrared (far-IR). To expand the degree of morphological freedom of the commonly used spheroidal and spherical models, tri-axial ellipsoids were assumed to be the overall shape of dust-like aerosol particles. A combination of four computational methods, including the Lorenz-Mie theory, the T-matrix method, the discrete dipole approximation, and an improved geometric optics method, was employed to compute the phase matrix, extinction efficiency and single-scattering albedo of ellipsoids with various aspect ratios and sizes. The scattering property database was developed for 42 particle shapes specified in terms of two aspect ratios, 69 refractive indices and 471 size parameters. Additionally, accompanying software, based on interpolation, was developed to provide the single- scattering properties for user-specified aspect ratios, refractive indices and size parameters. The software package allows for the derivation of the bulk optical properties for a given distribution of particle microphysical parameters (i.e., refractive index, size parameter and two aspect ratios). The array-oriented single-scattering property data sets are stored in the NetCDF format.",
        "keywords": [
            "dust aerosol optical properties database",
            "mineral dust",
            "geometric optics",
            "refractive index",
            "discrete dipole approximation",
            "database",
            "far infrared",
            "radiative transfer",
            "aspect ratio",
            "mie theory"
        ],
        "authors": [
            {
                "name": "Zhaokai Meng",
                "org": "Department of Physics|Texas A&M University"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences|Texas A&M University"
            },
            {
                "name": "George W. Kattawar",
                "org": "Department of Physics|Texas A&M University"
            },
            {
                "name": "Lei Bi",
                "org": "Department of Physics|Texas A&M University"
            },
            {
                "name": "K. N. Liou",
                "org": "Joint Institute for Regional Earth System Science and Engineering|Department of Atmospheric and Oceanic Sciences|University of California , Los Angeles"
            },
            {
                "name": "Istvan Laszlo",
                "org": "Center for Satellite Applications and Research"
            }
        ],
        "venue": "Journal of Aerosol Science",
        "year": 2010
    },
    "KkzehQE4": {
        "id": "KkzehQE4",
        "title": "A new approach to retrieving cirrus cloud height with a combination of MODIS 1.24\u2010 and 1.38\u2010\u03bcm channels",
        "abstract": "",
        "keywords": [
            "cloud height"
        ],
        "authors": [
            {
                "name": "chenxi wang",
                "org": "texas a m university"
            },
            {
                "name": "shouguo ding",
                "org": "texas a m university"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "bryan a baum",
                "org": "university of wisconsin madison"
            },
            {
                "name": "a e dessler",
                "org": "texas a m university"
            }
        ],
        "venue": "Geophysical Research Letters",
        "year": 2012
    },
    "GzPxdQzT": {
        "id": "GzPxdQzT",
        "title": "Physical and optical properties of persistent contrails: Climatology and interpretation: CONTRAIL PROPERTIES",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Hironobu Iwabuchi",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "K. N. Liou",
                "org": ""
            },
            {
                "name": "Patrick Minnis",
                "org": ""
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2012
    },
    "rigKDFCp": {
        "id": "rigKDFCp",
        "title": "Retrieval of Cloud Microphysical Properties from MODIS and AIRS",
        "abstract": "",
        "keywords": [
            "spectral resolution",
            "infrared",
            "spatial resolution",
            "carbon dioxide",
            "particle size",
            "radiative transfer model"
        ],
        "authors": [
            {
                "name": "Jun Li",
                "org": ""
            },
            {
                "name": "Hung-Lung Huang",
                "org": ""
            },
            {
                "name": "Chian-Yi Liu",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Timothy J. Schmit",
                "org": ""
            },
            {
                "name": "Heli Wei",
                "org": ""
            },
            {
                "name": "Elisabeth Weisz",
                "org": ""
            },
            {
                "name": "Li Guan",
                "org": ""
            },
            {
                "name": "W. Paul Menzel",
                "org": ""
            }
        ],
        "venue": "Journal of Applied Meteorology",
        "year": 2005
    },
    "Ei8p0P1z": {
        "id": "Ei8p0P1z",
        "title": "Study of Horizontally Oriented Ice Crystals with CALIPSO Observations and Comparison with Monte Carlo Radiative Transfer Simulations",
        "abstract": "",
        "keywords": [
            "particulates",
            "radiative transfer"
        ],
        "authors": [
            {
                "name": "chen zhou",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "a e dessler",
                "org": ""
            },
            {
                "name": "yongxiang hu",
                "org": ""
            },
            {
                "name": "bryan a baum",
                "org": ""
            }
        ],
        "venue": "Journal of Applied Meteorology and Climatology",
        "year": 2012
    },
    "Ly4TgDmw": {
        "id": "Ly4TgDmw",
        "title": "Impact of calcification state on the inherent optical properties of Emiliania huxleyi coccoliths and coccolithophores",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "lei bi",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2015
    },
    "xw4ezZJt": {
        "id": "xw4ezZJt",
        "title": "A High-Spectral-Resolution Radiative Transfer Model for Simulating Multilayered Clouds and Aerosols in the Infrared Spectral Region",
        "abstract": "",
        "keywords": [
            "radiative transfer"
        ],
        "authors": [
            {
                "name": "chenxi wang",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "xu liu",
                "org": ""
            }
        ],
        "venue": "Journal of the Atmospheric Sciences",
        "year": 2015
    },
    "hxQczviK": {
        "id": "hxQczviK",
        "title": "Internal dipole radiation as a tool for particle identification.",
        "abstract": "A numerical approach for the calculation of the internal dipole radiation associated with particles of arbitrary morphology is investigated by using the discrete-dipole approximation (DDA) method. The DDA and analytical solutions for the total radiated power and radiation pattern are compared in the case of spherical host particles. It is shown that the DDA can be quite accurate under the condition that m <or approximately 2, and mkd<0.5, where m is the refractive index of the host particle, k=2pi/lambda is the wavenumber in vacuum, and d is the distance between two adjacent dipoles in the DDA cubic dipole array. Furthermore, the DDA solutions for the dipole radiation patterns associated with nonspherical host particles are compared with their corresponding counterparts obtained from the finite-difference time-domain method. Excellent agreement between the two results is noted. The DDA method is also applied to the computation of the internal dipole radiation associated with simulated nonspherical sporelike particles. The results suggest that the internal dipole radiation patterns contain a great deal of information about the morphology and composition of the host particle.",
        "keywords": [
            "radiation",
            "analytic solution",
            "discrete dipole approximation",
            "refractive index",
            "radiation pattern"
        ],
        "authors": [
            {
                "name": "Yu You",
                "org": ""
            },
            {
                "name": "George W Kattawar",
                "org": ""
            },
            {
                "name": "Changhui Li",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            }
        ],
        "venue": "Applied optics",
        "year": 2006
    },
    "jlLhHIAy": {
        "id": "jlLhHIAy",
        "title": "Impact of pollution on the optical properties of trans\u2010Pacific East Asian dust from satellite and ground\u2010based measurements",
        "abstract": "",
        "keywords": [
            "satellite",
            "pollution"
        ],
        "authors": [
            {
                "name": "bingqi yi",
                "org": "texas a m university"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "bryan a baum",
                "org": "university of wisconsin madison"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2014
    },
    "v5FKKflP": {
        "id": "v5FKKflP",
        "title": "Diel variations of the attenuation, backscattering and absorption coefficients of four phytoplankton species and comparison with spherical, coated spherical and hexahedral particle optical models",
        "abstract": "Abstract   Diel variations of inherent optical properties (absorption coefficient, attenuation coefficient and volume scattering function at 124\u00b0) of four species of phytoplankton were measured in the laboratory and were simulated using a homogeneous spherical model, a coated spherical model and a homogeneous hexahedral model. The required inputs to run each optical model were acquired from the measurements; the real and imaginary parts of the refractive index were determined from the intracellular carbon and absorption coefficient, and particle size distributions from the Coulter counter. We conducted a sensitivity analysis on the inherent optical properties in response to changes in the slope of Junge distributions that were used to represent non-phytoplankton particles of radii less than 1.12\u202f\u00b5m (the minimum size of the Coulter counter), realistic maximum and minimum values of the refractive indices used for the shell and core, shell thickness, cell radius and the number of cells. We found that the shellu0027s refractive index is the most important factor influencing the backscattering ratio. We found that the coated spherical model reproduced the observed optical properties best for all species possessing a shell. The hexahedral and homogenous spherical models give relatively good results for the absorption and attenuation coefficients; but underestimated the volume scattering function at 124\u00b0. Correlations between the measured backscattering cross sections and carbon are significant only for  E. huxleyi  and  D. tertiolecta . In situ measurements will be necessary to determine if our models can reproduce the diel variations of backscattering that are observed in the ocean.",
        "keywords": "",
        "authors": [
            {
                "name": "Carina Poulin",
                "org": "Universit\u00e9 de Sherbrooke, 2500, boulevard de l'Universit\u00e9, Sherbrooke, Qu\u00e9bec J1K 2R1, Canada"
            },
            {
                "name": "Xiaodong Zhang",
                "org": "University of North Dakota, Clifford Hall Room 326, 4149 University Ave Stop 9011, Grand Forks, North Dakota 58202-9011, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, TAMU-3150, College Station, Texas 77843, USA"
            },
            {
                "name": "Yannick Huot",
                "org": "Universit\u00e9 de Sherbrooke, 2500, boulevard de l'Universit\u00e9, Sherbrooke, Qu\u00e9bec J1K 2R1, Canada"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2018
    },
    "jTkAVhTw": {
        "id": "jTkAVhTw",
        "title": "Retrieval of polar stratospheric cloud microphysical properties from lidar measurements: Dependence on particle shape assumptions",
        "abstract": "Computational simulations have been performed to deduce the dependence of the microphysical analysis of polar stratospheric cloud (PSC) optical data measured with lidar on the assumptions made about particle shape. In a forward model, PSCs are modeled as crystalline and liquid particles in order to generate synthetic optical properties. The parameterization scheme of the PSC microphysical properties allows for coexistence of up to three different particle types with size-dependent shapes; optical properties of individual crystals, specifically hexagonal and asymmetric polyhedral crystals, are determined using the finite difference time domain (FDTD) method. The set of calculated PSC optical properties is selected based on the wavelengths and measurement capabilities of lidar instruments that are typically used to monitor stratospheric aerosols, such as the Airborne Raman Ozone and Temperature Lidar (AROTEL) and the NASA Langley Differential Absorption Lidar (DIAL) onboard the NASA DC-8 during the Stratospheric Aerosol and Gas Experiment (SAGE) Ozone Loss Validation Experiment (SOLVE) campaign in winter 1999/2000. The retrieval process then inverts these synthetic measurement data using a model approach in which the PSC particles are represented purely by an ensemble of spheroids, and the differences between initial and retrieved microphysical properties are examined. The model simulations show that under the assumption of spheroidal particle shapes, surface area density and volume density of leewave PSCs are systematically smaller by, respectively, \u223c10\u201330% and \u223c5\u201325% than the values found for mixtures of droplets, asymmetric polyhedra, and hexagons.",
        "keywords": [
            "shapes",
            "crystals",
            "backscattering",
            "ozone",
            "finite difference time domain",
            "stratosphere",
            "depolarization",
            "spheroids",
            "mathematical models",
            "computer simulation",
            "surface area"
        ],
        "authors": [
            {
                "name": "jens reichardt",
                "org": "goddard space flight center"
            },
            {
                "name": "susanne reichardt",
                "org": "goddard space flight center"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "thomas j mcgee",
                "org": "goddard space flight center"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2002
    },
    "glAPZZ9t": {
        "id": "glAPZZ9t",
        "title": "Uncertainties Associated With the Surface Texture of Ice Particles in Satellite-Based Retrieval of Cirrus Clouds\u2014Part I: Single-Scattering Properties of Ice Crystals With Surface Roughness",
        "abstract": "Surface roughness of ice crystals is a morphological parameter important to the scattering characteristics of these particles. The intent of this paper, reported in two parts (hereafter, Parts I and II), is to investigate the accuracy associated with some simplifications in calculating the single-scattering properties of roughened ice crystals and to quantify the effect of surface roughness on the retrieval of the optical and microphysical properties of ice clouds from satellite observations. In Part I, two ray-tracing schemes, a rigorous algorithm and an approximate algorithm with a simplified treatment of surface roughness, are employed to calculate the single-scattering properties of randomly oriented hexagonal ice crystals with size parameters in the geometric optics regime. With the rigorous approach, it requires substantial computational effort to accurately account for the multiple external reflections between various roughness facets and the reentries of outgoing rays into the particles in the ray-tracing computation. With the simplified ray-tracing scheme, the ray-tracing calculation for roughened particles is similar to that for smooth particles except that, in the former case, the normal of the particle surface is statistically perturbed for each reflection-refraction event. The simplified ray-tracing scheme can account for most the effects of surface roughness on particle single-scattering properties without incurring substantial demand on computational resources and, thus, provides an efficient way to compute the single-scattering properties of roughened particles. The effect of ice-crystal surface roughness on the retrieval of the optical thicknesses and effective particle sizes of cirrus clouds is reported in Part II.",
        "keywords": [
            "remote sensing",
            "ice cloud microphysical properties",
            "atmospheric techniques",
            "atmospheric optics",
            "surface roughness",
            "geometric optics",
            "light scattering",
            "hexagonal ice crystals",
            "ice crystals",
            "ray tracing",
            "ray tracing schemes",
            "surface texture",
            "cirrus cloud effective particle size",
            "ice crystal single scattering properties",
            "cirrus cloud optical thickness",
            "atmospheric precipitation",
            "ice cloud optical properties",
            "clouds",
            "ice",
            "ray-tracing",
            "ice crystal scattering characteristics",
            "ice particle surface texture",
            "satellite based cirrus cloud retrieval",
            "ice crystal surface roughness",
            "crystals",
            "optical scattering",
            "uncertainty",
            "rough surfaces",
            "particle size"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "George W. Kattawar",
                "org": ""
            },
            {
                "name": "Gang Hong",
                "org": ""
            },
            {
                "name": "Patrick Minnis",
                "org": ""
            },
            {
                "name": "Yongxiang Hu",
                "org": ""
            }
        ],
        "venue": "IEEE T. Geoscience and Remote Sensing",
        "year": 2008
    },
    "m4KGRQP5": {
        "id": "m4KGRQP5",
        "title": "Light scattering by hexagonal ice crystals with distributed inclusions",
        "abstract": "Abstract   Inclusions of air bubbles or soot particles have significant effects on the single-scattering properties of ice crystals, effects that in turn have significant impacts on the radiation budget of an atmosphere containing the crystals. This study investigates some of the single-scattering effects in the case of hexagonal ice crystals, including effects on the backscattering depolarization ratio, a quantity of practical importance in the interpretation of lidar observations. One distinguishing feature of the study is an investigation of scattering properties at a visible wavelength for a crystal with size parameter ( x ) above 100, a size regime where one expects some agreement between exact methods and geometrical optics methods. This expectation is generally borne out in a test comparison of how the sensitivity of scattering properties to the distribution of a given volume fraction of included air is represented using (i) an approximate Monte Carlo Ray Tracing (MCRT) method and (ii) a numerically exact pseudo-spectral time-domain (PSTD) method. Another distinguishing feature of the study is a close examination, using the numerically exact Invariant-Imbedding T-Matrix (II-TM) method, of how some optical properties of importance to satellite remote sensing vary as the volume fraction of inclusions and size of crystal are varied. Although such an investigation of properties in the  x u003e100 regime faces serious computational burdens that force a large number of idealizations and simplifications in the study, the results nevertheless provide an intriguing glimpse of what is evidently a quite complex sensitivity of optical scattering properties to inclusions of air or soot as volume fraction and size parameter are varied.",
        "keywords": "",
        "authors": [
            {
                "name": "R. Lee Panetta",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Jianing Zhang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Lei Bi",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Guanlin Tang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2016
    },
    "9iNrQH2l": {
        "id": "9iNrQH2l",
        "title": "Improvements on the ice cloud modeling capabilities of the Community Radiative Transfer Model",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Bingqi Yi",
                "org": "Department of Atmospheric Sciences Texas A&M University College Station Texas USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences Texas A&M University College Station Texas USA"
            },
            {
                "name": "Quanhua Liu",
                "org": "ESSIC University of Maryland College Park Maryland USA"
            },
            {
                "name": "Paul van Delst",
                "org": "Joint Center for Satellite Data Assimilation College Park Maryland USA"
            },
            {
                "name": "Sid-Ahmed Boukabara",
                "org": "Joint Center for Satellite Data Assimilation College Park Maryland USA"
            },
            {
                "name": "Fuzhong Weng",
                "org": "NOAA/NESDIS/STAR College Park Maryland USA"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2016
    },
    "2L2KzCOC": {
        "id": "2L2KzCOC",
        "title": "Estimation of the cirrus cloud scattering phase function from satellite observations",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "chenxi wang",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "a e dessler",
                "org": ""
            },
            {
                "name": "bryan a baum",
                "org": ""
            },
            {
                "name": "yongxiang hu",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2014
    },
    "kO6T2m2Y": {
        "id": "kO6T2m2Y",
        "title": "Accurate simulation of the optical properties of atmospheric ice crystals with the invariant imbedding T-matrix method",
        "abstract": "",
        "keywords": [
            "ice crystal",
            "t matrix",
            "light scattering"
        ],
        "authors": [
            {
                "name": "lei bi",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2014
    },
    "L2zMC9bP": {
        "id": "L2zMC9bP",
        "title": "The Development of Midlatitude Cirrus Models for MODIS Using FIRE-I, FIRE-II, and ARM In Situ Data",
        "abstract": "Detailed in situ data from cirrus clouds have been collected during dedicated field campaigns, but the use of the size and habit distribution data has been lagging in the development of more realistic cirrus scattering models. In this study, the authors examine the use of in situ cirrus data collected during three field campaigns to develop more realistic midlatitude cirrus microphysical models. Data are used from the First International Satellite Cloud Climatology Project (ISCCP) Regional Experiment (FIRE)-I (1986) and FIRE-II (1991) campaigns and from a recent Atmospheric Radiation Measurement (ARM) Program campaign held in March-April of 2000. The microphysical models are based on measured vertical distributions of both particle size and particle habit and are used to develop new scattering models for a suite of moderate-resolution imaging spectoradiometer (MODIS) bands spanning visible, near-infrared, and infrared wavelengths. The sensitivity of the resulting scattering prop- erties to the underlying assumptions of the assumed particle size and habit distributions are examined. It is found that the near-infrared bands are sensitive not only to the discretization of the size distribution but also to the assumed habit distribution. In addition, the results indicate that the effective diameter calculated from a given size distribution tends to be sensitive to the number of size bins that are used to discretize the data and also to the ice-crystal habit distribution.",
        "keywords": [],
        "authors": [
            {
                "name": "Shaima L. Nasiri",
                "org": ""
            },
            {
                "name": "Bryan A. Baum",
                "org": ""
            },
            {
                "name": "Andrew J. Heymsfield",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Michael R. Poellot",
                "org": ""
            },
            {
                "name": "David P. Kratz",
                "org": ""
            },
            {
                "name": "Yongxiang Hu",
                "org": ""
            }
        ],
        "venue": "Journal of Applied Meteorology",
        "year": 2002
    },
    "kyNNVvyt": {
        "id": "kyNNVvyt",
        "title": "Impact of Multiple Scattering on Longwave Radiative Transfer Involving Clouds",
        "abstract": "Author(s): Kuo, CP; Yang, P; Huang, X; Feldman, D; Flanner, M; Kuo, C; Mlawer, EJ | Abstract: \u00a9 2017. The Authors. General circulation models (GCMs) are extensively used to estimate the influence of clouds on the global energy budget and other aspects of climate. Because radiative transfer computations involved in GCMs are costly, it is typical to consider only absorption but not scattering by clouds in longwave (LW) spectral bands. In this study, the flux and heating rate biases due to neglecting the scattering of LW radiation by clouds are quantified by using advanced cloud optical property models, and satellite data from Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO), CloudSat, Clouds and the Earthu0027s Radiant Energy System (CERES), and Moderate Resolution Imaging Spectrometer (MODIS) merged products (CCCM). From the products, information about the atmosphere and clouds (microphysical and buck optical properties, and top and base heights) is used to simulate fluxes and heating rates. One-year global simulations for 2010 show that the LW scattering decreases top-of-atmosphere (TOA) upward flux and increases surface downward flux by 2.6 and 1.2 W/m2, respectively, or approximately 10% and 5% of the TOA and surface LW cloud radiative effect, respectively. Regional TOA upward flux biases are as much as 5% of global averaged outgoing longwave radiation (OLR). LW scattering causes approximately 0.018 K/d cooling at the tropopause and about 0.028 K/d heating at the surface. Furthermore, over 40% of the total OLR bias for ice clouds is observed in 350\u2013500 cm\u22121. Overall, the radiative effects associated with neglecting LW scattering are comparable to the counterpart due to doubling atmospheric CO2 under clear-sky conditions.",
        "keywords": "",
        "authors": [
            {
                "name": "Chia Pang Kuo",
                "org": "Department of Atmospheric SciencesTexas A&M UniversityCollege Station TX USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric SciencesTexas A&M UniversityCollege Station TX USA"
            },
            {
                "name": "Xianglei Huang",
                "org": "Department of Atmospheric, Oceanic, and Space SciencesUniversity of MichiganAnn Arbor MI USA"
            },
            {
                "name": "Daniel R. Feldman",
                "org": "Lawrence Berkeley National LaboratoryBerkeley CA USA"
            },
            {
                "name": "Mark G. Flanner",
                "org": "Department of Atmospheric, Oceanic, and Space SciencesUniversity of MichiganAnn Arbor MI USA"
            },
            {
                "name": "Chaincy Kuo",
                "org": ""
            },
            {
                "name": "Eli J. Mlawer",
                "org": "Atmospheric and Environmental Research, IncCambridge MA USA"
            }
        ],
        "venue": "Journal of Advances in Modeling Earth Systems",
        "year": 2017
    },
    "xr5zSQPb": {
        "id": "xr5zSQPb",
        "title": "An efficient method for computing atmospheric radiances in clear-sky and cloudy conditions",
        "abstract": "Research Highlight \u25baA computationally efficient model is developed to simulate radiance. \u25baThe spectral region ranges from visible to far-infrared with a resolution of 1 cm \u22121 . \u25baThe relative errors of this model are less than 2% for clear-sky conditions. \u25baThe RMS errors of this model are within the noise range of a typical sensor.",
        "keywords": [
            "computationally efficient method",
            "multiple scattering",
            "spectral radiances",
            "far infrared",
            "infrared",
            "spectral resolution",
            "radiative transfer",
            "root mean square",
            "brightness temperature"
        ],
        "authors": [
            {
                "name": "Xiuhong Chen",
                "org": "Key Laboratory of Atmospheric Composition and Optical Radiation, Anhui Institute of Optics and Fine Mechanics, the Chinese Academy of Sciences, P.O. Box 1125, Hefei, Anhui 230031, China"
            },
            {
                "name": "Heli Wei",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Zhonghai Jin",
                "org": "AS&M, Incorporated, Hampton, VA 23666, USA"
            },
            {
                "name": "Bryan A. Baum",
                "org": "Space Science and Engineering Center, University of Wisconsin Madison, Madison, WI 53706, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy and Radiative Transfer",
        "year": 2011
    },
    "vOsL61sJ": {
        "id": "vOsL61sJ",
        "title": "Application of the pseudo-spectral time domain method to compute particle single-scattering properties for size parameters up to 200",
        "abstract": "",
        "keywords": [
            "pseudo spectral method",
            "scattering",
            "time domain"
        ],
        "authors": [
            {
                "name": "chao liu",
                "org": ""
            },
            {
                "name": "r lee panetta",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2012
    },
    "WmuBFgeh": {
        "id": "WmuBFgeh",
        "title": "Truncation of the scattering phase matrix for vector radiative transfer simulation",
        "abstract": "Abstract   This short communication interprets the delta-fit technique in a context of similarity transformation and the correction to the source function, and derives the analogous form of the method to be applied for the scattering phase matrix. To adapt the delta-fit method to vector radiative transfer, the mathematically exact form of the similarity principle is used in the theoretical development. Some examples of relevant radiative transfer simulations are also presented for atmospheric ice particles. The performance of the adopted delta-fit method is comparable to the delta-M method with single scattering correction except for worse delta-fit performance for polarized radiance calculations in forward directions.",
        "keywords": "",
        "authors": [
            {
                "name": "Souichiro Hioki",
                "org": "Texas A&M University, College Station, TX, United States"
            },
            {
                "name": "Ping Yang",
                "org": "Texas A&M University, College Station, TX, United States"
            },
            {
                "name": "George W. Kattawar",
                "org": "Texas A&M University, College Station, TX, United States"
            },
            {
                "name": "Yongxiang Hu",
                "org": "Climate Science Branch, NASA Langley Research Center, Hampton, VA, Unites States"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2016
    },
    "rxn8Mi1u": {
        "id": "rxn8Mi1u",
        "title": "Retrieval of Ice Cloud Properties Using Variable Phase Functions",
        "abstract": "An enhancement to NASA Langley's Visible Infrared Solar-infrared Split-window Technique (VISST) is developed to identify and account for situations when errors are induced by using smooth ice crystals. The retrieval scheme incorporates new ice cloud phase functions that utilize hexagonal crystals with roughened surfaces. In some situations, cloud optical depths are reduced, hence, cloud height is increased. Cloud effective particle size also changes with the roughened ice crystal models which results in varied effects on the calculation of ice water path. Once validated and expanded, the new approach will be integrated in the CERES MODIS algorithm and real-time retrievals at Langley.",
        "keywords": [
            "pacs: 92.60.mt?",
            "infrared",
            "particle size",
            "radiative transfer",
            "adaptive system",
            "real time",
            "remote sensing"
        ],
        "authors": [
            {
                "name": "Patrick W. Heck",
                "org": "University of Wisconsin-Madison"
            },
            {
                "name": "Patrick Minnis",
                "org": "Climate Sciences Branch|NASA Langley Research Center"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences|Texas A&M University"
            },
            {
                "name": "Fu-Lung Chang",
                "org": "National Institute of Aerospace"
            },
            {
                "name": "Rabindra Palikonda",
                "org": "Science Systems and Applications , Inc"
            },
            {
                "name": "Robert F. Arduini",
                "org": "Science Systems and Applications , Inc"
            },
            {
                "name": "Sunny Sun-Mack",
                "org": "Science Systems and Applications , Inc"
            }
        ],
        "venue": "",
        "year": 2009
    },
    "f09dXjlr": {
        "id": "f09dXjlr",
        "title": "Bulk Scattering Properties for the Remote Sensing of Ice Clouds. Part II: Narrowband Models",
        "abstract": "",
        "keywords": [
            "remote sensing",
            "particle size",
            "particle size distribution",
            "international satellite cloud climatology project"
        ],
        "authors": [
            {
                "name": "andrew j heymsfield",
                "org": "langley research center"
            },
            {
                "name": "bryan a baum",
                "org": "texas a m university"
            },
            {
                "name": "sarah t bedka",
                "org": "national center for atmospheric research"
            },
            {
                "name": "michael d king",
                "org": "goddard space flight center"
            },
            {
                "name": "y x hu",
                "org": "goddard space flight center"
            },
            {
                "name": "steven platnick",
                "org": "langley research center"
            },
            {
                "name": "ping yang",
                "org": "cooperative institute for meteorological satellite studies"
            }
        ],
        "venue": "Journal of Applied Meteorology",
        "year": 2005
    },
    "JssnWMP2": {
        "id": "JssnWMP2",
        "title": "Q-space analysis of light scattering by ice crystals",
        "abstract": "Abstract   Q-space analysis is applied to extensive simulations of the single-scattering properties of ice crystals with various habits/shapes over a range of sizes. The analysis uncovers features common to all the shapes: a forward scattering regime with intensity quantitatively related to the Rayleigh scattering by the particle and the internal coupling parameter, followed by a Guinier regime dependent upon the particle size, a complex power law regime with incipient two dimensional diffraction effects, and, in some cases, an enhanced backscattering regime. The effects of significant absorption on the scattering profile are also studied. The overall features found for the ice crystals are similar to features in scattering from same sized spheres.",
        "keywords": "",
        "authors": [
            {
                "name": "Yuli W. Heinson",
                "org": "Department of Physics, Kansas State University, Manhattan, KS 66506, USA"
            },
            {
                "name": "Justin B. Maughan",
                "org": "Department of Physics, Kansas State University, Manhattan, KS 66506, USA"
            },
            {
                "name": "Jiachen Ding",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Amitabha Chakrabarti",
                "org": "Department of Physics, Kansas State University, Manhattan, KS 66506, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Christopher M. Sorensen",
                "org": "Department of Physics, Kansas State University, Manhattan, KS 66506, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2016
    },
    "jGgYKzga": {
        "id": "jGgYKzga",
        "title": "Seasonal and global variations of water vapor and high clouds observed with MODIS near-IR channels",
        "abstract": "",
        "keywords": [
            "imaging spectrometer",
            "seasonality",
            "physical oceanography",
            "seasonal variation",
            "scientific data",
            "frequencies",
            "spectrometers",
            "absorption",
            "remote sensing",
            "water vapor",
            "water",
            "near infrared"
        ],
        "authors": [
            {
                "name": "bocai gao",
                "org": "united states naval research laboratory"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "yoram j kaufman",
                "org": "goddard space flight center"
            },
            {
                "name": "warren j wiscombe",
                "org": "goddard space flight center"
            },
            {
                "name": "william k m lau",
                "org": "united states naval research laboratory"
            }
        ],
        "venue": "",
        "year": 2003
    },
    "pYPRR689": {
        "id": "pYPRR689",
        "title": "PARAMETERIZATIONS OF SOLAR SINGLE-SCATTERING RADIATIVE PROPERTIES FOR TROPICAL ICE CLOUDS",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Greg M. McFarquhar",
                "org": "University of Illinois at Urbana-Champaign"
            },
            {
                "name": "Ping Yang",
                "org": "Texas A&M University"
            },
            {
                "name": "Andreas Macke",
                "org": "University of Kiel"
            },
            {
                "name": "Anthony Baran",
                "org": ""
            },
            {
                "name": "Sam Iacobellis",
                "org": "Scripps Institution of Oceanography"
            },
            {
                "name": "Richard Somerville",
                "org": "Scripps Institution of Oceanography"
            }
        ],
        "venue": "",
        "year": 0
    },
    "ze9MkONX": {
        "id": "ze9MkONX",
        "title": "Net radiative effects of dust in the tropical North Atlantic based on integrated satellite observations and in situ measurements",
        "abstract": "Abstract.  In this study, we integrate recent in situ measurements with satelliteretrievals of dust physical  radiative properties to quantify dustdirect radiative effects on shortwave (SW)  longwave (LW) radiation(denoted as DRE  SW    DRE  LW  , respectively) in the tropical NorthAtlantic during the summer months from 2007 to 2010. Through linear regression ofthe CERES-measured top-of-atmosphere (TOA) flux versus satellite aerosol opticaldepth (AOD) retrievals, we estimate the instantaneous DRE  SW   efficiencyat the TOA to be     -  49.7  \u00b1  7.1           W  m  \u22122    AOD  \u22121   and    -  36.5  \u00b1  4.8           W  m  \u22122    AOD  \u22121   based on AOD from MODIS  CALIOP,respectively. We then perform various sensitivity studies based on recentmeasurements of dust particle size distribution (PSD), refractive index, andparticle shape distribution to determine how the dust microphysical andoptical properties affect DRE estimates  its agreement with the above-mentionedsatellite-derived DREs. Our analysis shows that a good agreement with theobservation-based estimates of instantaneous DRE  SW    DRE  LW   can beachieved through a combination of recently observed PSD with substantialpresence of coarse particles, a less absorptive SW refractive index, andspheroid shapes. Based on this optimal combination of dust physicalproperties we further estimate the diurnal mean dust DRE  SW   in the regionof  \u221210   W  m  \u22122   at TOA   \u221226   W  m  \u22122   at the surface, respectively, ofwhich  \u223c   30  % is canceled out by the positive DRE  LW  . Thisyields a net DRE of about  \u22126.9    \u221218.3   W  m  \u22122   at TOA  the surface, respectively. Our study suggests that the LW flux contains usefulinformation on dust particle size, which could be used together with SWobservations to achieve a more holistic understanding of the dust radiativeeffect.",
        "keywords": "",
        "authors": [
            {
                "name": "Qianqian Song",
                "org": "Physics Department, University of Maryland Baltimore County, Baltimore, Maryland, USA"
            },
            {
                "name": "Qianqian Song",
                "org": "Physics Department, University of Maryland Baltimore County, Baltimore, Maryland, USA"
            },
            {
                "name": "Zhibo Zhang",
                "org": ""
            },
            {
                "name": "Zhibo Zhang",
                "org": ""
            },
            {
                "name": "Hongbin Yu",
                "org": ""
            },
            {
                "name": "Seiji Kato",
                "org": "NASA Langley Research Center, Hampton, Virginia"
            },
            {
                "name": "Ping Yang",
                "org": "Dept. of Atmospheric Sciences, Texas A&M University, College Station, Texas, USA"
            },
            {
                "name": "Peter R. Colarco",
                "org": "NASA Goddard Space Flight Center, Greenbelt, Maryland, USA"
            },
            {
                "name": "Lorraine A. Remer",
                "org": "Joint Center for Earth Systems Technology, University of Maryland Baltimore#N#County, Baltimore, Maryland, USA"
            },
            {
                "name": "Claire L. Ryder",
                "org": "Department of Meteorology, University of Reading, RG6 6BB, UK"
            }
        ],
        "venue": "Atmospheric Chemistry and Physics",
        "year": 2018
    },
    "dbCJDbqp": {
        "id": "dbCJDbqp",
        "title": "Retrieval of ice cloud properties using an optimal estimation algorithm and MODIS infrared observations: 2. Retrieval evaluation",
        "abstract": "An infrared-based optimal estimation (OE-IR) algorithm for retrieving ice cloud properties is evaluated. Specifically, the implementation of the algorithm with MODerate resolution Imaging Spectroradiometer (MODIS) observations is assessed in comparison with the operational retrieval products from MODIS on the Aqua satellite (MYD06), Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP), and the Imaging Infrared Radiometer (IIR); the latter two instruments fly on the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) satellite in the Afternoon Constellation (A-Train) with Aqua. The results show that OE-IR cloud optical thickness (tau) and effective radius (r(sub eff)) retrievals perform best for ice clouds having 0.5   1km) occurs for tau u003c 0.5. Analysis of 1month of the OE-IR retrievals shows large tau and r(sub eff) uncertainties in storm track regions and the southern oceans where convective clouds are frequently observed, as well as in high-latitude regions where temperature differences between the surface and cloud top are more ambiguous. Generally, comparisons between the OE-IR and the operational products show consistent tau and h retrievals. However, obvious differences between the OE-IR and the MODIS Collection 6 r(sub eff) are found.",
        "keywords": "",
        "authors": [
            {
                "name": "Chenxi Wang",
                "org": "Earth System Science Interdisciplinary Center University of Maryland College Park Maryland USA"
            },
            {
                "name": "Steven Platnick",
                "org": "NASA Goddard Space Flight Center Greenbelt Maryland USA"
            },
            {
                "name": "Zhibo Zhang",
                "org": "Department of Physics University of Maryland, Baltimore County Baltimore Maryland USA"
            },
            {
                "name": "Kerry Meyer",
                "org": "NASA Goddard Space Flight Center Greenbelt Maryland USA"
            },
            {
                "name": "Kerry Meyer",
                "org": "NASA Goddard Space Flight Center Greenbelt Maryland USA"
            },
            {
                "name": "Galina Wind",
                "org": "NASA Goddard Space Flight Center Greenbelt Maryland USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences Texas A&M University College Station Texas USA"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2016
    },
    "w7fLajoS": {
        "id": "w7fLajoS",
        "title": "Cloud Property Retrieval from Multiband Infrared Measurements by Himawari-8",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Hironobu Iwabuchi",
                "org": "Center for Atmospheric and Oceanic Studies, Graduate School of Science, Tohoku University, Sendai, Japan"
            },
            {
                "name": "Nurfiena Sagita Putri",
                "org": "Center for Atmospheric and Oceanic Studies, Graduate School of Science, Tohoku University, Sendai, Japan"
            },
            {
                "name": "Masanori Saito",
                "org": "Center for Atmospheric and Oceanic Studies, Graduate School of Science, Tohoku University, Sendai, Japan"
            },
            {
                "name": "Yuka Tokoro",
                "org": "Center for Atmospheric and Oceanic Studies, Graduate School of Science, Tohoku University, Sendai, Japan"
            },
            {
                "name": "Miho Sekiguchi",
                "org": "The Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Tokyo, Japan"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University,  Texas, USA"
            },
            {
                "name": "Bryan A. Baum",
                "org": ""
            }
        ],
        "venue": "Journal of The Meteorological Society of Japan",
        "year": 2018
    },
    "J5GOQVBf": {
        "id": "J5GOQVBf",
        "title": "Role of stabilized Criegee Intermediates in the formation of atmospheric sulfate in eastern United States",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jingyi li",
                "org": ""
            },
            {
                "name": "qi ying",
                "org": ""
            },
            {
                "name": "bingqi yi",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            }
        ],
        "venue": "Atmospheric Environment",
        "year": 2013
    },
    "h7gpEmYm": {
        "id": "h7gpEmYm",
        "title": "Cirrus feedback on interannual climate fluctuations: Cirrus feedback on climate fluctuations",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "a e dessler",
                "org": ""
            },
            {
                "name": "mark d zelinka",
                "org": ""
            },
            {
                "name": "tong wang",
                "org": ""
            },
            {
                "name": "p yang",
                "org": ""
            },
            {
                "name": "chaowei zhou",
                "org": ""
            }
        ],
        "venue": "Geophysical Research Letters",
        "year": 2014
    },
    "CHXYSLeo": {
        "id": "CHXYSLeo",
        "title": "Using depolarization to quantify ice nucleating particle concentrations: a new method",
        "abstract": "We have developed a new method to determine ice nucleating particle (INP) concentrations observed by a Continuous Flow Diffusion Chamber (CFDC) under a wide range of operating conditions. In this study, we evaluate differences in particle optical properties detected by the Cloud and Aerosol Spectrometer with POLarization (CASPOL) to differentiate between ice crystals, droplets, and aerosols. The depolarization signal from the CASPOL instrument is used to determine the occurrence of water droplet breakthrough (WDBT) conditions in the CFDC, under which traditional determination of ice nucleating particle concentrations by size discrimination fails. To overcome the challenge of WDBT, we design a new analysis method using depolarization ratio that can extend the range of operating conditions of the CFDC. The method agrees reasonably well with the traditional method under non-WDBT conditions with a mean percent error of \u00b132.1\u2009%. Additionally, a comparison with the Colorado State University (CSU) CFDC shows that the new analysis method can be used reliably during WDBT conditions.",
        "keywords": "",
        "authors": [
            {
                "name": "Jake Zenker",
                "org": "Department of Atmospheric  Science, Texas A&M University, College Station, TX 77843"
            },
            {
                "name": "Kristen N. Collier",
                "org": "Department of Atmospheric  Science, Texas A&M University, College Station, TX 77843"
            },
            {
                "name": "Guanglang Xu",
                "org": "Department of Atmospheric  Science, Texas A&M University, College Station, TX 77843"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric  Science, Texas A&M University, College Station, TX 77843"
            },
            {
                "name": "E. J. T. Levin",
                "org": "Department of Atmospheric Science, Colorado State University, Fort Collins, CO 80526"
            },
            {
                "name": "Kaitlyn J. Suski",
                "org": "Department of Atmospheric Science, Colorado State University, Fort Collins, CO 80526"
            },
            {
                "name": "Kaitlyn J. Suski",
                "org": "Department of Atmospheric Science, Colorado State University, Fort Collins, CO 80526"
            },
            {
                "name": "Paul J. DeMott",
                "org": "Department of Atmospheric Science, Colorado State University, Fort Collins, CO 80526"
            },
            {
                "name": "Sarah D. Brooks",
                "org": "Department of Atmospheric  Science, Texas A&M University, College Station, TX 77843"
            }
        ],
        "venue": "Atmospheric Measurement Techniques",
        "year": 2017
    },
    "xO13nbrZ": {
        "id": "xO13nbrZ",
        "title": "A new parameterization of single-scattering radiative properties for tropical ice clouds using observed ice crystal size and shape distributions",
        "abstract": "",
        "keywords": [
            "cross section",
            "ray tracing",
            "monte carlo",
            "general circulation model",
            "chebyshev polynomial",
            "neural network",
            "self organization",
            "statistical significance",
            "single crystal"
        ],
        "authors": [
            {
                "name": "greg m mcfarquhar",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "andreas macke",
                "org": ""
            },
            {
                "name": "j baran",
                "org": ""
            }
        ],
        "venue": "Journal of the Atmospheric Sciences",
        "year": 2001
    },
    "FiECBmDt": {
        "id": "FiECBmDt",
        "title": "Degree of ice particle surface roughness inferred from polarimetric observations",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "souichiro hioki",
                "org": "texas a m university"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "bryan a baum",
                "org": "university of wisconsin madison"
            },
            {
                "name": "steven platnick",
                "org": "goddard space flight center"
            },
            {
                "name": "kerry meyer",
                "org": "universities space research association"
            },
            {
                "name": "michael d king",
                "org": "university of colorado boulder"
            },
            {
                "name": "jerome riedi",
                "org": "lille university of science and technology"
            }
        ],
        "venue": "Atmospheric Chemistry and Physics",
        "year": 2015
    },
    "M7DiSodZ": {
        "id": "M7DiSodZ",
        "title": "Influence of Ice Particle Surface Roughening on the Global Cloud Radiative Effect",
        "abstract": "",
        "keywords": [
            "climate models",
            "radiative forcing",
            "parameterization",
            "surface roughness",
            "crystals",
            "diameters",
            "light scattering",
            "cloud forcing",
            "simulation",
            "ice crystals",
            "atmospheric models",
            "radiative transfer"
        ],
        "authors": [
            {
                "name": "bingqi yi",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "bryan a baum",
                "org": ""
            },
            {
                "name": "tristan s lecuyer",
                "org": ""
            },
            {
                "name": "lazaros oreopoulos",
                "org": ""
            },
            {
                "name": "eli j mlawer",
                "org": ""
            },
            {
                "name": "andrew j heymsfield",
                "org": ""
            },
            {
                "name": "kuonan liou",
                "org": ""
            }
        ],
        "venue": "Journal of the Atmospheric Sciences",
        "year": 2013
    },
    "7msswg3M": {
        "id": "7msswg3M",
        "title": "Stochastic parameterization for light absorption by internally mixed BC/dust in snow grains for application to climate models: ABSORPTION BY BC IN SNOW",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "w l lee",
                "org": ""
            },
            {
                "name": "yu gu",
                "org": ""
            },
            {
                "name": "k n liou",
                "org": ""
            },
            {
                "name": "y takano",
                "org": ""
            },
            {
                "name": "chengwei he",
                "org": ""
            },
            {
                "name": "peter yang",
                "org": ""
            },
            {
                "name": "l r leung",
                "org": ""
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2014
    },
    "0gxO2Mhc": {
        "id": "0gxO2Mhc",
        "title": "Sensitivity of Cirrus Bidirectional Reflectance at MODIS Bands to Vertical Inhomogeneity of Ice Crystal Habits and Size Distribution",
        "abstract": "",
        "keywords": [
            "radiative transfer",
            "spectral reflectance",
            "sensitivity",
            "climatology",
            "algorithms",
            "light scattering",
            "crystals"
        ],
        "authors": [
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "b c gao",
                "org": ""
            },
            {
                "name": "bryan a baum",
                "org": ""
            },
            {
                "name": "warren j wiscombe",
                "org": ""
            },
            {
                "name": "yongxiang hu",
                "org": ""
            },
            {
                "name": "shaima l nasiri",
                "org": ""
            },
            {
                "name": "peter f soulen",
                "org": ""
            },
            {
                "name": "andrew j heymsfield",
                "org": ""
            },
            {
                "name": "greg m mcfarquhar",
                "org": ""
            },
            {
                "name": "larry m miloshevich",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2000
    },
    "ATHV93Xq": {
        "id": "ATHV93Xq",
        "title": "Radiative and Microphysical Properties of Cirrus Cloud Inferred from Infrared Measurements Made by the Moderate Resolution Imaging Spectroradiometer (MODIS). Part I: Retrieval Method",
        "abstract": "",
        "keywords": [
            "ice crystals",
            "infrared radiation"
        ],
        "authors": [
            {
                "name": "hironobu iwabuchi",
                "org": ""
            },
            {
                "name": "soichiro yamada",
                "org": ""
            },
            {
                "name": "shuichiro katagiri",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "hajime okamoto",
                "org": ""
            }
        ],
        "venue": "Journal of Applied Meteorology and Climatology",
        "year": 2014
    },
    "dWqGmoyp": {
        "id": "dWqGmoyp",
        "title": "Cloudy sounding and cloud-top height retrieval from AIRS alone single field-of-view radiance measurements",
        "abstract": "High-spectral resolution measurements from the Atmospheric Infrared Sounder (AIRS) onboard the EOS (Earth Observing System) Aqua satellite provide unique information about atmospheric state, surface and cloud properties. This paper presents an AIRS alone single field-of-view (SFOV) retrieval algorithm to simultaneously retrieve temperature, humidity and ozone profiles under all weather conditions, as well as cloud-top pressure (CTP) under cloudy skies. For optically thick cloud conditions the above-cloud soundings are derived, whereas for clear skies and optically thin cloud conditions the profiles are retrieved from 0.005 hPa down to the earth's surface. Initial validation has been conducted by using the operational MODIS (Moderate Resolution Imaging Spectroradiometer) product, ECMWF (European Centre for Medium-Range Weather Forecasts) analysis fields and radiosonde observations (RAOBs). These inter-comparisons clearly demonstrate the potential of this algorithm to process data from high-spectral infrared (IR) sounder instruments.",
        "keywords": [
            "cloudy sounding",
            "cloud-top pressure",
            "hyperspectral",
            "optical thickness",
            "high resolution",
            "ozone",
            "field of view",
            "remote sensing",
            "data processing",
            "infrared",
            "spectral resolution",
            "weather forecasting"
        ],
        "authors": [
            {
                "name": "Elisabeth Weisz",
                "org": ""
            },
            {
                "name": "Jun Li",
                "org": ""
            },
            {
                "name": "Jinlong Li",
                "org": ""
            },
            {
                "name": "Daniel K. Zhou",
                "org": ""
            },
            {
                "name": "Hung-Lung Huang",
                "org": ""
            },
            {
                "name": "Mitchell D. Goldberg",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            }
        ],
        "venue": "Geophysical Research Letters",
        "year": 2007
    },
    "rZ07Exqg": {
        "id": "rZ07Exqg",
        "title": "CERES Edition-2 Cloud Property Retrievals Using TRMM VIRS and Terra and Aqua MODIS Data - Part I: Algorithms.",
        "abstract": "",
        "keywords": [
            "free surface",
            "particle size",
            "near infrared",
            "snow",
            "remote sensing",
            "imaging spectrometer",
            "infrared",
            "calibration",
            "data analysis"
        ],
        "authors": [
            {
                "name": "Patrick Minnis",
                "org": ""
            },
            {
                "name": "Szedung Sun-Mack",
                "org": ""
            },
            {
                "name": "David F. Young",
                "org": ""
            },
            {
                "name": "Patrick W. Heck",
                "org": ""
            },
            {
                "name": "Donald P. Garber",
                "org": ""
            },
            {
                "name": "Yan Chen",
                "org": ""
            },
            {
                "name": "Douglas A. Spangenberg",
                "org": ""
            },
            {
                "name": "Robert F. Arduini",
                "org": ""
            },
            {
                "name": "Qing Z. Trepte",
                "org": ""
            },
            {
                "name": "William L. Smith",
                "org": ""
            },
            {
                "name": "Kirk Ayers",
                "org": ""
            },
            {
                "name": "Sharon Gibson",
                "org": ""
            },
            {
                "name": "Walter F. Miller",
                "org": ""
            },
            {
                "name": "Gang Hong",
                "org": ""
            },
            {
                "name": "Venkatesan Chakrapani",
                "org": ""
            },
            {
                "name": "Yoshihide Takano",
                "org": ""
            },
            {
                "name": "Kuo-Nan Liou",
                "org": ""
            },
            {
                "name": "Yu Xie",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            }
        ],
        "venue": "IEEE T. Geoscience and Remote Sensing",
        "year": 2011
    },
    "HaufdRBD": {
        "id": "HaufdRBD",
        "title": "Application of a discontinuous Galerkin time domain method to simulation of optical properties of dielectric particles.",
        "abstract": "We applied a discontinuous Galerkin time domain (DGTD) method, using a fourth-order Runga-Kutta time stepping of the Maxwell equations, to the simulation of the optical properties of dielectric particles in two-dimensional (2D) geometry. As examples of the numerical implementation of this method, the single-scattering properties of 2D circular and hexagonal particles are presented. In the case of circular particles, the scattering phase matrix was computed using the DGTD method and compared with the exact solution. For hexagonal particles, the DGTD method was used to compute single-scattering properties of randomly oriented 2D hexagonal ice crystals, and results were compared with those calculated using a geometric optics method. We consider both shortwave (visible) and longwave (infrared) cases, with particle size parameters 50 and 100. In the hexagonal case, scattering results are also presented as a function of both incident and scattering angles, revealing a structure apparently not reported before. Using the geometric optics method, we are able to interpret this structure in terms of contributions from varying numbers of internal reflections within the crystal.",
        "keywords": [
            "maxwell equation",
            "geometric optics",
            "particle size",
            "physical optics",
            "infrared",
            "exact solution",
            "scattering"
        ],
        "authors": [
            {
                "name": "Guanglin Tang",
                "org": "Department of Atmospheric Sciences|Texas A&M University"
            },
            {
                "name": "R Lee Panetta",
                "org": "Department of Atmospheric Sciences|Texas A&M University"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences|Texas A&M University"
            }
        ],
        "venue": "Applied optics",
        "year": 2010
    },
    "Ye4VewTf": {
        "id": "Ye4VewTf",
        "title": "CALIPSO/CALIOP Cloud Phase Discrimination Algorithm",
        "abstract": "",
        "keywords": [
            "algorithms"
        ],
        "authors": [
            {
                "name": "Yongxiang Hu",
                "org": ""
            },
            {
                "name": "David Winker",
                "org": ""
            },
            {
                "name": "Mark Vaughan",
                "org": ""
            },
            {
                "name": "Bing Lin",
                "org": ""
            },
            {
                "name": "Ali Omar",
                "org": ""
            },
            {
                "name": "Charles Trepte",
                "org": ""
            },
            {
                "name": "David Flittner",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Shaima L. Nasiri",
                "org": ""
            },
            {
                "name": "Bryan Baum",
                "org": ""
            },
            {
                "name": "Wenbo Sun",
                "org": ""
            },
            {
                "name": "Zhaoyan Liu",
                "org": ""
            },
            {
                "name": "Zhien Wang",
                "org": ""
            },
            {
                "name": "Stuart Young",
                "org": ""
            },
            {
                "name": "Knut Stamnes",
                "org": ""
            },
            {
                "name": "Jianping Huang",
                "org": ""
            },
            {
                "name": "Ralph Kuehn",
                "org": ""
            },
            {
                "name": "Robert Holz",
                "org": ""
            }
        ],
        "venue": "Journal of Atmospheric and Oceanic Technology",
        "year": 2009
    },
    "bjpiYoHZ": {
        "id": "bjpiYoHZ",
        "title": "A fast Visible Infrared Imaging Radiometer Suite simulator for cloudy atmospheres: Fast Radiometric Observation Simulator",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shouguo ding",
                "org": ""
            },
            {
                "name": "chenxi wang",
                "org": ""
            },
            {
                "name": "kerry meyer",
                "org": ""
            },
            {
                "name": "steven platnick",
                "org": ""
            },
            {
                "name": "s l nasiri",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "chao liu",
                "org": ""
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2015
    },
    "W67Y9mkA": {
        "id": "W67Y9mkA",
        "title": "Asymptotic solutions for optical properties of large particles with strong absorption.",
        "abstract": "The transverse wave condition is not applicable to the refracted electromagnetic wave within the context of geometrical optics when absorption is involved. Either the TM or the TE wave condition can be assumed for the wave to locally satisfy the electromagnetic boundary condition in a ray-tracing calculation. The assumed wave mode affects both the reflection and the refraction coefficients. As a result, nonunique solutions for these coefficients are inevitable. In this study the appropriate solutions for the Fresnel reflection-refraction coefficients are identified in light-scattering calculations based on the ray-tracing technique. In particular, a 3 x 2 refraction or transmission matrix is derived to account for the inhomogeneity of the refracted wave in an absorbing medium. An asymptotic solution that completely includes the effect of medium absorption on Fresnel coefficients is obtained for the scattering properties of a general polyhedral particle. Numerical results are presented for hexagonal plates and columns with both preferred and random orientations.",
        "keywords": [
            "asymptotic series",
            "boundary condition",
            "albedo",
            "geometrical optics",
            "geometric optics",
            "coefficients",
            "satisfiability",
            "electromagnetic waves",
            "refraction",
            "boundary conditions",
            "meteorology",
            "transverse waves",
            "reflectance",
            "numerical analysis",
            "light scattering",
            "fresnel diffraction",
            "ray tracing",
            "atmospheric optics",
            "atmospheric scattering"
        ],
        "authors": [
            {
                "name": "P Yang",
                "org": ""
            },
            {
                "name": "B C Gao",
                "org": ""
            },
            {
                "name": "B A Baum",
                "org": ""
            },
            {
                "name": "Y X Hu",
                "org": ""
            },
            {
                "name": "W J Wiscombe",
                "org": ""
            },
            {
                "name": "M I Mishchenko",
                "org": ""
            },
            {
                "name": "D M Winker",
                "org": ""
            },
            {
                "name": "S L Nasiri",
                "org": ""
            }
        ],
        "venue": "Applied optics",
        "year": 2001
    },
    "jepJriQg": {
        "id": "jepJriQg",
        "title": "Sensitivity of cirrus bidirectional reflectance to vertical inhomogeneity of ice crystal habits and size distributions for two Moderate-Resolution Imaging Spectroradiometer (MODIS) bands",
        "abstract": "",
        "keywords": [
            "light scattering",
            "radiative transfer",
            "particle size distribution",
            "international satellite cloud climatology project",
            "remote sensing"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Bo-Cai Gao",
                "org": ""
            },
            {
                "name": "Bryan A. Baum",
                "org": ""
            },
            {
                "name": "Warren J. Wiscombe",
                "org": ""
            },
            {
                "name": "Yong X. Hu",
                "org": ""
            },
            {
                "name": "Shaima L. Nasiri",
                "org": ""
            },
            {
                "name": "Peter F. Soulen",
                "org": ""
            },
            {
                "name": "Andrew J. Heymsfield",
                "org": ""
            },
            {
                "name": "Greg M. McFarquhar",
                "org": ""
            },
            {
                "name": "Larry M. Miloshevich",
                "org": ""
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2001
    },
    "6HjRluPr": {
        "id": "6HjRluPr",
        "title": "Development of a GOES-R Advanced Baseline Imager Solar Channel Radiance Simulator for Ice Clouds",
        "abstract": "",
        "keywords": [
            "ice crystals"
        ],
        "authors": [
            {
                "name": "shouguo ding",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "bryan a baum",
                "org": ""
            },
            {
                "name": "andrew k heidinger",
                "org": ""
            },
            {
                "name": "thomas j greenwald",
                "org": ""
            }
        ],
        "venue": "Journal of Applied Meteorology and Climatology",
        "year": 2013
    },
    "bfLVKGRH": {
        "id": "bfLVKGRH",
        "title": "Improvements in Shortwave Bulk Scattering and Absorption Models for the Remote Sensing of Ice Clouds",
        "abstract": "",
        "keywords": [
            "remote sensing",
            "absorption",
            "ice crystals"
        ],
        "authors": [
            {
                "name": "bryan a baum",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "andrew j heymsfield",
                "org": ""
            },
            {
                "name": "carl schmitt",
                "org": ""
            },
            {
                "name": "yu xie",
                "org": ""
            },
            {
                "name": "aaron bansemer",
                "org": ""
            },
            {
                "name": "yongxiang hu",
                "org": ""
            },
            {
                "name": "zhibo zhang",
                "org": ""
            }
        ],
        "venue": "Journal of Applied Meteorology and Climatology",
        "year": 2011
    },
    "01cEUI4e": {
        "id": "01cEUI4e",
        "title": "Determination of Ice Cloud Models Using MODIS and MISR Data",
        "abstract": "",
        "keywords": [
            "aspect ratio",
            "geometric optics",
            "radiative transfer",
            "particle size",
            "algorithms",
            "remote sensing",
            "data acquisition",
            "simulation",
            "measurement uncertainty",
            "sensitivity",
            "root mean square",
            "optical thickness",
            "atmospheric models"
        ],
        "authors": [
            {
                "name": "yu xie",
                "org": "texas a m university"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "george w kattawar",
                "org": "texas a m university"
            },
            {
                "name": "patrick minnis",
                "org": "langley research center"
            },
            {
                "name": "yongxiang hu",
                "org": "langley research center"
            },
            {
                "name": "d l wu",
                "org": "jet propulsion laboratory"
            }
        ],
        "venue": "International Journal of Remote Sensing",
        "year": 2012
    },
    "i2AtfbPo": {
        "id": "i2AtfbPo",
        "title": "Snow optical properties for different particle shapes with application to snow grain size retrieval and MODIS/CERES radiance comparison over Antarctica",
        "abstract": "We investigated the single scattering optical properties of snow for different ice particle shapes and degrees of microscopic scale roughness. These optical properties were implemented and tested in a coupled atmosphere-snow radiative transfer model. The modeled surface spectral albedo and radiance distribution were compared with surface measurements. The results show that the reflected radiance and irradiance over snow are sensitive to the snow grain size and its vertical profile. When inhomogeneity of the particle size distribution in the vertical is taken into account, the measured spectral albedo can be matched, regardless of the particle shapes. But this is not true for the modeled radiance distribution, which depends a lot on the particle shape. The usual \u201cequivalent spheres\u201d assumption significantly overestimates forward reflected radiances, and underestimates backscattering radiances, around the principal plane. On average, the aggregate shape assumption has the best agreement with the measured radiances to a mean bias within 2%. The snow optical properties with the aggregate assumption were applied to the retrieval of snow grain size over the Antarctic plateau. The retrieved grain sizes of the top layer showed similar and large seasonal variation in all years, but only small year to year variation. Using the retrieved snow grain sizes, the modeled spectral and broadband radiances showed good agreements with MODIS and CERES measurements over the Antarctic plateau. Except for the MODIS 2.13\u00a0\u03bcm channel, the mean relative model-observation differences are within few percent. The modeled MODIS radiances using measured surface reflectance at Dome C also showed good agreement in visible channels, where radiation is not sensitive to snow grain size and the measured surface bidirectional reflectance is applicable over the Antarctic plateau. But modeled radiances using local, surface-measured reflectance in the near infrared yielded large errors because of the high sensitivity to the snow grain size, which varies spatially and temporally. The CERES broadband shortwave radiance is moderately sensitive to the snow grain size, comparable to the MODIS 0.86\u00a0\u03bcm channel. The variation of broadband snow reflectance due to the seasonal variation in snow grain size is about 5% in a year over the Antarctic plateau. CERES broadband radiances simulated with grain sizes retrieved using MODIS are about 2% larger than those observed.",
        "keywords": [
            "snow grain size retrieval",
            "radiance",
            "snow",
            "radiative transfer",
            "grain size",
            "near infrared",
            "radiative transfer model",
            "seasonal variation",
            "particle size distribution"
        ],
        "authors": [
            {
                "name": "Zhonghai Jin",
                "org": ""
            },
            {
                "name": "Thomas P. Charlock",
                "org": "Mail Stop 420, Climate Science Branch, Science Directorate, NASA Langley Research Center, Hampton, Virginia 23681-2199, United States"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, United States"
            },
            {
                "name": "Yu Xie",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, United States"
            },
            {
                "name": "Walter Miller",
                "org": "Science Systems and Applications, Inc., One Enterprise PKWY, STE 200, Hampton, VA 23666, United States"
            }
        ],
        "venue": "Remote Sensing of Environment",
        "year": 2008
    },
    "hDIdjJfK": {
        "id": "hDIdjJfK",
        "title": "Cirrus feedback on interannual climate fluctuations",
        "abstract": "",
        "keywords": [
            "cloud feedback"
        ],
        "authors": [
            {
                "name": "c zhou",
                "org": "lawrence livermore national laboratory"
            },
            {
                "name": "a e dessler",
                "org": "texas a m university"
            },
            {
                "name": "mark d zelinka",
                "org": "lawrence livermore national laboratory"
            },
            {
                "name": "p yang",
                "org": "texas a m university"
            },
            {
                "name": "tong wang",
                "org": "california institute of technology"
            }
        ],
        "venue": "Geophysical Research Letters",
        "year": 2014
    },
    "91fPhjze": {
        "id": "91fPhjze",
        "title": "Ice particle morphology and microphysical properties of cirrus clouds inferred from combined CALIOP-IIR measurements: ICE CRYSTALS IN CIRRUS CLOUDS",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Masanori Saito",
                "org": "Department of Geophysics, Graduate School of Science; Tohoku University; Sendai Japan"
            },
            {
                "name": "Hironobu Iwabuchi",
                "org": "Department of Geophysics, Graduate School of Science; Tohoku University; Sendai Japan"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences; Texas A&M University; College Station Texas USA"
            },
            {
                "name": "Guanglin Tang",
                "org": "Department of Atmospheric Sciences; Texas A&M University; College Station Texas USA"
            },
            {
                "name": "Michael D. King",
                "org": "Department of Atmospheric Sciences; Texas A&M University; College Station Texas USA"
            },
            {
                "name": "Michael D. King",
                "org": "Department of Atmospheric Sciences; Texas A&M University; College Station Texas USA"
            },
            {
                "name": "Miho Sekiguchi",
                "org": "Department of Marine Electronics and Mechanical Engineering; Tokyo University of Marine Science and Technology; Tokyo Japan"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2017
    },
    "1KASxCjF": {
        "id": "1KASxCjF",
        "title": "Depolarization ratio and attenuated backscatter for nine cloud types: analyses based on collocated CALIPSO lidar and MODIS measurements.",
        "abstract": "This paper reports on the relationship between lidar backscatter and the corresponding depolarization ratio for nine types of cloud systems. The data used in this study are the lidar returns measured by the Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP) aboard the Cloud- Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO) satellite and the collocated cloud products derived from the observations made by the Moderate Resolution Imaging Spectroradiometer (MODIS) aboard Aqua satellite. Specifically, the operational MODIS cloud optical thickness and cloud-top pressure products are used to classify cloud types on the basis of the International Satellite Cloud Climatology Project (ISCCP) cloud classification scheme. While the CALIPSO observations provide information for up to 10 cloud layers, in the present study only the uppermost clouds are considered. The layer-averaged attenuated backscatter (gamma') and layer-averaged depolarization ratio (delta) from the CALIPSO measurements show both water- and ice-phase features for global cirrus, cirrostratus, and deep convective cloud classes. Furthermore, we screen both the MODIS and CALIPSO data to eliminate cases in which CALIPSO detected two- or multi-layered clouds. It is shown that low gamma' values corresponding to uppermost thin clouds are largely eliminated in the CALIPSO delta-gamma' relationship for single-layered clouds. For mid-latitude and polar regions corresponding, respectively, to latitude belts 30 degrees -60 degrees and 60 degrees -90 degrees in both the hemispheres, a mixture of water and ice is also observed in the case of the altostratus class. MODIS cloud phase flags are also used to screen ice clouds. The resultant water clouds flagged by the MODIS algorithm show only water phase feature in the delta-gamma' relation observed by CALIOP; however, in the case of the ice clouds flagged by the MODIS algorithm, the co-existence of ice- and water-phase clouds is still observed in the CALIPSO delta-gamma' relationship.",
        "keywords": [],
        "authors": [
            {
                "name": "Hyoun-Myoung Cho",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "George W Kattawar",
                "org": ""
            },
            {
                "name": "Shaima L Nasiri",
                "org": ""
            },
            {
                "name": "Yongxiang Hu",
                "org": ""
            },
            {
                "name": "Patrick Minnis",
                "org": ""
            },
            {
                "name": "Charles Trepte",
                "org": ""
            },
            {
                "name": "David Winker",
                "org": ""
            }
        ],
        "venue": "Optics express",
        "year": 2008
    },
    "tCBcBTnG": {
        "id": "tCBcBTnG",
        "title": "Toward an Observation-Based Estimate of Dust Net Radiative Effects in Tropical North Atlantic Through Integrating Satellite Observations and In SituMeasurements of Dust Properties",
        "abstract": "In this study, we integrate recent aircraft measurements of dust microphysical and optical properties with satellite retrievals of aerosol and radiative fluxes to quantify the dust direct radiative effects on the shortwave (SW) and longwave (LW) radiation (denoted as DRESW and DRELW, respectively) at both the top of atmosphere (TOA) and surface in the tropical North Atlantic during summer months. Through linear regression of CERES measured TOA flux versus satellite aerosol optical depth (AOD) retrievals under cloud-free and dust-laden atmospheric conditions, we estimate the instantaneous DRESW efficiency at the top of the atmosphere (TOA) to be \u201349.7\u00b17.1\u2009W/m 2 /AOD and \u201336.5\u00b14.8\u2009W/m 2 /AOD based on AOD from MODIS and CALIOP, respectively. The corresponding DRESW at TOA is \u201314.2\u00b12.0\u2009W/m 2  and \u201310.4\u00b11.4\u2009W/m 2 , respectively. We also estimate the instantaneous DRELW at TOA to be between +2.7\u00b10.32\u2009W/m 2  to +3.4\u00b10.32\u2009W/m 2  based on the difference between computed dust-free outgoing longwave radiation (OLR) and CERES-measured OLR. We then perform various sensitivity studies with recent measurements of dust particle size distribution (PSD), refractive index, and particle shape distribution to determine how the dust microphysical and optical properties affect DRE estimates and its agreement with abovementioned satellite-derived DREs. Our analysis shows that a good agreement with the observation-based estimates of instantaneous DRESW and DRELW can be achieved through a combination of recently observed PSD with substantial presence of coarse particles, a less absorptive SW refractive index, and spheroid shapes. Based on this optimal combination of dust physical and optical properties we further estimate the diurnal mean dust DRESW efficiency of \u201328\u2009W/m 2 /AOD at TOA and \u201382\u2009W/m 2 /AOD at surface. The corresponding TOA and surface DRESW in the region is approximately \u201310\u2009W/m 2  and \u201326\u2009W/m 2 , respectively, of which ~30% is canceled out by the positive DRELW. This yields a net DRE of about \u20136.9\u2009W/m 2  and \u201318.3\u2009W/m 2  at TOA and surface, respectively. Our study suggests that the LW flux contains useful information of dust particle size, which could be used together with SW observation to achieve more holistic understanding of the dust radiative effect.",
        "keywords": "",
        "authors": [
            {
                "name": "Qianqian Song",
                "org": "Physics Department, University of Maryland Baltimore County"
            },
            {
                "name": "Zhibo Zhang",
                "org": "Physics Department, University of Maryland Baltimore County"
            },
            {
                "name": "Hongbin Yu",
                "org": "NASA Goddard Space Flight Center"
            },
            {
                "name": "Seiji Kato",
                "org": "NASA Langley Research Center"
            },
            {
                "name": "Ping Yang",
                "org": "Dept. of Atmospheric Sciences, Texas A&M University"
            },
            {
                "name": "Peter R. Colarco",
                "org": "NASA Goddard Space Flight Center"
            },
            {
                "name": "Lorraine A. Remer",
                "org": "Joint Center for Earth Systems  Technology, University of Maryland Baltimore County"
            },
            {
                "name": "Claire L. Ryder",
                "org": "Department of Meteorology, University of Reading,  RG6 6BB,  UK"
            }
        ],
        "venue": "Atmospheric Chemistry and Physics",
        "year": 2018
    },
    "8d83OAQH": {
        "id": "8d83OAQH",
        "title": "Inference of an Optimal Ice Particle Model through Latitudinal Analysis of MISR and MODIS Data.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yi Wang",
                "org": ""
            },
            {
                "name": "Souichiro Hioki",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Michael D. King",
                "org": ""
            },
            {
                "name": "Larry Di Girolamo",
                "org": ""
            },
            {
                "name": "Dongwei Fu",
                "org": ""
            },
            {
                "name": "Bryan A. Baum",
                "org": ""
            }
        ],
        "venue": "Remote Sensing",
        "year": 2018
    },
    "W68aUhDC": {
        "id": "W68aUhDC",
        "title": "Polarization of light in the atmosphere and ocean",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "george w kattawar",
                "org": "texas a m university"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "yu you",
                "org": "texas a m university"
            },
            {
                "name": "lei bi",
                "org": "texas a m university"
            },
            {
                "name": "yu xie",
                "org": "texas a m university"
            },
            {
                "name": "xin huang",
                "org": "texas a m university"
            },
            {
                "name": "souichiro hioki",
                "org": "texas a m university"
            }
        ],
        "venue": "",
        "year": 2016
    },
    "mrrEsAGJ": {
        "id": "mrrEsAGJ",
        "title": "Improvement of aerosol optical depth retrieval from MODIS spectral reflectance over the global ocean using new aerosol models archived from AERONET inversion data and tri-axial ellipsoidal dust database",
        "abstract": "",
        "keywords": [
            "data bases",
            "atmospheric models",
            "algorithms",
            "inversions",
            "aerosol optical depth",
            "scattering",
            "optical thickness",
            "spectral reflectance"
        ],
        "authors": [
            {
                "name": "jemin lee",
                "org": "goddard space flight center"
            },
            {
                "name": "jaehwan kim",
                "org": "university of california los angeles"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "n c hsu",
                "org": "goddard space flight center"
            }
        ],
        "venue": "Atmospheric Chemistry and Physics",
        "year": 2012
    },
    "qbnv9URX": {
        "id": "qbnv9URX",
        "title": "Radiative properties of cirrus clouds in the infrared (8\u201313 \u03bcm) spectral region",
        "abstract": "Abstract Atmospheric radiation in the infrared (IR) 8\u201313 \ufffd m,spectral region contains a wealth of information that is very useful for the retrieval of ice cloud properties from aircraft or space-borne measurements. To provide the scattering and absorption properties of nonspherical ice crystals that are fundamental to the IR retrieval implementation, we use the <nite-di=erence time-domain (FDTD) method to solve for the extinction e@ciency, single-scattering albedo, and the asymmetry parameter of the phase function for ice crystals smaller than 40 \ufffd m. For particles larger than this size, the improved geometric optics method (IGOM) can be employed to calculate the asymmetry parameter with an acceptable accuracy, provided that we properly account for the inhomogeneity of the refracted wave due to strong absorption inside the ice particle. A combination of the results computed from the two methods provides the asymmetry parameter for the entire practical range of particle sizes between 1 and 10; 000 \ufffd m over the wavelengths ranging from 8 to 13 \ufffd m. For the extinction and absorption e@ciency calculations, several methods including the IGOM, Mie solution for equivalent spheres (MSFES), and the anomalous di=raction theory (ADT) can lead to a substantial discontinuity in comparison with the FDTD solutions for particle sizes on the order of 40 \ufffd m. To overcome this di@culty, we have developed a novel approach called the stretched scattering potential method (SSPM). For the IR 8\u201313 \ufffd m spectral region, we show that SSPM is a more accurate approximation than ADT, MSFES, and IGOM. The SSPM solution can be further",
        "keywords": [],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Bo-cai Gao",
                "org": ""
            },
            {
                "name": "Bryan A. Baum",
                "org": "Remote Sensing Division, Naval Research Laboratory, Washington, DC, USA"
            },
            {
                "name": "Yong X. Hu",
                "org": "NASA Langley Research Center, Hampton, VA, USA"
            },
            {
                "name": "Warren J. Wiscombe",
                "org": "Code 913, NASA Goddard Space Flight Center, Greenbelt, MD 20771, USA"
            },
            {
                "name": "Si-chee Tsay",
                "org": ""
            },
            {
                "name": "Dave M. Winker",
                "org": "Code 913, NASA Goddard Space Flight Center, Greenbelt, MD 20771, USA"
            },
            {
                "name": "Shaima L. Nasiri",
                "org": "NASA Langley Research Center, Hampton, VA, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2001
    },
    "ry9Qk9Zf": {
        "id": "ry9Qk9Zf",
        "title": "Single-scattering properties of droxtals",
        "abstract": "Small ice crystals have been found to occur in high concentrations in polar stratospheric clouds and the upper portion of cirrus clouds, where temperatures are extremely low (often less than \u221250\u00b0C). The scattering properties of these small crystals are important to space-borne remote sensing, especially for the retrieval of cirrus properties using visible and near-infrared channels. Previous research has shown that the commonly used spherical and \u201cquasi-spherical\u201d approximations for these ice crystals can lead to significant errors in light scattering and radiative transfer calculations. We suggest that droxtals more accurately represent the shape of these small ice crystals. The single-scattering properties of ice droxtals have been computed at visible and infrared wavelengths using the finite-difference time domain method for size parameters smaller than 20. Further study of the optical properties of larger droxtals (size parameter greater than 20) will be carried out using an improved geometric optics method.",
        "keywords": [
            "optical properties",
            "small ice crystals",
            "droxtals",
            "remote sensing",
            "near infrared",
            "light scattering",
            "geometric optics",
            "radiative transfer",
            "infrared"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Bryan A Baum",
                "org": "NASA Langley Research Center, MS 420, Hampton, VA 23681, USA"
            },
            {
                "name": "Andrew J Heymsfield",
                "org": "National Center for Atmospheric Research, Boulder, CO 8030, USA"
            },
            {
                "name": "Yong X Hu",
                "org": "NASA Langley Research Center, MS 420, Hampton, VA 23681, USA"
            },
            {
                "name": "Hung-Lung Huang",
                "org": "Cooperative Institute for Meteorological Satellite Studies, University of Wisconsin\u2013Madison, 1225 W. Dayton Street, Madison, WI 53706, USA"
            },
            {
                "name": "Si-Chee Tsay",
                "org": "Code 913, NASA Goddard Space Flight Center, Greenbelt, MD 20771, USA"
            },
            {
                "name": "Steve Ackerman",
                "org": "Cooperative Institute for Meteorological Satellite Studies, University of Wisconsin\u2013Madison, 1225 W. Dayton Street, Madison, WI 53706, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy and Radiative Transfer",
        "year": 2003
    },
    "p54paZeF": {
        "id": "p54paZeF",
        "title": "Monostatic lidar/radar invisibility using coated spheres.",
        "abstract": "The Lorenz-Mie theory is revisited to explicitly include materials whose permeability is different from unity. The expansion coefficients of the scattered field are given for light scattering by both homogeneous and coated spheres. It is shown that the backscatter is exactly zero if the impedance of the spherical particles is equal to the intrinsic impedance of the surrounding medium. If spherical particles are sufficiently large, the zero backscatter can be explained as impedance matching using the asymptotic expression for the radar backscattering cross section. In the case of a coated sphere, the shell can be regarded as a cloak if the product of the thickness and the imaginary part of the refractive index of the outer shell is large.",
        "keywords": [
            "backscattering"
        ],
        "authors": [
            {
                "name": "Peng-Wang Zhai",
                "org": ""
            },
            {
                "name": "Yu You",
                "org": ""
            },
            {
                "name": "George W Kattawar",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            }
        ],
        "venue": "Optics express",
        "year": 2008
    },
    "LnsUeoTW": {
        "id": "LnsUeoTW",
        "title": "Simulation of the scattering properties of a chain-forming triangular prism oceanic diatom",
        "abstract": "Abstract   The optical properties of diatom chains in the ocean are studied based on a combination of the many-body iterative T-matrix (MBIT) method and an improved implementation of the ray-by-ray (RBR) geometric optics method. The MBIT, a numerically accurate method, is advantageous for scatterers with linear cells. In contrast to other popular geometric optics methods, the RBR, an approximate method, considers the interference of all outgoing rays. The two methods are verified in comparison with benchmark simulations. The simulation results of diatom chains in a wide size range can be obtained with either or both methods, and each can be applied to any optically soft particle, i.e., in the case when relative refractive index approaches unity.",
        "keywords": "",
        "authors": [
            {
                "name": "Bingqiang Sun",
                "org": "Department of Physics & Astronomy, Texas A&M University, College Station, TX 77843, United States"
            },
            {
                "name": "George W. Kattawar",
                "org": "Department of Physics & Astronomy, Texas A&M University, College Station, TX 77843, United States"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Physics & Astronomy, Texas A&M University, College Station, TX 77843, United States"
            },
            {
                "name": "Michael S. Twardowski",
                "org": ""
            },
            {
                "name": "James M. Sullivan",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2016
    },
    "t8NX3GOV": {
        "id": "t8NX3GOV",
        "title": "On the retrieval of ice cloud particle shapes from POLDER measurements",
        "abstract": "",
        "keywords": [
            "crystals",
            "optical thickness",
            "radiative transfer",
            "lookup table"
        ],
        "authors": [
            {
                "name": "Wenbo Sun",
                "org": ""
            },
            {
                "name": "Norman G. Loeb",
                "org": "Center for Atmospheric Sciences, Hampton University, Hampton, VA 23668, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A & M University, College Station, TX 77843, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy and Radiative Transfer",
        "year": 2006
    },
    "mkA7gcbI": {
        "id": "mkA7gcbI",
        "title": "The spectral signature of mixed-phase clouds composed of non-spherical ice crystals and spherical liquid droplets in the terrestrial window region",
        "abstract": "An outstanding problem facing the cloud modeling and remote sensing community is to improve satellite-derived cloud microphysical and macrophysical properties when a single cloud layer exists within a temperature range for which a combination of water and ice particles may be present. This is typically known as a \u201cmixed-phase\u201d cloud condition, and is prevalent when the cloud-top temperature lies between \u221240\u00b0C and 0\u00b0C. In this paper we report on a sensitivity study of the spectral signature of mixed-phase clouds in the infrared terrestrial window region (8\u2013 13 \u03bcm ). Mixed clouds are assumed to be a vertically uniform cloud layer composed of a mixture of pristine hexagonal ice crystals and spherical water droplets. Unlike the conventional approach that derives the bulk scattering properties of mixed-phase clouds by a linear weighting of the contributions of ice and water components, the bulk single-scattering properties of mixed-phase clouds are formulated on the basis of fundamental physics. With the aid of a line-by-line radiative transfer model and a discrete ordinates radiative transfer (DISORT) computational program, we investigate the high-resolution spectral signature, expressed in terms of brightness temperature, of mixed-phase clouds with various effective sizes, ice fraction ratios, and optical thicknesses. Small particles are found to have a significant impact on the infrared spectral signature of mixed-phase clouds when the size discrepancy between the ice and water particles is large. Furthermore, the simulation results show that the infrared radiative spectrum associated with cirrus clouds can be quite different from their counterparts for cirrus clouds even if a small amount of water droplets exist in the mixed-phase cloud layer.",
        "keywords": [
            "infrared",
            "mixed-phase clouds",
            "high-resolution spectral signature",
            "single-scattering parameters",
            "remote sensing",
            "spectrum",
            "radiative transfer",
            "brightness temperature",
            "effect size",
            "high resolution"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "He-Li Wei",
                "org": "Department of Atmospheric Sciences, Texas A&M University, TAMU 3150, College Station, TX 77843, USA"
            },
            {
                "name": "Bryan A Baum",
                "org": "NASA Langley Research Center, Hampton, VA 23681, USA"
            },
            {
                "name": "Hung-Lung Huang",
                "org": "Cooperative Institute for Meteorological Satellite Studies, University of Wisconsin 1225 W. Dayton Street, Madison, WI 53706, USA"
            },
            {
                "name": "Andrew J Heymsfield",
                "org": "National Center for Atmospheric Research, Boulder, CO 8030, USA"
            },
            {
                "name": "Yong X Hu",
                "org": "NASA Langley Research Center, Hampton, VA 23681, USA"
            },
            {
                "name": "Bo-Cai Gao",
                "org": "Remote Sensing Division, Naval Research Laboratory, Washington, DC 20375, USA"
            },
            {
                "name": "David D Turner",
                "org": "Cooperative Institute for Meteorological Satellite Studies, University of Wisconsin 1225 W. Dayton Street, Madison, WI 53706, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy and Radiative Transfer",
        "year": 2003
    },
    "fHdpKYiG": {
        "id": "fHdpKYiG",
        "title": "Efficient Implementation of the Invariant Imbedding T-Matrix Method and the Separation of Variables Method Applied to Large Nonspherical Inhomogeneous Particles",
        "abstract": "",
        "keywords": [
            "integral equations",
            "light scattering",
            "geometrical optics",
            "t matrix",
            "boundary conditions",
            "radii",
            "spheres"
        ],
        "authors": [
            {
                "name": "lei bi",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "george w kattawar",
                "org": ""
            },
            {
                "name": "michael i mishchenko",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2012
    },
    "Z5tEALSg": {
        "id": "Z5tEALSg",
        "title": "Impact of radiatively interactive dust aerosols in the NASA GEOS\u20105 climate model: Sensitivity to dust particle shape and refractive index",
        "abstract": "",
        "keywords": [
            "radiative forcing",
            "modeling",
            "mie scattering",
            "shapes",
            "ellipsoids",
            "refractivity",
            "radiance",
            "atmospheric models"
        ],
        "authors": [
            {
                "name": "peter richard colarco",
                "org": "goddard space flight center"
            },
            {
                "name": "e nowottnick",
                "org": "goddard space flight center"
            },
            {
                "name": "c a randles",
                "org": "goddard space flight center"
            },
            {
                "name": "bingqi yi",
                "org": "texas a m university"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "kyumyong kim",
                "org": "goddard space flight center"
            },
            {
                "name": "jamison a smith",
                "org": "university of colorado boulder"
            },
            {
                "name": "charles gaylord bardeen",
                "org": "national center for atmospheric research"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2014
    },
    "lHj23tyF": {
        "id": "lHj23tyF",
        "title": "An Analysis of the Short-Term Cloud Feedback Using MODIS Data",
        "abstract": "",
        "keywords": [
            "feedback",
            "cloud forcing"
        ],
        "authors": [
            {
                "name": "chen zhou",
                "org": ""
            },
            {
                "name": "mark d zelinka",
                "org": ""
            },
            {
                "name": "a e dessler",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            }
        ],
        "venue": "Journal of Climate",
        "year": 2013
    },
    "gqshV01E": {
        "id": "gqshV01E",
        "title": "Zero-backscatter cloak for aspherical particles using a generalized DDA formalism.",
        "abstract": "The Discrete Dipole Approximation (DDA) formalism has been generalized to materials with permeabilities mu; not equal 1 to study the scattering properties of impedance-matched aspherical particles and cloaked spheres. We have shown analytically that any impedance-matched particle with a four-fold rotational symmetry with respect to the direction of the incident radiation has the feature of zero backscatter. Moreover, an impedance-matched coat with the aforementioned symmetry property acting on an irregular dielectric particle with the same symmetry property can substantially reduce the backscatter. This leads to a substantial reduction of the signals from an object being detected by a monostatic radar/lidar system. The DDA simulation also provides accurate information about electric field distributions in the vicinity of a cloaked sphere.",
        "keywords": [
            "metamaterials",
            "backscattering"
        ],
        "authors": [
            {
                "name": "Yu You",
                "org": ""
            },
            {
                "name": "George W Kattawar",
                "org": ""
            },
            {
                "name": "Peng-Wang Zhai",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            }
        ],
        "venue": "Optics express",
        "year": 2008
    },
    "cyfYex1P": {
        "id": "cyfYex1P",
        "title": "Inherent and apparent scattering properties of coated or uncoated spheres embedded in an absorbing host medium.",
        "abstract": "The conventional Lorenz-Mie formalism is extended to the case for a coated sphere embedded in an absorbing medium. The apparent and inherent scattering cross sections of a particle, derived from the far field and near field, respectively, are different if the host medium is absorptive. The effect of absorption within the host medium on the phase-matrix elements associated with polarization depends on the dielectric properties of the scattering particle. For the specific cases of a soot particle coated with a water layer and an ice sphere containing an air bubble, the phase-matrix elements -P12/P11 and P33/P11 are unique if the shell is thin. The radiative transfer equation for a multidisperse particle system embedded within an absorbing medium is discussed. Conventional multiple-scattering computational algorithms can be applied if scaled apparent single-scattering properties are applied.",
        "keywords": [
            "electromagnetic field",
            "polarized light",
            "cross section",
            "scattering",
            "radiative transfer",
            "wave propagation",
            "dielectric properties",
            "atmospheric optics",
            "maxwell equation",
            "formalism",
            "spectroradiometers",
            "particle system",
            "meteorology",
            "albedo",
            "algorithms",
            "near field",
            "absorption",
            "atmospheric scattering",
            "spheres",
            "radiative transfer equation",
            "light scattering"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Bo-Cai Gao",
                "org": ""
            },
            {
                "name": "Warren J Wiscombe",
                "org": ""
            },
            {
                "name": "Michael I Mishchenko",
                "org": ""
            },
            {
                "name": "Steven E Platnick",
                "org": ""
            },
            {
                "name": "Hung-Lung Huang",
                "org": ""
            },
            {
                "name": "Bryan A Baum",
                "org": ""
            },
            {
                "name": "Yong X Hu",
                "org": ""
            },
            {
                "name": "Dave M Winker",
                "org": ""
            },
            {
                "name": "Si-Chee Tsay",
                "org": ""
            },
            {
                "name": "Seon K Park",
                "org": ""
            }
        ],
        "venue": "Applied optics",
        "year": 2002
    },
    "p0KdP9lj": {
        "id": "p0KdP9lj",
        "title": "Simulation of light scattering by a pressure deformed red blood cell with a parallel FDTD method",
        "abstract": "",
        "keywords": [
            "scattering",
            "absorption",
            "parallel computer",
            "numerical simulation",
            "scattering matrix",
            "parallel computing",
            "matrices",
            "elastic scattering",
            "modeling",
            "blood flow",
            "finite difference time domain",
            "analytic solution",
            "medical diagnostics",
            "near infrared",
            "light scattering",
            "dielectric constant"
        ],
        "authors": [
            {
                "name": "r brock",
                "org": "east carolina university"
            },
            {
                "name": "xinhua hu",
                "org": "east carolina university"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "jun q lu",
                "org": "east carolina university"
            }
        ],
        "venue": "",
        "year": 2005
    },
    "RYZ5gu67": {
        "id": "RYZ5gu67",
        "title": "Considering polarization in MODIS-based cloud property retrievals by using a vector radiative transfer code",
        "abstract": "",
        "keywords": [
            "polarization"
        ],
        "authors": [
            {
                "name": "bingqi yi",
                "org": ""
            },
            {
                "name": "xin huang",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "bryan a baum",
                "org": ""
            },
            {
                "name": "george w kattawar",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2014
    },
    "N2WVqzxB": {
        "id": "N2WVqzxB",
        "title": "Effect of the inhomogeneity of ice crystals on retrieving ice cloud optical thickness and effective particle size",
        "abstract": "Received 29 September 2008; revised 16 March 2009; accepted 14 April 2009; published 5 June 2009. (1) Spherical or spheroidal air bubbles are often trapped in rapidly growing ice crystals. In this study, the single-scattering properties of inhomogeneous ice crystals containing air bubbles are investigated. Specifically, a combination of the ray-tracing technique and the Monte Carlo method is used to simulate the scattering of light by randomly oriented large hexagonal ice crystals containing spherical or spheroidal air bubbles. The effect of the air bubbles within ice crystals is to smooth the phase functions, diminish the 22 and 46 halo peaks, and reduce the backscatter in comparison with the case of bubble-free ice crystals. These features vary with the number, sizes, locations, and shapes of the air bubbles within the ice crystals. Moreover, the asymmetry factors of inhomogeneous ice crystals decrease as the ratio of air-bubble volume to ice crystal volume increases. Cloud reflectance look-up tables were generated at the wavelengths of 0.65 mm and 2.13 mm to examine the impact of accounting for air bubbles in ice crystal morphology on the retrieval of ice cloud optical thickness and effective particle size. The reflectances simulated for inhomogeneous ice crystals are larger than those computed for homogeneous ice crystals at a wavelength of 0.65 mm. Thus the retrieved cloud optical thickness is reduced by employing inhomogeneous ice cloud models. At a wavelength of 2.13 mm, including air bubbles in ice crystal morphology may also increase the reflectance. This effect implies, particularly in the case of large air bubbles, that the retrieved effective particle size for inhomogeneous ice crystals is larger than that retrieved for homogeneous ice crystals.",
        "keywords": [
            "ice crystal",
            "inhomogeneity",
            "optical thickness",
            "monte carlo method",
            "ray tracing",
            "shapes",
            "reflectance",
            "particle size",
            "scattering",
            "asymmetry",
            "crystals",
            "remote sensing",
            "look up table",
            "geometrical optics",
            "light scattering"
        ],
        "authors": [
            {
                "name": "Yu Xie",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "George W. Kattawar",
                "org": ""
            },
            {
                "name": "Patrick Minnis",
                "org": ""
            },
            {
                "name": "Yong X. Hu",
                "org": "NASA Langley Research Center"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2009
    },
    "IFY69SxT": {
        "id": "IFY69SxT",
        "title": "Remote sensing of ice crystal asymmetry parameter using multi-directional polarization measurements \u2013 Part 1: Methodology and evaluation with simulated measurements",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "b van diedenhoven",
                "org": "goddard space flight center"
            },
            {
                "name": "brian cairns",
                "org": "goddard space flight center"
            },
            {
                "name": "igor v geogdzhayev",
                "org": "columbia university"
            },
            {
                "name": "ann m fridlind",
                "org": "goddard space flight center"
            },
            {
                "name": "andrew s ackerman",
                "org": "goddard space flight center"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "bryan a baum",
                "org": "university of wisconsin madison"
            }
        ],
        "venue": "Atmospheric Measurement Techniques",
        "year": 2012
    },
    "eac8usGm": {
        "id": "eac8usGm",
        "title": "Scattering and absorption of light by ice particles: Solution by a new physical-geometric optics hybrid method",
        "abstract": "Highlights \u25ba A new physical-geometric optics hybrid (PGOH) method is developed. \u25ba The method allows studying the scattering of light by oriented ice particles. \u25ba The method allows complex refractive indices and size parameters larger than \u223c20. \u25ba The method includes edge effects for the extinction and absorption efficiencies.",
        "keywords": [
            "geometric optics",
            "hexagonal ice crystal",
            "physical optics",
            "light scattering",
            "near field",
            "discrete dipole approximation",
            "cross section",
            "particle size",
            "edge effect",
            "integral equation",
            "electric field",
            "new physics"
        ],
        "authors": [
            {
                "name": "Lei Bi",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "George W. Kattawar",
                "org": "Department of Physics and Astronomy, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Yongxiang Hu",
                "org": "Climate Science Branch, NASA Langley Research Center, Hampton, VA 23681, USA"
            },
            {
                "name": "Bryan A. Baum",
                "org": "Space Science and Engineering Center, University of Wisconsin-Madison, Madison, WI 53706, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy and Radiative Transfer",
        "year": 2011
    },
    "jejUqmJR": {
        "id": "jejUqmJR",
        "title": "A two-habit model for the microphysical and optical properties of ice clouds",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "chao liu",
                "org": "texas a m university"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "patrick minnis",
                "org": "langley research center"
            },
            {
                "name": "norman g loeb",
                "org": "langley research center"
            },
            {
                "name": "seiji kato",
                "org": "langley research center"
            },
            {
                "name": "andrew j heymsfield",
                "org": "national center for atmospheric research"
            },
            {
                "name": "carl schmitt",
                "org": "national center for atmospheric research"
            }
        ],
        "venue": "Atmospheric Chemistry and Physics",
        "year": 2014
    },
    "NrRjqx6E": {
        "id": "NrRjqx6E",
        "title": "A Brief Review of Mueller Matrix Calculations Associated with Oceanic Particles",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Bingqiang Sun",
                "org": ""
            },
            {
                "name": "George Kattawar",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Xiaodong Zhang",
                "org": ""
            }
        ],
        "venue": "Applied Sciences",
        "year": 2018
    },
    "vESGmWye": {
        "id": "vESGmWye",
        "title": "Improved ice particle optical property simulations in the ultraviolet to far-infrared regime",
        "abstract": "Abstract   To derive the bulk radiative properties of ice clouds, aircraft contrails and snow grains, which are fundamental to atmospheric radiative transfer calculations in downstream applications, it is necessary to accurately simulate the scattering of light by individual ice particles. An ice particle optical property database reported in 2013 (hereafter, TAMUice2013) is updated (hereafter, TAMUice2016) to incorporate recent advances in computation of the optical properties of nonspherical particles. Specifically, we employ the invariant imbedding T-matrix (II-TM) method to compute the optical properties of particles with small to moderate size parameters. Both versions use the Improved Geometric Optics Method (IGOM) to compute the optical properties of large ice crystals, but TAMUice2016 improves the treatment of inhomogeneous waves inside the scattering particles in the case where ice is absorptive such as at infrared wavelengths. To bridge the gap between the extinction efficiencies computed from the II-TM and the IGOM, TAMUice2016 includes spectrally dependent higher order terms of the edge effect in addition to the first order counterpart considered in TAMUice2013. Furthermore, the differences between TAMUice2013 and TAMUice2016 are quantified with respect to the computation of the bulk optical properties of ice clouds.",
        "keywords": "",
        "authors": [
            {
                "name": "Lei Bi",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2017
    },
    "7PTgaqZk": {
        "id": "7PTgaqZk",
        "title": "Stochastic parameterization for light absorption by internally mixed BC/dust in snow grains for application to climate models",
        "abstract": "",
        "keywords": [
            "solar radiation",
            "black carbon"
        ],
        "authors": [
            {
                "name": "k n liou",
                "org": "university of california"
            },
            {
                "name": "y takano",
                "org": "university of california"
            },
            {
                "name": "chengjian he",
                "org": "university of california"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "l r leung",
                "org": "pacific northwest national laboratory"
            },
            {
                "name": "yu gu",
                "org": "university of california"
            },
            {
                "name": "w l lee",
                "org": "academia sinica"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2014
    },
    "ZWkNmfxm": {
        "id": "ZWkNmfxm",
        "title": "Intensity and polarization of dust aerosols over polarized anisotropic surfaces",
        "abstract": "",
        "keywords": [
            "remote sensing"
        ],
        "authors": [
            {
                "name": "k n liou",
                "org": ""
            },
            {
                "name": "y takano",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2013
    },
    "qRa7JKNe": {
        "id": "qRa7JKNe",
        "title": "Parameterization of contrail radiative properties for climate studies",
        "abstract": "",
        "keywords": [
            "parameterization"
        ],
        "authors": [
            {
                "name": "yu xie",
                "org": "texas a m university"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "kuonan liou",
                "org": "university of california los angeles"
            },
            {
                "name": "patrick minnis",
                "org": "langley research center"
            },
            {
                "name": "david p duda",
                "org": ""
            }
        ],
        "venue": "Geophysical Research Letters",
        "year": 2012
    },
    "GR1iVM3i": {
        "id": "GR1iVM3i",
        "title": "Validation of a weather forecast model at radiance level against satellite observations allowing quantification of temperature, humidity, and cloud-related biases: Validation of a weather forecast model at radiance level against satellite observations",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Maziar Bani Shahabadi",
                "org": "Department of Atmospheric and Oceanic Sciences; McGill University; Montreal Quebec Canada"
            },
            {
                "name": "Yi Huang",
                "org": "Department of Atmospheric and Oceanic Sciences; McGill University; Montreal Quebec Canada"
            },
            {
                "name": "Louis Garand",
                "org": "Environment Canada; Dorval Quebec Canada"
            },
            {
                "name": "Sylvain Heilliette",
                "org": "Environment Canada; Dorval Quebec Canada"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences; Texas A&M University, College Station; Texas USA"
            }
        ],
        "venue": "Journal of Advances in Modeling Earth Systems",
        "year": 2016
    },
    "qMEhGtRC": {
        "id": "qMEhGtRC",
        "title": "An Efficient Method for Microphysical Property Retrievals in Vertically Inhomogeneous Marine Water Clouds Using MODIS-CloudSat Measurements",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Masanori Saito",
                "org": "Department of Atmospheric Sciences; Texas A&M University; College Station TX USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences; Texas A&M University; College Station TX USA"
            },
            {
                "name": "Yongxiang Hu",
                "org": "NASA Langley Research Center; Hampton VA USA"
            },
            {
                "name": "Xu Liu",
                "org": "NASA Langley Research Center; Hampton VA USA"
            },
            {
                "name": "Norman Loeb",
                "org": "NASA Langley Research Center; Hampton VA USA"
            },
            {
                "name": "William L. Smith",
                "org": "NASA Langley Research Center; Hampton VA USA"
            },
            {
                "name": "Patrick Minnis",
                "org": "NASA Langley Research Center; Hampton VA USA"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2019
    },
    "Gaw20aE5": {
        "id": "Gaw20aE5",
        "title": "Comparing irradiance fields derived from Moderate Resolution Imaging Spectroradiometer airborne simulator cirrus cloud retrievals with solar spectral flux radiometer measurements",
        "abstract": "During the Cirrus Regional Study of Tropical Anvils and Cirrus Layers\u2013Florida Area Cirrus Experiment, the Moderate Resolution Imaging Spectroradiometer (MODIS) airborne simulator (MAS) and the solar spectral flux radiometer (SSFR) operated on the same aircraft, the NASA ER-2. While MAS provided two-dimensional horizontal fields of cloud optical thickness and effective ice particle radius, the SSFR measured spectral irradiance in the visible to near-infrared wavelength range (0.3\u20131.7 \u03bcm). The MAS retrievals, along with vertical profiles from a combined radar/lidar system on board the same aircraft were used to construct three-dimensional cloud fields, which were input into Monte Carlo radiative transfer models. The simulated field of spectral albedo (ratio of reflected upwelling to incident downwelling irradiance) was compared with the SSFR measurements. For two cases, the relative importance of spatial cloud heterogeneities, various approximations of the single scattering parameters, vertical structure, cirrus optical thickness, and ice crystal effective radius was studied.",
        "keywords": [
            "cloud inhomogeneity",
            "spectral irradiance",
            "cloud generator",
            "near infrared",
            "monte carlo",
            "remote sensing",
            "three dimensional",
            "radiative transfer model"
        ],
        "authors": [
            {
                "name": "K. Sebastian Schmidt",
                "org": ""
            },
            {
                "name": "Peter Pilewskie",
                "org": ""
            },
            {
                "name": "Steven Platnick",
                "org": ""
            },
            {
                "name": "Gala Wind",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Manfred Wendisch",
                "org": ""
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2007
    },
    "4KrjTB4f": {
        "id": "4KrjTB4f",
        "title": "A new look at anomalous diffraction theory (ADT): Algorithm in cumulative projected-area distribution domain and modified ADT",
        "abstract": "Two recent papers (Opt. Lett. 28 (2003) 179; Appl. Opt. 42 (2003) 6710) show that the conventional anomalous diffraction theory (ADT) can be reformulated by using the probability distribution function of the geometrical paths of rays inside a scattering particle. In this study we further enhance the new ADT formulation by introducing a dimensionless scaled projectile-length ( l \u02dc q ) defined in the domain of the cumulative projected-area distribution ( q ) of a particle. The quantity l \u02dc q contains essentially all the information about particle shape and aspect ratio, which, however, is independent of particle dimension (e.g., large and small spheres have the same l \u02dc q ). With this feature of l \u02dc q , the present ADT algorithm is computationally efficient if a number of particle sizes and wavelengths are considered, particularly when a random orientation condition is assumed. Furthermore, according to the fundamental ADT assumption regarding the internal field within a scattering particle, we modify ADT on the basis of two rigorous relationships that relate the extinction and absorption cross sections to the internal field. Two tuning factors are introduced in the modified ADT solution, which can be determined for spheres by fitting the modified ADT results to the corresponding Lorenz-Mie solutions. For nonspherical particles, the tuning factors obtained for spheres can be used as surrogates. This approach is tested for the case of circular cylinders whose optical properties can be accurately calculated from the T-matrix method. Numerical computations show that the modified ADT solution is more accurate than its conventional ADT counterpart.",
        "keywords": [
            "anomalous diffraction theory",
            "algorithm",
            "extinction and absorption",
            "probability distribution function",
            "cumulant",
            "cross section",
            "aspect ratio",
            "particle size"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Zhibo Zhang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, TAMU 3150, College Station, TX 77843, USA"
            },
            {
                "name": "Bryan A. Baum",
                "org": "NASA Langley Research Center, Hampton, VA 23681, USA"
            },
            {
                "name": "Hung-Lung Huang",
                "org": "Cooperative Institute for Meteorological Satellite Studies, University of Wisconsin-Madison, 1225 W. Dayton Street, Madison, WI 53706, USA"
            },
            {
                "name": "Yongxiang Hu",
                "org": "NASA Langley Research Center, Hampton, VA 23681, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy and Radiative Transfer",
        "year": 2004
    },
    "0BAKDer8": {
        "id": "0BAKDer8",
        "title": "ON THE POTENTIAL FOR OVERLAPPING CLOUD DETECTION IN HIGH SPECTRAL RESOLUTION INFRARED DATA",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Shaima L. Nasiri",
                "org": "University of Wisconsin"
            },
            {
                "name": "Robert E. Holz",
                "org": "University of Wisconsin"
            },
            {
                "name": "Bryan A. Baum",
                "org": "NASA Langley Research Center"
            },
            {
                "name": "Steven A. Ackerman",
                "org": "University of Wisconsin"
            },
            {
                "name": "Ping Yang",
                "org": "Texas A&M University"
            }
        ],
        "venue": "",
        "year": 0
    },
    "xXQTOgjn": {
        "id": "xXQTOgjn",
        "title": "On the aerosol and cloud phase function expansion moments for radiative transfer simulations: AEROSOL/CLOUD PHASE FUNCTION MOMENTS",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jiangnan Li",
                "org": "Canadian Centre for Climate Modelling and Analysis; Science and Technology Branch, Environment Canada; Victoria British Columbia Canada"
            },
            {
                "name": "Howard W. Barker",
                "org": "Cloud Physics Research Division; Environment Canada; Downsview Ontario Canada"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences; Texas A&M University; College Station Texas USA"
            },
            {
                "name": "Bingqi Yi",
                "org": "Department of Atmospheric Sciences; Texas A&M University; College Station Texas USA"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2015
    },
    "TFiEznpi": {
        "id": "TFiEznpi",
        "title": "Retrieval of semitransparent ice cloud optical thickness from atmospheric infrared sounder (AIRS) measurements",
        "abstract": "An approach is developed to infer the optical thick- ness of semitransparent ice clouds (when optical thickness is less than 5) from Atmospheric Infrared Sounder (AIRS) high spectral resolution radiances. A fast cloud radiance model is developed and coupled with an AIRS clear-sky radiative transfer model for simu- lating AIRS radiances when ice clouds are present. Compared with more accurate calculations based on the discrete ordinates radia- tive transfer model, the accuracy of the fast cloud radiance model is within 0.5 K (root mean square) in terms of brightness temperature (BT) and runs three orders of magnitude faster. We investigate the sensitivity of AIRS spectral BTs and brightness temperature dif- ference (BTD) values between pairs of wavenumbers to the cloud optical thickness. The spectral BTs for the atmospheric window channels within the region 1070-1135 cm are sensitive to the ice cloud optical thickness, as is the BTD between 900.562 cm (located in an atmospheric window) and 1558.692 cm (located in a strong water vapor absorption band). Similarly, the BTD be- tween a moderate absorption channel (1587.495 cm ) and the strong water absorption channel (1558.692 cm ) is sensitive to ice cloud optical thickness. Neither of the aforementioned BTDs is sensitive to the effective particle size. Thus, the optical thickness of semitransparent ice clouds can be retrieved reliably. We have developed a spectrum-based approach and a BTD-based method to retrieve the optical thickness of semitransparent ice clouds. The present retrieval methods are applied to a granule of AIRS data. The ice cloud optical thicknesses derived from the AIRS measure- ments are compared with those retrieved from the Moderate Res- olution Imaging Spectroradiometer (MODIS) 1.38- and 0.645- m bands. The optical thicknesses inferred from the MODIS measure- ments are collocated and degraded to the AIRS spatial resolution. Results from the MODIS and AIRS retrievals are in reasonable agreement over a wide range of optical thicknesses.",
        "keywords": [
            "index terms\u2014atmospheric infrared sounder airs",
            "retrieval.",
            "optical thickness",
            "infrared radiation transfer",
            "ice clouds",
            "water vapor",
            "infrared",
            "radiative transfer model",
            "spectral resolution",
            "spatial resolution",
            "spectrum",
            "water absorption",
            "root mean square",
            "brightness temperature",
            "radiative transfer",
            "particle size",
            "atmospheric optics",
            "remote sensing"
        ],
        "authors": [
            {
                "name": "Heli Wei",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Jun Li",
                "org": ""
            },
            {
                "name": "Bryan A. Baum",
                "org": ""
            },
            {
                "name": "Hung-Lung Huang",
                "org": ""
            },
            {
                "name": "Steven Platnick",
                "org": ""
            },
            {
                "name": "Yongxiang Hu",
                "org": ""
            },
            {
                "name": "Larrabee Strow",
                "org": ""
            }
        ],
        "venue": "IEEE T. Geoscience and Remote Sensing",
        "year": 2004
    },
    "FORWDISR": {
        "id": "FORWDISR",
        "title": "Enhanced lidar backscattering by quasi-horizontally oriented ice crystal plates in cirrus clouds",
        "abstract": "The backscattering of light by quasi-horizontally oriented hexagonal ice plates is investigated because of its pertinence to lidar measurements of cirrus clouds. For oriented ice crystals, the commonly used geometric optics ray-tracing method is not applicable to the computation of the scattered field in certain scattering directions, in particular, the backscattering direction, because of the singularity problem inherent to the ray-tracing technique. In this study, we solve for the electric field due to scattering by quasi-horizontally oriented ice plates using an approach based on the electromagnetic wave theory. We simplify the analysis by ignoring the effect of the plate's side faces on the internal field inside the particle. This is a reasonable approximation when the ratio of the particle diameter to its thickness is large. This approximation is also valid if the tilt of the particle's symmetric axis from zenith is small and the size parameter is large. The present numerical results indicate that very strong oscillations in the backscattering cross section occur with the variation of size parameter. Furthermore, the bulk backscattering intensity has been calculated by including the effect of a particle size distribution and the random tilt of particle symmetric axis within a small angular region, for example, 2\u00b0. A strong dependence is found between the lidar backscattering cross section and the degree of the random tilt of the particles. A combination of the present method with the T-matrix method, which works well for particles having small and moderate size parameters, may provide a more complete picture of the lidar backscattering by quasi-horizontally oriented ice plates.",
        "keywords": [
            "ice plates",
            "lidar",
            "cirrus clouds",
            "backscattering",
            "electromagnetic waves",
            "oscillations",
            "geometric optics",
            "cross section",
            "particle size distribution",
            "ray tracing",
            "electric field"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Yong X. Hu",
                "org": "NASA Langley Research Center, MS 420, Hampton, VA 23681, USA"
            },
            {
                "name": "David M. Winker",
                "org": "NASA Langley Research Center, MS 420, Hampton, VA 23681, USA"
            },
            {
                "name": "Jun Zhao",
                "org": "Department of Mathematics, Texas A&M University, College Station, TX 77843, USA"
            },
            {
                "name": "Chris A. Hostetler",
                "org": "NASA Langley Research Center, MS 420, Hampton, VA 23681, USA"
            },
            {
                "name": "Lamont Poole",
                "org": "NASA Langley Research Center, MS 420, Hampton, VA 23681, USA"
            },
            {
                "name": "Bryan A. Baum",
                "org": "NASA Langley Research Center, MS 420, Hampton, VA 23681, USA"
            },
            {
                "name": "Michael I. Mishchenko",
                "org": "NASA Goddard Institute for Space Studies, New York, NY 10025, USA"
            },
            {
                "name": "Jens Reichardt",
                "org": "Code 916, NASA Goddard Space Flight Center, Greenbelt, MD 20771, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy and Radiative Transfer",
        "year": 2003
    },
    "4DwXhzXn": {
        "id": "4DwXhzXn",
        "title": "Improved delta-Eddington approximation for optically thin clouds",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Tong Ren",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX"
            },
            {
                "name": "Guanglin Tang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX"
            },
            {
                "name": "Xianglei Huang",
                "org": "Dept. of Climate and Space Sciences and Engineering University of Michigan Ann Arbor MI"
            },
            {
                "name": "Eli Mlawer",
                "org": "Atmospheric and Environmental Research, Lexington, MA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2020
    },
    "CmFWCYqj": {
        "id": "CmFWCYqj",
        "title": "Effect of Particle Shape, Density, and Inhomogeneity on the Microwave Optical Properties of Graupel and Hailstones.",
        "abstract": "Atmospheric ice particles can be rimed and contaminated (e.g., by soot attachments). Previous optical property calculations usually assume rimed particles such as graupel and hailstones to be homogeneous spheres with fixed densities. The relevant dielectric constants are estimated with the effective medium approximation (EMA), although such particles are predominately nonspherical, porous, and contain small interior grains. This paper assesses the effects of nonsphericity, density, and inhomogeneity of graupel and hailstones on their optical properties. The bicontinuous medium approximation (BMA) is employed to simulate the particle internal structure. Conical shapes are compared with spherical and spheroidal shapes to assess the effect of nonsphericity. At frequencies lower than 89 GHz, the optical properties are more sensitive to particle\u2019s mass density than to overall particle shape, and the internal structure plays an insignificant role when the particle effective diameter (a quantity involving the particle size distribution) is smaller than approximately 10 mm, and the internal grain size is smaller than 0.2 mm. With a small grain size, the BMA phase function converges to the EMA phase function with an effective refractive index calculated with the Bruggeman formulation. Simulated top of atmosphere radiances at three microwave frequencies, 18.7, 36.5, and 89 GHz, are quite sensitive to ice particle effective diameter between 1 and 5 mm, ice fraction between 0.1 and 0.9, and ice water path between 1 and 5 kg/   $text{m}^{2}$   . Thus, these frequencies are suitable for retrieving the microphysical properties.",
        "keywords": "",
        "authors": [
            {
                "name": "Guanglin Tang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, USA"
            },
            {
                "name": "Patrick G. Stegmann",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, USA"
            },
            {
                "name": "R. Lee Panetta",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX, USA"
            },
            {
                "name": "Leung Tsang",
                "org": "Department of Electrical Engineering and Computer Science, Radiation Laboratory, University of Michigan, Ann Arbor, MI, USA"
            },
            {
                "name": "Benjamin Johnson",
                "org": ""
            }
        ],
        "venue": "IEEE Trans. Geoscience and Remote Sensing",
        "year": 2017
    },
    "8qBLsL5g": {
        "id": "8qBLsL5g",
        "title": "Retrieval of Ice Cloud Optical Thickness and Effective Particle Size Using a Fast Infrared Radiative Transfer Model",
        "abstract": "",
        "keywords": [
            "algorithms"
        ],
        "authors": [
            {
                "name": "chenxi wang",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "bryan a baum",
                "org": ""
            },
            {
                "name": "steven platnick",
                "org": ""
            },
            {
                "name": "andrew k heidinger",
                "org": ""
            },
            {
                "name": "yongxiang hu",
                "org": ""
            },
            {
                "name": "robert e holz",
                "org": ""
            }
        ],
        "venue": "Journal of Applied Meteorology and Climatology",
        "year": 2011
    },
    "kjeuE13U": {
        "id": "kjeuE13U",
        "title": "A New Parameterization of Single Scattering Solar Radiative Properties for Tropical Anvils Using Observed Ice Crystal Size and Shape Distributions",
        "abstract": "ABSTRACT Parameterizations of single scattering properties currently used in cloud resolving and general circulation models are somewhat limited in that they typically assume the presence of single particle habits, do not adequately account for the numbers of ice crystals with diameters smaller than 100 mm, and contain no information about the variance of parameterization coefficients. Here, new parameterizations of mean single scattering properties (e.g., single scatter albedo, asymmetry parameter, and extinction efficiency) for distributions of ice crystals in tropical anvils are developed. Using information about the size and shape of ice crystals acquired by a two- dimensional cloud probe during the Central Equatorial Pacific Experiment (CEPEX), a self-organized neural network,defines shape based on simulations of how,the particle maximum,dimension,and area ratio (ratio of projected area to that of circumscribed,circle with maximum,dimension) vary for random,orientations of different idealized shapes (i.e., columns, bullet rosettes, rough aggregates, and particles represented by Chebyshev poly- nomials). The size distributions for ice crystals smaller than 100 mm are based on parameterizations developed using representative samples,of 11 633 crystals imaged,by a video ice particle sampler (VIPS). The mean- scattering properties for distributions of ice crystals are then determined,by weighting,the single scattering properties of individual ice crystals, determined using an improved geometric ray-tracing method, according to number,concentration and scattering cross section. The featureless nature of the calculated phase function, averaged over all observed sizes and shapes of ice crystals, is similar to that obtained using other schemes designed to account for variations in sizes and shapes of ice crystals. The new parameterizations of single scatter albedo, asymmetry parameter, and extinction efficiency are then determined,by functional fits in terms of cloud particle effective radius; there was no statistically significant dependence,on either ice water content or temperature. Uncertainty estimates incorporated into the parameterization coefficients are based upon a Monte Carlo approach. Comparisons,with previously used pa- rameterizations and with parameterizations developed,using single crystal habits are made,to show,that the",
        "keywords": [],
        "authors": [
            {
                "name": "Greg M. McFarquhar",
                "org": "Department of Atmospheric Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, Texas"
            },
            {
                "name": "Andreas Macke",
                "org": "Institut fuer Meereskunde, Universitat zu Kiel, Cologne, Germany"
            },
            {
                "name": "Anthony J. Baran",
                "org": ""
            }
        ],
        "venue": "Journal of The Atmospheric Sciences",
        "year": 2002
    },
    "jHD1uba4": {
        "id": "jHD1uba4",
        "title": "Polarized extinction properties of plates with large aspect ratios",
        "abstract": "",
        "keywords": [
            "polarization",
            "interference",
            "extinction",
            "scattering"
        ],
        "authors": [
            {
                "name": "meng gao",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "george w kattawar",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2013
    },
    "GPTsgG8H": {
        "id": "GPTsgG8H",
        "title": "Scattering of 1-D periodic scatterer and asymptotic comparison using the many-body iterative T-matrix method",
        "abstract": "",
        "keywords": [
            "t matrix method",
            "scattering"
        ],
        "authors": [
            {
                "name": "bingqiang sun",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "george w kattawar",
                "org": ""
            },
            {
                "name": "lei bi",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2014
    },
    "Ur8eI0Cl": {
        "id": "Ur8eI0Cl",
        "title": "Ice particle habit and surface roughness derived from PARASOL polarization measurements",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "benjamin h cole",
                "org": "texas a m university"
            },
            {
                "name": "ping yang",
                "org": "texas a m university"
            },
            {
                "name": "bryan a baum",
                "org": "university of wisconsin madison"
            },
            {
                "name": "jerome riedi",
                "org": "centre national de la recherche scientifique"
            },
            {
                "name": "laurent c labonnote",
                "org": "centre national de la recherche scientifique"
            }
        ],
        "venue": "Atmospheric Chemistry and Physics",
        "year": 2014
    },
    "qlieEsu9": {
        "id": "qlieEsu9",
        "title": "A fast radiative transfer model for visible through shortwave infrared spectral reflectances in clear and cloudy atmospheres",
        "abstract": "",
        "keywords": [
            "radiative transfer"
        ],
        "authors": [
            {
                "name": "chenxi wang",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "shaima l nasiri",
                "org": ""
            },
            {
                "name": "steven platnick",
                "org": ""
            },
            {
                "name": "bryan a baum",
                "org": ""
            },
            {
                "name": "andrew k heidinger",
                "org": ""
            },
            {
                "name": "xu liu",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2013
    },
    "Ly33YvNO": {
        "id": "Ly33YvNO",
        "title": "MODELING OF LIGHT SCATTERING BY SINGLE RED BLOOD CELLS WITH THE FDTD METHOD",
        "abstract": "Scattering of light is one of major pathways that biological cells interact with optical radiation in a wide spectral region\n from ultraviolet to near-infrared. In this region the size parameters of most human cells vary from about 10 to 100, and accurate\n modeling of scattering requires treatment of light as electromagnetic waves. In this chapter, we review the generic aspects\n of the finite-difference-time-domain (FDTD) method for solving the problems of light scattering by biological cells and a\n parallel FDTD algorithm for numerical computation. Furthermore, we review a specific application of FDTD to the simulation\n of the scattering properties of single human red blood cells with biconcave and deformed shapes.\n ",
        "keywords": [
            "parallel computing",
            "fdtd method",
            "red blood cells.",
            "light scattering"
        ],
        "authors": [
            {
                "name": "Jun Q. Lu",
                "org": "Department of Physics, East Carolina University, 27858 Greenville, NC U.S.A."
            },
            {
                "name": "R. Scott Brock",
                "org": "Department of Physics, East Carolina University, 27858 Greenville, NC U.S.A."
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX77843 U.S.A."
            },
            {
                "name": "Xin-Hua Hu",
                "org": "Department of Physics, East Carolina University, 27858 Greenville, NC U.S.A."
            }
        ],
        "venue": "",
        "year": 2007
    },
    "QMo0e7UW": {
        "id": "QMo0e7UW",
        "title": "Internal electromagnetic waves, energy trapping, and energy release in simple time-domain simulations of single particle scattering.",
        "abstract": "Abstract   During the decay phase of the interaction of a femto-second Gaussian pulse with a single spherical particle, the presence of quasi-periodic short oscillatory bursts of electromagnetic energy at points in the near field outside the particle have been observed in three-dimensional simulations. Analogous behavior can be very easy produced and understood in simple one-dimensional scattering calculations. In two dimensions the situation immediately becomes more complicated and interesting. Here we discuss results from two-dimensional pseudo-spectral time-domain simulations of scattering from circular, elliptical, and hexagonal particles with the real index of refraction m=1.3. Our focus is on how energy initially trapped within a particle after interaction with an incident Gaussian pulse is released over time, and we show two kinds of events that can result in \u201cbursts\u201d of energy release from the particles: (i) the coalescence of counter-propagating wave-packet-like electromagnetic field structures that have maximum amplitude near the surface of the particle, and (ii) encounters of individual packets with surface regions of high curvature. The coalescence events in the circular case show the dynamical origin of a two-dimensional form of \u201cphotonic nanojet.\u201d The two-dimensional simulations make clear the reason for quasi-periodic intermittent bursts at fixed near-field points outside the particle. Examination of field evolution shows that distinct near-surface internal field maxima, ostensibly the \u201csource\u201d of the emission bursts, are in fact inter-connected by caustic-like internal field structures that extend throughout the particle and have complex time evolution. The revealed intricacy of these connections suggests that understanding the origins of pulsed emissions in three dimensions, even for simple particle geometries, may be quite challenging.",
        "keywords": "",
        "authors": [
            {
                "name": "R. Lee Panetta",
                "org": "Department of Atmospheric Sciences, Texas A&M University"
            },
            {
                "name": "Siyao Zhai",
                "org": "Department of Atmospheric Sciences, Texas A&M University"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2019
    },
    "95xJ0WKN": {
        "id": "95xJ0WKN",
        "title": "Far-field Lorenz\u2013Mie scattering in an absorbing host medium: Theoretical formalism and FORTRAN program",
        "abstract": "Abstract   In this paper we make practical use of the recently developed first-principles approach to electromagnetic scattering by particles immersed in an unbounded absorbing host medium. Specifically, we introduce an actual computational tool for the calculation of pertinent far-field optical observables in the context of the classical Lorenz\u2013Mie theory. The paper summarizes the relevant theoretical formalism, explains various aspects of the corresponding numerical algorithm, specifies the input and output parameters of a FORTRAN program available at  https://www.giss.nasa.gov/staff/mmishchenko/Lorenz-Mie.html , and tabulates benchmark results useful for testing purposes. This public-domain FORTRAN program enables one to solve the following two important problems: (i) simulate theoretically the reading of a remote well-collimated radiometer measuring electromagnetic scattering by an individual spherical particle or a small random group of spherical particles; and (ii) compute the single-scattering parameters that enter the vector radiative transfer equation derived directly from the Maxwell equations.",
        "keywords": "",
        "authors": [
            {
                "name": "Michael I. Mishchenko",
                "org": "NASA Goddard Institute for Space Studies, 2880 Broadway, New York, NY 10025, USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA"
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2018
    },
    "SCQxaTV3": {
        "id": "SCQxaTV3",
        "title": "Coupling of the microphysical and optical properties of an Arctic nimbostratus cloud during the ASTAR 2004 experiment: Implications for light-scattering modeling",
        "abstract": "Airborne measurements in an Arctic mixed-phase nimbostratus cloud were conducted in Spitsbergen on 21 May 2004 during the international Arctic Study of Tropospheric Aerosol, Clouds and Radiation (ASTAR) campaign. The in situ instrument suite aboard the Alfred Wegener Institute Polar 2 aircraft included a polar nephelometer (PN), a cloud particle imager (CPI), a Nevzorov probe, and a standard PMS 2DC probe to measure the cloud particle single-scattering properties (at a wavelength of 0.8 \u03bcm), and the particle morphology and size, as well as the in-cloud partitioning of ice/water content. The main objective of this work is to present a technique based on principal component analysis and light-scattering modeling to link the microphysical properties of cloud particles to their optical characteristics. The technique is applied to the data collected during the 21 May case study where a wide variety of ice crystal shapes and liquid water fractions were observed at temperatures ranging from \u22121\u00b0C to \u221212\u00b0C. CPI measurements highlight the presence of large supercooled water droplets with diameters close to 500 \u03bcm. Although the majority of ice particles were found to have irregular shapes, columns and needles were the prevailing regular habits between \u22123\u00b0C and \u22126\u00b0C while stellars and plates were observed at temperatures below \u22128\u00b0C. The implementation of the principal component analysis of the PN scattering phase function measurements revealed representative optical patterns that were consistent with the particle habit classification derived from the CPI. This indicates that the synergy between the CPI and the PN can be exploited to link the microphysical and shape properties of cloud particles to their single-scattering characteristics. Using light-scattering modeling, we have established equivalent microphysical models based on a limited set of free parameters (roughness, mixture of idealized particle habits, and aspect ratio of ice crystals) that reproduce the main optical features assessed for cloud regions with different particle geometries and liquid water fractions. However, the retrieved bulk microphysical parameters can substantially differ from the measurements (by several times for the effective size and up to 3 orders of magnitude for the number concentration). Several possible explanations for these discrepancies are discussed. The retrievals show that the optical contribution of small particles with sizes lower than 50 \u03bcm (droplets and ice crystals) is significant, always exceeding 50% of the total scattering signal, and thus needs to be more accurately quantified. The shattering of large ice crystals on the shrouded inlet of the PN could also strongly affect the retrieved microphysical parameters.",
        "keywords": [
            "light-scattering modeling",
            "cloud optics",
            "cloud microphysics",
            "limit set",
            "effect size",
            "light scattering",
            "principal component analysis",
            "data collection",
            "aspect ratio"
        ],
        "authors": [
            {
                "name": "Olivier Jourdan",
                "org": "Laboratoire de M\u00e9t\u00e9orologie Physique, Universit\u00e9 Blaise Pascal, OPGC/CNRS UMR 6016, Clermont-Ferrand, France"
            },
            {
                "name": "Guillaume Mioche",
                "org": "Laboratoire de M\u00e9t\u00e9orologie Physique, Universit\u00e9 Blaise Pascal, OPGC/CNRS UMR 6016, Clermont-Ferrand, France"
            },
            {
                "name": "Timothy J. Garrett",
                "org": "Department of Atmospheric Sciences, University of Utah, Salt Lake City, Utah, USA"
            },
            {
                "name": "Alfons Schwarzenb\u00f6ck",
                "org": "Laboratoire de M\u00e9t\u00e9orologie Physique, Universit\u00e9 Blaise Pascal, OPGC/CNRS UMR 6016, Clermont-Ferrand, France"
            },
            {
                "name": "J\u00e9r\u00f4me Vidot",
                "org": "Laboratoire de M\u00e9t\u00e9orologie Physique, Universit\u00e9 Blaise Pascal, OPGC/CNRS UMR 6016, Clermont-Ferrand, France"
            },
            {
                "name": "Yu Xie",
                "org": "Department of Atmospheric Sciences, Texas A&amp;M University, College Station, Texas, USA"
            },
            {
                "name": "Valery Shcherbakov",
                "org": "Laboratoire de M\u00e9t\u00e9orologie Physique, Universit\u00e9 Blaise Pascal, OPGC/CNRS UMR 6016, Clermont-Ferrand, France,Laboratoire de M\u00e9t\u00e9orologie Physique, Institut Universitaire de Technologie de Montlu\u00e7on, Montlu\u00e7on, France"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&amp;M University, College Station, Texas, USA"
            },
            {
                "name": "Jean-Fran\u00e7ois Gayet",
                "org": "Laboratoire de M\u00e9t\u00e9orologie Physique, Universit\u00e9 Blaise Pascal, OPGC/CNRS UMR 6016, Clermont-Ferrand, France"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2010
    },
    "5rHJHDqe": {
        "id": "5rHJHDqe",
        "title": "Comparison of the pseudo-spectral time domain method and the discrete dipole approximation for light scattering by ice spheres",
        "abstract": "",
        "keywords": [
            "light scattering"
        ],
        "authors": [
            {
                "name": "derek i podowitz",
                "org": ""
            },
            {
                "name": "chao liu",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "maxim a yurkin",
                "org": ""
            }
        ],
        "venue": "Journal of Quantitative Spectroscopy & Radiative Transfer",
        "year": 2014
    },
    "TAg7EnJx": {
        "id": "TAg7EnJx",
        "title": "Retrieval of ice cloud properties using an optimal estimation algorithm and MODIS infrared observations: 1. Forward model, error analysis, and information content: IR-Based Ice Cloud Retrieval Algorithm",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Chenxi Wang",
                "org": "Earth System Science Interdisciplinary Center; University of Maryland; College Park Maryland USA"
            },
            {
                "name": "Steven Platnick",
                "org": "NASA Goddard Space Flight Center; Greenbelt Maryland USA"
            },
            {
                "name": "Zhibo Zhang",
                "org": "Department of Physics; University of Maryland, Baltimore County; Baltimore Maryland USA"
            },
            {
                "name": "Kerry Meyer",
                "org": "NASA Goddard Space Flight Center; Greenbelt Maryland USA"
            },
            {
                "name": "Kerry Meyer",
                "org": "NASA Goddard Space Flight Center; Greenbelt Maryland USA"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences; Texas A&M University; College Station Texas USA"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2016
    },
    "xktvSbIp": {
        "id": "xktvSbIp",
        "title": "On the Convergence of Numerical Computations for Both Exact and Approximate Solutions for Electromagnetic Scattering by Nonspherical Dielectric Particles (Invited Review)",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Jiachen Ding",
                "org": ""
            },
            {
                "name": "Richard Lee Panetta",
                "org": ""
            },
            {
                "name": "Kuo-Nan Liou",
                "org": ""
            },
            {
                "name": "George W. Kattawar",
                "org": ""
            },
            {
                "name": "Michael I. Mishchenko",
                "org": ""
            }
        ],
        "venue": "Progress in Electromagnetics Research-pier",
        "year": 2019
    },
    "C9A994ae": {
        "id": "C9A994ae",
        "title": "Geometrical-optics solution to light scattering by droxtal ice crystals.",
        "abstract": "We investigate the phase matrices of droxtals at wavelengths of 0.66 and 11 microm by using an improved geometrical-optics method. An efficient method is developed to specify the incident rays and the corresponding impinging points on the particle surface necessary to initialize the ray-tracing computations. At the 0.66-microm wavelength, the optical properties of droxtals are different from those of hexagonal ice crystals. At the 11-microm wavelength, the phase functions for droxtals are essentially featureless because of strong absorption within the particles, except for ripple structures that are caused by the phase interference of the diffracted wave.",
        "keywords": [
            "light scattering",
            "atmospheric scattering",
            "meteorology",
            "geometric optics",
            "atmospheric optics",
            "ray tracing"
        ],
        "authors": [
            {
                "name": "Zhibo Zhang",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "George W Kattawar",
                "org": ""
            },
            {
                "name": "Si-Chee Tsay",
                "org": ""
            },
            {
                "name": "Bryan A Baum",
                "org": ""
            },
            {
                "name": "Yongxiang Hu",
                "org": ""
            },
            {
                "name": "Andrew J Heymsfield",
                "org": ""
            },
            {
                "name": "Jens Reichardt",
                "org": ""
            }
        ],
        "venue": "Applied optics",
        "year": 2004
    },
    "PT7SfH8k": {
        "id": "PT7SfH8k",
        "title": "Retrieval of polar stratospheric cloud microphysical properties from lidar measurements: Dependence on particle shape assumptions : SAGE III-Ozone Loss Validation Experiment and Third European Stratospheric Experiment on Ozone-2000 (SOLVE/THESEO)",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jens Reichardt",
                "org": ""
            },
            {
                "name": "S. Reichardt",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "T. J. McGee",
                "org": ""
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2002
    },
    "7i0419BY": {
        "id": "7i0419BY",
        "title": "On the Convergence of Numerical Computations for Both Exact and Approximate Solutions for Electromagnetic Scattering by Nonspherical Dielectric Particles.",
        "abstract": "We summarize the size parameter range of the applicability of four light-scattering computational methods for nonspherical dielectric particles. These methods include two exact methods - the extended boundary condition method (EBCM) and the invariant imbedding T-matrix method (II-TM) and two approximate approaches - the physical-geometric optics method (PGOM) and the improved geometric optics method (IGOM). For spheroids, the single-scattering properties computed by EBCM and II-TM agree for size parameters up to 150, and the comparison gives us confidence in using IITM as a benchmark for size parameters up to 150 for other geometries (e.g., hexagonal columns) because the applicability of II-TM with respect to particle shape is generic, as demonstrated in our previous studies involving a complex aggregate. This study demonstrates the convergence of the exact II-TM and approximate PGOM solutions for the complete set of single-scattering properties of a nonspherical shape other than spheroids and circular cylinders with particle sizes of  48\u03bb(size parameter ~150), specifically a hexagonal column with a length size parameter of  = 300 where  = 2\u03c0\u03bb and  is the column length. IGOM is also quite accurate except near the exact 180\u00b0backscattering direction. This study demonstrates that a synergetic combination of the numerically-exact II-TM and the approximate PGOM can seamlessly cover the entire size parameter range of practical interest. To demonstrate the applicability of the approach, we compute the optical properties of dust particles and demonstrate a downstream application to the retrieval of dust aerosol optical thickness and effective particle size from satellite polarimetric observations.",
        "keywords": "",
        "authors": [
            {
                "name": "Ping Yang",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA."
            },
            {
                "name": "Jiachen Ding",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA."
            },
            {
                "name": "Richard Lee Panetta",
                "org": "Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA."
            },
            {
                "name": "Kuo-Nan Liou",
                "org": "Joint Institute for Regional Earth System Science and Engineering and Department of Atmospheric and Oceanic Sciences, University of California, Los Angeles, CA 90095, USA."
            },
            {
                "name": "George W Kattawar",
                "org": "Department of Physics & Astronomy and Institute for Quantum Science and Engineering, Texas A&M University, College Station, TX 77843, USA."
            },
            {
                "name": "Michael Mishchenko",
                "org": "NASA Goddard Institute for Space Studies, New York, NY 10025, USA."
            }
        ],
        "venue": "Electromagnetic waves (Cambridge, Mass.)",
        "year": 2019
    },
    "ozPvzZa6": {
        "id": "ozPvzZa6",
        "title": "Invisibility cloaks for irregular particles using coordinate transformations.",
        "abstract": "Invisibility cloaks for ellipsoids, rounded cuboids and rounded cylinders have been studied on the basis of the coordinate transformation approach. The resultant material property tensors for irregular cloaks are more complicated in comparison with those for the spherical invisibility cloak. A generalized Discrete Dipole Approximation (DDA) formalism has been used to simulate the scattered field distribution in the vicinity of the aforementioned irregular cloaks illuminated by an incident plane wave. Simulated scattering efficiencies are on the order of 10(-5), and the simulated electric-field distribution outside of a cloak is the same as that of the incident radiation.",
        "keywords": [
            "coordinate transformation",
            "metamaterials",
            "scattering",
            "backscattering"
        ],
        "authors": [
            {
                "name": "Yu You",
                "org": ""
            },
            {
                "name": "George W Kattawar",
                "org": ""
            },
            {
                "name": "Peng-Wang Zhai",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            }
        ],
        "venue": "Optics express",
        "year": 2008
    },
    "WlwDlXzl": {
        "id": "WlwDlXzl",
        "title": "Experimental study of lubrication regime transition in concentrated lubricated contacts",
        "abstract": "The transition between elastohydrodynamic lubrication and hydrodynamic lubrication in a ball-disc contact was experimentally studied. Different lubrication regimes were achieved by applying different loads and entrainment speeds. The results show that there is a transition region between the elastohydrodynamic lubrication and hydrodynamic lubrication regimes. In elastohydrodynamic lubrication and hydrodynamic lubrication, the film thickness bears a linear relationship to the entrainment speed or the load in a log-log scale. However, in the transition region due to the obvious change in elastic deformation with entrainment speeds or loads, there is not a linear relationship between the film thickness and entrainment speeds or loads in a log-log scale. The experimental transition region cannot be predicted by the existing theory for lubrication regime identification.",
        "keywords": [
            "Elastohydrodynamic lubrication",
            "Hydrodynamic lubrication",
            "Interferometry",
            "Lubrication regime"
        ],
        "authors": [
            {
                "name": "ZhongXue Fu",
                "org": "Qingdao TechNological University(Qingdao Technological University),Qingdao,China"
            },
            {
                "name": "Feng Guo",
                "org": "Qingdao TechNological University(Qingdao Technological University),Qingdao,China"
            },
            {
                "name": "Xuefeng Wang",
                "org": "Qingdao TechNological University(Qingdao Technological University),Qingdao,China"
            },
            {
                "name": "Ping Yang",
                "org": "Qingdao TechNological University(Qingdao Technological University),Qingdao,China"
            }
        ],
        "venue": "Run Hua Yu Mi Feng/Lubrication Engineering",
        "year": 2006
    },
    "GLJm3uIG": {
        "id": "GLJm3uIG",
        "title": "Study on the lubrication mechanism of thermal-viscosity wedge regarding some abnormal phenomena in elastohydrodynamic lubrication",
        "abstract": "The main achievements made by the research group of lubrication theory at Qingdao Technological University in the study on the two types of abnormal phenomena in elastohydrodynamic lubrication(EHL) are reviewed.The importance of the thermal-viscosity wedge is fully revealed by the new theory.The correctness of the guesswork done by the older generation regarding the existence of the thermal EHL film under zero-entrainment conditions is proved.The Kaneta's dimples are simulated numerically.Since the surface dimples in EHL was discovered by Kaneta and coworkers in 1992,in order to understand such phenomena,a number of testing theories have been proposed,however,our theory has proved eloquently that Kaneta's dimples were generated by the mechanism of the thermalviscosity wedge,consequently,the importance of this mechanism has received a great attention among the EHL researchers.",
        "keywords": [
            "EHL",
            "Kaneta's dimple",
            "zero-entrainment film",
            "thermal-viscosity wedge"
        ],
        "authors": [
            {
                "name": "YANG Pei-ran",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao "
            },
            {
                "name": "GUO Feng",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao "
            },
            {
                "name": "WANG Jing",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao "
            },
            {
                "name": "LIU Xiao-ling",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao "
            },
            {
                "name": "CUI Jin-lei",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao "
            },
            {
                "name": "YANG Ping",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao "
            }
        ],
        "venue": "Journal of Qingdao Technological University",
        "year": 2006
    },
    "9SWW8lBx": {
        "id": "9SWW8lBx",
        "title": "Thermal Effects on Elastohydrodynamic Lubrication",
        "abstract": "The concept,theoretical development and scientific fundamental of thermal elastohydrodynamic lubrication (EHL) were described.A representative numerical solution of point contact thermal EHL was given.Five types of thermal effects on EHL,i.e.,the relation between the frictional coefficient and slide-roll ratio,the reduction of film thickness caused by the entrance temperature rise,the size effect,the action of thermal viscosity wedge,and the effect of solid bodies,were presented together through numerical examples.Some misunderstandings existed in lubrication engineering were clarified.The main difficulty faced currently for the thermal EHL research was pointed out,and the future development of thermal EHL theory was predicted.",
        "keywords": [
            "thermal viscosity wedge",
            "size effect",
            "slide-roll ratio",
            "thermal EHL",
            "entrance temperature rise"
        ],
        "authors": [
            {
                "name": "Yang Peiran",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao Shandong ,China"
            },
            {
                "name": "Liu Xiaoling",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao Shandong ,China"
            },
            {
                "name": "Cui Jinlei",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao Shandong ,China"
            },
            {
                "name": "Yang Ping",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao Shandong ,China"
            }
        ],
        "venue": "Lubrication Engineering",
        "year": 2010
    },
    "uXZhjl7u": {
        "id": "uXZhjl7u",
        "title": "The Influences of Bump and Groove on the Thermal Elastohydrodynamic Lubrication of Involute Spur Gear",
        "abstract": "With the multi-grid method,the influences of surface roughness on the non-Newtonian thermal elastohydrodynamic lubrication of involute spur gear were investigated.The effects of bump and groove were analyzed respectively,and the effects of the same contact line and different engaging points were discussed.The results with bump and grove were compared with those of smooth surfaces.It is found from the numerical results that,the single spike and double spikes appear due to the bump and groove in the distribution of pressure,and there are few changes in the distribution of the film thickness.",
        "keywords": [
            "non-Newtonian thermal elastohydrodynamic lubrication",
            "involute spur gear",
            "groove",
            "bump"
        ],
        "authors": [
            {
                "name": "He Zhicheng",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao Shandong ,China"
            },
            {
                "name": "Yang Ping",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao Shandong ,China"
            },
            {
                "name": "Wang Youqiang",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao Shandong ,China"
            }
        ],
        "venue": "Lubrication Engineering",
        "year": 2007
    },
    "RU17YXoW": {
        "id": "RU17YXoW",
        "title": "Analysis of tapered roller EHL considering moment balance",
        "abstract": "Numerical analysis was carried out for elastohydrodynamic lubrication (EHL) of tapered roller considering moment balance. The equation of moment balance, corresponding to the discrete method and the formula of relative error were given. Position angle of roller changed with the relative error in order to satisfy the moment balance. When considering the moment balance, effects of load, velocity and half-tapered angle on the position angle of roller, pressure and film thickness were analyzed. Results showed that, if load is in the geometrical center of a roller, moment balance could be ignored for the EHL of cylindrical roller. However, it is very important for that of tapered roller. In order to satisfy the moment balance, the position angle of roller would be increased, and large end would be raised. The tiny variation of the position angle would cause severe changes of EHL of tapered roller. The numerical analyses considering moment balance are closer to the real working condition. Meanwhile, the effects are more obvious with the increasing of load, velocity and half-tapered angle.",
        "keywords": [
            "Lubricating performance",
            "Moment balance",
            "Tapered roller"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "Qingdao TechNological University(Qingdao Technological University),Qingdao,China"
            },
            {
                "name": "Xiaoling Liu",
                "org": "Qingdao TechNological University(Qingdao Technological University),Qingdao,China"
            },
            {
                "name": "Peiran Yang",
                "org": "Qingdao TechNological University(Qingdao Technological University),Qingdao,China"
            }
        ],
        "venue": "Nongye Jixie Xuebao/Transactions of the Chinese Society of Agricultural Machinery",
        "year": 2012
    },
    "4AX17ZjT": {
        "id": "4AX17ZjT",
        "title": "General Analysis of Line Contact Elastohydrodynamic Lubrication",
        "abstract": "The isothermal and thermal line contact elastohydrodynamic lubrication with Newtonian and Ree-Eyring models were investigated numerically with the multigrid method and the multi-level multi-integration method.The influence of the slide-roll ratio on the frictional coefficient was analyzed,and the influence of the rheological property and the thermal effect on the viscosity of the oil and the distributions of the pressure,film thickness and temperature with various slide-roll ratios were indicated.The results show that,as the slide-roll ratio increases,the frictional coefficient predicted by the isothermal solutions increases monotonously,whereas the frictional coefficient predicted by the thermal solution first increases and then decreases.Both the thermal and the non-Newtonian shear thinning effects can reduce the effective viscosity of the lubricant,so they affect the frictional coefficient.The existence of thermal effect can reduce the film thickness,and the film thickness predicted by the Newtonian theory is a little smaller than that predicted by the Ree-Eyring theory under the discussed operating conditions,meanwhile,thermal effect can reduce the height of the pressure spike,and the spike obtained by the Ree-Eyring solution is lower than that obtained by the Newtonian solution.Under pure rolling conditions,the film temperature offered by the Ree-Eyring solution is higher than that offered by the Newtonian solution,under the sliding/rolling conditions,however,the later is higher than the former.Furthermore,both the Newtonian and Ree-Eyring solutions indicate that,the film temperature increases as the slide-roll ratio increases.",
        "keywords": [
            "line contact",
            "isothermal and thermal elastohydrodynamic lubrication",
            "Newtonian fluid",
            "Ree-Eyring fluid"
        ],
        "authors": [
            {
                "name": "Yin Changlei",
                "org": "Dept.of Mechanical Engineering,Qingdao Technological University,Qingdao Shandong ,China"
            },
            {
                "name": "Yang Peiran",
                "org": "Dept.of Mechanical Engineering,Qingdao Technological University,Qingdao Shandong ,China"
            },
            {
                "name": "Yang Ping",
                "org": "Dept.of Mechanical Engineering,Qingdao Technological University,Qingdao Shandong ,China"
            }
        ],
        "venue": "Lubrication Engineering",
        "year": 2006
    },
    "F701ZfyN": {
        "id": "F701ZfyN",
        "title": "The Influence of Load Offsetting on the EHL of Tapered Roller",
        "abstract": "Numerical analysis is carried out for elastohydrodynamic lubrication(EHL) of tapered roller considering the moment balance.Under load offsetting condition,the EHL of tapered roller is analyzed,the relation between the load location and the location angle of roller is obtained,and the effects of the corner radius of roller's ends and the velocity parameter on the pressure and film thickness are discussed.The results show that,first,one end of roller can be raised by the load offsetting,so that another end supports the load alone.The lubrication status of the load-carrying end is dangerous because of thinner film thickness and higher pressure,hence partial wear of roller is easy to be found.Second,when the big end supports the load,the EHL is better than that while the small end does;optimal lubrication status of tapered roller,therefore,is that the load moves to a certain place of the big end.Third,with the increasing corner radius of roller's ends and the velocity parameter,the lubrication of tapered roller becomes better.",
        "keywords": [
            "EHL",
            "tapered roller",
            "load offsetting",
            "moment balance"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao ,China"
            },
            {
                "name": "LIU Xiao-ling",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao ,China"
            },
            {
                "name": "YANG Pei-ran",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao ,China"
            }
        ],
        "venue": "Tribology",
        "year": 2012
    },
    "PwumsOZi": {
        "id": "PwumsOZi",
        "title": "Analysis of Thermal Effect and Non-Newtonian Effect Based on Transient Elastohydrodynamic Lubrication",
        "abstract": "For a steel-steel elliptical contact,the responses of the elastohydrodynamic lubrication films to a transient load impulse were investigated numerically,both lubricant rheology and thermal effects were considered.Four groups of solutions were achieved for isothermal Newtonian model,isothermal Ree-Eyring model,thermal Newtonian model,and thermal Ree-Eyring model,respectively.In order to reduce the computing time,a simplified approach for the evaluation of the equivalent shear stress and viscosity of the non-Newtonian lubricant was proposed,and its accuracy was verified by comparing the steady-state thermal solutions without the simplification.Influences of thermal effects and non-Newtonian properties were discussed.The results show that for the present transient EHL problem,the thermal effect is more evident than non-Newtonian effect.",
        "keywords": [
            "equivalent viscosity",
            "thermal effect",
            "elliptical contact",
            "non-Newtonian effect"
        ],
        "authors": [
            {
                "name": "Cui Jinlei",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao Shandong ,China"
            },
            {
                "name": "Yang Ping",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao Shandong ,China"
            },
            {
                "name": "Yang Peiran",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao Shandong ,China"
            }
        ],
        "venue": "Lubrication Engineering",
        "year": 2013
    },
    "KySh4MRS": {
        "id": "KySh4MRS",
        "title": "Investigation of Pure Squeeze Elastohydrodynamic Lubrication On Free Falling and rebounding of the Ellipsoid",
        "abstract": "Numerical analysis was carried out for pure squeeze EHL of free falling ellipsoid. Through reasonable definition about dimensionless parameters of velocity,acceleration and mass,dimensionless form of kinetic equation and dimensional form were unified.Multigrid method of a quarter of domain was used herein for saving time.Numerical results reveal that,in the whole striking process,appearing and changing of the central pressure and edge\u2014peak pressure are analyzed,and when the ellipsoid leaves the oil,these pressures are combined into a high pressure.A dimple of surface is produced by the effect of pure squeeze,and the pressure is distributed in the dimple.In addition the bigger ellipticity ratios,the shorter striking time,the less change of film thickness and the earlier inflection point of the curve.At last,the numerical simulation of the curve of the central pressure against time achieved by Safa and Gohar in their experiment is performed,and the simulation results are close to the test curve,which prove the correctness of the procedure.",
        "keywords": [
            "free falling",
            "ellipsoid",
            "pure squeeze",
            "elasto-hydrodynamic lubrication(EHL)"
        ],
        "authors": [
            {
                "name": "Yang Ping",
                "org": "Qingdao Technological University,Qingdao,Shandong,"
            },
            {
                "name": "Lu Hong",
                "org": "Wuxi Road Machinery Limited Company, Guangxi Liugong Machinery Limited Liability Company,Jiangyin,Jiangsu,"
            },
            {
                "name": "Yang Peiran",
                "org": "Qingdao Technological University,Qingdao,Shandong,"
            }
        ],
        "venue": "China Mechanical Engineering",
        "year": 2013
    },
    "YeRNc04C": {
        "id": "YeRNc04C",
        "title": "The Response of Pure Squeeze EHL Film to the Harmonic Vibration of a Spherical Roller",
        "abstract": "Multi-grid techniques were employed to solve the pure-squeeze elastohydrodynamic lubrication(EHL)problem in elliptic contact between a harmonically vibrating spherical roller and an infinite plane,and a numerical solution was obtained for a typical case.On the basis of this solution,the influence of the balance position,the vibration amplitude and the vibration frequency on the central pressure and central film thickness was analyzed.The results indicate that,in the whole process of squeeze and rebound,the variation curves of the central pressure and central film thickness versus time are very similar to the spatial curves of pressure and film thickness in a steady-state EHL contact.Especially,it was found that the central pressure curve also has a spike in the rebounding stage of the pure-squeeze process due to the disappearance of the central dimple,which results in a very significant local squeeze action in the final period in the rebounding process.The results show also that,as the increase in the balance position,both the time of the effective pure-squeeze action and the height of the main pressure peak are reduced,however,the height of the time-spike is enhanced.Furthermore,as the increases in both the vibration amplitude and frequency,the pure-squeeze action becomes much stronger.",
        "keywords": [
            "variation",
            "pure squeeze",
            "spherical roller",
            "elastohydrodynamic lubrication"
        ],
        "authors": [
            {
                "name": "Xu Hui",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao Shandong ,China"
            },
            {
                "name": "Lu Hong",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao Shandong ,China"
            },
            {
                "name": "Yang Ping",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao Shandong ,China"
            },
            {
                "name": "Yang Peiran",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao Shandong ,China"
            }
        ],
        "venue": "Lubrication Engineering",
        "year": 2011
    },
    "u4PEkGwK": {
        "id": "u4PEkGwK",
        "title": "Analysis of Thermal Effect for EHL of Tapered Roller",
        "abstract": "The thermal elastohydrodynamic lubrication(EHL)of two tapered rollers was investigated.Distributions of the EHL pressure,film thickness and temperatures in the contact were analyzed,and the effects of heat and slide-roll ratio were discussed.It is found from the numerical results that,lubrication performance is reduced by the thermal effect in the EHL of tapered rollers.Along the section of y,geometrical characteristics of the tapered roller can lead to conical shaped distributions of the EHL.The EHL of the middle is better than that of the end due to end leaking,but the differences between the end and the middle are not very large because of the end modification.The lubrication performance becomes worse and worse with the increasing of slide-roll ratio.When the slide-roll ratio is equal to zero,the effect of heat could be ignored.",
        "keywords": [
            "slide-roll ratio",
            "tapered roller",
            "thermal effect",
            "elastohydrodynamic lubrication"
        ],
        "authors": [
            {
                "name": "Yang Ping",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao Shandong ,China"
            },
            {
                "name": "Yang Peiran",
                "org": "School of Mechanical Engineering,Qingdao Technological University,Qingdao Shandong ,China"
            }
        ],
        "venue": "Lubrication Engineering",
        "year": 2011
    },
    "q8qb5lm3": {
        "id": "q8qb5lm3",
        "title": "The Function of the Northwest Countryside NGO from the Perspective of Citizen Participation",
        "abstract": "NGO plays a more and more noticeable role in the northwest countryside with the citizen's orderly participation.The NGO organized the farmers effectively to get involved in the field of economy,politics,culture and public affairs trying to relief the social contradiction,ensure the stability and improvement of politics,enhance the scientific and democratic policy making,strengthen the consciousness and ability of farmers' political participation and enrich the material and cultural life in the rural society.And as a result accelerate the development of the rural society.",
        "keywords": [
            "effect",
            "NGO",
            "northwest countryside",
            "citizen participation"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Gansu Political Science and Law Institute,Gansu,Lanzhou "
            }
        ],
        "venue": "Western Law Review",
        "year": 2008
    },
    "bXmaeJBm": {
        "id": "bXmaeJBm",
        "title": "The Political Participation of Farmers and Herdsmen in the Northwestern Areas \u2014\u2014Based on the Sample Research of Villages",
        "abstract": "The contrast analysis on the general features and differences of farmers' and herdsmen's political participation in Northwestern villages of different ethnic composition shows the following different features of participation.The villages of Han nationality: the strong recognition of formal organization,the deep influence of family clan and farming culture,the leading role of political elite and economic elite,the hidden interest-group competition,the coexistence of institutional and non-institutional participation and varied results of participation;The villages of ethnic minority groups: the strong ethnic identity,the wide-ranging influence of religious organizations and religious figures,the deep influence of ethnic and religious culture,the checks and balances and cooperation between political elite and religious elite,special interest division,the general non-institutional participation,expected results of participation;The villages of multiethnic groups: peaceful coexistence of diverse culture and customs,frequent ethnic contact,special role played by Han nationality,a clear ethnic interests division and village democracy,strong institutional participation,balanced outcome of participation due to the multiethnic composition.",
        "keywords": [
            "political participation",
            "the village of ethnic minority group",
            "the village of Han nationality",
            "the village of multiethnic groups",
            "farmer and herdsman"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Gansu Political Science and Law Institute,Lanzhou ,China"
            }
        ],
        "venue": "Science Economy Society",
        "year": 2012
    },
    "iOqp5zaY": {
        "id": "iOqp5zaY",
        "title": "The Customary Law in the Northwest Minority Areas from the Perspective of Modernization",
        "abstract": "In the process of China's modernization,the situation of unbalanced development between developed and developing areas has been formed objectively.The Northwest ethnic minority areas lag far behind in many aspects.And differences on law application do exist between people from different nationalities and regions.Customary law playing an important role to a great extent is a case in point.Due to a certain conflict between northwest minority customary law and state law,we should adhere to modernization of legal system,treat minority customary law rationally,integrate the beneficial local resources in the northwest minority customary law in order to create a good environment for the modern legal system and achieve state law and customary law interaction.",
        "keywords": [
            "customary law",
            "ethnic minorities",
            "modernization"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Gansu Political Science and Law Institute,Lanzhou ,China"
            }
        ],
        "venue": "Science Economy Society",
        "year": 2011
    },
    "SMnb2sNc": {
        "id": "SMnb2sNc",
        "title": "The General Review on Chinese Customary Law of Ethnic Minorities over the Last Ten Years",
        "abstract": "In the last 10 years,the research on customary law of ethnic minorities focuses on the following aspects: the basic theory,the content,the effect and function,the dispute resolution mechanism,the ethnic culture and the relationship between the national law and customary law.In the future more attention should be paid to the empirical study.At the same time,it is necessary to explore the data on customary law of ethnic minorities with weak research basis,deepen the comparative study and strengthen the study on the customary law of northwest ethnic minority.",
        "keywords": [
            "ethnic minority",
            "customary law",
            "general review"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Gansu Political Science and Law Institute,Lanzhou ,China"
            }
        ],
        "venue": "Journal of Lanzhou Jiaotong University",
        "year": 2013
    },
    "UP0GSJ49": {
        "id": "UP0GSJ49",
        "title": "A Study on the Judicial Remedy of the Rights of Villager's Self-Governance",
        "abstract": "The infringement of rights in the process of villager's self-governance has been a widespread problem and brought about the harmful consequences in our country.At the same time the non-judicial remedy of rights contains lots of serious flaws.Therefore,it is very important to construct the judicial remedy system of rights in the process of villager's self-governance so as to ensure the realization of various rights,avoid the power abuse,enhance the awareness of the law,and foster the law-abiding habit.",
        "keywords": [
            "rights",
            "villager's self-governance",
            "judicial remedy"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Gansu Political Science and Law Institute,Lanzhou "
            }
        ],
        "venue": "Journal of Gansu Political Science and Law Institute",
        "year": 2007
    },
    "aeHwJMPo": {
        "id": "aeHwJMPo",
        "title": "Comparative Study of the Civil Society Theories of Hegel,Marx and Gramsci",
        "abstract": "Hegel,for the first time,studied the civil society as independent from the political state and,while conferring upon it economic connotations,believed that the civil society,determined by the political state as it should be,is transcended by the political state.Marx believed that the civil state is more of an economic nature and the basis of political state,and that the liberation of the humanity alone may lead to the transcendence of the civil society. Gramsci believed that the civil society is a notion that belongs to the realm of superstructure and that the political state will sustain itself only if it is built upon the basis of the civil society.",
        "keywords": [
            "political state",
            "Marx",
            "civil society",
            "Antonio Gramsci",
            "Hegel"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": ""
            }
        ],
        "venue": "Journal of Lanzhou University(Social Sciences)",
        "year": 2007
    },
    "0XIlSyVB": {
        "id": "0XIlSyVB",
        "title": "Problems and Their Countermeasures of the Northwest Countryside NGO from the Perspective of Citizen Participation",
        "abstract": "Due to heavy dependence on the government,its own weak points and low-level standard,the northwest countryside NGO develops slowly and unbalancedly,which affects the level of the citizen's participation in the development of rural areas.Hence,it is essential to improve the relative laws and regulations,create an atmosphere in the rural area favorable for healthy development of the NGO,promote the self-construction,strengthen the supervision and the guide of government and set up the farmer association gradually so as to enhance the NGO's overall strength to encourage the citizen's participation.",
        "keywords": [
            "NGO",
            "northwest countryside",
            "problem",
            "countermeasure",
            "citizen participation"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Gansu Institute of Political Science and Law,Lanzhou ,China"
            }
        ],
        "venue": "Journal of Lanzhou Jiaotong University",
        "year": 2008
    },
    "YA5AUpHl": {
        "id": "YA5AUpHl",
        "title": "Hu Jingtao's Ideology of Citizens' Politic Participation",
        "abstract": "Hu Jingtao's ideology of citizens' politic participation is the same with that of Marxist revolutionary teachers and the different leading generations of the CPC.Hu Jingtao thinks that people's democracy is soul of socialism.We should broadly persuade people to join in the management of public affairs.He thinks citizens' participation should be in line with the reform of politic system.We should strengthen participating degree for the citizens in joining in public policy-making,and make full use of democratic parties and social associations in citizens' politic participation.We should enlarge the orderly politic participation by putting forward basic democracy and guarantee ordinary Party members' politic participation by putting forward democracy inside the Party.Hu Jingtao's ideology of citizens' politic participation is the focusing reflection of the new achievement from Marxist theory of political participation.",
        "keywords": [
            "citizen",
            "politic participation",
            "Hu Jingtao"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Gansu Institute of Political Science and Law,Lanzhou ,Gansu,China"
            }
        ],
        "venue": "Journal of Jianghan University(Social Science Edition)",
        "year": 2012
    },
    "d4nyk4Qr": {
        "id": "d4nyk4Qr",
        "title": "Social Management Innovation and Constitutional Spirit",
        "abstract": "Social management innovation has characteristics of service,cooperation among government,NGO and citizens,social autonomy,and rule of law,whose pursuit of value is quite similar to constitutional spirit,such as human rights,democracy,rule of law,government limitation.This paper believes social management innovation should be guided by constitutional spirit,consistently improve leadership of party on social management,enhance government function of public service and cooperation capability,and enlarge citizens' participation.",
        "keywords": [
            "human rights",
            "social management",
            "social management innovation",
            "rule of law",
            "democracy"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Administrative Department,Gansu Political Science and Law Institute,Lanzhou,Gansu,,PRC"
            }
        ],
        "venue": "Journal of Northwest Normal University(Social Sciences)",
        "year": 2012
    },
    "e93nI92H": {
        "id": "e93nI92H",
        "title": "Scientific Government Performance Evaluation and the Protection of Citizens' Rights",
        "abstract": "The basic value orientation of government performance adopted by democratic state is to protect the citizens' rights and the level of government performance affects the realization of the citizens' rights.In order to better protect the citizens' rights,our government should implement a scientific outlook on development;foster sound views on political achievement;take the protection of citizens' rights as the value orientation of government performance evaluation;institute scientific government performance evaluation system in which the protection of citizens' rights should be included and strengthened;realize the government performance evaluation from various sources,expanding citizens' participation;transform the government functions to exercise fully the function of government in protecting citizens' rights and raise its level of safeguarding citizens' rights.",
        "keywords": [
            "protection of citizens' rights",
            "scientific outlook on development",
            "government performance evaluation"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "School of Administration,Gansu Political Science and Law Institute,Lanzhou ,China"
            }
        ],
        "venue": "Journal of Lanzhou Jiaotong University",
        "year": 2010
    },
    "COSze6if": {
        "id": "COSze6if",
        "title": "Fundamental Features of Human Right Philosophy in Marxism",
        "abstract": "Marxism Human right philosophy plays an important role in the theory of Marxism and its fundamental features are reflected in the following four aspects: the scientific feature of human right origin,the authenticity of its attribute,the integrality of its content and the practical feature of its development.",
        "keywords": [
            "human right philosophy",
            "features",
            "Marxism"
        ],
        "authors": [
            {
                "name": "Yang Ping",
                "org": "School of Administration,Gansu Institute of Political Science and Law,Lanzhou ,China"
            }
        ],
        "venue": "Lanzhou Jiaotong University",
        "year": 2005
    },
    "pEIll9Bx": {
        "id": "pEIll9Bx",
        "title": "Farmer Participation in Politics in Northwestern China's Rural Areas",
        "abstract": "Farmer participation in the local politics is of great significance in the fields of state security,social stability, economic development and citizenship fostering,and a systematic nurturing of this kind of participation must be guided by principles such as realistic consideration of the farmers' abilities,feasibility of participation,intrinsic motivation and guarantee of stability.The government,on the other hand,also needs to provide adequate facilities for such participation.",
        "keywords": [
            "modernization",
            "farmer",
            "northwestern China's rural area",
            "political participation"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "School of Administration,Gansu Institute of Political Science and Law,Lanzhou ,China"
            }
        ],
        "venue": "Journal of Lanzhou University(Social Sciences)",
        "year": 2011
    },
    "6KcE7TDA": {
        "id": "6KcE7TDA",
        "title": "Study of Alternative Dispute Resolution in Ethnic Areas Based on Perspective of Customary Law",
        "abstract": "Modern system of judicial proceedings has some limitations,so establishing alternative dispute resolution is very necessary in minority areas.The alternative dispute resolution including using minority customary law has its own characteristics and advantages in minority areas.It has very positive significance to use and integrate alternative dispute resolution in minority areas and to achieve minority customary law and state law complementing each other.",
        "keywords": [
            "minority customary law",
            "alternative dispute resolution",
            "minority areas"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "School of Law,Gansu Institute of Political Science and Law,Lanzhou ,China"
            }
        ],
        "venue": "Journal of Lanzhou Jiaotong University",
        "year": 2011
    },
    "XBs2tXbP": {
        "id": "XBs2tXbP",
        "title": "Recovery of Energy Sources from Wastewater",
        "abstract": "Three main approaches to the recovery of biomass energy sources,i.e,biogas,hydrogen and electricity,from wastewater simultaneously with the treatment of wastewater using microbes are briefly reviewed including their fundamentals. In this paper,recent advances in methanogenic anaerobic digestion,biological hydrogen production and microbial fuel cells (MFCs)are introduced with the outlook of future development linked with municipal and industrial wastewater treatment,as well as relevant sludge treatment and disposals.",
        "keywords": [
            "biological hydrogen production",
            "wastewater",
            "methanogenic anaerobic digestion",
            "microbial fuel cell(MFC)",
            "energy recovery"
        ],
        "authors": [
            {
                "name": "LIU Yang",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Environmental Science & Technology",
        "year": 2010
    },
    "frfs8kbJ": {
        "id": "frfs8kbJ",
        "title": "Treatment of ABS resin manufacturing wastewater by biological activated carbon(BAC)",
        "abstract": "Wastewater from ABS condensation drying section was treated by biological activated carbon (BAC) and activated carbon without bacteria. The bioregeneration occurring during simultaneous adsorption-biodegradation processes was studied seriously. The organic nitriles and aromatic compounds could be decomposed and transformed, and the removal efficiencies of COD, TOC and Org-N were all more than 80%. The organic nitrogen of ABS wastewater could be transformed into NH 3-N, and its transformation efficiency was more than 65%. There were a large number of microorganisms on the surface of activated carbon in the BAC, such as long-stem bacteria, vorticella and coccises. The activated carbon provided an attachment surface for microorganisms and protected them from shock loadings of toxic and inhibitory materials, whereas microorganisms bioregenerated the activated carbon.",
        "keywords": [
            "ABS resin wastewater",
            "Activated carbon adsorption",
            "Aromatic compouds",
            "Biological activated carbon",
            "Organic nitriles"
        ],
        "authors": [
            {
                "name": "Bo Lai",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "ZHOU Yue-xi",
                "org": "Chinese Research Academy of Environmental Sciences(Chinese Research Academy of Environmental Sciences),Beijing,China"
            },
            {
                "name": "Ping Yang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Zhongguo Huanjing Kexue/China Environmental Science",
        "year": 2012
    },
    "RSwEhFEN": {
        "id": "RSwEhFEN",
        "title": "Engineering application of internal circulation integrated MBR with particle carriers in chemical industry wastewater treatment",
        "abstract": "In order to investigate the treatment efficiency of integrated MBR for chemical industry wastewater, an 80 m3/d full-scale internal circulation integrated MBR with particle carriers was designed and used to treat chemical industry wastewater for about one hundred days. The results showed that when the influent concentrations of CODCr, NH3-N and TP were 153.20-594.68 mg\u00b7L-1, 2.02-23.79 mg\u00b7L-1 and 3.36-13 mg\u00b7L-1, respectively, the water quanlity of effluent was stable after 90 days' operation performance, and the effluent concentrations of CODCr, NH3-N and TP were lower than 50 mg\u00b7L-1, 3 mg\u00b7L-1 and 1 mg\u00b7L-1, and the removals were 80.25%-87.15%, 73.32%-99.78% and 87.09%-93.82%, respectively. The pH value of the effluent was within 6.79-7.83. The effluent was clear and without stimulated smell. The treatment efficiency of membrane bioreactor was improved by adding particle carriers, which continuously scoured and collidded membrane surface, resulting in alleviating membrane fouling.",
        "keywords": [
            "Aerobic",
            "Anoxic",
            "Internal circulation",
            "Membrane bioreactor (MBR)",
            "Particle carriers"
        ],
        "authors": [
            {
                "name": "HUANG Jian-sheng",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yong Guo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "TAN Xian-dong",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Ping Yang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Sichuan Daxue Xuebao (Gongcheng Kexue Ban)/Journal of Sichuan University (Engineering Science Edition)",
        "year": 2009
    },
    "K8UjaKve": {
        "id": "K8UjaKve",
        "title": "THE STUDY ON THE TREATMENT OF POLYPHENYLENE SULFIDE WASTEWATER BY A/O-MBR",
        "abstract": "A/O membrane bioreactor was used to treat wastewater of PPS production,The results showed that when treated the raw PPS wastewater,the COD removal rate of system was impacted,the average removal rate was 91%.Ammonia nitrogen removal rate was low.Then the system was more stable to treat anaerobic effluent of PPS wastewater treatment,the concentration of effluent COD remained under 69 mg/L,Average concentration was 27 mg/L.Average removal rate was 97%.The total nitrogen of effluent was effected by the value of m(COD)/m(TN),the removal rate in the range of 38%\uff5e55%,The pH of the effluent was in 7.59\uff5e7.92.SS remained under 5 mg/L and the color was 16 times.The treatment wastewater can be reused through the combination of membrane cleaning can effectively recovery the new film membrane specific flux.The results provided a new idea for efficient treatment and reuse of PPS wastewater.",
        "keywords": [
            "membrane fouling",
            "reuse",
            "MBR",
            "PPS wastewater"
        ],
        "authors": [
            {
                "name": "Shi Jindou",
                "org": "School of Architecture and Environment,Sichuan University"
            },
            {
                "name": "Su Ti",
                "org": "Chengdu Engineering Co.Ltd.,of China Light Industry: Chengdu,China"
            },
            {
                "name": "Zhou Jianding",
                "org": "School of Architecture and Environment,Sichuan University"
            },
            {
                "name": "Yang Ping",
                "org": "School of Architecture and Environment,Sichuan University"
            }
        ],
        "venue": "Technology of Water Treatment",
        "year": 2012
    },
    "IcBoBkQR": {
        "id": "IcBoBkQR",
        "title": "APPLICATION OF HYDROLYTIC ACIDIFICATION +SBR TECHNOLOGY IN THE SLAUGHERHOUSE WASTEWATER TREATMENT",
        "abstract": "The slaugherhouse wastewater was treated with hydrolytic acidification + SBR technology. The operatiomal results proved that various fouling indexes practically determined reached the first class discharge standerd of water pollutants for meat packing industry ( GB13457-92) . The technology has good effectiveness. It is able to be used in slaugherhouse wastewater treatment widely.",
        "keywords": [
            "SBR",
            "hydrolytic acidification",
            "slaugherhouse wastewater"
        ],
        "authors": [
            {
                "name": "Guo Ting",
                "org": "College of architecture and environment, Sichuan University, Chengdu , China"
            },
            {
                "name": "Xie Yudan",
                "org": " Sichuan Hexiang Environmental Engineering Co. Ltd., Chengdu , China"
            },
            {
                "name": "Yang Ping",
                "org": "College of architecture and environment, Sichuan University, Chengdu , China"
            }
        ],
        "venue": "Technology of Water Treatment",
        "year": 2009
    },
    "WzTf1rVI": {
        "id": "WzTf1rVI",
        "title": "The Characteristics of Particle Biofilm Sequencing Batch MBR for Wastewater Treatment",
        "abstract": "A sequencing batch membrane bioreactor with polymer microcarriers was introduced to treat synthetic organic wastewater and industrial wastewater containing toluene and xylene.The removal effect of pollutants and the influence factors of membrane fouling were observed.The results showed that when the synthetic organic wastewater with the influent COD concentration of 218~1003 mg/L and NH3-N concentration of 24~96 mg/Lwas treated,the removal rates of COD and NH3-N were 87%~99% and 65%~99%,respectively;when industrial wastewater with the influent COD concentration of 174~709 mg/L and NH3-N concentration of 18~63 mg/L was treated,the removal rates of COD and NH3-N were 60%~96% and 72%~94%,respectively.It was found that,there was not significant membrane fouling when the MLSS concentration was under 19.28 g/L after polymer microcarriers were put into the MBR.Continuous suction impelled faster growth of transmembrane pressure difference,which accelerated membrane pollution.The operations of sequencing batch MBR with polymer microcarriers were studied,which provided the basis for practical application of this new pattern MBR.",
        "keywords": [
            "Membrane bioreactor",
            "Membrane flux",
            "Membrane fouling",
            "Wastewater treatment"
        ],
        "authors": [
            {
                "name": "GUO Yong",
                "org": "School of Architecture and Environmental,Sichuan Univ.,Chengdu ,China"
            },
            {
                "name": "LI Li",
                "org": "School of Architecture and Environmental,Sichuan Univ.,Chengdu ,China"
            },
            {
                "name": "CHEN Wen-qing",
                "org": "School of Architecture and Environmental,Sichuan Univ.,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Architecture and Environmental,Sichuan Univ.,Chengdu ,China"
            }
        ],
        "venue": "Journal of Sichuan University(Engineering Science Edition)",
        "year": 2008
    },
    "7ZSUoPuz": {
        "id": "7ZSUoPuz",
        "title": "Advanced Treatment Technology of Coking Wastewater and Its Reuse",
        "abstract": "Coking wastewater is needed for advanced treatment after biological treatment to reuse.It reviewed major advanced treatment technology of coking wastewater in the country,including physical methods and advanced oxidation,and introduced the reuse of treated wastewater.It provided a reference value for the treatment and reuse of coking wastewater.",
        "keywords": [
            "advanced treatment technology",
            "reuse",
            "coking wastewater"
        ],
        "authors": [
            {
                "name": "Xiao Rongrong",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Jiang Chuanchun",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Yang Haojie",
                "org": "Guangzhou EP Engineering Design Institute Co.,Ltd,Guangzhou ,China"
            },
            {
                "name": "Yang Ping",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Sichuan Chemical Industry",
        "year": 2010
    },
    "b8TQuNzC": {
        "id": "b8TQuNzC",
        "title": "Model of organics degradation and electricity generation in AFB-MFC system",
        "abstract": "In order to find out the relationship between electricity generation and organics degradation in anaerobic fluidized bed microbial fuel cell, the model of organics degradation based on mass balance and biomass growth was developed. The model of electricity generation based on inflow, external resistance and substrate concentration of influence was also developed. The parameters of the two models were estimated and validated using experimental data obtained in an anaerobic fluidized bed microbial fuel cell used to treat high-strength organic wastewater. The model of organics degradation is q=0.607S/398.82+S and the model of electricity generation is U=96485S/8 middot; Q\u00b7(6\u00d710-6S-0.0133)\u00b7Rex.",
        "keywords": [
            "Anaerobic fluidized bed",
            "Degradation",
            "Electricity generation",
            "Microbial fuel cell",
            "Organics"
        ],
        "authors": [
            {
                "name": "HUANG Jian-sheng",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Ping Yang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yong Guo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Sichuan Daxue Xuebao (Gongcheng Kexue Ban)/Journal of Sichuan University (Engineering Science Edition)",
        "year": 2011
    },
    "hk1vRcsi": {
        "id": "hk1vRcsi",
        "title": "Performance of intermittent aeration moving bed biofilm reactor in depth processing nitrogenous wastewater",
        "abstract": "Effects of organic loading and aeration mode on pollutants removal performance of the Intermittent aeration moving bed biofilm reactor(IAMBBR) in treating nitrogenous wastewater was studied experimentally. The results indicated that average removal efficiencies of COD, ammonium and TN are 95.88%, 92.22% and 76.73% with influent COD, ammonium and NO3 --N concentration of 720, 20 and 100 mg/L, respectively, when the IAMBBR is operated with HRT of 12 h, temperature of (25\u00b12) \u00b0C, pH of 6~9, organic loading of 1.44 kg COD/(m3\u00b7d) and circulating aeration of 2 h aeration and 4 h stop aeration. And better organic pollutants and nitrogen removal performance could be achieved in single reactor. Meanwhile, operation mode of the IAMBBR has significant influence on biofilm morphology adhering to suspended carriers.",
        "keywords": [
            "Aeration mode",
            "Depth processing",
            "Intermittent aeration moving bed biofilm reactor",
            "Organic loading"
        ],
        "authors": [
            {
                "name": "PENG Yu-mei",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "LI Hui-qiang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Ping Yang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Bo Lai",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "LI Yuan-qin",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Sichuan Daxue Xuebao (Gongcheng Kexue Ban)/Journal of Sichuan University (Engineering Science Edition)",
        "year": 2013
    },
    "Ip7Y1wKl": {
        "id": "Ip7Y1wKl",
        "title": "A/O MBR performance in treating a wastewater of high ammonia concentration",
        "abstract": "Series of experiments were conducted to determine the effects of C/N ratio and effluent recyling on nitrification and denitrification in an anoxic/aerobic membrane bioreactor employed for treating a wastewater of high NH+4-N concentration. At a recycle ratio of 2 and C/N of 6, COD, NH+4-N and TN removal rates were 96.17%, 97.76%, 76.29% respectively. During the period of treatment performance, the NH+4-N removal was proportional to its volumetric loading. When MLSS was 9-13 g/L, COD in the supernatant was relatively low, and the pressure drop across the membrane increased slowly.",
        "keywords": [
            "membrane fouling",
            "nitrogen removal",
            "high concentration NH+4-N wastewater",
            "anoxic/aerobic membrane bioreactor"
        ],
        "authors": [
            {
                "name": "Zhang Shuang",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu Sichuan "
            },
            {
                "name": "Song Jingguo",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu Sichuan "
            },
            {
                "name": "Yang Ping",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu Sichuan "
            },
            {
                "name": "Hou Linglong",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu Sichuan "
            },
            {
                "name": "Chen Wenqing",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu Sichuan ;SCU-HITACHI Environment Applied Technology Research Center,Chengdu Sichuan "
            }
        ],
        "venue": "Environmental Pollution & Control",
        "year": 2009
    },
    "5dcUMyvB": {
        "id": "5dcUMyvB",
        "title": "Removal of FePO4 and Fe3(PO4)2 crystals on the surface of passive fillers in Fe0/GAC reactor using the acclimated bacteria.",
        "abstract": "As past studies presented, there is obvious defect that the fillers in the Fe(0)/GAC reactor begin to be passive after about 60 d continuous running, although the complicated, toxic and refractory ABS resin wastewater can be pretreated efficiently by the Fe(0)/GAC reactor. During the process, the Fe(3)(PO(4))(2) and FePO(4) crystals with high density in the passive film are formed by the reaction between PO(4)(3-) and Fe(2+)/Fe(3+). Meanwhile, they obstruct the formation of macroscopic galvanic cells between Fe(0) and GAC, which will lower the wastewater treatment efficiency of Fe(0)/GAC reactor. In this study, in order to remove the Fe(3)(PO(4))(2) and FePO(4) crystals on the surface of the passive fillers, the bacteria were acclimated in the passive Fe(0)/GAC reactor. According to the results, it can be concluded that the Fe(3)(PO(4))(2) and FePO(4) crystals with high density in the passive film could be decomposed or removed by the joint action between the typical propionic acid type fermentation bacteria and sulfate reducing bacteria (SRB), whereas the PO(4)(3-) ions from the decomposition of the Fe(3)(PO(4))(2) and FePO(4) crystals were released into aqueous solution which would be discharged from the passive Fe(0)/GAC reactor. Furthermore, the remained FeS and sulfur (S) in the passive film also can be decomposed or removed easily by the oxidation of the sulfur-oxidizing bacteria. This study provides some theoretical references for the further study of a cost-effective bio-regeneration technology to solve the passive problems of the fillers in the zero-valent iron (ZVI) or Fe(0)/GAC reactor.",
        "keywords": [],
        "authors": [
            {
                "name": "Bo Lai",
                "org": "Department of Environmental Science and Engineering, School of Architecture and Environment, Sichuan University, Chengdu 610065, China. laibo1981@163.com"
            },
            {
                "name": "Yuexi Zhou",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Juling Wang",
                "org": ""
            },
            {
                "name": "Jinghui Yang",
                "org": ""
            },
            {
                "name": "Huiqiang Li",
                "org": ""
            }
        ],
        "venue": "Journal of hazardous materials",
        "year": 2012
    },
    "BwjnEoaA": {
        "id": "BwjnEoaA",
        "title": "THE ADVANCED TREATMENT OF FIBERGLASS WASTEWATER BY MEMBRANE BIOREACTOR",
        "abstract": "A trial of using submerged membrane coupled fluidized bed bioreactor with porous polymeric carrier for advanced treatment of secondary effluent from a fiberglass sewage treatment plant was studied.The results showed that:under the condition that,the concentration of influent COD was 131.5~156.8 mg/L,the turbidity was 8.46~18.57NTU,the concentration of COD in the effluent water from MBR system was about 55 mg/L,the turbidity was less than 1NTU,and the removal rates of COD and turbidity were above 60% and 90% respectively.In order to obtain the good removal effect for COD,the volumetric loading of influent COD was 0.35~0.4 kg/(m3\u00b7d).In addition,the effect of mitigating membrane fouling by adding porous polymeric carrier was discussed.The effluent of MBR system can't be reused for producing directly,and should be treated by reverse osmosis system.",
        "keywords": [
            "fiberglass sewage",
            "advanced treatment",
            "porous carrier",
            "membrane bioreactor"
        ],
        "authors": [
            {
                "name": "Yang Haojie",
                "org": " College of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "L\u00fc Kunshan",
                "org": " College of Architecture and Environment,Sichuan University,Chengdu ,China; Jushi Group Chengdu Co.,Ltd,Chengdu ,China"
            },
            {
                "name": "Guo Yong",
                "org": " College of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Li Jiucheng",
                "org": " College of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Yang Ping",
                "org": " College of Architecture and Environment,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Environmental Engineering",
        "year": 2009
    },
    "X8ktF9vu": {
        "id": "X8ktF9vu",
        "title": "Simultaneous biological removal of nitrogen and sulfur by denitrification in anaerobic-aerobic integrated reactors",
        "abstract": "Anaerobic-aerobic integrated reactors were used to treat wastewater containing nitrogen and sulfide.The effect of C/NH+4-N and S/N(NO-3-N and NO-2-N)on simultaneous biological removal of nitrogen and sulfur was studied.The results show that simultaneous removal of sulfide,nitrogen and COD as well as elemental sulfur accumulation could be achieved under mixotrophic conditions.It was shown that an increase of sulfide concentration showed little inhibition of COD removal rate and denitrification in the anaerobic area.The NH+4-N removal effect was promoted when the sulfide concentration was less than 4.6 mmol\u00b7L-1.A 20%\uff5e75% S0 production rate was achieved when S/N was 0.2\uff5e1.7.The decrease of C/NH+4-N had no obvious effect on denitrification,but it promoted sulfide removal.The X-ray diffraction result indicates that the product from the anaerobic area is elemental sulfur.In the aerobic area,the increase of sulfide concentration had no obvious influence on COD removal,while it inhibited the nitrification process remarkably at sulfide concentrations more than 15 mg\u00b7L-1.",
        "keywords": [
            "Anaerobic-aerobic fluidized bed of integrated reactor",
            "Elemental sulfur",
            "Simultaneous desulfidation and denitrogenation process"
        ],
        "authors": [
            {
                "name": "ZHU Mei",
                "org": "College of Architecture & Environment,Sichuan University,Chengdu 2.Sichuan Academy of Environmental Sciences,Chengdu "
            },
            {
                "name": "YANG Ping",
                "org": "College of Architecture & Environment,Sichuan University,Chengdu 2.Sichuan Academy of Environmental Sciences,Chengdu "
            },
            {
                "name": "GUO Yong",
                "org": "College of Architecture & Environment,Sichuan University,Chengdu 2.Sichuan Academy of Environmental Sciences,Chengdu "
            },
            {
                "name": "ZHENG Dehui",
                "org": "College of Architecture & Environment,Sichuan University,Chengdu 2.Sichuan Academy of Environmental Sciences,Chengdu "
            }
        ],
        "venue": "Acta Scientiae Circumstantiae",
        "year": 2008
    },
    "InY9wI7C": {
        "id": "InY9wI7C",
        "title": "Study on performance of domestic wastewater treatment by novel rotating-cage bioreactor with carriers of multi-surface hollow balls",
        "abstract": "Rotating biological contactor is an efficient biofilm wastewater treatment technology.A rotating-cage bioreactor was designed as the improvement of rotating biological contactor.Multi-surface hollow balls as biomass carriers were added in the cage,and the performance of this reactor for domestic wastewater treatment was researched.Controlling the rotary speed at 9~12 r/min,when the influent concentrations of COD,NH3-N and TN were 215.9\uff5e241.0 mg/L,22.1\uff5e24.0 mg/L and 30.3\uff5e33.9 mg/L,the removal rates were 85.0%\uff5e90.2%,80.0%\uff5e98.3% and 21.3%\uff5e34.2%,respectively,during the shortening of HRT from 10 h to 4.5 h.The result showed that this novel rotating-cage bioreactor was feasible for domestic wastewater treatment,and the experimental data can provide suitable techniques for efficient treatment of rural domestic wastewater.",
        "keywords": [
            "multi-surface hollow ball",
            "biological nitrification",
            "domestic wastewater",
            "rotating-cage bioreactor"
        ],
        "authors": [
            {
                "name": "Li Yuanqin",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Tang Yi",
                "org": "China National Heavy Machinery Research Institute Ltd.Chengdu Branch,Chengdu ,China"
            },
            {
                "name": "Liang Jin",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Yang Ping",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Chinese Journal of Environmental Engineering",
        "year": 2012
    },
    "UQm3LlRL": {
        "id": "UQm3LlRL",
        "title": "Study on Treatment of Wastewater from Livestock and Poultry Farms",
        "abstract": "The features of the wastewater from livestock and poultry farms such as high contents of organic matters and ammonia nitrogen and good biodegradability,as well as the pollution situation were introduced.The progresses of treatment technologies of the wastewater home and abroad in recent years including physic-chemical process and biological process were reviewed.With analysis of advantages and disadvantages of the present process,it was proposed that a combined process of anaerobic/anoxic-aerobic process is the main process to treat wastewater from large scale livestock and poultry farms.It was suggested that the waste management in animal farms should consider two aspects,prevention and treatment.",
        "keywords": [
            "wastewater treatment",
            "anaerobic process",
            "aerobic process",
            "Livestock and poultry wastewater"
        ],
        "authors": [
            {
                "name": "LIANG Jin",
                "org": "College of Architecture & Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "LI Yuan-qin",
                "org": "College of Architecture & Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Architecture & Environment,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Sichuan Environment",
        "year": 2011
    },
    "gatuwOPB": {
        "id": "gatuwOPB",
        "title": "Study on property of microbial fuel cell with porous spherodial particles",
        "abstract": "A typical two-chamber microbial fuel cell was designed in the experiment.When adding porous spherodial particle into the anodic chamber,the influence on the property of power generation of man-made wastewater was obviously.During the experiment,when adding spherodial particle,the maximum voltage could be enhanced from 253 mV to 280 mV,the time of continuous power output generation changed from 5.5 d to 8 d,the removal rate of COD increased from 78% to 82.6%.When porous spherodial particle was added into the anodic chamber,the system internal resistance decreased from 286 \u03a9 to 199.4 \u03a9,and the maximum power density changed from 78.6 mW/m2 to 114.3 mW/m2.The result indicated that microorganism was prone to cling and grow on the surface of porous spherodial particle.Through even mixing,the particles collided continuously on the anode,it was good for the extracellular electron transfer to the anode.In this process,the anodic internal resistance decreased,the output voltage generation was promoted,the maximum output power could be promoted,and so,the electrogenesis capacity was prominent improved.",
        "keywords": [
            "power generation",
            "wastewater treatment",
            "porous spherodial particle",
            "microbial fuel cell"
        ],
        "authors": [
            {
                "name": "Wang Hui",
                "org": "School of Architecture & Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Yang Ping",
                "org": "School of Architecture & Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Guo Yong",
                "org": "School of Architecture & Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Liao Xun",
                "org": "School of Architecture & Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Li Xiaofang",
                "org": "School of Architecture & Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Wang Li",
                "org": "School of Architecture & Environment,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Chinese Journal of Environmental Engineering",
        "year": 2010
    },
    "2UBD28Xu": {
        "id": "2UBD28Xu",
        "title": "Start-up of a Continuous Flow MFC and Bio-Particles Formation",
        "abstract": "To aim at the chemical energy recovery from organics contained in wastewater and the improvement of the COD removal efficiency of microbial fuel cell (MFC),a new type MFC,i.e.anaerobic fluidized bed microbial fuel cell (AFB-MFC),was designed and to be used for the wastewater treatment to produce electricity.The start-up of the AFB-MFC system and the formation of bio-particles in anode chamber of the MFC were studied.The electricity production performance and the wastewater treatment of the AFB-MFC system were examined during the start-up period.Moreover,the effect of external resistance on electricity production was studied too.The results show that,with certain experimental conditions,the AFB-MFC reactor can successfully start-up in 36 days and the mixed bio-particles are formed too.During the whole start-up period,the voltage generated by AFB-MFC in feed-batch mode is higher than that in continuous mode,and the highest voltage generated by AFB-MFC in feed-batch mode is 850 mV.When the AFB-MFC is operated in continuous mode,the voltage decreases to 680\uff5e690 mV,and finally becomes stable.The COD removal efficiency increases with the increase of influent volume loading rate,and when the AFB-MFC is successfully start-up and operated in continuous mode,the COD removal efficiency can be 80.00%\uff5e90.41%.When external resistance is 100\u03a9,the AFB-MFC has the best electricity production performance,and its power density can reach the highest value of 21.89 mW\u00b7m-2.",
        "keywords": [
            "voltage",
            "COD removal efficiency",
            "bio-particles",
            "start-up",
            "microbial fuel cell",
            "continuous-flow"
        ],
        "authors": [
            {
                "name": "HUANG Jian-sheng",
                "org": "School of Architecture and Environmental,Sichuan University,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Architecture and Environmental,Sichuan University,Chengdu ,China"
            },
            {
                "name": "GUO Yong",
                "org": "School of Chemical Engineering,Sichuan University,Chengdu ,China"
            },
            {
                "name": "LI Xiao-fang",
                "org": "School of Architecture and Environmental,Sichuan University,Chengdu ,China"
            },
            {
                "name": "LUO Min",
                "org": "Chongqing River Engineering Consultation Center CO.LTD,Chongqing ,China"
            }
        ],
        "venue": "Journal of Chemical Engineering of Chinese Universities",
        "year": 2010
    },
    "KkqzweE5": {
        "id": "KkqzweE5",
        "title": "A Brief Analysis of the Decentralized Sewage Treatment of Domestic Wastewater in Villages and Small Towns",
        "abstract": "This paper introduced the basic concepts and classification of decentralized sewage treatment,discussed the characteristic of different pollution treatment technologies and compared their advantages and disadvantages.Some representative decentralized sewage treatments which are widely used in some foreign countries are enumerated,combined with our national conditions,the combination process of natural treatment and strengthened purification is put forward to treatment the domestic sewage in small towns and villages which are rich in land resources and highly developed.",
        "keywords": [
            "strengthened purification",
            "decentralized sewage treatment",
            "natural treatment systems",
            "Domestic wastewater"
        ],
        "authors": [
            {
                "name": "WU Xin-yue",
                "org": "College of Architecture & Environmental Engineering,Sichuan University,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Architecture & Environmental Engineering,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Sichuan Environment",
        "year": 2013
    },
    "m0cbK5oj": {
        "id": "m0cbK5oj",
        "title": "Study on Removal of COD and NH_3-N in Domestic Sewage by Novel Rotating Biological Contactor with Carrier of Granular Active Carbon",
        "abstract": "The improved rotating biological contactor was developed to treat the domestic sewage.The disks were changed as a rotating cage,in which granular active carbon were added as carriers.The results showed that in the conditions that the rotary speed was 15rpm,HRT were 10,8,6 and 4.5 respectively,average influent COD was 223mg/L,the average effluent COD were 15.6,17.9,23.4 and 28.2mg/L respectively,the average removal rates of COD were 93.0%,91.9%,89.5% and 86.6% respectively;the average influent NH3-N was about 22mg/L,the average effluent NH3-N were 0.32,1.13,2.30 and 5.71mg/L respectively and the average removal rates of NH3-N are 98.5%,94.8%,89.7% and 74.6% respectively.",
        "keywords": [
            "granular active carbon carrier",
            "Rotating biological contactor",
            "sewage treatment",
            "bio-denitrification",
            "domestic sewage"
        ],
        "authors": [
            {
                "name": "TANG Yi",
                "org": "School of Architecture & Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "HUANG Jian-sheng",
                "org": "School of Architecture & Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "YANG Hao-jie",
                "org": "School of Architecture & Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "LI Xiang",
                "org": "School of Architecture & Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Architecture & Environment,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Sichuan Environment",
        "year": 2009
    },
    "nrQNAQ41": {
        "id": "nrQNAQ41",
        "title": "Effects of catholyte and substrate concentration on simultaneous wastewater treatment and electricity production for AFB-MFC",
        "abstract": "In order to improve the performance of anaerobic fluidized bed microbial fuel cell(AFB-MFC) and look for cheap,easy to get and no pollution catholyte for two chambers' MFC,the effects of catholyte and substrate concentration on electricity generation and wastewater treatment were studied.The AFB-MFC system was operated under the conditions of aeration rate of 16~24 L/h,35\u00b12\u2103,distance between the bottom of cathode and the inner bottom of cathode chamber of 17.3 cm,external resistance of 250 \u03a9,hydraulic retention time(HRT) of 14.0~14.9 h and influent pH of 7.81~8.37.The results showed that the best electricity generation was resulted from using tap water as catholyte among buffer solution,anode effluent and tap water.The removal efficiency of substrate was not affected by catholyte.The pH and conductivity of catholyte increased with operation time when tap water was used as catholyte.And COD removal efficiency was 80.11%~89.29%.Voltage and power density increased with time at the beginning,then they stabilized at 440~452 mV and 48.40~51.08 mW/m2.The COD removal efficiency was not affected by substrate concentration,but voltage and power density decreased with the increase of substrate concentration.When the COD concentration of substrate increased from 3 307.09 mg/L to 9 520 mg/L,the COD removal efficiency was 85.77%~94.44% and the voltage and power density decreased from 449 mV and 50.40 mW/m2 to 406 mV and 41.21 mW/m2.Secondary pollution and effects of catholyte to anodic microorganisms can be avoided and high power output was achieved when tap water was used as catholyte.",
        "keywords": [
            "wastewater treatment",
            "electricity generation",
            "anaerobic fluidized bed microbial fuel cell",
            "catholyte",
            "substrate"
        ],
        "authors": [
            {
                "name": "Huang Jiansheng",
                "org": "School of Architecture and Environment,Sichuan University,Chengdu ,China;Chongqing Research Institute of Environmental Sciences,Chongqing ,China"
            },
            {
                "name": "Yang Ping",
                "org": "School of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Guo Yong",
                "org": "School of Chemical Engineering,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Liu Yang",
                "org": "School of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Su Ti",
                "org": "School of Architecture and Environment,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Chinese Journal of Environmental Engineering",
        "year": 2012
    },
    "2l8S8CAB": {
        "id": "2l8S8CAB",
        "title": "Research Status in Microbial Fuel Cell for Recalcitrant Organic Wastewater Treatment",
        "abstract": "Microbial fuel cell(MFC) is a device directly converting organism into electricity with the microbial catalysts.On the basis of it can develop treatment effect as well as product electricity using MFC to treat recalcitrant organic wastewater,microbial fuel cell technology is becoming a rapid evolving field in recent years.In this article,research of status and development trends in several aspects of microbial fuel cells for hard-degradable organic wastewater treatment were summarized and analyzed,especially structures,capability of electricity production and simultaneous biodegradation.",
        "keywords": [
            "electricity production",
            "microbial fuel cells",
            "difficultly degraded organic wastewater",
            "structures"
        ],
        "authors": [
            {
                "name": "CHEN Zhao-yu",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "WANG Jia",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Environmental Science & Technology",
        "year": 2012
    },
    "BEpIveXo": {
        "id": "BEpIveXo",
        "title": "STUDY ON ADVANCED TREATMENT OF COKING WASTEWATER BY MBR",
        "abstract": "The coking wastewater,which had been treated by secondary biochemical treatment,was disposed by internal circulation integrated MBR with polymer micro-carriers.The results showed that high removal efficiency was gained when the COD concentration of influent was 120~320 mg\u00b7L-1 and the coking wastewater was disposed by MBR under intermittent feeding and intermittent aeration mode.The COD removal efficiency was up to 75.0% and the lowest COD concentration of effluent was 46.9 mg\u00b7L-1 when the wastewater with half of coking wastewater was treated by MBR.Meanwhile,the effluent COD concentration was 132.8 mg\u00b7L-1 when the whole coking wastewater was treated.When the effluent of MBR was further disposed by Fenton oxidation,the COD concentration was lower than 75 mg\u00b7L-1.The TN removal efficiency was up to 79.1% when synthetic wastewater was treated.But the TN removal efficiency of coking wastewater was poor.The carriers play an important role on the stable operation of reactor.So the reactor can be extended to treat other coking wastewater systems which have built secondary biochemical treatment or new wastewater treatment systems.",
        "keywords": [
            "porous polymer carriers",
            "integrated membrane bioreactor",
            "coking wastewater"
        ],
        "authors": [
            {
                "name": "Xiao Rongrong",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Yang Haojie",
                "org": "Research Academy of Planning and Designing of Chengdu City,Chengdu ,China"
            },
            {
                "name": "Tang Yi",
                "org": "China National Heavy Machinery Research Institute,Co.Ltd.,Chengdu ,China"
            },
            {
                "name": "Yang Ping",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Technology of Water Treatment",
        "year": 2011
    },
    "MZuuL1YY": {
        "id": "MZuuL1YY",
        "title": "The Development of the Wastewater Treatment Technology\u2500the Biofilm Membrane Bioreactor",
        "abstract": "The article summarizes the technical development of biofilm-membrane bioreactor which is a new technology for wastewater treatment and its advantage and disadvantage and compares several common biofilm-membrane bioreactor.Biofilm-membrane bioreactor that microorganisms grow attached in the filler,could alleviate the membrane fouling and strengthen the capacity of anti-shock load,and has the high removal rate of organic,nitrogen and phosphorus",
        "keywords": [
            "biological filler",
            "membrane fouling",
            "biofilm-membrane bio-reactor"
        ],
        "authors": [
            {
                "name": "PENG Yu-mei",
                "org": "School of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "WU Xin-yue",
                "org": "School of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "SHI Jin-dou",
                "org": "School of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Architecture and Environment,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Environmental Science & Technology",
        "year": 2013
    },
    "GNNlcZn6": {
        "id": "GNNlcZn6",
        "title": "Full-scale Study on Treatment of Strength Recalcitrant Pharmaceutical Wastewater",
        "abstract": "Pharmaceutical wastewater is hard to be treated due to its high COD concentration,great change of water quality and recalcitrant.To treat pharmaceutical wastewater effectively,full scale sewage treatment facilities with physicochemical treatment/UASB/biological contact oxidation was studied,with the effluent satisfying Water Pollutant Discharge Standard of Chemical Synthetic Pharmaceutical Industry of GB 21904-2008.",
        "keywords": [
            "micro electrolysis",
            "biological contact oxidation",
            "pharmaceutical wastewater",
            "UASB",
            "Fenton"
        ],
        "authors": [
            {
                "name": "FAN Xiao-yang",
                "org": ""
            },
            {
                "name": "WANG Jian-jun",
                "org": ""
            },
            {
                "name": "YANG Ping",
                "org": ""
            }
        ],
        "venue": "Environmental Science & Technology",
        "year": 2013
    },
    "J1rClBCx": {
        "id": "J1rClBCx",
        "title": "Electrode of AFB-MFC for Electricity Production and Wastewater Treatment",
        "abstract": "In order to investigate the effects of electrode factors on electricity production and wastewater treatment in microbial fuel cell,a new anaerobic fluidized bed microbial fuel cell (AFB-MFC) was designed.The effects of various cathodes made from different materials,areas of cathode and anode,the distance between the bottom of cathode and the bottom of cathode chamber on the performance of electricity production and wastewater treatment in AFB-MFC were studied.All experiments were operated at the conditions with the aeration rate of 16 \uff5e 24 L/h in cathode chamber,the recirculation flow of 10.7 L/h,the influent flow of 0.6 L/h,the external resistance of 250 \u03a9 and the COD concentration of 3000.98 \uff5e 3789.44 mg/L in influent.It was found that carbon paper was the best one for cathode among carbon paper,copper,aluminum,galvanized iron and iron,all having a size of 15.0 cm \u00d7 3.5 cm.The optimum distance between the bottom of cathode and the bottom of cathode chamber was 17.3 \uff5e20.3 cm.The optimal anode area was 160.0 cm2 when carbon papers with an area of 308.8,232.0,160.0 and 76.8 cm2 were used for anode.The best cathode area was 210.0 cm2 when carbon papers with an area of 241.5,210.0,175.0 and 105.0 cm2 were served as cathode.About 80.00% of COD could be efficiently removed under the optimal operation conditions for AFB-MFC system.The AFB-MFC system which was scaled up is conducive to the practical engineering application in the future.",
        "keywords": [
            "Anaerobic fluidized bed",
            "Anode",
            "Cathode",
            "Electricity production",
            "Microbial fuel cell",
            "Wastewater treatment"
        ],
        "authors": [
            {
                "name": "HUANG Jian-sheng",
                "org": "School of Architecture and Environmental,Sichuan Univ.,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Architecture and Environmental,Sichuan Univ.,Chengdu ,China"
            },
            {
                "name": "GUO Yong",
                "org": "School of Chemical Eng.,Sichuan Univ.,Chengdu ,China"
            }
        ],
        "venue": "Journal of Sichuan University(Engineering Science Edition)",
        "year": 2010
    },
    "zB4jonQY": {
        "id": "zB4jonQY",
        "title": "Centralized Wastewater Managements and Treatments of Industrial Parks",
        "abstract": "Industrial Park has become a concentrated platform for development of industrial enterprises.As the dramatic growth of the economy,the industrial park wastewater pollution has brought a heavy burden on the ecosystem,and its managements or treatments are of great urgency.By analyzing the wastewater characteristics and the concentrated treatment cases of electroplating industrial park,chemical and petrochemical industrial park,textile printing and dyeing industrial park and integrated industrial park,the common prosesses of concentrated managements and treatments are concluded,and some suggestions of concentrated managements and treatments are given for reference.",
        "keywords": [
            "industrial parks",
            "wastewater",
            "concentrated managements and treatments"
        ],
        "authors": [
            {
                "name": "SU Ti",
                "org": "School of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "DONG Bei",
                "org": "School of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Architecture and Environment,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Environmental Science & Technology",
        "year": 2011
    },
    "9XpAubRA": {
        "id": "9XpAubRA",
        "title": "RESEARCH PROCESS OF ADVANCED OXIDATION PROCESSES IN WASTEWATER TREATMENT",
        "abstract": "Advanced oxidation processes can effectively treat industrial wastewater of high density,high toxicity and poor biodegradability.The basic principle of advanced oxidation technologies was reviewed.The research process in recent years for wastewater treatment by Fenton,photo-catalytic oxidation,ozone oxidation,ultrasonic oxidation,wet oxidation and supercritical water oxidation,was summarized.The advantages and shortcomings in practice of each advanced oxidation technology were researched into,and the main development direction in future of them were also pointed out.",
        "keywords": [
            "\u00b7OH",
            "advanced oxidation processes(AOPs)",
            "wastewater treatment"
        ],
        "authors": [
            {
                "name": "Jiang Chuanchun",
                "org": "College of Architecture and Environmental Engineering,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Xiao Rongrong",
                "org": "College of Architecture and Environmental Engineering,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Yang Ping",
                "org": "College of Architecture and Environmental Engineering,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Technology of Water Treatment",
        "year": 2011
    },
    "PTE4fP98": {
        "id": "PTE4fP98",
        "title": "Research on livestock wastewater treatment and producing electricity using anaerobic fluidized bed",
        "abstract": "In order to recycle source of energy from livestock wastewater, using a two-chambered anaerobic fluidized bed microbial fuel cell (AFB-MFC) and taking digested piggery wastewater, low-concentration piggery wastewater and high-concentration piggery wastewater as substance successively, performances of COD (Chemical Oxygen Demand) removal efficiency and electricity production was evaluated at different COD volume loading and feeding ammonia concentration. Using the digested wastewater as the substance, the ammonia caused 7.0% inhibition of electricity production as the ammonia concentration was up to 387.6 mg/L, but the power generation recovered five days later. Using the raw wastewater as the substance, the COD volume loading increased from 2.3 kg \u00b7 m -3 \u00b7 d -1 to 14.9 kg \u00b7 m -3 \u00b7 d -1 within 12 days, and the COD removal efficiencies remained between 74.5% and 88.1%. The output voltage increased slightly with the increasing of COD volume loading, the maximum output voltage and the power density were 379.3mV and 74.9 mW \u00b7 m -2 respectively. Because of the difference of the substance pH, the maximum output voltage of the low-concentration piggery wastewater was 21.4 mV higher than the high-concentration piggery wastewater. The AFB-MFC's internal resistance was 48.5 \u03a9, and the maximum power density was 75.6mW \u00b7 m -2. This study demonstrates that AFB-MFC can treat the livestock wastewater effectively and produce electricity, providing a novel approach for the safe disposal and recycle of livestock wastewater.",
        "keywords": [
            "AFB-MFC",
            "Ammonia",
            "COD removal efficiency",
            "COD volume loading",
            "Voltage control",
            "Wastewater"
        ],
        "authors": [
            {
                "name": "Jianjun Wang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yang Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Changjun Yang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Ping Yang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Nongye Gongcheng Xuebao/Transactions of the Chinese Society of Agricultural Engineering",
        "year": 2012
    },
    "XIex5DKI": {
        "id": "XIex5DKI",
        "title": "Treatment of Organic Wastewater by Rotating Biological Contactor with Granular Biofilm",
        "abstract": "The improved rotating biological contactor was used to treat organic wastewater.The disks were changed into a rotation-cage-type,in which porous polymer carriers were added.The removal efficiencies of COD and NH3-N and the characteristics of biofilm formating on the carriers were investigated.The experimental results indicate that when the COD and NH3-N in the influent are 252 to 538 mg/L(average of 386.6 mg/L) and 22.2 to 51.7 mg/L(average of 33.0 mg/L),the removal rates of COD and NH3-N are 63.6% to 96.4%(average of 85.2%) and 77.8% to 98.7%(average of 86.5%) respectively.The biofilm formation on the carriers is fairly good,and the average thickness of the biofilm is 186.4 \u03bcm.",
        "keywords": [
            "organic wastewater",
            "rotating biological contactor",
            "porous polymer carrier",
            "granular biofilm"
        ],
        "authors": [
            {
                "name": "XIONG Huan-wei",
                "org": "School of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "GUO Yong",
                "org": "School of Chemical Engineering,Sichuan University,Chengdu ,China"
            },
            {
                "name": "LI Li",
                "org": "School of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Architecture and Environment,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "China Water & Wastewater",
        "year": 2009
    },
    "sXN0v3nb": {
        "id": "sXN0v3nb",
        "title": "Research on the Pretreatment of the Pharmaceutical Wastewater by Fenton Reagent and Fe-C Microelectrolysis Process",
        "abstract": "Pharmaceutical wastewater contains large amounts of non-biodegradable chemicals,the BOD5 /COD ratio is ve-ry low,so its biodegradability is very poor.Generally only using biological treatment is difficult to reduce its COD below the emission standards.Now adopting the Fe-C microelectronics and connect Fenton reagent to pretreat pharmaceutical wastewater.The best combination conditions when as COD to the indicator of series experiment of Fe-C-Fenton were:the previous Fe-C microelectrilysis: reaction time was 2.5 h,pH was 5,the mass ratio of Fe/C was 1\u22362,the dosage of Fe was 120 g/L;follow Fenton reagent: added 30% H2O2 3 mL/L and FeSO4\u00b77H2O(100 g/L)1 800 mg/L,and adjusted the reaction time to 2.5 h,pH to 2,the total removal ratio was above 70%,and to pay the way for industrial applications.",
        "keywords": [
            "pharmaceutical wastewater pretreatment",
            "Fe-C microelectrolysis",
            "Fenton reagent"
        ],
        "authors": [
            {
                "name": "PENG Shu-jun",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "DONG Bei",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "QIN Dan",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Environmental Science & Technology",
        "year": 2012
    },
    "OYKWGk9L": {
        "id": "OYKWGk9L",
        "title": "The Treatment of Landfill Leachate by Anaerobic Fluidized Bed-outside Circle Three-phase Aerobic Fluidized Bed",
        "abstract": "The landfill leachate was treated by the combination of anaerobic fluiized bed and outside circle three-phase aerobic fluidized bed systems.The influent CODCr concentration,influent NH3-N concentration,anaerobic CODCr removal rate,anaerobic NH3-N removal rate and other factors were studied on the CODCr and NH3-N removal rate of the Landfill Leachate.The experimental results showed that the landfill leachate of low NH3-N concentration has good treatment efficiency by the joint system,when the total HRT,influent CODCr concentration,influent NH3-N concentration of the treatment systems were 10.5 h,2817.2 ~ 4383.88 mg/L,303.12 ~ 445.43 mg/L,respectively,the removal rates of CODCr and NH3-N were 86.79% ~ 98.85% and 81.14% ~ 94.01%.The Volumetric loading for CODCr and NH3-N achieved an average of 7.38 kg/(m3\u00b7d) and 0.37 kg/(m3\u00b7d).When the CODCr value of Landfill Leachate below 3400 mg/L,there were high CODCr removal rate of 86.79%\uff5e98.85%,when NH3-N concentration below 400 mg/L,the NH3-N in the system had a higher removal rate of 81.14%~94.01%.It was proved that to improve the removal rate of anaerobic CODCr and NH3-N and reduce the NH3-N concentration of anaerobic effluent,will help improve the overall CODCr and total NH3-N removal rate of the combined systems.",
        "keywords": [
            "Anaerobic fluidized bed",
            "Landfill leachate",
            "Outside the circle three-phase aerobic fluidized bed"
        ],
        "authors": [
            {
                "name": "GUO Yong",
                "org": "School of Chem.Eng.,Sichuan Univ.,Chengdu ,China"
            },
            {
                "name": "CHEN Xiao-dong",
                "org": "School of Chem.Eng.,Sichuan Univ.,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Architecture and Environment,Sichuan Univ.,Chengdu ,China"
            }
        ],
        "venue": "Journal of Sichuan University(Engineering Science Edition)",
        "year": 2009
    },
    "dmb5gjSd": {
        "id": "dmb5gjSd",
        "title": "Review of Water Treatment for Low Temperature and Low Turbidity by Using Membrane Technology",
        "abstract": "The treatment of low temperature and low turbidity water was a difficult problem in feed water treatment.In this paper,the reasons for the difficulty in the treatment of the low temperature and low turbidity water using conventional coagulation methods was analyzed,four membrane processing methods to low temperature and low turbidity water were introduced and compared.Many researches indicated that membrane technology had the high-quality and stabling effluent,direct filtration using low-pressure membrane could reduce energy consumption and save coagulants dosing cost,adding powder activated carbon in the coagulation-ultrafiltration technology could increase the removal of dissolve organics,membrane bioreactor also could remove ammonia nitrogen effectively.It was shown that membrane technology was obviously better than conventional processing methods in reducing organics and turbidity and could provide high-quality drinking water,which was the future developing direction for the treatment of low temperature and low turbidity water.",
        "keywords": [
            "low-pressure membrane",
            "ultrafiltration",
            "membrane bioreactor",
            "low temperature and low turbidity water"
        ],
        "authors": [
            {
                "name": "WANG Jia",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "CHEN Zhao-yu",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Resource Development & Market",
        "year": 2011
    },
    "sWyUbZxL": {
        "id": "sWyUbZxL",
        "title": "Influencing factors of AFB-MFC for simultaneous carbon nitrogen removal and electricity generation",
        "abstract": "The influencing factor of anaerobic fluidized bed microbial fuel cell(AFB-MFC) system for simultaneous carbon nitrogen removal and electricity generation were investigated.The results indicated that NH+4-N can not be removed by AFB-MFC,the voltage drop of AFB-MFC system was caused by the decrease of organic substrate concentration.Feeding enough electron donor to AFB-MFC system without adding NO-3-N,the increase of COD/TN was benefited for electricity generation of AFB-MFC system;AFB-MFC presented perfect performance for COD,NO-2-N and NO-3-N removal when 3 inorganic nitrogen were coexistence in AFB-MFC and C/N less than 1.37;AFB-MFC could achieve stable output voltage and power density when influent C/N ranged 1.37-2.50.Fixing the inlet C/N of AFB-MFC system,the NO-2-N,NO-3-N,COD removal efficiency of the system was still desirable even under high carbon nitrogen load,while NH+4-N removal efficiency was not satisfactory.The output voltage and power density of AFB-MFC system had not obvious change when increasing the carbon nitrogen load.Fixing the inlet organic substrate,the plenty of electron donor in AFB-MFC system could ensure the high NO-3-N,COD removal efficiency.The output voltage and power density of AFB-MFC system was increased to a stable value and then decreased with extension the operation time.",
        "keywords": [
            "nitrogen removal",
            "anaerobic fluidized bed microbial fuel cell(AFB-MFC)",
            "electricity generation",
            "electron donor",
            "carbon removal"
        ],
        "authors": [
            {
                "name": "HUANG Jiansheng",
                "org": "Chongqing Research Institute of Environmental Sciences,Chongqing "
            },
            {
                "name": "YANG Ping",
                "org": "School of Architecture and Environment,Sichuan University,Chengdu Sichuan "
            },
            {
                "name": "YANG Changjun",
                "org": "School of Architecture and Environment,Sichuan University,Chengdu Sichuan "
            },
            {
                "name": "MU Shijiang",
                "org": "Chongqing Xinghe Estate Development Co.,Ltd.,Chongqing "
            },
            {
                "name": "MU Bin",
                "org": "Chongqing Identification Station of Agricultural Machinery,Chongqing "
            }
        ],
        "venue": "Environmental Pollution & Control",
        "year": 2012
    },
    "ZP2Y8yIv": {
        "id": "ZP2Y8yIv",
        "title": "Degradation characteristic of ABS resin manufacturing wastewater using different advanced oxidation processible",
        "abstract": "Different advanced oxidation processible (AOPs) was used to pretreat acrylonitrile-butadiene-styrene (ABS) resin manufacturing. Based on the qualitative analysis for the typical pollutants of ABS resin wastewater, the typic compounds of the effluent of different pretreatment were determined and analyzed by gas chromatography mass spectrometry (GC-MS), and the influence of different AOPs to the degradation or transformation of toxic nonbiodegradable typical pollutants was discussed. The results show that the wastewater contains about 10 typical pollutants which are mainly benzene series and organic nitriles, and the relative mass fraction of benzene series are the highest and account for 75.3% of total organic matter. The oxidative degradation capability of Fenton reagent was much stronger than that of the other two methods, and there are only two kinds of small amounts of organic nitriles in the effluent. Therefore, the Fenton reagent method is the best pretreatment method for ABS resin wastewater.",
        "keywords": [
            "ABS resin wastewater",
            "Advanced oxidation processible (AOPs)",
            "GC-MS",
            "Toxic nonbiodegradable typic pollutants"
        ],
        "authors": [
            {
                "name": "Bo Lai",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "ZHOU Yue-xi",
                "org": "Chinese Research Academy of Environmental Sciences(Chinese Research Academy of Environmental Sciences,Chinese Research Academy of Environmental Science),Beijing,China"
            },
            {
                "name": "Ping Yang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "QIN Hong-ke",
                "org": "Chinese Research Academy of Environmental Sciences(Chinese Research Academy of Environmental Sciences,Chinese Research Academy of Environmental Science),Beijing,China"
            },
            {
                "name": "PANG Cui-cui",
                "org": "Chinese Research Academy of Environmental Sciences(Chinese Research Academy of Environmental Sciences,Chinese Research Academy of Environmental Science),Beijing,China"
            },
            {
                "name": "Yu Lian",
                "org": "Chinese Research Academy of Environmental Sciences(Chinese Research Academy of Environmental Sciences,Chinese Research Academy of Environmental Science),Beijing,China"
            }
        ],
        "venue": "Zhejiang Daxue Xuebao (Gongxue Ban)/Journal of Zhejiang University (Engineering Science)",
        "year": 2012
    },
    "ApIfMKO1": {
        "id": "ApIfMKO1",
        "title": "Comparison between Two Carriers Used for Treating Domestic Wastewater in Biological Rotating Cage Reactor",
        "abstract": "It is very important to develop a new type of biological wastewater treatment reactor which has low investment,good resistance to shock loading,less sludge production,lower power consumption and easy maintenance and management.Rotating biological contactor is an efficient biofilm wastewater treatment technology.A biological rotating cage reactor is designed as improvement of rotating biological contactor.A comparative performance between granular activated carbon and multi-surface hollow ball carrier in biological rotating cage reactor is undertaken to evaluate their characteristics.Results showed that granular activated carbon reactor is 5.6% higher than multi-surface hollow ball reactor for average removal rate of COD,and 22.8% for average removal rate of TN,while multi-surface hollow ball reactor is 4.7% higher for average removal rate of NH3-N and stronger oxygen capacity,which showed that the reactor is feasible to be used for small scale sewage treatment.",
        "keywords": [
            "biological rotating cage reactor",
            "sewage treatment",
            "carrier",
            "domestic wastewater",
            "biodenitrification"
        ],
        "authors": [
            {
                "name": "TANG Yi",
                "org": "School of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "LI Yuan-qin",
                "org": "School of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "GUO Yong",
                "org": "School of Chemical Engineering,Sichuan University,Chengdu ,China"
            },
            {
                "name": "CHEN Zhao-yu",
                "org": "School of Architecture and Environment,Sichuan University,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Architecture and Environment,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Environmental Science & Technology",
        "year": 2011
    },
    "SuTSaq2p": {
        "id": "SuTSaq2p",
        "title": "Research and application progress of rural domestic wastewater treatment with constructed wetlands",
        "abstract": "In consideration of the characteristics of rural domestic wastewater,the removal mechanism and existing problems of constructed wetlands were analyzed.A technical and economic analysis was conducted,and the present application of constructed wetlands in rural areas of the world was summarized.The results indicated that,technically,constructed wetlands had high removal efficiencies for organics,from 60 to 99%.With system improvement,combined constructed wetlands,and other combined techniques,the constructed wetlands also showed high removal efficiencies for nitrogen and phosphorous.According to the economic analysis,the capital cost and operation cost of constructed wetlands were much less than that of traditional treatment,and economically feasible.Although constructed wetlands had some problems,such as influence of temperature,wetland plants selection and clogging,the promotion of constructed wetlands in Chinese rural areas was significant as a widely used successful treatment technique in foreign rural areas.",
        "keywords": [
            "removal efficiency",
            "constructed wetlands",
            "rural domestic wastewater",
            "economical efficiency analysis"
        ],
        "authors": [
            {
                "name": "DONG Bei",
                "org": "Department of Architecture and Environment,Sichuan University,Chengdu , China"
            },
            {
                "name": "LIU Yang",
                "org": "Department of Architecture and Environment,Sichuan University,Chengdu , China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Architecture and Environment,Sichuan University,Chengdu , China"
            }
        ],
        "venue": "Water Resources Protection",
        "year": 2011
    },
    "cQbfC6Wk": {
        "id": "cQbfC6Wk",
        "title": "A gesture recognition method based on acceleration feature extraction",
        "abstract": "With the development of mobile devices, gesture recognition based on MEMS accelerometer draws researchers much attention. Due to the restriction of recognition accuracy and efficiency, present methods are still challenging to be applied as a UI. So a simple but effective gesture recognition approach was proposed here. Firstly the ten gestures were classified into four categories according to their linguistic and operation similarity in gesture definition phase. In the recognition phase, the captured gesture was pre-classified by a three-stage classifier with the kinematic features extracted from gesture acceleration. Then the gesture was recognized according to its acceleration changing patterns. Meanwhile, with strict feature threshold restrictions to gestures, the unconscious movements were eliminated significantly. Experiment among 15 volunteers achieved an average accuracy of 95.2% and a recognition time within 0.01 s, which validates the feasibility of the proposed method in terms of accuracy and efficiency.",
        "keywords": [
            "Feature extraction",
            "Gesture recognition",
            "Human computer interaction",
            "MEMS accelerometer"
        ],
        "authors": [
            {
                "name": "Yi Chen",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            },
            {
                "name": "Ping Yang",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            },
            {
                "name": "Xuguang Chen",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            }
        ],
        "venue": "Chinese Journal of Sensors and Actuators",
        "year": 2012
    },
    "S1eTyRM8": {
        "id": "S1eTyRM8",
        "title": "Design and analysis of automobile's vertical anti-collision warning system",
        "abstract": "To prevent collision with the object in front of the car,so that the car is always in a safe driving speeds and reduce accidents,an automobile's vertical anti-collision warning system is designed based on the AT89S52 technology.When in emergency situations that the distance is less than a safe distance.The system can give alarm and remind drivers to pay attention and slow down or apply the brake,so as to effectivly prevent rear-end collision accident and improve the car's active safety performance.To test the system's function and performance and optimal design scheme,a set of simulation program was designed,the result indicated that it can achieve different ways of warning,when inputting datas of warning distance and braking distance.",
        "keywords": [
            "automobile",
            "brake system",
            "anti-collision",
            "warning"
        ],
        "authors": [
            {
                "name": "HE Da-song",
                "org": "Department of Modern Manufacturing,Yibin Vocational and Technical College,Yibin ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            },
            {
                "name": "MEN Yan-hui",
                "org": "Department of Modern Manufacturing,Yibin Vocational and Technical College,Yibin ,China"
            }
        ],
        "venue": "Transducer and Microsystem Technologies",
        "year": 2010
    },
    "pbbA5TpM": {
        "id": "pbbA5TpM",
        "title": "The Orbit Estimation and Error Analysis of the Spacecraft's Powered Phase",
        "abstract": "Numerical solution of differential equations was used to calculate two observation satellites'three-dimensional position.Based on the calculation,the positioning middle value estimation model and the optimization model were built to obtain the orbit and the existing three axis pointing error estimation,with the idea of Bi-satellite positioning.Position radius was put forward as the judgment standard of the precision improving under the consideration of system error model.",
        "keywords": [
            "orbit estimation",
            "3-axis pointing error",
            "position radius",
            "Bi-satellite positioning"
        ],
        "authors": [
            {
                "name": "LIU Xiao-dan",
                "org": "University of Electronic Science and Technology of China,Chengdu ,China"
            },
            {
                "name": "ZHANG Long-long",
                "org": "University of Electronic Science and Technology of China,Chengdu ,China"
            },
            {
                "name": "WANG Xing",
                "org": "University of Electronic Science and Technology of China,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "University of Electronic Science and Technology of China,Chengdu ,China"
            }
        ],
        "venue": "Mathematics in Practice and Theory",
        "year": 2013
    },
    "DAxzP31z": {
        "id": "DAxzP31z",
        "title": "Parameter Analysis and Design of Voltage Doubling Rectifier Circuit",
        "abstract": "The principles of voltage doubling rectifier circuit are introduced,through the simulation of Protel DXP,the impact of various parameters in the circuit to the size of the output voltage and ripple are verified,at the same time the impact of the different capacitances' value change to the output are analyzed,the conclusion will provide a theoretical basis for the parameter selection of the voltage doubling rectifier circuit,and build the actual circuit,test waveforms,verify the simulation results.",
        "keywords": [
            "voltage doubling rectifier simulation of the protel parametric analysis"
        ],
        "authors": [
            {
                "name": "CHEN Xiang",
                "org": "Institute of Mechanical and Electronic Engineering,University of Electronic Science and Technology of China,Chengdu ,P.R.China"
            },
            {
                "name": "WANG Cong-ling",
                "org": "Institute of Mechanical and Electronic Engineering,University of Electronic Science and Technology of China,Chengdu ,P.R.China"
            },
            {
                "name": "YANG Ping",
                "org": "Institute of Mechanical and Electronic Engineering,University of Electronic Science and Technology of China,Chengdu ,P.R.China"
            },
            {
                "name": "LIAO Li",
                "org": "Institute of Mechanical and Electronic Engineering,University of Electronic Science and Technology of China,Chengdu ,P.R.China"
            }
        ],
        "venue": "Science Technology and Engineering",
        "year": 2012
    },
    "LLkax0rt": {
        "id": "LLkax0rt",
        "title": "A gesture recognition method based on MEMS IMU",
        "abstract": "With the development of smart mobile devices, such as mobile phones, gesture recognition based on MEMS inertial sensor and embedded system has become a research hotspot. A simple but effective gesture recognition method is proposed here. In gesture defined phase, 14 gestures are defined, and divided into three categories based on the similarity linguistic and operating. In gesture segmentation phase, the gesture was captured with the kinematic features share by all gestures. In gesture recognized phase, the captured gestures are pre-classified by a two-stage decision tree classifier with the acceleration and angular velocity kinematic features of the various categories of gestures respectively. Experiment among 20 experimenters achieved an average accuracy of 96%. Gesture recognition time is less than 0.01 s. The results show that the proposed method can recognize gestures rapidly and accurately under embedded system and it meet the requirements of real-time human-computer interaction.",
        "keywords": [
            "Feature extraction",
            "Gesture recognition",
            "Human interaction",
            "MEMS inertial sensor"
        ],
        "authors": [
            {
                "name": "Qian Xiao",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            },
            {
                "name": "Ping Yang",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            },
            {
                "name": "Libo Xu",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            }
        ],
        "venue": "Chinese Journal of Sensors and Actuators",
        "year": 2013
    },
    "GYPIibd8": {
        "id": "GYPIibd8",
        "title": "Obstacle position estimation based on correction matrix of the least square method multisensor fusion",
        "abstract": "In obstacle position detection,because of sensor error existence,the multisensor fusion are used to reduce the uncertainty so that the estimation result is reliable.A new method based on correction matrix of the least square method multisensor fusion is proposed.A correction matrix is set up by the prior information of IR(infrared ray)sensor.The linear credibility weighted equation are obtained,according to the least square method principle.Simulation and experiment in mobile robot\"FutureStar\"are done with and without correction matrix,and it shows that the least square method can greatly reduce uncertainty and the estimation with correction matrix is more close to the true value.",
        "keywords": [
            "multisensor fusion",
            "the least square method",
            "uncertainty",
            "correction matrix"
        ],
        "authors": [
            {
                "name": "BAO Bi-zhen",
                "org": "School of Mechatronics Engineering,University of Electronic Science andTechnology of China,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Mechatronics Engineering,University of Electronic Science andTechnology of China,Chengdu ,China"
            },
            {
                "name": "CAO Hu-wen",
                "org": "School of Mechatronics Engineering,University of Electronic Science andTechnology of China,Chengdu ,China"
            }
        ],
        "venue": "Transducer and Microsystem Technologies",
        "year": 2011
    },
    "XVgP5vPi": {
        "id": "XVgP5vPi",
        "title": "State Space Modeling and Digital Design of High-precision Pneumatic Servo Valve",
        "abstract": "Performance of servo valve is the determining factor that influences performance of a pneumatic precise positioning system.To improve the performance of a pneumatic system,improvement of the servo valve characteristic is extremely important.Structure characteristics of a recently developed high precision pneumatic servo valve were analyzed.Its state space model was built,a digital controller was designed and simulated.The simulation results show that this digital controller is effective,and static and dynamic performances of the pneumatic servo valve are notably improved.",
        "keywords": [
            "Discrete time system",
            "State estimation",
            "State space modeling",
            "Pneumatic servo valve"
        ],
        "authors": [
            {
                "name": "HUANG Tao",
                "org": "School of Mechatronics Engineering of University of ElectronicScience and Technology of China,Chengdu Sichuan ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Mechatronics Engineering of University of ElectronicScience and Technology of China,Chengdu Sichuan ,China"
            },
            {
                "name": "JIANG Dan",
                "org": "School of Mechatronics Engineering of University of ElectronicScience and Technology of China,Chengdu Sichuan ,China"
            }
        ],
        "venue": "Machine Tool & Hydraulics",
        "year": 2011
    },
    "i7DYHdqV": {
        "id": "i7DYHdqV",
        "title": "Cell gesture recognition based on inertial sensors",
        "abstract": "With gesture input,cell phones can be much more functional,convenience and funny.The core of this input way is recognizing the current gesture quickly and accurately.A method of recognize the gesture based on inertial sensors is tested in this paper,and it is proved useful.",
        "keywords": [
            "human-machine interaction",
            "fusion algorithm",
            "inertial sensors",
            "gesture recognition"
        ],
        "authors": [
            {
                "name": "Liu Yu",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            },
            {
                "name": "Yang Ping",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            },
            {
                "name": "Duan Bingtao",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            }
        ],
        "venue": "Application of Electronic Technique",
        "year": 2011
    },
    "l7Eysn4n": {
        "id": "l7Eysn4n",
        "title": "The Secondary Separation from Axis Turning Error Based on Three Points Measuring",
        "abstract": "For improving the measuring precision of axis turning error, this paper presents the secondary error separation technique from axis turning error on the basis of three-points measuring, and also introduces modeling of the secondary error separation. By way of introducing acceleration sensors to get axis vibrating acceleration signal, therefore the axis vibrating displacement can be obtained and further removed from axis turning error based on three-points measuring.",
        "keywords": [
            "Vibrating Displacement",
            "Vibration",
            "Three-points Measuring",
            "Error Separation",
            "Turning Error"
        ],
        "authors": [
            {
                "name": "LIU Shutao",
                "org": "School of Mechatronics Engineering, University of Electronic Science and Technology of China, Chengdu , CHN"
            },
            {
                "name": "YANG Ping",
                "org": "School of Mechatronics Engineering, University of Electronic Science and Technology of China, Chengdu , CHN"
            },
            {
                "name": "KANG Haiyan",
                "org": "School of Mechatronics Engineering, University of Electronic Science and Technology of China, Chengdu , CHN"
            }
        ],
        "venue": "Manufacturing Technology & Machine Tool",
        "year": 2008
    },
    "XbwKE9Fo": {
        "id": "XbwKE9Fo",
        "title": "Development of networked virtual logic analyzer",
        "abstract": "In order to highlight specialty features and improve engineer qualities of students,a networked virtual logic analyzer for experimental teaching is developed based on the traditional logic analyzer and virtual instruments.The hardware and software for this system are described.The test results show this system can meet experimental requirements,realize remote data acquisition,analysis and display,meanwhile obtain good effects in experimental teaching for undergraduates.",
        "keywords": [
            "virtual logic analyzer",
            "remote experiment",
            "networked experiment"
        ],
        "authors": [
            {
                "name": "Shen Yan",
                "org": "Department of Control Engineering,Chengdu University of Information Techndogy,Chengdu,,China"
            },
            {
                "name": "Yang Ping",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            },
            {
                "name": "Gu Tianxiang",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            },
            {
                "name": "Wang Lunfa",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            }
        ],
        "venue": "Experimental Technology and Management",
        "year": 2010
    },
    "b3bgmwKG": {
        "id": "b3bgmwKG",
        "title": "The Analysis and Research for the Speed Control Effect in Two Speed Regulator Installation Ways",
        "abstract": "The speed regulator is used to adjust the speed of the components in pneumatic system.It has two installation ways as inlet throttling and exhaust throttling.These two ways can both adjust the speed of the pneumatic actuators,but the effects are different.Three ways is used that theoretical analysis,software simulation and test analysis to compare the two installation ways.Through the research,the conclusion that exhaust throttling is better than inlet throttling is got.",
        "keywords": [
            "speed regulator inlet throttling exhaust throttling speed control effect"
        ],
        "authors": [
            {
                "name": "LIAO Li",
                "org": "University of Electronic Science and Technology School of Mechatronics Engineering Chengdu ,P.R.China"
            },
            {
                "name": "WANG Cong-ling",
                "org": "University of Electronic Science and Technology School of Mechatronics Engineering Chengdu ,P.R.China"
            },
            {
                "name": "YANG Ping",
                "org": "University of Electronic Science and Technology School of Mechatronics Engineering Chengdu ,P.R.China"
            },
            {
                "name": "MA Ren-tian",
                "org": "University of Electronic Science and Technology School of Mechatronics Engineering Chengdu ,P.R.China"
            }
        ],
        "venue": "Science Technology and Engineering",
        "year": 2012
    },
    "mxBbR79W": {
        "id": "mxBbR79W",
        "title": "Air Cylinder Monitoring System Based on ZigBee Wireless Sensor Network",
        "abstract": "Based on ZigBee Wireless Sensor Network(WSN) technology,this paper fulfills the function of transmiting and controlling the cylinder location information wirelessly in the industrial environment.This paper briefly introduced the solutions of cylinder wireless system.The system mainly included the terminal node and the center node,which were designed by CC2430 and the non-contact magnetic sensor.Then it provided the process of system software implementation.It made effective use of the interface of ZigBee protocol stack to establish the network,join to the network,bind with the terminal node.After primarily debugging in lab,this system can realize the convenience,effectiveness,innovation and universality of cylinder monitoring wirelessly.It can consequently reduce the complex wiring problems of industrial layout and improve the scene monitoring of pneumatic equipment.",
        "keywords": [
            "WSN",
            "cylinder monitoring",
            "ZigBee"
        ],
        "authors": [
            {
                "name": "ZHAI Zhi-min",
                "org": "College of Mechanical Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Mechanical Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            },
            {
                "name": "WEI Wei",
                "org": "College of Mechanical Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            }
        ],
        "venue": "Instrument Technique and Sensor",
        "year": 2012
    },
    "MiaBQ6nR": {
        "id": "MiaBQ6nR",
        "title": "Research and Realization of Reliability Testing System of Pneumatic Cylinder",
        "abstract": "In the most widely used machine of pneumatic applications,the reliability of cylinder is the precondition of the security of the whole system.By the study of the theoretic reliability testing of cylinder,this paper design and implement a reliability testing system of the cylinder based on SMC's CJ2B10-20 cylinder.The uninterrupted experiment for up to one year and the testing data obtained indicate that the reliability testing system of cylinder runs stably,collects,stores and analyzes data easily.This system satisfies the needs of the reliability testing of cylinder.",
        "keywords": [
            "life-testing",
            "reliability",
            "testing",
            "pneumatic cylinder"
        ],
        "authors": [
            {
                "name": "LIU Wei",
                "org": "School of Mechanical and Electronic Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            },
            {
                "name": "WANG Cong-ling",
                "org": "School of Mechanical and Electronic Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Mechanical and Electronic Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            }
        ],
        "venue": "Automation & Instrumentation",
        "year": 2009
    },
    "NAHC7WhL": {
        "id": "NAHC7WhL",
        "title": "The research of pneumatic system based on T-S model fuzzy PID control",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ZHANG Jun-zhao",
                "org": ""
            },
            {
                "name": "WANG Cong-ling",
                "org": ""
            },
            {
                "name": "YANG Ping",
                "org": ""
            },
            {
                "name": "HUANG Tao",
                "org": ""
            }
        ],
        "venue": "Chinese Hydraulics & Pneumatics",
        "year": 2012
    },
    "cQPlPfid": {
        "id": "cQPlPfid",
        "title": "Analysis and Processing on Zero Position Error of MEMS Gyroscope",
        "abstract": "Study on zero position error of MEMS gyroscope has a great value on improving the accuracy of inertial navigation system.Allan variance analysis method was adopted to evaluate on zero position error of MEMS gyroscope.A kind of dynamic zero offset compensation algorithm was presented to eliminate the zero offset error.HDR(Heuristic Drift Reduction)was also improved and the compensation accuracy of original algorithm was increased effectively.Finally,Allan variance analysis method was adopted to evaluate on the compensated zero position error.Test had been done with the platform of gyro-equipped indoor mobile robot Voyager-IIA and the results show precision was increased significantly with the improved algorithm.",
        "keywords": [
            "Allan variance analysis",
            "Dynamic compensation",
            "HDR",
            "MEMS gyroscope",
            "Zero position error"
        ],
        "authors": [
            {
                "name": "CHEN Xuguang",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            },
            {
                "name": "CHEN Yi",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            }
        ],
        "venue": "Chinese Journal of Sensors and Actuators",
        "year": 2012
    },
    "9jsl8QNb": {
        "id": "9jsl8QNb",
        "title": "The learning and application of Matlab based on thetemperature-resistance relationship analysis of temperature sensitive resistors",
        "abstract": "As a computational tool,Matlab has powerful capability and is easy to operate.It is significant for undergraduates in engineering fields to learn Matlab and solve practical engineering issues by it.The temperature-resistance relationship analysis of temperature sensitive resistors is investigated as a case through the Matlab programming in this study.An easy and effective method to obtain temperature-resistance relationship is proposed and verified as well.Through the case analysis,a procedure to adopt Matlab for solving practical issues is presented.",
        "keywords": [
            "temperature-resistance characteristics",
            "temperature sensitive resistors",
            "Matlab"
        ],
        "authors": [
            {
                "name": "FAN Xian-feng",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            },
            {
                "name": "MIAO Qiang",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            }
        ],
        "venue": "Experimental Technology and Management",
        "year": 2008
    },
    "cnI4WzcB": {
        "id": "cnI4WzcB",
        "title": "Study on Axial Vibration Testing and Analysis with High Speed",
        "abstract": "For judging the precise and high-speed axes whether qualified or reassemble,to make sure the accuracy and quality of it,build up a set of measure method about the vibration of axes,master the originality data,analyse the vibration model, find out the influence factor of vibration which is main,which is subordination.Analyse and judge the factor,provide a warranty for the quality of axes.",
        "keywords": [
            "high speed axes",
            "dynamic banlance",
            "measure",
            "vibration"
        ],
        "authors": [
            {
                "name": "KANG Hai-yan",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            },
            {
                "name": "LIU Shu-tao",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            }
        ],
        "venue": "Machinery & Electronics",
        "year": 2008
    },
    "wkCtk8hR": {
        "id": "wkCtk8hR",
        "title": "Design and Implementation of Cylinder Fatigue Damage Prediction of Test Platform",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ZHOU Tai",
                "org": ""
            },
            {
                "name": "WANG Cong-ling",
                "org": ""
            },
            {
                "name": "YANG Ping",
                "org": ""
            },
            {
                "name": "CHEN Xiang",
                "org": ""
            }
        ],
        "venue": "Chinese Hydraulics & Pneumatics",
        "year": 2013
    },
    "kV2j9OGZ": {
        "id": "kV2j9OGZ",
        "title": "The Realization of FFT with C Language Based on Improved Repeat Algorithm",
        "abstract": "Because it is too complex to actualize fast fourier transform algorithm with assembly lan- guage in DSP device and the currency of assembly language is too bad,the repeat arithmetic is intro- duced.This arithmetic can make antitone array process be easy in program and C language can be used to write program.Based on repeat arithmetic, improved repeat arithmetic is put forward and the blocking of basic matrix is introduced.Both of them can make fast fourier transform algorithm be simplified and modularized and have well currency.",
        "keywords": [
            "FFT",
            "improved repeat arithmetic",
            "basic matrix",
            "repeat arithmetic"
        ],
        "authors": [
            {
                "name": "LIU Shu-tao",
                "org": "School of Mechatronic Engineering of University of Electronic Science and Technology of China,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Mechatronic Engineering of University of Electronic Science and Technology of China,Chengdu ,China"
            }
        ],
        "venue": "Machinery & Electronics",
        "year": 2008
    },
    "O1zaVKwL": {
        "id": "O1zaVKwL",
        "title": "The Fatigue Life Analysis of Pneumatic Cylinder Based on ANSYS",
        "abstract": "This paper conducted a numerical simulation by using ANSYS to model a cylinder with an impact load function and obtained the stress distribution contours for the cylinder with the impact of piston rod. Based on the simulation model, the ANSYS software is adopted to analyze the fatigue life for the cylinder and obtain the fatigue using life. And then, a fatigue test of cylinder is carried out through a pneumatic test platform to get the failure sample and fatigue life of the cylinder. Through this test, the rationality of analyzing the cylinder with the finite element method and stress-life method to get the fatigue life is validated, which will provide a method and basis for the prediction of fatigue life for the cylinder.",
        "keywords": [
            "Simulation analysis",
            "Finite element method",
            "Pneumatic cylinder",
            "Fatigue life"
        ],
        "authors": [
            {
                "name": "MA Rentian",
                "org": " School of Mechatronics Engineering, University of Electronic Science and Technology of China, Chengdu , China"
            },
            {
                "name": "YANG Ping",
                "org": " School of Mechatronics Engineering, University of Electronic Science and Technology of China, Chengdu , China"
            },
            {
                "name": "JIANG Dan",
                "org": " School of Mechatronics Engineering, University of Electronic Science and Technology of China, Chengdu , China"
            },
            {
                "name": "LIAO Li",
                "org": " School of Mechatronics Engineering, University of Electronic Science and Technology of China, Chengdu , China"
            }
        ],
        "venue": "Hydromechatronics Engineering",
        "year": 2012
    },
    "BfUCZ27t": {
        "id": "BfUCZ27t",
        "title": "Reliability analysis of a small pneumatic cylinder based on weibull distribution",
        "abstract": "In the application of pneumatic system,the reliability of cylinder as an executive mechanism most of time is a precondition for security of the whole system.Based on the conventional life test of a small high-speed pneumatic cylinder,a failure model is determined through failure mechanism analysis.According to statistics on reliability,the specific distribution form for cylinder life is determined.Then median rank method is applied in pre-processing failure data,and the least squares estimation method is proposed with the utilization of computers to achieve the reliability characteristic parameters,on which a model for analyzing pneumatic cylinder reliability is established.With this model the distribution of the reliability of the pneumatic cylinder is obtained,which provide a feasible method for quantitative analysis of the reliability of the pneumatic cylinder.",
        "keywords": [
            "Reliability",
            "Weibull distribution",
            "Least-squares method",
            "Pneumatic cylinder"
        ],
        "authors": [
            {
                "name": "FANG Xue-fa",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China, Chengdu ,China"
            },
            {
                "name": "WANG Cong-ling",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China, Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China, Chengdu ,China"
            }
        ],
        "venue": "Machinery Design & Manufacture",
        "year": 2011
    },
    "m85GupQA": {
        "id": "m85GupQA",
        "title": "Experimental study on the influence of bubbles on dynamic characteristics of valve-less micropump",
        "abstract": "The actions of bubbles in a piezoelectric valve-less nozzle/diffuser micropump,including entrance,movement,combination and separation in the pump chamber,are recorded by a high speed video camera.A piezoresistive micro pressure transducer is used to measure the pressure pulsations in the piezoelectric valve-less micropump chamber.Experimental results show that the effective bulk modulus of fluid and the amplitude of pressure pulsations in the valve-less micropump decrease significantly with the bubbles into the pump chamber.The entrance of bubbles can lead to performance deterioration and even complete failure of the micropump.However,the movement,combination and separation of bubbles have little effect on the effective bulk modulus of fluid and the dynamic characteristics of micropump.",
        "keywords": [
            "Bubble",
            "High-speed video",
            "Pressure pulsation",
            "Valve-less micropump"
        ],
        "authors": [
            {
                "name": "JIANG Dan",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            },
            {
                "name": "LI Song-jing",
                "org": "School of Mechatronics Engineering,Harbin Institute of Technology,Harbin ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            }
        ],
        "venue": "Journal of Experiments in Fluid Mechanics",
        "year": 2010
    },
    "gdd4Qfs4": {
        "id": "gdd4Qfs4",
        "title": "Study on robot obstacle avoidance based on sonar ring sensor",
        "abstract": "Any robot aiming to achieve autonomous navigation in unknown environment must effectively and reliably perceive environmental information,and ultrasonic wave sensor plays a wide role in detecting obstacles distance information.Design and implementation principle of the sonar ring sensor system of travels II is introduced,and the precision of sonar is test.On the basis of these,a simple mobile robot obstacle avoidance strategy is proposed,and two basic static and dynamic obstacle avoidance experiments are used.The experiments verify the correctness and effectiveness of obstacle avoidance strategy.",
        "keywords": [
            "static obstacle avoidance",
            "dynamic obstacle avoidance",
            "sonaring sensor"
        ],
        "authors": [
            {
                "name": "DUAN Bing-tao",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China, Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China, Chengdu ,China"
            },
            {
                "name": "ZHAI Zhi-min",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China, Chengdu ,China"
            }
        ],
        "venue": "Transducer and Microsystem Technologies",
        "year": 2012
    },
    "BJtiJ6QX": {
        "id": "BJtiJ6QX",
        "title": "Speed Control of BLDCM in Compensating Factor Based on AT90PWM3",
        "abstract": "To control low power BLDCM conveniently,accuratly,steadily,the compensating factor method as a new speed control algorithm was presented,the hardware in which AT90PWM3 of AVR is used as the main controlling chip was designed and host and lower code were programmed.Simulation shows the compensating factor algorithm is the better control way when comparing it with open loop,signal closed loop and double closed loop in starting and steady speed curves.",
        "keywords": [
            "brushless DC motor(BLDCM)",
            "speed curve",
            "compensating factor"
        ],
        "authors": [
            {
                "name": "BAO Bi-zhen",
                "org": "School of Mechatronics Engineering of UESTC,Chengdu ,Sichuan,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Mechatronics Engineering of UESTC,Chengdu ,Sichuan,China"
            },
            {
                "name": "WANG Hai-feng",
                "org": "School of Mechatronics Engineering of UESTC,Chengdu ,Sichuan,China"
            }
        ],
        "venue": "Electric Drive",
        "year": 2010
    },
    "WuZw6JdS": {
        "id": "WuZw6JdS",
        "title": "Application of AMESim in Praxis Teaching of Hydraulic Transmission",
        "abstract": "In order to compare characteristics between throttle valve and speed regulator valve in praxis teaching of Hydraulic Transmission,the model of meter-in circuit using throttle valve and using speed regulator valve by AMESim software are established and simulated.The intuitive data and visualization of simulation results help students achieve deep comprehension of flow control components and circuits.It inspires their learning interests and improves abilities of independent study and practical innovation.",
        "keywords": [
            "speed regulator valve",
            "throttle valve",
            "hydraulic transmission",
            "praxis teaching",
            "AMESim software"
        ],
        "authors": [
            {
                "name": "JIANG Dan",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            },
            {
                "name": "WANG Cong-ling",
                "org": "School of Mechatronics Engineering,University of Electronic Science and Technology of China,Chengdu ,China"
            }
        ],
        "venue": "Experiment Science and Technology",
        "year": 2012
    },
    "cgoGg4k7": {
        "id": "cgoGg4k7",
        "title": "Development of networked integrated test system",
        "abstract": "In order to highlight specialty feature and improve engineering quality of students,networked integrated test system for engine is developed which is used to test pulse pressure,revolution swing and fuel flux based on test technology,computer and network technology.The hardware and software for this test system are described.The test results show that this test system can realize remote data acquisition and obtain good effect in experiment teaching for undergraduates.",
        "keywords": [
            "remote test",
            "integrated test system",
            "networked experiment"
        ],
        "authors": [
            {
                "name": "SHEN Yan",
                "org": "College of Mechanical and Electronic Engineering,University of Electronic Science & Technology of China,Chengdu ,China"
            },
            {
                "name": "LI Xun-bo",
                "org": "College of Mechanical and Electronic Engineering,University of Electronic Science & Technology of China,Chengdu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Mechanical and Electronic Engineering,University of Electronic Science & Technology of China,Chengdu ,China"
            },
            {
                "name": "GU Tian-xiang",
                "org": "College of Mechanical and Electronic Engineering,University of Electronic Science & Technology of China,Chengdu ,China"
            },
            {
                "name": "YUAN Liang",
                "org": "College of Mechanical and Electronic Engineering,University of Electronic Science & Technology of China,Chengdu ,China"
            }
        ],
        "venue": "Experimental Technology and Management",
        "year": 2008
    },
    "k04Wy4hr": {
        "id": "k04Wy4hr",
        "title": "NEW ULTRASONIC FLOWMETER BASED ON DSP",
        "abstract": "Accuracy is the urgent question for the traditional ultrasonic flowmeter.The phase difference method is used to measure the flow in this design through analyzing the physical model of ultrasonic flowmeter.The key is analysis how the speed of sound impacts on flow.Not only the speed of sound is adjusted using the correction phase circuit,but also the TI's high performance DSP chip TMS320VC5402 is used as the processor.So the accuracy of measurement is improved greatly.It can be seen that the method is high measurement accuracy,rapid and high reliability through the actual measurement.",
        "keywords": [
            "phase difference",
            "DSP",
            "ultrasonic flowmeter"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "School of Electrical and Information Engineering,Shaanxi University of Science & Technology,Xi'an ,China"
            },
            {
                "name": "ZHANG Yu-jie",
                "org": "School of Electrical and Information Engineering,Shaanxi University of Science & Technology,Xi'an ,China"
            },
            {
                "name": "WU Dan-hui",
                "org": "School of Electrical and Information Engineering,Shaanxi University of Science & Technology,Xi'an ,China"
            }
        ],
        "venue": "Journal of Shaanxi University of Science & Technology(Natural Science Edition)",
        "year": 2009
    },
    "a8iP1n2n": {
        "id": "a8iP1n2n",
        "title": "RESEARCH ON THE CHAOTIC SYNCHRONIZATION SELF-MAINTENANCE CHARACTERISTIC BASED ON CHUA'S CIRCUIT",
        "abstract": "In this paper,Chua's circuit and its characteristics,as well as the circuit of realizing non-linearity resistance,are presented.Utilizing Chua's circuit,a drive-response chaotic synchronization system is constructed,by means of imitation,it can be concluded that this synchronization system possesses to a certainly stability\u3001resisting-disturbance,and so on;Based on its system and by means of imitation,the characteristic of the chaotic synchronization self-maintenance is put forward,and imitation results are also presented.This first discovery provides the foundation of putting chaos into practical application to secret communication.",
        "keywords": [
            "chaotic synchronization self-maintenance",
            "Chua's circuit",
            "chaotic synchronization"
        ],
        "authors": [
            {
                "name": "WU Dan-hui",
                "org": "School of Electrical and Electronic Engineering,Shaanxi University of Science & Technology,Xianyang ,China"
            },
            {
                "name": "ZHANG Yu-jie",
                "org": "School of Electrical and Electronic Engineering,Shaanxi University of Science & Technology,Xianyang ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Electrical and Electronic Engineering,Shaanxi University of Science & Technology,Xianyang ,China"
            },
            {
                "name": "YANG Fan",
                "org": "School of Electrical and Electronic Engineering,Shaanxi University of Science & Technology,Xianyang ,China"
            }
        ],
        "venue": "Journal of Shaanxi University of Science & Technology",
        "year": 2006
    },
    "1hFcm34z": {
        "id": "1hFcm34z",
        "title": "Application of DDS Technology in Intelligent Correlative Flow Measurement",
        "abstract": "Principle and measure method of ultrasonic correlative flowmeter is introduced in this paper at first. On the basis of it, the necessity of generating high precision sine wave is demonstrated.Not only structure and rule of DDS technology,but also basic princi- ple and performance of AD9850 are discussed.Finally,not only sine wave signal generator but also AM and FM signal generator com- posed of DDS chip AD9850 and DSP chip TMS320VC5402 are designed. The results of experiments verify that the technique and the system in this paper are feasible and effective.",
        "keywords": [
            "DDS",
            "DSP",
            "correlation",
            "FPGA"
        ],
        "authors": [
            {
                "name": "Yang Ping",
                "org": ""
            },
            {
                "name": "Yang Liangyu",
                "org": ""
            },
            {
                "name": "Zhang Yujie",
                "org": ""
            },
            {
                "name": "Wu Danhui",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2007
    },
    "KSpFmefW": {
        "id": "KSpFmefW",
        "title": "RESARCH OF WORKFLOW SYSTEM BASED ON RELATIONSHIP DATA BASE",
        "abstract": "It brings up a research project of workflow system based on relevant database and Web-oriented in this paper. It describes the unique advantage of the system in detail; provides complete event-driven workflow engine adopted by the system; recommends modeling structure of workflow system; provides systematic key technology and innovation at finally.",
        "keywords": [
            "workflow mode",
            "workflow definition",
            "workflow engine",
            "Module",
            "workflow"
        ],
        "authors": [
            {
                "name": "XU Qian",
                "org": "School of Electricity and Information Engineering, Shaanxi University of Science & Technology, Xianyang ,China"
            },
            {
                "name": "WU Dan-hui",
                "org": "School of Electricity and Information Engineering, Shaanxi University of Science & Technology, Xianyang ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Electricity and Information Engineering, Shaanxi University of Science & Technology, Xianyang ,China"
            }
        ],
        "venue": "Journal of Shaanxi University of Science & Technology",
        "year": 2006
    },
    "BzJW0rXU": {
        "id": "BzJW0rXU",
        "title": "New Ultrasonic Flowmeter of Correlation Based on DSP",
        "abstract": "Dynamics characteristic of multiphase flow is so complex that multiphase flowmeter have no satisfied result. By use of correlation theory , ultrasonic flowmeter based on DSP can solve many problems on multiphase flowmeter. The flowmeter have core of TMS320VC5402. Time-of-flight (TOF) and flow are calculated rapidly because of strong and fast operation ability of DSP. So it has good antijamming capability and high accuracy measurement. The flowmeter is proved precise and stable and reliable by virtue of large measure data.",
        "keywords": [
            "DDS",
            "time-of-flight (TOF)",
            "DSP",
            "correlation"
        ],
        "authors": [
            {
                "name": "Yang Ping",
                "org": " College of Electric and Electronic, Shaanxi University of Science and Technology, Xianyang , China, School of Electric and Control Engineering, Xi'an University of Science and Technology, Xi'an , China"
            },
            {
                "name": "Zhang Yujie",
                "org": " College of Electric and Electronic, Shaanxi University of Science and Technology, Xianyang , China, School of Electric and Control Engineering, Xi'an University of Science and Technology, Xi'an , China"
            },
            {
                "name": "Yang Liangyu",
                "org": " College of Electric and Electronic, Shaanxi University of Science and Technology, Xianyang , China, School of Electric and Control Engineering, Xi'an University of Science and Technology, Xi'an , China"
            },
            {
                "name": "Yang Yongqiang",
                "org": " College of Electric and Electronic, Shaanxi University of Science and Technology, Xianyang , China, School of Electric and Control Engineering, Xi'an University of Science and Technology, Xi'an , China"
            }
        ],
        "venue": "Computer Measurement & Control",
        "year": 2006
    },
    "bZVh5xdX": {
        "id": "bZVh5xdX",
        "title": "Research on the Influence of Noise to Weak Signal Detection Based on Duffing equation",
        "abstract": "In view of existing questions of misjudgment,low efficiency,and error in detecting weak signal using chaos critical state.The basic form of Duffing equation is firstly established and analyzed in this paper;and then,it describes the principle of weak signal detection based on the change of phase trace;The influence of Noise to weak signal detection performance is researched using chaos critical state detection method;Stochastic resonance phenomenon of the small-signal two-dimensional nonlinear system is found,and that,the research in the paper provides some foundation for enhancing detection signal SNR under the strong noise background and a new way for detecting weal signal using stochastic resonance.",
        "keywords": [
            "weak signal detection",
            "duffing equation",
            "stochastic resonance",
            "noise"
        ],
        "authors": [
            {
                "name": "Wu Danhui",
                "org": "College of Electronics and Electrical Engineering,Shan'Xi University of Science and Technology,Shan'Xi ,China"
            },
            {
                "name": "Li Qinjun",
                "org": "College of Electronics and Electrical Engineering,Shan'Xi University of Science and Technology,Shan'Xi ,China"
            },
            {
                "name": "Yang Ping",
                "org": "College of Electronics and Electrical Engineering,Shan'Xi University of Science and Technology,Shan'Xi ,China"
            }
        ],
        "venue": "Computer Measurement & Control",
        "year": 2010
    },
    "oi25qPjg": {
        "id": "oi25qPjg",
        "title": "Application Research of Detecting Weak Random Binary Code Based on Stochastic Resonance",
        "abstract": "The phenomenon of stochastic resonance based on two-dimensional bistable Duffing system under the conditions of small signal is analyzed in this paper;the detection methods of faint random binary code based on stochastic resonance technique of Duffing system is presented.Using this method,under the conditions of no knowing any priori knowledge of detection signal,the detected signal waveform can be estimated,what's more,the ratio of signal to noise of detecting weak random binary code can be achieved-25dB below,and the computer simulation verifies effectiveness of the method.As a result,the research in the paper provides the a feasible and efficient method of weak random binary code detection under the conditions of Strong noise background",
        "keywords": [
            "weak signal detection",
            "stochastic resonance",
            "random binary code",
            "noise",
            "two-dimensional bistable"
        ],
        "authors": [
            {
                "name": "Wu Danhui",
                "org": "College of Electronics and Electrical Engineering,Shan'Xi University of Science and Technology,Xi'an ,China"
            },
            {
                "name": "Yang Ping",
                "org": "College of Electronics and Electrical Engineering,Shan'Xi University of Science and Technology,Xi'an ,China"
            }
        ],
        "venue": "Computer Measurement & Control",
        "year": 2010
    },
    "IsGPcYUC": {
        "id": "IsGPcYUC",
        "title": "Research on Relationship of Chaos Attractor with Chaos Synchronization System",
        "abstract": "The basic form of Duffing equation is firstly analyzed;and then,it describes the principle of weak signal detection based on the change of phase trace;the method of expressing Chaotic attractor by ways of bond wave and spiral in Chua circuit is presented,and then,a bond wave synchronization system based on Chua circuit is designed;an application is put forward,which detects weak signal utilizing chaos bond wave synchronization system,the critical problems existing in weak signal detection based on chaos can be solved.The research provides the foundation of putting chaos bond wave synchronization system into practice application to weak signal detection.",
        "keywords": [
            "weak signal detection",
            "chaotic attractor",
            "Chua circuit",
            "Duffing equation",
            "bond-wave synchronization"
        ],
        "authors": [
            {
                "name": "Wu Danhui",
                "org": "College of Electronics and Electrical Engineering,Shan'Xi University of Science and Technology,Xi'an ,China"
            },
            {
                "name": "Zhang Yujie",
                "org": "College of Electronics and Electrical Engineering,Shan'Xi University of Science and Technology,Xi'an ,China"
            },
            {
                "name": "Yang Ping",
                "org": "College of Electronics and Electrical Engineering,Shan'Xi University of Science and Technology,Xi'an ,China"
            }
        ],
        "venue": "Computer Measurement & Control",
        "year": 2008
    },
    "FSblc6H9": {
        "id": "FSblc6H9",
        "title": "Application of DDS Technology in Sine Wave Function Generator",
        "abstract": "Function generator plays more and more important role in automatic measure.DDS can easily control signal frequency in order to synthesize the wave directly.C8051F040 MCU of the Cygnal enterprise is used,in order to control the circuit.AD9850 of the DDS chip is used to generate the sine wave.Meanwhile,frequency data of external input can be transformed to frequency phase control words of chip by simple parallel or serial communication with MCU.In view of universality,function generator with the core of high speed MCU uses the chips of DDS and FPGA.On the basis of generating routine sine wave,it can modulate signal frequency and range.At the same time function generator can generate binary PSK and ASK signal.",
        "keywords": [
            "DDS",
            "MCU",
            "function generator",
            "FPGA"
        ],
        "authors": [
            {
                "name": "Yang Ping",
                "org": "1.College of Electronic and Information,Shaanxi University of Science and Technology,Xianyang ,China,"
            },
            {
                "name": "Wu Danhui",
                "org": "1.College of Electronic and Information,Shaanxi University of Science and Technology,Xianyang ,China,"
            },
            {
                "name": "Yang Liangyu",
                "org": "2.School of Electric and Control Engineering,Xi'an University of Science and Technology,Xi'an ,China"
            }
        ],
        "venue": "Computer Measurement & Control",
        "year": 2008
    },
    "j1e8sa5Q": {
        "id": "j1e8sa5Q",
        "title": "Flow Patterns Identification of Air-water Two-phase Based on Improved BP Neural Network",
        "abstract": "Air\u2014water two\u2014phase flow can be divided into stratified flow,churn flow,slug flow and annular flow according to its flow patterns.Differential pressure signal of the two\u2014phase flow is measured.The probability density function(PDF) is used to extract the characters of the differential pressure signal.Four characteristic parameters of the PDF,the peak number K_1,the maximum peak value K_2,the peak position K_3,and the PDF variance K_4 are defined.The characteristic vectors consisted of the four defined parameters are used to train the BP neural network in order to identify the flow regimes.Results show this method has accurate identification.So it is a new method for flow patterns identification.",
        "keywords": [
            "PDF",
            "flow patterns identification",
            "BP neural network"
        ],
        "authors": [
            {
                "name": "Yang Ping",
                "org": "College of Electric and Information,Shaanxi University of Science and Technology,Xi'an ,China"
            },
            {
                "name": "Yang Liangyu",
                "org": "School of Electric and Control Engineering,Xi'an University of Science and Technology,Xi'an ,China"
            },
            {
                "name": "Zhang Yujie",
                "org": "College of Electric and Information,Shaanxi University of Science and Technology,Xi'an ,China"
            }
        ],
        "venue": "Computer Measurement & Control",
        "year": 2009
    },
    "VwGiIimk": {
        "id": "VwGiIimk",
        "title": "Influence of Dingxin Recipe and Tanshinone\u2161A on IL-6 Level in Rat Model of Myocardial Ischemia/Reperfusion Injury",
        "abstract": "Objective:To investigate the effects of Dingin recipe(DXR) and tanshinone \u2161A(Tan) on serum interleukin-6(IL-6) content in rat model of myocardial ischemia/reperfusion injury(MI/RI),and explore their mechanism of myocardial protection.Methods: Thirty-two male Wistar rats were randomly divided into four groups(8 in each):sham operation group(group SH),model group,group DXR and group Tan.MI/RI model was established by ligating left anterior descending branch of coronary artery.During the process,electrocardiogram was taking continuously to observe arrhythmias,and the serum level of IL-6 was measured by ELISA.At the same time,HE staining was performed to detect the pathological change in myocardium.Results: Serum IL-6 contents were lower and MI/RI was lightened significantly in groups DXR and Tan.Conclusions: Dingxin recipe and Tanshinone\u2161A can decrease expression of IL-6 and pathological change of myocardium and reduce arrhythmia and inflammatory response after MI/RI in rats.These actions may contribute to the protective effect on the ischemic myocardial cells.",
        "keywords": [
            "Dingxin recipe",
            "myocardial ischemia",
            "interleakin-6",
            "rats",
            "myocardial reperfusion injury",
            "wistar",
            "tanshinone\u2161A"
        ],
        "authors": [
            {
                "name": "LI Lijun",
                "org": "School of TCM,Southern Medical University,Guangzhou ,Guangdong,China"
            },
            {
                "name": "JIA Yuhua",
                "org": "School of TCM,Southern Medical University,Guangzhou ,Guangdong,China"
            },
            {
                "name": "SUN Xuegang",
                "org": "School of TCM,Southern Medical University,Guangzhou ,Guangdong,China"
            },
            {
                "name": "LI Jie",
                "org": "School of TCM,Southern Medical University,Guangzhou ,Guangdong,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of TCM,Southern Medical University,Guangzhou ,Guangdong,China"
            },
            {
                "name": "ZHOU Fenghua",
                "org": "School of TCM,Southern Medical University,Guangzhou ,Guangdong,China"
            }
        ],
        "venue": "Journal of Guiyang Medical College",
        "year": 2010
    },
    "auRrOQJG": {
        "id": "auRrOQJG",
        "title": "The Protective Mechanism of Salvia Polysaccharides against Myocardial Cell Injury Induced by H_2O_2",
        "abstract": "Objective To study the expression of prohibitin in oxidative stress myocardial cells induced by H2O2 and regulation of Salvia polysaccharides on it. Methods Use H2O2 to stimulate the primary cultured myocardial cells to establish cellular oxidative stress model;to check cell viability by MTT assay;flow cytometry was used to detect cell apoptosis;the expression of prohibitin was detected by western boltting. Results Compared with the model group,Salvia polysaccharide groups significantly increased cell viability and decreased the apoptosis ratio,especially the high dose group(P<0.01);the expression of prohibitin was low in normal myocardial cells,while higher in the model group;SM polysaccharide treatment groups obviously increased its level,especially the high dose group;there was significantly difference compared with the model group(P<0.05). Conclusion Salvia polysaccharides can protect myocardial cell injury induced by H2O2 by up-regulating the expression of prohibitin.",
        "keywords": [
            "Salvia polysaccharides",
            "Apoptosis",
            "Oxidative stress",
            "Myocardial cells"
        ],
        "authors": [
            {
                "name": "Zhou Feng-hua",
                "org": "School of Traditional Chinese Medicine of Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "LI Li-jun",
                "org": "School of Traditional Chinese Medicine of Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "LI Jie",
                "org": "School of Traditional Chinese Medicine of Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Traditional Chinese Medicine of Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "JIA Yu-hua",
                "org": "School of Traditional Chinese Medicine of Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "SUN Xue-gang",
                "org": "School of Traditional Chinese Medicine of Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Lishizhen Medicine and Materia Medica Research",
        "year": 2011
    },
    "odX54K5Z": {
        "id": "odX54K5Z",
        "title": "Protective Effect of Tanshinone \u2161A on Myocardial Damage Induced by Hydrogen Peroxide and its Mechenism",
        "abstract": "Objective To study the protective effect and mechanism of Tanshinone \u2161A on myocardial damage induced by hydrogen peroxide.Methods Primary cultured neonate rat myocardial cell was cultured in medium with 200\u03bcmol/L hydrogen peroxide,and the medium was supplemented with different concentrations of Tanshinone \u2161A in advance.Cell viability was determined by MTT method.Annexin V/PI bivariate dyeing was used to detect apoptosis rate.Besides,T-AOC,LDH,MDA,SOD,GSH-Px,CAT were detected to evaluate cell antioxidant ability.Results In model group,cell viability decreased significantly and apoptosis rate rose significantly compared with normal group.Compared with model group,Tanshinone \u2161A increased cell viability and decreased apoptosis rate in a dose-dependent manner.Compared with normal group,LDH and MDA increased remarkably,and T-AOC,SOD,GSH-Px,CAT were dropped remarkably in model group.Compared with model group,Tanshinone \u2161A decreased LDH and MDA significantly,and increased T-AOC,SOD,GSH-Px,CAT significantly in a dose-dependent manner.Conclusion Tanshinone \u2161A can reduce myocardial damage induced by hydrogen peroxide,the mechanism may be related with the enhancement antioxidase activity,and decrease of lipid peroxidation.",
        "keywords": [
            "Tanshinone \u2161A",
            "Oxidative stress",
            "Myocardial cell"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "LI Jie",
                "org": "Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "ZHOU Feng-hua",
                "org": "Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "LI Li-jun",
                "org": "Southern Medical University,Guangzhou ,China"
            },
            {
                "name": "JIA Yu-hua",
                "org": "Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Lishizhen Medicine and Materia Medica Research",
        "year": 2010
    },
    "2w8dy5fV": {
        "id": "2w8dy5fV",
        "title": "Effect of DingXin Recipe on MAPK Pathway of Myocardial Ischemia Reperfusion Injury in Rats",
        "abstract": "Objective:To study effect of DingXin Recipe on MAPK pathway of myocardial ischemia reperfusion Injury in Rats. Methods:40 wistar rats were randomly divided to five groups :sham operation group,model group,low dose \u3001middle dose and high dose DingXin Recipe groups. The model of myocardial ischemia reperfusion in rats were established by ligating the left coronary arteries for 15min and then loosing for 30min. The expression of pERK1/2,pJNK1/2,pP38 were detected by western blotting. Arrhythmia was scored according to \u2161-lead ECG. Results:Compared with model group,The level of pJNK1/2 and pP38 and arrhythmia score was significantly decreased ( P < 0. 05). The level of pERK1/2 was higher in DingXin Recipe groups than other groups ( P <0. 001) ,and sham operation group was same with modle group( P >0. 05). Conclusion:Myocardial ischemia reperfusion injury can be alleviate. The mechanisms may be that MAPK pathway was influenced by DingXin Recipe.",
        "keywords": [
            "DingXin Recipe",
            "mitogen-activated protein kinase",
            "myocardial ischemia reperfusion"
        ],
        "authors": [
            {
                "name": "LI Jie",
                "org": " Traditional Chinese Medicine College,Southern Medical University,Guangzhou ,Guangdong,China"
            },
            {
                "name": "JIA Yu-hua",
                "org": " Traditional Chinese Medicine College,Southern Medical University,Guangzhou ,Guangdong,China"
            },
            {
                "name": "YANG Ping",
                "org": " Traditional Chinese Medicine College,Southern Medical University,Guangzhou ,Guangdong,China"
            },
            {
                "name": "LI Li-jun",
                "org": " Traditional Chinese Medicine College,Southern Medical University,Guangzhou ,Guangdong,China"
            },
            {
                "name": "ZHOU Feng-hua",
                "org": " Traditional Chinese Medicine College,Southern Medical University,Guangzhou ,Guangdong,China"
            }
        ],
        "venue": "Liaoning Journal of Traditional Chinese Medicine",
        "year": 2009
    },
    "3sDwhWcj": {
        "id": "3sDwhWcj",
        "title": "Anti-oxidative Effect of Tanshinone \u2161_A and Prohibitin in Cardiomyocytes",
        "abstract": "Objective:To study the anti-apoptotic mechanism of tanshinone\u2161A and the function of prohibitin(PHB) on myocardial cell apoptosis induced by hydrogen peroxide(H2O2).Method:there were six groups of myocardial cells in the study:normal control group,oxidative stress group,tanshinone\u2161A group,siRNA group,siRNA + oxidative stress group,siRNA control group.Primary cultured neonate rat myocardial cells were cultured in medium with 200 \u03bcmol\u00b7L-1 hydrogen peroxide,and the medium was supplemented with tanshinone\u2161A(1 \u00d7 10-4,5 \u00d7 10-5,1 \u00d7 10-5 mol\u00b7L-1) in advance for 24 hours.PHB in myocardial cells was knocked down by small interfering RNA(siRNA) interference,and the expression level of PHB was determined by western blotting analysis.Flow cytometric analysis was used to detect apoptosis rate,[Ca2 + ]i and mitochondrial membrane potential(MMP).Result:H2O2-mediated cell apoptosis resulted in activation of PHB,increasing of [Ca2+ ]i,and decreasing of mitochondrial membrane potential.Tanshinone IIA profoundly prohibited myocardial cells apoptosis induced by hydrogen peroxide,and decreased [Ca2 + ]i,and increased mitochondrial membrane potential in a dose dependent manner.Specific silence of PHB by siRNA down-regulated the expression level of PHB and increased ofapoptosis rate and [Ca2 + ]i,and decreased mitochondrial membrane potential.Conclusion:The results demonstrated that the activation of PHB is compensatory increased in myocardial cells against oxidative stress.tanshinone \u2161A could reduce the expression of PHB by attenuate the injury induced by oxidative stress.",
        "keywords": [
            "prohibitin",
            "tanshinone \u2161A",
            "calcium overload",
            "myocardial cell",
            "oxidative stress"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Nanchang Hospital of Integrated Traditional and Western Medicine,Nanchang ,China"
            },
            {
                "name": "JIA Yu-hua",
                "org": "\u21692.Southern Medical University,Guangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Experimental Traditional Medical Formulae",
        "year": 2011
    },
    "kxEeps5F": {
        "id": "kxEeps5F",
        "title": "Expression of EPOR in Ischemia-reperfusion Injured Myocardium and Intervention Effect of Tanshinone \u2161A",
        "abstract": "Objective:To study the expression of EPOR in ischemia-reperfusion injured myocardium and the regulation mechanism,and the intervention effect of tanshinone \u2161A.Methods:Rats were randomly divided into four groups:sham operation group,model group,PDTC group,tanshinone \u2161A group.Experimental animal model was conducted by ligating and loosening left anterior descending coronary.Arrhythmia score,infarct size,and the expression of EPOR and NF-\u03baB were compared in the three groups.The expressions of EPOR and NF-\u03baB were determined by immunohistochemical staining.Results:The expressions of EPOR and NF-\u03baB in model group were significantly higher than that in sham operation group(P<0.01),and the expression of NF-\u03baB was significantly decreased after the pre-treatment of PDTC or tanshinone \u2161A,while the expression of EPOR increased significantly(P<0.01).Conclusion:Myocardial ischemia-reperfusion injury could lead to high expression of EPOR,inhibit the expression of NF-\u03baB and enhance the expression of EPOR.Tanshinone \u2161A could regulate the expression of EPOR,its mechanism may be related to prevention of the inflammatory reaction induced by NF-\u03baB.",
        "keywords": [
            "Tanshinone \u2161A",
            "EPOR",
            "NF-\u03baB",
            "myocardial ischemia-reperfusion"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Nanchang Hospital of Integrated Traditional Chinese and Western Medicine,Nanchang ,Jiangxi,China"
            },
            {
                "name": "ZHOU Yu-ping",
                "org": "Nanchang Hospital of Integrated Traditional Chinese and Western Medicine,Nanchang ,Jiangxi,China"
            }
        ],
        "venue": "Liaoning Journal of Traditional Chinese Medicine",
        "year": 2012
    },
    "KPtcnFmH": {
        "id": "KPtcnFmH",
        "title": "Liposomes-mediated chemosynthesis siRNA transfection to primary cardiomyocytes: Selection of an ideal concentration",
        "abstract": "BACKGROUND: siRNA transfection is a key step in RNA interference. The methods of cardiomyocytes transfection were most use of plasmids as vector to transfect long-chain shRNA. However, the processes were complex. It was a simple efficient and low-toxic method that liposomes-mediated chemosynthesis siRNA transfection. It was useful for expanding RNA interference application. OBJECTIVE: To choice the optimal concentration of liposomes-mediated chemosynthesis siRNA transfection, and to discover a simple efficient RNA interference application. METHODS: CY3-Negative siRNA was mediated by lipid-based agent siPORT\u2122 NeoFX\u2122 to transfect cardiomyocytes. A blank control group was set. After 24 hours, the transfection efficiency and apoptotic rate were evaluated by fluorescent microscope and flow cytometer to select an optimal concentration. Based the best concentration, siRNA PHB was transfected to cardiomyocytes. 48 hours later, the expression of PHB was tested. RESULTS AND CONCLUSION: With the increased concentration of CY3-Negative siRNA, the number of cells emitted red fluorescence grew under fluorescence microscope, and the transfection efficiency was also increased (P < 0.05). The best concentration was 30 nmol/L (P < 0.05). There was no significant difference in apoptotic rate between transfected groups and the control group (P > 0.05). The PHB expression of cardiomyocytes transfected siRNA PHB was dropped by 74.11% on average (P < 0.05). The results indicated that lipid based agent siPORT\u2122 NeoFX\u2122 was suitable to transfect chemosynthesis siRNA to cardiomyocytes and the best transfection concentration of siRNA was 30 nmol/L.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Jie Li",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Jia Yu-hua",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Ping Yang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Zhou Feng-hua",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Li Li-jun",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            }
        ],
        "venue": "Journal of Clinical Rehabilitative Tissue Engineering Research",
        "year": 2010
    },
    "0RmyQQTK": {
        "id": "0RmyQQTK",
        "title": "A Study of Anti-apoptosis Effect and Mechanism of Tanshinone \u2161A in Hydrogen Peroxide Damaged Myocardial Cell",
        "abstract": "Objective:To study protective effect and mechanism of Tanshinone \u2161A on damage induced by hydrogen peroxide in myocardial cell. Methods:Primary cultured neonate rat myocardial cell was cultured in medium with 200\u03bcmol/L hydrogen peroxide,and the medium was supplemented with different concentrations of Tanshinone \u2161A in advance. Apoptosis rate,[Ca2 + ]i and mitochondrial membrane potential was determined by flow cytometric analysis. Besides,Na + -K + -ATPase and Ca2 + -Mg2 + -ATPase was also evaluated in each group. Results:In model group,apoptosis rate rose significantly compared with normal group. Comparing with model group,Tanshinone \u2161A decreased apoptosis rate in a dose dependent manner. Comparing with normal group,[Ca2 + ]i was increased remarkably,while mitochondrial membrane potential,Na + -K + -ATPase and Ca2 + -Mg2 + -ATPase dropped remarkably in model group. Comparing with model group,Tanshinone \u2161A decreased [Ca2 + ]i significantly,and increased mitochondrial membrane potential,Na + -K + -ATPase and Ca2 + -Mg2 + -ATPase significantly in a dose dependent manner. Conclusion:Tanshinone \u2161A could attenuate apoptosis induced by hydrogen peroxide,the mechanism may be that Tanshinone \u2161A could enhance Na + -K + -ATPase and Ca2 + -Mg2 + -ATPase activity,and thus reduce intracellular free calcium.",
        "keywords": [
            "Calcium overload",
            "Tanshinone \u2161A",
            "Apoptosis",
            "Oxidative stress",
            "Myocardial cell"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": " Southern Medical University,Guangzhou ,Guangdong,China"
            },
            {
                "name": "LI Jie",
                "org": " Southern Medical University,Guangzhou ,Guangdong,China"
            },
            {
                "name": "LI Li-jun",
                "org": " Southern Medical University,Guangzhou ,Guangdong,China"
            },
            {
                "name": "ZHOU Feng-hua",
                "org": " Southern Medical University,Guangzhou ,Guangdong,China"
            }
        ],
        "venue": "Liaoning Journal of Traditional Chinese Medicine",
        "year": 2009
    },
    "o0OqU83L": {
        "id": "o0OqU83L",
        "title": "Effects of Tanshinone \u2161A on Arrhythmia and Levels of Ischemia Modified Albumin and Heart Type Fatty Acid Binding Protein in Rats with Myocardial Ischemia-reperfusion Injury",
        "abstract": "Objective To observe the effect of tanshinone\u2161A (T\u2161A) on arrhythmia and levels of ischemia modified albumin (IMA) and heart type-fatty acid binding protein (H-FABP) in rats with myocardial ischemia-reperfusion injury.Methods Forty Wistar rats were equally randomized into 5 groups:pseudo-operation group (normal saline),model group (normal saline),and high-,middle-and low-dose T\u2161A groups (in the dose of 20,10 and 5 mg\u00b7kg-1\u00b7d-1 respectively).The rats were treated for 7 days,and received operation 2 hours after the last medication.Rats in pseudo-operation group received threading without ligation,while animal model of myocardial ischemia-reperfusion injury was established by ligating the left-anterior coronary artery for 15 minutes and then loosening for 30 minutes.During the operation,electrocardiogram was traced continuously to observe the arrhythmia.HE staining was used to observe the pathological changes of myocardium.Levels of IMA and H-FABP in myocardium were determined by enzyme-linked immunosorbent assay (ELISA).Results Ischemic changes of the myocardium and arrhythmia occurred,myocardial IMA level increased and H-FABP level decreased in the model rats.Tanshinone\u2161A obviously attenuated arrhythmia caused by ischemia-reperfusion injury (P < 0.05),relieved the pathology changes in myocardium,decreased IMA level and increased H-FABP level.The difference of IMA level between high-and middle-dose T\u2161A groups and the model group was significant (P < 0.05).So did the difference of H-FABP level between high-dose T\u2161A group and the model group (P < 0.05).Conclusion Tanshinone\u2161A has a protective effect against arrhythmia in rats with myocardial ischemia-reperfusion injury,which can inhibit the increase of IMA and the decrease of H-FABP after the injury.",
        "keywords": [
            "Rats",
            "Ischemia-reperfusion injury",
            "Arrhythmia",
            "Heart type-fatty acid binding protein(H-FABP)",
            "Iischemia modified albumin (IMA)",
            "Tanshinone\u2161A"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Southern Medical University,Guangzhou,China"
            },
            {
                "name": "JIA Yuhua",
                "org": "Southern Medical University,Guangzhou,China"
            },
            {
                "name": "LI Jie",
                "org": "Southern Medical University,Guangzhou,China"
            }
        ],
        "venue": "Traditional Chinese Drug Research & Clinical Pharmacology",
        "year": 2009
    },
    "BePcjDzO": {
        "id": "BePcjDzO",
        "title": "Application of Metabonomic Technology into the Study of Traditional Chinese Medicine",
        "abstract": "Metabolomics,a new subject that develops following genomics,transcriptomics and proteomics,is a important part of systems biology.It is considered the final direction of the study of systems biology.The metabolic products may vary from one TCM syndrome to another.Application of metabonomic technology could promote the study of the essence of TCM syndrome,and make TCM be scientific and quantitative.Besides,metabonomic technology will also contribute to the evaluation of the comprehensive effect,as well as the the material basis and the safety of TCM compounds,which will establish a scientific methods for drugs quality control of traditional Chinese,and make these drugs safety and effective.",
        "keywords": [
            "Syndrome",
            "Traditional Chinese Drugs",
            "Traditional Chinese Medicine",
            "Metabonomics"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Southern Medical University,Guangzhou ,Guangdong,China"
            },
            {
                "name": "JIA Yu-hua",
                "org": "Southern Medical University,Guangzhou ,Guangdong,China"
            },
            {
                "name": "LI Jie",
                "org": "Southern Medical University,Guangzhou ,Guangdong,China"
            }
        ],
        "venue": "Liaoning Journal of Traditional Chinese Medicine",
        "year": 2009
    },
    "JfX0bPHs": {
        "id": "JfX0bPHs",
        "title": "Association of serum uric acid and function of blood vessel endothelium in hypertensive patients",
        "abstract": "Objective Through the detection of serum uric acid(SUA) and flow-mediated endothelium-dependent vasodilatation(FMD) for Hypertensive patients,we want to study the correlation between them and significance.Methods Select 48 hypertensive patients in Cardiovascular department of CJUH of Jilin University as hypertension group,39 people that took health examination as the control group FMD and NMD were used as the detecting index of endothelial function.In addition,we divided hypertension group into normal UA group and hyperuricemia group.The focal point is studying the correlation between SUA and FMD in hypertensive patients.Results SUA of hypertension group and the control group is respectively(363.69\u00b190.27) \u03bcmol/L and(303.32\u00b199.27) \u03bcmol/L,between the two groups with significant difference,p=0.004.Brachial artery diameter change percent of normal SUA group and hyperuricemia group is respectively(10.27\u00b14.79)% and(6.17\u00b12.37)%,between the two groups with significant difference,P<0.05.NMD of the two group is respectively(14.19\u00b16.45)% and(10.75\u00b13.52)%,there's no significant difference between them,P>0.05.In patients who is high blood pressure level 1\u30012\u30013,the mean of FMD of normal uric acid group respectively is 12.84%\u300110.89% and 6.29%;the mean of FMD of hyperuricemia group respectively is 7.04%\u30016.39% and 5.41%.FMD descending with the increasing of the ranking of the high blood pressure;FMD of the same ranking blood pressure descending with the increasing of SUA.SUA is negative correlation with FMD(r=-0.325),P<0.05.Conclusion Level of SUA of hypertension group is higher than the control group.SUA correlates with injury of FMD.FMD descending with the increasing of SUA.",
        "keywords": [
            "Serum uric acid",
            "Blood vessel endothelium",
            "Hypertension"
        ],
        "authors": [
            {
                "name": "HE Yu-quan",
                "org": "Department of cardiology,China-Japan Union Hospital of Jinlin University,Changchun ,China"
            },
            {
                "name": "LI Di",
                "org": "Department of cardiology,China-Japan Union Hospital of Jinlin University,Changchun ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of cardiology,China-Japan Union Hospital of Jinlin University,Changchun ,China"
            }
        ],
        "venue": "Chinese Journal of Laboratory Diagnosis",
        "year": 2010
    },
    "D6G0lUkm": {
        "id": "D6G0lUkm",
        "title": "Ghrelin protects H9c2 cardiomyocytes from angiotensin II-induced apoptosis through the endoplasmic reticulum stress pathway.",
        "abstract": "Ghrelin, a gastric hormone, exerts cardioprotective function by increasing myocardial contractility and vasodilation. Previous studies have reported that angiotensin II (Ang II) production increased in heart failure, which can induce cardiomyocyte apoptosis. In this study, we investigated the effect of ghrelin on Ang II-induced H9c2 cardiomyocyte apoptosis. The results showed that Ang II inhibited H9c2 cell viability, which was blocked by ghrelin. By annexin V-propidium iodide dual staining and 2'-deoxyuridine 5'-triphosphate nick end-labeling analysis, we found that Ang II induced H9c2 cell apoptosis, whereas coincubation of ghrelin with Ang II significantly reduced H9c2 cell apoptosis induced by Ang II. Simultaneously, the results revealed that ghrelin regulated the Ang II-induced imbalance of Bax and Bcl-2 expression and reduced Ang II-induced caspase-3 expression. Moreover, mRNA expressions of endoplasmic reticulum stress-related molecules GRP78, caspase-12, and C/EBP homologous protein were significantly upregulated by Ang II. However, their expressions were significantly inhibited by ghrelin. In addition, we found that ghrelin markedly inhibited Ang II-induced Ang II type 1 receptor expression. These data suggest that ghrelin may play an antagonistic role in Ang II-induced cardiomyocyte apoptosis via decreasing Ang II type 1 receptor expression and inhibiting the activation of endoplasmic reticulum stress pathway.",
        "keywords": [
            "apoptosis",
            "ghrelin",
            "angiotensin ii",
            "h9c2 cells",
            "endoplasmic reticulum stress"
        ],
        "authors": [
            {
                "name": "Chunyan Yang",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Yinan Wang",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Haiyan Liu",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Nan Li",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Yang Sun",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Zhonghui Liu",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Ping Yang",
                "org": "Jilin University(Jilin University),Changchun,China"
            }
        ],
        "venue": "Journal of cardiovascular pharmacology",
        "year": 2012
    },
    "6ziJek3h": {
        "id": "6ziJek3h",
        "title": "Red yeast rice repairs kidney damage and reduces inflammatory transcription factors in rat models of hyperlipidemia.",
        "abstract": "Xuezhikang (XZK), an extract of red yeast rice, has been widely used for the management of hyperlipidemia and coronary heart disease (CHD); however, the effects of XZK treatment on kidney injury have not yet been fully identified. The aim of the current study was to evaluate the effects of XZK on the kidneys and investigate the related mechanisms in a rat model of hyperlipidemia. Thus, the effect on inflammatory transcription factors and kidney damage was investigated with in vitro and in vivo experiments on hyperlipidemic rats following XZK treatment. The results revealed that the plasma levels of total cholesterol (TC), triglycerides (TG) and low-density lipoprotein-cholesterol (LDL-C) were significantly decreased, while the levels of high-density lipoprotein-cholesterol (HDL-C) were significantly upregulated in the XZK treatment group, as compared with those in the hyperlipidemia group (P&amp;lt;0.05). In addition, the results demonstrated that XZK was able to repair the kidney damage caused by hyperlipidemia. Furthermore, the expression levels of the inflammatory transcription factors, tumor necrosis factor-\u03b1 and interleukin-6, were shown to be reduced in the XZK group when compared with the hyperlipidemia group. In summary, XZK reduces kidney injury, downregulates the levels of TG, TC and LDL-C, as well as the expression levels of inflammatory transcription factors, and upregulates HDL-C. These results further the understanding of the molecular pathogenic mechanisms underlying hyperlipidemia and aid the development of XZK as an effective therapeutic agent for hyperlipidemia.",
        "keywords": [
            "hyperlipidimia",
            "interleukin-6",
            "kidney function",
            "tumor necrosis factor-\u03b1",
            "xuezhikang",
            "cell",
            "gene",
            "oncology",
            "apoptosis",
            "cell cycle",
            "cancer",
            "molecular medicine",
            "bioinformatics",
            "biomedical research"
        ],
        "authors": [
            {
                "name": "Mei Ding",
                "org": "Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China."
            },
            {
                "name": "Daoyuan Si",
                "org": "Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China."
            },
            {
                "name": "Wenqi Zhang",
                "org": "Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China."
            },
            {
                "name": "Zhaohui Feng",
                "org": "Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China."
            },
            {
                "name": "Min He",
                "org": "Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China."
            },
            {
                "name": "Ping Yang",
                "org": "Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China."
            }
        ],
        "venue": "Experimental and therapeutic medicine",
        "year": 2014
    },
    "Ohp1XOBv": {
        "id": "Ohp1XOBv",
        "title": "GW27-e0933 MicroRNA Profile and Regulatory Roles in Post-infarction Heart Failure",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Liu Xueyan",
                "org": "China-Japan Union Hospital of Jilin University, Changchun, China"
            },
            {
                "name": "Ping Yang",
                "org": "China-Japan Union Hospital of Jilin University, Changchun, China"
            }
        ],
        "venue": "Journal of the American College of Cardiology",
        "year": 2016
    },
    "AK6PJnSj": {
        "id": "AK6PJnSj",
        "title": "Experimental study about ranolazine treatment on vivo myocardial ischemia-reperfusion arrhythmia in guinea pig",
        "abstract": "Objective:To investigate ranolazine in guinea pig in vivo ischemia-reperfusion model of arrhythmia and its mechanism.Method:Application of guinea pig in vivo myocardial ischemia-reperfusion model,we observed the ranolazine on SOD,MDA,impact of reperfusion arrhythmias.Result:Ranolazine can enhance the SOD activity and reduce the level of MAD can be against ischemia-reperfusion injury in the process,reducing reperfusion arrhythmia.Conclusion:Ranolazine can scavenge oxygen free radicals and reduce or eliminate the lipid peroxidation and reduced reperfusion arrhythmia.",
        "keywords": [
            "myocardial ischemia-reperfusioninjury",
            "arrhythmia",
            "ranolazine"
        ],
        "authors": [
            {
                "name": "WANG Guotao",
                "org": "Department of Cardiology the Fourth Hospital of Daqing,Daqing,Heilongjiang,,China"
            },
            {
                "name": "ZHANG Wenjie",
                "org": "Department of Physiology,Basic Medicine College,Jilin University"
            },
            {
                "name": "YANG Ping",
                "org": "China-Japan Union Hospital of Jilin University"
            }
        ],
        "venue": "Journal of Clinical Cardiology",
        "year": 2011
    },
    "crPHQrY8": {
        "id": "crPHQrY8",
        "title": "Detection of platelet activation marker and blood clotting activity in patients with hypertension and its clinical significance",
        "abstract": "Objective: To investigate the changes of molecule markers of pre-thrombotic state, expression of CD62P, concentration of plasma fibrinogen (Fib), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) in the patients with essential hypertension for providing theoretical evidence for diagnosis and therapy of thrombus complication in early clinical stage. Methods: Fifty-three patients with hypertension (grade I 17 cases, grade II 16 cases, grade III 20 cases) were selected and twenty-eight people with medical examination in good health were used as control group. The expressions of CD62P and CD61 were measured by flow cytometry. The concentration of Fib and the levels of PT, APTT, TT were measured by Class coagulation method. Results: The expression of CD62P and the concentration of plasma Fib in essential hypertension group were higher than those in control groups (P<0.01). The levels of PT, APTT, TT in essential hypertension group were lower than those in control groups (P<0.05). The expressions of CD62P in essential hypertension grade II and III groups were obviously higher than that in essential hypertension grade I group (P<0.01). The concentration of plasma Fib in essential hypertension grade III groups was significantly higher than those in essential hypertension grade I and II groups (P<0.01). The levels of PT, APTT, TT in essential hypertension grade II and III groups were obviously lower than those in essential hypertension grade I group (P<0.05). There was no difference of the expression of CD61 between any groups (P>0.05). Conclusion: The essential hypertensive patients are in pre-thrombotic state, the activation of platelet and blood clotting activity increase. Molecular markers should be measured in essential hypertensive patients for prevention and treatment of thrombotic disease.",
        "keywords": [
            "CD62P",
            "Fibrinogen",
            "Hypertension",
            "Platelet activation",
            "Prethrombotic state"
        ],
        "authors": [
            {
                "name": "Li Yang",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Yuan Wu",
                "org": "Ningxia People's Hospital(Ningxia People's Hospital),,China"
            },
            {
                "name": "Ping Yang",
                "org": "Jilin University(Jilin University),Changchun,China"
            }
        ],
        "venue": "Journal of Jilin University(Medicine Edition)",
        "year": 2009
    },
    "ae9aj8uU": {
        "id": "ae9aj8uU",
        "title": "The impact of microRNA-122 and its target gene Sestrin-2 on the protective effect of ghrelin in angiotensin II-induced cardiomyocyte apoptosis",
        "abstract": "Ghrelin with n-octanoylated serine 3 residue is a peptide hormone with well-known cardioprotective properties. MicroRNA-122 is associated with the pathogenesis of many cardiovascular diseases, including apoptosis and was found highly increased in our previous rat model of post-myocardial infarction heart failure. In this study, we aimed to identify the target gene of microRNA-122 and to evaluate their impacts on the protective effect of acylated ghrelin in angiotensin II-induced apoptosis. The results showed that microRNA-122 was upregulated in the angiotensin II administration group accompanied by increased cell apoptosis, which were both reversed by ghrelin. Furthermore, microRNA-122 mimics upregulated numerous pro-apoptotic genes and increased apoptosis. The luciferase activity assay revealed Sestrin-2 as a direct target of microRNA-122. The expression of Sestrin-2 was downregulated by angiotensin II and upregulated by co-treatment with ghrelin. Inhibition of microRNA-122 and overexpression of Sestrin-2 alleviated apoptosis which was further reduced upon administered of ghrelin. Together, these results indicated that Sestrin-2 expression is inhibited by microRNA-122 and that this inhibition is involved in the protective effect of ghrelin and angiotensin II-induced apoptosis. We also found that microRNA-122 influenced several apoptosis pathways including the caspase cascade reaction and death receptor-mediated pathways. Collectively, our data reveal that microRNA-122 and its target gene Sestrin-2, under the regulation of angiotensin II and ghrelin, are important players in cardiomyocyte apoptosis. We therefore believe that microRNA-122 and Sestrin-2 can be developed as potential therapeutic targets against apoptosis in cardiovascular diseases.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaotong Wang",
                "org": "The Department of Cardiology, China-Japan Union Hospital, Jilin University,Changchun,China"
            },
            {
                "name": "Chunyan Yang",
                "org": "The Department of Cardiology, China-Japan Union Hospital, Jilin University,Changchun,China"
            },
            {
                "name": "Xueyan Liu",
                "org": "The Department of Cardiology, China-Japan Union Hospital, Jilin University,Changchun,China"
            },
            {
                "name": "Ping Yang",
                "org": "The Department of Cardiology, China-Japan Union Hospital, Jilin University,Changchun,China"
            }
        ],
        "venue": "RSC Advances",
        "year": 2018
    },
    "y8hYHC2E": {
        "id": "y8hYHC2E",
        "title": "Inhibition effects of sodium ferulate to over-production of smooth muscle cell by ox-LDL induced",
        "abstract": "Objective To discuss the inhibition effects of sodium ferulate(SF) to over-production of smooth muscle cell(SMC) by ox-LDL induced.Methods Patch-attaching method for culture of arterial SMC were adapted,after passaged the SMCs were divided into 5 groups,in ox-LDL group 100 mg/L ox-LDL was added,in SF groups 25,50,100 mg/ml SF were added variedly and 2 h befor 100 mg/L ox-LDL added,only normal culture liquid were added in control group.For all the groups the MTT and flow cytometry were applied to evaluation the production of SMCs.Results The primary SMCs look like long spin or triangle and can be passaged at least 10-12 generation.The production of ox-LDL SMCs were higher significantly than the control group(P<0.01),and compared with ox-LDL group,SF groups increased significantly(P<0.01,P<0.05).Compared with control group,the number of SMCs in ox-LDL group were decreased in G0/G1 phase and increased in S and G2/M phase,the difference is signifiant(P<0.01).Compared with ox-LDLgroup,the number of SMCs in SF group were increased in G0/G1 phase and decreased in S and G2/M phase,the difference is signifiant(P<0.01).Conclusion SF can inhibited the over-production effects of SMC induced by ox-LDL,witch may be helpful for the treatment for AS.",
        "keywords": [
            "Atherosclerosis",
            "sodium ferulate",
            "smooth muscle cells",
            "Cell Cycle"
        ],
        "authors": [
            {
                "name": "JIANG Tie-chao",
                "org": "China-Japan Union Hospital of Jilin University,Changchun,China"
            },
            {
                "name": "WANG Zhuo-yue",
                "org": "China-Japan Union Hospital of Jilin University,Changchun,China"
            },
            {
                "name": "YANG Ping",
                "org": "China-Japan Union Hospital of Jilin University,Changchun,China"
            }
        ],
        "venue": "Chinese Journal of Laboratory Diagnosis",
        "year": 2010
    },
    "LExdHE5j": {
        "id": "LExdHE5j",
        "title": "Daily 10\u200amg rivaroxaban as a therapy for ventricular thrombus related to left ventricular non-compaction cardiomyopathy: A case report.",
        "abstract": "Low dose of rivaroxaban may serve as a viable option for anticoagulation therapy in LVNC patients, with large clinical trials needed to determine the best course of treatment.",
        "keywords": "",
        "authors": [
            {
                "name": "Huan Sun",
                "org": "Cardiology Department."
            },
            {
                "name": "Qini Zhao",
                "org": "Cardiology Department."
            },
            {
                "name": "Yanjing Wang",
                "org": "Radiology Department, China-Japan Union Hospital of Jilin University, Changchun, China."
            },
            {
                "name": "Robert Lakin",
                "org": "Department of Exercise Sciences, University of Toronto, Toronto, Ontario, Canada."
            },
            {
                "name": "Haiyan Feng",
                "org": "Ultrasound Department, China-Japan Union Hospital of Jilin University, Changchun, China."
            },
            {
                "name": "Xingyu Fan",
                "org": "Cardiology Department."
            },
            {
                "name": "Huiling Luo",
                "org": "Cardiology Department."
            },
            {
                "name": "Dongmei Gao",
                "org": "Ultrasound Department, China-Japan Union Hospital of Jilin University, Changchun, China."
            },
            {
                "name": "Lin Liu",
                "org": "Radiology Department, China-Japan Union Hospital of Jilin University, Changchun, China."
            },
            {
                "name": "Yuquan He",
                "org": "Cardiology Department."
            },
            {
                "name": "Ping Yang",
                "org": "Cardiology Department."
            }
        ],
        "venue": "Medicine",
        "year": 2018
    },
    "Tkej20kK": {
        "id": "Tkej20kK",
        "title": "Quantitative evaluation of anti-ischemic effect of isosorbide dinitrate for intravenous infusion",
        "abstract": "Objective To evaluate the anti-ischemic effect of isosorbide dinitrate(ISDN) quantitatively.(Methods 36 patients) were divided into three group according to the different time points after the start of ISDN infused intravenously:group\u2160(30 min),group \u2161(60 min),group \u2162(150 min).()~(99m)Tc-MIBI myocardial perfusion SPECT images was used to evaluate directly the anti-ischemic effect of ISDN on 36 patients with coronary heart disease.The changes in the percentage of ischemia area in entire left ventricular area and ECG were determined by the unfolded surface mapping before and after ISDN infusion.Results()~(99m)Tc-MIBI myocardial perfusion SPECT images were acquired,and reconstruction of the bull\u2032s eye map and unfolded surface mapping were performed according to the dates of tomography images.In group\u2160: at the 65% threshold value,(33.01\u00b15.35)% at baseline,(28.9\u00b15.23)% after ISDN was infused(P<0.05);at the 55% threshold value,(22.06\u00b15.58)% at baseline,(19.60\u00b14.07)% after ISDN was infused(P<0.05);the sum of ischemia ST segments was 60 at baseline,51 after ISDN was infused.In group \u2161:at the 65% threshold value,(29.20\u00b15.08)% at baseline,(20.81\u00b14.16)% after ISDN was infused(P<0.001);at the 55% threshold value,(21.2\u00b15.49)% at baseline,(17.52\u00b15.59)% after ISDN was infused(P<0.001);the sum of ischemia ST segments was 58 at baseline,(47 after) ISDN was infused.In group \u2162: at the 65% threshold value,(32.87\u00b16.46)% at baseline,(20.81\u00b14.16)% after ISDN was infused(P<0.001);at the 55% threshold value,(18.42\u00b15.17)% at baseline,(14.18\u00b13.61)% after ISDN was infused(P<0.001);the sum of ischemia ST segments was 64 at baseline,41 after ISDN was infused.Conclusion The unfolded surface mapping of()~(99m)Tc-MIBI myocardial perfusion image can be used as a method of quantitative evaluation of the anti-ischemic effect of drugs and ISDN iv drip can improve the blood flow in myocardium and myocardial perfusion.",
        "keywords": [
            "tomography",
            "unfolded surface mapping",
            "myocardial ischemia",
            "single photo",
            "emission computed",
            "isosorbide dinitrate",
            "technetium Tc 99m sestamibi"
        ],
        "authors": [
            {
                "name": "MENG Fan-bo",
                "org": "Department of Cardiology,China-Japan Union Hospital,Jilin University,Changchun ,China"
            },
            {
                "name": "JIA Jie",
                "org": "Department of Ultrasonic Diagnosis,China-Japan Union Hospital,Jilin University,Changchun ,China"
            },
            {
                "name": "XU Wen-gui",
                "org": "Department of PET,Tumor Hospital of Tianjin,Tianjian ,China"
            },
            {
                "name": "SUN Ping-hui",
                "org": "Department of Epidemiology and Statistics,School of Public Health,Jilin University,Changchun ,China"
            },
            {
                "name": "GUO Jin-rui",
                "org": ""
            },
            {
                "name": "YANG Ping",
                "org": "Department of Cardiology,China-Japan Union Hospital,Jilin University,Changchun ,China"
            },
            {
                "name": "WANG Wen-zhi",
                "org": "Department of Cardiology,China-Japan Union Hospital,Jilin University,Changchun ,China"
            }
        ],
        "venue": "Journal of Jilin University(Medicine Edition)",
        "year": 2006
    },
    "d3JHGtKY": {
        "id": "d3JHGtKY",
        "title": "Evaluation of curative effects of Qiliqiangxin capsule in treatment of patients with chronic congestive heart failure",
        "abstract": "Objective: To study the clinical effect of Qiliqiangxin capsule (QC) in patients with chronic congestive heart failure (CHF). Methods: According to random number table, 64 CHF patients were randomly assigned into therapy group (n=33) and control group (n=31). During the treatment, sweat secretion, heart function improved rate, 6 min walking distance, the side-effect and compliance were observed. The levels of serum Na+ and K+ of patients were measured on the 2nd, 8th and 15th hospital day. Results: Compared with control group, the remission rate of sweat secretion in therapy group was higher after treatment (P<0.05). One week later, heart function and 6 min walking distance were improved in both groups, but there was no significant difference between two groups (P>0.05); compared with control group, the improved rates of heart function and 6 min walking distance in therapy group were higher after two weeks (P<0.05). There was no significant difference between two groups of the level of serum Na+ on the 8th hospital day (P>0.05); on the 15th day, the level of serum Na+ in therapy group was higher than that in control group (P<0.05). There were no significant differences between two groups of the level of serum K+ on the 8th or 15th hospital day (P>0.05). During treatment, 33 patients had not any uncomfortable complain about this drug and nobody stopped using this capsule; while there was no complain from the patients of control group. Conclusion: The effect of QC about releasing hyperidrosis in a short time is conspicuous. QC can improve heart function, but it plays this role gradually. QC can keep the level of serum Na+ to some extent. There is no influence on the level of serum K+. The tolerance of this capsule is well.",
        "keywords": [
            "Electrolyte disturbances",
            "Heart failure",
            " congestive",
            "Hyponatremia",
            "Qiliqiangxin capsule"
        ],
        "authors": [
            {
                "name": "Mei Ding",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Ping Yang",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Min He",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "FENG Zhao-hui",
                "org": "Jilin University(Jilin University),Changchun,China"
            }
        ],
        "venue": "Journal of Jilin University(Medicine Edition)",
        "year": 2009
    },
    "1ZfQvUpC": {
        "id": "1ZfQvUpC",
        "title": "Expressions of nitric oxide and plasminogen activator inhibitor type-1 in rabbit models of atherosclerosis and interference effect of atorvastatin",
        "abstract": "Objective To investigate the expressions of nitric oxide (NO) and plasminogen activator inhibitor type-1(PAI-1)in rabbit models of atherosclerosis and the interference effect of atorvastatin. Methods Twenty four male Japanese rabbits were divided into 3 groups (8 in each group): high-fat diet group(group A),high-fat plus atorvastatin group (group B) and normal diet group(group C).The expressions of NO and PAI-1 were detected with ELISA assay.Plasma lipid was detected with automatic analysis divice. Results The espression of NO in group B was significantly higher than those in groups A and group C (P<0.01); there was no significant difference between groups A and C (P>0.05).The expression of PAI-1 in group B was significantly lower than those in groups A and C,there was no significant difference between groups A and group C (P>0.05).The levels of serum TC in groups A,B,and C were (23.51\u00b110.58),(14.27\u00b13.51)and(1.36\u00b10.33)mmol\u00b7L-1, respectively; the levels of serum LDL in groups A,B,and C were (21.39\u00b110.00),(14.23\u00b14.01)and(0.72\u00b10.35)mmol\u00b7L-1;there were significant differences between three groups (P<0.05),while TG had no significant difference between three groups (P>0.05).Conclusion High-fat diet has no significant effect on the expressions of NO and PAI-1 in atherosclerosis rabbits .Atorvastatin can increase the expression of NO and decrease the expression of PAI-1,and can inhibit the progression of atherosclerosis.",
        "keywords": [
            "nitric oxide",
            "atorvastatin",
            "atherosclerosis",
            "plasminogen activator inhibitor type-1"
        ],
        "authors": [
            {
                "name": "YANG Yu-shuang",
                "org": "Department of Cardiology,China-Japan Union Hospital,Jilin University,Changchun ,China"
            },
            {
                "name": "LI Xue-yu",
                "org": "Department of Cardiology,China-Japan Union Hospital,Jilin University,Changchun ,China"
            },
            {
                "name": "MA Wei",
                "org": "Department of Cardiology,China-Japan Union Hospital,Jilin University,Changchun ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Cardiology,China-Japan Union Hospital,Jilin University,Changchun ,China"
            }
        ],
        "venue": "Journal of Jilin University(Medicine Edition)",
        "year": 2007
    },
    "dXwhmp7b": {
        "id": "dXwhmp7b",
        "title": "Ghrelin Alleviates Angiotensin II-Induced H9c2 Apoptosis: Impact of the miR-208 Family.",
        "abstract": "BACKGROUND Ghrelin is a novel peptide with abundant cardioprotective effects. The miR-208 family, consisting of cardiac-specifically expressed microRNAs, are not only involved in hypertrophy and fibrosis, but are also closely related with myocyte apoptosis. This study explored the role of the miR-208 family in the protective effect of ghrelin on angiotensin II (Ang II)-induced apoptosis. MATERIAL AND METHODS H9c2 cells were exposed to Ang II with or without ghrelin. Cell viability was detected by MTT assay and the percentage of apoptotic cells was confirmed by flow cytometry. miRNAs expression levels were measured by qRT-PCR. Then, cells transfected with miR-208 negative control, mimics, and inhibitors were treated with Ang II and ghrelin, followed by flow cytometry. PCR array was performed to explore the pathways affected by miR-208. RESULTS The miR-208 level was reduced in Ang II-treated H9c2 cells, accompanied with increased cell apoptosis, which were both reversed by ghrelin administration. Flow cytometry revealed that miR-208 inhibitors clearly upregulated the apoptotic percentage, whereas miR-208 mimics showed the opposite effects in the Ang II group. miR-208a further alleviated apoptosis when treated with ghrelin. miR-208 mainly affected caspase, inflammatory-related genes, and several signaling pathways. CONCLUSIONS We provide new evidence that the miR-208 family is regulated by Ang II and ghrelin. Overexpression of miR-208 family alleviated Ang II-induced cell apoptosis and miR-208a assisted in the protective effect of ghrelin. Several apoptosis pathways affected by miR-208 family were found. These findings suggest the pathogenesis of cardiomyocyte apoptosis and the protective mechanism of ghrelin.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaotong Wang",
                "org": "Department of Cardiololgy, China-Japan Union Hospital, Jilin University, Changchun, Jilin, China (mainland)."
            },
            {
                "name": "Chunyan Yang",
                "org": "Department of Cardiology, China-Japan Union Hospital, Jilin University, Changchun, Jilin, China (mainland)."
            },
            {
                "name": "Xueyan Liu",
                "org": "Department of Cardiology, China-Japan Union Hospital, Jilin University, Changchun, Jilin, China (mainland)."
            },
            {
                "name": "Ping Yang",
                "org": "Department of Cardiology, China-Japan Union Hospital, Jilin University, Changchun, Jilin, China (mainland)."
            }
        ],
        "venue": "Medical science monitor : international medical journal of experimental and clinical research",
        "year": 2018
    },
    "fcghWDy1": {
        "id": "fcghWDy1",
        "title": "Imaging diagnosis for left ventricular thrombosis in idiopathic hypereosinophilic syndrome: two case reports.",
        "abstract": "Idiopathic hypereosinophilic syndrome (IHES) is a rare disease that is frequently associated with cardiac thrombosis and endocardial wall thickness. This case report describes 2 patients who had IHES associated with left ventricular (LV) thrombi. The patients' symptoms are atypical. Peripheral blood and bone marrow tests showed markedly elevated eosinophils. Electrocardiography showed ischemic changes in both patients. Negative computed tomography (CT) angiography excluded coronary artery stenosis. Transthoracic echocardiography (TTE), conventional multislice spiral CT, gemstone spectral CT, and cardiac magnetic resonance imaging were used to identify the LV intraluminal thrombus and endocardial thickening, and the diagnostic values of each imaging method were analyzed and compared. These patients were clinically diagnosed as \"IHES, LV thrombosis, NYHA heart function classification I.\" Both patients received oral prednisone and warfarin therapy. At 5 month follow-up, TTE rechecks showed that the size of the LV thrombotic lesion was reduced in the first case but substantially increased in the second case.",
        "keywords": [],
        "authors": [
            {
                "name": "Yu-Quan He",
                "org": "Division of Cardiology (Y-QH, Y-NZ, J-MZ, HZ, PY); and Division of Radiology (M-CZ, LL), China-Japan Union Hospital of Jilin University, Changchun, Jilin, China."
            },
            {
                "name": "Ya-Nan Zhao",
                "org": ""
            },
            {
                "name": "Jin-Ming Zhu",
                "org": ""
            },
            {
                "name": "Meng-Chao Zhang",
                "org": ""
            },
            {
                "name": "Lin Liu",
                "org": ""
            },
            {
                "name": "Hong Zeng",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            }
        ],
        "venue": "Medicine",
        "year": 2014
    },
    "KyBJHqCH": {
        "id": "KyBJHqCH",
        "title": "Effect of atorvastatin and coenzyme Q10 on the contents of free fatty acid and ATP in heart failure rats after acute myocardial infarction",
        "abstract": "Objective To investigate the metabolic remodeling effects of atorvastatin and coenzyme Q10 on experimental heart failure in rats after myocardial infarction(MI).Methods The rat model of heart failure was established by left anterior descending coronary artery deligation.After 6 w,24 surviving rats were divided into sham,model,atorvastatin group and atorvastatin+coenzyme groups at random,6 rats in each,and were treated with medicines by intragastric administration respectively.At 12 w,the level of serum free fatty acid(FFA) and the content of ATP in the noninfarcted area of the left ventricle were measured.Results Atorvastatin association with coenzyme Q10 increased the content of ATP,whereas decreased the level of FFA in serum(P<0.05).Conclusions Atorvastatin association with coenzyme Q10 has retrieve energy metabolism disturbance FFA and ATP to improve metabolic remodeling on heart failure after AMI in rats.",
        "keywords": [
            "Heart failure",
            "FFA",
            "ATP",
            "Atorvastatin",
            "Coenzyme Q10"
        ],
        "authors": [
            {
                "name": "ZHAO Dong-Ming",
                "org": ",et al. Department of Cardiology,China-Japan Union Hospital,Jilin University,Changchun ,Jilin,China"
            },
            {
                "name": "YANG Ping",
                "org": ",et al. Department of Cardiology,China-Japan Union Hospital,Jilin University,Changchun ,Jilin,China"
            },
            {
                "name": "YANG Jie",
                "org": ",et al. Department of Cardiology,China-Japan Union Hospital,Jilin University,Changchun ,Jilin,China"
            }
        ],
        "venue": "Chinese Journal of Gerontology",
        "year": 2013
    },
    "85v3EWzJ": {
        "id": "85v3EWzJ",
        "title": "Characterizing fast pathway in typical and atypical atrioventricular nodal re-entrant tachycardia by atrial-His and His-atrial: more to consider.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Huan Sun",
                "org": "Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, China."
            },
            {
                "name": "Robert Lakin",
                "org": "Department of Exercise Sciences, University of Toronto, Toronto, ON, Canada."
            },
            {
                "name": "Yuquan He",
                "org": "Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, China hyq2@sina.com."
            },
            {
                "name": "Ping Yang",
                "org": "Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, China."
            }
        ],
        "venue": "Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology",
        "year": 2015
    },
    "oPgtNTPw": {
        "id": "oPgtNTPw",
        "title": "GW29-e1085 Red yeast rice repairs kidney damage and reduces inflammatory transcription factors in rat models of hyperlipidemia",
        "abstract": "Xuezhikang (XZK), an extract of red yeast rice, has been widely used for the management of hyperlipidemia and coronary heart disease (CHD); however, the effects of XZK treatment on kidney injury have not yet been fully identified. The aim of the current study was to evaluate the effects of XZK on",
        "keywords": "",
        "authors": [
            {
                "name": "Mei Ding",
                "org": "China Japan Union Hospital of Jilin University"
            },
            {
                "name": "Ping Yang",
                "org": ""
            }
        ],
        "venue": "Journal of the American College of Cardiology",
        "year": 2018
    },
    "rUpvBnxn": {
        "id": "rUpvBnxn",
        "title": "Inhibition of periostin by qiliqiangxin to improve ventricular remodeling in heart failure rats",
        "abstract": "Objective We investigated the effect of qiliqiangxin,a traditional Chinese medicine,on periostin mRNA expression in myocardial tissue to establish a therapy to prevent left ventricular remodeling in heart failure rats after myocardial infarction (MI).Methods We randomized 28 rats surviving left anterior descending coronary artery ligation to placebo,ramipril,qiliqiangxin-large dosage,and qiliqiangxin-small dosage therapy with 8 other mice being sham.At 8 weeks,we measured regional infarct zone (IZ) periostin by RT-PCR,and Plasma angiotensin \u2161 (Ang \u2161) concentration by an ELISA kit.Results Compared with ramipril,large dosage qiliqiangxin treatments exerted more powerful effect on attenuation of plasma Ang \u2161(P<0.05).But there were no significant differences in periostin mRNA expressions between these two groups (P>0.05).However,small dosage qiliqiangxin treatment exerted less powerful effects on periostin mRNA expressions while there were no significant differences between small dosage qiliqiangxin and ramipril in plasma Ang \u2161 concentration (P>0.05).Conclusion The attenuation of periostin by qiliqiangxin treatment in a dosage dependent manner,is an important mechanism for improvement of ventricular remodeling in heart failure after MI.",
        "keywords": [
            "left ventricular remodeling",
            "periostin",
            "angiotensin",
            "qiliqiangxin"
        ],
        "authors": [
            {
                "name": "LI Jia-yu",
                "org": "Department of Cardiology,Chin-Japan Union Hospital of Jilin University,Changchun ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Cardiology,Chin-Japan Union Hospital of Jilin University,Changchun ,China"
            }
        ],
        "venue": "Chinese Journal of Laboratory Diagnosis",
        "year": 2009
    },
    "6MBJ8GDb": {
        "id": "6MBJ8GDb",
        "title": "The effects of amlodipine and S(-)-amlodipine on vascular endothelial function in patients with hypertension",
        "abstract": "Background Amlodipine has been shown to improve vascular endothelial function in hypertensive patients, but whether S(-)-amlodipine has a similar effect remains controversial. This study compared the effects of amlodipine and S(-)-amlodipine on vascular endothelial function in hypertensive patients and investigated relevant mechanisms of action in cell culture. methods Twenty-four patients with essential hypertension received amlodipine and S(-)-amlodipine for 6 weeks in a randomized, crossover study. Associated flow-mediated dilation (FMD), nitric oxide (NO), and endothelial nitric oxide synthase (eNOS) levels were determined. NO levels were measured after exposure of human umbilical vein endothelial cells (HUVECs) to amlodipine, S(-)-amlodipine, the eNOS inhibitor N w-nitro-L-arginine (L-NA), and the Protein Kinase C (PKC) inhibitor Ro 31-8220. Phosphorylation levels of Ser1177 and Thr495 in eNOS were determined after exposure to amlodipine, S(-)-amlodipine, and Ro 31-8220. results FMD, NO, and eNOS levels significantly improved after treatment with amlodipine and S(-)-amlodipine. The levels were all higher with amlodipine, although the between-treatment difference was not statistically significant. Amlodipine and S(-)-amlodipine significantly increased NO levels in cultured HUVECs, but increases in NO levels were more marked with amlodipine. Western blot assay showed that both amlodipine and Ro31-8220 induced Ser1177 phosphorylation and weakened Thr495 phosphorylation in eNOS. S(-)-amlodipine had no similar effects. Amlodipine, but not S(-)-amlodipine, decreased the PKC phosphorylation in a time-dependent manner. conclusions Amlodipine and S(-)-amlodipine can both improve endothelial function in hypertensive patients. Amlodipine has greater potential for vascular endothelial protection than S(-)-amlodipine. It affects eNOS phosphorylation at Ser 1177 and Thr495 by the PKC pathway, further enhancing eNOS activation. ? American Journal of Hypertension, Ltd 2013.",
        "keywords": [
            "Amlodipine",
            "Blood pressure",
            "Doppler ultrasonography",
            "Endothelial function",
            "Hypertension",
            "Phosphorylation",
            "S(-)-amlodipine"
        ],
        "authors": [
            {
                "name": "Daoyuan Si",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Yuquan He",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Chunyan Yang",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Lujia Ni",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Bing Li",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Mei Ding",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Ping Yang",
                "org": "Jilin University(Jilin University),Changchun,China"
            }
        ],
        "venue": "American Journal of Hypertension",
        "year": 2014
    },
    "F7B2WywJ": {
        "id": "F7B2WywJ",
        "title": "Influencing Factors and Clinical Implications of Left Atrial Size",
        "abstract": "Left atrial(LA)size is a common clinical index reflecting the geometrical shape of heart.LA enlargement has been proposed as a barometer of diastolic burden and a predictor of common cardiovascular outcomes.In this review,we outline the methods for assessing LA size and function using echocardiography.Then,we review the determinants of LA size and remodelling,and finally we describe the evidence regarding the prognostic value of LA size.We show that using LA volume for risk stratification of cardiovascular events will become possible,and result in earlier treatment of cardiovascular problems,thereby improving outcomes.",
        "keywords": [
            "cardiovascular events",
            "left atrial size"
        ],
        "authors": [
            {
                "name": "LI Ying",
                "org": "Cardiovascular Department,Sino-Japan Union Hospital of Jilin University,Changchun ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Cardiovascular Department,Sino-Japan Union Hospital of Jilin University,Changchun ,China"
            }
        ],
        "venue": "Advances in Cardiovascular Diseases",
        "year": 2008
    },
    "W7K5NJqr": {
        "id": "W7K5NJqr",
        "title": "Effect of immunoglobulin on the expressions of IL-6,TNF-\u03b1 in heart failure rats after acute myocardial infarction",
        "abstract": "Objective To investigate the effects of immunoglobulin(IVIG) on the levels of IL-6,TNF-\u03b1 and BNP in heart failure rats after acute myocardial infarction(AMI).Methods The rat models of heart failure were established by left anterior descending coronary artery deligation.After 6 w,15 rats were divided into model and IVIG groups at random,in addition,sham-operated group was selected,and were treated with medicines by intraperitoneal injection respectively.At 11 w,the levels of serum IL-6,TNF-\u03b1 and BNP were observed.Results The levels of IL-6,TNF-\u03b1 and BNP of model groups were increased significantly,IVIG decreased significantly the levels of IL-6,TNF-\u03b1 and BNP.Conclusions IVIG can reduce the contents of inflammatory factors in heart failure rats after AM I,it also reduce the content of BNP,which may be related to improving heart function.",
        "keywords": [
            "TNF-\u03b1",
            "Heart failure",
            "IL-6",
            "Immunoglobulin(IVIG)"
        ],
        "authors": [
            {
                "name": "YANG Jie",
                "org": ".Department of Endocrinology,China-Japan Union Hospital of Jilin University,Changchun ,Jilin,China"
            },
            {
                "name": "YANG Ping",
                "org": ".Department of Endocrinology,China-Japan Union Hospital of Jilin University,Changchun ,Jilin,China"
            },
            {
                "name": "HUAI Shu-Jun",
                "org": ".Department of Endocrinology,China-Japan Union Hospital of Jilin University,Changchun ,Jilin,China"
            }
        ],
        "venue": "Chinese Journal of Gerontology",
        "year": 2011
    },
    "lxvLP8en": {
        "id": "lxvLP8en",
        "title": "The Expression of PPAR-\u03b3 in a Rabbit Model of Atherosclerosis and The Effect of Telmisartan",
        "abstract": "Objective To investigate the expression of peroxisome proliferator-activated receptor-\u03b3(PPAR-\u03b3) in a rabbit model of atherosclerosis,and the effect of telmisartan.Methods 32 male Japanese rabbits were separated in 4 groups(8 in each group),which were high-fat diet group(group A),high-fat plus telmisartan group(group B),high-fat plus losarten group(group C)and normal diet group(group D).All the animals were sacrificed after 16 weeks.The expression of PPAR-\u03b3 was detected with immunohistochemical assay,and plasma lipid with automatic biochemical analysis device.Results The expression of PPAR-\u03b3 in group A and group B had significant differences compared with group C and group D,but there wasn't any significant differences(P>0.05) between group A and B.Conclusion The expression of PPAR-\u03b3augmented in a rabbit model of atherosclerosis which affected by many factors;Telmisartan may be have the effect increased the expression of PPAR-\u03b3",
        "keywords": [
            "Atherosclerosis",
            "Lipid",
            "Telmisartan",
            "PPAR-gamma"
        ],
        "authors": [
            {
                "name": "HE Yu-quan",
                "org": "Department of Cardiology,the Second Hospital of Jilin University,Changchun ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Cardiology,the Second Hospital of Jilin University,Changchun ,China"
            },
            {
                "name": "ZHU Jin-ming",
                "org": "Department of Cardiology,the Second Hospital of Jilin University,Changchun ,China"
            }
        ],
        "venue": "Chinese Journal of Laboratory Diagnosis",
        "year": 2007
    },
    "bqrPcAfl": {
        "id": "bqrPcAfl",
        "title": "Active immunization with norovirus P particle-based amyloid-\u03b2 chimeric protein vaccine induces high titers of anti-A\u03b2 antibodies in mice.",
        "abstract": "The untagged A\u03b21-6 chimeric protein vaccine is safe and highly immunogenic. Further research will determine the efficacy in cognitive improvement and disease progression delay.",
        "keywords": [
            "Active immunization",
            "Alzheimer\u2019s disease",
            "Amyloid-\u03b2",
            "Norovirus P particle",
            "Protein vaccine"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130012, China."
            },
            {
                "name": "Yongqing Guo",
                "org": "National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130012, China."
            },
            {
                "name": "Yao Sun",
                "org": "National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130012, China."
            },
            {
                "name": "Bin Yu",
                "org": "Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China."
            },
            {
                "name": "Haihong Zhang",
                "org": "Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China."
            },
            {
                "name": "Jiaxin Wu",
                "org": "Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China."
            },
            {
                "name": "Xianghui Yu",
                "org": "Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China."
            },
            {
                "name": "Hui Wu",
                "org": "Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China. topwuhui@jlu.edu.cn."
            },
            {
                "name": "Wei Kong",
                "org": "Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China. weikong@jlu.edu.cn."
            }
        ],
        "venue": "BMC immunology",
        "year": 2019
    },
    "WnOtkcfT": {
        "id": "WnOtkcfT",
        "title": "Effect of atorvastatin and coenzyme Q10 on the expression of uncoupling proteins-2 in heart failure rats after acut myocardial infarction",
        "abstract": "Objective To investigate the antioxidation effects of atorvastatin and coenzyme Q10 on experimental heart failure in rats after myocardial infarction(MI).Methods The rat model of heart failure was established by left anterior descending coronary artery deligation.After 6 weeks,24 surviving rats were divided into sham,model,atorvastatin group and atorvastatin+coenzyme group at random,6 rats in each,and were treated with medicines by intragastric administration respectively.At 12 weeks,we measured left ventricular end-diastolic pressure(LVEDP),left ventricular systolic pressure(LVSP),+dp/dtmax and-dp/dtmax of left ventricular pressure,the activity of serum superoxide dismutase(SOD) and the content of serum malondialdehyde(MDA) were quantified.The heart weight(HW)and left ventricular heart weight(LVHW)were weighed.HW/ BW and LVHW/BW were calculated.Furthermore,the mRNA levels of UCP2 were detected by RT-PCR in noninfarction zone.Results Atorvastatin association with coenzyme Q10 increased \u00b1dp/dtmax(P<0.05\uff5e0.01)and the activity of serum superoxide dismutase,whereas decreased significantly LVSP and LVEDP,the content of MDA in serum,myocardial hypertrophy index,downregulated the mRNA expressiones of UCP2 in noninfarction zone(P<0.05\uff5e0.001).But no influence on HR,SBP and DBP(P>0.05).Conclusion Atorvastatin association with coenzyme Q10 has improve energy metabolism by downregulating the mRNA expressiones of UCP2 on heart failure after AMI in rats,which may be related to scavenging the oxygen free radicals formed.",
        "keywords": [
            "atorvastatin coenzyme Q10 heart failure uncoupling proteins 2"
        ],
        "authors": [
            {
                "name": "ZHAO Dong-ming",
                "org": "Department of cardiology,China-Japan Union Hospital,Jilin University,Changchun ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of cardiology,China-Japan Union Hospital,Jilin University,Changchun ,China"
            }
        ],
        "venue": "Chinese Journal of Laboratory Diagnosis",
        "year": 2011
    },
    "N50oNz8F": {
        "id": "N50oNz8F",
        "title": "Effects of Trimetazidine on Cardiac Function and free radical metabolism in Rats with Ischemic Heart Failure",
        "abstract": "Objective To investigate the effects of trimetazidine on cardiac function in rats with ischemic heart failure.Methods We established ischemic heart failure rats by the left coronary artery ligation.30 rats after operation were separated randomized into 3 groups.Trimetazidine was given intervention within 24 hours after surgery in one group(TI group) and after 4 weeks in another group(TF group).The 3rd group was heart failure control group(F group).After 8 weeks we observed the cardiac index,hemodynamic changes of each groups compared with the sham group(S group),and SOD,MDA changes in each groups.Results Trimetazidine was significantly improved cardiac function compared to F group.and significantly aggrandized the activity of SOD,reduced content of MDA(P<0.01).The improvement was more significant in TI group.Conclusion Trimetazidine can improve heart function in rats with ischemic heart failure,and the effect is more obvious in early stage.",
        "keywords": [
            "Heart Failure",
            "Trimetazidine",
            "Cardiac Function"
        ],
        "authors": [
            {
                "name": "MA Pi-yong",
                "org": "Emergency Department of China-Japan Union Hospital,Jilin University,Changchun ,China"
            },
            {
                "name": "LI Jia-yu",
                "org": "Emergency Department of China-Japan Union Hospital,Jilin University,Changchun ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Emergency Department of China-Japan Union Hospital,Jilin University,Changchun ,China"
            }
        ],
        "venue": "Chinese Journal of Laboratory Diagnosis",
        "year": 2011
    },
    "2nAzvA0f": {
        "id": "2nAzvA0f",
        "title": "Evaluation on efficacy and safety of tolvaptan in treatment of hyponatremia in patients with chronic heart failure",
        "abstract": "Objective To observe the clinical efficacy of tolvaptan in treatment of hyponatremia in patients with chronic heart failure(CHF)and to evaluate its efficacy and safety.Methods 16 patients with CHF and hyponatremia were randomly divided into therapy group(conventional treatment+tolvaptan,8cases)and control group(conventional treatment,8cases).All the patients were evaluated by observing the serum sodium,serum sodium,urine volume and body weight 8and 24hafter treatment with double-blind control method,and Minnesota Living with Heart Failure Questionnaire(MLHFQ)was performed 8dafter treatment,and the adverse reactions were observed.Results The levels of serum sodium of the patients in therapy group 8and 24hafter treatment were significantly higher than those in control group(P<0.01).The urine volume of the patients in therapy group 24hafter treatment was increased compared with before treatment(P<0.05),but there was no significant difference between therapy group and control group(P>0.05).The MLHFQ of the patients in two groups 8d after treatment were significantly improved compared with before treatment(P<0.01),the improvement in therapy group was more significant compared with control group(P<0.05).There were no adverse events,and only 1case of dry mouth was found in therapy group.Conclusion The efficacy of tolvaptan in treatment of the patients with CHF and hyponatremia is better,and it can improve their qualities of life with good safety and tolerability.",
        "keywords": [
            "tolvaptan",
            "chronic heart failure",
            "hyponatremia"
        ],
        "authors": [
            {
                "name": "LI Bing",
                "org": ""
            },
            {
                "name": "HE Min",
                "org": ""
            },
            {
                "name": "TONG Ya-liang",
                "org": ""
            },
            {
                "name": "FENG Zhao-hui",
                "org": ""
            },
            {
                "name": "YANG Ping",
                "org": ""
            }
        ],
        "venue": "Journal of Jilin University(Medicine Edition)",
        "year": 2013
    },
    "OvFVt9ka": {
        "id": "OvFVt9ka",
        "title": "Antifibrotic effect of Qiliqiangxin capsule in the scar tissues of heart failure rats after myocardial infarction",
        "abstract": "Objective To investigate the effect of Qiliqiangxin capsule,a traditional Chinese medicine,on collagen remodeling in infarct zone(IZ)tissue to establish a therapy in heart failure rats after myocardial infarction(MI).Methods 56 heart failure model rats induced by left anterior descending coronary artery ligation were fed for 4 w and randomized into heart failure model,ramipril,Qiliqiangxin capsule large and small dosage groups,in addition,sham-operated group was selected.After drug intervention for 4 w,the expression of collagen \u2160 mRNA was detected by RT-PCR,and total collagen level was determined by hydroxyproline assay.Results The expression of collagen \u2160 mRNA and total collagen level were significantly reduced in each drug group(P<0.05).The therapeutic effect of Qiliqiangxin capsule large dosage group was similar as that of ramipril group(P>0.05),but superior to that of Qiliqiangxin capsule small dosage group(P<0.05).Conclusions Qiliqiangxin capsule could obviously decrease further collagen synthesis and maturation in infarction zone and descend scar fibrosis in a dosage dependent manner during the progression of heart failure after MI.",
        "keywords": [
            "Collagen \u2160",
            "Hydroxyproline",
            "Fibrosis",
            "Qiliqiangxin"
        ],
        "authors": [
            {
                "name": "LI Jia-Yu",
                "org": ".China-Japan Union Hospital of Jilin University,Changchun ,Jilin,China"
            },
            {
                "name": "YANG Ping",
                "org": ".China-Japan Union Hospital of Jilin University,Changchun ,Jilin,China"
            }
        ],
        "venue": "Chinese Journal of Gerontology",
        "year": 2009
    },
    "SfiNE8FA": {
        "id": "SfiNE8FA",
        "title": "Comparative analysis of bind energies and sites between simvastatin and atorvastatin into CYP3A4",
        "abstract": "The three-dimensional (3D) models of simvastatin and atorvastatin into CYP3A4 enzyme were constructed based on the crystal structure (PDB ID:3UA1) and refined by molecular dynamics simulations. The results showed that simvastatin and atorvastatin can stably bound into the active site of CYP3A4 enzyme. The hydrogen bonds and hydrophobic interactions played an important role in the stabilities of the conformation of the complexes. The interactions between simvastatin, atorvastatin and CYP3A4, as well as anchor amino acid residues for substrates binding were discussed. In addition, the potential dehydrogenated site by CYP3A4 of simvastatin and atorvastatin site was pointed out, which was in agreement with the experiment in vivo.",
        "keywords": [
            "Atorvastatin",
            "Molecular docking",
            "Molecular dynamics simulation",
            "Simvastatin"
        ],
        "authors": [
            {
                "name": "Tiechao Jiang",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Ning Kong",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Shanshan Zhao",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Ping Yang",
                "org": "Jilin University(Jilin University),Changchun,China"
            }
        ],
        "venue": "Asian Journal of Chemistry",
        "year": 2013
    },
    "qAJj9Fkr": {
        "id": "qAJj9Fkr",
        "title": "Clinical curative effect observation of Tongxinluo Capsule combined with Shensongyangxin Capsule in the treatment of ischemic heart disease combined with ventricular premature beat in 86 cases",
        "abstract": "Objective To discuss the clinical efficacy of Tongxinluo Capsule combined with Shensongyangxin Capsule in the treatment of ischemic heart disease combined with ventricular premature beat.Methods Eighty six cases of patients diagnosed with ischemic heart disease were divided into two groups.44 cases in the treatment group were given oral Tongxinluo Capsule,4 tablets each time,3 times a day;Shensongyangxin Capsule,4 tablets each time,3 times a day.42 cases in control group were given oral isosorbide dinitrate,10 mg each time,3 times a day;mxiletine 0.2 g each time,3 times a day.Course of treatment was both one month.Results The total effectiveness in the treatment group was 95.45%,which was 85.71% in the control group the treatment group,was better than the control group.The difference was statistically significant (P < 0.05).Conclusion The effect of Tongxinluo Capsule combined with Shensongyangxin Capsule in the treatment of ischemic heart disease combined with ventricular premature beat is good,and there is no cardiac adverse reaction occurred during the treatment.",
        "keywords": [
            "Shensongyangxin Capsule",
            "Ischemic heart disease",
            "Ventricular premature beat",
            "Tongxinluo Capsule"
        ],
        "authors": [
            {
                "name": "ZHANG Shuxia",
                "org": "Department of Cardiology,the First People's Hospital of Tongyu County in Jilin Province,Tongyu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Cardiology,Sino-Japanese Fellowship Hospital of Jilin University,Changchun ,China"
            }
        ],
        "venue": "China Modern Medicine",
        "year": 2012
    },
    "qBRetBiv": {
        "id": "qBRetBiv",
        "title": "Effects of ranolazine on action potential and contraction force in guinea pig papillary muscles",
        "abstract": "Objective To observe the effects of ranolazine on the action potential and contraction force in guinea pig papillary muscles,Explore the mechanism of ranolazine anti-arrhythmia and myocardial ischemia.Methods Eighteen healthy adult guinea-pigs were randomly divided into H2O2(200 mmol \u00b7L-1)groups\u3001ranolazine(10 mmol \u00b7L-1)+H2O2 groups and TTX(2 mmol \u00b7L-1)+H2O2 groups,with six guinea pigs in every group compared with themselves before administration to observe the effects of ranolazine on the papillary muscles.Results H2O2 could increase action potential durations measured at the 50% repolarization levels and the 90% repolarization levels were prolonged(P<0.001),Reduced myocardial contractility(P<0.05) compared with before administation contraction force in guinea pigs compared with themselves before,Ranolazine can inhibit action potential durations measured at the 50% repolarization levels and the 90% repolarization levels were prolonged of H2O2,But the effect was weaker than TTX,Ranolazine and TTX could improve myocardial contractile force to reduce the H2O2-induced.Conclusion ranolazine could reduce action potential duration the H2O2-induced and increase contraction force.Similar to the role and TTX.",
        "keywords": [
            "arrhythmia",
            "contraction force",
            "the action potential",
            "ranolazine"
        ],
        "authors": [
            {
                "name": "WANG Guo-tao",
                "org": "China-Japan Union Hospital of Jilin University,Changchun ,China"
            },
            {
                "name": "ZHANG Wen-jie",
                "org": "Department of Physiology,Basic Medicine College,Jilin University"
            },
            {
                "name": "YANG Ping",
                "org": "China-Japan Union Hospital of Jilin University,Changchun ,China"
            }
        ],
        "venue": "Chinese Journal of Laboratory Diagnosis",
        "year": 2010
    },
    "cWPtRs2R": {
        "id": "cWPtRs2R",
        "title": "Study of relationship of atherosclerosis and vascular cell adhesion molecule-1 gene expression",
        "abstract": "Objective To investigate the relationship of atherosclerosis(AS) and vascular cell adhesion molecule-1(VCAM-1)gene expression.Methods Sixteen rabbits were randomly divided into control and cholesterol diet group,which were fed for 16 weeks in order to build the AS models,Serrm TC\u3001TG\u3001LDL were measured in 0,8 and 16 weeks in the two groups.The aortas were harvested for pathologic morphology observation.Immunohistochemistry analysis(S-P method\u3001DAB dye)and reverse transcription-polymerase chain reaction(RT-PCR)were performed to measure positive percentage and mRNA of VCAM-1 in aortas.Results There were not obviously difference among TC\u3001TG and LDL in the two groups in 0 week(P>0.05),but there were obviously increase of Tc and LDL in the high-cholestrol diet group than 8 weeks and 16 weeds(P<0.01)and obviously increase than control group(P<0.01).Atherosclerosis was formed in cholesterol group and the expressions of immunohistochemistry analysis and mRNA of VCAM-1 in cholesterol grop were higher than control(P<0.01),they were(18.38\u00b12.55)%and(2.92\u00b10.31)%\u30011.116\u00b10.017 and o.684\u00b10.006(P<0.01).Conclusion VCAM-1 can be excessively expressed in atherosclerosis,it may involve in the process of atherosclerosis.",
        "keywords": [
            "atherosclerosis",
            "vascular cell adhension molecule-1"
        ],
        "authors": [
            {
                "name": "QIN Ling",
                "org": "3,et al.(Department of Cardiology,The First Hospital,Jilin University,Changchun ,China)"
            },
            {
                "name": "YANG Ping",
                "org": "3,et al.(Department of Cardiology,The First Hospital,Jilin University,Changchun ,China)"
            },
            {
                "name": "ZHANG Jia-ying",
                "org": "3,et al.(Department of Cardiology,The First Hospital,Jilin University,Changchun ,China)"
            }
        ],
        "venue": "Chinese Journal of Laboratory Diagnosis",
        "year": 2006
    },
    "6rn9dBSE": {
        "id": "6rn9dBSE",
        "title": "Pulmonary hypertension with a huge thrombosis in main stem of pulmonary artery.",
        "abstract": "null",
        "keywords": [],
        "authors": [
            {
                "name": "P Yang",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "H Zeng",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "F Meng",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "L Zhao",
                "org": "Jilin University(Jilin University),Changchun,China"
            }
        ],
        "venue": "Chinese medical journal",
        "year": 2001
    },
    "zpZJYtW2": {
        "id": "zpZJYtW2",
        "title": "TGF-\u03b21 protein expression in scar tissue after myocardial infarction and its intervention by Qiliqiangxin capsule",
        "abstract": "Objective To investigate the effect of Qiliqiangxin capsule,a traditional Chinese medicine,on TGF-\u03b21 protein expression in myocardial infarction(MI) rats and explore its action mechanism of improving left ventricular remodeling.Methods 28 heart failure model rats made by left anterior descending coronary artery ligation and fed for 4 weeks were randomized into model,ramipril,Qiliqiangxin large and small dosage groups.4 weeks later,infarct zone TGF-\u03b21 mRNA expression was measured by RT-PCR,and plasma angiotensin \u2161(Ang\u2161) concentration was detected by ELISA.Results Compared with ramipril group,Qiliqiangxin large dosage group exerted more powerful effect on attenuation of plasma Ang \u2161(P<0.05),but there were no significant differences in TGF-\u03b21 mRNA expressions between these two groups(P>0.05).However,Qiliqiangxin small dosage group had less powerful effects on Ang II,had no difference from ramipril group(P>0.05).There was significant difference in TGF-\u03b21 protein level between Qiliqiangxin small and large dose groups(P<0.05).Conclusions The attenuation of TGF-\u03b21 by Qiliqiangxin capsule could reduce Ang II and TGF-\u03b21 in infarction zone in heart failure rats after MI and has dose dependency.",
        "keywords": [
            "Left ventricular remodeling",
            "Angiotensin II",
            "TGF-\u03b21",
            "Qiliqiangxin capsule"
        ],
        "authors": [
            {
                "name": "LI Jia-Yu",
                "org": ".Department of Cardiology,China-Japan Union Hospital of Jilin University,Changchun ,Jilin,China"
            },
            {
                "name": "YANG Ping",
                "org": ".Department of Cardiology,China-Japan Union Hospital of Jilin University,Changchun ,Jilin,China"
            }
        ],
        "venue": "Chinese Journal of Gerontology",
        "year": 2009
    },
    "KDGktqyK": {
        "id": "KDGktqyK",
        "title": "Characteristics of coronary angiography and related factors in female patients with chest pain",
        "abstract": "Objective To investigate the relationship between female patients with chest pain and coronary heart disease (CHD).Methods A total of 76 female patients with chest pain(40\uff5e60 ages) were examined by coronary angiography, who suffered from typical angina pectoris or atypical one which had ST-T ischemic changes on electrocardiogram (ECG).Their chest pain symptom,menopause age,the duration from appearing chest pain symptom to menopause,ST-T of ECG,spouse,lipid,blood glucose,history of hypertension and CAG result were analyzed.Results Coronary artery stenosis (CAS) group was 31.58%and coronary artery normal(CAN) group was 68.42%in 76 female patients.There was statistical difference of hypertension,no spouse,after menopause,typical heartstroke,no atypical angina pectoris symptom constituent ratio and the level of Lp(a) in CAN group and CAS group.Conclusions Femal patients with chest pain had high misdiagnosis rate of CHD by clinical symptom and ECG change.Doubtful CHD patients should screen by CAG or coronary arteriongraphy.",
        "keywords": [
            "female",
            "ST-T ischemic change",
            "hypertension",
            "coronary angiography",
            "lipid"
        ],
        "authors": [
            {
                "name": "WANG Guo-tao",
                "org": "China-Japan Union Hospital of Jilin University,Changchun,P.R.China"
            },
            {
                "name": "YANG Ping",
                "org": "China-Japan Union Hospital of Jilin University,Changchun,P.R.China"
            }
        ],
        "venue": "Shandong Medical Journal",
        "year": 2008
    },
    "2shy2JjQ": {
        "id": "2shy2JjQ",
        "title": "Effects of simvastatin on the number and adhesiveness of endothelial progenitor cells from umbilical vein blood cultured in vitro",
        "abstract": "Background: Statins can promote the angiogenesis following acute ischemia, accelerate the re-endothelialization of injured sacculus and reduce the hyperblastosis neointima. These effects are closely associated with vascular endothelial progenitor cells (EPCs). Objective: To isolate, purificate and culture EPCs from human umbilical vein blood, and to observe the effects on expansion and adhesion ability of the EPCs in different concentrations of simvastatin. Design, time and setting: Grouping control experiments were carried out in the Department of Pathophysiology, Basic Medical College of Jilin University from February to October in 2006. Materials: EPCs were selected from umbilical vein blood of the parturients underwent full-term normal delivery in the Department of Gynaecology and Obstetrics, the Second Hospital of Jilin University. Methods: EPCs were isolated by using density gradient centrifugation from human umbilical vein. Immunofluorescence assay was used to detect endothelial cell uptake and absorption acetylated low density lipoprotein and ulex europaeus agglutinin- I. EPCs quantitative detection of surface markers was performed by flow cytometry: CD133, CD34 antigen expression and KDR. Inverted microscope observation was used to assay the morphological changes of EPCs, cell count and the growth curve. Simvastatin concentration was ranked as 0, 0.01, 0.1, 1 and 10 \u03bc mol/L, while 0 \u03bc mol/L served as the controls. EPCs proliferation was observed by MTT method, adhesion of the EPCs was evaluated by counting the number of adherent cell. Main outcome measures: The morphological changes of vascular EPCs; the proliferation and adhesion of EPCs in different concentrations of simvastatin. Results: The cultured EPCs were shaped as long fusiform and became smaller at 2-4 days, as latent period; adherent cells increased at 6-10 days, as log proliferation period; cells showed a colony-like growth into cell fusion and the cells were significantly increased at 10-24 days, as growth platform period. Laser confocal microscopy revealed the differentiating EPCs could uptake acetylated low density lipoprotein and ulex europaeus agglutinin- I, which were stained as red and green fluorescence. Flow cytometry results showed the expression of CD133, CD34 and KDR antigen was (7.30\u00b12.71)%, (42.00\u00b16.42)% and (89.30\u00b110.45)%. MTT colorimetric results showed that the EPCs proliferation activity and number of adherent cells were all enhanced in the simvastatin groups compared with the controls (P < 0.05). However, the EPCs proliferation was the strongest in the concentration of 1 \u03bc moL/L. Conclusion: Simvastatin can increase the number and adhesion capacity of vascular EPCs cultured in vitro.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Song Xian-jing",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Bin Liu",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Ping Yang",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Feng Jiang",
                "org": "Chengde Medical College(Chengde Medical College,Hospital of Chengde Medical College),Chengde,China"
            }
        ],
        "venue": "Journal of Clinical Rehabilitative Tissue Engineering Research",
        "year": 2008
    },
    "RGWtaHsZ": {
        "id": "RGWtaHsZ",
        "title": "Effects of Trimetazidine on Autonomic Nervous Function of Aged Patients with Chronic Heart Failure",
        "abstract": "Objective To investigate the effects of trimetazidine on the autonomic nervous function in elderly patients with chronic heart failure.Methods 35 elderly patients with heart failure were randomly divided into control group and trimetazidine group.All patients were treated with conventional drug therapy,while trimetazidine group was treated with additional 20 mg trimetazidine three times/day orally.Echocardiography and 24-hour heart rate variability were tested before treatment and 12 weeks after the treatment.Results Ejection fraction of the patients in the trimetazidine group was more significantly increased(P<0.05) than the control group(P<0.05).The HRV parameters were significantly increased after treatment in the two groups(P<0.05),and the trimetazidine group was increased more significantly(P<0.05).Conclusion Adding trimetazidine to optimal medical therapy in aged patients with heart failure may improve the autonomic nervous function and increase HRV parameters without any side effects.",
        "keywords": [
            "Heart failure",
            "Trimetazidine",
            "Heart rate variability"
        ],
        "authors": [
            {
                "name": "MA Pi-yong",
                "org": ".Emergency Department of China-Japan Union Hospital,Jilin University,Changchun ,China"
            },
            {
                "name": "SUN Xiao-li",
                "org": ".Emergency Department of China-Japan Union Hospital,Jilin University,Changchun ,China"
            },
            {
                "name": "YANG Ping",
                "org": ".Emergency Department of China-Japan Union Hospital,Jilin University,Changchun ,China"
            }
        ],
        "venue": "Chinese General Practice",
        "year": 2011
    },
    "MQvAjSs8": {
        "id": "MQvAjSs8",
        "title": "Rapamycin regulates the balance between\u00a0cardiomyocyte apoptosis and autophagy in chronic heart failure by inhibiting mTOR signaling.",
        "abstract": "The progressive loss of cardiomyocytes caused by cell death leads to cardiac dysfunction and heart failure (HF). Rapamycin has been shown to be cardioprotective in pressure\u2011overloaded and ischemic heart diseases by regulating the mechanistic target of rapamycin (mTOR) signaling network. However, the impact of rapamycin on cardiomyocyte death in chronic HF remains undetermined. Therefore, in the current study we addressed this issue using a rat myocardial infarction (MI)\u2011induced chronic HF model induced by ligating the coronary artery. Following surgery, rats were randomly divided into six groups, including the sham\u2011, vehicle\u2011 and rapamycin\u2011operated groups, at 8 or 12\u00a0weeks post\u2011MI. A period of 4 weeks after MI induction, the rats were treated with rapamycin (1.4\u00a0mg\u2011kg\u2011day) or vehicle for 4 weeks. Cardiac function was determined using echocardiography, the rats were subsequently euthanized and myocardial tissues were harvested for histological and biochemical analyses. In the cell culture experiments with H9c2 rat cardiomyocytes, apoptosis was induced using angiotensin II (100\u00a0nM; 24\u00a0h). Cardiomyocyte apoptosis and autophagy were assessed via measuring apoptosis\u2011 and autophagy\u2011associated proteins. The activities of mTOR complex 1 (mTORC1) and mTORC2 were evaluated using the phosphorylation states of ribosomal S6 protein and Akt, respectively. The activity of the endoplasmic reticulum (ER) stress pathway was determined using the levels of GRP78, caspase\u201112, phospho\u2011JNK and DDIT3. Echocardiographic and histological measurements indicated that rapamycin treatment improved cardiac function and inhibited cardiac remodeling at 8\u00a0weeks post\u2011MI. Additionally, rapamycin prevented cardiomyocyte apoptosis and promoted autophagy at 8 weeks post\u2011MI. Rapamycin treatment for 4\u00a0weeks inhibited the mTOR and ER stress pathways. Furthermore, rapamycin prevented angiotensin\u00a0II\u2011induced H9c2 cell apoptosis and promoted autophagy by inhibiting the mTORC1 and ER stress pathways. These results demonstrated that rapamycin reduced cardiomyocyte apoptosis and promoted cardiomyocyte autophagy, by regulating the crosstalk between the mTOR and ER stress pathways in chronic HF.",
        "keywords": "",
        "authors": [
            {
                "name": "Guangyuan Gao",
                "org": "Department of Cardiology, China\u2011Japan Union Hospital of Jilin University, Changchun, Jilin 130031, P.R. China."
            },
            {
                "name": "Weiwei Chen",
                "org": "Department of Cardiology, China\u2011Japan Union Hospital of Jilin University, Changchun, Jilin 130031, P.R. China."
            },
            {
                "name": "Mengjie Yan",
                "org": "Department of Cardiology, China\u2011Japan Union Hospital of Jilin University, Changchun, Jilin 130031, P.R. China."
            },
            {
                "name": "Jinsha Liu",
                "org": "Department of Cardiology, China\u2011Japan Union Hospital of Jilin University, Changchun, Jilin 130031, P.R. China."
            },
            {
                "name": "Huiling Luo",
                "org": "Department of Cardiology, China\u2011Japan Union Hospital of Jilin University, Changchun, Jilin 130031, P.R. China."
            },
            {
                "name": "Chang Wang",
                "org": "Department of Cardiology, China\u2011Japan Union Hospital of Jilin University, Changchun, Jilin 130031, P.R. China."
            },
            {
                "name": "Ping Yang",
                "org": "Department of Cardiology, China\u2011Japan Union Hospital of Jilin University, Changchun, Jilin 130031, P.R. China."
            }
        ],
        "venue": "International journal of molecular medicine",
        "year": 2019
    },
    "Y1qwyh3C": {
        "id": "Y1qwyh3C",
        "title": "Effect of immunoglobulin on heart function and collagen in noninfarction zone in heart failure rats",
        "abstract": "Objective To investigate the effects of immunoglobulin on heart function and collagen in noninfarction zone(NIZ) in heart failure rats after myocardial infarction(MI).Methods The rat model of heart failure was established by left anterior descending coronary artery deligation.After 6 w,24 surviving rats were divided into sham,model and immunoglobulin groups at random,8 rats in each,and were treated with medicines by intraperitoneal injectionrespectively.At 10 w,left ventricular end-diastolic pressure(LVEDP),left ventricular systolic pressure(LVSP),+ dp/ dtmax and-dp/ dtmax of left ventricular pressure were measured.Results Immunoglobulin increased significantly LVSP and + dp/dtmax,-dp/ dtmax of left ventricular pressure and decreased significantly LVEDP.But there was no influence on HR,SBP and DBP(P>0.05).Conclusions Immunoglobulin could inhibit myocardial interstitial collagen reconstitution on heart failure after AMI in rats,which may be related to lightening collagen deposition in NIZ in the development heart failure.",
        "keywords": [
            "Heart failure",
            "Immunoglobulin",
            "Collagen",
            "Heart function"
        ],
        "authors": [
            {
                "name": "YANG Jie",
                "org": ".Department of Endocrine,China-Japan Union Hospital,Jilin University,Changchun ,Jilin,China"
            },
            {
                "name": "YANG Ping",
                "org": ".Department of Endocrine,China-Japan Union Hospital,Jilin University,Changchun ,Jilin,China"
            },
            {
                "name": "HUAI Shu-Jun",
                "org": ".Department of Endocrine,China-Japan Union Hospital,Jilin University,Changchun ,Jilin,China"
            }
        ],
        "venue": "Chinese Journal of Gerontology",
        "year": 2011
    },
    "quNi3kWC": {
        "id": "quNi3kWC",
        "title": "Changes of expressions of CD61p, CD62p and plasma vWF concentration in patients with acute coronary syndrome and drug intervention",
        "abstract": "Objective: To study the effects of Ozagre on CD62p, CD61, which was used as platelet marks and von willebran actor (vWF) in patients with acute coronary syndrome (ACS), and meanwhile to study the relationships between CD62p, CD61 and vWF. Methods: CD62p, CD61 from whole-blood samples were measured by FCM and vWF was measured by ELISA method in 36 patients with ACS and 20 normal peoples used as control group. Results: The amount of expression of CD62p was (89.60 \u00b1 6.98)% in ACS patients group and (40.88 \u00b1 7.56)% in control group, there was obvious difference between ACS group and control group (P<0.05). The amount of CD62p was decreased to (66.11 \u00b1 8.72)% after treated with 04agre (P<0.05). There was also significant difference of CD62p in ACS group between before and after intervention of ozagre (P<0.05). The amount change of CD62p in patients with ACS was agreement with the improvement of angina pectoris and the changes in sum of ST segements. However there was no difference of CD61 between ACS group and control group (P>0.05). There was also no difference of CD61 between before and after treatment of Ozagre (P>0.05). Conclusion: CD62p is a sensitive index of platelet activation in ACS patients and there is excellent relationship between CD62p and vWF and clinical symptoms.",
        "keywords": [
            "Acute disease",
            "Flow cytometry",
            "Platelet membrane glycoproteins",
            "Syndrome",
            "von Willebran factor"
        ],
        "authors": [
            {
                "name": "ZHOU Xue-yan",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Ping Yang",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "ZHENG De-ming",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Zhi Hong Yuan",
                "org": "Changchun Institute of Biological Products(Changchun Institute of Biological Products),Changchun,China"
            },
            {
                "name": "ZHOU Chuan-kai",
                "org": "Changchun Institute of Biological Products(Changchun Institute of Biological Products),Changchun,China"
            },
            {
                "name": "Jun Guo",
                "org": "Jilin University(Jilin University),Changchun,China"
            }
        ],
        "venue": "Journal of Jilin University(Medicine Edition)",
        "year": 2006
    },
    "0DiwtMrh": {
        "id": "0DiwtMrh",
        "title": "Evaluation of VZV-specific Cell-mediated Immunity by Interferon-gamma ELISA in Adults \u226550 Years of Age Administered a Herpes Zoster Vaccine.",
        "abstract": "Varicella-zoster virus (VZV)-specific cell-mediated immunity (CMI) is critical for preventing and controlling the onset of herpes zoster (HZ). To assess VZV CMI, an interferon-gamma (IFN-\u03b3) enzyme-linked immunosorbent assay (ELISA) was validated by examining the influence of VZV-specific antigen content, incubation time, and interval from whole blood collection on the assay. In the phase II clinical trial, VZV-specific CMI in adults \u226550 years of age administered an HZ vaccine were evaluated by IFN-\u03b3 ELISA, as determined by measuring IFN-\u03b3 production in the whole blood in response to stimulation with ultraviolet light-inactivated VZV. The VZV-specific IFN-\u03b3 levels varied among individuals from pre-vaccination (baseline) to 6 weeks post-vaccination. In most subjects, VZV-specific CMI was increased at 6 weeks post-vaccination. The HZ vaccine elicited a significant increase in the VZV-specific CMI response as measured by ELISA; the geometric mean fold-rises (GMFRs) from baseline to 6 weeks post-vaccination were 3.50, 4.22, and 5.24 in the 4.3, 4.7, and 4.9 log PFU vaccine groups, respectively, which was significantly higher than in the placebo group (P<0.05). These results indicate that vaccination enhances the VZV-specific CMI responses in subjects; IFN-\u03b3 ELISA is an effective method for evaluating the CMI response and may be useful for identifying individuals at a high risk of HZ infection. This article is protected by copyright. All rights reserved.",
        "keywords": [
            "Interferon-gamma enzyme-linked immunosorbent assay",
            "cell-mediated immunity",
            "herpes zoster vaccine",
            "varicella-zoster virus"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, China."
            },
            {
                "name": "Zhen Chen",
                "org": "National Institutes for Food and Drug Control, Beijing, China."
            },
            {
                "name": "Jieqiong Zhang",
                "org": "Changchun BCHT Biotechnology Company, Changchun, China."
            },
            {
                "name": "Wei Li",
                "org": "Changchun BCHT Biotechnology Company, Changchun, China."
            },
            {
                "name": "Changlin Zhu",
                "org": "Changchun BCHT Biotechnology Company, Changchun, China."
            },
            {
                "name": "Ping Qiu",
                "org": "National Institutes for Food and Drug Control, Beijing, China."
            },
            {
                "name": "Yaru Quan",
                "org": "National Institutes for Food and Drug Control, Beijing, China."
            },
            {
                "name": "Xiaoyu Cui",
                "org": "National Institutes for Food and Drug Control, Beijing, China."
            },
            {
                "name": "Liyong Yuan",
                "org": "National Institutes for Food and Drug Control, Beijing, China."
            },
            {
                "name": "Chunlai Jiang",
                "org": "Key Laboratory for Molecular Enzymology & Engineering, Ministry of Education, Jilin University, Changchun, China."
            }
        ],
        "venue": "Journal of medical virology",
        "year": 2019
    },
    "DMJ5mz2r": {
        "id": "DMJ5mz2r",
        "title": "GW29-e1601 Ghrelin partially protects against heart failure after myocardial infarction by increasing the Bcl-2/Bax ratio in a GHS-R1a-dependent manner",
        "abstract": "Increasing evidence suggested the cardioprotective effects of ghrelin in heart failure (HF) after myocardial infarction (MI). However, the underlying mechanism of its protective effects against post-MI HF remains unclear. Here, we aimed to study whether ghrelin can directly protect myocardial from",
        "keywords": "",
        "authors": [
            {
                "name": "Chunyan Yang",
                "org": "Department of Cardiology"
            },
            {
                "name": "Chunyan Yang",
                "org": "Department of Cardiology"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Cardiology"
            },
            {
                "name": "Ping Yang",
                "org": "Department of Cardiology"
            }
        ],
        "venue": "Journal of the American College of Cardiology",
        "year": 2018
    },
    "fez4b1gM": {
        "id": "fez4b1gM",
        "title": "Insulin Resistance and the Function of Pancreatic \u03b2-cell in Patients With Prior Coronary Heart Disease and Normal Fasting Plasm Glucose",
        "abstract": "Objective:To explore the prevalence of abnormal glucose regulation,the function of pancreatic \u03b2-cell and insulin resistance(IR)in patients with coronary heart disease(CHD)and normal fasting plasm glucose(FPG).Methods:Seventy five gram oral glucose tolerance testing(OGTT)was performed in 35 patients with CHD and 30 normal controls.Plasma glucose and insulin after OGTT were measured at 0,30,60,120 and 180 minutes and body height/weight,blood pressure,blood lipids(TC,TG)were measured.Insulin secretion and insulin resistance were evaluated.The early insulin secretion index(\u25b3I30/\u25b3G30,HOMA-IR = FINS\u00d7FPG/22.5),HOMA-\u03b2 cell index(HBCI=20\u00d7FINS/(FPG-3.5));and Li's new \u03b2 cell insulin secretion index(MBCI=(FINS\u00d7FPG)/(PG2h+PG1h-2FPG))were calculated.Results:In patients with CHD and normal FPG,43% had abnormal glucose regulation(2-h postload blood glucose\u22657.8 mmol/L)higher than those of controls(23%).By FPG,abnormal glucose in these patients were not found.Insulin at 0,120,180 minutes and HOMA-IR in patients with CHD was higher than that of controls(11.4\u00b19.4 vs 5.3\u00b13.1 mU/L,71.6\u00b148.5 vs 31.2\u00b122.0 mU/L,42.7\u00b135.4 vs 8.6\u00b16.9 mU/L,0.63\u00b10.32 vs 0.47\u00b10.21;P<0.01).\u25b3I30/\u25b3G30,MBCI were lower than those of controls(1.13\u00b10.65 vs 1.42\u00b10.57,1.03\u00b10.35 vs 1.36\u00b10.37;P<0.01).Logistic regression analysis revealed that insulin at 120 minutes,HOMA-IR and TC were positively correlated with the development of CHD(OR 1.432,0.644 and 1.116,respectively,P<0.05).Conclusions:Abnormal glucose in patients with CHD and normal FPG is higher than that of controls.OGTT is a feasible tool to disclose glucometabolic status and it should be included in the diagnostic routine examinations of such patients.There exist IR and dysfunction of pancreatic \u03b2-cell in patients with CHD.",
        "keywords": [
            "Pancreatic \u03b2-cell",
            "Impaired glucose regulation",
            "Insulin resistance",
            "Coronary heart disease"
        ],
        "authors": [
            {
                "name": "SUN Wei-xia",
                "org": ".Department of Cardiology,China-Japan Union Hospital of Jilin University,Changchun%%#%%#,Jilin,China"
            },
            {
                "name": "YANG Ping",
                "org": ".Department of Cardiology,China-Japan Union Hospital of Jilin University,Changchun%%#%%#,Jilin,China"
            },
            {
                "name": "ZHOU Xue-yan",
                "org": ".Department of Cardiology,China-Japan Union Hospital of Jilin University,Changchun%%#%%#,Jilin,China"
            }
        ],
        "venue": "Chinese Circulation Journal",
        "year": 2007
    },
    "Lt9GLTnw": {
        "id": "Lt9GLTnw",
        "title": "(3R)\u20115,6,7\u2011trihydroxy\u20113\u2011isopropyl\u20113\u2011methylisochroman\u20111\u2011one attenuates cardiac dysfunction via the apelin/APJ signaling pathway.",
        "abstract": "Myocardial infarction (MI) is associated with a high risk of mortality and is a major global health concern. The present study aimed to investigate the protective effects of (3R)\u20115,6,7\u2011trihydroxy\u20113\u2011isopropyl\u20113\u2011methylisochroman\u20111\u2011one (TIM) against MI induced by isoproterenol (ISO) in a rat model and the underlying mechanisms. Wistar rats were assigned to 4 groups (n=10): The control group received saline treatment; the ISO group received an intraperitoneal injection of ISO (100\u00a0mg/kg); and the TIM (low) and TIM (high) groups received an intraperitoneal injection of ISO, plus a 1 and 2\u00a0mg/kg dose of TIM orally, respectively. TIM rats were treated with TIM daily for 12\u00a0days and received ISO injections on the final 2\u00a0days to induce MI. Cardiac function, apoptosis index and protein expression were subsequently determined. The levels of oxidative stress markers were determined by ELISAs, whereas DNA damage was detected using a Cell Death Detection ELISA kit. Gene and protein expression were determined via reverse transcription\u2011quantitative polymerase chain reaction and western blot analyses, respectively. Following treatment with ISO, the maximum left ventricular contraction/relaxation velocity and left ventricular systolic pressure were significantly decreased, whereas the left ventricular end\u2011diastolic pressure was increased; however, treatment with TIM significantly ameliorated ISO\u2011induced cardiac dysfunction. Additionally, TIM treatment significantly decreased oxidative stress and inhibited the apoptosis of cardiomyocytes, as determined by a decrease in caspase activities, increased expression of B\u2011cell lymphoma\u00a02 (Bcl\u20112) and reduced expression of cleaved caspase\u20113, cleaved caspase\u20119 and Bcl\u20112\u2011associated X. Furthermore, treatment with TIM upregulated the levels of apelin in the plasma and myocardium of ISO\u2011treated rats. The results indicated that TIM protected cardiomyocytes against ISO\u2011induced MI, potentially via the apelin/apelin receptor signaling pathway. The results of the present study suggested that TIM may be a potential novel therapy for the treatment of MI.",
        "keywords": "",
        "authors": [
            {
                "name": "Mei Ding",
                "org": "Department of Cardiology, China\u2011Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China."
            },
            {
                "name": "Lianyue Guan",
                "org": "Department of Hepatobiliary\u2011Pancreatic Surgery, China\u2011Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China."
            },
            {
                "name": "Chunmei Zhang",
                "org": "Department of Emergency, China\u2011Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China."
            },
            {
                "name": "Ping Yang",
                "org": "Department of Cardiology, China\u2011Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China."
            },
            {
                "name": "Hailing Yang",
                "org": "Department of Emergency, China\u2011Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China."
            }
        ],
        "venue": "Molecular medicine reports",
        "year": 2019
    },
    "8FDwTUw1": {
        "id": "8FDwTUw1",
        "title": "Ranolazine's Protective Effect on Ischemic Myocardium",
        "abstract": "Ranolazine is a new cardiovascular drug whose mechanism is related to the inhibition of late Na+ current in cardiac myocytes.Ranolazine reduces late sodium,thus decreasing sodium entry into ischemic myocardial cells,and subsequently improves myocardial ischemia,cardiac diastolic function and tends to prevent related cardiac arrhythmias.Clinical studies have shown that ranolazine could increase exercise tolerance,decrease anginal attacks,and nitroglycerin consumption.Ranolazine also has anti-arrhythmic effects and may improve cardiac systolic and diastolic function.",
        "keywords": [
            "late sodium current",
            "ischaemic heart disease",
            "ranolazine"
        ],
        "authors": [
            {
                "name": "WANG Guo-tao",
                "org": "Department of Cardiology,The Fourth Hospital of Daqing,Daqing ,Heilongjiang,China"
            },
            {
                "name": "YANG Ping",
                "org": "China-Japan Union Hospital of Jilin University,Changchun ,Jilin,China"
            }
        ],
        "venue": "Advances in Cardiovascular Diseases",
        "year": 2011
    },
    "oZXyr4LD": {
        "id": "oZXyr4LD",
        "title": "Primary pulmonary artery rhabdomyosarcoma.",
        "abstract": "A 69-year-old woman presented with a 4-month history of dyspnoea and radiating upper-right quadrant pain and oedema in her lower extremities for more than 20 days. The ultrasonographic study of the heart revealed the adherence of a substantive hypoechoic mass (73 x 34 mm) to the antelateral wall of the pulmonary artery and resultant pulmonary stenosis. Computed tomographic imaging of the pulmonary artery revealed an irregularly shaped filling defect (approximately 41 x 39 x 59 mm) in the main pulmonary artery. The boundary of the defect was irregular, but demarcation with healthy tissue was clear. After surgical treatment, the histologic and immunohistochemical assays revealed a primary pulmonary artery rhabdomyosarcoma. Pulmonary artery rhabdomyosarcomas are usually misdiagnosed as other pulmonary artery obstructive diseases. There should be a greater focus of clinical attention and resection is the appropriate surgical treatment for such malignant tumours.",
        "keywords": [
            "embolism",
            "pulmonary artery",
            "rhabdomyosarcoma",
            "sarcoma"
        ],
        "authors": [
            {
                "name": "Daoyuan Si",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Bomin Zhang",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Xiuhe Zhang",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Mingqiu Zhang",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Lujia Ni",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Ping Yang",
                "org": "Jilin University(Jilin University),Changchun,China"
            }
        ],
        "venue": "Acta cardiologica",
        "year": 2011
    },
    "nTNepWF5": {
        "id": "nTNepWF5",
        "title": "Unique Ventricular Tachycardia Originating from the Right Bundle Branch.",
        "abstract": "Ventricular tachycardia (VT), a common arrhythmia, frequently originates from in the right ventricular outflow tract, left ventricular outflow tract, aortic sinus, and left ventricular papillary muscle but infrequently from the His-Purkinje system, whereas the VT stemming from the right bundle branch has rarely been reported. Here we reported a case with of VT originating from the right bundle branch which was subsequently successfully treated with radiofrequency ablation and demonstrated the electrocardiac features of VT using an electrophysiological examination.",
        "keywords": [
            "Catheter ablation",
            "Electrophysiology",
            "Ventricular tachycardia"
        ],
        "authors": [
            {
                "name": "Hongliang Yang",
                "org": "Department of Cardiology, China-Japan Union Hospital of Jilin University, Chang Chun, Jilin, China."
            },
            {
                "name": "Daoyuan Si",
                "org": "Department of Cardiology, China-Japan Union Hospital of Jilin University, Chang Chun, Jilin, China."
            },
            {
                "name": "Yaliang Tong",
                "org": "Department of Cardiology, China-Japan Union Hospital of Jilin University, Chang Chun, Jilin, China."
            },
            {
                "name": "Zhe An",
                "org": "Department of Cardiology, China-Japan Union Hospital of Jilin University, Chang Chun, Jilin, China."
            },
            {
                "name": "Ping Yang",
                "org": "Department of Cardiology, China-Japan Union Hospital of Jilin University, Chang Chun, Jilin, China."
            },
            {
                "name": "Yuquan He",
                "org": "Department of Cardiology, China-Japan Union Hospital of Jilin University, Chang Chun, Jilin, China."
            }
        ],
        "venue": "Acta Cardiologica Sinica",
        "year": 2017
    },
    "H782GlEg": {
        "id": "H782GlEg",
        "title": "GW29-e0587 Comparative Analysis of Bind Energies and Sites between Simvastatin and Atorvastatin into CYP3A4",
        "abstract": "To study the relationship between the discrepancy of CYP3A4-mediated drug interactions of statins in clinical trials and different bind energy of simvastatin and atorvastatin to CYP3A enzymes.Molecular docking and molecular dynamics simulations were performed to investigate the three-dimensional",
        "keywords": "",
        "authors": [
            {
                "name": "Tiechao Jiang",
                "org": "Cardiac Department of China-Japan Union Hospital of Jilin University"
            },
            {
                "name": "Guangwei Sun",
                "org": "Jilin Provincial Academy of Chinese Medicine"
            },
            {
                "name": "Tianzhu He",
                "org": "Changchun University of Chinese Medicine"
            },
            {
                "name": "Ping Yang",
                "org": "Cardiac Department of China-Japan Union Hospital of Jilin University"
            }
        ],
        "venue": "Journal of the American College of Cardiology",
        "year": 2018
    },
    "OdNbdrSk": {
        "id": "OdNbdrSk",
        "title": "Value of Ankle-Brachial Index in Predicting the Extent of Coronary Atherosclerosis and Cardiovascular Events in Patients with Coronary Artery Disease",
        "abstract": "Coronary heart disease(CHD) is one of the major diseases that threaten the health of humans today.Early diagnosis and prediction of the risk of CHD is very important for the treatment of CHD.Compared with conventional risk factors,ankle-brachial Index is a simple,inexpensive,and non-invasive measurement with high specificity and sensitivity for diagnosis and the prediction of the risk of CHD,with conspicuous dependability on the degree of narrowness in the coronary artery.",
        "keywords": [
            "coronary heart disease",
            "ankle-brachial index"
        ],
        "authors": [
            {
                "name": "WU Yuan",
                "org": "China-Japan Union Hospital of Jilin University,Changchun ,China"
            },
            {
                "name": "YANG Ping",
                "org": "China-Japan Union Hospital of Jilin University,Changchun ,China"
            }
        ],
        "venue": "Advances in Cardiovascular Diseases",
        "year": 2008
    },
    "mAeFtoGk": {
        "id": "mAeFtoGk",
        "title": "Effect of estrogen replacement therapy in the early phase on atherosclerosis in rats",
        "abstract": "Objective:To understand the effect of estrogen replacement therapy(ERT) in the early phase on atherosclerosis in rats fed by high fat diet.Methods:28 rats were divided into 4 groups:group A(sham operation),group B(ovariectomized without estradiol),group C(ovariectomized with low-dose estradiol) and group D(ovariectomized with high-dose estradiol).All the rat in 4 groups were given 1% cholesterol diet for 12 weeks,the levels of blood lipids,estradiol and serum superoxide dismutase(SOD) activity were detected before the operation and on the fourth and twelfth weeks.Results:After 12 weeks,the level of estradiol in group B was significantly lower than that in group A(P<0.05),the level of estradiol in group D was significantly higher than that in group A(P<0.05),there was no difference in the level of estradiol between group C and group A(P>0.05);the levels of TC and LDL-C in group B were significantly higher than those in group A(P<0.05);the levels of TC and LDL-C in group C and group D were significantly lower than those in group A(P<0.05),and levels of TC and LDL-C in group B were the lowest among four groups.The aortic plaque area in group B was the largest among four groups(P<0.05),the aortic plaque areas in group C and group D were smaller than that in group A(P<0.05).The serum SOD activity of group B decreased significantly.Conclusion:Estrogen replacement therapy in the early phase can improve the metabolism of the serum lipids,increase the SOD activity and inhibit the formation of atherosclerosis.",
        "keywords": [
            "Atherosclerosis",
            "Estrogen replacement therapy",
            "Superoxide dismutase",
            "Ovariectomized rats",
            "Blood lipids"
        ],
        "authors": [
            {
                "name": "WANG Guo-Tao",
                "org": ".Department of Cardiology,China-Japan Union Hospital of Jilin University,Changchun ,Jilin,China"
            },
            {
                "name": "YANG Ping",
                "org": ".Department of Cardiology,China-Japan Union Hospital of Jilin University,Changchun ,Jilin,China"
            }
        ],
        "venue": "Maternal and Child Health Care of China",
        "year": 2009
    },
    "DrYrtOW0": {
        "id": "DrYrtOW0",
        "title": "The effects of amlodipine and S(-)-amlodipine on vascular endothelial function in patients with hypertension.",
        "abstract": "Amlodipine has been shown to improve vascular endothelial function in hypertensive patients, but whether S(-)-amlodipine has a similar effect remains controversial. This study compared the effects of amlodipine and S(-)-amlodipine on vascular endothelial function in hypertensive patients and investigated relevant mechanisms of action in cell culture.Twenty-four patients with essential hypertension received amlodipine and S(-)-amlodipine for 6 weeks in a randomized, crossover study. Associated flow-mediated dilation (FMD), nitric oxide (NO), and endothelial nitric oxide synthase (eNOS) levels were determined. NO levels were measured after exposure of human umbilical vein endothelial cells (HUVECs) to amlodipine, S(-)-amlodipine, the eNOS inhibitor N w-nitro-L-arginine (L-NA), and the Protein Kinase C (PKC) inhibitor Ro 31-8220. Phosphorylation levels of Ser(1177) and Thr(495) in eNOS were determined after exposure to amlodipine, S(-)-amlodipine, and Ro 31-8220.FMD, NO, and eNOS levels significantly improved after treatment with amlodipine and S(-)-amlodipine. The levels were all higher with amlodipine, although the between-treatment difference was not statistically significant. Amlodipine and S(-)-amlodipine significantly increased NO levels in cultured HUVECs, but increases in NO levels were more marked with amlodipine. Western blot assay showed that both amlodipine and Ro31-8220 induced Ser(1177) phosphorylation and weakened Thr(495) phosphorylation in eNOS. S(-)-amlodipine had no similar effects. Amlodipine, but not S(-)-amlodipine, decreased the PKC phosphorylation in a time-dependent manner.Amlodipine and S(-)-amlodipine can both improve endothelial function in hypertensive patients. Amlodipine has greater potential for vascular endothelial protection than S(-)-amlodipine. It affects eNOS phosphorylation at Ser(1177) and Thr(495) by the PKC pathway, further enhancing eNOS activation.",
        "keywords": [
            "doppler ultrasonography",
            "s(-)-amlodipine.",
            "amlodipine",
            "blood pressure",
            "endothelial function",
            "hypertension",
            "phosphorylation"
        ],
        "authors": [
            {
                "name": "Yuquan He",
                "org": "Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, China."
            },
            {
                "name": "Daoyuan Si",
                "org": ""
            },
            {
                "name": "Chunyan Yang",
                "org": ""
            },
            {
                "name": "Lujia Ni",
                "org": ""
            },
            {
                "name": "Bing Li",
                "org": ""
            },
            {
                "name": "Mei Ding",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            }
        ],
        "venue": "American journal of hypertension",
        "year": 2014
    },
    "OXXoOg4f": {
        "id": "OXXoOg4f",
        "title": "Imaging of Pericardiophrenic Bundles Using Multislice Spiral Computed Tomography for Phrenic Nerve Anatomy.",
        "abstract": "Phrenic nerve injury and diaphragmatic stimulation are common complications following arrhythmia ablation and pacing therapies. Preoperative comprehension of phrenic nerve anatomy via non-invasive CT imaging may help to minimize the electrophysiological procedure-related complications.Coronary CT angiography data of 121 consecutive patients were collected. Imaging of left and right pericardiophrenic bundles was performed with volume rendering and multi-planar reformation techniques. The shortest spatial distances between phrenic nerves and key electrophysiology-related structures were determined. The frequency of the shortest distances \u22645 mm, >5 mm and direct contact between phrenic nerves and adjacent structures were calculated.Left and right pericardiophrenic bundles were identified in 86.8% and 51.2% of the patients, respectively. The right phrenic nerve was <5 mm from right superior and inferior pulmonary veins in 92.0% and 3.2% of the patients, respectively. The percentage of right phrenic nerve, <5 mm from right atrium, superior caval vein, and superior caval vein-right atrium junction was 87.1%, 100% and 62.9%, respectively. Left phrenic nerve was <5 mm from left atrial appendage, great cardiac vein, anterior and posterior interventricular veins, and left ventricular posterior veins in 81.9%, 1.0%, 39.1%, 28.6% and 91.4% of the patients, respectively. Merely 0.06% left phrenic nerve had a distance <5 mm with left superior pulmonary vein, and none left phrenic nerve showed a distance <5 mm with left inferior pulmonary vein.One-stop enhanced CT scanning enabled detection of phrenic nerve anatomy, which might facilitate avoidance of the phrenic nerve related complications in interventional electrophysiology. This article is protected by copyright. All rights reserved.",
        "keywords": [
            "X-ray computer",
            "anatomy",
            "cardiac electrophysiology",
            "phrenic nerve",
            "tomography"
        ],
        "authors": [
            {
                "name": "Yan-Jing Wang",
                "org": "Division of Cardiology, China-Japan Union Hospital of Jilin University, Jilin Provincial Cardiovascular Institute, 126 Xiantai Street, Changchun, Jilin, China, 130033."
            },
            {
                "name": "Lin Liu",
                "org": "Division of Cardiology, China-Japan Union Hospital of Jilin University, Jilin Provincial Cardiovascular Institute, 126 Xiantai Street, Changchun, Jilin, China, 130033."
            },
            {
                "name": "Meng-Chao Zhang",
                "org": "Division of Cardiology, China-Japan Union Hospital of Jilin University, Jilin Provincial Cardiovascular Institute, 126 Xiantai Street, Changchun, Jilin, China, 130033."
            },
            {
                "name": "Huan Sun",
                "org": "Division of Cardiology, China-Japan Union Hospital of Jilin University, Jilin Provincial Cardiovascular Institute, 126 Xiantai Street, Changchun, Jilin, China, 130033."
            },
            {
                "name": "Hong Zeng",
                "org": "Division of Cardiology, China-Japan Union Hospital of Jilin University, Jilin Provincial Cardiovascular Institute, 126 Xiantai Street, Changchun, Jilin, China, 130033."
            },
            {
                "name": "Ping Yang",
                "org": "Division of Cardiology, China-Japan Union Hospital of Jilin University, Jilin Provincial Cardiovascular Institute, 126 Xiantai Street, Changchun, Jilin, China, 130033."
            }
        ],
        "venue": "Journal of cardiovascular electrophysiology",
        "year": 2016
    },
    "L5DaBBrd": {
        "id": "L5DaBBrd",
        "title": "Association study of CD36 single nucleotide polymorphisms with essential hypertension in the Northeastern Han Chinese",
        "abstract": "We found that cluster determinant 36 (CD36) gene is up-regulated in essential hypertension (EH) patients in our former research, but the association between CD36 gene variations and EH has not yet been clearly demonstrated. The relationship between CD36 gene single nucleotide polymorphisms (SNPs) and EH in the northeastern Han Chinese was examined in the present study through direct sequencing and genotype-detection. A total of 589 unrelated northeastern Han Chinese including 276 with EH and 313 controls were studied. SNPs in exon 7, exon 13 and intron 4 were detected using PCR-sequencing. The genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) or polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP). +216T/C, +273A/G, +132C/T, +217T/C, +212T/G and +233T/C polymorphisms were identified. Distributions of genotypes AA, GA and GG of +273A/G polymorphism were significantly different between EH group and the control group (\u03c72: 9.056, p=0.011) and G allelic frequency was higher in EH (p=0.006, OR=1.629, 95% CI [1.224-2.168]). Logistic regression analysis showed that +273A/G polymorphism was closely associated with blood pressure (BP) after adjusting for ages. When subclassified by sex, the genotype distribution of +273A/G (p=0.011) and allelic frequency of G allele (p=0.006) were significantly different between EH participants and controls in males, but not in females. Subgroup analysis performed by body mass index (BMI) suggested that the genotype distribution of +273A/G and allelic frequency were significantly different in non-obese group and non-obese men, but the associations were not significant (non-obese group: p=0.016, OR=1.664, 95% CI [1.459-2.409]; non-obese men: p=0.073, OR=1.898, 95% CI [1.033-3.487]). +273A/G polymorphism in CD36 gene was associated with EH, and +273G could be an independent predictor. \u00a9 2013 Elsevier B.V.",
        "keywords": [
            "CD36",
            "Comparative study",
            "Essential hypertension",
            "Genetics",
            "Molecular marker",
            "Single nucleotide polymorphism"
        ],
        "authors": [
            {
                "name": "",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Fanbo Meng",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Ping Yang",
                "org": "Jilin University(Jilin University),Changchun,China"
            }
        ],
        "venue": "Gene",
        "year": 2013
    },
    "7WYLsPK4": {
        "id": "7WYLsPK4",
        "title": "Expression of NF-\u03baB in rats with myocardial ischemic fibrosis and its significance",
        "abstract": "Objective To investigate the expression and role of NF-\u03baB in rat's with myocardial ischemic fibrosis,and illuminate the relations between NF-\u03baB and occurrence and development of myocardial ischemic fibrosis. Methods 20male Wistar rats were randomly divided into control group,model group (12h,72hand 1week) (n=5),Except control group,all the rats in the other groups were treated with isoproterenol hydrochloride (2mg\u00b7kg-1).Conventional staining,immunohistochemical staining and Masson staining were used to analyze expression of NF-\u03baB protein in heart tissues.Results The results of HE staining showed the myocardium tissue had been a good order,the clear nuclear arms,no cell swollen.The mycardium presented many punctual necrosis at 12h.The myocardium appeared clear boundary and multi-radiations necrosis stove at 1week.The results of Masson staining showed the myocardium had only a small number of collagen in normal control group,the expression of collagen was obviously increased at 12h (P<0.01)and reached the arrived peakat1week.The results of NF-\u03baB protein expression showed there was positive matter of buff or yellow.The NF-\u03baB expression was increased obviously at 12hand reached the peak at 1week (P<0.05).Conclusion Along with,The NF-\u03baB expression is increased obviously which indicats that NF-\u03baB is involved in the occurrence and development of myocardial ischenic frbrosis in rats.with the prolongation of Iso injection time.",
        "keywords": [
            "transcription factor",
            "rats",
            "myocardial fibrosis",
            "wistar"
        ],
        "authors": [
            {
                "name": "JIANG Tie-chao",
                "org": ""
            },
            {
                "name": "ZOU Ying-gang",
                "org": ""
            },
            {
                "name": "YU Xiao-yan",
                "org": ""
            },
            {
                "name": "WANG Hong-zhi",
                "org": ""
            },
            {
                "name": "YANG Ping",
                "org": ""
            }
        ],
        "venue": "Journal of Jilin University(Medicine Edition)",
        "year": 2010
    },
    "XSRi0V2j": {
        "id": "XSRi0V2j",
        "title": "Myocardial infarction following a blunt chest trauma: A case report.",
        "abstract": "Owing to the first doctor's lack of experience and knowledge with this case, the patient was misdiagnosed and treatment was delayed, which subsequently led to heart failure.BCI can lead to myocardial infarction if patients are misdiagnosed and treatment is delayed. Thus, surgeons and physicians should consider cardiac complications in patients with chest trauma to reduce the incidence of its misdiagnosis.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiangdong Li",
                "org": "Cardiology Department."
            },
            {
                "name": "Zhiyuan Wang",
                "org": "Ultrasound Department, China-Japan Union Hospital of JiLin University, Changchun, Jilin, China."
            },
            {
                "name": "Yushuang Yang",
                "org": "Cardiology Department."
            },
            {
                "name": "Fanbo Meng",
                "org": "Cardiology Department."
            },
            {
                "name": "Yuquan He",
                "org": "Cardiology Department."
            },
            {
                "name": "Ping Yang",
                "org": "Cardiology Department."
            }
        ],
        "venue": "Medicine",
        "year": 2019
    },
    "VC0lVfzF": {
        "id": "VC0lVfzF",
        "title": "Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response",
        "abstract": "Objective: To determine the effect of atorvastatin on rat heart failure after myocardial infarction and to investigate the underlying mechanism of atorvastatin-mediated myocardium protection. Methods: Thirty-eight rats were randomly divided into three groups: a heart failure model group (model group), a heart failure plus atorvastatin treatment group (atorvastatin group) and a sham-surgery group (control group). The rat heart failure model was established by ligation of the left anterior descending of coronary arteries (LADs). Changes in hemodynamics parameters were recorded after the final drug administration. Plasma brain natriuretic peptide (BNP) concentration was determined by enzyme-linked immunosorbent assay (ELISA). Histological diagnosis was achieved by hematoxylin and eosin (H&E) and Masson's trichrome staining. The expressions of 78kDa glucose-regulated protein 78 (GRP78), caspase-12 and C/EBP homologous protein (CHOP, also known as GADD153) in myocardial cells and cultured cardiac myocytes were examined by Western blot. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) was used to evaluate myocardial cell apoptosis, and flow cytometry was performed to examine the cell apoptosis of cultured cardiac myocytes. Results: In the atorvastatin group, myocardial cells were lined up more orderly and myocardial fibrosis level was decreased compared to the model group. The expressions of GRP78, caspase-12 and CHOP in myocardial cells were decreased in atorvastatin group. Moreover, in the atorvastatin-treated group the cell apoptosis rate was reduced and the endoplasmic reticulum (ER) stress was activated in response to heart failure and angiotensin II(Ang II) stimulation. Conclusions: By down-regulating GRP78, caspase-12 and CHOP expressions in myocardial cells in rat heart failure after myocardial infarction, atorvastatin treatment decreased the apoptosis of myocardial cells, suggesting the possible mechanism by which atorvastatin functions in protecting against heart failure. \u00a9 Ivyspring International Publisher.",
        "keywords": [
            "apoptosis",
            "atorvastatin",
            "er stress response",
            "heart failure",
            "myocardial infarction",
            "heat shock proteins"
        ],
        "authors": [
            {
                "name": "Xian Jing Song",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Chun Yan Yang",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Bin Liu",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Qun Wei",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Melvin T. Korkor",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Jie Yu Liu",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Ping Yang",
                "org": "Jilin University(Jilin University),Changchun,China"
            }
        ],
        "venue": "International Journal of Medical Sciences",
        "year": 2011
    },
    "g5YCcGo3": {
        "id": "g5YCcGo3",
        "title": "Effect of atorvastatin and coenzyme Q10 on the oxidation and myocardial remodeling in heart failure rats",
        "abstract": "Objective To investigate the mechanism and effects of atorvastatin and coenzyme Q10 on the oxidation and myocardial remodeling in heart failure rats after myocardial infarction(MI).Methods The rat model of heart failure was established by left anterior descending coronary artery deligation.After 6 w,24 surviving rats were divided into sham,model,atorvastatin and atorvastatin+coenzyme groups at random,6 rats in each,and were treated with medicines by intragastric administration respectively.At 5 w,the activity of serum superoxide dismutase(SOD) and the content of serum malondialdehyde(MDA) were measured.The heart weight(HW)and left ventricular heart weight(LVHW)were weighed.HW/ BW and LVHW/BW were calculated.Furthermore,the level of uncoupling proteins 2(UCP2) was detected.Results Atorvastatin association with coenzyme Q10 increased the activity of serum superoxide dismutase,whereas decreased significantly the content of MDA in serum and myocardial hypertrophy index,downregulated the expression of UCP2.Conclusions Atorvastatin association with coenzyme Q10 has improve ventricular remodeling by downregulating the expression of UCP2 on heart failure after AMI in rats,which might be related to scavenging the oxygen free radicals formed.",
        "keywords": [
            "Heart failure",
            "Uncoupling proteins 2",
            "Atorvastatin",
            "Coenzyme Q10"
        ],
        "authors": [
            {
                "name": "ZHAO Dong-Ming",
                "org": ",et al. Department of Cardiology,China-Japan Union Hospital,Jilin University,Changchun ,Jilin,China"
            },
            {
                "name": "YANG Ping",
                "org": ",et al. Department of Cardiology,China-Japan Union Hospital,Jilin University,Changchun ,Jilin,China"
            },
            {
                "name": "YANG Jie",
                "org": ",et al. Department of Cardiology,China-Japan Union Hospital,Jilin University,Changchun ,Jilin,China"
            }
        ],
        "venue": "Chinese Journal of Gerontology",
        "year": 2013
    },
    "IPYHgRW0": {
        "id": "IPYHgRW0",
        "title": "Flow cytometry for assessing platelet activation in Patients with Acute Coronary Syndrame",
        "abstract": "Objective To assess the significance of platelet activation in patients with acute coronary syndrome by flow cytometry(FCM), and the correlation between two the platelet activation and endodermis function damage. Methods CD62p, CD61 from whole-blood samples were measured by FCM in 20 normal people and 36 patients with ACS before and after treatment, and the vWF were measured by Enzyme-Linked Immune Sorbent Assay. Results The platelet CD62p expression in ACS patients is evidently higher than that of normal peoples(P<0.05). The corresponding level variation is in agreement with the vWF and improment of angina and ST-T. However, the platelet CD61 expression in ACS patients has little increase than that of normal people(P>0.05), which hardly has change after treatment. Conclusion FCM is an accurate and reliable technique for measuring the platelet activation. CD62p is the sensitive index of platelet activation, which is agreement with the endodermis function damage.",
        "keywords": [
            "acute coronary syndrome",
            "CD62p",
            "von Wille-branfactor",
            "flow cytometry",
            "CD61"
        ],
        "authors": [
            {
                "name": "ZHOU Xue-yan",
                "org": "China-Japan Union Hospital of Jilin University, Changchun , China"
            },
            {
                "name": "GAO Shen",
                "org": "China-Japan Union Hospital of Jilin University, Changchun , China"
            },
            {
                "name": "YANG ping",
                "org": "China-Japan Union Hospital of Jilin University, Changchun , China"
            }
        ],
        "venue": "Chinese Journal of Laboratory Diagnosis",
        "year": 2005
    },
    "BFGrpxRz": {
        "id": "BFGrpxRz",
        "title": "Changes of Vascular Endothelial Cell Function in Patients With Viral Myocarditis by High Resolution Ultrasonography",
        "abstract": "Objective:To investigate the flow-mediated brachial artery dilation(FMD)and nitroglycerin-mediated brachial artery dila- tion(NMD)in patients with viral myocarditis by high resolution ultrasonography. Methods:The vascular endothelial cell function was examined by high resolution ultrasonography and the comparison was conducted in three groups.Viral myocarditis group:n=30(myocarditis group),non-viral myocarditis group:n=20(non-myo- carditis group)and normal control gronp:n=20. Results:The FMD in myoearditis group was(8.73\u00b12.87)% and in non-myoearditis group was(13.00\u00b12.79)%,which were both decreased than that of in normal control group(19.32\u00b12.67)%,the distinct difference(P<0.01)had the statistic meaning.The FMD in myocarditis group was significantly decreased than that in non-myoearditis group(P<0.01).The NMD in myocarditis group was(19.68\u00b15.84)%,in non-myoearditis group was(23.18\u00b14.28)%,and in normal control group was (24.24\u00b14.13)%,no statistic difference was found among three groups(P>0.05). Conclusions:FMD was impaired in patients with viral myocarditis,while NMD was not significantly affected.",
        "keywords": [
            "Brachial artery flow-mediated dilation",
            "High resolution ultrasonography",
            "Viral myocarditis"
        ],
        "authors": [
            {
                "name": "KANG Yu-guang",
                "org": ".Department of Cardiology,China-Japan Union Hospital of Jilin University,Changchun%%#%%#,Jili,China Now Working in the Third People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine"
            },
            {
                "name": "YANG Ping",
                "org": ".Department of Cardiology,China-Japan Union Hospital of Jilin University,Changchun%%#%%#,Jili,China Now Working in the Third People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine"
            },
            {
                "name": "YU Jie",
                "org": ".Department of Cardiology,China-Japan Union Hospital of Jilin University,Changchun%%#%%#,Jili,China Now Working in the Third People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine"
            }
        ],
        "venue": "Chinese Circulation Journal",
        "year": 2008
    },
    "ngJpkO0o": {
        "id": "ngJpkO0o",
        "title": "Association study of CD36 single nucleotide polymorphisms with essential hypertension in the Northeastern Han Chinese.",
        "abstract": "We found that cluster determinant 36 (CD36) gene is up-regulated in essential hypertension (EH) patients in our former research, but the association between CD36 gene variations and EH has not yet been clearly demonstrated. The relationship between CD36 gene single nucleotide polymorphisms (SNPs) and EH in the northeastern Han Chinese was examined in the present study through direct sequencing and genotype-detection. A total of 589 unrelated northeastern Han Chinese including 276 with EH and 313 controls were studied. SNPs in exon 7, exon 13 and intron 4 were detected using PCR-sequencing. The genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) or polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP). +216T/C, +273A/G, +132C/T, +217T/C, +212T/G and +233T/C polymorphisms were identified. Distributions of genotypes AA, GA and GG of +273A/G polymorphism were significantly different between EH group and the control group (\u03c72: 9.056, p=0.011) and G allelic frequency was higher in EH (p=0.006, OR=1.629, 95% CI [1.224-2.168]). Logistic regression analysis showed that +273A/G polymorphism was closely associated with blood pressure (BP) after adjusting for ages. When subclassified by sex, the genotype distribution of +273A/G (p=0.011) and allelic frequency of G allele (p=0.006) were significantly different between EH participants and controls in males, but not in females. Subgroup analysis performed by body mass index (BMI) suggested that the genotype distribution of +273A/G and allelic frequency were significantly different in non-obese group and non-obese men, but the associations were not significant (non-obese group: p=0.016, OR=1.664, 95% CI [1.459-2.409]; non-obese men: p=0.073, OR=1.898, 95% CI [1.033-3.487]). +273A/G polymorphism in CD36 gene was associated with EH, and +273G could be an independent predictor.",
        "keywords": [
            "bmi",
            "bp",
            "bun",
            "cd36",
            "ci",
            "comparative study",
            "eh",
            "essential hypertension",
            "fa",
            "fbg",
            "genetics",
            "hdl-c",
            "ldl",
            "ldl-c",
            "molecular marker",
            "or",
            "pcr-rflp",
            "pcr-sscp",
            "scr",
            "snp",
            "single nucleotide polymorphism",
            "tc",
            "tg",
            "blood pressure",
            "blood urea nitrogen",
            "body mass index",
            "cluster determinant 36",
            "confidence intervals",
            "fasting blood glucose",
            "fatty acids",
            "high density lipoprotein cholesterol",
            "low density lipoprotein",
            "low density lipoprotein cholesterol",
            "odds ratio",
            "oxldl",
            "oxidized low density lipoprotein",
            "polymerase chain reaction-restriction fragment length polymorphism",
            "polymerase chain reaction-single strand conformation polymorphism",
            "serum creatinine",
            "total cholesterol",
            "triglyceride"
        ],
        "authors": [
            {
                "name": "Xueyan Liu",
                "org": "Department of Internal Medicine and Cardiology, China-Japan Union Hospital, Norman Bethune College of Medicine, Jilin University, China."
            },
            {
                "name": "Fanbo Meng",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            }
        ],
        "venue": "Gene",
        "year": 2013
    },
    "ez5923tI": {
        "id": "ez5923tI",
        "title": "Expression of PPAR-\u03b3 in a rabbit model of atherosclerosis and the effect of atorvastatin",
        "abstract": "Objective To investigate the expression of peroxisome proliferator-activated receptor-\u03b3(PPAR-\u03b3)in a rabbit model of atherosclerosis,and the effect of atorvastatin.Methods Twenty-four male Japanese rabbits were separated into 3 groups(8 in each group),which were high-fat diet group(group A),high-fat plus atorvastatin group(group B)and normal diet group(group C).All the animals were sacrificed after 16 weeks.The expression of PPAR-\u03b3 was detected with immunohistochemical assay,and plasma lipid with automatic biochemical analysis device.Results The expression of PPAR-\u03b3 were,respectively,high-fat diet group(11.23\u00b11.21)%,high-fat plus atorvastatin diet group(11.05\u00b11.02)% and normal diet group(7.68\u00b11.04)%.Between group A and B there wasn\u2019t any significant difference(P >0.05).Meanwhile,they both had significant differences compared with group C(P <0.01).TC and LDL expression both had significant differences among three groups,while TG had no significant difference.Conclusion The expression of PPAR-\u03b3 increases in a rabbit model of atherosclerosis;atorvastatin increases the expression of PPAR-\u03b3.",
        "keywords": [
            "Atherosclerosis",
            "Lipid",
            "Atorvastatin",
            "PPAR-gamma"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": ".Department of Cardiology,the Third Hospital of Jilin University,Changchun ,China"
            },
            {
                "name": "LI Xue-yu",
                "org": ".Department of Cardiology,the Third Hospital of Jilin University,Changchun ,China"
            },
            {
                "name": "QIN Ling",
                "org": ".Department of Cardiology,the Third Hospital of Jilin University,Changchun ,China"
            }
        ],
        "venue": "Chinese Journal of Practical Internal Medicine",
        "year": 2007
    },
    "tIDIbrD9": {
        "id": "tIDIbrD9",
        "title": "Study of predict value of ankle-brachial index in patients suffer from coronary disease",
        "abstract": "Objective This study aimed to examine the relation between ABI and the extent of the patient with angina pectoris.Methods We studied 106 patients who were hospitalized patients with angina cordis elected.All be measured ABI with desk model sphygmomanometer before coronary angiography,and collect the history,blood biochemistry result,coronary angiography result,and analyze the dependablity between ABI and the extent of coronary stenosis.Results There were significant differences between ABI of 3-vessel disease(0.81\u00b10.18) and 1-vessel disease(0.98\u00b10.12,P<0.05),normal group(1.07\u00b10.16) P\u22640.05;There were significant differences between ABI of 2-vessel disease(0.87\u00b10.20)and normal group(1.07\u00b10.16,P<0.01);There were significantly negative dependability between the LNCCS and ABI.Conclusion Measurement of ABI with desk model sphygmomanometer is simple,inexpensive,and noninvasive,it very suitable for basic level hospital.",
        "keywords": [
            "CHD",
            "Coronary angiography",
            "Ankle-brachial index(ABI)"
        ],
        "authors": [
            {
                "name": "WU Yuan",
                "org": "Department of Cardiology China-Japan Union Hospital,Jilin University,Changchun ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Cardiology China-Japan Union Hospital,Jilin University,Changchun ,China"
            }
        ],
        "venue": "Chinese Journal of Laboratory Diagnosis",
        "year": 2009
    },
    "tG3LS04M": {
        "id": "tG3LS04M",
        "title": "Essential Role of RyR2 Phosphorylation in the Effect of Azumolene on Ventricular Arrhythmia Vulnerability in a Rabbit Heart Model.",
        "abstract": "Ventricular refibrillation following long-duration VF was reduced by azumolene, which also improves calcium dynamics. RyR2 phosphorylation at Ser2808 is a prerequisite for the beneficial effects of azumolene. This article is protected by copyright. All rights reserved.",
        "keywords": [
            "azumolene",
            "cardiac intracellular calcium dynamics",
            "phosphorylation",
            "ryanodine receptor",
            "ventricular refibrillation"
        ],
        "authors": [
            {
                "name": "Daoyuan Si",
                "org": "Department of Cardiology, China-Japan Union Hospital, Jilin University, Changchun, China."
            },
            {
                "name": "Mohammed Ali Azam",
                "org": "The Hull Family Cardiac Fibrillation Management Laboratory, Toronto General Hospital."
            },
            {
                "name": "Patrick F H Lai",
                "org": "The Hull Family Cardiac Fibrillation Management Laboratory, Toronto General Hospital."
            },
            {
                "name": "Nima Zamiri",
                "org": "The Hull Family Cardiac Fibrillation Management Laboratory, Toronto General Hospital."
            },
            {
                "name": "Galina Kichigina",
                "org": "The Hull Family Cardiac Fibrillation Management Laboratory, Toronto General Hospital."
            },
            {
                "name": "John Asta",
                "org": "The Hull Family Cardiac Fibrillation Management Laboratory, Toronto General Hospital."
            },
            {
                "name": "St\u00e9phane Mass\u00e9",
                "org": "The Hull Family Cardiac Fibrillation Management Laboratory, Toronto General Hospital."
            },
            {
                "name": "Mahmoud M Bokhari",
                "org": "The Hull Family Cardiac Fibrillation Management Laboratory, Toronto General Hospital."
            },
            {
                "name": "Andreu Porta-S\u00e1nchez",
                "org": "The Hull Family Cardiac Fibrillation Management Laboratory, Toronto General Hospital."
            },
            {
                "name": "Christopher Labos",
                "org": "University Health Network, Toronto, Ontario, Canada."
            },
            {
                "name": "Huan Sun",
                "org": "Department of Cardiology, China-Japan Union Hospital, Jilin University, Changchun, China."
            },
            {
                "name": "Ping Yang",
                "org": "Department of Cardiology, China-Japan Union Hospital, Jilin University, Changchun, China."
            },
            {
                "name": "Kumaraswamy Nanthakumar",
                "org": "The Hull Family Cardiac Fibrillation Management Laboratory, Toronto General Hospital."
            }
        ],
        "venue": "Journal of cardiovascular electrophysiology",
        "year": 2018
    },
    "u431B9G2": {
        "id": "u431B9G2",
        "title": "Mechanism and clinical significance of the prothrombotic state in patients with essential hypertension.",
        "abstract": "Thrombotic, rather than hemorrhagic, events represent a major complication of hypertension. This study aims to explore the mechanism of the hypercoagulative state in hypertension and to assess its clinical significance.The hypercoagulative state and even the prothrombotic state exists in patients with hypertension. This may be attributed to an impairment of the endothelium.A total of 81 patients suffering from essential hypertension were classified into 3 groups (grade 1: n = 27; grade 2: n = 36; grade 3: n = 18) and an additional 28 nonhypertensive patients were used as the control group. This study determined the changes of platelet activation marker P-selectin (CD62P), plasma fibrinogen, plasminogen activitor inhibitor-1 (PAI-1), and endothelium function.The percentage of CD62P+ platelets and the concentration of plasma fibrinogen and PAI-1 in the hypertension group was significantly higher than those in the control group. These increments coincided with the elevation of blood pressure. A significant difference was found between any of the 2 hypertension subgroups in the percentages of CD62P+ platelets (P < 0.001) and the concentration of PAI-I (P < 0.05). No difference was noted between the hypertension grade 1 and 2 groups in the concentration of plasma fibrinogen (P = 0.079); however, a significant difference was found between any of the other 2 subgroups (P < 0.001). Flow-mediated dilation (FMD) in the hypertension group was significantly lower than that in the control group.The hypercoagulative state exists in patients with hypertension and this state was more obvious with the elevation of blood pressure and coincided with an impairment in the degree of endothelium-dependent vasodilation.",
        "keywords": [],
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Ya-Fen Liu",
                "org": ""
            },
            {
                "name": "Li Yang",
                "org": ""
            },
            {
                "name": "Qun Wei",
                "org": ""
            },
            {
                "name": "Hong Zeng",
                "org": ""
            }
        ],
        "venue": "Clinical cardiology",
        "year": 2010
    },
    "J3eGhkIg": {
        "id": "J3eGhkIg",
        "title": "Preliminary observation of regressive effect of atorvastatin on aorta atherosclerosis in rabbits",
        "abstract": "[Objective] To determine the effect of atorvastatin on aorta expression of plasminogen activator inhibitor type1-1(PAI-1)and it/s mechanism of anti-atherosclerosis in atheroclerosis rabbits fed with cholesterol-enriched diet. [Methods] Twenty four rabbits were randomly divided into control, cholesterol diet and atorvastatin group, which were fed for 16 weeks. Serum TC, LDL and weigh were measured in 0 and 16 weeks in the three groups. The aortas were harvested for pathologic morphology observation, immunohistochemistry analysis of PAI-1 positive percentages was performed. [Results] After 16 weeks TC and LDL in atorvastatn group were greatly lower than that cholesterol diet group (P <0.01), they were (23.51\u00b110.58) mmol/L and (14.27\u00b13.51) mmol/L(P <0.01), (21.39\u00b110.00) mmol/L vs (14.23\u00b14.01) mmol/L (P <0.01). The aortas plaque/intima size (P/I) was 0, (0.28\u00b10.37) vs (0.16\u00b10.27) in control, cholesterol diet group and atorvastatn group by pathologic nakey observation(P <0.01), intima thickness was (4.45\u00b10.58) \u03bcm, (67.47\u00b17.13) \u03bcm and (38.11\u00b16.02) \u03bcm, intima/medium thickness ratio(I/M) was (0.0537\u00b10.007), (0.878\u00b10.370) and (0.391\u00b10.213) in the three groups by microscope(P <0.01). The expressions of immunohistochemistry analysis of PAI-1 in cholesterol diet group and atorvastatin group were higher than that control(P <0.01), but the expression reduced in atorvastatin group (P <0.01). [Conclusion] Atorvastatin has anti-atherosclerosis effect except reducing serum lipids, the inhibition of PAI-1 excessively expression may be one of the anti-atherosclerosis mechanism.",
        "keywords": [
            "plasminogen activator inhibitor type1-1",
            "atorvastatin",
            "atherosclerosis"
        ],
        "authors": [
            {
                "name": "QIN Ling",
                "org": "Department of Cardiology, the First Hospital, Jilin University, Changchun, Jilin , P.R.China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Cardiology, the Third Hospital, Jilin University, Changchun, Jilin , P.R.China"
            },
            {
                "name": "ZHU Yan",
                "org": "Department of Internal Medicine, Jilin Qianwei Hospital, Changchun, Jilin , P.R.China"
            }
        ],
        "venue": "China Journal of Modern Medicine",
        "year": 2006
    },
    "yiKuYrVh": {
        "id": "yiKuYrVh",
        "title": "Immunogenicities of HBV DNA and recombinant modified vaccinia Ankara-based HB vaccines",
        "abstract": "Objective: To compare the immunogenicities of HBV DNA and recombinant modified vaccina Ankara (rMVA)-based HB vaccines. Methods: Immunize BALB/c mice with rMVA-based HB vaccine and HBV DNA vaccine respectively, then determine the humoral immune response by ELISA, and cellular immune response by ELISPOT. Results: The serum HB antibody levels of mice immunized with rMVA-based HB vaccine and HBV DNA vaccine were 135 and 104 mIU/ml, and the numbers of spot-forming cells(SFC) were 550 and 314 cells per 106 lymphocytes respectively. Conclusion: rMVA-based HB vaccine was more immunogenic than HBV DNA vaccine.",
        "keywords": [
            "DNA vaccine",
            "Hepatitis B virus",
            "Immunogenicity",
            "Vector-based vaccine"
        ],
        "authors": [
            {
                "name": "Yu Chen",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "YANG Xiao-song",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Ping Yang",
                "org": "Jilin University(Jilin University),Changchun,China"
            }
        ],
        "venue": "Chinese Journal of Biologicals",
        "year": 2007
    },
    "LtgtR5Hf": {
        "id": "LtgtR5Hf",
        "title": "Association of single nucleotide polymorphisms in the 3'UTR of ERAP1 gene with essential hypertension in the Northeastern Han Chinese.",
        "abstract": "Endoplasmic reticulum aminopeptidase 1 (ERAP1) may be involved in blood pressure regulation by inactivation of angiotensin II and generation of bradykinin. Our previous study with cDNA microarray indicated that the expression of ERAP1 is down-regulated in essential hypertension (EH) patients. Since the 3'untranslated region (3'UTR) is known to play an important role in the post-transcriptional regulation by influencing the stability and translation process of mRNA, the present study aims to identify single nucleotide polymorphisms (SNPs) in the 3'UTR of ERAP1 gene in a case-control study among the Northeastern Han Chinese through PCR-sequencing, and analyze the association with EH. Our results further verified the lower expression level of ERAP1 in the peripheral blood cells in patients with EH (917.12\u00b1517.57 vs. 1506.59\u00b11214.09pg/mL, P=0.011). Four SNPs, 3'UTR-761G>A, 3'UTR-787C>T, 3'UTR-1008A>C and 3'UTR-1055A>G, were identified in the 3'UTR of ERAP1. 3'UTR-1008A>C and 3'UTR-1055A>G were in almost complete linkage disequilibrium. Association analysis showed that the genotypic and allelic frequencies of 3'UTR-1008A>C and 3'UTR-1055A>G were significantly different between EH and the control groups. Logistic regression and haplotypic analysis indicated that alleles of E20-1037C and E20-1084G as well as haplotype of C-G were the risk factors of EH (P<0.05). Subgroup analysis performed by age suggested that the frequencies of genotype and allele of 3'UTR-1008A>C and 3'UTR-1055A>G as well as the haplotypes C-G and A-A were significantly different between EH and the control in the younger group (<50), but not in the older group (\u226550). Younger population with the 3'UTR-1008CC and/or 3'UTR-1055GG genotypes also tended to have higher blood pressure, especially the diastolic blood pressure. In conclusion, the 3'UTR-1008A>C and 3'UTR-1055A>G polymorphisms of ERAP1 gene were associated with EH, especially in the younger population, and the haplotype C-G could be the independent marker of EH.",
        "keywords": [
            "association study",
            "endoplasmic reticulum aminopeptidase 1",
            "essential hypertension",
            "single nucleotide polymorphism"
        ],
        "authors": [
            {
                "name": "Sibao Yang",
                "org": "Department of Cardiology, China-Japan Union Hospital, Jilin University, Changchun, China."
            },
            {
                "name": "Xueyan Liu",
                "org": "Department of Cardiology, China-Japan Union Hospital, Jilin University, Changchun, China."
            },
            {
                "name": "Yongjian Gao",
                "org": "Department of Gastrointestinal Surgery, China-Japan Union Hospital, Jilin University, Changchun, China."
            },
            {
                "name": "Mei Ding",
                "org": "Department of Cardiology, China-Japan Union Hospital, Jilin University, Changchun, China."
            },
            {
                "name": "Bing Li",
                "org": "Department of Cardiology, China-Japan Union Hospital, Jilin University, Changchun, China."
            },
            {
                "name": "Huan Sun",
                "org": "Department of Cardiology, China-Japan Union Hospital, Jilin University, Changchun, China."
            },
            {
                "name": "Yuquan He",
                "org": "Department of Cardiology, China-Japan Union Hospital, Jilin University, Changchun, China."
            },
            {
                "name": "Ping Yang",
                "org": "Department of Cardiology, China-Japan Union Hospital, Jilin University, Changchun, China."
            }
        ],
        "venue": "Gene",
        "year": 2015
    },
    "eUp4NTlY": {
        "id": "eUp4NTlY",
        "title": "The mechanism of microRNAin the pathology of coronary atherosclerosis",
        "abstract": "Small, noncoding microRNAs have emerged as key mediators of posttranscriptional gene silencing in the pathology of coronary atherosclerosis. The microRNAs play an important role in the etiology and pathophysiology of coronary atherosclerosis through modulating the functions and morphology of related cells, such as endothelial cells, vascular smooth muscle cells, macrophages and monocytes, by regulating lipid metabolism, chronic inflammation and the accumulation and activation of platelets. Researches in the mechanisms of coronary atherosclerosis regulation of microRNAs can not only provide a new era in disease research, but also provide basic knowledge for the development of novel therapies for coronary atherosclerosis and other cardiovascular disease.",
        "keywords": [
            "Coronary atherosclerosis",
            "Genetic regulation",
            "microRNA"
        ],
        "authors": [
            {
                "name": "LIU Xueyan",
                "org": "Department of Cardiology, China-Japan Union hospital of Jilin University, Jilin ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Cardiology, China-Japan Union hospital of Jilin University, Jilin ,China"
            }
        ],
        "venue": "Chinese Journal of the Frontiers of Medical Science(Electronic Version)",
        "year": 2013
    },
    "oJ4uCmHS": {
        "id": "oJ4uCmHS",
        "title": "Study and use of Mycelium-1/4 KPYG_2 Gel containing the mosquito-killing fungus Pythium sp.GY1938",
        "abstract": "Objective To explore the best method of preparing a gel containing the mosquito-killing fungus Pythium sp.GY1938.Methods Based on aspects of mosquito development and the biological characteristics of Pythium sp.GY1938,Mycelium-1/4 KPYG2 Gel was prepared using solid medium with 1/2 KPYG2 containing trehalose as a carrier and Pythium sp.GY1938 mycelia as the active ingredient.Storage,transportation,and ease of use were considered.The fungus' effectiveness at killing mosquitoes was also determined in experiments and simulations of outdoor conditions.Results In the lab and simulations,2 slabs of gel(1.5\u00d71.5\u00d71.0 cm3) per 100 ml water killed as many as 28% of mosquitoes in 7 d.The gel remained effective when kept for 6 mo at 4-8 \u2103.Conclusion Mycelium-1/4 KPYG2 Gel does not cause contamination and is promising because it is simple to produce and easy to use.",
        "keywords": [
            "mosquito-killing fungus",
            "Mycelium",
            "preparation",
            "gel"
        ],
        "authors": [
            {
                "name": "LI Min-hui",
                "org": "Center for Science and Research,Chengdu Medical College,Chengdu ,China"
            },
            {
                "name": "PAN Ke-jian",
                "org": "Department of Biomedicine,Chengdu Medical College,Chengdu ,China"
            },
            {
                "name": "SU Xiao-qing",
                "org": "Department of Biology,Guiyang Medical College,Guiyang ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Biomedicine,Chengdu Medical College,Chengdu ,China"
            }
        ],
        "venue": "Journal of Pathogen Biology",
        "year": 2012
    },
    "Z8T8VASU": {
        "id": "Z8T8VASU",
        "title": "Comparison and Research of Several Analytic Methods on the Genic Differences",
        "abstract": "The separation and identification of genic differences will be helpful for obtaining the functional genes, unveiling the evolutionary rule of species and elucidating the mechanism of those genes related to diseases. The principles, applicability and compare of their advantages and disadvantages of several analytic methods on the genic differences, especially a new method called hybridization-monitored differential analysis, HMDA were briefly reviewed in this paper. The technique breakthrough and research foreground on genomic differences with HMDA were also discussed.",
        "keywords": [
            "genome",
            "genic differences",
            "hybridization-monitored differential analysis"
        ],
        "authors": [
            {
                "name": "LI Min-hui",
                "org": " a. Science Research Center"
            },
            {
                "name": "YANG Ping",
                "org": " a. Science Research Center"
            },
            {
                "name": "CAO Yue-qing",
                "org": " Genetic Engineering Research Center of Bioengineering Institute, Chongqing University, Chongqing "
            }
        ],
        "venue": "Letters in Biotechnology",
        "year": 2006
    },
    "BiH52Dlb": {
        "id": "BiH52Dlb",
        "title": "Expression and molecular characterization of zebrafish rnf141 gene",
        "abstract": "Objective: To explore the molecular evolution of zebrafish rnf141 gene and its expression in the embryo and adult zebrafish. Methods: The molecular characteristics of zebrafish rnf141 gene were analyzed through a bioinformatics approach. Expression of rnf141 gene in the embryos of different developmental stages and tissues of adult fish were examined by whole-mount in situ hybridization and multiple-tissue RT-PCR technique. Results: We noticed that zebrafish RNF141 protein shared a 79.8% and 78.5% homologies to its homologues in human and mouse (ZNF230, Znf230), respectively, especially that the C3HC4-type domain and the same conserved cysteine and histidine residues shared a 84.8% and 100% homologies to its homologues in human or mouse. Moreover, the secondary structure of C3HC4-type domain in zebrafish RNF141 protein was the same as that in its human homologue. Whole-mount in situ hybridization showed that zebrafish rnf141 gene expressed ubiquitously during embryogenesis, with higher expression found in the telencephalon, cerebellum and hindbrain. RT-PCR revealed rnf141 gene expression in all the adult tissues detected, and abundance was observed in the testicular tissue. Conclusion: These data suggest that zebrafish rnf141 gene is conservative in the vertebrate and might play important roles in embryogenesis and spermatogenesis.",
        "keywords": [
            "rnf141",
            "Whole-mount in situ hybridization",
            "Zebrafish"
        ],
        "authors": [
            {
                "name": "Ya Li",
                "org": "Chengdu Medical College(Chengdu Medical College,Chengdu Geological College),Chengdu,China"
            },
            {
                "name": "WANG Lun-an",
                "org": "Chengdu Medical College(Chengdu Medical College,Chengdu Geological College),Chengdu,China"
            },
            {
                "name": "WANG Yu-ming",
                "org": "Chengdu Medical College(Chengdu Medical College,Chengdu Geological College),Chengdu,China"
            },
            {
                "name": "Ping Yang",
                "org": "Chengdu Medical College(Chengdu Medical College,Chengdu Geological College),Chengdu,China"
            },
            {
                "name": "PAN Ke-jian",
                "org": "Chengdu Medical College(Chengdu Medical College,Chengdu Geological College),Chengdu,China"
            },
            {
                "name": "HUANG Ming-kong",
                "org": "Sichuan Cancer Hospital and Institute(Sichuan Cancer Hospital,Sichuan Cancer Institute),Chengdu,China"
            }
        ],
        "venue": "Academic Journal of Second Military Medical University",
        "year": 2008
    },
    "0TgzAUvM": {
        "id": "0TgzAUvM",
        "title": "A method for degenerate primer PCR extraction of genomic DNA from Pythium sp.GY1938",
        "abstract": "Objective To explore the best method for degenerate primer PCR extraction of genomic DNA from the Pythium sp.GY1938 strain.Methods Five methods were used to extract genomic DNA and their efficiency was separately evaluated with specific and degenerate primer PCR.Results Results of specific primer PCR showed that there were no significant differences in the five methods.However,results of degenerate primer PCR showed that the benzyl chloride method was more effective because it a larger number of clearer bands.Conclusion The benzyl chloride method was best suited to degenerate primer PCR extraction of genomic DNA from the Pythium sp.GY1938 strain.",
        "keywords": [
            "degenerate",
            "Fungi",
            "genomic DNA"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Department of Biochemistry,Chengdu Medical College,Chengdu ,China"
            },
            {
                "name": "HUANG Jie",
                "org": "Department of Biomedicine,Chengdu Medical College"
            },
            {
                "name": "YU Lin",
                "org": "Department of Biomedicine,Chengdu Medical College"
            },
            {
                "name": "DENG Wei",
                "org": "Department of Biomedicine,Chengdu Medical College"
            },
            {
                "name": "FU Long-zhang",
                "org": "Department of Biomedicine,Chengdu Medical College"
            },
            {
                "name": "LI Min-hui",
                "org": "Science and Research Center,Chengdu Medical College"
            }
        ],
        "venue": "Journal of Pathogen Biology",
        "year": 2012
    },
    "hbYgsB1y": {
        "id": "hbYgsB1y",
        "title": "Preparation and Characterization of IgY Antibody Against Cystatin C",
        "abstract": "Objective: To prepare high potent and specific IgY antibody against cystatin C.Methods: Hens were immunized with cystatin C as antigen and the antibody was purified through the water dilution and sodium sul phate salting-out methods from eggs.The antibody was characterized through methods including SDS-PAGE,West ern blot and ELISA.Results: Specific IgY antibody against cystatin C could be detected from the blood serum of chicken at 14 d post-immunization.The potency of antibody against cystatin C could reach the peak 1\u223632 000 at 28 d post-immunization and maintain high production in subsequent 2 months.The IgY antibody was purified when valence of antibody was at the peak.Reduced SDS-PAGE molecular weights of IgY were of around 65 and 21 kD respectively.Normally,36.5 mg IgY could be isolated from each egg yolk,the purity of IgY was 92% and the sensitivity detection for cystatin C was 15.63 ng/mL.Western blot showed the antibody has good specificity.Conclusion: High potent and specific IgY antibody against cystatin C which may be a novel and useful diagnosis reagent was successfully prepared in this study.",
        "keywords": [
            "cystatin C",
            "egg yolk",
            "IgY antibody"
        ],
        "authors": [
            {
                "name": "FU Long-Zhang",
                "org": ""
            },
            {
                "name": "LI Min-Hui",
                "org": "Center of Science and Research"
            },
            {
                "name": "PAN Ke-Jian",
                "org": ""
            },
            {
                "name": "ZOU Ke-Ke",
                "org": ""
            },
            {
                "name": "YANG Jun",
                "org": ""
            },
            {
                "name": "LI Yan-Chao",
                "org": ""
            },
            {
                "name": "HUANG Jie",
                "org": ""
            },
            {
                "name": "YE Qi-Di",
                "org": ""
            },
            {
                "name": "MA Ling-Ling",
                "org": ""
            },
            {
                "name": "YANG Ping",
                "org": "Department of Biochemistry"
            }
        ],
        "venue": "Letters in Biotechnology",
        "year": 2013
    },
    "z1doYQBR": {
        "id": "z1doYQBR",
        "title": "Insect Antimicrobial Peptides and Its Development on Genetic Engineering",
        "abstract": "Insect antimicrobial peptide is a kind of polypeptide which has the specific immunity from bacteria,fungi,virus and other pathogenic microorganisms.It has such characters as heat-durability,broad-spectrum antibiotic,no immunogen and spe- cific mechanism,et al.Recently,insect antimicrobial peptide has been widely used in the prevention and treatment of infectious diseases with the background and application research on it.This paper briefly reviews its classification its biological functions,the development on genetic engineering and the application in medicine.",
        "keywords": [
            "genetic engineering",
            "insect",
            "antimicrobial peptides"
        ],
        "authors": [
            {
                "name": "LI Min-hui",
                "org": "Chengdu Medical College,1.Science Research Center"
            },
            {
                "name": "YANG Ping",
                "org": "Biochemistry Department,Chengdu ,China"
            }
        ],
        "venue": "Journal of Chengdu Medical College",
        "year": 2006
    },
    "gXio5oAe": {
        "id": "gXio5oAe",
        "title": "Research on the inhibition of IFN-\u03b3 secretion in mouse splenic lymphocytes by exoproteins of Stenotrophomonas maltophilia",
        "abstract": "Objective To examine the effects of exoproteins of Stenotrophomonas maltophilia on cytokine secretion in splenic lymphocytes of mice.Methods Double antibody sandwich ELISA was used to detect changes in the secretion of IL-2,IL-4,and IFN-\u03b3 induced by secreted exoproteins of S.maltophilia in splenic lymphocytes of mice that were activated by ConA for 24 h~48 h at 37 \u2103.Results The C1 components of secreted exoproteins of S.maltophilia inhibited the secretion of IFN-\u03b3 in activated splenic lymphocytes of mice.Conclusion The inhibition of IFN-\u03b3 secretion in lymphocytes may be one of the mechanisms of pathogenicity of S.maltophilia.",
        "keywords": [
            "IFN-\u03b3",
            "exoprotein",
            "ELISA",
            "Stenotrophomona maltophilia"
        ],
        "authors": [
            {
                "name": "ZOU Ke-ke",
                "org": "Department of Biomedicine,Chengdu Medical College,Chengdu ,China"
            },
            {
                "name": "ZOU Qiang",
                "org": "Center for Science and Research,Chengdu Medical College"
            },
            {
                "name": "LI Li-mei",
                "org": "Center for Science and Research,Chengdu Medical College"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Biochemistry,Chengdu Medical College"
            },
            {
                "name": "SHEN Xiao-xu",
                "org": "Department of Biomedicine,Chengdu Medical College,Chengdu ,China"
            },
            {
                "name": "CHEN Zi-min",
                "org": "Department of Biomedicine,Chengdu Medical College,Chengdu ,China"
            },
            {
                "name": "SONG Li-ping",
                "org": "Department of Biomedicine,Chengdu Medical College,Chengdu ,China"
            },
            {
                "name": "JIANG Hong-jiao",
                "org": "Department of Biomedicine,Chengdu Medical College,Chengdu ,China"
            },
            {
                "name": "LI Min-hui",
                "org": "Center for Science and Research,Chengdu Medical College"
            }
        ],
        "venue": "Journal of Pathogen Biology",
        "year": 2013
    },
    "ciZ6yhnZ": {
        "id": "ciZ6yhnZ",
        "title": "The Inhibitory Effect of Antisense Oligonucleotide Targeting Survivin to the Proliferation of SW480 Cells",
        "abstract": "Objective: To investigate the effect of survivin antisense oligonucleotide(ASODN) to the proliferation of SW480 cells.Mathods: A human ASODN was designed,synthesized,and transfected into SW480 cells.Expression of survivin in SW480 cells was detedted with RT-PCR and western blot.The inhibition of cell proliferation by ASODN was demonstrated with MTT assay.A nonsense oligonucleotide fragment(SODN) was designed as one control.Results: The expression of survivin mRNA and protein in ASODN treated group was significantly lower than that in control groups.Conclusion: ASODN can knock-down survivin expression in SW480 cells and inhibit cell proliferation.It's promising to use ASODN in adjunctive therapy of human colon carcinoma.",
        "keywords": [
            "colonic neoplasms",
            "antisense",
            "survivin",
            "oligonucleotides",
            "carcinoma"
        ],
        "authors": [
            {
                "name": "PAN Kejian",
                "org": "Department of Biochemistry,Chengdu Medical College,Chengdu ,Sichuan,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Biochemistry,Chengdu Medical College,Chengdu ,Sichuan,China"
            },
            {
                "name": "WANG Yuming",
                "org": "Department of Biochemistry,Chengdu Medical College,Chengdu ,Sichuan,China"
            },
            {
                "name": "WANG Xiyan",
                "org": "Training Center for Clinical Techniques,Chengdu Medical College,Chengdu ,Sichuan,China"
            }
        ],
        "venue": "Journal of Guiyang Medical College",
        "year": 2007
    },
    "a0z345pM": {
        "id": "a0z345pM",
        "title": "Cloning and Sequence Analysis of Subtilisin-like Protease Pr1 Gene from Pythium sp.GY1938",
        "abstract": "Objective To obtain the full-length genomie DNA sequence of the subtilisin-like protease(Pr1)gene from Pythium sp.GY1938.Methods Basing on the obtained cDNA sequence of the Prl from Pythium sp.GY1938,a genomic DNA fragment corresponding to the cDNA was amplified by PCR firstly.Then the upstream and downstream unknown fragments were respectively cloned by mini genomic DNA library,and panhandle PCR methods.In the end,the gene fragment of the Pr1 was amplified by PCR.Results A 1 519bp DNA fragment called YP1977,in which there is a 969bp ORF coding 323 amino acids analysed by DNAassist software,of subtilisin-like protease gene from Pythium sp.GY1938 was obtained.Conclusion The fragment, YP1977,is the Pr1 gene from Pythium sp.GY1938 in all probaability.However,it must be validated further by the construction of expression system.",
        "keywords": [
            "clone",
            "genomic DNA library",
            "panhandle PCR",
            "Subtilisin-like protease"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Chengdu Medical College a. Department of Biochemistry,b. Scientific Research Center,Chengdu ,China"
            },
            {
                "name": "LI Min-hui",
                "org": "Chengdu Medical College a. Department of Biochemistry,b. Scientific Research Center,Chengdu ,China"
            },
            {
                "name": "SU Xiao-qing",
                "org": "Department of Biology,Guiyang Medical College,Guiyang ,China"
            }
        ],
        "venue": "Journal of Chengdu Medical College",
        "year": 2006
    },
    "ve6BahQn": {
        "id": "ve6BahQn",
        "title": "Establishment and evaluation of IgG-and IgY-ELISA detection system for Cystatin C",
        "abstract": "Objective To establish double-antibodies sandwich ELISA detection system based on IgG and IgY antibodies against Cystatin C.Methods Hens and new-zealand rabbits were immunized with Cystatin C as antigen and the Cystatin C polyclonal antibodies IgY and IgG were purified separately.Three kinds of ELISA detection systems;I:capture antibody IgG+detection antibody IgY+enzyme labelled antibody against IgY;\u2161:capture antibody IgG+detection antibody IgY+enzyme labelled antibody F(ab')2 against IgY;\u2162:capture antibody IgY+detection antibody IgG+enzyme labelled antibody against IgG,were established.The sensitivity and specificity of these three kinds of sandwich assays were evaluated by the comparison of the Cystatin C minimum detection concentrations and the OD values of the negative controls.Results The Cystatin C minimum detection concentration of system I was 7.5 ng/mL(OD value of the negative control was 0.737).The Cystatin C minimum detection concentration of system \u2161 was 13 ng/mL(OD value of the negative control was 0.313).The Cystatin C minimum detection concentration of system \u2162 was 10 ng/mL(OD value of the negative control was 0.31).Conclusions Double-antibodies sandwich ELISA detection system based on IgG and IgY antibodies against Cystatin C was created successfully.System \u2161 and system \u2162 can be used for the detection of Cystatin C because of the better detection sensitivity and specificity than system I.",
        "keywords": [
            "IgG antibody",
            "Cystatin C",
            "ELISA",
            "IgY antibody"
        ],
        "authors": [
            {
                "name": "JIANG Hong-jiao",
                "org": "Department of biomedicine"
            },
            {
                "name": "LI Min-hui",
                "org": "Center of science and research,Chengdu Medical College,Chengdu ,China"
            },
            {
                "name": "Zou Qiang",
                "org": "Center of science and research,Chengdu Medical College,Chengdu ,China"
            },
            {
                "name": "WANG Qi",
                "org": "Department of biomedicine"
            },
            {
                "name": "WU Yong-qin",
                "org": "Department of biomedicine"
            },
            {
                "name": "WU Qi-hong",
                "org": "Department of biomedicine"
            },
            {
                "name": "DENG Wei",
                "org": "Department of biomedicine"
            },
            {
                "name": "LIU Wen-wen",
                "org": "Department of biomedicine"
            },
            {
                "name": "YANG Yan-ling",
                "org": "Department of biomedicine"
            },
            {
                "name": "DAI Shuang",
                "org": "Department of biomedicine"
            },
            {
                "name": "YANG Ping",
                "org": "Teaching-research office of biochemistry"
            }
        ],
        "venue": "Journal of Chengdu Medical College",
        "year": 2012
    },
    "WsGiZ4dr": {
        "id": "WsGiZ4dr",
        "title": "Comparison and optimization of staining methods for protein analysis in the Pythium sp.GY1938 strain of filamentous fungus",
        "abstract": "Objective To explore the best methods of staining in order to prepare a map of soluble proteins from the mycelium of the Pythium sp.GY1938 strain of mosquito-killing filamentous fungus.Methods Coomassie brilliant blue staining,Vorum silver staining,EMBL silver staining,and Blum silver staining were used to stain gels and map proteins separately after SDS-PAGE.Results Compared to the three methods of silver staining,Coomassie brilliant blue R-250 staining provided the most effective,simple,and quick staining of soluble proteins with a high molecular weight(HMW) or medium molecular weight(MMW)(\u226544 ku).Vorum silver staining was effective at staining soluble proteins with a low molecular weight(LMW)(<44 ku).Blum and EMBL silver staining were all not effective.Conclusion Both Coomassie brilliant blue R-250 and Vorum silver staining can be used to efficiently map the soluble proteins from the mycelium of the Pythium sp.GY1938 strain.The former is more suitable for mapping medium and high molecular weight proteins while the latter is more suitable for mapping low molecular weight proteins.",
        "keywords": [
            "Coomassie brilliant blue staining",
            "silver staining",
            "SDS-PAGE"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Department of Biochemistry,Chengdu Medical College,Chengdu ,China"
            },
            {
                "name": "ZHONG Jian",
                "org": "Department of Biomedicine,Chengdu Medical College"
            },
            {
                "name": "LEI Fan",
                "org": "Department of Biomedicine,Chengdu Medical College"
            },
            {
                "name": "YU Lin",
                "org": "Department of Biomedicine,Chengdu Medical College"
            },
            {
                "name": "YANG Si-si",
                "org": "Department of Biomedicine,Chengdu Medical College"
            },
            {
                "name": "LI Min-hui",
                "org": "Center of Science and Research,Chengdu Medical College"
            }
        ],
        "venue": "Journal of Pathogen Biology",
        "year": 2011
    },
    "mVUYpRjj": {
        "id": "mVUYpRjj",
        "title": "Monitoring survival of splenocytes and lysis percent of red blood cells by flow cytometry",
        "abstract": "Objective To development a technique of monitoring survival of splenocytes and lysis percent of red blood cells by flow cytometry.Methods Splenocytes were lysed by ACK or Tris-NH4Cl.The percentage of live lymphocytes and red cells in total splenocytes were detected by flow cytometry.Cell fusion assay was performed.Results The live lymphocytes and red cells could be classified by flow cytometry after dying by PI.If the 90 percent live lymphocytes were need to survivied,splenocytes were treated with Tris-NH4Cl for 10 min to remove the 82 percent red cells or with ACK for 0.5 or 1 min to remove the 90 percent red cells.Using these lymphocytes hybrided with SP2/0-Ag14,the 85 to 90 percent efficiencies of fusion could be detected.Conclusion The progression of lysing splenocyte could be monitorred by flow cytometry to ensure the survival lymphoctytes activity and clearance of red blood cells.",
        "keywords": [
            "cell fusion",
            "flow cytometry",
            "red blood cell lysis buffer"
        ],
        "authors": [
            {
                "name": "Li Minhui",
                "org": "Center of Science and Research"
            },
            {
                "name": "Liu Yang",
                "org": "Center of Science and Research"
            },
            {
                "name": "Yang Ping",
                "org": "Department of biochemistry,Chengdu Medical College,Chengdu,,China"
            },
            {
                "name": "Zheng Jing",
                "org": "Center of Science and Research"
            },
            {
                "name": "Yang Shuxia",
                "org": "Center of Science and Research"
            },
            {
                "name": "Yang Tai",
                "org": "Center of Science and Research"
            },
            {
                "name": "Zhang Lu",
                "org": "Center of Science and Research"
            },
            {
                "name": "Zou Qiang",
                "org": "Center of Science and Research"
            },
            {
                "name": "Li Hua",
                "org": "Cancer Center,Chengdu Military General Hospital,Chengdu,,China"
            }
        ],
        "venue": "International Journal of Laboratory Medicine",
        "year": 2012
    },
    "udN3FnB2": {
        "id": "udN3FnB2",
        "title": "An Observation on the Effect of Pythium sp.GY1938,A Newly Isolated Mosquito-killing Fungus,on Domestica Fly Larva(Musca domestica Vicina)",
        "abstract": "Objective: To test if the newly isolated mosquito-killing fungus(Pythium sp.,GY1938) is safe to domestica fly larvae(Musca domestica Vicina),a non-target organism other than mosquito.Methods: Fly eggs were randomly divided into 4 groups(200 for each).After they hatched,3 groups of them were fed with fodder mixed with different concentrations of fungal mycelia suspension and to be low-dosage group(0.1%),middle-dosage group(0.5%) and high-dosage group(1%)respectively.The other one group was fed with fodder without fungal mycelia as control.The mature larvae were checked morphologically and their body weight was measured with electronic balance.Results: There was no evidence to show that the fungus had any harmful effect on the development of the housefly eggs or larvae.Conclusion: Mosquito-killing fungus,Pythium sp.GY1938 is safe to domestica fly larvae.",
        "keywords": [
            "biological",
            "fungal safety",
            "houseflies",
            "pest control",
            "mosquito control"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Department of Biochemistry,Chengdu Medical College,Chengdu ,Sichuan,China"
            },
            {
                "name": "LIU Ping",
                "org": "Department of Biology,Guiyang Medical College,Guiyang ,China"
            },
            {
                "name": "SU Xiao-qing",
                "org": "Department of Biology,Guiyang Medical College,Guiyang ,China"
            },
            {
                "name": "WU Jian-wei",
                "org": "Department of Parasitology,Guiyang Medical College,Guiyang ,China"
            }
        ],
        "venue": "Journal of Guiyang Medical College",
        "year": 2006
    },
    "njZKedEu": {
        "id": "njZKedEu",
        "title": "Diffusing effect of DTT and 2-ME during SDS-PAGE electrophoresis",
        "abstract": "Objective: Dithiothreitol(DTT) and \u03b2-Mercaptoethanol(2-ME) are important reducing agents for SDS-PAGE.This study is to observe the diffusing effect of DTT and 2-ME during electrophoresis,and to find a way of avoiding this effect.Methods: We placed protein samples containing reducing agents and non-reduced protein samples separately in the sample wells at intervals for SDS-PAGE electrophoresis,and determined whether or not the electrophoretic lanes of the non-reduced samples were interfered by the adjacent lanes.Results: DTT and 2-ME diffused to the neighboring lane,so that the non-reduced samples were reduced partially.The spreading effect was positively correlated with the content of the reducing agent.Conclusion: DTT and 2-ME have a diffusing effect during SDS-PAGE electrophoresis.In separating the reduced and non-reduced proteins in the same gel at the same time,at least a blank lane should be set up in between them in order to avoid the diffusing effect.",
        "keywords": [
            "Reducing agent",
            "Diffusing effect",
            "Sodium dodecyl sulphate polyacrylamide gel electrophoresis"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Department of Biochemistry"
            },
            {
                "name": "LI Min-hui",
                "org": "Center for Scientific Research and Experiments"
            },
            {
                "name": "CHANG Shan",
                "org": "Department of Orthopedics,The First Affiliated Hospital"
            },
            {
                "name": "HE Jian-rong",
                "org": "Center for Scientific Research and Experiments"
            },
            {
                "name": "LUO Xing-yan",
                "org": "Center for Scientific Research and Experiments"
            },
            {
                "name": "LIU Yang",
                "org": "Center for Scientific Research and Experiments"
            },
            {
                "name": "ZOU Qiang",
                "org": "Department of Immunology,Chengdu Medical College,Chengdu ,Sichuan,China"
            }
        ],
        "venue": "Journal of Medical Postgraduates",
        "year": 2009
    },
    "nqHkKAay": {
        "id": "nqHkKAay",
        "title": "A rapid method for extraction of total protein from Pythium sp.GY1938 strain for proteomics research",
        "abstract": "To explore a rapid method to extract the mycelium total protein suitable for proteomics research from mosquito-killing filamentous fungus Pythium sp.GY1938 strain.Seven kinds of methods for breaking fungal mycelium cell walls and microscopic observations were performed to compare the breaking-wall efficiency and the differences of quantity of releasing proteins were analyzed with SDS-PAGE and coomassie brilliant blue staining.The results showed that grinding with silica sand and liquid nitrogen was the best rapid and effective method for extraction of total protein because this method appeared the most and the clearest bands.",
        "keywords": [
            "Preparation methods",
            "Proteomics.",
            "Total proteins",
            "Mosquito fungal Pythium sp.GY1938"
        ],
        "authors": [
            {
                "name": "YU Lin",
                "org": " *Department of Biomedicine,Chengdu Medical College,Chengdu ,China."
            },
            {
                "name": "HUANG Jie",
                "org": " *Department of Biomedicine,Chengdu Medical College,Chengdu ,China."
            },
            {
                "name": "FU Long-zhang",
                "org": " *Department of Biomedicine,Chengdu Medical College,Chengdu ,China."
            },
            {
                "name": "SONG Li-ping",
                "org": " *Department of Biomedicine,Chengdu Medical College,Chengdu ,China."
            },
            {
                "name": "LI Min-hui",
                "org": " *Department of Biomedicine,Chengdu Medical College,Chengdu ,China."
            },
            {
                "name": "YANG Ping",
                "org": " *Department of Biomedicine,Chengdu Medical College,Chengdu ,China."
            }
        ],
        "venue": "Journal of Medical Pest Control",
        "year": 2012
    },
    "VOpPHawL": {
        "id": "VOpPHawL",
        "title": "Comparison of the Effect for Filamentous Fungal Breaking-Wall by SDS-PAGE and Vorum Silver Staining",
        "abstract": "Objective: To compare the effects in the release of the intracellular protein in Pythium sp.GY1938 strain.Methods: Seven kinds of treatment including grinding with silica sand,sonication after grinding with silica sand,sonication with silica sand,sonication,grinding with liquid nitrogen,grinding with silica sand and liquid nitrogen,sonication after grinding with silica sand and liquid nitrogen were used in this research.Then,each lysate was treated with SDS-PAGE and the efficiency was evaluated by Vorum silver staining.Results: The silver staining results showed that the sixth method,grinding with silica sand and liquid nitrogen,was the optimum mean to break cell wall of this fungi because of the high integrality and separation efficiency of protein extraction.Conclusion: The method grinding with silica sand and liquid nitrogen was the first selective intracellular protein extraction means in Pythium sp.GY1938 strain for the further fungal proteomic research.",
        "keywords": [
            "Pythium sp.GY1938",
            "breaking-wall",
            "filamentous fungi",
            "silver staining"
        ],
        "authors": [
            {
                "name": "LI Min-Hui",
                "org": "Center of Science and Research"
            },
            {
                "name": "PAN Ke-Jian",
                "org": "Department of Biomedicine"
            },
            {
                "name": "SONG Li-Ping",
                "org": "Department of Biomedicine"
            },
            {
                "name": "ZHONG Wen-Ying",
                "org": "Department of Biomedicine"
            },
            {
                "name": "ZOU Ke-Ke",
                "org": "Department of Biomedicine"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Biochemistry"
            }
        ],
        "venue": "Letters in Biotechnology",
        "year": 2011
    },
    "TcOqqqyc": {
        "id": "TcOqqqyc",
        "title": "Meta-analysis of TGF-\u03b21-509C/T gene polymorphisms and colorectal cancer",
        "abstract": "Objective In the recent years,more and more attention is being paid to the relationship between transforming growth factor beta 1-509C/T(TGF-\u03b21-509C/T) gene polymorphisms and the susceptibility to colorectal cancer(CRC).Heterogeneity in genetics and phenotypes lead to different results in different studies.This study aims to investigate the relationship of TGF-\u03b21-509C/T gene polymorphisms with the susceptibility to CRC.Methods Published literature addressing the relationship of TGF-\u03b21-509C/T gene polymorphisms with the susceptibility to CRC was identified by searching PubMed,CNKI and VIP,and RevMan 5.0 was used for examining the heterogeneity across the studies and calculating the pooled OR,followed by analyses of the sensitivity and evaluation of the publication bias.Results This Meta-analysis included 2314 cases and 4247 controls from 10 published case-control studies.Significant heterogeneities were found in the genotypes among the studies except for TC versus TT,so a random effect model was used for data synthesis,which showed no significant associations among the genotypes.However,in the population subgroup analysis,significantly decreased risks of CRC were found for(TC+CC) versus TT(OR = 0.83;95% CI: 0.7-0.99;P=0.04) among Asians,with obvious heterogeneity(P=0.08>0.05),and therefore the fixed effect model could be used for analysis.There was no publication bias but sensitivity lacked stability.Conclusion TGF-\u03b21-509TT gene polymorphisms may be protective factors against CRC among Asians.",
        "keywords": [
            "Meta-analysis",
            "Colorectal cancer",
            "TGF-\u03b21",
            "Genetic polymorphisms"
        ],
        "authors": [
            {
                "name": "LI Min-hui",
                "org": "Scientific Research Center,2.Department of Immunology,3.Department of Biochemistry and Molecular Biology,Chengdu Medical College,Chengdu ,Sichuan,China"
            },
            {
                "name": "YUAN Jie",
                "org": "Scientific Research Center,2.Department of Immunology,3.Department of Biochemistry and Molecular Biology,Chengdu Medical College,Chengdu ,Sichuan,China"
            },
            {
                "name": "LI Hua",
                "org": "Department of Oncology,Chengdu Military General Hospital,Chengdu ,Sichuan,China"
            },
            {
                "name": "ZOU Qiang",
                "org": ""
            },
            {
                "name": "LIU Yang",
                "org": "Scientific Research Center,2.Department of Immunology,3.Department of Biochemistry and Molecular Biology,Chengdu Medical College,Chengdu ,Sichuan,China"
            },
            {
                "name": "YANG Ping",
                "org": ""
            }
        ],
        "venue": "Journal of Medical Postgraduates",
        "year": 2011
    },
    "Zq6ZHYlV": {
        "id": "Zq6ZHYlV",
        "title": "Comparative analysis and bias evaluation of the testing results of BUN,Cr,GLU and UA among three different biochemical analysis systems",
        "abstract": "Objective:To explore and evaluate the comparability and bias of the testing results of blood urea nitrogen(BUN),creatinine(Cr),glucose(GLU)and uric acid(UA)derived from three different biochemical analysis systems in three hospitals and to validate whether mutual accredit of these testing results can be performed among these hospitals.Methods:According to the document of NCCLS EP9-A,5-7 clinic samples were detected in three kinds of different biochemical analysis systems(Beckman CX4,Olympus 2700 and Hitachi 7600)respectively everyday.The testing results of total 41 samples were recorded within 7 days and those of 40 samples were kept after one outlier value was deleted.The testing results derived from three biochemical analysis systems were analyzed comparatively and their bias was evaluated by biochemical analysis in Beckman CX4 as a control method and biochemical analyses in Olympus 2700 and Hitachi 7600 as experimental methods.Results:Both correlation(r2>0.95)and linear regression between the testing results of BUN,Cr,GLU and UA in three different biochemical analysis systems in three hospitals were good.Their anticipated biases(but with exception for Cr when its testing result was within the normal reference range)were within allowed biases.Conclusions:On the basis of good internal quality control and external quality assessment,the testing results of BUN,Cr,GLU and UA derived from three different biochemical analysis systems from the three hospitals can be mutually accredited.",
        "keywords": [
            "blood chemical analysis",
            "UA",
            "Glu",
            "Cr",
            "biochemical analysis systems",
            "BUN"
        ],
        "authors": [
            {
                "name": "KANG Shu-xia",
                "org": "Department of Clinical Laboratories,The First People's Hospital of Bengbu,Bengbu "
            },
            {
                "name": "YANG Ping",
                "org": "Department of Clinical Laboratories,The First Affiliated Hospital of Bengbu Medical College,Bengbu "
            },
            {
                "name": "LIU Gang",
                "org": "Department of Clinical Laboratories,The Third People's Hospital of Bengbu,Bengbu ,China"
            },
            {
                "name": "HU En-bi",
                "org": "Department of Clinical Laboratories,The Third People's Hospital of Bengbu,Bengbu ,China"
            },
            {
                "name": "ZHANG Fan",
                "org": "Department of Clinical Laboratories,The First Affiliated Hospital of Bengbu Medical College,Bengbu "
            },
            {
                "name": "HENG Er-hu",
                "org": "Department of Clinical Laboratories,The First People's Hospital of Bengbu,Bengbu "
            }
        ],
        "venue": "Journal of Bengbu Medical College",
        "year": 2007
    },
    "wrbuVVgp": {
        "id": "wrbuVVgp",
        "title": "The Distribution and Drug Resistance of Pathogenic Bacteria L in Urinary Infection",
        "abstract": "Objective To investigate the distribution and drug resistance of pathogenic bacteria L in urinary infection,and to provide the basis for clinical rational choose of antimicrobial agents.Methods Bacteria culture and drug susceptibility test with K-B method were performed among 188 samples from urinary tract bacteria L infection patients.Results Urinary tract infection with bacteria L was primarily negative bacillus,followed by Gram positive coccus,fungi.Among them,Escherichia coli accounted 37.77%,accounting for 63.39% of gram-negative bacilli;Enterococcus genus accounted for 16.49%,staphylococcus genus accounted for 9.57%,candida genus 8.51%.Antimicrobial susceptibility test showed: urinary tract infection of various pathogenic bacteria L antimicrobial produced different degree of resistance,but gram-positive cocci to vancomycin,most gram-negative bacilli imipenem sensitive to rate of 100.0%,acinetobacter baumannii,crayresearch influenzae to imipenem assumed different degree resistance;produce super broad-spectrum beta-lactamase(ESBLs) escherichia coli detection rate was 28.17%.Conclusion Urinary tract infection with conditions pathogenic bacteria L main and resistant pathogens were relatively serious,effective measures should be taken to control the popular trend of antibiotic resistant bacteria.",
        "keywords": [
            "Resistance",
            "Bacteria L",
            "Urinary tract infections"
        ],
        "authors": [
            {
                "name": "WU Xue-ping",
                "org": ".Department of Nephrology,the First Affiliated Hospital of Bengbu Medical College,Bengbu ,Anhui,China"
            },
            {
                "name": "WANG Jing",
                "org": ".Department of Nephrology,the First Affiliated Hospital of Bengbu Medical College,Bengbu ,Anhui,China"
            },
            {
                "name": "YANG Ping",
                "org": ".Department of Nephrology,the First Affiliated Hospital of Bengbu Medical College,Bengbu ,Anhui,China"
            }
        ],
        "venue": "Chinese Journal of General Practice",
        "year": 2011
    },
    "wsrdfAVK": {
        "id": "wsrdfAVK",
        "title": "Comparison of two methods of platelet counting by XE-2100 automatic hematology analyzer",
        "abstract": "Objective:To observe the accuracy of optical(PLT-O) method and electric impedance(PLT-I) method in counting the platelet by the XE-2100 automatic hematology analyzer.Methods:The platelet samples were collected from the high-value group(40 cases)(PLT>300\u00d7109/L),median-value group(40 cases)(80\u00d7109/L<PLT\u2264300\u00d7109/L) and low-value group(40 cases)(PLT\u226480\u00d7109/L).The platelet counting was conducted using PLT-O method and PLT-I method with the XE-2100 automatic hematology analyzer,and the results were compared with those by manual method.Results:The results obtained by PLT-O and PLT-I methods were consistent with those by manual method in the median-value group and the high-value platelet group(P>0.05).However,of those low-value groups,the results of PLT-O are more consistent with the results of manual method than the one of PLT-I.Conclusions:The counting results by PLT-O and PLT-I methods using the XE-2100 hematology analyzer are consistent in the median-value and the high-value platelet groups,but results by PLT-O have more important reference value in the re-examination to low-value platelet group.",
        "keywords": [
            "XE-2100 automatic hematology analyzer",
            "optical method",
            "electric impedance method",
            "latelet"
        ],
        "authors": [
            {
                "name": "GUO Hui",
                "org": "Department of Clinical Laboratory,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "GUO Pu",
                "org": "Department of Clinical Laboratory,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "ZHONG Zheng-rong",
                "org": "Department of Clinical Laboratory,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "ZHENG Zhao-jun",
                "org": "Department of Clinical Laboratory,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Clinical Laboratory,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "ZHENG Jing",
                "org": "Department of Clinical Laboratory,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            }
        ],
        "venue": "Journal of Bengbu Medical College",
        "year": 2011
    },
    "FoN4U5FY": {
        "id": "FoN4U5FY",
        "title": "Protective effect of leflunomide to renal tissues in diabetic rats",
        "abstract": "Objective To investigate the renal protective effects of leflunomide in diabetic rats and to explore its mechanism. Method Sprague-Dawlay(SD)rats were divided into control rats, diabetic rats and diabetic rats treated with leflunomide. After 12 weeks, 24 hours urine protein, blood glucose, serum creatinine, blood urea nitrogen and creatinine clearance rate were detected. The kidney hypertrohy index was measured, partial nephridial tissue were treated pathology observed. Inmmunohistochemistry was used to analyse the expression of MCP-1 and CD68. Results compared with the untreated diabetic group, urinary albumin excretion and creatinine clearance rate of leflunomied treated rats were substantially decreased. The expression of MCP-1 and CD68 in leflunomide group were much lower than diabetic untreated group. Leflunomide also improved the histological changes of diabetic rats. Conclusions Leflunomide has some renal protective effect on diabetic rats, partly through down-regulating MCP-1 expression and reducing monocyte / macrophage infitration.",
        "keywords": [
            "CD68",
            "Leflunomide",
            "Monocyte chemoattractant protein-1",
            "Diabetic nephropathy"
        ],
        "authors": [
            {
                "name": "CHEN Wei-dong",
                "org": ". Department of Nephrology, the First Affiliated Hospital of Bengbu Medical College, Bengbu , China"
            },
            {
                "name": "CHANG Bao-chao",
                "org": ". Department of Nephrology, the First Affiliated Hospital of Bengbu Medical College, Bengbu , China"
            },
            {
                "name": "YANG Ping",
                "org": ". Department of Nephrology, the First Affiliated Hospital of Bengbu Medical College, Bengbu , China"
            },
            {
                "name": "ZHANG Yan",
                "org": ". Department of Nephrology, the First Affiliated Hospital of Bengbu Medical College, Bengbu , China"
            },
            {
                "name": "LIU Lei",
                "org": ". Department of Nephrology, the First Affiliated Hospital of Bengbu Medical College, Bengbu , China"
            }
        ],
        "venue": "The Journal of Practical Medicine",
        "year": 2009
    },
    "eIt4iSqm": {
        "id": "eIt4iSqm",
        "title": "Applied Value of Random Quantitative Test of Urine Protein on Proteinuria",
        "abstract": "Objective To investigate the applied value of random quantitative test of urine protein on proteinuria.Methods The 24-hour urinary protein excretion were determined,while the spot urine protein and creatinine,morning void urine protein and creatinine were tested,and the urine protein-to-creatinine ratio(Upr/Ucr) was calculated.The serum creatinine(Scr) in the venous blood was detected simultaneously.Results The correlation coefficients of 24-Upr with spot urine and morning void urine Upr/Ucr were 0.851 and 0.853 respectively(P<0.01).Conclusion The spot urine and morning void urine Upr/Ucr can replace 24 h Upr in the disposable urinary protein determination as a good indicator to predict the urine protein excretion.",
        "keywords": [
            "Urine protein",
            "Creatinine",
            "Urine protein/creatinine ratio"
        ],
        "authors": [
            {
                "name": "CHEN Qing-shu",
                "org": ",et al.Department of Clinical Laboratory,the First Affiliated Hospital of Bengbu Medical College,Bengbu ,Anhui,China"
            },
            {
                "name": "YANG Ping",
                "org": ",et al.Department of Clinical Laboratory,the First Affiliated Hospital of Bengbu Medical College,Bengbu ,Anhui,China"
            },
            {
                "name": "ZHANG Lun-jun",
                "org": ",et al.Department of Clinical Laboratory,the First Affiliated Hospital of Bengbu Medical College,Bengbu ,Anhui,China"
            }
        ],
        "venue": "Chinese Journal of General Practice",
        "year": 2009
    },
    "u63XKcnh": {
        "id": "u63XKcnh",
        "title": "A study on the resolution of sampling probe towing positive in automatic enzyme immunoassay instrument",
        "abstract": "Objective:To investigate the resolution of sampling probe towing positive in automatic enzyme immunoassay instrument.Methods:Anti-human immunodeficiency virus(HIV),anti-treponema pallidum(TP),anti-hepatitis C virus(HCV) or hepatitis B surface antigen(HBsAg) strong positive specimens were collected from routine screening test.The towing positive simulation test was performed in RMP 200 automatic enzyme immunoassay under use of demineralized water or 0.1% Tween-20 weak alkaline solution for sampling probe irrigation solutions conditions.By comparison of the two groups results,it was observed that 0.1% Tween-20 weak alkaline solution in role of avoid sampling probe towing positive and it effect on ELISA.Results:It was found that every of anti-HIV,anti-TP,anti-HCV,and HBsAg sepecimen had experienced towing positive under use of demineralized water for sampling probe irrigation solutions.Among them,anti-HIV towing positive was most obvious and had 6 towing positive holes;while HBsAg appeared only a towing weak positive hole.In contrast to demineralized water,all towing positive phenomena of anti-HIV,anti-TP,anti-HCV and HBsAg strong positive specimens were avoided under use of 0.1% Tween-20 weak alkaline solution for sampling probe irrigation solutions.Moreover,the results of quality control serum,positive and negative control under two different irrigation solutions had no significant difference for the same test item(P>0.05).Conclusions:The use of 0.1% Tween-20 weak alkaline solution for sampling probe irrigation solutions could avoid appearance of sampling probe towing positive in automatic enzyme immunoassay instrument and it had no significant effect on ELISA.",
        "keywords": [
            "towing positive",
            "sampling probe",
            "autoanalysis",
            "Tween-20",
            "immunoenzyme technique"
        ],
        "authors": [
            {
                "name": "ZHU An-you",
                "org": "Department of Clinical Laboratories,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "WANG Feng-chao",
                "org": "Department of Clinical Laboratories,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Clinical Laboratories,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "GE Xin",
                "org": "Department of Clinical Laboratories,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "GUO Hui",
                "org": "Department of Clinical Laboratories,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "LIU Ya",
                "org": "Department of Clinical Laboratories,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            }
        ],
        "venue": "Journal of Bengbu Medical College",
        "year": 2010
    },
    "5ZucMoFL": {
        "id": "5ZucMoFL",
        "title": "Effect of Astragalus on Expression of Urotensin \u2161 in Renal Tissues of Rats with Diabetic Nephropathy",
        "abstract": "Objective To investigate the effect of Astragalus on the expression of urotensin \u2161 in renal tissues of rats with diabetic nephropathy.Methods Rat model with diabetic nephropathy was established by high-carbonhydrate and high fat diet and intraperitoneal injection of streptozotocin(STZ).The rats were randomly divided into 3 groups that is normal control group(NC,n=10),diabetic nephropathy group(DN,n=10),Astragalus treated group(HZ,n=10)(fed to the Astragalus 5 ml/kg).Animals were sacrificed at 14 weekends and under experiment: Determination of glucose,cholesterol,triglyceride,high-density lipoprotein cholesterol(HDL-C),low density lipoprotein,serum creatinine,blood urea nitrogen and urinary albumin quantitative(24 h).immunohistochemical techniques U\u2161detection protein expression,RT-PCR technology detection U\u2161 mRNA expressions.Results Compared with NC group,each model group tentative KI,BG,TC,TG,Scr,BUN,24 h UTP increased significantly,HDL reduced significantly,and difference was statistically significant(P<0.01).The above indexes HZ group compared with the DN decreased obviously,there is a statistically significant difference(P<0.05).Compared with NC group the expression of U\u2161and U\u2161mRNA were increased significantly in renal tissues of DN group(P<0.01).However,the expression of U\u2161and U\u2161 mRNA in HZ group were significantly decreased in comparison with DN group(P<0.05).Conclusion Astragalus can be used to treat diabetic nephropathy and the mechanism may be related to down-regulating the expression of U\u2161protein and U\u2161 mRNA.",
        "keywords": [
            "Urotensin \u2161",
            "Type 2 diabetes",
            "Astragalus",
            "Diabetic nephropathy"
        ],
        "authors": [
            {
                "name": "DING Zhi-zhen",
                "org": ",et al.Department of Renal Medicine,the First Affiliated Hospital of Bengbu Medical College,Bengbu ,Anhui,China"
            },
            {
                "name": "CHEN Wei-dong",
                "org": ",et al.Department of Renal Medicine,the First Affiliated Hospital of Bengbu Medical College,Bengbu ,Anhui,China"
            },
            {
                "name": "YANG Ping",
                "org": ",et al.Department of Renal Medicine,the First Affiliated Hospital of Bengbu Medical College,Bengbu ,Anhui,China"
            }
        ],
        "venue": "Chinese Journal of General Practice",
        "year": 2011
    },
    "kRnQ3pdZ": {
        "id": "kRnQ3pdZ",
        "title": "Comparison of dialysis adequacy and inflammation in hemodialysis patients with different vascular access",
        "abstract": "Objective:To find out the favorable vascular access for dialysis patients through comparing the dialysis adequacy and malnutrition-inflammation between different procedures.Methods: Fifty-five renal patients undergone long-term access for hemodialysis between Jan.2009 and Jan.2010 were enrolled in and examined in a follow-up period of 9 to 12 months for comparing the Kt/V values by using vascular access of arteriovenous fistulae(AVF) or cuffed and tunneled catheter(CTC) in an internal jugular vein,concentrations of C-reaction protein(CRP),albumin(ALB),prealbumin(PA)and hemoglobin(HGB),and complications associated with vascular access.Results: Of the 55 hemodialysis patients,40 underwent native AVF and 15,CTC as the long-term vascular access for hemodialysis.Although Kt/V values were greater than 1.2 for the two groups of patients,yet,the outcomes in AVF group were superior to that of CTC group(P<0.01).Still,the patients in AVF group had lower CRP level but higher ALB,HGB as compared with CTC group(P<0.01).Conclusion: Vascular access either with AVF or CTC will lead to the similar outcomes,nevertheless,the former has fewer complications and lower incidence of nutrition/inflammation,and is preferably for clinical recommendation.",
        "keywords": [
            "inflammation",
            "vascular access",
            "dialysis adequacy"
        ],
        "authors": [
            {
                "name": "LIU Lei",
                "org": " Department of Nephrology,Affiliated No.1 Hospital,Bengbu Medical College,Bengbu ,China"
            },
            {
                "name": "CHANG Bao-chao",
                "org": " Department of Nephrology,Affiliated No.1 Hospital,Bengbu Medical College,Bengbu ,China"
            },
            {
                "name": "YANG Ping",
                "org": " Department of Nephrology,Affiliated No.1 Hospital,Bengbu Medical College,Bengbu ,China"
            },
            {
                "name": "ZHANG Yan",
                "org": " Department of Nephrology,Affiliated No.1 Hospital,Bengbu Medical College,Bengbu ,China"
            },
            {
                "name": "CHEN Wei-dong",
                "org": " Department of Nephrology,Affiliated No.1 Hospital,Bengbu Medical College,Bengbu ,China"
            }
        ],
        "venue": "Acta Academiae Medicinae Wannan",
        "year": 2012
    },
    "jkJOQYbX": {
        "id": "jkJOQYbX",
        "title": "The clinical diagnostic effect of L-form bacterium culture in urine samples from patients with urinary infection",
        "abstract": "Objective:To evaluate the clinical effect of L-form bacterium culture in urine samples from patients with urinary infection.Methods:Five hundred and ten urine specimens were examined with the routine and L-form bacterium culture,the isolated strains were tested with drug susceptibility test.Results:Two hundred and thirty out of 510 urine specimens were identified as bacterial growth.Of them,100 wild-type strains and 60 L-form strains alone were isolated,and both the wild-type and the L-form strains from 70 urine samples.The drug susceptibility test were displayed that all of the L-form strains were susceptible to macrolides and tetracycline antibiotics,while the wild-type to penicllium and cephem antibiotics.Conclusions:Most of the urinary infection may be attributed to L-form bacterium.Therefore,the L-form bacterium culture should be done as a routine test and it contributes to the clinical diagnosis and rational use of antibiotics.",
        "keywords": [
            "L-form",
            "bacterium culture",
            "urinary tract infection",
            "bacterium"
        ],
        "authors": [
            {
                "name": "ZHENG Jing",
                "org": "Department of Clinical Laboratory,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "ZHENG Zhao-jun",
                "org": "Department of Clinical Laboratory,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Clinical Laboratory,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "ZHANG Fan",
                "org": "Department of Clinical Laboratory,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "GUO Pu",
                "org": "Department of Clinical Laboratory,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "GUO Hui",
                "org": "Department of Clinical Laboratory,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "SUN Hong",
                "org": "Department of Clinical Laboratory,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "LI Xing-wu",
                "org": "Department of Clinical Laboratory,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            }
        ],
        "venue": "Journal of Bengbu Medical College",
        "year": 2011
    },
    "LokmdrAY": {
        "id": "LokmdrAY",
        "title": "Application of plasma cystatin C in assessing glomerular filtration rate",
        "abstract": "Objective:To explore the value of cystatin C in assessing glomerular filtration rate. Methods:One hundred and nine patients were devided into 4 groups according to the level of endogenous creatinine clearance rate(Ccr),which included normal renal function group(Ccr\u226580 ml/min,n=33),renal insufficiency compensation group(50 ml/min\u2264Ccr<80 ml/min,n=20),renal insufficiency decompensation group(20 ml/min\u2264Ccr<50 ml/min,n=27) and renal failure group(Ccr<20 ml/min,n=29).Sixty-nine healthy people were set as control group.The levels of cystatin C,Scr and urea nitrogen in blood plasma of all group were determined,which were statistically analyzed. Results:Compared with control group,there were significant differences in the cystatin C levels of other groups(P<0.01).The levels of Cystatin C increased along with the Ccr levels decline.There were good relevant relationships between Ccr and Scr(P<0.01). Conclusions:Blood plasma cystatin C is a sensitive indicator for evaluating the glomerular filtration function,which can replace the role of Ccr.",
        "keywords": [
            "endogenous creatinine clearance rate",
            "glomerular filtration rate",
            "cystatin C",
            "renal failure"
        ],
        "authors": [
            {
                "name": "DENG Rong",
                "org": "Department of Laboratory,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Laboratory,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "ZHENG Jing",
                "org": "Department of Laboratory,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "ZHENG Zhao-jun",
                "org": "Department of Laboratory,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            }
        ],
        "venue": "Journal of Bengbu Medical College",
        "year": 2012
    },
    "qbAKCkk4": {
        "id": "qbAKCkk4",
        "title": "Comparison of the results of some routine biochemical tests by the dry and the liquid chemical methods",
        "abstract": "Objective:To compare the test results by the dry and the liquid biochemical analyzers.Methods:Forty-four blood samples without hemolysis and hyperlipidemia were analyzed of the alanine aminotransferase(ALT),aspartate aminotransferase(AST),total protein(TP),albumin(ALB),total bilirubin(TB),uric acid(UA),blood urea nitrogen(BUN) and serum creatinine(Scr) in SPOTCHEM~(TM)\u2161 SP-4430 and in OLYMPUS AU2700 chemical analyzer.Results:The test results of BUN,TB,TP were statistically different by the two methods(P<0.05 to P<0.001),but the difference was not significant in those of ALT,AST,ALB,UA and Scr(P>0.05).Conclusions:There are great differences in some of the test results by the dry and the liquid chemical methods.And it is essential to analyze the results by the two methods and calibrate the chemical analyzers so as to assure their accuracy.",
        "keywords": [
            "biochemistry test",
            "liquid chemical method",
            "dry chemical method"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Department of Clinical Laboratories,Affiliated Hospital of Bengbu Medical College,Bengbu ,China"
            }
        ],
        "venue": "Journal of Bengbu Medical College",
        "year": 2006
    },
    "fzYheAqN": {
        "id": "fzYheAqN",
        "title": "The Clinical Observation the Treatment of Refractory Nephrotic Syndrome with Leflunomide",
        "abstract": "Objective To investigate the safety and clinical efficacy of leflunomide and prednisone in the treatment of refractory nephrotic syndrome.Methods 60 patients in our hospital from January 2007 to December 2010 with refractory nephrotic syndrome were selected,40 patients were treated with leflunomide and prednisone,and 20 patients in the control group were treated with Tripterygium glycosides and prednisone.Patients were observed before and 4 weeks,8 weeks,24 weeks after treatment.24-hour urinary protein,blood,liver and kidney function were assayed and the rate of adverse reactions during treatment was recorded.Results The increase of serum albumin and decrease of urinary protein were significant in Leflunomide and prednisone treatment group(P<0.05),with higher remission rate(P<0.005) and the lower incidence of adverse reactions.Little effect on reproductive function occurred in these patients,most patients could tolerate the treatment.Conclusion Leflunomide and prednisone treatment can relieve refractory nephrotic syndrome,the clinical remission rate may be higher than Tripterygium glycosides and prednisone therapy,the long-term efficacy remained to be investigated.",
        "keywords": [
            "Leflunomide",
            "RNS"
        ],
        "authors": [
            {
                "name": "WANG Jing",
                "org": ",et al.Department of Nephrology,the First Affiliated Hospital of Bengbu Medical College,Bengbu ,Anhui,China"
            },
            {
                "name": "CHANG Bao-chao",
                "org": ",et al.Department of Nephrology,the First Affiliated Hospital of Bengbu Medical College,Bengbu ,Anhui,China"
            },
            {
                "name": "YANG Ping",
                "org": ",et al.Department of Nephrology,the First Affiliated Hospital of Bengbu Medical College,Bengbu ,Anhui,China"
            }
        ],
        "venue": "Chinese Journal of General Practice",
        "year": 2011
    },
    "yc9YKyTh": {
        "id": "yc9YKyTh",
        "title": "Clinical analysis of the pathogenicity of bacteria L-form in recurrent urinary tract infection",
        "abstract": "Objective To explore the clinical peculiarity and the pathogenicity of bacteria L-form in recurrent urinary tract infection,and provide scientific evidences for clinical diagnosis and treatment.Method 127 cases of recurrent pyelonephritis diagnosed by bacterial culture were divided,according to pathogens,into general bacteria group,accompanied bacteria L-form group and bacteria L-form group respectively,with the healthy individuals as the control group. The levels of urinary N-acetyl-beta-D-glocosamidase(NAG) by NAG/urinary creatinine (UCr) and retinoid-binding protein (RBP) were detected.Result The levels of urinary NAG/UCr and RBP in three observed groups were higher than those in healthy control group(P<0.01); There were no significant differences between the general bacteria,accompanied bacteria L-form and bacteria L-form groups (P>0.05). Conclusion Bacteria L-form (including accompanied L-from bacteria) are the main pathogens in recurrent urinary tract infection. Clinical research demonstrated that bacteria L-form have pathogenicity and play an important in recurrent urinary tract infection.",
        "keywords": [
            "Urinary tract infection",
            "Pathogenicity",
            "Bacteria L-form"
        ],
        "authors": [
            {
                "name": "CHEN Wei-dong",
                "org": "Department of Nephrology"
            },
            {
                "name": "CHANG Bao-chao",
                "org": "Department of Detection,the First Affiliated Hospital of Bengbu Medical College,Anhui ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Detection,the First Affiliated Hospital of Bengbu Medical College,Anhui ,China"
            },
            {
                "name": "ZHANG Yan",
                "org": "Department of Nephrology"
            },
            {
                "name": "LIU Lei",
                "org": "Department of Nephrology"
            }
        ],
        "venue": "Chinese Journal of Microecology",
        "year": 2010
    },
    "XXrpLXYt": {
        "id": "XXrpLXYt",
        "title": "Changes and significance of biochemical markers of myocardial damage in the perioperation of heart valve prosthesis replacement",
        "abstract": "Objective:To investigate the changes and the clinical value of biochemical markers of myocardial damage in patients undergoing operation of heart valve replacement.Methods:The creatine kinase(CK),creatine kinase-MB(CK-MB),cardiac treponin I(cTnI),C reactive protein(CRP),lactate dehydrogenase(LDH)and hydroxybutyrate dehydrogenase(HBDH)in 40 patients receiving heart valve replacement were measured before operation,instantly after extracorporeal circulation,and at 6,24,48,72 hour and 6 days after the operation,and the changes were analyzed.Results:All the biochemical markers of myocardial damage were within normal limits except CRP before operation.The figures of cTnI and CK-MB increased significantly at 6 hour after operation(P<0.01).Aspartate aminotrans ferase(AST),LDH and HBDH rose significantly at 24 hour after operation.CRP reached the peak at 48 hour after operation.The two variables of cTnI and CK-MB in serum showed a positive linear correlation and had a higher correlativity comparable to other markers.Conclusions:All the biochemical markers of myocardial damage present abnormal changes successively during the perioperation of cardiac valve replacement.Monitoring the myocardial biochemical markers can decrease sudden death and incidence of other cardiac events.",
        "keywords": [
            "biochemical markers",
            "blood chemical analysis",
            "cardiac valve replacement",
            "myocardial damage",
            "heart valve diseases/surgery"
        ],
        "authors": [
            {
                "name": "ZHANG Fan",
                "org": "Department of Clinical Laboratories,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "LIU Yu-xia",
                "org": "Department of Clinical Laboratories,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "CHEN Jian-wen",
                "org": "Department of Clinical Laboratories,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "CHENG Pei-ping",
                "org": "Department of Clinical Laboratories,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Clinical Laboratories,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "ZHANG Lun-Jun",
                "org": "Department of Clinical Laboratories,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            },
            {
                "name": "DENG Rong",
                "org": "Department of Clinical Laboratories,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui ,China"
            }
        ],
        "venue": "Journal of Bengbu Medical College",
        "year": 2009
    },
    "cTMfQXle": {
        "id": "cTMfQXle",
        "title": "Study on Microbial Degradation to Pesticide Residues in Soil",
        "abstract": "In order to study the degradation of microbial agents to pesticide residues in soil,a series of experiments had been carried out in laboratory and field.The results showed that EM bacteria and Bacillus subtilis had obvious degradation to phoxim and profenofos in the hydrolysis experiment.Bacillus subtilis had also strong biodegradability to methyl parathion in the soil.A preliminary study was done yet on the amount of the Bacillus subtilis agent to the pesticide residues in soil.",
        "keywords": [
            "Bacillus subtilis",
            "Degradation",
            "Pesticide residue in soil",
            "EM bicteria",
            "Microbial agent"
        ],
        "authors": [
            {
                "name": "WANG Lian-xiang",
                "org": "Heze Academy of Agricultural Sciences,Heze ,China"
            },
            {
                "name": "YAN Shen",
                "org": "College of Life Science,Anhui Agricultural University, Hefei ,China"
            },
            {
                "name": "YUAN Fang-yao",
                "org": "Shandong Institute of Agricultural Sustainable Development,Jinan ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Shandong Institute of Agricultural Sustainable Development,Jinan ,China"
            },
            {
                "name": "ZHANG Wei-zhan",
                "org": "Shandong Institute of Agricultural Sustainable Development,Jinan ,China"
            }
        ],
        "venue": "Shandong Agricultural Sciences",
        "year": 2010
    },
    "KWoC8twR": {
        "id": "KWoC8twR",
        "title": "Regional Supply Capacity of Agricultural Products in Shandong Province Based on GIS",
        "abstract": "The authors select six indices of resource endowment, supply scale and structure of agricultural products in assessment area of China, and then use Factor Analysis Method and Geographic Information System (GIS) technology to classify the supply capacity of agricultural products in 140 counties and cities of Shandong Province. The authors also made a comprehensive quantitative and locational evaluation. Based on this, the authors put forward some suggestions on how to improve the supply capacity of agricultural products in Shandong Province of China.",
        "keywords": [
            "agricultural production",
            "geographic information system",
            "food safety",
            "market research",
            "gis",
            "marketing",
            "factor analysis"
        ],
        "authors": [
            {
                "name": "YANG Li-ping",
                "org": "Shandong Institute of Agriculture Sustainable Development,Jinan 250100,China"
            },
            {
                "name": "GUO Hong-hai",
                "org": " Shandong Institute of Agriculture Sustainable Development,Jinan ,China"
            },
            {
                "name": "YAO Hui-min",
                "org": " Shandong Institute of Agriculture Sustainable Development,Jinan ,China"
            },
            {
                "name": "SUN Xiao-qing",
                "org": " Shandong Institute of Agriculture Sustainable Development,Jinan ,China"
            },
            {
                "name": "ping yang",
                "org": " Shandong Institute of Agriculture Sustainable Development,Jinan ,China"
            },
            {
                "name": "yong wang",
                "org": " Shandong Institute of Agriculture Sustainable Development,Jinan ,China"
            },
            {
                "name": "ZHANG Wei-zhan",
                "org": " Shandong Institute of Agriculture Sustainable Development,Jinan ,China"
            }
        ],
        "venue": "\u4e9a\u6d32\u519c\u4e1a\u7814\u7a76(\u82f1\u6587\u7248)",
        "year": 2009
    },
    "peTVPOQR": {
        "id": "peTVPOQR",
        "title": "Study on Characteristics of Production and Quality of Peanut in Middle and Lower Reaches of Yangtze River",
        "abstract": "In order to guide and deepen the regional division of peanut production in the middle and lower reaches of Yangtze River, use of agricultural resources reasonably and efficiently and provide the theoretical basis forimproving the quality of peanut products, the characteristics of production and quality of peanut in the middle and lower reaches of Yangtze Riverwere studied based on GIS technology and the methods of mathematical statistics.The result showed that the planting scale and yield of the peanut in the region plays an important role in the country, and in this region the difference of production levels was significant, the unit yield was lower, yield potential was higher and the favorable weather conditions were conducive to ensuring the quality of peanut in harvesting and drying; Influenced by ecological conditions, the Spanish type peanut was mainly planted in the region, its qualities were high protein content in consumption and medium fat content in oil, furthermore the O/L of it was relatively high which makes forincreasing the stability of peanut products; In the spatial distribution, the protein content of the peanut was higher from northwest to southeast and it's the same from the northeast to southwest and the fat content of the peanut was lower from the north to south and it's the same from the west to east, the O/L of the peanut in the high sand areas along the river and south hilly areas of the Yangtze was significantly higher than it in the south areas of the Yangtze.The climate and soil fertility conditions of the region were the domination factors which affected the fat content, protein content, the O/L value and the spatial distribution of the peanut.",
        "keywords": [
            "peanut",
            "the middle and lowerreaches of Yangtze River",
            "production status",
            "quality characteristics"
        ],
        "authors": [
            {
                "name": "GUO Hong-hai",
                "org": "Shandong Institute of Agriculture Sustainable Development, Jinan, Shandong , China"
            },
            {
                "name": "YANG Li-ping",
                "org": "Shandong Institute of Agriculture Sustainable Development, Jinan, Shandong , China"
            },
            {
                "name": "LI Xin-hua",
                "org": "Shandong Institute of Agriculture Sustainable Development, Jinan, Shandong , China"
            },
            {
                "name": "YANG Ping",
                "org": "Shandong Institute of Agriculture Sustainable Development, Jinan, Shandong , China"
            },
            {
                "name": "WAN Shu-bo",
                "org": "Shandong Academy of Agricultural Sciences, Jinan, Shandong , China"
            },
            {
                "name": "WANG Rong-fu",
                "org": "College of Agronomy, Anhui Agriculture University, Hefei, Anhui , China"
            },
            {
                "name": "ZHOU Ke-jin",
                "org": "College of Agronomy, Anhui Agriculture University, Hefei, Anhui , China"
            }
        ],
        "venue": "Research of Agricultural Modernization",
        "year": 2010
    },
    "xpE8pmXE": {
        "id": "xpE8pmXE",
        "title": "Situation of Production and Development Countermeasure of Peanut in North-east China",
        "abstract": "Based on the analysis of production trends and features of peanut in North-east China, the condition of peanut quality was reviewed, and the protein content of the peanut in North-east China was quite high and the oil content was medium, while the most prominent feature of the peanut quality in North-east China was that O / L ratio is generally low. The development countermeasures was put forward to taking the market as the orientation, implementing the large-scale cultivation, strengthening the scientific and technological innovation, promoting the application of new technologies and cultivating the leading enterprises and so on, which will speed up casting \"vegetable protein source, raw materials source, and foreign exchange-earning source\" in China.",
        "keywords": [
            "peanut",
            "production trends",
            "development countermeasure",
            "peanut quality"
        ],
        "authors": [
            {
                "name": "GUO Hong-hai",
                "org": "Shandong Institute of Agriculture Sustainable Development,Jinan , China"
            },
            {
                "name": "LI Xin-hua",
                "org": "Shandong Institute of Agriculture Sustainable Development,Jinan , China"
            },
            {
                "name": "YANG Li-ping",
                "org": "Shandong Institute of Agriculture Sustainable Development,Jinan , China"
            },
            {
                "name": "YANG Ping",
                "org": "Shandong Institute of Agriculture Sustainable Development,Jinan , China"
            },
            {
                "name": "WAN Shu-bo",
                "org": "Shandong Academy of Agricultural Sciences,Jinan , China"
            },
            {
                "name": "YANG Ji-song",
                "org": "Key Laboratory of Eco-remediation and Resources Reuse,Shenyang Univirsity,Shenyang , China"
            }
        ],
        "venue": "Journal of Peanut Science",
        "year": 2010
    },
    "bLbsTxLQ": {
        "id": "bLbsTxLQ",
        "title": "Characteristics of Production and Quality of Peanut in South China",
        "abstract": "In order to guide and deepen the regional division work,utilize agriculture resource efficiently,and improve the product quality of peanut in South China,the characteristics of production and quality of peanut were studied based on GIS technology and mathematical statistics.The results showed that the planting scale and yield of peanut in this region played an important role in China,the production area was relatively concentrated and the unit yield was lower than other regions.But the production potential was promising.Diversified products based on peanut could be available.Influenced by ecological conditions,the Spanish type peanut was mainly planted in this region.The peanut had high protein and high fat content with relatively high O/L ratio which could increase the stability of peanut products.In the spatial distribution,the protein content of peanut was of no distinct diferrence,and the fat content of peanut was lower from west to east,and the O/L of peanut was higher from south to north.The O/L ratio of peanut in Hainan Island was lower with related to low rainfall in the growing period of peanut.The climate and soil fertility of the region were the dominating factors which affected the fat content,protein content,the O/L ratio and its spatial distribution of the peanut.",
        "keywords": [
            "Quality of peanut",
            "Present characteristics",
            "South China",
            "Peanut"
        ],
        "authors": [
            {
                "name": "GUO Honghai",
                "org": " Shandong Institute of Agriculture Sustainable Development,Jinan,Shandong,,China"
            },
            {
                "name": "YANG Ping",
                "org": " Shandong Institute of Agriculture Sustainable Development,Jinan,Shandong,,China"
            },
            {
                "name": "LI Xinhua",
                "org": " Shandong Institute of Agriculture Sustainable Development,Jinan,Shandong,,China"
            },
            {
                "name": "YANG Liping",
                "org": " Shandong Institute of Agriculture Sustainable Development,Jinan,Shandong,,China"
            },
            {
                "name": "WAN Shubo",
                "org": " Shandong Academy of Agricultural Sciences,Jinan,Shandong,,China"
            },
            {
                "name": "LI Shaoxiong",
                "org": " Institute of Crop,Guangdong Academy of Agricultural Sciences,Guangzhou,Guangdong,,China"
            }
        ],
        "venue": "Chinese Journal of Tropical Crops",
        "year": 2011
    },
    "4pJ4B0ps": {
        "id": "4pJ4B0ps",
        "title": "Situation of Production and Quality and Development Countermeasure of Peanut in Huang-Huai-Hai Region",
        "abstract": "Huang-Huai-Hai region is an important agricultural production base.The region has advanced technology,high unit yield,well exporting basis,formed rudiment of processing industry in peanut production,and its \u2019 planting scale and yields occupies a decisive position in China,furthermore,it is an important pillar for stabilizing vegetable oil market.Influence by conditions such as ecology and variety,peanut of the region has higher fat content,medium protein content and relatively low O/L.In spatial distribution,the trend of peanut protein content is \" high east and low west \" and \" high south and low north \" and \" high in hill region and low in plain region \" ,fat content gradually decreases form north to south,O/L gradually increases form north to south.Over standard of aflatoxin,daminozide and heavy metal content is the main obstacle of peanut export in the region.Seven cardinal principles such as developing peanut industrial superiority fully,optimizing space layout,cultivating high-quality and special varieties,expanding advanced cultivation technology,enhancing construction of standard production base,extending industrial chain and improving deep processing level must be followed for realizing sustainable development of peanut industry and ensuring national oil safety.",
        "keywords": [
            "development countermea sure",
            "peanut",
            "Huang-Huai-Hai Region",
            "present features",
            "quality of peanut"
        ],
        "authors": [
            {
                "name": "Guo Honghai",
                "org": " Shandong Institute of Agriculture Sustainable Development,Jinan "
            },
            {
                "name": "Yang Liping",
                "org": " Shandong Institute of Agriculture Sustainable Development,Jinan "
            },
            {
                "name": "Li Xinhua",
                "org": " Shandong Institute of Agriculture Sustainable Development,Jinan "
            },
            {
                "name": "Yang Ping",
                "org": " Shandong Institute of Agriculture Sustainable Development,Jinan "
            },
            {
                "name": "Wan Shubo",
                "org": " Shandong Academy of Agricultural Sciences,Jinan "
            }
        ],
        "venue": "Chinese Agricultural Science Bulletin",
        "year": 2010
    },
    "ieLbMwKl": {
        "id": "ieLbMwKl",
        "title": "Analysis of Production Cost and Market Price of Peanut in Shandong Province",
        "abstract": "The paper analyses the development of peanut industry chain of Shandong Province,and focuses on the two main effects-peanut production cost and market price.The analysis is based on the following data sources,including a variety of statistical yearbook,agricultural product cost and income data compilation,china yearbook of agricultural price survey,the price of agricultural products report data that were issued by the agriculture department of Shandong Province and ministry of agriculture,and producing data of growers.",
        "keywords": [
            "peanut industry",
            "Shandong Province",
            "production cost",
            "market price"
        ],
        "authors": [
            {
                "name": "Yang Jie",
                "org": "Shandong Institute of Agriculture Sustainable Development,Jinan,Shandong "
            },
            {
                "name": "Ji Mingchuan",
                "org": "Shandong Institute of Agriculture Sustainable Development,Jinan,Shandong "
            },
            {
                "name": "Yang Ping",
                "org": "Shandong Institute of Agriculture Sustainable Development,Jinan,Shandong "
            },
            {
                "name": "Zhang Qianqian",
                "org": "Shandong Polytechnic University,Jinan,Shandong "
            },
            {
                "name": "Liu Xiaoyu",
                "org": "Chinese Academy of Agricultural Sciences,Beijing "
            }
        ],
        "venue": "Grain Science and Technology and Economy",
        "year": 2013
    },
    "fJYEORVd": {
        "id": "fJYEORVd",
        "title": "Preliminary Studies on Spatial Distribution Prediction of Peanut O/L Ratio in China",
        "abstract": "Spatial prediction model for peanut O/L ratio is established based on nine ecological factors influencing O/L ratio.Furthermore,spatial distribution of peanut O/L ratio in China is predicted.The prediction results indicate that peanut O/L ratio increases form north to south obviously,The average value is about 1.06;High-ratio region distributes mainly in south of middle-lower Yangtze and southeastern coastal area,the average value is about 1.27;Low-ratio region distributes mainly in northeast and northwest area,the average value is about 0.83.The results have instructive significance for production and breeding department to improve peanut O/L ratio,develop quality breeding work for promoting internal quality of peanut and enhancing international competitiveness,establish peanut special production base and optimize regional production layout.",
        "keywords": [
            "spatial distribution",
            "O/L ratio",
            "peanut",
            "prediction model"
        ],
        "authors": [
            {
                "name": "Yang Liping",
                "org": "Shan dong Institute of Agriculture Sustainable Development,Jinan "
            },
            {
                "name": "Guo Honghai",
                "org": "Shan dong Institute of Agriculture Sustainable Development,Jinan "
            },
            {
                "name": "Li Xinhua",
                "org": "Shan dong Institute of Agriculture Sustainable Development,Jinan "
            },
            {
                "name": "Yang Ping",
                "org": "Shan dong Institute of Agriculture Sustainable Development,Jinan "
            },
            {
                "name": "Wan Shubo",
                "org": "Shandong Academy of Agricultural Sciences,Jinan "
            }
        ],
        "venue": "Chinese Agricultural Science Bulletin",
        "year": 2010
    },
    "2bRdI3kg": {
        "id": "2bRdI3kg",
        "title": "The Effect of Climatic Factors on Peanut Quality",
        "abstract": "In order to determine the key climatic factors affecting the peanut quality and quantify the effect degree of the key climatic factors,using the methods of correlation analysis,path analysis and stepwise regression analysis,the effects of climatic factors on peanut quality were studied based on the peanut quality data and meteorological data in growth period coming from the 18 main peanut producing provinces in China in 2008.The result showed that the protein content of peanut with the various climatic factors were not reached significant levels,the fat content of peanut and >15\u2103 accumulated temperature was highly significant positive correlation,with the temperature difference between day and night was significantly negative correlation,and the O/L of peanut with the meteorological factors in growth period were all reached highly significant level in which was very significant positive correlation with the >15\u2103 accumulated temperature and rainfall in growth period,and was very significant negative correlation with sunshine hours and day and night temperature difference in growth period.The path analysis and stepwise regression analysis showed that the effects of various climatic factors on the protein of peanut content are not large,the main climatic factor affecting the the fat content of peanut was the >15\u2103 accumulated temperature in growth period,and the main climatic factor affecting the O/L of peanut was day and night temperature difference in growth period.The relationship between the fat content,O/L of peanut and its main impact factor can be described by a linear equation.",
        "keywords": [
            "effect",
            "climatic factors",
            "peanut quality"
        ],
        "authors": [
            {
                "name": "Li Xinhua",
                "org": " Shandong Institute of Agriculture Sustainable Development,Jinan "
            },
            {
                "name": "Guo Honghai",
                "org": " Shandong Institute of Agriculture Sustainable Development,Jinan "
            },
            {
                "name": "Yang Liping",
                "org": " Shandong Institute of Agriculture Sustainable Development,Jinan "
            },
            {
                "name": "Yang Ping",
                "org": " Shandong Institute of Agriculture Sustainable Development,Jinan "
            },
            {
                "name": "Wan Shubo",
                "org": " Shan Dong Academy of Agricultural Sciences,Jinan"
            }
        ],
        "venue": "Chinese Agricultural Science Bulletin",
        "year": 2010
    },
    "cXKPJnKx": {
        "id": "cXKPJnKx",
        "title": "STUDIES ON AGRICULTURAL FUNCTION ZONING OF SHANDONG PROVINCE",
        "abstract": "Based on spatial differences,combinatorial characters and comparative advantage of the elements such as regional natural resources,economy,politics and society of Shandong Province,with the modern agriculture regional planning theory,this paper put forward the guidelines,objectives and principles on agriculture function zoning.Meanwhile,it divided 6 agricultural function regions in Shandong province,illustrated the regional function characters,confirmed the dominant and accessorial functions of agriculture,and identified extension directions of agriculture function.",
        "keywords": [
            "Shandong province",
            "agricultural function zoning",
            "function area"
        ],
        "authors": [
            {
                "name": "Guo Honghai",
                "org": "Shandong Institute of Agriculture Sustainable Development,Shandong Jinan "
            },
            {
                "name": "Yao Huimin",
                "org": "Shandong Institute of Agriculture Sustainable Development,Shandong Jinan "
            },
            {
                "name": "Yang Liping",
                "org": "Shandong Institute of Agriculture Sustainable Development,Shandong Jinan "
            },
            {
                "name": "Sun Xiaoqing",
                "org": "Shandong Institute of Agriculture Sustainable Development,Shandong Jinan "
            },
            {
                "name": "Yang Ping",
                "org": "Shandong Institute of Agriculture Sustainable Development,Shandong Jinan "
            },
            {
                "name": "Wang Yong",
                "org": "Shandong Institute of Agriculture Sustainable Development,Shandong Jinan "
            },
            {
                "name": "Zhang Weizhan",
                "org": "Shandong Institute of Agriculture Sustainable Development,Shandong Jinan "
            }
        ],
        "venue": "Chinese Journal of Agricultural Resources and Regional Planning",
        "year": 2010
    },
    "NpUJEyIJ": {
        "id": "NpUJEyIJ",
        "title": "Preliminary Studies on Spatial Distribution Prediction of Peanut Protein Content in China",
        "abstract": "Peanut quality is influenced by light,temperature,water and soil,etc..Spatial prediction model for peanut protein content is established based on 9 ecological factors influencing protein content.The spatial distribution of peanut protein content in China is predicted by using this model.The results showed that peanut protein content increases gradually from north to south,and the regions with high-content are mainly distributed in south to the middle-lower valley of the Yangtze River.The minimum value is 13.3% in Jilin Province,the maximum value is 32.9% in Taiwan Province,and the average value is 26.9%.The above prediction results are of guiding significance for peanut production and breeding departments to improve peanut protein quality,carry out quality breeding work and establish special peanut producing base and optimize regional production distribution.",
        "keywords": [
            "spatial distribution",
            "peanut",
            "prediction model",
            "protein content"
        ],
        "authors": [
            {
                "name": "YANG Li-ping",
                "org": "Shandong Sustainable Agricultural Development Institute,Ji'nan "
            },
            {
                "name": "GUO Hong-hai",
                "org": "Shandong Sustainable Agricultural Development Institute,Ji'nan "
            },
            {
                "name": "LI Xin-hua",
                "org": "Shandong Sustainable Agricultural Development Institute,Ji'nan "
            },
            {
                "name": "YANG Ping",
                "org": "Shandong Sustainable Agricultural Development Institute,Ji'nan "
            },
            {
                "name": "WAN Shu-bo",
                "org": "Shandong Academy of Agricultural Sciences,Ji'nan ,China"
            }
        ],
        "venue": "Journal of Agricultural Science and Technology",
        "year": 2010
    },
    "8jehTXE3": {
        "id": "8jehTXE3",
        "title": "Studies on Peanut Quality Regional Planning in China\u2014\u2014Guiding Thoughts,Aims and Principle",
        "abstract": "In order to guide and deeply carry out regional division of peanut production and enhance the regional peanut producing capacity,this paper puts forward several guiding thoughts according to China's overall strategy for regional agriculture development.They are:taking the concept of scientific development as guidance;ensuring the national fuel security as overall objective;taking efficient and reasonable use of agricultural resources;standardizing spatial order of peanut production as main guideline;strengthening spatial constraint function of peanut product quality;rationally allocating regional edible oil sources and fats,vegetable protein sources,processing raw material resources,foreign exchange-earning resources and agriculture biological complementary resources.The diferentiation of peanut quality should follow the coupling principles,such as:relationship between light,temperature,water,soil,cultivation measures and peanut quality;quality heredity of varieties and its coordination with ecological environment;peanut consumption channel and its commercial value;and the operability of taking major producing areas as principle with paying attention to programming.",
        "keywords": [
            "principle",
            "objective",
            "guiding thought",
            "peanut quality regional planning"
        ],
        "authors": [
            {
                "name": "GUO Hong-hai",
                "org": "Shandong Sustainable Agriculture Development Institute,Jinan "
            },
            {
                "name": "YANG Li-ping",
                "org": "Shandong Sustainable Agriculture Development Institute,Jinan "
            },
            {
                "name": "LI Xin-hua",
                "org": "Shandong Sustainable Agriculture Development Institute,Jinan "
            },
            {
                "name": "YANG Ping",
                "org": "Shandong Sustainable Agriculture Development Institute,Jinan "
            },
            {
                "name": "WAN Shu-bo",
                "org": "Shandong Academy of Agricultural Sciences,Jinan ,China"
            }
        ],
        "venue": "Journal of Agricultural Science and Technology",
        "year": 2010
    },
    "gK9zdYmu": {
        "id": "gK9zdYmu",
        "title": "The Characteristics of Production and Quality of Peanut in Yungui Plateau",
        "abstract": "In order to guide and deepen the regional division of peanut production in Yungui Plateau,use of agricultural resources reasonably and efficiently and provide the theoretical basis for improving the quality of peanut products,the characteristics of production and quality of peanut in Yungui Plateau were studied based on GIS technology and the methods of mathematical statistics.The result showed that peanut planting in the Yungui Plateau was mainly distributed in the hilly areas bellow 1600 meters,the dam areas and the valley basins which belonged to the valley of Nanpan river,Jinsha river,Nu river,Wu river and Qingshui river.In the peanut production there were some problems such as the single planting species of peanut,serious degradation of species characteristics,management extensive,low unit yield and weak of peanut processing.Influenced by ecological conditions,the qualities of peanut belong to the region in which the peanut had the medium protein content in consumption and low fat content in oil,furthermore the O/L of the peanut was relatively high.In the spatial distribution,the protein content and fat content of peanut was higher in the east and in the north-west of the region,and the O/L of the peanut increased from east to west and was the same trend from north to south.Meanwhile the peanut quality was related to the elevation,and the value of the quality indexes decreased with the increasing altitude.The peanut qualities have affected by large vertical terrain elevations and stereoscopic climate.",
        "keywords": [
            "peanut",
            "Yungui Plateau",
            "quality of peanut",
            "present characteristics"
        ],
        "authors": [
            {
                "name": "Guo Honghai",
                "org": "Shan Dong Institute of Agriculture Sustainable Development,Jinan "
            },
            {
                "name": "Yang Ping",
                "org": "Shan Dong Institute of Agriculture Sustainable Development,Jinan "
            },
            {
                "name": "Yang Liping",
                "org": "Shan Dong Institute of Agriculture Sustainable Development,Jinan "
            },
            {
                "name": "Li Xinhua",
                "org": "Shan Dong Institute of Agriculture Sustainable Development,Jinan "
            },
            {
                "name": "Wan Shubo",
                "org": "ShanDong Academy of Agricultural Sciences,Jinan "
            },
            {
                "name": "Fu Minglian",
                "org": "YuNan Academy of Agricultural Sciences,Kunming "
            }
        ],
        "venue": "Chinese Agricultural Science Bulletin",
        "year": 2011
    },
    "x0d0sDV7": {
        "id": "x0d0sDV7",
        "title": "Characteristics of production and quality of peanut in Huang-Huai-Hai region",
        "abstract": "In order to guide the regional division of peanut production in Huang-Huai-Hai region, and efficiently utilize the agricultural resources, and provide the theoretical basis for improving peanut quality, the characteristics of production and quality of peanut in Huang-Huai-Hai region were studied based on GIS technology and mathematical statistics. The results show that peanut cultivation technology is advanced in the region producing higher unit yield. Peanut export is developed and processing industry is forming. Therefore, the region occupies a decisive position in peanut production in China, as an important pillar for stabilizing vegetable oil market. Influenced by ecological conditions, the mainly planted cultivar type in the region is virginia type, whose protein content is medium for edible cultivars, and fat content is higher for oil cultivars, with relatively low oleic acid/linoleic acid (O/L) ratio. Overproof contents of aflatoxin, daminozide and heavy metals in peanut are the main obstacles of peanut export in the region. The spatial distribution of protein content characterizes higher in the east, south and hilly area, lower in the west, north, and plain area. The fat content is higher in the north and hilly area, lower in the south and plain area, while O/L ratio presents increasing tendency from west to east and from north to south. The climate and soil fertility of the region are the domination factors affecting peanut fat and protein contents, and O/L value ratio and their spatial distribution of the peanut.",
        "keywords": [
            "Quality",
            "Production",
            "Huang-Huai-Hai region",
            "Spacial distribution",
            "Peanut"
        ],
        "authors": [
            {
                "name": "GUO Hong-Hai",
                "org": " Shandong Institute of Agriculture Sustainable Development, Jinan , China"
            },
            {
                "name": "YANG Li-Ping",
                "org": " Shandong Institute of Agriculture Sustainable Development, Jinan , China"
            },
            {
                "name": "LI Xin-Hua",
                "org": " Shandong Institute of Agriculture Sustainable Development, Jinan , China"
            },
            {
                "name": "YANG Ping",
                "org": " Shandong Institute of Agriculture Sustainable Development, Jinan , China"
            },
            {
                "name": "WAN Shu-Bo",
                "org": " Shandong Academy of Agricultural Sciences, Jinan , China"
            }
        ],
        "venue": "Chinese Journal of Eco-Agriculture",
        "year": 2010
    },
    "eFZxh78a": {
        "id": "eFZxh78a",
        "title": "Sedimentary characteristics of the Sinian Dengying Formation in Pengshui,Chongqing",
        "abstract": "The petrographic and sedimentological characteristics of the dolostones from the Sinian Dengying Formation in Pengshui,Chongqing are explored on the basis of the Dengying Formation section in the coral part of the Laochangping anticline.These dolostones may be divided,from the base upwards,into two parts: \"algae-rich\" and \"silica-rich\" intervals.The sedimentary environments consist of the tidal-flat to restricted platform subfacies,including the lagoon,subtidal,intertidal and supratidal microfacies.The sedimentary model has been constructed for the Sinian Dengying Formation in the upper Yangtze area.Vertically,the Dengying Formation once went through two phases of sea-level changes dominated by regression and displays the shallowing-upward depositional sequences.Horizontally,the sedimentary environments passed,from NW to SE,into the tidal flat-lagoon through restricted platform to the open platform,and finally to the platform margin and continental shelf.",
        "keywords": [
            "tidal flat-restricted platform",
            "Pengshui",
            "Dengying Formation",
            "sedimentary facies",
            "Chongqing"
        ],
        "authors": [
            {
                "name": "ZHAO Zhan",
                "org": "(Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China)"
            },
            {
                "name": "LIU BO",
                "org": "(Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China)"
            },
            {
                "name": "LIU Jian-qing",
                "org": "(Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China)"
            },
            {
                "name": "QIU Dong-zhou",
                "org": "(Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China)"
            },
            {
                "name": "WANG Zheng-jiang",
                "org": "(Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China)"
            },
            {
                "name": "YANG Ping",
                "org": "(Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China)"
            },
            {
                "name": "ZHUO Jie-wen",
                "org": "(Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China)"
            }
        ],
        "venue": "Sedimentary Geology and Tethyan Geology",
        "year": 2010
    },
    "rnvy4eIg": {
        "id": "rnvy4eIg",
        "title": "The discovery and geological implications of the Neoproterozoic A-type granites in the upper Yangtze craton",
        "abstract": "Little has long been known for the Niulangba biotite granites in Ebian,Sichuan within the upper Yangtze craton.The purpose of this paper is to present,for the first time,our recent results of SHRIMP zircon U-Pb dating and relevant geochemical data.The Niulangba granites are characterized by higher SiO2(SiO2>75%) contents,lower Ca(CaO=0.46% to 0.20 %) contents,depletion in Mg,enrichment in alkali(Na2O + K2O=8.31% to 9.28%) and Al(A/KNC=1.02 to 1.12).The geochemistry of the trace elements suggests the highly depletion in Ba,Sr,Eu(\u03b4Eu=0.05 to 0.08) and enrichment in Rb,Th and U.The 104*Ga/Al ratios for the bulk-rock samples range between 2.6 and 2.9.The high field strength elements Zr,Y and Ga have higher contents,and no anomaly has been identified.It can be seen from the major and trace element analyses that the Niulangba granites belong to the aluminous A2-subtype granites.The Y/Nb ratios ranging from 5.0 to 5.9 and Nb/Ta ratios ranging from 4.4 to 5.0 have disclosed that the magmatic source areas were once subjected to highly hybridization of continental compositions.The SHRIMP zircon U-Pb ages are dated at 826 \u00b1 21.4 Ma,in general agreement with the previous data for the Neoproterozoic granites from the southeastern Yangtze craton.This implies that the Niulangba granites should be assigned to part of the highly magmatic activity within the pan-Yangtze craton during this period.These granites may result from the mantle plume-associated crust-mantle interaction against the breakup of the suppercontinent Rodinia during the middle Neoproterozoic.",
        "keywords": [
            "A-type granite",
            "SHRIMP zircon U-Pb dating",
            "breakup of the suppercontinent Rodinia",
            "lithogeochemistry",
            "upper Yangtze craton",
            "Neoproterozoic"
        ],
        "authors": [
            {
                "name": "WANG Zheng-jiang",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            },
            {
                "name": "WANG Jian",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            },
            {
                "name": "YANG Ping",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            },
            {
                "name": "XIE Shang-ke",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China;Graduate School,Chinese Academy of Geological Sciences,Beijing ,China"
            },
            {
                "name": "ZHUO Jie-wen",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            },
            {
                "name": "HE Jiang-lin",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China;Graduate School,Chinese Academy of Geological Sciences,Beijing ,China"
            }
        ],
        "venue": "Sedimentary Geology and Tethyan Geology",
        "year": 2011
    },
    "wZtESEfI": {
        "id": "wZtESEfI",
        "title": "Dolostone reservoirs and their genesis in the Zaring oil pool in southern Qiangtang Basin",
        "abstract": "The present paper gives a detailed description of the dolostone reservoirs and their genesis in the Zaring oil pool in southern Qiangtang Basin on the basis of thin sections,cast sections,capillary pressure curves and cathodeluminescent images.The dolostones have experienced several types of postdepositional diagenetic modifications,of which dolomitization,dissolution,recrystallization and tectonic stress processes have exerted an important effect on porosity and permeability.The accommodation spaces include intercrystal pores and intercrystal solution openings.The well-developed rimmed textures indicate that the dolostones in the study area resulted from the diagenetic replacement of limestones by mixed meteoric-marine pore fluids.",
        "keywords": [
            "Qinghai-Xizang Plateau",
            "reservoirs",
            "Zaring",
            "dolostone",
            "southern Qiangtang Basin"
        ],
        "authors": [
            {
                "name": "CHEN Wen-bin",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            },
            {
                "name": "YANG Ping",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            },
            {
                "name": "ZHANG Yu-jie",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            },
            {
                "name": "PENG Zhi-min",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            }
        ],
        "venue": "Sedimentary Geology and Tethyan Geology",
        "year": 2006
    },
    "Kjg6e5zM": {
        "id": "Kjg6e5zM",
        "title": "Domal structures: An important type of folds in northern Qiangtang",
        "abstract": "The domal structures are well displayed as an important type of folds in northern Qiangtang Basin,and interpreted to be the products of the superimposition of the nearly NS-trending anticlines created by the nearly EW-trending compressive stress during the phase \u2162 of the Yanshanian onto the pre-existing nearly EW-trending anticlines.These domal structures are believed to be the most important trap structures in northern Qiangtang Basin.Emphasis in the future exploration will be placed on the domal structures in the nearly EW-trending large- and medium-sized anticlines in order to delineate the targets of oil and gas exploration in the favourable zones.",
        "keywords": [
            "northern Qiangtang Basin",
            "Qinghai-Xizang Plateau",
            "oil and gas",
            "domal structure"
        ],
        "authors": [
            {
                "name": "JIA Bao-jiang",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            },
            {
                "name": "LIU Jian-qing",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            },
            {
                "name": "YANG Ping",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            }
        ],
        "venue": "Sedimentary Geology and Tethyan Geology",
        "year": 2006
    },
    "wTyO4tfN": {
        "id": "wTyO4tfN",
        "title": "Geochemical characteristics and oil source correlation of Dengying formation paleo-reservior in Jinsha",
        "abstract": "In order to study the source of sinian paleo-reservior bitumen of South China in detail,Dengying formation paleo-reservior in Yankong,Jinsha has been systematically investigated.The bitumens enrich mainly in the dolarenite,oolitic dolomite and algal dolomite in the upper Dengying formation.The bitumens are massive enrichment,hard,sewage chiral,occur mainly in intercrystalline dissolution pore,mould pore and dissolution cave of dolomite,and show black solid state,microscopic observation show bitumens have the features with mosaic-like structure.The organic carbon content of bituminous dolomite rang from 0.52% to 1.89%,indicating bituminous dolomite have higher organic matter content.Chloroform bitumen \"A\" and genetic potential of bituminous dolomite is lower due to oxidation of the pyrolysis and surface water washout filter.Organic carbon isotopic of bitumen ranges from \u201333.22\u2030 to \u201332.06\u2030,V/(V+Ni) ratio is higher with the value of 0.75-0.94,high bitumen reflectance ranges from 2.95% to 3.86%.These samples have double reflection and high degree of thermal evolution.H/C of most samples is less than 0.5.Comprehensive studies shown that bitumens exposured to high temperature thermal evolution in the geological history,which is the solid pyrobitumen from high temperature pyrolysis of crude oil.Biomarker compounds,organic carbon isotope,monomer hydrocarbon isotopes and V/(V+Ni) contrast analysis show that these bitumens come from the black rock series of the Lower Cambrian Niutitang formation.",
        "keywords": [
            "Jinsha",
            "bitumens",
            "biomarker",
            "oil source correlation",
            "Organic carbon isotopic",
            "paleo-reseservoir",
            "V/(V+Ni)"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Chengdu Institude of Geology and Mineral Resources,Chengdu ,China"
            },
            {
                "name": "XIE Yuan",
                "org": "Chengdu Institude of Geology and Mineral Resources,Chengdu ,China"
            },
            {
                "name": "WANG Zheng-jiang",
                "org": "Chengdu Institude of Geology and Mineral Resources,Chengdu ,China"
            },
            {
                "name": "LIU Jia-hong",
                "org": "Chengdu Institude of Geology and Mineral Resources,Chengdu ,China"
            }
        ],
        "venue": "Geochimica",
        "year": 2012
    },
    "gjj1MOFd": {
        "id": "gjj1MOFd",
        "title": "Sedimentary Characteristics of Late Permian in Western Hubei Province and Evolution of Inter-Platform Rift",
        "abstract": "In the Middle-Late Permian,with the open of paleo-tethys,on the regional tension background,the western Hubei provinct(Exi area) was transformed from the gulf into the trough,and developed into an inter-platform rift(trough) in the northestern margin of carbonate platform in the Middle-Upper Yangtze block,which was controlled by Jianshi-Yushan-Pengshui fault.This inter-platform rift (trough) plays an important role in the control of sedimentary facies and distribution of the organic reefs of Late Permian\u2014Early Triassic in eastern Sichuan and Exi area.",
        "keywords": [
            "platform-edge reef bank",
            "Exi rift trough",
            "Late Permian",
            "marine oil-gas geology",
            "siliceous rock",
            "Jianshi-Yushan-Pengshui fault"
        ],
        "authors": [
            {
                "name": "ZHUO Jie-wen",
                "org": "Chengdu Centre,China Geological Survey,Chengdu,Sichuan ,China;Graduate School,Chinese Academy of Geological Sciences,Beijing ,China"
            },
            {
                "name": "WANG Jian",
                "org": "Chengdu Centre,China Geological Survey,Chengdu,Sichuan ,China"
            },
            {
                "name": "WANG Zheng-jiang",
                "org": "Chengdu Centre,China Geological Survey,Chengdu,Sichuan ,China;Graduate School,Chinese Academy of Geological Sciences,Beijing ,China"
            },
            {
                "name": "XIE Yuan",
                "org": "Chengdu Centre,China Geological Survey,Chengdu,Sichuan ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Chengdu Centre,China Geological Survey,Chengdu,Sichuan ,China"
            },
            {
                "name": "LIU Jian-qing",
                "org": "Chengdu Centre,China Geological Survey,Chengdu,Sichuan ,China"
            },
            {
                "name": "ZHAO Zhan",
                "org": "Chengdu Centre,China Geological Survey,Chengdu,Sichuan ,China"
            }
        ],
        "venue": "Xinjiang Petroleum Geology",
        "year": 2009
    },
    "Wt60n43J": {
        "id": "Wt60n43J",
        "title": "Shrimp zircon U-Pb dating for crystal tuff from hongzixi formation of banxi group in xiushan area, chongqing, and its significance",
        "abstract": "There has long existed considerable controversy concerning the epoch and stratigraphic division of Banxi Group. Based on restudying the sedimentary sequence and evolution of Banxi Group in Xiushan -Fanjingshan area, the authors performed the crystal tuff SHRIMP zircon U-Pb dating for Hongzixi Formation of Banxi Group in Xiushan area. The result suggests that the expansion of the early Banxi basin ended at about 790 Ma, followed immediately by the quick infilling and differential uplifting stage. The deposition epochof Banxi Group in Xiushan-Fanjingshan area corresponded to that of the lower part of Banxi Group in western Hunan and that of Xiajiang Group in eastern Guizhou, with the deposition duration being between 820Ma and 790Ma. It was the early infilling of the rift basin under the background of the break -up of Rodinia supercontinent in middle Neoproterozoic.",
        "keywords": [
            "Banxi Group",
            "Crystal tuff",
            " SHRIMP zircon U- Pb dating",
            "Liangqiao in Xiushan area",
            "Neoproterozoic"
        ],
        "authors": [
            {
                "name": "WANG Zheng-jiang",
                "org": "Chengdu Institute of Geology and Mineral Resources(Chengdu Institute of Geology and Mineral Resources,Chengdu College of Geology,Chengdu Institute of Meteorology),Chengdu,China"
            },
            {
                "name": "Jianhua Wang",
                "org": "Chengdu Institute of Geology and Mineral Resources(Chengdu Institute of Geology and Mineral Resources,Chengdu College of Geology,Chengdu Institute of Meteorology),Chengdu,China"
            },
            {
                "name": "Yuan Xie",
                "org": "Chengdu Institute of Geology and Mineral Resources(Chengdu Institute of Geology and Mineral Resources,Chengdu College of Geology,Chengdu Institute of Meteorology),Chengdu,China"
            },
            {
                "name": "Ping Yang",
                "org": "Chengdu Institute of Geology and Mineral Resources(Chengdu Institute of Geology and Mineral Resources,Chengdu College of Geology,Chengdu Institute of Meteorology),Chengdu,China"
            },
            {
                "name": "ZHUO Jie-wen",
                "org": "Chengdu Institute of Geology and Mineral Resources(Chengdu Institute of Geology and Mineral Resources,Chengdu College of Geology,Chengdu Institute of Meteorology),Chengdu,China"
            }
        ],
        "venue": "Geology in China",
        "year": 2009
    },
    "iHaMXWHG": {
        "id": "iHaMXWHG",
        "title": "Explorative Prospect of Shale Gas of Lower Silurian in Middle-Upper Yangtze Area",
        "abstract": "The Longmaxi formation of the Silurian in Middle-Upper Yangtze area is a set of high-quality hydrocarbon source developed in restricted shallow sea environment.Especially the black shale in the deposition centers of southern Sichuan,northern Sichuan,southeastern Chongqing to northern Guizhou is most developed,with big thickness and high organic matter abundance.The type of kerogen in the southern and northern Sichuan is dominated by type-I and the maturity of organic matter is in the middle-late stage of high maturity,which is dominated by generating pyrolysis gas-wet gas;The type of kerogen in the southeastern Chongqing to northern Guizhou is type-\u21611 and the maturity of organic matter reaches overmature,dominated by generating dry gas.According to the organic geochemical parameters in these areas and the logging data from drilling-encountered this formation as well as the shale gas explorative practices from North America,it is suggested that Longmaxi formation of the Silurian in Middle-Upper Yangtze area has favorable conditions to form shale gas reservoirs.There exist gas logging abnormality and many of abnormal pressure zones in this formation in drilling well of Jianshen-2.These show enormous potentials for shale gas exploration of Longmaxi formation in the Middle-Upper Yangtze area.",
        "keywords": [
            "lithofacies paleogeography",
            "shale gas",
            "Middle-Upper Yangtze area",
            "Longmaxi formation",
            "organic carbon content"
        ],
        "authors": [
            {
                "name": "ZHANG Hai-quan",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu,Sichuan ,China"
            },
            {
                "name": "YU Qian",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu,Sichuan ,China"
            },
            {
                "name": "LI Yu-xi",
                "org": "Strategic Study Center for Oil-Gas Resources,Ministry of Land and Resources P.R.C,Beijing ,China"
            },
            {
                "name": "YAN Jian-fei",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu,Sichuan ,China"
            },
            {
                "name": "LIU Wei",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu,Sichuan ,China"
            },
            {
                "name": "MEN Yu-peng",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu,Sichuan ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu,Sichuan ,China"
            }
        ],
        "venue": "Xinjiang Petroleum Geology",
        "year": 2011
    },
    "e0ZAc4YY": {
        "id": "e0ZAc4YY",
        "title": "The Dolomite Fabric Characteristics and Lead Isotope Significance of the Ancient Oil Accumulation in Long'eni-Angdar Lake,Qiangtang Basin",
        "abstract": "Based on a systematic lithologic and sedimentary facies analysis,this paper deals in detail with Pb isotope characteristics of dolomite and associated limestone in the Long'eni-Angdar Co ancient oil accumulation.The dolomite and associated calcite seem to have the same Pb source,which was derived mainly from metamorphic rocks,magmatic rocks and recycled Triassic deposits in the uplift area of Qiangtang basin,thus probably being multi-source mixed anomalous lead from the mantle,the orogenic belt and the crust.The Pb content has distinctive relationship with sedimentary facies,still under the control of the sedimentary process.Late tectonic activities did not bring large quantities of hot fluids from the interior of the earth for the replacement of dolomite,and hence dolomite still preserves many typical structures of genetic significance,such as fogged center and clear margin,ring structure and generations of minerals,remnant oolitic texture and algal stromatolite.The dolomite might have resulted from mixed water replacement of calcite,and tectonic activities only exerted late alteration effects on dolomite.",
        "keywords": [
            "dolomite",
            "Pb isotope",
            "lithologic structure",
            "Qiangtang basin"
        ],
        "authors": [
            {
                "name": "LIU Jianqing",
                "org": " Chengdu Institute of Geology and Mineral Resources,Chengdu,Sichuan "
            },
            {
                "name": "CHEN Wenbin",
                "org": " Chengdu Institute of Geology and Mineral Resources,Chengdu,Sichuan "
            },
            {
                "name": "YANG Ping",
                "org": " Chengdu Institute of Geology and Mineral Resources,Chengdu,Sichuan "
            },
            {
                "name": "CHEN Wenxi",
                "org": " Chengdu Institute of Geology and Mineral Resources,Chengdu,Sichuan "
            },
            {
                "name": "FU Xiugen",
                "org": " Chengdu Institute of Geology and Mineral Resources,Chengdu,Sichuan "
            }
        ],
        "venue": "Acta Geoscientica Sinica",
        "year": 2008
    },
    "kOGl9OMF": {
        "id": "kOGl9OMF",
        "title": "The Discovery of Macroscopic Tubular Fossils from Sinian Liuchapo Formation in Xinhua County,Hunan Province and Its Significance",
        "abstract": "Centimeter-scale macroscopic tubular fossil was discovered for the first time in silicalite of Sinian Liuchapo Formation in Xinhua County,Hunan Province.Its clear structure and body size can be compared with Gaojiashan biota in Ningqiang County of Shaanxi Province and Liaotuo tubular fossils of Hubei Province.The tubular fossils may be a new biological species and the most reliable metazoa in this area.In this paper the significance of the discovery in the study of early biological evolution has been discussed in combination with Ediacaran biota and biota in its upper and lower horizons.",
        "keywords": [
            "tubular fossils",
            "Liuchapo Formation",
            "Sinian"
        ],
        "authors": [
            {
                "name": "LIU Jian-qing",
                "org": " Department of Sedimentary Petrography and Energy Resource,Chengdu Institute of Geology and Mineral Resources,Chengdu,Sichuan "
            },
            {
                "name": "XIE Yuan",
                "org": " Department of Sedimentary Petrography and Energy Resource,Chengdu Institute of Geology and Mineral Resources,Chengdu,Sichuan "
            },
            {
                "name": "ZHAO Zhan",
                "org": " Department of Sedimentary Petrography and Energy Resource,Chengdu Institute of Geology and Mineral Resources,Chengdu,Sichuan "
            },
            {
                "name": "LIN Jia-shan",
                "org": " Department of Sedimentary Petrography and Energy Resource,Chengdu Institute of Geology and Mineral Resources,Chengdu,Sichuan "
            },
            {
                "name": "YANG Ping",
                "org": " Department of Sedimentary Petrography and Energy Resource,Chengdu Institute of Geology and Mineral Resources,Chengdu,Sichuan "
            }
        ],
        "venue": "Acta Geoscientica Sinica",
        "year": 2012
    },
    "VUBZlRAq": {
        "id": "VUBZlRAq",
        "title": "Paleo-weathering crust at the top of Sinian Dengying Formation in northern Guizhou and its petroleum exploration significance",
        "abstract": "The paleo-weathering crust is important for karst reservoir formation and hydrocarbon accumulation.Field geological survey reveals that there exists a paleo-weathering crust at the top of Sinian Dengying Formation in northern Guizhou,which was formed by Tongwan tectonic movement and is composed of yellowish brown scoriaceous clay rock.Its geochemistry is characterized by depletion of MgO and relative enrichment of SiO 2,Al 2 O 3,Fe 2 O 3,Fe 2 O,P 2 O 5 and TiO 2.The paleo-weathering crust is somewhat different in different facies,which results in the difference of underlying karst reservoirs.The platform edge shallow facie was uplifted strongly,and its primary pores were favorable for the meteorological water eluviation,and also favorable for karstification to improve the dolomite reservoir,thus forming lots of reservoir spaces,such as?cavern,dissolved seam,intragranular pore and intergranular pore.On the contrary,the other facies were affected relatively weakly by karstification,and the reservoir quality was unfavorable.It is concluded that the buried paleo-weathering crust of the shallow facie at the top of Dengying Formation may become an important exploration area.",
        "keywords": [
            "Dengying Formation",
            "Tongwan tectonic movement",
            "karst reservoir",
            "paleo-weathering crust"
        ],
        "authors": [
            {
                "name": "LIU Jia-hong",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            },
            {
                "name": "YANG Ping",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            },
            {
                "name": "WANG Zheng-jiang",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            },
            {
                "name": "ZHUO Jie-wen",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            }
        ],
        "venue": "Geology in China",
        "year": 2012
    },
    "NP3Qdr4v": {
        "id": "NP3Qdr4v",
        "title": "THE SEDIMENTARY ENVIRONMENT OF THE XUESHAN FORMATION IN THE NORTHERN DEPRESSION, QIANGTANG BASIN AND ITS PALAEOGEOGRAPHIC SIGNIFICANCE",
        "abstract": "Taken the Xueshan Formation in the Northern Depression of Qiangtang Basin as an example,the source of the Xueshan Formation deposits,the paleoecology,the carbon and oxygen isotope character,the sedimentary sequence,the granulometric character and palaeocurrent indicator have been studied in this paper,accordingly discussing the sedimentary environment and its significance.With all the proofes and relevant discusses presented above,we can see that the Upper Jurassic\u2014Lower Cretaceous Xueshan Formation should be formed in palaeodelta sedimentary environment.During that time,the central uplift zone of the Qiangtang Basin raised above sea level for tectonic reason,and provided stable deposits from central uplift to the Northern Depression.The deposits of the Xueshan Formation therefore show manifest braided river characters.",
        "keywords": [
            "braided river",
            "Cretaceous",
            "Jurassic",
            "Tibet",
            "delta",
            "Qiangtang Basin",
            "Northern Depression",
            "Xueshan Formation"
        ],
        "authors": [
            {
                "name": "LIU Jian-qing",
                "org": " Chengdu Institute of Geology and Mineral Resources, Chengdu 2) Field Geological Survey of Sichuan Bureau of Geology and Mineral Resources,Chengdu "
            },
            {
                "name": "JIA Bao-jiang",
                "org": " Chengdu Institute of Geology and Mineral Resources, Chengdu 2) Field Geological Survey of Sichuan Bureau of Geology and Mineral Resources,Chengdu "
            },
            {
                "name": "YANG Ping",
                "org": " Chengdu Institute of Geology and Mineral Resources, Chengdu 2) Field Geological Survey of Sichuan Bureau of Geology and Mineral Resources,Chengdu "
            },
            {
                "name": "CHEN Yu-lu",
                "org": ""
            },
            {
                "name": "PENG Bo",
                "org": ""
            },
            {
                "name": "LI Zhen-jiang",
                "org": ""
            }
        ],
        "venue": "Journal of Stratigraphy",
        "year": 2008
    },
    "HkzZQXHc": {
        "id": "HkzZQXHc",
        "title": "The Geochenical Characteristics of the Middle Jurassic Source Rocks in Southern Qiangtang Basin",
        "abstract": "The source rocks in the middle Jurassic Buqu formation and Xiali formation are most important source rocks in the southern Qiangtang Basin. The source rocks in Buqu formation is dominated by gentle slope limestone and the one in Xiali formation by shallow shelf and basinal- slope facies claystone. Abundance of organic matter, organic types and maturity of source rocks were analyzed and the geochemical characteristics of source rocks were correlated with those of the new discovered oil show. It was indicated that the oil show in Quruiqianainan area was generated in the Late Jurassic from the Buqu limestone.",
        "keywords": [
            "oil-to source correlation",
            "biomarker",
            "\u03b413C isotope",
            "source rock",
            "geochemistry",
            "southern Qiangtang Basin"
        ],
        "authors": [
            {
                "name": "Yang Ping",
                "org": "Chengdu Research Institute of Geology & Mineral Resources,Chengdu,Sichuan ,China"
            },
            {
                "name": "Yin Fu-guang",
                "org": "Chengdu Research Institute of Geology & Mineral Resources,Chengdu,Sichuan ,China"
            },
            {
                "name": "Liu Jian-qing",
                "org": "Chengdu Research Institute of Geology & Mineral Resources,Chengdu,Sichuan ,China"
            },
            {
                "name": "Chen Wen-bin",
                "org": "Chengdu Research Institute of Geology & Mineral Resources,Chengdu,Sichuan ,China"
            }
        ],
        "venue": "West China Petroleum Geosciences",
        "year": 2006
    },
    "dqcqNykf": {
        "id": "dqcqNykf",
        "title": "Fluid Inclusion and Hydrocarbon Accumulation in Longweihu Area of North Qiangtang Basin",
        "abstract": "The occurrence and homogenization temperature of fluid inclusion as well as the fluorescent indicator of organic inclusion from Xiali formation (Middle Jurassic) and Suowa formation (Upper Jurassic) in Longwei area of north Qiangtang basin are analyzed, indicating that the inclusion in this area is of multiple types with braded and banded distribution. The homogeneous temperature is of multiple peak values. The organic inclusion is of characters of blue-white and yellow-green fluorescence. It is believed by combination of the source rock's organic matter evolution and oil source studies that there existed two large-scale processes of hydrocarbon generation, migration and accumulation in late stage of Late Jurassic to early stage of Early Cretaceous and Kangtuo stage of Miocene, respectively.",
        "keywords": [
            "North Qiangtang basin",
            "hydrocarbon accumulation",
            "fluid inclusion",
            "homogeneous temperature"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Chengdu Institute of Geologic Mineral Resources, Chengdu, Sichuan , China"
            },
            {
                "name": "JIA Bao-jiang",
                "org": "Chengdu Institute of Geologic Mineral Resources, Chengdu, Sichuan , China"
            },
            {
                "name": "LIU Jian-qing",
                "org": "Chengdu Institute of Geologic Mineral Resources, Chengdu, Sichuan , China"
            },
            {
                "name": "CHEN Yu-lu",
                "org": "Sichuan Regional Geologic Survey Team, Chengdu, Sichuan , China"
            },
            {
                "name": "PENG Bo",
                "org": "Sichuan Regional Geologic Survey Team, Chengdu, Sichuan , China"
            }
        ],
        "venue": "Xinjiang Petroleum Geology",
        "year": 2007
    },
    "VgRQTEkt": {
        "id": "VgRQTEkt",
        "title": "Characteristics of the Paleo-Oil Dolomite REE Geochemistry of Buqu Formation in Southern Part of the Central Uplift Zone of Qiangtang Basin and It's Significance",
        "abstract": "Based on systematic analysis of lithological composition,microstructure and sedimentary facies,in this paper many discusses have been conducted for the REE characteristics of Longeni-Angdanrco paleo-oil dolomite in southern part of the central uplift zone of Qiangtang basin.The amount of \u2211REE in dolomite and concomitant calcite is lower in comparison with other carbonates in China,and is still under the control of sedimentary facies and process.The HREE of dolomite is even more impoverished than LREE compared to concomitant calcite in this area.In distributed patterns,all the carbonates show a complicate model,and the dolomite is even more flat compared to concomitant calcite.For the two typical indexes,the \u03b4Eu of calcite is higher,and the \u03b4Ce of dolomite is higher.All these show that REE have been undergoing an impoverished process in dolomitization,and the calcite has been formed in deep water deoxidized environment,the dolomite being formed in shallow water oxidized environment.The dolomite in this area should be the result of mixed water replacement to calcite.",
        "keywords": [
            "dolomite",
            "mixed water replacement",
            "Qiangtang Basin",
            "REE"
        ],
        "authors": [
            {
                "name": "LIU Jian-qing",
                "org": "Department of Sedimentary Petrography and Energy Resources,Chengdu Institute of Geology and Mineral Resources,Chengdu "
            },
            {
                "name": "JIA Bao-jiang",
                "org": "Department of Sedimentary Petrography and Energy Resources,Chengdu Institute of Geology and Mineral Resources,Chengdu "
            },
            {
                "name": "YANG Ping",
                "org": "Department of Sedimentary Petrography and Energy Resources,Chengdu Institute of Geology and Mineral Resources,Chengdu "
            },
            {
                "name": "CHEN Wen-bin",
                "org": "Department of Sedimentary Petrography and Energy Resources,Chengdu Institute of Geology and Mineral Resources,Chengdu "
            },
            {
                "name": "CHEN Wen-xi",
                "org": "Department of Sedimentary Petrography and Energy Resources,Chengdu Institute of Geology and Mineral Resources,Chengdu "
            },
            {
                "name": "FU Xiu-gen",
                "org": "Department of Sedimentary Petrography and Energy Resources,Chengdu Institute of Geology and Mineral Resources,Chengdu "
            }
        ],
        "venue": "Acta Sedimentologica Sinica",
        "year": 2008
    },
    "srmLNU34": {
        "id": "srmLNU34",
        "title": "The Application of Carbon, Oxygen and Strontium Isotopes to the Study of Middle-Upper Jurassic Sequence Stratigraphy in Longweicuo Area, Qiangtang Basin",
        "abstract": "Based on an analysis of outcrops in Lonweicuo area, this paper deals with the Middle-Late Jurassic sequence stratigraphy and the responses of carbon, oxygen and strontium isotopes. The strata can be divided into three 3rd-grade sequences from Buqu Formation to 1st Member of Xueshan Formation, with \u03b413C, \u03b418O and 87Sr/86Sr changing regularly from TST to HST. The averages of \u03b413C, \u03b418O and 87Sr/86Sr are relatively high in TST and show positive characteristics on the longitudinal curve, which is opposite to things of HST in the same sequence from Buqu period to late Suowa period. The three distinct positive and negative excursions corresponded to three times of sea-floor spreading and stagnation. A few abnormal data are also analyzed in this paper.",
        "keywords": [
            "sequence stratigraphy",
            "Sr isotopes",
            "Middle-Late Jurassic",
            "C",
            "Qiangtang basin",
            "O"
        ],
        "authors": [
            {
                "name": "LIU Jianqing",
                "org": ") LI Zhengjiang2)1) Chengdu Institute of Geology and Mineral Resources, Chengdu, Sichuan "
            },
            {
                "name": "JIA Baojiang",
                "org": ") LI Zhengjiang2)1) Chengdu Institute of Geology and Mineral Resources, Chengdu, Sichuan "
            },
            {
                "name": "YANG ping",
                "org": ") LI Zhengjiang2)1) Chengdu Institute of Geology and Mineral Resources, Chengdu, Sichuan "
            },
            {
                "name": "CHEN Yulu",
                "org": " Regional Geological Surveying Party, Sichuan Bureau of Geology and Mineral Exploration, Huayang, Sichuan "
            },
            {
                "name": "PENG Bo",
                "org": " Regional Geological Surveying Party, Sichuan Bureau of Geology and Mineral Exploration, Huayang, Sichuan "
            }
        ],
        "venue": "Acta Geoscientica Sinica",
        "year": 2007
    },
    "y6jLEXPf": {
        "id": "y6jLEXPf",
        "title": "Geochemical characteristics and oil source correlation of Upper Cambrian paleo-reservoir in Xiushan",
        "abstract": "Upper Cambrian paleo-reservoir in Xiushan has an abundance of bitumens mainly occurred in intercrystalline pores,intercrystalline solution openings and stylolite of Gengjiadian Formation coarse crystalline dolomite.Total organic carbon contents are 3.43%-7.12%,indicating abundant bitumens.Influenced by leaching and oxidation of surface water and microbial degradation,the bitumens have low contents of chloroform bitumen \"A\",pyrolysis hydrocarbon and saturated hydrocarbon,high contents of aromatic hydrocarbon and non-hydrocarbon,and low ratios of \u2211C21-/\u2211C21+.The solid carbon isotopic compositions have a bimodal distribution pattern with the ranges from-26.7\u2030 to-25.6\u2030 and from-29.1\u2030 to-28.8\u2030,indicating at least two stages of oil-gas accumulation of the paleo-reservoir,and the hydrocarbons may come from different source rocks.Based on the analysis of the biomarkers,\u03b413Corg values and carbon isotopic compositions of individual n-alkanes,it is concluded that the bitumens came from the Lower Cambrian black limestone and black shale.",
        "keywords": [
            "biomarker",
            "Xiushan",
            "oil source correlation",
            "paleo-reservoir",
            "\u03b413Corg"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Chengdu Institute of Geology and Mineral Resources,Ministry of Land and Resources of the People's Republic of China,Chengdu ,China"
            },
            {
                "name": "XIE Yuan",
                "org": "Chengdu Institute of Geology and Mineral Resources,Ministry of Land and Resources of the People's Republic of China,Chengdu ,China"
            },
            {
                "name": "WANG Zheng-jiang",
                "org": "Chengdu Institute of Geology and Mineral Resources,Ministry of Land and Resources of the People's Republic of China,Chengdu ,China"
            },
            {
                "name": "LIU Jian-qing",
                "org": "Chengdu Institute of Geology and Mineral Resources,Ministry of Land and Resources of the People's Republic of China,Chengdu ,China"
            },
            {
                "name": "ZHAO Zhan",
                "org": "Chengdu Institute of Geology and Mineral Resources,Ministry of Land and Resources of the People's Republic of China,Chengdu ,China"
            },
            {
                "name": "ZHUO Jie-wen",
                "org": "Chengdu Institute of Geology and Mineral Resources,Ministry of Land and Resources of the People's Republic of China,Chengdu ,China"
            }
        ],
        "venue": "Geochimica",
        "year": 2010
    },
    "HUnapvMp": {
        "id": "HUnapvMp",
        "title": "Hydrocarbon-generating potential of the source rocks of the Sinian Doushantuo Formation on the western side of the Xuefeng Mountain",
        "abstract": "Based on systematic observation,sampling and organic geochemical studies of Sinian Doushantuo Formation source rocks on the western side of the Xuefeng Mountain,this paper summarizes source rocks distribution,organic matter types,formation of source rocks and sedimentary environment,maturity of organic matter and hydrocarbon-generation history.The platform-basin deposition model of Sinian Doushantuo Formation has a close relationship with black shale distribution and organic carbon content.The source rocks are mainly distributed in northern Guizhou,eastern Guizhou,and southeastern Upper Yangtze plate.Black shale in northern Guizhou and eastern Guizhou is from 20m to 70 m in thickness,and high-value areas of organic carbon(2.0%) are mainly distributed in northern Guizhou,eastern Guizhou,and southeastern Upper Yangtze plate such as Shimen-Taoyuan-Anhua area.Organic macerals suggest that organic matters of the black shale are of Type I.The mass fraction of group elements is characterized by saturated hydrocarbon> non-hydrocarbon > aromatic hydrocarbon.The ratio of saturated hydrocarbon and aromatic hydrocarbon in basins and slopes is generally higher than that in the restricted platform,which suggests that the black shale series of Doushantuo Formation is sapropelitic source rock and that the deposition of parent materials was somewhat related to the depositional environment throughout the depositional period.Kerogen \u03b413Corg values in different depositional environments of Doushantuo Formation imply that there existed remarkable differences in the abundances of organic matters and sources of marine plankton,maritime bacteria and marine algae.For the specific sedimentary organic matter(marine plankton,maritime bacteria and marine algae),the deeper the water,the lower the kerogen \u03b413Corg value,and the higher the organic matter content,indicating that the organic carbon content of source rocks was decided by the organic matter productivity,the formation of source rocks and the sedimentary environment.The reflectance of equivalent vitrinite(Rc) varies from 1.78% to 3.05% in the study area,and the Rc of Doushantuo Formation can be calculated by methylphenanthrene index.The Rc is 1.96% in Songlin,and from 2.06% to 2.10% in Meiziwan of Meitan,suggesting that most of the samples have reached the overmature stage,and a minor part of samples have reached the higher mature wet gas stage.The modeling results of hydrocarbon-generating history show that the source rocks of Doushantuo Formation at Zhangjiajie entered into the oil-generation stage in late early Silurian period(434 Ma),entered into the oil-generation peak stage in early Middle Triassic period(244 Ma),and entered into the condensed oil and wet oil stage in late Middle Triassic,when the Ro(%) reached 1.3.The results show that the source rocks of Doushantuo Formation were deposited in the late rift basins characterized by higher paleogeothermal gradient,lower threshold depth of oil generation and earlier oil generation,which was in favor of the accumulation of Sinian Dengying Formation oil and gas in the early time.",
        "keywords": [
            "Hydrocarbon generation history",
            "Hydrocarbon-generating potential",
            "Isotope of kerogen",
            "Sinian doushantuo formation",
            "Source rocks",
            "Western side of Xuefeng Mountain"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Chengdu Center,China Geological Survey,Chengdu ,Sichuan,China"
            },
            {
                "name": "XIE Yuan",
                "org": "Chengdu Center,China Geological Survey,Chengdu ,Sichuan,China"
            },
            {
                "name": "XuBing Li",
                "org": "China Geological Survey(China Geological Survey),Beijing,China"
            },
            {
                "name": "BAI Dao-yuan",
                "org": "Geological Survey of Hunan Province,Changsha ,Hunan,China"
            },
            {
                "name": "LIU Zao-xue",
                "org": "Geological Survey of Hubei Province,Wuhan ,Hubei,China"
            },
            {
                "name": "CHEN Hou-guo",
                "org": "Geological Survey of Guizhou Province,Guiyang ,Guizhou,China"
            }
        ],
        "venue": "Geology in China",
        "year": 2012
    },
    "exfqfrWP": {
        "id": "exfqfrWP",
        "title": "The Longeni-Angdanrco paelo-oil dolomite geochemical characteristics in southern part of the central uplift zone of Qiangtang basin and it's significance",
        "abstract": "Based on systematic analysis of lithological composition, microstructure and sedimentary facies, this paper mainly discusses the geochemical characteristics of Longeni-Angdanrco paleo-oil dolomite in southern part of the central uplift zone of Qiangtang basin. The dolomitization phenomenon mainly take place in the tidal high-energy belt, tidal-flat environment and plateau border algal head reef; the geochemical characteristics of dolomite and concomitant calcite are deeply affected by the costal and fresh water, which is identical with the previous basic judgment of climate and ancient geological conditions of blend water domitization. The fresh water effect is mainly revealed: 1 dolomite and concomitant calcite indissoluble residual indicate typical ancient humid climate; 2 Sr and Na in dolomite and concomitant calcite is similar to that of fresh water calcite in Missouri and Tennessee of U. S.; 3 microelement B, Sr/Ba value and Sr/Ca value, and main element m Fe/Mn value of dolomite and concomitant calcite refect that the carbonate was formed in the costal carbonate plateau environment, and dolomite and concomitant calcite are deeply affected by the fresh water. Except Sr, the dolomitization in the study area has obvious output phenomenon, while Na and K have obvious input phenomenon, and most elements remain the original characteristics of compostion.",
        "keywords": [
            "Dolomite",
            "Fresh water effect",
            "Geochemistry",
            "Qiangtang basin"
        ],
        "authors": [
            {
                "name": "Jianqing Liu",
                "org": "Chengdu Institute of Geology and Mineral Resources(Chengdu Institute of Geology and Mineral Resources,Chengdu College of Geology,Chengdu Institute of Meteorology),Chengdu,China"
            },
            {
                "name": "WenBing B. Chen",
                "org": "Chengdu Institute of Geology and Mineral Resources(Chengdu Institute of Geology and Mineral Resources,Chengdu College of Geology,Chengdu Institute of Meteorology),Chengdu,China"
            },
            {
                "name": "Ping Yang",
                "org": "Chengdu Institute of Geology and Mineral Resources(Chengdu Institute of Geology and Mineral Resources,Chengdu College of Geology,Chengdu Institute of Meteorology),Chengdu,China"
            },
            {
                "name": "Wenxi Chen",
                "org": "Chengdu Institute of Geology and Mineral Resources(Chengdu Institute of Geology and Mineral Resources,Chengdu College of Geology,Chengdu Institute of Meteorology),Chengdu,China"
            },
            {
                "name": "Xiugen Fu",
                "org": "Chengdu Institute of Geology and Mineral Resources(Chengdu Institute of Geology and Mineral Resources,Chengdu College of Geology,Chengdu Institute of Meteorology),Chengdu,China"
            }
        ],
        "venue": "Acta Petrologica Sinica",
        "year": 2008
    },
    "JxjXENOx": {
        "id": "JxjXENOx",
        "title": "An approach to the oil and gas exploration potential in the marine strata in the western part of the Xuefeng Mountains,southern China",
        "abstract": "The examination of stacking patterns,sedimentary sequences,sequence stratigraphy and cyclic deposition in the western part of the Xuefeng Mountains,southern China shows that just like the Sichuan Basin,the western part of the Xuefeng Mountains has gone through the basin evolution from the passive continental margin(Z-O1) through the forelandoid basin(O2-S) to the craton-continental marginal basin(D-T2) and the inland lake basin(T2-J),and finally to the intermountain basin(K-Q).Nine reginal parallel unconformities and one angular unconformity are observed,constituting five tectonic terranes,including: \u2460 the Nanhuan to the Sinian;\u2461 the Lower Palaeozoic;\u2462 the Upper Palaeozoic to the Lower-Middle Triassic;\u2463 the Upper Triassic to the Lower-Middle Jurassic,and \u2464 the Upper Cretaceous or younger.In the above-mentioned tectonic terranes,there occur four first-order source-reservoir-seal associations,of which Associations I and II are believed to be favourable.The study area was originally in the favourable geological conditions,but there after underwent severe tectonic modification,especially the mountain building,uplifting and denudation from the Yanshanian movement at the end of the Jurassic onwards.It follows that the tectonic modification cited above are considered as the controlling factors of the oil and gas exploration in the marine lower association in the study area.",
        "keywords": [
            "sequence stratigraphy",
            "western part of the Xuefeng Mountains",
            "sedimentary and tectonic evolution",
            "source-reservoir-seal association",
            "marine lower association"
        ],
        "authors": [
            {
                "name": "ZHUO Jie-wen",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China;Graduate School,Chinese Academy of Geological Sciences,Beijing ,China"
            },
            {
                "name": "WANG Zheng-jiang",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            },
            {
                "name": "WANG Jian",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            },
            {
                "name": "XIE Yuan",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            },
            {
                "name": "YANG Ping",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            },
            {
                "name": "LIU Jian-qing",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            },
            {
                "name": "ZHAO Zhan",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            }
        ],
        "venue": "Sedimentary Geology and Tethyan Geology",
        "year": 2009
    },
    "qYdvk9h4": {
        "id": "qYdvk9h4",
        "title": "The characteristics of Longeni-Angdaercuo paleo-oil dolomite in southern part of the central uplift zone of Qiangtang Basin and its forming mechanism",
        "abstract": "Based on the field survey,we have conducted a series of research on the Longeni-Angdaercuo paleo-oil dolomite in southern part of Qiangtang Basin central uplift zone,including its mineral and crystal characteristics,lithological composition,sedimentary facies,fluid inclusion,carbon and oxygen isotope. The microstructures of dolomite consist of four types:remnant ooid structure,fogged center and clear margin structure,ring structure and generation growth texture. The dolomitization mainly took place in plateau border shallow water belt,tidal-flat and plateau border algal reef. The degree of ordering of dolomite is generally higher. The value of \u03b413C and \u03b418O is higher than that of the concomitant calcite; the calculated salinity of fluid in dolomite at the time of its formation is higher than that of the sea water; and the temperature in dolomitization area deduced by the isotopic value is higher than that of the earth surface. The fluid inclusions are few and small in dolomite,mainly obtained from calcite vein; there are two homogenization temperature intervals that correspond to the two tectonism and oil migrations. The dolomitization occurred before the oil migration. All of the information mentioned above suggests that the dolomite in this area should be the result of mixed water replacement of calcite.",
        "keywords": [
            "dolomite",
            "Qiangtang Basin",
            "mixwater replacement"
        ],
        "authors": [
            {
                "name": "Liu Jianqing",
                "org": " Chengdu Institute of Geology and Mineral Resources,Chengdu ,China"
            },
            {
                "name": "Yang Ping",
                "org": " Chengdu Institute of Geology and Mineral Resources,Chengdu ,China"
            },
            {
                "name": "Chen Wenbin",
                "org": " Chengdu Institute of Geology and Mineral Resources,Chengdu ,China"
            },
            {
                "name": "Chen Wenxi",
                "org": " Chengdu Institute of Geology and Mineral Resources,Chengdu ,China"
            },
            {
                "name": "Fu Xiugen",
                "org": " Chengdu Institute of Geology and Mineral Resources,Chengdu ,China"
            }
        ],
        "venue": "Earth Science Frontiers",
        "year": 2010
    },
    "L4j5Kg0F": {
        "id": "L4j5Kg0F",
        "title": "REE geochemical signatures and sedimentary environments of the Lower Cambrian black rock series in southeastern Chongqing and its adjacent areas",
        "abstract": "The Lower Cambrian black rock series in southeastern Chongqing and its adjacent areas are characterized by less-enriched \u03a3REE,\u03a3LREE/\u03a3HREE ratios ranging between 1.99 and 9.01 with an average of 6.86,relatively Enriched LREE,\u03b4Eu values ranging between 0.69 and 7.33 with an average of 2.79,and \u03b4Ce values ranging between 0.70 and 1.01 with an average of 0.85.The results of research in the present paper show that the Lower Cambrian black rock series in the study area resulted from the mixing of the normal seawater and hot seawater deposition in the transitional conditions from the anoxic reducing environments to the weakly oxidized environments on the outer continental shelves.",
        "keywords": [
            "black rock series",
            "southeastern Chongqing",
            "sedimentary environment",
            "REE"
        ],
        "authors": [
            {
                "name": "ZHAN Z",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            },
            {
                "name": "XIE Yuan",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            },
            {
                "name": "LIU Jian-qing",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            },
            {
                "name": "QIU Dong-zhou",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            },
            {
                "name": "YANG Ping",
                "org": "Chengdu Institute of Geology and Mineral Resources,Chengdu ,Sichuan,China"
            }
        ],
        "venue": "Sedimentary Geology and Tethyan Geology",
        "year": 2011
    },
    "KePGYegE": {
        "id": "KePGYegE",
        "title": "ANALYSIS OF SUREM AFP\u3001CEA AND CA199 OF 1033 OCCUPATIONAL DISEASE STAFFS",
        "abstract": "[Objective]To discuss AFP,CEA and CA199 change in every age group of occupational disease staffs.[Methods]serum AFP,CEA and CA199 of 1 033 occupational disease staff members were examined by glowing immune electrochemistry analysis.The regularity in different sex and age groups was described.[Results]There was significant difference in CEA between male and female(P = 0.000).There were significant differences in CEA(P=0.009)and AFP(P=0.000)among every age group.Along with age increasing,AFP\u3001CEA and CA199 all showed regular changes.[Conclusion]In 20-49 age group,AFP\u3001CEA increase with ages,but decrease after 50 years old.In 20-39 age group,CA199 increase with age.There is a decrease of CA199 in 40-49 age group,but increase after 50.We ought to pay more attention to the detection of tumor markers in occupational disease staffs aged between 40 and 50 to prevent the incidence of malignant disease and set up the normal reference values by sex and age.",
        "keywords": [
            "CA199",
            "AFP",
            "CEA"
        ],
        "authors": [
            {
                "name": "FANG Kun",
                "org": "Clinical laboratory,Hospital Scientific Cigy,Mianyang ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Clinical laboratory,Hospital Scientific Cigy,Mianyang ,China"
            }
        ],
        "venue": "Modern Preventive Medicine",
        "year": 2007
    },
    "ruTfBeXb": {
        "id": "ruTfBeXb",
        "title": "Effect of Blood Lipids and Age on Platelet Parameters and Its Correlation Analysis",
        "abstract": "[Objective]To investigate the influence of lipid and age on the blood platelet parameter.[Methods]The fasting serum cholesterol(TC),triglyceride(TG) content and whole blood platelet(PLT)parameters detection was performed on 5 315 subjects(aged 19 to 86 years).SPSS software was applied to analyze the relationship between blood lipid,age and platelet parameters.[Results]Platelet count(PLT) was negatively correlated with age(P<0.01);MPV increased with age at first and then decreased.In elderly people(>50 years),PLT was positively correlated with lipid and negatively correlated with age(P<0.01);the impact of dyslipidemia on the MPV was not obvious(P>0.05).There was weak correlation between lipids(especially TC) and PLT,MPV(P<0.01)[Conclusion]Aging,high blood cholesterol(especially the abnormal increase of TC) are closely related to PLT and MPV.PLT activity can be observed by dynamic monitoring the changes of PLT parameters.PLT was increased in the older people with TC exceptionally-increasing.Therefore,the lipid-lowering treatment should be combined with anti-PLT therapy at the same time.",
        "keywords": [
            "Lipid",
            "Cardiovascular diseases",
            "Platelet count",
            "Mean platelet volume"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Science City Hospital,Sichuan,,China"
            },
            {
                "name": "FANG Kun",
                "org": "Science City Hospital,Sichuan,,China"
            },
            {
                "name": "ZHANG Li-ping",
                "org": "Science City Hospital,Sichuan,,China"
            },
            {
                "name": "JIA Juan",
                "org": "Science City Hospital,Sichuan,,China"
            }
        ],
        "venue": "Occupation and Health",
        "year": 2011
    },
    "C6bKaiHI": {
        "id": "C6bKaiHI",
        "title": "THE DETECTION OF GLUCOSE,BLOOD LIPID,URIC ACID IN 10502 HEALTHY PERSONS.",
        "abstract": "Objective:To study the levels of fasting serum glucose(GLU),total cholesterol(TC),triglyceride(TG) and uric acid(UA) in adult.Methods:The levels of fasting TC,TG and UA of 10502 adults were measured enzymatically and fasting glucose level was measured by electrode.Results:The level of GLU,the ratios of impaired fasting glucose(IFG) and the positive rate of diabetes were significant difference among all age groups.The levels of TC and TG were increased significantly with age in those younger than 50-year-old(P<0.05),but no same change was found in those older than 50-year-old.The ratio of hypercholesterolemia was also increased significantly with age in those younger than 50-year-old(P<0.05),but no significant change was found in those older than 50-year-old.The ratio of hypertriglyceridemia was increased significantly with age in younger than 40-year-old groups(P<0.05),but no same change was found in groups older than 40-year-old except the group of 60-70 years old.The level and ratio of hyperuricemia was found significant higher in group \u226570-year-old(374.743\u00b188.831 \u03bcmol/L\u300128.3%),(P<0.05).Meanwhile the levels of UA in male were much higher in the groups of 30-49 years old(376.208\u00b168.818 \u03bcmol/L) than other groups except \u226570-year-old group(387.638\u00b187.838 \u03bcmol/L).All examined results of all groups including the ratios of hypercholesterolemia,hypertriglyceridemia,and hyperuricemia were all found higher in male than that in female.Conclusion: The ratios of IFG,diabetes incidence and hyperlipidaemia incidence were increased with age.And the level of UA in male was also high at the age of 30 to 49.The ratios of hyperlipidaemia and hyperuricemia were much higher in mature male and menopause female.",
        "keywords": [
            "Triglyceride",
            "Glucose",
            "Cholesterol",
            "Uric acid"
        ],
        "authors": [
            {
                "name": "ZHANG Li-ping",
                "org": ",et al.Science City Hospital of Sichuan Province,Mianyan,."
            },
            {
                "name": "LI Feng-hua",
                "org": ",et al.Science City Hospital of Sichuan Province,Mianyan,."
            },
            {
                "name": "YANG Ping",
                "org": ",et al.Science City Hospital of Sichuan Province,Mianyan,."
            }
        ],
        "venue": "Modern Preventive Medicine",
        "year": 2006
    },
    "pGUoXgA6": {
        "id": "pGUoXgA6",
        "title": "THE COMPARISON OF 12 152 WORKER\u2019S RBC PARAMETERS",
        "abstract": "[Objective] To investigate prevalence of anemia and erythrocytosis. [Methods] The blood specimen of health examinations of 12 152 cases were analyzed by Beckman coulter 5 Diff hematology analyzer. [Results] RBC, HGB and HCT in those younger than 50-year-old groups were significantly higher than those in other groups (P\ufe640.05). RBC, HGB and HCT in females were lower in the groups of 30-49 years old than those in other groups, but much higher in those older than 50-year-old (P\ufe640.05). The prevalence of anemia significantly increased in those older than 60 (P\ufe640.05), and the prevalence of erythrocytosis in males was higher than in females (P\ufe640.05) except in the group of 30-39 years old, which mainly existed in the groups of 40-59 years old males and older than 60-year-old females; non-anemia small cell erythrocytosis in the group of older than 70-year-old was significantly lower than that of other groups (P\ufe640.01). [Conclusion] The prevalence of anemia may be high in 30 to 49 years old women, and thrombotic diseases may likely occur among 40-59 years old men.",
        "keywords": [
            "Erythrocytosis",
            "Anemia",
            "RBC parameters"
        ],
        "authors": [
            {
                "name": "ZHANG Li-ping",
                "org": "Science City Hospital in Sichuan Province, Chengdu , China"
            },
            {
                "name": "YANG Ping",
                "org": "Science City Hospital in Sichuan Province, Chengdu , China"
            },
            {
                "name": "LI Feng-hua",
                "org": "Science City Hospital in Sichuan Province, Chengdu , China"
            }
        ],
        "venue": "Modern Preventive Medicine",
        "year": 2010
    },
    "z8OzkUo5": {
        "id": "z8OzkUo5",
        "title": "Influence of temperature and storage time on reticulocyte parameters and establishment of reference values for laboratory parameters",
        "abstract": "[Objective]To study the influence on temperature and storage time on reticulocyte parameters,establish the reference range.[Methods]The specimens were stored at different temperature for different time,as so to observe the variations of reticulocyte parameters.[Results]Under the condition of low temperature(2-8 \u2103),the reticulocyte count(Ret%),reticulocyte absolute value,high laser reticulocyte percentage(HLR%),high laser reticulocyte absolute value,immature reticulocyte fraction(IRF) and mean spherical corpuscular volume(MSCW) had not changed within 72 hours(P > 0.05).Under the condition of room temperature(18-25 \u2103),except that IRF had no obvious change within 48 hours,other parameters had changed significantly after 24 hours(P < 0.05).The reference range from statistical results was wider than the setting reference range,but the pathological low limit was basically the same.[Conclusion]Reticulocyte specimens should be stored in low temperature(2-8 \u2103),and the determination should be completed within 48 hours.",
        "keywords": [
            "Reticulocyte parameters",
            "Reticulocyte maturity"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": " Laboratory Department,Science City Hospital of Sichuan,Mianyang,,China"
            },
            {
                "name": "JIA Juan",
                "org": " Laboratory Department,Science City Hospital of Sichuan,Mianyang,,China"
            },
            {
                "name": "LI Gui-cai",
                "org": " Laboratory Department,Science City Hospital of Sichuan,Mianyang,,China"
            },
            {
                "name": "ZHANG Li-ping",
                "org": " Laboratory Department,Science City Hospital of Sichuan,Mianyang,,China"
            },
            {
                "name": "JIANG Xing",
                "org": " Laboratory Department,Science City Hospital of Sichuan,Mianyang,,China"
            }
        ],
        "venue": "Occupation and Health",
        "year": 2013
    },
    "lMtyGYsM": {
        "id": "lMtyGYsM",
        "title": "Optimum Layout of Irregular Unbended Sheet Metal Part Based on Pro/E",
        "abstract": "The genetic algorithms and the computer aided optimum layout for irregular shape unbended sheet metal part based on Pro/E are introduced.The process of building the goal function and the operation of coding and nesting in genetic algorithms is researched.The method of optimum layout for irregular shape unbended sheet metal part based on Pro/E by using genetic algorithms is found.",
        "keywords": [
            "genetic algorithm",
            "optimum layout",
            "irregular shape unbended sheet metal part"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Lanzhou University of Technology,Lanzhou ,China"
            },
            {
                "name": "YANG Chuanhua",
                "org": "Lanzhou University of Technology,Lanzhou ,China;Jiamusi University,Jiamusi ,China"
            },
            {
                "name": "TANG Yan",
                "org": "Shuangfa Shiye CO.LTD,Puyang ,China"
            },
            {
                "name": "ZHOU Meiyan",
                "org": "Lanzhou University of Technology,Lanzhou ,China"
            }
        ],
        "venue": "Machinery & Electronics",
        "year": 2006
    },
    "DpPfEDVZ": {
        "id": "DpPfEDVZ",
        "title": "Portal crane structural reliability optimal allocation based on maximum entropy ordered weighted average method",
        "abstract": "The paper introduces the application of the maximum entropy ordered weighted average allocation in the portal crane which effectively solves the shortcomings of traditional methods and leaves out the pre-estimate of reliability.The results show that the method is not only accurate and effective,but also can get the best distribution result of the failure rate,thus to achieve the optimal reliability allocation of portal crane structure,and provide an important basis for the rational design of the portal crane.",
        "keywords": [
            "reliability allocation",
            "metal structure",
            "portal crane",
            "ME-OWA",
            "weighted average method"
        ],
        "authors": [
            {
                "name": "Gao Lihong",
                "org": ""
            },
            {
                "name": "Xu Gening",
                "org": ""
            },
            {
                "name": "Yang Ping",
                "org": ""
            }
        ],
        "venue": "Hoisting and Conveying Machinery",
        "year": 2011
    },
    "3ovv2NvC": {
        "id": "3ovv2NvC",
        "title": "The Research of Model Data Conversion in Virtual Assembly System",
        "abstract": "Aiming at the model data conversion problem in virtual assembly system,in order to integrate the model from CAD system to virtual assembly system,a method is proposed that can convert the part information into information classification,the model consists of the assembly object information,object level information,assembly object relationship information,and patch information.Though the second development of CAD system and CAD model conversion interface with its own,we can get the necessary parts of virtual assembly system model data.",
        "keywords": [
            "virtual assembly second development classification conversion assembly model"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Lanzhou University of Technology,College of Mechanical &Electrical Engineering,Lanzhou ,P.R.China"
            },
            {
                "name": "LI Lei-lei",
                "org": "Lanzhou University of Technology,College of Mechanical &Electrical Engineering,Lanzhou ,P.R.China"
            }
        ],
        "venue": "Science Technology and Engineering",
        "year": 2011
    },
    "AH9LFaDm": {
        "id": "AH9LFaDm",
        "title": "Application of non-probabilistic reliability based on interval interference model",
        "abstract": "The non-probabilistic method was proposed according to the distribution pattern of uncertain parameters inaccurately acquired from the reliability analysis.Interval model was used to describe the uncertain parameters,and based on non-probabilistic set-based stress-strength interference theory,the non-probabilistic reliability index was studied under different conditions.Meanwhile the reliability index under probabilistic model of a propeller shaft was compared with that of interval model and the changes of the non-probabilistic reliability were also observed with different deviation of the uncertain parameters.The result shows that when the outer diameter of the propeller shaft is 50 mm the structure was reliable under probabilistic model and interval model,but when the outer diameter is 48 mm the probabilistic and non-probabilistic reliabilities were 0.999 803 and 0.982 110,respectively.Therefore,conclusions were consistent under probabilistic and interval models,but the non-probabilistic method was more conservative.Meanwhile with increase of deviation for the uncertain parameters,the non-probabilistic reliability of propeller shaft gradually reduced.Therefore,the strength of deviation is the main factor affecting non-probabilistic reliability,while the torque of deviation is the least.Consequently the reliability of propeller shaft increased with the increase of the thickness and decrease of the deviation of uncertain parameters.The method of non-probabilistic reliability analysis was feasible.",
        "keywords": [
            "interval model",
            "uncertain parameter",
            "non-probabilistic reliability",
            "reliability"
        ],
        "authors": [
            {
                "name": "LIU Xiao",
                "org": "School of Mechanic and Electronic Engineering,Lanzhou University of Technology,Lanzhou,Gansu ,China, 2.Department of Mechanic Engineering,Taiyuan Institute of Technology,Taiyuan,Shanxi ,China"
            },
            {
                "name": "XU Ge-ning",
                "org": "Electromechanical Institute,Taiyuan University of Science & Technology,Taiyuan,Shanxi ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Mechanic and Electronic Engineering,Lanzhou University of Technology,Lanzhou,Gansu ,China, 2.Department of Mechanic Engineering,Taiyuan Institute of Technology,Taiyuan,Shanxi ,China"
            }
        ],
        "venue": "Journal of China University of Mining & Technology",
        "year": 2012
    },
    "Y2L2Qp0z": {
        "id": "Y2L2Qp0z",
        "title": "Research on ANN-based Reliability Analysis of Complex Structures",
        "abstract": "Integer structure was divided into some module structures according to topological connection.Comparing with integer structure,module structure was easily analyzed because of briefness structure,and the computation speed was improved.Module structure was computed on element stiffness matrix based on load transfer behavior and displacement compatibility conditions.Integer structure was computed on node balanced equation.Thus information of module structure was gained.Module structure information was considered as input data and integer structure information was considered as output data.Thus specimen was built on input data and output data.Using the nonlinear mapping capability,neural network structure with interpolation and extrapolation was gained by training specimen.So integer structure recomputed can be replaced by module structure computed.Rules of correspondence between integer structure and module structure under equivalent load were built on integer structure with six module structures as an instance.Integer structure with eight module structures was analyzed by neural network extrapolation.Integer structure with four module structures was analyzed by neural network interpolation.All of designs have perfect computing precision contrasting with optimization criteria.",
        "keywords": [
            "neural network",
            "module structure",
            "failure mode analysis",
            "integer structure"
        ],
        "authors": [
            {
                "name": "Wang Aihong",
                "org": "Lanzhou University of Technology,Lanzhou,;Taiyuan University of Science and Technology,Taiyuan,"
            },
            {
                "name": "Xu Gening",
                "org": "Taiyuan University of Science and Technology,Taiyuan,"
            },
            {
                "name": "Yang Ping",
                "org": "Lanzhou University of Technology,Lanzhou,"
            },
            {
                "name": "Gao Youshan",
                "org": "Taiyuan University of Science and Technology,Taiyuan,"
            }
        ],
        "venue": "China Mechanical Engineering",
        "year": 2008
    },
    "x9G09nzq": {
        "id": "x9G09nzq",
        "title": "Research in Geometric Tolerance of GB Based on Pro/Toolkit Secondary Development",
        "abstract": "The method by means of Dynamic Link Library to mark a geometric tolerances on drawing according to the needs of the customers,under Pro/E Wildfire 4.0 condition utilizing the technology of VC+ +.Net and the secondary developmental tool\u2014\u2014Pro/Toolkit has been introduced in the paper.The key techniques to develop the menu and the dialog box of MFC also have been discussed and a simple plug-in of geometric tolerance according to Chinese standard have been obtained.",
        "keywords": [
            "Pro/Toolkit",
            "secondary development",
            "VC+ +",
            "geometric tolerance",
            "annotating system of GB"
        ],
        "authors": [
            {
                "name": "Yang Ping",
                "org": " ,Professor,School of Mechanical and Electrical Engineering,Lanzhou University of Technology,Lanzhou ,China"
            },
            {
                "name": "Zhang Mingliang",
                "org": " ,Professor,School of Mechanical and Electrical Engineering,Lanzhou University of Technology,Lanzhou ,China"
            }
        ],
        "venue": "Tool Engineering",
        "year": 2012
    },
    "KX7d5a0y": {
        "id": "KX7d5a0y",
        "title": "Technology of SolidWorks Redevelopment with Visual C++",
        "abstract": "The method of secondary development of solidworks using Microsoft access and Visual C++ is presented. The techniques and methods by examples are discussed in detail. It has some practical value to SolidWorks for engineering application of corporation.",
        "keywords": [
            "SolidWorks",
            "Visual C++",
            "database"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "College of Electrical and Mechanical Engineering,Lanzhou University of Technology,Lanzhou ,China"
            },
            {
                "name": "XU Xingzhi",
                "org": "College of Electrical and Mechanical Engineering,Lanzhou University of Technology,Lanzhou ,China"
            }
        ],
        "venue": "New Technology & New Process",
        "year": 2008
    },
    "Cgf1c1cx": {
        "id": "Cgf1c1cx",
        "title": "The Application of CAD/CAM on Brick-carving Design and Process",
        "abstract": "The principle of the brick-carving process based on CAD/CAM was introduced,the feasibility of mechanical carving brick aided by computer computer-aided was analyzed from the processing technology and processing methods.By comparing computer assisted mechanical carving with handiwork carving,the feasibility of applying CAD / CAM technology in the brick-carving technology was discussed from broadening material design,enhancing the artistic effect,raising productivity and reducing labor intensity and so on.",
        "keywords": [
            "CAD/CAM",
            "Mechanical computer-aided carve",
            "Brick-carving"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "College of Mechanical & Electronical Engineering,Lanzhou University of Technology,Lanzhou Gansu ,China"
            },
            {
                "name": "WANG Jianli",
                "org": "College of Mechanical & Electronical Engineering,Lanzhou University of Technology,Lanzhou Gansu ,China"
            },
            {
                "name": "YIN Yanjun",
                "org": "College of Mechanical & Electronical Engineering,Lanzhou University of Technology,Lanzhou Gansu ,China"
            }
        ],
        "venue": "Machine Tool & Hydraulics",
        "year": 2009
    },
    "r2IZ3sfM": {
        "id": "r2IZ3sfM",
        "title": "The Pro/TOOLKIT Program Design of the Sheet Metal Parts\u2032 Drawing Automatic Generation",
        "abstract": "The paper presents the method on the re-development technology of Pro/ENGINEER in detail, explaining the theory of the Sheet Metal Parts\u2032 Drawing Automatic generation and how to create the menu, MFC dialog boxes and drawing\u2019s sheetpage. So, the sheet metal parts\u2032 drawings are achieved by changing parameters in the MFC dialog boxes and without modifying the original program codes.",
        "keywords": [
            "Pro/TOOLKIT",
            "Application Re-development",
            "Pro/ENGINEER",
            "Drawing"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Lanzhou University of Technology, Lanzhou, CHN"
            },
            {
                "name": "ZHOU Meiyan",
                "org": "Lanzhou University of Technology, Lanzhou, CHN"
            },
            {
                "name": "HAN Fei",
                "org": "Lanzhou University of Technology, Lanzhou, CHN;Qingdao Hongda Textile Machinery Co.,Ltd., Qingdao , CHN"
            }
        ],
        "venue": "Manufacturing Technology & Machine Tool",
        "year": 2006
    },
    "krCs0BhL": {
        "id": "krCs0BhL",
        "title": "Construction of recombinant adenovirus expression vector of Ad5F11p-miR29c and evaluation of its pro-apoptotic effects on myeloma cells",
        "abstract": "Objective The aim of this study is to construct a recombinant adenovirus expression vector of Ad5F11p-miR29c and to evaluate its pro-apoptotic effects on myeloma cells.Methods Nest-PCR was applied to get the gene of hsa-miR29c.Then the hsa-miR29c gene was inserted into the pShuttle vector.The resulted pshuttle vector pShuttle-CMV-miR29c was linearied by PmeI,followed by electric transformation into BJ5183 cells containing Ad5F11p,resulting in a recombined adenovirus vector by.The recombined adenovirus vector was linearied by PacI,and then was transfected into HEK293 cells to get Ad5F11p-miR29c.The adenovirus was packaged and produced 8~12 days after transfection and confirmed by PCR.The optimal MOI was detected by flow cytometry using Ad5F11p-EGFP in multiple myeloma cell lines(SKO-007,U266,and XG7).Flow cytometry was also applied to test the Adenovirus-mediated proapoptotic effects in human multiple myeloma cell lines.Results miR29c gene was obtained by Nest-PCR and ligated into pShuttle-CMV.Recombined adenovirus Ad5F11p-miR29 was successfully constructed using Ad5F11p system,in which the miR29c gene expression was regulated by CMV.Flow cytometry results showed that the optimal MOI in SKO-007 and U266 were both 150,while in XG7 was 100.After 48 h infection of Ad5F11p-miR29c with the optimized MOI,the percentage of apoptotic cells was increased in SKO-007 and XG7 cells.Conclusions We successfully constructed the recombinant adenovirus expression vector Ad5F11p-miR29c and demonstrated that miR29c can induce apoptosis in human myeloma cells.",
        "keywords": [
            "Gene expression",
            "Adenoviridae",
            "Apoptosis",
            "MicroRNAs",
            "Multiple myeloma",
            "Plasmids"
        ],
        "authors": [
            {
                "name": "ZHANG Yi-kun",
                "org": ""
            },
            {
                "name": "WANG Hua",
                "org": ""
            },
            {
                "name": "YANG Ping",
                "org": ""
            },
            {
                "name": "LI Ze-liang",
                "org": ""
            },
            {
                "name": "YANG Yue-feng",
                "org": ""
            },
            {
                "name": "CHEN Xie-qun",
                "org": ""
            },
            {
                "name": "WANG Li-sheng",
                "org": ""
            }
        ],
        "venue": "Chinese Medicinal Biotechnology",
        "year": 2012
    },
    "211HuUNM": {
        "id": "211HuUNM",
        "title": "Structure Light 3D Surface Reconstruction",
        "abstract": "A kind of curved surface reconstruction method according to the structure light 3D stereovision is proposed. The calibration of the camera and the flat surface has been discussed. The structured light stripe which was modulated by the object surface is used as the object 3D information transfer instrument. A charge coupled device camera is used to obtain images which are analyzed by the software. The raster stripe which have been modulated is decoded. Finally, through modulated system the object\u2019s 3D curved surface data is obgtained.",
        "keywords": [
            "structure light 3D surface profile calibration profile measurement"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "College of Mechano-Electronic Engineering, Lanzhou University of Technology,Lanzhou "
            },
            {
                "name": "TANG Yazhe",
                "org": "College of Mechano-Electronic Engineering, Lanzhou University of Technology,Lanzhou "
            }
        ],
        "venue": "Science Technology and Engineering",
        "year": 2006
    },
    "qgXiTRFc": {
        "id": "qgXiTRFc",
        "title": "Research on game strategies of robots' racing competition",
        "abstract": "This paper applies the game theory in the robots' competition through researching it.The strategy selection of the robot competition is analyzed from the perspective of game theory.By using the game model of \"Tian Ji Horse Racing\" for robots modeling,the optimal solution was found and result was analyzed.",
        "keywords": [
            "mobile robot",
            "pay off",
            "strategy",
            "decision making",
            "game theory"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "College of Mechanical and Electronic Engineering,Lanzhou University of Technology,Lanzhou ,China"
            },
            {
                "name": "SHI Xiao-xing",
                "org": "College of Mechanical and Electronic Engineering,Lanzhou University of Technology,Lanzhou ,China"
            },
            {
                "name": "LI Yao",
                "org": "College of Mechanical and Electronic Engineering,Lanzhou University of Technology,Lanzhou ,China"
            }
        ],
        "venue": "Journal of Machine Design",
        "year": 2011
    },
    "sDfvmndw": {
        "id": "sDfvmndw",
        "title": "BRIDGE CRANE LOAD DISTRIBUTION FITTING AND TEST",
        "abstract": "In order to obtain the actual load distribution model of the bridge crane,lifted load sample was collected for five days in a shop for a 75/30 t bridge crane,and collected sample size was 165.The sample was tested separately with supremum statistic(D statistic) and square variance statistic(A2 statistic,W2 statistic).Six hypothesis distribution models were exponential distribution,normal distribution,logarithmic normal distribution,Gamma distribution,two parameter Weibull distribution,three parameter Weibull distribution.The results show that distribution model hypotheses,distribution testing methods,significance levels all impact the testing results.Three-parameter Weibull distribution fits the bridge crane loads best compared with the other distribution models.The tested result is the antecedent of fatigue analysis,life appraisal study,and reliability computing for crane steel structure.",
        "keywords": [
            "Bridge crane",
            "Distribution fitting",
            "Likelihood ratio test",
            "Load distribution",
            "Statistics testing"
        ],
        "authors": [
            {
                "name": "WANG AiHong",
                "org": "College of Mechanical Electronic Engineering,Lanzhou University of Technology,Lanzhou ,China;College of Mechanical Electronic Engineering,Taiyuan University of Science and Technology,Taiyuan ,China"
            },
            {
                "name": "XU GeNing",
                "org": "College of Mechanical Electronic Engineering,Taiyuan University of Science and Technology,Taiyuan ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Mechanical Electronic Engineering,Lanzhou University of Technology,Lanzhou ,China"
            },
            {
                "name": "GAO YouShan",
                "org": "College of Mechanical Electronic Engineering,Taiyuan University of Science and Technology,Taiyuan ,China"
            }
        ],
        "venue": "Journal of Mechanical Strength",
        "year": 2011
    },
    "MXXB3YLv": {
        "id": "MXXB3YLv",
        "title": "Design and Application of the Temperature Rise Experiments System with Virtual Instrumentation",
        "abstract": "There are various appliances experiments,such as the experiment under medium or high pressure and the factory inspection.The temperature rise experiment,the machine life span experiment,the thunder and lightning pounds experiment and so on are the typical appliance experiments.Whether the data from these experiments accurate or not is very important to the qualified and safe of the products.In this thesis,a data collection system is designed with a software for invented instrument and the PCI-6221 data collection card from NI corporation.In system design process,because of the application of the graphical programming software and the data collection card,the time for the system to set up is saved,the collection efficiency is improved,the artificial mistake can be avoided.",
        "keywords": [
            "Automatic stable electric current",
            "Virtual instrument",
            "Temperature-rise"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "College of Mechanical&Electronical Engineering,Lanzhou University of Technology,Lanzhou ,China"
            },
            {
                "name": "ZHANG Zong",
                "org": "College of Mechanical&Electronical Engineering,Lanzhou University of Technology,Lanzhou ,China"
            }
        ],
        "venue": "New Technology & New Process",
        "year": 2009
    },
    "uMrxFcuV": {
        "id": "uMrxFcuV",
        "title": "Non-probabilistic reliability analysis of cutter shaft in rotary tiller based on interval model",
        "abstract": "In order to solve the intensive dependence of the probabilistic reliability and fuzzy reliability on the original data,the reliability of cutter shaft was analyzed by using the theory of non-probabilistic reliability based on the interval model for describing the uncertain parameter of the cutter shaft.The measure of non-probabilistic reliability was presented where the minimum distance between the upper limit of failure domain and the lower limit of reliability domain was used for this measure and the original definition of non-probabilistic reliability was taken into consideration.It was verified by analysis of two design schemes of the cutter shaft that the result of this method was consistent with that by using the original definition of the non-probabilistic reliability.",
        "keywords": [
            "interval model",
            "cutter shaft",
            "uncertain parameter",
            "non-probabilistic reliability"
        ],
        "authors": [
            {
                "name": "LIU Xiao",
                "org": "College of Mechano-Electronic Engineering,Lanzhou Univ.of Tech.,Lanzhou ,China;Department of Mechanic Engineering,Taiyuan Institute of Technology,Taiyuan ,China"
            },
            {
                "name": "XU Ge-ning",
                "org": "Electromechanical Institute,Taiyuan University of Science & Technology,Taiyuan ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Mechano-Electronic Engineering,Lanzhou Univ.of Tech.,Lanzhou ,China"
            }
        ],
        "venue": "Journal of Lanzhou University of Technology",
        "year": 2012
    },
    "B267bsmE": {
        "id": "B267bsmE",
        "title": "Design of the Vehicle Box of In-pipe Clearing Ash Robot",
        "abstract": "According to the concrete conditions of the pipeline,the work environment of the clearing ash robot in exhaust gas pipeline of metal smeltery and the require of cleaning ashes,the structure of in-pipe clearing ash robot was designed.The vehicle box was designed on the robotic structure.Based the principle of the dead point of the mechanism,the purpose in clear ashes automatically was realized by using the electric motor and worm-and-wheel gear to control vehicle box.",
        "keywords": [
            "In-pipe clearing ash robot",
            "Worm-and-wheel gear",
            "Vehicle box"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "College of Mechano-electronic Engineering,Lanzhou Univ.of Tech.,Lanzhou ,China"
            },
            {
                "name": "WANG Chong",
                "org": "College of Mechano-electronic Engineering,Lanzhou Univ.of Tech.,Lanzhou ,China"
            }
        ],
        "venue": "Machine Tool & Hydraulics",
        "year": 2007
    },
    "NhQlYcWM": {
        "id": "NhQlYcWM",
        "title": "Simulation of Molding and Mold Opening for Mold Shaping Part Based on Pro/E",
        "abstract": "Traditional mold designers usually depend on their intuition and experience.Mould is always debug and corrected again and again before it can be used in production.The mold design cycle is long and the cost is high.Simulation of molding and mold opening by Pro/E software can help testify the reasonability of mold shaping part designing,it can also shorten the period of mould design and lower the product cost.Taking slide part as an example,the whole process of simulation of molding and mold opening for mould shaping part of designing is briefly introduced.",
        "keywords": [
            "simulation of mold opening",
            "shaping part",
            "Pro/E",
            "simulation of molding"
        ],
        "authors": [
            {
                "name": "WEI Yan-hong",
                "org": "Mechanical & Electric College,Lanzhou University of Technology,Lanzhou ,China;Mechanical Engineering Department,Lanzhou Petrochemical College of Technology,Lanzhou ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Mechanical & Electric College,Lanzhou University of Technology,Lanzhou ,China"
            }
        ],
        "venue": "Journal of Lanzhou Polytechnic College",
        "year": 2006
    },
    "Y5jC9xJh": {
        "id": "Y5jC9xJh",
        "title": "Design of Control System for JJR-1 Robot",
        "abstract": "For the low precision and instability of JJR-1 robot,a kind of new control system based on AT89S52 processor is introduced.This design simplifies mechanical control system structure use the exclusive control processor LM629N.The experimental applications prove the feasibility of transformation.",
        "keywords": [
            "BIM-418-F",
            "JJR-1 robot",
            "LM629N"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Lanzhou University of Technology,Lanzhou ,China"
            },
            {
                "name": "WANG Hua",
                "org": "Lanzhou University of Technology,Lanzhou ,China"
            }
        ],
        "venue": "New Technology & New Process",
        "year": 2008
    },
    "Z3hPcRKV": {
        "id": "Z3hPcRKV",
        "title": "Swarm Robots Aggregation Formation Control Based on K-means Clustering Algorithm",
        "abstract": "Unknown environment for groups of robots form gathering dynamics formation problem to study,Analysis groups of robots motion control strategy,The K-means clustering algorithm combined with composite body structure formation control strategy,Groups of robots to determine the cluster center;Individual perception of self-produce robot formation according to local vector control activities,Toward the goal,Avoid obstacles;Produce four kinds of behavior control parameters,Determine the size and direction of the robot velocity,Gathered and arranged into a triangle formation round.Simulation results show that the Kmeans clustering algorithm combined with body structure control strategy feasibility and effectiveness.",
        "keywords": [
            "groups of robots",
            "behavior control",
            "K-means clustering algorithm",
            "aggregate formation"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "School of Mechatronic Engineering,Lanzhou University of Technology,Lanzhou ,China"
            },
            {
                "name": "GUO Chun-yang",
                "org": "School of Mechatronic Engineering,Lanzhou University of Technology,Lanzhou ,China"
            },
            {
                "name": "LI Cui-ming",
                "org": "School of Mechatronic Engineering,Lanzhou University of Technology,Lanzhou ,China"
            }
        ],
        "venue": "Modular Machine Tool & Automatic Manufacturing Technique",
        "year": 2012
    },
    "uL0hqi1o": {
        "id": "uL0hqi1o",
        "title": "Dynamic performance analysis of bridge crane with variable external  factors and parameters fixed based on rough set theory",
        "abstract": "Aimed at the effect of external factors such as lifting capacity,dynamic load impact coefficient and mobile crab position on the dynamic performance of crane with fixed structure parameters,the rough set theory was employed to analyze the dynamic performance of the crane.After reduction of attribute,the key factors were extracted from all influencing factors and,meantime,the significances of these key factors were ranked.So that a prediction rule with conformity and completeness was obtained.Compared with other traditional forecasting methods,this method did not need any precondition and could effectively be used to deal with the strong coupling and nonlinear relation between dynamic performances and influencing factors.Its feasibility was verified with its actual application in engineering,providing a new investigation idea and tool for crane dynamic design and performance prediction.",
        "keywords": [
            "rough set theory",
            "dynamic performance",
            "bridge crane",
            "analysis"
        ],
        "authors": [
            {
                "name": "GAO Li-hong",
                "org": "College of Mechano-Electronic Engineering,Lanzhou Univ.of Tech.,Lanzhou ,China"
            },
            {
                "name": "XU Ge-ning",
                "org": "School of Mechanical & Electronical Engineering,Taiyuan University of Science and Technology,Taiyuan ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Mechano-Electronic Engineering,Lanzhou Univ.of Tech.,Lanzhou ,China"
            }
        ],
        "venue": "Journal of Lanzhou University of Technology",
        "year": 2010
    },
    "eRUtIFNj": {
        "id": "eRUtIFNj",
        "title": "Kinematics analysis and simulation of JJR-1 robot based on Matlab",
        "abstract": "Introduces kinematics simulation for JJR-1 robot.Establishing the kinematics model under link-pole coordinate system with the method of Denavit-Hartenberg,and using the Matlab to simulate it.This method provides a basis for research on robot dynamics analysis and control.",
        "keywords": [
            "JJR-1 robot Kinematics Simulation Matlab"
        ],
        "authors": [
            {
                "name": "Yang Ping",
                "org": "Dept.of Mechatronics Engineering,Lanzhou University of Technology,Lanzhou ,CHN"
            },
            {
                "name": "Li Chunling",
                "org": "Dept.of Mechatronics Engineering,Lanzhou University of Technology,Lanzhou ,CHN"
            },
            {
                "name": "Zhang Shuzhen",
                "org": "Dept.of Mechatronics Engineering,Lanzhou University of Technology,Lanzhou ,CHN"
            },
            {
                "name": "Yuan Xiaopeng",
                "org": "Dept.of Mechatronics Engineering,Lanzhou University of Technology,Lanzhou ,CHN"
            }
        ],
        "venue": "Modern Manufacturing Engineering",
        "year": 2006
    },
    "YiqMDLLC": {
        "id": "YiqMDLLC",
        "title": "Research of Collision Detection in Virtual Assembly",
        "abstract": "The interference with detection in the virtual assembly collision as well as removing the interference is mainly is aimed at. According to the assembly, methods are given on how to remove the intervention and given out the detection in collision, the bounding box is built to describe how to create relations between parts and assembly, with which methods are given to describe the function of the object-oriented collision detection algorithm and ways to make out the interference in the amount of final assembly operations. According to the analysis, the proposed method can be better to meet the real-time and mutual requirements in the system, it can also reduce a lot of unnecessary virtual operational links.",
        "keywords": [
            "virtual assembly assembly relations collision detection bounding box"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "School Mechanical and Electrical, Lanzhou University of Technology.Lanzhou ,P.R. China"
            },
            {
                "name": "XIE Hui-qing",
                "org": "School Mechanical and Electrical, Lanzhou University of Technology.Lanzhou ,P.R. China"
            }
        ],
        "venue": "Science Technology and Engineering",
        "year": 2007
    },
    "wePMybOC": {
        "id": "wePMybOC",
        "title": "Research on Military Virtual Driving System",
        "abstract": "Quest3D technology was used in development of virtual driving platform system.The physical simulation of motion body in driving simulation system was realized.Taking DirectX as a port,a military training virtual driving system platform was developed.",
        "keywords": [
            "Physical simulation",
            "Virtual driving",
            "Virtual reality technology"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "College of Mechanical & Electrical Engineering,Lanzhou University of Technology, Lanzhou Gansu ,China"
            },
            {
                "name": "HAN Xiaoming",
                "org": "College of Mechanical & Electrical Engineering,Lanzhou University of Technology, Lanzhou Gansu ,China"
            },
            {
                "name": "LI Leilei",
                "org": "College of Mechanical & Electrical Engineering,Lanzhou University of Technology, Lanzhou Gansu ,China"
            }
        ],
        "venue": "Machine Tool & Hydraulics",
        "year": 2011
    },
    "21QKhNEV": {
        "id": "21QKhNEV",
        "title": "Research about Game Behaviour of Line-following Robot in Artificial Environment",
        "abstract": "In an artificial environment, there are two kinds of line-following robot group, and their benefit is conflicting. Make use of Nash equilibrium and Nash bargaining model, their profit behaviour is research by dissimilar strategy.",
        "keywords": [
            "line-following robot Nash equilibrium Nash bargaining pure strategy"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "College of Mechano-Electronic Engineering, Lanzhou University of Technology, Lanzhou "
            },
            {
                "name": "LIANG Jie",
                "org": "College of Mechano-Electronic Engineering, Lanzhou University of Technology, Lanzhou "
            }
        ],
        "venue": "Science Technology and Engineering",
        "year": 2006
    },
    "GBxZkcAo": {
        "id": "GBxZkcAo",
        "title": "Design of in-pipe clearing ash robot system",
        "abstract": "Based on In-pipe clearing ash robot in exhaust gas pipeline of metal smeltery object,the scheme of in-pipe clearing ash robot with track to clean out ash in pipe is put forward.Configuration and driver of the robot is explained.Kinematics characteristic and several especial locations for operating arm are analyzed,as well as dead point of the mechanism and means how to keep away from it is given.",
        "keywords": [
            "Robot",
            "Tracked",
            "In-pipe clearing ash",
            "Kinematics characteristic"
        ],
        "authors": [
            {
                "name": "ZHANG Shu-zhen",
                "org": "College of Mechano-Electronic Engineering,Lanzhou Univ.of Tech.,Lanzhou ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Mechano-Electronic Engineering,Lanzhou Univ.of Tech.,Lanzhou ,China"
            },
            {
                "name": "YUAN Xiao-peng",
                "org": "College of Mechano-Electronic Engineering,Lanzhou Univ.of Tech.,Lanzhou ,China"
            }
        ],
        "venue": "Machinery Design & Manufacture",
        "year": 2006
    },
    "fqb1EKTf": {
        "id": "fqb1EKTf",
        "title": "Research on Racing-Robot Systems for Competition",
        "abstract": "The racing-robot systems was researched and designed based on the theory of modern control,modern design methods and sensor engineering.The control principle and the realization method of racing-robot were expounded.Two-circuit H bridge type circuit was used to construct the drive of the direct current electromotor.S7136 infrared chipset was used as the sensor of the road's situation.The experimental result shows that the system has better ability of detection and recognition,quick responding velocity,good stability,strong anti-disturbance.",
        "keywords": [
            "Signal transmission",
            "H8/3048 MCU",
            "Sensor",
            "Detection"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Lanzhou University of Technology,Lanzhou Gansu ,China"
            },
            {
                "name": "LI Yao",
                "org": "Lanzhou University of Technology,Lanzhou Gansu ,China"
            },
            {
                "name": "SHI Xiaoxing",
                "org": "Lanzhou University of Technology,Lanzhou Gansu ,China"
            },
            {
                "name": "ZHANG Li",
                "org": "Lanzhou University of Technology,Lanzhou Gansu ,China"
            },
            {
                "name": "LI Cuiming",
                "org": "Lanzhou University of Technology,Lanzhou Gansu ,China"
            }
        ],
        "venue": "Machine Tool & Hydraulics",
        "year": 2010
    },
    "1WGSB57G": {
        "id": "1WGSB57G",
        "title": "Wireless Control Based on JJR-1 Educational Robot",
        "abstract": "A method based on JJR-1 educational robot as control object,is provided using the wireless receive and send digital transmit MODEM PTR2030 to achieve wireless data communication between PC and singlechip which is controlling D.C.lorque motor in each joint.",
        "keywords": [
            "JJR-1 educational robot wireless communication PTR2030"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "College of Mechano-Electronic Engineering,Lanzhou University of Technology,Lanzhou ,P.R.China"
            },
            {
                "name": "LIANG Jie",
                "org": "College of Mechano-Electronic Engineering,Lanzhou University of Technology,Lanzhou ,P.R.China"
            }
        ],
        "venue": "Science Technology and Engineering",
        "year": 2007
    },
    "ZkE87EUd": {
        "id": "ZkE87EUd",
        "title": "Design of kinematic system for new high-speed heavy-duty stacking robot",
        "abstract": "For high-speed and heavy duty stacking condition on high-volume production line of aluminum ingot stacking,a new stacking robot composed of hybrid serial-parallel mechanism with five-degree of freedom was researched and designed.The structural module of robot body took kinematic system scheme with closed-loop kinematic chain composed of parallel and serial mechanisms.By means of parameterizational modelling for the system,analyzing theoretically the kinematic characteristics,simulating the system motion with virtual experiment,and analyzing the motion with finite element method,movement system of the robot was made be able to meet the requirement of degree of freedom,working space and complexity of stacking track.The capacity of the robot was substantially increased,being able to meet the requirement of high-speed and heavy-duty stacking of aluminum ingots.",
        "keywords": [
            "parallel mechanism",
            "high-speed",
            "stacking robot",
            "heavy duty"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "College of Mechano-Electronic Engineering,Lanzhou Univ.of Tech.,Lanzhou ,China"
            },
            {
                "name": "YIN Yan-jun",
                "org": "College of Mechano-Electronic Engineering,Lanzhou Univ.of Tech.,Lanzhou ,China"
            },
            {
                "name": "ZHANG Li",
                "org": "College of Mechano-Electronic Engineering,Lanzhou Univ.of Tech.,Lanzhou ,China"
            },
            {
                "name": "LI Cui-ming",
                "org": "College of Mechano-Electronic Engineering,Lanzhou Univ.of Tech.,Lanzhou ,China"
            }
        ],
        "venue": "Journal of Lanzhou University of Technology",
        "year": 2010
    },
    "Tu5edIRU": {
        "id": "Tu5edIRU",
        "title": "Rough set based dynamic performance analysis of gantry crane",
        "abstract": "for the impact on the dynamic performance imposed by structural parameters such as the bridge weight,trolley frame weight,the corresponding stiffness coefficients of gantry crane,the paper analyzes the dynamic performance of the crane using rough set theory,through the reduction of attributes,extracts key factors from many factors,and ranks the importance of each factor,obtaining a consistent and comprehensive forecasting rules.Compared with traditional methods,the method requires no assumptions,and can effectively handle the close coupling and non-linear relationship between dynamic performance and influence factors.The paper verifies the feasibility through the practical application,providing new research ideas and means for the dynamic design and forecasting implementation of the crane.",
        "keywords": [
            "attribute reduction",
            "rough set theory",
            "dynamic performance",
            "gantry crane",
            "analysis"
        ],
        "authors": [
            {
                "name": "Gao Lihong",
                "org": ""
            },
            {
                "name": "Xu Gening",
                "org": ""
            },
            {
                "name": "Yang Ping",
                "org": ""
            }
        ],
        "venue": "Hoisting and Conveying Machinery",
        "year": 2011
    },
    "ffKhVmMQ": {
        "id": "ffKhVmMQ",
        "title": "Operational principle and dynamic analysis of a new-type water-jet propeller",
        "abstract": "Aimed at the problem of high dissipation of energy,high cost and complicated recovery and restoration with the traditional and water-jet propellers,a highly-efficiency water-jet propeller working with planetary gear train was put forward.It would be suitable for high-speed,small-scale underwater vehicles and robots that work in the shallow water and certain small surface ships as well.Working process of this water-jet propeller was introduced.The operational principle of the planetary gear propulsion was explained by means of homogeneous transformation of coordinate,systems and its kinematic analysis was conducted,so that the displacement,speed and acceleration of the propulsion end were determined.The dynamic analysis was carried out by using the modules of dynamic mechanism analysis and simulation in the software Pro/E.The correctness of kinematics analysis of the planetary gear propulsion and the validity of operational principle of the water-jet propeller were verified.",
        "keywords": [
            "water-jet propeller",
            "principle analysis",
            "dynamic simulation",
            "kinematic analysis"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "College of Mechano-Electronical Engineering,Lanzhou Univ.of Tech.,Lanzhou ,China"
            },
            {
                "name": "ZHANG Cui-ying",
                "org": "College of Mechano-Electronical Engineering,Lanzhou Univ.of Tech.,Lanzhou ,China"
            },
            {
                "name": "ZHANG Shu-zhen",
                "org": "College of Mechano-Electronical Engineering,Lanzhou Univ.of Tech.,Lanzhou ,China"
            }
        ],
        "venue": "Journal of Lanzhou University of Technology",
        "year": 2009
    },
    "mcDfSNFc": {
        "id": "mcDfSNFc",
        "title": "Kinematics analysis and simulation for operating arm of in-pipe clearing ash robot based on analytic method",
        "abstract": "Regarding in-pipe clearing ash robot in exhaust gas pipeline of metal smeltery as the research object, operating arm framework sketch of the robot is set up. Utilizing the analytic method the arm displacement, speed and acceleration are analyzed and solved. Computing program is designed in Matlab. Simulation model of the robot mechanical system is set up in Simulink and the robot dynamic simulation is carried on. The correctness of kinematic analysis was verified.",
        "keywords": [
            "Analytic method",
            "In-pipe clearing ash robot",
            "Operating arm",
            "Simulation"
        ],
        "authors": [
            {
                "name": "Shuzhen Zhang",
                "org": "Lanzhou University of Technology(Lanzhou University of Technology),Lanzhou,China"
            },
            {
                "name": "Ping Yang",
                "org": "Lanzhou University of Technology(Lanzhou University of Technology),Lanzhou,China"
            },
            {
                "name": "XingWu Dang",
                "org": "Lanzhou University of Technology(Lanzhou University of Technology),Lanzhou,China"
            }
        ],
        "venue": "Nongye Jixie Xuebao/Transactions of the Chinese Society of Agricultural Machinery",
        "year": 2006
    },
    "DdiJOVRc": {
        "id": "DdiJOVRc",
        "title": "Effects of Controls of Invasive Spartina alterniflora on Soil Organic Carbon and Nutrient Contents in the Min River Estuary",
        "abstract": "Control and management of invasive Spartina plants is a great challenge to human society,and the effects of different controlling methods of invasive S.alterniflora on soil organic carbon(SOC) and nutrient contents had been paid attentions.After mowing S.alterniflora and waterlogging treatment,no other plants were cultured for three years,the SOC contents in the depth of 40 cm significantly lower than that in the S.alterniflora marsh;mowing S.alterniflora and then transforming to Boleophthalmus pectinirostris farm,the SOC contents in the depth of 40 cm dropped a little compared with the S.alterniflora marsh,however,the difference was not significant;the soil TN and TP contents were also statistically indistinguishable,but the soil organic nitrogen content increased significantly;mowing S.alterniflora and doing 45 days of waterlogging treatment,whether growing Cyperus malaccensis or not at eight months,there was no significant difference in the SOC contents in the depth of 40 cm compared with the S.alterniflora marsh.",
        "keywords": [
            "soil organic carbon",
            "Spartina alterniflora",
            "mowing+farming Boleophthalmus pectinirostris",
            "mowing+waterlogging+planting Cyperus malaccensis",
            "Min river estuary"
        ],
        "authors": [
            {
                "name": "TONG Chuan",
                "org": "Research Centre of Wetlands in Sub-tropical Regions,Key Laboratory of Humid Sub-tropical Eco-geographical Process of Ministry of Education,Fujian Normal University,Fuzhou "
            },
            {
                "name": "LI Xu-wei",
                "org": "Research Centre of Wetlands in Sub-tropical Regions,Key Laboratory of Humid Sub-tropical Eco-geographical Process of Ministry of Education,Fujian Normal University,Fuzhou "
            },
            {
                "name": "YONG Shi-quan",
                "org": "Research Centre of Wetlands in Sub-tropical Regions,Key Laboratory of Humid Sub-tropical Eco-geographical Process of Ministry of Education,Fujian Normal University,Fuzhou "
            },
            {
                "name": "YANG Ping",
                "org": "Research Centre of Wetlands in Sub-tropical Regions,Key Laboratory of Humid Sub-tropical Eco-geographical Process of Ministry of Education,Fujian Normal University,Fuzhou "
            },
            {
                "name": "HUANG Jia-fang",
                "org": "Research Centre of Wetlands in Sub-tropical Regions,Key Laboratory of Humid Sub-tropical Eco-geographical Process of Ministry of Education,Fujian Normal University,Fuzhou "
            }
        ],
        "venue": "Journal of Soil and Water Conservation",
        "year": 2012
    },
    "EqHYczmD": {
        "id": "EqHYczmD",
        "title": "Greenhouse gas flux from forests and wetlands:a review of the effects of disturbance",
        "abstract": "Forest and wetland ecosystems are significant carbon and nitrogen sinks at the global scale,and play an important role sequestering greenhouse gases and regulating climate.The three greenhouse gases fluxes from forest and wetland ecosystems are influenced by many factors,including disturbance.Here,we review the effects of disturbance on greenhouse gases fluxes from forest and wetlands.We separate the effects due to disturbance into two types: disturbance brought about by human activity and through natural means.The former includes forest-harvesting,fertilization,reclamation and tillage,and the latter includes fire,typhoon and hurricane.We discuss the impacts of these different disturbances on the fluxes of CO2,CH4 and N2O from both forest and wetland ecosystems.In many cases the conclusions from the literature were not consistent.Harvesting increased forest soil respiration in most studies;however,there was also one report showing that soil respiration dropped markedly because of a reduction in carbon input after forest removal.The response of three greenhouse gases to harvesting was also not consistent.Reclamation,a major disturbance in wetlands,tended to produce large impacts on the carbon and nitrogen dynamics.Some studies demonstrated an increased CO2 emission when marshlands were transformed to farmland,whereas another reports concluded that marsh reclamation caused the drop in CO2 emission.CH4 flux often decreased,and N2O flux generally increased when the marshes were reclaimed.The effects of fertilizer nitrogen input on greenhouse gases production and emission from marshes soil were complex with differences induced by different nitrogen fertilizers(NH4NO3,(NH4)2SO4,KNO3 and urea).The intensity of fire appeared to have an important influence on CH4 flux;a low-intensity fire increases CH4 flux,whereas a high-intensity fire will decrease CH4 flux.The CO2 flux-responses were also complex;some studies showed that fire inhibited CO2 flux,but others showed promotion effects.Tropical storms(typhoons and hurricanes) are a common disturbance feature in tropical and subtropical coastal forest and wetland ecosystems.CO2 emission generally dropped after the storm and N2O flux often increased. We concluded our review with an analysis of trends in current research,and pointed out some urgent and key directions in future.A major suggestion was that it is becoming increasingly necessary to understand the mechanism through which the different types of disturbance influence greenhouse gases fluxes from forest and wetland ecosystems,and in particular to assess the effects at different spatial and temporal scales.",
        "keywords": [
            "methane",
            "natural disturbance",
            "wetland",
            "nitrous oxide",
            "forest",
            "human disturbance",
            "carbon dioxide"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": " Key Laboratory of Humid Sub-tropical Eco-geographical Process of Ministry of Education,Research Centre of Wetlands in Subtropical Region,School of Geographical Sciences,Fujian Normal University,Fuzhou ,China"
            },
            {
                "name": "TONG Chuan",
                "org": " Key Laboratory of Humid Sub-tropical Eco-geographical Process of Ministry of Education,Research Centre of Wetlands in Subtropical Region,School of Geographical Sciences,Fujian Normal University,Fuzhou ,China"
            }
        ],
        "venue": "Acta Ecologica Sinica",
        "year": 2012
    },
    "lm832LZT": {
        "id": "lm832LZT",
        "title": "Greenhouse gases fluxes at water-air interface of aquaculture ponds and influencing factors in the Min River estuary",
        "abstract": "Variations of CO2, CH4 and N2O fluxes at water-air interface in the daytime were determined using a floating chamber- gas chromatography method in a mixed culture pond of fish and shrimp from September 2011 to January 2012 in the Shanyutan Wetland of the Min River estuary, southeast China. Meanwhile, the meteorological indicators in ground surface and the physical, chemical and biological indicators of surface water were also measured. The fluxes of CO2, CH4 and N2O at the water-air interface showed an obvious temporal variations during observation. CO2, CH4 and N2O fluxes ranged from -22.15 to 74.79 mg \u00b7 m-2 \u00b7 h-1, 0.08 to 6.62 mg \u00b7 m-2 \u00b7 h-1 and -9.82 to 47.16 \u03bcg \u00b7 m-2 \u00b7 h-1, respectively, with the average values of 21.04, 3.15 and 16.58 \u03bcg \u00b7 m-2 \u00b7 h-1, respectively. The mixed culture pond of fish and shrimp functioned as a source of CO2, CH4 and N2O. The greenhouse gases fluxes at water-air interface were influenced by many factors, including human activities (water quality management and bait launch), growth of fish and shrimp, meteorological factors, and physical and chemical properties of water.",
        "keywords": [
            "Aquaculture ponds",
            "Carbon dioxide",
            "Flux",
            "Methane",
            "Min River estuary",
            "Nitrous oxide",
            "Water-air interface"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "Fujian Normal University(Fujian Normal University ^),Fuzhou,China"
            },
            {
                "name": "Chuan Tong",
                "org": "Fujian Normal University(Fujian Normal University ^),Fuzhou,China"
            },
            {
                "name": "QingHua He",
                "org": "Fujian Normal University(Fujian Normal University ^),Fuzhou,China"
            },
            {
                "name": "JiaFang Huang",
                "org": "Fujian Normal University(Fujian Normal University ^),Fuzhou,China"
            }
        ],
        "venue": "Huanjing Kexue Xuebao/Acta Scientiae Circumstantiae",
        "year": 2013
    },
    "eQARHGM9": {
        "id": "eQARHGM9",
        "title": "Effects of LUCC on Carbon Stocks and Emission in Wetland",
        "abstract": "Wetland ecosystem is an important carbon pool on the earth.The changes of carbon stocks and emission play an important role in carbon cycle and global climate change.The change of wetland carbon stocks is influenced by many factors,and land use/cover change(LUCC) is one of the major factors.The studies suggest that LUCC has affected the carbon stocks and emission by changing vegetation cover,soil moisture,redox potentials and microbial activity.A large quantity of carbon was released after cultivation of wetland,and the functions of carbon sink and carbon source were changed.",
        "keywords": [
            "CH4",
            "Wetland",
            "CO2",
            "LUCC",
            "Carbon stock"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Key Laboratory of Humid Sub-tropical Eco-geographical Process of the Ministry of Education,Research Centre of Wetlands in Subtropical Region,School of Geographical Sciences,Fujian Normal Universities,Fuzhou "
            },
            {
                "name": "TONG Chuan",
                "org": "Key Laboratory of Humid Sub-tropical Eco-geographical Process of the Ministry of Education,Research Centre of Wetlands in Subtropical Region,School of Geographical Sciences,Fujian Normal Universities,Fuzhou "
            }
        ],
        "venue": "Wetland Science & Management",
        "year": 2011
    },
    "UbilX014": {
        "id": "UbilX014",
        "title": "Diurnal variations of greenhouse gas fluxes at the water-air interface of aquaculture ponds in the Min River estuary",
        "abstract": "Wetland reclamation and aquaculture is one of the main disturbance types in coastal wetlands. Diurnal variations of CO2, CH4 and N2O fluxes at the water-air interface were determined using a floating chambers + gas chromatography method in a shrimp pond, and a mixed culture pond of fish and shrimp in October in the Shanyutan Wetland of the Min River estuary, southeast China. Meanwhile, the meteorological indicators in ground surface and physical, chemical and biological indicators of surface water were also measured. CO2, CH4 and N2O fluxes at the water-air interface all demonstrated distinct diurnal variations. Both shrimp pond and mixed culture pond of fish and shrimp functioned as a sink of CO2 [the diurnal averaged CO2 fluxes were -48.79 and -105.25 mg x (m2 x h)(-1), respectively], and a source of CH4 [the diurnal averaged CH4 fluxes were 1.00 and 5.74 mg x (m2 x h)(-1), respectively]; the diurnal averaged CO2 and CH4 fluxes at the water-air interface of the mixed culture of fish and shrimp pond were higher than that of the shrimp pond. Greenhouse gas fluxes at the water-air interface from the aquaculture ponds were influenced by many factors. Multiple stepwise regression analysis showed that the concentration of Chlorophyll was the major factor affecting the CO2 fluxes, and the concentrations of SO4(2-) and PO4(3-) were the major factors affecting the CH4 fluxes at the water-air interface of the shrimp pond; whereas water temperature and Chlorophyll were the major factors affecting the CO2 fluxes, and dissolved oxygen, PO4(3-) and pH were the major factors affecting the CH4 fluxes at the water-air interface of the mixed culture pond of fish and shrimp.",
        "keywords": [
            "Aquaculture ponds",
            "CH4",
            "CO2",
            "Diurnal variations",
            "Min River estuary",
            "N2O",
            "Water-air interface"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "Fujian Normal University(Fujian Normal University ^),Fuzhou,China"
            },
            {
                "name": "Chuan Tong",
                "org": "Fujian Normal University(Fujian Normal University ^),Fuzhou,China"
            },
            {
                "name": "Qing-Hua He",
                "org": "Fujian Normal University(Fujian Normal University ^),Fuzhou,China"
            },
            {
                "name": "Jia-Fang Huang",
                "org": "Fujian Normal University(Fujian Normal University ^),Fuzhou,China"
            }
        ],
        "venue": "Huan jing ke xue= Huanjing kexue / [bian ji, Zhongguo ke xue yuan huan jing ke xue wei yuan hui \"Huan jing ke xue\" bian ji wei yuan hui.]",
        "year": 2012
    },
    "Kr7ucrPE": {
        "id": "Kr7ucrPE",
        "title": "[Porewater Dissolved Methane in Cyperus malaccensis Marshes Along Salinity Gradient in the Minjiang River Estuary].",
        "abstract": "Physicochemical properties of soil and dissolved methane concentrations of porewater in the sediments of the Cyperus malaccensis marshes along a salinity gradient in the Minjiang River estuary were evaluated, and the spatial-temporal characteristics and main impact factors were discussed. The average concentrations of dissolved methane in porewater were 331.18, 299.94 and 638.58 \u03bcmol x L(-1), respectively in the Shanyutan, Bianfuzhou and Xiayangzhou wetlands in summer. In the winter, they were 9.04, 266.67 and 322.68 \u03bcmol x L(-1), respectively. The dissolved methane concentration in porewater was higher in summer than those in winter (P < 0.05). Overall, the concentrations of dissolved methane in porewatdr showed an increasing trend from brackish to freshwater marshes. Multivariate statistics analysis showed that the concentrations of dissolved methane in porewater was positively correlated with soils temperature and DOC (P < 0.05), but negatively correlated with soils pH, salinity, and the concentrations of porewater SO4(2-) and Cl-. Spatial-temporal distribution of porewater dissolved methane in estuarine marshes represents a final result of multiple factors, including soil physicochemical properties and hydrodynamic condition.",
        "keywords": "",
        "authors": [
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Zi-chuan Zhang",
                "org": ""
            },
            {
                "name": "Wei-ning Du",
                "org": ""
            },
            {
                "name": "Jia-fang Huang",
                "org": ""
            },
            {
                "name": "Chuan Tong",
                "org": ""
            }
        ],
        "venue": "Huan jing ke xue= Huanjing kexue",
        "year": 2015
    },
    "tdkoQ454": {
        "id": "tdkoQ454",
        "title": "Effect of drainage on CO 2 , CH 4 , and N 2 O fluxes from aquaculture ponds during winter in a subtropical estuary of China.",
        "abstract": "Aquaculture ponds are dominant features of the landscape in the coastal zone of China. Generally, aquaculture ponds are drained during the non-culture period in winter. However, the effects of such drainage on the production and flux of greenhouse gases (GHGs) from aquaculture ponds are largely unknown. In the present study, field-based research was performed to compare the GHG fluxes between one drained pond (DP, with a water depth of 0.05m) and one undrained pond (UDP, with a water depth of 1.16m) during one winter in the Min River estuary of southeast China. Over the entire study period, the mean CO flux in the DP was (0.75\u00b10.12) mmol/(m\u00b7hr), which was significantly higher than that in the UDP of (-0.49\u00b10.09) mmol/(m\u00b7hr) (p<0.01). This indicates that drainage drastically transforms aquaculture ponds from a net sink to a net source of CO in winter. Mean CH and NO emissions were significantly higher in the DP compared to those in the UDP (CH=(0.66\u00b10.31) vs. (0.07\u00b10.06) mmol/(m\u00b7hr) and NO=(19.54\u00b12.08) vs. (0.01\u00b10.04) \u00b5mol/(m\u00b7hr)) (p<0.01), suggesting that drainage would also significantly enhance CH and NO emissions. Changes in environmental variables (including sediment temperature, pH, salinity, redox status, and water depth) contributed significantly to the enhanced GHG emissions following pond drainage. Furthermore, analysis of the sustained-flux global warming and cooling potentials indicated that the combined global warming potentials of the GHG fluxes were significantly higher in the DP than in the UDP (p<0.01), with values of 739.18 and 26.46mgCO-eq/(m\u00b7hr), respectively. Our findings suggested that drainage of aquaculture ponds can increase the emissions of potent GHGs from the coastal zone of China to the atmosphere during winter, further aggravating the problem of global warming.",
        "keywords": [
            "Aquaculture pond",
            "Drainage management",
            "Global warming",
            "Greenhouse gas flux",
            "Min River estuary"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "School of Geographical Sciences, Fujian Normal University, Fuzhou 350007, China; Key Laboratory of Humid Sub-tropical Eco-geographical Process of Ministry of Education of China, Fujian Normal University, Fuzhou 350007, China. Electronic address: yangping528@sina.cn."
            },
            {
                "name": "Derrick Y F Lai",
                "org": "Department of Geography and Resource Management, and Centre for Environmental Policy and Resource Management, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China."
            },
            {
                "name": "Jia F Huang",
                "org": "School of Geographical Sciences, Fujian Normal University, Fuzhou 350007, China; Key Laboratory of Humid Sub-tropical Eco-geographical Process of Ministry of Education of China, Fujian Normal University, Fuzhou 350007, China."
            },
            {
                "name": "Chuan Tong",
                "org": "School of Geographical Sciences, Fujian Normal University, Fuzhou 350007, China; Key Laboratory of Humid Sub-tropical Eco-geographical Process of Ministry of Education of China, Fujian Normal University, Fuzhou 350007, China. Electronic address: tongch@fjnu.edu.cn."
            }
        ],
        "venue": "Journal of environmental sciences (China)",
        "year": 2018
    },
    "gWi43u0u": {
        "id": "gWi43u0u",
        "title": "Palynological record of Holocene vegetation and climate changes in a high-resolution peat profile from the Xinjiang Altai Mountains, northwestern China",
        "abstract": "Abstract   A high-resolution pollen record in a peat sequence from the Altai Mountains of Xinjiang, China, allows reconstruction of the regional vegetation and climate changes that occurred during the Holocene. Pollen distributions from the sequence indicate that the vegetation community in the Altai Mountains region transitioned through five general phases: forest and desert steppe, wet steppe, desert steppe, steppe, and finally forest and desert steppe. These vegetative phases imply that the regional climate changed from a cold and dry early Holocene to a warmer and wetter early-mid Holocene and then to a cold and rather dry mid-Holocene that was followed by a cool and wet late Holocene and finally by warm and dry conditions for the last millennium. These regional changes in climate are roughly consistent with local changes previously reconstructed from organic geochemical paleoclimate proxies in the same peat sequence by Zhang et\u00a0al. (2016), but with some minor but important differences that reflect local factors.  Regional comparisons reveal that the Holocene climate changes in the Altai Mountains are generally consistent with those of most arid central Asian regions that are influenced mainly by westerlies. However, they are out-of-phase with the climate histories of regions controlled by the Asian monsoons, indicating that the Asian monsoons did not extend to the high-altitude mountain regions of arid central Asia during the Holocene. We postulate that the regional Holocene moisture variations have been mainly modulated by NAO variations that affected transport of water vapor from the North Atlantic Ocean by the westerlies. Moreover, local factors that include topography of the mountains and glacial meltwater events in the high-altitude regions also contributed to the climate changes in the Altai Mountains. In addition, air temperatures related to summer insolation of the Northern Hemisphere might have played an important role in modulating moisture in the region, but only after the local montane ice-sheets had disappeared by the mid-Holocene.",
        "keywords": "",
        "authors": [
            {
                "name": "Yan Zhang",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": "Key Laboratory of Humid Subtropical Eco-Geographical Process, Ministry of Education, Institute of Geographical Sciences, Fujian Normal University, Fuzhou, 350007, China"
            },
            {
                "name": "Chuan Tong",
                "org": "Key Laboratory of Humid Subtropical Eco-Geographical Process, Ministry of Education, Institute of Geographical Sciences, Fujian Normal University, Fuzhou, 350007, China"
            },
            {
                "name": "Xingtu Liu",
                "org": "Key Laboratory of Wetland Ecology and Environment, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Changchun, 130102, China"
            },
            {
                "name": "Zhenqing Zhang",
                "org": ""
            },
            {
                "name": "Guoping Wang",
                "org": "Key Laboratory of Wetland Ecology and Environment, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Changchun, 130102, China"
            }
        ],
        "venue": "Quaternary Science Reviews",
        "year": 2018
    },
    "kz2wGjO6": {
        "id": "kz2wGjO6",
        "title": "Carbon dioxide dynamics from sediment, sediment-water interface and overlying water in the aquaculture shrimp ponds in subtropical estuaries, southeast China.",
        "abstract": "Aquaculture ponds can emit a large amount carbon dioxide (CO), with the consequence of exacerbating global climate change. Many studies about CO dynamics across the water-air interface, but CO in sediment and overlying water received relative less attention. In this study, CO concentration in sediment porewater, the diffusive CO fluxes across the sediment-water interface (SWI), and the CO production rates in the overlying water (CO) were determined in the shrimp ponds in the Min River Estuary (MRE) and Jiulong River Estuary (JRE), southeast China, to analyze the dynamics of CO among different growth stages of shrimps. Our results showed large variations in porewater CO concentrations, CO diffusive fluxes and CO rates among different growth stages, with markedly larger values in the middle stage of shrimp growth. The temporal variation of CO in both estuarine ponds followed closely the seasonal change of temperature. The internal CO production (CO) in these ponds was dominated by sediments. A significantly larger mean porewater CO concentrations, diffusive fluxes and production rate were observed in the MRE ponds than those in the JRE ponds, which could be attributed to the lower water salinity and a larger source of carbon substrates in the former estuary. Considering a total surface area of 6.63\u202f\u00d7\u202f10\u202fkm across the mariculture ponds in subtropical estuaries, it is estimated conservatively that approximately 100 Gigagram (Gg) of dissolved organic carbon and 190\u202fGg of dissolved inorganic carbon were transported annually from the mariculture ponds into China's coastal areas. Because of the substantial supply of dissolved carbon, the adjacent coastal waters receiving effluent discharge from the mariculture ponds could become \"hotspots\" of CO emissions. Our results highlight the role of aquaculture pond as a major CO source in China's coastal areas, and effective actions are needed to alleviate the greenhouse gas (GHG) emissions from these ponds.",
        "keywords": [
            "Carbon dioxide",
            "Mariculture ponds",
            "Production rates",
            "Sediment-water interface",
            "Subtropical estuary"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "Key Laboratory of Humid Subtropical Eco-geographical Process of Ministry of Education, Fujian Normal University, Fuzhou, 350007, PR China; School of Geographical Sciences, Fujian Normal University, Fuzhou, 350007, PR China; Research Centre of Wetlands in Subtropical Region, Fujian Normal University, Fuzhou, 350007, PR China. Electronic address: yangping528@sina.cn."
            },
            {
                "name": "DerrickY F Lai",
                "org": "Department of Geography and Resource Management, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China."
            },
            {
                "name": "Hong Yang",
                "org": "Collaborative Innovation Center of Atmospheric Environment and Equipment Technology\uff0c Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, School of Environmental Science and Engineering, Nanjing University of Information Science & Technology, 219 Ningliu Road, Nanjing, 210044, PR China; College of Environmental Science and Engineering, Fujian Normal University, Fuzhou, 350007, PR China; Department of Geography and Environmental Science, University of Reading, Whiteknights, Reading, RG6 6AB, UK."
            },
            {
                "name": "Chuan Tong",
                "org": "Key Laboratory of Humid Subtropical Eco-geographical Process of Ministry of Education, Fujian Normal University, Fuzhou, 350007, PR China; School of Geographical Sciences, Fujian Normal University, Fuzhou, 350007, PR China; Research Centre of Wetlands in Subtropical Region, Fujian Normal University, Fuzhou, 350007, PR China. Electronic address: tongch@fjnu.edu.cn."
            }
        ],
        "venue": "Journal of environmental management",
        "year": 2019
    },
    "OkoCUHVB": {
        "id": "OkoCUHVB",
        "title": "[Nutrient Distribution of Overlying Water in Tidal Marshes in Five Estuaries and Bays of the Fuzhou Region in Autumn].",
        "abstract": "Overlying water from the tidal marshes in five estuaries and bays, namely, Xinghua Bay (Fuzhou Part), Fuqing Bay, Luoyuan Bay, Minjiang River Estuary, and Aojiang River Estuary of the Fuzhou region were collected in autumn of 2015, and the nitrogen and phosphorus nutrient concentration and other physical and chemical indicators of the overlying water were measured to discuss the reasons for the differences in the nutrient concentration of the overlying water in tidal marsh wetlands in different bays and estuaries. There were significant differences in the nitrogen and phosphorus nutrient concentrations of the overlying waters of the tidal marshes in the different bays and estuaries (<0.05). The concentrations of nitrogen and phosphorus in Fuqing Bay were relatively high, while Xinghua Bay had the lowest nitrogen nutrient concentration and Aojiang River Estuary had the lowest phosphorus nutrient concentration. The nutrient concentration of the overlying water in Fuqing Bay is mainly affected by regional aquaculture, land-source pollution, and topography, while that in Xinghua Bay is mainly affected by tides. The vegetation type had an effect on the nutrient concentration of the overlying water in the wetlands. The concentration of nitrogenous nutrients in the overlying water of the marsh wetland in the  community was relatively high, while the nitrogen and phosphorus nutrient concentrations in the overlying water of the  community wetland was relatively low; the concentrations of nutrients in the overlying water of different plant communities in the same bay or estuary marsh wetland were different, and the relationships were complex. Tides, surface runoff, plant communities, topography, and human activities all had an important impact on the nutrient concentrations in the overlying waters of the bay and estuary wetlands.",
        "keywords": [
            "Fuzhou",
            "estuary/bay",
            "nutrient",
            "overlying water",
            "plant community",
            "wetlands"
        ],
        "authors": [
            {
                "name": "Lu-Lu He",
                "org": "School of Geographical Sciences, Fujian Normal University, Fuzhou 350007, China."
            },
            {
                "name": "Ping Yang",
                "org": "School of Geographical Sciences, Fujian Normal University, Fuzhou 350007, China."
            },
            {
                "name": "Li-Shan Tan",
                "org": "School of Geographical Sciences, Fujian Normal University, Fuzhou 350007, China."
            },
            {
                "name": "Chuan Tong",
                "org": "Research Centre of Wetlands in Subtropical Region, Fujian Normal University, Fuzhou 350007, China."
            },
            {
                "name": "Jia-Fang Huang",
                "org": "Research Centre of Wetlands in Subtropical Region, Fujian Normal University, Fuzhou 350007, China."
            }
        ],
        "venue": "Huan jing ke xue= Huanjing kexue",
        "year": 2019
    },
    "ga3V0wRv": {
        "id": "ga3V0wRv",
        "title": "[Diffusive CO 2 Flux Across the Water-air Interface of Reclaimed Shrimp Ponds in the Minjiang River Estuary Based on the TBL Model].",
        "abstract": "Freshwater aquatic ecosystems are important sources of greenhouse gases, such as CO. However, few studies have presented data on the greenhouse gas flux from coastal aquaculture ponds. Diffusion models are important tools for estimating the CO exchange flux across the water-air interface of aquatic ecosystems. Several different parameterized means were selected to estimate the CO gas exchange rate () and CO diffusive flux across the water-air interface of shrimp ponds in the Minjiang River Estuary. The results indicated that:\u2460 the CO gas exchange rate and diffusive flux over the culture period all presented significant temporal variation. This variation showed a dynamic trend:October > September > November > July > August and November > July > August > September > October. \u2461 Wind speed, , CO concentration, pH, DOC concentration, and Chl-a concentration were important factors affecting the temporal variation of CO diffusive flux. \u2462 There were differences in the estimated value of CO diffusive flux across the water-air interface of the culture ponds in the Minjiang River Estuary among different parameterized approaches (<0.01). This indicates that the model method has some uncertainties in estimating the CO diffusive flux in culture ponds. Our results suggest that the models RC01 and CW03 are more suitable methods for estimating the CO diffusive flux at the water-air interface of estuarine reclaimed aquaculture ponds in the Minjiang River Estuary, after comprehensive analysis of the water environment and the different estimation results.",
        "keywords": [
            "Minjiang River Estuary",
            "carbon dioxide",
            "diffusive flux",
            "gas exchange rate",
            "model",
            "shrimp pond"
        ],
        "authors": [
            {
                "name": "Yi-Fei Zhang",
                "org": "School of Geographical Sciences, Fujian Normal University, Fuzhou 350007, China."
            },
            {
                "name": "Ping Yang",
                "org": "Key Laboratory of Humid Sub-tropical Eco-geographical Process of Ministry of Education, Fuzhou 350007, China."
            },
            {
                "name": "Guang-Hui Zhao",
                "org": "School of Geographical Sciences, Fujian Normal University, Fuzhou 350007, China."
            },
            {
                "name": "Ling Li",
                "org": "School of Geographical Sciences, Fujian Normal University, Fuzhou 350007, China."
            },
            {
                "name": "Li-Shan Tan",
                "org": "School of Geographical Sciences, Fujian Normal University, Fuzhou 350007, China."
            },
            {
                "name": "Chuan Tong",
                "org": "Key Laboratory of Humid Sub-tropical Eco-geographical Process of Ministry of Education, Fuzhou 350007, China."
            }
        ],
        "venue": "Huan jing ke xue= Huanjing kexue",
        "year": 2019
    },
    "iqQWLUjp": {
        "id": "iqQWLUjp",
        "title": "Fluxes of carbon dioxide and methane across the water-atmosphere interface of aquaculture shrimp ponds in two subtropical estuaries: The effect of temperature, substrate, salinity and nitrate.",
        "abstract": "While aquaculture pond is a dominant land use/cover type and a distinct aquatic ecosystem in the coastal zones of China and southeast Asia, their contributions to the fluxes of greenhouse gases (GHGs) have only been poorly quantified. Fluxes of CO and CH in the shrimp ponds with different salinities were simultaneously measured in situ using the floating chamber technique in two different subtropical estuaries, namely, the Min River Estuary (MRE) and Jiulong River Estuary (JRE). The average CO and CH fluxes in the shrimp ponds over the observation periods varied from -2.09 to 3.37mmol CO mh and from 0.28 to 16.28mmol CH mh, respectively, with higher fluxes being detected during the middle stage of aquaculture. The temporal variation of CO and CH fluxes in both estuaries ponds closely followed the seasonal cycle of temperature. Higher CH emissions were observed in MRE ponds than in JRE ponds because of the lower water salinity and N-NO concentrations as well as a greater supply of carbon substrates. Our findings suggested that shrimp ponds were CH emission \"hotspots\" in the subtropical estuaries of China. Based on a new global warming potential model, we conservatively estimated an anuual GHG emission rate of approximately 63.68Tg CO-eq during the culture period from aquaculture ponds across the subtropical estuaries of China. Our results demonstrate the importance of aquaculture ponds as a major GHG source and a contributor to climate warming in the subtropical estuarine regions of China, and call for effective regulation of GHG emissions from these ponds for climate mitigation in future.",
        "keywords": [
            "Aquaculture pond",
            "Carbon dioxide",
            "Global warming potential",
            "Greenhouse gas fluxes",
            "Methane",
            "Salinity",
            "Subtropical estuary"
        ],
        "authors": [
            {
                "name": "Ping Yang",
                "org": "School of Geographical Sciences, Fujian Normal University, Fuzhou 350007, PR China; Key Laboratory of Humid Subtropical Eco-geographical Process of Ministry of Education, Fujian Normal University, Fuzhou 350007, PR China; Research Centre of Wetlands in Subtropical Region, Fujian Normal University, Fuzhou 350007, PR China."
            },
            {
                "name": "Yifei Zhang",
                "org": "School of Geographical Sciences, Fujian Normal University, Fuzhou 350007, PR China; Key Laboratory of Humid Subtropical Eco-geographical Process of Ministry of Education, Fujian Normal University, Fuzhou 350007, PR China."
            },
            {
                "name": "Derrick Y F Lai",
                "org": "Department of Geography and Resource Management, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China. Electronic address: dyflai@cuhk.edu.hk."
            },
            {
                "name": "Lishan Tan",
                "org": "School of Geographical Sciences, Fujian Normal University, Fuzhou 350007, PR China; Key Laboratory of Humid Subtropical Eco-geographical Process of Ministry of Education, Fujian Normal University, Fuzhou 350007, PR China."
            },
            {
                "name": "Baoshi Jin",
                "org": "School of Geographical Sciences, Fujian Normal University, Fuzhou 350007, PR China; Key Laboratory of Humid Subtropical Eco-geographical Process of Ministry of Education, Fujian Normal University, Fuzhou 350007, PR China."
            },
            {
                "name": "Chuan Tong",
                "org": "School of Geographical Sciences, Fujian Normal University, Fuzhou 350007, PR China; Key Laboratory of Humid Subtropical Eco-geographical Process of Ministry of Education, Fujian Normal University, Fuzhou 350007, PR China; Research Centre of Wetlands in Subtropical Region, Fujian Normal University, Fuzhou 350007, PR China. Electronic address: tongch@fjnu.edu.cn."
            }
        ],
        "venue": "The Science of the total environment",
        "year": 2018
    },
    "CSBg6ZRR": {
        "id": "CSBg6ZRR",
        "title": "Plot-scale spatiotemporal variations of CO 2 concentration and flux across water-air interfaces at aquaculture shrimp ponds in a subtropical estuary.",
        "abstract": "Human activities have increased anthropogenic CO emissions, which are believed to play important roles in global warming. The spatiotemporal variations of CO concentration and flux at fine spatial scales in aquaculture ponds remain unclear, particularly in China, the country with the largest aquaculture. In this study, the plot-scale spatiotemporal variations of water CO concentration and flux, both within and among ponds, were researched in shrimp ponds in Shanyutan Wetland, Min River Estuary, Southeast China. The average water CO concentration and flux across the water-air interface in the shrimp ponds over the shrimp farming period varied from 22.79\u2009\u00b1\u20090.54 to 186.66\u2009\u00b1\u20098.71\u00a0\u03bcmol\u00a0L and from -\u20090.50\u2009\u00b1\u20090.04 to 2.87\u2009\u00b1\u20090.78\u00a0mol\u00a0m\u00a0day, respectively. There was no remarkable difference in CO concentration and flux within the ponds, but significantly spatiotemporal differences in CO flux were observed between shrimp ponds. Chlorophyll a, pH, salinity, air temperature, and morphometry were the important factors driving the spatiotemporal patterns of CO flux in the shrimp ponds. Our findings highlighted the importance and spatiotemporal variations of CO flux in the important coastal ecosystems.",
        "keywords": [
            "Aquaculture ponds",
            "Carbon dioxide",
            "Plot scale",
            "Spatiotemporal variation",
            "Subtropical estuary"
        ],
        "authors": [
            {
                "name": "Yifei Zhang",
                "org": "School of Geographical Sciences, Fujian Normal University, Fuzhou, 350007, People's Republic of China."
            },
            {
                "name": "Ping Yang",
                "org": "Research Centre of Wetlands in Subtropical Region, Fujian Normal University, Fuzhou, 350007, People's Republic of China. yangping528@sina.cn."
            },
            {
                "name": "Hong Yang",
                "org": "College of Environmental Science and Engineering, Fujian Normal University, Fuzhou, 350007, People's Republic of China."
            },
            {
                "name": "Lishan Tan",
                "org": "School of Geographical Sciences, Fujian Normal University, Fuzhou, 350007, People's Republic of China."
            },
            {
                "name": "Qianqian Guo",
                "org": "School of Geographical Sciences, Fujian Normal University, Fuzhou, 350007, People's Republic of China."
            },
            {
                "name": "Guanghui Zhao",
                "org": "School of Geographical Sciences, Fujian Normal University, Fuzhou, 350007, People's Republic of China."
            },
            {
                "name": "Ling Li",
                "org": "School of Geographical Sciences, Fujian Normal University, Fuzhou, 350007, People's Republic of China."
            },
            {
                "name": "Yuchuan Gao",
                "org": "Nanping Meteorological Bureau, 12 Tiantai Road, Nanping, Fujian, 353000, People's Republic of China."
            },
            {
                "name": "Chuan Tong",
                "org": "Research Centre of Wetlands in Subtropical Region, Fujian Normal University, Fuzhou, 350007, People's Republic of China. Tongch@fjnu.edu.cn."
            }
        ],
        "venue": "Environmental science and pollution research international",
        "year": 2019
    },
    "EJuIpESx": {
        "id": "EJuIpESx",
        "title": "Methane dynamics of aquaculture shrimp ponds in two subtropical estuaries, Southeast China: Dissolved concentration, net sediment release, and water oxidation",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Ping Yang",
                "org": "Key Laboratory of Humid Subtropical Eco\u2010geographical Process of Ministry of Education, Fujian Normal University Fuzhou P.R. China"
            },
            {
                "name": "Derrick Y.F. Lai",
                "org": "Department of Geography and Resource Management and Centre for Environmental Policy and Resource ManagementThe Chinese University of Hong Kong, Shatin, New Territories Hong Kong SAR China"
            },
            {
                "name": "Hong Yang",
                "org": "College of Environmental Science and Engineering, Fujian Normal University Fuzhou China"
            },
            {
                "name": "Chuan Tong",
                "org": "Key Laboratory of Humid Subtropical Eco\u2010geographical Process of Ministry of Education, Fujian Normal University Fuzhou P.R. China"
            },
            {
                "name": "Louis Lebel",
                "org": "Unit for Social and Environmental Research, Science and Technology Research Institute, Chiang Mai University Thailand"
            },
            {
                "name": "Jiafang Huang",
                "org": "Key Laboratory of Humid Subtropical Eco\u2010geographical Process of Ministry of Education, Fujian Normal University Fuzhou P.R. China"
            },
            {
                "name": "Jin Xu",
                "org": "Key Laboratory of Humid Subtropical Eco\u2010geographical Process of Ministry of Education, Fujian Normal University Fuzhou P.R. China"
            }
        ],
        "venue": "Journal of Geophysical Research",
        "year": 2019
    },
    "LGND9O1c": {
        "id": "LGND9O1c",
        "title": "A Game Analyse on Logistics Market Structure of Agricultural Products",
        "abstract": "The logistics market structure of agricultural products requires a temporary market equilibrium,which needs a gaming between the logistics supplier and the demander.The result of the game between them argues to construct a symmetrical market structure on the base of some market centralization.",
        "keywords": [
            "market structure",
            "agricultural products logistics",
            "game model"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "College of Economics & Management,Huazhong Agricultural University,Wuhan,Hubei,"
            },
            {
                "name": "QIAO Wen",
                "org": "College of Economics & Management,Huazhong Agricultural University,Wuhan,Hubei,"
            },
            {
                "name": "YI Fa-hai",
                "org": "College of Economics & Management,Huazhong Agricultural University,Wuhan,Hubei,"
            }
        ],
        "venue": "Journal of Huazhong Agricultural University(Social Science Edition)",
        "year": 2007
    },
    "Unz2OLYN": {
        "id": "Unz2OLYN",
        "title": "The necessarian on cooperation and union of Chinese agricultural",
        "abstract": "Chinese agricultural logistics enterpriese take on the looks of high transaction cost and excessive competition,which means an institution unbalance of agricultural logistics enterprise.An small institution balance model put forwards the \"interior union\" and \"exterior cooperation\" of the agricultural logistics enterprises.As applying approaches of them,the third party logistics and supply chain based logistics can achieve the targets of specialization,scalization and socialization of agricultural products logistics.",
        "keywords": [
            "institution balance",
            "applying approaches",
            "interior union and exterior cooperation",
            "agricultural logistics enterprise"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "School of Economy and Management of Huazhong Agricultural University,Hubei ,China"
            },
            {
                "name": "QIAO Wen",
                "org": "School of Economy and Management of Huazhong Agricultural University,Hubei ,China"
            },
            {
                "name": "YI Fa-hai",
                "org": "School of Economy and Management of Huazhong Agricultural University,Hubei ,China"
            }
        ],
        "venue": "Rural Economy",
        "year": 2008
    },
    "4txPRPyn": {
        "id": "4txPRPyn",
        "title": "A Study on the Agricultural Products Valid Transportation Mode in Hubei Province\u2014\u2014Based on a Questionnaire of the Farmers in 16 Cites of Hubei",
        "abstract": "A questionnaire of the farmer agricultural product transportation in Hubei province shows that the present agricultural products mode of Hubei is ineffective. The improvement of this mode is restricted by the factors an following: decentralized farmers and decentralized agricultural products, relax relationship between farmers and processing organizations, shortage of agricultural products guild and undevelopment of agricultural products middleman. So, it requires us to put the supply chain-transportation mode in practice on the base the innovation of farmer organization.",
        "keywords": [
            "traditional mode",
            "effective mode",
            "transportation",
            "Hubei agricultural products"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": " Economics and Management School, Huazhong Agricultural University, Wuhan , China"
            },
            {
                "name": "DAI Wei",
                "org": " Humanity and Law School, Huazhong Agricultural University, Wuhan , China"
            }
        ],
        "venue": "Ecological Economy",
        "year": 2008
    },
    "hHVr9keD": {
        "id": "hHVr9keD",
        "title": "Analysis on the International Mushroom Trade Structure",
        "abstract": "The production and trade of mushroom is mainly concentrated in Asia, Europe and North America. China, Netherlands, France are the main producers as well as the exporters. The trade of canned mushroom dominates international mushroom market, and the concentration ratio of canned mushroom is very high. China and Northlands are the leading exporters of canned mushroom product. The study of international mushroom importing and exporting structure helps Chinese mushroom exporters to understand the international market conditions.",
        "keywords": [
            "Trade",
            "International market",
            "Mushroom"
        ],
        "authors": [
            {
                "name": "QIAO Wen",
                "org": ""
            },
            {
                "name": "YANG Ping",
                "org": ""
            },
            {
                "name": "YI Fa-hai",
                "org": ""
            }
        ],
        "venue": "Journal of International Trade",
        "year": 2008
    },
    "pC3hNSQS": {
        "id": "pC3hNSQS",
        "title": "A Study on the Relationship between Japan Agricultural FDI and Sino-Japan Agricultural Trade",
        "abstract": "Japan is one of the most important agricultural export markets and FDI resources to China,so analyzing the relationship between Sino-Japan agricultural trade and FDI is helpful to deepen the understanding of bilateral agricultural cooperation.The paper examines this relationship by using Granger Causality Test.The empirical results indicate that there exists a stationary complementary relationship among exports,imports,total trade and FDI;there is no Granger causality relation between FDI and agricultural exports to Japan in short or long run,but there exists one-way Granger causality relation between FDI and agricultural imports from Japan in the long run.",
        "keywords": [],
        "authors": [
            {
                "name": "Qiao Wen",
                "org": ""
            },
            {
                "name": "Yang Ping",
                "org": ""
            },
            {
                "name": "Yi Fahai",
                "org": ""
            }
        ],
        "venue": "World Economy Study",
        "year": 2008
    },
    "Go2Alrb5": {
        "id": "Go2Alrb5",
        "title": "Research progress of additives of electrolytic manganese",
        "abstract": "The present situation of the application of electrolytic manganese additive and the situation of study on additives without selenium are summarized.In the industry of electrolytic manganese,the additive of selenium always restricts the development of electrolytic manganese industrial.The development strategy of energy saving and emission reduction makes additives without selenium to be the direction of high purity electrolytic manganese development.",
        "keywords": [
            "Compound additives",
            "Additives without selenium",
            "Electrolytic manganese",
            "Prospect of development"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "School of Chemistry and Chemical Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "MAN Ruilin",
                "org": "School of Chemistry and Chemical Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "ZHAO Pengfei",
                "org": "School of Chemistry and Chemical Engineering,Central South University,Changsha ,China"
            }
        ],
        "venue": "Journal of Chemical Industry & Engineering",
        "year": 2012
    },
    "VpIz8mKW": {
        "id": "VpIz8mKW",
        "title": "Preparation of siloxane coating on surface of aluminum tube and its corrosion resistance",
        "abstract": "A siloxane coating was prepared on the surface of industrial aluminum tube by sol-gel method with vinyltriethoxysilane (KH151) and tetraethyl orthosilicate (TEOS) as precursors and by dip-coating method. The surface morphology of the siloxane coating was observed by metallographic microscope, and its corrosion resistance was studied by CuSO4 drop test, salt spray test, hydrogen evolution test, and electrochemical methods such as Tafel polarization curve and electrochemical impedance spectroscopy (EIS). The results showed that the siloxane coating is uniform, compact and level, leading to a positive shift of corrosion potential of the aluminum tube. Compared with the blank sample, the corrosion current densities of the aluminum tubes with chrome passivation film and with siloxane coating are decreased by one and two orders of magnitude, respectively. The total resistance of the siloxane coating electrode system is 6.1 times that of the blank sample and 1.48 times that of the chrome passivation film.",
        "keywords": [
            "siloxane coating",
            "aluminum tube",
            "electrochemical experiment",
            "corrosion resistance"
        ],
        "authors": [
            {
                "name": "HUANG Xiong",
                "org": " School of Chemistry and Chemical Engineering, Central South University, Changsha , China"
            },
            {
                "name": "MAN Rui-lin",
                "org": " School of Chemistry and Chemical Engineering, Central South University, Changsha , China"
            },
            {
                "name": "YIN Xiao-ying",
                "org": " School of Chemistry and Chemical Engineering, Central South University, Changsha , China"
            },
            {
                "name": "XIAO Qin",
                "org": " School of Chemistry and Chemical Engineering, Central South University, Changsha , China"
            },
            {
                "name": "YANG Ping",
                "org": " School of Chemistry and Chemical Engineering, Central South University, Changsha , China"
            }
        ],
        "venue": "Electroplating & Finishing",
        "year": 2013
    },
    "DsHwDnX5": {
        "id": "DsHwDnX5",
        "title": "Manganese Sulfate Preparation from Low-grade Oxidation Manganese Ore with Acidic Leaching",
        "abstract": "The process of leaching low-grade oxidation manganese ore in one-step to prepare manganese sulfate was investigated.In the leaching process,manganese sulfate solution used for electrolysis was prepared with sulfite as reductant,removing Fe3+ with jarosite process,and removing heavy metal ion with sulphide salt.The results show that the manganese leaching rate is 96.42% in the optimum conditions including sample ore of 10 g,sulfuric acid dosage of 6 mL,sodium sulfite dosage of 6 g,and leaching for 100 min at 90 \u2103.The leaching rate of iron is 0.02% by controlling pH value at 2.5 in the endpoint of neutralization.The qualified manganese sulfate solution was prepared by controlling pH value at 4.5 in the endpoint of de-impurity.",
        "keywords": [
            "low-grade oxidation manganese ore",
            "manganese sulfate",
            "reductive leaching",
            "jarosite process"
        ],
        "authors": [
            {
                "name": "ZHAO Peng-fei",
                "org": "School of Chemistry and Chemical Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "MAN Rui-lin",
                "org": "School of Chemistry and Chemical Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Chemistry and Chemical Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "HUANG Xiong",
                "org": "School of Chemistry and Chemical Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "LI Shan-shan",
                "org": "School of Chemistry and Chemical Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "YANG Man-yi",
                "org": "School of Chemistry and Chemical Engineering,Central South University,Changsha ,China"
            }
        ],
        "venue": "Nonferrous Metals(Extractive Metallurgy)",
        "year": 2012
    },
    "8xyDffe6": {
        "id": "8xyDffe6",
        "title": "Research Progress in Active Barite Prepared by Barite Ore",
        "abstract": "The preparation process of active barite is described in this article,which prepared by the impurity removal and whitening from barite ore.Impurity removal and whitening technology of natural barite ore is classified,and usual technologies in the barite surface modification technology and its application are reviewed,the integration idea that changing traditional direct application of barite into the barite impurity removal whitening-surface modification way is provided.It can provide an avenue for broadening the application range of barite ore,improving its economic efficiency and the preparation of new functional materials.",
        "keywords": [
            "surface modification",
            "impurity removal whitening technology",
            "research progress",
            "barite"
        ],
        "authors": [
            {
                "name": "XIAO Qin",
                "org": "Key Laboratory of Resource Chemistry of Nonferrous Metals Ministry of Education,School of Chemistry and Chemical Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "MAN Rui-lin",
                "org": "Key Laboratory of Resource Chemistry of Nonferrous Metals Ministry of Education,School of Chemistry and Chemical Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Key Laboratory of Resource Chemistry of Nonferrous Metals Ministry of Education,School of Chemistry and Chemical Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "YIN Xiao-ying",
                "org": "Key Laboratory of Resource Chemistry of Nonferrous Metals Ministry of Education,School of Chemistry and Chemical Engineering,Central South University,Changsha ,China"
            },
            {
                "name": "HUANG Xiong",
                "org": "Key Laboratory of Resource Chemistry of Nonferrous Metals Ministry of Education,School of Chemistry and Chemical Engineering,Central South University,Changsha ,China"
            }
        ],
        "venue": "Conservation and Utilization of Mineral Resources",
        "year": 2012
    },
    "Hf8ejsgJ": {
        "id": "Hf8ejsgJ",
        "title": "Surface Modification of Barite Using Sodium Dedocyl Sulfate",
        "abstract": "In this study,barite was successfully modified by sodium dedocyl sulfate(SDS).When the SDS content was 5% of the mass of barite,pH value was 3.0~3.5 and under vigorous stirring at 85 \u2103 for 30 min,the sedimentation rate and sedimentation volume in kerosene reached minimum,so did the oil adsorption,their value were 0.00967 cm3/(s\u00b7g),0.466667 cm3/g,9.5974 mL/(100g Barite),respectively,and the water contact angle of modified particles reached maximum value,indicating the surface performance of barite has changed from hydrophilicity to lipophilicity after modification,improve its dispersion and compatibility in organic materials.Finally,the FT-IR spectra of modified barite and unmodified barite proves that the SDS has combined onto the surface of modified barite.",
        "keywords": [
            "SDS barite surface modification dispersion compatibility"
        ],
        "authors": [
            {
                "name": "Xiao Qin",
                "org": "Key Laboratory of Resource Chemistry of Nonferrous Metals,Ministry of Education,School of Chemistry and Chemical Engineering,Central South University,Changsha,Hunan "
            },
            {
                "name": "Man Ruilin",
                "org": "Key Laboratory of Resource Chemistry of Nonferrous Metals,Ministry of Education,School of Chemistry and Chemical Engineering,Central South University,Changsha,Hunan "
            },
            {
                "name": "Yang Ping",
                "org": "Key Laboratory of Resource Chemistry of Nonferrous Metals,Ministry of Education,School of Chemistry and Chemical Engineering,Central South University,Changsha,Hunan "
            },
            {
                "name": "Yin Xiaoying",
                "org": "Key Laboratory of Resource Chemistry of Nonferrous Metals,Ministry of Education,School of Chemistry and Chemical Engineering,Central South University,Changsha,Hunan "
            },
            {
                "name": "Chang Wei",
                "org": "Key Laboratory of Resource Chemistry of Nonferrous Metals,Ministry of Education,School of Chemistry and Chemical Engineering,Central South University,Changsha,Hunan "
            }
        ],
        "venue": "Non-Metallic Mines",
        "year": 2013
    },
    "T7h4dCcu": {
        "id": "T7h4dCcu",
        "title": "Process of the Additives'work in Manganese Electro-deposition",
        "abstract": "In this paper,the influence of the additives NH3 and SeO2 in the process of manganese deposits on cathode have been studied.The influence of NH3 and the concentration of SeO2 on the process of manganese depositing were researched by drawing E-pH figure of electrolytic liquid system and formation of hydrogen cathode polarization curves.The results show that the electrochemical stable region of Mn2+ has been broaden due to the join of NH3,making the hydrolysis pH value of Mn2+ increase from 7.7 to 8.4,improving the competitiveness of Mn separate out on the cathode.SeO2 has been reductived to polyanionics in the cathode and adsorped in the surface of cathode,changing the part current density of the surfaces of the electrodes.It makes the electrode potential of hydrogen in the cathode negatively move to-1.35 V and gets H2 separate out more difficult.The current efficiency of Mn in the cathodic electrode position is increased from 27.5% to 75%.",
        "keywords": [
            "E-pH figure",
            "SeO2",
            "Polarization curve",
            "NH3",
            "Manganese"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "College of Chemistry and Chemical Engineering,Central South University,Changsha,Hunan ,China"
            },
            {
                "name": "MAN Ruilin",
                "org": "College of Chemistry and Chemical Engineering,Central South University,Changsha,Hunan ,China"
            },
            {
                "name": "XIAO Qin",
                "org": "College of Chemistry and Chemical Engineering,Central South University,Changsha,Hunan ,China"
            },
            {
                "name": "HUANG Xiong",
                "org": "College of Chemistry and Chemical Engineering,Central South University,Changsha,Hunan ,China"
            },
            {
                "name": "YANG Manyi",
                "org": "College of Chemistry and Chemical Engineering,Central South University,Changsha,Hunan ,China"
            }
        ],
        "venue": "China's Manganese Industry",
        "year": 2013
    },
    "TAeQ04he": {
        "id": "TAeQ04he",
        "title": "Visual analysis of extracting process of capsanthin",
        "abstract": "Capsanthin was extracted from dry and red capsicum using acetone as solvent.The uniform design method was applied to arrange the experiment.This paper used visual analysis method to analyze experimental date.The best extracting process regions for producing high quality capsanthin were found: the extraction temperature is 75~85 \u2103,the extraction time is 270~360 min,the solid-liquid ratio is 30~40 mL/g.",
        "keywords": [
            "visual analysis method",
            "capsanthin",
            "uniform design method"
        ],
        "authors": [
            {
                "name": "SONG Wen-jia",
                "org": "Key Laboratory of Functional Molecular Solid of Anhui Province,Wuhu ,China;College of Chemistry and Materials Science,Anhui Normal University,Wuhu ,China"
            },
            {
                "name": "SUN Yi-min",
                "org": "Key Laboratory of Functional Molecular Solid of Anhui Province,Wuhu ,China;College of Chemistry and Materials Science,Anhui Normal University,Wuhu ,China;Kangyongtai Biotechnology Co.,Ltd,Wuhu ,China"
            },
            {
                "name": "LUO Le",
                "org": "Key Laboratory of Functional Molecular Solid of Anhui Province,Wuhu ,China;College of Chemistry and Materials Science,Anhui Normal University,Wuhu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Key Laboratory of Functional Molecular Solid of Anhui Province,Wuhu ,China;College of Chemistry and Materials Science,Anhui Normal University,Wuhu ,China"
            },
            {
                "name": "SUN Ruo-qiong",
                "org": "College of Life Science,Anhui Normal University,Wuhu ,China"
            },
            {
                "name": "LI Qiang",
                "org": "College of Chemistry and Materials Science,Anhui Normal University,Wuhu ,China"
            }
        ],
        "venue": "Applied Chemical Industry",
        "year": 2008
    },
    "MjpLWRdj": {
        "id": "MjpLWRdj",
        "title": "Method of Molecular Dynamics Simulation and Its Application",
        "abstract": "This paper expounded the basic principle of method of molecular dynamics simulation from the aspects of force field,Newtonian equation of motion and its numerical solution,ensemble,periodic boundary condition,integration step and so on.The functions,characteristics and application of molecular dynamics simulation were analyzed and summed up.",
        "keywords": [
            "periodic boundary condition",
            "force field",
            "Newtonian equation of motion",
            "molecular dynamics simulation",
            "integration time step"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "College of Chemistry and Materials Science,Anhui Normal University,Wuhu ,China"
            },
            {
                "name": "SUN Yi-min",
                "org": "College of Chemistry and Materials Science,Anhui Normal University,Wuhu ,China"
            }
        ],
        "venue": "Journal of Anhui Normal University(Natural Science)",
        "year": 2009
    },
    "OWI4gHyJ": {
        "id": "OWI4gHyJ",
        "title": "Theoretical study of a series of p-methylcalixarene",
        "abstract": "The optimized geometric and relative energies of a series of p-methylcalixarene were studied with PM3 and molecular mechanics(MM) methods.The groups of \u2460\u2014X\u2016C\u2014(X=O\u3001S\u3001Se\u3001Te)and \u2461\u2014R\uff5cCH(R=H\u3001CH_3\u3001C_2H_5\u3001n-C_3H_7)were chosen as bridged group,respectively.When X atom is oxygen of group \u2460 the most stable structure is cone,except for oxygen atom the relative energies increase with decreasing electronegative of X atom and the most stable structure is 1,3-alternate.The relative energies of group \u2461 nearly unchanged with the R group larger,and the most stable structure is cone.",
        "keywords": [
            "PM3",
            "calixarene",
            "molecular mechanics"
        ],
        "authors": [
            {
                "name": "HUANG Yu-cheng",
                "org": "College of Chemistry and Materials Science,Anhui Normal University,Wuhu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Chemistry and Materials Science,Anhui Normal University,Wuhu ,China"
            },
            {
                "name": "CUI He",
                "org": "College of Chemistry and Materials Science,Anhui Normal University,Wuhu ,China"
            },
            {
                "name": "YE Shi-yong",
                "org": "College of Chemistry and Materials Science,Anhui Normal University,Wuhu ,China"
            }
        ],
        "venue": "Journal of Anhui Normal University(Natural Science)",
        "year": 2006
    },
    "FuoocneD": {
        "id": "FuoocneD",
        "title": "Maximum Overlap Symmetry Molecular Orbital Calculation under PM3 Approximation",
        "abstract": "A basic calculation procedure for the MOSMO method under PM3 approximation is presented in this paper and performed by using the same parameter as those used in the ordinary PM3 method.The calculated results are close to those obtained by use of PM3 method calculation and experimental data,illustrating that presented procedure is reasonable.Due to its simplicity,the presented calculation procedure may be feasible even in very large molecular systems.",
        "keywords": [
            "PM3 approximation",
            "semiemprical molecular orbital method",
            "maximum overlap symmetry molecular orbital"
        ],
        "authors": [
            {
                "name": "HUANG Rong-yi",
                "org": "College of Chemistry and Material Science,AnHui Normal University,WuHu 24100,China;School of Chemistry and Chemical Industry,Anqing Teachers College,Anqing ,China"
            },
            {
                "name": "YANG ping",
                "org": "College of Chemistry and Material Science,AnHui Normal University,WuHu 24100,China"
            },
            {
                "name": "YE Shi-yong",
                "org": "College of Chemistry and Material Science,AnHui Normal University,WuHu 24100,China"
            }
        ],
        "venue": "Journal of Anqing Teachers College(Natural Science Edition)",
        "year": 2007
    },
    "BwhccIyv": {
        "id": "BwhccIyv",
        "title": "Thermodynamic Optimization and Calculation of the HoCl_3-NaCl Binary System",
        "abstract": "Referring to the measured experimental phase diagram data and thermodynamic data,the HoCl3-NaCl phase diagram was optimized and calculated by CALPHAD technique.The Gibbs free energies of liquid phase in this system have been determined by the modified quasi-chemical model in the pair-approximation for short-range ordering.A set of thermodynamic functions of compounds Na3HoCl6,NaHoCl4,and NaHo2Cl7 have been studied on the basis of an interactive computer-assisted analysis.The optimized and calculated thermodynamic properties and phase diagrams are self-consistent.",
        "keywords": [
            "phase diagram",
            "HoCl3-NaCl",
            "modified quasi-chemical model",
            "thermodynamic property"
        ],
        "authors": [
            {
                "name": "ZHANG Ji-hong",
                "org": "College of Environmental Science,Anhui Normal University,Wuhu ,China"
            },
            {
                "name": "HU Juan",
                "org": "Anhui Key Laboratory of Functional Molecular Solids,Wuhu ,China;College of Chemistry and Materials Science,Anhui Normal University,Wuhu ,China"
            },
            {
                "name": "YAO Yong-xiang",
                "org": "Anhui Key Laboratory of Functional Molecular Solids,Wuhu ,China;College of Chemistry and Materials Science,Anhui Normal University,Wuhu ,China"
            },
            {
                "name": "GAO Tian-yi",
                "org": "Anhui Key Laboratory of Functional Molecular Solids,Wuhu ,China;College of Chemistry and Materials Science,Anhui Normal University,Wuhu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Anhui Key Laboratory of Functional Molecular Solids,Wuhu ,China;College of Chemistry and Materials Science,Anhui Normal University,Wuhu ,China"
            }
        ],
        "venue": "Journal of Anhui Normal University(Natural Science)",
        "year": 2008
    },
    "LMZGtXV5": {
        "id": "LMZGtXV5",
        "title": "The value of comprehensive staging operation for early ovarian cancer under laparoscope",
        "abstract": "[Objective] To explore the value of comprehensive staging operation for early ovarian cancer under laparoscope.[Methods] The outcomes of 64 patients with early ovarian cancer who underwent laparoscope(n=29) or laparotomy(n=35) surgical staging at Shihezi University First Hospital from May 2008 to December 2010 were retrospectively evaluated.The parameters including operation time,intraoperative blood loss,number of resected lymph nodes,postoperative morbidity,gastrointestinal recovery time,postoperative complications and hospital stay were compared between the two groups.[Result] The operation time was 125.35 min \u00b1 40.24 min for the laparoscopy group and 148.56\u00b158.13 min for the laparotomy group(P <0.05).The intraoperative blood loss was 171.25\u00b1115.86 for the laparoscopy group and 356.89\u00b1120.34 for the laparotomy group(P <0.05).The number of pelvic lymphnode resected was 20.54\u00b13.78 and 21.47\u00b12.16 for the laparoscopy group and laparotomy group,respectively(P >0.05).Compared with the laparotomy group,the laparoscopy group had short hospital stay [(9.28 \u00b1 3.56) d vs.(18.56 \u00b1 2.13) d,P <0.05],less postoperative morbidity [8 case(27.6%) vs.27 case(77.1%),P <0.05],shorter gastrointestinal recovery time [(1.5\u00b10.91) d vs.(2.7\u00b11.02) d,P <0.05] and less wound infection rate [0 case(0.0%) vs.9 case(25.7%),P <0.05].No significant difference was found in postoperative complications [3 case(10.3%) vs.5 case(14.3%)] between the two groups(P >0.05).[Conclusion] Compared with laparotomy,comprehensive staging operation for early ovarian cancer under laparoscope can achieve the same therapeutic effect,has advantages of minor trauma,fast postoperative recovery,so it is feasible and safe for early ovarian cancer.",
        "keywords": [
            "early ovarian cancer",
            "comprehensive surgical staging",
            "laparoscope"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Department of Gynecologic Oncology,the First Affiliated Hospital of Shihezi University Medical College,Shihezi,Xinjiang ,P.R.China"
            },
            {
                "name": "WANG Ying-hong",
                "org": "Department of Gynecologic Oncology,the First Affiliated Hospital of Shihezi University Medical College,Shihezi,Xinjiang ,P.R.China"
            },
            {
                "name": "LI Feng-ling",
                "org": "Department of Gynecologic Oncology,the First Affiliated Hospital of Shihezi University Medical College,Shihezi,Xinjiang ,P.R.China"
            }
        ],
        "venue": "China Journal of Endoscopy",
        "year": 2012
    },
    "hzQYlIrR": {
        "id": "hzQYlIrR",
        "title": "Clinical analysis and treatment of 92 case of complications of laparoscopic gynecologic surgery",
        "abstract": "\u3010Objective\u3011To investigate the causes,management and prevention of the complications of laparoscopic gynecologic surgery. \u3010Methods\u30112,951 Iaparoscopic gynecologic surgeries and complications were analyzed retrospectively from June 2006 to August 2009.\u3010Results\u3011Complications occurred in 92 cases,the overall complication rate was 3.12%. The complication rate of laparoscopic annex operation was the least (1.19%),the next was in the laparoscopic myomectomy (2.53%) and laparoscopically subtotal hysterectomy(LSH) (2.84%); The complication rate in total laparoscopic hysterectomy (TLH) and laparoscopic subradical or radical hysterectomy with pclvic lymphadenectomy was 5.01% and 30.38% and more than others,especially in the last. The complications included 15 case of pneumoderma,7 case of beri-operation bleeding,12 case presented viscera injury,2 case were urine retention,intestinal obstruction occurred in 4 case,5 case were abnormal of activity of lower limbs,idiopathic ascites were 2 case,there were 2 case of lymphocyst and 24 case postoperative morbidity,2 patients were amenorrhea after laparoscopic bilateral ovarian cystectomy,1 case presented vaginal stump infection and 1 case was needle lost. \u3010Conclusions\u3011With the increase of the difficulty of laparoscopic gynecologic surgery,the complications were increased. We should select indication carefully,especially in the cases which had histories of pelvic,abdominal operations and severe adhesion or more difficult operations. We should prevent and treat the complications of laparoscopic gynecologic surgery actively.",
        "keywords": [
            "complication",
            "gynecology",
            "laparoscopy"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Department of Obstetrics and Gynecology,the First Affiliated Hospital of Medical College,Shihezi University,Shihezi,Xinjiang ,P.R.China"
            },
            {
                "name": "WANG Ying-hong",
                "org": "Department of Obstetrics and Gynecology,the First Affiliated Hospital of Medical College,Shihezi University,Shihezi,Xinjiang ,P.R.China"
            }
        ],
        "venue": "China Journal of Endoscopy",
        "year": 2010
    },
    "vs26fAYQ": {
        "id": "vs26fAYQ",
        "title": "Clinical study of preserving ovarian function by laparoscopic surgery in young patients with early stage cervical squamous carcinoma",
        "abstract": "Objective:To investigate the ovarian function and the sequelae in yang women with early stage cervical squamous carcinoma undergoing radical hysterectomy,pelvic lymphadenectomy and LOT,as well as the role of neoadjuvant chemotherapy in protecting the ovarian function of cervical squamous carcinoma.Methods:22 cases under 45 years old with cervical squamous cancer were surveyed,including 19 cases undergoing radical hysterectomy, pelvic lymphadenectomy and lateral ovarian transposition(LOT) (including 9 cases undergoing neoadjuvant chemotherapy) and 3 cases whose ovarian were retained in situ.The Kupperman standard (1995) was used to investigate the climacteric syndrome,levels of FSH,LH,E2 and INHB were detected to judge ovarian function.Ultrasound was used to image the transposed ovaries to find out the sequela of LOT.Results:The female hormone levels and Kupperman score of 13 cases who underwent LOT had no difference before operation and after operation (P>0. 05) in three to six months.The levels of FSH and LH,Kupperman score in LOT and postoperation radiotherapy group were higher than those in the no radiotherapy group (P<0.05),but were significantly higher than those whose ovarian were retained in situ(P<0.05).Among 7 patients undergoing operating after neoadjuvant chemotherapy, tumor focus of 2 cases were disappeared (CR),4 cases were partial recovery (PR),1 case was no recovery (NR),the total response rate(CP+PR) was 85.7%.Among 19 LOT patients,only one case had pelvic effusion,one had intermittent slight pain in the right position where the ovarian was transposed.Conclusion:LOT is effective in retaining the ovary functions of early stage cervical squamous carcinoma patients.Pelvic radiotherapy after LOT can greatly protect the ovary function, but it also can damage the transposed ovarian partly.By neoadjuvant chemotherapy,retaining ovarian function is possible in partly patients with advanced cervical squamous carcinoma,so neoadjuvant chemotherapy should be promoted;the rate of sequelae after LOT is very low.",
        "keywords": [
            "Ovarian endocrine function",
            "Neoadjuvant chemotherapy",
            "Ovarian transposition",
            "Cervical squamous cell carcinoma",
            "Sequelae"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": ".Department of Obstetrics and Gynecology,Medical College,The First Affiliated Hospital of Shihezi University, Shihezi ,Xinjiang,China"
            },
            {
                "name": "WANG Ying-Hong",
                "org": ".Department of Obstetrics and Gynecology,Medical College,The First Affiliated Hospital of Shihezi University, Shihezi ,Xinjiang,China"
            }
        ],
        "venue": "Maternal and Child Health Care of China",
        "year": 2009
    },
    "o8fHL8qS": {
        "id": "o8fHL8qS",
        "title": "Values of pregnancy associated plasma protein-A and progesterone levels in early diagnosis of ectopic pregnancy and missed abortion",
        "abstract": "Objective:To explore the value of serum progesterone and pregnancy associated plasma protein-A(PAPP-A) in early diagnosis of ectopic pregnancy and missed abortion.Methods:40 cases with early intrauterine pregnancy,40 cases with ectopic pregnancy and 20 cases with missed abortion were selected,their serum levels of progesterone and PAPP-A were detected by ELISA.Results:The serum levels of progesterone and PAPP-A in ectopic pregnancy group and missed abortion group were significantly lower than those in early intrauterine pregnancy group(P<0.05),but there was no significant difference between ectopic pregnancy group and missed abortion group(P>0.05);at the same gestational weeks,the serum level of PAPP-A in early intrauterine pregnancy group was significantly higher than that in ectopic pregnancy group(P<0.05).Conclusion:The detection of serum progesterone and PAPP-A is helpful for early diagnosis of ectopic pregnancy and missed abortion.",
        "keywords": [
            "Progesterone",
            "Missed abortion",
            "Ectopic pregnancy",
            "Pregnancy associated plasma protein-A"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": ".Department of Gynecology and Obstetrics,the First Affiliated Hospital of Medical College,Shihezi University,Shihezi ,Xinjiang,China"
            },
            {
                "name": "WANG Ying-Hong",
                "org": ".Department of Gynecology and Obstetrics,the First Affiliated Hospital of Medical College,Shihezi University,Shihezi ,Xinjiang,China"
            }
        ],
        "venue": "Maternal and Child Health Care of China",
        "year": 2010
    },
    "8ygRAIXf": {
        "id": "8ygRAIXf",
        "title": "The effect of two suture ways on vaginal stump bleeding by laparoscopic total hysterectomy",
        "abstract": "Objective: To compare the effect of two suture methods of vaginal stump on laparoscopic hysterectomy cutting stump bleeding and explore the advantages and disadvantages of the two ways of stump suture.Methods:296 cases of laparoscopic hysterectomy patients who were admitted in our hospital from January 2008 to December 2012 and were going to be treated with laparoscopic hysterectomy were randomly divided into continuous suture(control group) and \"8\" suture(experimental group),the incidence rate of stump bleeding was compared between the two groups.296 cases were also divided into malignant group and benign group,the incidence rates of stump bleeding were also compared.Results:\u2460No significant difference of the incidence rate of vaginal stump bleeding was found between continuous suture group and \"8\" suture group(P>0.05);\u2461The incidence rate of vaginal stump bleeding in malignant group was significantly higher than that in the benign group(P<0.01).Conclusion:Vaginal bleeding stump after laparoscopic hysterectomy was related to the nature of the underlying diseases but had nothing to do with the stump suture.",
        "keywords": [
            "Laparoscopic total hysterectomy",
            "Vaginal stump \"8\" suture",
            "Continuous suture of vaginal stump",
            "Vaginal bleeding stump"
        ],
        "authors": [
            {
                "name": "FU Rui-ting",
                "org": "Gynecology and Obstetrics Department,First Affiliated Hospital of Shihezi University School of Medicine,Xinjiang Shihezi,"
            },
            {
                "name": "WANG Ying-hong",
                "org": "Gynecology and Obstetrics Department,First Affiliated Hospital of Shihezi University School of Medicine,Xinjiang Shihezi,"
            },
            {
                "name": "GUO Xiao-qing",
                "org": "Gynecology and Obstetrics Department,First Affiliated Hospital of Shihezi University School of Medicine,Xinjiang Shihezi,"
            },
            {
                "name": "YANG Ping",
                "org": "Gynecology and Obstetrics Department,First Affiliated Hospital of Shihezi University School of Medicine,Xinjiang Shihezi,"
            },
            {
                "name": "ZHANG Yu",
                "org": "Gynecology and Obstetrics Department,First Affiliated Hospital of Shihezi University School of Medicine,Xinjiang Shihezi,"
            }
        ],
        "venue": "Journal of Nongken Medicine",
        "year": 2012
    },
    "EwvhDyMn": {
        "id": "EwvhDyMn",
        "title": "Effects of pseudo CO_2 pneumoperitoneum on the capability of adhesion and invasion on cervical carcinoma cells",
        "abstract": "Objective:To investigate the effects of pseudo CO2 pneumoperitoneum on the capability of adhesion and invasion on cervical carcinoma Hela cells.Methods:The cervical carcinoma Hela cells were exposed to simulated CO2 pneumoperitoneum environment for 4h under the pressure of 12 mmHg and those cultured in normal experimental condition as control.The cell growth changes were detected by MTT.The cell matrix adhesions were detected by Matrigel test.The protein expression of E-cadherin and matrix metalloproteinase-9(MMP-9) were examined by immunocytochemistry method.Results:Compared with the control group,the proliferation and the cell matrix adhension ability increased significantly in the treated group(P<0.05).At the same time,the expression of E-cadherin was lower in treated cells and the expression of MMP-9 was higher than that in the control group(P<0.05).Conclusion:Carbon dioxide pneumoperitoneum environment increases the risk of adhesion and invasion in cervical carcinoma.One of the mechanisms may be associated with the decrease of E-cadherin and increase of MMP-9.",
        "keywords": [
            "CO2 pneumoperitoneum",
            "Cervical carcinoma",
            "Matrix metalloproteinase-9",
            "E-cadherin",
            "Cell adhesion"
        ],
        "authors": [
            {
                "name": "LI Feng-Ling",
                "org": ".Department of Obstetrics and Gynecology,The First Affiliated Hospital,Medical College of Shihezi University,Shihezi ,Xinjiang,China"
            },
            {
                "name": "WANG Ying-Hong",
                "org": ".Department of Obstetrics and Gynecology,The First Affiliated Hospital,Medical College of Shihezi University,Shihezi ,Xinjiang,China"
            },
            {
                "name": "Yang Ping",
                "org": ".Department of Obstetrics and Gynecology,The First Affiliated Hospital,Medical College of Shihezi University,Shihezi ,Xinjiang,China"
            }
        ],
        "venue": "Maternal and Child Health Care of China",
        "year": 2011
    },
    "JvetFhcX": {
        "id": "JvetFhcX",
        "title": "Effect of siRNA interruption of CD40-CD40L interaction on the atherosclerotic plaque in ApoE~(-/-)mice",
        "abstract": "Objective: To investigate the effect of interruption of CD40-CD40L interaction on the atherosclerotic plaque in ApoE-/-mice.Methods: Carotid atherosclerotic lesions model was rapidly induced by perivascular collar placement in ApoE-/-.The ApoE-/-mice were treated with anti-CD40L antibody and high effective siRNACD40 lentivirus respectively.The atherosclerotic plaques were detected by hematoxylin and eosin-stained after 4 weeks.Results: Compared with the experimental and control,atherosclerotic plaques areas of ApoE-/-mice were decreased by 48.3% and 58.6% in anti-CD40L antibody and siRNACD40 groups respectively.Conclusion: The high effective siRNACD40 can significant depressed the formation of atherosclerotic plaques through interruption of CD40-CD40L interaction in ApoE-/-mice.",
        "keywords": [
            "mice",
            "RNA interfering",
            "atherosclerosis",
            "CD40"
        ],
        "authors": [
            {
                "name": "YAN Jin-chuan",
                "org": "Department of Cardiology,the Affiliated Hospital of Jiangsu University,Zhenjiang Jiangsu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Cardiology,the Affiliated Hospital of Jiangsu University,Zhenjiang Jiangsu ,China"
            },
            {
                "name": "XU Liang-jie",
                "org": "Department of Cardiology,the Affiliated Hospital of Jiangsu University,Zhenjiang Jiangsu ,China"
            },
            {
                "name": "WANG Biao",
                "org": "Department of Cardiology,the Affiliated Hospital of Jiangsu University,Zhenjiang Jiangsu ,China"
            },
            {
                "name": "YUAN Wei",
                "org": "Department of Cardiology,the Affiliated Hospital of Jiangsu University,Zhenjiang Jiangsu ,China"
            }
        ],
        "venue": "Journal of Jiangsu University(Medicine Edition)",
        "year": 2010
    },
    "leZnVGX7": {
        "id": "leZnVGX7",
        "title": "The clinical implications of increased coexpression of pregnancy associated plasma protein-A and OX40 ligand in patients with acute coronary syndromes",
        "abstract": "Objective:To investigate whether PAPP-A level was related to serum OX40 ligand (OX40L) level or membrane-bound OX40L level in patients with ACS.Method:All patients underwent coronary angiography in our study.Overall,30 normal controls,60 patients with stable angina (SA) and 80 patients with acute coronary syndromes (ACS),including unstable angina (UA) (n=50) and acute myocardial infarction (AMI) (n=30) were enrolled in current study.Serum PAPP-A and soluble OX40L (sOX40L) were measured by ELISA whereas the expression of OX40L on monocytes were analyzed with flow cytometry.Result:The expression of OX40L in peripheral monocytes in patients with UA [25.6\u00b15.5 mean fluorescence intensity (MFI)] and AMI (29.4\u00b16.3 MFI) were significantly higher than those in patients with SA (10.6\u00b12.8 MFI) and controls (11.1\u00b13.5 MFI) (P<0.001).Both sOX40L and PAPP-A in patients with UA (15.7\u00b1 4.9 \u03bcg/L,25.4\u00b16.8 mg/L,respectively) and AMI (17.1\u00b15.3 \u03bcg/L,26.3\u00b15.6 mg/L,respectively) were significantly higher than those in patients with SA (3.4\u00b11.4 \u03bcg/L,9.6\u00b12.1 mg/L,respectively) and controls (3.9 \u00b1 1.3 \u03bcg/L,8.5\u00b12.8 mg/L,respectively) (P<0.001).It was interesting that a positive correlation was found between sOX40L,membrane-bound OX40L and serum PAPP-A levels (r1=0.54,r2=51;P<0.0001).PAPP-A levels,serum and membrane-bound OX40L were all significantly correlated with complex coronary stenosis(r1=0.40,r2=0.56,r3=0.55,P<0.001).Conclusion:PAPP-A level was related to OX40L in serum and membrane-bound in patients with ACS.Enhanced level of serum PAPP-A and sOX40L may represent markers for coronary disease activity.",
        "keywords": [
            "OX40 ligand",
            "pregnancy associated plasma protein-A",
            "acute coronary syndromes"
        ],
        "authors": [
            {
                "name": "LIU Peijing",
                "org": "Department of Cardiology,Affiliated hospital of Jiangsu University,Zhenjiang,,China"
            },
            {
                "name": "YAN Jinchuan",
                "org": "Department of Cardiology,Affiliated hospital of Jiangsu University,Zhenjiang,,China"
            },
            {
                "name": "WANG Cuiping",
                "org": "Department of Cardiology,Affiliated hospital of Jiangsu University,Zhenjiang,,China"
            },
            {
                "name": "CHEN Guanghua",
                "org": "Department of Cardiology,Affiliated hospital of Jiangsu University,Zhenjiang,,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Cardiology,Affiliated hospital of Jiangsu University,Zhenjiang,,China"
            },
            {
                "name": "WANG Yi",
                "org": "Department of Cardiology,Affiliated hospital of Jiangsu University,Zhenjiang,,China"
            },
            {
                "name": "REN Guoqing",
                "org": "Department of Cardiology,Affiliated hospital of Jiangsu University,Zhenjiang,,China"
            }
        ],
        "venue": "Journal of Clinical Cardiology",
        "year": 2010
    },
    "Z0I2w7Tz": {
        "id": "Z0I2w7Tz",
        "title": "Effect of siRNA interruption of CD40-CD40L interaction on the function of platelets in ApoE~(-/-)",
        "abstract": "Objective:To investigate the effect of interruption of CD40-CD40L interaction by CD40-RNAi on the function of platelets in ApoE-/-.Method:ApoE-/-mice were randomly divided into three groups,anti-CD40 ligand group,CD40-RNAi group and control group.The P-selectin(CD62P) and monocyte-platelet aggregate were determined by flow cytometry.Result:The expression of CD62P on platelets was significantly decreased in anti-CD40 ligand(15.6\u00b13.3,MFI) and CD40-RNAi group(10.7\u00b12.7,MFI) compared with control(21.8\u00b13.6,MFI).The monocyte-platelet aggregate was also decreased in anti-CD40 ligand(11.2\u00b12.3%) and CD40-RNAigroup(6.2\u00b12.7%).The expression of CD40 on platelets showed a significant difference before(67.3\u00b111.3,MFI) and after(6.5\u00b11.9,MFI) treated with CD40-RNAi in ApoE-/-mice.Conclusion:CD40-RNAi can significant depressed the function of platelets through interruption of CD40-CD40L interaction in ApoE-/-mice.",
        "keywords": [
            "platelet",
            "RNA interfering",
            "CD40",
            "atherosclerosis"
        ],
        "authors": [
            {
                "name": "YAN Jinchuan",
                "org": "Department of Cardiology,Affiliated Hospital of JiangSu University,Zhenjiang,Jiangsu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Cardiology,Affiliated Hospital of JiangSu University,Zhenjiang,Jiangsu ,China"
            },
            {
                "name": "XU Liangjie",
                "org": "Department of Cardiology,Affiliated Hospital of JiangSu University,Zhenjiang,Jiangsu ,China"
            },
            {
                "name": "WANG Biao",
                "org": "Department of Cardiology,Affiliated Hospital of JiangSu University,Zhenjiang,Jiangsu ,China"
            }
        ],
        "venue": "Journal of Clinical Cardiology",
        "year": 2011
    },
    "WJkvIUGs": {
        "id": "WJkvIUGs",
        "title": "Effect of highly effective selection of mouse CD40 small interference  RNA and on the expression of CD40 in mouse lymphocytes",
        "abstract": "Objective: To select highly effective mouse CD40 small interfering RNA(siRNA)by the technology of interfering RNA.Methods: Three specific chemically synthesized siRNAs targeting on CD40 of mouse were designed and were transfected into lymphocytes with Lipofectamine RNAiMAX via reverse transfection,while nonspecific siRNA and untreated cell served as the control separately,The expression of CD40 and CD40 mRNA in lymphocytes were measured by flow cytometry and real-time fluorogenic quantitative PCR(RFQ-PCR) respectively after 24 h of transfection.The expression of CD40 protein levels were assessed by Western blot after 48 h of transfection.Results: Compared with the experimental and controls,siRNA group showed significantly down-regulation of CD40 mRNA and protein in lymphocytes.The total inhibitory rate of CD40 expression for siCD40-1,siCD40-2,siCD40-3 were 69%,78% and 41% respectively.There was no significant difference found in controls.Conclusion: siRNA of CD40 could specifically down-regulate the expression of CD40 mRNA and protein in mouse lymphocytes.siRNA-2 has the highly effective inhibition.",
        "keywords": [
            "lymphocytes",
            "reverse transfection",
            "CD40",
            "small interfering RNA(siRNA)"
        ],
        "authors": [
            {
                "name": "YAN Jin-chuan",
                "org": "Department of Cardiology,the Affiliated Hospital of Jiangsu University,Zhenjiang Jiangsu ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Cardiology,the Affiliated Hospital of Jiangsu University,Zhenjiang Jiangsu ,China"
            },
            {
                "name": "GONG Jie",
                "org": "Department of Cardiology,the Affiliated Hospital of Jiangsu University,Zhenjiang Jiangsu ,China"
            },
            {
                "name": "WANG Biao",
                "org": "Department of Cardiology,the Affiliated Hospital of Jiangsu University,Zhenjiang Jiangsu ,China"
            },
            {
                "name": "XU Liang-jie",
                "org": "Department of Cardiology,the Affiliated Hospital of Jiangsu University,Zhenjiang Jiangsu ,China"
            }
        ],
        "venue": "Journal of Jiangsu University(Medicine Edition)",
        "year": 2010
    },
    "V1Q61mJq": {
        "id": "V1Q61mJq",
        "title": "Clinical implications of increased CD40 ligand expression in patients with chronic heart failure",
        "abstract": "Objective To investigate the clinical implications of increased CD40 ligand(CD40L) expression in patients with chronic heart failure(CHF).Methods Thirty normal controls and 140 patients with CHF were studied.The expression of CD40L on platelets was analyzed by indirect-immunofluorescence flow cytometry,and the serum soluble CD40L(sCD40L) level was detected by ELISA.Brain natriuretic peptide(BNP) was measured by radioimmunoassay.Results The patients with CHF showed a significantly increased expression of CD40L[(39.4\u00b113.7)MFI] on platelets and serum sCD40L levels [(23.8\u00b18.7)ng/ml].CD40L expression on platelets and serum sCD40L levels were positively correlated with New York Heart Association(NYHA) functional class,left ventricular ejection fraction and BNP levels in CHF.Conclussion The findings suggest that CHF patients showed upregulation in the expression of CD40L system,which may create a pathogenic role in the development and progression of CHF.",
        "keywords": [
            "Brain natriuretic peptide",
            "CD40 ligand",
            "Chronic heart failure"
        ],
        "authors": [
            {
                "name": "YAN Jinchuan",
                "org": ",et al.Department of Cardiology,Affiliated Hospital,Jiangsu University,Zhenjiang , CHINA"
            },
            {
                "name": "WANG Cuiping",
                "org": ",et al.Department of Cardiology,Affiliated Hospital,Jiangsu University,Zhenjiang , CHINA"
            },
            {
                "name": "YANG Ping",
                "org": ",et al.Department of Cardiology,Affiliated Hospital,Jiangsu University,Zhenjiang , CHINA"
            }
        ],
        "venue": "Jiangsu Medical Journal",
        "year": 2009
    },
    "FRkRsL8d": {
        "id": "FRkRsL8d",
        "title": "Effect of interruption of CD40-CD40 ligand interaction induced by CD40siRNA on proliferation and migration in cultured human umbilical vein endothelial cells",
        "abstract": "Objective To investigate the effect of CD40 siRNA interruption of CD40-CD40 ligand interaction on the proliferation and migration in cultured human umbilical vein endothelial cells.Methods Endothelial cells were isolated from human umbilical vein by collagenase solution.The incorporation of 3H-TdR and 3H-Leu analysis were used to evaluate the cell proliferation.Cells migration was observed by monolayer cell scrape and reverse microscope.Results The incorporation of 3H-TdR and 3H-Leu and the migration of endothelial cells were significantly raised by CD40L.CD40 siRNA significantly suppressed CD40L-induced incorporation of 3H-TdR,3H-Leu and the migration of HUVEC in a dose-dependent manner.Moreover,the best pre-treated time for CD40 siRNA was 48 hours.Conclusion CD40 siRNA can significantly suppress the proliferation and migration of cultured human endothelial cells induced by CD40-CD40L interaction.",
        "keywords": [
            "Endothelial cells",
            "Small interfering RNA",
            "CD40 ligand"
        ],
        "authors": [
            {
                "name": "YAN Jinchuan",
                "org": ",et al.Department of Cardiology,Affiliated Hospital,Jiangsu University,Zhenjiang ,CHINA"
            },
            {
                "name": "XU Liangjie",
                "org": ",et al.Department of Cardiology,Affiliated Hospital,Jiangsu University,Zhenjiang ,CHINA"
            },
            {
                "name": "YANG Ping",
                "org": ",et al.Department of Cardiology,Affiliated Hospital,Jiangsu University,Zhenjiang ,CHINA"
            }
        ],
        "venue": "Jiangsu Medical Journal",
        "year": 2010
    },
    "LZo9ZabS": {
        "id": "LZo9ZabS",
        "title": "The clinical implications of increased CD40 ligand expression in patients with chronic heart failure",
        "abstract": "Objective To investigate whether CD40 ligand(CD40L) expression was disordered and the correlation between CD40 ligand and brain natriuretic peptide(BNP) in patients with chronic heart failure(CHF).Methods Thirty normal controls and 140 patients with CHF were observed.The expression of CD40L of platelets was analyzed by indirect-immunofluorescence flow cytometry,and the serum soluble CD40L(sCD40L) level was detected by a commercially available enzyme-linked immunosorbent assay(ELISA).BNP was measured by radioimmunoassay.Results Our results provided that patients with CHF showed a significant increased expression of CD40L[(39.4\u00b113.7)MFI] of platelets and sCD40L levels[(23.8\u00b18.7)ng\u00b7ml-1 ].CD40L expression of platelets and sCD40L levels significant positively correlated with New York Heart Association(NYHA) functional class and BNP levels in patients with CHF.But it negatively correlated with left ventricular ejection fraction(LVEF).Conclussions The patients with CHF show upregulation expression of CD40L system,which may create a pathogenic role in the development and progression of CHF.",
        "keywords": [
            "left ventricular ejection fraction",
            "CD40 ligand",
            "brain natriuretic peptide",
            "heart failure",
            "cardiac function"
        ],
        "authors": [
            {
                "name": "YAN Jin-chuan",
                "org": "Department of Cardiology,the Hospital Affiliated to Jiangsu University,Zhenjiang ,China"
            },
            {
                "name": "WANG Cui-ping",
                "org": "Department of Cardiology,the Hospital Affiliated to Jiangsu University,Zhenjiang ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Cardiology,the Hospital Affiliated to Jiangsu University,Zhenjiang ,China"
            },
            {
                "name": "CHEN Guang-hua",
                "org": "Department of Cardiology,the Hospital Affiliated to Jiangsu University,Zhenjiang ,China"
            },
            {
                "name": "LIU Pei-jing",
                "org": "Department of Cardiology,the Hospital Affiliated to Jiangsu University,Zhenjiang ,China"
            },
            {
                "name": "DU Rong-zeng",
                "org": "Department of Cardiology,the Hospital Affiliated to Jiangsu University,Zhenjiang ,China"
            },
            {
                "name": "ZHAO Jian-wei",
                "org": "Department of Cardiology,the Hospital Affiliated to Jiangsu University,Zhenjiang ,China"
            }
        ],
        "venue": "Modern Medical Journal",
        "year": 2008
    },
    "F8RSGllV": {
        "id": "F8RSGllV",
        "title": "Effect of Different Hormones on Rooting and Tissue Culture of Rosa chinensis Stem",
        "abstract": "Using the stem of Rosa chinensis as experimental material,the effects of ABT and IBA concentration on its rooting,and 6-BA,NAA,GA3 concentration on the tissue culture were studied.The results showed that when 50 mg/L ABT or 100 mg/L IBA was added into MS,the rooting of stem cutting was relatively high,and the roots grew well.MS+0.5 mg/L 6-BA+0.3 mg/L NAA was the optimal medium for adventitious bud induction;MS+1.0mg/L GA3 was the optimal medium for adventitious bud growth.",
        "keywords": [
            "proliferation",
            "Rosa chinensis",
            "bud",
            "tissue culture"
        ],
        "authors": [
            {
                "name": "XU Qiu-yan",
                "org": "School of Biochemical and Environmental Engineering,Nanjing Xiaozhuang College,Nanjing ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Biochemical and Environmental Engineering,Nanjing Xiaozhuang College,Nanjing ,China"
            },
            {
                "name": "ZHANG Bian-jiang",
                "org": "School of Biochemical and Environmental Engineering,Nanjing Xiaozhuang College,Nanjing ,China"
            }
        ],
        "venue": "Hubei Agricultural Sciences",
        "year": 2012
    },
    "FiSxHDww": {
        "id": "FiSxHDww",
        "title": "Research of AtNHX1 Gene Transformation in Brassica napus L. by Agrobacterium tumefaciens",
        "abstract": "[Objective] The aim was to investigate AtNHX1 gene transformation in Brassica napus L. mediated by Agrobacterium tumefaciens. [Method] By using Agrobacterium-mediated method and cre/lox plant expression vector,the transformation of AtNHX1 gene of Na+/H+ antiporter in Brassica napus was studied. [Result] The regeneration rate of cotyledon with petiole was much higher than that of hypocotyl,thus,the cotyledon with petiole was selected as the recipient for transformation. After the cotyledon with petiole was soaked in bacterial solution (OD600=0.4) for 8-10 min,kanamycin-resistant green seeding percentage could reach 3.75%. [Conclusion] The PCR detection of kanamycin-resistant plants proved that NHX1 gene had been inserted into Brassica napus genome. And this research could provide a new way to improve the salt tolerance of Brassica napus.",
        "keywords": [
            "Gene transformation",
            "Brassica napus",
            "Na+/H+ antiporter gene",
            "Cotyledon with petiole"
        ],
        "authors": [
            {
                "name": "XU Pei-feng",
                "org": " Department of Life Sciences,Nanjing Xiaozhuang University,Nanjing "
            },
            {
                "name": "DONG Jing",
                "org": " Department of Life Sciences,Nanjing Xiaozhuang University,Nanjing "
            },
            {
                "name": "JI Yan-qiu",
                "org": " Department of Life Sciences,Nanjing Xiaozhuang University,Nanjing "
            },
            {
                "name": "YANG Ping",
                "org": " Department of Life Sciences,Nanjing Xiaozhuang University,Nanjing "
            },
            {
                "name": "CAI Xiao-ning",
                "org": " Department of Life Sciences,Nanjing Xiaozhuang University,Nanjing "
            },
            {
                "name": "PU Hui-ming",
                "org": " Jiangsu Academy of Agricultural Sciences,Nanjing "
            }
        ],
        "venue": "\u519c\u4e1a\u79d1\u5b66\u4e0e\u6280\u672f(\u82f1\u6587\u7248)",
        "year": 2010
    },
    "luiWqkV0": {
        "id": "luiWqkV0",
        "title": "A Study on Nutritional Components and Effective Constituents in Elite Strain of Atractylodes Macracephala Koidz",
        "abstract": "An analysis was made on the agronomic characteristics,water,fiber,proteins,amino acids,total saccharide and Atractylenolide in the root of Atractylodes macracephala Koidz.The results indicated that the selected D88 elite strain showed typical characters of polyploid plant,the root yields(crude drug) of D88 strain increased greatly compared with CK.There were at least 15 kinds of amino acids in D88 and CK of A.macracephala Koidz.,and the three highest kinds of amino acids were Asp,Arg and Pro,accounting for 71.7%(CK) and 63.5 %(D88) respectively among the total amino acids.Compared with CK,D88 strain showed much higher content and productivity of atractylenolides I,\u2161 and III.Obtained results indicate a good prospect to further develop excellent varieties with high yields and high contents of effective constituents of A.macracephala Koidz.",
        "keywords": [
            "agronomic characteristics",
            "nutritional components",
            "effective constituents",
            "autotetraploid",
            "Atractylodes macracephala Koidz"
        ],
        "authors": [
            {
                "name": "TANG Ning",
                "org": "School of Biochemistry and Environmental Engineering,Nanjing Xiaozhuang University,Nanjing ,Jiangsu"
            },
            {
                "name": "ZHANG Bian-jiang",
                "org": "School of Biochemistry and Environmental Engineering,Nanjing Xiaozhuang University,Nanjing ,Jiangsu"
            },
            {
                "name": "HUA Chun",
                "org": "School of Biochemistry and Environmental Engineering,Nanjing Xiaozhuang University,Nanjing ,Jiangsu"
            },
            {
                "name": "ZHANG Dun-lin",
                "org": "School of Biochemistry and Environmental Engineering,Nanjing Xiaozhuang University,Nanjing ,Jiangsu"
            },
            {
                "name": "YANG Ping",
                "org": "School of Biochemistry and Environmental Engineering,Nanjing Xiaozhuang University,Nanjing ,Jiangsu"
            }
        ],
        "venue": "Journal of Nanjing Xiaozhuang University",
        "year": 2010
    },
    "FfFKu9qw": {
        "id": "FfFKu9qw",
        "title": "Research on the Introduction and Cultivation of Hypericum perforatum in Nanjing",
        "abstract": "Comparative study on the development of Hypericum perforatum introduced from 13 samples in Southeast of China in Nanjing area of Jiangsu Province during 2000\uff5e2007. The germination percentage, the character of stem, leaf and flowers of theses plants were observed. The results of comparative analyses of morphology and component show that the biological characters of introduced H. perforatum are kept. Studies on different ways of planting, cultivation and management of these H. perforatum in Nanjing were also discussed.",
        "keywords": [
            "Nanjing",
            "introduction and cultivation",
            "Hypercicum perforatum"
        ],
        "authors": [
            {
                "name": "SONG Dong-jie",
                "org": "Department of Life Science, Nanjing Xiaozhuang University, Nanjing , China"
            },
            {
                "name": "CHEN Quan-zhan",
                "org": "Department of Life Science, Nanjing Xiaozhuang University, Nanjing , China"
            },
            {
                "name": "REN Yuan-hao",
                "org": "Department of Life Science, Nanjing Xiaozhuang University, Nanjing , China"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Life Science, Nanjing Xiaozhuang University, Nanjing , China"
            },
            {
                "name": "SHEN Jian",
                "org": "College of Horticulture, Jinling Institute of Technology, Nanjing , China"
            },
            {
                "name": "QIN Chun",
                "org": "College of Life Science, Nanjing Agricultural University, Nanjing , China"
            }
        ],
        "venue": "Hubei Agricultural Sciences",
        "year": 2009
    },
    "0kFUamKA": {
        "id": "0kFUamKA",
        "title": "Characterization of Codon Usage of \u03b2-amylase Genes in Arabidopsis Thaliana",
        "abstract": "This paper examined the homology of 9\u03b2-amylase genes(BAM1\u2015BAM9) of Arabidopsis thaliana at the cDNA and protein levels,which were calculated by DNAMAN.It also investigated the codon usage bias of \u03b2-amylase genes in Arabidopsis thaliana characterized by the parameters GC content,GC content at each site of synonymous codon(GC1-3s) and the effective number of codon(Enc).The results showed that the homologies of 9 genes were obviously variable,ranging from 41.6% to 64.2% at the cDNA level and from 29.4% to 62.6% at the protein level,with BAM5 and BAM6 representing the highest homology.",
        "keywords": [
            "Arabidopsis thaliana",
            "homology",
            "\u03b2-amylase"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "School of Biochemical and Environmental Engineering,Nanjing Xiaozhuang University,Nanjing ,Jiangsu"
            }
        ],
        "venue": "Journal of Nanjing Xiaozhuang University",
        "year": 2011
    },
    "jaby4Zeq": {
        "id": "jaby4Zeq",
        "title": "Bioinformatic Analysis of ATPase E Like Gene from Thellungiella Halophila",
        "abstract": "The properties of ATPase E Like gene encoding protein such as the constitution of amino acid,equipotential,domain,characteristic spots,secondary structure in Thellungiella halophila were analyzed by a series of bioinformatics software.The results showed that this protein was unstable,and the formula was C1132H1867N325O349S9.The secondary structure was primarily composed of Alpha helix.A certain difference does exist in Thellungiella halophila ATPase E Like protein and Arabidopsis thaliana ATPase E1,E2,and E3.",
        "keywords": [
            "ATPase E Like gene",
            "Arabidopsis thaliana",
            "bioinformatics",
            "Thellungiella halophila"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Dept of Life Science,Nanjing Xiaozhuang University,Nanjing ,China"
            },
            {
                "name": "ZHAO Ling-ling",
                "org": "Nanjing Hongshan Zoo,Nanjing ,China"
            }
        ],
        "venue": "Journal of Nanjing Xiaozhuang University",
        "year": 2008
    },
    "oZC0tMdo": {
        "id": "oZC0tMdo",
        "title": "Bioinformatic Analysis of PEPC in C_3 and C_4 Plants",
        "abstract": "To explore the functional differences between C3 and C4 PEPC,PEPC proteins of four different C3 and C4 plants were analyzed by various bioinformatic tools to predict the protein properties,such as amino acids composition,pI,domains,secondary and spatial structure;and the PEPC protein sequences of C3 and C4 plants were aligned.The results showed that the PEPC proteins were unstable and the secondary structures were mainly composed of random coil,indicating some differences between PEPCs of C3 and C4 plants.A highly homologous(99.7%) protein structure data 1JQO chain A was predicted by three-dimensional structure modeling of PEPC by ESyPred3D,thus facilitated the tertiary structure building of target sequence.The tertiary structure model of Zea mays PEPC was further checked by PROCHECK programmer,and showed that 94.2% of the amino acid residues were located in the most favored regions in Ramachandran plot,indicating that the simulated three-dimensional structure of Zea mays PEPC was reliable.",
        "keywords": [
            "PEPC",
            "C3 plant",
            "C4 plant",
            "bioinformatics"
        ],
        "authors": [
            {
                "name": "WU Mei",
                "org": "College of Biochemistry and Enviromental Engineering,Nanjing Xiaozhuang University,Nanjing ,China;College of Life Science,Anhui Agriculture University,Hefei ,China"
            },
            {
                "name": "ZHANG Bian-jiang",
                "org": "College of Biochemistry and Enviromental Engineering,Nanjing Xiaozhuang University,Nanjing ,China"
            },
            {
                "name": "YANG Ping",
                "org": "College of Biochemistry and Enviromental Engineering,Nanjing Xiaozhuang University,Nanjing ,China"
            },
            {
                "name": "WANG Rong-fu",
                "org": "College of Life Science,Anhui Agriculture University,Hefei ,China"
            },
            {
                "name": "CHEN Quan-zhan",
                "org": "College of Biochemistry and Enviromental Engineering,Nanjing Xiaozhuang University,Nanjing ,China"
            }
        ],
        "venue": "Hubei Agricultural Sciences",
        "year": 2011
    },
    "cjCS0WIU": {
        "id": "cjCS0WIU",
        "title": "Characterization of Codon Usage of Plant KCO Genes",
        "abstract": "Codons of 75 K+ channel outward-rectif ier(KCO) genes from plant were studied.CodonW software was used to calculate different parameters for the codon usage.The codon usage bias in plant KCO genes was analyzed to f ind the factors affecting the formation of codon bias.The result indicated that nucleotide composition(r=0.961,P<0.01) and natural selection(r=0.568,P<0.01) were the main factors on the codon usage of plant KCO genes.Moreover,the highly expressed genes had a stronger codon bias of the G or C at the third position of codons.We def ined 26 codons end with G/C such as UUC and CUC as the optimal codons in plant KCO genes.",
        "keywords": [
            "codon usage bias",
            "KCO genes",
            "natural selection"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "School of Biochemical and Environmental Engineering,Nanjing Xiaozhuang University,Nanjing ,China"
            },
            {
                "name": "ZHOU Feng",
                "org": "School of Biochemical and Environmental Engineering,Nanjing Xiaozhuang University,Nanjing ,China;Shandong Provincial Key Laboratory of Eco-Environmental Science for Yellow River Delta,Binzhou,Shandong ,China"
            },
            {
                "name": "ZHANG Bian-Jiang",
                "org": "School of Biochemical and Environmental Engineering,Nanjing Xiaozhuang University,Nanjing ,China"
            },
            {
                "name": "HUA Chun",
                "org": "School of Biochemical and Environmental Engineering,Nanjing Xiaozhuang University,Nanjing ,China"
            }
        ],
        "venue": "Plant Physiology Journal",
        "year": 2012
    },
    "Dkmg8xLD": {
        "id": "Dkmg8xLD",
        "title": "Characterization of Codon Usage of Arabidopsis Thaliana NHX Genes",
        "abstract": "CodonW software was applied to calculate the nucleotide composition,relative synonymous codon usage and other parameters of Arabidopsis thaliana NHX genes.The result indicted that Codon Adaptation Index was significantly and positively correlated with FOP and CBI,and the effective number of codons was significantly and negatively correlated with T3s contents.Arabidopsis thaliana NHX genes with RSCU>1 preferred codons usually end with A and T.",
        "keywords": [
            "Arabidopsis thaliana",
            "NHX genes",
            "codon"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "School of Biochemical and Environmental Engineering,Nanjing Xiaozhuang University,Nanjing ,Jiangsu"
            }
        ],
        "venue": "Journal of Nanjing Xiaozhuang University",
        "year": 2011
    },
    "7f6FGnti": {
        "id": "7f6FGnti",
        "title": "Analysis of HKT1 Gene in Glycophyte and Halophyte",
        "abstract": "The character of HKT1 gene encoding protein such as the constitution of amino acid,equipotential,domain,characteristic spots,secondary structure in three glycophyte and four halophyte were analyzed by a series of bioinformatics software.The results showed that there existed some difference between glycophyte and halophyte HKT1 gene in physicochemical properties,structure character and function,but the difference was not obvious.",
        "keywords": [
            "HKT1 gene",
            "halophyte",
            "glycophyte",
            "bioinformatics"
        ],
        "authors": [
            {
                "name": "YANG Ping",
                "org": "Nanjing Xiaozhuang University,Nanjing ,Jiangsu"
            }
        ],
        "venue": "Journal of Nanjing Xiaozhuang University",
        "year": 2010
    },
    "DqY1G5vW": {
        "id": "DqY1G5vW",
        "title": "The biological evolution of photosynthesis and its components",
        "abstract": "Photosynthesis is known as the most important chemical reaction on the earth.All forms of life on the earth need energy provided by photosynthesis to maintain and continue lives.Photosynthetic cofactors,chlorophylls,reaction centers,light harvesting complexes and ATP synthases are the main components of photosynthesis.The biological evolution processes of them are briefly reviewed in this paper.Photosynthesis is accomplished by photosynthetic organisms.The biological evolution processes of photosynthetic organisms and the three kinds of carbon fixation pathways in photosynthetic organisms are also discussed.",
        "keywords": [
            "photosynthesis",
            "quinine",
            "evolution",
            "chlorophyll"
        ],
        "authors": [
            {
                "name": "ZHOU Feng",
                "org": "School of Biochemical and Environmental Engineering,Nanjing Xiaozhuang University,Nanjing ,China"
            },
            {
                "name": "HUA Chun",
                "org": "School of Biochemical and Environmental Engineering,Nanjing Xiaozhuang University,Nanjing ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Biochemical and Environmental Engineering,Nanjing Xiaozhuang University,Nanjing ,China"
            }
        ],
        "venue": "Chemistry of Life",
        "year": 2013
    },
    "hwMtqmML": {
        "id": "hwMtqmML",
        "title": "Studies on the Karyotype and C-banding Pattern of Four Cultivated Barley",
        "abstract": "This paper is to study and analyze the Karyotype and C-banding pattern of chromosomes in four cultivars of cultivated barley.The result indicates that Giemsa C-band of four cultivars of cultivated barley is obviously distinct in quantity and intensity of bands.The different chromosomes show a diversity of C-banding patterns with different extent.",
        "keywords": [
            "C-banding",
            "cultivated barley",
            "polymorphism",
            "karyotype"
        ],
        "authors": [
            {
                "name": "CHEN Quan-zhan",
                "org": "Department of Life Science,Nanjing Xiaozhuang University,Nanjing ,Jiangsu"
            },
            {
                "name": "YANG Ping",
                "org": "Department of Life Science,Nanjing Xiaozhuang University,Nanjing ,Jiangsu"
            }
        ],
        "venue": "Journal of Nanjing Xiaozhuang University",
        "year": 2007
    },
    "xZANEZtB": {
        "id": "xZANEZtB",
        "title": "Bioinformatic Analysis of ThHKT1 Gene from Thellungiella Halophila",
        "abstract": "The character of ThHKT1 gene encoding protein such as the constitution of amino acids,isoelectric point,domain,characteristic spots and secondary structure in Thellungiella halophila were analyzed by a series of bioinformatics software.The results showed that this protein was stable,and the formula was C2631H4064N636O707S21.The secondary structure was primarily composed of random coil.The difference of ThHKT1 protein exists in Thellungiella halophila and three glycophytes(salt-sensitive plants).",
        "keywords": [
            "Glycophytes",
            "ThHKT1 gene",
            "glycophytes",
            "ThNHX1 gene",
            "Bioinformatics",
            "bioinformatics",
            "Thellungiella halophila"
        ],
        "authors": [
            {
                "name": "TANG Ning",
                "org": "Life Science Department,Nanjing Xiaozhuang College,Nanjing ,China"
            },
            {
                "name": "YANG Ping",
                "org": "Life Science Department,Nanjing Xiaozhuang College,Nanjing ,China"
            }
        ],
        "venue": "Pharmaceutical Biotechnology",
        "year": 2008
    },
    "midG8IdZ": {
        "id": "midG8IdZ",
        "title": "Characterization of Codon Usage of Arabidopsis thaliana POT Gene",
        "abstract": "CodonW software was applied to analyze the nucleotide composition,relative synonymous codon usage and other parameters of Arabidopsis thaliana POT gene.The results indicted that CAI was significantly positively correlated with C3s and CBI(P<0.05),and very significantly positively correlated with FOP(P<0.01);ENC was significantly positively correlated with C3s content(P<0.05),very significantly positively correlated with GC3s(P<0.01),and very significantly negatively correlated with T3s(P<0.01).Most codons with RSCU>1 of A.thaliana POT gene ended with A and T.",
        "keywords": [
            "Arabidopsis thaliana",
            "POT gene",
            "codon"
        ],
        "authors": [
            {
                "name": "WANG Fu-yuan",
                "org": "Higher Vocational and Technology School,China Pharmaceutical University,Nanjing ,China"
            },
            {
                "name": "TANG Ning",
                "org": "School of Biochemistry and Environmental Engineering,Nanjing Xiaozhuang College,Nanjing ,China"
            },
            {
                "name": "YANG Ping",
                "org": "School of Biochemistry and Environmental Engineering,Nanjing Xiaozhuang College,Nanjing ,China"
            }
        ],
        "venue": "Hubei Agricultural Sciences",
        "year": 2013
    },
    "A2cK6guI": {
        "id": "A2cK6guI",
        "title": "INFLUENCE OF COLUMNAR GRAINS ON THE COLD ROLLING TEXTURE EVOLUTION IN Fe--3%Si ELECTRICAL STEEL: INFLUENCE OF COLUMNAR GRAINS ON THE COLD ROLLING TEXTURE EVOLUTION IN Fe--3%Si ELECTRICAL STEEL",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weimin mao",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "ning zhang",
                "org": ""
            }
        ],
        "venue": "Acta Metallurgica Sinica",
        "year": 2013
    },
    "AdoMUS0Y": {
        "id": "AdoMUS0Y",
        "title": "Formation of a sharp {100} langle 011\rangle texture in Fe\u20133 %Si\u20131.7 %Mn\u20130.05 %C silicon steel sheets",
        "abstract": "Controlling the development of {100} texture in non-oriented electrical steels is important for improving the magnetic properties in this class of materials. In this paper, a {100}( langle 011rangle ) textured Fe\u20133 %Si\u20131.7 %Mn\u20130.05 %C silicon steel sheet has been processed by vacuum annealing and subsequent decarburization following the heavy cold rolling of a hot-rolled slab. After vacuum annealing, the surface layer transformed into thin \u03b1-ferrite with columnar grains, which grew inward during the subsequent decarburization annealing at the \u03b1 + \u03b3 duplex temperature. It has been demonstrated that cold rolling to high strains and increasing vacuum annealing temperature are the key factors for improving the {100}( langle 011rangle ) texture of the surface layer in a relatively short vacuum annealing time. Moreover, the formation of the {100}( langle 011rangle ) texture is attributed to the retention of the {100}( langle 011rangle ) texture formed during cold rolling and a growth advantage in the stage of vacuum annealing. The development of a strong {100}( langle 011rangle ) texture in the surface layer ferrite is strongly related to the growth advantage of grains with the {100}( langle 011rangle ) orientation, which consume the non-{100} grains during the vacuum annealing process.",
        "keywords": "",
        "authors": [
            {
                "name": "Jinhua Wang",
                "org": "School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, China"
            },
            {
                "name": "Ping Yang",
                "org": "School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, China"
            },
            {
                "name": "Louwen Zhang",
                "org": "School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, China"
            },
            {
                "name": "Weimin Mao",
                "org": "School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, China"
            }
        ],
        "venue": "Journal of Materials Science",
        "year": 2016
    },
    "aXA2dcfQ": {
        "id": "aXA2dcfQ",
        "title": "BEHAVIORS OF BRASS TEXTURE AND ITS INFLUENCE ON GOSS TEXTURE IN GRAIN ORIENTED ELECTRICAL STEELS",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "huijun song",
                "org": ""
            },
            {
                "name": "ping yang",
                "org": ""
            },
            {
                "name": "h qian",
                "org": ""
            },
            {
                "name": "mengqi yan",
                "org": ""
            },
            {
                "name": "weimin mao",
                "org": ""
            },
            {
                "name": "yuanyuan shao",
                "org": ""
            }
        ],
        "venue": "Acta Metallurgica Sinica",
        "year": 2012
    },
    "dWVxFlvf": {
        "id": "dWVxFlvf",
        "title": "Rapid texture measurement of annealed aluminum sheet based on X-ray diffraction",
        "abstract": "",
        "keywords": [
            "x ray diffraction"
        ],
        "authors": [
            {
                "name": "Weimin Mao",
                "org": "University of Science and Technology Beijing Department of Materials, State Key Laboratory of Advanced Metals and Materials 100083 Beijing China"
            },
            {
                "name": "Leng Chen",
                "org": "University of Science and Technology Beijing Department of Materials, State Key Laboratory of Advanced Metals and Materials 100083 Beijing China"
            },
            {
                "name": "Ping Yang",
                "org": "University of Science and Technology Beijing Department of Materials, State Key Laboratory of Advanced Metals and Materials 100083 Beijing China"
            },
            {
                "name": "Huiping Feng",
                "org": "University of Science and Technology Beijing Department of Materials, State Key Laboratory of Advanced Metals and Materials 100083 Beijing China"
            }
        ],
        "venue": "Chinese Science Bulletin",
        "year": 2004
    },
    "cmnCLKcs": {
        "id": "cmnCLKcs",
        "title": "Nitrogen behavior during nitriding treatment of electrical steel",
        "abstract": "With the help of field emission microscope and glow discharge optical spectrometry, the behavior of nitrogen which included the nitrogen contents in different thickness layers and types, shapes and distributions of nitride precipitates was investigated in specimens subjected to different nitriding and further isothermal annealing treatments. Meanwhile, the evolution of nitride particles during isothermal annealing was also observed. It reveals that nitrides after nitriding are mainly piled in surface layer. After the following process of isothermal annealing, nitrides in surface layer dissolve gradually and form precipitates again when they diffuse to subsurface. Thus, nitrides with small size can be well-distributed along the diffusion layer and evolve stably to secondary recrystallization.",
        "keywords": [
            "Electrical steel",
            "Inhibitors",
            "Low-temperature heating",
            "Nitriding treatment"
        ],
        "authors": [
            {
                "name": "Huijun Song",
                "org": "University of Science and Technology Beijing(University of Science and Technology Beijing),Beijing,China"
            },
            {
                "name": "Ping Yang",
                "org": "University of Science and Technology Beijing(University of Science and Technology Beijing),Beijing,China"
            },
            {
                "name": "Weimin Mao",
                "org": "University of Science and Technology Beijing(University of Science and Technology Beijing),Beijing,China"
            }
        ],
        "venue": "Jinshu Rechuli/Heat Treatment of Metals",
        "year": 2012
    },
    "vv0ppDHj": {
        "id": "vv0ppDHj",
        "title": "Phenomena of \u03a33 and Orientation Gradients in an ElectricalSteel Applied\u03b1\u2192\u03b3\u2192\u03b1 Transformation",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Louwen Zhang",
                "org": ""
            },
            {
                "name": "Ping Yang",
                "org": ""
            },
            {
                "name": "Weimin Mao",
                "org": ""
            }
        ],
        "venue": "Acta Metallurgica Sinica",
        "year": 2016
    },
    "kgo3sKNJ": {
        "id": "kgo3sKNJ",
        "title": "Influence of structure transition on plastic behaviors of iron based ordered alloys",
        "abstract": "The influence of ordered structure on the dislocation configuration,structure of anti-phase domain boundary,partial dislocation slips,etc.are analyzed in the background of promoting the plasticity of iron based ordered solid solutions with second-order phase transformation.The principles of deformation softening and annealing hardening in ordered solid solutions are discussed because of deformation induced structure disordering.It is concluded that the independent slip ability of the partial dislocations and the corresponding low temperature plasticity of ordered solid solutions could be promoted obviously by proper alloying effects,which reduces the anti-phase domain boundary energy,or by maintaining the disordering state into the low temperature range.The similar principles could be also used to modify the low temperature plasticity of other metal based ordered solid solutions.",
        "keywords": [
            "structure transition",
            "ordered alloys",
            "solid solutions",
            "dislocation structure",
            "plasticity"
        ],
        "authors": [
            {
                "name": "weimin mao",
                "org": "university of science and technology beijing"
            },
            {
                "name": "ping yang",
                "org": "university of science and technology beijing"
            }
        ],
        "venue": "\u4e2d\u56fd\u79d1\u5b66:\u6280\u672f\u79d1\u5b66(\u82f1\u6587\u7248)",
        "year": 2012
    },
    "zczPKf34": {
        "id": "zczPKf34",
        "title": "Application of Various Methods of Transurethral Plasmakinetic Resection of Prostate",
        "abstract": "Objective To explore the effects and methods of transurethral plasmakinetic resection of prostate(PKRP).Methods A total of 156 patients with prostatic hyperplasia were treated with various methods of transurethral PKRP from July 2008 to December 2009.Patient's age ranged from 59 to 87 years,74 years on average.The disease duration was 20 days to 18 years.Method one:anterograde resection in 38 patients;method two:partition retrograde enucleation in 76 patients;method three:completely retrograde enucleation in 42 patients.Results All of the swgeries were successful.The mean duration of the operation was 90 minutes.The collected prostatic specimens were 12-87 g,35 g on average.The mean catheter remaining dwation was 5.5 days.The mean postoperative hospital stay was 6.5 days.Conclusions PKRP is safe and effective.It is effective with various methods of transurethral plasmakinetic resection of prostate.",
        "keywords": [
            "Benign prostate hyperplasia",
            "Transurethral resection of prostate",
            "Plasmakinetic resection"
        ],
        "authors": [
            {
                "name": "HE Bing-xun",
                "org": ".Department of Urology,The Second Hospital of Liangshan,Xichang,Sichuan,,P.R.China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": ".Department of Urology,The Second Hospital of Liangshan,Xichang,Sichuan,,P.R.China"
            }
        ],
        "venue": "West China Medical Journal",
        "year": 2011
    },
    "z1nSOWZw": {
        "id": "z1nSOWZw",
        "title": "Transurethral Enucleation of Prostate for Benign Prostatic Hyperplasia",
        "abstract": "Objective To evaluate the therapeutic effect of transurethral enucleation of prostate on benign prostatic hyperplasisa.Methods From December 2007 to July 2010,201 patients with benign prostatic hyperplasia underwent transurethral enucleation.According to the size and shape of the gland,different enucleation ways were used to improve the surgical success rate.Results All of the enucleations were successful.The average weight of the resected prostate was 38 grams,the mean operation duration was 100 minutes,the average days of indwelling catheter was 5-7 days,and the average hospital staying was 5.5 days.Conclusion Transurethral enucleation of prostate for benign prostatic hyperplasia is effective.",
        "keywords": [
            "Benign prostatic hyperplasia",
            "Transurethral enucleation"
        ],
        "authors": [
            {
                "name": "ZHU Wei-guo",
                "org": ".The First Department of Surgery,the Second People's Hospital of Liangshan,Xichang,Sichuan ,P.R.China"
            },
            {
                "name": "HE Bing-xun",
                "org": ".The First Department of Surgery,the Second People's Hospital of Liangshan,Xichang,Sichuan ,P.R.China"
            },
            {
                "name": "ZHU Zhi-hu",
                "org": ".The First Department of Surgery,the Second People's Hospital of Liangshan,Xichang,Sichuan ,P.R.China"
            },
            {
                "name": "XUE Bin",
                "org": ".The First Department of Surgery,the Second People's Hospital of Liangshan,Xichang,Sichuan ,P.R.China"
            }
        ],
        "venue": "West China Medical Journal",
        "year": 2011
    },
    "8ORTumD7": {
        "id": "8ORTumD7",
        "title": "An research on the expression of IL-8 in PMVEC and its mechanism through the Nuclear Factor-Kappa B",
        "abstract": "Objective To study IL-8 expression of pulmonary microvascular endothelial cells(PMVEC) directly induced by LPS and its mechanism through the Nuclear Factor-Kappa B.Methods When PMVEC is directly excited by 100ng/ml LPS at 0h,(0.5)h,1h,2h,4h,6h,8h or 1ng/ml,10ng/ml,100ng/mlLPS at 1h or 6h,the expressions of IL-8mRNA in PMVEC and its protein secretion in the supernatant of culture medium were examined by the methods of ISH,ELISA respectively and the activation of NF-\u03baB was detected by EMSA.And those were then to be compared with which was inhibited by PDTC.Results LPS could directly act on the PMVEC to promote the IL-8 expression,including promoting the expression of IL-8mRNA and secretion of IL-8 protein,and the mRNA expressions increased before the protein secreted in terms of time.The LPS excitement could also significantly promote the activation of NF-\u03baB,which peaked at 1h and then went down.PDTC could significantly decrease the expression of IL-8 and the activation of NF\u03baB.Conclusion The directly-induction of LPS could exactly promote the activation of NF-\u03baB,then cause to the expression and secretion of IL-8.So as to provide the required physical condition for the PMN migration.It could be an important role in inflammatory response induced by LPS.",
        "keywords": [
            "PMVEC",
            "LPS",
            "PMN",
            "NF-kB",
            "IL-8"
        ],
        "authors": [
            {
                "name": "Zhu Weiguo",
                "org": ",et al.The Second People's Hospital of Liangshan,Xichang Sichuan ,China"
            },
            {
                "name": "Jin Yanhua",
                "org": ",et al.The Second People's Hospital of Liangshan,Xichang Sichuan ,China"
            },
            {
                "name": "Bai Xiaohong",
                "org": ",et al.The Second People's Hospital of Liangshan,Xichang Sichuan ,China"
            }
        ],
        "venue": "Sichuan Medical Journal",
        "year": 2005
    },
    "G5fwUBVA": {
        "id": "G5fwUBVA",
        "title": "Local Infiltration Anesthesia for Circumcision Cerclage Report 2452 Cases",
        "abstract": "Objective: To investigate the clinical application and effect of circumcision cerclage for patients with phimosis.Methods: 2452 cases of phimosis were treated with circumcision cerclage.Results: The mean operative time was 7.5 minutes,the average decyclizing time on the follow-up of 1824 cases was 14.5 days.Excised edge skin was smooth,soft,clean and naturally turn up.Conclusion: The circumcision cerclage was safe,efficient,effective and suitable for all age patients with phimosis.Local infiltration anesthesia was suitable for this surgery.",
        "keywords": [
            "anesthesia",
            "circumcision cerclage",
            "phimosis"
        ],
        "authors": [
            {
                "name": "HE Bing-xun",
                "org": ",et al.1.Department of Urology,the Second People's Hospital of Liangshan,Liangshan Sichuan ,China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": ",et al.1.Department of Urology,the Second People's Hospital of Liangshan,Liangshan Sichuan ,China"
            },
            {
                "name": "ZHANG Xiao-Guo",
                "org": ",et al.1.Department of Urology,the Second People's Hospital of Liangshan,Liangshan Sichuan ,China"
            },
            {
                "name": "YE Yi",
                "org": ",et al.1.Department of Urology,the Second People's Hospital of Liangshan,Liangshan Sichuan ,China"
            }
        ],
        "venue": "West China Medical Journal",
        "year": 2009
    },
    "8oO5FggU": {
        "id": "8oO5FggU",
        "title": "Pneumatic Lithotripsy Combined with TURP in the Treatment of Bladder Calculi with Benign Prostate Hyperplasia",
        "abstract": "Objective:To study the effective treatment for patients with benign prostate hyperplasia (BPH) complicated with bladder calculi. Methods: Twenty-six cases of BPH complicated with bladder calculi were treated with pneumatic lithotripsy and transurethral resection of prostate (TURP) at the same time. Results: Twenty-four cases were successfully treated in one operation. One was treated with one-stage pneumatic lithotripsy and two-stage TURP. One was transferred to operation. Conclusion: Pneumatic lithotripsy combined with TURP seems to be a safe and efficient method for patients with BPH and bladder calculi.",
        "keywords": [
            "bladder calculi",
            "transurethral resection of prostate",
            "pneumatic lithotripsy",
            "benign prostate hyperplasia"
        ],
        "authors": [
            {
                "name": "HE Bing-xun",
                "org": ". Department of Urology, the Second People\u2019s Hospital of Liangshan, Liangshan Sichuan , China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": ". Department of Urology, the Second People\u2019s Hospital of Liangshan, Liangshan Sichuan , China"
            }
        ],
        "venue": "West China Medical Journal",
        "year": 2009
    },
    "pPFdCePN": {
        "id": "pPFdCePN",
        "title": "Minimally Invasive Percutaneous Nephrolithotomy Report of 41 Cases",
        "abstract": "Objective:To investigate the minimally invasive percutaneous nephrolithotomy(MPCNL)the efficacy of the treatment of kidney stones.Methods:MPCNL treatment of 41 cases of patients with kidney stones,of which 30 cases of kidney stones(stone diameter> 2.0 cm),upper 11 cases of stones(stone diameter of 1.0-2.0 cm);single stone of 37 cases,4 cases of bilateral stones.Results:Fourty-one cases were treated success fully.Operation time 45-120 min,an average of 52.7 min,no case to open surgery.This group of cases of kidney stone removal of a single 26 cases(86.7%),4 cases of residual stones line the second phase operation taking the net;upper single stone-free rate of 100%.Conclusion:MPCNL is an effective method of treatment of kidney stones,with less trauma and stone high rate of speed the resumption of the advantages.",
        "keywords": [
            "percutaneous nephrolithotomy",
            "upper stone",
            "treatment",
            "kidney stones"
        ],
        "authors": [
            {
                "name": "ZHU Wei-guo",
                "org": ".Department of Urology,the Second People's Hospital of Liangshan,Liangshan Sichuan ,China"
            },
            {
                "name": "HE Bing-xun",
                "org": ".Department of Urology,the Second People's Hospital of Liangshan,Liangshan Sichuan ,China"
            },
            {
                "name": "XIAO Xiao-wei",
                "org": ".Department of Urology,the Second People's Hospital of Liangshan,Liangshan Sichuan ,China"
            }
        ],
        "venue": "West China Medical Journal",
        "year": 2009
    },
    "S7UqzPW1": {
        "id": "S7UqzPW1",
        "title": "Efficacy Analysis of Minimally Invasive Percutaneous Nephrolithotomy in Treatment of Complicated Uretera Calculi",
        "abstract": "Objective To evaluate the clinical effect of minimally invasive percutaneous nephrolithotomy (mPCNL) in treatment of complex upper ureteral calculi. Methods The clinical data of 180 patients with complex upper ureteral calculi treated by Mpcnl were retrospectively analyzed. Results Operation time was 80 to 120 minutes, with an average of (90 \u00b1 10) minutes. One-time surgical success rate was 100%, and one-time stone-free rate was 99%, without additional surgical interventione and no serious complications. Conclusions Ninimally invasive percutaneous nephrolithotomy has the advantages of less trauma, faster recovery, higher stones depletion rate, safety and effectiveness, which can be used as first option in treatment of complex upper ureteral calculi.",
        "keywords": [
            "Minimally invasive percutaneous nephrolithotomy",
            "Complex upper ureteral calculi"
        ],
        "authors": [
            {
                "name": "KANG Houbin",
                "org": "Deparyment of Urology, the Second People's Hospital of Liangshan, Xichang , China"
            },
            {
                "name": "ZHU Weiguo",
                "org": "Deparyment of Urology, the Second People's Hospital of Liangshan, Xichang , China"
            },
            {
                "name": "HE Bingxun",
                "org": "Deparyment of Urology, the Second People's Hospital of Liangshan, Xichang , China"
            },
            {
                "name": "ZHU Zh",
                "org": "Deparyment of Urology, the Second People's Hospital of Liangshan, Xichang , China"
            },
            {
                "name": "XUE Bin",
                "org": "Deparyment of Urology, the Second People's Hospital of Liangshan, Xichang , China"
            },
            {
                "name": "YUAN Yi",
                "org": "Deparyment of Urology, the Second People's Hospital of Liangshan, Xichang , China"
            },
            {
                "name": "AI Hangyu",
                "org": "Deparyment of Urology, the Second People's Hospital of Liangshan, Xichang , China"
            }
        ],
        "venue": "Clinical Medical & Engineering",
        "year": 2011
    },
    "WQj45Wzl": {
        "id": "WQj45Wzl",
        "title": "Synthesis and Spectral Studies of 4-Bromo-N,N-Bis(4-tert-butylphenyl) Phenylamine",
        "abstract": "4-bromo-N,N-Bis(4-tert-butylphenyl) phenylamine,which used as an intermediate of electrophosphorescent material,was synthesized using 4-bromoaniline and 4-tert-butylbenzoic acid as the initial materials through Hofmann degradation,diazotization and Ullmann reaction with a yield of 43.5%.The chemical structure was characterized with ~(1)H NNR and MS.The results showed that this compound had intense UV absorption and fluorescent properties.A maximum UV absorption peak at 306 nm and a fluorescent emission peak at 543 nm were exhibited in CHCl_(3).Compared to the solution fluorescent emission,the blue-shifted fluorescent emission peak at 458 nm was observed in its film.",
        "keywords": [
            "N-bis(4-tert-butylphenyl)-4-bromo-phenylamine",
            "N",
            "hole-transporting materials",
            "synthesis",
            "electrophosphorescence"
        ],
        "authors": [
            {
                "name": "Xing Kongqiang",
                "org": "College of Chemistry,Xiangtan University,Xiangtan  China;Department of Chemistry,Qiongzhou University,Wuzhishan  China"
            },
            {
                "name": "Liu Yu",
                "org": "College of Chemistry,Xiangtan University,Xiangtan  China;Department of Chemistry,Qiongzhou University,Wuzhishan  China"
            },
            {
                "name": "Zhu Meixiang",
                "org": "College of Chemistry,Xiangtan University,Xiangtan  China"
            },
            {
                "name": "Su Guojun",
                "org": "College of Chemistry,Xiangtan University,Xiangtan  China"
            },
            {
                "name": "Zhu Weiguo",
                "org": "College of Chemistry,Xiangtan University,Xiangtan  China"
            }
        ],
        "venue": "Natural Science Journal of Xiangtan University",
        "year": 2006
    },
    "ZV1LO1pC": {
        "id": "ZV1LO1pC",
        "title": "Synthesis and optophysical properties of blue-emitting iridium (III) complex bearing oxadiazole-based picolinic acid derivative",
        "abstract": "An iridium (III) bis[(4,6-difluorophenyl)pyridinato-N, C2][6-(6\u2032-(4\u2033-(5\u2034-phenyl-1\u2034, 3\u2034, 4\u2034-oxadiazole- 2\u2034-yl) phenoxy) hexyloxy picolinate) was synthesized and characterized by 1H NMR and elementary analysis in order to study the effect of ancillary ligand of the oxadiazole-based picolinic acid derivative\n on optophysical properties of its iridium complex, and further to obtain an iridium complex with highly-efficient blue emission.\n The thermal stability, UV absorption and photoluminescent properties of this iridium complex were investigated. Compared with\n iridium (III) bis[(4,6-difluorophenyl)pyridinato-N, C2](picolinate) reported as a highly-efficient blue electroluminescent material, this iridium complex bearing an oxadiazole-based\n picolinic acid derivative presents higher thermal stability, more intense UV absorption at 291 nm and similar photoluminescent\n spectrum peaked at 469 nm. This indicates that tuning ancillary ligand of picolinic acid with an oxadiazole unit can improve\n the optophysical properties of its iridium complex.",
        "keywords": [
            "3",
            "1",
            "iridium complex",
            "4-oxadiazole",
            "synthesis",
            "optophysical properties",
            "spectrum",
            "electroluminescence",
            "thermal stability"
        ],
        "authors": [
            {
                "name": "Zhong-lin Wen",
                "org": "Xiangtan University College of Chemistry Xiangtan 411105 China"
            },
            {
                "name": "Zheng-yong Hu",
                "org": "Xiangtan University College of Chemistry Xiangtan 411105 China"
            },
            {
                "name": "Yu Liu",
                "org": "Xiangtan University College of Chemistry Xiangtan 411105 China"
            },
            {
                "name": "Fang-liang Xiao",
                "org": "Xiangtan University College of Chemistry Xiangtan 411105 China"
            },
            {
                "name": "Xiao-yun Ma",
                "org": "Xiangtan University College of Chemistry Xiangtan 411105 China"
            },
            {
                "name": "Mei-xiang Zhu",
                "org": "Xiangtan University College of Chemistry Xiangtan 411105 China"
            },
            {
                "name": "Wei-guo Zhu",
                "org": "Xiangtan University College of Chemistry Xiangtan 411105 China"
            }
        ],
        "venue": "Journal of Central South University of Technology",
        "year": 2009
    },
    "kohe4GcY": {
        "id": "kohe4GcY",
        "title": "Star-shaped trinuclear cyclometalated platinum(II) complexes as single-component emitters in white-emitting PLEDs.",
        "abstract": "Two star-shaped phosphorescent small molecules, Ph-3FPt(pic) and 4Ph-3FPt(pic), are single-component emitters in polymer white-light-emitting diodes (WPLEDs) that are comprised of three blue-light-emitting phosphorescent chromophores of FPt(pic) and are attached to benzene-1,3,5-trioxy- and 1,3,5-tri(4-oxyphenyl)benzene cores through a hexyloxy chain, respectively. Compared to their corresponding mono- or dinuclear platinum complexes, this class of star-shaped homotrinuclear cyclometalated platinum(II) complexes exhibited controllable excimer emission. Stable white/near-white emission was obtained in single-emissive-layer PLEDs by using the Ph-3FPt(pic) or 4Ph-3FPt(pic) as a single dopant and a blend of poly(vinylcarbazole) and 2-(4-biphenyl)-5-(4-tert-butyl-phenyl)-1,3,4-oxadiazole as a host matrix at dopant concentrations of 1-4 wt.%. Our results provide an efficient way to control excimer formation and to obtain a single-component emitter for use in WPLEDs.",
        "keywords": [],
        "authors": [
            {
                "name": "Danyan Shi",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China."
            },
            {
                "name": "Yafei Wang",
                "org": ""
            },
            {
                "name": "Yu Liu",
                "org": ""
            },
            {
                "name": "Zhiyong Zhang",
                "org": ""
            },
            {
                "name": "Jian Luo",
                "org": ""
            },
            {
                "name": "Juan He",
                "org": ""
            },
            {
                "name": "Qing Chen",
                "org": ""
            },
            {
                "name": "Gangtie Lei",
                "org": ""
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            }
        ],
        "venue": "Chemistry, an Asian journal",
        "year": 2012
    },
    "qrStRP8J": {
        "id": "qrStRP8J",
        "title": "Synthesis,Characterization and DNA-Binding Studies of [Ru(bpy)_2(PyIP)]~(2+) and [Ru(dmb)_2(PyIP)]~(2+)",
        "abstract": "Two novel polypyridyl {PyIP = 2-(pyren-1-yl)-1H-imidazo phenanthroline,bpy = 2,2\u2032-bipyridine,dmb = 4,4\u2032-dimethyl-2,2\u2032-bipyridine} ruthenium(II) complexes [Ru(bpy)2(PyIP)]2+(1) and [Ru(dmb)2(PyIP)]2+(2) have been synthesized and characterized by elemental analysis,ES-MS and 1H NMR spectroscopy.The DNA-binding of these complexes were investigated by spectroscopic methods and viscosity measurements.The experimental results indicate that both complexes 1 and 2 bind to calf thymus DNA in classical intercalation mode,and however,complex 1 intercalated more strongly than complex 2,due to the different ancillary ligands.",
        "keywords": [
            "DNA-binding",
            "Ruthenium(II) complexes"
        ],
        "authors": [
            {
                "name": "TAN Li-feng",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ;Key Lab of Environment-friendly Chemistry and Application in Ministry of Education,Xiangtan University,Xiangtan  China"
            },
            {
                "name": "XIAO Yue",
                "org": "College of Chemistry,Xiangtan University,Xiangtan "
            },
            {
                "name": "ZHU Wei-guo",
                "org": "College of Chemistry,Xiangtan University,Xiangtan "
            },
            {
                "name": "ZHOU Yuan-qing",
                "org": "College of Chemistry,Xiangtan University,Xiangtan "
            },
            {
                "name": "ZHANG Sheng",
                "org": "College of Chemistry,Xiangtan University,Xiangtan "
            }
        ],
        "venue": "Natural Science Journal of Xiangtan University",
        "year": 2008
    },
    "Y9TfyoX9": {
        "id": "Y9TfyoX9",
        "title": "Structure identification and anti-botulinum effect of hydrolytic and hydrogenated reductive products of toosendanin",
        "abstract": "Objective To identify the structure of products of hydrolysis and hydrogenation reduction of toosendanin and examine their anti-botulinum neurotoxin(anti-BoNT) activities.Methods Toosendanin was hydrolyzed by ammonia and reduced by lithium aluminium tetrahydride.The products were purified by HPLC and characterized by FAB-MS and 1H-NMR.Their detoxification activities to botulinum A(BoNT/A) were determined after the intraperitoneal administration of 2LD50 BoNT/A into mice.The survival rate was recorded for 4 days.Results and Conclusion Two mono-deacetylated products and one epoxy opening product were obtained and characterized.The toxicity and detoxification activities to botulinum A of these products decreased significantly.This work will contribute to the toosendanin pharmacokinetics in vivo and application.",
        "keywords": [
            "detoxification",
            "botulinum neurotoxins A",
            "hydrogenation-reduction",
            "hydrolysis",
            "toosendanin"
        ],
        "authors": [
            {
                "name": "LI Hai-tao",
                "org": "College of Chemistry,Xiangtan University,Xiangtan,Hunan ,China;Institute of Biotechnology,Academy of Military Medical Sciences,Beijing ,China"
            },
            {
                "name": "DONG Ming-xin",
                "org": "Institute of Biotechnology,Academy of Military Medical Sciences,Beijing ,China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": "College of Chemistry,Xiangtan University,Xiangtan,Hunan ,China"
            },
            {
                "name": "YU Yun-zhou",
                "org": "Institute of Biotechnology,Academy of Military Medical Sciences,Beijing ,China"
            },
            {
                "name": "SHU Guo-xin",
                "org": "Institute of Microbiology and Epidemiology,Academy of Military Medical Sciences,Beijing ,China"
            },
            {
                "name": "DAI Qiu-yun",
                "org": "Institute of Biotechnology,Academy of Military Medical Sciences,Beijing ,China"
            }
        ],
        "venue": "Military Medical Sciences",
        "year": 2012
    },
    "rh4rtt6d": {
        "id": "rh4rtt6d",
        "title": "Synthesis of 2-(2,4-Difluoro)Phenyl-5-Alkyloxy Methyl Pyridine Derivatives",
        "abstract": "A class of 2-(2,4-difluoro)phenyl-5-alkyloxy methyl pyridine derivatives was synthesized by formylation reaction,reduction reaction,ether-forming reaction and Suzuki-Miyaura corss-coupling reaction,respectively.The influence of molecular structure on the ether-forming reaction and Suzuki-Miyaura corss-coupling reaction was also investigated.The yileds of formylation reaction,reduction reaction,ether-forming reaction and Suzuki-Miyaura corss-coupling reaction were 49.8%,96.0%,90.3% and 96.9%,respectively.",
        "keywords": [
            "6-bromo-3-pyridinyl methanol",
            "4-difluoro)phenyl-5-alkyloxy methyl pyridine",
            "synthesis",
            "2-(2"
        ],
        "authors": [
            {
                "name": "ZHU Wei-guo",
                "org": "Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education,College of Chemistry,Xiangtan University,Xiangtan  China"
            },
            {
                "name": "ZHU Ke-ming",
                "org": "Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education,College of Chemistry,Xiangtan University,Xiangtan  China"
            },
            {
                "name": "LIANG Ai-hui",
                "org": "Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education,College of Chemistry,Xiangtan University,Xiangtan  China"
            },
            {
                "name": "LUO Jian",
                "org": "Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education,College of Chemistry,Xiangtan University,Xiangtan  China"
            },
            {
                "name": "LIU Yu",
                "org": "Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education,College of Chemistry,Xiangtan University,Xiangtan  China"
            },
            {
                "name": "MA Xiao-yun",
                "org": "Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education,College of Chemistry,Xiangtan University,Xiangtan  China"
            },
            {
                "name": "ZHU Mei-xiang",
                "org": "Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education,College of Chemistry,Xiangtan University,Xiangtan  China"
            }
        ],
        "venue": "Natural Science Journal of Xiangtan University",
        "year": 2009
    },
    "geuMfAII": {
        "id": "geuMfAII",
        "title": "Synthesis and optoelectronic properties of flourene-carbazole organic phosphorescent polymers pending cyclomatlated iridium complex moiety",
        "abstract": "A novel flourene-alt-karbazole organic phosphorescenct polymers (PFCzIrpiq) containing a pendent phosphor chromophore of the (Piq)2Ir(Pic) were synthesized via Suzuki coupling reaction. Their molecular mass was measured by gel permeation chromatograph, chemical structure was characterized by 1H NMR, and the photophysical property, thermal stability and electrochemical property of these polymers were investigated by UV absorption spectra, fluorescence spectra, thermogravimetric analysis and cyclic voltammetry. Using the polymers as emitting layer, the devices were made with a configuration of ITO/PEDOT: PSS (50 nm)/PFCzIrpiq (45 nm)/LiF(0.5 nm)/Al(150 nm), and their electroluminescent properties were measured. The results show that the molar percentage of (Piq)2Ir(Pic) in these polymers has great influence on light-emitting color of these polymers. When the molar percentage was 1%, the device exhibited blue emission with a CIE coordinate of (0.22, 0.22); when the percentage was increased to 5%, the device emitted saturated red light with a CIE coordinate(0.65, 0.35). Furthermore, with the increasing of molar percentage of (Piq)2Ir(Pic), the current density decreased and the maximum brightness increased gradually. When the molar percentage was 5%, the maximum brightness of 48 cd/m2 was achieved. \u00a9 Copyright.",
        "keywords": [
            "Optoelectronic properties",
            "Organic phosphorescent polymers",
            "Organic polymer materials",
            "Polymeric electroluminescent devices",
            "Synthesis"
        ],
        "authors": [
            {
                "name": "Jiyong Deng",
                "org": "Hunan Institute of Engineering(Hunan Institute of Engineering),Xiangtan,China"
            },
            {
                "name": "Yu Liu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Hua Tan",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Xianwei Huang",
                "org": "Hunan Institute of Engineering(Hunan Institute of Engineering),Xiangtan,China"
            },
            {
                "name": "Saijin Huang",
                "org": "Hunan Institute of Engineering(Hunan Institute of Engineering),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "Cailiao Yanjiu Xuebao/Chinese Journal of Materials Research",
        "year": 2013
    },
    "z7jLgAzn": {
        "id": "z7jLgAzn",
        "title": "Synthesis of Picolinic Acid Derivatives Containing Triarylamine Units",
        "abstract": "A novel series of the picolinic acid derivatives containing triarylamine units were synthesized through diazo-reaction,Ullmann reaction and Suzuki coupling reaction.Their molecular structures were characterized by 1H NMR and element analysis.The influence of the phase-transfer catalysis on the Ullmann reaction and the effect of molecular structures of bromo-triarylamines on Suzuki coupling reaction were investigated.The results show that Ullmann reaction and Suzuki coupling reaction exhibited a good yield of 48.9% and 25.8%,respectively.The approach is available to synthesize picolinic acids derivatives.",
        "keywords": [
            "triarylamine",
            "picolinic acid",
            "synthesis",
            "electrophosphorescence"
        ],
        "authors": [
            {
                "name": "ZHU Wei-guo",
                "org": "College of Chemistry,Xiangtan University,Xiangtan  China"
            },
            {
                "name": "HUANG Feng-liang",
                "org": "College of Chemistry,Xiangtan University,Xiangtan  China"
            },
            {
                "name": "HU Zheng-yong",
                "org": "College of Chemistry,Xiangtan University,Xiangtan  China"
            },
            {
                "name": "WEN Zhong-lin",
                "org": "College of Chemistry,Xiangtan University,Xiangtan  China"
            },
            {
                "name": "YANG Yu-ping",
                "org": "College of Chemistry,Xiangtan University,Xiangtan  China"
            }
        ],
        "venue": "Natural Science Journal of Xiangtan University",
        "year": 2007
    },
    "cjA3UKOo": {
        "id": "cjA3UKOo",
        "title": "Synthesis of 2-aryl-5-(4-bromophenyl)-1,3,4-oxadiazole Derivatives and Studies on Their Spectral Properties",
        "abstract": "A class of 2-aryl-5-(4-bromophenyl)-1,3,4-oxadiazole derivatives was prepared by dehydration of diarylhydrazide.The influence of reaction condition on synthesis was investigated.A yield of 78.9% was obtained in dehydration reaction.The molecular structures of these derivatives were characterized by IR and ~(1)HNMR respectively.The UV absorption and photoluminescent properties were also studied.The results show that all these 1,3,4-oxadiazole derivatives have a maximum UV absorptions wavelength in 280\uff5e301 nm and a peak photoluminescent wavelength in 350\uff5e370 nm.The aryl groups have an effect on the UV absorption and photoluminescent properties of these 1,3,4-oxadiazole derivatives.",
        "keywords": [
            "3",
            "1",
            "electrophosphorescent materials",
            "4-oxadiazole",
            "photoluminescence"
        ],
        "authors": [
            {
                "name": "LIU Yu",
                "org": "College of Chemistry,Xiangtan University,Xiangtan  China;Department of Chemistry,Qiongzhou University,Wuzhishan  China"
            },
            {
                "name": "SU Guojun",
                "org": "College of Chemistry,Xiangtan University,Xiangtan  China"
            },
            {
                "name": "XING Kongqiang",
                "org": "College of Chemistry,Xiangtan University,Xiangtan  China;Department of Chemistry,Qiongzhou University,Wuzhishan  China"
            },
            {
                "name": "GAN Quan",
                "org": "College of Chemistry,Xiangtan University,Xiangtan  China"
            },
            {
                "name": "YANG Yuping",
                "org": "College of Chemistry,Xiangtan University,Xiangtan  China"
            },
            {
                "name": "WANG Xiayu",
                "org": "College of Chemistry,Xiangtan University,Xiangtan  China"
            },
            {
                "name": "ZHU Weiguo",
                "org": "College of Chemistry,Xiangtan University,Xiangtan  China"
            }
        ],
        "venue": "Natural Science Journal of Xiangtan University",
        "year": 2006
    },
    "5SUucvCe": {
        "id": "5SUucvCe",
        "title": "Iridium(\u2162) complexes with 5-substitute-8-quinolinolates and 2-phenylpyridine as ligands:Synthesis,characterization and photoluminescent as well as electroluminescent properties",
        "abstract": "The synthesis,structures and photophysics of a series of heteroleptic iridium(\u2162) complexes with 5-substitute-8-quinolinolates and 2-phenylpyridine as the cyclometalating ligands are reported.The complexes have the general structure (C^N)2IrQ,where C^N represents 2-phenylpyridine and Q is derivatives of 8-hydroxyquinoline.The crystal structure of the complex (ppy)2IrQPhOMe (7b) has been determined by X-ray crystallography.Assessment of the thermal stabilities of the complexes reveals greatly differences depending on the substituents on the quinolinolato ligand.At room temperature,the complexes with 5-phenyl-quinolinolato ligand have red phosphorescent emission with two structured emission peaks,which are almost equal intensity at 666 and 687 nm.It is found that the emission characteristics are dominated by the 5-phenyl-quinolinolato ligand,whereas substitute groups on phenyl have less impact on the emission characteristics.Furthermore,the complex with 5-amido-8hydroxyquinoline as ligand,complex 8,shows unstructured emission at 550 nm,which is similar to (ppy)2Ir(acac) suggesting 2-phenylpyridine governed emission in this case.The polymer phosphorescent organic light-emitting device (OLED) was fabricated by doping complex 7b in PFO + 30 wt% PBD,and gives red EL spectra with CIE coordinates of (0.61,0.33) at 14 V and maximum luminance intensity of 350 cd/m2 at 18V.",
        "keywords": [
            "iridium(\u2162) complexes",
            "5-substituted-8-hydroxyquinoline",
            "polymer phosphorescent organic light-emitting devices (POLEDs)",
            "crystal structure",
            "red luminescence"
        ],
        "authors": [
            {
                "name": "CHEN YanFang",
                "org": " 1 College of Chemistry and Materials Science,Sichuan Normal University,Chengdu ,China 2 Key Laboratory of Environment-Friendly Chemistry and Application in Ministry of Education"
            },
            {
                "name": "LUO KaiJun",
                "org": " 1 College of Chemistry and Materials Science,Sichuan Normal University,Chengdu ,China 2 Key Laboratory of Environment-Friendly Chemistry and Application in Ministry of Education"
            },
            {
                "name": "SU YiWei",
                "org": " 1 College of Chemistry and Materials Science,Sichuan Normal University,Chengdu ,China 2 Key Laboratory of Environment-Friendly Chemistry and Application in Ministry of Education"
            },
            {
                "name": "DENG XianPing",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,China"
            },
            {
                "name": "ZHU WeiGuo",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,China"
            },
            {
                "name": "JIA Juan",
                "org": " 1 College of Chemistry and Materials Science,Sichuan Normal University,Chengdu ,China 2 Key Laboratory of Environment-Friendly Chemistry and Application in Ministry of Education"
            },
            {
                "name": "LI MaoWei",
                "org": " 1 College of Chemistry and Materials Science,Sichuan Normal University,Chengdu ,China 2 Key Laboratory of Environment-Friendly Chemistry and Application in Ministry of Education"
            },
            {
                "name": "ZHAO BaiJing",
                "org": " 1 College of Chemistry and Materials Science,Sichuan Normal University,Chengdu ,China 2 Key Laboratory of Environment-Friendly Chemistry and Application in Ministry of Education"
            }
        ],
        "venue": "Scientia Sinica(Chimica)",
        "year": 2013
    },
    "ehmy4OO7": {
        "id": "ehmy4OO7",
        "title": "Design,synthesis and biological activity of bicyclic piperidine-based HIV-1 inhibitors",
        "abstract": "CCR5 is a major co-receptor for HIV-1 entry into human cells and is also a good target for anti-HIV-1 drug design.Based on the chemical structure of Vicriviroc,a CCR5 antagonist,a series of new compounds were designed by changing its piperazine loop and other group substitutions.In the present study,15 bicyclic piperidine-based compounds were synthesized using a convergent synthetic route,and the structures of the target compounds were confirmed by MS and 1H-NMR.The synthetic routes were as follows:N-Boc-piperidine-4-carboxylic acid,N-Boc-pyrro-3-carboxylic acid and N-Boc-ethylenediamine were coupled with the amine derivatives to give the corresponding compounds 1a-1d,2a-2c,3a-3c,4-piperidinone hydrochloride reacted with 2,6-dimethylbenzoyl chloride,2,6-dichlorobenzoyl chloride and 2,4,6-trimethyl-5-pyrimidine carbonyl chloride to obtain the compounds 4a-4c.Then 4a-4c was reacted with 1a-1d,2a-2c,3a-3c to give the target compounds \u21601-\u216015.Furthermore,the antiviral activity and cell cytotoxicity of these compounds were evaluated with HIV-1 R5 strain in vitro.The results showed that all the target compounds exhibited potent antiviral activity against HIV-1 R5 strain(IC50=1.20-66.24 \u03bcmol \u00b7 L-1).Preliminary analysis of the structure-activity relationship showed that some compounds with an aryl group and the 1,3-diamino-propane structure between two N atoms exhibited improved anti-HIV-1 activity.This study provides several clues for designing new anti-HIV-1 fusion inhibitors.",
        "keywords": [
            "CCR5",
            "synthesis",
            "inhibitor",
            "HIV-1"
        ],
        "authors": [
            {
                "name": "MAO Wen-xiang",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,China;Institute of Biotechnology,Academy of Military Medical Science,Beijing ,China"
            },
            {
                "name": "DONG Ming-xin",
                "org": "Institute of Biotechnology,Academy of Military Medical Science,Beijing ,China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,China"
            },
            {
                "name": "JIANG Shi-bo",
                "org": "Key Laboratory of Medical Molecular Virology of MoE/MoH,Institute of Medical Microbiology, Shanghai Medical College,Fudan University,Shanghai ,China"
            },
            {
                "name": "DAI Qiu-yun",
                "org": "Institute of Biotechnology,Academy of Military Medical Science,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Medicinal Chemistry",
        "year": 2011
    },
    "8rIPU6Xj": {
        "id": "8rIPU6Xj",
        "title": "Synthesis and optoelectronic properties of a carbazole-modified platinum(II) complex in polymer light-emitting devices.",
        "abstract": "To improve opto-electronic properties and efficiently suppress excimer emission, a phenylpyridine (ppy)-based platinum(II) complex (C(16)OCz-ppy)Pt(acac) was synthesized and characterized, where C(16)OCz-ppy is a 2-phenylpyridine derivative appending a carbazole moiety and three hexadecyloxy methyl units in the parent phenylpyridine, and acac is acetylacetone. This carbazole-modified platinum(II) complex exhibited good thermal stability and three times higher photoluminescent quantum yield than its parent (2-phenylpyridine-C(2),N)(2,4-pentanedionato-O,O)platinum(II) complex [(ppy)Pt(acac)]. Single-emissive-layer polymer light-emitting devices using (C(16)OC(Z)-ppy)Pt(acac) as dopant and a blend of poly(N-vinylcarbazole) and 2-(4-biphenyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole as host matrix presented a maximum current efficiency of 1.51 cd A(-1), which was 1.5 times higher than that from the (ppy)Pt(acac)-doped device with the same device structure. Little excimer emission and minor aggregation emission were observed in the (C(16)OC(Z)-ppy)Pt(acac)-doped PLEDs at different dopant concentrations and applied voltages. This work indicates that introducing a carbazole and three hexadecyloxy methyl groups into the planar platinum(II) complex can reduce molecular aggregation and excimer emissions, thus resulting in high luminance and stable EL spectra in comparison with the parent (ppy)Pt(acac).",
        "keywords": [],
        "authors": [
            {
                "name": "Jian Luo",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan, 411105, China."
            },
            {
                "name": "Yu Liu",
                "org": ""
            },
            {
                "name": "Danyan Shi",
                "org": ""
            },
            {
                "name": "Yafei Wang",
                "org": ""
            },
            {
                "name": "Zhiyong Zhang",
                "org": ""
            },
            {
                "name": "Junting Yu",
                "org": ""
            },
            {
                "name": "Gangtie Lei",
                "org": ""
            },
            {
                "name": "Qing Chen",
                "org": ""
            },
            {
                "name": "Jianmin Li",
                "org": ""
            },
            {
                "name": "Xianping Deng",
                "org": ""
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            }
        ],
        "venue": "Dalton transactions (Cambridge, England : 2003)",
        "year": 2012
    },
    "DBLkHTCp": {
        "id": "DBLkHTCp",
        "title": "Study on the Influence of End Group on the Optophysical Performance of the Polyfluorene Derivatives Containing D-A Structure and Red Phosphorescent Group",
        "abstract": "Two donor(D)-acceptor(A)-based polyfluorene derivatives(P1and P2),which contain carriertransporting units of carbazole,oxadiazole and the red-emitting iridium bi(phenyliso-quilonato)(picolinato) unit as the substitutes of the C-9position of fuorene by unconjugated linkage were synthesized and characterized.Their opto-electronic properties were significantly influenced by the end-capping groups,the P1endcapped with the oxadiazole unit exhibit significantly decreased excimer emission.In the polymer light-emitting devices with a configuration of ITO/PEDOT/polymers/LiF/Al,the P1showed best electroluminescent properties than the P2.The maximum current efficiency of 0.54cd/A was obtained in the P1-based device,which are 1.42times higher than that in the P2-based device.Our work indicated that end-capping manners can improve EL properties of 2,7-polyfluorene derivatives.",
        "keywords": [
            "conjugated polymers",
            "fluorine",
            "end group",
            "photoelectric properties"
        ],
        "authors": [
            {
                "name": "QIN Zhi-jun",
                "org": "Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education,College of Chemistry,Xiangtan University,Xiangtan  China"
            },
            {
                "name": "TAN Hua",
                "org": "Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education,College of Chemistry,Xiangtan University,Xiangtan  China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": "Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education,College of Chemistry,Xiangtan University,Xiangtan  China"
            }
        ],
        "venue": "Natural Science Journal of Xiangtan University",
        "year": 2012
    },
    "5NMKTUt7": {
        "id": "5NMKTUt7",
        "title": "Structure and Properties of Oxadiazole Derivatives as a New Class of Cyclometalating Ligands",
        "abstract": "Five 2,5-diaryl-1,3,4-oxadiazole derivatives used as a new class of cyclometlating ligands were synthsized. Their molecular structures were characterized by IR, 1H NMR and element analysis. Furthermore, their spectroscopic, thermal and electrochemical properties were investigated by UV spectroscopy, fluorescence spectroscopy, differential scanning calorimetry(DSC) and cyclic voltammetry(CV), respectively. The results showed that the maximum UV absorption wavelengths of those 1,3,4-oxadiazole derivatives in dichloromethane were in the range of 268~327 nm, and their maximum photoluminescent wavelengths in dichloromethane and solid film were located at 332~390 nm and 359~439 nm, respectively. The 1,3,4-oxadiazole derivatives exhibit a first endothermal peak at 120~328 \u2103 in the DSC heating process, and the symmetrical 1,3,4-oxadiazole derivatives display a higher melting temperature. The CV curves of those 1,3,4-oxadiazole derivatives indicate that the reductive potentials of the 1,3,4-oxadiazole derivatives are located at -1.03~-0.98 V, and their LUMO(the lowest unoccoupied molecual orbit) energy levels are -3.71~-3.76 eV.",
        "keywords": [
            "oxadiazole derivate",
            "property",
            "chemical structure",
            "cyclomedtalating ligand"
        ],
        "authors": [
            {
                "name": "DENG Ji-Yong",
                "org": "College of Chemistry,Xiangtan University,Xiangtan "
            },
            {
                "name": "LIU Yu",
                "org": "College of Chemistry,Xiangtan University,Xiangtan "
            },
            {
                "name": "HU Zheng-Yong",
                "org": "College of Chemistry,Xiangtan University,Xiangtan "
            },
            {
                "name": "ZHU Mei-Xiang",
                "org": "College of Chemistry,Xiangtan University,Xiangtan "
            },
            {
                "name": "ZHU Wei-Guo",
                "org": "College of Chemistry,Xiangtan University,Xiangtan "
            }
        ],
        "venue": "Chinese Journal of Applied Chemistry",
        "year": 2007
    },
    "pUF0PE6D": {
        "id": "pUF0PE6D",
        "title": "Highly efficient red emission from binuclear cyclo-metalated platinum complexes bridged with 5-aryloxadiazole-2-thiol in PLEDs",
        "abstract": "A novel red-emitting binuclear platinum complex (dfppy)2Pt2(C8OXT)2 was synthesized and characterized, in which dfppy represents 2-(4\u2032,6\u2032-difluorophenyl)pyridinato unit and C8OXT is abbreviated for 5-(4-octyloxy-phenyl)-1,3,4-oxadiazole-2-thiol as a bridging ancillary ligand. Its photophysical, electrochemical and electroluminescent characteristics were primarily studied. The made single-emissive-layer (SEL) polymer light-emitting devices using (dfppy)2Pt2(C8OXT)2 as emitter exhibited a saturated red emission peaked at 620 nm. The best device performances were obtained in the device at 8 wt% dopant concentration, with a maximum external quantum efficiency of 8.4%, a current efficiency of 4.2 cd/A and brightness of 3228 cd/m2 . This work provides an effective approach to obtain high-efficiency red emission through construction of new binuclear platinum complex and its doped SEL devices.",
        "keywords": [
            "polymer electroluminescent light-emitting diode",
            "binuclear platinum complexes",
            "red emission",
            "oxadiazole"
        ],
        "authors": [
            {
                "name": "YU JunTing",
                "org": ""
            },
            {
                "name": "WU XiuGang",
                "org": ""
            },
            {
                "name": "TAN Hua",
                "org": ""
            },
            {
                "name": "WANG YaFei",
                "org": ""
            },
            {
                "name": "LIU Yu",
                "org": ""
            },
            {
                "name": "ZHU MeiXiang",
                "org": ""
            },
            {
                "name": "ZHU WeiGuo",
                "org": ""
            }
        ],
        "venue": "Scientia Sinica(Chimica)",
        "year": 2013
    },
    "3fKwVWbq": {
        "id": "3fKwVWbq",
        "title": "Saturated Red Polymer Electrophosphorescent Devices with meso-Tetrakis(4-n-decanoyl-phenyl) Porphyrin Platinum(\u2161) Complex as Emitter",
        "abstract": "The saturated red polymer electrophosphorescent devices have been fabricated.With the device structures of ITO/PEDOT\u2236 PSS/PVK/PFO+30%PBD\u2236 TDPPPt/Ca/Al(ITO:indium tin oxide,PEDOT:poly(3,4-ethylenedioxythiophene),PSS:poly(styrenesulfonate),PVK:poly N-vinyl carbazole),based on short lifetime meso-tetrakis(4-n-decanoyl-phenyl) porphyrin platinum(\u2161) complex(TDPPPt) and poly(2,7-9,9-dioctylfluorene)(PFO) in which 30% 2-(bi-phenyl-4-yl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole(PBD) was doped.The saturated red emission is obtained when doping concentration of TDPPPt is 3%~10%.The CIE(Commission Internationale de L\u2032Eclairage) coordinates of the device is about at(0.66,0.28) and unchangeable when driven voltage increases from 7 V to 14 V.The maximum luminance and luminance efficiency(\u03b7l) is 1 390 cd/m2 at 18 V and 1.34 cd/A at 18\u00d710-3 A/cm2,respectively.Furthermore,the devices show excellent stability under high driven current density.\u03b7l only drops to 88% and 73% of maximum efficiency at 100\u00d710-3 A/cm2,and 150\u00d710-3 A/cm2,respectively.We tentatively attribute excellent devices stability under high driven current density to the short radiative lifetime that avoids triplet-triple annihilation.",
        "keywords": [
            "meso-tetrakis(n-decanoyl-phenyl) porphyrin platinum(\u2161)",
            "polymer electrophosphorescent devices",
            "phosphorescent lifetime"
        ],
        "authors": [
            {
                "name": "LUO Kaijun",
                "org": "College of Chemistry and Materials,Sichuan Normal University,Chengdu "
            },
            {
                "name": "JIANG Shiping",
                "org": "College of Chemistry and Materials,Sichuan Normal University,Chengdu "
            },
            {
                "name": "ZHANG Lifang",
                "org": "College of Chemistry and Materials,Sichuan Normal University,Chengdu "
            },
            {
                "name": "ZHU Weiguo",
                "org": "College of Chemistry,Xiangtan University,Xiangtan"
            },
            {
                "name": "WANG Xin",
                "org": "College of Chemistry and Materials,Sichuan Normal University,Chengdu "
            }
        ],
        "venue": "Chinese Journal of Applied Chemistry",
        "year": 2011
    },
    "EU7Tfjdx": {
        "id": "EU7Tfjdx",
        "title": "Study on the Recycling of 4-Chloro-6-methoxypyrimidine",
        "abstract": "4-Chloro-6-methoxypyrimidine(CMP) is a main by-product resulted in the production process of fungicide azoxystrobin.Recovery of CMP by reaction with bis(trichloromethyl)carbonate to the formation of 4,6dichloropyrimidine was developed.The optimal reaction conditions were obtained with the molar ratio of CMP to DMF and BTC to CMP were 1 to 3 and 1 to 1,respectively,and rthe reaction was run at 100\u2103 for two hours.The process has various advantages,including easy operation,environmentally friendly,good yields and convenient for scaled production.",
        "keywords": [
            "4-chloro-6-methoxypyrimidine",
            "azoxystrobin",
            "4",
            "6-dichloropyrimidine"
        ],
        "authors": [
            {
                "name": "PENG Zhi-hai",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,China;National Engineering Research Center for Agrochemicals,Hunan Research Institute of Chemical Industry,Changsha ,China;Hunan Province Key Laboratory for Agrochemicals,Changsha ,China"
            },
            {
                "name": "LIU Wei-dong",
                "org": "National Engineering Research Center for Agrochemicals,Hunan Research Institute of Chemical Industry,Changsha ,China;Hunan Province Key Laboratory for Agrochemicals,Changsha ,China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,China"
            },
            {
                "name": "DU Sheng-hua",
                "org": "National Engineering Research Center for Agrochemicals,Hunan Research Institute of Chemical Industry,Changsha ,China;Hunan Province Key Laboratory for Agrochemicals,Changsha ,China"
            }
        ],
        "venue": "Fine Chemical Intermediates",
        "year": 2013
    },
    "1YHYPK4e": {
        "id": "1YHYPK4e",
        "title": "Synthesis and optoelectronic properties of a heterobimetallic Pt(II)-Ir(III) complex used as a single-component emitter in white PLEDs.",
        "abstract": "To tune aggregation/excimer emission and obtain a single active emitter for white polymer light-emitting devices (PLEDs), a heterobimetallic Pt(II)-Ir(III) complex of FIr(pic)-C(6)DBC(6)-(pic)PtF was designed and synthesized, in which C(6)DBC(6) is a di(phenyloxyhexyloxy) bridging group, FIr(pic) is an iridium(III) bis[(4,6-difluorophenyl)pyridinato-N,C(2)'] (picolinate) chromophore and FPt(pic) is a platinum(II) [(4,6-difluorophenyl)pyridinato-N,C(2)'] (picolinate) chromophore. Its physical and opto-electronic properties were investigated. Interestingly, the excimer emission was efficiently controlled by this heterobimetallic Pt(II)-Ir(III) complex compared to the PL profile of the mononuclear FPt(pic) complex in the solid state. Near-white emissions were obtained in the single emissive layer (SEL) PLEDs using this heterobimetallic Pt(II)-Ir(III) complex as a single dopant and poly(vinylcarbazole) as a host matrix at dopant concentrations from 0.5 wt% to 2 wt%. This work indicates that incorporating a non-planar iridium(III) complex into the planar platinum(II) complex can control aggregation/excimer emissions and a single phosphorescent emitter can be obtained to exhibit white emission in SEL devices.",
        "keywords": [],
        "authors": [
            {
                "name": "Xiaoshuang Li",
                "org": "College of Chemistry, Key Laboratory of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan, China."
            },
            {
                "name": "Yu Liu",
                "org": ""
            },
            {
                "name": "Jian Luo",
                "org": ""
            },
            {
                "name": "Zhiyong Zhang",
                "org": ""
            },
            {
                "name": "Danyan Shi",
                "org": ""
            },
            {
                "name": "Qing Chen",
                "org": ""
            },
            {
                "name": "Yafei Wang",
                "org": ""
            },
            {
                "name": "Juan He",
                "org": ""
            },
            {
                "name": "Jianming Li",
                "org": ""
            },
            {
                "name": "Gangtie Lei",
                "org": ""
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            }
        ],
        "venue": "Dalton transactions (Cambridge, England : 2003)",
        "year": 2012
    },
    "VqdRd4J3": {
        "id": "VqdRd4J3",
        "title": "Synthesis and Photophysical Properties of Europium Complexes Containing 2,5-Biaryl-1,3,4-Oxadiazole Ligand",
        "abstract": "A series of europium complexes based on 2,5-biaryl-1,3,4-oxadiazole ligands were synthesized and their luminescence properties were discussed.The results revealed that:(1) Europium complexes had a strong UV absorbance at the wavelength of 290~350 nm,and showed the characteristic PL spectrum of europium ion(613 nm);(2) The structures of ligands had a critical role influence on PL intensity of europium complexes;the maximal excited wavelength from the film of europium complexes had a blue shift of about 60 nm than that from the same europium complexes in solution.Electroluminescence studies indicated that devices using Eu(DBM)3R-OXD as guest and PVK as a host had a maximal brightness of 15 cd/m2 and the brightness of OELD depended strongly on the structures of europium complexes.Eu(DBM)3MeO-OXD had a stronger PL intensity than that of Eu(DBM)3F-OXD,and the EL intensity of Eu(DBM)3MeO-OXD was only one fourth of that of Eu(DBM)3F-OXD.The results proved that modifying the structure of ligands could optimize the luminescence properties of europium complexes.",
        "keywords": [
            "europium complexes",
            "electroluminescent device",
            "photoluminescence",
            "synthesis"
        ],
        "authors": [
            {
                "name": "LIANG Bo",
                "org": "School of Automobile and Mechanic Engineering,Changsha University of Science & Technology,Changsha ;College of Chemistry,Xiangtan University,Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education,Xiangtan  China"
            },
            {
                "name": "WU Zhong-lian",
                "org": "College of Chemistry,Xiangtan University,Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education,Xiangtan  China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": "College of Chemistry,Xiangtan University,Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education,Xiangtan  China"
            }
        ],
        "venue": "Natural Science Journal of Xiangtan University",
        "year": 2009
    },
    "nkloqjaV": {
        "id": "nkloqjaV",
        "title": "Study on the Recycling of 3-(\u03b1-Methoxy)methylenebenzo-furan-2(3H)-one",
        "abstract": "3-(\u03b1-Methoxy)methylenebenzo-furan-2(3H)-one,an intermediate for azoxystrobin,was synthesized from 3-(\u03b1-hydroxy)methylenebenzo-furan-2(3H)-one and methanol catalyzed by concentrated sulfuric acid.The effects of the reaction conditions were investigated,and the optimum results were obtained.The process has various advantages,including moderate reaction conditions,short reaction time,good yields and purity and convenient for scaled production.",
        "keywords": [
            "azoxystrobin",
            "3-(\u03b1-methoxy)methylenebenzo-furan-2(3H)-one",
            "synthesis"
        ],
        "authors": [
            {
                "name": "DENG Jian-wen",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,China;National Engineering Research Center for Agrochemicals,Hunan Research Institute of Chemical Industry,Changsha ,China;Hunan Province Key Laboratory for Agrochemicals,Changsha ,China"
            },
            {
                "name": "LIU Wei-dong",
                "org": "National Engineering Research Center for Agrochemicals,Hunan Research Institute of Chemical Industry,Changsha ,China;Hunan Province Key Laboratory for Agrochemicals,Changsha ,China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,China"
            },
            {
                "name": "DU Sheng-hua",
                "org": "National Engineering Research Center for Agrochemicals,Hunan Research Institute of Chemical Industry,Changsha ,China;Hunan Province Key Laboratory for Agrochemicals,Changsha ,China"
            }
        ],
        "venue": "Fine Chemical Intermediates",
        "year": 2012
    },
    "V686UHF1": {
        "id": "V686UHF1",
        "title": "The Synthesis of 3,5-bis[5\u2032-(4\u2033-methoxyphemyl)-1\u2032,3\u2032,4-oxadiazole2\u2032-yl]-bromobenzene and Its Spectral Properties",
        "abstract": "An important intermediate for making electroluminescent materials,namely,5-bromo-1,3-Bis[(2-phenyl)-5-(4\u2032-methoxy-phenyl)]-1,3,4-oxadiazole,was synthesized by using 5-amino-1,3-benzenedicarboxylic acid and 4-methoxy benzoyl hydrazine as raw materials and undergoing a serial of reactions,such as diazotization,acylchloride,diarylhydrazide and dehydration.The yield of the dehydrated reaction was 53.2%.Its structure was characterized with IR,1 H NNR. The influences of reactive conditions on the synthesis,UV spectrum and the fluorescence properties were investigated.The result shows that the CH3Cl solution of this compound had a maximum UV absorption wavelength of 307 nm and a peak fluorescent wavelength of 376 nm.",
        "keywords": [
            "electrophosphorescent materials",
            "5-amino-1",
            "oxadiazole derivatives",
            "3-benzenedicarboxylic acid",
            "synthesis",
            "organic chemistry"
        ],
        "authors": [
            {
                "name": "XING Kong-qiang",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,Hunan,China;Department of Chemistry,Qiongzhou University,Wuzhishan ,Hainan,China"
            },
            {
                "name": "LIU Yu",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,Hunan,China;Department of Chemistry,Qiongzhou University,Wuzhishan ,Hainan,China"
            },
            {
                "name": "ZHU Mei-xiang",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,Hunan,China"
            },
            {
                "name": "GAN Quan",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,Hunan,China"
            },
            {
                "name": "YANG Yu-ping",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,Hunan,China"
            },
            {
                "name": "WANG Xia-yu",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,Hunan,China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,Hunan,China"
            }
        ],
        "venue": "Journal of Central South University of Forestry & Technology",
        "year": 2007
    },
    "909U6WeR": {
        "id": "909U6WeR",
        "title": "Structure-activity relationships of novel HIV-1 gp41 fusion peptide CP32M",
        "abstract": "Objective To probe the effect of length,electric charge and fragment replacement of the key domain VEWNEMT and other residues in CP32M on its inhibitory activity to HIV-1 gp41 fusion.Methods Based on CP32M,a series of polypeptides of varied lengths and with electric charges and other functional fragments were designed and synthesized.The anti-HIV-1 activities were tested using HIV-1 \u2162B virus,and interaction with N36 was determined by circular dichroism spectrum and size-exclusion HPLC.Results Truncation and partial residue replacement in the fragment VEWNEMT or introduction of i to i+4 Glu-Lys ion pair interaction in the center or at C terminus of CP32M resulted in a decrease in the anti-HIV-1 activity of gp41 and the content of \u03b1-helix.The substitution of VEWNEMT by the fragment NEKDLLE derived from C terminus of C34 and a gp120 binding peptide RINNIPWSEAM rescued the inhibitory activity.Conclusion VEWNEMT is the key fragment for CP32M,and residues VE and MT are crucial functional amino acids.The replacement of VEWNEMT by other functional domain retains high anti-HIV-1 activity and high content of helical structure,suggesting that this fragment contains a commons binding area.",
        "keywords": [
            "CP32M",
            "polypeptide",
            "structure-activity relationship",
            "HIV envolope protein gp41",
            "HIV-1"
        ],
        "authors": [
            {
                "name": "WANG Xiao-hua",
                "org": "College of Chemistry,Xiangtan University,Xiangtan,Hunan ,China;Institute of Biotechnology,Academy of Military Medical Sciences,Beijing ,China"
            },
            {
                "name": "CHENG Jian-wei",
                "org": "Institute of Biotechnology,Academy of Military Medical Sciences,Beijing ,China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": "College of Chemistry,Xiangtan University,Xiangtan,Hunan ,China"
            },
            {
                "name": "DONG Ming-xin",
                "org": "Institute of Biotechnology,Academy of Military Medical Sciences,Beijing ,China"
            },
            {
                "name": "ZHONG Hui-hui",
                "org": "Institute of Pathogen Biology,Chinese Academy of Medical Science & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "HE Yu-xian",
                "org": "Institute of Pathogen Biology,Chinese Academy of Medical Science & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "DAI Qiu-yun",
                "org": "Institute of Biotechnology,Academy of Military Medical Sciences,Beijing ,China"
            }
        ],
        "venue": "Military Medical Sciences",
        "year": 2012
    },
    "aD5A11Yg": {
        "id": "aD5A11Yg",
        "title": "Quantificational Administration of the Postgraduate Education in Chemistry Major",
        "abstract": "This paper presents the necessity of quantificational administration for postgraduate education based on the educating aim and requirement during postgraduate education in chemistry major.To promote the postgraduate educating quality in our country,a quantification judging system for postgraduate education in this major is constructed according to the characteristic of educating process under the guidance of science evolutive theory.",
        "keywords": [
            "chemistry major",
            "assessing system",
            "postgraduate",
            "quantificational administration"
        ],
        "authors": [
            {
                "name": "ZHU Wei-guo",
                "org": "Chemistry College of Xiangtan University,Xiangtan ,Hunan China"
            },
            {
                "name": "ZHOU Ji",
                "org": "Chemistry College of Xiangtan University,Xiangtan ,Hunan China"
            }
        ],
        "venue": "Journal of Jishou University(Natural Sciences Edition)",
        "year": 2008
    },
    "CF9DPzY5": {
        "id": "CF9DPzY5",
        "title": "The synthesis of 5-bromo-1,3-bis2-(4\u2032-tert-butylbenzene)-1,3,4-(oxadiazol-5-yl) benzene",
        "abstract": "A new electrophosphorescent intermediate,5-bromo-1,3-bis2-(4\u2032-tert-butylbenzene)-1,3,4-(oxadiazol-5-yl)benzene was synthesized by using 5-amino-1,3-benzenedicarboxylic acid and 4-tert-butylbenzoyl hydrazine.The influence of reaction conditions on synthesis was investigated.The overall yield arrived at 20%.",
        "keywords": [
            "3",
            "4-(oxadiazol-5-yl) benzene",
            "3-bis2-(4\u2032-tert-butylbenzene)-1",
            "synthesis",
            "5-bromo-1",
            "electrophosphorescence"
        ],
        "authors": [
            {
                "name": "GAN Quan",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,China"
            },
            {
                "name": "XING Kong-qiang",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,China;Department of Chemistry,Qiongzhou University,Wuzhishan ,China"
            },
            {
                "name": "LIU Yu",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,China;Department of Chemistry,Qiongzhou University,Wuzhishan ,China"
            },
            {
                "name": "WU Zhong-lian",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,China"
            },
            {
                "name": "ZHU Mei-xiang",
                "org": "The Editorial Department,Xiangtan University,Xiangtan ,China"
            },
            {
                "name": "FENG Jian-liang",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": ""
            }
        ],
        "venue": "Chemical Reagents",
        "year": 2005
    },
    "FOUE6hMB": {
        "id": "FOUE6hMB",
        "title": "Metallomesogens based on platinum(II) complexes: synthesis, luminescence and polarized emission.",
        "abstract": "Two series of heteroleptic cyclometalated platinum(II) complexes [(C(n)Oppy)Pt(acac) and (C(n)OFppy)Pt(acac)] have been prepared. Their liquid-crystal and optophysical properties were studied, in which C(n)Oppy is 2-(4-alkoxyphenyl)-5-(alkoxymethyl)pyridine and C(n)OFppy is 2-(3-fluoro-4-alkoxyphenyl)-5-(alkoxymethyl)pyridine. Only the heteroleptic cyclometalated platinum(II) complexes (n = 12 and 16) exhibited enantiotropic mesophase transitions with smectic (S(m)) structure. Intense polarized luminescence with a maximum peak at 532 nm and a polarization ratio as high as 10.5 were obtained in an aligned polyimide film under opto-excitation at room temperature. This research work provides a simple approach to realize high-efficiency polarized emission by heteroleptic cyclometalated platinum(II) complexes.",
        "keywords": [],
        "authors": [
            {
                "name": "Yafei Wang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yu Liu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Jian Luo",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Hongrui Qi",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Xiaoshuang Li",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Meijun Nin",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Ming Liu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Danyan Shi",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yong Cao",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            }
        ],
        "venue": "Dalton transactions (Cambridge, England : 2003)",
        "year": 2011
    },
    "udeHxCfX": {
        "id": "udeHxCfX",
        "title": "Efficient Green Phosphorescent Polymer Light-emitting Diodes Based on Cyclometalated Iridium Complex",
        "abstract": "A novel iridium complex with sterically bulky camphor-derives group as \u03b2-diketonate,i.e.,(2-phenylpyridinato-N,C2\u2032) irdium(\u2162)(3-acetyl-camphor) [Ir(ppy)2(acam)],was synthesized and it was characterized by 1H NMR,ESI-MS,and elementary analysis.This complex exhibited a higher phototoluminescence quantum efficiency(0.54) than(2-phenylpyridinato-N,C2\u2032) irdium(\u2162)(acetylacetonate) [Ir(ppy)2(acac)](0.34) in 2-methyl-tetrahydrofuran solution.Efficient green phosphorescent polymer light-emitting diodes using Ir(ppy)2(acam) as dopants showed high efficiencies and stable EL spectra,with maximum current efficiency of 15.1 cd/A,maximum power efficiency of 4.23 lm/W and maximum brightness of 9 939 cd/m2 at doping mass fraction of 1%.",
        "keywords": [
            "Camphor-derives group",
            "Iridium complex",
            "Phosphorescence",
            "PLEDs",
            "Synthesis"
        ],
        "authors": [
            {
                "name": "LUO Kai-jun",
                "org": "College of Chemistry and Materials,Sichuan Normal University,Chengdu ,China"
            },
            {
                "name": "JIANG Shi-ping",
                "org": "College of Chemistry and Materials,Sichuan Normal University,Chengdu ,China"
            },
            {
                "name": "WANG Xin",
                "org": "College of Chemistry and Materials,Sichuan Normal University,Chengdu ,China"
            },
            {
                "name": "DENG Xian-ping",
                "org": "College of Chemistry,Key Laboratory of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan University,Xiangtan ,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "ZHAO Ke-qing",
                "org": "College of Chemistry and Materials,Sichuan Normal University,Chengdu ,China"
            },
            {
                "name": "XIE Yun",
                "org": "College of Chemistry and Materials,Sichuan Normal University,Chengdu ,China"
            }
        ],
        "venue": "Chinese Journal of Luminescence",
        "year": 2011
    },
    "OxJwgz9S": {
        "id": "OxJwgz9S",
        "title": "Synthesis of new iridium complexes and their electrophosphorescent properties in polymer light-emitting diodes",
        "abstract": "",
        "keywords": [
            "light emitting diode"
        ],
        "authors": [
            {
                "name": "Weiguo Zhu",
                "org": ""
            },
            {
                "name": "Chuanzhen Liu",
                "org": ""
            },
            {
                "name": "Lijun Su",
                "org": ""
            },
            {
                "name": "Wei Yang",
                "org": ""
            },
            {
                "name": "Ming Yuan",
                "org": ""
            },
            {
                "name": "Yong Cao",
                "org": ""
            }
        ],
        "venue": "Journal of Materials Chemistry",
        "year": 2003
    },
    "lA3PF5DP": {
        "id": "lA3PF5DP",
        "title": "Synthesis and Electrophosphorescent Properties of a Novel Iridium Complex with Arylamine Unit in the Polymer Light-emitting Devices",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Zhonglian Wu",
                "org": ""
            },
            {
                "name": "Kongqiang Xing",
                "org": ""
            },
            {
                "name": "Cuiping Luo",
                "org": ""
            },
            {
                "name": "Yu Liu",
                "org": ""
            },
            {
                "name": "Yuping Yang",
                "org": ""
            },
            {
                "name": "Quan Gan",
                "org": ""
            },
            {
                "name": "Meixiang Zhu",
                "org": ""
            },
            {
                "name": "Changyun Jiang",
                "org": ""
            },
            {
                "name": "Yong Cao",
                "org": ""
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            }
        ],
        "venue": "Chemistry Letters",
        "year": 2006
    },
    "EwiHhyB5": {
        "id": "EwiHhyB5",
        "title": "Synthesis and red electrophosphorescence of a novel cyclometalated iridium complex in polymer light-emitting diodes",
        "abstract": "The preparation and characterization of a new cyclometalated iridium complex with 2-(1-naphthalene) pyridine ligand were reported. An electrophosphorescent device was fabricated by using this new iridium complex as guest and poly-(cyano-paraphenylene) as host. Red electrophosphorescence was observed with an emission peak at approximately 600 nm. An external quantum efficiency of 1.3% was achieved in this electrophosphorescent polymer light-emitting devices.",
        "keywords": [
            "polymer light-emitting diodes",
            "iridium complex",
            "electrophosphorescence",
            "optoelectronic device",
            "external quantum efficiency",
            "light emitting diode"
        ],
        "authors": [
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Yong Ke",
                "org": "Institute of Polymer Optoelectronics Materials and Devices, South China University of Technology, Guangzhou 510640, PR China"
            },
            {
                "name": "Lijun Su",
                "org": "Institute of Polymer Optoelectronics Materials and Devices, South China University of Technology, Guangzhou 510640, PR China"
            },
            {
                "name": "Min Yuan",
                "org": "Institute of Polymer Optoelectronics Materials and Devices, South China University of Technology, Guangzhou 510640, PR China"
            },
            {
                "name": "Yong Cao",
                "org": ""
            }
        ],
        "venue": "Thin Solid Films",
        "year": 2004
    },
    "6YjouGKa": {
        "id": "6YjouGKa",
        "title": "Significantly improved photovoltaic performances of the dithiophene-benzothiadiazole-alt-fluorene copolymers by incorporating carbazole units in fluorene moiety",
        "abstract": "To exploit an effective way to improve polymeric photovoltaic performance, a series of dithiophene-benzothiadiazole-alt-fluorene copolymers containing carbazole groups at C-9 positions of the alternating fluorene units (PFO-FCz-DBT) were synthesized and characterized. The effect of the carbazole groups on the optophysical, electrochemical, and photovoltaic properties of these copolymers was investigated. By comparison, this type of copolymers with carbazole units exhibited significantly improved photovoltaic properties than poly(2,7-(9,9-dioctyl-fluorene)-alt-5,5-(4\u2032,7\u2032-di-2-thienyl- 2\u2032,1\u2032,3\u2032-benzothiadiazole) (PFO-DBT) in the bulk heterojunction solar cells. A maximum power-conversion efficiency (PCE) of 2.41% and a highest short-circuit current density (Jsc) of 9.68 mA cm -2 were obtained for the PFO-FCz-DBT30, which are about two times higher than the corresponding levels for the PFO-DBT30. This work demonstrated that introducing a hole-transporting carbazole unit into copolymer is a simple and effective method to improve the Jsc and PCE. Copyright \u00a9 2011 Wiley Periodicals, Inc.",
        "keywords": [
            "bulk heterojunction",
            "carbazole",
            "conjugated polymers",
            "copolymers",
            "dithiophene-benzothiadiazole-alt-fluorene",
            "functionalization of polymers",
            "photovoltaic performances",
            "solar cell",
            "structure-property relations"
        ],
        "authors": [
            {
                "name": "Ming Liu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yafei Wang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Zhiyong Zhang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Jianming Li",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yu Liu,",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Hua Tan",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Meijun Ni",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Gangtie Lei",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "Journal of Polymer Science, Part A: Polymer Chemistry",
        "year": 2011
    },
    "1echX4O7": {
        "id": "1echX4O7",
        "title": "Synthesis of Cyclometalated Platinum Complexes Containing Triarylamino Group and Their Photophysical and Electrochemical Properties",
        "abstract": "Two cyclomatetaled platinum(Pt)complexes containing triarylamine moiety were synthesized by Ullmann and cyclometalated reactions,which are [N,N-(4-tert-butylphenyl)-4-(2'-pyridyl)aniline-C 3,N 1](diphenoxylmethane)Pt(\u2161)and [N,N-diphenyl-4-(2'-pyridyl)aniline-C 3,N 1](diphenoxylmethane)Pt(\u2161).The influence of reaction condition and molecular structures on the synthesis was investigated.The cyclometalated yield was 87.0%.The spectral and electrochemical properties of these Pt complexes were also studied.The results showed that both complexes had intense UV-Vis absorption and photoluminescence properties.The oxidation and reduction potentials of(PhNPPy)Pt(DBM)and(BuPhNPPy)Pt(DBM)are 0.80,-1.63 V and 0.93,-1.45 V respectively.The maximum UV-Vis absorption and photoluminescence wavelengths of(PhNPPy)Pt(DBM)are 346 and 537 nm respectively and these of(BuPhNPPy)Pt(DBM)have a red-shifted wavelength of 7_13 nm.",
        "keywords": [
            "Electrochemical property",
            "Photoluminescence",
            "Pt complex",
            "Synthesis",
            "UV-Vis spectrum"
        ],
        "authors": [
            {
                "name": "LIU Jian",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,China"
            },
            {
                "name": "LIU Yu",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,China"
            },
            {
                "name": "CuiPing Luo",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "LIU En-Hui",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,China"
            },
            {
                "name": "YANG Yu-Ping",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,China"
            },
            {
                "name": "GAN Quan",
                "org": "College of Chemistry,Xiangtan University,Xiangtan ,China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "Chemical Journal of Chinese Universities",
        "year": 2006
    },
    "rytHM3Fx": {
        "id": "rytHM3Fx",
        "title": "Bipolar iridium dendrimers containing carbazolyl dendron and 1,2,4-triazole unit for solution-processed saturated red electrophosphorescence",
        "abstract": "Two solution-processable, carbazole-based iridium dendrimers (Ir-1 and Ir-2) were synthesized and characterized. The presence of carbazolyl substituent on the cyclometallated ligand resulted in improved solubility, good control over intermolecular interactions, and improved hole transport properties. The triazole ancillary ligand led to improved electron transport properties. When the dendrimers were employed as host-free light-emitting layers in the OLEDs, the devices exhibited a low turn-on voltage of 5.4 V. The maximal external quantum efficiencies and luminous efficiency of the devices obtained from Ir-1 and Ir-2 were 5.1% and 3.3 cd A-1 and 7.9% and 4.4 cd A-1, respectively, both with saturated red emission (CIE coordinates, 0.663, 0.332). The devices have a structure of indium tin oxide/poly(3,4- ethylenedioxythiophene)/dendrimer/1,3,5-tris(N-phenylbenzimiazole-2-yl)benzene/ cesium fluoride/aluminum. Given ease of synthesis and good device performance, these iridium dendrimers can be used to fully exploit the potential of low-cost OLEDs, leading to more applications in high-efficiency OLEDs. \u00a9 2013 Elsevier B.V. All rights reserved.",
        "keywords": [
            "bipolar transport",
            "dendrimer",
            "electrophosphorescent devices",
            "host-free oleds",
            "iridium complex",
            "solution-process"
        ],
        "authors": [
            {
                "name": "Bo Liang",
                "org": "Changsha University of Science and Technology(Changsha University of Science and Technology),Changsha,China"
            },
            {
                "name": "Sujun Hu",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            },
            {
                "name": "Yanping Liu",
                "org": "Changsha University of Science and Technology(Changsha University of Science and Technology),Changsha,China"
            },
            {
                "name": "Zhiqiang Fan",
                "org": "Changsha University of Science and Technology(Changsha University of Science and Technology),Changsha,China"
            },
            {
                "name": "Xueye Wang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Hongbin Wu",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            },
            {
                "name": "Yong Cao",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2013
    },
    "MkEccCzX": {
        "id": "MkEccCzX",
        "title": "Highly efficient electrophosphorescence from a grafted biscyclometalated iridium complex with triarylamine unit in polymer light-emitting devices",
        "abstract": "The electroluminescence performance from a novel grafted cyclometalated iridium complex (BuPhNPPy) 2Ir(acac) with triarylmine unit, where BuPhNPPy is N,N-di(4-tert-butylphenyl)-4-(2-pyridyl) phenylamine and Hacac is acetylacetone, is demonstrated in the double-layered polymer light-emitting devices (PLEDs). The PLEDs emit intense green phosphorescence at 533 nm with a shoulder peak of 566 nm employing 4 wt.% (BuPhNPPy) 2Ir(acac) doped a blend of poly(vinylcarbazole) (PVK) and 2-tert-butylphenyl-5-biphenyl-1,3,4- oxadiazole (PBD) as the emitting layer. A maximum luminance of 14610 cd/m 2 at voltage of 24 V and a maximum external quantum efficiency E ext of 10.4% photons per electron (ph/el) at current density of 32 mA/cm 2 are achieved. When the current density is raised to 100 mA/cm 2, E ext of the device still remained to 8.3% ph/el. This indicates that the triplet-triplet annihilation is restrained more effectively at high current density. The improvement of electrophosphorescence performances of the iridium complex may be contributed to an ortho-substituent effect of grafted triarylmine unit. \u00a9 2005 Chinese Physical Society and IOP Publishing Ltd.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Zhu Mei-Xiang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Wu Zhong-Lian",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Jiang Chang-Yun",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            },
            {
                "name": "Jian Liu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Li Jian-Ren",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Xing Kong-Qiang",
                "org": "Qiongzhou University(Qiongzhou University),Sanya,China"
            },
            {
                "name": "Yang Yu-Ping",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Quan Gan",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yong Cao",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            },
            {
                "name": "Zhu Wei-Guo",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2005
    },
    "UqnXlmgH": {
        "id": "UqnXlmgH",
        "title": "Synthesis, photoelectronic properties of the cyclometalated iridium(III) complexes with donor-acceptor structures",
        "abstract": "To obtain the rule of influence of donor(D)-acceptor(A) structures attached into iridium complexes by a non-conjugated connection on the optoelectronic properties of their iridium complexes, a series of cyclometalated iridium(III) complexes with D-A structures containing carbazole and oxadiazole units were synthesized, and their optoelectronic properties were also investigated. The results show that these D-A based iridium complexes exhibited better thermal stability, more intense red-shifted UV absorption peak, higher emission quantum yield, as well as improved electrochemical and electroluminescence properties, compared with the classical di[2-(4', 6'-diflurophenyl) pyridine-C2, N'](piconilic acid) iridium(III). Their maximum UV absorption and emission peaks located respectively at around 297 nm and 476 nm in dichloromethane, but the maximum emission peak shifted to (520\u00b16) nm in their neat films. In these iridium complexes, (t-Bu-OXDdfppy)2Ir(pic-Cz) presented a current efficiency of 2.5 cd/A in its doped polymer light-emitting devices, which is higher than that of the (dfppy)2Ir(pic) doped device with the same device configuration.",
        "keywords": [
            "Cyclometalated iridium complex",
            "Donor-acceptor",
            "Photoelectronic property",
            "Polymer light-emitting device",
            "Synthesis"
        ],
        "authors": [
            {
                "name": "Yunbo Cao",
                "org": "Ministry of Education China(Ministry of Education),Beijing,China"
            },
            {
                "name": "Yu Liu,",
                "org": "Ministry of Education China(Ministry of Education),Beijing,China"
            },
            {
                "name": "Liang Li",
                "org": "Ministry of Education China(Ministry of Education),Beijing,China"
            },
            {
                "name": "Aihui Liang",
                "org": "Ministry of Education China(Ministry of Education),Beijing,China"
            },
            {
                "name": "Hua Tan",
                "org": "Ministry of Education China(Ministry of Education),Beijing,China"
            },
            {
                "name": "Xiaoshuang Li",
                "org": "Ministry of Education China(Ministry of Education),Beijing,China"
            },
            {
                "name": "Meijun Ni",
                "org": "Ministry of Education China(Ministry of Education),Beijing,China"
            },
            {
                "name": "Ming Liu",
                "org": "Ministry of Education China(Ministry of Education),Beijing,China"
            },
            {
                "name": "Qiliang Wei",
                "org": "Ministry of Education China(Ministry of Education),Beijing,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Ministry of Education China(Ministry of Education),Beijing,China"
            }
        ],
        "venue": "Acta Chimica Sinica",
        "year": 2011
    },
    "ttMOtvP2": {
        "id": "ttMOtvP2",
        "title": "D-A-based polyfluorene derivatives end-capped with cyclometalated iridium complexes by unconjugated linkage: Structure-property relationships",
        "abstract": "A series of donor(D)-acceptor(A)-based polyfluorene derivatives, which contain carrier-transporting units of carbazole and oxadiazole as the substitutes of the C-9 position of uorene and are end-capped with the red-emitting iridium bi(phenylisoquilonato)(picolinato) unit by unconjugated linkage, were synthesized and characterized. The molar ratios between the donor of carbazole and the acceptor of oxadiazole moieties were found to significantly influence photoluminescent efficiency, electrochemical and electroluminescent properties of these D-A-based polyfluorene derivatives. While the ratio increased to 3:7, the PFCz3OXD7Ir showed the best device performance in the polymer light-emitting device with a configuration of ITO/PEDOT/polymers/LiF/Al. A turn-on voltage of 6.0 V, a maximum current efficiency of 0.59 cd/A and the highest luminance of 917 cd/m2 were presented. \u00a9 2011 Elsevier Ltd. All rights reserved.",
        "keywords": [
            "donor-acceptor",
            "electrophosphorescence",
            "polymer light-emitting devices",
            "electroluminescence"
        ],
        "authors": [
            {
                "name": "Hua Tan",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "JunTing Yu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Kaixuan Nie",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Jianhua Chen",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Xianping Deng",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Zhiyong Zhang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Gangtie Lei",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yu Liu,",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "Polymer",
        "year": 2011
    },
    "FImbABXf": {
        "id": "FImbABXf",
        "title": "Novel cyclometalated platinum (II) complex containing alkyl-trifluorene picolinic acid as emitter for single-layer white PLEDs",
        "abstract": "To explore the influence of molecular structure on formation excimers and obtain high-efficiency white polymer light-emitting devices, two novel blue-emitting cyclometalated platinum (II) complexes of (dfppy)Pt(Tfl-pic) and (C 16 dfppy)Pt(Tfl-pic) have been successfully synthesized and characterized, where dfppy is 2-(2,4-difluoro-phenyl)pyridine, C 16 dfppy is 5-hexdecanyl-2-(2,4-difluorophenyl)pyridine and Tfl-pic is alkyltrifluorene-containing picolinic acid derivative. Compare to (dfppy)Pt(pic), both of platinum (II) complexes exhibited high thermal stability, good solubility and excellent photoluminescent quantum efficiency (about 94% \u00b1 10%) at room temperature. Deep blue emission at about 418 nm in dilute dichloromethane (10 \u22125 M) and red-shifted emission at about 619 nm in the neat film were observed under opto-excitation. Pure white light with a CIE coordinates (0.33, 0.33) at 10 V was obtained in the (dfppy)Pt(Tfl-pic)-doped devices and a red emission was obtained in the (C 16 dfppy)Pt(Tfl-pic)-doped devices with the same device configuration using a blend of polyvinylcarbazole and 2-(4-biphenyl)-5-(4- tert -butylphenyl)-1,3,4-oxadiazole as a host matrix, respectively. Keywords Electrophosphorescence Platinum (II) complex White polymer light-emitting devices Excimers Synthesis 1 Introduction Recently, white organic light-emitting devices (WOLEDs) have attracted much increasing interest because of their potential applications in full color displays, back lighting of flat-panel displays and solid-state lighting [1\u201316] . An ideal white emission is generally composed of three primary colors (blue, green and red) and covers the whole visible range from 400 to 700 nm. So far, most of the reported white-emitting devices were multilayer configuration fabricated by consecutive evaporations or co-evaporation of different emission compounds [6\u20138] . However, this class of multilayer devices requires complicated processes, high cost and high turn-on voltage. Compared to the multilayer devices, the single-layer devices fabricated by a blend of different emitters with three primary colors have a more cost-effective. Nevertheless, this class of single-layer devices could have poor stability and can hardly get pure white emission due to phase separation and undesired F\u00f6rest energy transfer from the high-energy emitter to the low-energy one. In order to obtain high-efficiency single-layer WOLEDs, an effective method, in which planar blue-emitting platinum (II) complexes were used as emitter, has been developed in these years. The white emission results from a blend of itself blue short-wavelength emission and excimer\u2019s long-wavelength emission in these devices [3,17,18] . For example, Forrest et al. made a WOLED using a bidentate platinum (II) complex (FPt) doped into 1,3-bis(N-carbazolyl)-benzene (mCP) with a power efficiency of 8.1 lm W \u22121 [17] . Jabbour et al. used the same FPt complex as dopant to fabricate similar WOLEDs using a 2,6-bis(N-carbazolyl)pyridine (26mCPy) as a host with external quantum efficiency ( EQE ) of 15.9% and a power efficiency of 12.6 lm W \u22121 [18] . However, to our best knowledge, the reports on the platinum (II) complex-doped white polymer light-emitting devices (WPLEDs) are very rare [19\u201321] . With this mind, to study the influence of cyclometalated platinum (II) complexes on formation excimers in polymer host and obtain high-efficiency WPLEDs, we designed and synthesized a new ancillary ligand of the oligomer-fluorene-based picolinic acid derivative (Tfl-picH) and its heteroleptic platinum (II) complexes of (dfppy)Pt(Tfl-pic) and (C 16 dfppy)Pt(Tfl-pic), where dfppy is 2-(2,4-difluorophenyl)pyridine and C 16 dfppy is 5-hexdecanyl-2-(2,4-difluorophenyl)pyridine. The synthetic route of two platinum (II) complexes is shown in Scheme 1 . As oligomer-fluorene possesses a rigid \u043f-\u043f aryl system and good solubility [22] , it is expected to facilitate its square-planar platinum (II) complexes to form excimers in high concentration, even in thin films [23\u201325] . As expected, intense excimers\u2019s emissions were observed for these two platinum (II) complexes in their neat films under photo-excitation and in their-doped PLEDs under electronic-excitation. Significant influence of cyclometalated ligand on the excimer emission of its platinum (II) complexes was presented. Employing (dfppy)Pt(Tfl-pic) as guest, a blend of polyvinylcarbazole (PVK) and 2-(4-biphenyl)-5-(4- tert -butylphenyl) -1,3,4-oxadiazole (PBD) as a host matrix, the simple single-layer PLEDs exhibited pure white emission with the CIE coordinates (0.33, 0.33) at 10 V. In contrast, the (C 16 dfppy)Pt(Tfl-pic)-doped PLED with the same device configuration displayed only red emission with the CIE coordinate around (0.40, 0.41). 2 Results and discussion 2.1 Synthesis The trialkyl-fluorene-based picolinic acid (Tfl-picH) was prepared with a moderate yield based on the procedures [26] . The platinum (II) complexes of (dfppy)Pt(Tfl-pic) and (C 16 dfppy)Pt(Tfl-pic) were synthesized by two-step procedures with a chloride-bridged process of K 2 PtCl 4 with cyclometalated ligand and a chloride cleavage of the resulting chloro-bridged dimmers with the ancillary ligand of Tfl-picH in a moderate condition based on the literatures [27,28] . As this trifluoene-based ancillary ligand has a steric block and the platinum atom has a planar structure with a bigger atom radius, it was more difficult to gain (dfppy)Pt(Tfl-pic) and (C 16 dfppy)Pt(Tfl-pic) than (dfppy)Pt(pic). Both of platinum (II) complexes have been confirmed with 1 H NMR and elemental analysis. 2.2 Optical analysis Fig. 1 shows the UV\u2013vis absorption spectra of platinum (II) complexes in dilute dichloromethane (DCM, 10 \u22125 M) at room temperature and their UV absorption data are summarized in Table 1 . As shown in Fig. 1 , a moderate high-energy UV absorption band at 267 nm and much intense low-energy absorption bands at about 354 nm were observed for each of two alkyltrifluorene-based platinum (II) complexes. The influence of alkyltrifluorene-based picolinic acid on UV\u2013vis absorption property of its platinum (II) complex is similar to that of its iridium (III) complex reported in our previous work [26] . Compared to UV\u2013vis spectrum of (dfppy)Pt(pic), the high-lying absorption band is assigned to the intraligand-based \u03c0\u2013\u03c0 \u2217 transitions, and the low-lying absorption band is attributed to the mixed single and triplet metal-to-ligand charge transfer transitions (MLCT) for these alkyltrifluorene-based platinum (II) complexes [29] . Furthermore, the low-energy absorption of both alkyltrifluorene-based platinum (II) complexes are more intense than that of (dfppy)Pt(pic). This means that incorporating alkyl-trifluorene group into the common ancillary ligand of picolinic acid is available for enhancing UV absorption of its platinum (II) complexes and enlarges spectral overlap between UV absorption of platinum (II) complexes and PL of PVK employed as host matrix in the latter devices. The photoluminescence (PL) spectra of these three platinum (II) complexes are shown in Fig. 2 and their emission data are summarized in Table 1 . Nearly identical PL profiles containing an emission peaks at 396 nm with a shoulder at 418 nm are exhibited for these two alkyltrifluorene-based platinum (II) complexes (dfppy)Pt(Tfl-pic) and (C 16 dfppy)Pt(Tfl-pic) in dilute DCM (10 \u22125 M). Compared to PL spectrum of (dfppy)Pt(pic) in dilute DCM (10 \u22125 M), these two deep blue emission peaks are attributed to the emission of platinum (II) complexes. However, these two trifluorene-based platinum (II) complexes exhibited higher photoluminescent quantum yield (\u03a6 f ) than (dfppy)Pt(pic) in degassed DCM at room temperature. The \u03a6 f was determined to be 0.94 for (dfppy)Pt(Tfl-pic), 0.81 for (C 16 dfppy)Pt(Tfl-pic) and 0.58 for (dfppy)Pt(pic) by using 9,10-diphenylanthrancene as the standard (\u03a6 f = 0.9) [30] . Therefore, an introduction of alkyl-trifluorene group into the ancillary ligand of picolinic acid did improve the PL quantum efficiency of its platinum (II) complexes obviously. In contrary, the PL spectra of (dfppy)Pt(Tfl-pic) and (C 16 dfppy)Pt(Tfl-pic) in their neat films exhibit two emission peaks, respectively. The high-energy emission peak locates at 402 nm for (dfppy)Pt(Tfl-pic) and 421 nm for (C 16 dfppy)Pt(Tfl-pic) while the low-energy emission peak locates at 619 nm for the former and 569 nm for the latter. They are different from the PL spectrum of (dfppy)Pt(pic) in the neat film which exhibit only an emission peak at 601 nm. As we know, platinum (II) complexes have a planar molecular configuration and have a potential to form excimers and give the excimers emission in their neat film [31] . Compared to (dfppy)Pt(Tfl-pic), (C 16 dfppy)Pt(Tfl-pic) with a substituted alkyl chain in 2,4-difluorophenylpyridine presented obviously weak emission in long-wavelength area. The weak low-energy emission for (C 16 dfppy)Pt(Tfl-pic) may be relative to the excimer emission quenching resulting from facile aggregation by the flexibility of long alkyl chain in 2,4-difluorophenylpyridine core. 2.3 Thermal property The thermal stability of platinum (II) complexes was evaluated by thermogravimetric analysis (TGA) under N 2 stream with a scanning rate of 20 \u00b0C/min and their TGA curves are shown in Figure S1. The decomposition temperature (T d ) values are 292 \u00b0C for (dfppy)Pt(Tfl-pic), 295 \u00b0C for (C 16 dfppy)Pt(Tfl-pic) and 294 \u00b0C for (dfppy)Pt(pic), which correspond to a 5% weight loss. This result suggests incorporating a trifluorene group into picolinic acid has a minor effect on thermal stability of its platinum (II) complexes. 2.4 Electrochemical property The electrochemical behavior of these cyclometalated platinum (II) complexes was studied by cyclic voltammetry using ferrocene as the internal standard and their data are listed in Table 1 . Irreversible oxidation peaks were found from each compound. On the basis of these onset oxidation potentials (E ox ) and formula E HOMO = E ox + 4.34 eV, the highest occupied molecular orbital energy levels (E HOMO ) of (dfppy)Pt(Tfl-pic) and (C 16 dfppy)Pt(Tfl-pic) were calculated as \u22126.28 and \u22125.94 eV, respectively. The lowest unoccupied molecular orbital energy levels (E LUMO ) of (dfppy)Pt(Tfl-pic) and (C 16 dfppy)Pt(Tfl-pic) were \u22122.23 and \u22122.0 eV based on the equation E LUMO = E HUMO + E g , respectively, in which energy band gap (E g ) was estimated from the UV\u2013vis absorption threshold [32] . Compared to (dfppy)Pt(pic) complex, (dfppy)Pt(Tfl-pic) present an increased energy gap due to introduction of trialkylfluorene group into picolinic acid. Moreover, an additional introduction of alkyl to the cyclometalated ligand further results in energy gap decrease of (C 16 dfppy)Pt(Tfl-pic). 2.5 Electroluminescent property To investigate electroluminescence (EL) properties of these platinum (II) complexes, the single-layer devices were fabricated with a structure of ITO/PEDOT : PSS (50 nm)/dopant + PVK\u2013PBD (45 nm)/Ba (4 nm)/Al (150 nm), in which ITO is used as the anode, PEDOT:PSS is used as a hole-injection layer and Ba/Al is employed as a cathode. The emitting layer is consist of the dopant of platinum (II) complexes and host matrix of PVK-PBD blend, in which doping weight concentration of (dfppy)Pt(Tfl-pic) and (C 16 dfppy)Pt(Tfl-pic) is 10 wt.%, respectively, PBD weight ratio is 30% in the PVK\u2013PBD blend. The EL spectra of the (dfppy)Pt(Tfl-pic) and (C 16 dfppy)Pt(Tfl-pic)-doped PVK\u2013PBD devices at different applied voltage are shown in Fig. 3 . EL spectrum of the (dfppy)Pt(Tfl-pic)-doped device covers whole visible range from 400 to 700 nm ( Fig. 3 a). Two emission peaks at about 590 nm and 418 nm are observed. Compared to PL spectrum of the (dfppy)Pt(Tfl-pic)-based neat film, the high-energy emission is attributed to itself blue emission and the low-energy emission is assigned to its excimer\u2019s emission. With increasing applied voltage, the low-energy emission intensity become stronger and the high-energy emission intensity turn weaker. Their CIE 1931 chromaticity diagram is shown in Figure S2 . While the driving voltage increases from 7 V to 13 V, CIE coordinates of the (dfppy)Pt(Tfl-pic)-doped device vary from (0.27, 0.22) to (0.39, 0.41), which locates in white area. At 10 V, this (dfppy)Pt(Tfl-pic)-doped device displayed bright white light with a CIE coordinate of (0.33, 0.33). The luminance was 650 cd m \u22122 and current efficiency 0.40 cd A \u22121 were obtained in this situation. As far as we know, this is the purest white emission ever reported for platinum (II) complex-doped single-layer PLEDs. However, (C 16 dfppy)Pt(Tfl-pic)-doped device only presented red emission at the different applied voltages in the same device configuration ( Fig. 3 b). The CIE coordinates of the (C 16 dfppy)Pt(Tfl-pic)-doped device have a minor change around (0.40, 0.41) with increased bias from 7 V to 13 V. This implies that a hexadecyl group attached into 5-positon of 2-(2,4-difluorophenyl)pyridine plays an positive role in facilitating the excimer\u2019s formation for its trialkylfluorene-based platinum (II) complexes under electric-excition. In order to explain why the trifluorene-based platinum (II) complexes-doped PLEDs exhibit different EL spectra, we measured the surface morphologies of (dfppy)Pt(Tfl-pic) and (C 16 dfppy)Pt(Tfl-pic) in PVK\u2013PBD film by atomic force microscopy (AFM) as shown in Fig. 4 , respectively. The (dfppy)Pt(Tfl-pic)-doped film displayed a significantly decreased roughness with R a = 1.79 nm (a) while the (C 16 dfppy)Pt(Tfl-pic)-doped film exhibited a roughness with R a = 46.0 nm (b). It indicates that (dfppy)Pt(Tfl-pic) has a better dispersibility than (C 16 dfppy)Pt(Tfl-pic). It may be attributed to that the hook junction effect of this flexible hexadecyl chain can make easily the (C 16 dfppy)Pt(Tfl-pic) molecules aggregation in the host matrix. 3 Conclusion In summary, two alkyl trifluorene-based cyclometalated platinum (II) complexes were obtained. The alkyl-trifluorene group in ancillary ligand and hexadecyl chain in cyclometalated ligand present significantly influence on optophysical and EL properties of its cyclometalated platinum (II) complexes. The device using (dfppy)Pt(Tfl-pic) as dopant presented a white emission with CIE coordinate of (0.33, 0.33) at 10 V, but the other device using (C 16 dfppy)Pt(Tfl-pic) as dopant displayed a red emission with the same single layer device configuration. This work provide an improved approach to control formation excimers of platinum (II) complex by tuning molecular structure with alkyl-trifluorene group in ancillary ligand and long alkyl chain in cyclometalated ligand. The pure white PLEDs can be obtained using this kind of platinum (II) complex as dopant. 4 Experimental All solvents were carefully dried and distilled prior to use. Commercially available reagents were used without further purification unless otherwise stated. Tfl-picH was prepared according to the reported process [26] . All reactions were performed under nitrogen atmosphere and were monitored by thin-layer chromatography (TLC). Flash column chromatography and preparative TLC were carried out using silica gel from Merck (200\u2013300 mesh). All 1 H NMR spectra were acquired at a Bruker Dex-400NMR instrument using CDCl 3 as a solvent. Elemental analysis was performed on a Harrios elemental analysis instrument. The UV absorption and photoluminescence spectra were measured with a Varian Cray50 and Perkin-Elmer LS50B Luminescence Spectrometer, respectively. EL spectra were recorded with an Insta-Spec IV CCD system (Oriel). Luminance was measured with a Si photodiode and calibrated by using a PR-705 spectrascan spectrophotometer (Photo Research). 4.1 Synthesis of (dfppy)Pt(Tfl-pic) To a mixture of K 2 PtCl 4 (0.3 g, 0.84 mmol) and water (5 mL) was added 2,4-difluoropyphenylpyridine (0.4 g, 2.1 mmol) and 2-ethoxyethanol (15 mL). The mixture was stirred vigorously under inert gas atmosphere for 20 h. After cooled, the colored precipitate was filtered off, washed with water and hexane, respectively. A red solid of dimmer of [(dfppy)PtCl] 2 was obtained (0.42 g, 78.0%). Then a mixture of the dimmer (0.2 g, 0.24 mmol), compound Tfl-picH (0.75 g, 0.60 mmol) and sodium carbonate (90 mg, 0.85 mmol) in 2-ethoxyethanol (15 mL) at about 80\u201390\u00b0Cwas stirred vigorously under inert gas atmosphere for 24 h. After cooling to room temperature, the mixture was extracted with DCM and the resulting organic layer was dried over anhydrous magnesium sulfate and distilled to gain black fused liquid. This crude product was purified by a dry flash silica gel column using DCM as eluent to gain the goal product (0.28 g, 53.0%) as a brown red solid. 1 H NMR (CDCl 3 , 400 MHz), \u03b4 (ppm): 9.19\u20139.20 (1H, d, J = 5.2), 7.82\u20137.64 (16H, m), 7.37\u20137.33 (9H, m), 7.12\u20137.10 (1H, t), 6.90\u20136.85 (1H, t), 6.47\u20136.42 (1H, t), 4.10\u20134.06 (2H, t), 2.07\u20132.03 (12H, m), 1.26\u20131.01 (56H, m), 0.81\u20130.71 (27H, m). Anal. Calcd for C 102 H 126 F 2 N 2 O 3 Pt: C 73.75, H 7.65, N 1.69. Found: C 73.48, H 7.60, N 1.73%. 4.2 Synthesis of (C 16 dfppy)Pt(Tfl-pic) It was prepared according to the synthetic procedure of (dfppy)Pt(Tfl-pic). A brown red solid was obtained with a yield of 36.0%.\u03b4 (ppm): 9.98 (1H, s), 7.82\u20137.63 (16H, m), 7.38\u20137.32 (9H, m), 6.89\u20136.85 (1H, t), 6.45\u20136.40 (1H, t), 4.09\u20134.04 (2H, t), 2.64\u20132.62 (2H, t), 2.08\u20132.03 (12H, m), 1.25\u20131.07 (84H, m), 0.81\u20130.78 (30H, m). Anal. Calcd for C 118 H 158 F 2 N 2 O 3 Pt: C 75.16, H 8.45, N 1.49. Found: C 75.08, H 8.53, N 1.55%. Acknowledgements Financial support from The National Natural Science Foundation of China ( 20772101 and 20872124 ), The Science Foundation of Hunan Province ( 2009FJ2002 and 2007FJ3017 ) and The Postgraduate Science Foundation for Innovation in Hunan Province ( S2008 yjscx09 ). Appendix A Supplementary data Supplementary data associated with this article can be found, in the online version, at doi:10.1016/j.orgel.2010.09.012 . Appendix A Supplementary data Supplementary Figure 1 Supplementary Figure 2 Supplementary Figure 3 References [1] Z.J. Zhao B. Xu Z.F. Yang H.Y. Wang X.M. Wang P. Lu W.J. Tian J. Phys. Chem. C 112 2008 8511 [2] K.T. Kamtekar A.P. Monkman M.R. Bryce Adv. Mater. 22 2010 572 [3] Y. Liu M. Nishiura Y. Wang Z.M. Hou J. Am. Chem. Soc. 128 2006 5592 [4] Z.J. Zhao Y.X. Zhao P. Lu W.J. Tian J. Phys. Chem. C 111 2007 6883 [5] M. Mazzeo V. Vitale F. DellaSala M. Anni G. 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Lai M.C.W. Chan T.C. Cheung S.M. Peng C.M. Che Inorg. Chem. 38 1999 4046 [25] P.I. Kvam M.V. Puzyk K.P. Balashev J. Songstad Acta Chem. Scand. 49 1995 335 [26] Y.F. Wang H. Tang Y. Liu C.X. Jiang Z.Y. Hu M.X. Zhu L. Wang W.G. Zhu Y. Cao Tetrahedron 66 2010 1483 [27] S. Lamansky P. Djurovich D. Murphy F. Abdel-Razzaq H.E. Lee C. Adachi P.E. Burrows S.R. Forrest M.E. Thompson J. Am. Chem. Soc. 123 2001 4304 [28] X. Chen J.L. Liao Y. Liang M.O. Ahmed H.E. Tseng S.A. Chen J. Am. Chem. Soc. 125 2003 636 [29] F. Lafolet S. Welter Z. Popovi\u0107 L. De Cola J. Mater. Chem. 15 2005 2820 [30] Q. Peng J. Xu M.J. Li W.X. Zheng Macromolecules 42 2009 5478 [31] V.N. Kozhevnikov B. Donnio D.W. Bruce Angew. Chem., Int. Ed. 47 2008 6286 [32] Z.J. Si J. Li B. Li Z.R. Hong S.Y. Liu W.L. Li J. Phys. Chem. C 112 2008 3920",
        "keywords": [
            "electrophosphorescence",
            "excimers",
            "platinum (ii) complex",
            "synthesis",
            "white polymer light-emitting devices",
            "molecular structure",
            "room temperature",
            "thermal stability",
            "quantum efficiency"
        ],
        "authors": [
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Yu Liu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Xiaoshuang Li",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Hongrui Qi",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Lei Wang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Gangtie Lei",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Qiliang Wei",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            },
            {
                "name": "Junbiao Peng",
                "org": "Institute of Polymer Optoelectronic Material and Devices, South China University of Technology, Guangzhou 510640, China"
            },
            {
                "name": "Yong Cao",
                "org": ""
            }
        ],
        "venue": "Organic Electronics",
        "year": 2010
    },
    "EGBwFgZJ": {
        "id": "EGBwFgZJ",
        "title": "Synthesis of bipolar-transporting materials containing carbazole and aryl oxadiazole groups bridged with 1,2-ethylene and their optoelectronic properties",
        "abstract": "Three bipolar-transporting materials containing carbazole and aryl oxadiazole groups bridged with 1,2-ethylene were synthesized and characterized by 1H NMR, 13C NMR and elemental analysis. Their UV-Vis absorption and photoluminescent properties, as well as their electrochemical properties and thermal stability were also studied. The results show that this class of bipolar-transporting materials displayed UV-Vis absorption and photoluminescent properties of both carbazole and aryl oxadiazole groups, and their thermal decomposing temperatures are over 340\u00b0C. Compared with those bipolar-transporting materials containing carbazole and aryl oxadiazole groups connected with conjugated groups, these bipolar-transporting materials here presented high HOMO and LUMO energy levels and thermal stability.",
        "keywords": [
            "Bipolar-transporting material",
            "Carbazole",
            "Optoelectronic property",
            "Oxadiazole",
            "Synthesis"
        ],
        "authors": [
            {
                "name": "Jian Gao",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yu Liu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Hua Tan",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Liang Li",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yunbo Cao",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Aihui Liang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "Acta Chimica Sinica",
        "year": 2010
    },
    "xYrxup5W": {
        "id": "xYrxup5W",
        "title": "Synthesis and optoelectronic characterization of a monochromic red-emitting europium(III) complex containing triphenylamine-functionalized phenanthroline",
        "abstract": "A triphenylamine-functionalized ternary europium(III) complex of Eu(DBM)3(DTPA-Phen), in which DTPA-Phen is 3,8-bis[4-(diphenylamino) phenyl]-1,10-phenanthroline and DBM is dibenzoylmethanato, was designed, synthesized and characterized. This complex emits the characteristic red emission of trivalent europium ion due to the 5D0 \u2192 7Fj (j = 0-4) transitions under photoexcitation and exhibits high thermal stability (432 \u00b0C). Using this complex as a guest and a blend of poly(9,9-dioctylfluorene) (PFO) along with 2-(tert-butylphenyl)-5- biphenylyl-1,3,4-oxadiazole (PBD) as a host matrix yielded the double-layer polymer light-emitting devices (PLEDs) with high performance. The narrow-bandwidth red emission that peaked at 612 nm with a full width at half-maximum of 10 nm was observed in these devices at the dopant concentrations from 1 to 8 wt %. The highest external quantum efficiency of 1.8% photons per electron at a current density of 1.2 mA/cm2, with a maximum brightness of 1333 cd/m2 at 173.2 mA/cm2, was achieved from the device at 1 wt % dopant concentration. The results indicate that an introduction of triphenylamine groups into phenanthroline ligand can improve the performance of its Eu-organometallic compound-doped PLEDs. \u00a9 2011 American Chemical Society.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Yu Liu,",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yafei Wang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Haipeng Guo",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Chun Li",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            },
            {
                "name": "Junbiao Peng",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yong Cao",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            }
        ],
        "venue": "Journal of Physical Chemistry C",
        "year": 2011
    },
    "Z0ikk9ze": {
        "id": "Z0ikk9ze",
        "title": "Synthesis, optophysical and electrochemical properties of bipolar-transporting europium(III) complexes with carbazole and oxadiazole units",
        "abstract": "A series of bipolar-transporting europium(III) complexes containing carbazole and oxadiazole units were synthesized and characterized. Two intense UV absorption bands at around 286 nm and 352 nm, and sharply red emissions peaked at 614 nm were observed for these europium complexes in dichloromethane. Importantly, the bipolar-transporting europium(III) complexes exhibited higher thermal stability, more intense UV absorption at 286 nm and twofold increased photoluminescent quantum yield compared to the reported red chromophore of tri(dibenzoylmethane) (1,10-phenanthroline) europium(III). Graphical abstract Keywords Europium(III) complexes Synthesis Optophysical properties Bipolar-transporting Carbazole 1,3,4-Oxadiazole 1 Introduction Europium complexes have attracted a great deal of attention in recent decades because of their highly monochromatic red emission from f-orbit electron transition of europium(III) ion and 100% theoretical emission quantum efficiency resulting from both singlet and triplet excitonic emission in organic and polymeric light-emitting devices (OLEDs and PLEDs). 1\u20136 The best europium complex-doped OLED was developed by Kido group, which consisted of tri(dibenzoylmethane) (4,7-biphenyl-1,10-phenanthroline) europium(\u0406\u0406\u0406) dopant and presented an external quantum efficiency (EQE) as high as 7.5% at 0.02 mA/cm 2 with corresponding luminous efficiency of 10 lm/W, as well as gave the maximum brightness of 2797 cd/m 2 . 7 The high-efficiency europium complex-doped PLEDs with an EQE of about 1.0% were demonstrated by McGehee and our groups, respectively. 8,9 These performances of the europium complex-doped devices have not met practical requirement yet. Low EQE and brightness for the europium complex-doped devices were mainly attributed to the poor carrier-transporting ability of europium complexes. 10 Therefore, two main approaches have been developed to improve properties of the europium complex-doped devices. The first approach is doping europium complexes into polymers or small molecular compounds with high hole and/or electron mobility. The second approach is grafting hole- or electron-transporting units on anionic or ancillary ligands. 11\u201314 The grafted hole- and electron-transporting groups (i.e., carrier-transporting groups) mainly contain carbazole, 11\u201313 triphenylamine, 14 and oxadiazole groups. 15,16 Most of europium(III) complexes were tuned by grafting one of two carrier-transporting units in the same ligand. Recently, the first example of modification of europium complex has been reported by Zhang group, in which both hole- and electron-transporting units were, respectively, attached on diketone and phenanthroline. 17 This europium(III) complex involving both hole- and electron-transporting functional groups exhibited an significantly improved device performance with a high brightness of 1845 cd/m 2 and current efficiency of 2.62 cd/A, as well as a low turn-on voltage of 5.5 V. It shows that incorporating both hole- and electron-transporting units into europium complexes is available for improving electroluminescent properties of europium complexes. A promising europium complex used as a red-emitting electroluminescent material should have excellent optophysical and electrochemical properties at least. In order to further study the influence of bipolar-transporting units on these properties, we designed and synthesized another class of novel bipolar-transporting europium complexes by incorporating both hole-transporting carbazole and electron-transporting oxadiazole units into phenanthroline ligand. The structure of europium(III) complexes and their synthetic route are shown in Scheme 1 . As dibenzoylmethane (HDBM) has relatively high PL efficiency and the bipolar-transporting units have been confirmed to have an ability to improve optoelectronic property in OLEDs, 18 this class of europium(III) complexes is expected to exhibit improved optophysical properties. In research on thermal stability, photophysical, and electrochemical properties of these europium complexes, we found that this kind of europium complexes with both carbazole and oxadiazole units presented higher thermal stability, more intense UV absorption at high-energy area and higher emission quantum efficiency compared to the reported tri(dibenzoylmethane) (1,10-phenanthroline) europium(III) [Eu(DBM) 3 Phen]. 2 Experimental 2.1 General Carbazole, 1,6-dibromohexane, dibenzoylmethane (HDBM), tetrahydrofuran (THF), N \u2032 N -dimethylformamide (DMF), dichloromethane (DCM), ethanol, Eu 2 O 3 (99.5%), K 2 CO 3 and KOH were analytic reagents and purchased from some reagent plants in China. 4-(5-Aryl-1,3,4-oxadiazol-2-yl)phenol derivatives were prepared according to previous report. 19,20 5-Amino-1,10-phenanthroline was prepared according to the literature procedure. 21 All other reagents were used from commercial sources, unless otherwise stated. All 1 H NMR spectra were acquired at a Bruker Dex-400NMR instrument using CDCl 3 as solvent. Elemental analysis was carried out on a Heraus CHN-Rapid elemental analyzer. Thermogravimetric analysis (TGA) was performed under a nitrogen atmosphere at a heating rate of 20 \u00b0C/min using a Perkin\u2013Elmer TGA-7 thermal analyzer. The FT-IR spectra were obtained on a Perkin\u2013Elmer spectrum one Fourier transform infrared spectrometer (KBr pellet). Ultraviolet-visible (UV\u2013vis) spectra were measured with a Lambda 25 spectrophotometer. Photoluminescence spectra were conducted on a Perkin\u2013Elmer LS55 luminescence spectrometer with a xenon lamp as a light source. Cyclic voltammetry was carried out on a CHI660A electrochemical work station in a solution of tetrabutylammonium hexafluorophosphate (Bu 4 NPF 6 ) (0.1 M) and acetonitrile at a scan rate of 50 mV/s and room temperature under nitrogen flow protection. These europium complexes were dissolved in the above solution (1 mg cm \u22123 ). A platinum electrode was used as the working electrode. A platinum wire was used as the counter electrode and a calomel electrode was used as the reference electrode. Ferrocene was employed as the reference of redox system. 2.2 Synthesis of 9-(6-bromohexyl)carbazole ( 1 ) 50 mL of 50% KOH aqueous solution was added to a solution of 12.0 g (41.1 mmol) carbazole, 9.6 mL (61.5 mmol) 1,6-dibromohexane, a catalytic amount of tetrabutylammonium bromide, and 50 mL toluene under stirring in a 250 mL three-necked flask and was refluxed for 24 h. The mixture was then evaporated to remove the solvent under vacuum. The residue was extracted with DCM (3\u00d720 mL). The organic layer was washed with water, dried over anhydrous MgSO 4 , and then filtered. The filtrate was evaporated and the residue was purified by silica gel column chromatography using hexanes/DCM (v/v=4: 1) as eluent to provide 9.2 g white solid with a yield of 66.8%. Mp: 70\u201372 \u00b0C. 1 H NMR (400 MHz, CDCl 3 ): \u03b4 ppm 8.09\u20138.11 (d, J =8.4 Hz, 2H), 7.39\u20137.48 (m, 4H), 7.21\u20137.25 (t, 2H), 4.30\u20134.33 (t, 2H), 3.34\u20133.37 (t, 2H), 1.79\u20131.92 (m, 4H), 1.44\u20131.53 (m, 4H). 2.3 Synthesis of 9-(6-(4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenoxy)hexyl)-9 H -carbazole (HPhOXD6Cz) 9-(6-Bromohexyl)carbazole 3.4 g (8.0 mmol) was added to a mixture of 2.4 g (10.0 mmol) 2-(4-hydroxyphenyl)-5-phenyl-1,3,4-oxadiazol (HPhOXDOH), 4.4 g (30.0 mmol) dispersing K 2 CO 3 , 35.0 mL DMF and 0.1 g KI under stirring for 30 min at room temperature. The mixture was refluxed for 24 h under nitrogen atmosphere and allowed to cool to room temperature. Then the reaction mixture was subsequently poured into ice water (100 mL) and extracted with DCM (3\u00d730 mL). The organic layer was washed with water, dried over anhydrous MgSO 4 , and then filtered. The filtrate was evaporated and the residue was purified by recrystallization using THF and ethanol (v/v=1: 2) as solvent to provide 1.7 g pale yellow solid with a yield of 50.8%. Mp: 120\u2013122 \u00b0C. 1 H NMR (400 MHz, CDCl 3 ): \u03b4 ppm 8.14\u20138.10 (m, 4H), 8.07\u20138.04 (d, J =9.2 Hz, 2H), 7.54\u20137.41 (m, 7H), 7.22\u20137.24 (d, J =8.4 Hz, 2H), 6.98\u20136.96 (d, J =8.4 Hz 2H), 4.36\u20134.33 (t, 2H), 4.00\u20133.96 (t, 2H), 1.97\u20131.72 (m, 4H), 1.53\u20131.47 (m, 4H). 2.4 Synthesis of 9-(6-(4-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)phenoxy)hexyl)-9 H -carbazole(FPhOXD6Cz) FPhOXD6Cz was synthesized according to the method described in Section 2.3 . A pale yellow solid was obtained with a yield of 56.8%. Mp: 125\u2013126 \u00b0C. 1 H NMR (400 MHz, CDCl 3 ): \u03b4 ppm 8.13\u20138.10 (m, 4H), 8.05\u20138.03 (d, J =8.6 Hz, 2H), 7.47\u20137.43 (m, 4H), 7.25\u20137.22 (m, 4H), 6.98\u20136.96 (d, J =8.4 Hz, 2H), 4.37\u20134.33 (t, 2H), 4.00\u20133.97 (t, 2H), 1.96\u20131.93 (t, 2H), 1.81\u20131.77 (t, 2H), 1.53\u20131.47 (m, 4H). 2.5 Synthesis of 9-(6-(4-(5-p-tolyl-1,3,4-oxadiazol-2-yl)phenoxy)hexyl)-9 H -carbazole (MePhOXD6Cz) MePhOXD6Cz was synthesized according to the method described in Section 2.3 . A pale yellow solid was obtained with a yield of 50.8%. Mp: 122\u2013123 \u00b0C. 1 H NMR (400 MHz, CDCl 3 ): \u03b4 ppm 8.12\u20138.02 (m, 6H), 7.47\u20137.41 (m, 4H), 7.26\u20137.23 (d, J =9.4 Hz, 2H), 7.04\u20136.95 (m, 4H), 4.59\u20134.33 (t, 2H), 4.00\u20133.96 (t, 2H), 2.44 (s, 3H), 1.98\u20131.75 (m, 4H), 1.58\u20131.47 (m, 4H). 2.6 Synthesis of 9-(6-(4-(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)phenoxy)hexyl)-9 H -carbazole (MeOPhOXD6Cz) MeOPhOXD6Cz was synthesized according to the method described in Section 2.3 . A white solid was obtained with a yield of 49.2%. Mp: 123\u2013125 \u00b0C. 1 H NMR (400 MHz, CDCl 3 ): \u03b4 ppm 8.12\u20138.02 (m, 6H), 7.47\u20137.41 (m, 4H), 7.26\u20137.23 (d, J =9.4 Hz, 2H), 7.04\u20136.95 (m, 4H), 4.36\u20134.33 (t, 2H), 4.00\u20133.96 (t, 2H), 3.89 (s, 3H), 1.98\u20131.75 (m, 4H), 1.58\u20131.47 (m, 4H). 2.7 Synthesis of 9-(6-(4-(5-(4- tert -butylphenyl)-1,3,4-oxadiazol-2-yl)phenoxy)hexyl)-9 H -carbazole (Bu t PhOXD6Cz) Bu t PhOXD6Cz was synthesized according to the method described in Section 2.3 . A pale yellow solid was obtained with a yield of 54.0%. Mp: 118\u2013119 \u00b0C. 1 H NMR (400 MHz, CDCl 3 ): \u03b4 ppm 8.12\u20138.10 (d, J =8.4 Hz, 2H), 8.05\u20138.03 (m, 4H), 7.55\u20137.53 (d, J =8.4 Hz, 2H), 7.46\u20137.40 (m, 4H), 7.23\u20137.25 (d, J =8.4 Hz, 2H), 6.97\u20136.95 (d, J =8.5 Hz, 2H), 4.36\u20134.33 (t, 2H), 4.00\u20133.96 (t, 2H), 1.98\u20131.75 (m, 4H), 1.58\u20131.48 (m, 4H), 1.37 (s, 9H). 2.8 Synthesis of 9-(6-(4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenoxy)hexyl)-9 H -carbazole-3-car-baldehyde (HPhOXD6Cz-CHO) Phosphorus oxychloride 2.85 mL (30.5 mmol) was added dropwise into a solution of 1.02 mL (45.8 mmol) DMF and 30 mL 1,2-dichloroethane with stirring under ice bath and nitrogen atmosphere. The mixture was stirred for another 1 h at room temperature, and 1.7 g (4.03 mmol) HPhOXD6Cz dissolved in DMF (10 mL) was added into it. Then the reaction temperature was raised to 85 \u00b0C and the mixture was continued to be stirred for 24 h. The resulting mixture was permitted to cool to room temperature and poured into ice water (50 mL), then extracted with DCM (3\u00d730 mL). The resulting organic layer was washed with water, dried over anhydrous MgSO 4 , and filtered. The filtrate was evaporated and the residue was purified by silica gel column chromatography using hexanes/ethyl acetate (v/v=3: 1) as eluent to provide 0.94 g yellow solid with a yield of 60.2%. Mp: 100\u2013100.5 \u00b0C. 1 H NMR (400 MHz, CDCl 3 ): \u03b4 ppm 10.11 (s, 1H), 8.63 (s, 1H), 8.19\u20138.02 (m, 6H), 7.55\u20137.47 (m, 6H), 6.99\u20136.97 (d, J =8.8 Hz, 2H), 4.41\u20134.37 (t, 2H), 4.02\u20133.98 (t, 2H), 2.01\u20131.93 (m, 2H), 1.82\u20131.78 (m, 2H), 1.56\u20131.49 (m, 4H). 2.9 Synthesis of 9-(6-(4-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)phenoxy)hexyl)-9 H -carbazole-2-carbaldehyde (FPhOXD6Cz-CHO) FPhOXD6Cz-CHO was synthesized according to the method described in Section 2.8 . A yellow solid was obtained with a yield of 51.2%. Mp: 98\u201399 \u00b0C. 1 H NMR (400 MHz, CDCl 3 ): \u03b4 ppm 10.11 (s, 1H), 8.64 (s, 1H), 8.19\u20138.02 (m, 6H), 7.55\u20137.47 (m, 6H), 6.99\u20136.97 (d, J =8.8 Hz, 2H), 4.42\u20134.38 (t, 2H), 4.02\u20133.99 (t, 2H), 2.00\u20131.79 (m, 4H), 1.56\u20131.49 (m, 4H). 2.10 Synthesis of 9-(6-(4-(5- p -tolyl-1,3,4-oxadiazol-2-yl)phenoxy)hexyl)-9 H -carbazole-2-carbaldehyde (MePhOXD6Cz-CHO) MePhOXD6Cz-CHO was synthesized according to the method described in Section 2.8 . A yellow solid was obtained with a yield of 49.2%. Mp: 99\u2013100 \u00b0C. 1 H NMR (400 MHz, CDCl 3 ): \u03b4 ppm 10.11 (s, 1H), 8.63 (s, 1H), 8.19\u20138.01 (m, 6H), 7.57\u20137.47 (m, 3H), 7.34\u20137.33 (d, J =7.9 Hz, 3H), 6.98\u20136.96 (d, J =8.6 Hz, 2H), 4.40\u20134.14 (t, 2H), 4.08\u20133.80 (t, 2H), 2.45 (s, 3H), 2.09\u20131.80 (m, 4H), 1.58\u20131.37 (m, 4H). 2.11 Synthesis of 9-(6-(4-(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)phenoxy)hexyl)-9 H -carbazole-2-carbaldehyde (MeOPhOXD6Cz-CHO) MeOPhOXD6Cz-CHO was synthesized according to the method described in Section 2.7 . A yellow solid was obtained with a yield of 51.2%. Mp: 99\u2013101 \u00b0C. 1 H NMR (400 MHz, CDCl 3 ): \u03b4 ppm 10.11 (s, 1H), 8.64 (s, 1H), 8.19\u20138.02 (m, 6H), 7.55\u20137.47 (m, 4H), 7.06\u20137.04 (d, J =8.6 Hz, 2H), 6.98\u20136.96 (d, J =8.6 Hz, 2H), 4.41\u20134.38 (t, 2H), 4.02\u20133.98 (t, 2H), 3.91 (s, 3H), 2.01\u20131.96 (m, 2H), 1.82\u20131.75 (m, 4H), 1.56\u20131.49 (m, 4H). 2.12 Synthesis of 9-(6-(4-(5-(4- tert -butylphenyl)-1,3,4-oxadiazol-2-yl)phenoxy)hexyl)-9 H -carbazole-2-carbaldehyde (Bu t PhOXD6Cz-CHO) Bu t PhOXD6Cz-CHO was synthesized according to the method described in Section 2.8 . A yellow solid was obtained with a yield of 57.2%. Mp: 97\u201399 \u00b0C. 1 H NMR (400 MHz, CDCl 3 ): \u03b4 ppm 10.10 (s, 1H), 8.62 (s, 1H), 8.18\u20138.00 (m, 6H), 7.55\u20137.46 (m, 6H), 6.97\u20136.95 (d, J =8.7 Hz, 2H), 4.40\u20134.36 (t, 2H), 4.00\u20133.97 (t, 2H), 2.04\u20131.75 (m, 4H), 1.56\u20131.49 (m, 4H), 1.37 (s, 9H). 2.13 Synthesis of N -((9-((4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenoxy)methyl)-9 H -carbazol-3-yl)methylene)-1,10-phenanthrolin-5-amine (HPhOXD6CzPhen) A mixture of 0.1 g (1.05 mmol) 5-amino-1,10-phenanthroline, 0.5 g (1.2 mmol) HPhOXD6Cz-CHO, 15 mL CHCl 3 , and a catalytic amount of acetic acid was refluxed for 6 h. After evaporated solvent, a yellow solid was formed. The solid crude was collected and washed with methanol, and then was purified by recrystallization from ethanol to provide 0.32 g yellow solid with a yield of 70%. Mp: 81\u201382 \u00b0C. 1 H NMR (400 MHz, CDCl 3 ): \u03b4 ppm 9.24\u20139.22 (d, J =8.4 Hz, 1H), 9.13\u20139.12 (d, J =8.4 Hz, 1H), 8.87\u20138.75 (t, 2H), 8.23\u20138.20 (m, 2H), 8.06\u20138.01 (q, 5H), 7.36\u20137.26 (m, 8H), 6.98\u20136.96 (d, J =8.6 Hz, 2H), 4.44\u20134.40 (t, 2H), 4.01\u20133.98 (t, 2H), 1.99\u20131.97 (m, 4H), 1.83\u20131.80 (m, 4H). 2.14 Synthesis of N -((9-((4-(5(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)phenoxy)methyl)-9 H -carbazole-3-yl)methylene)-1,10-phenanthrolin-5-amine (FPhOXD6CzPhen) FPhOXD6CzPhen was synthesized according to the method described in Section 2.13 . A yellow solid was obtained with a yield of 62%. Mp: 82\u201383 \u00b0C. 1 H NMR (400 MHz, CDCl 3 ): \u03b4 ppm 9.24\u20139.23 (d, J =5.4 Hz, 1H), 9.13\u20139.12 (d, J =5.4 Hz, 1H), 8.85\u20138.75 (t, 2H), 8.23\u20138.20 (m, 2H), 8.06\u20138.03 (q, 5H), 7.36\u20137.26 (m, 8H), 6.98\u20136.96 (d, J =8.4 Hz, 2H), 4.44\u20134.41 (t, 2H), 4.02\u20133.99 (t, 2H), 2.06\u20131.98 (d, J =8.6 Hz, 4H), 1.82\u20131.79 (t, 4H). 2.15 Synthesis of N -((9-((4-(5- p -tolyl-1,3,4-oxadiazol-2-yl)phenoxy)methyl)-9 H -carbazol-3-yl)methylene)-1,10-phenanthrolin-5-amine (MePhOXD6CzPhen) MePhOXD6CzPhen was synthesized according to the method described in Section 2.12 . A yellow solid was obtained with a yield of 68%. Mp: 82\u201383 \u00b0C. 1 H NMR (400 MHz, CDCl 3 ): \u03b4 ppm 9.24\u20139.23 (d, J =5.4 Hz, 1H), 9.13\u20139.12 (d, J =6.4 Hz, 1H), 8.87\u20138.75 (t, 2H), 8.23\u20138.20 (m, 2H), 8.06\u20138.01 (q, 5H), 7.36\u20137.26 (m, 8H), 6.98\u20136.96 (d, J =8.4 Hz, 2H), 4.44\u20134.40 (t, 2H), 4.01 (s, 2H), 2.45 (s, 3H), 2.00\u20131.70 (m, 8H). 2.16 Synthesis of N -((9-((4-(5(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)phenoxy)methyl)-9 H -carbazol-3-yl)methylene)-1,10-phenanthrolin-5-amine (MeOPhOXD6CzPhen) MeOPhOXD6CzPhen was synthesized according to the method described in Section 2.13 . A yellow solid was obtained with a yield of 50%. Mp: 84\u201385 \u00b0C. 1 H NMR (400 MHz, CDCl 3 ): \u03b4 ppm 9.36\u20139.35 (d, J =5.4 Hz, 1H), 9.13\u20139.12 (d, J =6.4 Hz, 1H), 8.85\u20138.75 (t, 2H), 8.23\u20138.20 (m, 2H), 8.06\u20138.01 (q, 5H), 7.36\u20137.26 (m, 8H), 7.00\u20136.96 (m, 2H), 4.41\u20134.38 (t, 2H), 4.01\u20133.98 (t, 2H), 3.90 (s, 3H), 1.99\u20131.79 (m, 8H). 2.17 Synthesis of N -((9-((4-(5-(4- tert -butylphenyl)-1,3,4-oxadiazol-2-yl)phenoxy)methyl)-9 H -carbazol-3-yl)methylene)-1,10-phenanthrolin-5-amine(Bu t PhOXD6CzPhen) Bu t PhOXD6CzPhen was synthesized according to the method described in Section 2.13 . A yellow solid was obtained with a yield of 74.6%. Mp: 79\u201381 \u00b0C. 1 H NMR (400 MHz, CDCl 3 ): \u03b4 ppm 9.24\u20139.23 (d, J =5.2 Hz, 1H), 9.13\u20139.12 (d, J =5.6 Hz, 1H), 8.87\u20138.75 (t, 2H), 8.23\u20138.20 (m, 2H), 8.06\u20138.01 (q, 5H), 7.36\u20137.26 (m, 8H), 6.98\u20136.96 (d, J =8.4 Hz, 2H), 4.44\u20134.40 (t, 2H), 4.01\u20133.98 (t, 2H), 2.00\u20131.98 (d, J =8.7 Hz, 2H), 1.82\u20131.80 (t, 2H), 1.59\u20131.52 (m, 13H). 2.18 Synthesis of Eu(DBM) 3 (HPhOXD6CzPhen) Eu 2 O 3 0.036 g (0.1 mmol) was dissolved in 1 mL concentrated hydrochloric acid was heated to 70\u201380 \u00b0C to form white EuCl 3 \u00b76H 2 O. This europium chloride was dissolved in ethanol (2.0 mL) for the following procedure. Then, a solution of 0.136 g (0.6 mmol) HDBM in 5 mL ethanol was added to a 25 mL three-necked flask and neutralized to pH=6 with 1 mol/L NaOH aqueous solution under stirring. The above europium chloride solution was then added dropwise into the HDBM solution with stirring. The reaction mixture was stirred for 30 min in room temperature and a solution of 0.150 g (0.2 mmol) HPhOXD6CzPhen in 2 mL THF was added to it. The mixture was then carefully adjusted to pH=6.5\u20137 again and continued to be stirred for 5 h at 50 \u00b0C. The resulting mixture was allowed to cool to room temperature and then added dropwise into 20 mL ethanol. The precipitate was formed and washed with water and ethanol alternately, further was purified by recrystallization with mixing solvents (THF and ethanol, v/v=1: 5) to provide 0.16 g yellow solid with a yield of 60.0%. Mp: 118\u2013119 \u00b0C. FT-IR (KBr, cm \u22121 ) 2923, 1610, 1594, 1549, 1517, 1496, 1477, 1458, 1411, 1308, 1219, 1175, 1067, 1024, 837, 808, 738, 723, 690, 520. Anal. Calcd for EuC 90 H 69 N 6 O 8 (1514.96): C, 71.37; H, 4.59; N, 5.55. Found: C, 70.62; H, 5.04; N, 5.38. 2.19 Synthesis of Eu(DBM) 3 (FPhOXD6CzPhen) Eu(DBM) 3 (FPhOXD6CzPhen) was synthesized according to the method described in Section 2.19 . A yellow solid was obtained with a yield of 58.0%. Mp: 118\u2013120 \u00b0C. FT-IR (KBr, cm \u22121 ) 2924, 1610, 1595, 1550, 1518, 1490, 1477, 1458, 1412, 1384, 1308, 1179, 1069, 841, 744, 737, 518. Anal. Calcd for EuC 90 H 68 FN 6 O 8 (1532.5) C, 70.54; H, 4.47; N, 5.48. Found: C, 69.92; H, 4.34; N, 5.35. 2.20 Synthesis of Eu(DBM) 3 (MePhOXD6CzPhen) Eu(DBM) 3 (MePhOXD6CzPhen) was synthesized according to the method described in Section 2.18 . A yellow solid was obtained with a yield of 65.0%. Mp: 117\u2013117.5 \u00b0C. FT-IR (KBr, cm \u22121 ) 2921, 1610, 1594, 1549, 1517, 1490, 1477, 1457, 1410, 1383, 1308, 1219, 1174, 1067, 814, 737, 722, 519. Anal. Calcd for EuC 91 H 71 N 6 O 8 (1528.54) C, 71.50; H, 4.68; N, 5.50. Found: C, 70.60; H, 4.34; N, 5.41. 2.21 Synthesis of Eu(DBM) 3 (MeOPhOXD6CzPhen) Eu(DBM) 3 (MeOPhOXD6CzPhen) was synthesized according to the method described in Section 2.19 . A yellow solid was obtained with a yield of 71.0%. Mp: 121\u2013123 \u00b0C. FT-IR (KBr, cm \u22121 ) 2937, 1611, 1594, 1549, 1517, 1496, 1477, 1458, 1411, 1384, 1219, 1175, 1067, 1024, 835, 807, 723, 608, 515. Anal. Calcd for EuC 91 H 71 N 6 O 9 (1544.54): C, 70.76; H, 4.63; N, 5.44. Found: C, 73.52; H, 4.71; N, 4.45. 2.22 Synthesis of Eu(DBM) 3 (Bu t PhOXD6CzPhen) Eu(DBM) 3 (Bu t PhOXD6CzPhen) was synthesized according to the method described in Section 2.18 . A yellow solid was obtained with a yield of 57.0%. Mp: 117\u2013118 \u00b0C. FT-IR (KBr, cm \u22121 ) 2930, 1610, 1594, 1549, 1517, 1496, 1477, 1458, 1411, 1384, 1219, 1175, 1067, 1023, 840, 808, 737, 721, 520. Anal. Calcd for EuC 94 H 77 N 6 O 8 (1570.62): C, 71.88; H, 4.94; N, 5.35. Found: C, 71.62; H, 5.34; N, 5.39. 3 Results and discussion 3.1 IR absorption spectrum These bipolar-transporting europium complexes displayed similar IR spectra. The stretching vibration peaks from the C O, C C, and C N double bands were observed at 1594 cm \u22121 , 1517 cm \u22121 , and 1549 cm \u22121 , respectively. It indicates that \u03b2-diketone ligand of HDBM is coordinated to Eu 3+ ion. The skeleton vibration from phenanthroline ring was found at 1538 cm \u22121 . Two C\u2013H bending vibration peaks from phenanthroline ring were displayed at 812 cm \u22121 and 722 cm \u22121 . Another bending vibration peak from Eu\u2013N was also observed at 519 cm \u22121 , which means that the phenanthroline derivatives of RPhOXD6CzPhen are also coordinated to Eu 3+ ion. 22 Therefore, the Eu(DBM) 3 (RPhOXD6CzPhen) complexes were confirmed to be formed by IR data. 3.2 Thermal stability The thermal properties of europium complexes were determined by TGA and the resulting TGA curves are shown in Figure\u00a0S1 . All the bipolar-transporting europium complexes presented an onset degradation temperature ( T d ) for 5% weight loss as high as 300 \u00b0C. For comparison, the T d data are listed in Table 1 . Obviously, these bipolar-transporting europium complexes exhibited better thermal stability than the known Eu(DBM) 3 Phen complex. This implies that incorporating both carbazole and oxadiazole units into the phenanthroline ligand is favorable to enhance the thermal stability of their corresponding europium complexes. Furthermore, the substituent groups in oxadiazole units had a different effect on their thermal stability. Incorporating electron donor substituent group into oxadiazole unit is more available for the enhancement of thermal stability of the europium complexes. 3.3 UV absorption property The normalized UV absorption spectra of europium complexes in DCM are illustrated in Figure\u00a01 . All the bipolar-transporting europium complexes showed an intense high-energy absorption band at about 288 nm and a strong low-energy absorption band at about 352 nm, in which the high-energy absorption band is attributed to \u03c0\u2013\u03c0 \u2217 transition of the bipolar-transporting phenanthroline ancillary ligand and low-energy absorption band is attributed to the singlet-singlet \u03c0\u2013\u03c0 \u2217 transition of the \u03b2-diketone ligand. 23 Compared to Eu(DBM) 3 Phen, the bipolar-transporting europium complexes of Eu(DBM) 3 (RPhOXD6CzPhen) exhibit similar low-energy absorption band, but red-shifted high-energy absorption band. This indicates that these bipolar-transporting units have a significant effect on UV absorption spectra of their europium complexes. 3.4 Photoluminescence property The normalized photoluminescence spectra of europium complexes in DCM and neat film at room temperature are shown in Figure\u00a02 a and Figure\u00a02 b, respectively. All these bipolar-transporting europium complexes displayed an intense sharp low-energy emission peak at 614 nm and a broad weak high-energy emission band between 350 and 550 nm, in which the low-energy emission peak is corresponding to 5 D 0 \u2192 7 F 2 transition of Eu(III) ion, and the high-energy emission band is related to excited states of the phenanthroline derivatives of RPhOXD6CzPhen or to the ligand-to-metal charge transfer (LMCT) transitions resulting from the interaction between the central Eu 3+ ion and the ligand\u2019s first coordination shell. 24,25 While the substituent group is butyl, the Eu(DBM) 3 (Bu t PhOXD6CzPhen) complex exhibited maximum high-energy emission band in DCM and neat film. In contrast, while the substituent group is fluorine, the Eu(DBM) 3 (FPhOXD6CzPhen) complex exhibit the minimum high-energy emission band in DCM and neat film. Compared to Eu(DBM) 3 Phen, Eu(DBM) 3 (FPhOXD6CzPhen) exhibited almost identical emission spectrum in DCM. Therefore, incorporating electron-acceptor substituent group into oxadiazole unit is available for the enhancement of Eu 3+ emission in europium complexes. In order to further understand the emission property of these bipolar-transporting europium complexes, the emission quantum yields were measured using EuCl 3 \u00b76H 2 O ( \u0424 f =0.73% in water) as the standard at room temperature based on the literature. 26 The measured emission quantum yield values of Eu(DBM) 3 (Phen), Eu(DBM) 3 (HPhOXD6CzPhen), Eu(DBM) 3 (FPhOXD6CzPhen), Eu(DBM) 3 (MePhOXD6CzPhen), Eu(DBM) 3 (MeOPhOXD6-CzPhen), and Eu(DBM) 3 (Bu t PhOXD6CzPhen) were 0.78%, 9.9%, 10.5%, 10.1%, 9.5% and 10.3%, respectively. These values are about 12 fold higher emission quantum yields than that of the Eu(DBM) 3 Phen complex. Among these bipolar-transporting europium complexes, Eu(DBM) 3 (FPhOXD6CzPhen) presented highest quantum yield. This indicates incorporating a bipolar-transporting unit into ligand of phenanthroline can facilitate the enhancement of emission quantum yield of its europium complex. Especially, attaching a fluorine substituent group with electron acceptor property into the bipolar-transporting unit is more available to improve emission property. 3.5 Electrochemical property All bipolar-transporting europium complexes presented reversible reduction waves ( E red ) at \u22121.53 to \u22121.94 V versus the saturated calomel electrode (SCE), but their oxidation waves were disappeared. The oxidation potential ( E ox ) had to be estimated based on energy band gap ( E g ) and E red , in which E g was estimated based on the UV\u2013vis absorption edge. Thus, the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) energy levels ( E HOMO and E LUMO ) of europium complexes are calculated according to the empirical relationship formula: E HOMO =\u2212 e ( E ox +4.38) and E LUMO =\u2212e( E red +4.38), proposed by Br\u00e9das group. 27 All the electrochemical data of these europium complexes are listed in Table 1 . The HOMO and LUMO energy levels of the bipolar-transporting europium complexes are \u22125.63 eV to \u22125.91 eV and \u22122.44 eV to \u22122.87 eV, respectively. Compared to the Eu(DBM) 3 Phen complex, these bipolar-transporting complexes exhibited a decrease in the HOMO and LUMO energy levels. The decreased LUMO energy levels are available to facilitate electron injection and transportation from cathode to emitters of europium complexes. Therefore, incorporating both hole-transporting carbazole and electron-transporting oxadiazole unit into ligand can significantly tune electrochemical and carrier-transporting property of its europium complex. 4 Conclusion In summary, a class of bipolar-transporting europium complexes with both carbazole and oxadiazole units were obtained. These bipolar-transporting europium complexes exhibited higher thermal stability and better optophysical properties than Eu(DBM) 3 Phen. A red sharp emission peaked at 614 nm with a significantly increased emission quantum yield was observed for these bipolar-transporting europium complexes in DCM solution. The improved optophysical properties are available for this class of europium complexes to become promising red-emitting electro-luminescent materials. As for research in electroluminescent properties of these bipolar-transporting europium complexes, we are in progress. Acknowledgements This work was supported by the National Natural Science Foundation of China (20772101 and 20872124), the Science Foundation of Hunan Province (2009FJ2002 and 2007FJ3017), Teachers Fund for the Doctoral Program of Higher Education of China ( 200805301013 ), the Postgraduate Science Foundation for Innovation in Hunan Province (S2008 yjscx09 and CX2009B124) and the Hunan Undergraduate Innovation Experiment Plan. Supplementary data Figure\u00a0S1. TG curves of europium complexes recorded in dynamic nitrogen atmosphere (50 mL/min) and heating rate of 20 \u00b0C/min. Supplementary data Figure\u00a0S1. TG curves of europium complexes recorded in dynamic nitrogen atmosphere (50 mL/min) and heating rate of 20 \u00b0C/min. Supplementary data associated with article can be found in online version at doi:10.1016/j.tet.2010.07.003 . References and notes 1 Z. Hong C. Liang R. Li W. Li D. Zhao L.S. Hong S.T. Lee Adv. Mater. 13 2001 1241 2 Q.D. Liang Q.J. Cai K.G. Neoh F.R. Zhu W. 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Pan H. Tian Tetrahedron 62 2006 5035 14 Zhu, Z.W.; Liu, Y.; Luo, C.P.; Hu, Z.Y.; Zhu, M.X. ZhongGuo FaMing ZhuanLi ZL, 2006-100325507. 15 F.S. Liang Q.G. Zhou Y.X. Cheng L.X. Wang D.G. Ma X.B. Jing F.S. Wang Chem. Mater. 15 2003 1935 16 Z. Liu F.S. Wen W.L. Li Thin Solid Films 478 2005 265 17 H.J. Tang H. Tang Z.G. Zhang C.J. Cong K.L. Zhang Synth. Met. 159 2009 72 18 S.L. Lin L.H. Chan R.H. Lee M.Y. Yen W.J. Kuo C.T. Chen R.J. Jeng Adv. Mater. 20 2008 3947 19 Y. Liu G.J. Su K.Q. Xing Q. Gan Y.P. Yang X.Y. Wang W.G. Zhu Nat. Sci. J. Xiangtan Univ. 28 2006 68 (in Chinese) 20 Z.W. Xu Y. Li X.M. Ma X.D. Gao H. Tian Tetrahedron 64 2008 1860 21 J.P. Lecomte A.K.D. Mesmaeker J. Lhomme J. Chem. Soc., Faraday Trans. 89 1993 3261 22 K. Ueno A.E. Martell J. Phys. Chem. 60 1956 1270 23 J.C.G. B\u00fcnzli E. Moret V. Foiret K.J. Schenk W. Mingzhao J. Linpei J. Alloys Compd. 107 1994 207 24 S.S. Braga R.S. Ferreira I.S. Goncalves M. Pillinger L.D. Carlos J. Phys. Chem. 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        "keywords": [
            "1",
            "3",
            "4-oxadiazole",
            "bipolar-transporting",
            "carbazole",
            "europium(iii) complexes",
            "optophysical properties",
            "synthesis",
            "quantum yield",
            "thermal stability"
        ],
        "authors": [
            {
                "name": "Liang Li",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Yu Liu",
                "org": ""
            },
            {
                "name": "Haipeng Guo",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Yunbo Cao",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Aihui Liang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Hongrui Qi",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            }
        ],
        "venue": "Tetrahedron",
        "year": 2010
    },
    "OlGw6N5T": {
        "id": "OlGw6N5T",
        "title": "Polyfluorene derivatives pending iridium complexes: Improved optoelectronic properties by introducing D-A units and altering pendent mode",
        "abstract": "To study influence of the donor(D)-acceptor(A) units and pendent mode of phosphorescent moiety on the opto-electronic properties for its resulting copolymers, two D-A-based polyfluorene derivatives (P1 and P2) pending the red-emitting iridium bi(phenylisoquilonato) (picolinato) [Ir(Piq) 2(pic)] unit and a polyfluorene derivative (P3) only pending Ir(Piq) 2(pic) unit were synthesized and characterized, in which the donor of carbazole, the acceptor of oxadiazole are grafted into the C-9 position of fluorene, the Ir(Piq) 2(pic) unit is pended into either the C-9 position for P1 and P3 or the end for P2 of fluorene by unconjugated linkage, respectively. Their opto-electronic properties were significantly influenced by the D-A units and pendent mode of the Ir(Piq) 2(pic) unit. In the polymer light-emitting devices with a configuration of ITO/PEDOT/polymers/LiF/ Al, the P1 showed best electroluminescent properties than the P2 and P3. The maximum current efficiency of 0.72 cd/A and the highest luminance of 1398 cd/m2 were obtained in the P1-based device, which are 1.3 and 1.5 times higher than those in the P2-based device, respectively. \u00a9 2012 Wiley Periodicals, Inc.",
        "keywords": [
            "2",
            "7-polyfluorene",
            "conjugated polymers",
            "light-emitting diodes (led)",
            "metal-polymer complexes"
        ],
        "authors": [
            {
                "name": "Hua Tan",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "JunTing Yu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Jianhua Chen",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Kaixuan Nie",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Qing Chen",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Ying Huang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Zhiyong Zhang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yafei Wang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yu Liu,",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Gangtie Lei",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "Journal of Polymer Science, Part A: Polymer Chemistry",
        "year": 2012
    },
    "lIm2qoyV": {
        "id": "lIm2qoyV",
        "title": "Synthesis and photovoltaic performances of benzo[1,2-b:4,5-b']dithiophene- alt-2,3-diphenylquinoxaline copolymers pending functional groups in phenyl rings",
        "abstract": "Two donor/acceptor (D/A)-based benzo[1,2-b:4,5-b\u2032]dithiophene-alt-2, 3-biphenyl quinoxaline copolymers of P1 and P2 were synthesized pending different functional groups (thiophene or triphenylamine) in the 4-positions of phenyl rings. Their thermal, photophysical, electrochemical, and photovoltaic properties, as well as morphology of their blending films were investigated. The poly(4,8-bis((2-ethyl-hexyl)oxy)benzo[1,2-b:4,5-b'] dithiophene)-alt-(2,3- bis(4\u2032-bis(N,N-bis(4-(octyloxy) phenylamino)- 1,1\u2032-biphen-4-yl) quinoxaline) (P2) exhibited better photovoltaic performance than poly(4,8-bis((2-ethylhexyl)oxy)benzo[1,2-b:4,5-b'] dithiophene)-alt-(2,3-bis(4- (5-octylthiophen-2-yl)phenyl)quinoxaline) (P1) in the bulk-heterojunction polymer solar cells with a configuration of ITO/PEDOT:PSS/polymers: [6,6]-phenyl-C71-butyric acid methyl ester (PC71BM)/LiF/ Al. A power conversion efficiency of 3.43%, an open-circuit voltage of 0.80 V, and a short-circuit current of 9.20 mA cm-2 were achieved in the P2-based cell under the illumination of AM 1.5, 100 mW cm-2. Importantly, this power conversion efficiency level is 2.29 times higher than that in the P1-based cell. Our work indicated that incorporating triphenylamine pendant in the D/A-based polymers can greatly improved the photovoltaic properties for its resulting polymers. Copyright \u00a9 2012 Wiley Periodicals, Inc.",
        "keywords": [
            "benzo[1",
            "2-b:4",
            "5-b']dithiophene",
            "bulk heterojunction",
            "d-a copolymer",
            "polymer solar cells",
            "quinoxaline"
        ],
        "authors": [
            {
                "name": "Hua Tan",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Xianping Deng",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "JunTing Yu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Jianhua Chen",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Kaixuan Nie",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Ying Huang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yu Liu,",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yafei Wang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "Journal of Polymer Science, Part A: Polymer Chemistry",
        "year": 2013
    },
    "qCjWRz0b": {
        "id": "qCjWRz0b",
        "title": "Green-Yellow Electrophosphorescence from di [2,5-diphenyl-1,3,4-oxadiazole C 2\u2032, N 3] Platinum(II) Doped PVK Devices",
        "abstract": "Employing a blend of poly (N-vinylcarbazole) (PVK) and 5-biphenyl-2-(4- tert-butyl)phenyl-1,3,4-oxadiazole) (PBD) as host matrix and a novel bicyclometalated Pt-complex containing 1,3,4-oxadiazole moiety as guest matrix with 2wt.% doping concentration, we have demonstrated efficient phosphorescence-based polymer lightemitting devices (PLEDs). The devices emitted intense green-yellow electrophosphorescence. No emission from either PVK or PBD was observed for the devices. The electroluminescence spectrum exhibited three primary peaks at 525 nm, 568 nm and 608 nm. A maximum external quantum efficiency of 2.3% ph/el and a luminous efficiency of 3.8 cd/A were achieved at a current density of 3.4 mA/cm 2. The results demonstrate that highly efficient electrophosphorescence can be achieved from platinum complex-based polymer light-emitting devices. \u00a9 2005 Chinese Physical Society and IOP Publishing Ltd.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Jian Liu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Zhu Mei-Xiang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Jiang Chang-Yun",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            },
            {
                "name": "Yu Liu,",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Wu Zhong-Lian",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Li Jian-Ren",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Xing Kong-Qiang",
                "org": "Qiongzhou University(Qiongzhou University),Sanya,China"
            },
            {
                "name": "Yong Cao",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            },
            {
                "name": "Zhu Wei-Guo",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2005
    },
    "VAhDwRZd": {
        "id": "VAhDwRZd",
        "title": "Highly efficient saturated red electrophosphorescence from isoquinoline-based iridium complex containing triphenylamino units in polymer light-emitting devices",
        "abstract": "A new red-emitting isoquinoline-based iridium complex containing triphenylamino units displayed high external quantum efficiency of 10.8% and peak emission wavelength of 637 nm in the devices using PFO-PBD blend as host matrix. Abstract To obtain highly efficient saturated red-emitting polymer light-emitting devices, the opto-physical and electrophosphorescent properties of a novel isoquinoline-based iridium complex containing triphenylamino units were investigated. The devices using this iridium complex as a dopant and a blend of poly(9,9-dioctylfluorene) and 2- tert -butylphenyl-5-biphenyl-1,3,4-oxadiazole as a host matrix displayed bright saturated red emission at 637 nm with Commission Internationale de I\u2019Eclairage coordinate of (0.64, 0.31). The maximum external quantum efficiency of 10.8% photos/electron and current efficiency of 4.6 cd/A at 1.7 mA/cm 2 , and the peak brightness of 5453 cd/m 2 at 228 mA/cm 2 were obtained in the device at 2% dopant concentration. 1 Introduction Cyclometalated complexes with third-row transition metal ions have attracted considerable attention due to their potential applications in phosphorescence-based organic and polymeric light-emitting devices (OLEDs/PLEDs) in recent decade [1\u20135] . Among these complexes, iridium (III) complexes have displayed excellent luminous performance in OLEDs with emission from blue to red because iridium complexes can reap both singlet and triplet excitons during their devices operation. The maximum external quantum efficiency (EQE) of 19% was reported in the iridium complexes-doped OLEDs [2] . However, the iridium complexes-doped PLEDs displayed luminous efficiencies lower than the iridium complexes-doped OLEDs [6\u20139] . As PLEDs can be made by wet-process such as spin-coating and printing technique and have potential applications in large area full-color displays, it is significant to achieve the high-efficiency iridium complexes-doped PLEDs with full-color emissions. Up to now, the red- and blue-emitting iridium complexes have not displayed satisfactory luminous efficiencies in the doped PLEDs yet, while the green-emitting iridium complexes exhibited high luminous efficiencies [6\u20138] . As the luminous efficiencies tend to decrease with increasing emission wavelengths, there is additional difficulty to obtain the high-efficiency red emitters [10] . In order to enhance the luminous performances of the red emitters in the PLEDs, some groups have developed the isoquinoline- [6a,6b] , quinoxaline- [6c] , pyridine- [6d,6e] , pyrizine- [6g] and quinoline- [6h] based iridium complexes. The maximum EQE of 12% and the current efficiency of 11.4 cd/A with a peak emission at 624 nm were recently presented in the PLEDs using the phenylisoquinoline- and phenylquinoline-based iridium complexes as emitters by Jiang and Wu, respectively [6a,6h] . In this Letter, we report our effort to achieved high-efficiency PLEDs with deep red emission. The opto-physical and electrophosphorescent properties of a novel iridium complex containing 4-(isoquinoline-1\u2032)-triphenylamine (tpaiq) and acetylacetone (Hacac) were demonstrated. In the previous research, the iridium complexes with the diphenylamino and dimethylamino units exhibited the suppressed phase segregation and self-quenching process, as well as the enhanced carrier-transporting ability in the doped OLEDs [1b,11] . We suggest that isoquinoline-based iridium complex attaching triphenylamino units can also display improved luminous properties owing to the space effect and carrier-transporting nature of triphenylamino units. As expected, we achieved high-efficiency iridium complex. An EQE of 10.8% with a peak emission at 637 nm and Commission Internationale de I\u2019Eclairage (CIE) coordinates of (0.64, 0.31) were exhibited in the iridium complex-doped device using a blend of poly(9, 9-dioctylfluorene) (PFO) and 2- tert -butyl-phenyl-5-biphenyl-1,3,4-oxadiazole (PBD) as a host matrix. 2 Experimental The Ir(tpaiq) 2 (acac) complex was synthesized according to modified methods [6,12] . The devices were fabricated based on the literature [13] . The doping concentrations of Ir(tpaiq) 2 (acac) were 1%, 2%, 4% and 8%, respectively; and the mass ratio of PBD was 20% in the PFO-PBD blend. PFO with molecular weight of 100 000 and PBD were purchased from American Dye Source Inc. The molecular structure of Ir(tpaiq) 2 (acac) and the device configuration are shown in Fig. 1 . UV\u2013vis absorption spectra were recorded on a PerkinElmer Lambda 25 UV\u2013vis absorption spectrophotometer. Cyclic voltammtry was carried out on a CHI660A electrochemical work station. Oxidative potential was measured by cyclic voltammtry based on the literature [14] . Optical band gap was estimated based on the absorption edge of metal-ligand charge transfer (MLCT). Reductive potential was calculated by the optical band gap and oxidative potential. On the basis of the energy level of ferrocene (4.74 eV under vacuum) as well as the data of the oxidative and reductive potentials, we can estimate the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) energy levels of the complex [15] . Photoluminescence (PL) spectra under excitation of 325 nm line of a He\u2013Cd laser (OmniChrome Co.) and electroluminescence (EL) spectra were recorded with an InstaSpec IV CCD System (Oriel). EQEs were obtained by measuring the total light output in all directions in the integrating sphere. Current\u2013voltage ( I \u2013 V ) data were collected with a computerized Keithley 236 Source Measure Unit. Luminance was measured with a Si photodiode and calibrated by using a PR-705 SpectraScan Spectrophotometer (Photo Research). 3 Results and discussion Fig. 2 shows the UV\u2013vis absorption spectrum of the Ir(tpaiq) 2 (acac) complex in dichloromethane and emission spectrum of the PFO-PBD blend at 298 K. The multiple absorption bands of the iridium complex are displayed in the UV spectral profile. The absorption band around 363 nm is assigned to a typical spin-allowed 1 \u03c0\u2013\u03c0 \u2217 transition of the tpaiq ligand because the corresponding transition was also observed in the free tpaiq-based UV spectral profile. The next lower-lying absorption band in the region of 412\u2013493 nm is derived from the mixing singlet and triplet MLCT transitions and, to a certain extent, the intraligand 3 \u03c0\u2013\u03c0 \u2217 transitions. Three absorption bands from the MLCT transitions are observed, indicating the presence of multiple close lying MLCT states in this complex [1b] . A reasonable overlap between the emission profile of the PFO-PBD blend and the absorption bands of this iridium complex is observed in Fig. 2 , which enable an efficient F\u00f6rster energy transfer from the singlet-excited state of the host to the MLCT states of the iridium complex. Fig. 3 a shows the PL spectra of Ir(tpaiq) 2 (acac) doped into the PFO-PBD blend at different doping ratios under excitation of 325 nm line from a He\u2013Cd laser. The extent of energy transfer from the PFO-PBD blend to the Ir(tpaiq) 2 (acac) dopant is presented in the PL spectral profiles at the dopant concentrations of 1\u20138%. All these PL profiles contain two components: one component peaks around 418 nm, which originates from the exciplex emission of the PFO-PBD blend; another component peaks at 635 nm with a shoulder at 691 nm corresponding to the triplet emission of the Ir(tpaiq) 2 (acac) complex. With increasing dopant concentrations from 1% to 2%, the contribution of PFO-PBD emission decreased very quickly. A further increase in the dopant concentrations from 2% to 8% resulted in few change in the contribution of PFO-PBD emission. Complete quenching of the PFO-PBD emission is not observed even at the dopant concentration of 8%. This implies that energy transfer from the PFO-PBD blend to the Ir(tpaiq) 2 (acac) complex is inefficient under photo-excitation. In contrast, the EL emissions of the Ir(tpaiq) 2 (acac)-doped PFO-PBD devices are completely dominated by the dopant emission at the dopant concentrations of 1\u20138%, as shown in Fig. 3 b. No PFO-PBD emission is exhibited in the EL spectral profiles of the devices. The dramatic difference between the PL spectra and EL spectra indicates that both F\u00f6rster energy transfer from the PFO-PBD blend to Ir(tpaiq) 2 (acac) and direct charge-trapping/recombination on the Ir(tpaiq) 2 (acac) guest are responsible for the observed EL. Fig. 4 shows the current density\u2013voltage\u2013brightness characteristics of the Ir(tpaiq) 2 (acac)-doped PFO-PBD devices at the dopant concentrations of 1\u20138%. The driving voltages increase as the dopant concentrations increase from 1% to 4%. This observation is consistent with the charge-trapping mechanism proposed previously by Liu et al. [16] . Table 1 summarizes the luminous performance of the devices. The device at 2% dopant concentration displayed the best luminous performances with a turn-on voltage of 7.7 V and the maximum brightness of 5453 cd/m 2 at 20.3 V. These luminous performances are comparable with that reported in the Ir(piq)(acac)-doped PLEDs [6a] . Fig. 5 shows the external quantum efficiency-current density characteristics of the Ir(tpaiq) 2 (acac)-doped PFO-PBD devices at the dopant concentrations of 1\u20138%. The maximum EQEs of the devices exhibited strong dependency on the dopant concentrations. The maximum EQEs of the devices increased as the dopant concentrations increased from 1% to 2%. A further increase in the dopant concentrations from 2% to 8% resulted in a decrease in the maximum EQEs, probably as a result of concentration quenching and triplet\u2013triplet annihilation [16,17] . The highest EQE of 10.8% and luminous efficiency of 4.6 cd/A at 1.7 mA/cm 2 were exhibited in the device at 2% dopant concentration. At a higher current density of 100 mA/cm 2 , the device still displayed an EQE of 7.8% and brightness of 3300 cd/m 2 . This implies that the emission quenching of the Ir(tpaiq) 2 (acac) complex was decreased in the devices at high current density. Furthermore, the maximum EQEs displayed minor change as the dopant concentrations increased from 4% to 8%. At the dopant concentration of 8%, the device still maintained a maximum EQE as high as 7.7%. This indicates that the concentration quenching of the Ir(tpaiq) 2 (acac) doapnt was efficiently suppressed. The decreased emission and concentration quenching for the iridium complex in the devices is related to the tuned molecular structure of the iridium complex at high current density. Incorporating non-plane diphenylamine units into the isoquinoline-based iridium complex can benefit suppression of the molecular aggregation of the iridium complex due to the space effect of triphenylamino units, which finally results in the decreased concentration and emission quenching. On the other hand, incorporating triphenylamino units into the iridium complex can also tune the energy levels and emission color of the complex. The oxidative and reductive potentials of the Ir(tpaiq) 2 (acac) complex were measured to be 0.60 V and \u22121.81 V based on the electrochemical and UV absorption data, respectively. According to an empirical formula, the HOMO and LUMO energy levels of this complex were estimated to be \u22125.34 eV and \u22122.93 eV, respectively [15] . Compared with (piq) 2 Ir(acac), Ir(tpaiq) 2 (acac) has a lower LUMO energy level by 0.1 eV [18] . This implies that Ir(tpaiq) 2 (acac) has better chance to trap the electrons than (piq) 2 Ir(acac). As the LUMO and HOMO energy levels of PFO are \u22122.1 eV and \u22125.8 eV, respectively [19] , the Ir(tpaiq) 2 (acac) complex can function adequately as a carrier trap in the Ir(tpaiq) 2 (acac)-doped PFO-PBD devices and the trapped carriers can also directly recombine on the iridium complex, which result in efficient EL in the devices. Thus, the isoquinoline-based iridium complex displayed good luminous performance in the PFO-PBD hosted PLEDs. The luminous efficiency of the Ir(tpaiq) 2 (acac)-doped PFO-PBD devices is higher than that of the Ir(piq) 2 (acac)-doped PLEDs using a blend of hyperbranched polyfluorene p-substituted triphenylamine and PBD as a host matrix, but a bit lower than that of the Ir(piq) 2 (acac)-doped PLEDs using a blend of polyhedral oligomeric silsesquinoxane-terminated poly(9,9-dioctylfluorene) and PBD as a host matrix reported by Jiang [6a] . This implies that the host matrix and device configuration have also significant influence on the device performances. Therefore, we should further carry out the optimization of polymeric host and device configuration for the Ir(tpaiq) 2 (acac)-doped PLEDs in order to obtain the better device performances. 4 Conclusions We demonstrated high-efficiency saturated red-emitting PLEDs using an isoquinoline-based iridium (III) complex with triphenylamino units as a dopant and a PFO-PBD blend as a host matrix. The bright electroluminescence emission with a maximum at 637 nm and CIE color coordinates of (0.64, 0.31) was presented in the devices. At the current density of 1.7 mA/cm 2 , the device at 2% dopant concentration displayed a highest EQE of 10.8% and luminous efficiency of 4.6 cd/A. Even at the higher current density of 100 mA/cm 2 , the device still displayed a high EQE of 7.8% and brightness of 3300 cd/m 2 . Acknowledgements The authors are grateful to the National Nature Science Foundation of China (50473046 and 20272014), the Outstanding Youth Foundation of Hunan Province (04JJ1002), the Science Foundation of the Ministry of China (204097) and the Science Foundation of the Department of Hunan Province (06JJ2008) for the financial support to our work. References [1] (a) A. Tsuboyama H. Lwawaki M.J. Furugon J. Am. Chem. Soc. 125 2003 12971 (b) K.R. Justinthomas M. Velusamy J.T. Lin Inorg. Chem. 44 2005 5677 [2] C. Adachi M.A. Baldo M.E. Thompson J. Appl. Phys. 90 2001 5048 [3] S.J. Yeh M.F. Wu C.T. Chen Adv. Mater. 17 2005 285 [4] J. kavitha S.Y. Chang Y. Chi Adv. Funct. Mater. 15 2005 223 [5] Y.H. Niu Y.L. Tung Y. Chi Chem Mater. 17 2005 3532 [6] (a) C.Y. Jiang W. Yang J.B. Peng Adv. Mater. 16 2004 537 (b) B. Lang C.Y. Jiang Z. Chen J. Mater. Chem. 16 2006 1281 (c) F.M. Hwang H.Y. Chen P.S. Chen Inorg. Chem. 44 2005 1344 (d) X. Gong J.C. Ostrowski G.C. Bazan Appl. Phys. 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Tao Adv. Funct. Mater. 15 2005 387 [19] X. Gong D. Moses A.J. Heeger Appl. Phys. Lett. 83 2003 183",
        "keywords": [
            "external quantum efficiency"
        ],
        "authors": [
            {
                "name": "Zhengyong Hu",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Cuiping Luo",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Lei Wang",
                "org": "Institute of Polymer Optoelectronics Materials and Devices, South China University of Technology, Guangzhou 510640, China"
            },
            {
                "name": "Fengliang Huang",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Keming Zhu",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Mei-Xiang Zhu",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Wei-Guo Zhu",
                "org": ""
            },
            {
                "name": "Yong Cao",
                "org": "Institute of Polymer Optoelectronics Materials and Devices, South China University of Technology, Guangzhou 510640, China"
            }
        ],
        "venue": "Chemical Physics Letters",
        "year": 2007
    },
    "OrV41FLw": {
        "id": "OrV41FLw",
        "title": "Single-layer white polymer light-emitting diodes based on an iridium (III) complex containing alkyltrifluorene picolinic acid",
        "abstract": "Improved white light emission from the (dfppy) 2 Ir(Tfl-pic)-doped single-emitting device was obtained from mono-molecular blue emission and its exciplex emission between dopant/host. Highlights \u25ba We have presented two novel blue-emitting cyclometalated iridium (III) complexes. \u25ba We investigated the optophysical properties of the iridium (III) complexes. \u25ba Two different devices using (dfppy) 2 Ir(Tfl-pic) as a single emitter were fabricated. \u25ba Improved white emission was obtained by adjusting the electron injection layer.",
        "keywords": [
            "white polymer light-emitting devices",
            "phosphorescence",
            "fluorene",
            "electron injection",
            "exciplex emission",
            "iridium (iii) complex",
            "light emitting diode"
        ],
        "authors": [
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Yu Liu",
                "org": ""
            },
            {
                "name": "Zhiyong Zhang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Jian Luo",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Danyan Shi",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Gangtie Lei",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            },
            {
                "name": "Yong Cao",
                "org": ""
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2011
    },
    "s3v4F89s": {
        "id": "s3v4F89s",
        "title": "White emission from dinuclear cyclometalated platinum(II) complex in single-emitting layer PLEDs",
        "abstract": "Stable white emissions from the single (dfppy) 2 Pt 2 (dipic)-doped devices were exhibited, which comprise mono-molecular blue emission and its excimers emission.",
        "keywords": [
            "polymer light-emitting devices",
            "dinuclear platinum(ii) complex",
            "electroluminescence",
            "white light",
            "methane"
        ],
        "authors": [
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Xianping Deng",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Yu Liu",
                "org": ""
            },
            {
                "name": "Meijun Ni",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Ming Liu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Xiaoshuang Li",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            },
            {
                "name": "Yong Cao",
                "org": ""
            }
        ],
        "venue": "Tetrahedron",
        "year": 2011
    },
    "c5JQmTUb": {
        "id": "c5JQmTUb",
        "title": "Novel cyclometalated platinum (II) complex containing carrier-transporting groups: Synthesis, luminescence and application in single dopant white PLEDs",
        "abstract": "In order to investigate the influence of carrier-transporting groups on the luminescent properties, especially on excimer/aggregation emission, and to obtain single emissive dopants used in white polymer light-emitting diodes with a single emissive-layer structure, two novel platinum complexes derived from a platinum(II) (2-(4\u2032,6\u2032-difluorophenyl)pyridinato-N,C 2\u2032)(picolinate) unit containing carrier-transporting groups were synthesized and characterized, where a triphenylamino or an oxadiazole-triphenylamino functionalized unit was pending into the picolinate by non-conjugated linkage, respectively. Their optophysical, electrochemical and electroluminescent properties were investigated. Compared to their parent platinum complex, both functionalized platinum complexes exhibited a significantly red-shifted photoluminescent profile in neat film and higher photoluminescent quantum efficiency in dichloromethane at room temperature. Furthermore, the platinum complex with oxadiazole-triphenylamino ambipolar transporting group exhibited better photoluminescent properties and offered potential application as a single dopant in a single emissive-layer-based white polymer light-emitting diode. More stable white light emissions were observed in this platinum complex-doped devices at dopant concentrations of 4-8 wt%. The maximum luminous efficiency of 1.01 cd A-1 and the maximum brightness of 2177 cd m-2 were obtained in the polyfluorene-hosted devices. \u00a9 2012 Elsevier Ltd. All rights reserved.",
        "keywords": [
            "electrophosphorescence",
            "platinum (ii) complex",
            "synthesis",
            "white polymer light-emitting devices"
        ],
        "authors": [
            {
                "name": "Aihui Liang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yanhu Li",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yafei Wang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Fei Huang",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            },
            {
                "name": "Hongbin Wu",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            },
            {
                "name": "Yong Cao",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2013
    },
    "r7gii9dR": {
        "id": "r7gii9dR",
        "title": "Highly-efficiency red-emitting platinum (II) complexes containing 4\u2032-diarylamino-1-phenylisoquinoline ligands in polymer light-emitting diodes: Synthesis, structure, photoelectron and electroluminescence",
        "abstract": "Heteroleptic cyclometalated platinum (II) complexes bearing diarylamino-functionalized 1-phenylisoquinoline derivatives as primary ligand and acetyl acetonate as ancillary ligand were prepared and characterized. Single-crystal X-ray diffraction revealed that platinum (II) (4-(isoquinolin-1-yl)- N , N -diphenylbenzenamine-N,C 2 \u2032) (2,4-pentanedionato- O , O ) displayed square planar molecular geometry with Pt\u00b7\u00b7\u00b7Pt separation of 6.328 and 6.275\u00a0\u00c5. The platinum (II) complexes displayed good thermal and morphological stability, as well as intense ligand-centered fluorescence and \u03c0\u2013\u03c0* phosphorescence at 298\u00a0K, as well as strong phosphorescence at 77\u00a0K in dichloromethane. The double-layer polymer light-emitting diodes using 6a as emitters and a blend of poly(9,9-dioctylfluorene) and 2-(4- tert -butyl)-phenyl-5-biphenyl-1,3,4-oxadiazole as host matrix exhibit best performance with the maximum external quantum efficiency as high as 8.6% at 0.66\u00a0mA\u00a0cm \u20132 .",
        "keywords": [
            "polymer light-emitting devices",
            "phosphorescence",
            "electroluminescence",
            "platinum (ii) complex",
            "photoluminescence",
            "synthesis",
            "x ray diffraction",
            "double layer",
            "light emitting diode",
            "single crystal",
            "external quantum efficiency"
        ],
        "authors": [
            {
                "name": "Zhengyong Hu",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Danyan Shi",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Xiaoshuang Li",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Lei Wang",
                "org": "Institute of Polymer Optoelectronics Materials and Devices, South China University of Technology, Guangzhou 510640, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            },
            {
                "name": "Yong Cao",
                "org": "Institute of Polymer Optoelectronics Materials and Devices, South China University of Technology, Guangzhou 510640, China"
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2010
    },
    "5rHcafPr": {
        "id": "5rHcafPr",
        "title": "Synthesis of bicyclometalated iridium complex containing 1,3,4-oxadiazole-based picolinic acid derivative and its optoelectronic properties in polymer light-emitting devices",
        "abstract": "A picolinic acid derivative bearing an 1,3,4-oxadiazole unit and its bicyclometalated iridium complex (PhOXD) 2 Ir(BuPhOXD-Pic) were synthesized and characterized, in which BuPhOXD-Pic is 5-(4\u2032-(5\u2033-(4- tert -butylphenyl)-1\u2033,3\u2033,4\u2033-oxadiazol-2\u2033-yl) phenyl) picolinic acid and PhOXD is 2,5-diphenyl-1,3,4-oxadiazole. The optoelectronic properties of this iridium complex were studied in the double-layer polymer light-emitting devices using a blend of poly (9,9-dioctylfluorene) and 5-biphenyl-2-(4- tert -butyl) phenyl-1,3,4-oxadiazole as a host matrix. This complex exhibited a maximum luminance efficiency of 7.7 cd/A at 5.6 mA/cm 2 and a peak brightness of 5288 cd/m 2 at 153.7 mA/cm 2 in the devices. Compared to the (PhOXD) 2 Ir(Pic) complex, the (PhOXD) 2 Ir(BuPhOXD-Pic) complex displays better optoelectronic properties in the devices. This study provides a convenient way to improve the optoelectronic properties of iridium complexes by modifying an ancillary ligand of picolinic acid (Pic) with an 1,3,4-oxadiazole unit. Keywords Iridium complex 1,3,4-Oxadiazole Polymer light-emitting device Photoluminescence Electrophosphorescence 1 Introduction Recently, cyclometalated iridium complexes have attracted great scientific and commercial attention because they have strong spin\u2013orbital coupling of heavy-metal ions and can make full use of both singlet and triplet excitons to emit theoretically with a 100% internal quantum efficiency in organic polymer light-emitting devices (PLEDs) [1\u201322] . In all reported cyclometalated iridium complexes, the blue-emitting iridium complexes displayed lower efficiency than the green- and red-emitting ones. In order to achieve higher efficient blue-emitting iridium complexes, some ancillary ligands have been developed [16\u201322] . The reported ancillary ligands contain diketone [16] , picolinic acid [17] , 1,2,4-triazole [18] , tetrazole [19] and tetrakis (1-pyrazolyl) borate [20\u201322] . However, there is few report on the ancillary ligands tuned directly by functional groups. As oxadiazole derivatives are good candidates for electron injection and transportation in organic and polymer light-emitting devices [23] , they have been introduced into cyclometalated ligands to enhance the optoelectronic properties of their iridium complexes [24\u201327] . But the effect of oxadiazole units employed in ancillary ligands on the optoelectronic properties of their heteroleptic iridium complexes have not been made clear yet. In order to investigate this effect, an ancillary ligand of picolinic acid is directly modified by an oxadiazole unit in 4-position of pyridyl ring and its heteroleptic iridium complex is made, as well as the optoelectronic properties of this iridium complex are studied in the polymer light-emitting devices using a blend of poly (9,9-dioctylfluorene) (PFO) and 5-biphenyl-2-(4- tert -butyl)phenyl-1,3,4-oxadiazole (PBD) as a host matrix. This resulting (PhOXD) 2 Ir(BuPhOXD-Pic) complex is iridium (III) di (2,5-diphenyl-1,3,4-oxadiazole-N, C 2 ) [5-(4\u2032-(5\u2033-(4- tert -butylphenyl)-1\u2033,3\u2033,4\u2033-oxadiazol-2\u2033-yl) phenyl) picolinate]. For comparison, the other (PhOXD) 2 Ir(Pic) complex containing an ancillary ligand of picolinic acid (Pic) is also synthesized. The synthetic route of these two iridium complexes is shown in Scheme 1 . 2 Experimental Benzoyl chloride, 4- tert -butylbenzoic acid, 4-bromobenzoic acid, 5-bromo picolinic acid, phosphorus (III) oxychloride and hydrazine hydrate were purchased from some reagent plants in China. 2-Ethoxyethanol and iridium trichloride hydrate were obtained from ARCOS. 2,5-Diphenyl-1,3,4-oxadiazole (PhOXD) and 2-(4-bromophenyl)-5-(4- tert -butylphenyl)-1,3,4-oxadiazole (BuPhOXDPhBr) were synthesized according to the literature procedures [28,29] . All 1 H NMR spectra were acquired at a Bruker Dex-400NMR instrument using CDCl 3 as solvent. Elemental analysis was performed on a Harrios elemental analysis instrument. 2.1 Synthesis of methyl 5-(4\u2032-(5\u2033-(4- tert -butylphenyl)-1\u2033,3\u2033,4\u2033-oxadiazol-2\u2033-yl) phenyl) picolinate n-Butyllithium/hexane (14.5 mL,1.60 M, 23.4 mmol) was added dropwise in a solution of 2-(4-bromophenyl)-5-(4- tert -butylphenyl)-1,3,4-oxadiazole (8.36 g, 23.4 mmol), anhydrous THF (120 mL) at \u221278 \u00b0C under nitrogen atmosphere in a 500 mL three-neck flask for 1 h under stirring and continued to react for 30 min. A solution of ZnCl 2 (3.14 g, 23.4 mmol) and THF (38 mL) was then added into the above mixture at \u221245 \u00b0C. While the reaction temperature rose to room temperature, a solution of methyl 5-bromo-picolinate (5.0 g, 23.4 mmol), Pd(PPh 3 ) 4 (1.2 g, 0.78 mmol) and THF (120 mL) was added dropwise into the mixture and continued to stir for 2 h. The present mixture was distilled under vacuum and the precipitate was formed. The precipitate was collected and washed respectively with THF, anhydrous ethanol and petroleum ether to obtain 2.0 g pale yellow solid with a yield of 20.3%. 1 H NMR (400 MHz, CDCl 3 , TMS) \u03b4 ppm: 9.07 (s, 1H), 8.30 (d, J = 8.14 Hz, 2H), 8.16 (s, 2H), 8.09 (d, J = 6.6 Hz, 2H), 7.82 (d, J = 8.16 Hz, 2H), 7.57 (d, J = 8.20 Hz, 2H), 4.07 (s, 3H), 1.39 (s, 9H). Anal calcd for C 25 H 23 N 3 O 3 : C, 72.62%; H, 5.61%; N, 10.16%. Found: C, 72.26%; H, 5.58%; N, 10.12%. 2.2 Synthesis of 5-(4\u2032-(5\u2033-(4- tert -butylphenyl)-1\u2033,3\u2033,4\u2033-oxadiazol-2\u2033-yl)phenyl) picolinic acid A solution of methyl 5-(4\u2032-(5\u2033-(4- tert -butylphenyl)-1\u2033,3\u2033,4\u2033-oxadiazol-2\u2033-yl) phenyl) picolinate (0.74 g, 1.8 mmol), THF (60 mL), ethanol (95%, 10 mL) and NaOH aqueous solution (40%, 20 mL) was heated to 60 \u00b0C and stirred for 30 min. Then it was allowed to cool to room temperature and stirred for 30 h. The mixture was evaporated to remove the solvent and mixed with 5 mL water, further was acidified to pH 1 with concentrated HCl. The resulting pale yellow precipitate was filtered, then washed respectively with water, ethanol and petroleum ether to obtain 0.71 g white solid with a yield of 98.3%. 1 H NMR (400 MHz, CDCl 3 , TMS) \u03b4 ppm: 8.93 (s, 1H), 8.36 (s, 2H), 8.31 (s, 2H), 8.11 (d, J = 6.88 Hz, 2H), 7.81 (s, 2H), 7.57 (d, J = 7.44 Hz, 2H), 1.39 (s, 9H). Anal calcd for C 24 H 21 N 3 O 3 : C, 72.16%; H, 5.30%; N, 10.52%. Found: C, 71.91%; H, 5.25%; N, 10.46%. 2.3 Synthesis of (PhOXD) 2 Ir(Pic) A mixture of iridium trichloride hydrate (183 mg, 0.52 mmol), 2,5-diphenyl-1,3,4-oxadiazole (351 mg, 1.58 mmol), sodium chloride (100 mg, 1.71 mmol) and 2-ethoxyethanol (30 mL) was refluxed for 24 h under nitrogen atmosphere and then evaporated under vacuum to remove a majority of 2-ethoxyethanol. The residue was allowed to cool to room temperature and formed the precipitate. The precipitate was collected, and then washed respectively with water, ethanol and dichloromethane to afford 300 mg chlorine-bridged iridium dimer (PhOXD) 4 Ir 2 Cl 2 as a yellow powder. The dimer was directly used in the following procedure. A mixture of the (PhOXD) 4 Ir 2 Cl 2 dimer (300 mg, 0.224 mmol), picolinic acid (160 mg, 1.30 mmol), Na 2 CO 3 (512 mg, 4.83 mmol) and 2-ethoxyethanol (20 mL) was refluxed for 21 h under nitrogen atmosphere, then was allowed to cool to room temperature and mixed with 4 mL water to present a yellow precipitate. The precipitate was collected, washed with water and dried, then was purified by chromatography using dichloromethane as eluent to provide 190 mg solid as a yellow powder with a yield of 56.0%. 1 H NMR (400 MHz, CDCl 3 , TMS) \u03b4 ppm: 8.30 (s, 1H), 8.19 (d, J = 7.36 Hz, 2H), 8.00 (d, J = 7.32 Hz, 2H), 7.87 (d, J = 3.8 Hz, 2H), 7.67 (d, J = 7.45 Hz,1H), 7.50 (m, 8H), 6.87 (m, 5H), 6.73 (s, 1H). Anal calcd for C 34 H 22 IrN 5 O 4 : C, 53.96%; H, 2.93%; N, 9.25%. Found: C, 53.52%; H, 2.85%; N, 9.17%. 2.4 Synthesis of (PhOXD) 2 Ir(BuPhOXDPh-Pic) (PhOXD) 2 Ir(BuPhOXDPh-Pic) was prepared according to the synthetic procedure of (PhOXD) 2 Ir(Pic) with a yield of 42.3% as a yellow powder. 1 H NMR (400 MHz, CDCl 3 , TMS) \u03b4 ppm: 8.39 (s, 1H), 8.11 (t, 6H), 8.01 (t, 4H), 7.62 (d, J = 6.88 Hz, 1H), 7.53 (d, J = 8.71 Hz, 12H), 7.0 (d, J = 5.92 Hz, 4H), 6.76 (d, J = 4.88 Hz, 1H), 1.38 (d, J = 4.56 Hz, 9H). Anal calcd for C 52 H 38 IrN 7 O 5 : C, 60.45%; H, 3.71%; N,9.49%. Found: C, 59.75%; H, 3.65%; N,9.40%. 2.5 Device fabrication and characterization The devices using the iridium complexes as dopants and a blend of PFO and PBD as a host matrix were fabricated on a clean ITO glass substrate with a sheet resistance of 15 \u03a9/sq (Nanbo, Shengzhen) based on our previous work [30] . The devices have a configuration of ITO/PEDOT:PSS, 50 nm/PVK, 50 nm/dopants + PFO\u2013PBD, 75 nm/Ba, 4.5 nm/Al, 150 nm. The dopant weight concentrations are 1%, 2%, 4%, and 8%, respectively. The weight concentration of PBD is 30% in the blend of PFO and PBD. Poly(ethylenedioxy thiophene):poly(styrene sulfonic acid) (PEDOT:PSS, Baytron P4083) was purchased from Bayer AG. Other materials of PVK (122,200 Mw, 57,500 Mn), PFO and PBD were purchased from Aldrich and used without further purification. Photoluminescence (PL) spectra under excitation of 325 nm line of a He\u2013Cd laser (OmniChrome Co.) and electroluminescence (EL) spectra were recorded with an Insta-Spec IV CCD system (Oriel). Current efficiency was obtained by measuring the total light output in all directions in an integrating sphere. Current\u2013voltage ( I \u2013 V ) data were collected with a computerized Keithley 236 source measure unit. Luminance was measured with a Si photodiode and calibrated by using a PR-705 Spectrascan spectrophotometer (Photo Research). Cyclic voltammetry was carried out on a CHI660A electrochemical workstation in a solution of tetrabutylammonium hexafluorophosphate (Bu 4 NPF 6 ) (0.1 M) in dichloromethane at a scan rate of 50 mV/s at room temperature under argon protection. The iridium complex was dissolved in the above solution (1 mg/cm 3 ). A platinum electrode was used as the working electrode. A platinum wire was used as the counter electrode, and a calomel electrode was used as the reference electrode. Ferrocene was employed as the reference redox system. 3 Results and discussion Fig. 1 shows PL spectra of the (PhOXD) 2 Ir(BuPhOXD-Pic)- and (PhOXD) 2 Ir(Pic)-doped PFO\u2013PBD films at the dopant concentrations from 1% to 8%, as well as PL spectrum of the neat PFO\u2013PBD blend at 298 K. These two iridium complexes-doped films and the neat PFO\u2013PBD blend exhibit similar spectral profiles. Three main emission peaks at 420 nm, 442 nm and 511 nm are observed. The dopant concentrations exert a minor effect on these PL profiles of the iridium complexes-doped PFO\u2013PBD films. The PL band about 511 nm becomes wider with increasing dopant concentrations, which is related to the enhanced emission of the iridium complexes at about 540 nm. This implies that emissions of the iridium complexes-doped PFO\u2013PBD films are dominated by the PFO\u2013PBD blend. The energy transfer from the PFO\u2013PBD host to the iridium complex is incomplete under photo-excitation in the doped films at the dopant concentrations from 1% to 8%. Fig. 2 shows UV spectra of the neat iridium complexes films and PL spectra of the PFO\u2013PBD blend. A minor spectral overlaps between PL spectrum of the PFO\u2013PBD blend and UV spectra of these two iridium complexes are observed. This further explains why the energy transfer from the PFO\u2013PBD blend to the iridium complex is incomplete under photo-excitation at given dopant concentrations. Fig. 3 shows EL spectra of the (PhOXD) 2 Ir(BuPhOXD-Pic)- and (PhOXD) 2 Ir(Pic)-doped PFO\u2013PBD devices at the dopant concentrations from 1% to 8%. Similar EL spectra are observed in these doped devices, which are different from PL profiles of the iridium complex-doped PFO\u2013PBD films. The maximum EL emission peaks at 544 nm and 547 nm are displayed in the (PhOXD) 2 Ir(Pic)- and (PhOXD) 2 Ir(BuPhOXD-Pic)-doped devices, respectively. The weak emission peaks at 420 nm and 442 nm also appear in these EL spectral profiles and obviously decrease with increasing dopant concentrations. Compared to (PhOXD) 2 Ir(Pic), (PhOXD) 2 Ir(BuPhOXD-Pic) displays a few red-shifted EL emission peak and weaker emission bands under 450 nm. This suggests that EL emissions of these two iridium complexes-doped PFO\u2013PBD devices are almost dominated by the dopants rather than the PFO\u2013PBD host at the dopant concentrations from 1% to 8%. The ancillary ligand and the dopant concentration of the iridium complex have a little influence on the EL profiles in the devices. The dramatic difference between PL and EL spectra was observed in the other iridium complexes-doped PLEDs, which was attributed to the different emission mechanism [1,30] . Here, the energy transfer from the PFO\u2013PBD blend to the iridium complexes and directly charge-trapping recombination on the iridium complexes may be responsible for the observed EL spectra. Fig. 4 shows luminance efficiency\u2013current density characteristics of the iridium complexes-doped PFO\u2013PBD devices at the dopant concentrations from 1% to 8%. When the dopant concentrations increase from 1% to 4%, these devices display enhancing luminance efficiency. In contrast, the devices exhibit decreasing luminance efficiency with increasing dopant concentrations from 4% to 8%. The maximum luminance efficiency of 7.7 cd/A and a peak external quantum efficiency of 4.0% at 5.6 mA/cm 2 were achieved in a 4% (PhOXD) 2 Ir(BuPhOXD-Pic)-doped device, which are higher twice times than those in a 4% (PhOXD) 2 Ir(Pic)-doped device. In order to further compare the effect of ancillary ligand on the optoelectronic properties of its iridium complex, the other device properties of these two iridium complexes-doped PFO\u2013PBD devices were summarized in Table 1 . We find that the (PhOXD) 2 Ir-(BuPhOXD-Pic)-doped devices display lower turn-on voltage as well as higher brightness and luminance efficiency than the (PhOXD) 2 Ir(Pic)-doped devices. This implies that ancillary ligand has an important influence on the electroluminescent properties of its iridium complex in the devices. In order to explain why (PhOXD) 2 Ir(BuPhOXD-Pic) exhibited better EL properties than (PhOXD) 2 Ir(Pic), we used cyclic voltammetry, with ferrocene as the internal standard, to investigate the electrochemical behavior of these two iridium complexes. The electrochemical data are listed in Table 2 . The reductive potential in the table was estimated by the datum of the oxidative potential and the UV absorption spectral datum of the iridium complex referred to our previous work [31] . Compared to the reported lowest unoccupied molecular orbital (LUMO) energy level of \u22122.1 eV and the highest occupied molecular orbital (HOMO) energy levels of \u22125.8 eV for PFO [31] , we discover that (PhOXD) 2 Ir(BuPhOXD-Pic) exhibits better matched energy levels than (PhOXD) 2 Ir(Pic) to these of PFO host. This indicates that BuPhOXD-Pic instead of picolinic acid as an ancillary ligand can tune the electrochemical properties and further improve the EL properties of the iridium complex. Some groups have reported that incorporating an oxadiazole unit into cyclometalated ligand could enhance the optoelectronic properties of its iridium complex due to good electron-transporting effect of the oxadiazole unit [24\u201327] . Therefore, we suggest that the oxadiazole unit attached into an ancillary ligand of picolinic acid should have a potential to tune the electron-transporting properties of its iridium complex and facilitate the optoelectronic properties of the iridium complex. Modifying the traditional ancillary ligands by some functional groups such as oxadiazole units should become a convenient way to achieve high-efficiency iridium complexes. In order to confirm this suggestion, some investigations on the EL properties of this iridium complex in different devices need be carried out. 4 Conclusions The bicyclometalated iridium complex (PhOXD) 2 Ir(BuPhOXD-Pic) containing an 1,3,4-oxadiazole-based picolinic acid derivative was achieved. It has exhibited better optoelectronic properties than (PhOXD) 2 Ir(Pic) in the doped PFO\u2013PBD devices. Incorporating an oxadiazole group into the ancillary ligand of picolinic acid can make its iridium complex display improved electroluminescent properties in PLEDs. Acknowledgments The authors are grateful to the National Nature Science Foundation of China (No. 50473046 and 20772101), the Hunan Provincial Science Foundation (No. 2007FJ3017 and 06JJ2008), and the Science Foundation of the Education Department of Hunan Province (07C764) for their financial support to our work. References [1] C. Jiang W. Yang J. Peng S. Xiao Y. Cao Adv. Mater. 16 2004 537 [2] B. Liang C.Y. Jiang Z. Chen X.J. Zhang H.H. Shi Y. Cao J. Mater. Chem. 16 2006 1281 [3] Y. Byun Y. Lyu R.R. Das O. Kwon T. Lee Y.J. Park Appl. Phys. Lett. 91 2007 211106 [4] C.-L. Ho W.-Y. Wong Z.-Q. Gao C.-H. Chen K.-W. Cheah B. Yao Z. Xie Q. Wang D. Ma L. Wang X.-M. Yu H.-S. Kwok Z. Lin Adv. Funct. 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Yang X.Y. Wang W.G. Zhu Nat. Sci. J. Xiangtan Univ. 28 2006 68 [29] J.Y. Deng Y. Liu Z.Y. Hu M.X. Zhu W.G. Zhu Chin. J. Appl. Chem. 24 2007 1119 [30] Z.Y. Hu C.P. Luo L. Wang F.L. Huang K.M. Zhu Y.F. Wang M.X. Zhu W.G. Zhu Y. Cao Chem. Phys. Lett. 441 2007 277 [31] X.Y. Ma K.M. Zhu L. Wang F.L. Xiang Z.L. Wen M.X. Zhu W.G. Zhu Chin. Phys. Lett. 25 2008 711",
        "keywords": [
            "1",
            "3",
            "4-oxadiazole",
            "electrophosphorescence",
            "iridium complex",
            "photoluminescence",
            "polymer light-emitting device",
            "double layer"
        ],
        "authors": [
            {
                "name": "Fangliang Xiao",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Yu Liu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Zhengyong Hu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Quan Gan",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Lei Wang",
                "org": "Institute of Polymer Optoelectronics Materials and Devices, South China University of Technology, Guangzhou 510640, PR China"
            },
            {
                "name": "Zhonglin Wen",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            }
        ],
        "venue": "Synthetic Metals",
        "year": 2009
    },
    "uvRzgZxs": {
        "id": "uvRzgZxs",
        "title": "Solution-Processed Highly Efficient Bluish-Green Thermally Activated Delayed Fluorescence Emitter Bearing Asymmetric Oxadiazole-Difluoroboron Double Acceptor.",
        "abstract": "Difluoroboron (BF2)-containing dyes have attracted great interests owing to their exceptionally high luminescence efficiency and good electron-withdrawing properties. However, only few reports on difluoroboron-based thermally activated delayed fluores-cence (TADF) have been addressed. In this contribution, a novel BF2-containing TADF molecule of BFOXD, which contains two acceptor fragments of oxadiazole (OXD) and BF2 and one donor unit of 9,9-dimethylacridine, was synthesized and characterized. For comparison, the precursor of OHOXD bearing one acceptor unit was also investigated. Both molecules clearly show TADF characteristics with sky-blue emission in solution and film state. Additionally, OHOXD undergoes excited-state intramolecular proton transfer (ESIPT) coupled intramolecular charge transfer (ICT) processes. Using 9-(4-tert-butylphenyl)-3,6-bis(triphenylsilyl)-9H-carbazole (CzSi) as the host, the organic light-emitting diodes (OLEDs) fabricating via solution process show maximum external quantum efficiency (EQE) of 2.98 and 13.8% for OHOXD- and BFOXD-based devices, respectively. While the bipolar TADF host of 10-(4-((4-(9H-carbazol-9-yl)phenyl)sulfonyl)phenyl)-9,9-dimethyl-9,10-dihydroacridine (CzAcSF) is utilized instead of CzSi, the OHOXD- and BFOXD-based devices exhibit better performances with the maximum EQE of 12.1% and 20.1%, respectively, which renders the most efficient and the bluest emission ever reported for the BF2-based TADF mole-cules. This research demonstrates that introduction of one more acceptor unit into TADF molecule could play a positive effect on the emission efficiency, which opens a new way for design high efficiency TADF molecules.",
        "keywords": "",
        "authors": [
            {
                "name": "Di Zhou",
                "org": "Xiangtan University"
            },
            {
                "name": "Denghui Liu",
                "org": ""
            },
            {
                "name": "Xu Gong",
                "org": "Hubei Key Lab on Organic and Polymeric Optoelectronic Materials, Department of Chemistry, Wuhan University, Wuhan 430072, China"
            },
            {
                "name": "Huili Ma",
                "org": "Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, China"
            },
            {
                "name": "Gaowei Qian",
                "org": ""
            },
            {
                "name": "Shaolong Gong",
                "org": "Hubei Key Lab on Organic and Polymeric Optoelectronic Materials, Department of Chemistry, Wuhan University, Wuhan 430072, China"
            },
            {
                "name": "Guohua Xie",
                "org": "Hubei Key Lab on Organic and Polymeric Optoelectronic Materials, Department of Chemistry, Wuhan University, Wuhan 430072, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            },
            {
                "name": "Yafei Wang",
                "org": "Shanghai University"
            }
        ],
        "venue": "ACS applied materials & interfaces",
        "year": 2019
    },
    "7r77HFcA": {
        "id": "7r77HFcA",
        "title": "Synthesis, opto-physics, and electroluminescence of cyclometalated iridium (III) complex with alkyltrifluorene picolinic acid",
        "abstract": "To improve the opto-physics, electroluminescence, and dispersibility of iridium (III) complexes in polymer light-emitting devices, we synthesized and characterized two red-emitting heteroleptic cyclometalated iridium (III) complexes of (Piq) 2 Ir(Tfl-pic) and (Piq) 2 Ir(Brfl-pic), in which Piq is 1-phenylisoquinoline, Tfl-pic and Brfl-pic are alkyltrifluorene- and dibromoalkylfluorene-containing picolinic acid derivatives bridged with alkoxy chain, respectively. Compared to (Piq) 2 Ir(pic) and (Piq) 2 Ir(Brfl-pic), (Piq) 2 Ir(Tfl-pic) exhibited higher thermal stability, better dispersibility and excellent quantum efficiency. High-efficiency red emission with a maximum current efficiency of 6.28 cdA \u22121 and a maximum EL peak at 608 nm was obtained in the (Piq) 2 Ir(Tfl-pic)-doped devices using a blend of poly(9,9-dioctylfluorene) and 2-(4-biphenyl)-5-(4- tert -butylphenyl)-1,3,4-oxadiazole as a host matrix. Graphical abstract Keywords OLEDs/PLEDs Fluorene Iridium (III) Synthesis 1 Introduction Third-row transition-metal complexes are well-known for their ability to achieve high-efficiency phosphorescence at room temperature. 1,2 In theory, this kind of cyclometalated complexes has 100% internal quantum efficiency, because they can effectively harvest both singlet and triplet excitons. 3 As a result, Ru II -, Os II -, Ir III -, and Pt II - based cyclometalated complexes have been significantly developed and exhibited wide application in organic/polymer light-emitting devices (OLEDs/PLEDs). 4\u20137 In these reported transition-metal complexes, iridium (III) complexes displayed best electro- phosphorescence with an external quantum efficiency as high as 27% in OLEDs and are considered to be a class of promising electrophosphorescent materials due to their non-planar configuration and short phosphorescent lifetime. 8\u201313 However, there is a crucial issue of phase separation between iridium (III) complexes and host materials to influence the doped device performance. In order to overcome this issue, we once incorporated a bulky tert -butyl group into a cyclometalated ligand of 2-phenylpyridine and obtained a green-emitting heteroleptic iridium (III) complex with improved dispersibility and high-efficiency emission in PLEDs. 14 Some groups reported a series of high-efficiency iridium (III) complexes by introducing other bulky, rigid comphor-like alky-fluorene and dentritic architecture into cyclometalated ligands to effectively suppress the aggregation effect and improve dispersibility. Y Cao et\u00a0al. reported the fluorenyl-substituted triarylamine on the cyclometalated ligand by \u03c0-conjugation to improve the performance of the devices, 15 Heeger et\u00a0al. exhibited the cyclometalated with a fluorene moiety, 16 to enhance the solubility of the materials, Samuel et\u00a0al. introduced the rigid moiety with alkyl-fluorene. 17 H Tian et\u00a0al. made the highly efficient OLEDs by introduction rigid groups (carbazole, diphenylaniline) in the cyclometalated complexes. 18,19 However, there is few report on making iridium (III) complexes by modifying ancillary ligand. Kown et\u00a0al. reported a new functioned-ancillary ligand phosphorescent dendrimer system with carbazole via a non-conjugated bridge. 20 In this paper, we reported another way to make high-efficiency red-emitting iridium (III) complexes with better dispersibility in PLEDs. As alkyltrifluorene has a non-planar configuration, excellent carrier-transporting and soluble properties, attaching a alkyl-trifluorene into the ancillary ligand of picolinic acid by a non-conjugated connection of a 1,6-hexyloxy group is expected to make its heteroleptic iridium (III) complex obtain an improved dispersing ability and high-efficiency emission in PLEDs. We designed and synthesized an ancillary ligands of picolinic acid derivative of 6-(6\u2032-(9\u2033-octyl-2\u2033,7\u2033-bi(9,9-dioctylfluoren-2-yl)fluoren-9\u2033-yl)hexyloxy)picolinic acid (Tfl-picH) and its hetero-leptic iridium (III) complex of (Piq) 2 Ir(Tfl-pic). For\u00a0comparison, an analogous picolinic acid derivative of 6-(6\u2032-(2\u2033,7\u2033-dibromo-9\u2033-octylfluoren-9\u2033-yl)hexyloxy)picolinic acid (Brfl-picH) and its heteroleptic iridium (III) complex of (Piq) 2 Ir(Brfl-pic) were also made in which Piq is 1-phenylisoquinoline. The synthetic route of two iridium (III) complexes is shown in Scheme 1 . Their thermal and electrochemical properties, as well as optophysical were investigated. For higher thermal stability and better dispersibility, it is deserved for employing (Piq) 2 Ir(Tfl-pic) as guest, a blend of poly(9,9-dioctylfluorene) (PFO) and 2-(4-biphenyl)-5-(4- tert -butylphenyl)-1,3,4-oxadiazole (PBD) as a host matrix, also we obtained red emission with a current efficiency as high as 6.28 cdA \u22121 at 9.8 V. 2 Results and discussion 2.1 Synthesis 2,7-Dibromo-9-octyl-9-(6-bromohexyl)-9 H -fluorene ( 2 ) was prepared by a further nucleophilic substituted reaction of compound 1 with 1,6-dibromohexane in 71.0% yield. 21 Nucleophilic substitute of\u00a06-hydroxypicolinic acid with compound 2 provided methyl, 6-(6\u2032-(2\u2033,7\u2033-dibromo-9\u2033-octyl-fluoren-9\u2033-yl)hexyloxy)picolinate ( 3 ) in 82.3% yield. Hydrolysis of compound 3 provided an ancillary ligand of Brfl-picH in 91.8% yield. 2-(9,9-Dioctyl-9H-fluoren-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane ( 4 ) was synthesized by a Pd-catalyzed coupling reaction of bis(pinacolato)diboron with 2-bromo-9,9-dioctyl-9 H -fluorene in 78.0% yield. 22 Methyl, 6-(6\u2032-(9\u2033-octyl-2\u2033,7\u2033-bi(9,9- dioctyl fluoren-2-yl)fluoren-9\u2032-yl)hexyloxy) picolinate ( 5 ) was prepared from a Suzuki Pd-catalyzed coupling reaction between boronic ester ( 4 ) and compound 3 in 61.0% yield. 22 Hydrolysis of compound 5 provided an ancillary ligand of Tfl-picH in 95.0% yield. The iridium (III) complexes of (Piq) 2 Ir(Tfl-pic) and (Piq) 2 Ir(Brfl-pic) were synthesized by two-step procedures with a chloride-bridged reaction of iridium chloride trihydrate with 1-phenylisoquinoline and a chloride cleavage of the resulting chloro-bridged dimmers [(C^N) 2 IrCl] 2 with the ancillary ligand of Tfl-picH or Brfl-pic in over 50% yield based on the literatures. 10,23 As non-conjugated hexyloxy isolated effect, the Tfl-picH and Brfl-picH ligands have little effect on the chloride cleavage. Elemental analysis and 1 H NMR data of each of two iridium (III) complexes are consistent with the expected formula. 2.2 Optical analysis Figure\u00a01 shows the UV absorption spectra of these iridium (III) complexes in dichloromethane (DCM). Intense absorption band at about 352 nm and two weak absorption bands at about 405 nm and 468 nm are observed for each of two functionalized iridium (III) complexes, in which the intense high-lying absorption band is assigned to the intraligand-based \u03c0\u2013\u03c0 \u2217 transitions, and the weak low-lying absorption band is assigned to the singlet and triplet metal-ligand-charge-transfer ( 1 MLCT and 3 MLCT) transition, respectively. However, both of functionalized iridium (III) complexes presented more intense high-lying absorption band and weaker low-lying absorption bands than (Piq) 2 Ir(pic), 24 which have been reported by us, due to an introduction of the dibromoalkylfluorene or alkyl-trifluorene derivative into the common ancillary ligand of picolinic acid by non-conjugated connection of 1,6-hexyloxy group. In these iridium (III) complexes, (Piq) 2 Ir(Tfl-pic) displayed intenser high-lying absorption band. The UV absorption intensity is significantly influenced by the ancillary ligands of Tfl-picH and Brfl-picH. The photoluminescence (PL) spectra of these iridium (III) complexes are also shown in Figure\u00a01 . Nearly identical PL profiles are observed for (Piq) 2 Ir(Tfl-pic) and (Piq) 2 Ir(Brfl-pic) in DCM solution or neat films. Both iridium (III) complexes displayed red emission with a peak at 612 nm in DCM solution and 638 nm in neat film, which is mainly characteristic of MLCT emission. 10 Compared to (Piq) 2 Ir(pic), each of functionalized iridium (III) complexes exhibited minor red-shifted emission wavelength of 6 nm in solution and displayed a blue-shifted about 16 nm in neat film. It is due to the introduction with dibromoalkylfluorene or alkyltrifluorene derivative formed the conjugated system in solution. Also, the steric alkoxy and rigid fluorene construction have an effect on the intermolecular in neat film, which induce the hypsochromic shift. Consequently, the introduction of dibromoalkylfluorene and alkyltrifluorene derivatives into iridium (III) complexes can improve their PL quantum efficiency. The photoluminescence (PL) quantum yield ( \u03a6 PL ) was determined to be 0.62(\u00b110%) for (Piq) 2 Ir(Tfl-pic) and 0.66 (\u00b110%) for (Piq) 2 Ir(Brfl-pic) in degassed DCM solution at room temperature by using (Piq) 2 Ir(acac) as the standard ( \u03a6 PL =0.2), 25 which is three times higher than that of (Piq) 2 Ir(acac) and (Piq) 2 Ir(pic) ( Table 1 ). 2.3 Physical properties (TGA, DSC, and AFM) The thermal stability of these iridium (III) complexes was evaluated by TGA (heating rate of 20 \u00b0C/min) as shown in Figure\u00a0S1 . (Piq) 2 Ir(Tfl-pic) and (Piq) 2 Ir(Brfl-pic) exhibited a onset temperature of weight loss ( T d ) of 358 \u00b0C and 311 \u00b0C, respectively, which have a better stability than the (Piq) 2 Ir(pic) ( Table 1 ). Alkyltrifluorene moiety has better affected on thermal stability than dibromoalkylfluorene moiety in these iridium (III) complexes. In order to investigate their morphological property, the differential scanning calorimetry (DSC) was also measured under nitrogen atmosphere at a heating rate of 10 \u00b0C/min. As indicated in inset Figure\u00a0S1 , an endothermic peak centered at 121 and 122 \u00b0C was observed for (Piq) 2 Ir(Tfl-pic) and (Piq) 2 Ir(Brfl-pic), which corresponds to their melting point, respectively. The DSC curves revealed that both iridium (III) complexes are amorphous, which is particularly favored for making OLEDs because aggregation and crystallization will affect the device stability and lifetime significantly. 26 For comparison of dispersibility in polymer host matrix, the films of (Piq) 2 Ir(Tfl-pic) and (Piq) 2 Ir(Brfl-pic) doped into a blend of PBD and PVK were made, and their surface morphologies were recorded by atomic force microscopy (AFM), shown in Figure\u00a0S2 . The doped film with (Piq) 2 Ir(Brfl-pic) displayed a roughness with R a =0.672 nm and the other doped film with (Piq) 2 Ir(Tfl-pic) exhibited a roughness R a =0.242 nm, which indicates that (Piq) 2 Ir(Tfl-pic) has a better dispersibility than (Piq) 2 Ir(Brfl-pic) in the blend. The improved dispersibility of (Piq) 2 Ir(Tfl-pic) is attributed to the multi-octyl chains and twisted structure of the alkyltrifluorenes. 2.4 Electrochemical property The electrochemical behavior of these cyclometalated iridium (III) complexes was studied by cyclic voltammetry using ferrocene as the internal standard and the data are listed in Table 1 . Both of the iridium (III) complexes showed a sole reversible reduction wave ( E red ) rather than a reversible oxidation wave ( E ox ). Thus, the E ox had to be estimated by the energy band gap ( E g ) and E red according to the formula, E ox = E g + E red The energy band gap was generally estimated from the low-lying absorption edge data. As a result, the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) energy levels of these iridium (III) complexes, E LUMO and E HOMO , were calculated according to the following formula: E LUMO =\u2212( E red +4.34) and E HOMO =\u2212( E ox +4.34). 27 As LUMO and HOMO energies of PFO reported in literature were \u22122.1 eV and \u22125.8 eV, respectively, 28 both iridium (III) complexes here exhibited a matched energy level with the PFO host and are expected to have a carrier trap role and good electroluminescent performance in the PLEDs using PFO as a host. 2.5 Electroluminescent property As (Piq) 2 Ir(Tfl-pic) presented better integrated optical and physical and electrochemical properties, it was chose as emitter to make devices by solution process. The device configuration is ITO/PEDOT:PSS (50 nm)/PVK (50 nm)/(Piq) 2 Ir(Tfl-pic)+PFO\u2013PBD (45 nm)/Ba (4 nm)Al (150 nm) ( Fig.\u00a02 inset), in which ITO/PEDOT:PSS as the anode and Ba/Al as the cathode, PVK layer is the hole transport (HT) layer, PBD behaves as both a hole-blocker and an electron-transporter. In the emitting layer, the doping weight concentration of (Piq) 2 Ir(Tfl-pic) varied from 1 wt % to 8 wt %, PBD weight ratio was 30% in the PFO\u2013PBD blend. The electroluminescence (EL) spectra of the (Piq) 2 Ir(Tfl-pic) doped PFO\u2013PBD devices in the dopant concentrations from 1 wt % to 8 wt % are shown in Figure\u00a02 . Similar red-emitting EL spectra with a peak at about 608 nm and a shoulder at about 652 nm are observed in all of the devices. The fact that no emission from the host PFO+PBD appeared in the Ir (III) complex doped blend film indicated complete energy transfer from host to the Ir (III) complex expect 1 wt % doping concentration. The phenomenon with complete quenching of the host EL emission occurred at a much lower doping concentration has been attributed by some references to the charge-trapping mechanism (rather than to F\u00f6rster energy transfer) followed by recombination on the chromophore (Ir complex). 29 We also note that the shoulder intensity varied with the dopant concentrations. It firstly increases with increasing dopant concentrations from 1% to 2%, and then decreases with increasing dopant concentration from 2% to 8%. The dopant concentrations have significantly an influence on the mixing single and triplet emission of MLCT. Figure\u00a03 exhibits the current density-voltage-luminance (J-V-L) characteristics of the (Piq) 2 Ir(Tfl-pic) dopant PFO\u2013PBD devices in the doped concentrations from 1 wt % to 8 wt %. The applied voltage increases with increasing dopant concentrations at the given current density, which is attributed to the significant carrier-trap of this iridium (III) complex. The best device performance was obtained in the device at 4% dopant concentration. In order to compare to the performance difference of these devices with various dopant concentrations, the EL data of these devices were summarized in Table 2 and the current density-luminance efficiency characteristics of the devices are shown in Figure\u00a04 . The maximum luminance of 6549 cdm \u22122 and highest current efficiency of 6.28 cd/A were obtained in the device at 4% dopant concentration. The (Piq) 2 Ir(Tfl-pic) complex displayed better EL property than (Piq) 2 Ir(pic) in the PLEDs using PFO\u2013PBD as host matrix. 3 Conclusion Two red-emitting iridium (III) complexes containing dibromoalkylfluorene- and alkyltrifluorene-based picolinic acid were obtained. The iridium (III) complex with alkyl-trifluorene exhibited higher thermal stability, better dispersibility, and excellent emission quantum efficiency compared to the iridium (III) complex with dibromoalkylfluorene. High-efficiency emission with a maximum current efficiency as high as 6.2 cd/A and a maximum EL peak at 608 nm was observed in the alkyltrifluorene-containing iridium (III) complex-doped PFO\u2013PBD devices at 4% dopant concentration. This work indicates that an introduction of alkyltrifluorene into the common picolinic acid by a non-conjugated connection of 1,6-hexyloxy is available for improving its iridium (III) complex optophysical properties and EL properties in its doped PLEDs. 4 Experimental section 4.1 Materials All reagents were purchased from Aldrich, Acros or TCI companies. All reactions and manipulations were carried out under N 2 with the use of standard inert atmosphere and Schlenk techniques. 1 H NMR spectra were measured in CDCl 3 solution on a Bruker DPX (400 MHz) NMR spectrometer with tetramethylsilane (TMS) as the internal standard. Mass spectra (MS) were recorded on a Bruker Autoflex TOF/TOF (MALDI-TOF) instrument using dithranol as a matrix. UV\u2013vis absorption spectroscopy was measured by Shimadzu UV-265 spectrometer at room temperature. Fluorescence spectra were recorded on RF-5301 PC (Perkin Elmer) at room temperature in dichloromethane. Cyclic voltammograms (CV) were performed with a three electrode electrochemical cell in a 0.1 M tetra(n-butyl)-ammonium hexafluorophosphate (TBAPF 6 ) solution in acetonitrile with a scan 100 mV/s at room temperature under argon. A platinum wire and a KCl saturated Hg/HgO were used as\u00a0counter electrode and reference electrode, respectively. A\u00a0microplatinum ( \u00f8 =0.8 mm) was used as work electrode. 9-Octyl-9 H -fluorene was prepared by a nucleophilic substituted reaction of\u00a09 H -fluorene with octanol based on the literature. 30,31 2,7-Dibromo-9-octyl-9 H -fluorene ( 1 ) was synthesized by a bromination of 9-octyl-9 H -fluorene based on the procedure described by Ego. 19 2-Bromo-9,9-dioctyl-9 H -fluorene was synthesized based on the precedures. 32,33 The chloro-bridged dimmers of [(C^N) 2 IrCl] 2 were gained by the chloride-bridged reaction of iridium chloride trihydrate with 1-phenylisoquinoline based on previous literatures. 10,23 4.2 2,7-Dibromo-9-octyl-9-(6-bromohexyl)-9 H -fluorene ( 2 ) A mixture of 1 (2.63 g, 6.03 mmol), 1,6-dibromohexane (14.7 g, 60.3 mmol), aqueous sodium hydroxide (33%; 20 mL), and tetrabutyl ammonium bromide (TBAB, 0.1 g) was stirred vigorously under the protection of nitrogen for 1 d at 80 \u00b0C. The mixture was cooled to room temperature and extracted with DCM (3\u00d750 mL). The combined extracts were dried over magnesium sulfate and evaporated under reduced pressure. The excess 1,6-dibromohexane was recovered from the mixture by Kugelrohr distillation (180 \u00b0C, 0.1 mmHg). The crude product was purified by dry flash chromatography using hexane\u2013DCM (v/v, 1:0 changing to 4:1) as eluent to give the 2 (2.57 g, 71.0%) as a colorless oil. 1 H NMR (CDCl 3 , 400 MHz), \u03b4 (ppm): 7.54\u20137.52 (2H, d, J =8.0 Hz), 7.47\u20137.46 (2H, d, J =1.6 Hz), 7.45 (2H, s), 3.32\u20133.28 (2H, t), 1.95\u20131.90 (4H, t), 169\u20131.66 (2H, t), 1.23\u20131.05 (16H, m), 0.86\u20130.81 (5H, t). 4.3 Methyl-6-(6-(2,7-dibromo-9-octyl-9 H -fluoren-9-yl)hexyloxy)picolinate ( 3 ) To a stirred mixture of 6-hydroxypicolinic acid in CH 3 OH and H 2 SO 4 was added several drops benzene as dehydrate, the resulting mixture was refluxed for another 24 h under the protection of nitrogen. After cooled, the mixture was poured into brine and extracted with ethyl acetate (EA). The organic layer was washed with brine for three times and then dried over anhydrous Na 2 SO 4 . After removal of the solvent, the intermediate was gained. Then a mix of this intermediate (0.61 g, 4.0 mmol), compound 2 (2.0 g, 3.34 mmol), acetone (60 mL), K 2 CO 3 (4.0 g, 40 mmol), and KI (0.5 g), the resulting mixture was refluxed for another 24 h. After cooled, the mixture was poured into brine and extracted with DCM. The organic layer was washed with brine for three times and then dried over anhydrous Na 2 SO 4 . After removal of the solvent, the crude product was purified by dry flash chromatography using petrol ether (PE)\u2013EA (v/v, 10:1) as eluent to give the 5 (1.84 g, 82.3%) as a white solid. 1 H NMR (CDCl 3 , 400 MHz), \u03b4 (ppm): 7.68\u20137.62 (2H, m), 7.52\u20137.50 (2H, d, J =7.92 Hz), 7.45\u20137.43 (2H, d, J =7.92 Hz), 4.28\u20134.25 (2H, t), 3.94 (3H, s), 1.94\u20131.89 (4H, m), 1.62\u20131.57 (2H, m), 1.25\u20131.04 (14H, m), 0.84\u20130.81 (3H, t), 0.59\u20130.58 (4H, m). 4.4 6-(6-(2,7-Dibromo-9-octyl-9 H -fluoren-9-yl)hexyloxy)picolinic acid (Brfl-picH) A mixture of compound 3 (1.0 g, 1.5 mmol), NaOH (50%, 5 mL), anhydrous ethanol (5 mL), THF (10 mL) was stirred vigorously for 2 h at 60 \u00b0C, then for another 24 h at room temperature. The mixture was poured into water and extracted with DCM and the combined organic layer was dried over anhydrous magnesium sulfate. The solvent was removed by rotary evaporation and gain Brfl - picH (0.9 g, 91.8%) as a white solid. 1 H NMR (CDCl 3 , 400 MHz), \u03b4 (ppm): 7.81 (2H, s), 7.53\u20137.51 (2H, d, J =7.88), 7.46\u20137.44 (4H, d, J =8.0), 6.98\u20136.96 (1H, d, J =7.44 Hz), 4.22\u20134.19 (2H, t), 1.96\u20131.89 (2H, t), 1.27\u20131.05 (20H, m), 0.84\u20130.81 (3H, t). 4.5 2-(9,9-Dioctyl-9 H -fluoren-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane ( 4 ) A nitrogen-flushed three-neck round bottom flask was charged with 2-bromo-9,9-dioctyl-9 H -fluorene (4.0 g, 8.5 mmol), bis(pinacolato)diboron (2.38 g, 9.4 mmol), potassium acetate (2.5 g, 25.5 mmol), and [1,1\u2032-bis(diphenylphosphino)-ferrocene] dichloroplladium (0.27 mg, 0.34 mmol), complex with dichloromethane (1:1). Dimethyl sulfoxide (DMSO, 60 mL) was then added, and the mixture was bubbled with nitrogen for 15 min. After the reaction mixture was heated at 80 \u00b0C for 19 h, it was cooled to room temperature and poured into ice-water (200 mL). It was then extracted with DCM (3\u00d720 mL) and the combined organic layer was dried over anhydrous magnesium sulfate. The solvent was removed by rotary evaporation and the residue was passed through a flash silica gel column with PE\u2013DCM (v/v, 4:1) as the eluent to give white crystals (3.42 g, yield 78.0%). 1 H NMR (CDCl 3 , 400 MHz), \u03b4 (ppm): 7.81\u20137.79 (2H, d, J =7.6 Hz), 7.74\u20137.69 (4H, m), 7.32\u20137.31 (2H, d, J =5.52 Hz), 2.00\u20131.96 (4H, t), 1.39 (12H, s), 1.20\u20131.02 (20H, m), 0.83\u20130.79 (6H, t), 0.59\u20130.58 (4H, m). 4.6 Methyl-6-(6-(7-(9,9-dioctyl-9 H -fluoren-2-yl)-9,9\u2032,9\u2032-trioctyl-2,2\u2032-bi(9 H -fluoren)-9-yl)hexyl)picolinate ( 5 ) To a mixture of compound 3 (1.0 g, 1.49 mmol), compound 4 (0.85 g, 1.64 mmol), and tetrakis(triphenylphosphine) palladium [Pd(PPh 3 ) 4 ] (86 mg) was added a degassed mixture of toluene (20 mL), anhydrous ethanol (10 mL) and 2 M potassium carbonate aqueous solution (10 mL). The mixture was refluxed for 24 h under the protection of nitrogen. After cooled, the mixture was poured into water (200 mL). It was extracted with DCM (3\u00d720 mL) and the combined organic layer was dried over anhydrous magnesium sulfate. The solvent was removed by rotary evaporation and the\u00a0residue was passed through a flash silica gel column with PE\u2013EA (v/v, 25:1) as the eluent to give an oil product. (1.16 g, yield 61.0%). 1 H NMR (CDCl 3 , 400 MHz), \u03b4 (ppm): 7.86\u20137.76 (6H, m), 7.71\u20137.6 (10H, m), 7.41\u20137.34 (6H, m), 6.85\u20136.83 (1H, d, J =7.98 Hz), 4.32\u20134.28 (2H, t), 3.95 (3H, s), 2.08\u20132.05 (12H, t), 1.29\u20131.11 (56H, m), 0.86\u20130.82 (15H, t), 0.76\u20130.75 (12H, m). 4.7 6-(6-(7-(9,9-Dioctyl-9 H -fluoren-2-yl)-9,9\u2032,9\u2032-trioctyl-2,2\u2032-bi(9 H -fluoren)-9-yl)hex-yl) picolinic acid (Tfl-picH) A mixture of compound 5 (1.0 g, 0.78 mmol), NaOH (50%, 5 mL), anhydrous ethanol (5 mL), THF (10 mL) was stirred vigorously for 2 h at 60 \u00b0C, then for another 24 h at room temperature. The mixture was poured into water and extracted with DCM and the combined organic layer was dried over anhydrous magnesium sulfate. The solvent was removed by rotary evaporation and gain Tfl - picH (0.93 g, 95.0%) as a white solid. 1 H NMR (CDCl 3 , 400 MHz), \u03b4 (ppm): 7.86\u20137.76 (6H, m), 7.71\u20137.6 (10H, m), 7.41\u20137.34 (6H, m), 6.85\u20136.83 (1H, d, J =7.98 Hz), 4.32\u20134.28 (2H, t), 2.08\u20132.05 (12H, t), 1.29\u20131.11 (56H, m), 0.86\u20130.82 (15H, t), 0.76\u20130.75 (12H, m). 4.8 Synthesis of (Piq) 2 Ir(Tfl-pic) To a mixture of IrCl 3 \u00b73H 2 O (0.3 g, 0.85 mmol) and water (5 mL) was added 1-phenylisoquinoline (0.5 g, 2.44 mmol) and 2-ethoxyethanol (15 mL). The mixture was refluxed under inert gas atmosphere for 20 h. After cooled, the colored precipitate was filtered off and was washed with water, followed by hexane. Then gain a red solid (0.42 g, 78.0%). A mixture of [(C^N) 2 IrCl] 2 dimmers (0.2 g, 0.16 mmol), compound Tfl - picH (0.5 g, 0.4 mmol), and 85\u201390 mg of sodium carbonate were refluxed under inert gas atmosphere in 2-ethoxyethanol for 12\u201315 h. After cooling to room temperature, extracted with DCM and the combined organic layer was dried over anhydrous magnesium sulfate. The crude product was purified by dry flash silica gel column with DCM to gain the goal product (0.28 g, 53.0%) as a red solid. 1 H NMR (CDCl 3 , 400 MHz), \u03b4 (ppm): 8.95\u20138.92 (1H, d, J =8.4 Hz), 8.82\u20138.80 (1H, d, J =9.52 Hz), 8.62\u20138.60 (1H, d, J =6.4 Hz), 8.12\u20138.10 (1H, d, J =7.6 Hz), 8.04\u20138.03 (1H, d, J =7.2 Hz), 7.94\u20137.92 (1H, d, J =7.2 Hz), 7.83\u20137.57 (23H, m), 7.36\u20137.34 (6H, d, J =7.2 Hz), 7.15\u20137.14 (1H, d, J =6.4 Hz), 6.89\u20136.86 (1H, t), 6.66\u20136.61 (2H, t), 6.58\u20136.56 (1H, d, J =8.0 Hz), 6.46\u20136.42 (1H, t), 6.3\u20136.28 (1H, d, J =8.0 Hz), 6.17\u20136.15 (1H, d, J =7.2 Hz), 4.27\u20134.26 (2H, t), 2.07\u20132.0 (12H, t), 1.26\u20131.06 (56H, m), 0.81\u20130.68 (27H, m). Anal. Calcd for C 121 H 140 IrN 3 O 3 : C 77.44, H 7.52, N 2.24. Found: C 78.94, H 7.60, N 2.34%. TOF-MS (M+Na + ): 1890. 4.9 Synthesis of and (Piq) 2 Ir(Brfl-pic) It was prepared according to the synthetic procedure of (Piq) 2 Ir(Tfl-pic). A red solid was obtained with a yield of 56.0%. 1 H NMR (CDCl 3 , 400 MHz), 8.97\u20138.95 (1H, m), 8.86\u20138.84 (1H, d, J =9.6 Hz), 8.64\u20138.62 (1H, d, J =6.4 Hz), 8.14\u20138.12 (1H, d, J =8.4 Hz), 8.10\u20138.08 (1H, d, J =7.6 Hz), 7.97\u20137.95 (1H, d, J =7.6 Hz), 7.84\u20137.77 (3H, m), 7.72\u20137.60 (6H, m), 7.53\u20137.50 (2H, m), 7.46\u20137.42 (4H, m), 7.37\u20137.36 (1H, d, J =6.4 Hz), 7.20\u20137.18 (1H, d, J =6.4 Hz), 6.91\u20136.81 (1H, t), 6.70\u20136.62 (3H, m), 6.48\u20136.44 (1H, t), 6.33\u20136.31 (1H, d, J =7.6 Hz), 6.18\u20136.16 (1H, d, J =7.6 Hz), 4.28\u20134.25 (2H, t), 1.94\u20131.89 (4H, m), 1.62\u20131.57 (2H, m), 1.25\u20131.04 (14H, m), 0.84\u20130.81 (3H, t), 0.59\u20130.58 (4H, m). Anal. Calcd. For C 62 H 56 Br 2 IrN 3 O 3 : C 59.90, H 4.54, N 3.38. Found: C 60.73, H 4.94, N 3.30%. Acknowledgements Financial support from the National Natural Science Foundation of China ( 20772101 ), the Science Foundation of Human Province ( 2009FJ2002 and 2007FJ3017 ) and the Postgraduate Science Foundation for Innovation in Human Province ( CX2009B124 and S2008 yjscx09). Supplementary data TGA thermogram graph, DSC traces and atomic force microscope images for the (Piq) 2 Ir(Tfl-pic) and (Piq) 2 Ir(Brfl-pic) complexes were provided. Supplementary data TGA thermogram graph, DSC traces and atomic force microscope images for the (Piq) 2 Ir(Tfl-pic) and (Piq) 2 Ir(Brfl-pic) complexes were provided. Supplementary data associated with this article can be found in the online version at doi:10.1016/j.tet.2009.12.001 . References and notes 1 C.W. Tang S.A. VanSlyke C.H. Chen J. Appl. Phys. 65 1989 3610 3616 2 (a) R.C. Evans P. Douglas C.J. Winscom Coord. Chem. Rev. 250 2006 2093 2126 (b) M.E. Thompson MRS Bull. 32 2007 694 701 (c) F. So B. Krummacher M.K. Mathai D. Poplavskyy S.A. 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Leclerc Macromolecules 30 1997 7686 7691 33 H.N. Cho J.K. Kim D.Y. Kim C.Y. Kim N.W. Song D. Kim Macromolecules 32 1999 1476 1481",
        "keywords": [
            "fluorene",
            "iridium (iii)",
            "oleds/pleds",
            "synthesis",
            "thermal stability",
            "quantum efficiency",
            "electroluminescence"
        ],
        "authors": [
            {
                "name": "Yafei Wang",
                "org": "Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Hua Tan",
                "org": "Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Yu Liu",
                "org": "Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Chenxian Jiang",
                "org": "Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Zhengyong Hu",
                "org": "Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Lei Wang",
                "org": "Institute of Polymer Optoelectronic Material and Devices, South China University of Technology, Guangzhou 510640, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            },
            {
                "name": "Yong Cao",
                "org": "Institute of Polymer Optoelectronic Material and Devices, South China University of Technology, Guangzhou 510640, China"
            }
        ],
        "venue": "Tetrahedron",
        "year": 2010
    },
    "Cgt3b9bW": {
        "id": "Cgt3b9bW",
        "title": "Red Electrophosphorescence from Oxadiazoles-Functionalized Iridium Complexes in Polymer Light-Emitting Devices",
        "abstract": "",
        "keywords": [
            "current density"
        ],
        "authors": [
            {
                "name": "Wu Zhong-Lian",
                "org": ""
            },
            {
                "name": "Luo Cui-Ping",
                "org": ""
            },
            {
                "name": "Hu Zheng-Yong",
                "org": ""
            },
            {
                "name": "Jiang Chang-Yun",
                "org": ""
            },
            {
                "name": "Huang Feng-Liang",
                "org": ""
            },
            {
                "name": "Zhu Ke-Ming",
                "org": ""
            },
            {
                "name": "Zhu Mei-Xiang",
                "org": ""
            },
            {
                "name": "Zhu Wei-Guo",
                "org": ""
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2006
    },
    "fVsRGoMo": {
        "id": "fVsRGoMo",
        "title": "Synthesis and photophysical and electrochemical properties of new cyclometalated platinum complex containing oxadiazole ligand",
        "abstract": "A new cyclometalated platinum complex containing 2, 5-bis(naphthalene-1-yl)-1,3,4-oxadiazole ligand was synthesized and characterized.\n The UV-Vis absorptions and photoluminescent properties of the ligand and its platinum complex were investigated. A characteristic\n metal-ligand charge transfer absorption peak at 439 nm in the UV spectrum and a strong emission peak at 625 nm in the photoluminescence\n spectrum were observed for this complex in dichloromethane. Cyclic voltammtry (CV) analysis shows that the E\n HOMO (energy level of the highest occupied molecular orbital) and E\n HOMO (energy level of the lowest unoccupied molecular orbital) of the platinum complex are about \u22125.69 and \u22123.25 eV, respectively,\n indicating that the oxadiazole-based platinum complex has a potential application in electrophosphorescent devices used as\n a red-emitting material.",
        "keywords": [
            "photoluminescence",
            "synthesis",
            "cyclometalated platinum complex",
            "oxadiazole",
            "electrochemical property",
            "energy levels",
            "charge transfer",
            "spectrum",
            "lowest unoccupied molecular orbital",
            "highest occupied molecular orbital"
        ],
        "authors": [
            {
                "name": "Ji-yong Deng",
                "org": "Xiangtan University School of Chemistry Xiangtan 411105 China Xiangtan 411105 China"
            },
            {
                "name": "Yu Liu",
                "org": "Xiangtan University School of Chemistry Xiangtan 411105 China Xiangtan 411105 China"
            },
            {
                "name": "Zheng-yong Hu",
                "org": "Xiangtan University School of Chemistry Xiangtan 411105 China Xiangtan 411105 China"
            },
            {
                "name": "Mei-xiang Zhu",
                "org": "Xiangtan University School of Chemistry Xiangtan 411105 China Xiangtan 411105 China"
            },
            {
                "name": "Wei-guo Zhu",
                "org": "Xiangtan University School of Chemistry Xiangtan 411105 China Xiangtan 411105 China"
            }
        ],
        "venue": "Journal of Central South University of Technology",
        "year": 2007
    },
    "oOG08alG": {
        "id": "oOG08alG",
        "title": "Red polymer light-emitting devices based on an oxadiazole-functionalized europium(III) complex",
        "abstract": "A novel tris(dibenzoylmethanato)[5-(2-(4-tert-butylbenzenyl)-5-benzenyl-1, 3,4-oxadiazole-4\ufffd\ufffd)-1,10-phenanthroline]europium(III) [Eu(DBM) 3(BuOXD-Phen)] containing an electron-transporting oxadiazole-functionalized phenanthroline ligand was synthesized and characterized. Its UV-vis absorption and photoluminescence (PL), as well as the electroluminescence (EL) in polymer light-emitting devices (PLEDs) were investigated. The double-layer PLEDs with a configuration of ITO/PEDOT:PSS (50 nm)/PVK (40 nm)/PFO:PBD (30%):Eu(DBM)3(BuOXD-Phen) (1-8 wt %) (80 nm)/Ba (4 nm)/Al (150 nm) were fabricated. Saturated red Eu3+ ion emission, based on the 5D0 \ufffd\ufffd 7F 2 transition, is centered at a wavelength of 614 nm with a full width at half maximum (FWHM) of 10 nm. The highest external quantum efficiency (QEext) of 1.26% at current density of 1.65 mA cm-2, with a maximum brightness of 568 cd m-2 at 137.8 mA cm-2 was achieved from the device at 1 wt % dopant concentration. ? 2013 Elsevier B.V. All rights reserved.",
        "keywords": [
            "electrochemical properties",
            "luminescence",
            "organometallic compounds",
            "polymers"
        ],
        "authors": [
            {
                "name": "Yu Liu,",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yafei Wang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Chun Li",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            },
            {
                "name": "Ying Huang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Dongfeng Dang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yong Cao",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            }
        ],
        "venue": "Materials Chemistry and Physics",
        "year": 2014
    },
    "fFcGlSEG": {
        "id": "fFcGlSEG",
        "title": "Polymer light-emitting devices based on europium(III) complex with 11-bromo-dipyrido[3,2-<Emphasis Type=\"Italic\">a</Emphasis>:2\u2032,3\u2032-<Emphasis Type=\"Italic\">c</Emphasis>]phenazine",
        "abstract": "Polymer light-emitting diodes (PLEDs) containing Eu(DBM)3(BrDPPz) (DBM is dibenzoylmethane, and BrDPPz is 11-bromo-dipyrido[3,2-a:2\u2032,3\u2032-c]phenazine) doped in a blend of poly(9,9-dioctylfluorene) (PFO) and 2-tert-butylphenyl-5-biphenyl-1,3,4-oxadiazole (PBD) as the host matrix are reported. Eu(DBM)3(BrDPPz) exhibited high thermal stability and intense UV-Vis absorption. Narrow-bandwidth red emission at 612 nm with a full width at half-maximum (FWHM) of 14.0 nm was observed from Eu(DBM)3(BrDPPz) in these double-layered PLEDs at dopant concentrations from 1 wt% to 8 wt%. For the PLED containing 1 wt% Eu(DBM)3(BrDPPz), a maximum luminance of 829 cd/m2 at 153.5 mA/cm2, highest external quantum efficiency of 1.70% at 2.1 mA/cm2 and maximum luminance of 0.74 cd/A at 4.31 mA/cm2 were obtained.",
        "keywords": [
            "europium(III) complexes",
            " electroluminescence",
            " optophysical properties",
            " polymer light-emitting diodes"
        ],
        "authors": [
            {
                "name": "Qunping\u00a0Fan",
                "org": "Key Laboratory of Environment-Friendly Chemistry and Application of the Ministry of Education; College of Chemistry,Xiangtan University,Xiangtan,China"
            },
            {
                "name": "Yu\u00a0Liu",
                "org": "Key Laboratory of Environment-Friendly Chemistry and Application of the Ministry of Education; College of Chemistry,Xiangtan University,Xiangtan,China"
            },
            {
                "name": "Zhaoran\u00a0Hao",
                "org": "Key Laboratory of Environment-Friendly Chemistry and Application of the Ministry of Education; College of Chemistry,Xiangtan University,Xiangtan,China"
            },
            {
                "name": "Chun\u00a0Li",
                "org": "Institute of Polymer Optoelectronic Material and Devices,South China University of Technology,Guangzhou,China"
            },
            {
                "name": "Yafei\u00a0Wang",
                "org": "Key Laboratory of Environment-Friendly Chemistry and Application of the Ministry of Education; College of Chemistry,Xiangtan University,Xiangtan,China"
            },
            {
                "name": "Hua\u00a0Tan",
                "org": "Key Laboratory of Environment-Friendly Chemistry and Application of the Ministry of Education; College of Chemistry,Xiangtan University,Xiangtan,China"
            },
            {
                "name": "Weiguo\u00a0Zhu",
                "org": "Key Laboratory of Environment-Friendly Chemistry and Application of the Ministry of Education; College of Chemistry,Xiangtan University,Xiangtan,China"
            },
            {
                "name": "Yong\u00a0Cao",
                "org": "Institute of Polymer Optoelectronic Material and Devices,South China University of Technology,Guangzhou,China"
            }
        ],
        "venue": "Science China Chemistry",
        "year": 2015
    },
    "5fBYCCYh": {
        "id": "5fBYCCYh",
        "title": "Synthesis and characteristics of a europium complex using pyridyl oxadiazole derivative as a secondary ligand",
        "abstract": "A novel europium complex using 2-(4-methoxy)phenyl-5-(2-pyridyl)-1,3,4-oxadiazole as a secondary ligand was synthesized and characterized. Its thermal stability and UV absorption and photoluminescence of this europium complex, as well as its electroluminescence in polymer light-emitting devices (PLEDs) were investigated. The results show that this europium complex displayed intense UV absorption band around 350 nm and sharp red emission peaked at 612 nm with a full width at half maximum of 9 nm in chloroform. The PLEDs with this europium complex doped into a blend of poly( N -vinylcarbazole) and 5-biphenyl-2-(4- tert -butylphenyl)-1,3,4-oxadiazole exhibited a light intensity of 12 cd/m 2 at 24 V with a characteristic red emission of europium ion at 613 nm. This implies that the europium complex using the pyridyl 1,3,4-oxadiazole derivative as a secondary ligand can exhibit intense sharp emission of europium ion under opto-excitation and electric-excitation. PACS 81.05.Lg 78.60.Fi 85.60.Jb Keywords Europium complex Oxadiazole Photoluminescence Electroluminescence 1 Introduction Europium complexes have attracted a great deal of attention because of their highly monochromatic red emission and 100% theoretical emission quantum efficiency in organic and polymeric light-emitting devices (OLEDs and PLEDs) in recent decades [1\u201315] . Most of the reported europium complexes used in these devices were obtained by using \u03b2-diketone derivatives as primary ligands and phenanthroline derivatives as secondary ligands. A maximum external quantum efficiency of 7.5% was demonstrated in the OLEDs using tri(dibenzoylmethane) (4,7-biphenyl-1,10-phenanthroline) europium(III) [Eu(DBM) 3 (Bphen)] as a dopant and triphenyldiamine (TPD) as a host matrix [3] , and a peak external quantum efficiency of 1.1% was exhibited in the PLEDs using tris(dinaphthoylmethane) (1,10-phenanthroline) Eu(DNM) 3 phen as a dopant and poly[2-(6\u2032-cyano-6\u2032-methylheptyloxy)-1,4-phenylene] (CNPPP) as a host matrix [4] . Compared to iridium complexes-doped devices, the europium complexes-doped devices display low efficiency and have not presented satisfactory luminous properties for their commercial application. One important reason is possible that europium complexes have poor ability to transport charge carriers, which is unfavorable for high-efficiency emission of europium complexes [6,7] . The other important reason we suspect is that europium complexes easily present molecular aggregation and concentration quenching. Therefore, most of the works were focused on the functionalized europium complexes by incorporating the ligands with carrier-transporting groups in the complexes in order to elevate luminescent efficiency of europium complexes [6\u201312] . Liang et al. exhibited the 1-{4-[4-(5-phenyl-1,3,4-oxadiazole-2-yl)phenoxy]butyl}-(2-pyridin-2-yl)-1 H -benzo[ d ]imidazole (OXD-PyBM)-based europium complex-doped OLEDs with an external quantum efficiency of 1.7% [7] , and Xiang et al. reported the preparation of the 1-(4-(5-(4-methylphenyl)-1,3,4-oxadiazole-2-yl)biphenyl-4-yl)-4,4,4-trifluobutane-1,3-dione [8] . However, the europium complexes using pyridyl oxadiazole derivatives as secondary ligands have not been reported yet. In this paper, we reported our initial work on achieving a novel functionalized europium complex using a pyridyl oxadiazole derivative as a secondary ligand. In this europium complex, dibenzoylmethane (DBM) is chosen as the first ligand due to its relatively high PL efficiencies. The pyridyl oxadiazole derivative is included as the secondary ligand since it may enhance the electron-transporting ability of its europium complexes and saturate the coordination number of europium ion, as well as improve the stability of the europium complex and suppress molecular aggregation owing to that the secondary ligand of oxadiazole derivative has good electron-transporting ability and non-planar molecular structure [7,16] . The designed europium complexes is tris(dibenzoylmethane) [2-(4-methoxy) phenyl-5-(2-pyridyl)-1,3,4-oxadiazole] europium [Eu(DBM) 3 (MeO-OXD)]. Its synthetic route is shown in Scheme 1 . 2 Experimental 2.1 Reagents and apparatus All chemicals used were of an analytical grade. Solvents were purified with conventional methods. All NMR spectra were acquired at a Bruker Dex-400NMR instrument using CDCl 3 as solvent. Elemental analyse was performed with a PerkinElmer 240 instrument. Thermogravimetic (TG) analysis was carried out with a NETZSCH STA 449 in nitrogen atmosphere at a heating rate of 10 \u00b0C/min from 10 \u00b0C to 700 \u00b0C. Differential scanning calorimetry (DSC) was carried out with a NETZSCH DSC 204 in nitrogen atmosphere at a heating rate of 30 \u00b0C/min from 25 \u00b0C to 700 \u00b0C. UV\u2013vis spectra were recorded with a HP-8453 System and corrected by subtracting backgrounds. The Eu(DBM) 3 (MeO-OXD)-doped PLEDs were fabricated on a cleaned ITO glass substrate with a sheet resistance of 15 \u03a9 \u22122 according to our previous work [17] . Typical active area of the devices was 0.15 mm 2 . I \u2013 V characteristics were measured with a computerized Keithley 236 source measure unit. Luminance was measured with a calibrated photodiode. PL spectra under excitation of 325 nm line from a He\u2013Cd laser (OmniChrome Co.) and EL spectra were recorded with an InstaSpec IV CCD system (Oriel). All the fabricated devices have a configuration of ITO/PEDOT: PSS, 50 nm/PVK, 40 nm/Eu(DBM) 3 (MeO-OXD) + PVK-PBD, 80 nm/Ba, 4 nm/Al, 150 nm. The mass ratio of Eu(DBM) 3 (MeO-OXD) and PBD was 2% and 30% in the devices, respectively. 2.2 Synthesis of ligand and complex 2-(4-Methoxy) phenyl-5-(2-pyridyl)-1,3,4-oxadiazole (MeO-OXD) was synthesized according to our previous work [18] . mp 154\u2013156 \u00b0C. 1 H NMR (400 Hz, CDCl 3 , \u03b4 ppm): 8.83 (d, 1H), 8.32 (d, 1H), 8.17 (d, 2H), 7.92 (t, 1H), 7.48 (d, 1H), 7.04 (d, 2H), 3.89 (s, 3H). C 14 H 11 N 3 O 2 Calcd (%): C, 66.40; H, 4.38; N, 16.59. Found (%): C, 66.03; H, 4.31; N, 16.82. Synthesis of Eu(DBM) 3 (MeO-OXD): a solution of dibenzoylmethane (224 mg, 1.0 mmol), 2-(4-methoxy)phenyl-5-(2-pyridyl)-1,3,4-oxadiazole (84 mg, 0.33 mmol) and ethanol (20 mL) was neutralized with sodium hydroxide solution (1.0 mol/L) to pH 7 in a flask under nitrogen atmosphere. A solution of europium chloride (85 mg, 0.33 mmol) and water (2.0 mL) was then added dropwise into the flask with stirring. The mixed solution was stirred at 65\u201370 \u00b0C for 3.0 h. The formed yellow precipitate was filtered, washed with water and ethanol, and recrystallized with chloroform and petroleum to afford Eu(DBM) 3 (MeO-OXD) with a yield of 72.0%, mp 222\u2013224 \u00b0C. EuC 59 H 44 N 3 O 8 Calcd (%): C, 65.92; H, 4.13; N, 3.91. Found (%): C, 65.86; H, 4.02; N, 3.83. 3 Results and discussion The thermal properties of Eu(DBM) 3 (MeO-OXD) were studied by thermogravimetry and differential scanning calorimetry. The TG and DSC curves of Eu(DBM) 3 (MeO-OXD) were recorded in Fig. 1 . The endothermic peak appears at 293 \u00b0C in the DSC curve. No weight loss is observed at 293 \u00b0C in the TG curve. The europium complex is decomposed and has a striking weight loss around 310 \u00b0C. This is attributed to the removal of the secondary ligand of 2-(4-methoxy)phenyl-5-(2-pyridyl)-1,3,4-oxadiazole from the europium complex. The fact that the decomposition temperature of Eu(DBM) 3 (MeO-OXD) is as high as 310 \u00b0C indicates that this complex with pyridyl oxadiazole derivative presents a high-thermal stability. Fig. 2 shows the UV\u2013vis absorption spectra of the Eu(DBM) 3 (MeO-OXD) complex. The intense UV\u2013vis absorption of Eu(DBM) 3 (MeO-OXD) was observed in the absorption profile of its chloroform solution and neat film. The maximum absorption peaks locate at 350 nm for the solution and 359 nm for the neat film, which are assigned to the \u03c0\u2013\u03c0* transition absorption of this europium complex [15] . The absorption band of the neat film is red-shift compared to that of the solution, which is in accordance with the intermolecular effect. Note that Eu(DBM) 3 (MeO-OXD) has almost the same maximum absorption to tris(dibenzoylmethane) (mono-phenanthroline) europium[Eu(DBM) 3 Phen] [15] . This implies that MeO-OXD instead of phenanthroline as secondary ligand has less influence on the absorption of its europium complex. Fig. 3 shows the PL emission spectra of the Eu(DBM) 3 (MeO-OXD) complex in chloroform and the doped PVK-PBD film at 2% dopant concentration and the PL spectra of the PVK and PBD films, respectively. The same PL profiles with intense sharp red emission are exhibited for the europium complex in chloroform and the doped film under excitation of 325 nm line from a He\u2013Cd laser. Four peaks at 586 nm, 612 nm, 652 nm, 701 nm are presented in the PL profiles, which are assigned to 5 D 0 \u2192 7 F 1 , and 5 D 0 \u2192 7 F 2 , 5 D 0 \u2192 7 F 3 , 5 D 0 \u2192 7 F 4 transitions of europium ion, respectively, as ascribed by O\u2019Riordan et al. [15] . No emission peaked at 394 nm and 417 nm from the PVK-PBD blend is observed, indicating that the emission of the doped film is dominated by Eu(DBM) 3 (MeO-OXD) and the emission from the blend is completely quenched by the emission of this europium complex. This implies that the energy transfer from the blend to this europium complex was efficient under opto-excitation. Based on the PL result, the Eu(DBM) 3 (MeO-OXD) complex with the pyridyl oxadiazole derivative should be used as a red emitter in the PLEDs [15,4,16] . In order to confirm the speculation, we made preliminary study on the EL properties of the Eu(DBM) 3 (MeO-OXD) complex in PLEDs. The fabricated device with Eu(DBM) 3 (MeO-OXD) doped into the PVK-PBD blend displayed an EL emission with a light intensity of 12 cd/m 2 at 24 V. The EL spectrum of the device is shown in Fig. 4 . A sharp red emission at 613 nm with a full width at half maximum (FWHM) of 9 nm is observed in the device under electric-excitation. This indicates that the europium complex with pyridyl oxadiazole derivative as a secondary ligand has a potential to be used as a red electroluminescent material although it has not displayed satisfactory light intensity in the device. We speculate that low light intensity is related to the luminous efficiency of this europium complex in the host matrix and unbalanced carriers injection in the emitting layer due to the influence of the host structure and the two-layered device configuration. Therefore, studies on the electrochemical properties of this europium complex and PL efficiency in the doped polymer film, further the optimization of host matrix and device configuration need to be carried out in order to achieve high-efficiency Eu(DBM) 3 (MeO-OXD)-doped PLEDs with high-light intensity. The related works are currently ongoing. 4 Conclusion A Eu(DBM) 3 (MeO-OXD) complex with a pyridyl oxadiazole derivative was achieved and characterized. This Eu(DBM) 3 (MeO-OXD) in solid state exhibited high-thermal stability with a decomposition temperatures of 310 \u00b0C and intense UV absorption peak at 359 nm, as well as strong narrow bandwidth emission peaked at 612 nm with a full width at half maximum of 9 nm. Efficient energy transfer occurs from the PVK-PBD blend to this europium complex in the doped film and device under opto- and electric-excitation, respectively. Red EL emission at 613 nm with FWHM of 9 nm was observed in the Eu(DBM) 3 (MeO-OXD)-doped PVK-PBD device. Acknowledgments The authors would like to thank the National Natural Science Foundation of China (Nos. 50473046 and 20772101), Hunan Provincial Science Foundation (Nos. 2007FJ3017 and 06JJ2008) and the Science Foundation of the Education Department of Hunan Province (07C764) for their financial support. References [1] Z. Hong C. Liang R. Li W. Li D. Zhao D. Fan D. Wang B. Chu F. Zhang L.S. Hong S.T. Lee Adv. Mater. 13 2001 1241 [2] Q.D. Liang Q.J. Cai E.T. Kang K.G. Neoh F.R. Zhu W. Huang J. Mater. Chem. 4 2004 2741 [3] T.W. Canzler J. Kido Org. Electron. 7 2006 29 [4] M.D. McGehee T. Bergstedt C. Zhang A.P. Saab M.B. O\u2019Regan G.C. Bazan A.I. Srdanov A.J. Heeger Adv. Mater. 11 16 1999 1349 [5] M. Shi F. Li T. Yi D. Zhang H. Hu C. Huang Inorg. Chem. 44 2005 8929 [6] M.R. Robinson M.R. O\u2019Regan G.C. Bazan Chem. Commun. 2000 1645 [7] F. Liang Q. Zhou X. Cheng L. Wang D. Ma X. Jiang F. Wang Chem. Mater. 15 2003 1935 [8] N.J. Xiang L.M. Leung S.K. So M.L. Gong Spectrochim. Acta Part A 65 2006 907 [9] P. Sun J. Duan H. Shih C. Chang Appl. Phys. Lett. 81 2002 792 [10] M. Sun H. Xin K.Z. Wang Y.A. Zhang L.P. Jin C.H. Huang Chem. Commun. 2003 702 [11] H. Xin M. Sun K.Z. Wang Y.A. Zhang L.P. Jin C.H. Huang Chem. Phys. Lett. 388 2004 55 [12] J. Pei X. Liu W. Yu Y. Lai Y. Liu Y. Cao Macromolecules 35 2002 7274 [13] N.A.H. Male O.V. Salata V. Christou Synth. Met. 126 2002 7 [14] X.Z. Jiang A.K.Y. Jen G.D. Phelan D.Y. Huang T.M. Londergan L.R. Dalton R.A. Register Thin Solid Films 416 2002 212 [15] A. O\u2019Riordan E. O\u2019Connor S. Moynihan X. Llinares R.V. Deun P. Fias P. Nockemann K. Binnemans G. Redmond Thin Solid Films 491 2005 264 [16] J.B. Peng N. Takada N. Minami Thin Solid Films 405 2002 224 [17] M.X. Zhu Z.L. Wu C.Y. Jiang J. Liu J.R. Li K.Q. Xing Y.P. Yang Q. Gan Y. Cao W.G. Zhu Chin. Phys. Lett. 22 7 2005 1793 [18] Z.L. Wu M.X. Zhu Y. Liu J. Liu J.R. Li Y.P. Yang Q. Gan W.G. Zhu Chin. Chem. Lett. 16 2 2005 241",
        "keywords": [
            "electroluminescence",
            "europium complex",
            "oxadiazole",
            "photoluminescence",
            "thermal stability",
            "full width at half maximum"
        ],
        "authors": [
            {
                "name": "Yu Liu",
                "org": "Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan 411105, PR China"
            },
            {
                "name": "Bo Liang",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Daili Xiao",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2009
    },
    "yfpRAEMv": {
        "id": "yfpRAEMv",
        "title": "Synthesis, Characterization and Photophysics of Fluorene-alt-Oxadiazole Copolymers Containing Pendent Iridium (III) Complex Moiety",
        "abstract": "A series of fluorene-alt-oxadiazole copolymers containing a pendent phosphor chromophore of the (piq) 2 Ir(pic) complex were synthesized via the palladium-catalyzed Suzuki coupling reaction, where piq is 1-phenylisoquinoline and pic is picolinic acid. These copolymers exhibited a similar absorption spectrum with a peak at about 330 nm and a typical emission peak at 408 nm in CH 2 Cl 2 from the fluorene-alt-oxadiazole backbone. However, a significantly red-shifted emission peak at about 625 nm was observed in the neat films of these copolymers, which are attributed to the pendent iridium (III) complex unit. Using these copolymers as single emission layer, the polymer light-emitting devices with a configuration of ITO/ PEDOT:PSS/copolymers/LiF/Al exhibited a saturated red emission with a peak at 632 nm. Significant influence of the attached iridium (III) complex ratio on EL performance was presented. A maximum current efficiency of 1.2 cd/A at 63 mA/cm 2 and a maximum luminance of 1125 cd/m 2 at 12 V were achieved from the device with the copolymer containing iridium (III) complex in a 3% molar ratio.",
        "keywords": [
            "polyfluorene",
            "copolymers",
            "electroluminescence",
            "iridium (iii) complex",
            "oxadiazole",
            "spectrum"
        ],
        "authors": [
            {
                "name": "jiyong deng",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "yu liu",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "yafei wang",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "hua tan",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "zhiyong zhang",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "gangtie lei",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "junting yu",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "meixiang zhu",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "weiguo zhu",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "yong cao",
                "org": "south china university of technology"
            }
        ],
        "venue": "European Polymer Journal",
        "year": 2011
    },
    "6vGbOBKK": {
        "id": "6vGbOBKK",
        "title": "Tuning photovoltaic performance of 9,9-dioctylfluorene-alt-5,7- bis(thiophen-2-yl)-2,3-biphenylthieno[3,4-b]pyrazine copolymeric derivatives by attaching additional donor units in pendant phenyl ring",
        "abstract": "A class of the 9,9-dioctylfluorene-alt-5,7-bis(thiophen-2-yl)-2,3- biphenylthieno [3,4-b]pyrazine copolymeric derivatives (PFO-3ThPz-D) attaching additional donor (D) units in the pendant phenyl ring with a D-A D structure was synthesized and investigated, where the additional D unit is a substituent group of fluorene, carbazole, and triphenylamine (Tpa). Their photovoltaic properties were significantly tuned by these pending donor units. Among these copolymers, the PFO-3ThPz-Tpa exhibited the best photovoltaic properties in the bulk heterojunction polymeric solar cells (BHJ-PSC). The maximum power conversion efficiency (PCE) of 2.09% and the highest circuit current density (J sc) of 7.91 mA/cm 2 were obtained in the cell using a blend of PFO-3ThPz-Tpa and PC 60BM (1:3, w/w) as active layer, which are 2.5 and 1.8 times higher than those corresponding levels in the other cell using the parent PFO-3ThPz-Ph copolymer instead of PFO-3ThPz-Tpa as donor, respectively. While PC 60BM was replaced by PC 70BM, the PFO-3ThPz-Tpa-based BHJ-PSC exhibited better photovoltaic properties with PCE of 3.08% and J sc of 10.3 mA/cm 2. This work demonstrated that attaching donor units into the D-A-based copolymeric side-chain is a simple and effective method to improve the photovoltaic properties for the resulting copolymers. Copyright \u00a9 2012 Wiley Periodicals, Inc.",
        "keywords": [
            "dioctylfluorene-alt- 5",
            "7-bis(thiophen-2-yl)-2",
            "3- biphenylthieno[3",
            "4-b]pyrazine copolymers",
            "functionalization of polymers",
            "high-performance polymer",
            "polymer solar cells",
            "synthesis"
        ],
        "authors": [
            {
                "name": "Jianmin Li",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Xianping Deng",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Zhiyong Zhang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yafei Wang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yu Liu,",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Keqi He",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Ying Huang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Qiang Tao",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Lixia Quan",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "Journal of Polymer Science, Part A: Polymer Chemistry",
        "year": 2012
    },
    "72YHHF4j": {
        "id": "72YHHF4j",
        "title": "Synthesis and opto-electronic properties of a red-emitting heteroleptic platinum complex using pyrazol-based diketone derivative as ancillary ligand",
        "abstract": "A red-emitting heteroleptic cyclometalated platinum(II) complex containing an ancillary ligand of pyrazol-based diketone derivative was synthesized. Its optophysical and electroluminescent properties were studied. Compared to the reported (piq)Pt(acac) complex, this platinum(II) complex exhibited a blue-shifted UV absorption band at 300-450 nm, a low LUMO energy level and improved electroluminescent property. Using this platinum(II) complex as a single doping emitter and a blend of ploy(9,9-dioctylfluorene) and 2-tert-butylphenyl-5-phenyl- 1,3,4-oxadiazole as a host matrix, the fabricated polymer light-emitting devices displayed saturated red emission with a peak at 648 nm and a shoulder at 601 nm. Furthermore, the emission quenching of the platinum(II) complex was significantly suppressed in these devices at high current density due to an introduction of the non-planar pyrazol group into the ancillary ligand. \u00a9 2011 SIOC, CAS, Shanghai, & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",
        "keywords": [
            "electroluminescence",
            "molecular device",
            "optoelectronic properties",
            "platinum(ii) complex",
            "synthesis design"
        ],
        "authors": [
            {
                "name": "Jiyong Deng",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yafei Wang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Xiaoshuang Li",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Meijun Ni",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Ming Liu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yu Liu,",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Gangtie Lei",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "Chinese Journal of Chemistry",
        "year": 2011
    },
    "YkoteYKs": {
        "id": "YkoteYKs",
        "title": "Synthesis and photovoltaic performance of <Emphasis Type=\"Italic\">N</Emphasis>-dioctylmethyl-2,7-carbazole-<Emphasis Type=\"Italic\">alt</Emphasis>-5,7-bis(thiophen-2-yl)-2,3-biphenylthieno[3,4-b] pyrazine copolymeric derivatives appending various donor units in phenyl moieties",
        "abstract": "A series of N-dioctylmethyl-2,7-carbazole-alt-5,7-bis(thiophen-2-yl)-2,3-biphenylthieno[3,4-b]pyrazine (PCz-3ThPz-Ph) copolymeric derivatives appending various donor units in two phenyl rings, namely, PCz-3ThPz-PhTh, PCz-3ThPz-PhFl, PCz-3ThPz-PhCz, and PCz-3ThPz-PhTpa were synthesized and characterized. The effect of these appending donor units, e.g., thiophene (Th), fluorine (Fl), carbazole (Cz), and triarylamine (Tpa), was investigated on dispersible, optical, electrochemical, and photovoltaic properties for their polymers. The copolymers of PCz-3ThPz-PhCz and PCz-3ThPz-PhTpa containing Cz or Tpa units exhibited higher short-circuit current density (J sc) and power conversion efficiency (PCE) in their bulk heterojunction polymeric solar cells. The highest PCE of 1.66% and J sc of 7.16 mA cm\u22122 were obtained in a device with the PCz-3ThPz-PhCz/PC61BM blend under AM 1.5 G irradiation (100 mW cm\u22122); these values are 1.78 and 1.59 times higher than the corresponding values for the PCz-3ThPz-Ph-based device. When PC61BM was placed by PC71BM, the PCz-3ThPz-PhCz-based device displayed an enhanced PCE of 2.98% and a J sc of 10.88 mA cm\u22122. This work demonstrated that appending additional hole-transporting units of Cz and Tpa into the side-chain of a polymer with a D-A backbone can significantly enhance the photovoltaic performance of their resultant polymers.",
        "keywords": [
            "conjugated polymers",
            " polymer solar cells",
            " thieno[3",
            "4-b]pyrazine",
            " functionalization of polymers"
        ],
        "authors": [
            {
                "name": "Jianmin\u00a0Li",
                "org": "Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, College of Chemistry,Xiangtan University,Xiangtan,China"
            },
            {
                "name": "Hua\u00a0Tan",
                "org": "Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, College of Chemistry,Xiangtan University,Xiangtan,China"
            },
            {
                "name": "Fanyuan\u00a0Meng",
                "org": "Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, College of Chemistry,Xiangtan University,Xiangtan,China"
            },
            {
                "name": "Wenhong\u00a0Peng",
                "org": "Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, College of Chemistry,Xiangtan University,Xiangtan,China"
            },
            {
                "name": "Yafei\u00a0Wang",
                "org": "Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, College of Chemistry,Xiangtan University,Xiangtan,China"
            },
            {
                "name": "Yu\u00a0Liu",
                "org": "Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, College of Chemistry,Xiangtan University,Xiangtan,China"
            },
            {
                "name": "Weiguo\u00a0Zhu",
                "org": "Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, College of Chemistry,Xiangtan University,Xiangtan,China"
            }
        ],
        "venue": "Science China Chemistry",
        "year": 2015
    },
    "fe9KxYPt": {
        "id": "fe9KxYPt",
        "title": "Synthesis, photo- and electroluminescence properties of asymmetrical alternating copoly(p-phenylenevinylene) derivatives",
        "abstract": "A series of asymmetrical alternating copoly( p -phenylenevinylene) derivatives (PPVs), poly(2-methoxy-5-alkoxy)-1,4-(phenylene vinylene)-alt-1,4-(phenylene vinylene), have been successfully synthesized via the Wittig polycondensation reaction as potential electroluminescent (EL) materials. These copolymers contain two components, one is phenylene vinylene with asymmetrical flexible side chain to improve the solubility of the copolymer in common solvents and to suppress its crystallization; the other is a rigid phenylene vinylene moiety to improve the luminescent quantum efficiency and the thermal stability. The photoluminescent (PL) properties and thermal behavior of these copolymers have been investigated in detail. The results showed that the PL intensity increased but the thermal stability decreased with increasing side chain length. A double-layer device of ITO/PEDOT\u2013PSS/Polymer 3/Ba/Al showed a greenish yellow emission peaking at 548 nm with a turn-on voltage as low as 6.2 V. A maximum brightness of 534 cd/m 2 was obtained at a driving voltage of 10 V. PACS 78.60.Fi Keywords Copoly( p -phenylenevinylene) derivatives Wittig polycondensation Photoluminescence Electroluminescence 1 Introduction Polymers with \u03c0-conjugation have been the subject of both theoretical and experimental research for the past few decades owing to their important and useful potential properties such as conductivity, electroluminescence, optical nonlinearity, etc. [1\u20133] . Poly( p -phenylenevinylene) and its derivatives (PPVs) are considered as potential electroluminescent materials due to the low driving voltages, high efficiency, and reasonably good environmental stability. PPV derivatives with alkoxy side chains, such as poly[2-methoxy-5-(2-ethylhexyloxy)- p -phenylenevinylene] (MEH-PPV), are soluble in common solvents and easy to fabricate EL device by spin-coating. Many derivatives of PPV have been investigated to enhance the efficiency of LEDs or change the emitting color [4\u20137] . For PPV derivatives, the emission color can be tuned either by introduction of different \u03c0-conjugated links, or by inclusion of nonconjugated carbon bridges along the polymer backbone. The solubility of polymers is adjusted by attaching long side chains onto the polymer backbone. More recently, some new methods for preparing novel and high quality PPV derivatives have been reported [8] , Liao and coworkers achieved a blue-emitting PPV derivative with a high content of trans -CH CH\u2013 linkages [9] . Wang et al. synthesized a red-emitting PPV copolymer by introducing dipyridine into the PPV backbone [10] . In this contribution, we design a series of PPV derivatives based on alternating copolymers with different side chain lengths. The synthetic details of the asymmetrical alternating PPVs and their photo- and electroluminescence properties were reported. The effects of the side chain length on the morphology, thermal stability and absorption and emission spectra of the copolymers have also been investigated. Such information is believed to be useful for the preparation of electroluminescent materials and the design of LED device structures. 2 Experimental 2.1 Materials Terephthaldicarboxaldehyde, triphenyl phosphine, alkyl bromide were purchased from Acros and Shanghai Medical Company (China), respectively. All of the solvents are analytical-grade quality, purchased commercially and dried over MgSO 4 and redistilled before use and stored with a 5 \u00c5 molecular-sieve. 2.2 Measurements The elemental analysis of all monomers and polymers were performed with a Perkin\u2013Elmer 2400 analyzer for C, H determination. The FT-IR spectra were obtained on a Perkin\u2013Elmer Spectrum One Fourier transform infrared spectrometer (KBr pellet). 1 H NMR spectra were recorded on a Bruker NMR400 spectrometer operating at 400 MHz and deuterated chloroform was used as the solvent, and tetramethylsilane (TMS) was used as the internal standard. Ultraviolet\u2013visible (UV\u2013Vis) spectra were measured with a Lambda 25 spectrophotometer. The fluorescence spectra were conducted on a Perkin\u2013Elmer LS55 luminescence spectrometer with a xenon lamp as the light source. Gel permeation chromatography (GPC) analysis was carried out by using a Waters 1515 Isocratic HPLC system equipped with a differential refractive index detector, Waters column Heater Module as a separate column, and an Ultrastyragel linera column at 35 \u00b0C using (HPLC grade) tetrahydrafuran (THF) as the eluant. The molecular weight and the molecular weight distribution were calculated on the basis of monodispersed polystyrene standards. Differential scanning calorimetry (DSC) of the polymer powders and thermogravimetric analysis (TGA) were conducted under nitrogen at a heating rate 10 K/min with a Perkin\u2013Elmer DSC-7 thermal analyzer and a Shimadzu TGA-7, respectively. The quantum yields of fluorescence were determined in deoxygenated chloroform against quinine sulfate in 0.5 mol/L H 2 SO 4 assuming a quantum yield of 0.546. 2.3 EL device fabrication and characterization The EL device was constructed using a double-layer structure with poly(3,4-ethylenedioxythiophene) (PEDOT):poly(styrene sulfonic acid) (PSS) as the hole transporting layer and the copolymer as the emitting layer. ITO (indium\u2013tin-oxide)-coated glass (15 \u03a9/m 2 ) as an anode was patterned by an aqua regia solution (HCl:HNO 3 = 3:1). The patterned ITO-coated glass was sonicated in a detergent solution followed by trichloroethylene and isopropyl alcohol, deionized water and dipped into acetone in order. After that, ITO-coated glass was dried by high purity N 2 and exposed to UV O 3 for 10 min PEDOT:PSS was spin-coated onto ITO and the thickness of the film was determined by the Alpha-step 500 surface profiler (Tencor), The PEDOT:PSS layer was dried in a vacuum oven at 80 \u00b0C for 1 h. The copolymer was then spin-coated from a toluene solution and the thickness was 70 nm. Ba (barium) metal was thermally evaporated onto the top of the active layer and finally a 150 nm thick aluminum layer was thermally evaporated onto the top of the Ba layer. The deposition rates and the thickness of the evaporation layers were monitored by a thick/rate meter Model STM-100 (sycon). The deposition rates were usually 0.5\u20131 nm/s. The size of the active area of the cathode area was 0.15 cm 2 . With the exception of spin-casting a PEDOT:PSS layer, all the fabrication steps were carried out in a nitrogen glove box. The current\u2013voltage\u2013brightness characteristics of the device were measured in a Keilthley 236 source measure unit. EL efficiency and brightness were carried out with a calibrated silicon photodiode. EL spectrum was recorded on an Instaspec 4 CCD spectrophotometer (Oriel Co.). Evaluation of the EL device was performed under ambient conditions. 2.4 Synthesis of monomers and polymers Synthetic routes of the monomers and polymers are shown in Scheme 1 . 2.4.1 2-Methoxy-5- n -butoxy benzene (2a) 4-Methoxyphenol (0.08 mol) and a freshly prepared sodium methoxide (equiv) were dissolved in 50 mL methanol under nitrogen atmosphere. The solution was refluxed for 1 h and cooled to the room temperature. n -Butyl bromide (0.073 mol) was dropped into the reaction solution. The mixture was refluxed for 5 h under ultrasonic wave. Then it was poured into plenty of water after being cooled to room temperature. The crude product was washed several times with water and sodium carbonate then recrystallized from isopropanol. After filtration and drying in a vacuum oven, a white pastelike crystal was obtained in 92% yield, mp: 25.5\u201327.0 \u00b0C. IR (KBr, cm \u22121 ): 2945, 2985, 1243, 1205, 1035, 827. 1 H NMR (CDCl 3, TMS) \u03b4 (ppm): 0.92\u20131.00 (t, 3H), 1.40\u20131.55 (m, 2H), 1.68\u20131.79 (m, 2H), 3.66 (s, 3H), 3.75\u20133.8 (t, 2H), 6.76 (s, 4H). Anal. Calcd for C 11 H 16 O 2 : C, 73.29; H, 8.95. Found: C, 73.11; H, 8.90. 2.4.2 2-Methoxy-5-n-pentoxy benzene (2b) Compound 2b was prepared according to the procedure described in 2a except that pentyl bromide was used instead of n -butyl bromide. Yield: 90%, mp: 27\u201328.5 \u00b0C. IR (KBr, cm \u22121 ): 3020, 2940, 2843, 1242, 1208, 1037, 830, 534. 1 H NMR (CDCl 3, TMS) \u03b4 (ppm): 0.91 (t, 3H), 1.28\u20131.35 (m, 6H), 3.63 (s, 3H), 3.75\u20133.76 (t, 2H), 6.72 (s, 4H). Anal. Calcd for C 12 H 18 O 2 : C, 74.19; H, 9.34. Found: C, 74.22; H, 9.25. 2.4.3 2-Methoxy-5-octoxy benzene (2c) Compound 2c was prepared according to the procedure described in 2a except that octyl bromide was used instead of n -butyl bromide. Yield: 87%, mp: 32.5\u201335 \u00b0C. IR (KBr, cm \u22121 ): 2932, 1512, 1293, 1243, 1036, 827. 1 H NMR (CDCl 3, TMS) \u03b4 (ppm): 0.86 (t, 3H), 1.30\u20131.42 (m, 12H), 3.62 (s, 3H), 3.80 (t, 2H), 6.71 (s, 4H). Anal. Calcd for C 15 H 24 O 2 : C, 76.23; H, 10.23. Found: C, 76.12; H, 10.25. 2.4.4 1,4-Bis(chloromethyl)-2-methoxy-5-butoxy benzene (3a) To a mixture of 2a (0.02 mol), 1,4-dioxane (40 mL), paraformaldehyde (0.025 mol), formaldehyde (36%, 6 mL), concentrated HCl (100 mL) were added to the round flask. The solution was refluxed for 6 h. After cooling, the white crude product was filtered and washed several times with water and sodium hydrocarbonate solution. The crude solid was dissolved in a small amount of hexane and then carefully poured into excess methanol. After filtration and drying in a vacuum oven, a white needle-like solid was obtained. Yield: 82%; mp: 74\u201375.5 \u00b0C. IR (KBr, cm \u22121 ): 3025, 2936, 1516, 1465, 1414, 1227, 1030, 875, 732, 693. 1 H NMR (CDCl 3, TMS) \u03b4 (ppm): 0.60\u20131.00 (t, 3H), 1.40\u20131.56 (m, 2H), 1.64\u20131.80 (m, 2H), 3.84 (s, 3H), 3.90\u20134.06 (t, 2H), 4.63 (s, 4H), 6.91 (s, 2H). Anal. Calcd for C 13 H 18 O 2 Cl 2 : C, 56.33; H, 6.55. Found: C, 56.21; H, 6.47. 2.4.5 1,4-Bis(chloromethyl)-2-methoxy-5-pentoxy benzene (3b) Yield: 76%; mp: 82.5\u201385 \u00b0C. IR (KBr, cm \u22121 ): 2931, 1517, 1414, 1230, 1020, 873, 734, 690, 611. 1 H NMR (CDCl 3, TMS) \u03b4 (ppm): 0.81\u20131.02 (t, 3H), 3.92\u20134.01 (t, 2H), 4.70 (s, 4H), 6.92 (s, 2H), 3.90\u20133.94 (s, 3H), 1.60\u20131.82 (m, 6H), 0.70\u20130.95 (t, 3H). Anal. Calcd for C 14 H 20 O 2 Cl 2 : C, 57.74; H, 6.92. Found: C, 57.70; H, 6.58. 2.4.6 1,4-Bis(chloromethyl)-2-methoxy-5-octoxy benzene (3c) Yield: 76%; mp: 66\u201368.5 \u00b0C. IR (KBr, cm \u22121 ): 3020, 2931, 1517, 1415, 1263, 1230, 1028, 874, 734, 690, 611. 1 H NMR (CDCl 3, TMS) \u03b4 (ppm): 0.98 (t, 3H), 1.40 (m, 4H), 1.60 (m, 6H), 1.86 (m, 2H), 3.92 (s, 3H), 4.08 (t, 2H), 4.72 (s, 4H), 7.00 (s, 2H). Anal. Calcd for C 17 H 26 O 2 Cl 2 : C, 61.26; H, 7.86. Found: C, 61.23; H, 7.92. 2.4.7 2-Methoxy-5-butoxy-1,4-xylenebis(triphenyl phosphonium chloride) (4a) This was synthesized by an adapted literature procedure [11] . A mixture of compound (3a) (0.003 mol), triphenyl phosphine (0.009 mol) and 10 mL of freshly distilled DMF was heated to 95 \u00b0C while stirring for 24 h. The resultant mixture was dropped into diethyl ether, and then stirred. The white solid was filtered, washed repeatedly with diethyl ether to remove the by-products, and dried then under high vaccum to give a white powder 4a. Yield: 85%, mp: >200 \u00b0C. IR (KBr, cm \u22121 ): 3043, 1580, 1512, 1439, 1222, 1111, 1020, 996, 878, 753, 695, 536, 490. 1 H NMR (CDCl 3, TMS) \u03b4 (ppm): 7.80\u20137.54 (m, 30H), 6.82 (s, 1H), 6.79 (s, 1H), 5.27 (s, 2H), 5.16 (s, 2H), 2.97\u20132.93 (t, 2H), 2.76 (s, 3H), 1.25\u20130.97 (m, 4H), 0.78 (t, 3H). Anal. Calcd for C 49 H 48 O 2 P 2 Cl 2 : C, 73.40; H, 6.03. Found: C, 73.12; H, 5.98. 2.4.8 2-Methoxy-5-pentoxy-1,4-xylenebis(triphenyl phosphonium chloride) (4b) This was synthesized according to the procedure described in 4a, Yield: 82%, mp: >200 \u00b0C. IR (KBr, cm \u22121 ): 3021, 2946, 1674, 1441, 1388, 1233, 1110, 995, 876, 829, 756, 692, 527, 490. 1 H NMR (CDCl 3, TMS) \u03b4 (ppm): 7.75\u20137.63 (m, 30H), 6.81 (s, 1H), 6.8 (s, 1H), 5.35 (s, 2H), 5.31 (s, 2H), 3.03\u20133.06 (t, 2H), 2.89 (s, 3H), 1.06\u20131.20 (m, 6H), 0.84\u20130.89 (t, 3H). Anal. Calcd for C 50 H 50 O 2 P 2 Cl 2 : C, 73.61; H, 6.18. Found: C, 73.59; H, 6.12. 2.4.9 2-Methoxy-5-octoxyl-1,4-xylenebis(triphenyl phosphonium chloride) (4c) Yield: 78%, mp: >200 \u00b0C. IR (KBr, cm \u22121 ): 3020, 2925, 2854, 1586, 1513, 1437, 1223, 1111, 1027, 965, 874, 745, 690, 528, 491. 1 H NMR (CDCl 3, TMS) \u03b4 (ppm): 7.86\u20137.57 (m, 30H), 6.78 (s, 1H), 6.54 (s, 1H), 5.12 (s, 1H), 4.97 (s, 2H), 3.04\u20133.12 (t, 2H), 2.80 (s, 3H), 1.30\u20130.97 (m, 12H), 0.85\u20130.83 (t, 3H). Anal. Calcd for C 53 H 56 O 2 P 2 Cl 2 : C, 74.20; H, 6.58. Found: C, 74.15; H, 6.53. 2.4.10 Polymerization The polymers were synthesized by using Wittig polycondensation [12] . 1 mmol of 2-methoxy-5-alkyloxy-1,4-xylenebis(triphenyl phosphonium chloride) and 1 mmol of terephthalaldehyde were dissolved in 10 mL chloroform. A mixture of ethanol (10 mL) and sodium methoxide (6 mmol) was added carefully dropwise into the reaction flask at room temperature. An orange\u2013yellow solution was formed. After the reaction mixture was stirred for another 24 h at room temperature, 1 mL of 0.1 mol/L aqueous HCl solution was added to the reaction flask. The resulting polymer was precipitated with methanol. The crude product was filtered and then purified by using a Soxhlet extractor in methanol and water (90/10) for 24 h, subsequently dried under vacuum at 40 \u00b0C to give a yellowish polymer. Yield: 65%. IR (KBr, cm \u22121 ): 2934, 2862, 1492, 1206, 1002, 963, 849. Anal. Calcd for (C 19 H 20 O 2 ) n : C, 81.40; H, 7.19. Found: C, 81.03; H, 7.05. Other polymers (polymer 2 and polymer 3) were synthesized, purified and characterized in a similar method as polymer 1. For polymer 2, yield: 62%. IR (KBr, cm \u22121 ): 2930, 2828, 1598, 1492, 1208, 1006, 963, 852. Anal. Calcd for (C 20 H 22 O 2 ) n : C, 81.60; H, 7.53. Found: C, 81.13; H, 7.35. For polymer 2, yield: 53%. IR (KBr, cm \u22121 ): 2932, 2834, 1589, 1497, 1201, 1008, 964, 843. Anal. Calcd for (C 23 H 28 O 2 ) n : C, 82.10; H, 8.39. Found: C, 82.73; H, 8.55. 3 Results and discussion 3.1 Synthesis and characterization The synthetic route for the asymmetrical alternating copolymers is shown in Scheme 1 . All steps are facile and can be well controlled. Monomers 4(a\u2013c) were prepared in three steps from 4-methoxyphenol through the Williamson reaction using sodium methoxide and alkyl bromide in methanol, and converted to 2(a\u2013c). The intermediates 3(a\u2013c) were obtained by adding concentrated HCl and paraformaldehyde in 1,4-dioxane. The reaction of 3(a\u2013c) with triphenyl phosphine in DMF led to the triphenylphosphonium salt 4(a\u2013c) in high yields. Polycondensation of the corresponding comonomers gave the polymers 5(a\u2013c). The monomer and polymer structures were shown to be consistent with the elemental analysis and spectroscopic data from 1 H NMR and FT-IR. Fig. 1 shows the FT-IR spectra of the comonomers and polymer 1. The characteristic peak at 995 cm \u22121 corresponds to the C\u2013P stretching vibration of the triphenyl phosphonium group (4a) and the strong absorption peak at 1693 cm \u22121 corresponds to the C O stretching vibration of terephthaldehyde, respectively. However, these absorption peaks decreased drastically after polymerization in polymer 1. Meanwhile, a weak but sharp absorption peak at 963 cm \u22121 corresponding to the out-of-plane bending mode of the trans -vinylene group appeared, suggesting that the double bonds generated are mainly in the trans configuration. The 1 H NMR signals in the olefinic regions appear at \u03b4 of about 7.1\u20137.3 ppm, typical for trans -stilbene moieties, and also \u03b4 at about 6.6\u20136.8 ppm, attributable to the cis -isomer. The obtained polymers were highly soluble in common organic solvents such as chloroform, methylene chloride, 1,1,2,2-tetrachloroethane and tetrahydrofuran, although they were insoluble in hexane and methanol. It is speculated that the asymmetrical structure and flexible side chain in the rigid p -phenylenevinylene backbone significantly enhances the solubility. The number-average molecular weight ( M n ) and the weight-average molecular weight ( M w ) of the polymers, as determined by gel permeation chromatography using polystyrene standards, are also shown in Table 1 . The average molecular weight is in the range of 2800\u20133500 for the M n and 7000\u201310 000 for the M w with a polydispersity index of 2\u20133. The average molecular weight of these polymers is rather low indicating that the reaction is rather slow and that the formed oligomers probably become less and less reactive during polymer chains growth until they eventually precipitate [13,14] . Optimization of the reaction conditions and alternative synthetic routes are under further investigation. 3.2 Thermal analysis Table 1 lists the thermal analysis data of three polymers. TGA and DSC thermograms are shown in Fig. 2 . A glass transition temperature ( T g ) at 93 \u00b0C for polymer 1 and 74 \u00b0C for polymer 2 can be detected by using DSC. It implied that the copolymers with the shorter alkoxy chain exhibited clear endothermic peaks at the glass transition temperature. When the length of the alkoxy chain is increased to eight carbon atoms, the glass transition peak of polymer 3 became undetectable. As shown in Table 1 , the T g decreased with increasing alkoxy chain length. The dependence of T g on the length of the alkoxy substituent is interpreted in terms of the steric effect of alkoxy chains [15] . Moreover, it is shown in the TGA curves and T d values in Table 1 , that these polymers possess different thermal properties. The thermal stability decreased with increasing side chain length. None of the polymers showed distinct melting points, indicating that the polymers are amorphous. 3.3 Optical properties Table 2 summarizes the optical properties of the polymers. The UV spectra of the polymers in Fig. 3 show that the absorption spectra of the three polymers are similar in shape, with the peak of the \u03c0\u2013\u03c0 \u2217 absorption band occurring between 460 nm (2.70 eV) and 480 nm (2.58 eV). The difference is that the longer the side chains, the greater the sterical hindrance. The steric effect made the backbone of PPV rotate, consequently the effective conjugation length reduced and caused an absorption and emission blueshift in dilute solution. The octoxyl group is the longest side chain of the three polymers, so the absorption wavelength of polymer 3 blueshifted more compared to that of polymer 1 and polymer 2. The absorption intensities of three polymers with the same concentration were different, which may be related to the molecular weight. Furthermore, the \u03bb max in chloroform solution shows bathochromic shifts compared to those in the solid film state. This positive solvatochromism could be attributable to the much greater solvation stabilization in the excited state compared with the ground state [16] . Meanwhile, the absorption band is broader in the solid state than in the solution, which means that there are more energy levels in the solid state corresponding to the \u03c0\u2013\u03c0 \u2217 transition for the polymers. Furthermore, Table 2 listed the PL quantum efficiency and the band gap, PL quantum efficiency is in the range of 0.17\u20130.33, polymer 3 shows the highest quantum efficiency of 0.33. The band gap of the polymers is 2.24\u20132.33 eV, among the polymers, polymer 3 possesses the highest quantum efficiency and the largest band gap, which may be concerned with the long alkoxy chain length. Photoluminescence (PL) spectra of the polymer solutions and films were shown in Fig. 4 . The polymer solutions exhibited similar emissions in the range of 510\u2013560 nm when they were excited with the corresponding maximum excitation wavelength as shown in Fig. 4 (a). PL intensity increased with increasing side chain length. This implies that the long alkoxy chain can diminish concentration quenching when the polymers are in the same states. As a result, polymer 3 exhibits the strongest emission among the three polymers. The PL spectra of polymer films show broad peaks and are redshifted in comparison to those of the polymer solutions. The maximum emission peaking of the solid polymer films compared to the UV absorption spectra showed redshifts of about 130 nm. As shown in Fig. 4 (b), the spectra width and featureless nature of the solid films, combined with these large shifts, suggest that interchain interactions have an important effect on the excited state emission mechanisms of polymers. Usually, \u03c0\u2013\u03c0 \u2217 interactions or aggregation of \u03c0-conjugated polymer chains in the solid state leads to a redshift in the emission spectrum relative to the solution phase. 3.4 Electroluminescence properties In order to investigate the electroluminescent properties of the polymers, a double-layer device, ITO/PEDOT\u2013PSS/Polymer 3/Ba/Al, was fabricated and evaluated in the configuration. The PEDOT\u2013PSS was used as a hole transporting layer; polymer 3 was used as the emitting layer and a thin layer of Ba (4 nm) was used as the cathode. The Ba layer was coated with a 150 nm layer of Al. The thickness of the emissive layer was about 70 nm. The EL spectrum from such a device is shown in Fig. 5 . The typical current\u2013voltage\u2013brightness characteristics of the device are presented in Fig. 6 . The current\u2013voltage\u2013brightness curves of the device displayed an excellent diode behavior, i.e. under the forward bias, the current and the intensity of the emitting light increased superlinearly with the increase of applied voltage after surpassing the turn-on voltage of 6.2 V. Moreover, under reverse bias, no obvious increase in the current was observed when the applied voltage increased, and luminescence starts at a voltage as low as 6.2 V. The maximum luminance of 534 cd/m 2 was obtained at 10 V and the external quantum efficiency was 0.04%. The luminescence efficiency can reach \u03b7 = 0.025 lm/W according to the equation \u03b7 = \u03c0 SB / VI where \u03b7 is EL efficiency (lm/W), S emissive area (m 2 ), B luminance (cd/m 2 ), V voltage (V) and I current (A). The EL spectrum of the device based on polymer 3 shows an emission peak at 548 nm in the greenish yellow region. Remarkably, the maximum emissive wavelength is between the peaks of the PL spectra of its solution and that of its film sample. The shape is similar to the PL emission of the solid film but with a small hypsochromic shift. This indicates the same singlet excitons being responsible for both the EL and PL emissions. The spectra are little changed at different current densities, indicative of the good stability of the EL devices. It should be noted that the present work has not attempted to modify the configurations and fabrication conditions of the devices. After the optimization of such parameters, a higher emission efficiency is expected. 4 Conclusions A series of asymmetrical alternating PPVs with different side chain lengths were prepared through Wittig polycondensation reactions in high yields. The synthesized polymers are readily soluble in common organic solvents, which can simplify device fabrication and processing. The solutions and films of these polymers can emit very strong green\u2013yellow light with the excitation of the visible light, and the intensity of the fluorescence in solution increased with increasing length of the asymmetrical side chain. The amorphous conjugated polymers showed high glass transition temperatures and good thermal stability. A double-layer LED, ITO/PEDOT\u2013PSS/Polymer 3/Ba/Al, showed bright greenish yellow emission at 548 nm, with a low turn-on voltage of 6.2 V. A maximum brightness of 534 cd/m 2 can be obtained at a driving voltage of 10 V. Acknowledgement This work was supported by the National Nature Science Foundation of China (50473045). References [1] J. Pei W.L. Yu W. Huang Alan A.J. Heeger Macromolecules 33 2000 2462 [2] S.W. Ko B.J. Jung T. Ahn H.K. Shim Macromolecules 35 2002 6217 [3] K.S. Narayan K.V. Geetha G. Nakmanovich E. Ehrenfreund Y. Eichen J. Phys. Chem. B 105 2001 7671 [4] C.C. Chiu K.F. An H.L. Chou J. Polym. Sci. Part A: Polym. Chem. 41 2003 2180 [5] T. Fujisawa R. Ootake Y. Nishihara A. Fuji K. Yoshino Jpn. J. Appl. Phys. 40 2001 474 [6] D. Xiang Q.D. Shen S. Zhang X.Q. Jiang J. Appl. Polym. Sci. 88 2003 1350 [7] Z. Hong D. Wang D. Ma X. Zhao X. Jing F. Wang Synth. Metal 91 1977 321 [8] X.F. Wu G.Q. Shi F.E. Chen S.H. Han J.B. Peng J. Polym. Sci. Part A: Polym. Chem. 42 2004 3049 [9] L. Liao Y. Pang L.M. Ding F.E. Karasz J. Polym. Sci. Part A: Polym. Chem. 41 2003 2650 [10] L.H. Wang Z.K. Chen Y. Xiao E.T. Kang W. Huang Molemol. Rapid. Commun. 21 2000 897 [11] M. Zheng L.M. Ding E.E. Gurel P.M. Lahti F.E. Karasz Macromolecules 34 2001 4124 [12] A.M. Sarker E.E. Gurel M. Zheng P.M. Lahti F.E. Karasz Macromolecules 34 2001 5897 [13] B.E. Maryanoff A.B. Reitz B.A. Duhl-Emswiler J. Am. Chem. Soc. 107 1985 217 [14] C.A. Restrepo H. Cano F. Mari C.A. Gonzalez Heteroatom. Chem. 8 1997 557 [15] M. Fukuda K. Sawada K. Yoshino J. Polym. Sci. Part A: Polym. Chem. 31 1993 2465 [16] C. Reichardt Solvents and Solvent Effects in Organic Chemistry 1988 VCH New York (Chapters 6 and 7) [17] J.N. Demas G.A. Crosby J. Phys. Chem. 75 1971 991",
        "keywords": [
            "copoly(p-phenylenevinylene) derivatives",
            "electroluminescence",
            "photoluminescence",
            "wittig polycondensation",
            "quantum efficiency",
            "double layer",
            "thermal stability"
        ],
        "authors": [
            {
                "name": "Songting Tan",
                "org": ""
            },
            {
                "name": "Yingping Zou",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Changyun Jiang",
                "org": "Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology, Guangzhou 510640, PR China"
            }
        ],
        "venue": "Optical Materials",
        "year": 2006
    },
    "vDvNrrXS": {
        "id": "vDvNrrXS",
        "title": "High-efficiency red electroluminescence from europium complex containing a neutral dipyrido(3,2-a:2\u2032,3\u2032-c)phenazine ligand in PLEDs",
        "abstract": "In order to obtain high-efficiency monochromatic red emission in polymer light-emitting devices, a tris(dibenzoylmethanato)(dipyrido(3,2-a:2\u2032, 3\u2032-c)phenazine) europium [Eu(DBM) 3(DPPZ)] doped single-emissive-layer devices were fabricated using a blend of poly(9,9-dioctyl-fluorence) and 2-tert-butyl-phenyl-5-biphenyl-1,3,4-oxadiazole as a host matrix by solution process. Significantly improved electro-luminescent properties with sharp red emission at 611.5 nm were displayed in the Eu(DBM) 3(DPPZ)-doped devices at dopant concentrations from 1 to 8 wt.%. The highest luminance up to 1783 cd/m 2 at 2 wt.% dopant concentration, as well as the maximum external quantum efficiency of 2.5% and current efficiency of 3.8 cd/A were obtained at 1 wt.% dopant concentration. \u00a9 2012 Elsevier B.V. All rights reserved.",
        "keywords": [
            "electroluminescence",
            "europium(iii) complex",
            "optophysical properties",
            "polymer light-emitting devices"
        ],
        "authors": [
            {
                "name": "Yu Liu,",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yafei Wang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Juan He",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Qingqing Mei",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Kai Chen",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Jiaojiao Cui",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Chun Li",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Junbiao Peng",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yong Cao",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            }
        ],
        "venue": "Organic Electronics: physics, materials, applications",
        "year": 2012
    },
    "ExCsqdPZ": {
        "id": "ExCsqdPZ",
        "title": "Conjugated and nonconjugated bipolar-transporting dinuclear europium(III) complexes involving triphenylamine and oxadiazole units: Synthesis, photophysical and electroluminescent properties",
        "abstract": "Two novel bipolar-transporting dinuclear europium(III) complexes incorporating both hole-transporting triphenylamine (TPA) and electron-transporting oxadiazole (OXD) units into the dual phenanthroline ligands were successfully synthesized and characterized by IR, elemental analysis, electrochemical, photophysical analysis, and thermogravimetric analysis, in which the OXD unit was attached onto TPA unit by conjugated and unconjugated linkages for the europium complex A and B, respectively. Compared with complex B, complex A exhibited higher thermal stability and quantum efficiency. A maximum brightness of 296.3 cd/m2 at voltage of 8.5 V was obtained in the complex A-doped devices with saturated red emission using a blend of poly(vinylcarbazole) and 2-(4-biphenyl)-5-(4-tert-butyl-phenyl)-1,3,4- oxadiazole as a host matrix, which is about two-times higher than that from the complex B-doped devices with the same configuration. To best of our knowledge, this is one of the best results based on the dinuclear europium(III) complexes by spin-casting method. \u00a9 2013 Elsevier Ltd. All rights reserved.",
        "keywords": [
            "bipolar-transporting",
            "dinuclear europium(iii) complexes",
            "electroluminescence",
            "polymer light-emitting devices",
            "synthesis"
        ],
        "authors": [
            {
                "name": "Yu Liu,",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Kai Chen",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Kongqiang Xing",
                "org": "Qionzhou College(Qionzhou College),,China"
            },
            {
                "name": "Yafei Wang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Haigang Jiang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Xiangping Deng",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "Tetrahedron",
        "year": 2013
    },
    "wYygvckY": {
        "id": "wYygvckY",
        "title": "Red electrophosphorescence from oxadiazoles-functionalized iridium complexes in polymer light-emitting devices",
        "abstract": "A type of oxadiazole-functionalized iridium complex is newly employed as red phosphor emitter in polymer light-emitting devices (PLEDs) using a blend of poly (9,9-dioctylfluorene)(PFO) and 2-tert-butylphenyl-5-biphenyl-1,3,4- oxadiazole (PBD) as a host matrix. The devices show bright red electrophosphorescence with dominant peaks at about 593 nm and shoulders at about 642 nm. The highest luminance efficiency of 3.3 cd/A at 9.3 V and maximum luminance of 2912 cd/m 2 at 14.0 V are achieved in the devices. At current density of 100 mA/cm 2, the devices still exhibit luminance efficiency of 2.2 cd/A and luminance of 2300 cd/m 2. This indicates that the oxadiazole-functionalized iridium complexes have improved optoelectronic properties in the devices at high current density. \u00a92006 Chinese Physical Society and IOP Publishing Ltd.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "ZhongLian Wu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "CuiPing Luo",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Zhengyong Hu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Changyun Jiang",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            },
            {
                "name": "FengLiang Huang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "KeMing Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2006
    },
    "vBQaa8eI": {
        "id": "vBQaa8eI",
        "title": "Improved blue-green electrophosphorescence from a tuning iridium complex with benzyl group in polymer light-emitting devices",
        "abstract": "Electroluminescence performances from a tuning biscyclometlated iridium complex with benzyl group are demonstrated in double-layered polymer light-emitting devices (PLEDs) using a blend of poly(9,9-dioctylfluorene) and 2-tert-butylphenyl-5-biphenyl-1,3,4-oxadiazole as a host matrix. Blue-green electrophosphorescent emission with a peak at 521 nm and a shoulder at 492 nm was observed. The highest luminance efficiency of 4.8 cd/A at current density of 0.56mA/cm 2 and a maximum luminance of 1944cd/m 2 at 217.6 mA/cm 2 were achieved in the devices at the dopant concentration of 8%. The luminous performance of the devices becomes better with increasing dopant concentrations from 1% to 8%. This implies that the concentration quenching of this iridium complex with benzyl group can be efficiently inhibited in the devices. \u00a9 2008 Chinese Physical Society and IOP Publishing Ltd.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Ma Xiao-Yun",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Zhu Ke-Ming",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Lei Wang",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            },
            {
                "name": "Fang Liang Xiao",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Wen Zhong-Lin",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Zhu Mei-Xiang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Zhu Wei-Guo",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2008
    },
    "QaXR76tr": {
        "id": "QaXR76tr",
        "title": "Synthesis and optoelectronic properties of oxadiazole-functionalized iridium complexes in the poly(vinylcarbazole)-hosted devices",
        "abstract": "A class of oxadiazole-functionalized iridium complexes was used as phosphor emitters in poly (vinylcarbazole)-hosted devices. Efficient green electrophosphorescences were achieved in the devices with a maximum luminance efficiency of 9.3\u00a0cd/A at 10.6\u00a0mA/cm 2 and brightness of 3882\u00a0cd/m 2 at 92.1\u00a0mA/cm 2 . More importantly, the iridium complexes-doped devices exhibited a low turn-on voltage of 7.0\u00a0V and an applied voltage of 9.2\u00a0V at 500\u00a0cd/m 2 . The good optoelectronic properties of the complexes were attributed to the enhanced electron-injection and transport properties resulting from the effect of oxadiazole ligands in the complexes.",
        "keywords": [
            "electrophosphorescence",
            "iridium complex",
            "photoluminescence",
            "oxadiazole",
            "optoelectronic device"
        ],
        "authors": [
            {
                "name": "Zhonglian Wu",
                "org": "IPOMD, South China University of Technology, Guangzhou 510640, China"
            },
            {
                "name": "Cuiping Luo",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Changyun Jiang",
                "org": "IPOMD, South China University of Technology, Guangzhou 510640, China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Yong Cao",
                "org": "IPOMD, South China University of Technology, Guangzhou 510640, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            }
        ],
        "venue": "Thin Solid Films",
        "year": 2008
    },
    "gmlVgnmy": {
        "id": "gmlVgnmy",
        "title": "Synthesis, photophysical and electrochemical characterization of the heteroleptic iridium complexes with modified ancillary ligand by carrier-transporting groups",
        "abstract": "Two heteroleptic iridium complexes with a general formulation of (piq) 2Ir(G-pic) were synthesized and characterized by 1H NMR, 13C NMR and element analysis, in which piq is 1-phenylisoquinoline, G-pic is picolinic acid derivative containing carrier-transporting group by a non-conjugated connection of 1,6-dioxyhexane. Both (piq)2Ir(G-pic) complexes exhibited an enhanced UV absorption band at 310-400 nm, an increased HOMO energy level and an identical red emission peaked at 612 nm with higher fluorescence quantum efficiency ( \u00d7 f), compared to (piq) 2Ir(pic) in dichloromethane solution. Interestingly, this iridium complex containing both hole-transporting triphenylamine and electron-transporting oxadiazole moieties exhibited the best f of 0.58 using Ru(bpy)3(PF6)2 as the reference ( \u00d7 f=0.062 in acetonitrile). This work indicates that incorporating carrier-transporting groups into ancillary ligand by a non-conjugated connection is available for improving the optophysical properties of their iridium complexes. Two functionalized phosphorescent iridium(III) complexes with carrier-transporting groups have been synthesized and characterized. Both of them exhibited a bright red emission at 612 nm with fluorescent quantum efficiency over 0.56 in dichloromethane. Compared to (Piq)2Ir(Pic), they presented better optophysical and electrochemical properties. \u00a9 2010 SIOC, CAS, Shanghai & WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",
        "keywords": [
            "1",
            "3",
            "4-oxadiazole",
            "bipolar-transporting",
            "iridium complex",
            "photophysics",
            "triphenylamine"
        ],
        "authors": [
            {
                "name": "Aihui Liang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yafei Wang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yu Liu,",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Hua Tan",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yunbo Cao",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Liang Li",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Xiaoshuang Li",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Wenjie Ma",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "Chinese Journal of Chemistry",
        "year": 2010
    },
    "WZKvfW4q": {
        "id": "WZKvfW4q",
        "title": "Study on DNA-binding and DNA-cleavage properties of Cr(III) complexes with polypyridyl ligands.",
        "abstract": "Two new water-soluble Cr(III) complexes [Cr(IP)(2)Cl(2)](+) and [Cr(PIP)(2)Cl(2)](+) (IP\u2009=\u2009imidazo[4,5-f][1,10]phenanthroline, PIP\u2009=\u20092-phenylimidazo[4,5-f][1,10]phenanthroline) were synthesized and characterized by elemental analysis, mass spectra, and ultraviolet-visible spectra. The DNA-binding properties of the two complexes were investigated by spectroscopic methods and viscosity measurements. The results indicate that both complexes bind to DNA via an intercalative mode with moderate strength. The fluorescence intensity of both complexes decreases with increasing DNA concentration, similar to those of [Cr(phen)(3)](3+) and [Cr(bpy)(3)](3+). Also, both complexes can cleave pBR-322 DNA in the presence of H(2)O(2), and [Cr(PIP)(2)Cl(2)](+) exhibits more effective activity than [Cr(IP)(2)Cl(2)](+) under the same condition.",
        "keywords": [],
        "authors": [
            {
                "name": "Xi-Ling Liang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Li-Feng Tan",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Wei-Guo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "DNA and cell biology",
        "year": 2011
    },
    "kClIgsWS": {
        "id": "kClIgsWS",
        "title": "Reduced-bandgap triphenylamine-alt-benzo[1,2-b:4,5-b\u2032]dithiophene copolymers pending benzothiadiazole or diketopyrrolopyrrole units for efficient polymer solar cells",
        "abstract": "Two new side-chain donor-acceptor (D-A)-based triphenylamine-alt-benzo[1,2- b:4,5-b\u2032]dithiophene (TPA-alt-BDT) copolymers (P1 and P2) with pendant benzothiadiazole (BT)/diketopyrrolopyrrole (DPP) in TPA unit were synthesized by Stille coupling polymerization. Their thermal, photophysical, electrochemical, blend film morphology and photovoltaic properties were investigated. Efficient bulk heterojunction polymer solar cells (PSCs) were obtained by solution process using both copolymers as donor materials and PC71BM as acceptor. The maximum power conversion efficiency (PCE) of 3.17% with a highest open-circuit voltage (Voc) of 0.86V was observed in the P1-based PSCs, while the maximum short-circuit current (Jsc) of 10.77 mA cm-2 was exhibited in the P2-based PSCs under the illumination of AM 1.5, 100 mW cm -2. The alternating binary donor units and pending acceptor groups played a significant role in tuning photovoltaic properties for this class of the side-chain D-A-based copolymers. \u00a9 2013 Wiley Periodicals, Inc.",
        "keywords": [
            "benzothiadiazole",
            "conjugated polymers",
            "diketopyrrolopyrrole",
            "high performance polymers",
            "morphology"
        ],
        "authors": [
            {
                "name": "Kaixuan Nie",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Hua Tan",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Xianping Deng",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yafei Wang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Qing Chen",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Ying Huang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yu Liu,",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Chuncheng Yang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Zhenrong Huang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "Journal of Polymer Science, Part A: Polymer Chemistry",
        "year": 2013
    },
    "4AS7iQD6": {
        "id": "4AS7iQD6",
        "title": "Highly efficient near-infrared emission from binuclear cyclo-metalated platinum complexes bridged with 5-(4-octyloxyphenyl)-1,3,4-oxadiazole-2-thiol in PLEDs",
        "abstract": "A novel near-infrared-emitting binuclear platinum complex of (piq) 2Pt 2(\u03bc-C 8OXT) 2 was synthesized and characterized, in which piq is 1-phenylisoquinolinato and C 8OXT is a bridging ancillary ligand of 5-(4-octyloxyphenyl)-1,3,4-oxadiazole)-2- thiol. Its optophysical, electrochemical and electroluminescent characteristics were primary studied. This binuclear platinum complex exhibited an intense UV absorption at about 493 nm from the metal-metal-to-ligand charge transfer transition and a bright near-infrared emission at 721 nm in chloromethane. Using (piq) 2Pt 2(\u03bc-C 8OXT) 2 as a single dopant, its single-emissive-layer polymer light-emitting devices presented a high-efficiency near-infrared emission peaked at 702 nm with the maximum external quantum efficiency of 6.3% at 7.6 mA cm -2. This work provides an efficient approach to realize high-efficiency near-infrared emission by binuclear platinum complexes. \u00a9 2012 Elsevier B.V. All rights reserved.",
        "keywords": [
            "binuclear platinum complexes",
            "electroluminescence",
            "near-infrared",
            "polymer light-emitting devices",
            "near infrared"
        ],
        "authors": [
            {
                "name": "Xiugang Wu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yu Liu,",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yafei Wang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Lei Wang",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            },
            {
                "name": "Hua Tan",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yong Cao",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            }
        ],
        "venue": "Organic Electronics: physics, materials, applications",
        "year": 2012
    },
    "vmsxual4": {
        "id": "vmsxual4",
        "title": "Highly dichroic metallomesogen of dinuclear platinum complex: Synthesis and liquid crystal and photophysical properties",
        "abstract": "A novel dinuclear platinum complex of (biC 12ppy-fl)Pt 2C 12DBM) 2 with liquid crystal luminescent property has been prepared, as well as its liquid crystal, optophysical properties and hole mobility have been studied, where biC 12ppy-fl is 6,6\u2032-[4,4\u2032-(9,9-didodecyl-9H-fluorene-2,7-diyl)bis(1,4-phenylene)] bis[3-(dodecyloxymethyl)pyridine] and C 12DBM is 1,3-bis[4- (dodecyloxy)phenyl]propane-1,3-dione. This dinuclear platinum complex displayed a smectic mesophase and excellent opto-physical properties. Compared to the reported mononuclear platinum complex of (C nROppy)Pt(acac) (R = H, F), this dinuclear platinum complex exhibited higher emission quantum yield and higher stability, as well as higher hole mobility of 8.4 \u00d7 10 -4 cm 2/(V s). Moreover, a highly polarized ratio of 10.3 was obtained for the aligned film of (biC 12ppy-fl)Pt 2(C 12DBM) 2 on the aligned polyimide at room temperature. \u00a9 2012 American Chemical Society.",
        "keywords": [],
        "authors": [
            {
                "name": "Yafei Wang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Qing Chen",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yanhu Li",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            },
            {
                "name": "Yu Liu,",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Hua Tan",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "JunTing Yu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Hongbin Wu",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yong Cao",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            }
        ],
        "venue": "Journal of Physical Chemistry C",
        "year": 2012
    },
    "EDvU78ey": {
        "id": "EDvU78ey",
        "title": "A novel benzo[1,2- b:4,5- b\u2032]dithiophene-based conjugated polymer with a pendant diketopyrrolopyrrole unit for high-performance solar cells",
        "abstract": "A novel conjugated polymer of PBDT-TDPP-S was synthesized, which contains a donor unit of benzo[1,2-b:4,5-b\u2032]dithiophene in main chain and an acceptor unit of diketopyrrolopyrrole in side chain. This kind of side-chain donor-acceptor (D-A) polymer exhibited better solution processability, lower HOMO level (-5.34 eV), and more balanced carrier mobility relative to its corresponding main-chain D-A conjugated polymers. Using PBDT-TDPP-S as electron donor and [6,6]-phenyl-C71-butyric acid methyl ester (PC 71BM) as electron acceptor, the resulting polymer solar cells exhibited outstanding photovoltaic properties with a power conversion efficiency of 4.89%, an open-circuit voltage of 0.84 V, a short-circuit current of 10.04 mA cm-2, and a fill factor of 56.0%. \u00a9 2012 American Chemical Society.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Hua Tan",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Xianping Deng",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "JunTing Yu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Baofeng Zhao",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            },
            {
                "name": "Yafei Wang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yu Liu,",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Hongbin Wu",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            },
            {
                "name": "Yong Cao",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            }
        ],
        "venue": "Macromolecules",
        "year": 2013
    },
    "DT2hhv8q": {
        "id": "DT2hhv8q",
        "title": "Synthesis and optoelectronic properties of a novel dinuclear cyclometalated platinum(II) complex containing triphenylamine-substituted indolo[3,2-b] carbazole derivative in the single-emissive-layer WPLEDs",
        "abstract": "A novel bi-picolinic acid derivative of H2dipic-BTICz containing binary triphenylamine-substituted indolo[3,2-b]carbazole (BTICz) unit and its dinuclear platinum(II) complex of (dfppy)2Pt2(dipic-BTICz) were synthesized as a single-component emitter used in the white polymer light-emitting diodes (WPLEDs), where dfppy is 2-(2,4-difluorophenyl)pyridine and dipic-BTICz is an anion of H2dipic-BTICz. The photophysical and electrochemical properties of (dfppy)2Pt2(dipic-BTICz) were investigated. Compared with the reported mononuclear platinum complex of (dfppy)Pt(pic), (dfppy)2Pt2(dipic-BTICz) exhibited a red-shifted photoluminescent peak at 434 nm in dilute dichloromethane (10 -5 M), but a weakened and red-shifted aggregation emission peak at 640 nm besides its intrinsic emission at 445 nm in its neat films. Stable pure white emissions with CIE coordinates of (0.325\ufffd\ufffd0.005, 0.345\ufffd\ufffd0.015) and a maximum brightness of 208 cd/m2 were observed in the (dfppy)2Pt2(dipic-BTICz)-doped single-emissive-layer (SEL) PLEDs using a blend of poly(vinylcarbazole) and 2-(4-biphenyl)-5-(4-tert- butylphenyl)-1,3,4-oxadiazole as a host matrix at 1 wt % dopant concentrations under applied voltages from 9 to 14 V. It indicates that the intrinsic and aggregation emissions of this dinuclear platinum complex were effectively tuned by inserting a new BTICz fluorophore in the dual picolinic acid derivative. Therefore, it is a promising single-component emitter to get white emission in SEL PLEDs. ? 2014 Elsevier Ltd. All rights reserved.",
        "keywords": [
            "aggregation emission",
            "dinuclear platinum complex",
            "electrophosphorescence",
            "indolo[3",
            "2-b]carbazole",
            "white polymer light-emitting devices"
        ],
        "authors": [
            {
                "name": "Junting Yu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Jian Luo",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Qing Chen",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Keqi He",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Fanyuan Meng",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Xianping Deng",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yafei Wang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Hua Tan",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Haigang Jiang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "Tetrahedron",
        "year": 2014
    },
    "MmpWHJSy": {
        "id": "MmpWHJSy",
        "title": "Enhanced green electrophosphorescence from qxadiazole-functionalized iridium complex-doped devices using poly(9,9-dioctylfluorene) instead of poly(N-vinylcarbazole) as a host matrix",
        "abstract": "Optoelectronic properties of the oxadiazole-functionalized iridium complex-doped polymer light-emitting devices (PLEDs) are demonstrated with two different polymeric host matrices at the dopant concentrations 1-8%. The devices using a blend of poly(9,9-dioctylfluorene)(PFO) and 2-(4-biphenyl)-5-(4-tert- butylphenyl)-1,3,4-oxadiazole (PBD) as a host matrix exhibited a maximum luminance efficiency of 11.3cd/A at 17.6mA/cm 2. In contrast, the devices using a blend of poly(N-vinylcarbazole) (PVK) and PBD as a host matrix reveal only a peak luminance efficiency of 6.5cd/A at 4.1mA/cm 2. The significantly enhanced electrophosphorescent emissions are observed in the devices with the PFO-PBD blend as a host matrix. This indicates that choice of polymers in the host matrices is crucial to achieve highly efficient phosphorescent dye-doped PLEDs. \u00a9 2007 Chinese Physical Socity and IOP Publishing Ltd.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Luo Cui-Ping",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Ji Zhou",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Lei Wang",
                "org": "South China University of Technology(South China University of Technology,South China Univ. of Technol.),Guangzhou,China"
            },
            {
                "name": "Deng Ji-Yong",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Qin Zhi-Jun",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Zhu Mei-Xiang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Zhu Wei-Guo",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2007
    },
    "DZFi8SFr": {
        "id": "DZFi8SFr",
        "title": "A new donor-acceptor-donor ternary copolymer pending additional diketopyrrolopyrrole unit in the side of a donor for efficient solar cells",
        "abstract": "A new donor-acceptor-donor ternary copolymer PTh-BDT-2DTDPP was synthesized and characterized, in which two diketopyrrolopyrrole units were simultaneously incorporated into the side and main chains. Its thermal, photophysical and electrochemical properties, as well as morphology in a blending film were investigated. The bulk heterojunction polymer solar cells were made with a configuration of ITO/PEDOT:PSS/PTh-BDT-2DTDPP:PC61BM/LiF/Al. A maximum power conversion efficiency of 4.36% with a high open-circuit voltage of 0.78 V, a short-circuit current of 10.47 mA cm-2 and a fill factor of 53.0% was achieved in the cells under the illumination of AM 1.5, 100 mW cm-2. \u00a9 2013 Elsevier B.V. All rights reserved.",
        "keywords": [
            "bulk heterojunction",
            "diketopyrrolopyrrole",
            "donor-acceptor",
            "polymer solar cells"
        ],
        "authors": [
            {
                "name": "Hua Tan",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "JunTing Yu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yafei Wang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Jianhua Chen",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Qiang Tao",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yu Liu,",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Juan Huang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "Organic Electronics: physics, materials, applications",
        "year": 2013
    },
    "QkI8nzty": {
        "id": "QkI8nzty",
        "title": "Study on nucleic acid (CT-DNA and yeast tRNA) binding behaviors and cytotoxic properties of a heterodinuclear Ru(II)-Co(III) polypyridyl complex.",
        "abstract": "A heterodinuclear (Ru(II), Co(III)) metal polypyridyl complex [(phen)(2)Ru(bpibH(2))Co(phen)(2)](5+) {phen = 1,10-phenanthroline, bpibH(2) = 1,4-bis([1,10]phebanthroline-[5,6-d]imidazol-2-yl)-benzene} has been designed and synthesized. The comparative study on the interactions of the Ru(II)-Co(III) complex with calf thymus DNA (CT-DNA) and yeast tRNA has been investigated by UV-visible spectroscopy, fluorescence spectroscopy, viscosity, as well as equilibrium dialysis and circular dichroism (CD). The antitumor activities of the complex have been evaluated by MTT {3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide} method and Giemsa staining experiment. These results indicate that the structures of nucleic acids have significant effects on the binding behaviors of metal complexes. Furthermore, the complex demonstrates different antitumor activity against selected tumor cell lines in vitro, and can make the cell apoptosis.",
        "keywords": [
            "binding behavior",
            "cytotoxicity",
            "molecular recognition",
            "nucleic acid-binding",
            "nucleic acid",
            "fluorescence spectroscopy",
            "circular dichroism",
            "comparative study"
        ],
        "authors": [
            {
                "name": "Xiling Liang",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Xiaoqing Zou",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Lifeng Tan",
                "org": ""
            },
            {
                "name": "Weiguo Zhu",
                "org": "Key Lab of Environment-friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            }
        ],
        "venue": "Journal of inorganic biochemistry",
        "year": 2010
    },
    "Qtwu5s7R": {
        "id": "Qtwu5s7R",
        "title": "Highly efficient sharp red electroluminescence from europium complex-doped poly(9,9-dioctylfluorene) devices",
        "abstract": "The present work exhibits that a now europium complex containing bromine groups and its doped devices with poly(9,9-dioctylfluorene) blend. The devices emitted bright sharp red emissions at 612 nm with a maximum external quantum efficiency of 1.4% at 1.5 mA/cm 2 and a peak luminance of 278 cd/m 2 at 50.0 mA/cm 2 . Abstract Using a europium complex containing bromine groups as a guest dopant and a blend of poly(9,9-dioctylfluorene) and 2- tert -butylphenyl-5-biphenyl-1,3,4-oxadiazole as a host matrix, the polymer light-emitting devices exhibited bright red electroluminescent emissions at 612 nm with a full width at half maximum of 19 nm. The different spectral characteristics of photoluminescence and electroluminescence were analyzed. Highly efficient emission was observed in the devices with a maximum external quantum efficiency of 1.4% at 1.5 mA/cm 2 and a peak luminance of 278 cd/m 2 at 50.0 mA/cm 2 . 1 Introduction Europium complexes have attracted a great deal of attention because of their highly monochromatic red emission and 100% theoretical emission quantum efficiency in organic and polymeric light-emitting devices (OLEDs and PLEDs) in recent decades [1\u201314] . A great deal of progress was made in the europium complexes-doped OLEDs [3\u201310] . Kido et al. demonstrated how tri(dibenzoylmethane) (4,7-biphenyl-1,10-phenanthroline) europium (III) [Eu(DBM) 3 (Bphen)]-doped OLEDs afforded a high external quantum efficiency of 7.5 \u00b1 0.5% at 0.02 mA/cm 2 using triphenyldiamine (TPD) as a host matrix [3] . Ma et al. reported why tri(dibenzoyl-methane) (3,4,7,8-tetramethyl-1,10-phenanthroline) europium (III) [Eu(Tmphen) (DBM) 3 ]-doped OLEDs exhibited a maximum brightness of 2450 cd/m 2 at 20 V and a luminance efficiency of 9.0 cd/A at 0.012 mA/cm 2 using 4-(dicyanomethylene)-2- tert -butyl-6(1,1,7,7-tetramethyljulolidyl-9-enyl)-4H-pyran (DCJTB) as a host matrix [4] . However, europium complexes have not yet provided satisfactory performances in their doped PLEDs [11\u201314] . Jiang et al. exhibited tri3-[3\u2032,5\u2032-bis (phenylmethoxyl) phenyl]-1-(9-phenanthryl-1)propane-1,3-dione europium (III) [Eu(PPD) 3 ]-doped PLEDs with a maximum external quantum efficiency of 0.8% at 0.52 mA/cm 2 and a peak brightness of 62 cd/m 2 at 65 mA/cm 2 [11] . O\u2019Riordan et al. [12] demonstrated tri(dibenzoylmethane) (1,10-phenanthroline) europium (III) [Eu(DBM) 3 Phen]-doped poly( N -vinylcarbazole) (PVK) devices with a maximum brightness of 130 cd/m 2 at 400 mA/cm 2 and a maximum efficiency of 3.1 \u00d7 10 \u22122 % [12] . McGehee et al. reported tris(dinaphthoylmethane) (1,10-phenanthroline) Eu(DNM) 3 Phen-doped poly [2-(6\u2032-cyano-6\u2032-methylheptyloxy)-1,4-phenylene] (CNPPP) devices with a highest efficiency of 1.1% [13] . The europium complexes-doped PLEDs using polymers as host matrices have displayed lower luminous efficiency and luminance than the europium complexes-doped OLEDs employing organic small molecular dyes as host matrices. In order to improve the luminescent properties of europium complexes-doped devices, much effort was focused on the molecular design of new europium complexes with carrier-transporting ability. Various functionalized phenanthroline and benzimidazole derivatives were introduced into europium complexes to tune the carrier-transporting nature of europium complexes [3\u20139] , but no research work was reported on improving the efficiency of europium complexes by introducing heavy atoms into the second ancillary ligands of europium complexes. In this letter, we reported here our effort on achieving highly efficient europium complex-doped PLEDs. A europium complex, tri(dibenzoylmethane) (3,8-dibromo-1,10-phenanthroline) europium (III) [Eu(DBM) 3 (DBrPhen)], was employed for the first time as a guest in the devices with a blend of poly(9,9- dioctylfluorene) (PFO) and 2- tert -butylphenyl-5-biphenyl-1,3,4-oxadiazole (PBD) as a host matrix. In this complex, dibenzoylmethane (DBM) was chosen as the first ligand because its europium complexes had shown relatively high PL and EL efficiencies. 3,8-Dibromo-1,10-phenanthroline (DBrPhen) was designed as the second ligand based on the following considerations: firstly, 1,10-phenanthroline is a well known second ligand and can enhance the stability and volatility of its europium complexes; secondly, incorporating the bromine atoms into 1,10-phenanthroline may increase the rate constant of intersystem crossing (ISC) from singlet to triplet state, thereby improve the luminous efficiency of the europium complex owing to the heavy atom effect of bromine atoms, as described by Berberan-Santos [15] ; finally, substitution of the bromine atoms for the hydrogen atoms in phenanthroline can provide bulky space effect resulting in the suppression of molecular aggregation and concentration quenching. Hence, Eu(DBM) 3 (DBrPhen) should have improved opto-electronic properties. As expected, a maximum external quantum efficiency of 1.4% at 1.5 mA/cm 2 and a peak luminance of 278 cd/m 2 at 50.0 mA/cm 2 were achieved in the devices using Eu(DBM) 3 (DBrPhen) as dopant and PFO\u2013PBD blend as a host matrix. To the best of our knowledge, this is the first report of such a high efficiency in europium complex-doped PLEDs. 2 Experimental Eu(DBM) 3 (DBrPhen) was synthesized according to our previous work [16] . Its molecular structure and doped device configuration are shown in Fig. 1 . The devices were fabricated on a cleaned ITO glass substrate with a sheet resistance of 15 \u03a9/sq. A hole-injection layer of poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS), a hole-transporting layer of PVK and an emitting layer of Eu complex doped into the PFO\u2013PBD blend were spin-casted on the top of the ITO substrate successively. Their thickness was 50 nm, 40 nm and 80 nm, respectively, which was measured with an Alpha-step 500 surface profiler (Tencor). Barium (4 nm) used as the cathode was deposited on the top of emitting layer in vacuum (3 \u00d7 10 \u22124 Pa). The cathode was then capped with aluminum (150 nm) by vacuum deposition. The doping concentrations of Eu(DBM) 3 (DBrPhen) were 1%, 4% and 8%, respectively; and mass ratio of PBD was 30% in the PFO\u2013PBD blend. Typical active area of the devices was 0.15 mm 2 . The photoluminescence (PL) and electroluminescence (EL) properties were measured based on the literature [17] . 3 Results and discussion Fig. 2 shows the PL spectra of the PFO\u2013PBD blend film and Eu(DBM) 3 (DBrPhen)-doped PFO\u2013PBD films at different doping concentrations under excitation of 325 nm He\u2013Cd laser. Two emission peaks around 416 nm and 515 nm were exhibited in PL profiles of the doped PFO\u2013PBD films, which were similar to these in PL profile of the PFO\u2013PBD blend film. A rather weak Eu 3+ ion emission at 620 nm was only observed in the doped films at doping concentrations from 4% to 8%. This indicates that the energy transfer from the blend to the central Eu 3+ ion was inefficient under optical excitation. The PL emissions of the Eu(DBM) 3 (DBrPhen)-doped films are dominated by the emission of the PFO\u2013PBD blend. However, the EL spectra of Eu(DBM) 3 (DBrPhen)-doped PFO\u2013PBD devices showed intense characteristic Eu 3+ ion emission at different doping concentrations under electrical excitation, which are recorded in Fig. 3 and considerably different from the PL spectra in Fig. 2 . Three peaks at 574 nm, 612 nm and 648 nm were exhibited, which are assigned to 5 D 0 \u2192 7 F 0 , 5 D 0 \u2192 7 F 2 , 5 D 0 \u2192 7 F 3 transitions of Eu 3+ ion, respectively [12] . The dominating near-monochromatic emission peaked at 612 nm has a full width at half maximum of 19 nm. No emission from the PFO\u2013PBD blend was observed in the EL profiles. This implies that the emission from the PFO\u2013PBD blend was completely quenched by Eu(DBM) 3 (DBrPhen) in the EL emission of the devices. The substantial difference between the PL and EL spectra was also observed by others in europium complexes-doped devices [4,13,18] . It was attributed to different luminous mechanisms. For the PL emission, the energy cannot directly transfer to Eu(DBM) 3 (DBrPhen) until the photo-energy is absorbed by the PFO\u2013PBD blend. A very limited amount of emission from the europium complex is observed implies that the absorbed energy of the PFO\u2013PBD blend cannot transfer to Eu(DBM) 3 (DBrPhen) efficiently. In contrast, two processes lead to the EL emission: firstly, the injected electrons and holes recombine in the PFO\u2013PBD blend, and the blend then transfers energy to Eu(DBM) 3 (DBrPhen) by F\u00f6rster energy transfer; secondly, opposite carriers are directly trapped by Eu(DBM) 3 (DBrPhen) and recombine on the europium complex. The sharp Eu 3+ ion emission of the europium complex only observed in the EL spectra implies that the carrier-trapping rather than energy transfer mechanism dominates the EL emission of the devices. The current density\u2013voltage\u2013brightness characteristics of Eu(DBM) 3 (DBrPhen)-doped PFO\u2013PBD devices at different doping levels are shown in Fig. 4 , respectively. A maximum brightness of 278 cd/m 2 at 50.0 mA/cm 2 was achieved in the device with 4% doping concentration. It is known that the brightness of europium complexes-doped PLEDs is on average \u223c250 cd/m 2 [12] , Hence, brightness of 278 cd/m 2 is comparable to those in europium complexes-doped PLEDs reported by others [11\u201313] . On the other hand, we note that the turn-on voltage of the devices increases from 9.2 V to 14.4 V with increasing doping level from 1% to 8%. This indicates that the device is mainly operated by the carrier-trapping mechanism based on the identical phenomenon observed by Chang et al. in platinum complexes-doped devices [19] . The carrier-trapping effect of the europium complex in the devices was further supported by the electrochemical properties of Eu(DBM) 3 (DBrPhen). The highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) energy levels of the complex were determined to be \u22125.6 eV and \u22122.4 eV by cyclic voltammetry, respectively. These levels indicate that Eu(DBM) 3 (DBrPhen) can function adequately as a carrier trap in the devices because the LUMO and HOMO levels of PFO are \u22122.1 eV and \u22125.8 eV, respectively [20] . Subsequently, the trapped carriers can easily recombine on the europium complex providing efficient EL in the devices. The external quantum efficiency\u2013current density characteristics of Eu(DBM) 3 (DBrPhen)-doped PFO\u2013PBD devices are shown in Fig. 5 at different doping levels. The highest external quantum efficiency of 1.4% was achieved at a current density of 1.5 mA/cm 2 in the device with 4% doping concentration. In previous europium complex-doped PLEDs, the efficiency was generally less than 1% and obtained at a lower current density less than 0.5 mA/cm 2 [11\u201314] . Hence, the device exhibited here an elevated efficiency. More importantly, the decrease of the efficiency was efficiently suppressed with increasing current density in the device. At a current density of 50 mA/cm 2 , the device still displayed a high external quantum efficiency of 0.55% and a maximum brightness of 278 cd/m 2 . This implies that emission quenching of the europium complex is reduced at a high current density. Table 1 summarizes device performances of the Eu(DBM) 3 (DBrPhen)-doped PFO\u2013PBD devices. Improved efficiency and brightness were observed in the devices at 1% and 8% doping concentrations. We believe that the improvement of device performances is mainly attributed to the modified europium complex by incorporating bromine-groups into phenanthroline. As the halogen-based iridium complexes were recently observed to have improved luminous efficiency in the OLEDs owing to the heavy atom effect of halogen groups [21] , we suggest that the effect should facilitate highly efficient emission of the europium complex. In order to support this suggestion, further experiments are ongoing currently. 4 Conclusion The PL and EL properties of Eu(DBM) 3 (DBrPhen) with 3,8-dibromo-1,10-phenanthroline ligand were studied in the doped PFO\u2013PBD devices. Bright red EL emissions at 612 nm with a full width at half maximum of 19 nm were exhibited. The maximum external quantum efficiency of 1.4% at 1.5 mA/cm 2 and a peak luminance of 278 cd/m 2 at 50.0 mA/cm 2 were achieved in the devices. Although the devices were not optimized, the efficiency of the devices is so far the highest compared with those of other europium complexes-doped PLEDs. The result shows that Eu(DBM) 3 (DBrPhen) can afford significantly improved optoelectronic property in the devices. Acknowledgements The authors thank the National Natural Science Foundation of China (50473046), the Science Foundation of the Ministry of Education of China (Project No. 204097) and the Outstanding Youth Foundation of Hunan Province (Project No. 04JJ1002) for the financial support. One of the authors (Weiguo Zhu) is grateful to Dr. Ahmed Iraqi (Department of Chemistry, University of Sheffield) for valuable discussion. Appendix A Supplementary data Supplementary data associated with this article can be found, in the online version, at doi:10.1016/j.cplett.2006.11.070 . Appendix A Supplementary data Supplementary data 1 Supplementary data 2 References [1] J. Pei X. Liu W. Yu Y. Lai Y. Liu Y. Cao Macromolecules 35 2002 7224 [2] Q.D. Liang Q.J. Cai E.T. Kang K.G. Neoh F.R. Zhu W. Huang J. Mater. Chem. 4 2004 2741 [3] T.W. Canzler J. Kido Org. Electronic. 7 2006 29 [4] J. Fang H. You J. Gao D. Ma Chem., Phys. Lett. 392 2004 11 [5] T. Oyamada Y. Kawamura T. Koyama H. Sasabe C. Adachi Adv. Mater. 16 2004 1082 [6] P. Sun J. Duan H. Shih C. Chang Appl. Phys. Lett. 81 2002 792 [7] M. Sun H. Xin K.Z. Wang Y.A. Zhang L.P. Jin C. Huang Chem. Commun. 2003 702 [8] H. Xin M. Sun K.Z. Wang Y.A. Zhang L.P. Jin C.H. Huang Chem. Phys. Lett. 388 2004 55 [9] Z. Hong Adv. Mater. 13 2001 1241 [10] N.A.H. Male O.V. Salata V. Christou Synth. Metal. 126 2002 7 [11] X. Jiang A.K.Y. Jen G.D. Phelan D. Huang T.M. Londergan L.R. Dalton R.A. Register Thin Solid Films 416 2002 212 [12] A. O\u2019Riordan Thin Solid Films 491 2005 264 [13] M.D. McGehee Adv. Mater. 11 1999 1349 [14] J.B. Peng N. Takada N. Minami Thin Solid Films 405 2002 224 [15] M.N. Berberan-Santos Phys. Chem. Comm. 3 2000 1 [16] W.G. Zhu T.S. Yuan X.Q. Wei Z.Y. Lu Y. Huang Y. Liu M.G. Xie Chem. J. Chin. Univ. 21 2000 1527 [17] J. Liu Chin. Phys. Lett. 22 2005 723 [18] M.R. Robinson J.C. Ostrowski G.C. Bazan M.D. McGehee Adv. Mater. 15 2003 1547 [19] S. Chang Inorg. Chem. 45 2006 137 [20] X. Gong D. Moses A.J. Heeger S. Liu A.K.Y. Jen Appl. Phys. Lett. 83 2003 183 [21] C.L Yang, L.Q. Chen, J.G. Qin, Faming Zhuanli Shenqing Gongkai Shuomingshu CN 1803783 A.",
        "keywords": [
            "full width at half maximum",
            "external quantum efficiency",
            "electroluminescence"
        ],
        "authors": [
            {
                "name": "Yu Liu",
                "org": "Department of Chemistry, Qiongzhou University, Wuzhishan 572200, China"
            },
            {
                "name": "Jingdian Li",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Chun Li",
                "org": "Institute of Polymer Optoelectronics Materials and Devices, South China University of Technology, Guangzhou 510640, China"
            },
            {
                "name": "Jungeng Song",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Youlong Zhang",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Junbiao Peng",
                "org": "Institute of Polymer Optoelectronics Materials and Devices, South China University of Technology, Guangzhou 510640, China"
            },
            {
                "name": "Xiayu Wang",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Yong Cao",
                "org": "Institute of Polymer Optoelectronics Materials and Devices, South China University of Technology, Guangzhou 510640, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            }
        ],
        "venue": "Chemical Physics Letters",
        "year": 2007
    },
    "bvjWSFL8": {
        "id": "bvjWSFL8",
        "title": "White organic light emitting devices with hybrid emissive layers combining phosphorescence and fluorescence",
        "abstract": "",
        "keywords": [
            "organic light emitting diode",
            "current density"
        ],
        "authors": [
            {
                "name": "Gangtie Lei",
                "org": ""
            },
            {
                "name": "Xiaolan Chen",
                "org": ""
            },
            {
                "name": "Lei Wang",
                "org": ""
            },
            {
                "name": "Meixiang Zhu",
                "org": ""
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            },
            {
                "name": "Liduo Wang",
                "org": ""
            },
            {
                "name": "Yong Qiu",
                "org": ""
            }
        ],
        "venue": "Journal of Physics D-applied Physics",
        "year": 2008
    },
    "Ra0WjfQa": {
        "id": "Ra0WjfQa",
        "title": "Improving optoelectronic properties of the 2,7-polyfluorene derivatives with carbazole and oxadiazole pendants by incorporating the blue-emitting iridium complex pendants in C-9 position of fluorine unit",
        "abstract": "To study the influence of a blue-emitting iridium complex pendant on the optoelectronic properties of its 2,7-polyfluorene (PF) derivatives with the carbazole and oxadiazole pendants, a class of 2,7-PF derivatives containing carbazole, oxadiazole, and/without the cyclometalated iridium complex pendants in the C-9 positions of fluorene unit were synthesized. Their thermal, photophysical, electrochemical, and electroluminescent (EL) properties were investigated. Among these 2,7-PF derivatives (P1-P4), P2 and P3 exhibited higher photoluminescence efficiency in dichloromethane and better EL properties in the single-emissive-layer polymer light-emitting devices. The highest brightness of 3888 cd/m2 and the maximum current efficiency of 2.9 cd/A were obtained in the P2- and P3-based devices, respectively. The maximum brightness and efficiency levels were 1.7 and 2.1 times, respectively, higher than the corresponding levels from the parent 2,7-PF derivative (P1)-based devices. Our work indicated that EL properties of 2,7-PF derivatives can be improved by introducing the blue-emitting iridium complex into the alkyl side chain of fluorine unit as pendant. \u00a9 2011 Wiley Periodicals, Inc.",
        "keywords": [
            "2",
            "7-polyfluorene",
            "conjugated polymers",
            "iridium complex",
            "light-emitting diodes (led)",
            "metal-polymer complexes"
        ],
        "authors": [
            {
                "name": "Hua Tan",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "JunTing Yu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yafei Wang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Jianmin Li",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Jiaojiao Cui",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Jian Luo",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Danyan Shi",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Kai Chen",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yu Liu,",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Kaixuan Nie",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "Journal of Polymer Science, Part A: Polymer Chemistry",
        "year": 2012
    },
    "gpHfqmOT": {
        "id": "gpHfqmOT",
        "title": "Dinuclear cyclometalated platinum (II) complexes: Synthesis, photophysics, and monomolecular electroluminescence",
        "abstract": "Two novel dinuclear platinum (II) complexes of (C 12Rppy) 2Pt 2(dipic) (R = H and F) were synthesized and characterized, where C 12Rppy is a 2-phenylpyridine derivative modified with dodecyloxy groups and dipic is a bi-picolinic acid derivative linked by biphenyl unit. Their physical, surface morphologies and optoelectronic properties, as well as molecular orbitals calculation were investigated. Intense excimer emission for both dinuclear platinum (II) complexes were observed in their neat films rather than in their dichloromethane solution under photo-excitation. In contrary, these dinuclear platinum (II) complexes exhibited a stronger monomolecular emission instead of excimer emission in their doped single-emissive-layer polymer light-emitting devices (PLEDs) under electric field owing to the effect of two alkyloxy groups in the ligand of 2-phenylpyridine. Better electroluminescent emission with a maximum current efficiency of 1.3 cd/A and a maximum luminance of 1407 cd/cm 2 was observed in the (C 12Hppy) 2Pt 2(dipic)-doped devices. To our best knowledge, the performance of (C 12Rppy) 2Pt 2(dipic) (R = H and F) is among the top values for the solution-processed dinuclear platinum (II) complex-based PLEDs reported so far. \u00a9 2012 Elsevier B.V. All rights reserved.",
        "keywords": [
            "dinuclear platinum (ii) complex",
            "electroluminescence",
            "excimer",
            "polymer light emitting devices"
        ],
        "authors": [
            {
                "name": "Yafei Wang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Jian Luo",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yu Liu,",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Zhiyong Zhang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Hua Tan",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "JunTing Yu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Gangtie Lei",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "Organic Electronics: physics, materials, applications",
        "year": 2012
    },
    "uqatzWjc": {
        "id": "uqatzWjc",
        "title": "Synthesis, optoelectronic properties of a dinuclear platinum(II) complex containing a binary cyclometalated ligand in the single-emissive-layer PLEDs.",
        "abstract": "A novel dinuclear platinum complex of (dfppy-mhb-dfppy)Pt(2)(acac)(2) was synthesized and characterized, where dfppy-mhb-dfppy is a binary C^N cyclometalated ligand containing two bridged 2,4-difluorophenylpyridine (dfppy) units and acac is 2,4-pentanedione anion. Compared to previously reported dinuclear platinum complexes with a binary ancillary ligand, this dinuclear platinum complex showed more intense excimer emission, peaking at 617 nm, besides its intrinsic emission in dilute dichloromethane solution. Single-emissive-layer (SEL) polymer light-emitting devices (PLEDs) using (dfppy-mhb-dfppy)Pt(2)(acac)(2) as dopant and a blend of poly (N-vinylcarbazole) (PVK) and 2-(4-biphenyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole (PBD) as host matrix exhibited stable white emission at 1 wt% doping concentration under applied voltages from 7 V to 11 V. The stable white emission observed in the (dfppy-mhb-dfppy)Pt(2)(acac)(2)-doped SEL PLEDs indeed implies that the dinuclear platinum complex constructed by a binary cyclometalated ligand has a potential application in white-emitting SEL PLEDs.",
        "keywords": [],
        "authors": [
            {
                "name": "Jian Luo",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yu Liu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Qing Chen",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Danyan Shi",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Ying Huang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Junting Yu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Yafei Wang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Zhiyong Zhang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Gangtie Lei",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "Dalton transactions (Cambridge, England : 2003)",
        "year": 2013
    },
    "ArKXpEr8": {
        "id": "ArKXpEr8",
        "title": "Red electroluminescence from a novel europium \u03b2-diketone complex with acylpyrazolone ligand",
        "abstract": "A novel poly-ligand europium \u03b2-diketone complex was prepared, which contains ligand of 1-phenyl-3-methyl-4(4-butylbenzoyl)-5-pyrazolone (HPMBBP). Its structure is Eu(TTA) 2 (PMBBP)Phen. We investigated its PL and EL properties. When it was used as emitting material, the new Eu-complex exhibited intense photoluminescence (PL) and electroluminescence (EL) at 613 nm in a fabricated three-layer electroluminescent device: ITO/TPD/Eu(TTA) 2 (PMBBP)Phen/Alq 3 /Mg:Ag. The maximum luminance of 16 cd/m 2 from the device was obtained at 12.5 V.",
        "keywords": [
            "electroluminescent device",
            "europium \u03b2-diketone",
            "acylpyrazolone",
            "synthesis",
            "electroluminescence"
        ],
        "authors": [
            {
                "name": "Weiguo Zhu",
                "org": "Department of Chemistry, Xiangtan University, Xiangtan 411105, People's Republic of China"
            },
            {
                "name": "Qing Jiang",
                "org": "Department of Chemistry, Sichuan University, Chengdu 610064, People's Republic of China"
            },
            {
                "name": "Zhiyun Lu",
                "org": "Department of Chemistry, Sichuan University, Chengdu 610064, People's Republic of China"
            },
            {
                "name": "Xiaoqiang Wei",
                "org": "Department of Chemistry, Sichuan University, Chengdu 610064, People's Republic of China"
            },
            {
                "name": "Minggui Xie",
                "org": ""
            },
            {
                "name": "Dechun Zou",
                "org": "Department of Applied Science for Electronics and Materials, Interdisiplinary Graduate School of Engineering Sciences, Kyushu University, Kasuga 6-1, Fukuoka 816-8580, Japan"
            },
            {
                "name": "Tetsuo Tsutsui",
                "org": "Department of Applied Science for Electronics and Materials, Interdisiplinary Graduate School of Engineering Sciences, Kyushu University, Kasuga 6-1, Fukuoka 816-8580, Japan"
            }
        ],
        "venue": "Synthetic Metals",
        "year": 2000
    },
    "h77Dtt6Q": {
        "id": "h77Dtt6Q",
        "title": "Novel pyrazoline derivative used as light emitter in blue organic electroluminescent devices",
        "abstract": "A novel pyrazoline derivative, 3-(4-methoxyphenyl )-5-[4-(1,1-dimethylethylphenyl)]-4,5-dihydro-1-phenyl 1- H -Pyrazole ( P 3 ) was designed and synthesized. Its structure was elucidated by IR, 1 H NMR, MS, UV and elementary analysis. It had hole-transporting ability, good film-formation, and excellent PL property. The device with a structure of ITO/PVK/ P 3 /Al could emit blue light (451 nm) and the turn-on voltage was 25 V. Its EL spectrum was almost identical with the PL spectrum of P 3 . The maximum luminance of 200 cd m \u22122 was achieved at 29 V. Another device of ITO/PVK+ P 3 /Al could emit blue light with emission peak of 431 nm. The emission was resulting from P 3 too. Both of the two devices showed good (electroluminescence) EL properties, and P 3 was considered as a kind of blue OELM with high performance.",
        "keywords": [
            "organic electroluminescent devices",
            "blue emitter",
            "pyrazoline derivative",
            "electroluminescence",
            "spectrum"
        ],
        "authors": [
            {
                "name": "Zhiyun Lu",
                "org": "Department of Chemistry, Sichuan University, Chengdu 610064, People's Republic of China"
            },
            {
                "name": "Qing Jiang",
                "org": "Department of Chemistry, Sichuan University, Chengdu 610064, People's Republic of China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Chemistry, Xiangtan University, Xiangtan 411105, People's Republic of China"
            },
            {
                "name": "Minggui Xie",
                "org": ""
            },
            {
                "name": "Yanbing Hou",
                "org": "Institute of Optoelectronic Technology, Northern Jiaotong University, Beijing 100044, People's Republic of China"
            },
            {
                "name": "Xiaohong Chen",
                "org": "Institute of Optoelectronic Technology, Northern Jiaotong University, Beijing 100044, People's Republic of China"
            },
            {
                "name": "Zhenjia Wang",
                "org": "Institute of Optoelectronic Technology, Northern Jiaotong University, Beijing 100044, People's Republic of China"
            }
        ],
        "venue": "Synthetic Metals",
        "year": 2000
    },
    "EP2TWjln": {
        "id": "EP2TWjln",
        "title": "Efficient blue emission from pyrazoline organic light emitting diodes",
        "abstract": "Two kinds of pyrazoline derivatives, 3-(4-chlorophenyl)-4,5-dihydro-1,5-diphenyl 1- H -Pyrazole, ( P 1 ) and 3-(4-methoxyphenyl)-4,5-dihydro-1,5-diphenyl 1- H -Pyrazole ( P 2 ) were synthesized. They showed efficient photoluminescence (PL) in both solid state and solution. The emission peak of P 1 was observed at 450 nm and that of P 2 was at 432 nm. Two types of organic electroluminescent devices (OELDs) using these materials as emitting layer were fabricated, one is a three-layered structure device fabricated by dry process and another is a single or double layer structure device fabricated by a wet technique. These materials were found to function as good blue light-emitting materials for OELDs. The device with a structure of ITO/TPD/ P 1 /Alq 3 /Mg:Ag showed a turn-on voltage of 3.5 V, while the device using P 2 instead of P 1 gave a turn-on voltage of 3 V, both of them give green light resulting from Alq 3 and the maximum light intensity was 5710 cd/m 2 under driving voltage of 8.5 V. The device of ITO/PVK+ P 1 /Alq 3 /Al emitted bright blue light resulting from P 1 . It exhibited a maximum luminance of 200 cd/m 2 at a driving voltage of 12 V, and the device of ITO/PVK+ P 2 /Al exhibited blue light of 200 cd/m 2 at a driving voltage of 11 V.",
        "keywords": [
            "pyrazoline derivatives",
            "electroluminescence",
            "blue light emission",
            "organic light emitting diode",
            "double layer"
        ],
        "authors": [
            {
                "name": "Zhiyun Lu",
                "org": "Department of Chemistry, Sichuan University, Chengdu 610064, People's Republic of China"
            },
            {
                "name": "Qing Jiang",
                "org": "Department of Chemistry, Sichuan University, Chengdu 610064, People's Republic of China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Chemistry, Xiangtan University, Xiangtan 411105, People's Republic of China"
            },
            {
                "name": "Minggui Xie",
                "org": ""
            },
            {
                "name": "Yanbing Hou",
                "org": "Institute of Optoelectronics, Northern Jiaotong University, Beijing 100044, People's Republic of China"
            },
            {
                "name": "Xiaohong Chen",
                "org": "Institute of Optoelectronics, Northern Jiaotong University, Beijing 100044, People's Republic of China"
            },
            {
                "name": "Zhenjia Wang",
                "org": "Institute of Optoelectronics, Northern Jiaotong University, Beijing 100044, People's Republic of China"
            },
            {
                "name": "Dechun Zou",
                "org": "Department of Applied Science for Electronics and Materials, Interdisiplinary Graduate School of Engineering Sciences, Kyushu University, Kasuga 6-1, Fukuoka 816-8580, Japan"
            },
            {
                "name": "Tetsuo Tsutsui",
                "org": "Department of Applied Science for Electronics and Materials, Interdisiplinary Graduate School of Engineering Sciences, Kyushu University, Kasuga 6-1, Fukuoka 816-8580, Japan"
            }
        ],
        "venue": "Synthetic Metals",
        "year": 2000
    },
    "F9WbqB8a": {
        "id": "F9WbqB8a",
        "title": "Synthesis of Pyrazolines Used as Blue Organic Electroluminescence Materials",
        "abstract": "Three kinds of pyrazolines were designed and synthesized. Their structures were elucidated by IR, 1HNMR, MS, UV and elemental analysis. Their luminescent properties were determined, which indicated that they had strong blue fluorescent properties. One of them was designed to have good film formation. All the three kinds of pyrazolines can be used as blue organic electroluminescence materials (OELMs).",
        "keywords": [
            "Blue organic electroluminescence materials",
            "Fluorescence",
            "Pyrazolines",
            "Synthesis"
        ],
        "authors": [
            {
                "name": "Zhiyun Lu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Qing Jiang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "MingGui Xie",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Chinese Chemical Letters",
        "year": 1999
    },
    "HbVBjSio": {
        "id": "HbVBjSio",
        "title": "Synthesis and Fluorescent Properties of New Binuclear Europium \u03b2-Diketone Chelates EumY1-m(TTA)3phen as Red Electroluminescent Materials",
        "abstract": "A new type of binuclear europium \u03b2-diketone chelates EumY1-m (TTA)3phen (0\u2264 m \u22641) and the influence of the proportion of Y1+ on fluorescence intensity of the Eu-complexes were studied. It was found the proportion of Y3+ could affect the fluorescence properties and the film formation seriously, only m\u22650.5.Y3+ could increase the luminescent intensity and improve the film formation. As a result, three new binuclear europium \u03b2-diketone chelates consisted of Eum Y1-m (TTA)3phen (m=0.9, 0.7 and 0.5) were designed and synthesized. Their structures were elucidated by IR, UV, DSC and Elementary Analysis. Their PL properties were studied. The results showed that the three binuclear europium \u03b2-diketone chelates had better PL properties and film formation than Eu(TTA)3phen. They could emit sharply red light, and fluorescent wavelength of them was all at 613nm (half bandwidth: 10nm). They can be used as red organic electroluminescent materials (OELMs) in organic electroluminescent devices (OELDS).",
        "keywords": [
            "Europium \u03b2-diketone chelate",
            "Fluorescence properties",
            "Photoluminescence",
            "Synthesis"
        ],
        "authors": [
            {
                "name": "Weiguo Zhu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "XiaoQiang Wei",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Zhiyun Lu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Qing Jiang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "MingGui Xie",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Chinese Chemical Letters",
        "year": 1999
    },
    "sys2V3lE": {
        "id": "sys2V3lE",
        "title": "Synthesis and Characteristics of Thienyltrifluroacetone-acylpyrazolone-phenanthroline-europium Chelate",
        "abstract": "A novel chelate Eu(TTA) 2(PMTBBP)Phen, which contained ligand 1-pheny-3-methyl-4-(4\u2032-t-butylbenzoyl)-5-pyrazolone (HPMTBBP), 4,4,4-trifluro-1-(2-thienyl)-1, 3-butandione (HTTA) and phenanthroline(Phen), was synthesized. Its chemical structure was elucidated by IR, UV, 1H NMR, MS, DSC and elementary analysis. The influence of acylpyrazolone on fluorescent intensity of the new chelate was studied. The results showed that Eu (TTA) 2 (PMTBBP) Phen had more excellent PL properties and better film formation than that of Eu(TTA) 3Phen.",
        "keywords": [
            "Acylpyrazolone",
            "Europium complex",
            "Fluorescent property",
            "Synthesis"
        ],
        "authors": [
            {
                "name": "Weiguo Zhu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "TongSuo Yuan",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "XiaoQiang Wei",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Zhiyun Lu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yan Huang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yu Liu,",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "MingGui Xie",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities",
        "year": 2000
    },
    "gF5RzSrh": {
        "id": "gF5RzSrh",
        "title": "Red Mechanoluminescence and Photoluminescence from Novel Europium Complexes",
        "abstract": "Two new binuclear (europium and lanthanum) \u03b2-diketone complexes Eu0.9La0.1(TTA)3Phen and Eu0.5La0.5(TTA)3Phen in which Phen is 1,10-phenanthroline, TTA is an anion of thenoyltrifluoroacetone (HTTA) were synthesized for the first time. They showed intense photoluminescence (PL) and mechanoluminescence (ML), and had their maximum PL and ML spectra peaked at 613.5 nm with half bandwidth of 10 nm respectively. Their PL and ML intensity were obviously stronger than these from Eu(TTA)3Phen. It is considered that binuclear (europium and lanthanum) \u03b2-diketones complexes are promising ML and PL materials.",
        "keywords": [
            "Europium \u03b2-diketone chelate",
            "Mechanoluminescence (ML)",
            "Photoluminescence (PL)",
            "Synthesis"
        ],
        "authors": [
            {
                "name": "Weiguo Zhu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "TongSuo Yuan",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "XiaoQiang Wei",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Zhiyun Lu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yan Huang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yu Liu,",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Qiang Peng",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "MingGui Xie",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Chinese Chemical Letters",
        "year": 2000
    },
    "JRAHSDgv": {
        "id": "JRAHSDgv",
        "title": "Carrier-transporting and blue electroluminescence properties of a novel pyrazoline derivative",
        "abstract": "A novel compound of pyrazoline derivative, 3-(4-methoxyphenyl)-5-[4-(1,1-dimethylethylphenyl)]-4,5-dihydro-1-phenyl 1H-Pyrazole (PYZ) has been synthesized. It has a good photoluminescence property and could give blue fluorescence. Four devices have been fabricated to study the carrier-transporting and electroluminescence properties of PYZ. The results indicate that PYZ is a good blue electroluminescent material. The emission peak is observed at 449 nm and the half bandwidth is about 80 nm, showing that it could emit pure blue light. As to carrier-transporting property, PYZ is found to have electron-transporting ability besides its excellent hole-transporting ability.",
        "keywords": [],
        "authors": [
            {
                "name": "Zhiyun Lu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "TongSuo Yuan",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yu Liu,",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "XiaoQiang Wei",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "MingGui Xie",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yong Qiu",
                "org": "Tsinghua University(Tsinghua University,Tsinghua Univ,Tsinghua Univ.),Beijing,China"
            },
            {
                "name": "Gao Yu-Di",
                "org": ""
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2000
    },
    "HLBi1y6V": {
        "id": "HLBi1y6V",
        "title": "Synthesis of a novel blue- light- emitting polymer material bearing coumarin pendants",
        "abstract": "A novel blue luminescent polymer bearing coumarin pendants was prepared. Its luminescent properties were determined indicating that it had strong blue fluorescent properties and good film formation ability. This novel polymer can be used as a blue organic electroluminescent material (OELM) in organic electroluminescent devices.",
        "keywords": [
            "blue organic electroluminescent material",
            "coumarin",
            "fluorescence",
            "polymer",
            "synthesis"
        ],
        "authors": [
            {
                "name": "Zhiyun Lu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "TongSuo Yuan",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "YanLai Chen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "XiaoQiang Wei",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "MingGui Xie",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Chinese Chemical Letters",
        "year": 2002
    },
    "DGwjQlGM": {
        "id": "DGwjQlGM",
        "title": "Novel binuclear europium \u03b2-diketone chelate used as red emitter in organic electroluminescent device",
        "abstract": "A novel binuclear europium and yttrium \u03b2 -diketone complex EuY(TTA) 6 Phen 2 was synthesized. The electroluminescent device using it as an emitter was fabricated. When the structure of device is ITO/TPD/EuY(TTA) 6 Phen 2 /Alq 3 /Mg:Ag, the emission peak of 613 nm and the luminance of 99 cd/m 2 at 11 V from the device have been achieved. The results showed that the new \u03b2 -diketone chelate possessed better PL and EL properties, and film formation than those of Eu(TTA) 3 Phen.",
        "keywords": [
            "synthesis electroluminescent device",
            "\u03b2 -diketone binuclear europium complex",
            "electroluminescence"
        ],
        "authors": [
            {
                "name": "Weiguo Zhu",
                "org": ""
            },
            {
                "name": "Qing Jiang",
                "org": "Department of Chemistry, Sichuan University, Chengdu 610064, PR China"
            },
            {
                "name": "Zhiyun Lu",
                "org": "Department of Chemistry, Sichuan University, Chengdu 610064, PR China"
            },
            {
                "name": "Xiaoqiang Wei",
                "org": "Department of Chemistry, Sichuan University, Chengdu 610064, PR China"
            },
            {
                "name": "Minggui Xie",
                "org": "Department of Chemistry, Sichuan University, Chengdu 610064, PR China"
            },
            {
                "name": "Dechun Zou",
                "org": "Department of Applied Science for Electronics and Materials, Interdisiplinary Graduate School of Engineering Sciences, Kyushu University, Kasuga 6-1, Fukuoka 816-8580, Japan"
            },
            {
                "name": "Tetsuo Tsutsui",
                "org": "Department of Applied Science for Electronics and Materials, Interdisiplinary Graduate School of Engineering Sciences, Kyushu University, Kasuga 6-1, Fukuoka 816-8580, Japan"
            }
        ],
        "venue": "Thin Solid Films",
        "year": 2000
    },
    "n3sqHJEm": {
        "id": "n3sqHJEm",
        "title": "Improved Photovoltaic Performance of a Side\u2010Chain D\u2013A Polymer in Polymer Solar Cells by Shortening the Phenyl Spacer between the D and A Units",
        "abstract": "",
        "keywords": [
            "polymer solar cells"
        ],
        "authors": [
            {
                "name": "wenyan su",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "qunping fan",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "manjun xiao",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "jianhua chen",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "pei zhou",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "bin liu",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "hua tan",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "yu liu",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "renqiang yang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "weiguo zhu",
                "org": "uc berkeley college of chemistry"
            }
        ],
        "venue": "Macromolecular Chemistry and Physics",
        "year": 2014
    },
    "AG2j0jZz": {
        "id": "AG2j0jZz",
        "title": "Synthesis, characterization and photovoltaic properties of two-dimensional conjugated polybenzodithiophene derivatives appending diketopyrrolopyrrole units as side chain",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jianhua chen",
                "org": ""
            },
            {
                "name": "manjun xiao",
                "org": ""
            },
            {
                "name": "wenyan su",
                "org": ""
            },
            {
                "name": "xiongwei duan",
                "org": ""
            },
            {
                "name": "linrui duan",
                "org": ""
            },
            {
                "name": "wenhong peng",
                "org": ""
            },
            {
                "name": "hua tan",
                "org": ""
            },
            {
                "name": "renqiang yang",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Polymer",
        "year": 2014
    },
    "Cbymjmfy": {
        "id": "Cbymjmfy",
        "title": "Improve the photovoltaic performance of new quinoxaline-based conjugated polymers from the view of conjugated length and steric hindrance",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "dan ouyang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "manjun xiao",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "dangqiang zhu",
                "org": "chinese academy of sciences"
            },
            {
                "name": "weiguo zhu",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "zhengkun du",
                "org": "chinese academy of sciences"
            },
            {
                "name": "ning wang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "yuanhang zhou",
                "org": "chinese academy of sciences"
            },
            {
                "name": "xichang bao",
                "org": "chinese academy of sciences"
            },
            {
                "name": "renqiang yang",
                "org": "chinese academy of sciences"
            }
        ],
        "venue": "",
        "year": 2014
    },
    "LDa6Jqzd": {
        "id": "LDa6Jqzd",
        "title": "Significantly improved photovoltaic performance of the triangular-spiral TPA(DPP\u2013PN)3 by appending planar phenanthrene units into the molecular terminals",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "youming zhang",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "xichang bao",
                "org": "chinese academy of sciences"
            },
            {
                "name": "manjun xiao",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "hua tan",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "qiang tao",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "yafei wang",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "yu liu",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "renqiang yang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "weiguo zhu",
                "org": "uc berkeley college of chemistry"
            }
        ],
        "venue": "",
        "year": 2014
    },
    "hEDKRUY9": {
        "id": "hEDKRUY9",
        "title": "Improved photovoltaic performance of star-shaped molecules with a triphenylamine core by tuning the substituted position of the carbazolyl unit at the terminal",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "pei zhou",
                "org": "ministry of education"
            },
            {
                "name": "dongfeng dang",
                "org": "ministry of education"
            },
            {
                "name": "manjun xiao",
                "org": "ministry of education"
            },
            {
                "name": "qiong wang",
                "org": "ministry of education"
            },
            {
                "name": "juan zhong",
                "org": "ministry of education"
            },
            {
                "name": "hua tan",
                "org": "ministry of education"
            },
            {
                "name": "yong pei",
                "org": "ministry of education"
            },
            {
                "name": "renqiang yang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "weiguo zhu",
                "org": "ministry of education"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "lvVhEiYc": {
        "id": "lvVhEiYc",
        "title": "Improved photovoltaic performance of a 2D-conjugated benzodithiophene-based polymer by the side chain engineering of quinoxaline",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "qunping fan",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "manjun xiao",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "yu liu",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "wenyan su",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "huishan gao",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "hua tan",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "yafei wang",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "gangtie lei",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "renqiang yang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "weiguo zhu",
                "org": "uc berkeley college of chemistry"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "9zNGkrWP": {
        "id": "9zNGkrWP",
        "title": "Solution-processed, indacenodithiophene-based, small-molecule organic field-effect transistors and solar cells",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "deyu liu",
                "org": "ocean university of china"
            },
            {
                "name": "manjun xiao",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "zhengkun du",
                "org": "chinese academy of sciences"
            },
            {
                "name": "yan yan",
                "org": "city university of hong kong"
            },
            {
                "name": "liangliang han",
                "org": "chinese academy of sciences"
            },
            {
                "name": "v a l roy",
                "org": "city university of hong kong"
            },
            {
                "name": "mingliang sun",
                "org": "city university of hong kong"
            },
            {
                "name": "weiguo zhu",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "chun sing lee",
                "org": "city university of hong kong"
            },
            {
                "name": "renqiang yang",
                "org": "chinese academy of sciences"
            }
        ],
        "venue": "",
        "year": 2014
    },
    "uHPtwoTv": {
        "id": "uHPtwoTv",
        "title": "Enhancing the photovoltaic properties of terpolymers containing benzo[1,2-b:4,5-b\u2032]dithiophene, phenanthro[4,5-abc]phenazine and benzo[c][1,2,5]thiadiazole by changing the substituents",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "qunping fan",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "yu liu",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "manjun xiao",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "wenyan su",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "huishan gao",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "jianhua chen",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "hua tan",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "yafei wang",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "renqiang yang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "weiguo zhu",
                "org": "uc berkeley college of chemistry"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "prRq8zVd": {
        "id": "prRq8zVd",
        "title": "Enhancing the photovoltaic performance of triphenylamine based star-shaped molecules by tuning the moiety sequence of their arms in organic solar cells",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "pei zhou",
                "org": "ministry of education"
            },
            {
                "name": "dongfeng dang",
                "org": "ministry of education"
            },
            {
                "name": "qiong wang",
                "org": "ministry of education"
            },
            {
                "name": "xiongwei duan",
                "org": "ministry of education"
            },
            {
                "name": "manjun xiao",
                "org": "ministry of education"
            },
            {
                "name": "qiang tao",
                "org": "ministry of education"
            },
            {
                "name": "hua tan",
                "org": "ministry of education"
            },
            {
                "name": "renqiang yang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "weiguo zhu",
                "org": "ministry of education"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "dNsdCnfz": {
        "id": "dNsdCnfz",
        "title": "Design, synthesis and photovoltaic properties of two \u03c0-bridged cyclopentadithiophene-based polymers",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "chuantao gu",
                "org": "chinese academy of sciences"
            },
            {
                "name": "manjun xiao",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "xichang bao",
                "org": "chinese academy of sciences"
            },
            {
                "name": "liangliang han",
                "org": "chinese academy of sciences"
            },
            {
                "name": "dangqiang zhu",
                "org": "chinese academy of sciences"
            },
            {
                "name": "ning wang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "shuguang wen",
                "org": "chinese academy of sciences"
            },
            {
                "name": "weiguo zhu",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "renqiang yang",
                "org": "chinese academy of sciences"
            }
        ],
        "venue": "",
        "year": 2014
    },
    "OpjlRQHE": {
        "id": "OpjlRQHE",
        "title": "Extending \u03c0-Conjugation System with Benzene: An Effective Method To Improve the Properties of Benzodithiophene-Based Polymer for Highly Efficient Organic Solar Cells",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zhengkun du",
                "org": ""
            },
            {
                "name": "meng qiu",
                "org": ""
            },
            {
                "name": "weichao chen",
                "org": ""
            },
            {
                "name": "manjun xiao",
                "org": ""
            },
            {
                "name": "jiuxing wang",
                "org": ""
            },
            {
                "name": "shuguang wen",
                "org": ""
            },
            {
                "name": "ning wang",
                "org": ""
            },
            {
                "name": "renqiang yang",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Macromolecules",
        "year": 2014
    },
    "OgsOt6MY": {
        "id": "OgsOt6MY",
        "title": "Fluorine substitution enhanced photovoltaic performance of a D\u2013A1\u2013D\u2013A2 copolymer",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "dongfeng dang",
                "org": "ministry of education"
            },
            {
                "name": "weichao chen",
                "org": "chinese academy of sciences"
            },
            {
                "name": "renqiang yang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "weiguo zhu",
                "org": "ministry of education"
            },
            {
                "name": "wendimagegn mammo",
                "org": "addis ababa university"
            },
            {
                "name": "ergang wang",
                "org": "chalmers university of technology"
            }
        ],
        "venue": "Chemical Communications",
        "year": 2013
    },
    "a0b8Tqxm": {
        "id": "a0b8Tqxm",
        "title": "Benzodi(pyridothiophene): a novel acceptor unit for application in A1\u2013A\u2013A1 type photovoltaic small molecules",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jianhua chen",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "manjun xiao",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "linrui duan",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "qiong wang",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "hua tan",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "ning su",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "yu liu",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "renqiang yang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "weiguo zhu",
                "org": "uc berkeley college of chemistry"
            }
        ],
        "venue": "Physical Chemistry Chemical Physics",
        "year": 2015
    },
    "crYyjkQn": {
        "id": "crYyjkQn",
        "title": "Tuning the Isomeric Fused Heteroaromatic Core of Small Donor-Acceptor Molecules to Alter Their Crystalline Nature and Enhance Photovoltaic Performance: Tuning the Aromatic Core of Donor-Acceptor Molecules",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "renqiang yang",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            },
            {
                "name": "yong pei",
                "org": ""
            },
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "qiong wang",
                "org": ""
            },
            {
                "name": "chuncheng yang",
                "org": ""
            },
            {
                "name": "wenjing xiong",
                "org": ""
            },
            {
                "name": "ning su",
                "org": ""
            },
            {
                "name": "jiang fan",
                "org": ""
            },
            {
                "name": "juan zhong",
                "org": ""
            },
            {
                "name": "pei zhou",
                "org": ""
            },
            {
                "name": "manjun xiao",
                "org": ""
            },
            {
                "name": "dongfeng dang",
                "org": ""
            }
        ],
        "venue": "European Journal of Organic Chemistry",
        "year": 2015
    },
    "nCspjgFA": {
        "id": "nCspjgFA",
        "title": "Tuning the Isomeric Fused Heteroaromatic Core of Small Donor\u2013Acceptor Molecules to Alter Their Crystalline Nature and Enhance Photovoltaic Performance",
        "abstract": "",
        "keywords": [
            "energy conversion",
            "thin films"
        ],
        "authors": [
            {
                "name": "dongfeng dang",
                "org": "ministry of education"
            },
            {
                "name": "manjun xiao",
                "org": "chinese academy of sciences"
            },
            {
                "name": "pei zhou",
                "org": "ministry of education"
            },
            {
                "name": "juan zhong",
                "org": "ministry of education"
            },
            {
                "name": "jiang fan",
                "org": "ministry of education"
            },
            {
                "name": "ning su",
                "org": "ministry of education"
            },
            {
                "name": "wenjing xiong",
                "org": "ministry of education"
            },
            {
                "name": "chuncheng yang",
                "org": "ministry of education"
            },
            {
                "name": "qiong wang",
                "org": "ministry of education"
            },
            {
                "name": "yafei wang",
                "org": "ministry of education"
            },
            {
                "name": "yong pei",
                "org": "ministry of education"
            },
            {
                "name": "renqiang yang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "weiguo zhu",
                "org": "ministry of education"
            }
        ],
        "venue": "European Journal of Organic Chemistry",
        "year": 2015
    },
    "7EXinafK": {
        "id": "7EXinafK",
        "title": "Improving photovoltaic properties of linear small molecules with TPA\u2013DPP segment by tuning their frameworks",
        "abstract": "",
        "keywords": [
            "organic solar cells"
        ],
        "authors": [
            {
                "name": "jianhua chen",
                "org": ""
            },
            {
                "name": "manjun xiao",
                "org": ""
            },
            {
                "name": "fanyuan meng",
                "org": ""
            },
            {
                "name": "linrui duan",
                "org": ""
            },
            {
                "name": "hua tan",
                "org": ""
            },
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "renqiang yang",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Synthetic Metals",
        "year": 2015
    },
    "C4Cs0goe": {
        "id": "C4Cs0goe",
        "title": "Efficient Annealing-Free P3HT:PC 61 BM-Based Organic Solar Cells by Using a Novel Solvent Additive without a Halogen or Sulphur Atom",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weiguo zhu",
                "org": ""
            },
            {
                "name": "renqiang yang",
                "org": ""
            },
            {
                "name": "xichang bao",
                "org": ""
            },
            {
                "name": "weichao chen",
                "org": ""
            },
            {
                "name": "liangliang han",
                "org": ""
            },
            {
                "name": "junyi wang",
                "org": ""
            },
            {
                "name": "wenfei shen",
                "org": ""
            },
            {
                "name": "manjun xiao",
                "org": ""
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2015
    },
    "uidJX59K": {
        "id": "uidJX59K",
        "title": "Efficient strategies to improve photovoltaic performance of linear-shape molecules by introducing large planar aryls in molecular center and terminals",
        "abstract": "",
        "keywords": [
            "organic solar cells"
        ],
        "authors": [
            {
                "name": "youming zhang",
                "org": ""
            },
            {
                "name": "manjun xiao",
                "org": ""
            },
            {
                "name": "ning su",
                "org": ""
            },
            {
                "name": "juan zhong",
                "org": ""
            },
            {
                "name": "hua tan",
                "org": ""
            },
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "yong pei",
                "org": ""
            },
            {
                "name": "renqiang yang",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Organic Electronics",
        "year": 2015
    },
    "O67sgRyj": {
        "id": "O67sgRyj",
        "title": "D\u2013A\u2013Ar-type small molecules with enlarged \u03c0-system of phenanthrene at terminal for high-performance solution processed organic solar cells",
        "abstract": "",
        "keywords": [
            "organic solar cells"
        ],
        "authors": [
            {
                "name": "youming zhang",
                "org": ""
            },
            {
                "name": "hua tan",
                "org": ""
            },
            {
                "name": "manjun xiao",
                "org": ""
            },
            {
                "name": "xichang bao",
                "org": ""
            },
            {
                "name": "qiang tao",
                "org": ""
            },
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "renqiang yang",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Organic Electronics",
        "year": 2014
    },
    "HL4bUhKS": {
        "id": "HL4bUhKS",
        "title": "Manipulating backbone structure with various conjugated spacers to enhance photovoltaic performance of D-A-type two-dimensional copolymerse",
        "abstract": "",
        "keywords": [
            "polymer solar cells"
        ],
        "authors": [
            {
                "name": "dongfeng dang",
                "org": ""
            },
            {
                "name": "manjun xiao",
                "org": ""
            },
            {
                "name": "pei zhou",
                "org": ""
            },
            {
                "name": "junwei shi",
                "org": ""
            },
            {
                "name": "qiang tao",
                "org": ""
            },
            {
                "name": "hua tan",
                "org": ""
            },
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "xichang bao",
                "org": ""
            },
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "ergang wang",
                "org": ""
            },
            {
                "name": "renqiang yang",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Organic Electronics",
        "year": 2014
    },
    "i6WcIwVA": {
        "id": "i6WcIwVA",
        "title": "Benzodithiophene-based two-dimensional polymers with extended conjugated thienyltriphenylamine substituents for high-efficiency polymer solar cells",
        "abstract": "",
        "keywords": [
            "two dimensional",
            "polymer solar cells"
        ],
        "authors": [
            {
                "name": "qunping fan",
                "org": ""
            },
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "pingao yang",
                "org": ""
            },
            {
                "name": "wenyan su",
                "org": ""
            },
            {
                "name": "manjun xiao",
                "org": ""
            },
            {
                "name": "jianhua chen",
                "org": ""
            },
            {
                "name": "min li",
                "org": ""
            },
            {
                "name": "xiangdong wang",
                "org": ""
            },
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "hua tan",
                "org": ""
            },
            {
                "name": "renqiang yang",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Organic Electronics",
        "year": 2015
    },
    "zGFTYWko": {
        "id": "zGFTYWko",
        "title": "Donor\u2013acceptor copolymers based on benzo[1,2- b :4,5- b \u2032]dithiophene and pyrene-fused phenazine for high-performance polymer solar cells",
        "abstract": "",
        "keywords": [
            "polymer solar cells"
        ],
        "authors": [
            {
                "name": "qunping fan",
                "org": ""
            },
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "manjun xiao",
                "org": ""
            },
            {
                "name": "hua tan",
                "org": ""
            },
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "wenyan su",
                "org": ""
            },
            {
                "name": "delong yu",
                "org": ""
            },
            {
                "name": "renqiang yang",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Organic Electronics",
        "year": 2014
    },
    "tThmYTYX": {
        "id": "tThmYTYX",
        "title": "Acceptor-donor-acceptor small molecules containing benzo[1,2- b :4,5- b ']dithiophene and rhodanine units for solution processed organic solar cells",
        "abstract": "",
        "keywords": [
            "bulk heterojunction",
            "organic solar cells",
            "small molecule"
        ],
        "authors": [
            {
                "name": "qunping fan",
                "org": ""
            },
            {
                "name": "min li",
                "org": ""
            },
            {
                "name": "pingao yang",
                "org": ""
            },
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "manjun xiao",
                "org": ""
            },
            {
                "name": "xiangdong wang",
                "org": ""
            },
            {
                "name": "hua tan",
                "org": ""
            },
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "renqiang yang",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2015
    },
    "KW22FT4w": {
        "id": "KW22FT4w",
        "title": "Synthesis and photovoltaic performance of DPP-based small molecules with tunable energy levels by altering the molecular terminals",
        "abstract": "",
        "keywords": [
            "small molecules",
            "bulk heterojunction",
            "organic solar cells"
        ],
        "authors": [
            {
                "name": "delong yu",
                "org": ""
            },
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "manjun xiao",
                "org": ""
            },
            {
                "name": "qunping fan",
                "org": ""
            },
            {
                "name": "wenyan su",
                "org": ""
            },
            {
                "name": "xiao li",
                "org": ""
            },
            {
                "name": "hua tan",
                "org": ""
            },
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "renqiang yang",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2016
    },
    "QYNRxBFY": {
        "id": "QYNRxBFY",
        "title": "Influence of the fused hetero-aromatic centers on molecular conformation and photovoltaic performance of solution-processed organic solar cells",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "dongfeng dang",
                "org": "ministry of education"
            },
            {
                "name": "jiang fan",
                "org": "ministry of education"
            },
            {
                "name": "xiangdong wang",
                "org": "ministry of education"
            },
            {
                "name": "manjun xiao",
                "org": "ministry of education"
            },
            {
                "name": "junwei shi",
                "org": "ministry of education"
            },
            {
                "name": "pei zhou",
                "org": "ministry of education"
            },
            {
                "name": "xiongwei duan",
                "org": "ministry of education"
            },
            {
                "name": "gangtie lei",
                "org": "ministry of education"
            },
            {
                "name": "yu liu",
                "org": "ministry of education"
            },
            {
                "name": "weiguo zhu",
                "org": "ministry of education"
            }
        ],
        "venue": "New Journal of Chemistry",
        "year": 2015
    },
    "XDbudxyg": {
        "id": "XDbudxyg",
        "title": "Significantly increasing open-circuit voltage of the benzo[1,2- b :4,5-b\u2032]dithiophene- alt -5,8-dithienyl-quinoxaline copolymers based PSCs by appending dioctyloxy chains at 6,7-positions of quinoxaline",
        "abstract": "",
        "keywords": [
            "polymer solar cells"
        ],
        "authors": [
            {
                "name": "wenyan su",
                "org": ""
            },
            {
                "name": "manjun xiao",
                "org": ""
            },
            {
                "name": "qunping fan",
                "org": ""
            },
            {
                "name": "juan zhong",
                "org": ""
            },
            {
                "name": "jianhua chen",
                "org": ""
            },
            {
                "name": "dongfeng dang",
                "org": ""
            },
            {
                "name": "junwei shi",
                "org": ""
            },
            {
                "name": "wenjin xiong",
                "org": ""
            },
            {
                "name": "xongwei duan",
                "org": ""
            },
            {
                "name": "hua tan",
                "org": ""
            },
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Organic Electronics",
        "year": 2015
    },
    "JIEXoHKd": {
        "id": "JIEXoHKd",
        "title": "Synthesis and photovoltaic properties of two star-shaped molecules involving phenylquinoxaline as core and triphenylamine and thiophene units as arms",
        "abstract": "",
        "keywords": [
            "organic solar cell"
        ],
        "authors": [
            {
                "name": "qunping fan",
                "org": ""
            },
            {
                "name": "jiaojiao cui",
                "org": ""
            },
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "wenyan su",
                "org": ""
            },
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "hua tan",
                "org": ""
            },
            {
                "name": "delong yu",
                "org": ""
            },
            {
                "name": "huishan gao",
                "org": ""
            },
            {
                "name": "xianping deng",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Synthetic Metals",
        "year": 2015
    },
    "h95F2MRY": {
        "id": "h95F2MRY",
        "title": "Synthesis of multi-armed small molecules with planar terminals and their application in organic solar cells",
        "abstract": "Abstract   Bi-armed Cz(BT-T-3Cz) 2 , tri-armed TPA(BT-T-3Cz) 3  and tetra-armed SF(BT-T-3Cz) 4  with planar terminals were designed, in which carbazole, triphenylamine and spiro-fluorene units were employed as the electron-rich core, respectively, and benzothiadiazole units were introduced as the electron-deficient arms. As displayed, when the electron-deficient arms in molecules increase, improved thermal properties and increased extinction coefficient were obtained. Also as anticipated, the spatial configurations of SMs could affect their photovoltaic performance significantly. The linear Cz(BT-T-3Cz) 2 -based solar cells exhibited a PCE value of 3.0%, however, tri-armed TPA(BT-T-3Cz) 3  and tetra-armed SF(BT-T-3Cz) 4  displayed better photovoltaic properties with the PCE values up to 5.25% and 4.37% in their corresponding devices, respectively, indicating that altering the spatial configurations in molecules is an efficient method to enhance their photovoltaic performance in OSCs.",
        "keywords": "",
        "authors": [
            {
                "name": "Dongfeng Dang",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Pei Zhou",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Manjun Xiao",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Manjun Xiao",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Renqiang Yang",
                "org": "Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, PR China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2016
    },
    "TmCXRXF1": {
        "id": "TmCXRXF1",
        "title": "Strain-released method to enhance the photovoltaic performance in solution-processed organic solar cells",
        "abstract": "Abstract   To release the steric-strain in largely fused molecular backbone and achieve the much planar molecules for efficient organic solar cells, a facile method was proposed by dividing the rigidly fused dibenzosexithiophene (DBST) units in FT3 with large molecular skeletons to two smaller building blocks to construct the electron donor-acceptor type compound FT4. As observed, much improved molecular co-planarity was achieved for FT4 in contrast to that of FT3, then leading to the higher charge carrier mobilities up to 6.7\u00a0\u00d7\u00a010 \u22124  cm 2 V \u22121 s \u22121  by SCLC method. Meanwhile, FT4-based BHJ solar cells also exhibited much enhanced photovoltaic performance with the maximum PCE value of 3.07% and higher  J  sc  value of 8.23\u00a0mA/cm 2 , which is only 2.13% and 5.67\u00a0mA/cm 2  for FT3-based solar cells. The results here indicated that the strain-released method, especially in the highly fused molecules, is beneficial to further improve their co-planarity, then leading to the high charge carrier mobilities and much enhanced photovoltaic performance in solar cells.",
        "keywords": "",
        "authors": [
            {
                "name": "Ying Zhi",
                "org": "School of Science, Xi'an Jiao Tong University, Xi'an 710049, PR China"
            },
            {
                "name": "Yanzi Xu",
                "org": "School of Science, Xi'an Jiao Tong University, Xi'an 710049, PR China"
            },
            {
                "name": "Xichang Bao",
                "org": "Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, PR China"
            },
            {
                "name": "Renqiang Yang",
                "org": ""
            },
            {
                "name": "Weiguo Zhu",
                "org": "School of Materials Science and Engineering, Changzhou University, Changzhou 213164, PR China"
            },
            {
                "name": "Dongfeng Dang",
                "org": "School of Science, Xi'an Jiao Tong University, Xi'an 710049, PR China"
            },
            {
                "name": "Lingjie Meng",
                "org": "School of Science, Xi'an Jiao Tong University, Xi'an 710049, PR China"
            },
            {
                "name": "Ruijun Cao",
                "org": "School of Science, Xi'an Jiao Tong University, Xi'an 710049, PR China"
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2017
    },
    "geOsmpIX": {
        "id": "geOsmpIX",
        "title": "Improving Photovoltaic Performance of the Linear A-Ar-A-type Small Molecules with Diketopyrropyrrole Arms by Tuning the Linkage Position of the Anthracene Core",
        "abstract": "Two isomeric A-Ar-A-type small molecules of DPP2An(9,10) and DPP2An(2,6), were synthesized with two acceptor arms of diketopyrropyrroles (DPP) and a planar aryl hydrocarbon core of the different substituted anthracene (An), respectively. Their thermal stability, crystallinity, optoelectronic, and photovoltaic performances were investigated. Significantly red-shifted absorption profile and higher HOMO level were observed for the DPP2An(2,6) with 2,6-substituted anthracene relative to the DPP2An(9,10) with 9,10-substituted anthracene, as the former exhibited better planarity and a larger conjugate system. As a result, the solution-processing solar cells based on DPP2An(2,6) and PC71BM (w/w,1:1) displayed remarkably increased power conversion efficiency of 5.44% and short-circuit current density (Jsc) of 11.90 mA/cm2 under 1% 1,8-diiodooctane additive. The PCE and Jsc values were 3.7 and 2.9 times those of the optimized DPP2An(9,10)-based cells, respectively. This work demonstrates that changing the linkage ...",
        "keywords": "",
        "authors": [
            {
                "name": "Xiongwei Duan",
                "org": ""
            },
            {
                "name": "Manjun Xiao",
                "org": ""
            },
            {
                "name": "Jianhua Chen",
                "org": ""
            },
            {
                "name": "Xiangdong Wang",
                "org": ""
            },
            {
                "name": "Wenhong Peng",
                "org": ""
            },
            {
                "name": "Linrui Duan",
                "org": ""
            },
            {
                "name": "Hua Tan",
                "org": ""
            },
            {
                "name": "Gangtie Lei",
                "org": ""
            },
            {
                "name": "Renqiang Yang",
                "org": ""
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            }
        ],
        "venue": "ACS Applied Materials & Interfaces",
        "year": 2015
    },
    "wuyH75W9": {
        "id": "wuyH75W9",
        "title": "Photovoltaic Small Molecules of TPA(FxBT-T-Cz)3: Tuning Open-Circuit Voltage over 1.0 V for Their Organic Solar Cells by Increasing Fluorine Substitution",
        "abstract": "To simultaneously improve both open-circuit voltage (Voc) and short-circuit current density (Jsc) for organic solar cells, a novel D(A-\u03c0-Ar)3 type of photovoltaic small molecules of TPA(FxBT-T-3Cz)3 was designed and synthesized, which contain central triphenylamine (TPA), terminal carbazole (Cz), armed fluorine-substituted benzothiadiazole (FxBT, where x = 1 or 2), and bridged thiophene (T) units. A narrowed ultraviolet\u2013visible absorption and a decreasing highest occupied molecular orbital energy level were observed from TPA(F1BT-T-3Cz)3 to TPA(F2BT-T-3Cz)3 with increasing fluorine substitution. However, the TPA(F2BT-T-3Cz)3/PC71BM-based solar devices showed a rising Voc of 1.01 V and an enhanced Jsc of 10.84 mA cm\u20132 as well as a comparable power conversion efficiency of 4.81% in comparison to the TPA(F1BT-T-3Cz)3/PC71BM-based devices. Furthermore, in comparison to the parent TPA(BT-T-3Cz)3 molecule without fluorine substitution, the fluorine-substituted TPA(FxBT-T-3Cz)3 molecules exhibited significantly ...",
        "keywords": "",
        "authors": [
            {
                "name": "Qiong Wang",
                "org": ""
            },
            {
                "name": "Linrui Duan",
                "org": ""
            },
            {
                "name": "Qiang Tao",
                "org": ""
            },
            {
                "name": "Wenhong Peng",
                "org": ""
            },
            {
                "name": "Jianhua Chen",
                "org": ""
            },
            {
                "name": "Hua Tan",
                "org": ""
            },
            {
                "name": "Renqiang Yang",
                "org": ""
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            }
        ],
        "venue": "ACS Applied Materials & Interfaces",
        "year": 2016
    },
    "c20LzpZ8": {
        "id": "c20LzpZ8",
        "title": "Tuning the central fused ring and terminal units to improve the photovoltaic performance of Ar(A\u2013D)2 type small molecules in solution-processed organic solar cells",
        "abstract": "Low band-gap A\u2013Ar\u2013A and Ar(A\u2013D)2 type small molecules (SMs) of DPP2Py, ThDPP2Py and TPADPP2Py were designed and synthesized, in which pyrene (Py) and diketopyrrolopyrrole (DPP) were respectively used as central aryl (Ar) and arm acceptor (A) units and 2-octylthiophene (Th) and triphenylamine (TPA) were employed as terminal donor (D) units. The effects of the central aryl and terminal units on optical, electrochemical, morphological and photovoltaic properties were primarily investigated. Compared to the reported analogues of DPP2Ar, in which Ar respectively represents 1,4-phenylene, 2,6-naphthalene and 2,6-anthracene, both DPP2Py and ThDPP2Py showed significantly improved photovoltaic performance in solution-processed organic solar cells. Furthermore, ThDPP2Py exhibited better photovoltaic performance than DPP2Py in these cells under optimized processing conditions. An improved power conversion efficiency (PCE) of 5.88% with a short current density (Jsc) of 15.35 mA cm\u22122 and a fill factor (FF) of 57.89% was obtained for the ThDPP2Py based OPV cells. Our research result demonstrates that properly extending the central aryl ring and appending terminal units in A\u2013Ar\u2013A type SMs can significantly improve the photovoltaic performance of Ar(A\u2013D)2 type SMs.",
        "keywords": "",
        "authors": [
            {
                "name": "Jianhua Chen",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Linrui Duan",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Linrui Duan",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Manjun Xiao",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Qiong Wang",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Bin Liu",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Hao Xia",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Renqiang Yang",
                "org": "Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences,Qingdao 266101,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            }
        ],
        "venue": "Journal of Materials Chemistry",
        "year": 2016
    },
    "HiP9TG7d": {
        "id": "HiP9TG7d",
        "title": "A Facile Method to Enhance Photovoltaic Performance of Benzodithiophene\u2010Isoindigo Polymers by Inserting Bithiophene Spacer",
        "abstract": "",
        "keywords": [
            "energy conversion",
            "photochemistry",
            "materials",
            "fullerenes",
            "energy"
        ],
        "authors": [
            {
                "name": "zaifei ma",
                "org": "linkoping university"
            },
            {
                "name": "dongfeng dang",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "zheng tang",
                "org": "linkoping university"
            },
            {
                "name": "desta gedefaw",
                "org": "linkoping university"
            },
            {
                "name": "jonas bergqvist",
                "org": "linkoping university"
            },
            {
                "name": "weiguo zhu",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "wendimagegn mammo",
                "org": "addis ababa university"
            },
            {
                "name": "mats andersson",
                "org": "chalmers university of technology"
            },
            {
                "name": "olle inganas",
                "org": "linkoping university"
            },
            {
                "name": "fengling zhang",
                "org": "linkoping university"
            },
            {
                "name": "ergang wang",
                "org": "chalmers university of technology"
            }
        ],
        "venue": "",
        "year": 2014
    },
    "sYXTlNEE": {
        "id": "sYXTlNEE",
        "title": "Significantly Enhancing the Efficiency of a New Light\u2010Harvesting Polymer with Alkylthio naphthyl Substituents Compared to Their Alkoxyl Analogs",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Gongyue Huang",
                "org": "CAS Key Laboratory of Bio\u2010based Materials Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266101 P. R. China"
            },
            {
                "name": "Gongyue Huang",
                "org": "CAS Key Laboratory of Bio\u2010based Materials Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266101 P. R. China"
            },
            {
                "name": "Jun Zhang",
                "org": "CAS Key Laboratory of Bio\u2010based Materials Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266101 P. R. China"
            },
            {
                "name": "Jun Zhang",
                "org": "CAS Key Laboratory of Bio\u2010based Materials Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266101 P. R. China"
            },
            {
                "name": "Nergui Uranbileg",
                "org": "CAS Key Laboratory of Bio\u2010based Materials Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266101 P. R. China"
            },
            {
                "name": "Weichao Chen",
                "org": "CAS Key Laboratory of Bio\u2010based Materials Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266101 P. R. China"
            },
            {
                "name": "Weichao Chen",
                "org": "CAS Key Laboratory of Bio\u2010based Materials Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266101 P. R. China"
            },
            {
                "name": "Huanxiang Jiang",
                "org": "CAS Key Laboratory of Bio\u2010based Materials Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266101 P. R. China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry Xiangtan University Xiangtan 411105 P. R. China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "School of Materials Science and Engineering Changzhou University Changzhou 213164 P. R. China"
            },
            {
                "name": "Renqiang Yang",
                "org": "CAS Key Laboratory of Bio\u2010based Materials Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266101 P. R. China"
            }
        ],
        "venue": "Advanced Energy Materials",
        "year": 2018
    },
    "gDkWjre2": {
        "id": "gDkWjre2",
        "title": "The A-D-A type small molecules with isomeric benzodithiophene cores: Synthesis and influence of isomers on photoelectronic properties",
        "abstract": "Abstract   Two isomeric A-D-A type small molecules (SMs) of BDTx-2TVTDPP and BDTy-2TVTDPP were designed and synthesized, which contain different donor (D) center of substituted benzodithiophene (BDT) in backbone, and the same acceptor (A) and bridged units of diketopyrrolopyrrole (DPP) and thienylenevinylenethiophene (TVT), respectively. Their thermal stability, crystallinity, film morphology and photoelectronic properties were primarily investigated. It was found the BDTx-2TVTDPP with 2,6-substituted BDT unit exhibited a pronouncedly red-shifted and enhanced absorption in solid state and a better crystallinity. In contrast, the BDTy-2TVTDPP with 4,8-substituted BDT unit in backbone exhibited better solubility, deeper HOMO energy level and more smoothed blend film morphology. As a result, the solution-processing BDTy-2TVTDPP based solar cells displayed better photovoltaic properties than the BDTx-2TVTDPP based ones using fullerene derivatives (PC 61 BM or PC 71 BM) as electron acceptor. A power conversion efficiency maximum of 2.85% was obtained in the BDTy-2TVTDPP based cells, which is 1.8 times that of the BDTx-2TVTDPP based cells. This study indicates that changing the substituted positions of BDT is available to significantly improve photovoltaic properties for its resulting SMs.",
        "keywords": "",
        "authors": [
            {
                "name": "Linrui Duan",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan, 411105, China"
            },
            {
                "name": "Jianhua Chen",
                "org": "School of Materials Science and Engineering, Jiangsu Collaboration Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou, 213164, China"
            },
            {
                "name": "Bin Liu",
                "org": "School of Materials Science and Engineering, Jiangsu Collaboration Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou, 213164, China"
            },
            {
                "name": "Xiangdong Wang",
                "org": "School of Materials Science and Engineering, Jiangsu Collaboration Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou, 213164, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "School of Materials Science and Engineering, Jiangsu Collaboration Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou, 213164, China"
            },
            {
                "name": "Renqiang Yang",
                "org": "Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, China"
            }
        ],
        "venue": "Tetrahedron",
        "year": 2017
    },
    "XdEFbVB4": {
        "id": "XdEFbVB4",
        "title": "Improving self-assembly behavior and photovoltaic performance of the indacenodithiophene-based small molecules via increasing dipole moment of the terminal group",
        "abstract": "Abstract   Two small molecules (SMs) of IDT(BT-T3Cz) 2  and IDT(DFBT-T3Cz) 2  with a D(A-Ar) 2  framework were designed and synthesized as a novel class of photovoltaic donor materials, which contain a donor (D) core of indacenodithiophene (IDT), two acceptor (A) arms of benzothiadiazole (BT) or fluorinated benzothiadiazole (DFBT), and two terminals of 3-carbazole (Cz). The impacts of 3-carbazole and fluorine atom on the optical absorption, electrochemical property, hole mobility, film morphology, and solar cell performance were primarily studied. A broad absorption profile in a range of 350\u2013750\u00a0nm and a low HOMO energy level around\u00a0\u22125.30\u00a0eV were observed for both SMs. In comparison to the reported SM of IDT(BT-Th 2 ) 2  with 5-alkyl-thiophene terminal, both SMs with 3-carbazole terminal exhibited stronger molecular packing and better self-assembly behavior owing to the increasing dipole moment of carbazole. Furthermore, the IDT(DFBT-T3Cz) 2  showed a higher power conversion efficiency (PCE) of 5.99% with an increasing fill factor ( FF ) of 59.6% than IDT(BT-T3Cz) 2  in their solar cells under the illumination of AM 1.5G at 100\u00a0mWcm \u22122 . To the best of our knowledge, this is one of the highest PCE value reported for the IDT based SMs in solution-processed bulk heterojunction solar cells. And this work provides an efficient strategy to improve self-assembly behavior and photovoltaic performance via increasing dipole moment of the terminal groups.",
        "keywords": "",
        "authors": [
            {
                "name": "Qiang Tao",
                "org": "School of Materials Science and Engineering, Jiangsu Collaboration Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou 213164, PR China"
            },
            {
                "name": "Manjun Xiao",
                "org": "Institute of Polymer Optoelectronic Materials and Devices, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, PR China"
            },
            {
                "name": "Mengbing Zhu",
                "org": ""
            },
            {
                "name": "Lin Shao",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Zhaoyang Sui",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Pu Wang",
                "org": ""
            },
            {
                "name": "Gongyue Huang",
                "org": "School of Materials Science and Engineering, Jiangsu Collaboration Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou 213164, PR China"
            },
            {
                "name": "Yong Pei",
                "org": ""
            },
            {
                "name": "Weiguo Zhu",
                "org": "School of Materials Science and Engineering, Jiangsu Collaboration Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou 213164, PR China"
            },
            {
                "name": "Fei Huang",
                "org": "Institute of Polymer Optoelectronic Materials and Devices, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, PR China"
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2017
    },
    "lqrZDZt3": {
        "id": "lqrZDZt3",
        "title": "Improved photovoltaic performance of D\u2013A\u2013D-type small molecules with isoindigo and pyrene units by inserting different \u03c0-conjugated bridge",
        "abstract": "Abstract   Two novel D-\u03c0\u2013A\u2013\u03c0-D-type small molecules (SMs) of IID(Ac\u2013Py) 2  and IID(Th\u2013Py) 2  were synthesized and characterized, in which isoindigo (IID), acetylene (Ac) or thiophene (Th), and pyrene (Py) were used as the acceptor (A) core, extended \u03c0-bridges, and donor (D) terminal units, respectively. Significantly improved photophysical and photovoltaic performances were observed for both SMs containing extended \u03c0-bridge in comparison with those for their parent D\u2013A\u2013D type molecule of IID(Py) 2 . Compared to IID(Ac\u2013Py) 2 , IID(Th\u2013Py) 2  shows a better photovoltaic performance due to broader absorption, deeper HOMO levels (\u22125.44\u00a0eV) and better morphology of the devices. A maximum power conversion efficiency (PCE) of 1.88% with a short-circuit current density ( J  sc ) of 6.90\u00a0mA\u00a0cm \u22122  was obtained in the IID(Th\u2013Py) 2 /PC 71 BM-based solar cells, which is 2.35 times the value of IID(Ac\u2013Py) 2 -based cells. Particularly, the IID(Th\u2013Py) 2 /PC 61 BM-based device exhibited a  V  oc  value up to 1.01\u00a0V, which is 0.27\u00a0V and 0.12\u00a0V higher than IID(Py) 2 /and IID(Ac\u2013Py) 2 /PC 61 BM-based devices, respectively. To our best knowledge, the  V  oc  of 1.01\u00a0V is among the highest values in literature\u00a0for solution processed SMs OSCs without any post processing.",
        "keywords": "",
        "authors": [
            {
                "name": "Delong Yu",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Yu Liu",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Qunping Fan",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Manjun Xiao",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Renqiang Yang",
                "org": "Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            }
        ],
        "venue": "Tetrahedron",
        "year": 2016
    },
    "snd3h2Ho": {
        "id": "snd3h2Ho",
        "title": "Improving photovoltaic properties of the linear A-Ar-A type small molecules with rhodanine by extending arylene core",
        "abstract": "Abstract   In order to efficiently tune photovoltaic performance, a series of linear A-Ar-A type small molecules (SMs) of (DRCN3T) 2 Ar were designed and synthesized, which contain the same terminal of 2-(1,1-dicyanomethylene) rhodanine (DRCN) and \u03c0-bridged space of 5-vinyl-trithiophene (3T), but different central arylene (Ar) unit, respectively. Significantly extending film absorption and increasing hole mobility were obtained in these SMs with enlarging Ar units from phenylene (Ph), naphthylene (Nap) to anthrylene (Ant). As a result, photovoltaic properties were remarkably improved in these SM/PC 71 BM based solution-processing organic solar cells (OSCs) by enlarging Ar units in (DRCN3T) 2 Ar. The highest power conversion efficiency of 5.15% with a short-circuit current density of 11.34\u00a0mA\u00a0cm \u22122  was obtained in the (DRCN3T) 2 Ant based device, which is three times of that in the (DRCN3T) 2 Ph-based device. Our work further indicates that properly extending Ar core could be beneficial to improve photovoltaic properties for the A-Ar-A type SMs.",
        "keywords": "",
        "authors": [
            {
                "name": "Bin Liu",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, PR China"
            },
            {
                "name": "Linrui Duan",
                "org": ""
            },
            {
                "name": "Jianhua Chen",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, PR China"
            },
            {
                "name": "Xiongwei Duan",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, PR China"
            },
            {
                "name": "Ting Lei",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, PR China"
            },
            {
                "name": "Yufeng Cai",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, PR China"
            },
            {
                "name": "Qiong Wang",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, PR China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, PR China"
            },
            {
                "name": "Renqiang Yang",
                "org": "Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, PR China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, PR China"
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2017
    },
    "dcnC20mp": {
        "id": "dcnC20mp",
        "title": "High-efficiency saturated red emission from binuclear cyclo-metalated platinum complex containing 5-(4-octyloxyphenyl)-1,3,4-oxadiazole-2-thiol ancillary ligand in PLEDs",
        "abstract": "A novel red-emitting binuclear platinum complex (dfppy)2Pt2(C8OXT)2 was synthesized and characterized,in which dfppy represents 2-(4',6'-difluorophenyl)pyridinato unit and C8OXT is abbreviated for 5-(4-octyloxyphenyl)-1,3,4-oxadiazole-2-thiol as a bridging ancillary ligand.Its photophysical,electrochemical and electroluminescent characteristics were primarily studied.The made single-emissive-layer (SEL) polymer light-emitting devices using (dfppy)2Pt2(C8OXT)2 as emitter exhibited a saturated red emission peaked at 620nm.The best device performances were obtained in the device at 8wt% dopant concentration,with a maximum external quantum efficiency of 8.4%,a current efficiency of 4.2cd/A and brightness of 3228cd/m2.This work provides an effective approach to obtain high-efficiency red emission through construction of new binuclear platinum complex and its doped SEL devices.",
        "keywords": [
            "polymer light-emitting devices",
            "electroluminescence",
            "binuclear platinum complexes",
            "red emission",
            "oxadiazole"
        ],
        "authors": [
            {
                "name": "junting yu",
                "org": "xiangtan university"
            },
            {
                "name": "xiugang wu",
                "org": "xiangtan university"
            },
            {
                "name": "hua tan",
                "org": "xiangtan university"
            },
            {
                "name": "yu liu",
                "org": "xiangtan university"
            },
            {
                "name": "yafei wang",
                "org": "xiangtan university"
            },
            {
                "name": "meixiang zhu",
                "org": "xiangtan university"
            },
            {
                "name": "weiguo zhu",
                "org": "xiangtan university"
            }
        ],
        "venue": "\u4e2d\u56fd\u79d1\u5b66:\u5316\u5b66(\u82f1\u6587\u7248)",
        "year": 2013
    },
    "ZKF1bQaj": {
        "id": "ZKF1bQaj",
        "title": "Synthesis and photovoltaic performance of N-dioctylmethyl-2,7-carbazole-alt-5,7-bis(thiophen-2-yl)-2,3-biphenylthieno[3,4-b] pyrazine copolymeric derivatives appending various donor units in phenyl moieties",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jianmin li",
                "org": "xiangtan university"
            },
            {
                "name": "hua tan",
                "org": "xiangtan university"
            },
            {
                "name": "fanyuan meng",
                "org": "xiangtan university"
            },
            {
                "name": "wenhong peng",
                "org": "xiangtan university"
            },
            {
                "name": "yafei wang",
                "org": "xiangtan university"
            },
            {
                "name": "yu liu",
                "org": "xiangtan university"
            },
            {
                "name": "weiguo zhu",
                "org": "xiangtan university"
            }
        ],
        "venue": "Science China-chemistry",
        "year": 2015
    },
    "zLnfN9sF": {
        "id": "zLnfN9sF",
        "title": "Luminescent metallomesogens based on platinum complex containing triphenylene unit",
        "abstract": "",
        "keywords": [
            "luminescence"
        ],
        "authors": [
            {
                "name": "junwei shi",
                "org": ""
            },
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "manjun xiao",
                "org": ""
            },
            {
                "name": "ping zhong",
                "org": ""
            },
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "hua tan",
                "org": ""
            },
            {
                "name": "meixiang zhu",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Tetrahedron",
        "year": 2015
    },
    "08w3itFF": {
        "id": "08w3itFF",
        "title": "Tuning the oxidation potential of 2-phenylpyridine-based iridium complexes to improve the performance of bluish and white OLEDs",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yafei wang",
                "org": "university of birmingham"
            },
            {
                "name": "ning sun",
                "org": "chinese academy of sciences"
            },
            {
                "name": "basile f e curchod",
                "org": "stanford university"
            },
            {
                "name": "louise male",
                "org": "university of birmingham"
            },
            {
                "name": "dongge ma",
                "org": "chinese academy of sciences"
            },
            {
                "name": "jiang fan",
                "org": "ministry of education"
            },
            {
                "name": "yu liu",
                "org": "ministry of education"
            },
            {
                "name": "weiguo zhu",
                "org": "ministry of education"
            },
            {
                "name": "etienne baranoff",
                "org": "university of birmingham"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "kcC06Ctb": {
        "id": "kcC06Ctb",
        "title": "A Novel Benzo[1,2- b :4,5- b \u2032]dithiophene-Based Conjugated Polymer with a Pendant Diketopyrrolopyrrole Unit for High-Performance Solar Cells",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "junting yu",
                "org": ""
            },
            {
                "name": "baofeng zhao",
                "org": ""
            },
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            },
            {
                "name": "hongbin wu",
                "org": ""
            },
            {
                "name": "yong cao",
                "org": ""
            },
            {
                "name": "hua tan",
                "org": ""
            },
            {
                "name": "xianping deng",
                "org": ""
            }
        ],
        "venue": "Macromolecules",
        "year": 2013
    },
    "tedvf27n": {
        "id": "tedvf27n",
        "title": "Novel iridium complexes containing alkylfluorene functionalized picolinic acid ancillary ligand: Synthesis, optophysics and electroluminescence properties",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "junting yu",
                "org": ""
            },
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "xianping deng",
                "org": ""
            },
            {
                "name": "hua tan",
                "org": ""
            },
            {
                "name": "zhiyong zhang",
                "org": ""
            },
            {
                "name": "meixiang zhu",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Journal of Organometallic Chemistry",
        "year": 2014
    },
    "CSwModeD": {
        "id": "CSwModeD",
        "title": "Star-Shaped Trinuclear Cyclometalated Platinum(II) Complexes as Single-Component Emitters in White-Emitting PLEDs",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weiguo zhu",
                "org": ""
            },
            {
                "name": "gangtie lei",
                "org": ""
            },
            {
                "name": "qing chen",
                "org": ""
            },
            {
                "name": "juan he",
                "org": ""
            },
            {
                "name": "jian luo",
                "org": ""
            },
            {
                "name": "zhiyong zhang",
                "org": ""
            },
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "danyan shi",
                "org": ""
            }
        ],
        "venue": "Chemistry-an Asian Journal",
        "year": 2012
    },
    "HLyOu0pM": {
        "id": "HLyOu0pM",
        "title": "Synthesis and Optoelectronic Characterization of a Monochromic Red-Emitting Europium(III) Complex Containing Triphenylamine-Functionalized Phenanthroline",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "junbiao peng",
                "org": ""
            },
            {
                "name": "chun li",
                "org": ""
            },
            {
                "name": "meixiang zhu",
                "org": ""
            },
            {
                "name": "haipeng guo",
                "org": ""
            },
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "yong cao",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Journal of Physical Chemistry C",
        "year": 2011
    },
    "AoBs2Fqp": {
        "id": "AoBs2Fqp",
        "title": "Synthesis and optoelectronic properties of novel fluorene-bridged dinuclear cyclometalated iridium (III) complex with A\u2013D\u2013A framework in the single-emissive-layer WOLEDs",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "keqi he",
                "org": ""
            },
            {
                "name": "xiangdong wang",
                "org": ""
            },
            {
                "name": "junting yu",
                "org": ""
            },
            {
                "name": "haigang jiang",
                "org": ""
            },
            {
                "name": "guangshan xie",
                "org": ""
            },
            {
                "name": "hua tan",
                "org": ""
            },
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "dongge ma",
                "org": ""
            },
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Organic Electronics",
        "year": 2014
    },
    "2fVOleop": {
        "id": "2fVOleop",
        "title": "Synthesis and properties of novel near-infrared dye based on BODIPY and diketopyrrolopyrrole units",
        "abstract": "",
        "keywords": [
            "luminescence"
        ],
        "authors": [
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "jianhua chen",
                "org": ""
            },
            {
                "name": "yuanhui zhen",
                "org": ""
            },
            {
                "name": "haigang jiang",
                "org": ""
            },
            {
                "name": "gui yu",
                "org": ""
            },
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "etienne baranoff",
                "org": ""
            },
            {
                "name": "hua tan",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Materials Letters",
        "year": 2015
    },
    "3kCruoac": {
        "id": "3kCruoac",
        "title": "Improved photovoltaic performance of two-dimensional low band-gap conjugated polymers with thieno[3,2-b]thiophene and diketopyrrolopyrrole units by altering pendent position of conjugated side chain",
        "abstract": "",
        "keywords": [
            "polymer solar cells",
            "hole mobility"
        ],
        "authors": [
            {
                "name": "dongfeng dang",
                "org": ""
            },
            {
                "name": "pei zhou",
                "org": ""
            },
            {
                "name": "qing peng",
                "org": ""
            },
            {
                "name": "keqi he",
                "org": ""
            },
            {
                "name": "haigang jiang",
                "org": ""
            },
            {
                "name": "pingao yang",
                "org": ""
            },
            {
                "name": "hua tan",
                "org": ""
            },
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "gangtie lei",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2014
    },
    "hQhKLMJp": {
        "id": "hQhKLMJp",
        "title": "Bipolar-transporting dinuclear europium(III) complexes involving carbazole and oxadiazole units: Synthesis, photophysical and electroluminescent properties",
        "abstract": "",
        "keywords": [
            "electroluminescence"
        ],
        "authors": [
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "jianyu wang",
                "org": ""
            },
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "zhiyong zhang",
                "org": ""
            },
            {
                "name": "meixiang zhu",
                "org": ""
            },
            {
                "name": "gangtie lei",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2012
    },
    "Sxs8UtvU": {
        "id": "Sxs8UtvU",
        "title": "Enhanced photovoltaic properties of di(dodecylthiophene)- alt -2,3-di(3-octoxylphenyl)-5,8-dithieno[3,2- b ]thiophene 6,7-difluoroquinoxaline copolymer by fluorination",
        "abstract": "",
        "keywords": [
            "fluorine"
        ],
        "authors": [
            {
                "name": "pei zhou",
                "org": ""
            },
            {
                "name": "jiang fan",
                "org": ""
            },
            {
                "name": "dongfeng dang",
                "org": ""
            },
            {
                "name": "junwei shi",
                "org": ""
            },
            {
                "name": "xiangdong wang",
                "org": ""
            },
            {
                "name": "wenhong peng",
                "org": ""
            },
            {
                "name": "hua tan",
                "org": ""
            },
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2015
    },
    "c56HH95k": {
        "id": "c56HH95k",
        "title": "Influence of the Donor Size in Panchromatic D-\u03c0-A-\u03c0-A Dyes Bearing 5-Phenyl-5 H -dibenzo-[ b,f ]azepine Units for Dye-Sensitized Solar Cells",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "chuncheng yang",
                "org": ""
            },
            {
                "name": "jue chen",
                "org": ""
            },
            {
                "name": "hongrui qi",
                "org": ""
            },
            {
                "name": "jianli hua",
                "org": ""
            },
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "etienne baranoff",
                "org": ""
            },
            {
                "name": "hua tan",
                "org": ""
            },
            {
                "name": "jiang fan",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2016
    },
    "oiiP9p1N": {
        "id": "oiiP9p1N",
        "title": "Increasing thiophene spacers between thieno(3,2- b )thiophene and benzothiadiazole units in backbone to enhance photovoltaic performance for their 2-D polymers",
        "abstract": "",
        "keywords": [
            "polymer solar cells"
        ],
        "authors": [
            {
                "name": "pei zhou",
                "org": ""
            },
            {
                "name": "dongfeng dang",
                "org": ""
            },
            {
                "name": "jiang fan",
                "org": ""
            },
            {
                "name": "wenjing xiong",
                "org": ""
            },
            {
                "name": "chuncheng yang",
                "org": ""
            },
            {
                "name": "hua tan",
                "org": ""
            },
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2015
    },
    "PvE4JbVu": {
        "id": "PvE4JbVu",
        "title": "A novel near-infrared-emitting cyclometalated platinum (II) complex with donor\u2013acceptor\u2013acceptor chromophores",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "junting yu",
                "org": ""
            },
            {
                "name": "keqi he",
                "org": ""
            },
            {
                "name": "yanhu li",
                "org": ""
            },
            {
                "name": "hua tan",
                "org": ""
            },
            {
                "name": "meixiang zhu",
                "org": ""
            },
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "yu liu",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            },
            {
                "name": "hongbin wu",
                "org": ""
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2014
    },
    "iuWbG2ct": {
        "id": "iuWbG2ct",
        "title": "Blue and Green Phosphorescent Liquid\u2010Crystalline Iridium Complexes with High Hole Mobility",
        "abstract": "Blue- and green-emitting cyclometalated liquid-crystalline iridium complexes are realized by using a modular strategy based on strongly mesogenic groups attached to an acetylacetonate ancillary ligand. The cyclometalated ligand dictates the photophysical properties of the materials, which are identical to those of the parent complexes. High hole mobilities, up to 0.004 cm(2) V(-1) s(-1), were achieved after thermal annealing, while amorphous materials show hole mobilities of only approximately 10(-7) -10(-6) cm(2) V(-1) s(-1), similar to simple iridium complexes. The design strategy allows the facile preparation of phosphorescent liquid-crystalline complexes with fine-tuned photophysical properties.",
        "keywords": [
            "phosphorescence",
            "liquid crystals",
            "iridium",
            "hole mobility"
        ],
        "authors": [
            {
                "name": "yafei wang",
                "org": "ministry of education"
            },
            {
                "name": "christopher p cabry",
                "org": "university of york"
            },
            {
                "name": "manjun xiao",
                "org": "ministry of education"
            },
            {
                "name": "louise male",
                "org": "university of birmingham"
            },
            {
                "name": "stephen j cowling",
                "org": "university of york"
            },
            {
                "name": "duncan w bruce",
                "org": "university of york"
            },
            {
                "name": "junwei shi",
                "org": "ministry of education"
            },
            {
                "name": "weiguo zhu",
                "org": "ministry of education"
            },
            {
                "name": "etienne baranoff",
                "org": "university of birmingham"
            }
        ],
        "venue": "Chemistry: A European Journal",
        "year": 2015
    },
    "ZFMYo1RJ": {
        "id": "ZFMYo1RJ",
        "title": "Recent progress in luminescent liquid crystal materials: design, properties and application for linearly polarised emission",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yafei wang",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "junwei shi",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "jianhua chen",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "weiguo zhu",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "etienne baranoff",
                "org": "university of birmingham"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "8jb0811v": {
        "id": "8jb0811v",
        "title": "ChemInform Abstract: Recent Progress in Luminescent Liquid Crystal Materials: Design, Properties and Application for Linearly Polarized Emission",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yafei wang",
                "org": "university of birmingham"
            },
            {
                "name": "junwei shi",
                "org": "university of birmingham"
            },
            {
                "name": "jianhua chen",
                "org": "university of birmingham"
            },
            {
                "name": "weiguo zhu",
                "org": "university of birmingham"
            },
            {
                "name": "etienne baranoff",
                "org": "university of birmingham"
            }
        ],
        "venue": "Cheminform",
        "year": 2015
    },
    "9jIdT2pY": {
        "id": "9jIdT2pY",
        "title": "LASERS, OPTICS, AND OPTOELECTRONICS 2045 Highly efficient electrophosphorescent devices based on conjugated polymers doped with iridium complexes",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weiguo zhu",
                "org": ""
            },
            {
                "name": "yueqi mo",
                "org": ""
            },
            {
                "name": "yuan min",
                "org": ""
            },
            {
                "name": "wei yang",
                "org": ""
            },
            {
                "name": "yong cao",
                "org": ""
            },
            {
                "name": "q k yang",
                "org": ""
            },
            {
                "name": "ch mann",
                "org": ""
            },
            {
                "name": "frank fuchs",
                "org": ""
            },
            {
                "name": "rudolf kiefer",
                "org": ""
            },
            {
                "name": "helen schneider",
                "org": ""
            },
            {
                "name": "joachim wagner",
                "org": ""
            },
            {
                "name": "masayuki fujita",
                "org": ""
            },
            {
                "name": "tomosumi baba",
                "org": ""
            },
            {
                "name": "yoshitaka takano",
                "org": ""
            },
            {
                "name": "kosei kobayashi",
                "org": ""
            },
            {
                "name": "hideaki iwahori",
                "org": ""
            },
            {
                "name": "n kuroyanagi",
                "org": ""
            },
            {
                "name": "katsuhisa kuwahara",
                "org": ""
            },
            {
                "name": "sawa fuke",
                "org": ""
            },
            {
                "name": "sho shirakata",
                "org": ""
            },
            {
                "name": "hideki hirayama",
                "org": ""
            },
            {
                "name": "makoto ainoya",
                "org": ""
            },
            {
                "name": "atsuhiro kinoshita",
                "org": ""
            },
            {
                "name": "akira hirata",
                "org": ""
            },
            {
                "name": "yoshinobu aoyagi",
                "org": ""
            },
            {
                "name": "rian zhao",
                "org": ""
            },
            {
                "name": "michael j cich",
                "org": ""
            },
            {
                "name": "p specht",
                "org": ""
            },
            {
                "name": "e r weber",
                "org": ""
            },
            {
                "name": "w z shen",
                "org": ""
            },
            {
                "name": "l f jiang",
                "org": ""
            },
            {
                "name": "haifang yang",
                "org": ""
            },
            {
                "name": "f y meng",
                "org": ""
            },
            {
                "name": "hirotsugu ogawa",
                "org": ""
            },
            {
                "name": "qixin guo",
                "org": ""
            },
            {
                "name": "masahiro ohtani",
                "org": ""
            },
            {
                "name": "teruo fukumura",
                "org": ""
            },
            {
                "name": "masashi kawasaki",
                "org": ""
            },
            {
                "name": "kazuhiko omote",
                "org": ""
            },
            {
                "name": "toru kikuchi",
                "org": ""
            },
            {
                "name": "j harada",
                "org": ""
            },
            {
                "name": "hiedeomi koinuma",
                "org": ""
            },
            {
                "name": "jan schroers",
                "org": ""
            },
            {
                "name": "william l johnson",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2002
    },
    "wnq1uGLQ": {
        "id": "wnq1uGLQ",
        "title": "Synthesis and optoelectric properties of fluorene-alt-benzene organic phosphorescent polymers containing pendent cyclometalated iridium complex",
        "abstract": "A series of novel phosphorescent polymers consisting of fluorene-alt-benzene as building block in the main chain and cyclometalated iridium complex as the pendent in the branch were synthesized by coupling polymerization. All of these resulting polymers presented a good thermal stability, an intense absorption in the region of 300\u2013400 nm and a bright blue emission in solution. On contrary, the polymers exhibited dual emission spectra originated from the backbones and iridium complex unit in the neat film. Polymer organic light-emitting diodes employing these polymers as the single emissive layer with the configuration of ITO/PEDOT : PSS (50 nm)/phosphorescent polymer (45 nm)/LiF (0.5 nm)/Al (150 nm) were fabricated. The devices revealed a maximum brightness 43 cd/m2 with a low molar concentration of iridium complex (1%).",
        "keywords": [
            "Polymer Science Series",
            " Iridium",
            " Iridium Complex",
            " Tetrabutyl Ammo Nium Hexafluorophosphate",
            " Thin Film State"
        ],
        "authors": [
            {
                "name": "jiyong deng",
                "org": "xiangtan university"
            },
            {
                "name": "liu yu",
                "org": "xiangtan university"
            },
            {
                "name": "hua tan",
                "org": "xiangtan university"
            },
            {
                "name": "xianwei huang",
                "org": "hunan institute of engineering"
            },
            {
                "name": "weiguo zhu",
                "org": "xiangtan university"
            }
        ],
        "venue": "Polymer Science Series B",
        "year": 2014
    },
    "9oz9Pmvs": {
        "id": "9oz9Pmvs",
        "title": "Red Electroluminescence and Photoluminescence from Novel Binuclear Europium Complex with Squaric Acid Ligand",
        "abstract": "A novel binuclear europium \u03b2-diketone complex with squaric acid ligand was synthesized for the first time. Its structure was elucidated by IR, UV, and Elemental Analysis. Red light emitting diode (LED) was fabricated by using the novel europium complex as an emitting layer, tris(8-quinolinolate) aluminum (III) (Alq3) as an electron-transporting layer, N, N\u2032-diphenyl-N, N\u2032-(3-methylphenyl)-1,1\u2032-biphenyl-4,4\u2032-diamine (TPD) as a hole-transporting layer. A cell structure of indium-tin-oxide/TPD/Eu-complex/Alq3/Mg: Ag was employed. Red electroluminescence was observed at room temperature with dc bias voltage of 2 V in this cell. Red emission peaks at about 613 nm with maximum luminance of over 106 cd/m2. Compared with the EL luminance from those europium complexes reported before, one from the Eu-complex is best in the same cells.",
        "keywords": [
            "Electroluminescence (EL)",
            "Europium chelate",
            "Photoluminescence (PL)",
            "Squaric acid"
        ],
        "authors": [
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "XiaoQiang Wei",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Zhiyun Lu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Bo Liang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "MingGui Xie",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Deqiang Zhang",
                "org": "Tsinghua University(Tsinghua University,Tsinghua Univ,Tsinghua Univ.),Beijing,China"
            },
            {
                "name": "Yong Qiu",
                "org": "Tsinghua University(Tsinghua University,Tsinghua Univ,Tsinghua Univ.),Beijing,China"
            }
        ],
        "venue": "Chinese Chemical Letters",
        "year": 2001
    },
    "e7y6eDQj": {
        "id": "e7y6eDQj",
        "title": "Synthesis and photoluminescence of new europium complex Eu(DBM)3(DPPZ) with dipyridophenazine ligand",
        "abstract": "Dipyrido [3, 2-a:2\u2032,3\u2032-c] phenazine moiety has been introduced as neutral ligand in europium complex. Therefore, a new europium complex with saturated emission, strong fluorescent intensity and good solubility was designed and synthesized for the first time. Its photoluminescence and UV properties were examined. The experimental results showed that this new Eu-complex could be used as red electroluminescent materials.",
        "keywords": [
            "Dipyridophenazine",
            "Europium complexes",
            "Photoluminescence (PL) property",
            "Synthesis"
        ],
        "authors": [
            {
                "name": "Bo Liang",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Meixiang Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            }
        ],
        "venue": "Chinese Chemical Letters",
        "year": 2003
    },
    "YbMqj5tT": {
        "id": "YbMqj5tT",
        "title": "Electroluminescent devices based on binuclear europium chelate with square acid as bridge ligand",
        "abstract": "A novel europium chelate, Eu 2(DBM) 4(Sq)Phen 2, which has a bridge ligand of squaric acid, was synthesized and used as organic electroluminescent materials. Five light-emitting diodes using TPD as hole-transporting material, Eu 2(DBM) 4(Sq)Phen 2 as emitting material, and AlQ as electron-transporting material were fabricated. The results indicate that this europium chelate possesses both hole-transporting and electron-transporting abilities. When the structure of device is ITO/TPD, 50 nm/Eu 2 (DBM) 4(Sq)Phen 2, 20 nm/AIQ, 50 nm/LiF, 1 nm/Al, 200 nm, the maximum luminance of 91 cd/m 2 at 16 V was achieved.",
        "keywords": [
            "Electroluminescence",
            "Europium chelate",
            "Photoluminescence",
            "Square acid"
        ],
        "authors": [
            {
                "name": "XiaoQiang Wei",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "XiangTan University(Xiangtan University),Xiangtan,China"
            },
            {
                "name": "Ai L. Yang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "LongZhang Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "MingGui Xie",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Gang Yang",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            },
            {
                "name": "Zulun Lin",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            },
            {
                "name": "Jianbo Cheng",
                "org": "University of Electronic Science and Technology of China(University of Electronic Science and Technology of China),Chengdu,China"
            }
        ],
        "venue": "Acta Chimica Sinica",
        "year": 2003
    },
    "J9BhyRFW": {
        "id": "J9BhyRFW",
        "title": "Novel red to near-infrared phosphorescent complexes based on phenanthrene derivates as ligands: synthesis, characterization and photoluminescence and electroluminescence properties",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weiguo zhu",
                "org": ""
            },
            {
                "name": "xianping deng",
                "org": ""
            },
            {
                "name": "s u yiwei",
                "org": ""
            },
            {
                "name": "kaijun luo",
                "org": ""
            },
            {
                "name": "yanfang chen",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "sNEIDZOg": {
        "id": "sNEIDZOg",
        "title": "Iridium(III) complexes with 5-substitute-8-quinolinolates and 2-phenylpyridine as ligands: Synthesis, characterization and photoluminescent as well as electroluminescent properties",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yanfang chen",
                "org": ""
            },
            {
                "name": "kaijun luo",
                "org": ""
            },
            {
                "name": "s u yiwei",
                "org": ""
            },
            {
                "name": "xianping deng",
                "org": ""
            },
            {
                "name": "l i maowei",
                "org": ""
            },
            {
                "name": "baijing zhao",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            },
            {
                "name": "juan jia",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "vbLDYExW": {
        "id": "vbLDYExW",
        "title": "TD-DFT Study on Electronic Spectrum Properties of Zinc Complex with 8-Thiolquinoline Anion and Its Derivatives",
        "abstract": "Luminescent organic/organometallic compounds have attracted much attention recently because of their applications to electroluminescent display. The most well-known example of such chelate com- pounds is Alq3, q=deprotonated 8-hydroxyquinoline, a green emitter and an electron transporter in organic EL devices. The structures of zinc complex with 8-thiolquinoline anion [Zn(tq)2] and its derivatives were optimized in the ground state using ab initio HF and B3LYP methods, and absorption spectra based on the above structures were obtained by the time-dependent density functional theory (TD-DFT) by the B3LYP method with the 6-31+G(d) basis set. At the same time, the molecular structure of the first singlet excited state for Zn(tq)2 and its derivatives was optimized by CIS/6-31G(d), and the EL peak could be obtained by the emission spectrum with TD-B3LYP/6-31G(d) method. The calculated results indicated that the lumines- cence originates from the electronic transition from the thiophenol ring to the pyridine ring. The calculated results of absorption spectrum and emission spectrum for zinc complex with 8-thiolquinoline anion and its derivatives have good agreement with the experimental data. All compounds are excellent electron- transporting materials, luminescence wave bands of which can be tuned by different metals and substituent on the ligand of 8-thiolquinoline anion.",
        "keywords": [
            "absorption spectrum",
            "time-dependent density functional theory",
            "emission spectrum",
            "zinc complex with 8-thiolquinoline anion",
            "zinc",
            "spectrum"
        ],
        "authors": [
            {
                "name": "xiaobing li",
                "org": ""
            },
            {
                "name": "xueye wang",
                "org": ""
            },
            {
                "name": "xinliang yu",
                "org": ""
            },
            {
                "name": "jinwei gao",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Acta Chimica Sinica",
        "year": 2006
    },
    "YbQNhsyA": {
        "id": "YbQNhsyA",
        "title": "Dinuclear cyclometalated iridium (III) complex containing functionalized triphenylamine core: synthesis, photophysics and application in the single-emissive-layer WOLEDs",
        "abstract": "Abstract   To obtain highly efficient white-emitting devices, a novel functionalized dinuclear iridium (III) complex of C 8 TPA(FIrpic) 2  was successfully synthesized and characterized. In this phosphor, FIrpic is a blue-emitting phosphorescent chromophore of iridium(III) bis[(4,6-difluorophenyl)pyridinato-N,C2\u2032] picolate and C 8 TPA is a blue-emitting fluorescent chromophore of triphenylamine as bridging donor. Its optophysical and electro-phosphorescent properties were primarily investigated. White emission with an increasing current efficiency of 1.31\u00a0cd/A at 15.3\u00a0mA/cm 2  and brightness of 1770\u00a0cd/m 2  at 656.3\u00a0mA/cm 2  was obtained in its single-emissive-layer OLEDs with a configuration of ITO/PEDOT:PSS/C 8 TPA(FIrpic) 2  (10\u00a0wt\u00a0%):TCTA/TPBi/LiF/Al. The results indicate that an introduction of triphenylamine group into dinuclear iridium (III) complexes as bridged donor can improve the performance of its iridium (III) complexes-doped OLEDs.",
        "keywords": "",
        "authors": [
            {
                "name": "Keqi He",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Ning Su",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Yu Junting",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Yu Liu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Wenjing Xiong",
                "org": "School of Materials Science and Engineering, Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou 213164, China"
            },
            {
                "name": "Zhaoran Hao",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Dongge Ma",
                "org": "State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "School of Materials Science and Engineering, Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou 213164, China"
            }
        ],
        "venue": "Tetrahedron",
        "year": 2016
    },
    "0pDstotT": {
        "id": "0pDstotT",
        "title": "Tuning color-correlated temperature and color rendering index of phosphorescent white polymer light-emitting diodes: Towards healthy solid-state lighting",
        "abstract": "Abstract   We report on efficient solution-processed phosphorescent white polymer light-emitting diodes (WPLEDs) with tunable color-correlated temperature (CCT) and color rendering index (CRI), through rationally controlling the composition of the emission layer (EML) based on a near-infrared (NIR)-emitting dinuclear cyclometalated platinum (II) complex bridged with N\u02c6S anionic ligand, named (niq) 2 Pt 2 (\u03bc-C 8 PhOXT) 2  (Pt-1, in which PhOXT is 5-(phenyl-1,3,4-oxadiazole)-2-thiol, niq is 1-naphthylisoquinolinato), a sky-blue emitter iridium (III) bis[(4,6-di-fluorophenyl)-pyridinato-N,C2] (picolinate) (FIrpic), and a yellow emitter bis[2-(thieno[3,2- c ]pyridin-4-yl)phenyl]iridium(III)(acetylacetonato) (PO-01). One of the best three-color WPLEDs shows a CCT of 3246\u00a0K as well as an excellent high CRI of 87, which are greatly beneficial in reducing deep-blue light damage and simultaneously meet the requirement for good color reproduction. Meanwhile, the relevant WPLED also achieves a maximum current efficiency of 12.1\u00a0cd/A, corresponding to an external quantum efficiency of 10.6%. This work presents an effective approach through rational combination of sky-blue, yellow, and NIR emitters towards high-performance solution-processable WPLEDs with a physiologically-friendly CCT and a high CRI.",
        "keywords": "",
        "authors": [
            {
                "name": "Fanyuan Meng",
                "org": "State Key Laboratory of Luminescent Materials and Devices, Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology, Guangzhou 510640, China"
            },
            {
                "name": "Dongcheng Chen",
                "org": "State Key Laboratory of Luminescent Materials and Devices, Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology, Guangzhou 510640, China"
            },
            {
                "name": "Wenjing Xiong",
                "org": "Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Hua Tan",
                "org": "Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Yafei Wang",
                "org": "Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Shi-Jian Su",
                "org": "State Key Laboratory of Luminescent Materials and Devices, Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology, Guangzhou 510640, China"
            }
        ],
        "venue": "Organic Electronics",
        "year": 2016
    },
    "wz8fJ1al": {
        "id": "wz8fJ1al",
        "title": "Structure-performance correlation of indacenodithiophene-based narrow band-gap polymers with pendant diketopyrrolopyrrole units",
        "abstract": "Abstract   Two novel indacenodithiophene (IDT) based narrow band-gap polymers (PIDT-BDTDPP and PIDT-TDPP) with pendant diketopyrrolopyrrole (DPP) units onto different main chains were designed and synthesized. The structures and properties of these main chain donor-side chain acceptor D-A copolymers were fully characterized. The PIDT-TDPP with pendant DPP units onto thiophene (T) units exhibited better light-harvesting properties and charge transport properties. While the PIDT-BDTDPP with pendant DPP units onto benzo[1,2- b :4,5- b \u2032]dithiophene (BDT) units displayed lower the highest occupied molecular orbital energy levels (HOMO). By blending these polymers as light-harvesting electron donors with (6,6)-phenyl-C 61 -butyric acid methyl ester (PC 61 BM) electron acceptors in bulk heterojunction solar cells, it was found that the PIDT-TDPP-based PSCs shown better photovoltaic performance and a power conversion efficiency (PCE) of 3.62%, an open-circuit voltage ( V  OC ) of 0.79\u00a0V, a short-circuit current ( J  SC ) of 9.27\u00a0mA\u00a0cm \u22122  and a fill factor ( FF ) of 49.7% were achieved. The PCE level is 1.88 times higher than that in the PIDT-BDTDPP-based PSCs.",
        "keywords": "",
        "authors": [
            {
                "name": "Junting Yu",
                "org": "Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, PR China"
            },
            {
                "name": "Jiamin Cao",
                "org": "Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, PR China"
            },
            {
                "name": "Hua Tan",
                "org": "Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Wenhong Peng",
                "org": "Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Yafei Wang",
                "org": "School of Materials Science and Engineering, Changzhou University, Changzhou 213164, PR China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, PR China"
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2017
    },
    "aJ78fU3y": {
        "id": "aJ78fU3y",
        "title": "Combined optimization of emission layer morphology and hole-transport layer for enhanced performance of perovskite light-emitting diodes",
        "abstract": "Electroluminescence performance of perovskite light-emitting diodes (PeLEDs) is extremely dependent on the morphology of the perovskite films, which is influenced by the processing method. Herein, we report an effective approach for the preparation of a high-quality perovskite film with perfect performance for PeLEDs via a solution process at room temperature. On the one hand, CH3NH3PbBr3 (MAPbBr3) precursor solution was blended with a traditional polymeric host PVK [poly(vinylcarbazole)] to obtain smooth and uniform perovskite films. On the other hand, the perovskite films could be further improved through crystal modification to obtain a more uniform morphology and smaller grain sizes. Our research also demonstrated the feasibility of preparing high-performance solution-processed PeLEDs by blending small molecule hole-transport materials (HTMs) with polymer HTMs (widely used in OLEDs as hole-transport layers (HTLs)). Efficient green PeLEDs with a current efficiency (CE) of 6.7 cd A\u22121, external quantum efficiency (EQE) of 1.88%, and low turn-on voltage of 2.9 V were achieved; this indicates that the effective solution process used to improve the morphology of the perovskite films as well as carrier injection has great potential for the development of high-performance PeLEDs.",
        "keywords": "",
        "authors": [
            {
                "name": "Fanyuan Meng",
                "org": "State Key Laboratory of Luminescent Materials and Devices and Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology,Guangzhou 510640,China"
            },
            {
                "name": "Fanyuan Meng",
                "org": "State Key Laboratory of Luminescent Materials and Devices and Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology,Guangzhou 510640,China"
            },
            {
                "name": "Chongyang Zhang",
                "org": "State Key Laboratory of Luminescent Materials and Devices and Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology,Guangzhou 510640,China"
            },
            {
                "name": "Dongcheng Chen",
                "org": "State Key Laboratory of Luminescent Materials and Devices and Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology,Guangzhou 510640,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, College of Chemistry, Xiangtan University,Xiangtan 411105,China"
            },
            {
                "name": "Hin-Lap Yip",
                "org": ""
            },
            {
                "name": "Shi-Jian Su",
                "org": "State Key Laboratory of Luminescent Materials and Devices and Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology,Guangzhou 510640,China"
            }
        ],
        "venue": "Journal of Materials Chemistry C",
        "year": 2017
    },
    "ysexTfaE": {
        "id": "ysexTfaE",
        "title": "Enhancing the photovoltaic properties of low bandgap terpolymers based on benzodithiophene and phenanthrophenazine by introducing different second acceptor units",
        "abstract": "Two novel donor\u2013acceptor (D\u2013A) type random conjugated terpolymers PBDTT-PPzIID and PBDTT-PPzDPP were synthesized by copolymerizing electron-rich alkylthienyl benzodithiophene (BDTT) and two different electron-deficient units, in which phenanthrophenazine (PPz) was the first acceptor unit, and isoindigo (IID) or diketopyrrolopyrrole (DPP) with a strong electron-withdrawing ability was the second acceptor unit, respectively. Compared to their parent polymer PTTPPz-BDTT, a broadening of the band in the long wavelength region from 500 to 850 nm and a significant decrease in HOMO levels were observed for the random terpolymers. Ca and PFN-Br were used as interfacial layers to optimize the devices, respectively. Pleasingly, after replacing Ca/Al with PFN-Br/Al as the cathode, the performance of both polymer devices improved greatly. A maximum power conversion efficiency (PCE) of 5.91% was obtained with a Voc of 0.73 V, a Jsc of 11.75 mA cm\u22122 and a FF of 68.8% in the PBDTT-PPzDPP/PC71BM-based device, while the PBDTT-PPzIID/PC71BM-based device achieved a PCE of 4.21%. To the best of our knowledge, this is one of the highest recorded FF values among PSCs based on previously reported phenazine copolymers.",
        "keywords": "",
        "authors": [
            {
                "name": "Qunping Fan",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Xiaopeng Xu",
                "org": "Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University,Chengdu 610064,China"
            },
            {
                "name": "Yu Liu",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Wenyan Su",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Xunming He",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Youming Zhang",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Qiang Peng",
                "org": "Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University,Chengdu 610064,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            }
        ],
        "venue": "Polymer Chemistry",
        "year": 2016
    },
    "BB9my8wF": {
        "id": "BB9my8wF",
        "title": "Tetradentate Pt(II) 3,6-substitued salophen complexes: Synthesis and tuning emission from deep-red to near infrared by appending donor-acceptor framework",
        "abstract": "Abstract   Two novel tetradentate platinum (II) 3,6-substituted salophen complexes of Pt-2 and Pt-3 were synthesized and characterized, in which the substituted group is a donor (D) unit of 4,4\u2032-di( tert -butyl)triphenylamine (Bu t TPA) for Pt-2 and a donor-acceptor (D-A) framework of Bu t TPA and benzothiadiazole (BT) for Pt-3. Their thermal, optophysical, electrochemical and electroluminescent properties were primarily investigated. It is found that the emission for this type of tetradentate platinum (II) complexes is tuned from deep red to near infrared by appending D-A framework under photo-excitation. As a result, Pt-3 presented a significant near infrared electroluminescence peaked at 703\u00a0nm in its doped polymer light-emitting devices (PLEDs). The maximum external quantum efficiency of 0.88% is observed in the Pt-3 doped PLEDs using a blend of poly(vinylcarbazole) and 1,3-bis(5-(4-( tert -butyl)phenyl)-1,3,4-oxadiazol-2-yl) benzene as the host matrix. Our work indicates that appending D-A framework into tetradentate Pt(II) salophen complex is a useful strategy to get high-performance near infrared emission for this type of tetradentate Pt (II) complexes.",
        "keywords": "",
        "authors": [
            {
                "name": "Youming Zhang",
                "org": "Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, Department of Materials Chemistry, School of Materials Science and Engineering, Changzhou University, Changzhou 213164, China"
            },
            {
                "name": "Zheng Yin",
                "org": "Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, Department of Materials Chemistry, School of Materials Science and Engineering, Changzhou University, Changzhou 213164, China"
            },
            {
                "name": "Fanyuan Meng",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Fanyuan Meng",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Junting Yu",
                "org": "School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China"
            },
            {
                "name": "Caifa You",
                "org": "Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, Department of Materials Chemistry, School of Materials Science and Engineering, Changzhou University, Changzhou 213164, China"
            },
            {
                "name": "Shengyi Yang",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, Department of Materials Chemistry, School of Materials Science and Engineering, Changzhou University, Changzhou 213164, China"
            },
            {
                "name": "Shi-Jian Su",
                "org": "Institute of Polymer Optoelectronic Materials and Devices, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China"
            }
        ],
        "venue": "Organic Electronics",
        "year": 2017
    },
    "oE99euJs": {
        "id": "oE99euJs",
        "title": "An overview of phosphorescent metallomesogens based on platinum and iridium",
        "abstract": "Metal atoms with excellent magnetic, electrical and optical properties that are integrated into liquid crystal molecules \u2013 metallomesogens \u2013 have attracted much attention from chemists, physicists and engineers and many materials based on e.g. Ag, Pt, Pd, Ir, Ni, Cu and lanthanide ions have been reported. Though several reviews and books have been published on metallomesogens, few refer to their photophysical properties. Additionally, metallomesogens with good emission properties in solution or in neat film are still scarce. Owing to the 100% theoretical internal quantum efficiency, phosphorescent liquid-crystalline materials were developed recently. Here, a brief overview of recent research on such materials based on platinum and iridium complexes including their molecular design and structure\u2013property relationships is reported. It is hoped that this review will stimulate further development of luminescent metallomesogens.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiugang Wu",
                "org": ""
            },
            {
                "name": "Mengbing Zhu",
                "org": ""
            },
            {
                "name": "Duncan W. Bruce",
                "org": "Department of Chemistry, University of York,Heslington,UK"
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            },
            {
                "name": "Yafei Wang",
                "org": ""
            }
        ],
        "venue": "Journal of Materials Chemistry C",
        "year": 2018
    },
    "hkr4qg1S": {
        "id": "hkr4qg1S",
        "title": "Near-infrared emitting pyrazole-bridged binuclear platinum complexes: Synthesis, photophysical and electroluminescent properties in PLEDs",
        "abstract": "Abstract   Two novel near-infrared emitting binuclear platinum (II) complexes were successfully designed and synthesized with the bridged ancillary ligand of 3,5-dimethyl pyrazol, in which 2-(pyren-1-yl) pyridine and its derivative of 2-(7-( tert -butyl)pyren-1-yl)pyridine were used as cyclometalated ligands, respectively. Their photophysical, thermal, electrochemical, as well as electro-luminescent properties were investigated. The intrinsic near-infrared electro-luminescent spectra peaked at 692\u00a0nm with a shoulder at 753\u00a0nm was observed in the single-emissive-layer polymer light-emitting diodes using both binuclear platinum (II) complexes as the dopant. The  tert -butyl group attached in pyrenyl ring was found to play an important role in improving electroluminescent properties. Better electroluminescent properties were obtained for the platinum complex with 2-(7-( tert -butyl)pyren-1-yl)pyridine in the devices with a maximum external quantum efficiency of 0.15% and a radiant intensity of 19.10\u00a0\u03bcW\u00a0cm \u22122 . To our best knowledge, this is a first reported example on the near-infrared electroluminescence of binuclear platinum complex containing pyrazoline auxiliary ligand.",
        "keywords": "",
        "authors": [
            {
                "name": "Ning Su",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, People's Republic of China"
            },
            {
                "name": "Fanyuan Meng",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, People's Republic of China"
            },
            {
                "name": "Fanyuan Meng",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, People's Republic of China"
            },
            {
                "name": "Jianhua Chen",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, People's Republic of China"
            },
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, People's Republic of China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, People's Republic of China"
            },
            {
                "name": "Shi-Jian Su",
                "org": "Institute of Polymer Optoelectronic Materials and Devices, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, People's Republic of China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, People's Republic of China"
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2016
    },
    "I16rcSKX": {
        "id": "I16rcSKX",
        "title": "Dinuclear cyclometalated platinum(ii) complexes containing a deep blue fluorescence chromophore: synthesis, photophysics and application in single dopant white PLEDs.",
        "abstract": "To control excimer/aggregation emission and achieve a single active emitter of aggregation for controllable white polymer light-emitting devices (PLEDs), two star-shaped dinuclear platinum(ii) complexes of C6DBCzC6-DFPt(pic) and DPy(TPA)-C6DBCzC6-DFPt(pic) were synthesized and characterized, in which DBCz is a 3,6-diphenyl-carbazole bridged core, C6 is an unconjugated dioxyhexyloxy linkage, DPy(TPA) is (4,4'-di(pyren-1-yl)triphenylamine), a deep blue-emitting fluorescent chromophore, and DPtF(pic) is a dinuclear platinum(ii) [(4,6-difluorophenyl)-pyridinato-N,C(2')](picolinate) blue-emitting phosphorescent chromophore. Compared to its parent complex C6DBCzC6-DFPt(pic), DPy(TPA)-C6DBCzC6-DFPt(pic) showed a lower lying highest occupied molecular energy level (HOMO) and lowest unoccupied molecular energy level (LUMO). Under a current of 2.5 mA, near-white emission was obtained in the DPy(TPA)-C6DBCzC6-DFPt(pic)-doped devices at dopant concentrations from 4 wt% to 10 wt%. However, green-yellow emission was obtained in the C6DBCzC6-DFPt(pic)-doped devices with the same device configuration using a blend of polyvinylcarbazole (PVK) and 2-(4-biphenyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole (PBD) as a host matrix, respectively. This indicates that incorporating a deep blue fluorescent chromophore into a green-yellow emitting dinuclear platinum(ii) complex is an available way to control aggregation/excimer emissions and get white-emitting PLEDs with a single dopant. ",
        "keywords": "",
        "authors": [
            {
                "name": "Youming Zhang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, P. R. China. liuyu03b@126.com zhuwg18@126.com."
            },
            {
                "name": "Haigang Jiang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University,Xiangtan 411105,P. R. China"
            },
            {
                "name": "Yu Liu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University,Xiangtan 411105,P. R. China"
            },
            {
                "name": "Kaifeng Zhou",
                "org": "State Key Laboratory of Luminescent Materials and Devices, South China University of Technology,Guangzhou 510640,P. R. China"
            },
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University,Xiangtan 411105,P. R. China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University,Xiangtan 411105,P. R. China"
            },
            {
                "name": "Shijian Su",
                "org": "State Key Laboratory of Luminescent Materials and Devices, South China University of Technology,Guangzhou 510640,P. R. China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University,Xiangtan 411105,P. R. China"
            }
        ],
        "venue": "Dalton transactions (Cambridge, England : 2003)",
        "year": 2016
    },
    "Lq9OYpSI": {
        "id": "Lq9OYpSI",
        "title": "Influence of integrated alkyl-chain length on the mesogenic and photophysical properties of platinum-based metallomesogens and their application for polarized white OLEDs",
        "abstract": "Abstract   In this context, a series of platinum complexes containing a triphenylene unit, namely  Pt5   Pt8 , was prepared and characterized. Platinum complex  Pt6  shows a clearly column liquid crystalline property, confirmed by differential scanning calorimetry, polarized optical microscopy and X-ray diffraction. These platinum complexes only display monomolecular emission both in solution and in neat film, an effect attributed to the presence of carbazole as a bulky group disfavoring aggregation of the complexes. Hole mobilities in the range of 10 \u22125 \u201310 \u22126 \u00a0cm 2 \u00a0V \u22121  s \u22121  were obtained for the annealed platinum complexes films. It was found that the method to align the emissive layer has a crucial role on the performance of the devices. The first example of polarized phosphorescent white organic light-emitting diode (OLED) with polarized ratio of 1.4 was achieved in  Pt6 -based device. This research opens up a new aspect of phosphorescent metallomesogens application for polarized white light emission.",
        "keywords": "",
        "authors": [
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan, 411105, China"
            },
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan, 411105, China"
            },
            {
                "name": "Jiang Fan",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan, 411105, China"
            },
            {
                "name": "Junwei Shi",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan, 411105, China"
            },
            {
                "name": "Hongrui Qi",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan, 411105, China"
            },
            {
                "name": "Etienne Baranoff",
                "org": "School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK"
            },
            {
                "name": "Guohua Xie",
                "org": "Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Hubei Key Lab on Organic and Polymeric Optoelectronic Materials, Department of Chemistry, Wuhan University, Wuhan, 430072, China"
            },
            {
                "name": "Qingguo Li",
                "org": "College of Chinese Medicines, Guangzhou University of Chinese Medicine, Guangzhou, 510640, China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan, 411105, China"
            },
            {
                "name": "Yu Liu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan, 411105, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan, 411105, China"
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2016
    },
    "g1dRh4TT": {
        "id": "g1dRh4TT",
        "title": "Synthesis and optoelectronic properties of dinuclear cyclometalated platinum (II) complexes containing naphthalene-functionalized carbazole groups in the single-emissive-layer WPLEDs",
        "abstract": "Abstract   To tune excimer/aggregation emission and obtain single emissive dopants for white polymer light-emitting diodes (WPLEDs), two novel star-shaped dinuclear cyclometalated platinum (II) complexes, namely DPtF(pic)C 6 TPhC 6 D(dHCz) and DPtF(pic)C 6 TPhC 6 D(dNaCz), have been synthesized and characterized, where DPtF(pic) is dinuclear platinum (II) [(4,6-difluorophenyl)-pyridinato-N,C 2 \u2032](picolinate) blue-emitting phosphorescent chromophore, D(dHCz) and D(dNaCz) are blue emitting fluorescent chromophores containing carbazole or naphthalene functionalized carbazole group, respectively, TPh is  p -terphenyl used as central bridging core, finally, each parts of molecular skeleton are wired through nonconjugated hexyloxy ether linkage (C 6 ). Their thermal, electrochemical and optophysical properties were primarily investigated. The device fabricated with these complexes doped into a host polyvinylcarbazole (PVK) blend with 30\u00a0wt % of an electron transport material 1,3-bis-(5-(4-( tert -butyl)phenyl)-1,3,4-oxadiazol-2-yl)benzene (OXD-7) showed near-white emission at lower dopant concentration. At 1\u00a0wt % dopant concentration, DPtF(pic)C 6 TPhC 6 D(dHCz) exhibited near-white emission with a luminous efficiency ( LE ) of 1.12\u00a0cd/A and a maximum external quantum efficiency ( EQE ) of 0.57% (Commission Internationale de Iu0027Eclairage(CIE) chromaticity coordinates: (0.27, 0.40)) at 2.72\u00a0mA/cm 2 . At the same dopant concentration, DPtF(pic)C 6 TPhC 6 D(dNaCz) showed much tunable near-white emission with a  LE  of 0.99\u00a0cd/A and a  EQE  of 0.51% (CIE: 0.30, 0.41) at 0.87\u00a0mA/cm 2 .",
        "keywords": "",
        "authors": [
            {
                "name": "Zhaoran Hao",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Yu Liu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Ying Huang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Fanyuan Meng",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Fanyuan Meng",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Shi-Jian Su",
                "org": "State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            }
        ],
        "venue": "Journal of Organometallic Chemistry",
        "year": 2017
    },
    "xYpUvY19": {
        "id": "xYpUvY19",
        "title": "Spirotriphenylamine based star-shaped D-A molecules meeting AIE chromophore for both efficient solution-processed doped and nondoped blue organic light-emitting diodes",
        "abstract": "Abstract   To explore the structure-property of donor-acceptor (D-A) type blue emitter, in this contribution, four star-shaped compounds of  p -TPA,  m -TPA,  p -TPA-TPE and  m -TPA-TPE using spirotriphenylamine as the donor unit and triazine as the acceptor core were designed and prepared. The tetraphenylethene (TPE) unit was introduced into the D-A molecules to enhance the emission efficiency in solid state. The photophysical properties of all compounds were comparatively studied through experimental and theoretical methods. All these D-A compounds displayed blue emission (443\u2013487\u00a0nm) both in solution and neat film. Compared to  p -TPA and  m -TPA,  p -TPA-TPE and  m -TPA-TPE possessed clear aggregated-induced emission (AIE) property and higher emission efficiency in the solid state. Both the doped and non-doped organic light-emitting diodes (OLEDs) based on  m -TPA and  m -TPA-TPE were fabricated by solution-processable approach. The  m -TPA-TPE based non-doped device showed a satisfying performance with a high current efficiency of 4.2\u00a0cd/A and an external quantum efficiency of 1.8% in the bluish-green region. This research demonstrates that integrating AIE unit into D-A molecule is an effective strategy for design high efficient blue emitter in non-doped OLEDs.",
        "keywords": "",
        "authors": [
            {
                "name": "Yafei Wang",
                "org": "Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, School of Materials Science and Engineering, Jiangsu Collaboration Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou 213164, PR China"
            },
            {
                "name": "Wanhui Liu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Zuoming Qu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Yu Liu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Guohua Xie",
                "org": "Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Hubei Key Lab on Organic and Polymeric Optoelectronic Materials, Department of Chemistry, Wuhan University, Wuhan 430072, PR China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, School of Materials Science and Engineering, Jiangsu Collaboration Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou 213164, PR China"
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2017
    },
    "dcMN853S": {
        "id": "dcMN853S",
        "title": "Broadband spectra with fluorescence and phosphorescence dual emission from bichromophoric platinum metallomesogens containing a 6,12-dihydro-indeno[1,2-b]fluorene linkage",
        "abstract": "Two binuclear platinum metallomesogens possessing a 6,12-dihydro-indeno[1,2-b]fluorene bridge, FJ-1 and FJ-2, have been synthesised and characterised by 1H and 13C NMR, TOF-MS and elemental analysis. Their thermal properties were studied by polarised optical microscopy and differential scanning calorimetry. Upon photoexcitation in solution, both complexes exhibited dual fluorescence (1\u03c0\u2013\u03c0*)/phosphorescence (3\u03c0\u2013\u03c0*) emission covering most of the visible spectrum (from about 460 nm to 750 nm). This uncommon behaviour has been further investigated by time-resolved optical spectroscopy, including nanosecond time-resolved transient absorption spectroscopy, and further insights were obtained by means of density functional theory (DFT) and time-dependent DFT (TD-DFT). An organic light-emitting diode (OLED) using FJ-1 was prepared. Importantly the two emission bands are retained in electroluminescence. This result suggests that controlling spin\u2013orbit coupling to obtain dual emission can provide an effective way of achieving broadband emission based on a single molecule.",
        "keywords": "",
        "authors": [
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University,Xiangtan 411105,China"
            },
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University,Xiangtan 411105,China"
            },
            {
                "name": "Jiang Fan",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University,Xiangtan 411105,China"
            },
            {
                "name": "Tianyi Li",
                "org": "School of Chemistry and Chemical Engineering, Nanjing University,Nanjing 210093,PR China"
            },
            {
                "name": "Qiong Wang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University,Xiangtan 411105,China"
            },
            {
                "name": "Junwei Shi",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University,Xiangtan 411105,China"
            },
            {
                "name": "Zuoming Qu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University,Xiangtan 411105,China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University,Xiangtan 411105,China"
            },
            {
                "name": "Yu Liu",
                "org": ""
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            }
        ],
        "venue": "RSC Advances",
        "year": 2016
    },
    "clUzPWah": {
        "id": "clUzPWah",
        "title": "Achieving NIR emission for tetradentate platinum (II) salophen complexes by attaching dual donor-accepter frameworks in the heads of salophen",
        "abstract": "Abstract   Two novel tetradentate platinum (II) salophen complexes A and B, respectively substituted by dual donor-accepter frameworks of phenazine-triphenylamine in the heads and waists of salophen, were synthesized and characterized. By changing the substituted positions of dual phenazine-triphenylamine units, different optophysical, electrochemical and electroluminescent properties were remarkably observed for the both platinum (II) salophen complexes. Using a blend of poly(vinyl-carbazole) (PVK) and 1,3-bis(5-(4-( tert -butyl) phenyl)-1,3,4-oxadiazol-2-yl)benzene (OXD-7) as host matrix, the platinum (II) salophen complexes A and B exhibited a deep red emission at 653\u00a0nm and a near-infrared (NIR) emission at 695\u00a0nm in the single-emissive-layer polymer light-emitting devices, respectively. The maximum external quantum efficiency ( EQE ) of 1.36% and highest radiant intensity ( R ) of 45\u00a0 \u03bc W\u00a0cm \u22122  were obtained in the complex B-doped devices, which are 13.6 and 2.6 times of those corresponding values in the complex A-doped devices. It indicates that appending dual donor-accepter frameworks in the heads of salophen is an efficient strategy to achieve NIR emission for their tetradentate platinum (II) complexes.",
        "keywords": "",
        "authors": [
            {
                "name": "Youming Zhang",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Fanyuan Meng",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Fanyuan Meng",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Caifa You",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Shengyi Yang",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Wenjing Xiong",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Shi-Jian Su",
                "org": "Institute of Polymer Optoelectronic Materials and Devices, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2017
    },
    "tQ1ynPLZ": {
        "id": "tQ1ynPLZ",
        "title": "Efficient near-infrared emitting tetradentate bis-cyclometalated platinum (IV) complexes for solution-processed polymer light-emitting diodes",
        "abstract": "Abstract   Two novel tetradentate bis-cyclometalated platinum (IV) complexes of TPA-2q-PtCl 2  and 3TPA-2q-PtCl 2  with C \u02c6 N*N \u02c6 C cyclometalated ligands and two coordinated chlorine atoms were synthesized and characterized. The crystal structure of TPA-2q-PtCl 2  shows a  trans -form irregular octahedral geometry by measurement of single-crystal X-ray diffraction, where two C \u02c6 N coordination moieties are twisted and two chlorine atoms are located on both sides of platinum atom. A medium absorption band in a range of 450\u2013474\u00a0nm is observed, which is assigned to the metal-to-ligand charge-transfer (MLCT) and intramolecular charge transfer (ILCT). And two obvious emission peaks at about 635 and 750\u00a0nm are displayed for both platinum (IV) complexes in 2-methyltetrahydrofuran solutions, which originate from the ILCT and MLCT characters to the lowest excited state. Using one of platinum (IV) complexes as a single dopant and a blend of poly(vinylcarbazole) as a host matrix, their single-emissive-layer polymer light-emitting diodes (PLEDs) exhibit an outstanding near-infrared emission with an electroluminescent (EL) peak of 750\u00a0nm. The better electroluminescent properties are obtained in the 3TPA-2q-PtCl 2  doped devices with an external quantum efficiency of 0.85% and a radiance of 164\u00a0\u03bcW/cm \u22122 . This is the first reported sample about tetradentate biscyclometalated platinum (IV) complexes used as organic NIR electroluminescent materials for promising application in PLEDs.",
        "keywords": "",
        "authors": [
            {
                "name": "Youming Zhang",
                "org": "Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, Department of Materials Chemistry, School of Materials Science and Engineering, Changzhou University, Changzhou 213164, China"
            },
            {
                "name": "Fanyuan Meng",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Fanyuan Meng",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Caifa You",
                "org": "Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, Department of Materials Chemistry, School of Materials Science and Engineering, Changzhou University, Changzhou 213164, China"
            },
            {
                "name": "Shengyi Yang",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Lin Xiong",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Wenjing Xiong",
                "org": "Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, Department of Materials Chemistry, School of Materials Science and Engineering, Changzhou University, Changzhou 213164, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, Department of Materials Chemistry, School of Materials Science and Engineering, Changzhou University, Changzhou 213164, China"
            },
            {
                "name": "Yafei Wang",
                "org": "Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, Department of Materials Chemistry, School of Materials Science and Engineering, Changzhou University, Changzhou 213164, China"
            },
            {
                "name": "Yong Pei",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Shi-Jian Su",
                "org": "Institute of Polymer Optoelectronic Materials and Devices, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China"
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2017
    },
    "gHtmPuIC": {
        "id": "gHtmPuIC",
        "title": "Near-Infrared Emitting Materials: Near-Infrared Emitting Materials via Harvesting Triplet Excitons: Molecular Design, Properties, and Application in Organic Light Emitting Diodes (Advanced Optical Materials 18/2018)",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Youming Zhang",
                "org": "Hong Kong Polytechnic University"
            },
            {
                "name": "Youming Zhang",
                "org": "Shenzhen University"
            },
            {
                "name": "Yafei Wang",
                "org": ""
            },
            {
                "name": "Jun Song",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province; College of Optoelectronic Engineering; Shenzhen University; Shenzhen 518060 P. R. China"
            },
            {
                "name": "Junle Qu",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province; College of Optoelectronic Engineering; Shenzhen University; Shenzhen 518060 P. R. China"
            },
            {
                "name": "Buhong Li",
                "org": "MOE Key Laboratory of OptoElectronic Science and Technology for Medicine; Fujian Provincial Key Laboratory for Photonics Technology; Fujian Normal University; Fuzhou Fujian 350007 P. R. China"
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            },
            {
                "name": "Wai-Yeung Wong",
                "org": "Department of Applied Biology and Chemical Technology; The Hong Kong Polytechnic University; Hung Hom Hong Kong P. R. China"
            },
            {
                "name": "Wai-Yeung Wong",
                "org": "Department of Applied Biology and Chemical Technology; The Hong Kong Polytechnic University; Hung Hom Hong Kong P. R. China"
            }
        ],
        "venue": "Advanced Optical Materials",
        "year": 2018
    },
    "ss3Hgpwa": {
        "id": "ss3Hgpwa",
        "title": "The synthesis and properties of the europium(III) complexes using trifluorene-phenanthroline derivative as ligand",
        "abstract": "Abstract   Two europium(III) complexes of Tfl-PIPEu(TTA) 3  and PIPEu(TTA) 3  (Tfl\u00a0=\u00a0alkyltrifluorene, PIP\u00a0=\u00a0phenyl-1H-imidazo[4,5- f ] [1,10]phenanthroline, TTA\u00a0=\u00a02-thenoyltrifluoroacetone) were synthesized, which contain an alkyltrifluorene unit or octyl unit, respectively. Their thermal, optophysical, electrochemical properties and dispersibility were investigated. The electroluminescence (EL) properties of Tfl-PIPEu(TTA) 3  and PIPEu(TTA) 3  were also examined. It was found that the Tfl-PIPEu(TTA) 3 -based devices have a better EL performance compared to PIPEu(TTA) 3 -based devices because Tfl-PIPEu(TTA) 3  exhibits a more matched energy levels with the polyvinylcarbazole:2-(4-biphenyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole (PVK-PBD) and better dispersibility in the PVK-PBD blend. The Tfl-PIPEu(TTA) 3 -based devices show a sharp red emission at 616\u00a0nm with a full width at half-maximum of 10\u00a0nm at the dopant concentrations from 1.0 to 8.0\u00a0wt% and a maximum brightness of 229\u00a0cd\u00a0m \u2212\u00a02  is obtained at 4.0\u00a0wt% doped concentration. The maximum brightness is 2.52 times higher than that of the PIPEu(TTA) 3 -based devices. Our work indicates that the introduction of an alkyltrifluorene unit can improve the device performance for its resulting europium(III) complexes.",
        "keywords": "",
        "authors": [
            {
                "name": "Junting Yu",
                "org": "Key Laboratory of Theoretical Organic Chemistry and Functional Molecule for Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, PR China"
            },
            {
                "name": "Manjun Xiao",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            }
        ],
        "venue": "Thin Solid Films",
        "year": 2016
    },
    "JLDGZk3y": {
        "id": "JLDGZk3y",
        "title": "Engineering the Interconnecting Position of Star-Shaped Donor-\u03c0-Acceptor Molecules Based on Triazine, Spirofluorene, and Triphenylamine Moieties for Color Tuning from Deep Blue to Green.",
        "abstract": "Pi-conjugated organic molecules featuring the donor-bridge-acceptor (D-\u03c0-A) structure have been widely used in semiconducting materials owing to their rigid structure, good thermal stability, excellent charge transfer, and high emission efficiency. To investigate the effect of the D-\u03c0-A molecular structure on the photophysical properties, in this contribution, three star-shaped D-\u03c0-A isomers based on the 2,4,6-triphenyl-1,3,5-triazine, spirofluorene, and triphenylamine moieties, that is, p-TFTPA, mp-TFTPA, and m-TFTPA, were synthesized by elaborately engineering the interconnecting position in the building-block units. The optophysical properties of these compounds were systematically explored by experiments and theory calculations. Definitively, changing the interconnecting position in these molecules played a significant role in the degree of \u03c0 conjugation, which resulted in tunable emission colors from deep blue to green. Moreover, these isomers were employed as emissive dopants in organic light-emitting diodes. The highest external quantum efficiency of 2.3\u2009% and current efficiency of 6.2\u2005cd\u2009A(-1) were achieved by using the p-TFTPA based device. This research demonstrates a feasible way to realize blue emitters by engineering D-\u03c0-A conjugation. ",
        "keywords": [
            "conjugation",
            "donor-acceptor systems",
            "interconnecting position",
            "photophysics",
            "solvatochromism"
        ],
        "authors": [
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Xiangtan University, Xiangtan City, Hunan, 411105, P.R. China. qiji830404@hotmail.com."
            },
            {
                "name": "Wanhui Liu",
                "org": "College of Chemistry, Xiangtan University, Xiangtan City, Hunan, 411105, P.R. China."
            },
            {
                "name": "Jiyong Deng",
                "org": "School of Chemistry and Chemical Engineering, Hunan Institute of Engineering, Xiangtan, 411104, P.R. China."
            },
            {
                "name": "Guohua Xie",
                "org": "Department of Chemistry, Wuhan University, Wuhan, Hubei, 430072, P.R. China. guohua.xie@whu.edu.cn."
            },
            {
                "name": "Yuanwei Liao",
                "org": "College of Chemistry, Xiangtan University, Xiangtan City, Hunan, 411105, P.R. China."
            },
            {
                "name": "Zuoming Qu",
                "org": "College of Chemistry, Xiangtan University, Xiangtan City, Hunan, 411105, P.R. China."
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Xiangtan University, Xiangtan City, Hunan, 411105, P.R. China."
            },
            {
                "name": "Yu Liu",
                "org": "College of Chemistry, Xiangtan University, Xiangtan City, Hunan, 411105, P.R. China."
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Xiangtan University, Xiangtan City, Hunan, 411105, P.R. China."
            }
        ],
        "venue": "Chemistry, an Asian journal",
        "year": 2016
    },
    "rPjs0fgC": {
        "id": "rPjs0fgC",
        "title": "Highly efficient blueish-green fluorescent OLEDs based on AIE liquid crystal molecules: from ingenious molecular design to multifunction materials",
        "abstract": "In order to seek the balance point between liquid crystallinity and high efficiency emission, two novel aggregation-induced emission-based (AIE) liquid crystal materials of TPE-PBN and TPE-2PBN, which contain a tetraphenylethene derivative as the emission core and a 4-cynobiphenyl moiety as the mesogenic unit, were designed and prepared. Both simple molecules showed a mesophase at high temperature as evidenced by polarised optical microscopy (POM), differential scanning calorimetry (DSC) and temperature-dependent X-ray diffraction (XRD). Simultaneously, TPE-PBN and TPE-2PBN presented clear AIE characteristics in the blueish-green region and achieved a high emission quantum efficiency of 71% and 83% in the solid state, respectively. Due to the self-assembly properties of thermotropic liquid crystals, both compounds showed higher hole mobilities in the annealed films than in pristine films. Employing TPE-PBN and TPE-2PBN as the emitting materials, both non-doped devices and doped devices were fabricated. The TPE-PBN-based doped OLEDs showed a better device performance with an external quantum efficiency (EQE) of 4.1% which is among the highest EQEs of blue AIE fluorescent OLEDs.",
        "keywords": "",
        "authors": [
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University,Xiangtan 411105,P. R. China"
            },
            {
                "name": "Yuanwei Liao",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University,Xiangtan 411105,P. R. China"
            },
            {
                "name": "Christopher P. Cabry",
                "org": "Department of Chemistry, University of York, Heslington,York,UK"
            },
            {
                "name": "Di Zhou",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University,Xiangtan 411105,P. R. China"
            },
            {
                "name": "Guohua Xie",
                "org": "Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Hubei Key Lab on Organic and Polymeric Optoelectronic Materials, Department of Chemistry, Wuhan University,Wuhan 430072,P. R. China"
            },
            {
                "name": "Zuoming Qu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application of the Ministry of Education, Xiangtan University,Xiangtan 411105,P. R. China"
            },
            {
                "name": "Duncan W. Bruce",
                "org": "Department of Chemistry, University of York, Heslington,York,UK"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, School of Materials Science & Engineering, Changzhou University,Changzhou 213164,P. R. China"
            }
        ],
        "venue": "Journal of Materials Chemistry C",
        "year": 2017
    },
    "VbjFA3e2": {
        "id": "VbjFA3e2",
        "title": "Near-Infrared Emitting Materials via Harvesting Triplet Excitons: Molecular Design, Properties, and Application in Organic Light Emitting Diodes",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Youming Zhang",
                "org": "Shenzhen University"
            },
            {
                "name": "Youming Zhang",
                "org": "Shenzhen University"
            },
            {
                "name": "Yafei Wang",
                "org": ""
            },
            {
                "name": "Jun Song",
                "org": ""
            },
            {
                "name": "Junle Qu",
                "org": ""
            },
            {
                "name": "Buhong Li",
                "org": "MOE Key Laboratory of OptoElectronic Science and Technology for Medicine Fujian Provincial Key Laboratory for Photonics Technology Fujian Normal University Fuzhou Fujian 350007 P. R. China"
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            },
            {
                "name": "Wai-Yeung Wong",
                "org": "Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Hung Hom Hong Kong P. R. China"
            },
            {
                "name": "Wai-Yeung Wong",
                "org": "Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Hung Hom Hong Kong P. R. China"
            }
        ],
        "venue": "Advanced Optical Materials",
        "year": 2018
    },
    "hXij6zL4": {
        "id": "hXij6zL4",
        "title": "Dinuclear platinum complexes containing aryl-isoquinoline and oxadiazole-thiol with an efficiency of over 8.8%: in-depth investigation of the relationship between their molecular structure and near-infrared electroluminescent properties in PLEDs",
        "abstract": "Two novel dinuclear platinum complexes of (2niq)2Pt2(\u03bc-C8PhOXT)2 and (piq)2Pt2(\u03bc-PhOXT)2 were synthesized and characterized, where 2niq is 2-naphthyl-isoquinolinate, piq is 1-pheny-isoquinolinate, and \u03bc-C8PhOXT and \u03bc-PhOXT are anions of 5-(4-octylphenyl)-1,3,4-oxadiazole-2-thiol and 5-phenyl-1,3,4-oxadiazole-2-thiol, respectively. The Pt\u2013Pt bond was confirmed by the (piq)2Pt2(\u03bc-PhOXT)2 single crystal. A high-efficiency NIR electroluminescence peak at about 704 nm was observed for this (2niq)2Pt2(\u03bc-C8PhOXT)2 in the solution-processed PLEDs with a notable external quantum efficiency (EQE) of 8.86% and an irradiate of 986 \u03bcW cm\u22122 at 9 wt% dopant concentration. Moreover, the efficiency roll-off was efficiently restrained, with an EQE of 5.22% at a current density of 100 mA cm\u22122 and 8.47% at 12 wt% dopant concentration.",
        "keywords": "",
        "authors": [
            {
                "name": "Wenjing Xiong",
                "org": "College of Chemistry, Xiangtan University,Xiangtan 411105,People's Republic of China"
            },
            {
                "name": "Fanyuan Meng",
                "org": "College of Chemistry, Xiangtan University,Xiangtan 411105,People's Republic of China"
            },
            {
                "name": "Fanyuan Meng",
                "org": "College of Chemistry, Xiangtan University,Xiangtan 411105,People's Republic of China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Xiangtan University,Xiangtan 411105,People's Republic of China"
            },
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Xiangtan University,Xiangtan 411105,People's Republic of China"
            },
            {
                "name": "Pu Wang",
                "org": "College of Chemistry, Xiangtan University,Xiangtan 411105,People's Republic of China"
            },
            {
                "name": "Youming Zhang",
                "org": "College of Chemistry, Xiangtan University,Xiangtan 411105,People's Republic of China"
            },
            {
                "name": "Qiang Tao",
                "org": "College of Chemistry, Xiangtan University,Xiangtan 411105,People's Republic of China"
            },
            {
                "name": "Shi-Jian Su",
                "org": "State Key Laboratory of Luminescent Materials and Devices, South China University of Technology,Guangzhou 510640,People's Republic of China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Xiangtan University,Xiangtan 411105,People's Republic of China"
            }
        ],
        "venue": "Journal of Materials Chemistry C",
        "year": 2016
    },
    "OBMffiX4": {
        "id": "OBMffiX4",
        "title": "Molecular isomeric engineering of naphthyl-quinoline-containing dinuclear platinum complexes to tune emission from deep red to near infrared",
        "abstract": "Four isomeric dinuclear platinum complexes of (C^N)2Pt2(\u03bc-OXT)2 are synthesized and characterized with different C^N cyclometalating ligands and the same ancillary ligand of 5-(4-octylphenyl)-1,3,4-oxadiazole-2-thiol (\u03bc-OXT). These isomeric C^N ligands are 1-naphthyl-1-isoquinoline (niq), 2-naphthyl-1-isoquinoline (2niq), 1-naphthyl-2-quinoline (nq) and 2-naphthyl-2-quinoline (2nq). The isomeric effect on the photophysical, electrochemical and electroluminescence properties of (C^N)2Pt2(\u03bc-OXT)2 was systematically studied. It is found that the emissions were easy to tune from deep red to near infrared for (C^N)2Pt2(\u03bc-OXT)2 by changing the C^N isomers. Furthermore, the complexes with 2-naphthyl presented better electroluminescence (EL) properties than the complexes with 1-naphthyl in these solution-processable polymeric light-emitting devices. In contrast to the (2nq)2Pt2(\u03bc-OXT)2-doped devices displaying a deep-red emission peaked at 686 nm with an external quantum efficiency (EQE) of 3.21%, the (2niq)2Pt2(\u03bc-OXT)2-doped devices exhibited a near-infrared emission peaked at 704 nm with a significantly increased EQE of 8.86% and a radiant emittance of 986 \u03bcW cm\u22122. Our research provides an efficient strategy to tune emission from deep red to near infrared by a simple isomeric engineering of dinuclear platinum(II) complexes.",
        "keywords": "",
        "authors": [
            {
                "name": "Wenjing Xiong",
                "org": "College of Chemistry, Xiangtan University,Xiangtan 411105,People's Republic of China"
            },
            {
                "name": "Fanyuan Meng",
                "org": "College of Chemistry, Xiangtan University,Xiangtan 411105,People's Republic of China"
            },
            {
                "name": "Fanyuan Meng",
                "org": "College of Chemistry, Xiangtan University,Xiangtan 411105,People's Republic of China"
            },
            {
                "name": "Caifa You",
                "org": "College of Chemistry, Xiangtan University,Xiangtan 411105,People's Republic of China"
            },
            {
                "name": "Pu Wang",
                "org": "College of Chemistry, Xiangtan University,Xiangtan 411105,People's Republic of China"
            },
            {
                "name": "Junting Yu",
                "org": "School of Chemistry and Chemical Engineering, Hunan University of Science and Technology,Xiangtan,China"
            },
            {
                "name": "Xiugang Wu",
                "org": ""
            },
            {
                "name": "Yong Pei",
                "org": "College of Chemistry, Xiangtan University,Xiangtan 411105,People's Republic of China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Xiangtan University,Xiangtan 411105,People's Republic of China"
            },
            {
                "name": "Yafei Wang",
                "org": ""
            },
            {
                "name": "Shijian Su",
                "org": "State Key Laboratory of Luminescent Materials and Devices, South China University of Technology,Guangzhou 510640,People's Republic of China"
            }
        ],
        "venue": "Journal of Materials Chemistry C",
        "year": 2019
    },
    "IBuvwExs": {
        "id": "IBuvwExs",
        "title": "Triphenylamine-functionalized iridium(III) complexes for near-infrared phosphorescent organic light emitting diodes",
        "abstract": "Abstract   With the aim of enhancing the efficiency of near infrared (NIR) organic light-emitting devices (OLEDs), two new triphenylamine-functionalized NIR iridium(III) complexes by covalently attaching the functional moieties ( t Bu and F) complexes (tBuTPA-BTz-Iq) 2 Irpic and (FTPA-BTz-Iq) 2 Irpic were designed and synthesized (TPA\u202f=\u202ftriphenylamine; BTz\u202f=\u202fbenzotriazole; Iq\u202f=\u202fisoquinoline). It was found that compared to their parent iridium complex (TPA-BTz-Iq) 2 Irpic, the addition of either butyl or fluorine groups into the ligand play an important role in improving the optophysical and electroluminescent characteristics. In solution-processed phosphorescent OLEDs, the (tBuTPA-BTz-Iq) 2 Irpic-based devices achieved a maximum external quantum efficiency ( EQE   max  ) of 0.66% at 716\u202fnm, while the (FTPA-BTz-Iq) 2 Irpic-based devices achieved an  EQE   max   of 0.48% at 710\u202fnm. The  EQE   max   level is 2.28 or 1.65 times higher than that in the (TPA-BTz-Iq) 2 Irpic-based devices (0.29% at 712\u202fnm), respectively.",
        "keywords": "",
        "authors": [
            {
                "name": "Junting Yu",
                "org": "Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, 411201, PR China"
            },
            {
                "name": "Chao Xu",
                "org": "College of Chemistry, Xiangtan University, Xiangtan, 411105, PR China"
            },
            {
                "name": "Fanyuan Meng",
                "org": "College of Chemistry, Xiangtan University, Xiangtan, 411105, PR China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Xiangtan University, Xiangtan, 411105, PR China"
            },
            {
                "name": "Maoqiu Li",
                "org": "Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, 411201, PR China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "School of Materials Science and Engineering, Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou, 213164, PR China"
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2019
    },
    "h5IxAMxQ": {
        "id": "h5IxAMxQ",
        "title": "Near-infrared emission from binuclear platinum (II) complexes containing pyrenylpyridine and pyridylthiolate units: Synthesis, photo-physical and electroluminescent properties",
        "abstract": "Abstract   Two novel binuclear platinum (II) complexes of (Rpypy) 2 Pt 2 (pyt) 2  were synthesized and characterized, in which Rpypy represents 2-(1-pyrenyl) pyridine (pypy) and 2-(7- tert -butyl-1-pyrenyl)pyridine (  t  Bupypy), pyt refers to pyridyl-2-thiolate, respectively. Their binuclear framework was evidenced by the single crystal of (pypy) 2 Pt 2 (pyt) 2  with a short Pt Pt bond distance of 2.8814(3) A. The intense near-infrared (NIR) emission peaks at 692 and 753\u00a0nm were exhibited for both dinuclear platinum complexes, which is similar to the emission of the mono-nuclear platinum complex of (pypy)Pt(acac) under photo-excitation. However, a red-shifted NIR electroluminescence (EL) peaked at 692\u00a0nm with a shoulder at 753\u00a0nm was observed in their doped polymer light-emitting diodes using PVK/OXD-7 as the host blend, which presented intrinsic character of MMLCT. Better EL performances with the maximum external quantum efficiency of 0.74% and a radiate emittance of 123.4 \u03bcw.cm \u22122  were obtained in the (  t  Bupypy) 2 Pt 2 (pyt) 2  doped device. To our best knowledge, this is a first reported example on the NIR EL of binuclear platinum complex using pyridyl-2-thiolate as auxiliary ligand.",
        "keywords": "",
        "authors": [
            {
                "name": "Ning Su",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Fanyuan Meng",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Fanyuan Meng",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Pu Wang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Xia Liu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Mengbing Zhu",
                "org": "School of Materials Science and Engineering, Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou 213164, PR China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "School of Materials Science and Engineering, Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou 213164, PR China"
            },
            {
                "name": "Shi-Jian Su",
                "org": "Institute of Polymer Optoelectronic Materials and Devices, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, PR China"
            },
            {
                "name": "Junting Yu",
                "org": "School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, 411201, PR China"
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2017
    },
    "XJXRxGbt": {
        "id": "XJXRxGbt",
        "title": "Linearly polarized electroluminescence from ionic iridium complex-based metallomesogens: the effect of aliphatic-chain on their photophysical properties",
        "abstract": "Directly polarized organic light emitting diodes (OLEDs) have the potential to significantly improve the efficiency and reduce the cost of liquid-crystal displays (LCDs) among other applications. However, fluorescent liquid crystals are currently used to achieve this, while phosphorescent emitters would further improve efficiency. To this end, the metallomesogens based on ionic iridium complexes bearing different aliphatic chains substituent, named 7a and 7b, were designed and prepared in this contribution. Both iridium complexes showed smectic mesophase evidenced by differential scanning calorimetry, polarized optical microscopy and X-ray diffraction. Deep-red emission was observed for the iridium complexes in solution and solid state, and complex 7a clearly presented aggregation-induced emission (AIE) behavior in THF-water solvent mixture. Non-doped polarized OLEDs employing complex 7a or 7b as emitter were fabricated and direct linearly polarized electroluminescence with a polarization ratio of 4 was achieved, which is the highest ratio reported for metallomesogens-based phosphorescent OLEDs. Importantly, the choice of linker between the core complex and mesogenic pendent groups is key to achieve distinctive polarization of electroluminescence and AIE. These results are a first step towards the development phosphorescent OLEDs able to efficiently produce polarized electroluminescence.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiugang Wu",
                "org": "Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, School of Materials Science & Engineering, Changzhou University,Changzhou 213164,P. R. China"
            },
            {
                "name": "Guohua Xie",
                "org": "Department of Chemistry, Hubei Key Lab on Organic and Polymeric Optoelectronic Materials, Wuhan University,Wuhan 430072,People's Republic of China"
            },
            {
                "name": "Christopher P. Cabry",
                "org": "Department of Chemistry, University of York, Heslington,York,UK"
            },
            {
                "name": "Xiaoyu Xu",
                "org": "School of Chemistry, University of Birmingham,Birmingham B15 2TT,UK"
            },
            {
                "name": "Stephen J. Cowling",
                "org": ""
            },
            {
                "name": "Duncan W. Bruce",
                "org": "Department of Chemistry, University of York, Heslington,York,UK"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, School of Materials Science & Engineering, Changzhou University,Changzhou 213164,P. R. China"
            },
            {
                "name": "Etienne Baranoff",
                "org": "School of Chemistry, University of Birmingham,Birmingham B15 2TT,UK"
            },
            {
                "name": "Yafei Wang",
                "org": "Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, School of Materials Science & Engineering, Changzhou University,Changzhou 213164,P. R. China"
            }
        ],
        "venue": "Journal of Materials Chemistry C",
        "year": 2018
    },
    "YsK6Y09f": {
        "id": "YsK6Y09f",
        "title": "Benzotriazole-containing donor\u2013acceptor\u2013acceptor type cyclometalated iridium(III) complex for solution-processed near-infrared polymer light emitting diodes",
        "abstract": "Abstract   A novel near-infrared-emitting cyclometalated iridium(III) complex of (CH 3 OTPA-BTz-Iq) 2 Irpic containing benzotriazole unit with a donor\u2013acceptor\u2013acceptor (D-A-A) chromophore was synthesized and characterized. The optophysical, electrochemical and electroluminescent characteristics were primarily studied. A near-infrared emission peaked at 716\u00a0nm with a shoulder at 790\u00a0nm was exhibited in the (CH 3 OTPA-BTz-Iq) 2 Irpic dichloromethane solution at 298\u00a0K. In its optimized solution-processed polymer light-emitting diodes, a near-infrared electroluminescent emission peaked at 723\u00a0nm with a shoulder at 780\u00a0nm was observed with a maximum external quantum efficiency of 0.41% at 8.14\u00a0mA\u00a0cm \u22122 . This work indicates that introducing appropriate D and A units to develop D-A-A structure is an efficient approach to construct near-infrared-emitting iridium(III) complex in the polymer light-emitting diodes with suppressive efficiency roll-off.",
        "keywords": "",
        "authors": [
            {
                "name": "Junting Yu",
                "org": "Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, PR China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Fanyuan Meng",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Kun Lv",
                "org": "Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, PR China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Shijian Su",
                "org": "Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology, Guangzhou 510640, PR China"
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2016
    },
    "yDeDIpnX": {
        "id": "yDeDIpnX",
        "title": "Achieving near-infrared emission in platinum(II) complexes by using an extended donor-acceptor-type ligand.",
        "abstract": "A series of C^N ligands with donor\u2013acceptor (D\u2013A) frameworks, i.e. TPA-BTPy, TPA-BTPy-Fl and Fl(TPA-BTPy)2, as well as their mono- and di-nuclear platinum(II) complexes of (TPA-BTPy)Pt(pic), (TPA-BTPy-Fl)Pt(pic) and [Fl(TPA-BTPy)2]Pt2(pic)2 are respectively designed and synthesized, in which triphenylamine (TPA) and fluorene (Fl) are used as the D units, 4-(pyrid-2-yl)benzothiadiazole (BTPy) as the A unit, and the picolinate anion (pic) as the auxiliary ligand. Their thermal, photophysical and electrochemical characteristics were investigated. Compared to mono-nuclear platinum complexes and their free ligands, this dinuclear one of [Fl(TPA-BTPy)2]Pt2(pic)2 shows an obvious interaction from the platinum atom to ligand and dual emission peaks at 828 and 601 nm in thin films. Upon oxidation with antimony pentachloride in dichloromethane, charge transfer transitions between the platinum and ligand are observed for the three complexes. The single-emissive-layer polymer light-emitting devices doped with [Fl(TPA-BTPy)2]Pt2(pic)2 display a strong electroluminescence with dual emission peaks at 780 and 600 nm at a dopant concentration over 4 wt%. A maximum external quantum efficiency of 0.02% with a radiance of 59 \u03bcW cm\u22122 is obtained in the device at 30 wt% dopant concentration. This work indicates that the use of an extended D\u2013A-type ligand is an effective strategy to achieve NIR emission for platinum complexes in PLEDs.",
        "keywords": "",
        "authors": [
            {
                "name": "Youming Zhang",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Fanyuan Meng",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Fanyuan Meng",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Jian-Hong Tang",
                "org": "Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences,Beijing 100190,China"
            },
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Caifa You",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Yu Liu",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Yu-Wu Zhong",
                "org": "Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences,Beijing 100190,China"
            },
            {
                "name": "Shijian Su",
                "org": "Institute of Polymer Optoelectronic Materials and Devices, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology,Guangzhou 510640,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            }
        ],
        "venue": "Dalton Transactions",
        "year": 2016
    },
    "A6rbxyoZ": {
        "id": "A6rbxyoZ",
        "title": "Synthesis and optoelectronic properties of dinuclear iridium (III) complexes containing deep blue fluorescence chromophore in the single-emissive-layer WPLEDs",
        "abstract": "Abstract   To explore the influence of molecular structure on formation excimer and obtain high efficiency white polymer light-emitting devices (WPLEDs), two novel blue-emitting dinuclear cyclometalated iridium (III) complexes, namely C 8 DBCzC 6 -DF 2 Ir(pic) and DPy(TPA)-C 6 DBCzC 6 -DF 2 Ir(pic), have been successfully synthesized and characterized, in which DBCz is 3,6-diphenyl-carbazole bridged core, DPy(TPA) is 4,4\u2032-di(pyren-1-yl)triphenylamine deep blue-emitting fluorescent chromophore, DF 2 Ir(pic) is dinuclear iridium (III) bis[(4,6-difluorophenyl)-pyridinato-N,C 2\u2032 ](picolinate) blue-emitting phosphorescent chromophore, and C 6  is an nonconjugated dioxyhexyloxy linkage, respectively, and each parts of molecular skeleton are wired through nonconjugated ether linkage. Their thermal, electrochemical and optophysical properties were primarily investigated. Near white light emission were obtained in the C 8 DBCzC 6 -DF 2 Ir(pic)-doped devices using a blend of polyvinylcarbazole (PVK) and 2-(4-biphenyl)-5-(4- tert -butylphenyl)-1,3,4-oxadiazole (PBD) as a host matrix at dopant concentrations of 1\u00a0wt%. However, after triphenylamine functionalized pyrene DPy(TPA) replaced the alkyl chain C 6  unit, at first unexpected, substitution effect occurs, more stable white light emissions with the CIE coordinates of (0.297\u00a0\u00b1\u00a00.009, 0.345\u00a0\u00b1\u00a00.007) and a maximum brightness of 961\u00a0cd/m 2  were observed in the same device at the doping concentrations of 8\u00a0wt% under different applied voltages from 8 to 13\u00a0V. The results indicate that aggregation/excimer emissions of iridium (III) complexes can be effectively tuned by inserting a deep blue fluorescent chromophore into the dual picolinic acid derivative, and it aslo be an efficient way to get white-emitting WPLEDs.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhaoran Hao",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan, 411105, China"
            },
            {
                "name": "Haigang Jiang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan, 411105, China"
            },
            {
                "name": "Yu Liu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan, 411105, China"
            },
            {
                "name": "Youming Zhang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan, 411105, China"
            },
            {
                "name": "Junting Yu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan, 411105, China"
            },
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan, 411105, China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan, 411105, China"
            },
            {
                "name": "Shi-Jian Su",
                "org": "State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhouv, 510640, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "School of Materials Science and Engineering, Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Changzhou, 213164, China"
            }
        ],
        "venue": "Tetrahedron",
        "year": 2016
    },
    "GQkjtnr2": {
        "id": "GQkjtnr2",
        "title": "Dinuclear platinum(II) complex dominated by a zig-zag-type cyclometalated ligand: a new approach to realize high-efficiency near infrared emission",
        "abstract": "Two new zig-zag type di- and mono-nuclear platinum(II) complexes of (BuPh-BDIQ)Pt2(dpm)2 and (BuPh-BDIQ)Ptdpm were synthesized and characterized by using a zig-zag type cyclometalating ligand 3,10-di(tert-butyl)-5,12-bis(4-(tert-butyl)phenyl)-benzodiisoquinoline (BuPh-BDIQ). Their single-crystal structures, and photophysical, electrochemical and electroluminescent properties were primarily investigated. Compared with (BuPh-BDIQ)Ptdpm, (BuPh-BDIQ)Pt2(dpm)2 exhibited a significantly increased photoluminescent efficiency of 3.64% and a red-shifted near-infrared (NIR) emission peak at 718 nm owing to its enhanced rigid planar structure in a nitrogen atmosphere. As a result, only (BuPh-BDIQ)Pt2(dpm)2 presented NIR electroluminescent emission in a doped polymeric light-emitting diode. The highest external quantum efficiency of 0.97% and a radiant intensity of 146 \u03bcW cm\u22122 were observed for the device at 2 wt% dopant concentration, which is higher than the values of previous NIR-emitting di-nuclear platinum complexes constructed with cyclometalated ligands. Furthermore, efficiency roll-off was efficiently inhibited. This indicates that high-efficiency NIR-emitting di-nuclear platinum complexes can be obtained by designing a zig-zag type C^N\u2013C^N tetradentate cyclometalating ligand with a big rigid planar saw band.",
        "keywords": "",
        "authors": [
            {
                "name": "Shengyi Yang",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Fanyuan Meng",
                "org": "Institute of Polymer Optoelectronic Materials and Devices, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology,Guangzhou 510640,China"
            },
            {
                "name": "Xiugang Wu",
                "org": ""
            },
            {
                "name": "Zheng Yin",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Xianzhi Liu",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Caifa You",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Shi-Jian Su",
                "org": "Institute of Polymer Optoelectronic Materials and Devices, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology,Guangzhou 510640,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            }
        ],
        "venue": "Journal of Materials Chemistry C",
        "year": 2018
    },
    "vf6aJ81s": {
        "id": "vf6aJ81s",
        "title": "Efficient polymer solar cells based on a new quinoxaline derivative with fluorinated phenyl side chain",
        "abstract": "A novel donor\u2013\u03c0\u2013acceptor (D\u2013\u03c0\u2013A) type polymer of PBDTT-DTFPQx composed of a medium electron-donating 5,8-dialkylthienyl substituted benzo[1,2-b:4,5-b\u2032]dithiophene (BDTT) moiety and a strong electron-accepting 4-fluorophenyl substituted 6,7-dioctyloxyquinoxaline (FPQx) with thiophene \u03c0-bridge units was synthesized and characterized, as a donor material for polymer solar cells (PSCs). This polymer exhibits a low optical bandgap of 1.66 eV with an absorption onset of 745 nm, a low-lying HOMO energy level of \u22125.52 eV, and a hole mobility of 5.05 \u00d7 10\u22124 cm2 V\u22121 s\u22121. Compared to the reported analogues, PSCs based on PBDTT-DTFPQx/PC71BM demonstrated an outstanding fill factor (FF) value. With an optimized blend ratio of PBDT-TFQ\u2006:\u2006PC71BM (1\u2006:\u20064, w/w), a high power conversion efficiency (PCE) of 7.2% was obtained, with an open-circuit voltage (Voc) of 0.87 V, a short-circuit current (Jsc) of 11.4 mA cm\u22122, and a FF of up to 73% under AM 1.5G irradiation. The results demonstrate that the introduction of two fluoride atoms onto 4-positions of the phenyl group at the quinoxaline unit by side-chain engineering into the BDTT-alt-DTQx type polymers would be a feasible approach to improve photovoltaic properties in PSCs.",
        "keywords": "",
        "authors": [
            {
                "name": "Qunping Fan",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Huanxiang Jiang",
                "org": "Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences,Qingdao 266101,China"
            },
            {
                "name": "Yu Liu",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Wenyan Su",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            },
            {
                "name": "Renqiang Yang",
                "org": "Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences,Qingdao 266101,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education,Xiangtan 411105,China"
            }
        ],
        "venue": "Journal of Materials Chemistry C",
        "year": 2016
    },
    "ZWg69mJI": {
        "id": "ZWg69mJI",
        "title": "Synthesis and characterization of novel indacenodithiophene-based narrow band-gap polymers with pendant isoindigo units for polymer solar cells",
        "abstract": "Abstract   Two novel indacenodithiophene (IDT) based donor-acceptor (D-A) narrow band-gap polymers PIDTBDTID and PIDTBDT(ID) 2  were designed and synthesized, where one/two isoindigo (ID) moieties were introduced into the backbone as the acceptor unit. The optical, thermal, electrochemical and photovoltaic properties have been investigated in detail. The PIDTBDTID containing one ID unit exhibited better light-harvesting properties and charge transport properties. On the other hand, the PIDTBDT(ID) 2  with two ID units displayed lower the highest occupied molecular orbital energy levels (HOMO). Using these polymers as electron donors and (6,6)-phenyl-C 71 -butyric acid methyl ester (PC 71 BM) as electron acceptor, polymer solar cells (PSCs) based on PIDTBDTID exhibited better photovoltaic performance with a power conversion efficiency (PCE) of 2.66%, an open-circuit voltage ( V OC  ) of 0.87\u00a0V and an enhanced short-circuit current ( J SC  ) of 7.24\u00a0mA\u00a0cm \u22122 . While the PIDTBDT(ID) 2 -based PSCs shown a PCE of 2.50%, an improved  V OC   of 0.93\u00a0V and an  J SC   of 6.34\u00a0mA\u00a0cm \u22122 .",
        "keywords": "",
        "authors": [
            {
                "name": "Wenhong Peng",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Hua Tan",
                "org": ""
            },
            {
                "name": "Hua Tan",
                "org": ""
            },
            {
                "name": "Manjun Xiao",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Manjun Xiao",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Jianhua Chen",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Qiang Tao",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Xiongwei Duan",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Yafei Wang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Yu Liu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Renqiang Yang",
                "org": "Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            }
        ],
        "venue": "European Polymer Journal",
        "year": 2016
    },
    "YQuY9kvy": {
        "id": "YQuY9kvy",
        "title": "Tuning the fused aromatic rings to enhance photovoltaic performance in wide band-gap polymer solar cells",
        "abstract": "Abstract   Two novel wide band-gap polymers of PFT1 and PFT2 were designed as the alternative to P3HT in organic electronics, in which the fused aromatic rings were utilized and altered to tune their molecular co-planarity and photovoltaic performance in solar cells. As observed, although PFT1 exhibited strong inter-molecular interaction, slightly twisted molecular structure was observed, thus leading to an inferior PCE value of 1.95% in BHJ solar cells and holes mobility of 2.04\u00a0\u00d7\u00a010 \u22122 \u00a0cm 2 \u00a0V \u22121 \u00a0s \u22121  in OFETs in contrast to its isomeric polymer PBTFT. On the other hand, when the fused thiophene rings was tuned to construct PFT2, much planar polymer backbone was achieved, finally leading to the maximum PCE value of 3.34% in polymer solar cells and much enhanced holes mobility up to 3.93\u00a0\u00d7\u00a010 \u22122 \u00a0cm 2 \u00a0V \u22121 \u00a0s \u22121  in OFETs. Our results here further indicated that tuning the fused aromatic rings in polymer backbone could improve their charge transfer properties and enhance their photovoltaic performance in solar cells significantly.",
        "keywords": "",
        "authors": [
            {
                "name": "Dongfeng Dang",
                "org": "School of Science, Xi'an Jiao Tong University, Xi'an 710049, PR China"
            },
            {
                "name": "Jinxiang Chen",
                "org": "Institute of Polymer Optoelectronic Materials & Devices, State Key Laboratory of Luminescent Materials & Devices, South China University of Technology, Guangzhou 510640, PR China"
            },
            {
                "name": "Pei Zhou",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Linrui Duan",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Linrui Duan",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Xichang Bao",
                "org": "Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, PR China"
            },
            {
                "name": "Renqiang Yang",
                "org": "Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, PR China"
            },
            {
                "name": "Junwu Chen",
                "org": "Institute of Polymer Optoelectronic Materials & Devices, State Key Laboratory of Luminescent Materials & Devices, South China University of Technology, Guangzhou 510640, PR China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            }
        ],
        "venue": "Polymer",
        "year": 2016
    },
    "LmOqtAQj": {
        "id": "LmOqtAQj",
        "title": "Wide bandgap copolymers with vertical benzodithiophene dicarboxylate for high-performance polymer solar cells with an efficiency up to 7.49%",
        "abstract": "In aiming to build novel wide band-gap high-performance photovoltaic donor materials, a vertical benzo[1,2-b:4,5-b\u2032]dithiophene-2,6-dicarboxylate (V-BDTC) with a weak electron-withdrawing character was primarily developed. And its wide band-gap (WBG) copolymers PV-BDTC1 and PV-BDTC2 were designed and synthesized, which contain a traditional electron-donating unit of 4,8-disubstituted benzo[1,2-b:4,5-b\u2032] dithiophene (BDT) derivative with diethylhexyloxy for the former and diethylhexylthiophenyl for the latter. It is found that the weak electron-withdrawing V-BDTC unit endows its copolymers with a WBG up to 2.09 eV and a deep HOMO energy level of \u223c5.67 eV. Furthermore, PV-BDTC2 exhibits much better photovoltaic properties than PV-BDTC1 in the solution-processing polymer solar cells (PSCs) with a higher open-circuit voltage (Voc) of 1.03 V and an increased power conversion efficiency (PCE) of 7.49%. To the best of our knowledge, this PCE value is the highest level recorded for copolymers with a WBG over 2.0 eV in the PSCs to date, along with a remarkable Voc over 1.0 V. This work provides a feasible strategy to develop a novel promising electron-withdrawing building block and its high-performance WBG copolymers based on the BDT unit.",
        "keywords": "",
        "authors": [
            {
                "name": "Qiang Tao",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University,Xiangtan 411105,China"
            },
            {
                "name": "Tao Liu",
                "org": ""
            },
            {
                "name": "Linrui Duan",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University,Xiangtan 411105,China"
            },
            {
                "name": "Linrui Duan",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University,Xiangtan 411105,China"
            },
            {
                "name": "Yufeng Cai",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University,Xiangtan 411105,China"
            },
            {
                "name": "Wenjing Xiong",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University,Xiangtan 411105,China"
            },
            {
                "name": "Pu Wang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University,Xiangtan 411105,China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University,Xiangtan 411105,China"
            },
            {
                "name": "Gangtie Lei",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University,Xiangtan 411105,China"
            },
            {
                "name": "Yong Pei",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University,Xiangtan 411105,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University,Xiangtan 411105,China"
            },
            {
                "name": "Renqiang Yang",
                "org": "Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences,Qingdao 266101,China"
            },
            {
                "name": "Yanming Sun",
                "org": "Heeger Beijing Research and Development Center, School of Chemistry and Environment, Beihang University,Beijing 100191,China"
            }
        ],
        "venue": "Journal of Materials Chemistry",
        "year": 2016
    },
    "vMILMctL": {
        "id": "vMILMctL",
        "title": "D-A(1)-D-A(2) Copolymers with Extended Donor Segments for Efficient Polymer Solar Cells",
        "abstract": "",
        "keywords": [
            "biological sciences"
        ],
        "authors": [
            {
                "name": "qiang tao",
                "org": ""
            },
            {
                "name": "yuxin xia",
                "org": ""
            },
            {
                "name": "xiaofeng xu",
                "org": ""
            },
            {
                "name": "svante hedstrom",
                "org": ""
            },
            {
                "name": "olof backe",
                "org": ""
            },
            {
                "name": "david i james",
                "org": ""
            },
            {
                "name": "petter persson",
                "org": ""
            },
            {
                "name": "eva olsson",
                "org": ""
            },
            {
                "name": "olle inganas",
                "org": ""
            },
            {
                "name": "lintao hou",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            },
            {
                "name": "ergang wang",
                "org": ""
            }
        ],
        "venue": "Macromolecules",
        "year": 2015
    },
    "vElMv56j": {
        "id": "vElMv56j",
        "title": "Isomeric organic semiconductors containing fused-thiophene cores: molecular packing and charge transport.",
        "abstract": "Isomeric TF1 and TF2 with highly fused thiophene cores were designed and synthesized here, in which a highly planar molecular structure was obtained for TF1 with the face-to-face sulfur atoms in the lateral region and a twisted molecular backbone was observed for TF2 with the back-to-back sulfur atoms. It is worth noting that different intermolecular interactions dominated in TF1 and TF2 caused by their isomeric thiophene cores, in which strong \u03c0-\u03c0 stacking was achieved for TF1, whereas sulphur-involved nonbonding intermolecular interactions dominated in TF2, leading to the different fluorescence behaviors and also the altered liquid crystalline phases. Finally, typical P-type charge transport behaviors were achieved in both TF1- and TF2-based solution-processed OFETs. Also owing to the much ordered molecular packing in TF1, a higher charge carrier mobility of 3.7 \u00d7 10-3 cm2 V-1 s-1 was achieved for TF1-based OFETs compared to TF2-based OFETs.",
        "keywords": "",
        "authors": [
            {
                "name": "Dongfeng Dang",
                "org": "School of Science, MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiao Tong University, Xi'an 710049, P. R. China. dongfengdang@xjtu.edu.cn and Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, P. R. China. zhuwg18@126.com."
            },
            {
                "name": "Pei Zhou",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, P. R. China. zhuwg18@126.com."
            },
            {
                "name": "Yong Wu",
                "org": "School of Science, MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiao Tong University, Xi'an 710049, P. R. China. dongfengdang@xjtu.edu.cn."
            },
            {
                "name": "Yanzi Xu",
                "org": "School of Science, MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiao Tong University, Xi'an 710049, P. R. China. dongfengdang@xjtu.edu.cn."
            },
            {
                "name": "Ying Zhi",
                "org": "School of Science, MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiao Tong University, Xi'an 710049, P. R. China. dongfengdang@xjtu.edu.cn."
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, P. R. China. zhuwg18@126.com and School of Materials Science and Engineering, Changzhou University, Changzhou 213164, P. R. China."
            }
        ],
        "venue": "Physical chemistry chemical physics : PCCP",
        "year": 2018
    },
    "iBR0VeJO": {
        "id": "iBR0VeJO",
        "title": "Synthesis and characterization of D-A-A type regular terpolymers with narrowed band-gap and their application in high performance polymer solar cells",
        "abstract": "Abstract   Two novel D-A-A type regular terpolymers of PBDT-DTQ and PIDT-DTQ were designed and synthesized, in which benzodithiophene and indacenodithiophene building blocks were employed as the D unit, and quinoxaline building block was introduced as the A unit. Owing to the strong intra-molecular charge transfer effect in polymer backbone, much broader absorption spectra covering from 320 to 800\u00a0nm with the narrowed band-gap were obtained for the developed D-A-A type polymers in contrast to their corresponding D-A type polymers. On the other hand, compared with PBDT-DTQ, PIDT-DTQ exhibited a deeper HOMO energy level and also higher charge carrier mobility. To investigate the photovoltaic properties of PBDT-DTQ and PIDT-DTQ in detail, bulk hetero-junction polymer solar cells with a structure of ITO/PEDOT: PSS/Active Layer/Ca/Al were fabricated. PBDT-DTQ-based solar cells exhibited a moderate PCE value of 3.84%, however, an increased  J  sc  of 11.42\u00a0mA/cm 2 ,  V  oc  of 0.86\u00a0V and  FF  of 65.77% was achieved for PIDT-DTQ-based device, leading to the maximum PCE up to 6.41%. Our results here demonstrated that using the regular terpolymers as electron donor materials could be an efficient way to broaden the absorption of polymers and improve the photovoltaic performance of PSCs.",
        "keywords": "",
        "authors": [
            {
                "name": "Dongfeng Dang",
                "org": "School of Science, Xi'an Jiao Tong University, Xi'an, 710049, PR China"
            },
            {
                "name": "Xiaochi Wang",
                "org": "School of Science, Xi'an Jiao Tong University, Xi'an, 710049, PR China"
            },
            {
                "name": "Ying Zhi",
                "org": "School of Science, Xi'an Jiao Tong University, Xi'an, 710049, PR China"
            },
            {
                "name": "Lingjie Meng",
                "org": "School of Science, Xi'an Jiao Tong University, Xi'an, 710049, PR China"
            },
            {
                "name": "Xichang Bao",
                "org": "Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, PR China"
            },
            {
                "name": "Renqiang Yang",
                "org": "Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, PR China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan, 411105, PR China"
            }
        ],
        "venue": "Organic Electronics",
        "year": 2016
    },
    "ZITBWfRn": {
        "id": "ZITBWfRn",
        "title": "Combining Benzotriazole and Benzodithiophene Host Units in Host\u2013Guest Polymers for Efficient and Stable Near\u2010Infrared Emission from Light\u2010Emitting Electrochemical Cells",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Wenjing Xiong",
                "org": ""
            },
            {
                "name": "Shi Tang",
                "org": "The Organic Photonics and Electronics GroupUme\u00e5 University SE\u201090187 Umea Sweden"
            },
            {
                "name": "Petri Murto",
                "org": "Department of Chemistry and Chemical EngineeringChalmers University of Technology SE\u2010412 96 G\u00f6teborg Sweden"
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            },
            {
                "name": "Ludvig Edman",
                "org": "The Organic Photonics and Electronics GroupUme\u00e5 University SE\u201090187 Umea Sweden"
            },
            {
                "name": "Ergang Wang",
                "org": "Department of Chemistry and Chemical EngineeringChalmers University of Technology SE\u2010412 96 G\u00f6teborg Sweden"
            }
        ],
        "venue": "Advanced Optical Materials",
        "year": 2019
    },
    "6Nj7AOSv": {
        "id": "6Nj7AOSv",
        "title": "Novel wide band-gap polymer utilizing fused hetero-aromatic unit for efficient polymer solar cells and field-effect transistors",
        "abstract": "",
        "keywords": [
            "polymer solar cells"
        ],
        "authors": [
            {
                "name": "dongfeng dang",
                "org": ""
            },
            {
                "name": "pei zhou",
                "org": ""
            },
            {
                "name": "juan zhong",
                "org": ""
            },
            {
                "name": "jiang fan",
                "org": ""
            },
            {
                "name": "zongrui wang",
                "org": ""
            },
            {
                "name": "yafei wang",
                "org": ""
            },
            {
                "name": "yong pei",
                "org": ""
            },
            {
                "name": "xichang bao",
                "org": ""
            },
            {
                "name": "renqiang yang",
                "org": ""
            },
            {
                "name": "wenping hu",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Polymer",
        "year": 2014
    },
    "vAKTBQ3l": {
        "id": "vAKTBQ3l",
        "title": "SET promotes H2Ak9 acetylation by suppressing HDAC1 in trichloroethylene-induced hepatic cytotoxicity.",
        "abstract": "Trichloroethylene (TCE) was widely used as an industrial solvent which could cause severe liver damage. The histone chaperone SET have been identified as an important mediator of TCE-induced hepatic cytotoxicity in our previous study; however, the underlying regulatory mechanisms remain poorly understood. In this study, we found a total of 136 histone acetylation sites involved in TCE-induced hepatic cytotoxicity with the technique of Triton-acid-urea polyacrylamide gel electrophoresis (TAU-PAGE) coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Importantly, 17 histone acetylation sites were revealed to be mediated by SET in TCE-induced cytotoxicity. The acetylation of histone H2AK9 (H2AK9ac) was further validated by Western-blot analysis. The data showed that TCE treatment increased the acetylation of H2AK9 in hepatic L-02 cell and decreased the one in SET-knockdown L-02 cells. Besides, levels of the histone deacetylases (HDACs, including HDAC1, HDAC2, and HDAC3) was also analyzed. Interestingly, the level of HDAC1 was aberrantly suppressed in TCE-treated L-02 cells while enhanced in SET-knockdown L-02 cells. To further explore the potential role of HDAC1 in SET-mediated hepatic cytotoxicity of TCE, we employed RNA interference (RNAi) to knockdown HDAC1 in both wide type L-02 and SET-knockdown cells. The results showed that the siRNA inhibition of HDAC1 increased the acetylation of H2AK9. Taken together, our data suggested that SET promoted the acetylation of H2AK9 via suppressing the level of HDAC1, which was involved in SET-mediated hepatic cytotoxicity of TCE.",
        "keywords": [
            "Histone acetylation",
            "Histone deacetylases",
            "SET",
            "Trichloroethylene"
        ],
        "authors": [
            {
                "name": "Weixue Lu",
                "org": "School of Chemistry, Xiangtan University, Yuhu District, Xiangtan, 411105, Hunan, China; Institute of Toxicology, Shenzhen Center for Disease Control and Prevention, No 8 Longyuan Road, Nanshan District, Shenzhen, 518055, Guangdong, China."
            },
            {
                "name": "Zhihong Chen",
                "org": "Institute of Toxicology, Shenzhen Center for Disease Control and Prevention, No 8 Longyuan Road, Nanshan District, Shenzhen, 518055, Guangdong, China; School of Public Health, Southern Medical University, Tonghe District, Guangzhou, 510515, China."
            },
            {
                "name": "Xiaohu Ren",
                "org": "Institute of Toxicology, Shenzhen Center for Disease Control and Prevention, No 8 Longyuan Road, Nanshan District, Shenzhen, 518055, Guangdong, China."
            },
            {
                "name": "Wei Liu",
                "org": "Institute of Toxicology, Shenzhen Center for Disease Control and Prevention, No 8 Longyuan Road, Nanshan District, Shenzhen, 518055, Guangdong, China."
            },
            {
                "name": "Rongxia Deng",
                "org": "Institute of Toxicology, Shenzhen Center for Disease Control and Prevention, No 8 Longyuan Road, Nanshan District, Shenzhen, 518055, Guangdong, China."
            },
            {
                "name": "Jianhui Yuan",
                "org": "Institute of Toxicology, Shenzhen Center for Disease Control and Prevention, No 8 Longyuan Road, Nanshan District, Shenzhen, 518055, Guangdong, China."
            },
            {
                "name": "Xinfeng Huang",
                "org": "Institute of Toxicology, Shenzhen Center for Disease Control and Prevention, No 8 Longyuan Road, Nanshan District, Shenzhen, 518055, Guangdong, China."
            },
            {
                "name": "Weiguo Zhu",
                "org": "School of Chemistry, Xiangtan University, Yuhu District, Xiangtan, 411105, Hunan, China; School of Materials Science and Engineering, Jiangsu Collaboration Innovation Center of Photovoltaic Science and Engineering, Changzhou University, Wujin District, Changzhou 213164, China. Electronic address: zhuwg18@126.com."
            },
            {
                "name": "Jianjun Liu",
                "org": "Institute of Toxicology, Shenzhen Center for Disease Control and Prevention, No 8 Longyuan Road, Nanshan District, Shenzhen, 518055, Guangdong, China. Electronic address: junii8@126.com."
            }
        ],
        "venue": "Environmental toxicology and pharmacology",
        "year": 2018
    },
    "QPVsCIsV": {
        "id": "QPVsCIsV",
        "title": "High performance of inverted polymer solar cells with cobalt oxide as hole-transporting layer",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xiangdong wang",
                "org": ""
            },
            {
                "name": "qing peng",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            },
            {
                "name": "gangtie lei",
                "org": ""
            }
        ],
        "venue": "Semiconductor Science and Technology",
        "year": 2015
    },
    "wyxqcfrS": {
        "id": "wyxqcfrS",
        "title": "Fluorination as an effective tool to increase the photovoltaic performance of indacenodithiophene-alt-quinoxaline based wide-bandgap copolymers",
        "abstract": "Abstract   To investigate the effect of the fluoride phenyl side-chains into quinoxaline (PQx) unit on the photovoltaic performances of polymers, we demonstrated the synthesis and characterization of two novel wide-bandgap (WBG) copolymers, PIDT-DTPQx and PIDT-DTFPQx, in which indacenodithiophene (IDT), 2,3-diphenylquinoxaline (PQx) (and/or 2,3-bis(4-fluorophenyl)quinoxaline (FPQx)) and thiophene (T) were used as the donor (D) unit, acceptor (A) unit and \u03c0-bridge, respectively. Compared to the non-fluorine substituted PIDT-DTPQx, fluorine substituted PIDT-DTFPQx presents a deep HOMO energy level and a high hole mobility. Obviously, improved the  V  oc ,  J  sc , and  FF  simultaneously, giving rise to overall efficiencies in the PIDT-DTFPQx/PC 71 BM-based PSCs. A highest PCE of 5.78% was obtained with a  V  oc  of 0.86\u00a0V,  J  sc  of 10.84\u00a0mA\u00a0cm \u22122  and  FF  of 61.7% in the PIDT-DTFPQx/PC 71 BM-based PSCs, while PIDT-DTPQx based devices also demonstrated a PCE of 5.11%, under the illumination of AM 1.5G (100\u00a0mW\u00a0cm \u22122 ). Note that these PCE values were achieved for PSCs without any extra treatments. Furthermore, these optimal devices have a film thickness of about 175\u00a0nm for the polymer/PC 71 BM-based active layers. The results provide that introduction of the fluorine atom into quinoxaline unit by side-chain engineering is one of the effective strategies to construct the promising polymer donor materials for future application of large-area polymer solar cells.",
        "keywords": "",
        "authors": [
            {
                "name": "Qunping Fan",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Yu Liu",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Huanxiang Jiang",
                "org": "Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China"
            },
            {
                "name": "Wenyan Su",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Linrui Duan",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Yuanyuan Li",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Jiyong Deng",
                "org": "School of Chemistry and Chemical Engineering of Hunan Institute of Engineering, Xiangtan 411105, China"
            },
            {
                "name": "Renqiang Yang",
                "org": "Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            }
        ],
        "venue": "Organic Electronics",
        "year": 2016
    },
    "mvU0cVvG": {
        "id": "mvU0cVvG",
        "title": "A wide-bandgap polymer based on alkylthio-naphthyl- substituted benzo[1,2-b:4,5-b\u2032]dithiophene units for efficient fullerene-based and fullerene-free polymer solar cells",
        "abstract": "Abstract   A wide-bandgap polymer PBDTNS-TPD based on alkylthio-naphthyl-substituted benzo[1,2-b:4,5-b\u2032]dithiophene (BDT) units was designed and synthesized. Benefiting from the prolonged conjugation of the conjugated side groups on BDT units, the PBDTNS-TPD exhibited better light-harvesting properties and charge transport properties than that of alkylthio-phenyl-substituted counterpart PBDTBS-TPD. The PBDTNS-TPD:PC 71 BM solar cell devices yield a power conversion efficiency (PCE) of 9.09%, which exhibits an increase of 29% in comparison with that of PBDTBS-TPD-based PSCs (PCE 7.02%). Moreover, the PBDTNS-TPD:ITIC based PSCs also showed a higher PCE of 8.19% compared to the PBDTBS-TPD:ITIC based PSCs (PCE 5.93%). This work demonstrates that the replacement of the alkylthio-phenyl moiety with alkylthio-naphthyl unit on BDT is a useful method to design high-performance wide-bandgap polymers for fullerene-based and fullerene-free PSCs.",
        "keywords": "",
        "authors": [
            {
                "name": "Jun Zhang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Jun Zhang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Gongyue Huang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Gongyue Huang",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Huanxiang Jiang",
                "org": "Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China"
            },
            {
                "name": "Baoqi Wu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Gangtie Lei",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            },
            {
                "name": "Weichao Chen",
                "org": "Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China"
            },
            {
                "name": "Renqiang Yang",
                "org": "Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, China"
            }
        ],
        "venue": "Polymer",
        "year": 2018
    },
    "cVDbhFqS": {
        "id": "cVDbhFqS",
        "title": "Enhanced Photovoltaic Performance of Indacenodithiophene\u2010Quinoxaline Copolymers by Side\u2010Chain Modulation",
        "abstract": "",
        "keywords": [
            "energy conversion",
            "polymer solar cells"
        ],
        "authors": [
            {
                "name": "dongfeng dang",
                "org": "xiangtan university"
            },
            {
                "name": "weichao chen",
                "org": "chinese academy of sciences"
            },
            {
                "name": "scott himmelberger",
                "org": "stanford university"
            },
            {
                "name": "qiang tao",
                "org": "xiangtan university"
            },
            {
                "name": "angelica lundin",
                "org": ""
            },
            {
                "name": "renqiang yang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "weiguo zhu",
                "org": "xiangtan university"
            },
            {
                "name": "alberto salleo",
                "org": "stanford university"
            },
            {
                "name": "christian muller",
                "org": ""
            },
            {
                "name": "ergang wang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "98tsCtr6": {
        "id": "98tsCtr6",
        "title": "An efficient method to achieve a balanced open circuit voltage and short circuit current density in polymer solar cells",
        "abstract": "Utilizing indacenodithiophene (D) and quinoxaline (A) building blocks, novel D\u2013A\u2013\u03c0\u2013A type regular terpolymers of PIDT-DTQ-TT were designed with a conjugated \u03c0 spacer of thieno[3,2-b]thiophene unit in the polymer backbone. In contrast to PIDT-DTQ with the thiophene unit as the spacer, PIDT-DTQ-TT displayed a much broader absorption with suitable HOMO energy levels and high charge carrier mobility. Also an enhanced Jsc of 12.43 mA cm\u22122 and a Voc of 0.83 V comparable to that of PIDT-DTQ-based devices were observed in PIDT-DTQ-TT-based solar cells, indicating that the balance between Jsc and Voc in devices can be achieved when the spacer in the polymer backbone was altered individually in D\u2013A\u2013\u03c0\u2013A type regular terpolymers. Finally, a maximum power conversion efficiency value of 6.63% was achieved without any post-treatment in solar cells. Our results here demonstrate that tuning the conjugated spacers in D\u2013A\u2013\u03c0\u2013A type regular terpolymers individually could be an efficient method to balance the trade-off between Jsc and Voc, leading to an enhanced photovoltaic performance in solar cells.",
        "keywords": "",
        "authors": [
            {
                "name": "Dongfeng Dang",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University,Xiangtan 411105,P. R. China"
            },
            {
                "name": "Pei Zhou",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University,Xiangtan 411105,P. R. China"
            },
            {
                "name": "Linrui Duan",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University,Xiangtan 411105,P. R. China"
            },
            {
                "name": "Linrui Duan",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University,Xiangtan 411105,P. R. China"
            },
            {
                "name": "Xichang Bao",
                "org": "Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences,Qingdao 266101,P. R. China"
            },
            {
                "name": "Renqiang Yang",
                "org": "Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences,Qingdao 266101,P. R. China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University,Xiangtan 411105,P. R. China"
            }
        ],
        "venue": "Journal of Materials Chemistry",
        "year": 2016
    },
    "kfTYpC0l": {
        "id": "kfTYpC0l",
        "title": "Novel D(A-Ar)2 type small molecules with oligothiophene, diketopyrrolopyrrole and benzo[4,5]thieno [2,3-b]indole units: investigation on relationship between structure and property for organic solar cells",
        "abstract": "Abstract   Two novel D(A-Ar) 2  type small molecules (SMs) of 3T(DPP-BTI) 2  and 4T(DPP-BTI) 2  were synthesized and characterized, which contain diketopyrrolopyrrole (DPP) arms, 6-dodecyl-6 H -benzo[4,5]thieno[2,3- b ]indole (BTI) terminals, and oligomerthiophene donor unit (3T=trithiophene, 4T=tetrathiophene). The relation-ship between structure and property was investigated. Compared with their corresponding parent A-D-A type SMs, both D(A-Ar) 2  type SMs exhibited a significantly increasing circuit current density ( J  sc ) by 1.39\u223c1.59 times and hole mobility (\u03bc h ) by one order of magnitude, as well as a comparable power conversion efficiency (PCE) in their OPV and hole-only devices. The better photovoltaic properties with PCE of 3.02% and  J  sc  of 10.41\u00a0mA cm \u22122  were obtained in the 3T(DPP-BTI) 2  based OPV cells. It indicates that appending the BTI terminal unit into A-D-A-type SMs is beneficial to increasing the  J  sc  and \u03bc h  values of its resulting D(A-Ar) 2  type SMs in their corresponding devices.",
        "keywords": "",
        "authors": [
            {
                "name": "Hongrui Qi",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Youming Zhang",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Qiang Tao",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Jianhua Chen",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Zuojia Li",
                "org": "Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China"
            },
            {
                "name": "Xiaopeng Xu",
                "org": "Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            },
            {
                "name": "Qiang Peng",
                "org": "Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan 411105, China"
            }
        ],
        "venue": "Tetrahedron",
        "year": 2016
    },
    "7mFSOimq": {
        "id": "7mFSOimq",
        "title": "Improving photovoltaic performance of the linear benzothienoindole-terminated molecules by tuning molecular framework and substituted position of terminals",
        "abstract": "Abstract   A novel type of the benzo[4,5]thieno[2,3- b ]indole (BTI)-terminated small molecules (SMs) with a D\u2032(A-D) 2  framework were synthesized and characterized, i.e. BDT(DPP- 9 -BTI) 2 , BDT(DPP- 8 -BTI) 2  and 2T(DPP- 8 -BTI) 2 , in which the central donor (D\u2032) units are benzodithiene (BDT) and dithiophene (2T), the armed acceptor (A) unit is dithienyl-diketopyrrolopyrrole (DPP), and the terminated donor (D) unit is BTI with different substituted position. For comparison, the SMs with a D-A-D framework, DPP-9-2BTI and DPP-8-2BTI, were also synthesized. The photophysical, electro-chemical, thermal, and photovoltaic properties were preliminary investigated. It is found that the molecular framework and the substituted position of BTI have a significant influence on these properties. The D\u2032(A-D) 2  type SMs exhibited better photovoltaic per-formances than the D-A-D type SMs. Furthermore, the SMs suspending 8-sbstituted BTI displayed better photovoltaic performances than those corresponding SMs suspending 9-sbstituted BTI. The highest power conversion efficiency of 4.80% and a maximum short-circuit current density of 11.91\u00a0mA\u00a0cm \u22122  were obtained in the solution-processed BDT(DPP- 8 -BTI) 2 -based solar cells using [6,6]-phenyl-C-71-butyric acid methyl ester as acceptor. It indicates that tuning the molecular framework and substituted position of the BTI terminals is an efficient strategy to improve photovoltaic performances for their small molecules.",
        "keywords": "",
        "authors": [
            {
                "name": "Hongrui Qi",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan, 411105, China"
            },
            {
                "name": "Xiaopeng Xu",
                "org": "Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, China"
            },
            {
                "name": "Qiang Tao",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan, 411105, China"
            },
            {
                "name": "Youming Zhang",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan, 411105, China"
            },
            {
                "name": "Mengbing Zhu",
                "org": "Jiangsu Collaboration Innovation Center of Photovoltaic Science and Engineering, School of Materials Science and Engineering, Changzhou University, Changzhou, 213164, China"
            },
            {
                "name": "Lin Shao",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan, 411105, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Xiangtan University, Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan, 411105, China"
            },
            {
                "name": "Qiang Peng",
                "org": "Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, China"
            },
            {
                "name": "Yunfeng Liao",
                "org": "College of Chemistry & Chemical Engineering, Hunan Institute of Engineering, Xiangtan, 411104, China"
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2017
    },
    "pmMsURJT": {
        "id": "pmMsURJT",
        "title": "High-performance asymmetric small molecular donor materials based on indenothiophene for solution-processed organic solar cells",
        "abstract": "Abstract   Two novel asymmetric organic small molecules of IT(2FBT-T3Cz) 2  and IT(2FBT-TT3Cz) 2  with an indenothiophene (IT) central donor core, fluorinated benzothiadiazole (2FBT) as acceptor and 3-carbazole (Cz) unit as terminal group were designed and synthesized as the donor materials in organic solar cells (OSCs). The thermal, optical absorption, electrochemical property, hole\u2013electron mobility, film morphology were thoroughly studied. Using PC 71 BM as an electron acceptor, without any additive and thermal annealing (TA) treatment, the IT(2FBT-T3Cz) 2 -based cells showed a promising power conversion efficiency (PCE) of 5.81% and the IT(2FBT-TT3Cz) 2 -based cells exhibited a PCE of 4.39%. Our results demonstrate that the IT-based asymmetric small molecules can be developed as a promising class of donor materials for high-performance OSCs.",
        "keywords": "",
        "authors": [
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, Hunan, China"
            },
            {
                "name": "Baoqi Wu",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, Hunan, China"
            },
            {
                "name": "Jun Zhang",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, Hunan, China"
            },
            {
                "name": "Qiang Tao",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, Hunan, China"
            },
            {
                "name": "Wenhong Peng",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, Hunan, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Xiangtan University, Xiangtan 411105, Hunan, China"
            }
        ],
        "venue": "Journal of Energy Chemistry",
        "year": 2018
    },
    "QcyEWoPh": {
        "id": "QcyEWoPh",
        "title": "D(A-A\u2032)2 architecture: An efficient strategy to improve photovoltaic performance of small molecules for solution-processed organic solar cells",
        "abstract": "Abstract   Two novel small molecules (SMs) of BDT(TPD-DPP) 2  and BDTT(TPD-DPP) 2  with a D(A-A\u2032) 2  framework were designed and synthesized, in which the electron-rich benzodithiophene (BDT) and thiophenyl-substituted benzodithiophene (BDTT) are used as a central donor (D) core, as well as the electron-deficient diketopyrrolopyrrole (DPP) and thieno [3,4-c]pyrrole-4,6-dione (TPD) as dual acceptor (A and A\u2032) units, respectively. Their optical, electrochemical, and photovoltaic properties were investigated together with their counterparts, which bearing an accepter-donor-accepter (A-D-A) architecture. Wider and stronger solar photon responses and decreasing the lowest unoccupied orbital (LUMO) levels are observed in the D(A-A\u2032) 2  rather than A-D-A type SMs. The significantly increasing power conversion efficiency of 4.25% with a short-circuit current density of 10.08\u00a0mA\u00a0cm \u22122  were obtained in the BDTT(TPD-DPP) 2  based solar cells. This work demonstrates that using D(A-A\u2032) 2  architecture with dual acceptor units is an effective method to improve photovoltaic performance of SMs for solution-processed organic solar cells.",
        "keywords": "",
        "authors": [
            {
                "name": "Qiang Tao",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Linrui Duan",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Linrui Duan",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Wenjing Xiong",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Gongyue Huang",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Pu Wang",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Hua Tan",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Yafei Wang",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Renqiang Yang",
                "org": "Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, PR China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2016
    },
    "NXwgWrz3": {
        "id": "NXwgWrz3",
        "title": "Two T-Shaped Donor\u2013Acceptor Small Molecules Based on 4,9-Di(thiophen-2-yl)naphtho[2,3-b]thiophene for Solution-Processed Organic Solar Cells",
        "abstract": "Two novel T-shaped \u03c0-conjugated small molecules of DTNT-3DPP and DTNT(DPP-PN)3 with 4,9-di(thiophen-2-yl)naphtho[2,3-b]thiophene (DTNT) as the donor core and diketopyrrolopyrrole (DPP) as acceptor arms, in the latter case incorporating phenanthrene (PN) units, have been designed and synthesized. The effects of the central core and terminal units on the optical, thermal, electrochemical, and photovoltaic properties have been investigated. It was found that DTNT-3DPP and DTNT(DPP-PN)3 exhibit better light-harvesting and charge-transport properties than triphenylamine (TPA)-based star-shaped molecules. DTNT-3DPP and DTNT(DPP-PN)3 were used as donor materials and methyl [6,6]-phenyl-C71-butyrate (PC71BM) as the acceptor for the fabrication of solution-processed bulk heterojunction (BHJ) solar cells. The power conversion efficiencies (PCEs) of solar cells based on DTNT-3DPP and DTNT(DPP-PN)3 are 3.47 and 3.69\u2009%, respectively. These PCEs are higher than those of the corresponding TPA-based solar cells (1.91 and 3.67\u2009%). Our work indicates that the planar DTNT unit can improve the photovoltaic properties of organic small molecules relative to those of the TPA unit.",
        "keywords": "",
        "authors": [
            {
                "name": "Hua Tan",
                "org": "Xiangtan University College of Chemistry Xiangtan P. R. China"
            },
            {
                "name": "Wenhong Peng",
                "org": "Xiangtan University College of Chemistry Xiangtan P. R. China"
            },
            {
                "name": "Hongjian Liu",
                "org": "Xiangtan University College of Chemistry Xiangtan P. R. China"
            },
            {
                "name": "Yuhong Luo",
                "org": "Xiangtan University College of Chemistry Xiangtan P. R. China"
            },
            {
                "name": "Yu Chen",
                "org": "Xiangtan University College of Chemistry Xiangtan P. R. China"
            },
            {
                "name": "Linrui Duan",
                "org": "Xiangtan University College of Chemistry Xiangtan P. R. China"
            },
            {
                "name": "Linrui Duan",
                "org": "Xiangtan University College of Chemistry Xiangtan P. R. China"
            },
            {
                "name": "Junting Yu",
                "org": "Xiangtan University College of Chemistry Xiangtan P. R. China"
            },
            {
                "name": "Youming Zhang",
                "org": "Xiangtan University College of Chemistry Xiangtan P. R. China"
            },
            {
                "name": "Jun Zhang",
                "org": "Xiangtan University College of Chemistry Xiangtan P. R. China"
            },
            {
                "name": "Yafei Wang",
                "org": "Xiangtan University College of Chemistry Xiangtan P. R. China"
            },
            {
                "name": "Renqiang Yang",
                "org": "Chinese Academy of Sciences Qingdao Institute of Bioenergy and Bioprocess Technology Qingdao P. R. China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Xiangtan University College of Chemistry Xiangtan P. R. China"
            }
        ],
        "venue": "European Journal of Organic Chemistry",
        "year": 2016
    },
    "mFwW4NDJ": {
        "id": "mFwW4NDJ",
        "title": "Spirobifluorene-cored wide bandgap non-fullerene small molecular acceptor with 3D structure for organic solar cells",
        "abstract": "Abstract   In this paper, a wide bandgap small molecule (SF(BR) 4 ) based on spirobifluorene (SF) core, which is flanked with 2,1,3-benzothiadiazole and end-capped with 3-ethylrhodanine groups is synthesized and investigated as a non-fullerene acceptor in solution-processed organic solar cells (OSCs). The SF(BR) 4  shows a wide optical bandgap of 2.10\u202feV and great advantages with respect to the low bandgap donor material poly[(5,6-difluoro-2,1,3-benzothiadiazol-4,7-diyl)-alt-(3,3\u2034-di(2-octyldodecyl)2,2\u2032; 5\u2032,2\u2033; 5\u2033,2\u2034-quaterthiophen-5,5\u2034-diyl)] (PffBT4T-2OD), such as well energy-level matching and complementary absorption. Furthermore, the three dimensional (3D) molecular geometry of SF(BR) 4  helps to suppress the strong intermolecular aggregation in PffBT4T-2OD:SF(BR) 4  blend, leading to efficient non-fullerene OSCs. The resultant devices show a power conversion efficiency (PCE) of 6.15%. To our best knowledge, the PCE is among the highest reported to date for 3D non-fullerene acceptors except perylene diimides derivatives.",
        "keywords": "",
        "authors": [
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Xiangtan University, Xiangtan, 411105, China"
            },
            {
                "name": "Yi Long",
                "org": "College of Chemistry, Xiangtan University, Xiangtan, 411105, China"
            },
            {
                "name": "Jun Zhang",
                "org": "College of Chemistry, Xiangtan University, Xiangtan, 411105, China"
            },
            {
                "name": "Jianing Zhu",
                "org": "College of Chemistry, Xiangtan University, Xiangtan, 411105, China"
            },
            {
                "name": "Jia Yang",
                "org": "College of Chemistry, Xiangtan University, Xiangtan, 411105, China"
            },
            {
                "name": "Junting Yu",
                "org": "Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, 411201, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "College of Chemistry, Xiangtan University, Xiangtan, 411105, China"
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2019
    },
    "uO12jnte": {
        "id": "uO12jnte",
        "title": "Efficient chemical structure and device engineering for achieving difluorinated 2,2\u2032-bithiophene-based small molecular organic solar cells with 9.0% efficiency",
        "abstract": "Linear small molecules have been proved to be promising donor materials for high performance small molecular solar cells (SMSCs). In this paper, a series of narrow-band gap, \u03c0-conjugated small molecules (SMs) with a D(A\u2013Ar)2 linear framework, denoted as FBT(PyDPP-T)2, FBT(IID-T)2 and FBT(TDPP-T)2, based on fluorinated 2,2\u2032-bithiophene (FBT) as an electron-donating (D) central core, pyridine-flanked diketopyrrolopyrrole (PyDPP), isoindigo (IID) or thiophene-flanked diketopyrrolopyrrole (TDPP) as electron-accepting (A) units, and 2-octylthiophene (Ar) units as end-capping units, have been designed and synthesized for application as donor materials in solution-processed SM organic solar cells (OSCs). The impacts of different acceptor units and fluorinated central cores on bulk properties, such as the optoelectronic properties, carrier mobility, the HOMO/LUMO energy level, and the morphologies of blend films, as well as optimization on device performance via appropriate solvent vapor annealing (SVA) are systematically investigated. The as-cast devices based on FBT(PyDPP-T)2, FBT(IID-T)2 and FBT(TDPP-T)2 exhibit PCEs of 5.04%, 5.68% and 6.86%, respectively. Encouragingly, after a SVA treatment with carbon disulfide (CS2) for 20 s, an impressively improved power conversion efficiency (PCE) from 6.86% to 9.00% with an increase of 35% was obtained in the FBT(TDPP-T)2/PC71BM (w/w, 1\u2006:\u20061) based cells due to an enhanced short circuit current density (Jsc) of 16.14 mA cm\u22122 and fill factor (FF) of 73.52%, which is among the highest reported for D(A\u2013Ar)2-type SM-based solar cells with a PCE up to 9.0% so far. Our research results reported here clearly demonstrate that highly efficient SM-OSCs can be obtained via rational design of their molecular structure and optimization of the phase-separated morphology through an appropriate solvent-vapor annealing process.",
        "keywords": "",
        "authors": [
            {
                "name": "Min Li",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University,Xiangtan 411105,China"
            },
            {
                "name": "Zhongbin Qiu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University,Xiangtan 411105,China"
            },
            {
                "name": "Guangjun Zhang",
                "org": "Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, State Key Laboratory of Polymer Materials Engineering, Sichuan University,Chengdu 610065,China"
            },
            {
                "name": "Yu Liu",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University,Xiangtan 411105,China"
            },
            {
                "name": "Lin Xiong",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University,Xiangtan 411105,China"
            },
            {
                "name": "Dan Bai",
                "org": "Department of Biochemistry and Molecular Biology, School of Medicine, Xi'an Jiaotong University,Xi'an,China"
            },
            {
                "name": "Mengbing Zhu",
                "org": ""
            },
            {
                "name": "Qiang Peng",
                "org": "Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, State Key Laboratory of Polymer Materials Engineering, Sichuan University,Chengdu 610065,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            }
        ],
        "venue": "Journal of Materials Chemistry",
        "year": 2018
    },
    "ETDpy9WS": {
        "id": "ETDpy9WS",
        "title": "Simple-structured small molecule acceptors constructed by a weakly electron-deficient thiazolothiazole core for high-efficiency non-fullerene organic solar cells",
        "abstract": "Non-fullerene organic solar cells (OSCs) have attracted significant attention recently due to their tremendous advances in power conversion efficiency (PCE). It has been found that most non-fullerenes are small molecule acceptors (SMAs) bearing electron-rich cores of polycyclic arenes. However, these polycyclic arenes have a high synthetic cost. Here, a novel strategy is proposed to construct SMAs using simple and weakly electron-deficient thiazolothiazole (TTz) as the core. Two simple-structured SMAs of TTz1 and TTz2 with an A(\u03c0\u2013A\u2032\u2013A\u2032\u2032)2 framework are designed and synthesized for potential applications in OSCs, in which benzothiadiazole and malononitrile derivatives are employed as a dual electron-accepting (A\u2032\u2013A\u2032\u2032) arm. Their optical, electrochemical and photovoltaic performances are systematically investigated. We find that both TTz1 and TTz2 exhibit decreased LUMO and increased HOMO energy levels in comparison to the prototypical small molecules TT0 and TTz0 bearing a single electron-accepting (A\u2032\u2032) terminal end. Medium optical bandgap of about 1.60 eV and satisfactory energy levels are obtained for both molecules TTz1 and TTz2 with more balanced carrier mobility by introducing a novel TTz core and tuning the A\u2032\u2013A\u2032\u2032 arm. The highest PCE value of 8.77% is recorded in TTz1-based OSCs blended with the common electron-donating material J71, which is the highest efficiency among OSCs using simple-structured SMAs as non-fullerenes to date. This study reveals great potential to construct high-efficiency and simple-structured SMAs using a weakly electron-deficient TTz core instead of an electron-donating polycyclic arene core.",
        "keywords": "",
        "authors": [
            {
                "name": "Wenhong Peng",
                "org": ""
            },
            {
                "name": "Guangjun Zhang",
                "org": "Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, State Key Laboratory of Polymer Materials Engineering, Sichuan University,Chengdu 610064,P. R. China"
            },
            {
                "name": "Lin Shao",
                "org": "Xiangtan University"
            },
            {
                "name": "Chao Ma",
                "org": ""
            },
            {
                "name": "Bin Zhang",
                "org": ""
            },
            {
                "name": "Weijie Chi",
                "org": "Fluorescence Research Group, Singapore University of Technology and Design, 8 Somapah Road,Singapore 487372,Singapore"
            },
            {
                "name": "Qiang Peng",
                "org": "Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, State Key Laboratory of Polymer Materials Engineering, Sichuan University,Chengdu 610064,P. R. China"
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            }
        ],
        "venue": "Journal of Materials Chemistry",
        "year": 2018
    },
    "7EA2OWFO": {
        "id": "7EA2OWFO",
        "title": "An efficient strategy to supervise absorption, mobility, morphology of photovoltaic molecule by inserting a D-A unit",
        "abstract": "Abstract   The absorption, mobility and morphology of molecules in the active layer have a crucial influence on photovoltaic properties of organic solar cells. In this work, we design an A 1 -(D-A) 2 -D-A 1  type oligomer DRCN4FBT on the basis of an A 1 -D-A-D-A 1  type small molecule DRCN2FBT by inserting D-A unit. It is found that oligomer DRCN4FBT exhibits wider absorption spectrum and higher carrier mobility and better morphology than small molecule DRCN2FBT in active layer using fullerene PC 71 BM as acceptor. The absorption and energy level, mobility, morphology of DRCN4FBT in active layer are well supervised by inserting D-A unit in DRCN2FBT. As a result, its power conversion efficiency and short current density are increased by about 20% for the DRCN4FBT/PC 71 BM based organic solar cells in comparison with the DRCN2FBT/PC 71 BM based devices. It indicates that simply increasing D-A unit in small molecules to construct oligomer is an efficient strategy to improve photovoltaic properties.",
        "keywords": "",
        "authors": [
            {
                "name": "Ziqian Gu",
                "org": ""
            },
            {
                "name": "Jiali Guo",
                "org": ""
            },
            {
                "name": "Rulin Hao",
                "org": ""
            },
            {
                "name": "Zixuan Lin",
                "org": ""
            },
            {
                "name": "Yu Qian",
                "org": ""
            },
            {
                "name": "Chao Ma",
                "org": ""
            },
            {
                "name": "Yankai Fan",
                "org": ""
            },
            {
                "name": "Xiaoyuan Deng",
                "org": ""
            },
            {
                "name": "Guangjun Zhang",
                "org": "Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, PR China"
            },
            {
                "name": "Wenhong Peng",
                "org": ""
            },
            {
                "name": "Hao Xia",
                "org": ""
            },
            {
                "name": "Qiang Peng",
                "org": "Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu, 610065, PR China"
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2019
    },
    "9yCiiTrB": {
        "id": "9yCiiTrB",
        "title": "An effective heteroatom-substituted strategy on photovoltaic properties of D(A-Ar)2 small molecules for efficient organic solar cells",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Min Li",
                "org": ""
            },
            {
                "name": "Zuojia Li",
                "org": ""
            },
            {
                "name": "Zhen Yang",
                "org": ""
            },
            {
                "name": "Zuoji Liu",
                "org": ""
            },
            {
                "name": "Kai Zhang",
                "org": ""
            },
            {
                "name": "Liang Yang",
                "org": ""
            },
            {
                "name": "Qiang Peng",
                "org": ""
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            },
            {
                "name": "Yu Liu",
                "org": ""
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2019
    },
    "ev6Blzxg": {
        "id": "ev6Blzxg",
        "title": "Starburst Triphenylamine-Based Donor\u2013Acceptor-Type Small Molecules for Solution-Processed Organic Solar Cells",
        "abstract": "Invited for the cover of this issue are Pascal Scholder, Martina Hafner, Achim Walter Hassel, and Ivo Nischang from the Johannes Kepler University Linz, Austria, and the Jena Center for Soft Matter, Germany. The cover image shows the highly porous hybrid scaffold with attached gold nanoparticles functioning as an efficient \u201cgreen\u201d reactor.",
        "keywords": "",
        "authors": [
            {
                "name": "Hua Tan",
                "org": ""
            },
            {
                "name": "Wenhong Peng",
                "org": ""
            },
            {
                "name": "Manjun Xiao",
                "org": ""
            },
            {
                "name": "Chao Xu",
                "org": ""
            },
            {
                "name": "Kaixuan Nie",
                "org": ""
            },
            {
                "name": "Junting Yu",
                "org": ""
            },
            {
                "name": "Yafei Wang",
                "org": ""
            },
            {
                "name": "Yu Liu",
                "org": ""
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            }
        ],
        "venue": "European Journal of Inorganic Chemistry",
        "year": 2016
    },
    "NIL4zCye": {
        "id": "NIL4zCye",
        "title": "A novel D2-A-D1-A-D2-type donor\u2013acceptor conjugated small molecule based on a benzo[1,2-b:4,5-b\u2032]dithiophene core for solution processed organic photovoltaic cells",
        "abstract": "Abstract   A novel D2-A-D1-A-D2-type donor\u2013acceptor conjugated small molecule (DTPA-Q-BDT-Q-DTPA) with a benzo[1,2- b :4,5- b \u2032]dithiophene (BDT) core and two D2-A arms has been synthesized and employed as electron donor for organic solar cells. Solution-processed organic photovoltaic (OPV) devices were fabricated with a configuration of ITO/PEDOT:PSS/DTPA-Q-BDT-Q-DTPA:[6,6]-phenyl-C 61 -butyric acid methyl ester (PC 61 BM)/LiF/Al. A power conversion efficiency (PCE) of 1.22% with an open-circuit voltage ( V  OC ) of 0.64\u00a0V, a short-circuit current ( J  SC ) of 6.10\u00a0mA\u00a0cm \u22122 , and a fill factor ( FF ) of 31.0% was achieved. The PCE is 2.9 times higher than that in the other devices using D2-A-type small molecule TPA-Q-TPA as donor.",
        "keywords": "",
        "authors": [
            {
                "name": "Junting Yu",
                "org": "Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, PR China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "School of Materials Science & Engineering, Changzhou University, Changzhou 213164, PR China"
            },
            {
                "name": "Hua Tan",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            },
            {
                "name": "Qing Peng",
                "org": "College of Chemistry, Key Lab of Environment-Friendly Chemistry and Application in the Ministry of Education, Xiangtan University, Xiangtan 411105, PR China"
            }
        ],
        "venue": "Chemical Physics Letters",
        "year": 2017
    },
    "RncOicaB": {
        "id": "RncOicaB",
        "title": "Small molecule acceptors with indacenodithiophene\u2013benzodithiophene\u2013indacenodithiophene as donating cores for solution-processed non-fullerene solar cells",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jianing Zhu",
                "org": ""
            },
            {
                "name": "Xiangjun Zheng",
                "org": ""
            },
            {
                "name": "Hua Tan",
                "org": ""
            },
            {
                "name": "Hongyi Tan",
                "org": ""
            },
            {
                "name": "Jia Yang",
                "org": ""
            },
            {
                "name": "Junting Yu",
                "org": ""
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            }
        ],
        "venue": "Chemical Physics Letters",
        "year": 2019
    },
    "IjlKcaen": {
        "id": "IjlKcaen",
        "title": "Starburst Triphenylamine\u2010Based Donor\u2013Acceptor\u2010Type Small Molecules for Solution\u2010Processed Organic Solar Cells",
        "abstract": "",
        "keywords": [
            "conjugation",
            "charge transfer",
            "organic solar cells"
        ],
        "authors": [
            {
                "name": "hua tan",
                "org": "ministry of education"
            },
            {
                "name": "wenhong peng",
                "org": "ministry of education"
            },
            {
                "name": "manjun xiao",
                "org": "ministry of education"
            },
            {
                "name": "chao xu",
                "org": "ministry of education"
            },
            {
                "name": "kaixuan nie",
                "org": "ministry of education"
            },
            {
                "name": "junting yu",
                "org": "ministry of education"
            },
            {
                "name": "yafei wang",
                "org": "ministry of education"
            },
            {
                "name": "yu liu",
                "org": "ministry of education"
            },
            {
                "name": "weiguo zhu",
                "org": "ministry of education"
            }
        ],
        "venue": "European Journal of Organic Chemistry",
        "year": 2015
    },
    "6NR9PppH": {
        "id": "6NR9PppH",
        "title": "Crack reason analysis of urea reactor lining with a round pit",
        "abstract": "A urea reactor of which the lining has a round pit defect under the leak detecting hole was studied through finite element analysis and stress corrosion threshold value calculation.The results showed that the stress concentration caused by the round pit could provide an external condition for stress corrosion.So the stress corrosion crack happened under the simultaneous actions of stress concentration and chloride ions.",
        "keywords": [
            "urea reactor",
            "chloride ion",
            "ANSYS",
            "stress corrosion",
            "lining"
        ],
        "authors": [
            {
                "name": "WU Jun-fei",
                "org": "College of Electromechanical Engineering,Qingdao University of Science and Technology,Qingdao ,China"
            },
            {
                "name": "LIN Mei",
                "org": "College of Electromechanical Engineering,Qingdao University of Science and Technology,Qingdao ,China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": "Shandong Special Equipment Inspection and Research Academy,Jinan ,China"
            },
            {
                "name": "ZHANG Yan-fei",
                "org": "College of Electromechanical Engineering,Qingdao University of Science and Technology,Qingdao ,China"
            }
        ],
        "venue": "Journal of Shandong University(Engineering Science)",
        "year": 2010
    },
    "dGI4I6q3": {
        "id": "dGI4I6q3",
        "title": "Lamb Wave Testing Technique of Backside Defects in 316LMod Stainless Steel Linings of Urea Reactors",
        "abstract": "According to Rayleigh-Lamb equation,the dispersion curves of phase and group velocities of 316LMod stainless steel linings were derived out.The main Lamb wave mode of backside defect was drawn out through 2D FFT of echo signal of the sample with artificial defects,then,the Lamb wave testing parameters were confirmed.Through the defect recognition of the sample,the defect equivalent evaluation was given,and then,the quantitative Lamb wave testing of backside defects was realized.Finally,the method was verified by examples of urea reactors testing.",
        "keywords": [
            "Stainless steel",
            "Backside defect",
            "Lamb wave testing",
            "Dispersion curves"
        ],
        "authors": [
            {
                "name": "WANG Chun-Mao",
                "org": "Shandong Special Equipment Inspection & Research Academy,Jinan ,China"
            },
            {
                "name": "ZHU Wei-Guo",
                "org": "Shandong Special Equipment Inspection & Research Academy,Jinan ,China"
            },
            {
                "name": "YUAN Tao",
                "org": "Shandong Special Equipment Inspection & Research Academy,Jinan ,China"
            },
            {
                "name": "SHEN Xiao-Min",
                "org": "Shandong Special Equipment Inspection & Research Academy,Jinan ,China"
            }
        ],
        "venue": "Nondestructive Testing",
        "year": 2010
    },
    "cvIfA4em": {
        "id": "cvIfA4em",
        "title": "Nondestructive Test of Lamb Waves on Backside Crack in Stainless Steel Linings",
        "abstract": "According to Rayleigh-Lamb equation,the dispersion curves of phase and group velocities of 316LMod stainless steel linings were derived out.The main lamb wave mode of backside defect was drawn out through 2D FFT to echo signal of the sample included artificial defects,then the lamb wave testing parametrs of 8 mm 316LMod stainless steel were confimed.Through the defet recognition to the sample,the defect equivalent evaluation was given,then the quantitative lamb wave testing to backside defects was realized.Finally,the method was verified by examples of urea reactors testing.",
        "keywords": [
            "lamb wave test",
            "backside crack",
            "dispersion curves",
            "stainless steel"
        ],
        "authors": [
            {
                "name": "WANG Chun-mao",
                "org": "Shandong Special Equipment Inspection& Research Academy,Jinan ,China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": "Shandong Special Equipment Inspection& Research Academy,Jinan ,China"
            },
            {
                "name": "YUAN Tao",
                "org": "Shandong Special Equipment Inspection& Research Academy,Jinan ,China"
            },
            {
                "name": "SHEN Xiao-min",
                "org": "Shandong Special Equipment Inspection& Research Academy,Jinan ,China"
            }
        ],
        "venue": "Pressure Vessel Technology",
        "year": 2010
    },
    "HdSICwBE": {
        "id": "HdSICwBE",
        "title": "Acoustic Emission Testing on Multilayer Wrapped High-Pressure Vessels",
        "abstract": "Through experimental investigation and destructive comparision for three multilayer wrapped high- pressure vessels using acoustic emission method,an acoustic emission testing technology of multilayer wrapped pressure vessels was studied and the evaluation criterion of testing results were established.The method was applied to 80 urea reactors and many crack flaws were found.These applications showed that acoustic emission testing technology of multilayer wrapped urea reactors was effective.",
        "keywords": [
            "Testing precedure",
            "Evaluation rule",
            "Acoustic emission testing",
            "Multilayer wrap pressure vessel"
        ],
        "authors": [
            {
                "name": "CAO Huai-Xiang",
                "org": "Shandong Special Equipment Inspection Institute,Jinan ,China"
            },
            {
                "name": "ZHU Wei-Guo",
                "org": "Shandong Special Equipment Inspection Institute,Jinan ,China"
            },
            {
                "name": "SONG Ming-Da",
                "org": "Shandong Special Equipment Inspection Institute,Jinan ,China"
            },
            {
                "name": "YUAN Tao",
                "org": "Shandong Special Equipment Inspection Institute,Jinan ,China"
            },
            {
                "name": "WANG Chun-Mao",
                "org": "Shandong Special Equipment Inspection Institute,Jinan ,China"
            }
        ],
        "venue": "Nondestructive Testing",
        "year": 2008
    },
    "YU3X4cZN": {
        "id": "YU3X4cZN",
        "title": "The Typical Defects of Urea Reactor in Comprehensive Testing",
        "abstract": "The typical defects,such as crack of material pipe,corrosion and leakage of urea reactor in comprehensive testing,were introduced.The position and causes of the defects were analyzed in detail.In order to provide reference,typical photos of the defects were given.",
        "keywords": [
            "Interior testing",
            "Embedding defects",
            "Exterior testing",
            "Urea reactor",
            "Defects"
        ],
        "authors": [
            {
                "name": "WANG Chun-Mao",
                "org": "Shandong Special Equipment Inspection & Research Academy,Jinan ,China"
            },
            {
                "name": "ZHU Wei-Guo",
                "org": "Shandong Special Equipment Inspection & Research Academy,Jinan ,China"
            },
            {
                "name": "YUAN Tao",
                "org": "Shandong Special Equipment Inspection & Research Academy,Jinan ,China"
            },
            {
                "name": "SHEN Xiao-Min",
                "org": "Shandong Special Equipment Inspection & Research Academy,Jinan ,China"
            }
        ],
        "venue": "Nondestructive Testing",
        "year": 2009
    },
    "eKY9x86s": {
        "id": "eKY9x86s",
        "title": "Typical Leakage Type in Synthesis Urea Tower and Counter Measure in Inspection",
        "abstract": "Leakage is one of comparatively serious defects existed in synthesis urea tower.In this article,four common leakages,that are leakage from welding joint,leakage from overlay layer,leakage from exam hole and leakage in base material,as well as the counter measures were summarized which is supplied for reference.",
        "keywords": [
            "synthesis urea tower",
            "leakage",
            "inspection"
        ],
        "authors": [
            {
                "name": "WANG Chun-mao",
                "org": "Shandong Special Equipment Inspection& Research Academy,Jinan ,China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": "Shandong Special Equipment Inspection& Research Academy,Jinan ,China"
            },
            {
                "name": "YUAN Tao",
                "org": "Shandong Special Equipment Inspection& Research Academy,Jinan ,China"
            },
            {
                "name": "SHEN Xiao-min",
                "org": "Shandong Special Equipment Inspection& Research Academy,Jinan ,China"
            }
        ],
        "venue": "Process Equipment & Piping",
        "year": 2011
    },
    "9ztM8sTX": {
        "id": "9ztM8sTX",
        "title": "Applications of TOFD of Ultrasonic Imaging Detection Technology in Pressure Vessels Inspection",
        "abstract": "This paper introduces the TOFD ultrasound imaging detection technology\u2032s basic working principle,and elaborates the requirements of the TOFD ultrasound imaging detection technology in pressure vessel inspection.The TOFD ultrasound imaging detection equipment modification,as well as main parameters setting was studied.The data processing methods was analyzed the application of TOFD ultrasound imaging detection technology in pressure vessels inspection was described,and the merits of Ultrasound imaging TOFD detection technology.",
        "keywords": [
            "ultrasound imaging",
            "TOFD",
            "pressure vessel inspection"
        ],
        "authors": [
            {
                "name": "YUAN Tao",
                "org": "Shandong Provincial Special Equipment Inspection and Research Academy,Jinan ,China"
            },
            {
                "name": "CAO Huai-xiang",
                "org": "Shandong Provincial Special Equipment Inspection and Research Academy,Jinan ,China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": "Shandong Provincial Special Equipment Inspection and Research Academy,Jinan ,China"
            },
            {
                "name": "WANG Chun-mao",
                "org": "Shandong Provincial Special Equipment Inspection and Research Academy,Jinan ,China"
            }
        ],
        "venue": "Pressure Vessel Technology",
        "year": 2008
    },
    "2hTvic5y": {
        "id": "2hTvic5y",
        "title": "Failure Analysis of the Steam Pipeline",
        "abstract": "According to analyses of mechanics performance testing,chemical analyses,metallographic examination and scanning electron microscope analyses,the direct cause of the failuree is corrosion and cracking of the metallurgical structure under stress,which is below the set standard.Finally this paper points out that metallographic examination is a necessary way in periodical inspections of pressure piping.",
        "keywords": [
            "failure",
            "steam pipeline",
            "metallographic examination"
        ],
        "authors": [
            {
                "name": "HAN Wei",
                "org": "Shandong Special Equipment Inspection& Research Academy,Jinan ,China"
            },
            {
                "name": "ZHAO Jing-xing",
                "org": "Shandong Special Equipment Inspection& Research Academy,Jinan ,China"
            },
            {
                "name": "WANG Chun-mao",
                "org": "Shandong Special Equipment Inspection& Research Academy,Jinan ,China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": "Shandong Special Equipment Inspection& Research Academy,Jinan ,China"
            }
        ],
        "venue": "Pipeline Technique and Equipment",
        "year": 2012
    },
    "H5RCwY9Y": {
        "id": "H5RCwY9Y",
        "title": "Application of MMM to evaluate aging effects of welded body",
        "abstract": "In this thesis,the application of metal magnetic memory (MMM) on effect of aging is introduced,though compared the test result of MMM,verified the feasibility of MMM in the evaluation of aging effects.Then,the process is applied,and perfect results are obtained.",
        "keywords": [
            "MMM",
            "Evaluation of Aging Effects",
            "Welded Body"
        ],
        "authors": [
            {
                "name": "YUAN Tao",
                "org": "Shandong Special Equipment Inspection Institute,Jinan ,CHN"
            },
            {
                "name": "ZHU Weiguo",
                "org": "Shandong Special Equipment Inspection Institute,Jinan ,CHN"
            },
            {
                "name": "WANG Chunmao",
                "org": "Shandong Special Equipment Inspection Institute,Jinan ,CHN"
            },
            {
                "name": "CAO Huaixiang",
                "org": "Shandong Special Equipment Inspection Institute,Jinan ,CHN"
            },
            {
                "name": "SHEN Xiaomin",
                "org": "Shandong Special Equipment Inspection Institute,Jinan ,CHN"
            }
        ],
        "venue": "Manufacturing Technology & Machine Tool",
        "year": 2011
    },
    "tyKvrb2d": {
        "id": "tyKvrb2d",
        "title": "Lung-specific expression of human mutant p53-273H is associated with a high frequency of lung adenocarcinoma in transgenic mice.",
        "abstract": "To investigate the tumorigenic potential of mutant p53 when selectively expressed in lung tissue, a transgenic mouse model was developed in which a mutant form of p53 (p53-273H) was placed under the transcriptional control of the lung-specific human surfactant protein C (SP-C) promoter. Two founder mice were identified, and a line of SP-C/p53-273H transgenic mice was established from one of the founders. Human p53-273H protein was detected specifically in lung tissue from transgenic mice. Malignant tumors, which were histologically characterized as adenocarcinomas, were observed in transgenic mice, with the earliest onset documented at 4 months of age. To further evaluate incidence and onset of tumor formation, transgenic mice (n=113) were sacrificed at age intervals ranging from 4-15 months. At 13-15 months of age, transgenic mice were significantly more likely to have lung tumors at necropsy than age-matched non-transgenic littermates (9 out of 39 (23%) versus 2 out of 35 (5.7%), chi(2) test, P=0.036). The SP-C/p53-273H transgenic mice described here thus represent a genetically defined model with which to study the role of p53 mutations in lung tumorigenesis, as well as the potential complementary contributions of other genetic alterations or environmental carcinogens to lung tumor development.",
        "keywords": [
            "ONC",
            " oncogenes",
            " cancer",
            " apoptosis",
            " tumor suppressor genes",
            " tumor viruses",
            " molecular oncology",
            " cell cycle",
            " growth factors",
            " growth factor receptors",
            " growth regulatory genes"
        ],
        "authors": [
            {
                "name": "Wenrui Duan",
                "org": ""
            },
            {
                "name": "Haiming Ding",
                "org": ""
            },
            {
                "name": "Mark A Subler",
                "org": ""
            },
            {
                "name": "Wei-Guo Zhu",
                "org": ""
            },
            {
                "name": "Huiming Zhang",
                "org": ""
            },
            {
                "name": "Gary D Stoner",
                "org": ""
            },
            {
                "name": "Jolene J Windle",
                "org": ""
            },
            {
                "name": "Gregory A Otterson",
                "org": ""
            },
            {
                "name": "Miguel A Villalona-Calero",
                "org": ""
            }
        ],
        "venue": "Oncogene",
        "year": 2002
    },
    "nXnXAxxB": {
        "id": "nXnXAxxB",
        "title": "5-aza-2'-deoxycytidine activates the p53/p21Waf1/Cip1 pathway to inhibit cell proliferation.",
        "abstract": "In addition to its demethylating function, 5-aza-2'-deoxycytidine (5-aza-CdR) also plays an important role in inducing cell cycle arrest, differentiation, and cell death. However, the mechanism by which 5-aza-CdR induces antineoplastic activity is not clear. In this study, we found that 5-aza-CdR at limited concentrations (0.01-5 microm) induces inhibition of cell proliferation as well as increased p53/p21(Waf1/Cip1) expression in A549 cells (wild-type p53) but not in H1299 (p53-null) and H719 cells (p53 mutant). The p53-dependent p21(Waf1/Cip1) expression induced by 5-aza-CdR was not seen in A549 cells transfected with the wild-type human papilloma virus type-16 E6 gene that induces p53 degradation. Furthermore, deletion analysis and site-directed mutagenesis of the p21 promoter reveals that 5-aza-CdR induces p21(Waf1/Cip1) expression through two p53 binding sites in the p21 promoter. Finally, 5-aza-CdR-induced p21(Waf1/Cip1) expression was dependent on DNA damage but not on DNA demethylation as demonstrated by comet assay and bisulfite sequencing, respectively. Our data provide useful clues for judging the therapeutic efficacy of 5-aza-CdR in the treatment of human cancer cells.",
        "keywords": [
            "wild type",
            "cell death",
            "dna damage",
            "cell cycle arrest",
            "binding site",
            "cell proliferation"
        ],
        "authors": [
            {
                "name": "Wei-Guo Zhu",
                "org": ""
            },
            {
                "name": "Theresa Hileman",
                "org": ""
            },
            {
                "name": "Yang Ke",
                "org": ""
            },
            {
                "name": "Peichang Wang",
                "org": ""
            },
            {
                "name": "Shaoli Lu",
                "org": ""
            },
            {
                "name": "Wenrui Duan",
                "org": ""
            },
            {
                "name": "Zunyan Dai",
                "org": ""
            },
            {
                "name": "Tanjun Tong",
                "org": ""
            },
            {
                "name": "Miguel A Villalona-Calero",
                "org": ""
            },
            {
                "name": "Christoph Plass",
                "org": ""
            },
            {
                "name": "Gregory A Otterson",
                "org": ""
            }
        ],
        "venue": "The Journal of biological chemistry",
        "year": 2004
    },
    "CRFGBtw9": {
        "id": "CRFGBtw9",
        "title": "SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair",
        "abstract": "The activation of ataxia-telangiectasia mutated (ATM) upon DNA damage involves a cascade of reactions, including acetylation by TIP60 and autophosphorylation. However, how ATM is progressively deactivated after completing DNA damage repair remains obscure. Here, we report that sirtuin 7 (SIRT7)\u2013mediated deacetylation is essential for dephosphorylation and deactivation of ATM. We show that SIRT7, a class III histone deacetylase, interacts with and deacetylates ATM in vitro and in vivo. In response to DNA damage, SIRT7 is mobilized onto chromatin and deacetylates ATM during the late stages of DNA damage response, when ATM is being gradually deactivated. Deacetylation of ATM by SIRT7 is prerequisite for its dephosphorylation by its phosphatase WIP1. Consequently, depletion of SIRT7 or acetylation-mimic mutation of ATM induces persistent ATM phosphorylation and activation, thus leading to impaired DNA damage repair. Together, our findings reveal a previously unidentified role of SIRT7 in regulating ATM activity and DNA damage repair. Copyright \u00a9 2019 The Authors.",
        "keywords": [],
        "authors": [
            {
                "name": "Ming Tang",
                "org": "Guangdong Key Laboratory of Genome Instability and Human Disease, Shenzhen University Carson Cancer Center, Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine, Shenzhen, 518060, China, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China, State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200032, China"
            },
            {
                "name": "Zhiming Li",
                "org": "Guangdong Key Laboratory of Genome Instability and Human Disease, Shenzhen University Carson Cancer Center, Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine, Shenzhen, 518060, China, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China"
            },
            {
                "name": "Chaohua Zhang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China"
            },
            {
                "name": "Xiaopeng Lu",
                "org": "Guangdong Key Laboratory of Genome Instability and Human Disease, Shenzhen University Carson Cancer Center, Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine, Shenzhen, 518060, China"
            },
            {
                "name": "Bo Tu",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China"
            },
            {
                "name": "Ziyang Cao",
                "org": "Guangdong Key Laboratory of Genome Instability and Human Disease, Shenzhen University Carson Cancer Center, Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine, Shenzhen, 518060, China, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China"
            },
            {
                "name": "Yinglu Li",
                "org": "Guangdong Key Laboratory of Genome Instability and Human Disease, Shenzhen University Carson Cancer Center, Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine, Shenzhen, 518060, China, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China"
            },
            {
                "name": "Yongcan Chen",
                "org": "Guangdong Key Laboratory of Genome Instability and Human Disease, Shenzhen University Carson Cancer Center, Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine, Shenzhen, 518060, China, Peking University-Tsinghua University Center for Life Sciences, Beijing, 100871, China"
            },
            {
                "name": "Lu Jiang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China"
            },
            {
                "name": "Hui Wang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China"
            },
            {
                "name": "Lina Wang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China"
            },
            {
                "name": "Jiadong Wang",
                "org": "Institute of Systems Biomedicine, Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, Beijing, 100191, China"
            },
            {
                "name": "Baohua Liu",
                "org": "Guangdong Key Laboratory of Genome Instability and Human Disease, Shenzhen University Carson Cancer Center, Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine, Shenzhen, 518060, China"
            },
            {
                "name": "Xingzhi Xu",
                "org": "Guangdong Key Laboratory of Genome Instability and Human Disease, Shenzhen University Carson Cancer Center, Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine, Shenzhen, 518060, China"
            },
            {
                "name": "Haiying Wang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China"
            },
            {
                "name": "Wei-Guo Zhu",
                "org": "Guangdong Key Laboratory of Genome Instability and Human Disease, Shenzhen University Carson Cancer Center, Department of Biochemistry and Molecular Biology, Shenzhen University School of Medicine, Shenzhen, 518060, China, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China"
            }
        ],
        "venue": "Science Advances",
        "year": 2019
    },
    "9hfEf6l9": {
        "id": "9hfEf6l9",
        "title": "Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses.",
        "abstract": "The tumour suppressor ARF is specifically required for p53 activation under oncogenic stress. Recent studies showed that p53 activation mediated by ARF, but not that induced by DNA damage, acts as a major protection against tumorigenesis in vivo under certain biological settings, suggesting that the ARF-p53 axis has more fundamental functions in tumour suppression than originally thought. Because ARF is a very stable protein in most human cell lines, it has been widely assumed that ARF induction is mediated mainly at the transcriptional level and that activation of the ARF-p53 pathway by oncogenes is a much slower and largely irreversible process by comparison with p53 activation after DNA damage. Here we report that ARF is very unstable in normal human cells but that its degradation is inhibited in cancerous cells. Through biochemical purification, we identified a specific ubiquitin ligase for ARF and named it ULF. ULF interacts with ARF both in vitro and in vivo and promotes the lysine-independent ubiquitylation and degradation of ARF. ULF knockdown stabilizes ARF in normal human cells, triggering ARF-dependent, p53-mediated growth arrest. Moreover, nucleophosmin (NPM) and c-Myc, both of which are commonly overexpressed in cancer cells, are capable of abrogating ULF-mediated ARF ubiquitylation through distinct mechanisms, and thereby promote ARF stabilization in cancer cells. These findings reveal the dynamic feature of the ARF-p53 pathway and suggest that transcription-independent mechanisms are critically involved in ARF regulation during responses to oncogenic stress.",
        "keywords": [
            "Cancer",
            " Biochemistry",
            " Molecular biology",
            " Cell biology"
        ],
        "authors": [
            {
                "name": "Delin Chen",
                "org": ""
            },
            {
                "name": "Jing Shan",
                "org": ""
            },
            {
                "name": "Wei-Guo Zhu",
                "org": "american society for biochemistry and molecular biology"
            },
            {
                "name": "Jun Qin",
                "org": "baylor college of medicine"
            },
            {
                "name": "Wei Gu",
                "org": ""
            }
        ],
        "venue": "Nature",
        "year": 2010
    },
    "juRkdX95": {
        "id": "juRkdX95",
        "title": "Advances in effector protein of histone methylation]",
        "abstract": "As a significant epigenetic regulation mechanism, histone methylation plays an important role in many biological processes. In cells, there are various histone methyltransferases and histone demethylases working cooperatively to regulate the histone methylation state. Upon histone modification, effector proteins recognize modification sites specifically, and affect gene transcriptional process. This review mainly focuses on recent advances in histone methylation effector protein's function mechanism.",
        "keywords": [
            "epigenetics",
            "effector protein of methylated histone",
            "histone modification",
            "gene transcription regulation"
        ],
        "authors": [
            {
                "name": "Bo-Yan Song",
                "org": " Department of Biochemistry and Molecular Biology,Health Science Center,Peking University,Beijing ,China"
            },
            {
                "name": "Wei-Guo Zhu",
                "org": " Department of Biochemistry and Molecular Biology,Health Science Center,Peking University,Beijing ,China"
            }
        ],
        "venue": "Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji",
        "year": 2011
    },
    "uUbJKk5g": {
        "id": "uUbJKk5g",
        "title": "Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter.",
        "abstract": "Histone deacetylase inhibitor (HDACi) has been shown to demethylate the mammalian genome, which further strengthens the concept that DNA methylation and histone modifications interact in regulation of gene expression. Here, we report that an HDAC inhibitor, depsipeptide, exhibited significant demethylating activity on the promoters of several genes, including p16, SALL3, and GATA4 in human lung cancer cell lines H719 and H23, colon cancer cell line HT-29, and pancreatic cancer cell line PANC1. Although expression of DNA methyltransferase 1 (DNMT1) was not affected by depsipeptide, a decrease in binding of DNMT1 to the promoter of these genes played a dominant role in depsipeptide-induced demethylation and reactivation. Depsipeptide also suppressed expression of histone methyltransferases G9A and SUV39H1, which in turn resulted in a decrease of di- and trimethylated H3K9 around these genes' promoter. Furthermore, both loading of heterochromatin-associated protein 1 (HP1alpha and HP1beta) to methylated H3K9 and binding of DNMT1 to these genes' promoter were significantly reduced in depsipeptide-treated cells. Similar DNA demethylation was induced by another HDAC inhibitor, apicidin, but not by trichostatin A. Our data describe a novel mechanism of HDACi-mediated DNA demethylation via suppression of histone methyltransferases and reduced recruitment of HP1 and DNMT1 to the genes' promoter.",
        "keywords": [
            "cpg island",
            "gene regulation",
            "genetics",
            "chromatin structure",
            "regulation of gene expression",
            "cell line",
            "histone methylation",
            "histone modification",
            "colon cancer",
            "dna methylation",
            "gene expression"
        ],
        "authors": [
            {
                "name": "Li-Peng Wu",
                "org": ""
            },
            {
                "name": "Xi Wang",
                "org": ""
            },
            {
                "name": "Lian Li",
                "org": ""
            },
            {
                "name": "Ying Zhao",
                "org": ""
            },
            {
                "name": "Shaoli Lu",
                "org": ""
            },
            {
                "name": "Yu Yu",
                "org": ""
            },
            {
                "name": "Wen Zhou",
                "org": ""
            },
            {
                "name": "Xiangyu Liu",
                "org": ""
            },
            {
                "name": "Jing Yang",
                "org": ""
            },
            {
                "name": "Zhixin Zheng",
                "org": ""
            },
            {
                "name": "Hui Zhang",
                "org": ""
            },
            {
                "name": "Jingnan Feng",
                "org": ""
            },
            {
                "name": "Yang Yang",
                "org": ""
            },
            {
                "name": "Haiying Wang",
                "org": ""
            },
            {
                "name": "Wei-Guo Zhu",
                "org": ""
            }
        ],
        "venue": "Molecular and cellular biology",
        "year": 2008
    },
    "jlUivM2u": {
        "id": "jlUivM2u",
        "title": "An ATR signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21WAF1/cip1 in response to 5-AZA-2'-deoxycytidine treatment",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "haiying wang",
                "org": ""
            },
            {
                "name": "ying zhao",
                "org": ""
            },
            {
                "name": "lian li",
                "org": ""
            },
            {
                "name": "micheal a mcnutt",
                "org": ""
            },
            {
                "name": "lipeng wu",
                "org": ""
            },
            {
                "name": "shaoli lu",
                "org": ""
            },
            {
                "name": "yu yu",
                "org": ""
            },
            {
                "name": "wen zhou",
                "org": ""
            },
            {
                "name": "jingnan feng",
                "org": ""
            },
            {
                "name": "guolin chai",
                "org": ""
            },
            {
                "name": "yang yang",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Journal of Biological Chemistry",
        "year": 2007
    },
    "8MHzTpGt": {
        "id": "8MHzTpGt",
        "title": "Global methylation profiling of lung cancer identifies novel methylated genes.",
        "abstract": "Epigenetic changes, including DNA methylation, are a common finding in cancer. In lung cancers methylation of cytosine residues may affect tumor initiation and progression in several ways, including the silencing of tumor suppressor genes through promoter methylation and by providing the targets for adduct formation of polycyclic aromatic hydrocarbons present in combustion products of cigarette smoke. Although the importance of aberrant DNA methylation is well established, the extent of DNA methylation in lung cancers has never been determined. Restriction landmark genomic scanning (RLGS) is a highly reproducible two-dimensional gel electrophoresis that allows the determination of the methylation status of up to 2000 promoter sequences in a single gel. We selected 1184 CpG islands for RLGS analysis and determined their methylation status in 16 primary non-small cell lung cancers. Some tumors did not show methylation whereas others showed up to 5.3% methylation in all CpG islands of the profile. Cloning of 21 methylated loci identified 11 genes and 6 ESTs. We demonstrate that methylation is part of the silencing process of BMP3B in primary tumors and lung cancer cell lines.",
        "keywords": [
            "dna methylation",
            "epigenetic.",
            "genome scanning",
            "rlgs",
            "small cell lung cancer",
            "non",
            "gene expression profiling",
            "epigenetic",
            "restriction landmark genomic scanning",
            "cpg islands",
            "cpg island",
            "gene silencing",
            "two dimensional gel electrophoresis",
            "down regulation",
            "cell line"
        ],
        "authors": [
            {
                "name": "Z Dai",
                "org": ""
            },
            {
                "name": "R R Lakshmanan",
                "org": ""
            },
            {
                "name": "W G Zhu",
                "org": ""
            },
            {
                "name": "D J Smiraglia",
                "org": ""
            },
            {
                "name": "L J Rush",
                "org": ""
            },
            {
                "name": "M C Fr\u00fchwald",
                "org": ""
            },
            {
                "name": "R M Brena",
                "org": ""
            },
            {
                "name": "B Li",
                "org": ""
            },
            {
                "name": "F A Wright",
                "org": ""
            },
            {
                "name": "P Ross",
                "org": ""
            },
            {
                "name": "G A Otterson",
                "org": ""
            },
            {
                "name": "C Plass",
                "org": ""
            }
        ],
        "venue": "Neoplasia (New York, N.Y.)",
        "year": 2001
    },
    "gzaD1jOo": {
        "id": "gzaD1jOo",
        "title": "An ATM- and Rad3-related (ATR) Signaling Pathway and a Phosphorylation-Acetylation Cascade Are Involved",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "haiying wang",
                "org": ""
            },
            {
                "name": "ying zhao",
                "org": ""
            },
            {
                "name": "l li",
                "org": ""
            },
            {
                "name": "michael a mcnutt",
                "org": ""
            },
            {
                "name": "lipeng wu",
                "org": ""
            },
            {
                "name": "shaoli lu",
                "org": ""
            },
            {
                "name": "wen zhou",
                "org": ""
            },
            {
                "name": "jingnan feng",
                "org": ""
            },
            {
                "name": "guolin chai",
                "org": ""
            },
            {
                "name": "yang yang",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2008
    },
    "Ac064Wju": {
        "id": "Ac064Wju",
        "title": "XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells.",
        "abstract": "Autophagy is activated to maintain cellular energy homeostasis in response to nutrient starvation. However, autophagy is not persistently activated, which is poorly understood at a mechanistic level. Here, we report that turnover of FoxO1 is involved in the dynamic autophagic process caused by glutamine starvation. X-box-binding protein-1u (XBP-1u) has a critical role in FoxO1 degradation by recruiting FoxO1 to the 20S proteasome. In addition, the phosphorylation of XBP-1u by extracellular regulated protein kinases1/2 (ERK1/2) on Ser61 and Ser176 was found to be critical for the increased interaction between XBP-1u and FoxO1 upon glutamine starvation. Furthermore, knockdown of XBP-1u caused the sustained level of FoxO1 and the persistent activation of autophagy, leading to a significant decrease in cell viability. Finally, the inverse correlation between XBP-1u and FoxO1 expression agrees well with the expression profiles observed in many human cancer tissues. Thus, our findings link the dynamic process of autophagy to XBP-1u-induced FoxO1 degradation.",
        "keywords": [
            "foxo1",
            "erk",
            "xbp-1u",
            "cancer",
            "autophagy",
            "CR",
            " cancer",
            " immunology",
            " neurodegeneration",
            " apoptosis",
            " cell death",
            " cell growth",
            " differentiation"
        ],
        "authors": [
            {
                "name": "Ying Zhao",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Xue Li",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Mu-Yan Cai",
                "org": "Sun Yat-Sen University Cancer Center(State Key Laboratory of Oncology in South China,State Key Laboratory of Oncology in Southern China,Sun Yat-sen University Cancer Center,Sun Yat-Sen University Cancer Center),Guangzhou,China"
            },
            {
                "name": "Ke Ma",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Jing Yang",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Jingyi Zhou",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Wan Fu",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Fu-Zheng Wei",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Lina Wang",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Dan Xie",
                "org": "Sun Yat-Sen University Cancer Center(State Key Laboratory of Oncology in South China,State Key Laboratory of Oncology in Southern China,Sun Yat-sen University Cancer Center,Sun Yat-Sen University Cancer Center),Guangzhou,China"
            },
            {
                "name": "Wei-Guo Zhu",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            }
        ],
        "venue": "Cell research",
        "year": 2013
    },
    "TbiJtl1Y": {
        "id": "TbiJtl1Y",
        "title": "The axis of MAPK1/3-XBP1u-FOXO1 controls autophagic dynamics in cancer cells.",
        "abstract": "Earlier studies have shown that macroautophagy is not a constitutively activated process, however, the mechanism of activation is not fully understood. Here, we report that autophagy is a dynamic process in cancer cells in response to glucose starvation. In addition, we determined that FOXO1 turnover is involved in the regulation of this dynamic process. X-box binding protein 1u (XBP1u) plays a critical role in FOXO1 degradation by recruiting FOXO1 to the 20S proteasome. Moreover, the phosphorylation of XBP1u by mitogen-activated protein kinases 1 and 3 (MAPK1/3, also known as ERK2/1) on serine residues 61 and 176 was found to be essential for the enhancement of the interaction between XBP1u and FOXO1. Thus, our findings support the hypothesis that the turnover of FOXO1 induced by MAPK1/3 and XBP1u is a critical factor regulating the autophagic process.",
        "keywords": [
            "erk",
            "xbp1u",
            "foxo1",
            "cancer",
            "autophagy",
            "transcription factors",
            "dna binding proteins",
            "phosphorylation",
            "signal transduction"
        ],
        "authors": [
            {
                "name": "Ying Zhao",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Xue Li",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Ke Ma",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Jing Yang",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Jingyi Zhou",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Wan Fu",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Fuzheng Wei",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Lina Wang",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Wei-Guo Zhu",
                "org": "Peking University(Peking University),Beijing,China"
            }
        ],
        "venue": "Autophagy",
        "year": 2013
    },
    "CUtjCoDy": {
        "id": "CUtjCoDy",
        "title": "Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer.",
        "abstract": "Maintenance of p53 function is important for normal cell growth and development, and loss of p53 function contributes directly to malignant tumor development. The recently discovered Pirh2 protein is an ubiquitin-protein ligase that negatively regulates p53 through activity by targeting it for degradation. To determine how Pirh2 may mediate lung tumorigenesis, we evaluated Pirh2 expression in human and mouse lung tumor samples and paired normal lung tissues using immunoblot analysis and immunohistochemistry. Pirh2 protein expression was higher in 27 (84%) of 32 human lung neoplasms than in matched normal lung tissue and in 14 of 15 mouse lung tumors evaluated. In addition, p53 protein was more ubiquitinated in the mouse lung tumors than in normal tissue, and overall p53 expression was lower than that in normal tissue. These results are consistent with the hypothesis that increased Pirh2 expression affects lung tumorigenesis by reducing p53 activity. To our knowledge, this is the first description of altered Pirh2 expression in human and mouse tumors.",
        "keywords": [],
        "authors": [
            {
                "name": "Wenrui Duan",
                "org": ""
            },
            {
                "name": "Li Gao",
                "org": ""
            },
            {
                "name": "Lawrence J Druhan",
                "org": ""
            },
            {
                "name": "Wei-Guo Zhu",
                "org": ""
            },
            {
                "name": "Carl Morrison",
                "org": ""
            },
            {
                "name": "Gregory A Otterson",
                "org": ""
            },
            {
                "name": "Miguel A Villalona-Calero",
                "org": ""
            }
        ],
        "venue": "Journal of the National Cancer Institute",
        "year": 2004
    },
    "WhoZNb5y": {
        "id": "WhoZNb5y",
        "title": "Damage and Replication Stress Responses",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "haiying wang",
                "org": ""
            },
            {
                "name": "ping shen",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2011
    },
    "GdmW4HPb": {
        "id": "GdmW4HPb",
        "title": "Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway",
        "abstract": "",
        "keywords": [
            "mta2",
            "mtor pathway",
            "ezh2",
            "histone modification",
            "autophagy"
        ],
        "authors": [
            {
                "name": "fuzheng wei",
                "org": ""
            },
            {
                "name": "ziyang cao",
                "org": ""
            },
            {
                "name": "xi wang",
                "org": ""
            },
            {
                "name": "muyan cai",
                "org": ""
            },
            {
                "name": "tingting li",
                "org": ""
            },
            {
                "name": "naoko hattori",
                "org": ""
            },
            {
                "name": "donglai wang",
                "org": ""
            },
            {
                "name": "yipeng du",
                "org": ""
            },
            {
                "name": "boyan song",
                "org": ""
            },
            {
                "name": "linlin cao",
                "org": ""
            },
            {
                "name": "changchun shen",
                "org": ""
            },
            {
                "name": "lina wang",
                "org": ""
            },
            {
                "name": "haiying wang",
                "org": ""
            },
            {
                "name": "yang yang",
                "org": ""
            },
            {
                "name": "dan xie",
                "org": ""
            },
            {
                "name": "fan wang",
                "org": ""
            },
            {
                "name": "toshikazu ushijima",
                "org": ""
            },
            {
                "name": "ying zhao",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Autophagy",
        "year": 2016
    },
    "8e6tLDwB": {
        "id": "8e6tLDwB",
        "title": "The attenuation of vaccinia Tian Tan strain by the removal of the viral M1L-K2L genes",
        "abstract": "",
        "keywords": [
            "electron microscope",
            "cd8 t cell",
            "cell line",
            "body weight",
            "life cycle",
            "genetics",
            "viral vector"
        ],
        "authors": [
            {
                "name": "leibo liu",
                "org": "wuhan university"
            },
            {
                "name": "ke zhuang",
                "org": "wuhan university"
            },
            {
                "name": "z chen",
                "org": "wuhan university"
            },
            {
                "name": "po tien",
                "org": "wuhan university"
            },
            {
                "name": "jiannian zhou",
                "org": "wuhan university"
            },
            {
                "name": "lina zhang",
                "org": "wuhan university"
            },
            {
                "name": "wei yu",
                "org": "wuhan university"
            },
            {
                "name": "qi fang",
                "org": "wuhan university"
            },
            {
                "name": "weiguo zhu",
                "org": "wuhan university"
            },
            {
                "name": "haiying wang",
                "org": "wuhan university"
            }
        ],
        "venue": "Journal of Virological Methods",
        "year": 2007
    },
    "VdSreylM": {
        "id": "VdSreylM",
        "title": "P21 response to DNA damage induced by genistein and etoposide in human lung cancer cells.",
        "abstract": "The p21(WAF1/Cip1) gene plays a central role in cell cycle regulation. Here we show that topoisomerase II inhibitors, genistein and etoposide, induce p21(WAF1/Cip1) expression mainly in a p53-dependent manner in human lung cancer cell line A549. However, although p53 accumulated, p21(WAF1/Cip1) expression did not depend on the level of Ser15 phosphorylation of p53. Caffeine, an ataxia telangiectasia-mutated (ATM), and ATM- and Rad3-related kinase (ATR) inhibitor, abrogated genistein-induced p21(WAF1/Cip1) and largely blocked etoposide-induced p21(WAF1/Cip1) expression. Wortmannin, an ATM- and DNA-dependent protein kinase inhibitor, partially inhibited p21(WAF1/Cip1) expression induced by genistein and etoposide, whereas UCN-01, a Chk1 inhibitor, partially blocked etoposide, but not genistein-induced p21(WAF1/Cip1) expression. These data suggest that both genistein and etoposide induce p21(WAF1/Cip1) expression in a p53-dependent manner. Genistein appears to stimulate p21(WAF1/Cip1) expression through p53 via ATM, whereas etoposide may activate both ATM and ATR pathways. Our results suggest different mechanisms participate in genistein and etoposide induced p21(WAF1/Cip1) expression.",
        "keywords": [
            "p53",
            "genistein",
            "p21 waf1/cip1",
            "dna damage response",
            "dna-pks",
            "etoposide",
            "atr",
            "atm",
            "cell cycle regulation",
            "dna damage",
            "cell line"
        ],
        "authors": [
            {
                "name": "Haiming Ding",
                "org": "Department of Internal Medicine, The Ohio State University, Columbus, OH 43210-1240, USA"
            },
            {
                "name": "Wenrui Duan",
                "org": "Department of Internal Medicine, The Ohio State University, Columbus, OH 43210-1240, USA"
            },
            {
                "name": "Wei-Guo Zhu",
                "org": "Department of Internal Medicine, The Ohio State University, Columbus, OH 43210-1240, USA"
            },
            {
                "name": "Rong Ju",
                "org": "Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210-1240, USA"
            },
            {
                "name": "Kanur Srinivasan",
                "org": "Department of Internal Medicine, The Ohio State University, Columbus, OH 43210-1240, USA"
            },
            {
                "name": "Gregory A Otterson",
                "org": "Department of Internal Medicine, The Ohio State University, Columbus, OH 43210-1240, USA"
            },
            {
                "name": "Miguel A Villalona-Calero",
                "org": ""
            }
        ],
        "venue": "Biochemical and biophysical research communications",
        "year": 2003
    },
    "0E23BvR1": {
        "id": "0E23BvR1",
        "title": "ZD6474 induces growth arrest and apoptosis of GIST-T1 cells, which is enhanced by concomitant use of sunitinib.",
        "abstract": "ZD6474 (Zactima, AstraZeneca, Macclesfield, UK) is an orally available, small-molecule inhibitor of vascular endothelial growth factor receptor-2 and epidermal growth factor receptor tyrosine kinases, with additional activity versus rearranged during transfection (RET). This study explored the effect of ZD6474 in gastrointestinal stromal tumor-T1 (GIST-T1) cells that possess a gain of function mutation in exon 11 of the c-KIT gene. ZD6474 induced growth arrest and apoptosis of GIST-T1 cells in association with blockade of c-Kit and its downstream effectors, including Akt and extracellular signal-regulated kinase (ERK). ZD6474 treatment also blocked the mammalian target of rapamycin (mTOR), which lies downstream of Akt and ERK. Interestingly, when ZD6474 was combined with sunitinib (SU11248; Sutent, Pfizer, Kalamazoo, MI, USA), a class III and V receptor tyrosine kinase inhibitor, the ZD6474-mediated growth inhibition was potentiated in association with further down-regulation of the mTOR targets p-p70S6K and p-4E-BP-1. The combination of ZD6474 and sunitinib should be investigated further.",
        "keywords": [],
        "authors": [
            {
                "name": "Yang Yang",
                "org": ""
            },
            {
                "name": "Takayuki Ikezoe",
                "org": ""
            },
            {
                "name": "Chie Nishioka",
                "org": ""
            },
            {
                "name": "Takahiro Taguchi",
                "org": ""
            },
            {
                "name": "Wei-Guo Zhu",
                "org": ""
            },
            {
                "name": "H Phillip Koeffler",
                "org": ""
            },
            {
                "name": "Hirokuni Taguchi",
                "org": ""
            }
        ],
        "venue": "Cancer science",
        "year": 2006
    },
    "dNMMrBUN": {
        "id": "dNMMrBUN",
        "title": "The changing face of HDAC inhibitor depsipeptide.",
        "abstract": "Histone deacetylase (HDAC) inhibitors are currently used in the study of epigenetics and have potential in clinical cancer therapy. A novel and potent HDAC inhibitor, depsipeptide, also known as FK228 or FR901228, is highly efficient in inhibiting the activity of HDACs even at nanomolar concentrations. Depsipeptide has a unique structure that is distinct from most of the other HDACs, and it thus exhibits diverse pharmacologic functions. In addition, depsipeptide has a metabolic activation pathway, which affects many intracellular processes. However, the specific features of this pathway are as yet not completely worked out. In this article, we will focus on the uniqueness of this molecule's specific structure, the relationship of this structure to its putative metabolic activation pathway, and specifically review its newly discovered biological functions and clinical applications.",
        "keywords": [],
        "authors": [
            {
                "name": "Wen Zhou",
                "org": ""
            },
            {
                "name": "Wei-Guo Zhu",
                "org": ""
            }
        ],
        "venue": "Current cancer drug targets",
        "year": 2009
    },
    "4ZqkIa20": {
        "id": "4ZqkIa20",
        "title": "HDAC inhibitors act with 5-aza-2'-deoxycytidine to inhibit cell proliferation by suppressing removal of incorporated abases in lung cancer cells.",
        "abstract": "5-Aza-2'-deoxycytidine (5-aza-CdR) is used extensively as a demethylating agent and acts in concert with histone deacetylase inhibitors (HDACI) to induce apoptosis or inhibition of cell proliferation in human cancer cells. Whether the action of 5-aza-CdR in this synergistic effect results from demethylation by this agent is not yet clear. In this study we found that inhibition of cell proliferation was not observed when cells with knockdown of DNA methyltransferase 1 (DNMT1), or double knock down of DNMT1-DNMT3A or DNMT1-DNMT3B were treated with HDACI, implying that the demethylating function of 5-aza-CdR may be not involved in this synergistic effect. Further study showed that there was a causal relationship between 5-aza-CdR induced DNA damage and the amount of [(3)H]-5-aza-CdR incorporated in DNA. However, incorporated [(3)H]-5-aza-CdR gradually decreased when cells were incubated in [(3)H]-5-aza-CdR free medium, indicating that 5-aza-CdR, which is an abnormal base, may be excluded by the cell repair system. It was of interest that HDACI significantly postponed the removal of the incorporated [(3)H]-5-aza-CdR from DNA. Moreover, HDAC inhibitor showed selective synergy with nucleoside analog-induced DNA damage to inhibit cell proliferation, but showed no such effect with other DNA damage stresses such as gamma-ray and UV, etoposide or cisplatin. This study demonstrates that HDACI synergistically inhibits cell proliferation with nucleoside analogs by suppressing removal of incorporated harmful nucleotide analogs from DNA.",
        "keywords": [
            "dna damage",
            "nucleotides",
            "cell proliferation"
        ],
        "authors": [
            {
                "name": "Guolin Chai",
                "org": ""
            },
            {
                "name": "Lian Li",
                "org": ""
            },
            {
                "name": "Wen Zhou",
                "org": ""
            },
            {
                "name": "Lipeng Wu",
                "org": ""
            },
            {
                "name": "Ying Zhao",
                "org": ""
            },
            {
                "name": "Donglai Wang",
                "org": ""
            },
            {
                "name": "Shaoli Lu",
                "org": ""
            },
            {
                "name": "Yu Yu",
                "org": ""
            },
            {
                "name": "Haiying Wang",
                "org": ""
            },
            {
                "name": "Michael A McNutt",
                "org": ""
            },
            {
                "name": "Ye-Guang Hu",
                "org": ""
            },
            {
                "name": "Yingqi Chen",
                "org": ""
            },
            {
                "name": "Yang Yang",
                "org": ""
            },
            {
                "name": "Xin Wu",
                "org": ""
            },
            {
                "name": "Gregory A Otterson",
                "org": ""
            },
            {
                "name": "Wei-Guo Zhu",
                "org": ""
            }
        ],
        "venue": "PloS one",
        "year": 2008
    },
    "pfmnPl3H": {
        "id": "pfmnPl3H",
        "title": "Deficiency of hepatocystin induces autophagy through an mTOR-dependent pathway.",
        "abstract": "Mutations in the gene encoding hepatocystin/80K-H (PRKCSH) cause autosomal-dominant polycystic liver disease (ADPLD). Hepatocystin functions in the processing of nascent glycoproteins as the noncatalytic beta subunit of glucosidase II (Glu II) and regulates calcium release from endoplasmic reticulum (ER) through the inositol 1,4,5-trisphosphate receptor (IP3R). Little is known, however, on how cells respond to a deficiency of hepatocystin. In this study, we demonstrate that knockdown of hepatocystin induces autophagy, the major intracellular degradation pathway essential for cellular health. Ectopic expression of wild-type hepatocystin, but not pathogenic mutants, rescues the siRNA-induced effect. Our data indicate that the induction of autophagy by hepatocystin deficiency is mediated through mammalian target of rapamycin (mTOR). Despite the resulting severe reduction in Glu II activity, the unfolded protein response (UPR) pathway is not disturbed. Furthermore, the inhibition of IP3R-mediated transient calcium flux is not required for the induction of autophagy. These results provide new insights into the function of hepatocysin and the regulation of autophagy.",
        "keywords": [
            "mtor",
            "polycystic liver",
            "autophagy",
            "glucosidase ii",
            "hepatocystin (prkcsh)"
        ],
        "authors": [
            {
                "name": "Jing Yang",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Ying Zhao",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Ke Ma",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Fen-Jun Jiang",
                "org": "Nankai University(Nankai University),Tianjin,China"
            },
            {
                "name": "Wenjuan Liao",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Ping Zhang",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Jingyi Zhou",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Bo Tu",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Lina Wang",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Harm H Kampinga",
                "org": "Universitair Medisch Centrum Groningen(University Hospital Groningen,University Medical Center Groningen,University Hospital),Groningen,Netherlands"
            },
            {
                "name": "Zhiping Xie",
                "org": "Nankai University(Nankai University),Tianjin,China"
            },
            {
                "name": "Wei-Guo Zhu",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            }
        ],
        "venue": "Autophagy",
        "year": 2011
    },
    "30mb7hvX": {
        "id": "30mb7hvX",
        "title": "Acetylation of FoxO1 Activates Bim Expression to Induce Apoptosis in Response to Histone Deacetylase Inhibitor Depsipeptide Treatment1,2",
        "abstract": "Histone deacetylase (HDAC) inhibitors have been shown to induce cell cycle arrest and apoptosis in cancer cells. How- ever, the mechanisms of HDAC inhibitor induced apoptosis are incompletely understood. In this study, depsipeptide, a novel HDAC inhibitor, was shown to be able to induce significant apoptotic cell death in human lung cancer cells. Further study showed that Bim, a BH3-only proapoptotic protein, was significantly upregulated by depsipeptide in can- cer cells, and Bim's function in depsipeptide-induced apoptosis was confirmed by knockdown of Bim with RNAi. In addition, we found that depsipeptide-induced expression of Bim was directly dependent on acetylation of forkhead box class O1 (FoxO1) that is catalyzed by cyclic adenosine monophosphate-responsive element-binding protein-binding protein, and indirectly induced by a decreased four-and-a-half LIM-domain protein 2. Moreover, our results demon- strated that FoxO1 acetylation is required for the depsipeptide-induced activation of Bim and apoptosis, using transfec- tion with a plasmid containing FoxO1 mutated at lysine sites and a luciferase reporter assay. These data show for the first time that an HDAC inhibitor induces apoptosis through the FoxO1 acetylation-Bim pathway.",
        "keywords": [],
        "authors": [
            {
                "name": "Yang Yang",
                "org": ""
            },
            {
                "name": "Ying Zhao",
                "org": ""
            },
            {
                "name": "Wenjuan Liao",
                "org": ""
            },
            {
                "name": "Jing Yang",
                "org": ""
            },
            {
                "name": "Lipeng Wu",
                "org": ""
            },
            {
                "name": "Zhixing Zheng",
                "org": ""
            },
            {
                "name": "Yu Yu",
                "org": ""
            },
            {
                "name": "Wen Zhou",
                "org": ""
            },
            {
                "name": "Lian Li",
                "org": ""
            },
            {
                "name": "Jingnan Feng",
                "org": ""
            },
            {
                "name": "Haiying Wang",
                "org": ""
            },
            {
                "name": "Wei-Guo Zhu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 0
    },
    "hy8gE0DG": {
        "id": "hy8gE0DG",
        "title": "Saw Palmetto induces growth arrest and apoptosis of androgen-dependent prostate cancer LNCaP cells via inactivation of STAT 3 and androgen receptor signaling.",
        "abstract": "PC-SPES is an eight-herb mixture that has an activity against prostate cancer. Recently, we purified Saw Palmetto (Serenoa repens) from PC-SPES and found that Saw Palmetto induced growth arrest of prostate cancer LNCaP, DU145, and PC3 cells with ED50s of approximately 2.0, 2.6, and 3.3 microl/ml, respectively, as measured by mitochondrial-dependent conversion of the the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Saw Palmetto induced apoptosis of LNCaP cells in a time- and dose-dependent manner as measured by TUNEL assays. Also, Saw Palmetto increased the expression of p21waf1 and p53 protein in LNCaP cells. In addition, we found that Saw Palmetto down-regulated DHT- or IL-6-induced expression of prostate specific antigen in conjunction with down-regulation of the level of androgen receptor in the nucleus as measured by Western blot analysis. Moreover, Saw Palmetto down-regulated the IL-6-induced level of the phosphorylated form of STAT 3 in LNCaP cells. Furthermore, Saw Palmetto inhibited the growth of LNCaP cells present as tumor xenografts in BALB/c nude mice without adverse effect. These results indicate that Saw Palmetto might be useful for the treatment of individuals with prostate cancer.",
        "keywords": [
            "stat 3",
            "prostate cancer",
            "saw palometto",
            "androgen receptor",
            "psa",
            "cancer",
            "molecular medicine",
            "cell",
            "apoptosis",
            "gene",
            "cell cycle",
            "oncology"
        ],
        "authors": [
            {
                "name": "Yang Yang",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Takayuki Ikezoe",
                "org": "Kochi University(Kochi University),Kochi,Japan"
            },
            {
                "name": "Zhixing Zheng",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Hirokuni Taguchi",
                "org": "Kochi University(Kochi University),Kochi,Japan"
            },
            {
                "name": "H Phillip Koeffler",
                "org": "David Geffen School of Medicine at UCLA(UCLA School of Medicine),Los Angeles,United States"
            },
            {
                "name": "Wei-Guo Zhu",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            }
        ],
        "venue": "International journal of oncology",
        "year": 2007
    },
    "wCyDi6XE": {
        "id": "wCyDi6XE",
        "title": "Acetylation of Fox01 activates b i m expression to induce apoptosis in response to Histone deacetylase inhibitor depsipeptide treatment12 www.neoplasia.com",
        "abstract": "Histone deacetylase (HDAC) inhibitors have been shown to induce cell cycle arrest and apoptosis in cancer cells. How- ever, the mechanisms of HDAC inhibitor induced apoptosis are incompletely understood. In this study, depsipeptide, a novel HDAC inhibitor, was shown to be able to induce significant apoptotic cell death in human lung cancer cells. Further study showed that Bim, a BH3-only proapoptotic protein, was significantly upregulated by depsipeptide in can- cer cells, and Bim's function in depsipeptide-induced apoptosis was confirmed by knockdown of Bim with RNAi. In addition, we found that depsipeptide-induced expression of Bim was directly dependent on acetylation of forkhead box class 01 (Fox01) that is catalyzed by cyclic adenosine monophosphate-responsive element-binding protein-binding protein, and indirectly induced by a decreased four-and-a-half LIM-domain protein 2. Moreover, our results demon- strated that Fox01 acetylation is required for the depsipeptide-induced activation of Bim and apoptosis, using transfec- tion with a plasmid containing Fox01 mutated at lysine sites and a luciferase reporter assay. These data show for the first time that an HDAC inhibitor induces apoptosis through the Fox01 acetylation-Bim pathway. Copyright \u00a9 2009 Neoplasia Press, Inc. All rights reserved.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Yang Yang",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Ying Zhao",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Wonjuan Liao",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Jing Yang",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Lipeng Wu",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Zhixing Zhung",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Yu Yu",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Wen Zhou",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Lian Li",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Jingnan Feng",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Haiying Wang",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            }
        ],
        "venue": "Neoplasia",
        "year": 2009
    },
    "qXnrcwFV": {
        "id": "qXnrcwFV",
        "title": "Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability.",
        "abstract": "Suppressor of variegation 3-9 homolog 1 (SUV39H1), a histone methyltransferase, catalyzes histone 3 lysine 9 trimethylation and is involved in heterochromatin organization and genome stability. However, the mechanism for regulation of the enzymatic activity of SUV39H1 in cancer cells is not yet well known. In this study, we identified SET domain-containing protein 7 (SET7/9), a protein methyltransferase, as a unique regulator of SUV39H1 activity. In response to treatment with adriamycin, a DNA damage inducer, SET7/9 interacted with SUV39H1 in vivo, and a GST pull-down assay confirmed that the chromodomain-containing region of SUV39H1 bound to SET7/9. Western blot using antibodies specific for antimethylated SUV39H1 and mass spectrometry demonstrated that SUV39H1 was specifically methylated at lysines 105 and 123 by SET7/9. Although the half-life and localization of methylated SUV39H1 were not noticeably changed, the methyltransferase activity of SUV39H1 was dramatically down-regulated when SUV39H1 was methylated by SET7/9. Consequently, H3K9 trimethylation in the heterochromatin decreased significantly, which, in turn, led to a significant increase in the expression of satellite 2 (Sat2) and \u03b1-satellite (\u03b1-Sat), indicators of heterochromatin relaxation. Furthermore, a micrococcal nuclease sensitivity assay and an immunofluorescence assay demonstrated that methylation of SUV39H1 facilitated genome instability and ultimately inhibited cell proliferation. Together, our data reveal a unique interplay between SET7/9 and SUV39H1--two histone methyltransferases--that results in heterochromatin relaxation and genome instability in response to DNA damage in cancer cells.",
        "keywords": [
            "repressor proteins",
            "genomic instability",
            "heterochromatin",
            "chromatin immunoprecipitation",
            "real time polymerase chain reaction",
            "dna methylation",
            "dna primers",
            "methyltransferases",
            "immunoprecipitation"
        ],
        "authors": [
            {
                "name": "Donglai Wang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education),;Department of Biochemistry and Molecular Biology, and"
            },
            {
                "name": "Jingyi Zhou",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education),;Department of Biochemistry and Molecular Biology, and"
            },
            {
                "name": "Xiangyu Liu",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education),;Department of Biochemistry and Molecular Biology, and"
            },
            {
                "name": "Danyu Lu",
                "org": "Department of Anatomy, Histology, and Embryology, Peking University Health Science Center, Beijing 100191, China;"
            },
            {
                "name": "Changchun Shen",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education),;Department of Biochemistry and Molecular Biology, and"
            },
            {
                "name": "Yipeng Du",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education),;Department of Biochemistry and Molecular Biology, and"
            },
            {
                "name": "Fu-Zheng Wei",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education),;Department of Biochemistry and Molecular Biology, and"
            },
            {
                "name": "Boyan Song",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education),;Department of Biochemistry and Molecular Biology, and"
            },
            {
                "name": "Xiaopeng Lu",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education),;Department of Biochemistry and Molecular Biology, and"
            },
            {
                "name": "Yu Yu",
                "org": "Department of Anatomy, Histology, and Embryology, Peking University Health Science Center, Beijing 100191, China;"
            },
            {
                "name": "Lina Wang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education),;Department of Biochemistry and Molecular Biology, and"
            },
            {
                "name": "Ying Zhao",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education),;Department of Biochemistry and Molecular Biology, and"
            },
            {
                "name": "Haiying Wang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education),;Department of Biochemistry and Molecular Biology, and"
            },
            {
                "name": "Yang Yang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education),;Department of Biochemistry and Molecular Biology, and"
            },
            {
                "name": "Yoshimitsu Akiyama",
                "org": "Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-0034, Japan"
            },
            {
                "name": "Hongquan Zhang",
                "org": "Department of Anatomy, Histology, and Embryology, Peking University Health Science Center, Beijing 100191, China;"
            },
            {
                "name": "Wei-Guo Zhu",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education),;Department of Biochemistry and Molecular Biology, and;Peking-Tsinghua University Center for Life Science, Peking University, Beijing 100871, China"
            }
        ],
        "venue": "Proceedings of the National Academy of Sciences of the United States of America",
        "year": 2013
    },
    "h9QF1smM": {
        "id": "h9QF1smM",
        "title": "SET7/9 regulates cancer cell proliferation by influencing \u03b2-catenin stability",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "changchun shen",
                "org": ""
            },
            {
                "name": "donglai wang",
                "org": ""
            },
            {
                "name": "xiangyu liu",
                "org": ""
            },
            {
                "name": "bo gu",
                "org": ""
            },
            {
                "name": "yipeng du",
                "org": ""
            },
            {
                "name": "fuzheng wei",
                "org": ""
            },
            {
                "name": "linlin cao",
                "org": ""
            },
            {
                "name": "boyan song",
                "org": ""
            },
            {
                "name": "xiaopeng lu",
                "org": ""
            },
            {
                "name": "qiaoyan yang",
                "org": ""
            },
            {
                "name": "qian zhu",
                "org": ""
            },
            {
                "name": "tianyun hou",
                "org": ""
            },
            {
                "name": "meiting li",
                "org": ""
            },
            {
                "name": "lina wang",
                "org": ""
            },
            {
                "name": "haiying wang",
                "org": ""
            },
            {
                "name": "ying zhao",
                "org": ""
            },
            {
                "name": "yang yang",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "The FASEB Journal",
        "year": 2015
    },
    "7wc4GoPU": {
        "id": "7wc4GoPU",
        "title": "A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes.",
        "abstract": "Amplification of oncogenes is an important mechanism that can cause gene overexpression and contributes to tumor development. The identification of amplified regions might have both prognostic and therapeutic significance. We used primary lung carcinomas and lung cancer cell lines for restriction landmark genomic scanning (RLGS) to identify novel amplified sequences. Enhanced RLGS fragments that indicate gene amplification were observed in primary tumors and lung cancer cell lines of both non-small cell lung cancer and small cell lung cancer. We identified one novel amplicon on chromosome 11q22, in addition to previously reported amplicons that include oncogenes MYCC, MYCL1 and previously identified amplification of chromosomal regions 6q21 and 3q26-27. Amplification of 11q22 has been reported in other types of cancer and was refined to an approximately 1.19 Mbp region for which the complete sequence is available. Based on a patient sample with a small region of low-level amplification we were able to further narrow this region to 0.92 Mbp. Genes localized in this region include two inhibitors of apoptosis (cIAP1 and cIAP2). Immunohistochemistry and western blot analysis identified cIAP1 and cIAP2 as potential oncogenes in this region as both are overexpressed in multiple lung cancers with or without higher copy numbers.",
        "keywords": [
            "identification",
            "apoptose",
            "immunohistochemistry",
            "dna",
            "gene amplification",
            "copy number",
            "restriction landmark genomic scanning",
            "apoptosis",
            "cell line"
        ],
        "authors": [
            {
                "name": "Zunyan Dai",
                "org": "Program of Human Cancer Genetics|Department of Molecular Virology|Immunology and Medical Genetics"
            },
            {
                "name": "Wei-Guo Zhu",
                "org": ""
            },
            {
                "name": "Carl D Morrison",
                "org": "Program of Human Cancer Genetics|Department of Molecular Virology|Immunology and Medical Genetics"
            },
            {
                "name": "Romulo M Brena",
                "org": "Program of Human Cancer Genetics|Department of Molecular Virology|Immunology and Medical Genetics"
            },
            {
                "name": "Dominic J Smiraglia",
                "org": "Program of Human Cancer Genetics|Department of Molecular Virology|Immunology and Medical Genetics"
            },
            {
                "name": "Aparna Raval",
                "org": "Program of Human Cancer Genetics|Department of Molecular Virology|Immunology and Medical Genetics"
            },
            {
                "name": "Yue-Zhong Wu",
                "org": "Program of Human Cancer Genetics|Department of Molecular Virology|Immunology and Medical Genetics"
            },
            {
                "name": "Laura J Rush",
                "org": "Program of Human Cancer Genetics|Department of Molecular Virology|Immunology and Medical Genetics"
            },
            {
                "name": "Patrick Ross",
                "org": ""
            },
            {
                "name": "Julian R Molina",
                "org": ""
            },
            {
                "name": "Gregory A Otterson",
                "org": ""
            },
            {
                "name": "Christoph Plass",
                "org": "Program of Human Cancer Genetics|Department of Molecular Virology|Immunology and Medical Genetics"
            }
        ],
        "venue": "Human molecular genetics",
        "year": 2003
    },
    "iLQrYB6z": {
        "id": "iLQrYB6z",
        "title": "Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.",
        "abstract": "In mammalian cells, tumor suppressor p53 plays critical roles in the regulation of glucose metabolism, including glycolysis and oxidative phosphorylation, but whether and how p53 also regulates gluconeogenesis is less clear. Here, we report that p53 efficiently down-regulates the expression of phosphoenolpyruvate carboxykinase (PCK1) and glucose-6-phosphatase (G6PC), which encode rate-limiting enzymes in gluconeogenesis. Cell-based assays demonstrate the p53-dependent nuclear exclusion of forkhead box protein O1 (FoxO1), a key transcription factor that mediates activation of PCK1 and G6PC, with consequent alleviation of FoxO1-dependent gluconeogenesis. Further mechanistic studies show that p53 directly activates expression of the NAD(+)-dependent histone deacetylase sirtuin 6 (SIRT6), whose interaction with FoxO1 leads to FoxO1 deacetylation and export to the cytoplasm. In support of these observations, p53-mediated FoxO1 nuclear exclusion, down-regulation of PCK1 and G6PC expression, and regulation of glucose levels were confirmed in C57BL/J6 mice and in liver-specific Sirt6 conditional knockout mice. Our results provide insights into mechanisms of metabolism-related p53 functions that may be relevant to tumor suppression.",
        "keywords": [],
        "authors": [
            {
                "name": "Ping Zhang",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China;"
            },
            {
                "name": "Bo Tu",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China;"
            },
            {
                "name": "Hua Wang",
                "org": "Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892;"
            },
            {
                "name": "Ziyang Cao",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China;"
            },
            {
                "name": "Ming Tang",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China;"
            },
            {
                "name": "Chaohua Zhang",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China;"
            },
            {
                "name": "Bo Gu",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China;"
            },
            {
                "name": "Zhiming Li",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China;"
            },
            {
                "name": "Lina Wang",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China;"
            },
            {
                "name": "Yang Yang",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China;"
            },
            {
                "name": "Ying Zhao",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China;"
            },
            {
                "name": "Haiying Wang",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China;"
            },
            {
                "name": "Jianyuan Luo",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China;"
            },
            {
                "name": "Chu-Xia Deng",
                "org": "Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;"
            },
            {
                "name": "Bin Gao",
                "org": "Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892;"
            },
            {
                "name": "Robert G Roeder",
                "org": "Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065"
            },
            {
                "name": "Wei-Guo Zhu",
                "org": "Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China;;Center for Life Sciences, Peking-Tsinghua University, Beijing 100871, China"
            }
        ],
        "venue": "Proceedings of the National Academy of Sciences of the United States of America",
        "year": 2014
    },
    "zpSUP7sC": {
        "id": "zpSUP7sC",
        "title": "DNA methyltransferases: the role in regulation of gene expression and biological processes]",
        "abstract": "Both hitone modification and DNA methylation remodulate chromatin structure and control gene expression or silence. As a main enzyme for DNA methylation, DNA methyltransferase (Dnmt) is not only associated with DNA methylation, but also links to many important biological activities, including cell proliferation, senescence and cancer development. This review focuses on structure, regulation and function in biological processes of Dnmt.",
        "keywords": [
            "epigenetics",
            "dna methylation",
            "dna methyltransferase"
        ],
        "authors": [
            {
                "name": "Yu SU",
                "org": ""
            },
            {
                "name": "Xi WANG",
                "org": ""
            },
            {
                "name": "Wei-Guo ZHU",
                "org": ""
            }
        ],
        "venue": "Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji",
        "year": 2009
    },
    "u0liUERx": {
        "id": "u0liUERx",
        "title": "Promotion of Heat-Induced Apoptosis in FM3A Cells by Protease Inhibitors",
        "abstract": "Although it has been shown that proteases may play a positive role in in causing apoptosis of some cells, we report here that, on the contrary, protease inhibitors can promote heat-induced apoptosis in FM3A cells. Cysteine protease inhibitor, trans-Epoxy-succinyl-L-leucylamido-(4-guanidino)butane (E-64, 100 micrograms/ml) and aspartate protease inhibitor, pepstatin-A (100 micrograms/ml) were used to test hyperthermic effect on FM3A cells and showed remarkable cytotoxicity when they were present in cell suspension during heating at 44 degrees C. The cytotoxicity was due to promotion of heat-induced apoptosis as judged by DNA agarose electrophoresis. Furthermore, using flow cytometric analysis, we observed a decrease in the G0/G1 phase cell and an increase in the S phase cell as well as increased apoptosis after heat shock. E-64 and pepstatin-A exhibited a promotive effect on the changes of cell cycle induced by heat. The data presented suggest that the enhancement of hyperthermic cell killing by protease inhibitors may be related to promotion of heat-induced apoptosis and changes of cell cycle.",
        "keywords": [
            "cell cycle",
            "heat shock"
        ],
        "authors": [
            {
                "name": "Wei-Guo Zhu",
                "org": "Department of Experimental Radiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan. weiguo@houki.med.kyushu-u.ae.jp"
            },
            {
                "name": "Ryoji Aramaki",
                "org": "Department of Experimental Radiology, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-82, Japan"
            },
            {
                "name": "Yong Cai",
                "org": "Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-82, Japan"
            },
            {
                "name": "Shigetoshi Antoku",
                "org": "Department of Experimental Radiology, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-82, Japan"
            }
        ],
        "venue": "Biochemical and Biophysical Research Communications",
        "year": 1996
    },
    "lXxl3xlP": {
        "id": "lXxl3xlP",
        "title": "Mechanism of regulating deacetylase SIRT1 expression and activity.]",
        "abstract": "SIRT1 is an NAD+-dependent deacetylase in mammalian cells and plays important roles in senescence, cell death and tumorigenesis. To clarify the regulation of SIRT1 expression and activity is crucial for scientists to understand the biological function of SIRT1. This review mainly focuses on the mechanisms by which SIRT1 expression and activity are regulated.",
        "keywords": [
            "regulatory mechanism",
            "gene expression",
            "sirt1",
            "activity"
        ],
        "authors": [
            {
                "name": "Wen-Jia Yang",
                "org": " School of Basic Medical Sciences,Peking University,Beijing ,China"
            },
            {
                "name": "Dong-Lai Wang",
                "org": " School of Basic Medical Sciences,Peking University,Beijing ,China"
            },
            {
                "name": "Wei-Guo Zhu",
                "org": " School of Basic Medical Sciences,Peking University,Beijing ,China"
            }
        ],
        "venue": "Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji",
        "year": 2010
    },
    "yQcNUSdA": {
        "id": "yQcNUSdA",
        "title": "Bone morphogenetic protein 3B silencing in non-small-cell lung cancer.",
        "abstract": "Bone morphogenetic protein 3B (BMP3B) is a member of the TGF-beta superfamily. The BMP3B promoter sequence was previously identified as a target for aberrant DNA methylation in non-small-cell lung cancer (NSCLC). Aberrant DNA hypermethylation in the BMP3B promoter is associated with downregulation of BMP3B transcription in both primary human lung cancers as well as lung cancer cell lines. In order to understand the mechanisms of BMP3B silencing in lung cancer, a sample set of 91 primary NSCLCs was used to detect aberrant BMP3B promoter methylation, mutations in the coding sequence of BMP3B, and loss of heterozygosity (LOH). Our results showed that 45 of 91 (or 49.5%) tested primary NSCLCs exhibited increased promoter methylation, and 40% demonstrated LOH in at least one of the flanking microsatellite markers sJRH and D10S196 (63 kb upstream or 3.338 Mbp downstream of BMP3B). The lung cancer cell line A549, a type II alveolar epithelial human lung cancer cell line, is characterized by aberrant DNA promoter methylation. We used retroviral vector constructs containing the BMP3B cDNA to re-express the gene in A549 cells and to investigate the effects on cell growth. No change in the cell growth rate was observed after BMP3B re-expression, as compared to the vector controls. Although the number of colonies formed in anchorage-dependent assays was only slightly decreased, the colony-forming ability of A549 cells after BMP3B expression in anchorage-independent assays in soft agar was significantly reduced to 10% (P<0.005, t-test). Moreover, the in vivo tumorigenicity assay in nude mice indicated that cells re-expressing BMP3B grew significantly slower than cells not expressing BMP3B (P<0.05, t-test). In conclusion, this study provides evidence that BMP3B expression is repressed by different mechanisms in lung cancer, and that the silencing of BMP3B promotes lung tumor development.",
        "keywords": [
            "ONC",
            " oncogenes",
            " cancer",
            " apoptosis",
            " tumor suppressor genes",
            " tumor viruses",
            " molecular oncology",
            " cell cycle",
            " growth factors",
            " growth factor receptors",
            " growth regulatory genes"
        ],
        "authors": [
            {
                "name": "Zunyan Dai",
                "org": ""
            },
            {
                "name": "Anthony P Popkie",
                "org": ""
            },
            {
                "name": "Wei-Guo Zhu",
                "org": ""
            },
            {
                "name": "Cynthia D Timmers",
                "org": ""
            },
            {
                "name": "Aparna Raval",
                "org": ""
            },
            {
                "name": "sarah h tannehillgregg",
                "org": ""
            },
            {
                "name": "Carl D Morrison",
                "org": ""
            },
            {
                "name": "Herbert Auer",
                "org": ""
            },
            {
                "name": "Robert A Kratzke",
                "org": ""
            },
            {
                "name": "gloria a niehans",
                "org": ""
            },
            {
                "name": "Stefan Amatschek",
                "org": ""
            },
            {
                "name": "Wolfgang Sommergruber",
                "org": ""
            },
            {
                "name": "Gustavo W Leone",
                "org": ""
            },
            {
                "name": "thomas j rosol",
                "org": ""
            },
            {
                "name": "Gregory A Otterson",
                "org": ""
            },
            {
                "name": "Christoph Plass",
                "org": ""
            }
        ],
        "venue": "Oncogene",
        "year": 2004
    },
    "ZKMJDFQg": {
        "id": "ZKMJDFQg",
        "title": "The comet assay: a sensitive method for detecting DNA damage in individual cells.",
        "abstract": "The comet assay is a sensitive and rapid method for DNA strand break detection in individual cells, and the year 2009 represents the 25th anniversary of the first description of this methodology in 1984. Over time this method has been improved, but is still not completely standardized, and variations are currently in widespread use with emphasis on applications in research and genetic toxicology. Here we review the principles of the comet assay and cite key studies that have focused on this assay in the past 25 years. In addition, we present an example of how the comet assay was used in our laboratory for studying the induction of DNA damage in human lung cancer cells after differing doses of the cytosine analog 5-aza-2'-deoxycytidine (5-aza-CdR). Finally, some insights into the potential of this assay in cancer research and work in related fields are offered.",
        "keywords": [
            "dna damage",
            "genetics"
        ],
        "authors": [
            {
                "name": "Wenjuan Liao",
                "org": ""
            },
            {
                "name": "Michael A McNutt",
                "org": ""
            },
            {
                "name": "Wei-Guo Zhu",
                "org": ""
            }
        ],
        "venue": "Methods (San Diego, Calif.)",
        "year": 2009
    },
    "y781KCK2": {
        "id": "y781KCK2",
        "title": "Relationship Between Autophagy and Tumorigenesis",
        "abstract": "Autophagy is a highly conserved catabolic process that degrades a bulk of misfolded or damaged proteins and organelles.In normal cells,autophagy functions primarily to maintain the cellular homeostasis and is responsible for the regulation of organelle turnover.In response to various cellular stresses,autophagy plays a crucial role in preventing the accumulation of damaged proteins and organelles which are toxic and carcinogenic.However,autophagy can promote tumor growth once the tumors are formed by supplying nutrition and energy to tumors.Thus autophagy exhibits the effects of a double-blade sword in cancers,where most tumor suppressors act as inducers of autophagy and oncogenes play inhibitory roles in autophagy.Yet an exceptional case has been reported-tumor suppressor p53 suppresses the induction of autophagy in the cytoplasm.In this review,we focus on the discussion about the relationship between autophagy and tumor development.",
        "keywords": [
            "p53",
            "FoxO",
            "mTOR",
            "autophagy",
            "Beclin 1",
            "cancer"
        ],
        "authors": [
            {
                "name": "WANG Chong",
                "org": "Department of Biochemistry and Molecular Biology,Peking University Health Science Center,Beijing ,China"
            },
            {
                "name": "ZHANG Ping",
                "org": "Department of Biochemistry and Molecular Biology,Peking University Health Science Center,Beijing ,China"
            },
            {
                "name": "ZHU Wei-Guo",
                "org": "Department of Biochemistry and Molecular Biology,Peking University Health Science Center,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Biochemistry and Molecular Biology",
        "year": 2010
    },
    "bVugbYp0": {
        "id": "bVugbYp0",
        "title": "Advances in histone methyltransferases and histone demethylases]",
        "abstract": "Histone modification as one of the key epigenetic regulation mechanisms plays critical roles in various biological processes, including regulation of chromatin structure dynamics and gene expression. Both histone methyltransferase and histone demethylases contribute to the establishment and maintenance of different histone methylation status. The 'effectors' which can recognize histone methylated sites build a relationship between these modifications and their down stream processes. This review summarized recent advances in histone methyltransferases and histone demethylases.",
        "keywords": [
            "histone methyltransferase",
            "epigenetics",
            "histone demethylases"
        ],
        "authors": [
            {
                "name": "Xi Wang",
                "org": " Department of Biochemistry and Molecular Biology,Peking University,Health Science Center,Beijing, P.R.China"
            },
            {
                "name": "Wei-Guo Zhu",
                "org": " Department of Biochemistry and Molecular Biology,Peking University,Health Science Center,Beijing, P.R.China"
            }
        ],
        "venue": "Ai zheng = Aizheng = Chinese journal of cancer",
        "year": 2008
    },
    "c7nmKc4e": {
        "id": "c7nmKc4e",
        "title": "DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors.",
        "abstract": "Histone acetylation has long been associated with transcriptional acti- vation, whereas conversely, deacetylation of histones is associated with gene silencing and transcriptional repression. Here we report that inhib- itors of histone deacetylase (HDAC), depsipeptide and trichostatin A, induce apoptotic cell death in human lung cancer cells as demonstrated by DNA flow cytometry and Western immunoblot to detect cleavage of poly(ADP-ribose) polymerase. This HDAC inhibitorinduced apoptosis is greatly enhanced in the presence of the DNA methyltransferase inhibitor, 5-aza-2*-deoxycytidine (DAC). The HDAC inhibitor-induced apoptosis appears to be p53 independent, because no change in apoptotic cell death was observed in H1299 cells that expressed exogenous wild-type p53 (H1299 cells express no endogenous p53 protein). To further investigate the mechanism of DAC-enhanced, HDAC inhibitor-induced apoptosis, we analyzed histone H3 and H4 acetylation by Western immunoblotting. Results showed that depsipeptide induced a dose-dependent acetylation of histones H3 and H4, which was greatly increased in DAC-pretreated cells. By analyzing the acetylation of specific lysine residues at the amino terminus of histone H4 (Ac-5, Ac-8, Ac-12, and Ac-16), we found that the enhancement of HDAC inhibitor-induced acetylation of histones in the DAC-pretreated cells was not lysine site specific. These results demon- strate that DNA methylation status is an important determinant of apo- ptotic susceptibility to HDAC inhibitors.",
        "keywords": [
            "cell death",
            "gene silencing",
            "poly adp ribose polymerase",
            "dna methylation",
            "flow cytometry",
            "wild type"
        ],
        "authors": [
            {
                "name": "Wei-Guo Zhu",
                "org": "Department of Internal Medicine and the Comprehensive Cancer Center, The Ohio State University, Columbus 43210-1240, USA."
            },
            {
                "name": "Romola R. Lakshmanan",
                "org": ""
            },
            {
                "name": "Matthew D. Beal",
                "org": ""
            },
            {
                "name": "Gregory A. Otterson",
                "org": ""
            }
        ],
        "venue": "Cancer research",
        "year": 2001
    },
    "QGwEIjo3": {
        "id": "QGwEIjo3",
        "title": "Novel link between E2F1 and Smac/DIABLO: proapoptotic Smac/DIABLO is transcriptionally upregulated by E2F1.",
        "abstract": "Deregulated expression of E2F1 not only promotes S-phase entry but also induces apoptosis. Although it has been well documented that E2F1 is able to induce p53-dependent apoptosis via raising ARF activity, the mechanism by which E2F induces p53-independent apoptosis remains unclear. Here we report that E2F1 can directly bind to and activate the promoter of Smac/DIABLO, a mitochondrial proapoptotic gene, through the E2F1-binding sites BS2 (-542 approximately -535 bp) and BS3 (-200 approximately -193 bp). BS2 and BS3 appear to be utilized in combination rather than singly by E2F1 in activation of Smac/DIABLO. Activation of BS2 and BS3 are E2F1-specific, since neither E2F2 nor E2F3 is able to activate BS2 or BS3. Using the H1299 ER-E2F1 cell line where E2F1 activity can be conditionally induced, E2F1 has been shown to upregulate the Smac/DIABLO expression at both mRNA and protein levels upon 4-hydroxytamoxifen treatment, resulting in an enhanced mitochondria-mediated apoptosis. Reversely, reducing the Smac/DIABLO expression by RNA interference significantly diminishes apoptosis induced by E2F1. These results may suggest a novel mechanism by which E2F1 promotes p53-independent apoptosis through directly regulating its downstream mitochondrial apoptosis-inducing factors, such as Smac/DIABLO.",
        "keywords": [
            "up regulation",
            "binding sites",
            "rna interference",
            "cell line",
            "apoptosis",
            "apoptosis inducing factor",
            "binding site"
        ],
        "authors": [
            {
                "name": "Wei Xie",
                "org": ""
            },
            {
                "name": "Peng Jiang",
                "org": ""
            },
            {
                "name": "Lin Miao",
                "org": ""
            },
            {
                "name": "Ying Zhao",
                "org": ""
            },
            {
                "name": "Zhai Zhimin",
                "org": ""
            },
            {
                "name": "Li Qing",
                "org": ""
            },
            {
                "name": "Wei-guo Zhu",
                "org": ""
            },
            {
                "name": "Mian Wu",
                "org": ""
            }
        ],
        "venue": "Nucleic acids research",
        "year": 2006
    },
    "8WrEwpR8": {
        "id": "8WrEwpR8",
        "title": "Acetylation of p53 at Lysine 373/382 by the Histone Deacetylase Inhibitor Depsipeptide Induces Expression of p21Waf1/Cip1",
        "abstract": "",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Ying Zhao",
                "org": ""
            },
            {
                "name": "Shaoli Lu",
                "org": ""
            },
            {
                "name": "Lipeng Wu",
                "org": ""
            },
            {
                "name": "Guolin Chai",
                "org": ""
            },
            {
                "name": "Haiying Wang",
                "org": ""
            },
            {
                "name": "Yingqi Chen",
                "org": ""
            },
            {
                "name": "Jia Sun",
                "org": ""
            },
            {
                "name": "Yu Yu",
                "org": ""
            },
            {
                "name": "Wen Zhou",
                "org": ""
            },
            {
                "name": "Quanhui Zheng",
                "org": ""
            },
            {
                "name": "Mian Wu",
                "org": ""
            },
            {
                "name": "Gregory A. Otterson",
                "org": ""
            },
            {
                "name": "Wei-Guo Zhu",
                "org": ""
            }
        ],
        "venue": "Molecular and Cellular Biology",
        "year": 2006
    },
    "qgN4ohEQ": {
        "id": "qgN4ohEQ",
        "title": "Angiotensin II reduces cardiac AdipoR1 expression through AT1 receptor/ROS/ERK1/2/c-Myc pathway.",
        "abstract": "Adiponectin, an abundant adipose tissue-derived protein, exerts protective effect against cardiovascular disease. Adiponectin receptors (AdipoR1 and AdipoR2) mediate the beneficial effects of adiponectin on the cardiovascular system. However, the alteration of AdipoRs in cardiac remodeling is not fully elucidated. Here, we investigated the effect of angiotensin II (AngII) on cardiac AdipoRs expression and explored the possible molecular mechanism. AngII infusion into rats induced cardiac hypertrophy, reduced AdipoR1 but not AdipoR2 expression, and attenuated the phosphorylations of adenosine monophosphate-activated protein kinase and acetyl coenzyme A carboxylase, and those effects were all reversed by losartan, an AngII type 1 (AT1) receptor blocker. AngII reduced expression of AdipoR1 mRNA and protein in cultured neonatal rat cardiomyocytes, which was abolished by losartan, but not by PD123319, an AT2 receptor antagonist. The antioxidants including reactive oxygen species (ROS) scavenger NAC, NADPH oxidase inhibitor apocynin, Nox2 inhibitor peptide gp91 ds-tat, and mitochondrial electron transport chain complex I inhibitor rotenone attenuated AngII-induced production of ROS and phosphorylation of extracellular signal-regulated kinase (ERK) 1/2. AngII-reduced AdipoR1 expression was reversed by pretreatment with NAC, apocynin, gp91 ds-tat, rotenone, and an ERK1/2 inhibitor PD98059. Chromatin immunoprecipitation assay demonstrated that AngII provoked the recruitment of c-Myc onto the promoter region of AdipoR1, which was attenuated by PD98059. Moreover, AngII-induced DNA binding activity of c-Myc was inhibited by losartan, NAC, apocynin, gp91 ds-tat, rotenone, and PD98059. c-Myc small interfering RNA abolished the inhibitory effect of AngII on AdipoR1 expression. Our results suggest that AngII inhibits cardiac AdipoR1 expression in vivo and in vitro and AT1 receptor/ROS/ERK1/2/c-Myc pathway is required for the downregulation of AdipoR1 induced by AngII.",
        "keywords": [
            "gene expression regulation",
            "adipose tissue",
            "enzyme activation",
            "mitochondria",
            "heart",
            "reactive oxygen species",
            "phosphorylation",
            "adenylate kinase"
        ],
        "authors": [
            {
                "name": "Li Li",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Zhi-Guo Zhang",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Hong Lei",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Cheng Wang",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Li-Peng Wu",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Jin-Yu Wang",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Feng-Ying Fu",
                "org": "Ministry of Health of People's Republic of China(Ministry of Health,Ministry of Public Health),Beijing,China"
            },
            {
                "name": "Wei-Guo Zhu",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Li-Ling Wu",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            }
        ],
        "venue": "PloS one",
        "year": 2013
    },
    "DmannxeV": {
        "id": "DmannxeV",
        "title": "Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).",
        "abstract": "Numerous studies indicate that Sirtuin 1 (SIRT1), a mammalian nicotinamide adenine dinucleotide (NAD(+))-dependent histone deacetylase (HDAC), plays a crucial role in p53-mediated stress responses by deacetylating p53. Nevertheless, the acetylation levels of p53 are dramatically increased upon DNA damage, and it is not well understood how the SIRT1-p53 interaction is regulated during the stress responses. Here, we identified Set7/9 as a unique regulator of SIRT1. SIRT1 interacts with Set7/9 both in vitro and in vivo. In response to DNA damage in human cells, the interaction between Set7/9 and SIRT1 is significantly enhanced and coincident with an increase in p53 acetylation levels. Importantly, the interaction of SIRT1 and p53 is strongly suppressed in the presence of Set7/9. Consequently, SIRT1-mediated deacetylation of p53 is abrogated by Set7/9, and p53-mediated transactivation is increased during the DNA damage response. Of note, whereas SIRT1 can be methylated at multiple sites within its N terminus by Set7/9, a methylation-defective mutant of SIRT1 still retains its ability to inhibit p53 activity. Taken together, our results reveal that Set7/9 is a critical regulator of the SIRT1-p53 interaction and suggest that Set7/9 can modulate p53 function indirectly in addition to acting through a methylation-dependent mechanism.",
        "keywords": [
            "p21waf1/cip1",
            "posttranslational modifications",
            "tumor suppression",
            "methylation",
            "methyltransferases",
            "protein binding",
            "cell line",
            "acetylation"
        ],
        "authors": [
            {
                "name": "Xiangyu Liu",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Donglai Wang",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Ying Zhao",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Bo Tu",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Zhixing Zheng",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Lina Wang",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Haiying Wang",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            },
            {
                "name": "Wei Gu",
                "org": "Columbia University, College of Physicians and Surgeons(Columbia University,Columbia University College of Physicians and Surgeons),New York,United States"
            },
            {
                "name": "Robert G Roeder",
                "org": "Rockefeller University(Rockefeller University,The Rockefeller University,Rockefeller Univ.),New York,United States"
            },
            {
                "name": "Wei-Guo Zhu",
                "org": "Peking University Health Science Center(^ Peking University Health Science Center),Beijing,China"
            }
        ],
        "venue": "Proceedings of the National Academy of Sciences of the United States of America",
        "year": 2011
    },
    "H32yRBNu": {
        "id": "H32yRBNu",
        "title": "Increased expression of unmethylated CDKN2D by 5-aza-2\u2032-deoxycytidine in human lung cancer cells",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Zhu W G",
                "org": "Division of Hematology/Oncology, Department of Internal Medicine, The Ohio State University-Comprehensive Cancer Center, Columbus, OH 43210, USA."
            },
            {
                "name": "Dai Z",
                "org": ""
            },
            {
                "name": "Ding H",
                "org": ""
            },
            {
                "name": "Srinivasan K",
                "org": ""
            },
            {
                "name": "Hall J",
                "org": ""
            },
            {
                "name": "Duan W",
                "org": ""
            },
            {
                "name": "Villalona-Calero M A",
                "org": ""
            },
            {
                "name": "Plass C",
                "org": ""
            },
            {
                "name": "Otterson G A",
                "org": ""
            }
        ],
        "venue": "Oncogene",
        "year": 2001
    },
    "1UucikRs": {
        "id": "1UucikRs",
        "title": "Effect of protease inhibitors on apoptosis induced by X-ray",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weiguo zhu",
                "org": ""
            },
            {
                "name": "shigetoshi antoku",
                "org": ""
            }
        ],
        "venue": "Journal of Radiation Research",
        "year": 1995
    },
    "i4PGtrrK": {
        "id": "i4PGtrrK",
        "title": "Methylation of Adjacent CpG Sites Affects Sp1/Sp3 Binding and Activity in the p21Cip1 Promoter",
        "abstract": "DNA methylation in the promoter of certain genes is associated with transcriptional silencing. Methylation affects gene expression directly by interfering with transcription factor binding and/or indirectly by recruiting histone deacetylases through methyl-DNA-binding proteins. In this study, we demonstrate that the human lung cancer cell line H719 lacks p53-dependent and -independent p21Cip1 expression. p53 response to treatment with gamma irradiation or etoposide is lost due to a mutation at codon 242 of p53 (C3W). Treatment with depsipeptide, an inhibitor of histone deacetylase, was unable to induce p53-independent p21Cip1 expression because the promoter of p21Cip1 in these cells is hypermethylated. By analyzing luciferase activity of transfected p21Cip1 promoter vectors, we demonstrate that depsipeptide functions on Sp1-binding sites to induce p21Cip1 expression. We hypothesize that hypermethylation may interfere with Sp1/Sp3 binding. By using an electro- phoretic mobility shift assay, we show that, although methylation within the consensus Sp1-binding site did not reduce Sp1/Sp3 binding, methylation outside of the consensus Sp1 element induced a significant decrease in Sp1/Sp3 binding. Depsipeptide induced p21Cip1 expression was reconstituted when cells were pretreated with 5-aza-2-deoxycytidine. Our data suggest, for the first time, that hypermethylation around the consensus Sp1-binding sites may directly reduce Sp1/Sp3 binding, therefore leading to a reduced p21Cip1 expression in response to depsipeptide treatment.",
        "keywords": [
            "cell line",
            "polymerase chain reaction",
            "gamma irradiation",
            "depsipeptides",
            "binding sites",
            "cyclins",
            "protein binding",
            "dna methylation",
            "binding site",
            "transfection",
            "codon",
            "flow cytometry",
            "dna binding protein",
            "gene expression",
            "mutation",
            "cpg islands",
            "methylation"
        ],
        "authors": [
            {
                "name": "Wei-Guo Zhu",
                "org": ""
            },
            {
                "name": "Kanur Srinivasan",
                "org": ""
            },
            {
                "name": "Zunyan Dai",
                "org": ""
            },
            {
                "name": "Wenrui Duan",
                "org": ""
            },
            {
                "name": "Lawrence J. Druhan",
                "org": ""
            },
            {
                "name": "Haiming Ding",
                "org": ""
            },
            {
                "name": "Lisa Yee",
                "org": ""
            },
            {
                "name": "Miguel A. Villalona-Calero",
                "org": ""
            },
            {
                "name": "Christoph Plass",
                "org": ""
            },
            {
                "name": "Gregory A. Otterson",
                "org": ""
            }
        ],
        "venue": "Molecular and Cellular Biology",
        "year": 2003
    },
    "kPkGWukN": {
        "id": "kPkGWukN",
        "title": "Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53.",
        "abstract": "Although the recently identified Pirh2 protein is known as a p53-induced ubiquitin-protein E3 ligase, which negatively regulates p53, the detailed mechanism underlying the regulation of Pirh2 remains largely unknown. Here, we demonstrate that while Pirh2 is mostly detected in the phosphorylated form in normal tissues, it is predominantly present in the unphosphorylated form in majority of tumor cell lines and tissues examined. Phosphorylated Pirh2 is far more unstable than its unphosphorylated form. We further identified that Calmodulin-dependent kinase II (CaMK II) phosphorylates Pirh2 on residues Thr-154 and Ser-155. Phosphorylation of Pirh2 appears to be regulated through cell cycle-dependent mechanism. CaMK II-mediated Pirh2 phosphorylation abrogates its E3 ligase activity toward p53. Together, our data suggest that phosphorylation of Pirh2 may act as a fine-tuning to maintain the balance of p53-Pirh2 autoregulatory feedback loop, which facilitates the tight regulation of p53 stability and tumor suppression.",
        "keywords": [
            "p53",
            "camk ii",
            "phosphorylation",
            "pirh2",
            "ubiquitination",
            "gene expression regulation",
            "protein binding",
            "amino acid sequence",
            "cell cycle",
            "conserved sequence",
            "calmodulin",
            "ubiquitin",
            "sequence alignment"
        ],
        "authors": [
            {
                "name": "Shanshan Duan",
                "org": ""
            },
            {
                "name": "Zhan Yao",
                "org": ""
            },
            {
                "name": "Dezhi Hou",
                "org": ""
            },
            {
                "name": "Zhengsheng Wu",
                "org": ""
            },
            {
                "name": "Wei-Guo Zhu",
                "org": ""
            },
            {
                "name": "Mian Wu",
                "org": ""
            }
        ],
        "venue": "The EMBO journal",
        "year": 2007
    },
    "HL9e13mV": {
        "id": "HL9e13mV",
        "title": "Increased expression of unmethylated CDKN2D by 5-aza-2\u2032-deoxycytidine in human lung cancer cells",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "gregory a otterson",
                "org": ""
            },
            {
                "name": "christoph plass",
                "org": ""
            },
            {
                "name": "kanur srinivasan",
                "org": ""
            },
            {
                "name": "miguel a villalonacalero",
                "org": ""
            },
            {
                "name": "haiming ding",
                "org": ""
            },
            {
                "name": "julia hall",
                "org": ""
            },
            {
                "name": "zunyan dai",
                "org": ""
            },
            {
                "name": "wenrui duan",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Oncogene",
        "year": 2001
    },
    "XQIQWzPE": {
        "id": "XQIQWzPE",
        "title": "ULK1 phosphorylates Mad1 to regulate spindle assembly checkpoint.",
        "abstract": "The spindle assembly checkpoint (SAC) ensures the fidelity of chromosome segregation during mitosis. Here, we show that ULK1, a serine/threonine kinase that plays a key role in initiation of autophagy, also has an important function in the activation of SAC. ULK1 phosphorylates the SAC protein Mad1 at Ser546 to recruit Mad1 to kinetochores. Furthermore, Rod/ZW10/Zwilch (RZZ) complex may serve as a receptor for phos-Ser546-Mad1 at kinetochore, since phosphorylation of Mad1 by ULK1 strengthens the interaction between Mad1 and RZZ complex. In addition, deletion of ULK1 increases chromosome instability and cytotoxicity of paclitaxel, resulting in significant impairment of cancer cell growth. These findings highlight the role of ULK1 as a protein kinase controlling the fidelity of chromosome segregation and cell-cycle progression.",
        "keywords": "",
        "authors": [
            {
                "name": "Fengjie Yuan",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China."
            },
            {
                "name": "Ximin Jin",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China."
            },
            {
                "name": "Dan Li",
                "org": "Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China."
            },
            {
                "name": "Yuanshuai Song",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China."
            },
            {
                "name": "Nan Zhang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China."
            },
            {
                "name": "Xin Yang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China."
            },
            {
                "name": "Lina Wang",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China."
            },
            {
                "name": "Wei-Guo Zhu",
                "org": "School of Medicine, Shenzhen University, Shenzhen 518060, China."
            },
            {
                "name": "Chan Tian",
                "org": "Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China."
            },
            {
                "name": "Ying Zhao",
                "org": "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China."
            }
        ],
        "venue": "Nucleic acids research",
        "year": 2019
    },
    "ILqC0ofd": {
        "id": "ILqC0ofd",
        "title": "Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity.",
        "abstract": "Autophagy is characterized by the sequestration of bulk cytoplasm, including damaged proteins and organelles, and delivery of the cargo to lysosomes for degradation. Although the autophagic pathway is also linked to tumour suppression activity, the mechanism is not yet clear. Here we report that cytosolic FoxO1, a forkhead O family protein, is a mediator of autophagy. Endogenous FoxO1 was required for autophagy in human cancer cell lines in response to oxidative stress or serum starvation, but this process was independent of the transcriptional activity of FoxO1. In response to stress, FoxO1 was acetylated by dissociation from sirtuin-2 (SIRT2), a NAD(+)-dependent histone deacetylase, and the acetylated FoxO1 bound to Atg7, an E1-like protein, to influence the autophagic process leading to cell death. This FoxO1-modulated cell death is associated with tumour suppressor activity in human colon tumours and a xenograft mouse model. Our finding links the anti-neoplastic activity of FoxO1 and the process of autophagy.",
        "keywords": [
            "molecular biology",
            "genetics",
            "cancer",
            "signal transduction",
            "cell biology",
            "polarity",
            "adhesion",
            "ageing",
            "apoptosis",
            "biology",
            "migration",
            "dna damage",
            "transcription",
            "nature",
            "cell cycle",
            "zebrafish",
            "cytoskeleton",
            "biophysics",
            "signalling",
            "stem cells",
            "chromatin",
            "cell",
            "cell line",
            "biochemistry",
            "cell death",
            "microrna"
        ],
        "authors": [
            {
                "name": "Ying Zhao",
                "org": "american society for biochemistry and molecular biology"
            },
            {
                "name": "Jing Yang",
                "org": "american society for biochemistry and molecular biology"
            },
            {
                "name": "Wenjuan Liao",
                "org": "american society for biochemistry and molecular biology"
            },
            {
                "name": "Xiangyu Liu",
                "org": "american society for biochemistry and molecular biology"
            },
            {
                "name": "Hui Zhang",
                "org": "american society for biochemistry and molecular biology"
            },
            {
                "name": "Shan Wang",
                "org": "peking university health science center"
            },
            {
                "name": "Donglai Wang",
                "org": "american society for biochemistry and molecular biology"
            },
            {
                "name": "Jingnan Feng",
                "org": "american society for biochemistry and molecular biology"
            },
            {
                "name": "Li Yu",
                "org": "tsinghua university"
            },
            {
                "name": "Wei-Guo Zhu",
                "org": "american society for biochemistry and molecular biology"
            }
        ],
        "venue": "Nature cell biology",
        "year": 2010
    },
    "a8l5YpTF": {
        "id": "a8l5YpTF",
        "title": "HDAC inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "lipeng wu",
                "org": ""
            },
            {
                "name": "xi wang",
                "org": ""
            },
            {
                "name": "lian li",
                "org": ""
            },
            {
                "name": "ying zhao",
                "org": ""
            },
            {
                "name": "shaoli lu",
                "org": ""
            },
            {
                "name": "yu yu",
                "org": ""
            },
            {
                "name": "wen zhou",
                "org": ""
            },
            {
                "name": "xiangyu liu",
                "org": ""
            },
            {
                "name": "jing yang",
                "org": ""
            },
            {
                "name": "zhixin zheng",
                "org": ""
            },
            {
                "name": "hui zhang",
                "org": ""
            },
            {
                "name": "jingnan feng",
                "org": ""
            },
            {
                "name": "yang yang",
                "org": ""
            },
            {
                "name": "haiying wang",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            }
        ],
        "venue": "Molecular and Cellular Biology",
        "year": 2008
    },
    "igNLjo5l": {
        "id": "igNLjo5l",
        "title": "DNA Methylation in the Exon 1 Region and Complex Regulation of Twist1 Expression in Gastric Cancer Cells",
        "abstract": "Twist1 overexpression is frequently observed in various cancers including gastric cancer (GC). Although DNA methylation of the Twist1 gene has been reported in cancer cells, the mechanisms underlying transcriptional activation remain uncertain. In this study, we first examined epigenetic alterations of the Twist1 using Twist1 transcription-positive and -negative cell lines that are derived from our established diffuse-type GC mouse model. Treatment with a DNA demethylation agent 5-aza-dC re-activated Twist1 expression in Twist1 expression-negative GC cells. According to methylation-specific PCR and bisulfite sequencing analysis, methylation at the CpG-rich region within Twist1 coding exon 1, rather than its promoter region, was tightly linked to transcriptional silencing of the Twist1 expression in mouse GC cells. Chromatin immunoprecipitation assays revealed that active histone mark H3K4me3 was enriched in Twist1 expression-positive cells, and inactive histone mark H3K9me3 was enriched in Twist1 expression-negative cells. The expression levels of Suv39h1 and Suv39h2, histone methyltransferases for H3K9me3, were inversely correlated with Twist1 expression, and knockdown of Suv39h1 or Suv39h2 induced Twist1 expression. Moreover, Sp1 transcription factor bound to the exon 1 CpG-rich region in Twist1 expression-positive cell lines, and Twist1 expression was diminished by mithramycin, which that interferes with Sp1 binding to CpG-rich regulatory sequences. Our studies suggested that the Twist1 transcription in GC cells might be regulated through potential cooperation of DNA methylation, histone modification in complex with Sp1 binding to CpG-rich regions within the exon 1 region.",
        "keywords": [
            "medicine",
            "physics",
            "biology",
            "chemistry",
            "gene expression",
            "polymerase chain reaction",
            "dna methylation",
            "histones",
            "engineering"
        ],
        "authors": [
            {
                "name": "ayuna sakamoto",
                "org": "tokyo medical and dental university"
            },
            {
                "name": "yoshimitsu akiyama",
                "org": "tokyo medical and dental university"
            },
            {
                "name": "shu shimada",
                "org": "tokyo medical and dental university"
            },
            {
                "name": "weiguo zhu",
                "org": "american society for biochemistry and molecular biology"
            },
            {
                "name": "yasuhito yuasa",
                "org": "tokyo medical and dental university"
            },
            {
                "name": "shinji tanaka",
                "org": "tokyo medical and dental university"
            }
        ],
        "venue": "PLOS ONE",
        "year": 2015
    },
    "TJSnnDdm": {
        "id": "TJSnnDdm",
        "title": "SIB-IMRT for Neck and Upper Thoracic Esophageal Carcinoma",
        "abstract": "Objective To implement simultaneous integrated boost intensity-modulated radiotherapy(SIB-IMRT)plans for curing neck and upper thoracic esophageal carcinoma,and investigate the acute toxicity and early response.Methods SIB-IMRT plans were designed for 27 patients with neck and upper thoracic carcinoma.Two target volumes were predefined:PTV1,the target volume of primary lesion,which was given 66 Gy(2.2\u00d730 fractions);PTV2,the target volumes of electively treated lesion,which was given 54 Gy(1.8\u00d730 fractions).The plans were with coplanar beams.Results All the patients completed the treatment within 6 weeks.Only one with grade 3 acute bronchitis was observed.The immediate responses were CR 85.2%(23/27),PR 14.8%(4/27),overall response was 100% in esophageal lesion and CR 70.6%(12/17),PR 29.4%(5/17)in lymph node lesion.Conclusion Five coplanar beams IMRT can produce desirable dose distribution for SIB treatment of neck and upper thoracic esophageal carcinoma,especially the one with positive lymph node.Immediate response is satisfying and acute toxicity is not severe.But long-term effect and late toxicity need to be further studied.",
        "keywords": [
            "Curative effect",
            "Intensity-modulated radimion therapy",
            "Esophageal neoplasms"
        ],
        "authors": [
            {
                "name": "YU Chang-hua",
                "org": " Department of Radiation Oncology,Huai'an First People Hospital,Huai'an ,China"
            },
            {
                "name": "WANG Wan-wei",
                "org": " Department of Radiation Oncology,Huai'an First People Hospital,Huai'an ,China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": " Department of Radiation Oncology,Huai'an First People Hospital,Huai'an ,China"
            },
            {
                "name": "HAN Ji-hua",
                "org": " Department of Radiation Oncology,Huai'an First People Hospital,Huai'an ,China"
            },
            {
                "name": "LI Tao",
                "org": " Department of Radiation Oncology,Huai'an First People Hospital,Huai'an ,China"
            },
            {
                "name": "TAO Guang-zhou",
                "org": " Department of Radiation Oncology,Huai'an First People Hospital,Huai'an ,China"
            }
        ],
        "venue": "Cancer Research on Prevention and Treatment",
        "year": 2010
    },
    "5G8IUqN6": {
        "id": "5G8IUqN6",
        "title": "Radiotheraphy with concurrent chemotherapy for treatment of local advanced cervical cancer",
        "abstract": "Objective To evaluate the long-term effect of radiotherapy combined with concurrent chemotherapy for the treatment of advanced cervical cancer and its toxicity.Methods Between Feb 2002 and Aug 2003,120 cases of advanced cervical cancer of First Hospital of Huai An were randomized into two groups:Radiotheraphy alone group(R group,n=60);Concurrent chemoradiotherapy group(CR group,n=60),40 mg of cisplatin per square meter of body-surface area per week for six weeks. Radiotherapy was administered to the whole pelvic region in 20 fractions totaling 40 Gy,followed one to three weeks later or simultaneous by intracavitary brachytherapy. The total dose delivered to point A (a reference location 2 cm lateral and 2 cm superior to the cervical os) was 82 Gy,the total dose delivered to point B (the pelvic wall) was 54.0 Gy in patients with stage \u2161b disease and 60.0 Gy in patients with stage \u2162 or \u2163a disease. Results All patients completed the treatment course. The complete response rates in CR and R groups were 83.3% and 53.3%(\u03c72=12.48,P=0.000); and disease free survival rates in CR and R groups were 81.7%,65%,55%and 70%,45%,33.3%,(\u03c72=5.96,P=0.015),and overall survival rates in CR and R groups were 83.3%,71.6%,66.7%and 76.7%,53.3%,45%( \u03c72=5.37,P=0.021). Acute toxicity in concurrent chemoradiotherapy group was higher than radiotherapy alone group.Conclusion Regimens of radiotherapy and chemotherapy with cisplatin improve the rates of overall survival and disease-free survival among women with locally advanced cervical cancer.",
        "keywords": [
            "radiotherapy",
            "cervical neoplasm",
            "chemotherapy"
        ],
        "authors": [
            {
                "name": "ZHU Wei-guo",
                "org": ".Department of Radiation Oncology,First Hospital of HuaiAn,Nanjing Medical university,HuaiAn ,China"
            },
            {
                "name": "LI Tao",
                "org": ".Department of Radiation Oncology,First Hospital of HuaiAn,Nanjing Medical university,HuaiAn ,China"
            },
            {
                "name": "HAN Ji-hua",
                "org": ".Department of Radiation Oncology,First Hospital of HuaiAn,Nanjing Medical university,HuaiAn ,China"
            },
            {
                "name": "YU Chang-hua",
                "org": ".Department of Radiation Oncology,First Hospital of HuaiAn,Nanjing Medical university,HuaiAn ,China"
            },
            {
                "name": "ZHOU Xi-lei",
                "org": ".Department of Radiation Oncology,First Hospital of HuaiAn,Nanjing Medical university,HuaiAn ,China"
            },
            {
                "name": "ZHANG Xiao-ye",
                "org": ".Department of Radiation Oncology,First Hospital of HuaiAn,Nanjing Medical university,HuaiAn ,China"
            }
        ],
        "venue": "Chinese Journal of Practical Gynecology and Obstetrics",
        "year": 2010
    },
    "fBcPnAsI": {
        "id": "fBcPnAsI",
        "title": "The Study of CTV-PTV Margin During the Treatment of Nasopharyngeal Carcinoma with Intensity Modulation Radiation Therapy",
        "abstract": "Objective To investigate the positioning errors in the treatment of nasopharyngeal carcinoma with intensity modulation radiation therapy(IMRT) by portal film and defined margins for the definition of planning target volume.Methods The positioning data of 10 patients treated with IMRT for nasopharyngeal carcinoma were analyzed.Orthogonal verification films were taken once one week.Field shape and an anatomy template consisting of contours of relevant bony structures on DRR and portal film swerve drawn and compared to obtain the positioning data,and random and systematic positioning deviations were measured.Margins for CTV-PTV were defined accounting to systematic and random positioning uncertainties.Results One hundred and twenty images were obtained from the treatment of the 10 patients.Eleven images were excluded due to poor quality that it could not used to identify two or more relevant bony structures.For each patient,the systematic and random errors for the different directions were measured respectively.The over all positioning errors showed 2.4 mm,2.3 mm,2.4 mm along the left-right,craniocaudal and anterior-posterior directions,respectively.The systematic component was 2.4 mm,2.3 mm,2.4 mm and the random positioning component was 1.4 mm,1.5 mm,1.5 mm in the left-right,craniocaudal and ventrodorsal directions,respectively.The overall mean deviation was -1.1 mm,-0.1 mm,-0.25 mm in the left-right,craniocaudal and ventrodorsal directions,respectively.26.3% of positioning with three dimensional positioning deviations greater than 3 mm but less than 4 mm,15.1% greater than 4 mm but less than 5 mm,6.5% with 5 mm or more.Unilateral positioning deviation with more than 3 mm was 17.5%,20.0% and 22.5%,in the left-right,craniocaudal and ventrodorsal directions,respectively.The 6 mm of CTV-PTV margins were feasible in all three directions.Conclusion The application of proposed recipes for CTV-PTV margins indicates that 6 mm is feasible in nasopharyngeal carcinoma radiotherapy with the immobilizing and positioning technique in our hospital.",
        "keywords": [
            "nasopharyngeal carcinoma",
            "radiotherapy",
            "positioning error"
        ],
        "authors": [
            {
                "name": "Zhang Xiaoye",
                "org": "Department of Radiation Oncology,the First Hospital of Huai'an,Nanjing Medical University,Huai'an ,China"
            },
            {
                "name": "Han Jihua",
                "org": "Department of Radiation Oncology,the First Hospital of Huai'an,Nanjing Medical University,Huai'an ,China"
            },
            {
                "name": "Zhu Weiguo",
                "org": "Department of Radiation Oncology,the First Hospital of Huai'an,Nanjing Medical University,Huai'an ,China"
            },
            {
                "name": "Zhang Yan",
                "org": "Department of Radiation Oncology,the First Hospital of Huai'an,Nanjing Medical University,Huai'an ,China"
            },
            {
                "name": "Yu Changhua",
                "org": "Department of Radiation Oncology,the First Hospital of Huai'an,Nanjing Medical University,Huai'an ,China"
            },
            {
                "name": "Li Tao",
                "org": "Department of Radiation Oncology,the First Hospital of Huai'an,Nanjing Medical University,Huai'an ,China"
            }
        ],
        "venue": "Journal of Basic and Clinical Oncology",
        "year": 2010
    },
    "9UAm7X0H": {
        "id": "9UAm7X0H",
        "title": "Application of intensity-modulated radiotherapy combined with chemotherapy for the treatment of gastric cancer patients after D1/D2 standard surgery",
        "abstract": "Objective:To evaluate the efficacy and complications of concurrent chemoradiotherapy(CCRT) for the treatment of gastric cancer patients after D1/D2 surgery.Methods: Sixty-eight untreated gastric cancer patients(T3/T4 and/or N+) were enrolled.They were first treated with surgery,and the clearing scope reached D1/D2 standards with an incisal margin of R0.The patients were randomized into two groups: CCRT group and single chemotherapy group.The CCRT group was treated according to INT 0116(Intergroup 0116).One cycle of chemotherapy consisted of 5-fluorouracil(5-FU) and tetrahydrogolic acid(LV) administered continuously.CCRT began 28 days after the first cycle of chemotherapy,and the combination of 5-FU and LV was given in the first four and last three days(corresponding to the second and third cycles of chemotherapy in the single chemotherapy group) during the CCRT period with the radiation dosage of 45Gy/25f,i.e.1.8Gy five times per week.Two cycles of the same chemotherapy were administrated one month after radiotherapy-X-ray intensity-modulated external radiation,DT 45Gy/25f.Five cycles of 5-FU and LV were applied in the single chemotherapy group.Results: One,two and three-year survival rates were 85.9%,73.4% and 67.7% in the CCRT group and 68.0%,50.0% and 44.1% in the single chemotherapy group respectively(P <0.05);and corresponding disease-free survival rates were 73.5%,64.7% and 55.8% in the CCRT group and 61.8%,38.2% and 29.4% in the single chemotherapy group respectively(P< 0.05).The major side effects were gastrointestinal reactions and neutrocytopenia.In the CCRT and single chemotherapy groups,the incidences were 73.5%(25/34) and 44.1%(15/34)(P<0.05) for grade I and II anorexia,82.35%(28/34) and 73.5%(25/34)(P>0.05) for nausea and vomiting and 70.6%(24/34) and 44.1%(15/34)(P<0.05) for neutrocytopenia.Other indices showed no significant differences.Conclusion: CCRT can increase one,two and three-year total and disease-free survival rates of gastric cancer patients(T3/T4 and/or N+) who have been treated with surgery.The major adverse reactions were grade \u2160 and \u2161 nausea and vomiting,as well as myelosuppression.CCRT is well tolerated.",
        "keywords": [
            "gastric cancer",
            "intensity modulated radiotherapy",
            "chemotherapy"
        ],
        "authors": [
            {
                "name": "LI Tao",
                "org": " Department of Radiation Oncology,Huai'an First People Hospital,Jiangsu Huai'an ,China."
            },
            {
                "name": "YU Changhua",
                "org": " Department of Radiation Oncology,Huai'an First People Hospital,Jiangsu Huai'an ,China."
            },
            {
                "name": "YU Ren",
                "org": " Department of Radiation Oncology,Huai'an First People Hospital,Jiangsu Huai'an ,China."
            },
            {
                "name": "ZHU Weiguo",
                "org": " Department of Radiation Oncology,Huai'an First People Hospital,Jiangsu Huai'an ,China."
            },
            {
                "name": "HAN Jihua",
                "org": " Department of Radiation Oncology,Huai'an First People Hospital,Jiangsu Huai'an ,China."
            }
        ],
        "venue": "Journal of Modern Oncology",
        "year": 2012
    },
    "lVgSmitH": {
        "id": "lVgSmitH",
        "title": "The effect of radiotherapy combined with Xeloda and radiotherapy alone on quality of life in old local advanced esophageal cancer patients",
        "abstract": "Objective: To study the effect of radiotherapy combined Xeloda and radiotherapy alone on quality of life(QOL) in old local advanced esophageal cancer patients.Methods:From June 2007 to June 2011,total 133 old patients with esophageal cancer were treated,64 cases with radiotherapy combined Xeloda and 69 cases with radiotherapy alone.A special table reflecting patients' QOL to evaluate patient's status,which include weight,daily activity ability,sensibility,diet,dysphagia,nausea and vomiting,and diarrhea.Results:Effective rate was 93.8% in combined group and 84.1% in radiotherapy alone group(P=0.077);and complete response was 70.3% in combined group and 43.5% in radiotherapy alone group(P=0.002).Nausea and vomiting rates were higher in combined group than those in radiotherapy alone group,the rest of indicator of QOL were similar in two groups.Conclusion:The effect of radiotherapy combined Xeloda and radiotherapy alone on QOL in local advanced old esophageal cancer patients was similar,combined therapy could increase complete response.",
        "keywords": [
            "QOL",
            "efficacy",
            "esophageal cancer",
            "Xeloda",
            "radiotherapy"
        ],
        "authors": [
            {
                "name": "Hu Shuiqing",
                "org": " Department of Radiation Oncology,Huaian NO 1 Hospital,Nanjing Medical University,Jiangsu Huaian ,China."
            },
            {
                "name": "Zhu Weiguo",
                "org": " Department of Radiation Oncology,Huaian NO 1 Hospital,Nanjing Medical University,Jiangsu Huaian ,China."
            },
            {
                "name": "Gan Yaxian",
                "org": " Department of Radiation Oncology,Huaian NO 1 Hospital,Nanjing Medical University,Jiangsu Huaian ,China."
            },
            {
                "name": "Li Tao",
                "org": " Department of Radiation Oncology,Huaian NO 1 Hospital,Nanjing Medical University,Jiangsu Huaian ,China."
            },
            {
                "name": "Yu Changhua",
                "org": " Department of Radiation Oncology,Huaian NO 1 Hospital,Nanjing Medical University,Jiangsu Huaian ,China."
            },
            {
                "name": "Ji Fuzhi",
                "org": " Department of Radiation Oncology,Huaian NO 1 Hospital,Nanjing Medical University,Jiangsu Huaian ,China."
            }
        ],
        "venue": "Journal of Modern Oncology",
        "year": 2013
    },
    "tBv4PTNx": {
        "id": "tBv4PTNx",
        "title": "Comparison of efficacy for postoperative chemotherapy and concurrent radiochemotherapy in patients with IIIA-pN2 non-small cell lung cancer: an early closed randomized controlled trial.",
        "abstract": "The efficacy of postoperative concurrent radiochemotherapy (POCRT) on IIIA-pN2 non-small cell lung cancer (NSCLC) is still unclear. The aim of this randomized controlled trial was to compare POCRT with postoperative chemotherapy (POCT) alone in terms of survival and relapse patterns.Patients with completely resected IIIA-pN2 NSCLC were randomized into POCRT or POCT groups. Chemotherapy consisted of paclitaxel (175 mg/m(2)) and cisplatin (60 mg/m(2)) administered intravenously for four cycles on day 1, 22, 43, and 64. Patients in the POCRT group received radiotherapy (50.4 Gy/28 fractions) concurrently with the first 2 cycles of chemotherapy.This study recruited 140 participants and was closed early because of slow accrual. Data were analyzed for 135 of them including 66 cases in the POCRT group and 69 cases in the POCT group. Patients were followed-up for a median period of 45 months. The POCRT group had a median survival (MS) of 40 months and a 5-year overall survival (OS) rate of 37.9%. The POCT group had a MS of 28 months and a 5-year OS rate of 27.5%. The hazard ratio for death in the POCRT group was 0.69 (95% CI: 0.457-1.044, P=0.073). We observed a disease-free survival (DFS) of 28 months and a 5-year DFS rate of 30.3% in the POCRT group. Likewise, we observed a DFS of 18 months and a 5-year DFS rate of 18.8% in the POCT group. The recurrence hazard ratio in the POCT group was 1.49 (95% CI: 1.008-2.204, P=0.041). Subgroup analysis revealed that POCRT significantly increased the OS rate of the patients with \u22652 pN2 lymph nodes (P=0.021). The POCRT group had a significantly lower local relapse (P=0.009) and distant metastasis (P=0.05) rates as compared to that of the POCT group. One case died of pyemia and 9 cases suffered from grade 3 and 4 acute radiation esophagitis. The two groups had similar and tolerable hematologic toxicities.Compared with POCT, POCRT increased both local/regional and distant DFS rate of the patients with IIIA-pN2 NSCLC, but not the OS rate. Considering the relatively small sample size of the current study, caution should be taken when adopting the conclusions.",
        "keywords": [
            "iiia-pn2",
            "non-small cell lung cancer",
            "postoperative concurrent radiochemotherapy",
            "surgery",
            "survival"
        ],
        "authors": [
            {
                "name": "Wen-yi Shen",
                "org": "Department of Radiation Oncology, People's Hospital of Lianshui County, Huai'an, PR China."
            },
            {
                "name": "Jian Ji",
                "org": "Department of Radiation Oncology, Huai'an First People's Hospital, Nanjing Medical University, PR China."
            },
            {
                "name": "Yang-song Zuo",
                "org": "Department of Radiation Oncology, People's Hospital of Lianshui County, Huai'an, PR China."
            },
            {
                "name": "Juan Pu",
                "org": "Department of Radiation Oncology, People's Hospital of Lianshui County, Huai'an, PR China."
            },
            {
                "name": "Yan-mei Xu",
                "org": "Department of Radiation Oncology, Huai'an First People's Hospital, Nanjing Medical University, PR China."
            },
            {
                "name": "Cheng-dong Zong",
                "org": "Department of Radiation Oncology, Oncology Hospital of Huai'an, PR China."
            },
            {
                "name": "Guang-zhou Tao",
                "org": "Department of Radiation Oncology, Huai'an First People's Hospital, Nanjing Medical University, PR China."
            },
            {
                "name": "Xiao-fei Chen",
                "org": "Department of Radiation Oncology, Huai'an First People's Hospital, Nanjing Medical University, PR China."
            },
            {
                "name": "Fu-zhi Ji",
                "org": "Department of Radiation Oncology, Huai'an First People's Hospital, Nanjing Medical University, PR China."
            },
            {
                "name": "Xi-lei Zhou",
                "org": "Department of Radiation Oncology, Huai'an First People's Hospital, Nanjing Medical University, PR China."
            },
            {
                "name": "Ji-hua Han",
                "org": "Department of Radiation Oncology, Huai'an First People's Hospital, Nanjing Medical University, PR China."
            },
            {
                "name": "Cheng-shi Wang",
                "org": "Department of Radiation Oncology, People's Hospital of Lianshui County, Huai'an, PR China."
            },
            {
                "name": "Jiang-guo Yi",
                "org": "Department of Radiation Oncology, Oncology Hospital of Huai'an, PR China."
            },
            {
                "name": "Xi-long Su",
                "org": "Department of Radiation Oncology, Huai'an No. 2 People's Hospital, PR China."
            },
            {
                "name": "Wei-guo Zhu",
                "org": "Department of Radiation Oncology, Huai'an First People's Hospital, Nanjing Medical University, PR China."
            }
        ],
        "venue": "Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology",
        "year": 2014
    },
    "sefZnIsV": {
        "id": "sefZnIsV",
        "title": "The feasibility of the simultaneous integrated boost for malignant gliomas with intensity-modulated radiotherapy",
        "abstract": "Objective To investigate feasibility of the simultaneous integrated boost for malignant gliomas with intensity-modulated radiotherapy(SIB-IMRT).Methods Six patients with malignant gliomas were treated with SIB-IMRT.Results There was no patients delayed by acute radiation toxicity.The tumor recurred regionally in five of the six patients.The glioblastoma(GBM) in four patients recurred at 5.4,4.0, 6.4 and 7.0 months after radiotherapy.Three patients with GBM died at 5.4,8.4 and 16 months after radiotherapy,respectively.Conclusions It is effective to treat glioma with SIB-IMRT.",
        "keywords": [
            "Intensity-modulated radiotherapy",
            "Malignant glioma",
            "Simultaneous integrated boost"
        ],
        "authors": [
            {
                "name": "ZHU Wei-guo",
                "org": "Department of Radiation Oncology,The First Hospital of Huai'an affiliated to Nanjing Medical University,Huai'an ,Jiangsu,China"
            },
            {
                "name": "HAN Ji-hua",
                "org": "Department of Radiation Oncology,The First Hospital of Huai'an affiliated to Nanjing Medical University,Huai'an ,Jiangsu,China"
            },
            {
                "name": "LI Tao",
                "org": "Department of Radiation Oncology,The First Hospital of Huai'an affiliated to Nanjing Medical University,Huai'an ,Jiangsu,China"
            }
        ],
        "venue": "Medical Journal of West China",
        "year": 2009
    },
    "RdkghTBw": {
        "id": "RdkghTBw",
        "title": "Prospective Clinical Comparison of Concurrent Chemoradiotherapy or Radiotherapy Alone for Patients with N1 Esophageal Carcinoma",
        "abstract": "Objective To compare the survival and toxicities of concurrent chemoradiotherapy or radiotherapy alone in patients with N1 esophageal carcinoma. Methods From August 2002 to August 2005, 130 eligible patients with N1 esophageal carcinoma were randomly divided into the following groups: sixty-five patients for concurrent chemoradiotherapy group, sixty-five patients for radiotherapy alone. The schedules of radiotherapy were the same, with 3-DCRT with conventional fractionation , total dose 64\uff5e66Gy. The regiment of chemotherapy were all consisted of NDP and 5-Fu, 4 cycles . Results The survival rates at 1-\u30012-and 3-years were 72.3%,55.3% and 40% in the concurrent chemoradiotherapy group,while the numbers were 75.3%,38.5% and 18.5% in the radiotherapy alone group (P =0.007).The patients in concurrent chemoradiotherapy group who completed 1~2 cycles and 3~ 4 cycles the survival rates at 1-,2-and 3-years were 70%,53.3%,30% and 74.2%,57.1%,48.6% (P=0.128),respectively; 3-year distant metastasis rates were 10.7% in concurrent chemoradiotherapy group, and 16.9% in radiotherapy alone group (P=0.31), respectively.Acute toxicity in concurrent chemoradiotherapy group was higher than radiotherapy alone group,and later toxicity were similar in two group.Conclusion Concurrent chemoradiotherapy increased severity acute toxicity, and could increase survival rate compared with radiotherapy alone in patient with N1 esophageal carcinoma, and the patients who completed 3~4 cycles seemed better than those completed 1~2 cycles.",
        "keywords": [
            "Lymph node metastasis",
            "Chemotherapy",
            "Radiotherapy",
            "Esophageal neoplasm"
        ],
        "authors": [
            {
                "name": "ZHU Wei-guo",
                "org": " Department of Radiation Oncology,First Hospital of Huai\u2019an, Nanjing Medical University,Huai\u2019an ,China"
            },
            {
                "name": "YU Chang-hua",
                "org": " Department of Radiation Oncology,First Hospital of Huai\u2019an, Nanjing Medical University,Huai\u2019an ,China"
            },
            {
                "name": "ZHOU Xi-lei",
                "org": " Department of Radiation Oncology,First Hospital of Huai\u2019an, Nanjing Medical University,Huai\u2019an ,China"
            },
            {
                "name": "LI Tao",
                "org": " Department of Radiation Oncology,First Hospital of Huai\u2019an, Nanjing Medical University,Huai\u2019an ,China"
            },
            {
                "name": "HAN Ji-hua",
                "org": " Department of Radiation Oncology,First Hospital of Huai\u2019an, Nanjing Medical University,Huai\u2019an ,China"
            },
            {
                "name": "ZHANG Xiao-ye",
                "org": " Department of Radiation Oncology,First Hospital of Huai\u2019an, Nanjing Medical University,Huai\u2019an ,China"
            }
        ],
        "venue": "Cancer Research on Prevention and Treatment",
        "year": 2010
    },
    "MN7M6wxq": {
        "id": "MN7M6wxq",
        "title": "Concurrent chemoradiotherapy for postoperative regional recurrence in esophageal carcinoma",
        "abstract": "Objective:To study the effect of concurrent chemoradiotherapy with PF regiment vs radiotherapy alone for regional recurrnce in esophageal carcinoma after radical surgery and its prognostics factor.Methods:From January 2003 to September 2005,90 eligible patients with postoperative squamous cell carcinoma of esophagus were randomized into the study.Forty-five patients were given three dimensional conformal radiotherapy alone(CF group),who received conventional fractionation during radiotherapy course.The dose was 50Gy/25d for PTV,boost for GTV to a total dose of 64 Gy/46d.Forty-five patients enrolled to the concurrent chemoradiotherapy group(CMF group),who received two cycles of chemotherapy during radiotherapy followed by additional two cycles chemotherapy.The regimen of chemotherapy consisted of cisplantin 20mg/m2/d and fluorouracil(5-FU) 500mg/m2/d from day 1 to day 4.The interval between each cycle was 4 weeks.Results:The median survival was 24.0 months in CMF group,17.5 months in CF.In CF group,the survival rates at 1,2,3 years were 66.7%,31.1% and 15.6%,respectively,whereas they were 68.9%,49.9% and 35.6%in CMF group(P=0.03).The complete response rates were 53.3% in CMF group,and 20 in CF group(P=0.001),respectively.Three-year distant metastasis rates were 26.7% in CMF group,and 40% in CF group(P=0.18).Metastatic number,whether or not chemotherapy and tumor size were independent prognostic factors.The acute toxicities were higher in CMF group than CF group.Conclusion:Concurrent chemoradiotherapy may decrease distant metastasis rate and increase complete response rate and overall survival compared with CF alone,but acute toxicities were high.",
        "keywords": [
            "recurrence",
            "esophageal neoplasms",
            "concurrent chemoradiotherapy",
            "prognosis"
        ],
        "authors": [
            {
                "name": "HAN Ji-hua",
                "org": " Department of Radiation Oncology,Huai'an First Affiliated Hospital,Nanjing Medical University,Huai'an Jiangsu ,China."
            },
            {
                "name": "YU Chang-hua",
                "org": " Department of Radiation Oncology,Huai'an First Affiliated Hospital,Nanjing Medical University,Huai'an Jiangsu ,China."
            },
            {
                "name": "ZHU Wei-guo",
                "org": " Department of Radiation Oncology,Huai'an First Affiliated Hospital,Nanjing Medical University,Huai'an Jiangsu ,China."
            },
            {
                "name": "LI Tao",
                "org": " Department of Radiation Oncology,Huai'an First Affiliated Hospital,Nanjing Medical University,Huai'an Jiangsu ,China."
            },
            {
                "name": "ZHOU Xi-lei",
                "org": " Department of Radiation Oncology,Huai'an First Affiliated Hospital,Nanjing Medical University,Huai'an Jiangsu ,China."
            },
            {
                "name": "TAO Guang-zhou",
                "org": " Department of Radiation Oncology,Huai'an First Affiliated Hospital,Nanjing Medical University,Huai'an Jiangsu ,China."
            }
        ],
        "venue": "Journal of Modern Oncology",
        "year": 2011
    },
    "17sISKyf": {
        "id": "17sISKyf",
        "title": "A randomized controlled trial of intensity-modulated radiation therapy plus docetaxel and cisplatin versus simple intensity-modulated radiation therapy in II-III stage esophageal carcinoma]",
        "abstract": "To compare the efficacy and toxicity of intensity- modulated radiation therapy plus chemotherapy (IMRT-TP) with simple intensity-modulated radiation therapy (IMRT) in the treatment of locally advanced esophageal carcinoma.A total of 170 eligible patients with locally advanced esophageal carcinoma were recruited prospectively from September 2004 to April 2008 and randomly divided into IMRT-TP group and IMRT group. Two groups were treated with IMRT of 6MV-X. The radiation dose was 60 Gy in 30 fractions in IMRT-TP group and 66 Gy in 30 fractions in IMRT group. The regimen of chemotherapy consisted of docetaxel and cisplatin in IMRT-TP group for 2 cycles.Of 170 patients, 160 completed the trial, including 75 patients of IMRT-TP group and 85 of IMRT group. As compared to IMRT group, total recurrence rate [69.3% (52/75) vs. 84.7% (72/85), P=0.020] and local recurrence rate [50.7% (38/75) vs. 67.1% (57/85), P=0.035] decreased in IMRT-TP group, the 5-year overall survival (29.3% vs. 15.3%, P=0.031) and 5-year recurrence free survival (24.0% vs. 10.6%, P=0.015) increased in IMRT-TP group. While severe side effect ratio increased obviously in IMRT-TP group [54.7% (41/75) vs. 4.7% (4/85), P=0.000].As compare to simple IMRT, IMRT plus docetaxel and cisplatin can decrease the local recurrence rate, prolong the overall survival and regression-free survival, but bring more side effects.",
        "keywords": [],
        "authors": [
            {
                "name": "Fu-Zhi Ji",
                "org": "Department of Radiation Oncology, Huai'an First People's Hospital, Nanjing Medical University, Jiangsu Huai'an 223300, China. jshazwg@126.com."
            },
            {
                "name": "Wei-Guo Zhu",
                "org": ""
            },
            {
                "name": "Chang-Hua Yu",
                "org": ""
            },
            {
                "name": "Guang-Zhou Tao",
                "org": ""
            },
            {
                "name": "Peng Pan",
                "org": ""
            },
            {
                "name": "Xi-Lei Zhou",
                "org": ""
            },
            {
                "name": "Tao Li",
                "org": ""
            }
        ],
        "venue": "Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery",
        "year": 2013
    },
    "imypOBHU": {
        "id": "imypOBHU",
        "title": "Simultaneous integrated boost intensity-modulated radiation therapy for mediastinum metastasis in patients with esophageal carcinoma after operation",
        "abstract": "Objective:To investigate the clinical efficacy and significance of simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) for the patients with esophageal carcinoma after the radical esophagectomy and with mediastinal metastasis.Methods:SIB-IMRT plans were designed for 39 patients with esophageal carcinoma after the radical esophagectomy and with mediastinal metastasis.Two target volumes were predefined:PTV1,the target volume of the lymph node region,which was given to 69Gy(2.3Gy fractions),and PTV2,the target volume of electively treated region,which was given to 54Gy(1.8Gy fractions).Five equispaced coplanar beams were applied.Results:The plan with 5 intensity-modulated beams could produce good dose distribution for the two target volumes.All the patients completed the treatments in 6 weeks.The outcome was evaluated 3 months after SIB-IMRT.Patients had CR in 66.7%(36/54);PR 33.3%(18/54).The overall response rate was 100.0%.Conclusion:SIB-IMRT can reach a higher value of some radiation physical parameters for the patients with esophageal carcinoma after the radical esophagectomy and with mediastinal metastasis.Local-regional control rate was improved by using SIB-IMRT.The acute radiation toxicity of SIB-IMRT was well tolerated.SIB-IMRT is a promising radiotherapy modality for the advanced esophageal carcinoma.",
        "keywords": [
            "simultaneous integrated boost radiation therapy",
            "mediastinum metastasis",
            "intensity-modulated radiation therapy",
            "esophageal neoplasms"
        ],
        "authors": [
            {
                "name": "YU Chang-hua",
                "org": " Department of Radiation Oncology,Huai'an First People Hospital,Huai'an ,China"
            },
            {
                "name": "ZHU Zhen-ya",
                "org": " Department of Radiation Oncology,Huai'an First People Hospital,Huai'an ,China"
            },
            {
                "name": "HAN Ji-hua",
                "org": " Department of Radiation Oncology,Huai'an First People Hospital,Huai'an ,China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": " Department of Radiation Oncology,Huai'an First People Hospital,Huai'an ,China"
            },
            {
                "name": "PAN Peng",
                "org": " Department of Radiation Oncology,Huai'an First People Hospital,Huai'an ,China"
            },
            {
                "name": "LI Tao",
                "org": " Department of Radiation Oncology,Huai'an First People Hospital,Huai'an ,China"
            }
        ],
        "venue": "Journal of Modern Oncology",
        "year": 2010
    },
    "lZGHoPJ5": {
        "id": "lZGHoPJ5",
        "title": "Clinical study of carmofour and 3-dimensional conformal radiotherapy for old patients with esophageal cancer",
        "abstract": "Objective:To study the efficacy and adverse effects of carmofour combined with radiotherapy in old patients with esophageal cancer.Methods: Total of 130 old patients with esophageal cancer were randomized into two groups: 65 patients treated by radiotherapy alone and another 65 patients by chemoradiotherapy.The schedules of radiotherapy in two group were 3-DCRT in conventional fractionation,total dose 64-66Gy for radiotherapy alone group and 60Gy for chemoradiotherapy group,and chemoradiotherapy group was given carmofour 150mg,t.i.d.Results: The survival rates at 1-,3-and 5-year were 58.5%,38.5% and 24.6% in the concurrent chemoradiotherapy group,52.3%,23.1% and 10.8% in the radiotherapy alone group,respectively(P=0.033);and disease free survival rates at 1-,3-and 5-years were 52.3%,27.7%,15.4% and 47.7%,15.4%\u30013.1%(P=0.007);respectively,local recurrence in radiotherapy alone groups were 64.6% and 46.6% in chemoradiotherapy group(P=0.022).Acute toxicity in concurrent chemoradiotherapy group was higher than radiotherapy alone group,and later toxicity were similar in two group.Conclusion: Concurrent chemoradiotherapy with camofour could increased overall survival and disease free survival for old patients with esophageal cancer,and acute toxicity are tolerable.",
        "keywords": [
            "3-dimensional conformal radiotherapy",
            "esophageal neoplasms",
            "chemotherapy",
            "prognosis"
        ],
        "authors": [
            {
                "name": "LI Tao",
                "org": " Department of Radiation Oncology,First Hospital of Huaian,Nanjing Medical USniversity,Huaian ,China"
            },
            {
                "name": "ZHU Weiguo",
                "org": " Department of Radiation Oncology,First Hospital of Huaian,Nanjing Medical USniversity,Huaian ,China"
            },
            {
                "name": "HAN Jihua",
                "org": " Department of Radiation Oncology,First Hospital of Huaian,Nanjing Medical USniversity,Huaian ,China"
            },
            {
                "name": "YU Changhua",
                "org": " Department of Radiation Oncology,First Hospital of Huaian,Nanjing Medical USniversity,Huaian ,China"
            },
            {
                "name": "ZHOU Xilei",
                "org": " Department of Radiation Oncology,First Hospital of Huaian,Nanjing Medical USniversity,Huaian ,China"
            },
            {
                "name": "ZHANG Xiaoye",
                "org": " Department of Radiation Oncology,First Hospital of Huaian,Nanjing Medical USniversity,Huaian ,China"
            }
        ],
        "venue": "Journal of Modern Oncology",
        "year": 2011
    },
    "PR3qB5Eq": {
        "id": "PR3qB5Eq",
        "title": "Expression of LUNX mRNA in peripheral blood of non-small cell lung cancer patients and its clinical significance",
        "abstract": "Objective: To study the expression of LUNX mRNA in peripheral blood of patients with non small cell lung cancer(NSCLC) treated by chemotherapy,and evaluate its clinical value for diagnosis of micro-metastasis.By comparative analysis,it is to investigate the correlation among micro-metastasis,diagnosis,stage and the response of chemothe-rapy in NSCLC patients.Methods: RT-PCR was used to detect the LUNX mRNA in peripheral blood from 54 patients with NSCLC before and after platinum-based regimens in the combined chemotherapy,36 patients with malignant tumors except for lung cancer,16 patients with benign lung diseases and 15 healthy volunteers were served as controls.Results: The rate of positive expression of LUNX mRNA in peripheral blood of patients with NSCLC were 48.1%(26/54) and 25.9%(14/54),respectively before and after the treatment(P<0.05).The rate of positive expression of LUNX mRNA were 0%(0/36),0%(0/16) and 0%(0/15)in blood samples of 36 malignant tumors except lung cancer,16 benign lung diseases and 15 healthy volunteers respectively.There was significant different compare with NSCLC(P<0.01).The rate of positive expression of LUNX mRNA in peripheral blood of patients with NSCLC was significantly related to TNM stage(P<0.05).It had no obvious correlation with age,gender,pathological types or differentiation degree(P>0.05).The expression of LUNX mRNA in peripheral blood of patients with NSCLC had no obvious correlation with near future curative effect of chemotherapy.Conclusion: LUNX mRNA in peripheral blood can be used as prospective biomarkers for detecting micro-metastasis in patients with NSCLC.The rate of positive expression of LUNX mRNA in peripheral blood of patients with NSCLC was significantly related to TNM stage(P<0.05).There was not obvious correlation with age,gender,pathological types or differentiation degree(P>0.05).The rate of positive expression of LUNX mRNA in peripheral blood of patients with NSCLC was significantly descended after chemotherapy.Valid chemotherapy could eliminate the micro-metastasis cell in peripheral blood of patients with NSCLC.",
        "keywords": [
            "non-small cell lung cancer",
            "lung specific X protein",
            "micro-metastasis",
            "reverse transcriptase polymerase chain reaction"
        ],
        "authors": [
            {
                "name": "JI Fuzhi",
                "org": "Department of Oncology Radiotherapy,Affiliated Huai'an First Hospital of Nanjing Medical University,Huai'an "
            },
            {
                "name": "ZHU Weiguo",
                "org": "Department of Oncology Radiotherapy,Affiliated Huai'an First Hospital of Nanjing Medical University,Huai'an "
            },
            {
                "name": "PAN Peng",
                "org": "Department of Oncology Radiotherapy,Affiliated Huai'an First Hospital of Nanjing Medical University,Huai'an "
            },
            {
                "name": "ZHOU Xilei",
                "org": "Department of Oncology Radiotherapy,Affiliated Huai'an First Hospital of Nanjing Medical University,Huai'an "
            }
        ],
        "venue": "Journal of Nantong University(Medical Sciences)",
        "year": 2011
    },
    "ZIjlXWq7": {
        "id": "ZIjlXWq7",
        "title": "To compare the effects of mini thoractomy,thoracoscopic and video assisted  surgery for spontaneous pneumothorax",
        "abstract": "Objective To compare the effects of mini thoractomy,video assisted mini thoractomy and thoracoscopic surgery for spontaneous pneumothorax.Methods 186 patients with spontaneous pneumothorax were randomly divided into three groups: mini thoractomy group(n=86),video assisted mini thoractomy group(n=52) and thoracoscopic group(n=48).To evaluate the effcicacy indexs including surgery time,pain score,hospitalize time,and hemorrhage amount,et al.Results All the indexs had significant difference among these three groups(P<0.05);Mini thoractomy surgery time was the longest and thoracoscopic was the shortest(P<0.05).Thoracoscopic costed much more than the rest two groups(P<0.05).The recurrence of three groups had no significant difference(P>0.05).Conclusion Video-assisted mini thoractomy and thoracoscopic surgery for spontaneous pneumothorax were better than mini thoractomy,but the costs was higher.",
        "keywords": [
            "Mini thoractomy",
            "Video assisted mini thoractomy",
            "Spontaneous pneumothorax",
            "Thoracoscopic"
        ],
        "authors": [
            {
                "name": "YOU Zhen-bing",
                "org": "The First hospital of Huai'an,The Affiliated Hospital of Nan'jing Medical College,Huai'an ,Jiangsu,China"
            },
            {
                "name": "GUO Wei",
                "org": "The First hospital of Huai'an,The Affiliated Hospital of Nan'jing Medical College,Huai'an ,Jiangsu,China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": "The First hospital of Huai'an,The Affiliated Hospital of Nan'jing Medical College,Huai'an ,Jiangsu,China"
            }
        ],
        "venue": "Medical Journal of West China",
        "year": 2009
    },
    "D4Z1RUkg": {
        "id": "D4Z1RUkg",
        "title": "EPID for Set-up Errors Analysis and Quality Assurance of Radiotherapy in Head and Neck Cancer",
        "abstract": "Objective: This study was to investigate the set-up error using electronic portal imaging device (EPID) for intensity modulated radiation ( IMRT), assess of the CTV-to-PTV margins, analyze the factors on causing the error periodically, and to improve the quality control level. Methods: From October 2007 to January 2008, twelve, eleven, seventeen, and sixteen patients with head and neck carcinoma were enrolled in this study. The patients were immobilized with the head/neck shoulder immobilization system on margins. The set-up errors were analyzed by comparing the films of digitally reconstructed radiographs (DRR) with EPID. Electronic portal imaging was performed for twice each week before each treatment at the position AP (gantry angle 0\u00b0) and LT (gantry angle 90\u00b0), respectively. CTV-to-PTV margins were calculated by the equation 2.0\u03a3+0.7\u03c3 (\u03a3 is the systematic error, and \u03c3 is the random error) in the end of each month, the factors which might be the causes were analyzed and some quality control methods were proposed. Results: The theoretical CTV-to-PTV margins calculating by the equation was declined gradually during the previous three months and stable in the fourth month. Conclusions: This study supplied theoretical evidences and validated CTV-to-PTV margins for our department of radiotherapy by analyzing the set-up errors. This strategy may diminish the unnecessary irradiation fields and enhance the treatment outcome through the technique improvement.",
        "keywords": [
            "ElectronPortalImagingDevice(EPID)",
            "set-uperors",
            "qualityassurance",
            "margin",
            "radiotherapy"
        ],
        "authors": [
            {
                "name": "YU Chang-hua",
                "org": "Department of Radiation Oncology, First People's Hospital of Huaian, Nanjing Medical University, Huaian Jiangsu , China"
            },
            {
                "name": "HAN Ji-hua",
                "org": "Department of Radiation Oncology, First People's Hospital of Huaian, Nanjing Medical University, Huaian Jiangsu , China"
            },
            {
                "name": "ZHU Zhen-ya",
                "org": "Department of Radiation Oncology, First People's Hospital of Huaian, Nanjing Medical University, Huaian Jiangsu , China"
            },
            {
                "name": "ZHANG Xiao-ye",
                "org": "Department of Radiation Oncology, First People's Hospital of Huaian, Nanjing Medical University, Huaian Jiangsu , China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": "Department of Radiation Oncology, First People's Hospital of Huaian, Nanjing Medical University, Huaian Jiangsu , China"
            },
            {
                "name": "LI Tao",
                "org": "Department of Radiation Oncology, First People's Hospital of Huaian, Nanjing Medical University, Huaian Jiangsu , China"
            }
        ],
        "venue": "Chinese Journal of Medical Physics",
        "year": 2009
    },
    "urqgqQmA": {
        "id": "urqgqQmA",
        "title": "Dose escalation of domestic nedaplatin used in concurrent chemoradiotherapy for cervical cancer]",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Wei-Guo Zhu",
                "org": ""
            },
            {
                "name": "Chang-Hua Yu",
                "org": ""
            },
            {
                "name": "Tao Li",
                "org": ""
            }
        ],
        "venue": "Zhonghua zhong liu za zhi [Chinese journal of oncology]",
        "year": 2011
    },
    "9xxDH95c": {
        "id": "9xxDH95c",
        "title": "Outcomes of surgery or raditherapy for patients with recurrent esophageal cancer after radical radiotherapy",
        "abstract": "Objective To compare the outcomes of surgery or raditherapy for patients with recurrent esophageal cancer after radical radiotherapy.Methods Of 57 patients with recurrent esophageal squamous cell carcinoma after radical radiotherapy,23 patients(group A) underwent esophagectomy and 34 patients(group B) received radiotherapy again.The complications and survival rate were compared.Results The postoperative complications in group A were anastomotic leakage in 1 case and pulmonary infection in 3 cases.The radiotherapy of group B led to esophageal perforation in 1 case and tracheoesophageal fistula in 2 cases.Local recurrent rate in 3 years was lower in group A than that in group B(43.5% vs.82.4%)(P<0.05).The 1-,2-and 3-year tumor-free survival rates were 56.5%,34.8% and 26.1% in group A,which were higher than 41.2%,20.6% and 8.8% in group B(P<0.05).There was no significant dofference in overall 1-,2-and 3-year survial rates between two groups.Conclusion Surgery is a choice for the patients recurrent with esophageal squamous cell carcinoma after radical radiotherapy,which can decrease local recurrence and increase tumor-free survial rate.",
        "keywords": [
            "Radiotherapy",
            "Recurrence of esophageal cancer"
        ],
        "authors": [
            {
                "name": "XU Dafu",
                "org": ",et al.Department of Thoracic and Cardiovascular Surgery,Huaian First Hospital,Nanjing Medical University,Huaian , CHINA"
            },
            {
                "name": "YOU Zhenbing",
                "org": ",et al.Department of Thoracic and Cardiovascular Surgery,Huaian First Hospital,Nanjing Medical University,Huaian , CHINA"
            },
            {
                "name": "ZHU Weiguo",
                "org": ",et al.Department of Thoracic and Cardiovascular Surgery,Huaian First Hospital,Nanjing Medical University,Huaian , CHINA"
            }
        ],
        "venue": "Jiangsu Medical Journal",
        "year": 2011
    },
    "prGlrmrx": {
        "id": "prGlrmrx",
        "title": "Expression of HIF-1alpha in serum of primary hepatocellular carcinoma and effects on tumor invasion and metastasis]",
        "abstract": "To study the expression of HIF-1alpha in serum of primary hepatocellular carcinoma (PHC) and effects on tumor invasion and metastasis.The serum HIF-1alpha level from 60 cases of PHC patients and 60 cases of normal healthy individuals were detected by ELISA.The serum HIF-1alpha level of the PHC group was (161.14+/-80.79) pg/mL, the control group was (22.67+/-8.47) pg/mL, compared the different was significant (P<0.05). The serum HIF-1alpha level of distant metastasis of tumor group was (225.15+/-108.16) pg/mL, the no distant metastasis of tumor group was (101.26+/-55.18) pg/mL, compared the different was significant (P<0.05). The serum HIF-1alpha level of portal vein tumor thrombus group was (255.45+/-122.23) pg/mL. The no portal vein tumor thrombus group was (139.97+/-71.49) pg/mL, compared the different was significant (P<0.05). The serum HIF-1alpha level of tumor capsule group was (99.97+/-55.75) pg/mL. The no tumor capsule group was (187.36+/-91.52) pg/mL, compared the different was significant (P<0.05). The serum HIF-1alpha level was no significantly different among the different age, gender, TNM stage and tumor diameter.The serum HIF-1alpha has high expression in PHC. The serum HIF-1alpha expression has close relation with the whether distant metastasis of tumor, portal vein tumor thrombus and tumor capsule. The serum HIF-1alpha level can predict the invasion and metastasis of PHC.",
        "keywords": [
            "hif-1\u03b1",
            "primary hepatocellular carcinoma",
            "invasion and metastasis",
            "tumor"
        ],
        "authors": [
            {
                "name": "Da-hong Zhang",
                "org": " Department of Oncology,Affiliated Huaian First Hospital of Nanjing Medical University,Huaian ,China"
            },
            {
                "name": "Wei-guo Zhu",
                "org": " Department of Oncology,Affiliated Huaian First Hospital of Nanjing Medical University,Huaian ,China"
            },
            {
                "name": "Shun Yue",
                "org": " Department of Oncology,Affiliated Huaian First Hospital of Nanjing Medical University,Huaian ,China"
            }
        ],
        "venue": "Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology",
        "year": 2011
    },
    "2iH4p8q4": {
        "id": "2iH4p8q4",
        "title": "The efficacy comparison of concurrent chemoradiotherapy or radiotherapy alone in postoperative patient with N1 esophageal carcinoma",
        "abstract": "Objective: To study the efficacy of concurrent chemoradiotherapy or radiotherapy alone in postoperative patient with N1 esophageal carcinoma.Methods: From October 2003 to October 2005,68 eligible patients with N1 esophageal carcinoma were randomized into radiotherapy alone group(RT,34 cases) and concurrent chemoradiotherapy group(CRT,34 cases).The schedules of radiotherapy in both groups were same,with 3-DCRT with conventional fractionation,and total dose is 54 Gy.The regiment of chemotherapy for the CRT group was consisted of DDP and 5-Fu for 2 cycles.It started on the first day of radiotherapy and repeated since the 29 day.Results: The overall survival rates at 1-,3-,and 5-year were 70.5%,38.2%,and 26.5% in the RT group,73.5%,47.1%,and 35.3% in the CRT group,respectively(P = 0.359);and the disease-free survival rates at 1-,3-,and 5-year were 58.8%,26.5%,and 14.7% in the RT group,64.7%,47.1%,and 26.5% in the CRT group respectively.The acute toxicity of chemoradiotherapy in the CRT group were higher than the RT group;later toxicity of two groups were similar.Conclusion: There was a trend of better survival in postoperative patient with N1 esophageal carcinoma treated with CRT than with the RT alone.However,the acute toxicity of chemoradiotherapy in the CRT group was higher than the RT group.",
        "keywords": [
            "lymph node metastasis",
            "esophageal neoplasm",
            "radiotherapy",
            "chemotherapy",
            "surgery"
        ],
        "authors": [
            {
                "name": "ZHONG Qin",
                "org": "Department of Radiation Oncology,Huai'an NO.1 Hospital Affiliated with NJMU,Huai'an,,China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": "Department of Radiation Oncology,Huai'an NO.1 Hospital Affiliated with NJMU,Huai'an,,China"
            },
            {
                "name": "JIA Zheng-fei",
                "org": "Department of Radiation Oncology,Huai'an NO.1 Hospital Affiliated with NJMU,Huai'an,,China"
            },
            {
                "name": "FENG Yong",
                "org": "Department of Radiation Oncology,Huai'an NO.1 Hospital Affiliated with NJMU,Huai'an,,China"
            }
        ],
        "venue": "Acta Universitatis Medicinalis Nanjing(Natural Science)",
        "year": 2011
    },
    "7OEcNBAB": {
        "id": "7OEcNBAB",
        "title": "Efficacy of postoperative capecitabine-based chemotherapy in gastric cancer after D1/D2 curative resection",
        "abstract": "Objective:To investigate the efficacy and toxicity of postoperativechemoradiation using oxaliplatin chemotherapy and oral capecitabine during radiation for gastric cancer following D1/D2 curative resection.Methods:One-hundred and twelve patients with gastric cancer who underwent potentially D1/D2 curative resection,accepted oxaliplatin chemotherapy and oral capecitabin(capecitabine 1000mg/m2,twice a day,d1-14;oxaliplatin 100 mg/m2,d1,total 4 cycles) during radiation(45Gy/25f).We compared survival in these patients with 110 gastric cancer patients who had similar history and received a same chemotherapy regimen.Results:1-year,2-year,and 3-year overall survival rates of patients receiving concurrent chemoradiotherapy were 71.4%,61.6%,and 50.9%,respectively,whereas for gastric cancer patients receiving chemotherapy alone,the survival rates were 70.0%,51.8%,and 36.4%,respectively(P=0.058);the 1-year,2-year,and 3-year disease-free survival rates for gastric cancer patients receiving concurrent chemoradiotherapy were 67.0%,58.9%,and 46.4%,respectively.Gastric cancer patients receiving chemotherapy alone exhibited a survival rate of 60.9%,37.3%,and 28.2%,respectively(P =0.003).The major side response was grade 1/2 haematological and gastrointestinal toxicity.Grade 3/4 toxicities in chemoradiotherapy group included leucopenia in 17.9%,nausea/vomiting in 6.3% and diarrhea in 4.5%,in control group included leucopenia in 10.9%,nausea/vomiting in 2.7% and diarrhea in 2.7%.Neither grade 3/4 hand foot syndrome nor treatment related death were observed.Conclusion:Oxaliplatin chemotherapy and oral capecitabine during radiation for gastric cancer following D1/D2 curative resection could increase disease-free survival rate,and with less toxicity.",
        "keywords": [
            "gastric cancer",
            "capecitabin",
            "concurrent chemoradiotherapy",
            "oxaliplatin"
        ],
        "authors": [
            {
                "name": "PU Juan",
                "org": "Department of Radiation Oncology,People Hospital of Lianshui County,Jiangsu Huaian ,China"
            },
            {
                "name": "ZHU Weiguo",
                "org": "Department of Radiation Oncology,Huaian No.1 Hospital,Nanjing Medical University,Jiangsu Huaian ,China."
            },
            {
                "name": "LI Tao",
                "org": "Department of Radiation Oncology,Huaian No.1 Hospital,Nanjing Medical University,Jiangsu Huaian ,China."
            },
            {
                "name": "YU Changhua",
                "org": "Department of Radiation Oncology,Huaian No.1 Hospital,Nanjing Medical University,Jiangsu Huaian ,China."
            },
            {
                "name": "ZHANG Tiecheng",
                "org": "Department of Radiation Oncology,Huaian No.1 Hospital,Nanjing Medical University,Jiangsu Huaian ,China."
            },
            {
                "name": "WANG Chengshi",
                "org": "Department of Radiation Oncology,People Hospital of Lianshui County,Jiangsu Huaian ,China"
            }
        ],
        "venue": "Journal of Modern Oncology",
        "year": 2012
    },
    "d7GznFPW": {
        "id": "d7GznFPW",
        "title": "Application of simplified intensity modulated radiation therapy in gastric cancer after operation]",
        "abstract": "To elucidate the application and the dosimetry characteristic of the simplified intensity modulated radiation therapy (sIMRT) for gastric cancer after operation, and to compare the dose distribution with intensity modulated radiation therapy (IMRT) and three-dimension conformal radiation therapy (3D-CRT).Twelve patients with gastric cancer after operation were enrolled in this study. 3D-CRT plan, 5-field IMRT plans (20 degree, 80 degree, 180 degree, 280 degree, 340 degree) and 5-field sIMRT plans (20 degree, 80 degree, 180 degree, 280 degree, 340 degree) were performed for each patient. The conformal index (CI), heterogeneity index (HI) of the planning target volume (PTV) and the dose of normal organs were analyzed with the dose volume histogram (DVH). The total MU and treatment time were also compared.The sIMRT and IMRT plans had comparable CI (sIMRT>IMRT>3D-CRT), and showed better dose conformity but worse homogeneity than 3D-CRT. The percentage of volume receiving 20 Gy, 25 Gy, 30 Gy and 40 Gy by liver were significantly lower in sIMRT than that in 3D-CRT, and comparable to IMRT. All the dose volumes to kidneys with sIMRT were still significantly lower as compared to 3D-CRT, and comparable to IMRT. The sIMRT plan was better than IMRT plan in total MU and treatment time.sIMRT has comparable dose distribution in patients with gastric cancer to IMRT, but is significantly better than 3D-CRT. Treatment time of sIMRT is the shortest. So sIMRT technique can be applied more simply.",
        "keywords": [],
        "authors": [
            {
                "name": "Yan Zhang",
                "org": "Department of Radiation Oncology, The First People's Hospital of Huai'an, Nanjing Medical University, Jiangsu Huai'an 223300, China. jshazwg@126.com"
            },
            {
                "name": "Wei-guo Zhu",
                "org": ""
            },
            {
                "name": "Ji-hua Han",
                "org": ""
            },
            {
                "name": "Xiao-ye Zhang",
                "org": ""
            },
            {
                "name": "Guang-zhou Tao",
                "org": ""
            },
            {
                "name": "Tao Li",
                "org": ""
            },
            {
                "name": "Chang-hua Yu",
                "org": ""
            }
        ],
        "venue": "Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery",
        "year": 2013
    },
    "hLNi3qsp": {
        "id": "hLNi3qsp",
        "title": "Clinical study of concurrent chemoradiotherapy or radiotherapy alone for esophageal cancer patients with positive lymph node metastasis.",
        "abstract": "Esophageal cancer patients with pathologic lymph node involvement generally have a poor prognosis. Many randomized controlled trials have not achieved consistent results similar to those of the RTOG8501 trial, and the long-term survival rate has not increased. The present study aimed to compare the efficacy and toxic side effects of concurrent chemoradiotherapy and radiotherapy alone to treat N1 esophageal carcinoma.A total of 130 N1 esophageal carcinoma patients were enrolled and randomly divided into two groups: concurrent chemoradiotherapy group (n = 65) and radiotherapy group (n = 65). Both groups received three-dimensional conformal radiotherapy with a total dose of 64-66 Gy. Meanwhile, to the concurrent chemoradiotherapy group, an additional chemotherapy protocol (nedaplatin, 20 mg/m\u00b2/d, 5-FU, 500 mg/m\u00b2/d for four days) was given from day 1, and such treatment was repeated until day 29. From day 21 after radiotherapy, two cycles of a consolidated chemotherapy protocol were given at an interval of 28 days.The survival rates at one, two, and three years were 72.3%, 55.3%, and 40% in the concurrent chemoradiotherapy group, respectively, and 75.3%, 38.5%, and 18.5% in the radiotheray group (P = 0.007), respectively. The survival rates of the patients in the concurrent chemoradiotherapy group who completed one to two cycles and three to four cycles at one, two, and three years were 70%, 53.3%, and 30%, and 74.2%, 57.1%, 48.6% (P = 0.128), respectively. Three-year distant metastasis rates were 10.7% in the concurrent chemoradiotherapy group and 16.9% in the radiotherapy group. Acute toxicity in the concurrent chemoradiotherapy group was higher than in the radiotherapy group. Late toxic side effects were similar in the two groups.Compared with radiotherapy alone, concurrent chemoradiotherapy in the treatment of esophageal carcinoma with local lymph node enlargement can improve the three-year survival rate. Moreover, completion of three to four cycles of chemotherapy may have better efficacy than one to two cycles.",
        "keywords": [],
        "authors": [
            {
                "name": "Jihua Han",
                "org": "Department of Radiation Oncology, First Hospital of Huaian, Nanjing Medical University, Huaian, China."
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            },
            {
                "name": "Changhua Yu",
                "org": ""
            },
            {
                "name": "Xilei Zhou",
                "org": ""
            },
            {
                "name": "Tao Li",
                "org": ""
            },
            {
                "name": "Xiaoye Zhang",
                "org": ""
            }
        ],
        "venue": "Tumori",
        "year": 2012
    },
    "R2oTgAJB": {
        "id": "R2oTgAJB",
        "title": "Expression and clinical significance of VEGF in tissue of primary hepatocellular carcinoma]",
        "abstract": "To study the expression and clinical significance of vaseular endothelial growth factor (VEGF) in tissue of primary hepatocellular carcinoma (PHC) and effects on tumor invasion and metastasis.The VEGF expression from 60 cases of PHC tissues, 30 cases of adjacent tissues and 30 cases of normal tissue were detected by SP immunohistochemical method.The VEGF positive rate of the PHC group was 68.3%, the adjacent tissues group was 40.0%, and the normal tissue group was 33.3%, compared the different was significant (P<0.05); The VEGF positive rate of the incomplete capsule tissues was 92.9%, which was significantly higher than the complete capsule tissues (P<0.05); and the VEGF positive rate was no significantly different among the different TNM stage, different degree of tumor differentiation and different lesion size (P<0.05).The VEGF has high expression in PHC tissues. The VEGF expression has close relation with the whether tumor capsule and distant metastasis. The VEGF plays an important role angiogenesis of PHC, growth and metastasis.",
        "keywords": [
            "primary hepatocellular carcinoma",
            "sp immunohistochemical method",
            "vegf"
        ],
        "authors": [
            {
                "name": "Da-hong Zhang",
                "org": " Department of Oncology, Affiliated Huaian First Hospital of Nanjing Medical University, Jiangsu Huaian ,China"
            },
            {
                "name": "Wei-guo Zhu",
                "org": " Department of Oncology, Affiliated Huaian First Hospital of Nanjing Medical University, Jiangsu Huaian ,China"
            },
            {
                "name": "Shun Yue",
                "org": " Department of Oncology, Affiliated Huaian First Hospital of Nanjing Medical University, Jiangsu Huaian ,China"
            }
        ],
        "venue": "Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology",
        "year": 2011
    },
    "OZbHonPC": {
        "id": "OZbHonPC",
        "title": "To compare the therapeutic effect of two kinds of transthoracic operative approach for 420 patients with middle thoracic esophageal cancer",
        "abstract": "Objectives To compare the different therapeutic effect of left or right transthoracic operative approach for middle thoracic esophageal cancer. Methods A total of 420 consecutive patients with middle thoracic esophageal squamous cell carcinoma(ESCC) received transthoracic esophagectomy between January 2003 and January 2006. The patients were divided into left approach group(n = 250) and right approach group(n = 170) . The postoperative complications,lymphagectomy,and survival rate of the two groups were compared retrospectively. Results The incidence of postoperative complications was higher in right approach group than in left approach group(50.6% vs 35.2%,P < 0.001) . The number of lymph nodes resected in right approach group was more than in left approach group(14.0 \u00b1 2.3 vs 10.6 \u00b1 1.4,P < 0.001) . Lymphatic recurrence rate was lower in right approach group than in left approach group(45.3% vs 54.4%,P = 0.67) . The 1-,2-,3-year overall survival rate was 74.8%,54.0%,41.2% in left approach group and 72.9%,59.4%,50.6% in right approach group(P = 0.093) . The 1-,2-,3-year disease-free survival rate was 58.0%,46.0%,36.0% in left approach group and 64.1%,54.1%,46.5% in right approach group respectively(\u03c72 = 4.073,P = 0.044) . Conclusion Right transthoracic resection increased the incidence of complications,but it could reduce lymphatic recurrence rate and increase disease-free survival rate.",
        "keywords": [
            "Surgical operation",
            "Esophagus neoplasm",
            "Lymphadenectomy",
            "Efficacy",
            "Postoperative complications"
        ],
        "authors": [
            {
                "name": "YOU Zhen-bing",
                "org": ". Huai\u2032an First Hospital,Nanjing Medical University,Huai\u2032an ,China"
            },
            {
                "name": "XU Da-fu",
                "org": ". Huai\u2032an First Hospital,Nanjing Medical University,Huai\u2032an ,China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": ". Huai\u2032an First Hospital,Nanjing Medical University,Huai\u2032an ,China"
            },
            {
                "name": "JI Jian",
                "org": ". Huai\u2032an First Hospital,Nanjing Medical University,Huai\u2032an ,China"
            },
            {
                "name": "CHU Hong-jun",
                "org": ". Huai\u2032an First Hospital,Nanjing Medical University,Huai\u2032an ,China"
            },
            {
                "name": "GUO Wei",
                "org": ". Huai\u2032an First Hospital,Nanjing Medical University,Huai\u2032an ,China"
            }
        ],
        "venue": "The Journal of Practical Medicine",
        "year": 2011
    },
    "37rAuRJv": {
        "id": "37rAuRJv",
        "title": "Prognostic significance of combined microRNA-206 and CyclinD2 in gastric cancer patients after curative surgery: A retrospective cohort study.",
        "abstract": "To investigate associations of microRNA (miR)-206 and CyclinD2 (CCND2) expression, alone or in combination, with clinicopathological characteristics and patients' prognosis in gastric cancer.MiR-206 and CCND2 mRNA expression levels were detected by real-time quantitative RT-PCR in 220 self-pairs of gastric cancer and adjacent non-cancerous tissues.Compared with the adjacent non-cancerous tissues, the expression levels of miR-206 and CCND2 mRNA were respectively reduced and elevated in gastric cancer tissues dramatically (both P<0.001). Notably, the expression levels of miR-206 in gastric cancer tissues were negatively correlated with those of CCND2 mRNA significantly (r=-0.463, P<0.001). Then, statistical analysis showed that low miR-206 expression and high CCND2 expression, alone or in combination, were all significantly associated with great depth of invasion, positive lymph node and distant metastases, and advanced TNM stage of human gastric cancer (all P<0.05). After that, we also found that the overall survivals of the patients with low miR-206 expression and high CCND2 expression were respectively shorter than those with high miR-206 expression and low CCND2 expression. More interestingly, miR-206-low/CCND2-high expression was associated with a significantly worst overall survival of all miR-206/CCND2 groups (P<0.001). Furthermore, multivariate analysis identified miR-206 and/or CCND2 expression as independent prognostic factors for overall survival in patients with gastric cancer.Our data provide evidence that the dysregulation of miR-206-CCND2 axis may contribute to the aggressive progression and poor prognosis of human gastric cancer in clinical settings. Combined detection of their expression might be particularly helpful for surveillance of disease progression and treatment stratification.",
        "keywords": [
            "cyclind2",
            "gastric cancer",
            "microrna-206",
            "prognosis",
            "quantitative real-time polymerase chain reaction"
        ],
        "authors": [
            {
                "name": "Huichang Shi",
                "org": "Department of Oncology, First Hospital of Huai'an, Nanjing Medical University, Huai'an 223300, China."
            },
            {
                "name": "Jun Han",
                "org": "Department of Oncology, First Hospital of Huai'an, Nanjing Medical University, Huai'an 223300, China."
            },
            {
                "name": "Shun Yue",
                "org": "Department of Oncology, First Hospital of Huai'an, Nanjing Medical University, Huai'an 223300, China."
            },
            {
                "name": "Tiecheng Zhang",
                "org": "Department of Oncology, First Hospital of Huai'an, Nanjing Medical University, Huai'an 223300, China."
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Oncology, First Hospital of Huai'an, Nanjing Medical University, Huai'an 223300, China."
            },
            {
                "name": "Dahong Zhang",
                "org": "Department of Oncology, First Hospital of Huai'an, Nanjing Medical University, Huai'an 223300, China."
            }
        ],
        "venue": "Biomedicine & pharmacotherapy = Biom\u00e9decine & pharmacoth\u00e9rapie",
        "year": 2015
    },
    "14S77Ry9": {
        "id": "14S77Ry9",
        "title": "Combined downregulation of microRNA-133a and microRNA-133b predicts chemosensitivity of patients with esophageal squamous cell carcinoma undergoing paclitaxel-based chemotherapy.",
        "abstract": "microRNA-133a (miR-133a) and miR-133b, located on chromosome 18 in the same bicistronic unit, have been commonly identified as being downregulated in esophageal squamous cell carcinoma (ESCC). The aim of this study was to investigate the correlation of miR-133a/b expression with efficacy of paclitaxel-based chemotherapy and clinical outcome of ESCC patients. miR-133a expression and miR-133b expression were examined in 100 newly diagnosed ESCC patients prior to treatment by quantitative real-time PCR. Then, the patients received four cycles of paclitaxel-based chemotherapy, the short-term treatment efficacy was evaluated, and a 3-year follow-up was performed. Expression levels of miR-133a and miR-133b were both significantly lower in ESCC tissues compared to adjacent noncancerous tissues (both P < 0.001). In addition, combined miR-133a/b downregulation was found to be closely correlated with advanced tumor stage (P = 0.02) and poor differentiation (P = 0.01). Moreover, the response rate of ESCC patients to paclitaxel-based chemotherapy was significantly higher in combined miR-133a/b downregulation group compared with other groups (P = 0.02). Furthermore, univariate and multivariate Cox analyses revealed that tumor stage and combined expression of miR-133a/b were independent prognosis factors in ESCC patients. Our data offer the convincing evidence that combined expression of miR-133a and miR-133b may predict chemosensitivity of patients with ESCC undergoing paclitaxel-based chemotherapy, implying its importance in applying 'personalized cancer medicine' in the clinical treatment of ESCC. We also identified combined expression of miR-133a and miR-133b as an effective prognostic marker of this malignancy.",
        "keywords": [
            "microRNA-133",
            " Esophageal squamous cell carcinoma",
            " Chemosensitivity",
            " Prognosis",
            " Quantitative real-time PCR"
        ],
        "authors": [
            {
                "name": "Guiming Chen",
                "org": "Department of Thoracic Surgery, Lian'shui County People's Hospital, Lian'shui, 223400, Jiangsu, China."
            },
            {
                "name": "Jin Peng",
                "org": "Department of Radiotherapy, Huai\u2019an First People\u2019s Hospital,Nanjing Medical University,Huai\u2019an,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Radiotherapy, Huai\u2019an First People\u2019s Hospital,Nanjing Medical University,Huai\u2019an,China"
            },
            {
                "name": "Guangzhou Tao",
                "org": "Department of Radiotherapy, Huai\u2019an First People\u2019s Hospital,Nanjing Medical University,Huai\u2019an,China"
            },
            {
                "name": "Yaqi Song",
                "org": "Department of Radiotherapy, Huai\u2019an First People\u2019s Hospital,Nanjing Medical University,Huai\u2019an,China"
            },
            {
                "name": "Xilei Zhou",
                "org": "Department of Radiotherapy, Huai\u2019an First People\u2019s Hospital,Nanjing Medical University,Huai\u2019an,China"
            },
            {
                "name": "Wanwei Wang",
                "org": "Department of Radiotherapy, Huai\u2019an First People\u2019s Hospital,Nanjing Medical University,Huai\u2019an,China"
            }
        ],
        "venue": "Medical oncology (Northwood, London, England)",
        "year": 2014
    },
    "UsWHFSup": {
        "id": "UsWHFSup",
        "title": "Comparison of the Effect of Nedaplatin and Cisplatin in the Concurrent Chemoradiotherapy of Cervical Cancer",
        "abstract": "Objective:To evaluate the effect and side-effect of Nedaplatin and cisplatin(DDP) in concur-rent chemoradiotherapy(CCRT) treatment of cervical cancer.Methods:68 first treated cervical cancer patients were randomly classified to two groups,Nedaplatin group and DDP group. Radiotherapy in two groups was the same,which used external radiation with 3 dimensional conformal radiation therapy technic(3-DCRT) and high dose rate intracavitary therapy.The radiation and CCRT started at the same time,and the frequence was once every week for 6 weeks. The Nedaplatin group was given Nedaplatin 40 mg/m2,ivgtt,weekly,for 6 weeks. DDP group was given DDP 40 mg/m2,ivgtt,weekly,for 6 weeks. The effects and side-effects of treatment in two groups were observed and compared.Results:All patients had finished CCRT treatment and followed up. Overall survival rate at 1,2,3 years in Nedaplatin group and DDP group were 91.2%\u300182.4%\u300176.5% and 85.3%\u300173.5%\u300170.6%(P>0.05) respectively. Disease free survival rate at 1,2,3 years in Nedaplatin group and DDP group were 88.2%\u300173.5%\u300164.7% and 82.3%\u300164.7%\u300161.8%(P>0.05) respectively. Incidence of grand \u2160 and grand \u2161 anorexia was 17.6%(6/34) and 35.3%(12/34)(P<0.05) ,incidence of grade \u2160 and \u2161 nausea and vomiting reaction were 20.6%(7/34) and 55.9%(19/34)(P<0.05) . The descending percentage of hemoglobin in two groups were 17.6%(6/34) and 35.3%(12/34) respectively(P<0.05) . Incidence of grand\u2160and grand \u2161 nephrotoxicity were 5.9%(2/34) and 32.3%(11/34) (P<0.05) . Incidence of grand\u2160and grand \u2161 thrombocytopenia were 38.2%(13/34) and 17.6%(6/34)(P<0.05) .Conclusions:Nedaplatin can be used in CCRT in cervical cancer. The side effects of Nedaplatin including gastrointestinal reaction and renal toxicity are lower than that of cisplatin. The total survival rate and disease free survival rate are the same,but tends to elevate in Nedaplatin,which is worth to give further study by enlarging the sample size.",
        "keywords": [
            "Cisplatin",
            "Concurrent chemoradiotherapy",
            "Nedaplatin",
            "Cervical cancer"
        ],
        "authors": [
            {
                "name": "WANG Hairong",
                "org": "Huaian First People Hospital,Huaian Jiangsu ,China"
            },
            {
                "name": "YU Changhua",
                "org": "Huaian First People Hospital,Huaian Jiangsu ,China"
            },
            {
                "name": "ZHU Weiguo",
                "org": "Huaian First People Hospital,Huaian Jiangsu ,China"
            }
        ],
        "venue": "Journal of Practical Obstetrics and Gynecology",
        "year": 2011
    },
    "BoNVPV0m": {
        "id": "BoNVPV0m",
        "title": "CLINICAL EVALUATION OF CHEMOTHERAPY COMBINED WITH THREE-DIMENSIONAL CONFORMAL RADIOTHERAPY FOR TREATMENT OF PATIENTS WITH ADVANCED GASTRIC CANCER",
        "abstract": "[Objective]To evaluate the efficacy and toxicity in advanced gastric cancer patients treated by chemotherapy combined with three-dimensional conformal radiotherapy.[Methods]85 cases of advanced gastric cancer patients were randomly divided into treatment group(42cases)and control group(43 cases).The treatment group was given for the treatment of chemotherapy combined with three-dimensional conformal radiotherapy,and the control group was given for the treatment of chemotherapy.After treatment,the short-term efficacy and toxicity were evaluated.The objective response and the survival rate were evaluated after following up for 1-year.[Results]The short-term efficacy rate of the treatment group was 81.0%,and it was higher than the control group(57.1%),the difference was significant between the two groups(P\ufe64 0.05);The one year survival rate and median disease progression time of the treatment group were significantly higher the control group(P\ufe640.05);The incidence of toxicity was no significant difference between the two groups(P\ufe650.05).[Conclusion]The chemotherapy combined with three-dimensional conformal radiotherapy for treatment of advanced gastric cancer patients have better efficacy and lower toxicity,and the therapy method is worthy to be popularized.",
        "keywords": [
            "Chemotherapy",
            "Advanced gastric cancer",
            "Three-dimensional conformal radiotherapy"
        ],
        "authors": [
            {
                "name": "ZHANG Da-hong",
                "org": "Department of Oncology,Affiliated Huaian First Hospital of Nanjing Medical University,Huaian ,China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": "Department of Oncology,Affiliated Huaian First Hospital of Nanjing Medical University,Huaian ,China"
            },
            {
                "name": "YUE Shun",
                "org": "Department of Oncology,Affiliated Huaian First Hospital of Nanjing Medical University,Huaian ,China"
            }
        ],
        "venue": "Modern Preventive Medicine",
        "year": 2010
    },
    "LKalp0jm": {
        "id": "LKalp0jm",
        "title": "Application of fast-track surgery in the management of patients with esophageal cancer]",
        "abstract": "To evaluate the influence of fast-track surgery in perioperative period on the clinical outcomes of patients with esophageal cancer.Clinical data of 117 patients with esophageal cancer between January 2011 and June 2011 were retrospectively analyzed. Sixty-three cases (study group) were treated with fast-track surgery and 54 cases(control group) were treated according to routine protocol in the perioperative period.The operative time, time to drainage tube removal, and length of hospital stay were significantly shorter in the study group than those in the control group(all P<0.05). Compared with the control group, the medical cost was lower(P<0.05). The overall postoperative complication rate was 7.9% in the study group and 24.1% in the control group(P<0.05).Fast-track surgery in the perioperative period for patients with esophageal cancer can promote bowel function recovery and decrease morbidity.",
        "keywords": [],
        "authors": [
            {
                "name": "Zhen-bing You",
                "org": "Department of Thoracic Surgery, Nanjing Medical University, Jiangsu Huai'an, China."
            },
            {
                "name": "Da-fu Xu",
                "org": ""
            },
            {
                "name": "Jian Ji",
                "org": ""
            },
            {
                "name": "Wei Guo",
                "org": ""
            },
            {
                "name": "Wei-guo Zhu",
                "org": ""
            },
            {
                "name": "Yong Xiao",
                "org": ""
            }
        ],
        "venue": "Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery",
        "year": 2012
    },
    "Ww7edh7U": {
        "id": "Ww7edh7U",
        "title": "Three dimensional conformal radiotherapy with late course accelerated hyper-fractionation for ad- vanced esophageal carcinoma",
        "abstract": "Objective To evaluate the results and toxic effects in three dimensional radiotherapy (3DCRT)with late course accelerated hyper-fractionation for advanced esophageal carcinoma.Methods From December 2001 to December 2003,115 patients were randomly divided into two groups:in 3DCRT group,55 patients were given late course accelerated hyper-fractionation radiotherapy to a total close of 66 Gy (2.0 Gy per fraction,5 times per week;to a dose of 36 Gy were changed into 1.5 Gy/f,2 f/d).In CF group,60 patients were given late course accelerated hyper-fractionation radiotherapy to a total dose of 66 Gy.Results The 1-, 2-,3-,4-year survival rates in 3DCRT group were 63.6 %, 50.9 %, 38.2 %, 30.9 % compared to 58.3 %, 38.3 %,33.3 %,23.3 % in CF group(X~2=4.44,P=0.031),and local control rates in 1-,2-,3-,and 4- years in 3DCRT group were 72.7 %,58.1%,47.2 % and 36.3 %,compared to 53.3 %,40 %,28.3 %,and 20 %(X~2=5.33,P=0.013)in CF group.However,in the 3DCRT group,the incidence of acute esophagitis was similar to CF group; hematogenous toxic and acute bronchitis were similar between the two groups. Late course lung injury in CF group was higher than that in 3DCRT group.Conclusion 3DCRT is able to improve the local control rate and survival rate,and unable to improve acute and late radiation toxie effects.",
        "keywords": [
            "computer-assisted",
            "Treatment outcome",
            "Radiotherapy",
            "Esophageal neoplasms"
        ],
        "authors": [
            {
                "name": "ZHU Wei-guo",
                "org": ". Department of Radiation Oncology, First Hospital of Huaian,Nanjing Medical College,Huaian ,China"
            },
            {
                "name": "HAN Ji-hua",
                "org": ". Department of Radiation Oncology, First Hospital of Huaian,Nanjing Medical College,Huaian ,China"
            },
            {
                "name": "PENG Jin",
                "org": ". Department of Radiation Oncology, First Hospital of Huaian,Nanjing Medical College,Huaian ,China"
            }
        ],
        "venue": "Cancer Research and Clinic",
        "year": 2007
    },
    "PPXlgVzT": {
        "id": "PPXlgVzT",
        "title": "A Review of and Reflections on Ten Years of Universities' Autonomous Enrollment",
        "abstract": "Ten years have passed since the start of universities' autonomous enrollment.During this period,the number of students enrolled autonomously gradually increased,the features of the enrollment became apparent,opinions differed on its advantages and disadvantages and much attention was paid to some hot issues.In the future,the regulatory system of universities' autonomous enrollment should be strengthened,separation between examination and admission should be promoted,the content of examinations should be optimized,the admitting method should be reformed,and supporting measures should be devised.",
        "keywords": [
            "focus of advantages and disadvantages",
            "idea of reform",
            "autonomous enrollment",
            "feature of connotation"
        ],
        "authors": [
            {
                "name": "ZHU Wei-guo",
                "org": "Jiangsu Department of Education,Nanjing ,China"
            },
            {
                "name": "ZHANG Wei",
                "org": "School of Public Administration,Nanjing University of Information Science & Technology,Nanjing ,China"
            }
        ],
        "venue": "Journal of Higher Education Management",
        "year": 2012
    },
    "prX6rSs1": {
        "id": "prX6rSs1",
        "title": "A Study on the Fairness of Entrance Opportunities of Regional Universities and Colleges in China",
        "abstract": "Fairness of entrance opportunities of universities and colleges connotes fairness of regional entrance opportunities and fairness of individual entrance opportunities.The entrance opportunities of regional universities and colleges can be represented by the admission rate in the region.The admission rate is correlative to GDP per capita.Usually,the entrance opportunities of universities and colleges are very complicated,influenced by economic development level,enrollment plan,resources of universities,scale of students sources,and level of basic education,etc..In the present system,the entrance opportunities are affected by enrollment plan significantly.Government should reduce the differences of entrance opportunities of universities and colleges among regions by way of gradual reform of system and integrated coordination,gradually change the unreasonable state of distribution structure of universities and colleges,gradually adjust the allocation of admission index,and actively promote balanced development of entrance opportunities of universities and colleges.",
        "keywords": [
            "entrance opportunities",
            "fairness of education",
            "universities and colleges"
        ],
        "authors": [
            {
                "name": "JI Li",
                "org": "Nanjing University of Information Science & Technology,Nanjing ,China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": "Nanjing University of Information Science & Technology,Nanjing ,China"
            }
        ],
        "venue": "Yuejiang Academic Journal",
        "year": 2011
    },
    "wtudjIU4": {
        "id": "wtudjIU4",
        "title": "Comparison of College Entrance Examination Evaluation system between China and America",
        "abstract": "Compared with the evaluation system of College Entrance Examination of China, this paper analyzes the \"multiple evaluation\" matriculation system of America and points out that we must combine formative evaluation with summative evaluation in order to deepen the reform on the evaluation of College Entrance Examination, make a gradual transition from single evaluation to multiple evaluation and establish the system of independent and multiple matriculation of College and effective supervision of society.",
        "keywords": [
            "College Entrance Examination",
            "evaluation system",
            "reform",
            "comparative analysis"
        ],
        "authors": [
            {
                "name": "ZHU Wei-guo",
                "org": "Jiangsu Provincial Education Examination Authority, Nanjing , China"
            },
            {
                "name": "JI Li",
                "org": "Jiangsu Provincial Education Examination Authority, Nanjing , China"
            }
        ],
        "venue": "Jiangsu Education Research",
        "year": 2010
    },
    "6S8W1VKY": {
        "id": "6S8W1VKY",
        "title": "The Key of Reform of the College and University Entrance Examination:Colleges and Universities Come to \u201cFront Desk\u201d of Enrollment",
        "abstract": "Education plan proposed the direction of reform of college and university entrance examination: \"classified exams,comprehensive evaluation,and multiple enrollment\". The key of the reform is that colleges and universities come to\"front desk\"of enrollment. It's necessary to establish the leading status of colleges and universities in terms of enrollment and clarify the rights of the independent recruitment of students,and to en- courage colleges and universities to have independent enrollment and set up a variety of platforms of enrollment. Government should play a role in ensuring fairness,policy guidance,strengthening supervision,providing in- formation service and strengthening the construction of the rule of law,and etc.",
        "keywords": [
            "college and university entrance examination reform",
            "college and university enrollment",
            "\"front desk\"of enrollment"
        ],
        "authors": [
            {
                "name": "ZHU Wei-guo",
                "org": ""
            }
        ],
        "venue": "Yuejiang Academic Journal",
        "year": 2013
    },
    "b0SAYcU0": {
        "id": "b0SAYcU0",
        "title": "The Multiple-assessment Being the Inevitable Trend of the Reform of College Entrance Examination",
        "abstract": "Multiple-assessment is an assessment system testing students' qualities by different methods as well as admitting students according to different indicators during student enrollment in the college entrance examination. Turning singe-assessment to multiple-assessment is a practical demand and inevitable tendency in the reform of system of college entrance examination. China has made some exploration in multiple-assessment system of college entrance examination. However, there are some issues existing, compared with the practical demand and advanced overseas multiple-assessment system. The overall target of the reform of system for college entrance examination is that we should gradually build and improve the assessment system of focusing on united cultural examination, with the characteristics of college self-restriction, government macro-management, and social effective supervision, which is combined with multiple examination assessment and enrollment.",
        "keywords": [
            "assessment system",
            "multiple-assessment",
            "the reform of College Entrance Examination"
        ],
        "authors": [
            {
                "name": "ZHU Wei-guo",
                "org": "Department of Education, Jiangsu Provincial Government, Nanjing , China"
            }
        ],
        "venue": "Yuejiang Academic Journal",
        "year": 2010
    },
    "zgBmY1sB": {
        "id": "zgBmY1sB",
        "title": "Interaction of Cucurbit[n]uril(n=7,8) with Sildenafil Citrate Using ~1H NMR",
        "abstract": "The host-guest chemistry of systems containing Sildenafil Citrate(denoted as SCT) and cucurbit[n]uril(denoted as CB[n],n=7,8) was investigated by 1H NMR,ESI-MS,IR,and UV-vis spectra.The results revealed that the sildenafil citrate guest and CB[n](n=7,8) host could form a stable 1 \u2236 1(molar ratio) inclusion complex,in which the position of CB[n](n=7,8) was different due to the size of their cavity.The inclusion constant of sildenafil citrate with CB[7] and CB[8] was 958 L/mol and 1530 L/mol,respectively.The binding constant which located from 102 L/mol to 103 L/mol indicates that CB[7] and CB[8] could be used as a potential slow-released agent.",
        "keywords": [
            "Inclusion complex",
            "Sildenafil sitrate",
            "Nulear magnetic resonance technique",
            "Cucurbit[n]uril",
            "Interreaction model"
        ],
        "authors": [
            {
                "name": "YANG Chun-Xue",
                "org": "Department of Chemistry,Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "ZHU Wei-Guo",
                "org": "Department of Chemistry,Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "JIANG Song",
                "org": "Department of Chemistry,Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "LI Xin-Jian",
                "org": "Department of Chemistry,Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "ZOU Da-Peng",
                "org": "Department of Chemistry,Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, Zhengzhou University,Zhengzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Analytical Chemistry",
        "year": 2012
    },
    "krF98MOY": {
        "id": "krF98MOY",
        "title": "Synthesis and Spectra Study of the Novel Higher Carbon Sugar-Derived \u03b2-Amino Alcohols",
        "abstract": "The higher carbon sugar-derived amino alcohols and their intermediates,which were potential bioactivities,were synthesized from C10 higher carbon sugar.All of these novel higher carbon sugar-derived amino alcohols were characterized by IR,ESI-MS/MS,1H NMR and 13C NMR.",
        "keywords": [
            "Spectra Study",
            "Amino Alcohols",
            "Synthesis",
            "Higher Carbon Sugar"
        ],
        "authors": [
            {
                "name": "ZOU Da-Peng",
                "org": "New Drug Research & Development Center,Zhengzhou University,Zhengzhou ,P.R.China"
            },
            {
                "name": "LIU Ning",
                "org": "New Drug Research & Development Center,Zhengzhou University,Zhengzhou ,P.R.China"
            },
            {
                "name": "WANG Rui",
                "org": "New Drug Research & Development Center,Zhengzhou University,Zhengzhou ,P.R.China"
            },
            {
                "name": "ZHU Wei-Guo",
                "org": "New Drug Research & Development Center,Zhengzhou University,Zhengzhou ,P.R.China"
            },
            {
                "name": "LIU Hong-Min",
                "org": "New Drug Research & Development Center,Zhengzhou University,Zhengzhou ,P.R.China"
            }
        ],
        "venue": "Chinese Journal of Spectroscopy Laboratory",
        "year": 2007
    },
    "Gf1RWGa0": {
        "id": "Gf1RWGa0",
        "title": "Interaction of Cucurbit[n]uril(n=6\u20148) with Buflomedil",
        "abstract": "The host-guest chemistry of the systems containing buflomedil(denoted as DLDE) and cucurbit\u00b7[n]uril(denoted as CB[n],n=6\u20148) was investigated by means of 1H NMR,ESI-MS,IR and UV-Vis spectra.The experiment results reveal that the size of the cavity of CB[n] played an important role in the interaction between the host and the guest.Buflomedil could form a stable 1:1(molar ratio) inclusion complex with CB[7] and CB[8],whereas the intereaction of buflomedil with CB[6] was very weak.The inclusion constants of buflomedil with CB[7] and CB[8] were 1.43\u00d7103 and 3.76\u00d7102 L/mol,respectively.The binding constant which located between 102\u2014103 L/mol indicates that CB[7] and CB[8] can be used as a potential slow-released agent.",
        "keywords": [
            "Inclusion complex",
            "Buflomedil",
            "Interaction model",
            "Cucurbit[n]uril",
            "1H NMR technique"
        ],
        "authors": [
            {
                "name": "YANG Xiao-Na",
                "org": "Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province,Department of Chemistry,Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "JIANG Song",
                "org": "Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province,Department of Chemistry,Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "LI Xin-Jian",
                "org": "Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province,Department of Chemistry,Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "ZHU Wei-Guo",
                "org": "Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province,Department of Chemistry,Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "KANG Jian-Xun",
                "org": "Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province,Department of Chemistry,Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "ZOU Da-Peng",
                "org": "Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province,Department of Chemistry,Zhengzhou University,Zhengzhou ,China"
            }
        ],
        "venue": "Chemical Journal of Chinese Universities",
        "year": 2010
    },
    "ZAbsuOoD": {
        "id": "ZAbsuOoD",
        "title": "Interaction between Cucurbit[n]uril(n=7,8) and Fasudil Hydrochloride Studied by NMR Spectroscopy",
        "abstract": "The host-guest chemistry of systems containing fasudil hydrochloride(FSDE) and cucurbit[n]uril(CB[n],n=7,8) was investigated by NMR,ESI-MS,UV-Vis and IR spectroscopy.The experiment results indicated that the guest fasudil hydrochloride and CB[n](n=7,8) host could form a stable 1\u22361(molar ratio) inclusion complex,in which the positions of CB[7] and CB[8] were different because of the sizes of their cavities.The inclusion constant of fasudil hydrochloride with CB[7] and CB[8] was 2 524 L/mol and 1 216 L/mol,respectively.The binding constant was in the range of 200 L/mol~10 000 L/mol,indicating that CB[7] and CB[8] could be used as possible slow-released agents.",
        "keywords": [
            "cucurbit[n]uril",
            "inclusion complex",
            "fasudil hydrochloride",
            "NMR"
        ],
        "authors": [
            {
                "name": "CHEN Xiu-li",
                "org": "Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, College of Chemistry and Molecular Engineering,Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "ZHU Wei-guo",
                "org": "Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, College of Chemistry and Molecular Engineering,Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "JIANG Song",
                "org": "Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, College of Chemistry and Molecular Engineering,Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "YANG Chun-xue",
                "org": "Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, College of Chemistry and Molecular Engineering,Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "ZOU Da-peng",
                "org": "Key Laboratory of Chemical Biology and Organic Chemistry of Henan Province, College of Chemistry and Molecular Engineering,Zhengzhou University,Zhengzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Magnetic Resonance",
        "year": 2012
    },
    "V89Np9H0": {
        "id": "V89Np9H0",
        "title": "Synthesis and Spectroscopic Properties of C10 Higher Carbon Sugar Derivatives",
        "abstract": "Ten higher carbon sugar derivatives,which are potential glycosidase inhibitors,are synthesized from 1,2-isopropylidene-5-O-benzoyl-\u03b1-D-xylofuranose.The structures of these higher carbon sugars are elucidated by means of ~1H-NMR,~(13)C-NMR,IR,ESI-MS/MS.",
        "keywords": [
            "glycosidase inhibitor",
            "spectroscopic property",
            "synthesis",
            "higher carbon sugar"
        ],
        "authors": [
            {
                "name": "Zou Dapeng",
                "org": "Department of Chemistry,Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "Zhu Weiguo",
                "org": "Department of Chemistry,Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "L\u00fc Min",
                "org": "Department of Chemistry,Zhengzhou University,Zhengzhou ,China"
            },
            {
                "name": "Liu Hongmin",
                "org": "Department of Chemistry,Zhengzhou University,Zhengzhou ,China"
            }
        ],
        "venue": "Journal of Zhengzhou University (Natural Science Edition)",
        "year": 2005
    },
    "Fu9PfVGz": {
        "id": "Fu9PfVGz",
        "title": "Feasibility and short-term efficacy of simplified intensity-modulated radiotherapy and concurrent chemotherapy for neck and upper thoracic esophageal carcinoma]",
        "abstract": "For neck and upper thoracic esophageal carcinoma, three dimensional conformal radiation therapy (3D-CRT) does not necessarily meet all clinical requirements while intensity modulated radiation therapy (IMRT) may take up a lot of labour power and material resources. This study was to explore the feasibility of simplified IMPT(sIMRT) and concurrent chemotherapy for neck and upper thoracic esophageal carcinoma, and to investigate the acute toxicities and short-term efficacy of this treatment modality.sIMRT plans were designed for 30 patients with neck and upper thoracic esophageal carcinoma. Two target volumes were defined: PTV1, which was designed to irradiate to 64 Gy (2.13 Gy x 30 fractions); PTV2, which was given to 54 Gy (1.8 Gy x 30). The sIMRT plan included five equiangular coplanar beams. All patients concurrently received DDP+5-FU regimen with radiotherapy on d1-5 and d29-33. Chemotherapy was repeated for two cycles 28 days after radiotherapy.The treatment was completed for all patients within 6 weeks, and only one patient had Grade 3 acute bronchitis. The complete response (CR) rate was 90.0% (27/30) and the partial response (PR) rate 10.0% (3/30). Overall response was 100% for esophageal lesions and the CR rate 76.5% (13/17). The PR rate was 23.5% (4/17) in lymph node lesions. The major toxicities observed were Grades I-II leukocytopenia.sIMRT can generate desirable dose distribution for neck and upper thoracic esophageal carcinoma, which is similar to sophisticated IMRT but obviously better than 3D-CRT. The short-term efficacy of sIMRT is satisfactory and its acute toxicities are tolerable.",
        "keywords": [
            "esophageal neoplasm",
            "chemotherapy",
            "efficacy",
            "combined modality",
            "simplified intensity-modulated radiotherapy"
        ],
        "authors": [
            {
                "name": "Wei-Guo Zhu",
                "org": " 1.Department of Radiation Oncology,Huai'an First People's Hospital,Huai'an,Jiangsu, 2.Huai'an Affiliated Hospital,Nanjing Medical University,Huai'an,Jiangsu,"
            },
            {
                "name": "Chang-Hua Yu",
                "org": " 1.Department of Radiation Oncology,Huai'an First People's Hospital,Huai'an,Jiangsu, 2.Huai'an Affiliated Hospital,Nanjing Medical University,Huai'an,Jiangsu,"
            },
            {
                "name": "Ji-Hua Han",
                "org": " 1.Department of Radiation Oncology,Huai'an First People's Hospital,Huai'an,Jiangsu, 2.Huai'an Affiliated Hospital,Nanjing Medical University,Huai'an,Jiangsu,"
            },
            {
                "name": "Tao Li",
                "org": " 1.Department of Radiation Oncology,Huai'an First People's Hospital,Huai'an,Jiangsu, 2.Huai'an Affiliated Hospital,Nanjing Medical University,Huai'an,Jiangsu,"
            },
            {
                "name": "Xi-Lei Zhou",
                "org": " 1.Department of Radiation Oncology,Huai'an First People's Hospital,Huai'an,Jiangsu, 2.Huai'an Affiliated Hospital,Nanjing Medical University,Huai'an,Jiangsu,"
            },
            {
                "name": "Guang-Zhou Tao",
                "org": " 1.Department of Radiation Oncology,Huai'an First People's Hospital,Huai'an,Jiangsu, 2.Huai'an Affiliated Hospital,Nanjing Medical University,Huai'an,Jiangsu,"
            }
        ],
        "venue": "Ai zheng = Aizheng = Chinese journal of cancer",
        "year": 2009
    },
    "HMKRoqiK": {
        "id": "HMKRoqiK",
        "title": "Efficacy analysis of simplified intensity-modulated radiotherapy with high or conventional dose and concurrent chemotherapy for patients with neck and upper thoracic esophageal carcinoma.",
        "abstract": "For patients with neck and upper thoracic esophageal carcinoma, it is difficult to control lymph node metastases with conventional dose therapy. In this study, we assessed the feasibility of simplified intensity-modulated radiotherapy (sIMRT) and concurrent chemotherapy for 44 patients and boosted high-dose to metastatic lymph nodes.Three radiation treatment volumes were defined: PGTVnd, with which 68.1 Gy was delivered in high dose group (hsIMRT group), and 60 Gy in the conventional dose group (csIMRT group); PTV1, featuring 63.9 Gy in the hsIMRT group and 60Gy in the csIMRT group; PTV2, with 54 Gy given to both groups. The sIMRT plan included 5 equi-angular coplanar beams. All patients received the cisplatin and 5-FU regimen concurrently with radiotherapy. The treatment was completed within six weeks and one case with grade three acute bronchitis was observed in hsIMRT group. For esophageal lesions, 80% complete response (CR) and 20% partial response (PR) rates were found in the hsIMRT group, and 79.2% CR, with 20.8% PR, in the csIMRT group; for lymph node lesions, 75% CR and 25% PR rates were observed in the hsIMRT group, with 45.8% and 37.5% respectively in the csIMRT group (P <0.05). The differences in 1-, 2- and 3-year relapse-free survival rates were all statistically significant (P <0.05). The major toxicity observed in both groups was Grade I~II leucopenia. sIMRT can generate a desirable dose distribution in treatment of neck and upper thoracic esophageal carcinoma with a better short-term efficacy. Boosted high dosing to metastatic lymph nodes can increase the relapse-free survival rate.",
        "keywords": [
            "prognosis",
            "chemotherapy",
            "modulated radiotherapy",
            "simplified intensity",
            "esophageal carcinoma"
        ],
        "authors": [
            {
                "name": "Wei-Guo Zhu",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Ke Zhou",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Chang-Hua Yu",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Ji-Hua Han",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Tao Li",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Xiao-Fei Chen",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            }
        ],
        "venue": "Asian Pacific journal of cancer prevention : APJCP",
        "year": 2012
    },
    "accJbtwN": {
        "id": "accJbtwN",
        "title": "A randomized, controlled, multicenter study comparing intensity-modulated radiotherapy plus concurrent chemotherapy with chemotherapy alone in gastric cancer patients with D2 resection.",
        "abstract": "The role of postoperative chemoradiotherapy in the treatment of patients with gastric cancer with D2 lymph node curative dissection is not well established. In this study, we compared postoperative intensity-modulated radiotherapy plus chemotherapy (IMRT-C) with chemotherapy-only in this patient population.We randomly assigned patients with D2 lymph node dissection in gastric cancer to IMRT-C or chemotherapy-only groups. The adjuvant IMRT-C consisted of 400 mg of fluorouracil per square meter of body-surface area per day plus 20mg of leucovorin per square meter of body-surface area per day for 5 days, followed by 45 Gy of IMRT for 5 weeks, with fluorouracil and leucovorin on the first 4 and the last 3 days of radiotherapy. Two 5-day cycles of fluorouracil and leucovorin were given 4 weeks after the completion of IMRT. Chemotherapy-only group was given the same chemotherapy regimens as IMRT-C group.The median overall survival (OS) in the chemotherapy-only group was 48 months, as compared with 58 months in the IMRT-C group; the hazard ratio for death was 1.24 (95% confidence interval, 0.94-1.65; P=0.122). IMRT-C was associated with increases in the median duration of recurrence-free survival (RFS) (36 months vs. 50 months), the hazard ratio for recurrence was 1.35 (95% confidence interval, 1.03-1.78; P=0.029). COX multivariate regression analysis showed that lymph node metastasis and TNM stage were both the independent prognostic factors. Rates of all grade adverse events were similar in the two treatment groups.IMRT-C improved RFS, but did not significantly improve OS among patients with D2 lymph node dissection in gastric cancer. Using IMRT plus chemotherapy was feasible and well tolerated in patients with gastric cancer after D2 resection.",
        "keywords": [
            "intensity modulated radiotherapy (imrt)",
            "prognosis",
            "d2 resection",
            "chemotherapy",
            "gastric cancer"
        ],
        "authors": [
            {
                "name": "Wei-guo Zhu",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Da-fu Xua",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Jun Pu",
                "org": "People Hospital of Lianshui County(Lianshui County People's Hospital,People Hospital of Lianshui County),,China"
            },
            {
                "name": "Cheng-dong Zong",
                "org": "Oncology Hospital of huai'An(Oncology Hospital of huai'An),,China"
            },
            {
                "name": "Tao Li",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Guang-zhou Tao",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Fu-zhi Ji",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Xi-lei Zhou",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Ji-hua Han",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Cheng-shi Wang",
                "org": "People Hospital of Lianshui County(Lianshui County People's Hospital,People Hospital of Lianshui County),,China"
            },
            {
                "name": "Chang-hua Yu",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Jiang-guo Yi",
                "org": "Oncology Hospital of huai'An(Oncology Hospital of huai'An),,China"
            },
            {
                "name": "Xi-long Su",
                "org": "Huai'An No 2 People's Hospital(Huai'An No 2 People's Hospital),,China"
            },
            {
                "name": "Jin-xia Ding",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            }
        ],
        "venue": "Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology",
        "year": 2012
    },
    "sawYynLA": {
        "id": "sawYynLA",
        "title": "A randomized controlled study of single-agent cisplatin and radiotherapy versus docetaxel/cisplatin and radiotherapy in high-risk early-stage cervical cancer after radical surgery.",
        "abstract": "This study explored whether docetaxel/cisplatin and radiotherapy (TP-R) increases overall survival (OS) and recurrence-free survival (RFS) compared to single-agent cisplatin and radiotherapy (C-R) in patients with high-risk early-stage cervical cancer post surgery.Patients with clinical stage IB and IIA carcinoma of the cervix, initially treated with radical hysterectomy and pelvic lymphadenectomy, and who had positive pelvic lymph nodes and/or positive margins and/or the diameter of the primary tumor \u22654 cm and/or depth of interstitial infiltration \u22651/2 and/or lymphovascular space invasion were eligible for this study. Patients were randomized to receive C-R or TP-R. Radiotherapy in both groups was external radiation (46-54 Gy) followed by high-dose rate brachytherapy (12-24 Gy). Patients were given cisplatin (40 mg/m(2)) every week for five cycles (C-R group) or docetaxel (30 mg/m(2)) and cisplatin (30 mg/m(2)) every week for five cycles (TP-R group).Between 2003 and 2008, 320 patients were entered onto the study. Final analyses included 285 patients. One hundred and forty patients comprised the C-R group and 145 were in the TP-R group. The 5-year OS were 74.3 % in the C-R group and 82.8 % in the TP-R group. The hazard ratio (HR) for death was 0.65 in the TP-R group (95 % CI: 0.39-1.09, P = 0.098). The RFS were 69.3 % in the C-R group and 79.3 % in the TP-R group, and the HR for recurrence was 0.64 in the TP-R group (95 % CI: 0.40-1.03, P = 0.061). Recurrence rates were similar in both groups (27 in the C-R group and 18 in the TP-R group, P = 0.112). The seriousness of late side effects was similar in the two groups, with a higher rate of reversible hematological effects in the TP-R group.Compared with single-agent cisplatin and radiotherapy, docetaxel/cisplatin in combination with radiotherapy does not increase OS but has the trend of increasing RFS in patients with high-risk early-stage cervical cancer. However, docetaxel/cisplatin in combination with radiotherapy is associated with a higher incidence of side effects, this effect was reversible, and the incidence of late side effects was similar in the two treatment groups.",
        "keywords": [
            "Early-stage cervical cancer",
            "Post surgery",
            "Radiotherapy",
            "Chemotherapy",
            "High-risk factor"
        ],
        "authors": [
            {
                "name": "Juan Pu",
                "org": "People Hospital of Lianshui County(Lianshui County People's Hospital,People Hospital of Lianshui County),,China"
            },
            {
                "name": "Shan-shan Qin",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Jin-xia Ding",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Yan Zhang",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Wei-guo Zhu",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Chang-hua Yu",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Tao Li",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Guang-zhou Tao",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Fu-zhi Ji",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Xi-lei Zhou",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Ji-hua Han",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Ya-lin Ji",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Jun-xia Sun",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            }
        ],
        "venue": "Journal of cancer research and clinical oncology",
        "year": 2013
    },
    "ghMBokUW": {
        "id": "ghMBokUW",
        "title": "Correlation of hedgehog signal activation with chemoradiotherapy sensitivity and survival in esophageal squamous cell carcinomas.",
        "abstract": "To investigate the significance of hedgehog signaling pathway in chemoradiotherapy sensitivity and its effect on the prognosis of esophageal squamous cell carcinoma.In the present study, we used the method of immunohistochemistry to examine the expression status of two hedgehog components, PTCH1 and glioma-associated oncogene GLI-1, in 100 pre-treated biopsy specimens of esophageal squamous cell carcinoma patients treated with definitive chemoradiotherapy.We find that high levels of PTCH1 and GLI-1 were detected in 76.0 and 72.0% of esophageal squamous cell carcinoma, respectively. Significant associations of high PTCH1 and GLI-1 expression with large tumor size (both P = 0.01), locoregional progression (P= 0.001 and 0.003, respectively) and the lack of complete response to chemoradiotherapy (P= 0.008 and 0.01, respectively) were observed. Univariate analysis revealed that high PTCH1 and GLI-1 expression was associated with poor locoregional progression-free survival, distant progression-free survival and overall survival. Furthermore, esophageal squamous cell carcinoma patients with high PTCH1 and GLI-1 expression have the shorter survival time than the subgroups with negative and low PTCH1 and GLI-1 expression. In multivariate analysis, PTCH1 and GLI-1 expression status were both evaluated as independent prognostic factors for locoregional progression-free survival, distant progression-free survival and overall survival.These findings suggest an important role for the activation of hedgehog signaling in esophageal squamous cell carcinoma progression and that PTCH1 and GLI-1 expression may be significantly associated with esophageal squamous cell carcinoma resistance to chemoradiotherapy.",
        "keywords": [
            "esophageal squamous cell carcinoma",
            "prognosis",
            "hedgehog signal pathway",
            "gli-1",
            "ptch1"
        ],
        "authors": [
            {
                "name": "Weiguo Zhu",
                "org": "Hospital of Nanjing Medical University(Hospital of Nanjing Medical University,First Affiliated Hospital of Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Zhenbin You",
                "org": "Hospital of Nanjing Medical University(Hospital of Nanjing Medical University,First Affiliated Hospital of Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Tao Li",
                "org": "Hospital of Nanjing Medical University(Hospital of Nanjing Medical University,First Affiliated Hospital of Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Changhua Yu",
                "org": "Hospital of Nanjing Medical University(Hospital of Nanjing Medical University,First Affiliated Hospital of Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Guangzhou Tao",
                "org": "Hospital of Nanjing Medical University(Hospital of Nanjing Medical University,First Affiliated Hospital of Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Mingli Hu",
                "org": "Hospital of Nanjing Medical University(Hospital of Nanjing Medical University,First Affiliated Hospital of Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Xiaofei Chen",
                "org": "Hospital of Nanjing Medical University(Hospital of Nanjing Medical University,First Affiliated Hospital of Nanjing Medical University),Nanjing,China"
            }
        ],
        "venue": "Japanese journal of clinical oncology",
        "year": 2011
    },
    "F8iOYe3I": {
        "id": "F8iOYe3I",
        "title": "Intensity-modulated radiotherapy combined with chemotherapy for the treatment of gastric cancer patients after standard D1/D2 surgery.",
        "abstract": "The purpose of the current study is to evaluate the efficacy and complications of concurrent chemoradiotherapy (CCRT) for the treatment of gastric cancer patients after D1/D2 surgery.Sixty-eight untreated gastric cancer patients (T3/T4 and/or N+) were enrolled. After surgery, they were randomized into two groups: the CCRT group and the single chemotherapy group. Radiotherapy patients were treated according to the Intergroup 0116 guidelines. The chemotherapy consisted of continuously administered 5-fluorouracil (5-FU) and tetrahydrofolic acid (LV). The CCRT began 28 days after the first cycle of chemotherapy, and chemotherapy was given within the first four and last three days during the CCRT period, at a radiation dosage of 45 Gy/25 f, i.e., 1.8 Gy 5 times per week. Two cycles of the same chemotherapy were administrated 1 month after the radiotherapy. Five cycles of 5-FU and LV were applied to CG.One-, two-, and three-year survival rates were 85.9, 73.4, and 67.7%, respectively, in the CCRT group and 68.0, 50.0, and 44.1%, in the single chemotherapy group (P < 0.05). The corresponding disease-free survival rates were 73.5, 64.7, and 55.8% in the CCRT group and 61.8, 38.2, and 29.4% in the single chemotherapy group (P < 0.05). The major side effects were gastrointestinal reactions and neutrocytopenia. In both the CCRT and single chemotherapy groups, the incidence of these side effects was 73.5% (25/34) and 44.1% (15/34) (P < 0.05) for Grade I and Grade II anorexia, 82.35% (28/34) and 73.5% (25/34) (P > 0.05) for nausea and vomiting, and 70.6% (24/34) and 44.1% (15/34) (P < 0.05) for neutrocytopenia, respectively. The other indices showed no significant differences.Our findings indicate that CCRT can increase the one-, two-, and three-year total survival rates, as well as the disease-free survival rates of gastric cancer patients (T3/T4 and/or N+) who have been initially treated with surgery. The major adverse reactions were Grade I and Grade II nausea and vomiting, as well as myelosuppression. CCRT is well tolerated.",
        "keywords": [
            "Gastric cancer",
            "Chemotherapy",
            "Intensity-modulated radiotherapy",
            "Concurrent chemoradiotherapy",
            "Surgery"
        ],
        "authors": [
            {
                "name": "Changhua Yu",
                "org": "Huai'An First People's Hospital(Huai'an First People's Hospital,First People's Hospital in Huai'an,Huai'An First People's Hospital),,China"
            },
            {
                "name": "Ren Yu",
                "org": "Huai'An First People's Hospital(Huai'an First People's Hospital,First People's Hospital in Huai'an,Huai'An First People's Hospital),,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Huai'An First People's Hospital(Huai'an First People's Hospital,First People's Hospital in Huai'an,Huai'An First People's Hospital),,China"
            },
            {
                "name": "Yaqi Song",
                "org": "Huai'An First People's Hospital(Huai'an First People's Hospital,First People's Hospital in Huai'an,Huai'An First People's Hospital),,China"
            },
            {
                "name": "Tao Li",
                "org": "Huai'An First People's Hospital(Huai'an First People's Hospital,First People's Hospital in Huai'an,Huai'An First People's Hospital),,China"
            }
        ],
        "venue": "Journal of cancer research and clinical oncology",
        "year": 2012
    },
    "RZXCfOao": {
        "id": "RZXCfOao",
        "title": "Loss of Protein Tyrosine Phosphatase Receptor J Expression Predicts an Aggressive Clinical Course in Patients with Esophageal Squamous Cell Carcinoma",
        "abstract": "Abstract Protein Tyrosine Phosphatase Receptor J (PTPRJ) has been reported to be a tumor suppressor in various human cancers. The aim of this study was to investigate the clinical significance of PTPRJ in ESCC patients and its effects on biological behaviors of ESCC cells. PTPRJ expression, at mRNA and protein levels, were respectively detected by quantitative real-time PCR, western blot and immunohistochemistry, based on 106 newly diagnosed ESCC patients. The associations between PTPRJ expression and clinicopathological characteristics of ESCC patients were statistically analyzed. Then, the effects of PTPRJ in migration and invasion were determined by wound healing and transwell assays based on ESCC cell line transfected with siRNA or expression vector of PTPRJ. Expression of PTPRJ at mRNA and protein levels were both significantly lower in ESCC tissues than those in normal esophageal mucosa. Immunohistochemistry showed that PTPRJ protein was localized in the cytoplasm of cancer cells in ESCC tissues. In addition, PTPRJ downregulation was found to be closely correlated with advanced tumor stage (P = 0.01) and poor differentiation (P = 0.03). Moreover, knockdown of PTPRJ in KYSE510 cells could significantly promote cell migration and invasion (both P < 0.05), which were reversed by the restoration of PTPRJ expression in vitro (both P < 0.05). Our data offer the convincing evidence that loss of PTPRJ expression may predict an aggressive clinical course in ESCC patients. PTPRJ may function as a tumor suppressor and play an important role in the regulation of ESCC cell motility, suggesting its potentials as a therapeutic agent for human ESCC.",
        "keywords": [
            "Esophageal squamous cell carcinoma",
            "Invasion",
            "Migration",
            "Progression",
            "Protein tyrosine phosphatase receptor J"
        ],
        "authors": [
            {
                "name": "Dongfeng Qiao",
                "org": "Department of Radiotherapy Pathology, People\u2019s Hospital of Lianshui County, Lianshui, 223400, China"
            },
            {
                "name": "Ming Li",
                "org": "Department of Radiotherapy Pathology, People\u2019s Hospital of Xuyi County, Xuyi, 211700, China"
            },
            {
                "name": "Juan Pu",
                "org": "Department of Radiotherapy Pathology, People\u2019s Hospital of Lianshui County, Lianshui, 223400, China"
            },
            {
                "name": "Wanwei Wang",
                "org": "Department of Radiotherapy Pathology, People\u2019s Hospital of Lianshui County, Lianshui, 223400, China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Radiotherapy Oncology, Huai\u2019an First People\u2019s Hospital, Nanjing Medical University, Huai\u2019an, 223300, China"
            },
            {
                "name": "hongmao liu",
                "org": "Department of Pathology, Huai\u2019an First People\u2019s Hospital, Nanjing Medical University, Huai\u2019an, 223300, China"
            }
        ],
        "venue": "Pathology & Oncology Research",
        "year": 2015
    },
    "JqDXxgd5": {
        "id": "JqDXxgd5",
        "title": "Elevated Nectin-2 expression is involved in esophageal squamous cell carcinoma by promoting cell migration and invasion.",
        "abstract": "Nectin-2 is overexpressed in cancer cells and is associated with poor prognosis in patients with various types of cancers. However, its involvement in esophageal squamous cell carcinoma (ESCC) remains unknown. The present study aimed to investigate the expression pattern of Nectin-2, its clinical significance and its roles in the malignant phenotypes of ESCC. Expression levels of Nectin-2 mRNA and protein were respectively detected by reverse transcription-quantitative polymerase chain reaction, western blotting and immunohistochemistry, based on 106 newly diagnosed ESCC patients. The associations between Nectin-2 expression and clinicopathological characteristics of ESCC patients were statistically analyzed. The effects of Nectin-2 in migration and invasion were then determined by wound healing and Transwell assays performed using ESCC cell lines (ECA109 and KYSE510) transfected with small interfering (si) RNA against Nectin-2. It was found that Nectin-2 expression was significantly elevated at the mRNA and protein levels in ESCC tissues, compared with the normal esophageal mucosa (P<0.001). Nectin-2-positive immunoreactivity was mainly localized in the cytoplasm of cancer cells in ESCC tissues. In addition, the expression levels of Nectin-2 protein in ESCC tissues with advanced tumor stage (P=0.006) and poor differentiation (P=0.02) were increased compared with patients with early tumor stage and well to moderate differentiation. Additionally, knockdown of Nectin-2 in the 2 ESCC cell lines could effectively suppress the cell migration and invasion abilities (P<0.05). In conclusion, these findings revealed that Nectin-2 is generally overexpressed in ESCC and associated with aggressive cancer progression. The present data also indicated that the silencing of Nectin-2 with siRNA in ESCC cells may inhibit cell malignant biological properties, indicating its potential as a potential marker or a therapeutic target for ESCC.",
        "keywords": [
            "Nectin-2",
            "esophageal squamous cell carcinoma",
            "invasion",
            "migration",
            "progression"
        ],
        "authors": [
            {
                "name": "Ming Li",
                "org": "Department of Radiotherapy Pathology, People's Hospital of Xuyi County, Huai'an, Jiangsu 211700, P.R. China."
            },
            {
                "name": "Dongfeng Qiao",
                "org": "Department of Radiotherapy Pathology, People's Hospital of Lianshui County, Huai'an, Jiangsu 223400, P.R. China."
            },
            {
                "name": "Juan Pu",
                "org": "Department of Radiotherapy Pathology, People's Hospital of Lianshui County, Huai'an, Jiangsu 223400, P.R. China."
            },
            {
                "name": "Wanwei Wang",
                "org": "Department of Radiotherapy Pathology, People's Hospital of Lianshui County, Huai'an, Jiangsu 223400, P.R. China."
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Radiotherapy Oncology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China."
            },
            {
                "name": "Haiyan Liu",
                "org": "Department of Pathology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China."
            }
        ],
        "venue": "Oncology letters",
        "year": 2018
    },
    "KELlOmf9": {
        "id": "KELlOmf9",
        "title": "A multi-center, randomized, prospective study evaluating the optimal radiation dose of definitive concurrent chemoradiation for inoperable esophageal squamous cell carcinoma.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yanjun Xu",
                "org": "Zhejiang Cancer Hospital, Hangzhou, China;"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Huai'an First People's Hospital, Huai'an, China;"
            },
            {
                "name": "Xiao Zheng",
                "org": "Zhejiang Cancer Hospital, Hangzhou, China;"
            },
            {
                "name": "Wanwei Wang",
                "org": "Huai'an First People's Hospital, Huai'an, China;"
            },
            {
                "name": "Jiancheng Li",
                "org": "Fujian Cancer Hospital, Fuzhou, China;"
            },
            {
                "name": "Rong Huang",
                "org": "Foshan First People's Hospital, Foshan, China;"
            },
            {
                "name": "Han He",
                "org": "Foshan First People's Hospital, Foshan, China;"
            },
            {
                "name": "Jianxiang Chen",
                "org": "Zhejiang Cancer Hospital, Hangzhou, China;"
            },
            {
                "name": "Liping Liu",
                "org": "Jining First People's Hospital, Jining, China;"
            },
            {
                "name": "Sun Z",
                "org": "Jining First People's Hospital, Jining, China;"
            },
            {
                "name": "Xinmei Yang",
                "org": "Jiaxing First People's Hospital, Jiaxing, China;"
            },
            {
                "name": "Huijuan He",
                "org": "Quzhou People's Hospital, Quzhou, China;"
            },
            {
                "name": "Ming Zeng",
                "org": "Sichuan Provincial People's Hospital/Sichuan Academy of Medical Science, Chengdu, China;"
            },
            {
                "name": "Juan Pu",
                "org": "Lianshui People's Hospital, Lianshui, China;"
            },
            {
                "name": "Wangyuan Hu",
                "org": "Jinhua Central Hospital, Jinhua, China;"
            },
            {
                "name": "Yong Bao",
                "org": "Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China;"
            },
            {
                "name": "Zhigang Liu",
                "org": "Hunan Cancer Hospital, Changsha, China;"
            },
            {
                "name": "Jun Ma",
                "org": "Anhui Provincial Hospital, Hefei, China;"
            },
            {
                "name": "Ming Chen",
                "org": "Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, China;"
            }
        ],
        "venue": "Journal of Clinical Oncology",
        "year": 2018
    },
    "8bDNbfwI": {
        "id": "8bDNbfwI",
        "title": "Survival benefit of radiotherapy to patients with small cell esophagus carcinoma: an analysis of Surveillance Epidemiology and End Results (SEER) data.",
        "abstract": "Stage, age, year, and RT are independent prognostic factors of SCEC. Survival benefit of RT exists in any disease stage, but is only statistically significant in localized stage of SCEC.",
        "keywords": [
            "esophageal cancer",
            "prognostic factors",
            "radiotherapy",
            "small cell carcinoma",
            "stage"
        ],
        "authors": [
            {
                "name": "Yaqi Song",
                "org": "Department of Radiation Oncology, Huai'an First People's Hospital, Nanjing Medical University, Nanjing, Huai'an 223300, China."
            },
            {
                "name": "Wanwei Wang",
                "org": "Department of Radiation Oncology, Huai'an First People's Hospital, Nanjing Medical University, Nanjing, Huai'an 223300, China."
            },
            {
                "name": "Guangzhou Tao",
                "org": "Department of Radiation Oncology, Huai'an First People's Hospital, Nanjing Medical University, Nanjing, Huai'an 223300, China."
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Radiation Oncology, Huai'an First People's Hospital, Nanjing Medical University, Nanjing, Huai'an 223300, China."
            },
            {
                "name": "Xilei Zhou",
                "org": "Department of Radiation Oncology, Huai'an First People's Hospital, Nanjing Medical University, Nanjing, Huai'an 223300, China."
            },
            {
                "name": "Peng Pan",
                "org": "Department of Radiation Oncology, Huai'an First People's Hospital, Nanjing Medical University, Nanjing, Huai'an 223300, China."
            }
        ],
        "venue": "Oncotarget",
        "year": 2016
    },
    "n3zfX3h7": {
        "id": "n3zfX3h7",
        "title": "A Prospective, Randomized, Multi-Center, Phase III Study Evaluating ofOptimal Radiation Dose for Definitive Concurrent Chemoradiation forInoperable Esophageal Carcinoma",
        "abstract": "This prospective clinical trial summary provides the background and rationale for evaluating optimal radiation dose for definitive concurrent chemo-radiation for inoperable esophageal carcinoma. We designed the multi-center clinical trial comparing the efficacy of high dose group (60 Gy/30F) with low dose group (50 Gy/25F) concurrent with weekly chemotherapy using 3D-CRT or IMRT technology for esophageal carcinoma. The primary outcome is local/ regional progression-free survival, and secondary outcomes include Overall survival; local control rate; patterns of treatment failure; toxicity; radiation-related advent events.",
        "keywords": "",
        "authors": [
            {
                "name": "Yujin Xu",
                "org": ""
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            },
            {
                "name": "Jiancheng Li",
                "org": ""
            },
            {
                "name": "Zhongwen Sun",
                "org": ""
            },
            {
                "name": "Xiao Zheng",
                "org": ""
            },
            {
                "name": "Ming Chen",
                "org": ""
            }
        ],
        "venue": "Journal of clinical trials",
        "year": 2016
    },
    "8fvyzm1p": {
        "id": "8fvyzm1p",
        "title": "Feasibility and short-term efficacy of simplified intensity-modulated radiotherapy and concurrent chemotherapy for neck and upper thoracic esophageal carcinoma",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "changhua yu",
                "org": ""
            },
            {
                "name": "jihua han",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            },
            {
                "name": "tao li",
                "org": ""
            },
            {
                "name": "xilei zhou",
                "org": ""
            },
            {
                "name": "guangzhou tao",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2009
    },
    "3MAZhGqA": {
        "id": "3MAZhGqA",
        "title": "Intensity-modulated radiotherapy combined with chemotherapy for the treatment of gastric cancer patients after standard D1/D2 surgery",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "tao li",
                "org": ""
            },
            {
                "name": "yaqi song",
                "org": ""
            },
            {
                "name": "weiguo zhu",
                "org": ""
            },
            {
                "name": "ren yu",
                "org": ""
            },
            {
                "name": "changhua yu",
                "org": ""
            }
        ],
        "venue": "Journal of Cancer Research and Clinical Oncology",
        "year": 2011
    },
    "6o0LAuCM": {
        "id": "6o0LAuCM",
        "title": "Dosimetric analysis of intensity-modulated radiotherapy in cervical carcinoma",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Chang-hua Yu",
                "org": ""
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            },
            {
                "name": "Ya-ling Ji",
                "org": ""
            },
            {
                "name": "Peng Pan",
                "org": ""
            },
            {
                "name": "Ji-hua Han",
                "org": ""
            },
            {
                "name": "Tao Li",
                "org": ""
            }
        ],
        "venue": "Cancer Research and Clinic",
        "year": 2012
    },
    "QHbqdvgh": {
        "id": "QHbqdvgh",
        "title": "cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation.",
        "abstract": "The capsaicin receptor, VR1 (also known as TRPV1), is a ligand-gated ion channel expressed on nociceptive sensory neurons that responds to noxious thermal and chemical stimuli. Capsaicin responses in sensory neurons exhibit robust potentiation by cAMP-dependent protein kinase (PKA). In this study, we demonstrate that PKA reduces VR1 desensitization and directly phosphorylates VR1. In vitro phosphorylation, phosphopeptide mapping, and protein sequencing of VR1 cytoplasmic domains delineate several candidate PKA phosphorylation sites. Electrophysiological analysis of phosphorylation site mutants clearly pinpoints Ser116 as the residue responsible for PKA-dependent modulation of VR1. Given the significant roles of VR1 and PKA in inflammatory pain hypersensitivity, VR1 phosphorylation at Ser116 by PKA may represent an important molecular mechanism involved in the regulation of VR1 function after tissue injury.",
        "keywords": [
            "molecular mechanics",
            "protein sequence",
            "camp dependent protein kinase",
            "ligand gated ion channel"
        ],
        "authors": [
            {
                "name": "Gautam Bhave",
                "org": "Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 USA"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Cell and Molecular Physiology and The Neuroscience Center, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599 USA"
            },
            {
                "name": "Haibin Wang",
                "org": "Department of Cell and Molecular Physiology and The Neuroscience Center, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599 USA"
            },
            {
                "name": "D J Brasier",
                "org": "Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 USA"
            },
            {
                "name": "Gerry S Oxford",
                "org": "Department of Cell and Molecular Physiology and The Neuroscience Center, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599 USA"
            },
            {
                "name": "Robert W Gereau",
                "org": ""
            }
        ],
        "venue": "Neuron",
        "year": 2002
    },
    "oImhzqSG": {
        "id": "oImhzqSG",
        "title": "From The Cover: Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Gautam Bhave",
                "org": ""
            },
            {
                "name": "Hui-Juan Hu",
                "org": ""
            },
            {
                "name": "Kathi S. Glauner",
                "org": ""
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            },
            {
                "name": "Haibin Wang",
                "org": ""
            },
            {
                "name": "D. J. Brasier",
                "org": ""
            },
            {
                "name": "Gerry S. Oxford",
                "org": ""
            },
            {
                "name": "Robert W. Gereau",
                "org": ""
            }
        ],
        "venue": "Proceedings of The National Academy of Sciences",
        "year": 2003
    },
    "l4D5lUgX": {
        "id": "l4D5lUgX",
        "title": "Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1).",
        "abstract": "Protein kinase C (PKC) modulates the function of the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). This modulation manifests as increased current when the channel is activated by capsaicin. In addition, studies have suggested that phosphorylation by PKC might directly gate the channel, because PKC-activating phorbol esters induce TRPV1 currents in the absence of applied ligands. To test whether PKC both modulates and gates the TRPV1 function by direct phosphorylation, we used direct sequencing to determine the major sites of PKC phosphorylation on TRPV1 intracellular domains. We then tested the ability of the PKC-activating phorbol 12-myristate 13-acetate (PMA) to potentiate capsaicin-induced currents and to directly gate TRPV1. We found that mutation of S800 to alanine significantly reduced the PMA-induced enhancement of capsaicin-evoked currents and the direct activation of TRPV1 by PMA. Mutation of S502 to alanine reduced PMA enhancement of capsaicin-evoked currents, but had no effect on direct activation of TRPV1 by PMA. Conversely, mutation of T704 to alanine had no effect on PMA enhancement of capsaicin-evoked currents but dramatically reduced direct activation of TRPV1 by PMA. These results, combined with pharmacological studies showing that inactive phorbol esters also weakly activate TRPV1, suggest that PKC-mediated phosphorylation modulates TRPV1 but does not directly gate the channel. Rather, currents induced by phorbol esters result from the combination of a weak direct ligand-like activation of TRPV1 and the phosphorylation-induced enhancement of the TRPV1 function. Furthermore, modulation of the TRPV1 function by PKC appears to involve distinct phosphorylation sites depending on the mechanism of channel activation.",
        "keywords": [
            "transfection",
            "protein kinase c",
            "phosphorylation",
            "cos cells",
            "kinetics",
            "enzyme activation"
        ],
        "authors": [
            {
                "name": "Gautam Bhave",
                "org": ""
            },
            {
                "name": "Hui-Juan Hu",
                "org": ""
            },
            {
                "name": "Kathi S Glauner",
                "org": ""
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            },
            {
                "name": "Haibin Wang",
                "org": ""
            },
            {
                "name": "D J Brasier",
                "org": ""
            },
            {
                "name": "Gerry S Oxford",
                "org": ""
            },
            {
                "name": "Robert W Gereau",
                "org": ""
            }
        ],
        "venue": "Proceedings of the National Academy of Sciences of the United States of America",
        "year": 2003
    },
    "HMtTMvIk": {
        "id": "HMtTMvIk",
        "title": "Differential gene expression of neonatal and adult DRG neurons correlates with the differential sensitization of TRPV1 responses to nerve growth factor.",
        "abstract": "Cultures of neonatal and adult dorsal root ganglion (DRG) neurons are commonly used in in vitro models to study the ion channels and signaling events associated with peripheral sensation under various conditions. Differential responsiveness between neonatal and adult DRG neurons to physiological or pathological stimuli suggests potential differences in their gene expression profiles. We performed a microarray analysis of cultured adult and neonatal rat DRG neurons, which revealed distinct gene expression profiles especially of ion channels and signaling molecules at the genomic level. For example, Ca(2+)-stimulated adenylyl cyclase (AC) isoforms AC3 and AC8, PKC\u03b4 and CaMKII\u03b1, the voltage-gated sodium channel \u03b21 and \u03b24, and potassium channels K(v)1.1, K(v)3.2, K(v)4.1, K(v)9.1, K(v)9.3, K(ir)3.4, K(ir)7.1, K(2P)1.1/TWIK-1 had significantly higher mRNA expression in adult rat DRG neurons, while Ca(2+)-inhibited AC5 and AC6, sodium channel Na(v)1.3 \u03b1 subunit, potassium channels K(ir)6.1, K(2P)10.1/TREK-2, calcium channel Ca(v)2.2 \u03b11 subunit, and its auxiliary subunits \u03b21 and \u03b23 were conversely down regulated in adult neurons. Importantly, higher adult neuron expression of ERK1/2, PI3K/P110\u03b1, but not of TRPV1 and TrkA, was found and confirmed by PCR and western blot. These latter findings are consistent with the key role of ERK and PI3K signaling in sensitization of TRPV1 by NGF and may explain our previously published observation that adult, but not neonatal, rat DRG neurons are sensitized by NGF.",
        "keywords": [
            "voltage gated sodium channel",
            "calcium channel",
            "ion channel",
            "gene expression regulation",
            "potassium channel",
            "sodium channel",
            "gene expression profiling",
            "ion channels",
            "signal transduction",
            "potential difference",
            "microarray analysis",
            "microarray"
        ],
        "authors": [
            {
                "name": "Weiguo Zhu",
                "org": ""
            },
            {
                "name": "Gerry S Oxford",
                "org": "Stark Neuroscience Research Institute and Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202"
            }
        ],
        "venue": "Neuroscience letters",
        "year": 2011
    },
    "iwopzAEK": {
        "id": "iwopzAEK",
        "title": "A developmental switch in acute sensitization of small dorsal root ganglion (DRG) neurons to capsaicin or noxious heating by NGF.",
        "abstract": "Using dissociated rat dorsal root ganglion (DRG) neurons, we have explored the ability of nerve growth factor (NGF) to acutely (within minutes) sensitize responses of nociceptors to capsaicin or noxious heat during postnatal development. While robust sensitization of noxious heat or capsaicin responses by NGF is observed in adult DRG neurons, responses to such stimuli in trkA-positive neurons from early postnatal animals are not sensitized by NGF. Neurons acquire sensitivity to the hyperalgesic effects of NGF between postnatal days 4 and 10 (P4-P10). In contrast to NGF, bradykinin sensitizes responses to noxious heat in both adult and neonatal DRG neurons. These observations suggest a developmental switch in signal transduction cascades linking trkA receptors to hyperalgesia during postnatal development and differences in the signaling pathways mediating bradykinin- and NGF-induced sensitization.",
        "keywords": [],
        "authors": [
            {
                "name": "Weiguo Zhu",
                "org": "Stark Neurosciences Research Institute|Indiana University|School of Medicine"
            },
            {
                "name": "Sam M. Galoyan",
                "org": "Department of Neurobiology and Behavior|State University of New York at Stony Brook|Stark Neurosciences Research Institute|Indiana University|School of Medicine"
            },
            {
                "name": "Jeffrey C. Petruska",
                "org": "Department of Neurobiology and Behavior|State University of New York at Stony Brook|Stark Neurosciences Research Institute|Indiana University|School of Medicine"
            },
            {
                "name": "Gerry S. Oxford",
                "org": "Stark Neurosciences Research Institute|Indiana University|School of Medicine"
            },
            {
                "name": "Lorne M. Mendell",
                "org": "Department of Neurobiology and Behavior|State University of New York at Stony Brook|Stark Neurosciences Research Institute|Indiana University|School of Medicine"
            },
            {
                "name": "Gerry S. Oxford",
                "org": ""
            }
        ],
        "venue": "Journal of neurophysiology",
        "year": 2004
    },
    "klR52hej": {
        "id": "klR52hej",
        "title": "Vascular oxidative stress increases dendritic cell adhesion and transmigration induced by homocysteine.",
        "abstract": "Atherosclerosis is a long-term chronic inflammatory and immunological disease. Endothelial dysfunction and the dendritic cell (DC) immune response are pivotal early events in atherogenesis. This study investigated the effects and possible mechanisms of action of homocysteine (Hcy) on DC adhesion to and transmigration between endothelial cells (ECs), and indicated a novel immunoregulatory mechanism by which Hcy induces atherogenesis. When ECs were stimulated with increasing concentrations of Hcy, immunofluorescence showed that endothelial reactive oxygen species (ROS) generation strikingly increased, while nitrite assay showed that nitric oxide (NO) release markedly decreased. Furthermore, DC adhesion and transmigration were significantly increased when ECs were activated by Hcy. However, pretreatment of ECs with antioxidant before Hcy markedly attenuated the induction of DC adhesion and transmigration, dependent on the intracellular ROS decrease and endothelial NO increase. In conclusion, DC adhesion and transmigration are significantly increased by vascular oxidative stress under conditions of elevated Hcy levels. These findings provide insight into the inflammatory processes and immune responses occurring in atherosclerosis induced by Hcy.",
        "keywords": [
            "atherosclerosis",
            "endothelial cells",
            "adhesion",
            "dendritic cells",
            "homocysteine",
            "nitric oxide",
            "migration",
            "reactive oxygen species",
            "endothelial cell",
            "immune response"
        ],
        "authors": [
            {
                "name": "Wei-Guo Zhu",
                "org": "Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, China"
            },
            {
                "name": "Shan Li",
                "org": "Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, China"
            },
            {
                "name": "Le-Qing Lin",
                "org": "Intensive Care Unit, The Second People\u2019s Hospital of Hangzhou, Hangzhou 310015, China"
            },
            {
                "name": "Hui Yan",
                "org": "Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, China"
            },
            {
                "name": "Ting Fu",
                "org": "Department of Gynaecology and Obstetrics, People\u2019s Hospital of Yiwu, Yiwu 322000, China"
            },
            {
                "name": "Jian-Hua Zhu",
                "org": ""
            }
        ],
        "venue": "Cellular immunology",
        "year": 2009
    },
    "OVg99H3e": {
        "id": "OVg99H3e",
        "title": "Homocysteine at pathophysiological concentrations enhances binding of dendritic cells to endothelial cells mediated by DC-SIGN.",
        "abstract": "Elevated plasma homocysteine (Hcy) is an independent risk factor for atherosclerosis, which is recognized as inflammatory and immune responses. The purpose of this study was to investigate the effect of Hcy on the interaction between dendritic cells (DCs) and endothelial cells (ECs) by upregulating the expression of DC-specific ICAM-3-grabbing nonintegrin (DC-SIGN) in cultured DCs. The immunophenotype of Hcy-treated DCs was monitored by flow cytometry. Then, they were coincubated with cultured human umbilical vein endothelial cells, and adhesion of DCs to ECs, and migration of DCs through an endothelial monolayer growing on the insert of a transwell plate, were assessed using a confocal microscope and a multi-detection microplate reader. The expression of DC-SIGN on Hcy-stimulated DCs was assessed by Western blot and immunofluorescence staining. The presence of Hcy did not change the phenotype of immature and mature DCs. Hcy promoted adhesion of DCs to ECs and migration in a concentration-dependent fashion. This effect was inhibited by an anti-DC-SIGN monoclonal antibody. The expression of DC-SIGN on DCs was significantly upregulated by Hcy in a concentration-dependent manner. Taken together, our results show for the first time that Hcy can potentiate the adhesion of DCs to ECs and migration by upregulating the expression of DC-SIGN on DCs, suggesting a novel role of Hcy in the pathogenesis of human vascular disease.",
        "keywords": [
            "dc-specific icam-3-grabbing nonintegrin",
            "adhesion",
            "dendritic cells",
            "homocysteine",
            "migration"
        ],
        "authors": [
            {
                "name": "Shan Li",
                "org": "Department of Cardiology, the First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310003, People's Republic of China"
            },
            {
                "name": "Wei-guo Zhu",
                "org": "Department of Cardiology, the First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310003, People's Republic of China"
            },
            {
                "name": "Hui Yan",
                "org": "Department of Cardiology, the First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310003, People's Republic of China"
            },
            {
                "name": "Fang-yan Fan",
                "org": "Department of Cardiology, the First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310003, People's Republic of China"
            },
            {
                "name": "Pei-yu Sun",
                "org": "Department of Cardiology, the First Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310003, People's Republic of China"
            },
            {
                "name": "Jian-hua Zhu",
                "org": ""
            }
        ],
        "venue": "International immunopharmacology",
        "year": 2007
    },
    "yJTkyRZM": {
        "id": "yJTkyRZM",
        "title": "Expression of renin-angiotensin system on dendritic cells of patients with coronary artery disease.",
        "abstract": "Dendritic cells (DCs) and renin-angiotensin system (RAS) have both been reported to contribute to the pathogenesis of atherosclerosis. Recently researches find the RAS expression on DCs and its effect on DCs' differentiation and proinflammatory function. The pattern of RAS expression on DCs derived from normal monocytes vs that on DCs derived from cornoary artery diease was investigated. In 82 coronary artery disease (CAD) patients and healthy controls (CTL), expressions of angiotensin I-converting enzyme (ACE), angiotensin AT1 receptor and DC-specific ICAM-3-grabbing nonintegrin (DC-SIGN) on DCs were measured by western-blot: CAD patients had an increased expression of ACE, AT1 receptor and DC-SIGN compared to controls especially in acute myocardial infarction (AMI). Cardiovascular risk factors of cardiovascular disease and circulating anigotensin II (Ang II) were assessed and found increased in AMI compared with CTL. The DC-SIGN and high-sensitivity C-reactive protein (hsCRP) also had significant correlations with RAS expression on DCs. Our research demonstrated the RAS expressions on DCs and their increase in CAD especially AMI. The RAS activation on DCs may cause a series of changes such as enhancing recruitment of DCs, activating the T cells and increasing their proinflammtory functions. The recruitment and T cells contact ability of DCs increases through DC-SIGN may be one of pathogenesis of atherosclerosis and this function may promoted by tissue RAS. CRP may also have some effect to the local RAS exprssion on DCs.",
        "keywords": [
            "dendritic cells",
            "coronary artery disease",
            "hscrp",
            "angiotensin ii",
            "renin-angiotensin system",
            "renin angiotensin system",
            "acute myocardial infarction"
        ],
        "authors": [
            {
                "name": "Peiyu Sun",
                "org": "the First Affiliated Hospital of Zhejiang University Department of Cardiology, School of Medicine No 79, Qin chun Road Hangzhou 310003 Zhejiang Province China"
            },
            {
                "name": "Wei Zhang",
                "org": "the First Affiliated Hospital of Zhejiang University Department of Cardiology, School of Medicine No 79, Qin chun Road Hangzhou 310003 Zhejiang Province China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "the First Affiliated Hospital of Zhejiang University Department of Cardiology, School of Medicine No 79, Qin chun Road Hangzhou 310003 Zhejiang Province China"
            },
            {
                "name": "Hui Yan",
                "org": "the First Affiliated Hospital of Zhejiang University Department of Cardiology, School of Medicine No 79, Qin chun Road Hangzhou 310003 Zhejiang Province China"
            },
            {
                "name": "Jianhua Zhu",
                "org": "the First Affiliated Hospital of Zhejiang University Department of Cardiology, School of Medicine No 79, Qin chun Road Hangzhou 310003 Zhejiang Province China"
            }
        ],
        "venue": "Inflammation",
        "year": 2009
    },
    "c41UmBTC": {
        "id": "c41UmBTC",
        "title": "MicroRNA-146a regulates the maturation process and pro-inflammatory cytokine secretion by targeting CD40L in oxLDL-stimulated dendritic cells.",
        "abstract": "There is increasing evidence that microRNAs (miRNAs) play important roles in cell proliferation, apoptosis and differentiation that accompany inflammatory responses. However, whether miRNAs are associated with dendritic cell (DC) immuno-inflammatory responses to oxidized low density lipoprotein (oxLDL) stimulation is yet unknown. Our study aims to explore the link of miRNA to lipid-overload and the immuno-inflammatory mechanism for atherosclerosis. Human primary monocyte-derived DCs were transfected with miR-146a mimics and inhibitor, and then stimulated by oxLDL. For the flow cytometric analysis of the DC immunophenotype, supernatants were collected to determine inflammatory chemokine markers. Our study clearly revealed that miRNA-146a regulates the maturation process and pro-inflammatory cytokine secretion in DCs by targeting CD40L in ox-LDL-stimulated DCs.",
        "keywords": [
            "untranslated regions",
            "oxidized low density lipoprotein",
            "oxldl",
            "dc",
            "microrna",
            "mirna",
            "microrna-146a",
            "dendritic cell",
            "il",
            "cd40l",
            "tumor necrosis factor-\u03b1",
            "tnf-\u03b1",
            "interleukin",
            "utr",
            "immuno-inflammation",
            "cell proliferation"
        ],
        "authors": [
            {
                "name": "Ting Chen",
                "org": "Department of Cardiology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China"
            },
            {
                "name": "Zhoubin Li",
                "org": "Department of Cardiothoracic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China"
            },
            {
                "name": "Tu Jing",
                "org": "Department of Cardiothoracic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Cardiology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China"
            },
            {
                "name": "Junhua Ge",
                "org": "Department of Cardiology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China"
            },
            {
                "name": "Xiaoye Zheng",
                "org": "Department of Cardiology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China"
            },
            {
                "name": "Xiaoping Pan",
                "org": "Department of Infectious Disease, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China"
            },
            {
                "name": "Hui Yan",
                "org": ""
            },
            {
                "name": "Jianhua Zhu",
                "org": ""
            }
        ],
        "venue": "FEBS letters",
        "year": 2011
    },
    "uuaun7w1": {
        "id": "uuaun7w1",
        "title": "Heme oxygenase 1 regulates the maturation process and inflammatory response in oxLDL-stimulated dendritic cells.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Hui Yan",
                "org": "Department of Cardiology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China"
            },
            {
                "name": "Ting Chen",
                "org": "Department of Cardiology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China"
            },
            {
                "name": "Zhoubin Li",
                "org": "Department of Cardiothoracic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China"
            },
            {
                "name": "Tujing",
                "org": "Department of Cardiothoracic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Cardiology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China"
            },
            {
                "name": "Junhua Ge",
                "org": "Department of Cardiology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China"
            },
            {
                "name": "Xiaoye Zheng",
                "org": "Department of Cardiology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China"
            },
            {
                "name": "Xiaoping Pan",
                "org": "Department of Infectious Disease, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China"
            },
            {
                "name": "Jianhua Zhu",
                "org": ""
            }
        ],
        "venue": "International journal of cardiology",
        "year": 2011
    },
    "hZywDH0p": {
        "id": "hZywDH0p",
        "title": "MicroRNA-29a regulates pro-inflammatory cytokine secretion and scavenger receptor expression by targeting LPL in oxLDL-stimulated dendritic cells.",
        "abstract": "There is increasing evidence that microRNAs (miRNAs) play important roles in cell proliferation, apoptosis and differentiation that accompany inflammatory responses. However, whether microRNAs are associated with DC immuno-inflammatory responses with oxidized low density lipoprotein (oxLDL) stimulation is not yet known. Our study aims to explore the link of miRNAs with lipid-overload and immuno-inflammatory mechanism for atherosclerosis. In DCs transfected with microRNA-29a mimics or inhibitors, we showed that microRNA-29a plays an important role in proinflammatory cytokine secretion and scavenger receptor expression upon oxLDL-treatment. Furthermore, we suggest an additional explanation for the mechanism of microRNA-29a regulation of its functional target, lipoprotein lipase. We conclude that microRNA-29a could regulate pro-inflammatory cytokine secretion and scavenger receptor expression by targeting lipoprotein lipase in oxLDL-stimulated dendritic cells.",
        "keywords": [
            "untranslated regions",
            "oxidized low density lipoprotein",
            "oxldl",
            "lpl",
            "lox-1",
            "sra",
            "dc",
            "microrna",
            "mirna",
            "scavenger receptor a",
            "lectin-like oxidized low-density lipoprotein receptor-1",
            "dendritic cell",
            "lipoprotein lipase",
            "microrna-29a",
            "dendritc cell",
            "il",
            "tumor necrosis factor-\u03b1",
            "tnf-\u03b1",
            "interleukin",
            "utr",
            "immuno-inflammation",
            "proinflammatory cytokine",
            "scavenger receptor",
            "cell proliferation"
        ],
        "authors": [
            {
                "name": "Ting Chen",
                "org": "Department of Cardiology, First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, PR China"
            },
            {
                "name": "Zhoubin Li",
                "org": "Department of Cardiothoracic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, PR China"
            },
            {
                "name": "Jing Tu",
                "org": "Department of Cardiothoracic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, PR China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Cardiology, First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, PR China"
            },
            {
                "name": "Junhua Ge",
                "org": "Department of Cardiology, First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, PR China"
            },
            {
                "name": "Xiaoye Zheng",
                "org": "Department of Cardiology, First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, PR China"
            },
            {
                "name": "Lin Yang",
                "org": "Department of Cardiology, First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, PR China"
            },
            {
                "name": "Xiaoping Pan",
                "org": "Department of Infectious Disease, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China"
            },
            {
                "name": "Hui Yan",
                "org": ""
            },
            {
                "name": "Jianhua Zhu",
                "org": ""
            }
        ],
        "venue": "FEBS letters",
        "year": 2011
    },
    "mrZM5MDT": {
        "id": "mrZM5MDT",
        "title": "Impairment of monocyte-derived dendritic cells in idiopathic pulmonary arterial hypertension.",
        "abstract": "With the development of immunology, the role of immune inflammation in idiopathic pulmonary arterial hypertension (IPAH) has attracted interest. Recently, it was discovered that dendritic cells, which are key players in immune inflammation, are implicated in the pathogenesis of IPAH. To elucidate the role of dendritic cells in human IPAH, we compared the changes in the number and immunological function of monocyte-derived dendritic cells (MoDCs) from the peripheral blood of patients with IPAH and healthy controls.The numbers of MoDC subsets (including plasmacytoid dendritic cells (pDCs) and myeloid dendritic cells (mDCs)) in circulating peripheral blood mononuclear cells (PBMCs) was analyzed by flow cytometry, and the concentrations of interleukin (IL)-12, IL-10, and tumor necrosis factor-alpha were measured by enzyme-linked immunosorbent serologic assay kits. The morphology, phenotypic expression, and the ability to stimulate T cell proliferation of MoDCs, cultured from PBMCs in vitro with granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-4, was analyzed by microscopy, flow cytometry, and MTT assay.The results of the study are as follows: (1) The number of circulating mDCs was lower in IPAH patients than in controls (0.07 +/- 0.01% to 0.14 +/- 0.02%; p < 0.05). (2) IL-12 levels were higher in IPAH patients than in controls (p < 0.05). (3) MoDCs showed higher expression of CD1a (53.34 +/- 7.43% to 19.29 +/- 7.37%; p < 0.05), and lower expression of costimulatory molecule CD86 (64.54 +/- 5.93% to 87.04 +/- 4.82%; p < 0.05), and less ability to simulate T cell proliferation (when the ratio is 1:10) compared to the controls.The study shows that it is possible to obtain typical DCs by culturing PBMCs from patients with IPAH with GM-CSF and IL-4, and it demonstrates that patients with IPAH have a significant change in the number of mDC and a marked immune deficiency of MoDCs.",
        "keywords": [
            "llc 2009 keywords monocyte-derived dendriticcellsmodcs. idiopathic pulmonary arterialhypertension ipah. pathology",
            "# springer science + business media",
            "tumor necrosis factor alpha",
            "flow cytometry",
            "cell proliferation",
            "peripheral blood mononuclear cell"
        ],
        "authors": [
            {
                "name": "Weiyan Wang",
                "org": "The First Affiliated Hospital of Zhejiang University, School of Medicine Department of Cardiology Hangzhou 310003 People\u2019s Republic of China"
            },
            {
                "name": "Hui Yan",
                "org": "The First Affiliated Hospital of Zhejiang University, School of Medicine Department of Cardiology Hangzhou 310003 People\u2019s Republic of China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "The First Affiliated Hospital of Zhejiang University, School of Medicine Department of Cardiology Hangzhou 310003 People\u2019s Republic of China"
            },
            {
                "name": "Yu Cui",
                "org": "The First Affiliated Hospital of Zhejiang University, School of Medicine Department of Cardiology Hangzhou 310003 People\u2019s Republic of China"
            },
            {
                "name": "Junzhu Chen",
                "org": "The First Affiliated Hospital of Zhejiang University, School of Medicine Department of Cardiology Hangzhou 310003 People\u2019s Republic of China"
            },
            {
                "name": "Xingxiang Wang",
                "org": "The First Affiliated Hospital of Zhejiang University, School of Medicine Department of Cardiology Hangzhou 310003 People\u2019s Republic of China"
            },
            {
                "name": "Shan Li",
                "org": "The First Affiliated Hospital of Zhejiang University, School of Medicine Department of Cardiology Hangzhou 310003 People\u2019s Republic of China"
            },
            {
                "name": "Jianhua Zhu",
                "org": "The First Affiliated Hospital of Zhejiang University, School of Medicine Department of Cardiology Hangzhou 310003 People\u2019s Republic of China"
            }
        ],
        "venue": "Journal of clinical immunology",
        "year": 2009
    },
    "iI4InQRC": {
        "id": "iI4InQRC",
        "title": "Angiotensin-(1-7) enhances angiotensin II induced phosphorylation of ERK1/2 in mouse bone marrow-derived dendritic cells.",
        "abstract": "It is well known that angiotensin-(1-7) (Ang-(1-7)) counterbalances vasoconstrictive and proliferative functions of angiotensin II (Ang II), some of those actions are via inhibition of Ang II induced activation of mitogen-activated protein kinases(MAPK). This study investigated the effects of Ang-(1-7) on Ang II-mediated cell signaling pathways in mouse bone marrow-derived dendritic cells (DC). The expression of receptor Mas and angiotensin-converting enzyme-related carboxypeptidase (ACE2) mRNA was examined by reverse transcription-polymerase chain reaction (RT-PCR); activation of MAPK was detected by immunoblotting after incubation of dendritic cells with Ang II in the presence or absence of Ang-(1-7), valsartan, PD123319, and D-Ala(7)-Ang-(1-7). Ang II rapidly (5 min, 10(-7) mol/L) stimulated phosphorylation of extracellular signal-related kinase (ERK1/2); this effect was partially inhibited by Ang II type 1 (AT1) receptor antagonist valsartan and significantly attenuated by Ang II type 2 (AT2) receptor antagonist PD123319. Ang-(1-7) alone also induced phosphorylation of ERK1/2; co-treatment of Ang-(1-7) and Ang II markedly enhanced ERK1/2 phosphorylation, the enhancement was eliminated by the Ang-(1-7) receptor antagonist D-Ala(7)-Ang-(1-7). Both Ang-(1-7) and Ang II had no effect on p38 and c-Jun N-terminal kinase (JNK) phosphorylation. In conclusion, Ang II stimulates ERK1/2 phosphorylation via AT2 receptor in mouse DC, Ang-(1-7) enhances this effect. Generation of Ang-(1-7) by DC could thereby counteract on the pro-inflammatory function of locally generated Ang II.",
        "keywords": [
            "receptor",
            "angiotensin-(1-7)",
            "phosphorylation",
            "angiotensin ii",
            "extracellular signal-related kinase",
            "angiotensin ii receptors",
            "mitogen activated protein kinase",
            "cell signaling",
            "reverse transcription polymerase chain reaction",
            "angiotensin converting enzyme"
        ],
        "authors": [
            {
                "name": "Wencheng Nie",
                "org": "Department of Cardiology, The First Affiliated Hospital of Zhejiang University, School of Medicine, No. 79 Qingchun Road, Hangzhou, Zhejiang 310003, PR China"
            },
            {
                "name": "Hui Yan",
                "org": "Department of Cardiology, The First Affiliated Hospital of Zhejiang University, School of Medicine, No. 79 Qingchun Road, Hangzhou, Zhejiang 310003, PR China"
            },
            {
                "name": "Shan Li",
                "org": "Department of Cardiology, The First Affiliated Hospital of Zhejiang University, School of Medicine, No. 79 Qingchun Road, Hangzhou, Zhejiang 310003, PR China"
            },
            {
                "name": "Yun Zhang",
                "org": "Department of Cardiology, The First Affiliated Hospital of Zhejiang University, School of Medicine, No. 79 Qingchun Road, Hangzhou, Zhejiang 310003, PR China"
            },
            {
                "name": "Fulin Yu",
                "org": "Department of Cardiology, The First Affiliated Hospital of Zhejiang University, School of Medicine, No. 79 Qingchun Road, Hangzhou, Zhejiang 310003, PR China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Cardiology, The First Affiliated Hospital of Zhejiang University, School of Medicine, No. 79 Qingchun Road, Hangzhou, Zhejiang 310003, PR China"
            },
            {
                "name": "Fangyan Fan",
                "org": "Department of Cardiology, The First Affiliated Hospital of Zhejiang University, School of Medicine, No. 79 Qingchun Road, Hangzhou, Zhejiang 310003, PR China"
            },
            {
                "name": "Jianhua Zhu",
                "org": ""
            }
        ],
        "venue": "Molecular immunology",
        "year": 2009
    },
    "ChbjAFB8": {
        "id": "ChbjAFB8",
        "title": "MicroRNA-155 regulates lipid uptake, adhesion/chemokine marker secretion and SCG2 expression in oxLDL-stimulated dendritic cells/macrophages.",
        "abstract": "null",
        "keywords": [
            "atherosclerosis",
            "macrophage",
            "dendritic cell",
            "microrna-155",
            "oxidized ldl"
        ],
        "authors": [
            {
                "name": "Ting Chen",
                "org": "Department of Cardiology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China"
            },
            {
                "name": "Hui Yan",
                "org": ""
            },
            {
                "name": "Zhoubin Li",
                "org": "Department of Cardiothoracic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China"
            },
            {
                "name": "Tu Jing",
                "org": "Department of Cardiothoracic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Cardiology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China"
            },
            {
                "name": "Junhua Ge",
                "org": "Department of Cardiology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China"
            },
            {
                "name": "Xiaoye Zheng",
                "org": "Department of Cardiology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China"
            },
            {
                "name": "Xiaoping Pan",
                "org": "Department of Infectious Disease, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China"
            },
            {
                "name": "Hui Yan",
                "org": ""
            },
            {
                "name": "Jianhua Zhu",
                "org": ""
            }
        ],
        "venue": "International journal of cardiology",
        "year": 2011
    },
    "2eAS39Lb": {
        "id": "2eAS39Lb",
        "title": "Ox-LDL can enhance the interaction of mice natural killer cells and dendritic cells via the CD48-2B4 pathway.",
        "abstract": "The importance of the interaction between natural killer (NK) cells and dendritic cells (DCs) in the expansion of antiviral and antitumor immune responses is well documented; however, limited information on NK/DC interaction during atherosclerosis is available. Inflammation plays an important role in the development of atherosclerosis, and oxidized low-density lipoprotein (ox-LDL) is believed to play a critical role in the development and progression of atherosclerosis. In this study, we developed a NK/DC coculture system to examine the role of ox-LDL in modulating the interaction of mice NK cells and DCs. Fresh NK cells were cocultured with DCs in the absence or presence of ox-LDL. We examined the cytokines released during the interaction. This report provides the first evidence of an enhancement effect by ox-LDL on the NK/DC crosstalk. Notably, we found that ox-LDL significantly promoted the interaction of NK cells and DCs via CD48-2B4 contact-dependent mechanisms. These findings highlight the importance of NK/DCs crosstalk in atherosclerosis and provide new information about the possible mechanisms of atherosclerosis.",
        "keywords": [
            "natural killer cell dendritic cell oxidized low-density lipoprotein atherosclerosis cd48-2b4"
        ],
        "authors": [
            {
                "name": "Kan Dong",
                "org": "Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79, Qingchun Road, Hangzhou, 310003 Zhejiang China"
            },
            {
                "name": "Jun-Hua Ge",
                "org": "Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79, Qingchun Road, Hangzhou, 310003 Zhejiang China"
            },
            {
                "name": "Shu-Lian Gu",
                "org": "Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79, Qingchun Road, Hangzhou, 310003 Zhejiang China"
            },
            {
                "name": "Shan Li",
                "org": "Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79, Qingchun Road, Hangzhou, 310003 Zhejiang China"
            },
            {
                "name": "Wei-Guo Zhu",
                "org": "Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79, Qingchun Road, Hangzhou, 310003 Zhejiang China"
            },
            {
                "name": "Fang-Yan Fan",
                "org": "Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79, Qingchun Road, Hangzhou, 310003 Zhejiang China"
            },
            {
                "name": "Jian-Hua Zhu",
                "org": "Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79, Qingchun Road, Hangzhou, 310003 Zhejiang China"
            }
        ],
        "venue": "Heart and vessels",
        "year": 2011
    },
    "Dh64aIHJ": {
        "id": "Dh64aIHJ",
        "title": "Distinct MAPK pathways are involved in IL-23 production in dendritic cells cocultured with NK cells in the absence or presence of angiotensin II.",
        "abstract": "Accumulated evidence suggests that the crosstalk between dendritic cells (DCs) and natural killer (NK) cells enhances each other's capacity, and results in the production of a variety of soluble factors. However, little is known about the effect of DC-NK crosstalk in interleukin-23 (IL-23) production. In the present study we show that DC-NK coculture caused a high expression of IL-23, angiotensin II (Ang II) alone moderately increased IL-23 production in DCs, but decreased IL-23 secretion in the DC-NK coculture system. We found that Ang II does not influence DC maturation in DC-NK crosstalk. We next investigated the mitogen-activated protein kinase (MAPK) pathway in DCs. We found that Ang II increased IL-23 production through the extracellular signal-related kinase (ERK) pathway. All three MAPK members c-Jun N-terminal kinase (JNK), ERK and p38 were involved in IL-23 production in the DC-NK coculture system. In the presence of Ang II, only the JNK pathway seems to play a role in IL-23 production in DCs cocultured with NK. These data suggest that distinct MAPK pathways are involved in IL-23 production in DCs in response to different stimuli. This work demonstrates for the first time that IL-23 is produced in the DC-NK coculture system, and that Ang II is involved in DC-NK crosstalk. This data will act as a resource that allows further exploitation of role of immune response in atherosclerosis.",
        "keywords": [
            "atherosclerosis",
            "dendritic cells",
            "interleukin-23",
            "natural killer cells",
            "mitogen-activated protein kinase",
            "angiotensin ii"
        ],
        "authors": [
            {
                "name": "Lin Yang",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Changqing Du",
                "org": "Zhejiang Hospital(Zhejiang Hospital),Hangzhou,China"
            },
            {
                "name": "Ting Chen",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Shan Li",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Wencheng Nie",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Fangyan Fan",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Jianhua Zhu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Hui Yan",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Molecular immunology",
        "year": 2012
    },
    "ho5Keiq6": {
        "id": "ho5Keiq6",
        "title": "Pioglitazone inhibits dendritic cell adhesion and transmigration through down-regulation of dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin]",
        "abstract": "To investigate the effect of pioglitazone (Pio) on dendritic cell-(DC) specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN) expression in DCs and explore the possible mechanism of Pio inhibiting DC adhesion and transmigration.DCs derived from human peripheral blood mononuclear cells were cultured and divided into 6 groups: blank control group, Pio 0.1 micromol/L group, Pio 1.0 micromol/L group, Pio 10 micromol/L group, GW9662, a peroxisome proliferator activated receptor (PPAR)-gamma antagonist, 10 micromol/L group, and GW9662 10 micromol/L + Pio 10 micromol/L group. Western blotting was used to detect the protein expression of DC-SIGN 24 h later. Human umbilical vein endothelial cells (HUVECs) were obtained and co-cultured with the DCs undergoing different treatments. Immunofluorescence test was used to detect the protein expression of DC-SIGN. DCs labeled with 5-chloromethylfluorescein diacetate (CMFDA) were added into the monocellular layer of fused ECs. Blank DCs and DCs pretreated with anti-DC-SIGN antibody were used as blank and experimental groups. Laser confocal microscopy was used to observe the adhesion ability of the DCs. HUVECs were inoculated into the upper chamber of Transwell plate and CMFDA-labeled DCs of above mentioned groups were added to the mono-cellular layer of these ECs. Serum-free culture medium with monocyte chemoattractant protein-1 was added into the lower chamber. Eight hours later the transmigration ability was observed.Western blotting showed that the DC-SIGN protein expression levels of the DCs of the Pio 1.0 micromol/L and Pio 10 micromol/L group were 0.96 +/- 0.09 and 0.80 +/- 0.08 respectively, both significantly lower than that of the blank control group (1.25 +/- 0.23, P < 0.05 and P < 0.01); and the DC-SIGN protein expression level of the GW9662 10 micromol/L + Pio 10 micromol/L group was 1.10 +/- 0.12, significantly higher than that of the Pio 10 micromol/L group (P < 0.05). Immunofluorescence test showed that the DC-SIGN protein expression levels of the DCs of the Pio 1.0 micromol/L and Pio 10 micromol/L group were 22.3 +/- 5.4 and 14.4 +/- 2.3 respectively, both significantly lower than that of the control group (29.5 +/- 5.1, P < 0.05 and P < 0.01), and the DC-SIGN protein expression level of the GW9662 10 micromol/L + Pio 10 micromol/L group was 24.9 +/- 4.3, significantly higher than that of the Pio 10 micromol/L group (P < 0.01), and not significantly different from that of the blank control group (P > 0.05). The adhesion rates of the Pio 1.0 micromol/L and Pio 10 micromol/L groups were 10.8% +/- 2.0% and 7.6% +/- 1.5% respectively, both significantly lower than that of the control group (13.4% +/- 2.1%, P < 0.05 and P < 0.01); and the adhesion rate of the GW9662 + Pio 10 micromol/L group was 12.1% +/- 1.9%, significantly higher than that of the Pio 10 micromol/L group (P < 0.01), and not significantly different from that of the blank control group (P > 0.05). The transmigration inhibition rate of DCs of the Pio 0.1, 1.0, and 10 micromol/L groups were 4.1%, 12.9%, and 17.2% compared with the transmigration rate of the blank control group (P < 0.05, P < 0.05, and P < 0.01). The transmigration rate of the GW9662 + Pio 10 micromol/L group was significantly higher than that of the Pio 10 micromol/L group (P < 0.05), and not significantly different from that of the blank control group (P > 0.05). The transmigration rate of the anti-DC-SIGN intervention group was lower by 17.8% than that of the control group (P < 0.01).Pio down-regulates the DC-SIGN protein expression and inhibits DC adhesion and transmigration through the pathway of PPAR-gamma.",
        "keywords": [
            "arteriosclerosis",
            "dendritic cells",
            "endothelial cells",
            "pioglitazone"
        ],
        "authors": [
            {
                "name": "Hui Yan",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Wei-Guo Zhu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Shan Li",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Fang-Yan Fan",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Pei-Yu Sun",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Jian-Hua Zhu",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Zhonghua yi xue za zhi",
        "year": 2008
    },
    "sQNkmAML": {
        "id": "sQNkmAML",
        "title": "PPAR-\u03b3 agonist inhibits Ang II-induced activation of dendritic cells via the MAPK and NF-B pathways",
        "abstract": "The renin-angiotensin system exerts a profound regulatory effect on the functional features of dendritic cells (DCs), thus suggesting a new target of angiotensin II (Ang II) action in the immune system. This study analyzed whether peroxisome proliferator-activated receptor-gamma (PPAR-\u03b3) activation in DCs regulated Ang II-induced activation of DCs and exploited the possible molecular mechanisms, especially focused on the signaling pathways of mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-B). Ang II stimulation of human monocyte-derived DCs resulted in an intermediate state of DC maturation and function via modulating the balance of the negative or positive regulation of the signaling pathways of extracellular regulated kinase (ERK), p38 MAPK and NF-B, but not c-Jun N-terminal kinase (JNK). Moreover, pretreatment of DCs with the PPAR-\u03b3 agonist pioglitazone reverted these effects of Ang II on DCs via suppression of the MAPK and NF-B signaling pathways at least in part. Collectively, our data support the notion that PPAR-\u03b3 activation in human DCs inhibits the activation of DCs induced by Ang II, with which involves the regulation of MAPK and NF-B signaling pathways. These findings may support the important role of these mediators in the regulation of DC-mediated inflammatory and immunologic processes. \u00a9 2010 Australasian Society for Immunology Inc. All rights reserved.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Zhu Wei-guo",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Hui Yan",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Shan Li",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Yun Zhang",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Nie Wen-cheng",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Yu Fu-lin",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Fan Fang-yan",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Ge Jun-hua",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            },
            {
                "name": "Zhu Jian-hua",
                "org": "Zhejiang University(Zhejiang University),Hangzhou,China"
            }
        ],
        "venue": "Immunology and Cell Biology",
        "year": 2010
    },
    "J3u0tkpY": {
        "id": "J3u0tkpY",
        "title": "Changes in proteomics profile during maturation of marrow-derived dendritic cells treated with oxidized low-density lipoprotein.",
        "abstract": "Increasing evidence suggests that dendritic cells (DCs) and oxidized low-density lipoprotein (ox-LDL) participate in atherosclerosis. However, few data on the molecular mechanisms of this process are available. To address this question, we used iTRAQ labeling followed by LC-MS/MS analysis to identify many proteins that changed markedly during the maturation of dendritic cells stimulated with ox-LDL. Among a total of 781 identified proteins, 93 were upregulated and 100 were downregulated. The major and significant changes in upregulated proteins were that ox-LDL not only affected the levels of intracellular cathepsins G, Z, D and S, but also significantly enhanced cathepsin S secretion by the treated cells. Our results may provide clues for a more comprehensive understanding the pathogenesis of atherosclerosis.",
        "keywords": [
            "atherosclerosis",
            "dendritic cell",
            "itraq",
            "oxidized low-density lipoprotein",
            "animal proteomics"
        ],
        "authors": [
            {
                "name": "Junhua Ge",
                "org": "Zhejiang University School of Medicine(Zhejiang University School of Medicine,Zhejiang Medical University),Hangzhou,China"
            },
            {
                "name": "Hui Yan",
                "org": "Zhejiang University School of Medicine(Zhejiang University School of Medicine,Zhejiang Medical University),Hangzhou,China"
            },
            {
                "name": "Shan Li",
                "org": "Zhejiang University School of Medicine(Zhejiang University School of Medicine,Zhejiang Medical University),Hangzhou,China"
            },
            {
                "name": "Wencheng Nie",
                "org": "Zhejiang University School of Medicine(Zhejiang University School of Medicine,Zhejiang Medical University),Hangzhou,China"
            },
            {
                "name": "Kan Dong",
                "org": "Zhejiang University School of Medicine(Zhejiang University School of Medicine,Zhejiang Medical University),Hangzhou,China"
            },
            {
                "name": "Li Zhang",
                "org": "Zhejiang University School of Medicine(Zhejiang University School of Medicine,Zhejiang Medical University),Hangzhou,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Zhejiang University School of Medicine(Zhejiang University School of Medicine,Zhejiang Medical University),Hangzhou,China"
            },
            {
                "name": "Fangyan Fan",
                "org": "Zhejiang University School of Medicine(Zhejiang University School of Medicine,Zhejiang Medical University),Hangzhou,China"
            },
            {
                "name": "Jianhua Zhu",
                "org": "Zhejiang University School of Medicine(Zhejiang University School of Medicine,Zhejiang Medical University),Hangzhou,China"
            }
        ],
        "venue": "Proteomics",
        "year": 2011
    },
    "hUpecqiO": {
        "id": "hUpecqiO",
        "title": "Genome-wide association study identifies novel susceptible loci and highlights Wnt/beta-catenin pathway in the development of adolescent idiopathic scoliosis",
        "abstract": "The genetic architecture of adolescent idiopathic scoliosis (AIS) remains poorly understood. Here we present the result of a 4-stage genome-wide association study composed of 5,953 AIS patients and 8,137 controls. Overall, we identified three novel susceptible loci including rs7593846 at 2p14 near MEIS1 (Pcombined\u2009=\u20091.19 \u00d7 10-13, OR\u2009=\u20091.21, 95% CI\u2009=\u20091.10-1.32), rs7633294 at 3p14.1 near MAGI1 (Pcombined\u2009=\u20091.85 \u00d7 10-12, OR\u2009=\u20091.20, 95% CI\u2009=\u20091.09-1.32), and rs9810566 at 3q26.2 near TNIK (Pcombined\u2009=\u20091.14 \u00d7 10-11, OR\u2009=\u20091.19, 95% CI\u2009=\u20091.08-1.32). We also confirmed a recently reported region associated with AIS at 20p11.22 (Pcombined\u2009=\u20091.61 \u00d7 10-15, OR\u2009=\u20091.22, 95% CI\u2009=\u20091.12-1.34). Furthermore, we observed significantly asymmetric expression of Wnt/beta-catenin pathway in the bilateral paraspinal muscle of AIS patients, including beta-catenin, TNIK, and LBX1. This is the first study that unveils the potential role of Wnt/beta-catenin pathway in the development of AIS, and our findings may shed new light on the etiopathogenesis of AIS.",
        "keywords": "",
        "authors": [
            {
                "name": "Zezhang Zhu",
                "org": "#N#        Department of Spine Surgery, The Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, P.R. China"
            },
            {
                "name": "Zezhang Zhu",
                "org": "#N#        Department of Spine Surgery, The Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, P.R. China"
            },
            {
                "name": "Leilei Xu",
                "org": "#N#        Department of Spine Surgery, The Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, P.R. China"
            },
            {
                "name": "Leilei Xu",
                "org": "#N#        Department of Spine Surgery, The Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, P.R. China"
            },
            {
                "name": "Nelson L.S. Tang",
                "org": "#N#        Joint Scoliosis Research Center of The Chinese University of Hong Kong and Nanjing University, Nanjing 210008 & Hong Kong 999077, P.R. China"
            },
            {
                "name": "Xiaodong Qin",
                "org": "#N#        Department of Spine Surgery, The Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, P.R. China"
            },
            {
                "name": "Xiaodong Qin",
                "org": "#N#        Department of Spine Surgery, The Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, P.R. China"
            },
            {
                "name": "Zhenhua Feng",
                "org": "#N#        Department of Spine Surgery, The Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, P.R. China"
            },
            {
                "name": "Zhenhua Feng",
                "org": "#N#        Department of Spine Surgery, The Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, P.R. China"
            },
            {
                "name": "Weixiang Sun",
                "org": "#N#        Department of Spine Surgery, The Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, P.R. China"
            },
            {
                "name": "Weixiang Sun",
                "org": "#N#        Department of Spine Surgery, The Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, P.R. China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "#N#        Department of Spine Surgery, The Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, P.R. China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "#N#        Department of Spine Surgery, The Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, P.R. China"
            },
            {
                "name": "Benlong Shi",
                "org": "#N#        Department of Spine Surgery, The Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, P.R. China"
            },
            {
                "name": "Peng Liu",
                "org": "#N#        Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun 130116, P.R. China"
            },
            {
                "name": "Saihu Mao",
                "org": "#N#        Department of Spine Surgery, The Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, P.R. China"
            },
            {
                "name": "Saihu Mao",
                "org": "#N#        Department of Spine Surgery, The Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, P.R. China"
            },
            {
                "name": "Jun Qiao",
                "org": "#N#        Department of Spine Surgery, The Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, P.R. China"
            },
            {
                "name": "Zhen Liu",
                "org": "#N#        Department of Spine Surgery, The Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, P.R. China"
            },
            {
                "name": "Xu Sun",
                "org": "#N#        Department of Spine Surgery, The Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, P.R. China"
            },
            {
                "name": "Fangcai Li",
                "org": "#N#        Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310002, P.R. China"
            },
            {
                "name": "Jack C. Y. Cheng",
                "org": "#N#        Joint Scoliosis Research Center of The Chinese University of Hong Kong and Nanjing University, Nanjing 210008 & Hong Kong 999077, P.R. China"
            },
            {
                "name": "Yong Qiu",
                "org": "#N#        Department of Spine Surgery, The Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, P.R. China"
            },
            {
                "name": "Yong Qiu",
                "org": "#N#        Department of Spine Surgery, The Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, P.R. China"
            }
        ],
        "venue": "Human Molecular Genetics",
        "year": 2017
    },
    "Wx1v7wLo": {
        "id": "Wx1v7wLo",
        "title": "Does Surgical Correction of Right Thoracic Scoliosis in Syringomyelia Produce Outcomes Similar to Those in Adolescent Idiopathic Scoliosis",
        "abstract": "Background: Practice guidelines for deformity correction in patients with syringomyelia-associated scoliosis (SMS) remain ill defined. Although surgeons experienced in treating adolescent idiopathic scoliosis (AIS) are commonly called on to treat SMS, no study has directly compared the results of surgical treatment between patients with SMS and those with AIS. The present study was performed to compare the radiographic and clinical outcomes of posterior spinal fusion between patients with right-thoracic SMS and those with right-thoracic AIS.Methods: Sixty-nine adolescents with SMS were matched with patients with AIS for sex, age, and curve magnitude. Patients were evaluated before surgery, immediately after surgery, and at the latest follow-up examination for changes in curve correction, global coronal balance, and scores on the Scoliosis Research Society (SRS)-22 questionnaire.Results: The preoperative primary curve magnitude was similar between the two groups, but a trend toward less flexibility was observed in the SMS group. The amount of correction of the thoracic Cobb angles obtained surgically (68% compared with 71%) and the ratio of percent correction to flexibility (1.80 compared with 1.76) were similar in the SMS and AIS groups. At the latest evaluation, eight patients with SMS and five with AIS had lost u003e10\u00b0 of thoracic spine correction (p = 0.382). The postoperative coronal decompensation averaged 13% and 6%, respectively, in the SMS and AIS groups (p = 0.243). No intergroup differences were noted with respect to the sagittal vertical axis or proximal junctional change, with preservation of global sagittal balance in both groups during follow-up. There were no neurologic or other major complications related to surgery in either group.Conclusions: Despite the differences in preoperative status, adolescents with idiopathic right thoracic scoliosis and those with syringomyelia-associated right thoracic scoliosis had comparable clinical and radiographic outcomes of pedicle-screw-based posterior spinal fusion, without neurologic complications.Level of Evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.",
        "keywords": "",
        "authors": [
            {
                "name": "Shifu Sha",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, People\u2019s Republic of China"
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, People\u2019s Republic of China"
            },
            {
                "name": "Weixiang Sun",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, People\u2019s Republic of China"
            },
            {
                "name": "Xiao Han",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, People\u2019s Republic of China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, People\u2019s Republic of China"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, People\u2019s Republic of China"
            }
        ],
        "venue": "Journal of Bone and Joint Surgery, American Volume",
        "year": 2016
    },
    "otzLBrKC": {
        "id": "otzLBrKC",
        "title": "Curve patterns deserve attention when determining the optimal distal fusion level in correction surgery for Scheuermann's Kyphosis.",
        "abstract": "Curve patterns should be taken into attention when determining the optimal distal fusion level in correction surgery for SK. For patients with STLK, relatively shorter fusion stopping at FLV is enough to correct Scheuermann's Kyphosis with the preservation of more lumbar motility and less development of DJK. For patients with STK, we suggest extending fusion to the SSV, which could restrict more distal junctional problems than fusion to the FLV. Large global kyphosis and correction degree might be the associated factors of developing DJK in STK patients.",
        "keywords": [
            "Curve pattern",
            "Distal fusion level",
            "Distal junctional kyphosis",
            "First lordotic vertebra",
            "Sagittal stable vertebra",
            "Scheuermann's Kyphosis"
        ],
        "authors": [
            {
                "name": "Weiguo Zhu",
                "org": "Department of Orthopaedic Surgery, Capital Medical University\u00a0Xuanwu\u00a0Hospital, Beijing, China; Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, China."
            },
            {
                "name": "Xu Sun",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, China."
            },
            {
                "name": "Wei Pan",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, China; Department of Orthopaedic Surgery, the Affiliated Huai'an Hospital of Xuzhou Medical University and the Second People's Hospital of Huai'an, Huai'an, China."
            },
            {
                "name": "Huang Yan",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, China."
            },
            {
                "name": "Zhen Liu",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, China."
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, China."
            },
            {
                "name": "Zezhang Zhu",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, China. Electronic address: zhuzezhang@126.com."
            }
        ],
        "venue": "The spine journal : official journal of the North American Spine Society",
        "year": 2019
    },
    "uR3Dgjtv": {
        "id": "uR3Dgjtv",
        "title": "Minimally Invasive Scoliosis Surgery in Lenke 5 Adolescent Idiopathic Scoliosis: A Preliminary Result",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Zezhang Zhu",
                "org": ""
            },
            {
                "name": "Zhen Liu",
                "org": ""
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            },
            {
                "name": "Bangping Qian",
                "org": ""
            },
            {
                "name": "Bin Wang",
                "org": ""
            },
            {
                "name": "Xu Sun",
                "org": ""
            },
            {
                "name": "Yang Yu",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Yong Qiu",
                "org": ""
            }
        ],
        "venue": "Global Spine Journal",
        "year": 2015
    },
    "gBiSDzoO": {
        "id": "gBiSDzoO",
        "title": "Lack of association between AKAP2 and the susceptibility of adolescent idiopathic scoliosis in the Chinese population.",
        "abstract": "Our large-scale replication study of the variants in AKAP2 gene did not support its association with the susceptibility of AIS in the Chinese population. In future study, functional studies of the previously reported rare variant are warranted to clarify whether the variant can regulate the expression of AKAP2. The whole AKAP2 gene can be sequenced in larger AIS cohorts to identify potentially missing mutations.",
        "keywords": [
            "Adolescent idiopathic scoliosis",
            "AKAP2",
            "Mutation",
            "Polymorphism"
        ],
        "authors": [
            {
                "name": "Leilei Xu",
                "org": "Department of Spine Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing, 210008, China."
            },
            {
                "name": "Chao Xia",
                "org": "Department of Spine Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing, 210008, China."
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Spine Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing, 210008, China."
            },
            {
                "name": "Zhenhua Feng",
                "org": "Department of Spine Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing, 210008, China."
            },
            {
                "name": "Xiaodong Qin",
                "org": "Department of Spine Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing, 210008, China."
            },
            {
                "name": "Weixiang Sun",
                "org": "Department of Spine Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing, 210008, China."
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing, 210008, China."
            },
            {
                "name": "Zezhang Zhu",
                "org": "Department of Spine Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing, 210008, China. zhuzezhang@126.com."
            }
        ],
        "venue": "BMC musculoskeletal disorders",
        "year": 2017
    },
    "K1fSgyYm": {
        "id": "K1fSgyYm",
        "title": "Minimally invasive scoliosis surgery assisted by O-arm navigation for Lenke Type 5C adolescent idiopathic scoliosis: a comparison with standard open approach spinal instrumentation.",
        "abstract": "OBJECTIVE Recently, minimally invasive scoliosis surgery (MISS) was introduced for the correction of adult scoliosis. Multiple benefits including a good deformity correction rate and fewer complications have been demonstrated. However, few studies have reported on the use of MISS for the management of adolescent idiopathic scoliosis (AIS). The purpose of this study was to investigate the outcome of posterior MISS assisted by O-arm navigation for the correction of Lenke Type 5C AIS. METHODS The authors searched a database for all patients with AIS who had been treated with either MISS or PSF between November 2012 and January 2014. Levels of fusion, density of implants, operation time, and estimated blood loss (EBL) were recorded. Coronal and sagittal parameters were evaluated before surgery, immediately after surgery, and at the last follow-up. The accuracy of pedicle screw placement was assessed according to postoperative axial CT images in both groups. The 22-item Scoliosis Research Society questionnaire (SRS-22) results and complications were collected during follow-up. RESULTS The authors retrospectively reviewed the records of 45 patients with Lenke Type 5C AIS, 15 who underwent posterior MISS under O-arm navigation and 30 who underwent posterior spinal fusion (PSF). The 2 treatment groups were matched in terms of baseline characteristics. Comparison of radiographic parameters revealed no obvious difference between the 2 groups immediately after surgery or at the final follow-up; however, the MISS patients had significantly less EBL (p < 0.001) and longer operation times (p = 0.002). The evaluation of pain and self-image using the SRS-22 showed significantly higher scores in the MISS group (p = 0.013 and 0.046, respectively) than in the PSF group. Postoperative CT showed high accuracy in pedicle placement in both groups. No deep wound infection, pseudarthrosis, additional surgery, implant failure, or neurological complications were recorded in either group. CONCLUSIONS Minimally invasive scoliosis surgery is an effective and safe alternative to open surgery for patients with Lenke Type 5C AIS. Compared with results of the open approach, the outcomes of MISS are promising, with reduced morbidity. Before the routine use of MISS, however, long-term data are needed.",
        "keywords": [
            "AIS = adolescent idiopathic scoliosis",
            "AVR = apical vertebral rotation",
            "AVT = apical vertebral translation",
            "CB = coronal balance",
            "EBL = estimated blood loss",
            "LL = lumbar lordosis",
            "Lenke Type 5C",
            "MISS = minimally invasive scoliosis surgery",
            "O-arm navigation",
            "PSF = posterior spinal fusion",
            "SRS-22 = 22-item Scoliosis Research Society questionnaire",
            "SVA = sagittal vertical axis",
            "T = Cobb angle of thoracic curve",
            "TK = thoracic kyphosis",
            "TL/L = Cobb angle of thoracolumbar/lumbar curve",
            "adolescent idiopathic scoliosis",
            "minimally invasive scoliosis surgery",
            "spine"
        ],
        "authors": [
            {
                "name": "Weiguo Zhu",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, People's Republic of China."
            },
            {
                "name": "Weixiang Sun",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, People's Republic of China."
            },
            {
                "name": "Leilei Xu",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, People's Republic of China."
            },
            {
                "name": "Xu Sun",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, People's Republic of China."
            },
            {
                "name": "Zhen Liu",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, People's Republic of China."
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, People's Republic of China."
            },
            {
                "name": "Zezhang Zhu",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, People's Republic of China."
            }
        ],
        "venue": "Journal of neurosurgery. Pediatrics",
        "year": 2017
    },
    "kSnZDf4u": {
        "id": "kSnZDf4u",
        "title": "Posterior fossa decompression in Chiari I improves denervation of the paraspinal muscles",
        "abstract": "Objective To investigate whether posterior fossa decompression (PFD) could improve denervation of the paraspinal muscles in patients with Chiari I malformation (CMI).Background Paraspinal muscle denervation is one of the essential elements in the pathophysiology of CMI/syringomyelia-related scoliosis. Although PFD has been widely used for managing CMI, whether denervation of the paraspinal muscles may benefit from this neurosurgical procedure remains ambiguous. Bax and Bcl-2 are two regulators of apoptosis that are closely related to the innervation status of skeletal muscles, and denervation is associated with upregulated Bax and downregulated Bcl-2.Methods Thirty-seven patients who underwent PFD and subsequent deformity correction for CMI-associated scoliosis were enrolled. Biopsy specimens were obtained from bilateral erector spinae muscles during both procedures with an average interval of 6.5 months. The biopsy site was located within the spinal innervation region involved by the syrinx and near the level of upper instrumented vertebra. The expression levels of Bax and Bcl-2 as well as histological features of the muscle fibres were examined at the two time points.Results After PFD, the mRNA level of antiapoptotic Bcl-2 was elevated by 178% and 260% in the convex and concave muscles, respectively, with a coincident decrease of 69% and 73% for proapoptotic Bax at the corresponding sites (pu003c0.001). Consistent with the mRNA data, the Bcl-2 protein in the paraspinal muscles was increased by 75% on the convex and by 169% on the concave side following PFD. For Bax protein, decreases of 45% and 52% were detected in the convex and concave muscles, respectively (pu003c0.001). On average, these changes led to a 60% decrease in the Bax/Bcl-2 ratio, suggesting reduced apoptotic signalling and improved innervation of the paraspinal muscles. Histologically, the specimens demonstrated improvements in denervation-associated changes of the muscle fibres following PFD, with the number of atrophic and necrotic/degenerated fibres decreasing significantly from 6.7 and 8.5 before surgery to 3.2 (p=0.012) and 4.2 (pu003c0.001) after surgery, respectively.Conclusion In patients with CMI, treatment with PFD led to a decrease in the Bax/Bcl-2 ratio at both the mRNA and protein levels, indicating an attenuated susceptibility to apoptotic cell death. These data, coupled with the observed improvements in histopathological features of the myofibres, suggest that PFD in Chiari I ameliorates denervation of the paraspinal muscles.",
        "keywords": "",
        "authors": [
            {
                "name": "Shifu Sha",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Zhen Liu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Xu Sun",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Zhenhua Feng",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Tao Wu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Jian Jiang",
                "org": "Department of Neurosurgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Department of Spine Surgery"
            }
        ],
        "venue": "Journal of Neurology, Neurosurgery, and Psychiatry",
        "year": 2017
    },
    "W3Z4xOXY": {
        "id": "W3Z4xOXY",
        "title": "Influence of the Occipital Orientation on Cervical Sagittal Alignment: A Prospective Radiographic Study on 335 Normal Subjects.",
        "abstract": "Cervical sagittal alignment is considered to have a special role in the pathogenesis and evaluation of cervical diseases. Previous studies have demonstrated that cervical sagittal alignment is correlated with thoracolumbar and pelvic alignments. As the direct anatomical structures connect to the cervical region, however, no parameters in the occiput have been reported to be intimately related to the alignment of the cervical spine. A retrospective radiographic study of 335 individuals (182 males and 153 females) between 18 and 60 years of age was performed between January 2007 and January 2016. The occipital incidence (OI), occipital slope (OS), occipital tilt (OT), C0-C2 angle, C2-C7 angle, C0-C7 angle, T1 slope and thoracic kyphosis were measured in every individual. The mean values of the occipital parameters of the cohort were 34.6\u00b0\u2009\u00b1\u20093.1\u00b0 for OI, 23.4\u00b0\u2009\u00b1\u20097.4\u00b0 for OS, and 11.8\u00b0\u2009\u00b1\u20093.3\u00b0 for OT. OI was constant throughout three age groups. No significant differences were noted between males and females. In addition, strong correlations were found between the occipital parameters and cervical parameters. The occipital orientation was an important factor that influenced the cervical sagittal alignment.",
        "keywords": "",
        "authors": [
            {
                "name": "Weiguo Zhu",
                "org": "Department of Spine Surgery, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China."
            },
            {
                "name": "Shifu Sha",
                "org": "Department of Spine Surgery, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China."
            },
            {
                "name": "Zhen Liu",
                "org": "Department of Spine Surgery, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China."
            },
            {
                "name": "Yang Li",
                "org": "Department of Spine Surgery, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China."
            },
            {
                "name": "Leilei Xu",
                "org": "Department of Spine Surgery, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China."
            },
            {
                "name": "Wen Zhang",
                "org": "Department of Spine Surgery, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China."
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China."
            },
            {
                "name": "Zezhang Zhu",
                "org": "Department of Spine Surgery, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China. zhuzezhang@126.com."
            }
        ],
        "venue": "Scientific reports",
        "year": 2018
    },
    "ChGu1eX4": {
        "id": "ChGu1eX4",
        "title": "Genetic Variant of GPR126 Gene is Functionally Associated With Adolescent Idiopathic Scoliosis in Chinese Population.",
        "abstract": "N/A.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaodong Qin",
                "org": "Department of Spine Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China."
            },
            {
                "name": "Leilei Xu",
                "org": ""
            },
            {
                "name": "Chao Xia",
                "org": ""
            },
            {
                "name": "Weiguo Zhu",
                "org": ""
            },
            {
                "name": "Weixiang Sun",
                "org": ""
            },
            {
                "name": "Zhen Liu",
                "org": ""
            },
            {
                "name": "Yong Qiu",
                "org": ""
            },
            {
                "name": "Zezhang Zhu",
                "org": ""
            }
        ],
        "venue": "Spine",
        "year": 2017
    },
    "stQynxRJ": {
        "id": "stQynxRJ",
        "title": "Denervation of the paraspinal muscles in patients with scoliosis secondary to Chiari malformation and syringomyelia: does it improve following posterior fossa decompression?",
        "abstract": "",
        "keywords": [
            "Chiari malformation",
            " Syringomyelia",
            " Scoliosis",
            " Posterior fossa decompression",
            " Paraspinal muscle",
            " Denervation"
        ],
        "authors": [
            {
                "name": "zezhang zhu",
                "org": "nanjing university medical school"
            },
            {
                "name": "shifu sha",
                "org": "nanjing university medical school"
            },
            {
                "name": "xu sun",
                "org": "nanjing university medical school"
            },
            {
                "name": "zhen liu",
                "org": "nanjing university medical school"
            },
            {
                "name": "huang yan",
                "org": "nanjing university medical school"
            },
            {
                "name": "weiguo zhu",
                "org": "nanjing university medical school"
            },
            {
                "name": "jun jiang",
                "org": "nanjing university medical school"
            },
            {
                "name": "yong qiu",
                "org": "nanjing university medical school"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "ZZgHLErn": {
        "id": "ZZgHLErn",
        "title": "Comparison of the scoliosis curve patterns and MRI syrinx cord characteristics of idiopathic syringomyelia versus Chiari I malformation.",
        "abstract": "Although the more readily available MR imaging has brought about more incidental findings of idiopathic syringomyelia (IS), no published study has specifically addressed the clinical and imaging features of IS-associated scoliosis. Since IS and Chiari I malformation (CMI)-type syringomyelia are hypothesized to share a common underlying developmental pathomechanism, this study aimed to investigate the scoliosis curve patterns and MRI syrinx cord characteristics of patients with IS comparing with those seen in CMI.",
        "keywords": [
            "Idiopathic syringomyelia",
            " Chiari I malformation",
            " Scoliosis",
            " Imaging feature",
            " Coronal asymmetry"
        ],
        "authors": [
            {
                "name": "zezhang zhu",
                "org": "nanjing university medical school"
            },
            {
                "name": "shifu sha",
                "org": "nanjing university medical school"
            },
            {
                "name": "winnie c c chu",
                "org": "the chinese university of hong kong"
            },
            {
                "name": "huang yan",
                "org": "nanjing university medical school"
            },
            {
                "name": "dingding xie",
                "org": "nanjing university medical school"
            },
            {
                "name": "zhen liu",
                "org": "nanjing university medical school"
            },
            {
                "name": "xu sun",
                "org": "nanjing university medical school"
            },
            {
                "name": "weiguo zhu",
                "org": "nanjing university medical school"
            },
            {
                "name": "jack c y cheng",
                "org": "the chinese university of hong kong"
            },
            {
                "name": "yong qiu",
                "org": "nanjing university medical school"
            }
        ],
        "venue": "European Spine Journal",
        "year": 2015
    },
    "542jxKNU": {
        "id": "542jxKNU",
        "title": "Tapering of the cervical spinal canal in patients with distended or non-distended syringes secondary to Chiari malformation type I",
        "abstract": "Steeper tapering of the cervical spinal canal as documented in recent studies is thought to have a role in the pathophysiology of Chiari malformation-associated syringomyelia. This study aimed to determine whether taper ratio of the cervical spinal canal differs between patients with distended and nondistended syringes.Seventy-seven adolescents (10-18 years) were divided into 2 groups: 44 with distended syrinx and 33 with nondistended syrinx. On T2-weighted MR images, anteroposterior diameter of the spinal canal was measured at each cervical level, and a linear trend line was fit by least squares regression to calculate the taper ratio. Taper ratios were compared between the 2 groups and further evaluated with respect to age and sex.In the nondistended group ND, the taper ratios for C1-C7, C1-C4, and C4-C7 averaged -0.73 \u00b1 0.57, -1.61 \u00b1 0.98, and -0.04 \u00b1 0.54, respectively, all of which were significantly steeper than those observed in the distended group (P = .001, .004, and .033, respectively). Regarding the average diameters plotted by cervical level, the narrowest region of the canal was found to occur at C4 in both groups. In addition, no significant differences in taper ratio were noted between males and females, or between older (>14 years) and younger patients (\u226414 years).Taper ratios of the cervical spinal canal were found to be different between patients with distended and nondistended syringes, indicating a reciprocal interaction between the syrinx and the cervical spine anatomy.",
        "keywords": [
            "Chiari malformation",
            " syringomyelia",
            " scoliosis",
            " cervical spinal canal",
            " tapering"
        ],
        "authors": [
            {
                "name": "zezhang zhu",
                "org": "nanjing university medical school"
            },
            {
                "name": "shifu sha",
                "org": "nanjing university medical school"
            },
            {
                "name": "xu sun",
                "org": "nanjing university medical school"
            },
            {
                "name": "zhen liu",
                "org": "nanjing university medical school"
            },
            {
                "name": "huang yan",
                "org": "nanjing university medical school"
            },
            {
                "name": "weiguo zhu",
                "org": "nanjing university medical school"
            },
            {
                "name": "jun jiang",
                "org": "nanjing university medical school"
            },
            {
                "name": "yong qiu",
                "org": "nanjing university medical school"
            }
        ],
        "venue": "AJNR. American journal of neuroradiology",
        "year": 2015
    },
    "0n8UDCvF": {
        "id": "0n8UDCvF",
        "title": "An effective delivery vehicle of demineralized bone matrix incorporated with engineered collagen-binding human bone morphogenetic protein-2 to accelerate spinal fusion at low dose.",
        "abstract": "The aim of this study was to investigate the feasibility and efficacy of a new delivery matrix using demineralized bone matrix (DBM) incorporated with collagen-binding bone morphogenetic protein-2 (CBD-BMP-2) in the rat inter-transverse spinal fusion model. Sixty rats undergoing posterolateral (inter-transverse) spinal fusion were divided into 3 groups according to the fusion materials containing different components (n\u2009=\u200920 per group). Group A were implanted with DBM, Group B with combination of DBM and BMP-2 and Group C with combination of DBM and CBD-BMP-2. After surgery, the spinal fusion of all the rats was assessed by plain radiography, CT + 3D reconstruction, manual palpation and histological evaluation. Significant difference was found in terms of solid fusion rate among the three groups, with 95% in Group C, 65% in Group B and 0% in Group A (P\u2009<\u20090.001). Compared with Groups B and A, new bone formation was observed earlier and was obvious larger, trabecular bone microarchitecture assessment was better and bone mineral density was statistically larger in Group C. In addition, more newly woven bone and osteocytes were shown by histological evaluation in Group C at 4 weeks post-operation. The present study showed CBD domain could help BMP-2 to improve the efficiency of posterolateral spinal fusion. DBM scaffold activated by collagen-binding BMP-2 was a feasible and promising bone repair vehicle. The present study showed better results in terms of plain radiography, CT + 3D reconstruction, manual palpation and histological evaluation in the rat inter-transverse spinal fusion model using DBM+CBD-BMP-2, compared with DBM+BMP-2 and DBM alone, indicating DBM scaffold activated by collagen-binding BMP-2 was a feasible and promising bone repair vehicle.",
        "keywords": "",
        "authors": [
            {
                "name": "Weiguo Zhu",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China."
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China."
            },
            {
                "name": "Fei Sheng",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China."
            },
            {
                "name": "Xinxin Yuan",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China."
            },
            {
                "name": "Leilei Xu",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China."
            },
            {
                "name": "Hongda Bao",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China."
            },
            {
                "name": "Jianwu Dai",
                "org": "State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China."
            },
            {
                "name": "Zezhang Zhu",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China. zhuzezhang@126.com."
            }
        ],
        "venue": "Journal of materials science. Materials in medicine",
        "year": 2017
    },
    "LGVDkcue": {
        "id": "LGVDkcue",
        "title": "Postoperative changes in sagittal spinopelvic alignment in sitting position in adolescents with idiopathic thoracic scoliosis treated with posterior fusion: an initial analysis.",
        "abstract": "OBJECTIVE Previous studies have reported spinal straightening and pelvic retroversion when changing from erect to sitting posture in patients with adolescent idiopathic scoliosis (AIS), which were thought to be related to low-back pain after sitting for long periods. However, the sitting sagittal alignment after posterior spinal fusion has not been evaluated. This study aims to assess the influence of posterior fusion surgery upon sitting sagittal spinopelvic alignment in adolescents with idiopathic thoracic curves (thoracic AIS [T-AIS]). METHODS A total of 44 T-AIS patients (30 Lenke I and 14 Lenke II) from the authors' center were included in this study. Preoperative and postoperative long-cassette lateral radiographs of the spine and pelvis were obtained with the patients in standing and sitting positions. Thoracic kyphosis (TK), lumbar lordosis (LL), pelvic incidence (PI), sacral slope (SS), and pelvic tilt (PT) were measured on standing and sitting lateral radiographs. Patients were divided into selective thoracic fusion (STF) and nonselective thoracic fusion (NSTF) groups. RESULTS At baseline, TK, LL, and SS decreased by 27.5%, 42.1%, and 31.1%, respectively, from the standing to the sitting position, while PT increased by 193.6%. After posterior spinal fusion, increased TK, LL, and SS and corresponding decreased PT were observed compared to baseline parameters in the sitting position. Comparison of postoperative sitting and standing values for the whole cohort showed that the mean LS and SS values were significantly lower in the sitting position (decreased by 14.0% and 13.9%, respectively, compared to standing), whereas the mean PT value was significantly greater (increased by 39.0%, compared to standing). Similar changes were also observed in the STF group: postoperatively the mean LL value was 15.6% lower in sitting than in standing, while the mean SS value was 11.5% lower. However, no obvious changes of the postoperative values in sitting were found in the NSTF group. CONCLUSIONS Nonselective thoracic fusion surgery in T-AIS patients diminished spinal straightening and pelvic retroversion during sitting. Reducing distal fusion levels was of special value in not only saving more lumbar mobility, but also preserving the function of pelvic posterior rotation.",
        "keywords": [
            "AIS = adolescent idiopathic scoliosis",
            "LIV = lowest instrumented vertebra",
            "LL = lumbar lordosis",
            "NSTF = nonselective thoracic fusion",
            "PI = pelvic incidence",
            "PT = pelvic tilt",
            "SRS-22 = 22-item Scoliosis Research Society questionnaire",
            "SS = sacral slope",
            "STF = selective thoracic fusion",
            "T-AIS = thoracic AIS",
            "TK = thoracic kyphosis",
            "adolescent idiopathic thoracic scoliosis",
            "posterior spinal fusion",
            "sagittal spinopelvic alignment",
            "sitting position",
            "spine"
        ],
        "authors": [
            {
                "name": "Weiguo Zhu",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China."
            },
            {
                "name": "Zhen Liu",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China."
            },
            {
                "name": "Shifu Sha",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China."
            },
            {
                "name": "Jing Guo",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China."
            },
            {
                "name": "Hongda Bao",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China."
            },
            {
                "name": "Leilei Xu",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China."
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China."
            },
            {
                "name": "Zezhang Zhu",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China."
            }
        ],
        "venue": "Journal of neurosurgery. Pediatrics",
        "year": 2018
    },
    "PuxR88ba": {
        "id": "PuxR88ba",
        "title": "Association of vitamin D receptor ApaI gene polymorphism with osteoporosis susceptibility in postmenopausal Han Chinese women in Xinjiang.",
        "abstract": "Osteoporosis is a polygenic disorder and has been demonstrated to be associated with ~30 candidate genes, the majority of which have also been implicated in the regulation of bone mineral density (BMD). Vitamin D receptor (VDR) is the candidate gene that has been most extensively studied. Certain studies have reported that the VDR single nucleotide polymorphism ApaI is associated with the risk of osteoporosis in Caucasian and African women. However, this association has not yet been studied in postmenopausal Han Chinese women in the Xinjiang area. In the present study, ApaI polymorphisms of VDR were defined by polymerase chain reaction-restriction fragment length polymorphism, in order to analyze the distribution of ApaI polymorphisms in postmenopausal Han Chinese women from Xinjiang. BMD was measured by dual energy X-ray absorptiometry at the lumbar spine (L2-4), Ward's triangle, great trochanter and femoral shaft. A total of 336 women were included in this study. The genotype distribution of ApaI was consistent with the Hardy-Weinberg equilibrium (all P>0.05). There were no significant differences in ApaI genotype frequencies between the 90 cases in the osteoporosis group and 246 cases in the non-osteoporosis group (P=0.946). Meanwhile, it was identified that BMD values of the tested locations were negatively correlated with age (P<0.05) and positively correlated with body mass index (BMI; P<0.05). On further attribution risk analysis, BMD was identified as a risk factor [odds ratio (OR): 0.464, 95% confidence interval (CI): 0.372-0.580, P=0.001] and BMI a protective factor (OR: 1.502, 95% CI: 1.008-2.240, P=0.032) in osteoporosis. When BMD was adjusted for confounding factors including age and BMI, it was observed that the ApaI polymorphism was not associated with BMD at the sites tested (P>0.05). In conclusion, the present study identified no significant association of the common VDR polymorphism ApaI with BMD at several skeletal sites in postmenopausal Han Chinese women in the Xinjiang area. Age was negatively correlated with BMD at different sites and identified as a risk factor; while BMI was positively correlated with BMD and identified as a protective factor.",
        "keywords": [
            "ApaI",
            "body mass index",
            "bone mineral density",
            "gene polymorphism",
            "osteoporosis"
        ],
        "authors": [
            {
                "name": "Defeng Meng",
                "org": "Department of Orthopedics, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, P.R. China."
            },
            {
                "name": "Xiao Ding",
                "org": "Department of Orthopedics, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, P.R. China."
            },
            {
                "name": "Jiaojiao Lan",
                "org": "Department of Orthopedics, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, P.R. China."
            },
            {
                "name": "Fangliang Peng",
                "org": "Department of Orthopedics, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, P.R. China."
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Orthopedics, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, P.R. China."
            },
            {
                "name": "Zeyu Cheng",
                "org": "Department of Orthopedics, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, P.R. China."
            },
            {
                "name": "Haoruo Jia",
                "org": "Department of Orthopedics, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, P.R. China."
            },
            {
                "name": "Hao Xu",
                "org": "Department of Orthopedics, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, P.R. China."
            },
            {
                "name": "Chenhui Shi",
                "org": "Department of Orthopedics, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, P.R. China."
            },
            {
                "name": "Lijuan Pang",
                "org": "Department of Pathology, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, P.R. China."
            },
            {
                "name": "Wei Shan Wang",
                "org": "Department of Pathology, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, P.R. China."
            }
        ],
        "venue": "Biomedical reports",
        "year": 2018
    },
    "ojYVi1a4": {
        "id": "ojYVi1a4",
        "title": "Lack of association between AKAP2 and the susceptibility of adolescent idiopathic scoliosis in the Chinese population.",
        "abstract": "Our large-scale replication study of the variants in AKAP2 gene did not support its association with the susceptibility of AIS in the Chinese population. In future study, functional studies of the previously reported rare variant are warranted to clarify whether the variant can regulate the expression of AKAP2. The whole AKAP2 gene can be sequenced in larger AIS cohorts to identify potentially missing mutations.",
        "keywords": [
            "Adolescent idiopathic scoliosis",
            "AKAP2",
            "Mutation",
            "Polymorphism"
        ],
        "authors": [
            {
                "name": "Leilei Xu",
                "org": "Department of Spine Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing, 210008, China."
            },
            {
                "name": "Chao Xia",
                "org": "Department of Spine Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing, 210008, China."
            },
            {
                "name": "Weiguo Zhu",
                "org": "Department of Spine Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing, 210008, China."
            },
            {
                "name": "Zhenhua Feng",
                "org": "Department of Spine Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing, 210008, China."
            },
            {
                "name": "Xiaodong Qin",
                "org": "Department of Spine Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing, 210008, China."
            },
            {
                "name": "Weixiang Sun",
                "org": "Department of Spine Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing, 210008, China."
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing, 210008, China."
            },
            {
                "name": "Zezhang Zhu",
                "org": "Department of Spine Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing, 210008, China. zhuzezhang@126.com."
            }
        ],
        "venue": "BMC musculoskeletal disorders",
        "year": 2017
    },
    "UpWk9Mdg": {
        "id": "UpWk9Mdg",
        "title": "Facile synthesis of arylboronic esters by palladacycle-catalyzed bromination of 2-arylbenzoxazoles and subsequent borylation of the brominated products",
        "abstract": "An efficient and facile synthesis of arylboronic esters bearing the benzoxazole moiety has been described using a new family of palladacycle: cyclopalladated ferrocenylimines as the catalysts. This reaction includes two concessive steps: bromination of 2-arylbenzoxazoles and subsequent borylation. The bromination of para-C-H bond was an electrophilic substitution process by using NBS as the brominating reagent, and the brominated products were determined by HMBC (1H-detected heteronuclear multiple bond correlation) spectra. Particularly, the borylation step could be carried out successively only after removal of the solvent to afford the arylboronic esters in moderate to good yields. \u00a9 2011 Elsevier Ltd. All rights reserved.",
        "keywords": [
            "palladium catalysis",
            "bromination",
            "hmbc spectra",
            "borylation"
        ],
        "authors": [
            {
                "name": "yuting leng",
                "org": "Chemistry Department, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou 450052, People\u2019s Republic of China"
            },
            {
                "name": "fan yang",
                "org": "Chemistry Department, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou 450052, People\u2019s Republic of China"
            },
            {
                "name": "weiguo zhu",
                "org": "Chemistry Department, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou 450052, People\u2019s Republic of China"
            },
            {
                "name": "dapeng zou",
                "org": "Chemistry Department, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou 450052, People\u2019s Republic of China"
            },
            {
                "name": "yangjie wu",
                "org": "Chemistry Department, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou 450052, People\u2019s Republic of China"
            },
            {
                "name": "ranran cai",
                "org": "Chemistry Department, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou 450052, People\u2019s Republic of China"
            }
        ],
        "venue": "Tetrahedron",
        "year": 2011
    },
    "aQV4c9VP": {
        "id": "aQV4c9VP",
        "title": "ChemInform Abstract: Chlorination and ortho\u2010Acetoxylation of 2\u2010Arylbenzoxazoles.",
        "abstract": "",
        "keywords": [
            "halogenation"
        ],
        "authors": [
            {
                "name": "yuting leng",
                "org": "henan university"
            },
            {
                "name": "fan yang",
                "org": "henan university"
            },
            {
                "name": "weiguo zhu",
                "org": "henan university"
            },
            {
                "name": "yangjie wu",
                "org": "henan university"
            },
            {
                "name": "xiang li",
                "org": "henan university"
            }
        ],
        "venue": "Cheminform",
        "year": 2011
    },
    "7K5COhwH": {
        "id": "7K5COhwH",
        "title": "ChemInform Abstract: Facile Synthesis of Arylboronic Esters by Palladacycle\u2010Catalyzed Bromination of 2\u2010Arylbenzoxazoles and Subsequent Borylation of the Brominated Products.",
        "abstract": "",
        "keywords": [
            "halogenation"
        ],
        "authors": [
            {
                "name": "yuting leng",
                "org": "zhengzhou university"
            },
            {
                "name": "fan yang",
                "org": "zhengzhou university"
            },
            {
                "name": "weiguo zhu",
                "org": "zhengzhou university"
            },
            {
                "name": "dapeng zou",
                "org": "zhengzhou university"
            },
            {
                "name": "yangjie wu",
                "org": "zhengzhou university"
            },
            {
                "name": "ranran cai",
                "org": "zhengzhou university"
            }
        ],
        "venue": "Cheminform",
        "year": 2011
    },
    "PhPJi6x3": {
        "id": "PhPJi6x3",
        "title": "Pd-catalyzed aminocarbonylation of alkynes with amines using Co2(CO)8 as a carbonyl source",
        "abstract": "A simple and mild protocol for the synthesis of 2-ynamides by palladium-catalyzed aminocarbonylation of alkynes was developed. The reaction proceeded at room temperature in air, utilizing Co2(CO)8 as a carbonyl source. This aminocarbonylation reaction features mild reaction conditions and good tolerance of substrates especially including aryl amines and primary amines.",
        "keywords": "",
        "authors": [
            {
                "name": "Yaxi Dong",
                "org": "The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University,Zhengzhou 450052,China"
            },
            {
                "name": "Suyan Sun",
                "org": "The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University,Zhengzhou 450052,China"
            },
            {
                "name": "Fan Yang",
                "org": ""
            },
            {
                "name": "Yu Zhu",
                "org": "The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University,Zhengzhou 450052,China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University,Zhengzhou 450052,China"
            },
            {
                "name": "Huijie Qiao",
                "org": "The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University,Zhengzhou 450052,China"
            },
            {
                "name": "Yusheng Wu",
                "org": "The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University,Zhengzhou 450052,China"
            },
            {
                "name": "Yangjie Wu",
                "org": ""
            }
        ],
        "venue": "Organic chemistry frontiers",
        "year": 2016
    },
    "VvHMYiDr": {
        "id": "VvHMYiDr",
        "title": "Direct Decarboxylative Alkynylation of \u03b1,\u03b1\u2010Difluoroarylacetic Acids under Transition Metal\u2010Free Conditions",
        "abstract": "An efficient and generally applicable protocol for decarboxylative coupling of \u03b1,\u03b1-difluoroarylacetic acids with ethynylbenziodoxolone (EBX) reagents has been developed, affording \u03b1,\u03b1-difluoromethylated alkynes bearing various functional groups in moderate to excellent yields. Remarkably, this potassium persulfate (K2S2O8)-promoted reaction employs water as solvent under transition metal-free conditions, thus providing a green synthetic approach to \u03b1,\u03b1-difluoromethylated alkynes.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiang Li",
                "org": "The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry Key Laboratory of Applied Chemistry of Henan Universities Zhengzhou University, Zhengzhou 450052, People's Republic of China"
            },
            {
                "name": "Siyu Li",
                "org": "The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry Key Laboratory of Applied Chemistry of Henan Universities Zhengzhou University, Zhengzhou 450052, People's Republic of China"
            },
            {
                "name": "Suyan Sun",
                "org": "The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry Key Laboratory of Applied Chemistry of Henan Universities Zhengzhou University, Zhengzhou 450052, People's Republic of China"
            },
            {
                "name": "Fan Yang",
                "org": "The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry Key Laboratory of Applied Chemistry of Henan Universities Zhengzhou University, Zhengzhou 450052, People's Republic of China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry Key Laboratory of Applied Chemistry of Henan Universities Zhengzhou University, Zhengzhou 450052, People's Republic of China"
            },
            {
                "name": "Yu Zhu",
                "org": "The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry Key Laboratory of Applied Chemistry of Henan Universities Zhengzhou University, Zhengzhou 450052, People's Republic of China"
            },
            {
                "name": "Yusheng Wu",
                "org": "Tetranov Biopharm, LLC. 75 Daxue Road, Zhengzhou 450052, People's Republic of China"
            },
            {
                "name": "Yangjie Wu",
                "org": "The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry Key Laboratory of Applied Chemistry of Henan Universities Zhengzhou University, Zhengzhou 450052, People's Republic of China"
            }
        ],
        "venue": "Advanced Synthesis & Catalysis",
        "year": 2016
    },
    "xlQTvWl1": {
        "id": "xlQTvWl1",
        "title": "Palladium-catalyzed direct C\u2013H arylation of ferrocenecarboxamides with aryl halides",
        "abstract": "A simple and facile protocol for the palladium-catalyzed ortho-arylation of ferrocenecarboxamides with aryl halides was developed with the assistance of the bidentate directing group. The substrate scope could be extended to aryl iodides, bromides and even chlorides, as well as heterocyclic halides, affording diarylated products in moderate to good yields.",
        "keywords": "",
        "authors": [
            {
                "name": "Huijie Qiao",
                "org": "The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University,Zhengzhou 450052,People's Republic of China"
            },
            {
                "name": "Suyan Sun",
                "org": "The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University,Zhengzhou 450052,People's Republic of China"
            },
            {
                "name": "Fan Yang",
                "org": "The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University,Zhengzhou 450052,People's Republic of China"
            },
            {
                "name": "Yu Zhu",
                "org": "The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University,Zhengzhou 450052,People's Republic of China"
            },
            {
                "name": "Weiguo Zhu",
                "org": "The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University,Zhengzhou 450052,People's Republic of China"
            },
            {
                "name": "Yusheng Wu",
                "org": "Tetranov Biopharm, LLC., 75 Daxue Road,Zhengzhou,People's Republic of China"
            },
            {
                "name": "Yangjie Wu",
                "org": "The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University,Zhengzhou 450052,People's Republic of China"
            }
        ],
        "venue": "RSC Advances",
        "year": 2016
    },
    "w9h950f9": {
        "id": "w9h950f9",
        "title": "Expression profiling of peroxisome proliferation activate receptor \u03b32 and phosphorylation during adipogenic differentiation of Adipose-derived Stem Cells",
        "abstract": "Objective: To investigate PPAR\u03b32 expression and phosphorylation involved in adipogenic differentiations of Adipose-derived Stem Cells (ASCs) with an aim to reveal the possible mechanisms of adipose development. Methods: ASCs were obtained from the inguinal fat pads of GFP (green fluorescent protein) mice. The primary cells were cultured in histiocytic attachment cultivation. Adipogenic differentiation of the third generation of ASCs was induced with the conditional medium (\u03b1-MEM medium supplemented with 100 mL/L fetal bovine serum, 10 -6 mol/L dexamethasone, 10 -5 mol/L insulin, 0. 2 mmol/L indomethacin, and 0. 5 mmol/L 3 -isobutyl-l-methylxanthine). The levels of PPAR\u03b32 mRNA and the PPAR\u03b32 expression and phosphorylation at day 0, 1, 3, 5, 7, and 9 of induction were detected using RT-PCR, fluorescence-immunocytochemistry and western blot, respectively. Results: The expression of PPAR\u03b32 and phosphorylation were significantly up-regulated during adipogenic differentiation of ASCs. Conclusion PPAR\u03b32 is the key regulator of adipose development. The regulation of PPAR\u03b32 phosphorylation may promote adipogenic differentiation of ASCs.",
        "keywords": [
            "Adipogenic differentiation",
            "Adipose-derived Stem Cells",
            "Phosphorylation",
            "PPAR\u03b32"
        ],
        "authors": [
            {
                "name": "SUN Qin-ce",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "XIAO Jin-gang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "YANG Xiao-juan",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2011
    },
    "LshIWrMT": {
        "id": "LshIWrMT",
        "title": "Growth factors in vascularization of adipose tissue engineering",
        "abstract": "Tissue engineering is the construction of new tissue and organs for reparative purposes. In order to implant tissues of greater size to survive,the tissue has to be vascularized,and implementing the vascularization as early as possible is pivotal to the success of the engineered tissue. Adipose tissue engineers use two main methods to create a vascularised structure:Stimulation of the endogenous angiogenic responses by the vascular growth factors,and formation of structures that mimic the vascular tree of the organ or tissue to be replaced. We will illustrate the growth factors of vascularization utilized for obtaining optimal results in the field,and the fabricating methods of the scaffold using these vascular growth factors in vivo and in vitro.",
        "keywords": [
            "vascularization",
            "adipose tissue engineering",
            "growth factor"
        ],
        "authors": [
            {
                "name": "KONG Zi-ren",
                "org": "State Key Laboratory of Oral Diseases,Sichuan University,Chengdu ,China"
            },
            {
                "name": "YANG Xiao-juan",
                "org": "State Key Laboratory of Oral Diseases,Sichuan University,Chengdu ,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "State Key Laboratory of Oral Diseases,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "International Journal of Stomatology",
        "year": 2010
    },
    "NTjoGyx1": {
        "id": "NTjoGyx1",
        "title": "Expression of miRNA-22 during adipogenic differentiation process of adipose tissue-derived stromal cells in vitro",
        "abstract": "BACKGROUND: Adipose derived stromal cells (ADSCs) can differentiate to lipocytes under specific conditions, however, the detailed regulatory mechanisms of ADSCs adipogenic differentiation have not yet completely understood. OBJECTIVE: To definite the acts and the possible mechanism of miRNA in the adipogenic differentiation process of ADSCs. DESIGN, TIME AND SETTING: An observation controlled experiment was performed in the State Key Laboratory of Oral Diseases, Sichuan University between October 2007 and March 2008. MATERIALS: Eight male SD neonatal rats within 30 birth days were used to take out fat tissues and to obtain highly purified ADSCs with density gradient centrifugation and adherent culture methods. METHODS: The third generation of ADSCs were induced into adipogenic differentiation with the inductive medium. The in vitro model of the adipogenic differentiation of ADSCs was established, and the miRNA gene chip technology was applied to screen the correlated miRNA during the ADSCs adipogenesis. Real-time quantitative PCR was used to verify the miRNA result. MAIN OUTCOME MEASURES: Circled digit oneCellular morphology; Circled digit twoOil red O and immunocytochemical detection of PPAR\u03b3; Circled digit three miRNA-22 chip; Circled digit fourreal-time quantitative PCR. RESULTS: Circled digit oneThe adipogenic differentiation of ADSCs was confirmed by microscopy, staining with Oil red O and immunocytochemical detection of PPAR\u03b3. Circled digit twoThe miRNA-22 expression had a declining trend in the induced group discovered in the miRNA result. Circled digit threeThe result of real-time quantitative PCR showed that the miRNA-22 expression in the induction group was significantly lower than that in the control group (P < 0.05). CONCLUSION: The miRNA-22 expression have a remarkable decline in the adipogenic differentiation process of ADSCs, which indicates that miRNA-22 may be involved in the regulation process of adipogenic differentiation of ADSCs. Bioinformatics analysis shows that the adipogenic differentiation process is possibly carried out by regulating MAPK7 (ERK5), which is the target gene of miRNA-22.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Yan Feng Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Chen Jian-lin",
                "org": "Lingwu People's Hospital(Lingwu People's Hospital),,China"
            },
            {
                "name": "Xiao Jin-gang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yong Zhang",
                "org": "Jiaozuo Coal Industrial (Group) Co. Ltd.(),,China"
            },
            {
                "name": "Xiaoy\u00fc Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Tian Wei-dong",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Journal of Clinical Rehabilitative Tissue Engineering Research",
        "year": 2009
    },
    "GFiiLwsg": {
        "id": "GFiiLwsg",
        "title": "Expression of human interleukin-1 receptor antagonist in the transfected chondrocytes of temporomandibular joint]",
        "abstract": "To investigate the expression of the human interleukin-1 receptor antagonist (hIL-1ra) in the transfected chondrocytes of temporomandibular joint (TMJ).Chondrocytes of TMJ in vitro were transfected by hIL-1ra gene via cationic liposome as a medium. The stable transfected cells were selected by G418. The proliferations of the transduced cell were examined with the growth curve, cell population doubling time. The protein expressing in different periods was detected by immunocytochemistry and enzyme-linked immunosorbent assay (ELISA).The proliferation suppression of gene transfected cells fell significantly with compared to normal cells. The expression of hIL-1ra was detected in the cell plasma and the cell culture supernatant. The highest expression of IL-1ra protein was at the time of 48 hours after gene transfection. The transiently transfected cells were secreted IL-1ra protein continuously 28 days and the stably transduced cells were secreted IL-1ra protein till 72 days.This study showed that hIL-1ra protein expressed positively in the cell plasma and the culture supernatant after gene transfection within a certain periods.",
        "keywords": [
            "gene transfection",
            "cationic liposome",
            "human interleukin-1 receptor antagonist"
        ],
        "authors": [
            {
                "name": "Yi-Song Li",
                "org": "Dept.of Oral and Maxillofacial Surgery,The First Affiliated Hospital of Kunming Medical College,Kunming ,China"
            },
            {
                "name": "Wei-Dong Tian",
                "org": "Dept.of Oral and Maxillofacial Surgery,West China College of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Sheng-Wei Li",
                "org": "Dept.of Oral and Maxillofacial Surgery,West China College of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Liu Liu",
                "org": "Dept.of Oral and Maxillofacial Surgery,The First Affiliated Hospital of Kunming Medical College,Kunming ,China"
            },
            {
                "name": "Xiao-Ming Dai",
                "org": "Dept.of Oral and Maxillofacial Surgery,The First Affiliated Hospital of Kunming Medical College,Kunming ,China"
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2006
    },
    "peL1GUEN": {
        "id": "peL1GUEN",
        "title": "The research on the induction of secretome by adipose tissue for adipose-derived stem cells",
        "abstract": "Objective: Study the role for adipose tissue-derived stem cells (ADSCs) of secretome by adipose tissue and hoped that makes some contributions for the fat regeneration. Methods: Direct adherent culture methods and the flow cytometry (FCM) were used to isolate and identify ADSCs. Collected the medium that had contained secreted proteins as the conditional medium (CM) and was used to induce ADSCs, chemical medium group as the positive control and normal medium group as the negative control. The formation of lipid drops was observed through the cell morphology, and the reliability was verified through Real-time PCR of the mRNA level in vitro. To test the effect of CM on ADSCs in vivo, the absorbable gelatin sponge was used as a scaffold for ADSCs. Results: FCM ensured that the cultured cells were ADSCs. Significant increased lipid drops and related mRNA levels were observed in induced ADSCs cultured for 4 days, which indicated that the CM could promote the ADSCs differentiate into adipocytes after cultured for 4 days in vitro. The secreted proteins could promote ADSCS differentiate into vascularization tissues in vivo. Conclusion: The secreted proteome may contain some growth factors that can promote ADSCs to differentiate into adipocytes and vascularization, which may give new directions for the growth factors that could be applied in the repair of soft tissue.",
        "keywords": [
            "Adipocytes",
            "Adipose tissue-derived stem cells",
            "Secretome",
            "The absorbable gelatin sponge"
        ],
        "authors": [
            {
                "name": "Ju-Rong Liao",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jie Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Ke Huang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Feng Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Kun Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei-Hua Guo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Mei Yu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Cong Guo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei-Dong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2012
    },
    "gAWvQKk0": {
        "id": "gAWvQKk0",
        "title": "Regulating mechanism of periodontal tissue regeneration",
        "abstract": "During the past decade, many important achievements have been made in the field of periodontal tissue regeneration. The ultimate goal of periodontal tissue regeneration is the reconstitution of the lost periodontal structures. Recently, the regeneration of cementum has attracted more and more attention. The purpose of this article is to review the literature with respect to the possible regulating mechanism of periodontal tissue regeneration.",
        "keywords": [
            "regeneration",
            "regulating mechanism",
            "periodontal tissue",
            "cementum"
        ],
        "authors": [
            {
                "name": "FENG Fan",
                "org": "Dept. of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu , China"
            },
            {
                "name": "TANG Wei",
                "org": "Dept. of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu , China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "Dept. of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu , China"
            }
        ],
        "venue": "International Journal of Stomatology",
        "year": 2008
    },
    "rOG3javL": {
        "id": "rOG3javL",
        "title": "Biomechanical study of rigid internal fixation for mandibular angle fracture]",
        "abstract": "To develop a functional biomechanical mandibular model, and to observe the stress distribution of angle-fractured mandible under different rigid internal fixation (RIF) methods.A biomechanical model of mandible was built which include the simulative temporal-mandibular joint (TMJ) and was under mechanical loads of masseter, temporalis, medial pterygoid and lateral pterygoid. The different stress pattern was measured by strain gauges. Under the standard mandibular angle fracture, bilateral molar biting and four pairs of muscles loading, the strains were compared to evaluate the stability of one-or two-miniplate fixation.The fixation of miniplate in the lateral oblique line can recover the main stress on the non-fracture side, but it was broken in the fracture side. The tension increased in the lower border of mandibular angle.Through the biomechanical study based on the functional mandibular model, only one miniplate fixation in lateral oblique line for mandible angle fracture was insufficient buttressing of the segments, while the additional miniplate in the lower margin can recover the stress pattern and provide more stability.",
        "keywords": [
            "biomechanics",
            "rigid internal fixation",
            "mandibular angle fracture"
        ],
        "authors": [
            {
                "name": "Hang Wang",
                "org": " Key. Laboratory of Oral Biomedical Engineering Ministry of Education, SichuanUniversity, Chengdu , China"
            },
            {
                "name": "Meng-Shi Chen",
                "org": " Key. Laboratory of Biomedical Engineering, Architecture and Environment College, Sichuan University, Chengdu , China"
            },
            {
                "name": "Wei Tang",
                "org": " Dept. of Oral and Maxillofacial Surgery, West China Collegeof Stomatology,Sichuan University, Chengdu , China"
            },
            {
                "name": "Wei-Dong Tian",
                "org": " Dept. of Oral and Maxillofacial Surgery, West China Collegeof Stomatology,Sichuan University, Chengdu , China"
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2006
    },
    "dmo881GA": {
        "id": "dmo881GA",
        "title": "Biomechanical analysis of 12 different dental implant geometries",
        "abstract": "Biomechanical performances of 12 different dental implant systems were analyzed using finite element method and judgement of pros and cons of implants geometry was also given. The 12 analysis models which have the same length, diameter and thread were reference to the existing dental implant systems. The numerical model of the right mandibular incisor bone segment was reconstructed from CT data and the implant was inserted along toothroot direction. Distributions of stresses and deformations in the bone for 12 implants under vertical/lateral loads were obtained and ranked into statistical scores which were used to judge the optimum geometry of implants. Analytical results showed that the cylindrical implant which produce a smaller stresses and deformations in the mandibular incisor has an optimum shape among 12 studied implants.",
        "keywords": [
            "Dental implant",
            "Finite element method",
            "Sorting method with statistical score"
        ],
        "authors": [
            {
                "name": "Rui Liang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "GUO Wei-hua",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "WEN Hai-lin",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "WEI Yong-tao",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Sichuan Daxue Xuebao (Gongcheng Kexue Ban)/Journal of Sichuan University (Engineering Science Edition)",
        "year": 2012
    },
    "QDTENEAP": {
        "id": "QDTENEAP",
        "title": "Influence of fetal bovine serum protein concentration in adipose tissue extract on adipogenic differentiation of adipose derived stem cells]",
        "abstract": "To observe whether fetal bovine serum (FBS) will affect the adipogenic ability of adipose derived stem cells (ADSCs) induced by adipose tissue extract (ATE), and to explore the effects of different FBS protein concentrations in ATE on adipogenic ability, cell proliferation and migration of ADSCs.Rat ADSCs were cultured, passaged, and then subjected to osteogenic and neural induction. The adipose explants were cultured in culture medium with or without FBS, then ATE was collected to induce passage four (P4)-ADSCs, which were subsequently detected with oil red staining on the 7th day and the adipogenic ratio was calculated. Different concentrations of ATE without FBS (100 microg/mL, 250 microg/mL and 500 microg/mL) were used to induce P4-ADSCs before the adipogenic events, and the adipogenic ratio of each concentration group was observed. The effect of different protein concentrations on ADSCs proliferation and migration was also observed.Alizarin red staining and NF immunofluorescence staining were positive after the osteogenic and neural induction of cultured ADSCs. Either ATE with or without FBS was able to induce adipogenic differentiation of ADSCs on the 3rd day and there was no significant differences of adipogenic differentiation between ATE with FBS and without FBS on the 7th day. The adipogenic ratio of 500 microg/mL group was higher than that of 100 pg/mL group and 250 microg/mL group (P < 0.05). After two days of induction, all the three different protein concentrations could inhibit cell proliferation, and different protein concentrations in ATE had no effect on the migration of ADSCs.ATE obtained from culture medium without FBS has no effect on adipogenic capacity of ADSCs in a short period of time. The adipogenic ratio of ADSCs is associated with protein concentration in ATE.",
        "keywords": [
            "Adipose derived stem cells",
            "Adipose tissue extract",
            "Concentration"
        ],
        "authors": [
            {
                "name": "Ting Li",
                "org": ".1.The Affiliated Stomatology Hospital,Chongqing Medical University of Stomatology,Chongqing ,China;Chongqing Key Laboratory of Research Center for Oral Diseases and Biomedical Science,Chongqing ,China"
            },
            {
                "name": "Yong Li",
                "org": ".1.The Affiliated Stomatology Hospital,Chongqing Medical University of Stomatology,Chongqing ,China;Chongqing Key Laboratory of Research Center for Oral Diseases and Biomedical Science,Chongqing ,China"
            },
            {
                "name": "Wei-Dong Tian",
                "org": "State Key Laboratory of Oral Diseases,Sichuan University,Chengdu ,China;Engineering Center in Oral Biomechanics,Sichuan University,Chengdu ,China;Department of Oral and Maxillofacial Surgery,West China College of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Wei-Hua Guo",
                "org": "State Key Laboratory of Oral Diseases,Sichuan University,Chengdu ,China;Engineering Center in Oral Biomechanics,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Mei Yu",
                "org": "State Key Laboratory of Oral Diseases,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Xiao-Dong Li",
                "org": ".1.The Affiliated Stomatology Hospital,Chongqing Medical University of Stomatology,Chongqing ,China;Chongqing Key Laboratory of Research Center for Oral Diseases and Biomedical Science,Chongqing ,China"
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2013
    },
    "DKk1032q": {
        "id": "DKk1032q",
        "title": "The research advances of Basic fibroblast growth factor",
        "abstract": "Basic fibroblast growth factor(FGF-2) is an important modulator of cell growth and differentiation under both physiological and pathological conditions.FGF-2 is known to induce chemotactic,angiogenic,and mitogenic activity and plays an important role in early differentiation and developmental processes.Via binding its specific transmembrane receptors(fibroblast growth factor receptors,FGFRs),FGF-2 activates the subsequent intracellular second messenger cascades and leads to diverse biological effects.This paper describes the biological substructure of FGF-2,signal transduction and its biological functions.",
        "keywords": [
            "Biological functions",
            "Receptors",
            "FGF-2",
            "Signal transduction"
        ],
        "authors": [
            {
                "name": "SUN Qin-ce",
                "org": "1 College of life science,Sichuan University,Chengdu,,China "
            },
            {
                "name": "TIAN Wei-dong",
                "org": "2 West China College of Stomatology Sichuan University,Chengdu,,China"
            }
        ],
        "venue": "Progress in Modern Biomedicine",
        "year": 2009
    },
    "UK41cqp8": {
        "id": "UK41cqp8",
        "title": "Research Progress in the Natural Agonists of PPAR\u03b3",
        "abstract": "The peroxisome proliferator-activated receptor-\u03b3(PPAR\u03b3) , a ligand-activated transcription factor, belongs to the nuclear hormone receptor superfamily.It has important roles in adipogenesis and immune response as well as in both lipid and carbohydrate metabolism.Although synthetic agonists for PPAR\u03b3 are widely used as insulin sensitizers, the identity of natural agonists for PPAR\u03b3 is still unclear.At present, the natural agonists of PPAR\u03b3 mainly include oxidized and nitrated fatty acids, such as 9-hydroxyoctadecadienoic acid(9-HODE), 13-hydroxyoctadecadienoic acid(13-HODE), and 15-deoxy-\u039412, 14-prostaglandin J2, OA-NO2 and LNO2.This article reviewed the recent achievements of natural agonists of PPAR\u03b3.",
        "keywords": [
            "Ligand-binding domain",
            "Natural agonists",
            "PPAR\u03b3"
        ],
        "authors": [
            {
                "name": "LIAO Li-zi",
                "org": "State Key Laboratory of Oral Diseases, Sichuan University, Chengdu , China"
            },
            {
                "name": "LIU Lei",
                "org": "State Key Laboratory of Oral Diseases, Sichuan University, Chengdu , China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "State Key Laboratory of Oral Diseases, Sichuan University, Chengdu , China"
            }
        ],
        "venue": "Progress in Modern Biomedicine",
        "year": 2009
    },
    "mU9bVDLW": {
        "id": "mU9bVDLW",
        "title": "Mechanism and transcription factors regulating adipogenic differentiation",
        "abstract": "Adipogenic differentiation is the result of transcriptional remodelling that leads to activation of a large number of adipose-related genes. Various hormones, cytokines, signaling molecules and nutrients usually act as coregulators that either promote or block the cascade of transcription factors that co-ordinate the differentiation process. This article reviews the achievements of adipogenic differentiation regulation mechanism in recent years.",
        "keywords": [
            "mechanism",
            "transcription factors",
            "adipogenesis"
        ],
        "authors": [
            {
                "name": "YANG Xiao-juan",
                "org": "Dept. of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu , China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "Dept. of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu , China"
            }
        ],
        "venue": "International Journal of Stomatology",
        "year": 2008
    },
    "0xUrGgNt": {
        "id": "0xUrGgNt",
        "title": "Clinical study of surgical treatment for panfacial fractures",
        "abstract": "Objective To discuss the surgical treatment points for panfacial fractures and complications and explore the biological osteosynthesis principles suitable for treatment of oral and maxillofacial fractures. Methods According to biological osteosynthesis principles, 48 cases with facial deformity and occlusion disturbance resulted from panfacial fractures were treated by using such techniques including X-ray cephalometric analysis, model surgery, open reduction and rigid internal fixation. Results All cases obtained successful correction of the maxillofacial deformities. Conclusions Accurate preoperative plan, systematical and appropriate choice of surgical methods are key to good treatment outcome. At the same time, treatment of bone fractures must attach importance to biological characteristics of bone, for example, appropriate choice of plates and screw system, appropriate choice of reposition and fixation methods, the combination of rigid fixation and elasticity fixation, and reconstruction of bone defects.",
        "keywords": [
            "Surgical operation",
            "faces",
            "Clinial protocols",
            "Fractures"
        ],
        "authors": [
            {
                "name": "TANG Wei",
                "org": ". West China College of Stomatology, Sichuan University, Chengdu , China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": ". West China College of Stomatology, Sichuan University, Chengdu , China"
            },
            {
                "name": "ZHENG Xiao-hui",
                "org": ". West China College of Stomatology, Sichuan University, Chengdu , China"
            },
            {
                "name": "LIU Lei",
                "org": ". West China College of Stomatology, Sichuan University, Chengdu , China"
            },
            {
                "name": "TANG You-chao",
                "org": ". West China College of Stomatology, Sichuan University, Chengdu , China"
            },
            {
                "name": "CHEN Xi-zhe",
                "org": ". West China College of Stomatology, Sichuan University, Chengdu , China"
            },
            {
                "name": "LI Sheng-wei",
                "org": ". West China College of Stomatology, Sichuan University, Chengdu , China"
            }
        ],
        "venue": "Chinese Journal of Trauma",
        "year": 2005
    },
    "16qODU36": {
        "id": "16qODU36",
        "title": "Mirror imaging and preshaped titanium plates in the treatment of unilateral malar and zygomatic arch fractures.",
        "abstract": "The aim of this study is to discuss the application of mirror imaging and preshaped titanium plates in the treatment of unilateral malar and zygomatic arch fractures.Four patients with unilateral malar and zygomatic arch fractures were included in this study. All patients underwent preoperative CT scan. CT data were processed with Surgicase. Two 3D skull models were reconstructed using a rapid prototyping device. The first model was the original model obtained from CT scanning; the other model was obtained by mirroring the unaffected side onto the fractured side. Simulation surgery was performed on the first model. For the second model, titanium plates were shaped in advance and a resinous guide plate was created to guide surgical reduction. When using the resinous guide plates, 4 patients' fractures were reduced and fixed with preshaped titanium plates. The pre- and postoperative displacement of zygomatic markers were analyzed in Surgicase.According to the measurement of fracture displacements, the facial asymmetry of all 4 patients was greatly improved at the 1-month follow-up.Mirror imaging and preshaped titanium plates are viable choices for the treatment of unilateral malar and zygomatic arch fractures. Combined use of these techniques can improve facial symmetry.",
        "keywords": [
            "titanium"
        ],
        "authors": [
            {
                "name": "Fan Feng",
                "org": "Resident, Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Hang Wang",
                "org": "Associate Professor, Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Xiaoguang Guan",
                "org": "Resident, Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Weidong Tian",
                "org": "Professor, Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Wei Jing",
                "org": "Assistant Professor, Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Jie Long",
                "org": "Associate Professor, Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Wei Tang",
                "org": "Professor, Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Lei Liu",
                "org": ""
            }
        ],
        "venue": "Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics",
        "year": 2011
    },
    "fl5XXO9E": {
        "id": "fl5XXO9E",
        "title": "Induction of transforming growth factor-beta 1 on dentine pulp cells in different culture patterns.",
        "abstract": "Recent studies have documented that TGF-beta1 takes part in dental pulp tissue repair. Moreover, dental pulp cells have the potential to differentiate into odontoblast-like cells and produce reparative dentine in this process. However, the molecular mechanisms and potential interactions between TGF-beta1 and dental pulp cells are not clear due to the complexity of the pulp/dentine microenvironment. In this study, we investigated the induction of TGF-beta1 on the dental pulp cells in cell culture, tissue culture and three-dimensional culture patterns. These results demonstrated that TGF-beta1 significantly increased the proliferation of cells and activity of ALPase. Dental pulp cells cultured in the presence of TGF-beta1 formed mineralization nodules. In the organ culture, dental pulp cells treated with TGF-beta1 differentiated into odontoblast-like cells and formed a pulp-dentinal complex; and TGF-beta1 significantly induced synthesis of dentine relative proteins DSPP, DMP-1. The dental pulp cells share some characteristics of the odontoblast, such as a parallel arrangement with columnar form and a unilateral cell process. Together, these data indicate that TGF-beta1 can make dental pulp cells differentiated into odontoblast-like cells and form the pulp-dentinal complex. Moreover, these results suggest that TGF-beta1 is an important regulatory factor in odontoblast differentiation during tooth development and pulp repair.",
        "keywords": [
            "odontoblast",
            "dentine pulp cells",
            "three-dimensional culture",
            "tissue culture",
            "transforming growth factor",
            "cell differentiation",
            "electron microscopy",
            "cell culture",
            "organ culture",
            "polymerase chain reaction",
            "transforming growth factor beta",
            "molecular mechanics",
            "three dimensional",
            "dental pulp"
        ],
        "authors": [
            {
                "name": "Xin Nie",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yongjie Zhang",
                "org": "The Fourth Military Medical University(Fourth Military Medical University,The Fourth Military Medical University),Xi'an,China"
            },
            {
                "name": "Xizhe Chen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Rui Dong",
                "org": "The Fourth Military Medical University(Fourth Military Medical University,The Fourth Military Medical University),Xi'an,China"
            },
            {
                "name": "Ming Jiang",
                "org": "The Fourth Military Medical University(Fourth Military Medical University,The Fourth Military Medical University),Xi'an,China"
            },
            {
                "name": "Famin Chen",
                "org": "The Fourth Military Medical University(Fourth Military Medical University,The Fourth Military Medical University),Xi'an,China"
            },
            {
                "name": "Yan Jin",
                "org": "The Fourth Military Medical University(Fourth Military Medical University,The Fourth Military Medical University),Xi'an,China"
            }
        ],
        "venue": "Cell biology international",
        "year": 2006
    },
    "jADtzZgL": {
        "id": "jADtzZgL",
        "title": "Ectopic and in situ bone formation of adipose tissue-derived stromal cells in biphasic calcium phosphate nanocomposite.",
        "abstract": "Adipose-derived stromal cells (ASCs) have the potential to differentiate into a variety of cell lineages both in vitro and in vivo. A novel biodegradable biphasic calcium phosphate nanocomposite (NanoBCP) comprising beta-tricalcium phosphate matrix and hydroxyl apatite nanofibers is favorable for bone tissue engineering. In this study, ASCs were harvested from Sprague-Dawley (SD) rats and induced to osteogenesis before seeded into porous NanoBCP scaffold. To determine ectopic in vivo osteogenic differentiation, these constructs were implanted in nude mice subcutaneously. Meanwhile, the ability of engineered constructs to stimulate in situ bone repair was assessed in rat critical-size cranial defects. The defects were filled with NanoBCP containing osteogenic ASCs in experimental group; with cell-free NanoBCP in negative controls; and with nothing in blank controls. The retrieved specimens were analyzed with morphological, histological, and molecular methods. Histological analysis of the retrieved specimens from nude mice in experimental group showed obvious ectopic bone formation. There were positive expression of osteopontin (OPN) and osteocalcin (OCN) at RNA and protein level. As for the cranial defects, there was complete repair in experimental group, but only partial repair in negative controls. The radiographs, H&E staining, and Masson's trichrome method showed better bone regeneration at experimental sites. Combining osteogenic ASCs with NanoBCP can lead to formation of ectopic new bone. Furthermore, the approach can also stimulate bone regeneration and repair for the large size bone defects.",
        "keywords": [
            "adipose tissue-derived stromal cells",
            "biphasic calcium phosphate nanocomposite",
            "bone formation",
            "osteogenic differentiation",
            "adipose tissue",
            "calcium phosphate",
            "stromal cells"
        ],
        "authors": [
            {
                "name": "Yunfeng Lin",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Tao Wang",
                "org": "Hainan Provincial People's Hospital(Hainan Provincial People's Hospital,People's Hospital of Hainan Province),Haikou,China"
            },
            {
                "name": "Ling Wu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Jing",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xizhe Chen",
                "org": "Kunming Medical College(Kunming Medical College),Kunming,China"
            },
            {
                "name": "Zhiyong Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xiaohui Zheng",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Journal of biomedical materials research. Part A",
        "year": 2007
    },
    "sY25YUla": {
        "id": "sY25YUla",
        "title": "The Role of the Wnt Signaling Pathway in the Osteogenic Differentiation of Human Adipose-derived Stem Cells under Mechanical Stimulation",
        "abstract": "",
        "keywords": [
            "wnt signaling pathway",
            "tensile stress"
        ],
        "authors": [
            {
                "name": "hongming du",
                "org": ""
            },
            {
                "name": "liya wang",
                "org": ""
            },
            {
                "name": "xiaohui zheng",
                "org": ""
            },
            {
                "name": "wei tang",
                "org": ""
            },
            {
                "name": "lei liu",
                "org": ""
            },
            {
                "name": "wei jing",
                "org": ""
            },
            {
                "name": "yunfeng lin",
                "org": ""
            },
            {
                "name": "weidong tian",
                "org": ""
            },
            {
                "name": "jie long",
                "org": ""
            }
        ],
        "venue": "Journal of Hard Tissue Biology",
        "year": 2015
    },
    "H5AQ0aAy": {
        "id": "H5AQ0aAy",
        "title": "Clinical study on repairing depressed fracture of frontal part with hydroxylapatite particulate artificial bone]",
        "abstract": "To study the effect and complication of repairing depressed fracture of frontal part with hydroxylapatite particulate artificial bone.From January 1994 to December 2002, 13 patients were all diagnosed as having depressed fracture of frontal part with clinical and X-ray examinations. The small incision before the hair-edge or local small incision was made. After opening the incision, we performed creeping decollement. Then the hydroxylapatite particulate artificial bone was implanted into the sites of the depressed fracture. The effect and complication were observed with clinical and X-ray examinations in all patients 1 week, 1 month, 3 months after operation.The quantity of hydroxylapatite implanted was 10-30 g. Primary healing was obtained in all cases without any complication. All cases were followed up for 3 months. The contours of the frontal part were restored well.It is a good method to repair depressed fracture of frontal part with hydroxylapatite particulate artificial bone.",
        "keywords": [],
        "authors": [
            {
                "name": "Lei Liu",
                "org": "Department of Dentofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, P. R. China."
            },
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Shengwei Li",
                "org": ""
            }
        ],
        "venue": "Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery",
        "year": 2004
    },
    "ySwkwiqs": {
        "id": "ySwkwiqs",
        "title": "Changes in microRNA-16 expression during adipogenic differentiation of adipose tissue-derived stromal cells",
        "abstract": "Background: The study on regulation adipogenic differentiation of adipose tissue-derived stromal cells (ADSCs) is benefit for artificial control differentiation direction of adipose stromal cells, and promote further understanding of cell differentiation. Objective: To explore the differential expression of microRNA-16 during adipogenic differentiation of ADSCs. Design, Time and Setting: The comparison observation was performed at the State Key Laboratory of Oral Diseases in October 2007 to March 2008. Materials: Eight 30-days-old Sprague-Dawley (SD) rats. Adipogenic-differentiated culture medium [DMEM including dexamethasone(1 \u03bc mol/L), 3-isobutyl-1-methyl xanthine (0.5 mmol/L) and insulin (10 mg/L). Methods: Removed the adipose from yonge SD rats, and treated with density gradient centrifugation and adherent culture to obtained ADSCs. Induced and cultured the third generation cells into adipogenic differentiation with the inductive medium, and the non-induced cells were served as the control group. Main Outcome Measures: The differential expression of microRNA-16 in experimental group at 7 days after adipogenic-differentiation and in the control group were detected by microRNA chip technology. Realtime quantitative PCR was carried out to explore the differentially expression of microRNA-16 during adipogenic differentiation of ADSCs. Results: High-purity ADSCs were acquired successfully. The ADSCs were induced into osteoplastic differentiation, and displayed typical adipocytes changes 7 days after induction. the cells turned to slender fusiform and mixed together, which showed positive PPAR\u03b3 immunohistochemical staining and the lipid droplet was stained orange-red by oil red staining. The expression of microRNA-16 was significant down regulated during adipogenic differentiation, which changed from 56.75 to 90.25. Results of realtime quantitative PCR was concordance with that of microRNA chip technology. Conclusion: The expression of microRNA-16 is significant down regulated during the adipogenic differentiation of ADSCs. Maybe it takes part in adipogenic differentiation of ADSCs.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Ming Heng Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yong Zhang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xiaoy\u00fc Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Tian Wei-dong",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Journal of Clinical Rehabilitative Tissue Engineering Research",
        "year": 2009
    },
    "x9icTU1V": {
        "id": "x9icTU1V",
        "title": "New bone formation enhanced by ADSCs overexpressing hRunx2 during mandibular distraction osteogenesis in osteoporotic rabbits: NEW BONE FORMATION",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weidong tian",
                "org": ""
            },
            {
                "name": "wei tang",
                "org": ""
            },
            {
                "name": "jie long",
                "org": ""
            },
            {
                "name": "jingjing sun",
                "org": ""
            },
            {
                "name": "xiaohui zheng",
                "org": ""
            },
            {
                "name": "liya wang",
                "org": ""
            },
            {
                "name": "lei liu",
                "org": ""
            },
            {
                "name": "wei jing",
                "org": ""
            },
            {
                "name": "yunfeng lin",
                "org": ""
            }
        ],
        "venue": "Journal of Orthopaedic Research",
        "year": 2014
    },
    "EFqGnVzN": {
        "id": "EFqGnVzN",
        "title": "Biphasic calcium phosphate nanocomposite loaded with bone marrow stromal cells for repair of critical cranial defect in rats",
        "abstract": "Background: Traditional bioceramics materials, as the carrier for tissue engineering, have been limited to certain application due to their unsatisfactory performances, such as great fragility, difficult shaping process and in vivo degradation, which will affect the new bone formation and later reconstruction. Objective: To observe the osteogenesis ability of biphasic calcium phosphate nanocomposite (NanoBCP) served as tissue engineered carrier for repairing cranial defect. Design, time and setting: The animal controlled experiment was carried out according to random grouping in the Key Laboratory of Oral Biomedical Engineering, Ministry of Education, Sichuan University from September 2004 to May 2005. Materials: Forty-eight male SD rats, two months old and weighing 180-200 g, were prepared into critical-size defect models in the full-thickness cranial bone. The porosity of NanoBCP scaffold was 60%-80% and the pore size was 100-400 \u03c7 m. Both NanoBCP and autogenous bone marrow stromal cells (BMSCs) were offered by the Key Laboratory of Oral Biomedical Engineering, Ministry of Education, Sichuan University. Methods: All rat models were randomly divided into three groups, and each group contained 16 animals. In NanoBCP/BMSCs group, BMSCs were cultured in inducing liquid containing dexamethasone, antiscorbic acid and \u03b2 -sodium glycerophosphate, then the defects were filled with the NanoBCP/BMSCs composites; In pure NanoBCP group, the defects were filled only with NanoBCP; and blank control rats were filled with nothing. Main outcome measures: At 4, 16 and 24 weeks after implantation, the osteogenesis activity was evaluated by radiographic analysis, gross observation and histological examination. Results: All of 48 SD rats were involved in the result analysis. 1 At 4 and 16 weeks postoperatively, more newly formed bone was found in NanoBCP/BMSCs group, and they were positive for type I collagen immunohistochemical staining. At 24 weeks, cranial defects were completely healed in NanoBCP/BMSCs group, and partly healed in pure NanoBCP group. Blank controls showed no detectable signal of bone defect repair. 2 At 4 and 24 weeks postoperatively, the density of shadow image in cranial defect areas was increased gradually in NanoBCP/BMSCs group, and newly formed bone was close to normal bone; In pure NanoBCP group, the ring low-density was presented in cranial defects and increased along the periphery of the skull, the central domain showed uneven density image. Conclusion: The NanoBCP/BMSCs composites can repair cranial defects effectively.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Tao Wang",
                "org": "Hainan Provincial People's Hospital(Hainan Provincial People's Hospital,People's Hospital of Hainan Province),Haikou,China"
            },
            {
                "name": "Tian Wei-dong",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Li Sheng-wei",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Liao Yun-mao",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Journal of Clinical Rehabilitative Tissue Engineering Research",
        "year": 2008
    },
    "JX8N2Adr": {
        "id": "JX8N2Adr",
        "title": "Sequential surgical treatment for panfacial fractures and significance of biological osteosynthesis.",
        "abstract": "The goal of this retrospective study was to evaluate the efficacy of panfacial fracture repair and to review guidelines for treatment based on AO/Arbeitsgemeinschaft fuer Osteosynthesefragen Association for Study of Internal Fixation theories of biological osteosynthesis. Sixty-eight patients with panfacial fractures were subjected to preoperative X-ray cephalometric analysis and model surgery, followed by open surgical reduction, rigid internal fixation and at least 8 weeks of clinical follow up. A variety of surgical approaches were used, with the 68 patients undergoing a total of 93 surgical procedures. In all but eight patients, the treatment produced satisfactory correction of maxillofacial deformities and restoration of normal function. Among the eight patients whose treatment was not deemed successful, there were two whose facial deformities were not corrected by treatment. In addition, there were five patients with enophthalmos or motor disturbance of the eye that failed to show improvement during the study, and four patients who exhibited signs of limited mouth opening and malocclusion. The systematic and sequential choices of surgical methods were key factors in determining panfacial fracture treatment outcomes. We propose that treatment of bone fractures must take into account the biological characteristics of the damaged bone to facilitate selection of appropriate plate and screw systems and repositioning methods.",
        "keywords": [],
        "authors": [
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Fan Feng",
                "org": ""
            },
            {
                "name": "Jie Long",
                "org": ""
            },
            {
                "name": "Yunfeng Lin",
                "org": ""
            },
            {
                "name": "Hang Wang",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Dental traumatology : official publication of International Association for Dental Traumatology",
        "year": 2009
    },
    "RN2qnGWF": {
        "id": "RN2qnGWF",
        "title": "Construction of recombinant adenovirus vector carrying the mouse Caveolin-1 in gene",
        "abstract": "Objective To construct recombinant adenovirus carrying the mouse dentin caveolin-1 gene using the recombinant adenoviral vector system AdEasy. Methods The cDNA fragment of caveolin-1 was derived from pTKE2-caveolin-1 by restriction enzyme digestion and subcloned into shuttle plasmid pAdtrack-CMV. The resulting plasmid pAdtrack-CMV-cavio/in-1, after linearized by digesting with restriction endonuclease Pme I , was transformed into E. coli 1 BJ5183 which had been transformed by adenoviral backbone plasmid pAdEasy-1. The recombinant plasmid pA.d-caveolin-1 was screened by kanamycin LB plate and then identified by restriction enzyme digestion. The linearized adenovirus plasmid pAd-caveolin-1 was packaged in 293 cells, then the recombinant adenovirus Ad-caveolin-1 was harvested. The expression of green fluorescence protein was observed under fluorescentmicroscope. With further amplification and purification, the titer of recombinant adenovirus was determined. Results The recombinant adenovirus was identified by restriction enzyme digestion analysis and gene sequencing. Cytopathic effect and the expression of GFP were observed in the infected 293 cells. The sequence of caveolin-1 gene insert was the same as that published in the GenBank. The titer of the recombinant adenovirus was 2\u00d7109 pfu/mL. Conclusion The mouse caveolin-1 recombinant adenovirus was constructed successfully by using AdEasy adenovirus system. Cell transfection and expression of exogenous gene can be detected directly by observing the expression of GFP. These results provide the basis for the further study on the role of caveolin-1 gene in other scopes.",
        "keywords": [
            "AdEasy adenovirus vector",
            "Caveolin-1",
            "Green fluorescent protein",
            "Homologous recombination"
        ],
        "authors": [
            {
                "name": "Lin Yang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yong-Hong He",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yong-Dai Shen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xiao-Hui Zheng",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei-Dong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2008
    },
    "WL5Q5ngu": {
        "id": "WL5Q5ngu",
        "title": "Effect of hypoxia on the biological characteristics of human dental follicle cells]",
        "abstract": "This study aimed to investigate the effects of hypoxia on the characteristics of human dental follicle cells (hDFCs).The tissue explant collagenase method was used to isolate hDFCs from young permanent teeth. The immunofluorescence technique was used to detect cell surface markers, and the multi-differentiation potential was detected by multilineage differentiation induction assay. Then, the hypoxic microenvironment was physically mimicked, and the cells were divided into the normoxia group (20%O\u2082) and the hypoxia group (2%O\u2082). The effects of hypoxia on cell migration and proliferation were examined by Transwell chamber test and CCK-8 assay, respectively. The gene and protein expression levels of stemness-related markers at both oxygen concentrations were measured by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot, respectively. After osteogenic induction of both groups, qRT-PCR was performed to evaluate the osteogenesis-related gene, and alizarin red staining was used to assess the formation of mineralized nodules.With the multi-differentiation capacity of osteogenic cells, adipogenic cells, and nerves, hDFCs demonstrate strong stem cell characteristics and possess the criteria of mesenchymal stem cells, which can meet the requirements of seed cells in dental tissue engineering. Hypoxia was conducive to the maintenance of hDFC stemness. Hypoxia promoted the migration and proliferation of hDFCs. The hDFCs were induced to osteogenic differentiation under hypoxic conditions, thereby enhancing osteogenesis.Hypoxic microenvironment plays an important role in maintaining the stemness and promoting the proliferation, migration, and differentiation of hDFCs. Thus, this microenvironment could also serve several important functions in future clinical applications.\u76ee\u7684 \u7814\u7a76\u4f4e\u6c27\u5bf9\u4eba\u7259\u56ca\u7ec6\u80de\uff08hDFCs\uff09\u751f\u7269\u5b66\u7279\u6027\u7684\u5f71\u54cd\u3002\u65b9\u6cd5 \u5229\u7528\u7ec4\u7ec7\u5757\u9176\u6d88\u5316\u6cd5\u4ece\u5e74\u8f7b\u6052\u7259\u4e2d\u5206\u79bb\u57f9\u517bhDFCs\uff1b\u91c7\u7528\u514d\u75ab\u8367\u5149\u6280\u672f\u68c0\u6d4b\u7ec6\u80de\u8868\u9762\u6807\u5fd7\u7269\uff0c\u591a\u5411\u8bf1\u5bfc\u5b9e\u9a8c\u68c0\u6d4b\u7ec6\u80de\u591a\u5411\u5206\u5316\u6f5c\u80fd\uff1b\u6a21\u62df\u4f53\u5916\u4f4e\u6c27\u5fae\u73af\u5883\uff0c\u5c06\u7ec6\u80de\u5206\u4e3a\u5e38\u6c27\u7ec4\uff0820%O\u2082\uff09\u548c\u4f4e\u6c27\u7ec4\uff082%O\u2082\uff09\uff0c\u5206\u522b\u5bf9\u4e24\u7ec4\u7ec6\u80de\u884cTranswell\u5c0f\u5ba4\u8bd5\u9a8c\u68c0\u6d4b\u4f4e\u6c27\u5bf9\u7ec6\u80de\u8fc1\u79fb\u7684\u5f71\u54cd\uff0c\u91c7\u7528CCK-8\u6cd5\u68c0\u6d4b\u4f4e\u6c27\u5bf9\u7ec6\u80de\u589e\u6b96\u7684\u5f71\u54cd\u3002\u901a\u8fc7\u5b9e\u65f6\u5b9a\u91cf\u805a\u5408\u9176\u94fe\u53cd\u5e94\uff08qRT-PCR\uff09\u548cWestern blot\u5206\u522b\u4ece\u57fa\u56e0\u548c\u86cb\u767d\u6c34\u5e73\u68c0\u6d4bhDFCs\u591a\u80fd\u6027\u76f8\u5173\u6807\u5fd7\u7269\u4e8e\u4e0d\u540c\u6c27\u4f53\u79ef\u5206\u6570\u4e0b\u7684\u8868\u8fbe\uff1b\u5206\u522b\u5bf9\u4e24\u7ec4\u7ec6\u80de\u8fdb\u884c\u6210\u9aa8\u8bf1\u5bfc\uff0cqRT-PCR\u68c0\u6d4b\u6210\u9aa8\u76f8\u5173\u57fa\u56e0\uff0c\u831c\u7d20\u7ea2\u67d3\u8272\u8bc4\u4f30\u77ff\u5316\u7ed3\u8282\u7684\u5f62\u6210\u3002\u7ed3\u679c hDFCs\u5177\u6709\u8f83\u5f3a\u7684\u5e72\u7ec6\u80de\u7279\u5f81\uff0c\u5177\u6709\u6210\u9aa8\u3001\u6210\u8102\u53ca\u6210\u795e\u7ecf\u591a\u5411\u5206\u5316\u80fd\u529b\uff0c\u7b26\u5408\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u57fa\u672c\u6807\u51c6\uff0c\u80fd\u591f\u6ee1\u8db3\u7259\u7ec4\u7ec7\u5de5\u7a0b\u6784\u5efa\u5bf9\u79cd\u5b50\u7ec6\u80de\u7684\u9700\u6c42\u3002\u4f4e\u6c27\u6709\u5229\u4e8ehDFCs\u591a\u80fd\u6027\u7684\u4fdd\u6301\uff0c\u540c\u65f6\u4fc3\u8fdb\u4e86hDFCs\u7684\u8fc1\u79fb\u548c\u589e\u6b96\u3002hDFCs\u4e8e\u4f4e\u6c27\u4e2d\u8fdb\u884c\u8bf1\u5bfc\u65f6\uff0c\u5176\u6210\u9aa8\u5206\u5316\u80fd\u529b\u5f97\u5230\u589e\u5f3a\u3002\u7ed3\u8bba \u4f4e\u6c27\u5fae\u73af\u5883\u5bf9\u7ef4\u6301hDFCs\u591a\u80fd\u6027\uff0c\u4fc3\u8fdbhDFCs\u589e\u6b96\u3001\u8fc1\u79fb\u548c\u5206\u5316\u6709\u91cd\u8981\u4f5c\u7528\u3002.",
        "keywords": [
            "differentiation",
            "human dental follicle cells",
            "hypoxia",
            "migration",
            "proliferation"
        ],
        "authors": [
            {
                "name": "Liang Xi",
                "org": "State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Dept. of Oral and Maxillofacial Trauma and Plastic Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Chen Guoqing",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Tian Weidong",
                "org": "State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Dept. of Oral and Maxillofacial Trauma and Plastic Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China."
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2017
    },
    "ORjpPzix": {
        "id": "ORjpPzix",
        "title": "Association analysis between the IRF6 G820A polymorphism and nonsyndromic cleft lip and/or cleft palate in a Chinese population.",
        "abstract": "To investigate whether an association occurred between the IRF6 G820A polymorphism and nonsyndromic cleft lip with or without cleft palate (CL+/-P) or cleft palate only (CPO) in Chinese patients.Case-controlled study at the West China Hospital of Stomatology, Sichuan University, China.A total of 91 patients with cleft lip and/or palate (CL/P) and 96 unrelated, healthy individuals with no family history of CL/P were genotyped.The IRF6 G820A polymorphism was genotyped by restriction digestion of polymerase chain reaction products with BseLI. Chi-square statistics were used to make case-controlled comparisons.The frequency of the A allele was significantly increased and the frequency of the G allele was reduced in CPO patients in comparison with control subjects. The 820GG genotype had a significantly lower frequency in patients with CPO than in controls, with an odds ratio of 0.25 (95% confidence interval, -0.061 to 0.57). No difference in the distribution of genotypes was noted between CL+/-P patients and the total group of CL/P patients compared with controls.The present findings indicate that the 820A allele is more frequent in the Chinese CPO population and may confer an increased risk for CPO in these individuals. The G820A variant may be in linkage disequilibrium with other disorder-causing mutations. CL+/-P or CPO results should be analyzed separately and stratified in future studies.",
        "keywords": [
            "irf6 gene",
            "nonsyndromic cleft lip and/or palate",
            "polymorphism"
        ],
        "authors": [
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xinya Du",
                "org": "Longhua Hospital(Longhua Hospital),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Fan Feng",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jie Long",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yunfeng Lin",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Peng Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association",
        "year": 2009
    },
    "SzwuLdRx": {
        "id": "SzwuLdRx",
        "title": "A study on puncturing the temporomandibular joint cavity of rabbits and withdrawing synovia]",
        "abstract": "The purpose of this study was to study the methods of how to puncture the temporomandibular joint (TMJ) cavity of rabbits and get the synovia.The authors punctured joint cavity and withdrew the synovia from bilateral TMJ cavities of 12 New Zealand rabbits with different methods, such as the traditional puncture method, improved puncture, puncture under X ray, puncture guided by ultrasonography and spiral CT, and withdrawing synovia by micropump.Only one cavity was successfully punctured using the traditional puncture method. A total of 4 cases were successfully punctured using the improved method. X ray and ultrasonography did not locate the TMJ cavity precisely. The spiral CT helped observation and puncture. However, the above methods did not work in collecting synovia. The method of micropump withdrew synovia successfully.The improved method and spiral CT are efficient methods to precisely puncture TMJ cavity. The technique of micropump successfully resolves the problem of withdrawing synovia.",
        "keywords": [],
        "authors": [
            {
                "name": "Dong Wang",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Yisong Li",
                "org": ""
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2003
    },
    "byGCe2Oa": {
        "id": "byGCe2Oa",
        "title": "New bone formation enhanced by ADSCs overexpressing hRunx2 during mandibular distraction osteogenesis in osteoporotic rabbits.",
        "abstract": "Promoting new bone formation during distraction osteogenesis (DO) in elderly patients with osteoporosis is still a challenge. In this study, we investigated the effect of gene therapy using local Runt-related gene 2 on new bone formation during osteoporotic mandibular DO in rabbits. First, we successfully established a mandibular osteoporotic animal model by ovariectomizing rabbits. Second, the right mandibles of the osteoporotic rabbits were distracted after corticotomy. The distraction gap of the rabbits in Group A2 and B2 were injected with Adv-hRunx2-GFP-transfected adipose-derived stromal cells (ADSCs) and Adv-GFP-transfected ADSCs, respectively. Rabbits in Groups C2 (ovariectomized control) and D2 (sham surgery control) were injected with physiologic saline. New-generation bone tissue in the distraction gap was analyzed via plain radiographic examinations, micro-computed tomography, histological examinations, and biomechanical testing at weeks 3, 6, and 9 of the consolidation period. Results of above examinations showed that no ideal new bone formation was observed in Groups B2 and C2, but obvious ideal new bone formation was observed in Group A2 and D2. The results suggested that gene therapy using rhRunx2-modified ADSCs promoted new bone formation during osteoporotic mandibular DO and effectively compensated for the detrimental effects of systemic osteoporosis on new bone formation.",
        "keywords": [
            "runt-related gene 2",
            "adipose-derived stromal cells",
            "bone regeneration",
            "distraction osteogenesis",
            "osteoporosis"
        ],
        "authors": [
            {
                "name": "Jing-Jing Sun",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, 610041, P.R, China; Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, 610041, P.R, China."
            },
            {
                "name": "Xiao-Hui Zheng",
                "org": ""
            },
            {
                "name": "Li-Ya Wang",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            },
            {
                "name": "Wei Jing",
                "org": ""
            },
            {
                "name": "Yun-Feng Lin",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Jie Long",
                "org": ""
            }
        ],
        "venue": "Journal of orthopaedic research : official publication of the Orthopaedic Research Society",
        "year": 2014
    },
    "8bpKh8tb": {
        "id": "8bpKh8tb",
        "title": "Reconstruction of orbital floor fractures: comparison of individual prefabricated titanium implants and calvarial bone grafts.",
        "abstract": "We assessed fresh (< or = 2 weeks) and old (>2 weeks) orbital floor fractures and examined how selection of the implant affected the development of enophthalmos or the treatment of pre-existing enophthalmos. We conducted a retrospective review of 61 cases treated with calvarial bone grafting or individually prefabricated titanium mesh implants. The features of orbital floor fractures and orbital volume (OV) changes were analyzed by a 3-dimensional medical surface rendering image software system. The difference in OV before and after surgery was significant (P < 0.05) in fresh and old fractures treated with either calvarial bone or individually designed titanium mesh. The difference in OV between unaffected and postoperatively affected sides was not significant in the group that received the individually designed titanium mesh, but was significant in the group that received calvarial bone. Spearman rank correlation analysis indicated positive correlations between enophthalmos and postoperative OV changes after implantation of cranial bone in fresh fractures or titanium mesh in fresh and old fractures. The long-term degree of enophthalmos can be predicted with 3-dimensional medical surface rendering. Individual digitally designed titanium mesh is the proper choice of implant material to recover precise OV in fresh or older orbital fractures.",
        "keywords": [
            "orbital floor",
            "enophthalmos",
            "image reconstruction",
            "material",
            "fractures",
            "titanium"
        ],
        "authors": [
            {
                "name": "Lijuan Guo",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Fan Feng",
                "org": ""
            },
            {
                "name": "Jie Long",
                "org": ""
            },
            {
                "name": "Pengfei Li",
                "org": ""
            },
            {
                "name": "Wei Tang",
                "org": ""
            }
        ],
        "venue": "Annals of plastic surgery",
        "year": 2009
    },
    "dk7CkI7T": {
        "id": "dk7CkI7T",
        "title": "Effect of insulin-like growth factor I and basic fibroblast growth factor on proliferation and differentiation of human dental papilla mesenchymal cells",
        "abstract": "BACKGROUND: Previous research has indicated that both insulin-like growth factor I (IGF-I) and basic fibroblast growth factor (bFGF) play an important role in cell proliferation and differentiation. However, the effect on biological characteristics of human dental papilla mesenchymal cells (hDPMCs) still remains unclear. OBJECTIVE: To research the effect of IGF-I and bFGF on the proliferation and differentiation of hDPMCs. METHODS: hDPMCs were isolated and cultured in DMEM/F12 culture media containing 1% or 10% fetal bovine serum. The fourth-passaged hDPMCs were incubated in culture media containing 0, 0.1, 1, 10 and 100 \u03bcg/L bFGF and 0, 25, 50, 75 and 100 \u03bcg/L IGF-I(0 \u03bcg/L as control group), respectively. At 96 hours after culture, proliferative activity was measured with MTT assay. The corresponding growth factor culture media were used in 10 \u03bcg/L bFGF group, 100 \u03bcg/L IGF-Igroup, bFGF + IGF-I group, and control group, respectively. At days 1, 3, 5, and 7 after culture, the proliferative activity was detected using MTT assay, and alkaline phosphatase (ALP) activity was measured using modified enzyme kinetics method. RESULTS AND CONCLUSION: At the 0-100 \u03bcg/L mass concentration scope, both bFGF and IGF-Icould accelerate proliferation of hDPMCs, and the proliferation ability of bFGF was superior to that of IGF-?; moreover, the combination of bFGF and IGF-Icaused a synergetic action to proliferation of hDPMCs. The maximal valid concentration of bFGF was 10 \u03bcg/L, and the maximal action concentration of IGF-Iwas 100 \u03bcg/L. At 0-7 days, the effect of bFGF on the ALP activity of hDPMCs was not obvious, but the effect of IGF-Ion ALP activity of hDPMCs became greater with the time passing; furthermore, the combination of bFGF and IGF-Icould generate a synergetic action on increasing the ALP activity.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Jia M. Xie",
                "org": "Taizhou People's Hospital(Taizhou People's Hospital),,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Journal of Clinical Rehabilitative Tissue Engineering Research",
        "year": 2010
    },
    "jRw5PrAE": {
        "id": "jRw5PrAE",
        "title": "Secretory Factors From Rat Adipose Tissue Explants Promote Adipogenesis and Angiogenesis: SFAE promote adipogenesis and angiogenesis",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xiangchen qiao",
                "org": ""
            },
            {
                "name": "mei yu",
                "org": ""
            },
            {
                "name": "feng li",
                "org": ""
            },
            {
                "name": "hang wang",
                "org": ""
            },
            {
                "name": "weihua guo",
                "org": ""
            },
            {
                "name": "weidong tian",
                "org": ""
            },
            {
                "name": "jie li",
                "org": ""
            }
        ],
        "venue": "Artificial Organs",
        "year": 2014
    },
    "b3xW69wz": {
        "id": "b3xW69wz",
        "title": "Adipogenous potential of rat adipose tissue-derived endothelial cells under adipogenic induction",
        "abstract": "Objective:To study the adipogenous potential of endothelial cells derived from SD rat adipose tissue.Methods:The subcutaneous adipose tissue was obtained from the fold inguen of four SD rats, then digested with collagenase type \u2160 and cultured in endothelial medium (Gibco) for seven days. When the cells appeared endothelial characteristics identified by transmission electron microscopy and immunocytochemical staining with factor anti \u2167 antibody, the cellss were cultured in adipogenic inducing medium (supplemented with insulin, 1-methyl-3-isobutylxanthine, indomethine and dexamethasone) for seven days and stained with Oil Red O.Results:The adipose tissue derived endothelial cells uniformly had characteristic cobblestone morphology and arrangement. After 7-10 d culture in endothelial medium,95% of the cells were factor \u2167 positive and Weibel-Palade body was found in cytoplasm of some cells.After seven days of adipogenic induction, about 85% of the cells displayed accumulation of lipid vacuoles detected by Red Oil O staining.Conclusion:Endothelial cells from adipose tissue can be induced to differentiate into adipose cells.",
        "keywords": [
            "Endothelial cells",
            "Adipose cell",
            "Cell culture",
            "Adipose stromal cells"
        ],
        "authors": [
            {
                "name": "Lin Yunfeng",
                "org": ",et al.Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu , China"
            },
            {
                "name": "Tian Weidong",
                "org": ",et al.Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu , China"
            },
            {
                "name": "Chen Xizhe",
                "org": ",et al.Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu , China"
            }
        ],
        "venue": "Journal of Practical Stomatology",
        "year": 2006
    },
    "zAqmXY1G": {
        "id": "zAqmXY1G",
        "title": "Characterization of ectomesenchymal cells isolated from the first branchial arch during multilineage differentiation.",
        "abstract": "Ectomesenchymal cells isolated from the first branchial arch have the potential to differentiate into a variety of cell lineages both in vitro and in vivo. This study was aimed to confirm the plasticity of multilineage differentiation with molecular and cellular characterization. Monolayer cultures of ectomesenchymal cells harvested from the first branchial arch primordia in embryonic day 9.5 BALB/c mice were passaged 3 times before analysis. Staining with antibodies against S-100, p75 and vimentin suggested that the population of stem cells originated from ectomesenchyme, with few contaminating cells stained for cytokeratin. Then, cells were transferred to adipogenic, osteogenic, chondrogenic and odontogenic media. The initiation of controlled differentiation was determined with histological assays, and the expression of tissue-specific genes was detected using immunocytochemical staining and reverse transcription polymerase chain reaction. The adipogenic ectomesenchymal cells showed accumulation of lipid vacuoles and expression of lipoprotein lipase and peroxisome proliferator-activated receptor gamma(2). Following osteoinduction, the fibroblast-like cells became cuboidal and formed mineralized nodules. In addition, the expression of mRNA encoding osteocalcin and osteopontin proved osteogenesis at the molecular level. Chondrogenic lineage expressed collagen type II, aggrecan and Sox9 with a low level of collagen type I in monolayer culture. Odontogenesis was determined by dentin sialophosphoprotein, collagen type I and dentin matrix protein 1 expression. Therefore, we have demonstrated that ectomesenchymal cells from the first branchial arch are capable of extensive multilineage differentiation in vitro, controllable by the culture environment. This makes them a relevant and valuable source of stem cells for research of craniofacial development and tissue engineering of restoration.",
        "keywords": [
            "first branchial arch",
            "mesenchymal stem cells",
            "stem cell differentiation",
            "cranial neural crest cells",
            "craniofacial development",
            "peroxisome proliferator activated receptor",
            "tissue engineering",
            "mesenchymal stem cell",
            "reverse transcription polymerase chain reaction",
            "lipoprotein lipase",
            "stem cell",
            "neural crest cell"
        ],
        "authors": [
            {
                "name": "Zhengbin Yan",
                "org": ""
            },
            {
                "name": "Yunfeng Lin",
                "org": ""
            },
            {
                "name": "Xiaohui Jiao",
                "org": ""
            },
            {
                "name": "Zhiyong Li",
                "org": ""
            },
            {
                "name": "Ling Wu",
                "org": ""
            },
            {
                "name": "Wei Jing",
                "org": ""
            },
            {
                "name": "Ju Qiao",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            },
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Xiaohui Zheng",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Cells, tissues, organs",
        "year": 2006
    },
    "sG4pQS0v": {
        "id": "sG4pQS0v",
        "title": "Hertwig's epithelial root sheath cells regulate osteogenic differentiation of dental follicle cells through the Wnt pathway.",
        "abstract": "The development of periodontal ligament-cementum complex (PLCC) originates from the interaction between epithelial cells of Hertwig's epithelial root sheath (HERS) and mesenchymal cells of the dental follicle. While previous studies have suggested that the Wnt pathway is involved in osteogenic differentiation of dental follicle cells (DFCs) during tooth root development, its involvement in the interaction between DFCs and HERS cells (HERSCs) in tooth root mineralization remains unclear. Here, we investigated the hypothesis that HERSCs control osteogenic differentiation of DFCs via the Wnt pathway. We found that during co-culture with HERSCs, DFCs exhibited a greater tendency to form mineralized nodules. Moreover, under these conditions, DFCs expressed high levels of cementoblast/osteoblast differentiation-related markers, such as bone sialoprotein (BSP) and osteocalcin (OCN), the periodontal ligament phenotype-related gene type I collagen (COL1), and \u03b2-catenin (CTNNB1), a core player in the canonical Wnt pathway. In contrast, expression in DFCs of alkaline phosphatase (ALP) was greatly decreased in the presence of HERSCs. Expression of CTNNB1 in DFCs was stimulated by Wnt3a, a representative canonical member of the Wnt family of ligands, but suppressed by Dickkopf1 (DKK1), a Wnt/CTNNB1 signaling inhibitor. Furthermore, in the presence of treated dentin matrix (TDM), differentiation of DFCs was enhanced by Wnt3a when they were in direct contact with HERSCs, but was curtailed by DKK1. Taken together, these results indicate that during tooth root formation, HERSCs induce osteogenic differentiation of DFCs in a process involving the Wnt pathway and the dentin matrix. Our study not only contributes to our understanding of tooth root development and diseases of tooth root mineralization, but also proffers a novel potential strategy for controlling mineralization during tooth root regeneration.",
        "keywords": [
            "dfcs",
            "herscs",
            "osteogenic differentiation",
            "tdm",
            "wnt pathway"
        ],
        "authors": [
            {
                "name": "Yaling Yang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Yaneng Ge",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Guoqing Chen",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Zhiling Yan",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Mei Yu",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Lian Feng",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Zongting Jiang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weihua Guo",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Pedodontics, West China School of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Chengdu, 610041 Sichuan Province, China."
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, China."
            }
        ],
        "venue": "Bone",
        "year": 2014
    },
    "mcpKVFHr": {
        "id": "mcpKVFHr",
        "title": "The study of cell biocompatibility of new pattern biphasic calcium phosphate nanocomposite in vitro]",
        "abstract": "To study the cell biocompatibility of porous biphasic calcium phosphate nanocomposite in vitro.Bone marrow mesenchymal cell (BMSCs) obtained from SD rat bone marrow were in vitro induced and proliferated. Afler their osteoblast phenotypes were verified, BMSCs were seeded onto prepared porous biphasic calcium phosphate nanocomposite (Experiment group) and common porous hydroxyapatite (Control group). The cell adhesion was evaluated by scanning electron microscope. Synthesis of alkaline phosphatase enzyme (ALP) and osteocalcin were detected and cell cycle was detected by flow cytometry.BMSCs could fully attach to and extend on the material in experiment and control group, Moreover, experiment group were superior to control group in adhesion, proliferative abilities and osteogenic activity.BMSCs can differentiate to osteoblast phenotype; the porous biphasic calcium phosphate nanocomposite as bone tissue engineering scaffold has good cell biocompatibility.",
        "keywords": [
            "tissue engineering",
            "bone marrow stromal cells",
            "porous biphasic calcium phosphate nanocomposite"
        ],
        "authors": [
            {
                "name": "Tao Wang",
                "org": "Key Lab. of Oral Biomedical Engineering of Ministry of Education, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Wei-Dong Tian",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            },
            {
                "name": "Xi-Zhe Cheng",
                "org": ""
            },
            {
                "name": "Yun-Mao Liao",
                "org": ""
            },
            {
                "name": "Sheng-Wei Li",
                "org": ""
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2005
    },
    "lalg6gLL": {
        "id": "lalg6gLL",
        "title": "Biomechanical study on repairing bone defect with composite of bovine bone morphogenetic protein and porous hydroxyapatite",
        "abstract": "To investigate the mechanical property (shear strength, bending strength and compressive strength) and the interface combinative ability of the composite of bovine bone morphogenetic protein (bBMP) and porous hydroxyapatite (HA) with different pore diameter. HA 1 (\u03a6100-300 \u03bc m) and HA 2(\u03a6130-500 \u03bc m) were used as carriers of bBMP(5mg). The 4 types material (HA 1, HA 2, bBMP /HA 1, bBMP /HA 2) were implanted into the femur of 10 dogs (2 dogs each group) for the shear test and 15 dogs (3 dogs each group) for the bending test and compressive test. The shear strength of all kinds of materials were increased as time went on and the shear strength of bBMP/HA 1 was highest in four materials. The bending strength of bBMP /HA 1 was close to the normal femur in the 24 th week. The compressive strength of all materials was lower than the cortex of the dog's femur until 24 th week. The compressive strength of bBMP /HA 1 was the highest in four types. The compressive strength of HA 2 and bBMP /HA 2 was decreased after implantation. Implant of bBMP /HA with 100-300 \u03bc m diameter had strong bonding with the host bone, and had better mechanical properties than that with 130-500 \u03bc m diameter. So the porous bBMP /HA (\u03a6 100-300 \u03bc m) could be a useful graft material due to its strength.",
        "keywords": [
            "Biomechanics",
            "BMP (bone morphogenetic protein)",
            "HA (Hydroxyapatite)",
            "Pore"
        ],
        "authors": [
            {
                "name": "Hang Wang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Mengshi Chen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Key Engineering Materials",
        "year": 2007
    },
    "9PDMPmt8": {
        "id": "9PDMPmt8",
        "title": "Odontoblast-like cell phenotype differentiation of cranial neural crest stem cell in vivo]",
        "abstract": "To investigate the feasibility of tooth regeneration by seeding cranial neural crest stem cell (CNCSC) in vivo.Cranial neural tubes, dissected from mouse E9 d, were explanted onto fibronectin-coated dishes. CNCSC emigrated from the explanted neural tubes, and were cultured in a free-serum medium containing modified DMEM/F12. CNCSC, induced by FGF8, BMP2, TGFbeta1 and dentin matrix non-collagen protein (DMNCP), were cultured with collagen/chitosan, and implanted into the subcutaneous part of immunodeficiency mouse. The expression of collagen I/dentin sialophosphoprotein (DSPP) was analyzed by immunocytochemistry.With the scaffolds destroying, columnar cells possessing polarized nuclei and matrix produced by cells were showed in some regions. Immunohistochemical staining demonstrated that collagen type I and DSPP were expressed throughout the cytoplasm and matrix produced by cells.By tissue engineering approach, our experiments further verify the odontoblast-like cell phenotype differentiation of CNCSC in vivo.",
        "keywords": [
            "cranial neural crest odontoblast-like cell scaffolds tooth regeneration"
        ],
        "authors": [
            {
                "name": "Hong-Bing Jiang",
                "org": ".State Key Laboratory of Oral Diseases,West China Stomatological Hospital,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Wei-Dong Tian",
                "org": ".State Key Laboratory of Oral Diseases,West China Stomatological Hospital,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Lei Liu",
                "org": ".State Key Laboratory of Oral Diseases,West China Stomatological Hospital,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Wei Tang",
                "org": ".State Key Laboratory of Oral Diseases,West China Stomatological Hospital,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Xiao-Hui Zheng",
                "org": ".State Key Laboratory of Oral Diseases,West China Stomatological Hospital,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Xi-Zhe Chen",
                "org": ".State Key Laboratory of Oral Diseases,West China Stomatological Hospital,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2008
    },
    "LYFoGY1b": {
        "id": "LYFoGY1b",
        "title": "in situ Expression of Transforming Growth Factor \u03b21 in the Process of Induction Chemotherapy for Oral Squamous Cell Carcinoma",
        "abstract": "Objective: To study the differential expression of transforming growth factor \u03b21 (TGF\u03b21) in oral carcinoma and stroma lymphocytes by induction chemotherapy and inquire into the mechanism of TGF\u03b21 information transmission. Methods: Forty cases of oral tumor were treated with MTX, CDDP and PYM via subcutaneous implantable drug pump. in situ hybridization method was adopted to detect the expression of TGF\u03b21 mRNA. Results: The positive expression of TGF\u03b2 1 mRNA was enhanced in oral carcinoma (P<0. 05). After the induction chemotherapy via subcutaneous implantable drug pump, not only the expression level of TGF\u03b21 in malignant cells of invading front zone was up-regulated (P<0. 05), but the expression level of stroma lymphocytes was higher than before. Conclusion: These data demonstrated that TGF\u03b21 not only has transforming potential, but also enhances the malignant progression of oral carcinoma. It was clear that TGF \u03b2 1 can act as a tumor suppressor and a significant stimulator of T-cell-mediated tumor cytotoxity as well.",
        "keywords": [
            "Induction chemotherapy",
            "Oral cancer",
            "TGF \u03b21"
        ],
        "authors": [
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei-dong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Sheng-wei Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "You-chao Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2004
    },
    "nHQZKl7v": {
        "id": "nHQZKl7v",
        "title": "Heterotopic chondrogenesis of human adipose tissue-derived stromal cells loading on alginate gel]",
        "abstract": "To isolate and chondro-inductive culture of human adipose tissue-derived stromal cells and to study their heterotopic chondrogenesis by loading them on alginate gel.Liposuction human adipose tissues were minced and digested with collagenase type I. The obtained stromal cells were primarily cultured in BGJb medium for ten days. Secondary harvested cells were cultured in DMEM-F12 medium supplemented with 10%FBS, 6.25 mg/L insulin, 10 mg/L TGF-beta1, 50 mg/L of freshly prepared L-ascorbate for 14 days. After in vitro assay of chondrogenic phenotypes, the cells at density of 10(10)/L were mixed with 1.2% alginate sodium and 102 mmol/L CaCl(2). The cross-linking cell-alginate gel were injected into four BALB/C athymic mice subcutaneously (1 ml for each mouse). Meanwhile, the auto-controls were set by injecting equal dose of simple alginate gel and pure cells in two opposite buttocks of the same mouse subcutaneously. Two mice were sacrificed at fourth and eighth week postoperatively and all samples were removed, fixed, embedded in paraffin and cut into sections of 5 micro m thick. HE staining, Alcian blue and modified Masson's trichrome staining were employed to observe chondrogenesis histologically.Alcian blue and immunocytochemical staining revealed chondroitin sulfate and collagen II in cell matrix after having been chondro-inductive cultured for 14 days. At intervals of fourth and eighth week, heterotopic chondrogenesis is (cartilage formed) within cell-alginate injected sites were found in all mice but negatively in auto-controls. Histologically the hypertrophic chondrocytes were among cartilage matrix in different staining. All alginate gel and solitory cells absorbed within two to three weeks postoperatively in auto-controls.It seems that stromal cells derived from human adipose tissue presents a potential for chondrogenic differentiation.",
        "keywords": [],
        "authors": [
            {
                "name": "Xi-zhe Chen",
                "org": "Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu 610041, China. chenxizhe@263.net"
            },
            {
                "name": "Yun-feng Lin",
                "org": ""
            },
            {
                "name": "Ju Qiao",
                "org": ""
            },
            {
                "name": "Wei-dong Tian",
                "org": ""
            },
            {
                "name": "Run-liang Cheng",
                "org": ""
            },
            {
                "name": "Sheng-wei Li",
                "org": ""
            }
        ],
        "venue": "Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology",
        "year": 2004
    },
    "eb7ndXHY": {
        "id": "eb7ndXHY",
        "title": "Serratus anterior composite flaps for reconstruction of large-area oral and maxillofacial defects: a new neuromuscular flap.",
        "abstract": "Large area defects in the maxillofacial field are difficult to restore with sufficient esthetic and functional outcome. This study was to assess the feasibility of using serratus anterior composite flaps for reconstruction of large-area oral and maxillofacial tissue defects and to determine subsequent effects on neuromuscular function. Six patients with severe maxillofacial deformities were treated with serratus anterior composite flaps. The neurovascularized pedicle of each flap retained the long thoracic nerve to supply motor innervation. The long thoracic nerve was anastomosed with a branch of the facial nerve. The remaining fine branches of the facial nerve were separated interfascicularly and intrafascicularly, and then implanted within the border of the serratus anterior muscle. Transplanted flaps survived in all patients without vascular crisis. At the 12-month follow-up examinations, patients were able to close their eyes, wrinkle their forehead, and blow through pursed lips using the reconstructed mimetic muscles. The free serratus anterior composite flap has different digitations of the serratus anterior and motor nerve innervations, which is an attractive choice for reconstruction of large defects of oral and maxillofacial tissue. The nerve anastomosis and facial nerve replantation technique may protect the pedicle from atrophy of the transferred flap. Facial motion can be animated by neurotization or reinnervation in-growth in the neurotized slips of the serratus.",
        "keywords": [
            "facial nerve replantation",
            "nerve anastomosis",
            "oral and maxillofacial defects",
            "serratus anterior composite flap"
        ],
        "authors": [
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Jie Long",
                "org": ""
            },
            {
                "name": "Fan Feng",
                "org": ""
            },
            {
                "name": "Lijuan Guo",
                "org": ""
            },
            {
                "name": "Chao Gao",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Annals of plastic surgery",
        "year": 2009
    },
    "sE5ivFlN": {
        "id": "sE5ivFlN",
        "title": "Screening for Genes Affecting Tooth Shape Formation",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "lei liu",
                "org": ""
            },
            {
                "name": "weidong tian",
                "org": ""
            },
            {
                "name": "miaomiao yang",
                "org": ""
            },
            {
                "name": "jie long",
                "org": ""
            },
            {
                "name": "wei jing",
                "org": ""
            },
            {
                "name": "yongqing ma",
                "org": ""
            },
            {
                "name": "wei tang",
                "org": ""
            }
        ],
        "venue": "Advanced Science Letters",
        "year": 2012
    },
    "4C1BU5nF": {
        "id": "4C1BU5nF",
        "title": "Beta -transduction repeat containing protein expressed in tooth germs and ameloblast and odontoblast of different stage of tooth development]",
        "abstract": "The Sonic hedgehog signalling peptide has been demonstrated to play important roles in the growth and patterning of the tooth development. This study aims on whether the antagonist beta-transduction repeat containing protein of Sonic hedgehog signal transduction expressed in tooth germs ameloblast and odontoblast or not.The mouse embryo heads of different developmental stages of E10.5, E13.5, E14.5, E16.5, E18.5 and P0, P3, P6 after birth were acquired fixed with 4% paraformaldehyde for 48 hours, embeded with Paraffin and examined using LsAB (labelled streptavidin-biotin) method to observe the beta-TrCP expression pattern in tooth germs, ameloblast and odontoblast.It was demonstrated that beta-TrCP expressed in oral epithelium, tooth bud, mesenchymal cell cytoplasm of ameloblast and odontoblast of different stage of tooth development.beta-TrCP expressed from early stage to later stage of murine tooth development. And these findings provide the evidence of antagonist regulatory pathways for shh in teeth development.",
        "keywords": [],
        "authors": [
            {
                "name": "Yong-Dai Shen",
                "org": "Key. Laboratory of Oral Biomedical Engineering of Ministry of Education, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Wei-Dong Tian",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            },
            {
                "name": "Yong-Houg He",
                "org": ""
            },
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Xiaohui Zheng",
                "org": ""
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2007
    },
    "DtKBGB77": {
        "id": "DtKBGB77",
        "title": "Hemiarthroplasty of the Shoulder Joint Using a Custom-Designed High-Density Nano-Hydroxyapatite/Polyamide Prosthesis With a Polyvinyl Alcohol Hydrogel Humeral Head Surface in Rabbits: Hemiarthroplasty using n-HA/PA with PVA",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weidong tian",
                "org": ""
            },
            {
                "name": "weihua guo",
                "org": ""
            },
            {
                "name": "xiaohui zheng",
                "org": ""
            },
            {
                "name": "hang wang",
                "org": ""
            },
            {
                "name": "ding bai",
                "org": ""
            },
            {
                "name": "jun guo",
                "org": ""
            },
            {
                "name": "yongwen guo",
                "org": ""
            }
        ],
        "venue": "Artificial Organs",
        "year": 2014
    },
    "8DD9pzOo": {
        "id": "8DD9pzOo",
        "title": "An Experimental Study of miRNA-27b Expression during Adipogenic Differentiation by Adipose-Derived Stem Cells",
        "abstract": "Objective: To investigate miRNA involved in adipogenic differentiations of adipose -derived stem cells (ADSCs), and the regulation mechanisms of ADSCs\u2019osteogenic differentiation thereof. Methods: ADSCs were obtained from the inguinal fat pads of SD rats by type I collagenase digestion and density gradient centrifugation. Adipogenic differentiation of the third generation of ADSCs was induced with the adipogenic medium (\u03b1-MEM medium supplemented with 100 mL/L fetal bovine serum, 1 \u03bcmol/L dexamethasone, 10 \u03bcmol/L insulin, 200 \u03bcmol/L indomethacin, and 0.5 mmol/L 3 -isobutyl -1 - methylxanthine) prior to applying miRNA chip technology for examination of miRNA-27b. Real-time quantitative polymerase chain reaction (real-time PCR) was used to detect the expression of miRNA-27b. Moreover, the bioinformatics analysis was utilized to discuss adipogenic -related function of the miRNA -27b. Results: An in vitro model of adipogenic -inductive differentiation of rat ADSCs was successfully constructed. The miRNA-27b was identified by the miRNA chip technology as being down-regulated during adipogenic differentiation of ADSCs. Real-time PCR analysis confirmed the decreased expression of miRNA-27b. Conclusion: The expression of miRNA-27b was significantly down-regulated during adipogenic differentiation of ADSCs, which indicated miRNA-27b may be involved in adipogenic differentiation of ADSCs. The miRNA-27b may promote adipogenic differentiation of ADSCs through regulating its target gene PPAR\u03b3 expression.",
        "keywords": [
            "Sprague-Dawley",
            "small interfering polymerase chain reaction rats",
            "stem cells adipose tissue RNA"
        ],
        "authors": [
            {
                "name": "CHEN Jianlin",
                "org": " State Key Laboratory of Oral Diseases, Sichuan University, Chengdu , China"
            },
            {
                "name": "LI Xiaoyu",
                "org": " State Key Laboratory of Oral Diseases, Sichuan University, Chengdu , China"
            },
            {
                "name": "ZHANG Yong",
                "org": " State Key Laboratory of Oral Diseases, Sichuan University, Chengdu , China"
            },
            {
                "name": "TIAN Weidong",
                "org": " State Key Laboratory of Oral Diseases, Sichuan University, Chengdu , China"
            },
            {
                "name": "LIU Lei",
                "org": " State Key Laboratory of Oral Diseases, Sichuan University, Chengdu , China"
            }
        ],
        "venue": "Tianjin Medical Journal",
        "year": 2009
    },
    "NEKnLsRo": {
        "id": "NEKnLsRo",
        "title": "In vitro three-dimensional development of mouse molar tooth germs in a rotary cell culture system.",
        "abstract": "In vitro tooth germ cultivation is an effective method to explore the mechanism of odontogenesis. The three-dimensional rotary cell culture system (RCCS) is typically used to culture simulated organs such as cartilage, skin, and bone. In this study, we established an in vitro tooth germ culture model using RCCS to investigate whether RCCS could provide an appropriate environment for tooth germ development in vitro.Mandibular first molar tooth germs from 1-day post-natal mice were cultured in RCCS for 3, 6, and 9 days. Tooth germ development was monitored via histology (hematoxylin & eosin staining), stereoscopic microscopy, and quantitative real-time PCR (RT-PCR).Tooth germs cultured in RCCS maintained their typical spatial shape. Blood vessels were maintained on the dental follicle surface surrounding the crown. After cultivation, thick layers of dentin and enamel were secreted. Compared with tooth germs grown in jaw, the tooth germs grown in RCCS exhibited no significant difference in DMP1 or FGF10 expression at all time points.Use of RCCS enhanced the development of tooth germs and allowed the tooth germs to maintain their spatial morphology. These results indicate that RCCS may be an effective culture system to investigate the mechanism of tooth development.",
        "keywords": [],
        "authors": [
            {
                "name": "Liang Sun",
                "org": "Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China."
            },
            {
                "name": "Chao Yang",
                "org": ""
            },
            {
                "name": "Yaneng Ge",
                "org": ""
            },
            {
                "name": "Mei Yu",
                "org": ""
            },
            {
                "name": "Guoqing Chen",
                "org": ""
            },
            {
                "name": "Weihua Guo",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children",
        "year": 2014
    },
    "EUXc5pQh": {
        "id": "EUXc5pQh",
        "title": "Expression and roles of syndecan-4 in dental epithelial cell differentiation.",
        "abstract": "Syndecan-4 (SDC4), a transmembrane heparan sulfate proteoglycan, acts as a signal transducer. It affects the growth and differentiation of a number of tissues and organs. However, the specific mechanisms through which SDC4 regulates the differentiation of dental epithelial cells (amelogenesis) and tooth development remains largely unknown. In the present study, to identify the SDC4-regulated processes in dental epithelial cells, the SDC4 expression pattern was examined in mouse molar and postnatal incisor tooth germs during the late bell stage of development. Small interfering RNA (siRNA) was designed for this study and used to downregulate SDC4 expression in the rat dental epithelial cell line, HAT-7. The results revealed that SDC4 was mainly present in the oral epithelium, the dental epithelial cells of enamel organs in the molars and the cervical loops in the incisors. When the inner enamel epithelial cells gave rise to ameloblasts, however, the loss of SDC4 expression was evident. SDC4 was also expressed in stratum intermedium (SI) cells in the incisors and in dental mesenchymal cells adjacent to the cervical loops in molars (E18) and postnatal incisors. Fibroblast growth factor 10 (FGF10) promoted proliferation and slightly decreased cell differentiation. The knockdown of SDC4 using specific siRNA led to a decrease in cell proliferation and a highly significant increase in amelogenin, ameloblastin, kallikrein 4 and matrix metalloproteinase 20 expression, molecules that are known to participate in the formation of enamel. These effects were attenuated by FGF10, which upregulated SDC4 expression. Taken together, these results suggest that SDC4 participates in amelogenesis, and FGF10 may modulate dental epithelial cell behaviors through the regulation of SDC4 expression.",
        "keywords": [
            "cancer",
            "apoptosis",
            "molecular medicine",
            "oncology",
            "gene",
            "cell cycle",
            "cell"
        ],
        "authors": [
            {
                "name": "Zhiling Yan",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Guoqing Chen",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Yaling Yang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Liang Sun",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Zongting Jiang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Lian Feng",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Mei Yu",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Weihua Guo",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            }
        ],
        "venue": "International journal of molecular medicine",
        "year": 2014
    },
    "dER90fLe": {
        "id": "dER90fLe",
        "title": "Development of a functional mandibular model]",
        "abstract": "This study was conducted to establish a functional mandibular biomechanical model for use in the follow-up biomechanical study of the integrated and fractured mandible. The integrated and dry human mandible was used, and the corresponding maxilla and cranial base was duplicated by resin and plaster. 2-mm silicon rubber was used for simulation of the temporomandibular joint (TMJ) disc. A simulated TMJ and physiological mandibular model was developed by four pairs of muscular loadings (Masseter= 180 N, Temporalis = 190 N, Medial Pterygoideus = 120 N, Lateral Pterygoideus = 40 N) in each muscular center, and the functional loading corresponding with physiological condition was reflected and simulated more realistically when compared with that of the previously reported mandibular models which were developed by occlusion loading or by only one pair of muscles loading. In summary, we have established a functional mandibular model which can be used to analyze the biomechanical behavior in various functional conditions.",
        "keywords": [
            "mandible biomechanical model functionality"
        ],
        "authors": [
            {
                "name": "Hang Wang",
                "org": "Department of Oral and Maxillofacial Surgery,West China College of Stomatology,Sichuan University,Chengdu ,China;Key Lab of Biomechanics,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Mengshi Chen",
                "org": "Key Lab of Biomechanics,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Oral and Maxillofacial Surgery,West China College of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Wei Tang",
                "org": "Department of Oral and Maxillofacial Surgery,West China College of Stomatology,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi",
        "year": 2006
    },
    "tJLMmzPU": {
        "id": "tJLMmzPU",
        "title": "Diagnosis and treatment of cranial-maxillofacial embedding fractures",
        "abstract": "Objective To study the principles and methods for diagnosing and treating the cranial-maxillofacial embedding fractures. Methods Thirty-four cases with cranial-maxillofacial embedding fractures were admitted and treated from July 2002 to July 2006 in our hospital. The diagnosis, treatment and prognosis were reviewed and analyzed. Results All the patients remarkably obtained normal appearances and sound function. Conclusion CT and 3D reconstruction can supply much significant references to the diagnosis and treatment of cranial-maxillofacial embedding fractures. According to the severity of the deformity and dysfunction, the cranial embedding fractures should be treated with or without operations. All the orbital and maxillary embedding fractures should be treated with operations as soon as possible.",
        "keywords": [
            "embedding fractures",
            "treatment",
            "cranial-maxillofacial",
            "diagnosis"
        ],
        "authors": [
            {
                "name": "DONG Hai",
                "org": "Department of Traumatic & Plastic Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu , China"
            },
            {
                "name": "LIU Lei",
                "org": "Department of Traumatic & Plastic Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu , China"
            },
            {
                "name": "XIAO Jin-gang",
                "org": "Department of Traumatic & Plastic Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu , China"
            },
            {
                "name": "LI Xiao-yu",
                "org": "Department of Traumatic & Plastic Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu , China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "Department of Traumatic & Plastic Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu , China"
            },
            {
                "name": "YANG Liang",
                "org": "Department of Traumatic & Plastic Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu , China"
            }
        ],
        "venue": "Acta Academiae Medicinae Militaris Tertiae",
        "year": 2007
    },
    "TfWoP2FV": {
        "id": "TfWoP2FV",
        "title": "Chemical synthesis of biodegradable poly-para-dioxanone and its application for mandibular fracture fixation]",
        "abstract": "To observe mandibular fracture healing after synthesized bioabsorable poly-para-dioxanone (PDS) ligature fixation.Para-dioxanone monomer was prepared by chemical reactions of metallic sodium, ethylene glycol and other raw materials. PDS was synthesized by polymerizing the purified para-dioxanone in the presence of catalyst under the conditions of negative pressure and certain temperature. PDS ligature was obtained by processing the polymer into small granules, drying and melt-extruding through a spinnerette. Eighteen adult male New Zealand rabbits were assigned randomly into two groups. After mandibular fracture models were created, reductions of the artificial fractures were accomplished by means of transosseous PDS ligatures on each of 12 rabbits in experimental group. While the other six rabbits without any internal fixation were set as control. Schedules for killing were arranged to give postoperative samples at two-week interval till 12th week.Radiographical and histological examinations demonstrated that all fractures fixed with PDS ligatures healed without any complication. Periosteal and cartilaginous osteogenesis was observed in newly formed external callus. In contrast, bone fragment migration and the consequent nonunion occurred in the control group. PDS ligature degraded and absorbed without interference with osseous union and healing. The tensile strength reduction of PDS ligature was prior to its absorption in vivo.The synthesized PDS is a colorless, flexible, themoplastic and monofilament fiber, which can be sterilized by ethylene oxide embalmment without serious loss of tensile strength. It seems that the application of this macromolecular material in internal fixation is of great worth for further study.",
        "keywords": [],
        "authors": [
            {
                "name": "Yong Peng",
                "org": "Oral Department, Central Hospital of Longgang, Shenzhen 518116, China."
            },
            {
                "name": "Xizhe Chen",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2003
    },
    "xOZZnZWg": {
        "id": "xOZZnZWg",
        "title": "A biomechanical analysis of titanium miniplates used for treatment of mandibular symphyseal fractures with the finite element method.",
        "abstract": "This study aimed to evaluate the stress distribution and stress shielding effect of titanium miniplates used for the treatment of symphyseal fractures using finite element (FE) analysis.Two 3-D FE models of symphyseal fractured mandibles reduced by technique 1, reduction with a single miniplate, and technique 2, reduction with 2 miniplates, respectively, were developed. Three basic loading conditions were simulated.The ratios of stress shielding of miniplates were different. Ratios of the lower miniplates in technique 2 were much higher than the upper miniplates and the miniplates in technique 1 during all conditions, and that value of the lower miniplate gained a maximum value of 83.34% during left unilateral molar clenching. The stress areas were concentrated on the central section of the miniplates. However, the stress distribution varied with masticatory conditions.The study demonstrated that miniplate stress distribution and stress shielding effect ratio were affected not only by the way in which the mandible was loaded but also by the number of the miniplates fixing the fracture.",
        "keywords": [
            "finite element method",
            "titanium"
        ],
        "authors": [
            {
                "name": "Baohui Ji",
                "org": "State Key Laboratory of Oral Disease, Sichuan University, Chengdu, PR China"
            },
            {
                "name": "Chun Wang",
                "org": "State Key Laboratory of Oral Disease, Sichuan University, Chengdu, PR China"
            },
            {
                "name": "Lei Liu",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, PR China"
            },
            {
                "name": "Jie Long",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, PR China"
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, PR China"
            },
            {
                "name": "Hang Wang",
                "org": ""
            }
        ],
        "venue": "Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics",
        "year": 2010
    },
    "2HMXXrwx": {
        "id": "2HMXXrwx",
        "title": "Research on the effect of extract of dentin matrix on the differentiation of dental pulp cells]",
        "abstract": "To investigate the effects of human treated dentin matrix (hTDM) extracellular matrix molecules on odontogenetic and neural differentiation of human dental pulp cells (hDPCs) with an aim to find an effective method to collect extracellular matrix molecules to contribute to reparation dental-pulp complex with dentin defects.hDPCs were obtained and biological characteristics such as source of cells and multi-differentiation potentials were assessed using immunofluorescence and flow cytometry. Fabrication of hTDM extracts and hDPCs was induced with it for 1 week. The odontogenetic differentiation associated genes were tested by qRT-PCR. Results qRT-PCR results showed that cells were higher expression of odontogenetic differentiation associated genes ALP, OPN, OCN, BSP, DMP-1, DSP, beta-III tubulin.The method of extracting extracellular matrix molecules from dentin matrix was effective. The extract liquid provides a suitable microenvironment for odontogenetic and neural differentiation of hDPCs and contributes to reparation dental-pulp complex.",
        "keywords": [
            "dentin matrix extracellular matrix molecules dental pulp cells differentiation"
        ],
        "authors": [
            {
                "name": "Cai-yun Cui",
                "org": ".1.Regenerative Medicine Research Center,West China Hospital,Sichuan University,Chengdu ,China;National Engineering Laboratory for Oral Regenerative Medicine,Sichuan University,Chengdu ,China;State Key Laboratory of Oral Diseases,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Yang Bo",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine,Sichuan University,Chengdu ,China;State Key Laboratory of Oral Diseases,Sichuan University,Chengdu ,China;Department of Oral and Maxillofacial Surgery,West China Stomatological Hospital,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Gang Chen",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine,Sichuan University,Chengdu ,China;State Key Laboratory of Oral Diseases,Sichuan University,Chengdu ,China;Department of Oral and Maxillofacial Surgery,West China Stomatological Hospital,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Lei Sheng",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine,Sichuan University,Chengdu ,China;State Key Laboratory of Oral Diseases,Sichuan University,Chengdu ,China;Department of Oral and Maxillofacial Surgery,West China Stomatological Hospital,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Jian-Ping Zhao",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine,Sichuan University,Chengdu ,China;State Key Laboratory of Oral Diseases,Sichuan University,Chengdu ,China;Department of Oral and Maxillofacial Surgery,West China Stomatological Hospital,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Xiang-Chen Qiao",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine,Sichuan University,Chengdu ,China;State Key Laboratory of Oral Diseases,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Wei-Hua Guo",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine,Sichuan University,Chengdu ,China;State Key Laboratory of Oral Diseases,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Wei-Dong Tian",
                "org": ".1.Regenerative Medicine Research Center,West China Hospital,Sichuan University,Chengdu ,China;National Engineering Laboratory for Oral Regenerative Medicine,Sichuan University,Chengdu ,China;State Key Laboratory of Oral Diseases,Sichuan University,Chengdu ,China;Department of Oral and Maxillofacial Surgery,West China Stomatological Hospital,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2013
    },
    "WXLwrUMp": {
        "id": "WXLwrUMp",
        "title": "Establishment of sequential software processing for a biomechanical model of mandibular reconstruction with custom-made plate.",
        "abstract": "The aim of this study is to describe the sequential software processing of computed tomography (CT) dataset for reconstructing the finite element analysis (FEA) mandibular model with custom-made plate, and to provide a theoretical basis for clinical usage of this reconstruction method. A CT scan was done on one patient who had mandibular continuity defects. This CT dataset in DICOM format was imported into Mimics 10.0 software in which a three-dimensional (3-D) model of the facial skeleton was reconstructed and the mandible was segmented out. With Geomagic Studio 11.0, one custom-made plate and nine virtual screws were designed. All parts of the reconstructed mandible were converted into NURBS and saved as IGES format for importing into pro/E 4.0. After Boolean operation and assembly, the model was switched to ANSYS Workbench 12.0. Finally, after applying the boundary conditions and material properties, an analysis was performed. As results, a 3-D FEA model was successfully developed using the softwares above. The stress-strain distribution precisely indicated biomechanical performance of the reconstructed mandible on the normal occlusion load, without stress concentrated areas. The Von-Mises stress in all parts of the model, from the maximum value of 50.9MPa to the minimum value of 0.1MPa, was lower than the ultimate tensile strength. In conclusion, the described strategy could speedily and successfully produce a biomechanical model of a reconstructed mandible with custom-made plate. Using this FEA foundation, the custom-made plate may be improved for an optimal clinical outcome.",
        "keywords": [
            "reconstructed mandible",
            "mandible",
            "ct dataset",
            "dicom format",
            "mandibular reconstruction",
            "finite element analysis",
            "iges format",
            "biomechanical model",
            "custom-made plate",
            "3-d fea model",
            "sequential software processing",
            "von-mises stress",
            "fea foundation",
            "mandibular model",
            "biomechanics"
        ],
        "authors": [
            {
                "name": "Peng Li",
                "org": ""
            },
            {
                "name": "Youchao Tang",
                "org": ""
            },
            {
                "name": "Jia Li",
                "org": ""
            },
            {
                "name": "Longduo Shen",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Wei Tang",
                "org": ""
            }
        ],
        "venue": "Computer Methods and Programs in Biomedicine",
        "year": 2013
    },
    "bIzasBIf": {
        "id": "bIzasBIf",
        "title": "The Optimal Time Point to Dismantle the Distractor During the Mandibular Distraction Osteogenesis in Goats",
        "abstract": "Objective: To investigate the optimal time point to dismantle the distractor during mandibular distraction osteogenesis in goats. Methods: The right side mandibles of 12 goats were distracted after corticortomy, and divided into 3 groups in random. The first group was sacrificed at the 6th week of consolidation, the second group was sacrificed at the 8th week of consolidation, the third group was sacrificed at the 10th week of consolidation, and the left side mandibles of 4 goats from above were randomly selected as the control. The biomechanical properties of the new generation bone at 6th, 8th, 10th week of consolidation and the mandible of control group at the same time were detected by three point bending test and axial compressive test, and the changes of the biomechanical strength of the new generation bone during the period of consolidation were studied. Results: The biomechanical strength of the new generation bone increased with the pass of the consolidation time, the biomechanical strength of the 6th week group and the 8th week group showed significant difference with the control (P<0.05), but that of 10th week group showed no significant difference with the control (P>0.05). Conclusion: The biomechanical strength of the new generation bone at 10th week after distraction showed no significant difference with the normal, and the 10th week of consolidation may be the optimal time point for the distractor dismantled.",
        "keywords": [
            "distraction osteogenesis",
            "dismantle",
            "mandible",
            "distractor"
        ],
        "authors": [
            {
                "name": "LONG Jie",
                "org": " The Key Lab of Biomechanics, Sichuan University, Chengdu ; The West China College of Stomatology, Sichuan University, ChengDu , Sichuan Province, China"
            },
            {
                "name": "FAN Yu-bo",
                "org": " The Key Lab of Biomechanics, Sichuan University, Chengdu "
            },
            {
                "name": "TIAN Wei-dong",
                "org": " The West China College of Stomatology, Sichuan University, ChengDu , Sichuan Province, China"
            },
            {
                "name": "WU Ling",
                "org": " The Key Lab of Biomechanics, Sichuan University, Chengdu "
            },
            {
                "name": "ZHENG Xiao-hui",
                "org": " The West China College of Stomatology, Sichuan University, ChengDu , Sichuan Province, China"
            }
        ],
        "venue": "Journal of Oral and Maxillofacial Surgery",
        "year": 2006
    },
    "LPMdcXL3": {
        "id": "LPMdcXL3",
        "title": "Changes in MicroRNA-21 Expression during Adipogenic Differentiation Of Adipose Tissue-derived Stromal Cells",
        "abstract": "Objective:To explore the differential expression of microRNA-16 during adipogenic differentiation of adipose derived stromalcells(ADSCs).Methods:The adipose was removed from eight 30-day-old Sprague-Dawle SD rats,and was treated with density gradient centrifugation and adherent culture to obtain ADSCs.The third generation cells were induced and cultured into adipogenic differentiation with Adipogenic-differentiated culture medium[DMEM including dexamethasone(1\u03bcmol.L-1),3-isobutyl-1-methyl xanthine(0.5 mmol.L-1)-1and insulin(10 mg.L-1),and the non-induced cells were served as the control group.Results:The adipogenic differentiation of ADSCs was confirmed by microscopy,staining with Oil red O and immunocytochemical detection of PPAR\u03b3.The miRNA-21 was identified by the miRNA chip technology as being down-regulated during adipogenic differentiation of ADSCs.Real -time PCR analysis confirmed the decreased expression of miRNA-21.Conclusion:The miRNA-21 expression will significantly decrease in the adipogenic differentiation process of ADSCs,which maybe involved in the regulation process of adipogenic differentiation of ADSCs.",
        "keywords": [
            "adipogenic differentiation",
            "real-time pcr",
            "microrna chip",
            "adipose derived stromal cells",
            "microrna-21",
            "rna",
            "adipose tissue",
            "gene expression",
            "cell differentiation"
        ],
        "authors": [
            {
                "name": "WANG Wei-xin",
                "org": " State Key Laboratory of Oral Diseases,Sichuan University,Chengdu ,China; Department of Oral&Maxillofacial Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "ZHANG Yong",
                "org": " State Key Laboratory of Oral Diseases,Sichuan University,Chengdu ,China"
            },
            {
                "name": "LI Xiao-yu",
                "org": " State Key Laboratory of Oral Diseases,Sichuan University,Chengdu ,China"
            },
            {
                "name": "LONG Jie",
                "org": " State Key Laboratory of Oral Diseases,Sichuan University,Chengdu ,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": " Department of Oral&Maxillofacial Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "TANG Wei",
                "org": " Department of Oral&Maxillofacial Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "WANG Hang",
                "org": " Department of Oral&Maxillofacial Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "ZHENG Xiao-hui",
                "org": " State Key Laboratory of Oral Diseases,Sichuan University,Chengdu ,China"
            },
            {
                "name": "LIU Lei",
                "org": " Department of Oral&Maxillofacial Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Progress in Modern Biomedicine",
        "year": 2009
    },
    "Bd944mnQ": {
        "id": "Bd944mnQ",
        "title": "Investigation and analysis of facial function of patients with maxillofacial injuries in the Wenchuan earthquake",
        "abstract": "Objective To analyze retrospectively maxillofacial injuries with emphasis on facial function after the Wenchuan earthquake in Sichuan province,so as to provide reference on patients' treatment after earthquake.Methods All the 419 patients with maxillofacial injuries after the earthquake were investigated concerning facial function and a database was used to analyze the results.Results A wide variety of functional disturbances was seen among all the 419 patients,such as nerve injury,occlusal disturbance,limitation of mouth opening,diplopia.Limitation of mouth opening was the most vulnerable.Conclusion Functional disturbances resulting from maxillofacial injuries caused by earthquake did not have obvious differentiation from others,and the ratio varies with the kind injuries.",
        "keywords": [
            "Wenchuan earthquake",
            "functional disturbance",
            "maxillofacial injury"
        ],
        "authors": [
            {
                "name": "Wu Hao",
                "org": "Dept.of Traumatic and Plastic Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Li Rui",
                "org": "Dept.of Traumatic and Plastic Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Wang Hang",
                "org": "Dept.of Traumatic and Plastic Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Guo Lijuan",
                "org": "Dept.of Traumatic and Plastic Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Sheng Lei",
                "org": "Dept.of Traumatic and Plastic Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Tang Wei",
                "org": "Dept.of Traumatic and Plastic Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Liu Lei",
                "org": "Dept.of Traumatic and Plastic Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Long Jie",
                "org": "Dept.of Traumatic and Plastic Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Jing Wei",
                "org": "Dept.of Traumatic and Plastic Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Tian Weidong",
                "org": "Dept.of Traumatic and Plastic Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "International Journal of Stomatology",
        "year": 2012
    },
    "pvQW3dO9": {
        "id": "pvQW3dO9",
        "title": "Three-dimensional finite element analysis of mechanical stress in symphyseal fractured human mandible reduced with miniplates during mastication.",
        "abstract": "In this study we tried to analyze the stress distribution in a symphyseal fractured human mandible reduced by 2 different methods--reduction with 1 miniplate or with 2 miniplates--by using finite element (FE) analysis, and then compared the results with an intact mandible.Three-dimensional FE models of an intact mandible and symphyseal fractured mandibles reduced by 2 fixation methods were developed to analyze mandibular stress distribution and bite forces under 2 basic loading conditions, namely, clenching in the intercuspal position and left unilateral molar clenching. Groups of parallel vectors were used to simulate 9 pairs of masticatory muscles involved in the 2 static biting tasks.Stress distributions in reduced mandible with 1 or 2 miniplates were more or less different from that of the intact mandible. The maximum stress occurred at the biting point. Meanwhile, the subcondylar region was a stress-bearing area. During left unilateral molar clenching, bite forces obviously reduced after fracture. Bite force and the stress distribution pattern in the mandible reduced with 2 miniplates were closer to that in the intact mandible.It is suggested that the effect of the miniplates in stabilizing the continuity-broken mandible influence the restorations of the stress distribution pattern and bite force. Two miniplates have a biomechanical advantage over 1 miniplate on these restorations.",
        "keywords": [
            "finite element analysis",
            "mechanical stress",
            "three dimensional"
        ],
        "authors": [
            {
                "name": "Hang Wang",
                "org": "State Key Laboratory of Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Baohui Ji",
                "org": ""
            },
            {
                "name": "Wentao Jiang",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            },
            {
                "name": "Ping Zhang",
                "org": ""
            },
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Yubo Fan",
                "org": ""
            }
        ],
        "venue": "Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons",
        "year": 2010
    },
    "eWdarnsQ": {
        "id": "eWdarnsQ",
        "title": "An experimental study on gene transfection of human interleukin-1 receptor antagonist gene into chondrocytes of temporomandibular joint]",
        "abstract": "The purpose of this study was to investigate methods and expression of the recombinant human interleukin-1 receptor antagonist gene transfected into chondrocytes of temporomandibular joints (TMJ).Chondrocytes derived from the TMJ of 5-7 months old human fetus were transfected by recombinant human interleukin-1 receptor antagonist gene via cationic liposome (Lipefectine) as a medium. The expressing level of hIL-1ra protein was detected using immunocytochemistry and enzyme-linked immunosorbent assay (ELISA).The positive results of the immunocytochemistry were found. The positive expression was detected in the cell plasma and the cell culture supernatant, and there was significant difference between the cells with and without gene transfection (P < 0.01).This feasible method provides experimented evidence for the future gene therapy of temporomandibular joint osteoarthrosis.",
        "keywords": [],
        "authors": [
            {
                "name": "Yisong Li",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Dong Wang",
                "org": ""
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2003
    },
    "sigB0C9D": {
        "id": "sigB0C9D",
        "title": "Repairing critical size calvarial defects in rats with the complex of bone marrow mesenchymal stem cells and alginate gel",
        "abstract": "Background: Based on the previous study, the complex of alginate gel and bone marrow mesenchymal stem cells (BMSCs) can induce chondrogenesis in vivo and secrete type II collagen. Objective: To investigate the effect of repairing a rat model of critical size calvarial defects using autogenous BMSCs and alginate gel. Design, Time and Setting: A paired controlled study was performed from January 2004 to February 2008 in State Key Laboratory of Oral Diseases, Sichuan University. Materials: BMSCs were mixed with 1.2% algin and then added into the Calcium chloride solution to prepare the complex of BMSCs and alginate gel. Methods: A total of 24 SD rats were used. Full thickness cranial plate defects at a diameter of 5 mm were created on the both sides of rat's skull. The complex of BMSCs and alginate gel (the experiment side) and only alginate gel (the control side) were implanted into the defects of 24 rats. After 4 weeks and 8 weeks postoperatively, the animals were sacrificed and the specimen were taken to make the examinations. Main Outcome Measures: Osteogenesis was determined using X-ray detection, histological examination was observed with hematoxylin-eosin stain and Masson trichrome stain, the ultrastructure was detected with transmission electron microscope, immunohistochemical examination of collagen I and III was also performed. Results: All 24 animals entered the result analysis. X-ray results showed that compared with the control side, the defect verge of the experiment side had a significantly higher density of calcified performance. Histology and immunohistochemistry tests showed that the experiment side appeared the histological characteristics of interlace bone and a great amount of new bone, in which the structure resembled mature born. Conclusion: The complex of BMSCs and alginate gel can repair the critical size calvarial defect.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Chen Run-liang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yan Feng Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Li Sheng-wei",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Tian Wei-dong",
                "org": "People's Hospital(People's Hospital,Tianjin People's Hospital),Tianjin,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Journal of Clinical Rehabilitative Tissue Engineering Research",
        "year": 2008
    },
    "7BNodUiC": {
        "id": "7BNodUiC",
        "title": "Stress distribution of mandible under different loading and biting condition]",
        "abstract": "To study the stress distribution of intact mandible, especially that of the mandibular angle under different muscle loading and biting condition.Develop a more accurate, more objective mandibular model, measure the different stress patterns on the outer surface of the mandible by strain gauges due to different biting sites (INC and ICP) and different loading methods (masseter, temporalis and four pairs of muscles).It was found that the strain in the zone of mandibular angle is more markedly under masseter loading; that the strain in the zone of anterior mandibular ramus is more markedly under temporalis loading; and that the stress in the zone of mentum becomes a tension because of the medial pterygoid under the load of four pairs of muscles. During anterior teeth biting, the stress of mandible angle is larger than that of the bilateral molar biting. When an occlusal load is on the ipsilateral molars, there is a reversal result of the stress direction in the upper line of the mandibular angle.Different muscular loading and biting condition can change the stress distribution of the mandible. It is important to develop a functional model of human mandible to study its complex biomechanics behavior.",
        "keywords": [
            "biomechanics",
            "loading condition",
            "mandible"
        ],
        "authors": [
            {
                "name": "Hang Wang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Meng-shi Chen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei-dong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Sheng-wei Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2004
    },
    "TRb0ULfF": {
        "id": "TRb0ULfF",
        "title": "Compound alginate gelatin and bone marrow mesenchymal stromal cells for the in vivo construction of chondrogenesis secreting type II collagen",
        "abstract": "AIM:To investigate the feasibility of chondrogenesis by alginate gelatin as the scaffold and rats' bone marrow mesenchymal stromal cells (BMSCs) as seed cells chondrogenicly induced in vitro. METHODS: The experiment was conducted in the Key Laboratory of Oral Biomedical Engineering of Ministry of Education, Sichuan University between January 2004 and February 2006. Thirty-two adult male SD rats were randomly assigned to experimental and control groups with 16 animals in each group. After isolated and cultured to the third passage, the BMSCs of the experimental group were induced by transforming growth factor \u03b2 and other inducing factors for 10 days and combined with algin, which was added calcium chloride to form alginate gelatin, and injected into the hypodermic tissue of the backs of rats. The control group was only injected alginate. Half of the animals were killed at the 4th and 8th weeks after the operation, respectively to perform the immunohistochemical examination and in situ hybridization for type \u2161 collagen. RESULTS: All 32 rats were involved in the result analysis. In the experimental group, type \u2161 collagen was found in the immunohistochemical examination and in situ hybridization positive at the 4th and 8th weeks after the operation, while in the control group, it presented negative. CONCLUSIONS: It is proved both in the level of protein and gene expression that the compound constructed by alginate gelatin as scaffold and BMSCs as seed cells could express type \u2161 collagen, which is the metabolizing characteristic of cartilage, indicating it is an ideal approach for the construction of tissue engineered cartilage.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Runliang Chen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Tao Wang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Shengwei Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Journal of Clinical Rehabilitative Tissue Engineering Research",
        "year": 2007
    },
    "rstRfrDx": {
        "id": "rstRfrDx",
        "title": "Differential expression of signaling pathways in odontogenic differentiation of ectomesenchymal cells isolated from the first branchial arch.",
        "abstract": "The aim of this study was to screen for differential expression of signaling pathways in odontogenic differentiation of ectomesenchymal cells isolated from the first branchial arch of embryonic day 10 (E10) mice by real time RT-PCR microarray. Observations of cellular morphology, immunocytochemistry, and RT-PCR were used to identify the cell source. A real time RT-PCR microarray was then used to detect the differential expression of signaling pathways in cells dissected from animals at two different developmental stages. These assays identified 25 up-regulated genes and 16 down-regulated genes involved in odontogenic differentiation of the ectomesenchymal cells of the first branchial arch. They represented the main members of Wnt, Hedgehog, TGF-\u03b2, NF-\u03baB, and LDL signaling pathways. This study determined that these signaling pathways are important for odontogenic differentiation of ectomesenchymal cells of the first branchial arch.",
        "keywords": [
            "Ectomesenchymal cell",
            "Dental papilla",
            "Differentiation",
            "Signal transduction pathway",
            "Microarray"
        ],
        "authors": [
            {
                "name": "Yongchun Yu",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 People\u2019s Republic of China"
            },
            {
                "name": "Mingheng Li",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 People\u2019s Republic of China"
            },
            {
                "name": "Jie Sun",
                "org": "Department of Orthodontics, West China College of Stomatology, Sichuan University, Chengdu, 610041 People\u2019s Republic of China"
            },
            {
                "name": "Miaomiao Yang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 People\u2019s Republic of China"
            },
            {
                "name": "Jie Long",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 People\u2019s Republic of China"
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 People\u2019s Republic of China"
            },
            {
                "name": "Wei Tang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 People\u2019s Republic of China"
            },
            {
                "name": "Tangxin Li",
                "org": "Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, 510055 People\u2019s Republic of China"
            },
            {
                "name": "Lei Liu",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 People\u2019s Republic of China"
            }
        ],
        "venue": "Molecular and cellular biochemistry",
        "year": 2011
    },
    "LeQHMdOE": {
        "id": "LeQHMdOE",
        "title": "Necessity of intraoperative three-dimensional navigation for low lumbar spine: a randomized controlled study]",
        "abstract": "To compare the accuracy of lower lumbar pedicle screw placement at different levels with or without navigation system.A prospective randomized controlled trial was conducted for patients undergoing open lumbar surgery with pedicle screws at both L4 and L5 levels from March 2011 to May 2012. The accuracy of pedicle screws at L4 and L5 level were evaluated by three-dimensional postoperative computed tomography (CT). There was no apparent violation of pedicle or < 2 mm perforation of pedicle in non-violation group while \u2265 2 mm perforation of pedicle in violation group.A total of 188 patients were recruited and assigned randomly into navigation (n = 47) and control (n = 141) groups. Two groups did not differ in estimated blood loss volume, length of hospital stay, Japanese Orthopedics Association (JOA) score or JOA recovery rate (P > 0.05). Navigation group had a longer operative duration (P < 0.05). At L4 level, 93/94 screws (98.9%) in navigation group and 273/282 screws (96.8%) in control group did not violate pedicle (P > 0.05). At L5 level, 93/94 screws (98.9%) in navigation group and 260/282 screws (92.2%) in control group did not violate pedicle. Thus navigation could achieve a higher accuracy at L5 level (P < 0.05).The profile of L5 pedicle at coronal plane is tilting oval. Screw may easily violate medioinferior part of pedicle and cause injures of nerve root. For improving the accuracy and safety of pedicle screw at L5 level, we recommend using intraoperative three-dimensional navigation for spondylolisthesis or facet hypertrophy, iliac cohesion or junior operator.",
        "keywords": [],
        "authors": [
            {
                "name": "xiaoxue han",
                "org": "Department of Spine Surgery, Beijing Jishuitan Hospital, Beijing 100035, China."
            },
            {
                "name": "weidong tian",
                "org": "Department of Spine Surgery, Beijing Jishuitan Hospital, Beijing 100035, China; Email: Tianweijst@vip.163.com."
            },
            {
                "name": "Bo Liu",
                "org": "Department of Spine Surgery, Beijing Jishuitan Hospital, Beijing 100035, China."
            },
            {
                "name": "deng he",
                "org": "Department of Spine Surgery, Beijing Jishuitan Hospital, Beijing 100035, China."
            },
            {
                "name": "ning li",
                "org": "Department of Spine Surgery, Beijing Jishuitan Hospital, Beijing 100035, China."
            },
            {
                "name": "Yanwei L\u00fc",
                "org": "Department of Spine Surgery, Beijing Jishuitan Hospital, Beijing 100035, China."
            },
            {
                "name": "Kai Yan",
                "org": "Department of Spine Surgery, Beijing Jishuitan Hospital, Beijing 100035, China."
            },
            {
                "name": "Peihao Jin",
                "org": "Department of Spine Surgery, Beijing Jishuitan Hospital, Beijing 100035, China."
            }
        ],
        "venue": "Zhonghua yi xue za zhi",
        "year": 2015
    },
    "x26ZTN0J": {
        "id": "x26ZTN0J",
        "title": "Odontoblast-like cell phenotype differentiation of cranial neural crest stem cell in vivo",
        "abstract": "Objective To investigate the feasibility of tooth regeneration by seeding cranial neural crest stem cell (CNCSC) in vivo. Methods Cranial neural tubes, dissected from mouse E9 d, were explanted onto fibronectin-coated dishes. CNCSC emigrated from the explanted neural tubes, and were cultured in a free-serum medium containing modified DMEM/F12. CNCSC, induced by FGF8, BMP2, TGF\u00df1 and dentin matrix non-collagen protein (DMNCP), were cultured with collagen/chitosan, and implanted into the subcutaneous part of immunodeficiency mouse. The expression of collagen I /dentin sialophosphoprotein (DSPP) was analyzed by immunocytochemistry. Results With the scaffolds destroying, columnar cells possessing polarized nuclei and matrix produced by cells were showed in some regions. Immunohistochemical staining demonstrated that collagen type I and DSPP were expressed throughout the cytoplasm and matrix produced by cells. Conclusion By tissue engineering approach, our experiments further verify the odontoblast-like cell phenotype differentiation of CNCSC in vivo.",
        "keywords": [
            "Cranial neural crest",
            "Odontoblast-like cell",
            "Scaffolds",
            "Tooth regeneration"
        ],
        "authors": [
            {
                "name": "Hongbing Jiang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xiaohui Zheng",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xizhe Chen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Journal of Sichuan University (Medical Science Edition)",
        "year": 2008
    },
    "hkf8WMbG": {
        "id": "hkf8WMbG",
        "title": "The use of human acellular dermal matrix in the prevention of infra-auricular depressed deformities and Frey's syndrome following total parotidectomy.",
        "abstract": "The aim of the study was to explore whether human acellular dermal matrix (ADM) implantation could prevent infra-auricular depressed deformities and Frey's syndrome following total parotidectomy.We analyzed 41 cases of total parotidectomy (control group) and 29 cases of simultaneous ADM implantation following total parotidectomy (ADM group) for infra-auricular depressed deformities and the presence of gustatory flushing or sweating. The follow-up periods ranged from 6 months to 7 years.Facial contours and bilateral symmetry improved after surgery in the ADM group. In the control group, an infra-auricular depressed deformity was evident in all 41 cases. Frey's syndrome was recorded in 1 patient (3.4%) from the ADM group and 14 patients (34.1%) from the control group. No cases of immune rejection, infection, hematoma, or salivary fistula were observed in either group.The use of ADM could reduce postoperative facial contour deformities and Frey's syndrome following total parotidectomy.",
        "keywords": [],
        "authors": [
            {
                "name": "Wen Luo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xiaohui Zheng",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lin Chen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Jing",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jie Long",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Oral surgery, oral medicine, oral pathology and oral radiology",
        "year": 2012
    },
    "tISt1MWk": {
        "id": "tISt1MWk",
        "title": "Expression of human VEGF165 gene in rat bone marrow stromal cells in vitro]",
        "abstract": "The purpose of this study was to evaluate the feasibility of VEGF165 gene transfection into bone marrow stromal cells and make the groundwork of VEGF gene therapy for the revascularization of bone tissue engineering.Bone marrow stromal cells (BMSC) were cultured in vitro, and were tested for the dexamethasone-induced potential to form mineralized-like tissue in culture in the presence of ascorbic acid and beta-glycerophosphate. The vector pcDNA3.1-VEGF165 was transfected into bone marrow stroma cells with the method of liposome mediated or Sofast transfectam reagent. The expression level of human VEGF165 in the transformed cells was detected by immunocytochemistry.The percent of the positive cells after VEGF165 gene transfection mediated by liposome and cationic polymer was 11.34 and 11.42 respectively. There was no significant difference in gene transfer efficacy between liposome and cationic polymer mediated gene delivery. While the percent of the number of survival cells after gene transfection was 74.60 and 85.88 respectively, the cytoxity of liposome was a little higher than that of cationic polymer.The experiment demonstrated that rhVEGF165 was successfully expressed in BMSC. This result could serve as a basis for the next step of revascularization of bone tissue engineering.",
        "keywords": [
            "vascular endothelial growth factor gene transfection bone marrow stromal cells"
        ],
        "authors": [
            {
                "name": "Xiao-feng Bai",
                "org": "Department of Oral and Mazillofacial Sugery, West China School of Stomatology, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Wei-dong Tian",
                "org": ""
            },
            {
                "name": "Xi-zhe Chen",
                "org": ""
            },
            {
                "name": "Zhi-yong Li",
                "org": ""
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2005
    },
    "wRBE9QE5": {
        "id": "wRBE9QE5",
        "title": "Gene expression profiling of Cx3cl1 in bone marrow mesenchymal stem cells by osteogenic induction.",
        "abstract": "Cx3cl1, also called fractalkine, is located at 19p12, and encodes the chemokine (C-X3-C motif) ligand 1 protein. This protein contains 393 amino acids, and is the only member of the chemokine CX3C subfamily. CX3CR1 is the specific receptor of Cx3cl1, and the binding of this ligand and its receptor participates in a variety of physiological and pathological processes. Through employing microarray technology we demonstrated for the first time that Cx3cl1 was upregulated in osteogenic-induced rat bone marrow mesenchymal stem cells (BMSCs). To analyze the gene expression profiling of Cx3cl1 in osteogenic-induced rat BMSCs at different times, real-time quantitative polymerase chain reaction (real-time PCR) was used to assay Cx3cl1 mRNA. The results showed that the expression of Cx3cl1 in osteogenic-induced rat BMSCs increased consistently for 28 days with a peak at day 21, and Cx3cl1 may be correlated with osteogenic differentiation of BMSCs. Based on bioinformatic analyses, we hypothesize that Cx3cl1 may be beneficial to the formation of the osteoplastic microenvironment by regulating cellular distribution and aggregation, and by promoting cellular mutual induction and paracrine. Cx3cl1 may also be involved in osteogenic differentiation and bone formation of BMSCs through an increase in Runx2 transcription by activating p38 mitogen-activated protein kinase (MAPK).",
        "keywords": [
            "mesenchymal stem cell"
        ],
        "authors": [
            {
                "name": "Jingang Xiao",
                "org": ""
            },
            {
                "name": "Hai Dong",
                "org": ""
            },
            {
                "name": "Yao Wu",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            }
        ],
        "venue": "Omics : a journal of integrative biology",
        "year": 2009
    },
    "Mnvk2T7s": {
        "id": "Mnvk2T7s",
        "title": "Establishment of a culture system of chick embryo for mouse tooth germ development]",
        "abstract": "To establish a new culture system for mouse tooth germs in chick embryo.The mandibular first molar germ fragments of 15 embryonic days' Kunming mouse embryo were implanted into the lateral mesenchyme of 4-5 days' chick embryo wing buds in ove. Eggs were reincubated and implanted tissues were examined by histochemistry.The cultured tooth germ development continued from cap stage to latest bell stage. The ameloblast and the odontoblast all differentiated maturely and secreted matrix.4-5 days' wing buds chick embryo could serve as developing the mouse tooth germs and demonstrate well physiological process of differentiation and morphogenesis.",
        "keywords": [],
        "authors": [
            {
                "name": "Zheng-bin Yan",
                "org": "Key. Laboratory of Oral Biomedical Engineering Ministry of Education, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Wei-dong Tian",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            },
            {
                "name": "Jin-qiu Hou",
                "org": ""
            },
            {
                "name": "Xi-zhe Chen",
                "org": ""
            },
            {
                "name": "Zhi-yong Li",
                "org": ""
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2004
    },
    "CzxKgT1Y": {
        "id": "CzxKgT1Y",
        "title": "Cells isolated from cryopreserved dental follicle display similar characteristics to cryopreserved dental follicle cells.",
        "abstract": "Dental follicle tissue is a promising resource of mesenchymal stem cells for cytotherapeutic approaches and tissue engineering applications. There are two procedures for banking of human dental follicle stem cells have been reported. Conventional method requires cell isolation, expansion and immediate cryopreservation. Whereas dental follicle stem cells can be isolated from cryopreserved dental follicle fragments. The aim of this study was to compare the characteristics of dental follicle cells isolated from cryopreserved fragments (DFCs-CF) with dental follicle cells recovered from cryopreserved cells (DFCs-CC). Dental follicle fragments obtained after mechanical disaggregation were divided into two parts, with one part maintained in culture, while another part underwent cryopreservation. Dental follicle fragments and dental follicle cells from fresh tissue were stored in liquid nitrogen for 3 months. After thawing, the isolation, morphology, proliferation, cell cycle, colony-forming-unit ability, stemness-related marker expression, apoptosis, and multi-lineage differentiation potential of DFCs-CF were tested compared with DFCs-CC. DFCs-CF expressed mesenchymal stem cells marker, proliferated well, showed similar levels of mRNA for stemness- and apoptosis-related genes and exhibited the capacity of multi-lineage differentiation similar to those of DFCs-CC. These results imply that cryopreservation of dental follicle fragments is an effective banking method for isolation of dental follicle cells.",
        "keywords": [
            "Cryopreservation",
            "Dental follicles",
            "Mesenchymal stem cells"
        ],
        "authors": [
            {
                "name": "Hefeng Yang",
                "org": "Department of Dental Research, The Affiliated Stomatological Hospital of Kunming Medical University, Kunming, Yunnan 650500, PR China; National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Jie Li",
                "org": "Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, College of Stomatology, Chongqing Medical University, Chongqing, 401147, PR China."
            },
            {
                "name": "Jingjing Sun",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Weihua Guo",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Hui Li",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Jinlong Chen",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Yu Hu",
                "org": "Department of Orthodontics, The Affiliated Stomatological Hospital of Kunming Medical University, Kunming, Yunnan 650031, PR China."
            },
            {
                "name": "Weidong Tian",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Song Li",
                "org": "Department of Dental Research, The Affiliated Stomatological Hospital of Kunming Medical University, Kunming, Yunnan 650500, PR China."
            }
        ],
        "venue": "Cryobiology",
        "year": 2017
    },
    "w34UEUbD": {
        "id": "w34UEUbD",
        "title": "Increased survival of free fat grafts with adipose-derived stem cells and platelet-rich plasma in nude mice",
        "abstract": "Objecitve: To investigate the impact of combined adipose-derived stem cells (ASCs) and plateletrich plasma (PRP) on the survival of transplanted fat. Methods: The ASCs were isolated and cultured from fat tissues by enzyme digestion; and the PRP was prepared by two-step ultracentrifugation. The grafts of fat granules were divided into test groups (ASCs + PRP + fat granules, PRP + fat granules, ASCs + fat granules) and control groups (PBS+fat granules). The grafts were injected into the left and right dorsal subcutaneous areas of nude mice. General observations, volume measurements and microscope examinations were conducted 10 d, 30 d, 60 d and 90 d after transplantation. Results: The grafts of the mice in the ASCs + PRP group showed soft structure, with light yellow color and closer to normal adipose tissue compared with those in other groups. Greater survival volumes (P<0. 05) and better histology were also observed in the grafts of the mice in the ASCs + PRP group. Conclusion: The fat grafts consisting of PRP and ASCs constitute an ideal transplant strategy, which could provide a valuable and needed tool in plastic and reconstructive surgery.",
        "keywords": [
            "Adipose-derived stem cells",
            "Fat transfer",
            "Platelet-rich plasma"
        ],
        "authors": [
            {
                "name": "Kun Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Feng Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "GUO Li-juan",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jie Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Ke Huang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "GUO Wei-hua",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2013
    },
    "MF8MjJic": {
        "id": "MF8MjJic",
        "title": "Molecular and cellular characterization during chondrogenic differentiation of adipose tissue-derived stromal cells in vitro and cartilage formation in vivo",
        "abstract": "",
        "keywords": [
            "cell death",
            "apoptosis",
            "cell growth",
            "cr",
            "cancer",
            "immunology",
            "differentiation"
        ],
        "authors": [
            {
                "name": "yunfeng lin",
                "org": ""
            },
            {
                "name": "en luo",
                "org": ""
            },
            {
                "name": "xizhe chen",
                "org": ""
            },
            {
                "name": "lei liu",
                "org": ""
            },
            {
                "name": "zhengbin yan",
                "org": ""
            },
            {
                "name": "zhiyong li",
                "org": ""
            },
            {
                "name": "wei tang",
                "org": ""
            },
            {
                "name": "xiaohui zheng",
                "org": ""
            },
            {
                "name": "weidong tian",
                "org": ""
            }
        ],
        "venue": "Cell Research",
        "year": 2008
    },
    "Wc1d9LQI": {
        "id": "Wc1d9LQI",
        "title": "Construction of tissue culture model in vitro and investigation of transforming growth factor promoting pulp fibroblast to differentiate into the odontoblast",
        "abstract": "Objective To construct the tissue culture model in vitro, and investigate the potential of dental pulp fibroblast differentiating into the odontohlast and the promoting role of transforming growth factor \u03b21 (TGF-\u03b21) on it. Methods Human pulps were cultured for 3, 7, 14 and 21 days on bone matrix gelatin (BMG) in DMEM cultural medium supplemented with TGF-\u03b21. The characteristics of matrix were studied through toluidine blue and Mallory stain. Meanwhile, the expression of dentin salivary protein (DSP) on the pulp cells was investigated with immunohistochemical staining. Results This experiment found that the pulp tissue in vitro were able to develop into more progressive stage, and some pulp fibroblast cells to differentiate into odontoblast-like cells. Toluidine blue and Mallory staining analysis revealed the localized deposition of mineralized bone-dentin matrix that was detected at the site of dental pulp cells. Immunohistochemical analysis proved that the DSP synthesized in these cells with the presence of TGF-\u03b21. Conclusion The results demonstrate that this culture condition can maintain the phenotype of human pulp tissue. The model of organ culture is suitable to study the development of pulp tissue in vitro. TGF-\u03b21 can promote the potential of pulp cell into odontoblast, which provides an academic basis for tooth repair and regeneration.",
        "keywords": [
            "Bone-dentin matrix",
            "Organ culture",
            "Pulp fibroblast",
            "Transforming growth factors"
        ],
        "authors": [
            {
                "name": "Xin Nie",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yan Jin",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jie Long",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Ling Wu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Jing",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "LIN Yun-feng",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2008
    },
    "v7y3JGdy": {
        "id": "v7y3JGdy",
        "title": "Experimental Study on the Development of Tissue-engineered Tooth Germ with Heterotopic Allotransplantation",
        "abstract": "Objective To compare the growth and development of tissue engineered tooth germ implanted into different tissues, and explore a suitable growing environment for the tissue engineered teeth in vivo. Methods SD rat/porcine tooth germ cells from postnatal 4 days were used as seeding cells, which combined various scaffolding biomaterials to construct the compound with tissue engineered teeth. The allografts were implanted into renal subcapsule, the mesenteries and subcutaneous tissues. Then, the implants were retrieved at special time points for histological analysis. Results Further developments were not observed in the graft implanted into mesenteries and subcutaneous tissues. Partial grafts were fallen off and lost from the subcutaneous tissues after implanted, and there were obvious lymphocyte infiltrations in the mesenteries. Moreover, the enamel and pulp-dentin complex were observed within the graft implanted in the subrenal capsule, which indicated there to be good condition. Conclusion The subrenal capsule can provide a promising implantation environment for the further growth of allogeneic tissue engineered tooth germ, and the subrenal capsule implantation can be used as a new alternative method for tissue-engineering tooth in vivo.",
        "keywords": [
            "Allograft",
            "Development",
            "Tissue-engineering",
            "Tooth germ"
        ],
        "authors": [
            {
                "name": "Xin Nie",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yan Jin",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jie Long",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Ling Wu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Jing",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yun-Feng Lin",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei-Dong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2008
    },
    "M2G5irz8": {
        "id": "M2G5irz8",
        "title": "Application of modified retromandibular approach indirectly from the anterior edge of the parotid gland in the surgical treatment of condylar fracture.",
        "abstract": "To introduce a new surgical approach for open reduction and internal fixation of condylar fracture.In this study, 36 patients with condylar fractures (51 sides) and those of the mandibular ramus and coronoid process were treated using a modified retromandibular approach indirectly from the anterior edge of the parotid gland. The degree and type of mouth opening, occlusal relationship, facial nerve function, and other complications in the patients were assessed and evaluated.During the follow-up conducted over 12 to 24 months, x-ray examinations revealed good fracture healing. The occlusal relationship and degree and type of mouth opening improved significantly over those before operation. During the final follow-up at 24 months, no case of ankylosis and/or salivary fistula was observed. Major complications at 1 week postoperation included temporary injury to the facial nerve branches in 4 cases; this condition improved after 1 to 3 months.Open reduction and internal fixation of condylar fracture by using the modified retromandibular approach indirectly from the anterior edge of the parotid gland has many advantages. Compared with the traditional surgical incision, this method is simple and short, and the completely exposed operative field facilitates reduction and fixation. Compared with transparotid approaches, it substantially reduces the risk to the facial nerve. At the same time, this method is not only suitable for the surgical treatment of condylar fractures but also for those of the mandibular ramus and coronoid process.",
        "keywords": [],
        "authors": [
            {
                "name": "Wei Tang",
                "org": "Associate Professor, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, P.R. China"
            },
            {
                "name": "Chao Gao",
                "org": "Assistant Professor, Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, P.R. China"
            },
            {
                "name": "Jie Long",
                "org": "Associate Professor, Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, P.R. China"
            },
            {
                "name": "Yunfeng Lin",
                "org": "Assistant Professor, Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, P.R. China"
            },
            {
                "name": "Hang Wang",
                "org": "Associate Professor, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, P.R. China"
            },
            {
                "name": "Lei Liu",
                "org": "Associate Professor, Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, P.R. China"
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons",
        "year": 2009
    },
    "HjI4GBl9": {
        "id": "HjI4GBl9",
        "title": "Three-dimensional finite element analysis of the stress distribution of condylar cartilage during mandibular distraction osteogenesis in goats",
        "abstract": "Aim: To analyze the stress distribution of the condylar cartilage during mandibular distraction osteogenesis in goats. Methods: The experiment was performed at the Key lab of Biomechanics, Sichuan University and Animal Operation Center, West China Stomatology Hospital ,Sichuan University from January to December 2005. Corticotomy was performed in right side mandible of 1 goat, distraction force exerting for 4 times daily, distraction frequency was 0.2 mm/ 6 hours, distraction rate was 0.8 mm/day, distraction period was 12 days, and then entering the consolidation period. The animal was sacrificed at 4th week after distraction, CT scaning was done to the craniofacial bone with SIMENS SOMATOM 16 spiral CT, the 3D finite element model was established by the Mimics software, and then the stress distribution of the condylar cartilage was analyzed by Patran software. Results: (1) The value of Von Mises stress on the surface of the condylar cartilage of the distraction side was higher than that of the other side [Von Mises stress of distraction side / Von Mises stress of the other side: 14.6/0.92 in anterior-internal slope of condylar cartilage, 2.3/0.17 in anterior-middle slope of condylar cartilage, 4.5/ 0.9 in posterior-external slope of condylar cartilage, 5.7/0.6 in interal 1/3 of transverse ridge of condylar cartilage, 2.6/0.8 in middle 1/3 of transverse ridge of condylar cartilage, 1.8/0.11 in external 1/3 of transverse ridge of condylar cartilage, 1.7/1.1 in posterior-internal slope of condylar cartilage, 0.9/0.2 in posterio-middle slope of condylar cartilage, 1.4/0.3 in posterior-external slope of condylar cartilage]; (2)The anterior slope of condyle was the most pressed area, but the transverse ridge area and posterior slope area were most pulled area; (3)In the observation of sagital direction, it showed that mean value of Von Mises stress on the surface of anterior slope was the maximum, followed by transverse ridge area and that was the minimal at posterior slope; In the observation of coronal direction, the mean value of Von Mises stress was larger in the internal area than the middle and external area. Conclusion: The distraction force will lead to some stress distribution on the surface of condylar cartilage during distraction osteogenesis, and the stress would make some changes in the TMJ (temporomandibular joint).",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Jie Long",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Fan Yu-bo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Tian Wei-dong",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Ling Wu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Zheng Xiao-hui",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Chinese Journal of Clinical Rehabilitation",
        "year": 2006
    },
    "Hp83sNrF": {
        "id": "Hp83sNrF",
        "title": "Increased survival of human free fat grafts with varying densities of human adipose-derived stem cells and platelet-rich plasma.",
        "abstract": "The high absorption rate of transplanted fat has limited the application of autogenous fat grafts in the clinical setting. Therefore, this study aimed to evaluate the effects of platelet-rich plasma (PRP) and adipose-derived stem cells (ASCs) on fat regeneration by investigating the impact of PRP and conditioned medium on the biological characteristics of ASCs. Fat grafts were prepared with ASCs at densities of 10(7) /ml, 10(6) /ml, 10(5) /ml, 10(4) /ml and 0/ml with and without PRP and injected subcutaneously into nude mice. Liquid overflow method, haematoxylin and eosin staining, and immunohistochemical analyses were used to examine the fat grafts. The residual fat volume of the 10(5) /ml ASC\u2009+\u2009PRP group was significantly higher than that of other treatment conditions after 90\u2009days. Furthermore, histological examination revealed that in 10(5) /ml ASCs-treated grafts normal adipocyte area and capillary formation were increased dramatically compared with other treatment conditions. It is concluded that fat grafts consisting of PRP and 10(5) /ml ASCs constitute an ideal transplant strategy, which may result in decreased absorption and accelerated fat regeneration. This simple and reliable method could provide a valuable and needed tool in plastic and reconstructive surgery. Copyright \u00a9 2014 John Wiley & Sons, Ltd.",
        "keywords": [
            "adipose-derived stem cells",
            "angiogenesis",
            "fat regeneration",
            "fat transfer",
            "graft survival",
            "platelet-rich plasma"
        ],
        "authors": [
            {
                "name": "Kun Li",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, China; Department of Oral and Maxillofacial Surgery, School of stomatology, Central South University, Changsha, China."
            },
            {
                "name": "Feng Li",
                "org": ""
            },
            {
                "name": "Jie Li",
                "org": ""
            },
            {
                "name": "Hang Wang",
                "org": ""
            },
            {
                "name": "Xiaohui Zheng",
                "org": ""
            },
            {
                "name": "Jie Long",
                "org": ""
            },
            {
                "name": "Weihua Guo",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Journal of tissue engineering and regenerative medicine",
        "year": 2014
    },
    "PJ4hUlSt": {
        "id": "PJ4hUlSt",
        "title": "Tooth root regeneration using dental follicle cell sheets in combination with a dentin matrix - based scaffold.",
        "abstract": "Stem cell mediated tissue engineering has been acknowledged as a prospective strategy for repairing and replacing damaged and lost tissues. However, the low survival rate of implanted stem cells proves to be a major challenge in the management of transplantation failures. While previous studies have indicated the effectiveness of tissue engineered cell sheets in improving the survival rate of implanted cells, we have recently demonstrated the use of treated dentin matrix (TDM) as a biological scaffold and dental follicle cells (DFCs) as the seeding cells for dentinogenesis and tooth root construction. This study proposes a strategy utilizing TDM with human dental follicle cell sheets (DFCSs) for root regeneration. The biological characteristics and changes of human DFCSs under the effect of TDM were studied with scanning electron microscopy, transmission electron microscopy, immunofluorescence microscopy, immunohistochemistry and quantitative real-time PCR. DFCSs combined with TDM were implanted subcutaneously into the dorsum of mice. Histological examination of the harvested grafts revealed a whirlpool-like alignment of the DFCs in multiple layers that were positive for COLI, integrin\u03b21, fibronectin and alkaline phosphatase (ALP), suggestive of the formation of a rich extracellular matrix. DFCSs, under the effect of TDM, highly expressed DMP-1 and bone sialoprotein (BSP), indicating their potential for odontogenesis and osteogenesis. Importantly, in vivo, TDM could induce and support DFCSs to develop new dentin-pulp like tissues and cementum-periodontal complexes that were positive for markers such as DSP, nestin and VIII factors, COLI and cementum attachment protein (CAP), implying successful root regeneration. Therefore, DFCSs combined with TDM may prove to be a better strategy for the construction of tooth root, and is a prospective approach that could be utilized for the treatment of root or tooth defect or loss in future.",
        "keywords": [
            "dental follicle cell",
            "tooth root",
            "tooth regeneration",
            "cell sheet technology",
            "treated dentin matrix"
        ],
        "authors": [
            {
                "name": "Bo Yang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Gang Chen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jie Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Qing Zou",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Dan Xie",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yali Chen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Hang Wang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xiaohui Zheng",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jie Long",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weihua Guo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Biomaterials",
        "year": 2012
    },
    "OGaD6Lpq": {
        "id": "OGaD6Lpq",
        "title": "A new surgical approach to treat medial or low condylar fractures: the minor parotid anterior approach.",
        "abstract": "A new surgical approach, denoted as the minor parotid anterior approach, was designed to treat medial or low mandibular condylar fractures.Sixty patients (72 sides) with medial or low condylar fractures were treated surgically. Thirty-six patients (42 sides) were treated with the minor parotid anterior approach, and 24 patients (30 sides) were treated with a retromandibular approach. Data on the surgical procedures and complications were recorded. The follow-up period was 3 to 12 months.Four patients suffered facial nerve injury in the group treated with the retromandibular approach. No cases of facial nerve injury occurred in the minor parotid anterior approach group.The minor parotid anterior approach avoided facial nerve injury, resulted in less visible facial scarring, and required less manipulation time. Therefore, the minor parotid anterior approach is worth application in the clinical setting.",
        "keywords": [],
        "authors": [
            {
                "name": "Jia Hou",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lin Chen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Tingting Wang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Jing",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jie Long",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Oral surgery, oral medicine, oral pathology and oral radiology",
        "year": 2014
    },
    "nPlDPOPW": {
        "id": "nPlDPOPW",
        "title": "Comparison of P75 NTR-positive and -negative etcomesenchymal stem cell odontogenic differentiation through epithelial-mesenchymal interaction.",
        "abstract": "The aim of this study was to investigate differences of odonto-differentiation between P75 -neurotrophin receptor (P75 -NTR)-positive ectomesenchymal stem cells (P75+EMSCs) and P75 -NTR-negative ectomesenchymal stem cells (P75-EMSCs), and their underlying mechanisms.Primary cranial neural crest-derived cells (CNC) were isolated from the first branchial arches, and P75+EMSCs and P75-EMSCs were sorted by fluorescence-activated cell sorting. Differentiation of P75+EMSCs or P75-EMSCs into odontoblast-like cells was induced by dental epithelial cells in vitro or in vivo. Differential gene expression profiles between P75+EMSCs and P75-EMSCs were analysed by microarray assay. Smad4-specific small interfering RNA and activator kartogenin were used to treat the cells, to evaluate effects of Smad4 in odonto-differentiation of P75+EMSCs or P75-EMSCs.Under induction of dental epithelium conditioned medium, P75+EMSCs had more mineralized node formation and higher expression of Dmp1 and Dspp compared to P75-EMSCs. In our in vivo study, graft of P75+EMSCs recombination with dental epithelium showed higher expression of DMP1 and DSP. Knock-down of Smad4 in P75+EMSCs significantly downregulated expression of DMP1 and DSP, while activation of Smad4 in P75-EMSCs by the activator kartogenin, significantly increased DSP and DMP1 expression.P75+EMSCs showed more odonto-differentiation potential than P75-EMSCs both in vivo and in vitro. Smad4 played a critical role in determination of odonto-differentiation potential of CNC-derived EMSCs.",
        "keywords": "",
        "authors": [
            {
                "name": "Yongjun Xing",
                "org": "Department of Stomatology, Daping Hospital &amp; Research Institute of Surgery, Third Military Medical University, Chongqing, 400038, China."
            },
            {
                "name": "Xin Nie",
                "org": "Department of Stomatology, Daping Hospital &amp; Research Institute of Surgery, Third Military Medical University, Chongqing, 400038, China."
            },
            {
                "name": "Guoqing Chen",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China."
            },
            {
                "name": "Xiujie Wen",
                "org": "Department of Stomatology, Daping Hospital &amp; Research Institute of Surgery, Third Military Medical University, Chongqing, 400038, China."
            },
            {
                "name": "Gang Li",
                "org": "Department of Stomatology, Daping Hospital &amp; Research Institute of Surgery, Third Military Medical University, Chongqing, 400038, China."
            },
            {
                "name": "Xia Zhou",
                "org": "Department of Stomatology, Daping Hospital &amp; Research Institute of Surgery, Third Military Medical University, Chongqing, 400038, China."
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China."
            },
            {
                "name": "Luchuan Liu",
                "org": "Department of Stomatology, Daping Hospital &amp; Research Institute of Surgery, Third Military Medical University, Chongqing, 400038, China."
            }
        ],
        "venue": "Cell proliferation",
        "year": 2016
    },
    "I0M7dz2f": {
        "id": "I0M7dz2f",
        "title": "Metabolic reprogramming by HIF-1 activation enhances survivability of human adipose-derived stem cells in ischaemic microenvironments.",
        "abstract": "Poor cell survival severely limits the beneficial effect of adipose-derived stem cell (ADSC)-based therapy for disease treatment and tissue regeneration, which might be caused by the attenuated level of hypoxia-inducible factor-1 (HIF-1) in these cells after having been cultured in 21% ambient oxygen in vitro for weeks. In this study, we explored the role of pre-incubation in dimethyloxalylglycine (DMOG, HIF-1 activator) in the survivability of human ADSCs in a simulated ischaemic microenvironment in vitro and in vivo. The underlying mechanism and angiogenesis were also studied.Survivability of ADSCs was determined in a simulated ischaemic model in vitro and a nude mouse model in vivo. Cell metabolism and angiogenesis were investigated by tube formation assay, flow cytometry, fluorescence staining and real-time polymerase chain reaction (RT-PCR) after DMOG treatment.The results of the experimental groups showed significant enhancement of ADSC survivability in a simulated ischaemic microenvironment in vitro and transplanted model in vivo. Study of the underlying mechanisms suggested that the improved cell survival was regulated by HIF-1-induced metabolic reprogramming including decreased reactive oxygen species, increased intracellular pH, enhanced glucose uptake and increased glycogen synthesis. Tube formation assay revealed higher angiogenic ability in the DMOG-treated group than that in control group.The promotion of HIF-1 level in ADSCs induced by DMOG preconditioning suggests a potential strategy for improving the outcome of cell therapy due to increased survival and angiogenic ability.",
        "keywords": "",
        "authors": [
            {
                "name": "Chang Chen",
                "org": "State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Qi Tang",
                "org": "State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Yan Zhang",
                "org": "State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Minjia Dai",
                "org": "State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Yichen Jiang",
                "org": "State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Hang Wang",
                "org": "State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Mei Yu",
                "org": "State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Wei Jing",
                "org": "State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            }
        ],
        "venue": "Cell proliferation",
        "year": 2017
    },
    "83nJL9Z4": {
        "id": "83nJL9Z4",
        "title": "Research and practice of the network-based teaching system for developing medical students' clinical thinking",
        "abstract": "By making oral and maxillofacial surgery a trial,our hospital established a digital teaching platform that is compatible with the hospital information system and used it in undergraduate teaching.The results show that the network-based teaching system meets the requirements of teaching and is conducive to developing medical students' clinical thinking.",
        "keywords": [
            "network-based",
            "clinical thinking",
            "medicine"
        ],
        "authors": [
            {
                "name": "Wang Hang",
                "org": " Department of Oral and Maxillofacial Surgery, West China College of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Liang Chengwen",
                "org": " Department of Oral and Maxillofacial Surgery, West China College of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Ji Baohui",
                "org": " Department of Oral and Maxillofacial Surgery, West China College of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Li Rui",
                "org": " Department of Oral and Maxillofacial Surgery, West China College of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Tian Weidong",
                "org": " Department of Oral and Maxillofacial Surgery, West China College of Stomatology,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "China Medical Education Technology",
        "year": 2011
    },
    "eog8JxHg": {
        "id": "eog8JxHg",
        "title": "Identification of three novel mutations of IRF6 in Chinese families with Van der Woude syndrome",
        "abstract": "Objective: To identify mutations of interferon regulatory factor 6 (IRF6) gene in Van der Woude syndrome (VWS) patients in China. Methods: Three Chinese VWS families were screened to IRF6 gene mutation via PCR and sequence techniques. After amplification of exons 1-8 and their flanking splice junctions and part of exon 9 of the IRF6 gene by polymerase chain reaction, mutations were detected by direct sequencing. Results: Three novel mutations, one in each family, were identified in all the affected members in the three families. There were one missense mutation 1214(T\u2192C) in exon 9, two nonsense mutations 981(T\u2192A) in exon 7 and 1234(C\u2192T) in exon 9. All affected members of the three families were heterozygous for their respective mutation. Conclusion: Mutations in IRF6 gene were found in all VWS patients. This observation supports the hypothesis that IRF6 is the gene responsible for VWS across different populations.",
        "keywords": [
            "Cleft lip and or palate",
            "Gene mutation",
            "IRF6 gene",
            "Van der Woude syndrome"
        ],
        "authors": [
            {
                "name": "Xin-ya Du",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei-dong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xiaoy\u00fc Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xiao-hui Zheng",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics",
        "year": 2006
    },
    "sOrxugSu": {
        "id": "sOrxugSu",
        "title": "Clinical evaluation of computer-assisted surgical technique in the treatment of comminuted mandibular fractures",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "peng li",
                "org": ""
            },
            {
                "name": "wei tang",
                "org": ""
            },
            {
                "name": "chuhang liao",
                "org": ""
            },
            {
                "name": "peiyong tan",
                "org": ""
            },
            {
                "name": "jingkui zhang",
                "org": ""
            },
            {
                "name": "weidong tian",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2015
    },
    "IjIxpmZJ": {
        "id": "IjIxpmZJ",
        "title": "Clinical study on reconstruction of hemifacial atrophy with serratus anterior free-muscle flap]",
        "abstract": "To study the method of treating hemifacial atrophy with free serratus muscle flap.Three patients diagnosed as having serious hemifacial atrophy was treated with free serratus muscle flap. The root of the flap was thoracodorsal artery and thoracodorsal vein, which was anastomosed with superficial temporal artery and vein, facial artery and vein, lingual artery and vein, and so on. During the operation, long thoracic nerve was dissected and anastomosed with facial nerve. The sizes of the flaps were 12 cm x 8 cm - 16 cm x 12 cm.All free-muscle flaps healed well after the transplant. The face and buccal area looked chubby and rounded. There were no obvious protuberance and discontentment on the buccal area. The shoulders of all patients moved well. The facial contour of the patients recovered well during the follow-up period (1-3 years).The method has a good result. The long-term effect needs further study.",
        "keywords": [
            "serratus anterior free-muscle flap hemifacial atrophy correct and cure"
        ],
        "authors": [
            {
                "name": "Weidong Tian",
                "org": "China College of Stomatology, Sichuan University, Chengdu Sichuan, 610041, PR China. drtwd@sina.com"
            },
            {
                "name": "Dong Wang",
                "org": ""
            },
            {
                "name": "Leu Liu",
                "org": ""
            },
            {
                "name": "Fuguo Huang",
                "org": ""
            },
            {
                "name": "Qian Xie",
                "org": ""
            },
            {
                "name": "Zhengbin Yan",
                "org": ""
            },
            {
                "name": "Yisong Li",
                "org": ""
            },
            {
                "name": "Shengwei Li",
                "org": ""
            }
        ],
        "venue": "Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery",
        "year": 2005
    },
    "Au15K8mY": {
        "id": "Au15K8mY",
        "title": "Effects on the new bone formation by different distraction rate during mandibular distraction osteogenesis in goats",
        "abstract": "Objective:To investigate the effects on the new bone formation by different distraction rate during mandibular distraction osteogenesis in goats.Methods: The right side mandibles of twelve goats were distracted after corticortomy,and all the animals were divided into 3 groups randomly, the first group were distracted with 0.8 mm/day, the second group were distracted with 1.6 mm/day, the third group were distracted with 2.0 mm/day, and the left side mandible of 4 goats from above groups were selected randomly as the control group.Then the new generation bone after distraction with different rate were studied by bone density examination and three point bending test.Results: The bone density value of the 0.8 mm/day group were higher than the other two experimental groups; the results of three point bending test showed that the biomechanical strength of the new generation bone in 0.8 mm/day group was higher than the other two experimental groups.Conclusion:0.8 mm/day may be the best distraction rate in mandibular distraction osteogenesis.",
        "keywords": [
            "Mandible",
            "Distraction rate",
            "Goat",
            "Distraction osteogenesis"
        ],
        "authors": [
            {
                "name": "Long Jie",
                "org": ",et al. The Key Laboratory of Biomechanics, Sichuan University, Chengdu ,China"
            },
            {
                "name": "Fan Yubo",
                "org": ",et al. The Key Laboratory of Biomechanics, Sichuan University, Chengdu ,China"
            },
            {
                "name": "Tian Weidong",
                "org": ",et al. The Key Laboratory of Biomechanics, Sichuan University, Chengdu ,China"
            }
        ],
        "venue": "Journal of Practical Stomatology",
        "year": 2007
    },
    "jeIZIzwL": {
        "id": "jeIZIzwL",
        "title": "Biomechanical analysis and comparison of 12 dental implant systems using 3D finite element study.",
        "abstract": "Finite element analysis plays an important role in dental implant design. The objective of this study was to show the effect of the overall geometry of dental implants on their biomechanics after implantation. In this study, 12 dental implants, with the same length, diameter and screw design, were simulated from different implant systems. Numerical model of right mandibular incisor bone segment was generated from CT data. The von-Mises stress distributions and the total deformation distributions under vertical/lateral load were compared for each implant by scores ranking method. The implants with cylindrical shapes had highest scores. Results indicated that cylindrical shape represented better geometry over taper implant. This study is helpful in choosing the optimal dental implant for clinical application and also contributes to individual implant design. Our study could also provide reference for choice and modification of dental implant in any other insertion sites and bone qualities.",
        "keywords": [
            "dental implant",
            "finite element",
            "implant shape"
        ],
        "authors": [
            {
                "name": "Rui Liang",
                "org": "a State Key Laboratory of Oral Diseases , Sichuan University , Chengdu , P.R. China."
            },
            {
                "name": "Weihua Guo",
                "org": ""
            },
            {
                "name": "Xiangchen Qiao",
                "org": ""
            },
            {
                "name": "Hailin Wen",
                "org": ""
            },
            {
                "name": "Mei Yu",
                "org": ""
            },
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            },
            {
                "name": "Yongtao Wei",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Computer methods in biomechanics and biomedical engineering",
        "year": 2015
    },
    "rxga7po9": {
        "id": "rxga7po9",
        "title": "Induced differentiation of human dental papilla mesenchymal cells into odontoblasts",
        "abstract": "AIM: To investigate the differentiation mechanism of human dental papilla mesenchymal cells toward odontoblast lineage. METHODS: The experiment was performed at the Key Laboratory of Oral Biomedical Engineering Ministry of Education of Sichuan University from April 2004 to March 2005. Human dental papilla mesenchymal cells were isolated from human 3 to 4 month old embryos obtained by spontaneous abortion (West China Second Hospital of Sichuan University, informed consent from the pregnant woman, and permission from Hospital Ethics Committee) and cultured in DMEM/F12 culture media without leukemia inhibitory factor. Cells induced with 10 \u03bcg/L insulin-like growth factor \u2160 (IGF-\u2160, Sigma) to differentiate toward odontoblast served as IGF-\u2160group; induced with 100 \u03bcg/L basic fibroblast growth factor (bFGF, Sigma) as bFGF group; with IGF-\u2160and bFGF together as the integrated group, and cells without any medicine as the blank control group. The morphological and functional changes of cells were examined by inverted microscope, immunocytochemistry and RT-PCR. RESULTS: \u2460After 7 days, the cultured cells induced with IGF-\u2160were polarized with long processes, and presented odontoblast-like cells, and the alkalinephosphatase activity of cells was remarkably increased; The cells induced with mixed IGF-\u2160and bFGF exhibited with longer processes and higher alkaline phosphatase activity compared with IGF-\u2160group. There was no obvious changes in cultured cells between IGF-\u2160group and control group. \u2461Immunohistological assay suggested that the immunocytochemistry staining of dentin sialophosphoprotein (DSPP) in kytoplasm was positive in the IGF-\u2160and integrated groups. \u2462The specific segment of 599 bp was obtained in integrated group and IGF-\u2160 group after RT-PCR, indicating the cells of these two groups expressed hDSPP mRNA by RT-PCR. No expression was found in the other groups. CONCLSUION: IGF-\u2160can stimulate human dental papilla mesenchymal cells to differentiate toward odontoblast-like cells. bFGF displays a synergistic inductive effect.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Jia M. Xie",
                "org": "Taizhou People's Hospital(Taizhou People's Hospital),,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Journal of Clinical Rehabilitative Tissue Engineering Research",
        "year": 2007
    },
    "YF3LldRH": {
        "id": "YF3LldRH",
        "title": "Mandibular distraction osteogenesis: an experimental study in goats]",
        "abstract": "This experiment was designed to develop an experimental model of mandibular distraction osteogenesis in goats for determining the principle and the process of distraction osteogenesis.Eight 3-month-old, healthy domestic goats were randomly divided into four groups (n = 2 per group). The animals from each group were killed at 1, 2, 4, and 6 weeks after bone distraction, respectively. The sections of newly formed bone were obtained and evaluated with histologic and radiographic study. We also assessed the newly formed bone with bone density examination.The specimens of right mandible increased averagely 10 mm after distraction. The Newly formed bone was demonstrated histologically. The X-ray examination and bone density measurements showed that the bone density increased with the time of fixation.Goat is a proper experimental animal for modeling mandibular distraction osteogenesis, and in this regal, it is important to keep the direction of distracter force in conformity with the direction of the expected distraction osteogenesis for avoiding the side force and thus ensuring successful distraction and good quality of newly formed bone.",
        "keywords": [
            "mandible    distraction osteogenesis    bone density"
        ],
        "authors": [
            {
                "name": "Xiao-hui Zheng",
                "org": "Department of Oral and Maxvllofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Wei-dong Tian",
                "org": ""
            },
            {
                "name": "Jie Long",
                "org": ""
            },
            {
                "name": "Wei Jing",
                "org": ""
            },
            {
                "name": "Sheng-wei Li",
                "org": ""
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2005
    },
    "clDe71zm": {
        "id": "clDe71zm",
        "title": "Adipogenic and osteogenic differentiation of Lin-CD271 +Sca-1+ adipose-derived stem cells",
        "abstract": "Adipose-derived stem cells (ASCs) have been defined as cells that undergo sustained in vitro growth and have multilineage differentiation potential. However, the identity and purification of ASCs has proved elusive due to the lack of specific markers and poor understanding of their physiological roles. Here, we prospectively isolated and identified a restricted homogeneous subpopulation of ASCs (Lin-CD271+Sca-1+) from mouse adipose tissues on the basis of cell-surface markers. Individual ASCs generated colony-forming unit-fibroblast at a high frequency and could differentiate into adipocytes, osteoblasts, and chondrocytes in vitro. Expansion of ASCs in a large quantity was feasible in medium supplemented with fibroblast growth factor-2 and leukemia inhibitory factor, without loss of adipogenic and osteogenic differentiation capacity. Moreover, we found that the transplanted ASCs can differentiate into adipocytes in adipogenic microenvironment in vivo and osteoblasts in osteogenic microenvironment in vivo. Thus we proved that Lin, CD271, and Sca-1 could be used as the specific markers to purify ASCs from adipose tissue. The method we established to identify ASCs as defined in vivo entities will help develop ASCs transplantation as a new therapeutic strategy for bone regeneration and adipose tissue regeneration in clinic. \u00a9 2013 Springer Science+Business Media New York.",
        "keywords": [
            "Adipose-derived stem cells",
            "Multilineage differentiation",
            "Regeneration",
            "Self-renew"
        ],
        "authors": [
            {
                "name": "Jingang Xiao",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xiaojuan Yang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Jing",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weihua Guo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Qince Sun",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yunfeng Lin",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wentong Meng",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Molecular and Cellular Biochemistry",
        "year": 2013
    },
    "5v5SpOHh": {
        "id": "5v5SpOHh",
        "title": "A study on myogenic differentiation of human adipose tissue-derived stromal cells]",
        "abstract": "To isolate human adipose tissue-derived stromal cells and study the potential of osteogenic differentiation after inductive culture.Liposuction human adipose tissues were minced and digested with collagenase type I. The obtained stromal cells were plated in BGJb medium as primary culture for ten days. The second passage cells were harvested and plated in DMEM/F12 medium supplemented with 10% FBS, 5% horse serum and 50 micromol/L hydrocortisone for myogenic induction culture. The cell-anchored slips were removed and fixed in 4% formaldehydam polymerisatum. Toluidine blue, Mallory's phosphotungstic hematoxylin staining and monoclonal antibody to human skeletal muscle myosin heavy chain immunocytochemical methods were used to assay the differentiation of cells.It was observed that the size and shape of induced cells were much different from those of non-induced cells. Toluidine blue, Mallory's phosphotungstic hematoxylin staining demonstrated there were many basophilic striations within cytoplasm and multinucleated myotubes were formed. Immunocytochemical stain indicated that characterastic skeletal myosin heavy chain was positive in myogenic induced cells.It seems that human adipose tissue represents an abundant reservoir of adult stem cells that have multi-germline potential to differentiate into myoblasts. Adipose tissue derived stromal cells will be another alternative source for cell-based tissue engineering in skeletal muscle reconstruction.",
        "keywords": [],
        "authors": [
            {
                "name": "Xi-ping Chen",
                "org": "VIP Clinic, The First Affiliated Hospital of Kunming Medical College, Kunming 650031, China."
            },
            {
                "name": "Xi-zhe Chen",
                "org": ""
            },
            {
                "name": "Yun-feng Lin",
                "org": ""
            },
            {
                "name": "Wei-dong Tian",
                "org": ""
            },
            {
                "name": "You-chao Tang",
                "org": ""
            },
            {
                "name": "Sheng-wei Li",
                "org": ""
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2004
    },
    "be3FdU4g": {
        "id": "be3FdU4g",
        "title": "An experimental study on circadian rhythm of the proliferative index of mandibular osteoblast in goats]",
        "abstract": "The aim of this study was to investigate the circadian rhythm of the proliferative index of mandibular osteoblasts of goats in a normal situation.Twenty four healthy goats were selected and randomly divided into six groups. They were killed, and a piece of bone tissue with 2 cm x 2 cm x 0.5 cm was obtained from right mandibular mental foramen region at 0:00, 4:00, 8:00, 12:00, 16:00 and 20:00 time points, after they had been fed for one week. The primary cell culture method was used to cultivate osteoblasts from the bone. The method of anti-5-bromodeoxyuridine monoclonal antibody and the flow cytometric analysis were used to detect the proliferative index of the mandibular osteoblasts at different time. The data were analyzed using the method of single cosine rhythmometry.The proliferative indexes of the mandibular osteoblasts of goats were higher at the nighttime and lower in the daytime. The undulation of the proliferative indexes displayed a significant circadian rhythm (P < 0.01). The peak value was obtained at about 19:44, and the lowest value at about 7:44.The proliferative indexes of the mandibular osteoblasts of goats are not stable within 24 hours in a normal situation, but with significant circadian rhythm. There are different proliferative indexes at different time points.",
        "keywords": [],
        "authors": [
            {
                "name": "Xiaohui Zheng",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Jie Long",
                "org": ""
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2003
    },
    "3GcFLzwb": {
        "id": "3GcFLzwb",
        "title": "A clinical study on immediate implantation of particulate hydroxylapatite artificial bone after teeth extraction]",
        "abstract": "The aim of this study is to investigate the effect and complication of immediate implantation of particulate hydroxylapatite artificial bone after teeth extraction.Particulate hydroxylapatite artificial bone was implanted into 65 extraction sockets after teeth extraction. All patients were followed up until 3 months after the operation. They are examined with clinical examination and X-ray examination to observe the effect and complication of the implantation operation.The wound healed well in all cases without any complication. Compared to the alveolar ridge before teeth extraction, and the height of the alveolar ridge after teeth extraction didn't decrease.Implantation of particulate hydroxylapatite artificial bone after teeth extraction could maintain the height of the alveolar ridge and reduce the complication of teeth extraction. It would be helpful for the following prosthetic restoration. The immediate implantation of artificial bone is therefore needed further study.",
        "keywords": [],
        "authors": [
            {
                "name": "Lei Liu",
                "org": "College of Stomatology, West China University of Medical Sciences."
            },
            {
                "name": "Shengwei Li",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2002
    },
    "1cBGrhPS": {
        "id": "1cBGrhPS",
        "title": "Experimental study on cell adhesion characteristic between porous biphasic calcium phosphate nanocomposite and bone marrow mesenchymal stem cells in vitro]",
        "abstract": "To study the adhesion characteristic in vitro between porous biphasic calcium phosphate (BCP) nanocomposite and bone marrow mesenchymal stem cells (MSCs) that have been induced and proliferated.MSCs obtained from SD rat bone marrow were in vitro induced and proliferated. After their osteoblastic phenotype were demonstrated, MSCs were seeded onto prepared porous BCP nanocomposite (experiment group)and common porous hydroxyapatite (control group). Their adhesion situation was analyzed by scanning electron microscope. The initial optimal cell seeding density was investigated between new pattern porous BCP nanocomposite and MSCs by MTT automated colorimetric microassay method.The differentiation of MSCs to osteoblastic phenotype were demonstrated by the positive staining of mineralized node, alkaline phosphatase (ALP) and collagen type I, the most appropriate seeding density between them was 2 X 10(6)/ml. The maximal number which MSCs could adhere to porous BCP nanocomposite was 1.28 X 10(7)/cm3.MSCs can differentiate to osteoblastic phenotype. The MSCs were well adhered to porous BCP nanocomposite.",
        "keywords": [
            "tissue engineered bonemarrow mesenchymal stem cellsporous biphasic calcium phosphate scaffoldrat"
        ],
        "authors": [
            {
                "name": "Tao Wang",
                "org": ", et al. Key Laboratory of Oral Biomedical Engineering of Ministry of Education, Sichuan University, Chengdu Sichuan,,P. R. China"
            },
            {
                "name": "Weidong Tian",
                "org": ", et al. Key Laboratory of Oral Biomedical Engineering of Ministry of Education, Sichuan University, Chengdu Sichuan,,P. R. China"
            },
            {
                "name": "Xizhe Chen",
                "org": ", et al. Key Laboratory of Oral Biomedical Engineering of Ministry of Education, Sichuan University, Chengdu Sichuan,,P. R. China"
            }
        ],
        "venue": "Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery",
        "year": 2006
    },
    "An4vvSsm": {
        "id": "An4vvSsm",
        "title": "Expression of Nfic during root formation in first mandibular molar of rat.",
        "abstract": "The transcription factor Nfic is a key regulator during tooth development. Nfic deficient mice exhibit short and abnormal molar roots and severely deformed incisors. Dental epithelial cells, known as Hertwig's epithelial root sheath (HERS), participate in root formation. However, whether Nfic is involved in HERS-mesenchyme interaction remains unclear. In this study, the detail temporal and spatial expression pattern of Nfic during rat molar development was examined using immunohistochemistry and in situ hybridization. Nfic was detected in ameloblasts, dental follicle cells (DFCs) and dental papilla cells (DPCs), especially the DPCs close to dentin, from postnatal day 5 to day 16. Nfic expression in DPCs, DFCs and HERS cells was also examined by western blot and RT-PCR. Nfic was detected in DPCs and DFCs, but not in HERS cells. Co-culture experiment further indicated that Nfic mRNA expression in DPCs was elevated by the presence of HERS cells. Our results revealed that Nfic could be a marker gene for root odontoblasts differentiation initiation and its expression might be regulated through epithelial-mesenchymal interaction.",
        "keywords": [
            "Nfic",
            "Root formation",
            "Hertwig\u2019s epithelial root sheath",
            "Epithelial\u2013mesenchymal interaction"
        ],
        "authors": [
            {
                "name": "Xiang Chen",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Chengdu, 610041, Sichuan Province, People's Republic of China."
            },
            {
                "name": "Guoqing Chen",
                "org": "sichuan university"
            },
            {
                "name": "Lian Feng",
                "org": "sichuan university"
            },
            {
                "name": "Zongting Jiang",
                "org": "sichuan university"
            },
            {
                "name": "Weihua Guo",
                "org": "sichuan university"
            },
            {
                "name": "Mei Yu",
                "org": "sichuan university"
            },
            {
                "name": "Weidong Tian",
                "org": "sichuan university"
            }
        ],
        "venue": "Journal of molecular histology",
        "year": 2014
    },
    "SqAX7VCG": {
        "id": "SqAX7VCG",
        "title": "tBHQ Suppresses Osteoclastic Resorption in Xenogeneic-Treated Dentin Matrix-Based Scaffolds.",
        "abstract": "Extracellularmatrix (ECM)-based scaffolds are important for their potential therapeutic application. Treated dentin matrix (TDM), a kind of ECM, seeded with allogeneic dental follicle stem cells (TDM/aDFC) provides a suitable inductive microenvironment for tooth root regeneration. Considering the limited sources, xenogeneic TDM (xTDM) is a possible alternative to allogeneic TDM; however, xTDM-based scaffold presents severe osteolysis and resorption lacunae causing regenerated tooth root failure. Immune response-induced excessive osteoclastogenesis plays a critical role in xenogeneic scaffold osteolysis and resorption. The impact of antioxidant, tert-butylhydroquinone (tBHQ), on xTDM/aDFCs-induced osteoclastogenesis and osteoclastic resorption in vivo and in vitro are investigated. tBHQ upregulates heme oxygenase-1 release and downregulates high mobility group box 1 mRNA expression. mRNA expression of other osteoclast-related genes including nuclear factor-kappa Bp65, receptor activator of nuclear factor kappa-B, nuclear factor of activated T-cells cytoplasmic 1, cathepsin K, and integrin \u03b23, also decreases significantly. Furthermore, tBHQ-treated xTDM/aDFCs scaffolds implanted into rhesus macaques show reduced osteolysis and osteoclastic resorption by microcomputed tomography and tartrate-resistant acid phosphatase staining. tBHQ-induced suppression of xTDM/aDFC-induced osteoclastogenesis and osteoclastic resorption presents a new strategy for the regeneration of biological tooth root and could be applied to the regeneration of other complex tissues and organs.",
        "keywords": [
            "extracellular matrix (ECM)",
            "osteoclastic resorption",
            "tert-butylhydroquinone (tBHQ)",
            "treated dentin matrix (TDM)-based scaffolds"
        ],
        "authors": [
            {
                "name": "Jingjing Sun",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China."
            },
            {
                "name": "Jie Li",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China."
            },
            {
                "name": "Hui Li",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China."
            },
            {
                "name": "Hefeng Yang",
                "org": "Department of Dental Research, The Affiliated Stomatological Hospital of Kunming Medical University, Kunming, 650031, China."
            },
            {
                "name": "Jinlong Chen",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China."
            },
            {
                "name": "Bo Yang",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China."
            },
            {
                "name": "Fangjun Huo",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China."
            },
            {
                "name": "Weihua Guo",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China."
            },
            {
                "name": "Weidong Tian",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China."
            }
        ],
        "venue": "Advanced healthcare materials",
        "year": 2017
    },
    "1k6mLzfc": {
        "id": "1k6mLzfc",
        "title": "Comparative study of human dental follicle cell sheets and periodontal ligament cell sheets for periodontal tissue regeneration.",
        "abstract": "Periodontal ligament cell (PDLC) sheets have been shown to contribute to periodontal tissue regeneration. Dental follicle cells (DFCs), acknowledged as the precursor cells of PDLCs, have demonstrated stemness, embryonic features, heterogeneity, and pluripotency. Therefore, we hypothesized that DFC sheets might be more effective and suitable for periodontal tissue regeneration than PDLC sheets. In this study, we compared the biological characteristics of DFC sheets and PDLC sheets in vitro. To investigate the potential for periodontal tissue regeneration in vivo, complexes composed of two types of cell sheets combined with dentin matrix were implanted subcutaneously into nude mice for 6 weeks. Our results showed that, when forming cell sheets, DFCs secreted richer extracellular matrix than PDLCs. And compared to DFCs, DFC sheets expressed high levels of calcification-related genes, including alkaline phosphatase (alp), bone sialoprotein (bsp), osteopontin (opn), runt-related transcription factor (runx2), as well as the periodontal ligament-specific genes collagen III (col III) and periostin, while the gene expression of bsp, osteocalcin (ocn), and opn were greatly increased in PDLC sheets, when compared to PDLCs. col I expression did not change significantly. However, cementum protein 23 (cp-23) expression increased several fold in PDLC sheets compared to PDLCs but decreased in DFC sheets compared to DFCs. DFC and PDLC sheets were both positive for Collagen I (Col I), cementum attachment protein (CAP), ALP, BSP, OCN, and OPN protein expression, and Col I, ALP, BSP, and OPN expression were increased after cell sheets were formed. Furthermore, the levels of laminin and fibronectin were higher in DFCs and DFC sheets than that of PDLCs and PDLC sheets, respectively. In vivo, DFC and PDLC sheets could both regenerate periodontal tissue-like structures, but DFC sheets demonstrated stronger periodontal regeneration potential than PDLC sheets. Therefore, DFC sheets derived from discarded dental follicle tissue after tooth extraction may be more advantageous for clinical periodontal tissue regeneration in the future.",
        "keywords": [
            "cell sheets",
            "dental follicle cells (dfcs)",
            "periodontal ligament cell (pdlce)",
            "periodontal tissue regeneration"
        ],
        "authors": [
            {
                "name": "Shujuan Guo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weihua Guo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yi Ding",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jian Gong",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Qing Zou",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Dan Xie",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yali Chen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yafei Wu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Cell transplantation",
        "year": 2013
    },
    "2liTymHK": {
        "id": "2liTymHK",
        "title": "Corrosion resistant properties of different anodized microtopographies on titanium surfaces]",
        "abstract": "To investigate the corrosion resistant properties of titanium samples prepared by anodic oxidation with different surface morphologies.Pure titanium substrates were treated by anodic oxidation to obtain porous titanium films in micron, submicron, and micron-submicron scales. The surface morphologies, coating cross-sectional morphologies, crystalline structures, and surface roughness of these samples were characterized. Electrochemical technique was used to measure the corrosion potential (Ecorr), current density of corrosion (Icorr), and polarization resistance (Rp) of these samples in a simulated body fluid.Pure titanium could be modified to exhibit different surface morphologies by the anodic oxidation technique. The Tafel curve results showed that the technique can improve the corrosion resistance of pure titanium. Furthermore, the corrosion resistance varied with different surface morphologies. The submicron porous surface sample demonstrated the best corrosion resistance, with maximal Ecorr and Rp and minimal Icorr.Anodic oxidation technology can improve the corrosion resistance of pure titanium in a simulated body fluid. The submicron porous surface sample exhibited the best corrosion resistance because of its small surface area and thick barrier layer.",
        "keywords": "",
        "authors": [
            {
                "name": "Huo Fangjun",
                "org": ""
            },
            {
                "name": "Xie Li",
                "org": ""
            },
            {
                "name": "Tong Xingye",
                "org": ""
            },
            {
                "name": "Wang Yueting",
                "org": ""
            },
            {
                "name": "Guo Weihua",
                "org": ""
            },
            {
                "name": "Tian Weidong",
                "org": ""
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2015
    },
    "rSIcsQW3": {
        "id": "rSIcsQW3",
        "title": "A retrospective study of traumatic temporal hollowing and treatment with titanium mesh.",
        "abstract": "In this study, temporal hollowing was classified into primary and secondary traumatic temporal hollowing according to etiology. This was done to analyze the relationship between the nature of different fractures and temporal hollowing. The options for prophylaxis and treatment for temporal hollowing were explored. Data from 428 patients with zygomatic bone and arch fractures between 2004 and 2009 were analyzed retrospectively. The results showed that the incidences of primary and secondary traumatic temporal hollowing were 6.1% and 52.4%, respectively. Moreover, as the severity of fractures increased, the incidence of primary and secondary temporal hollowing increased. A follow-up study of titanium mesh implantation showed that titanium mesh reconstruction resulted in good cosmetic repair without serious complications. Thus, the internal fixation of primary fractures as well as titanium mesh implantation is recommended for patients with serious fractures to reduce the incidence of postoperative temporal hollowing and avoid secondary operations.",
        "keywords": [
            "coronal dissection",
            "temporal hollowing",
            "titanium mesh",
            "zygomatic fracture"
        ],
        "authors": [
            {
                "name": "Jun Guo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jie Long",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Hani Gong",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Shijun Duan",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Annals of plastic surgery",
        "year": 2012
    },
    "ByBKdoeb": {
        "id": "ByBKdoeb",
        "title": "MicroRNA-143 regulates adipogenesis by modulating the MAP2K5-ERK5 signaling.",
        "abstract": "A better understanding of the molecular mechanisms that regulate adipose tissue-derived stromal cell (ADSC) differentiation could provide new insight into some adipose-tissue-related disease. The differentiation of ADSCs into adipocytes is a complex physiological process that includes clonal expansion, growth arrest, and terminal differentiation. Here the role of microRNA-143 (miR-143) during ADSC adipogenic differentiation was systematically investigated. We found that miR-143 expression was transiently decreased after adipogenic induction while increased from day 3 and peaked on day 7 after induction. We show for the first time that the role of miR-143 is not consistent in the differentiation process. The regulatory role depends on the differentiation stage that miR-143 acts on. When miR-143 is overexpressed during the clonal expansion stage, the adipogenic differentiation of ADSCs is inhibited, whereas the overexpression of miR-143 during the growth arrest stage or terminal differentiation stage promotes differentiation. Further we firstly demonstrate that miR-143 plays the modulational role by directly repressing MAP2K5, a key member of the MAPKK family in the MAPK signaling pathway. These findings suggest that miR-143 plays an important role in adipose tissue formation, with special implications for some metabolic disease in which the amount and/or function of adipose tissue is altered.",
        "keywords": [],
        "authors": [
            {
                "name": "Lin Chen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jia Hou",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lanfeng Ye",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yuanwei Chen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Junhui Cui",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Cai Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Scientific reports",
        "year": 2014
    },
    "dgesqyLP": {
        "id": "dgesqyLP",
        "title": "TGF-\u03b21 and FGF2 stimulate the epithelial-mesenchymal transition of HERS cells through a MEK-dependent mechanism.",
        "abstract": "Hertwig's epithelial root sheath (HERS) cells participate in cementum formation through epithelial-mesenchymal transition (EMT). Previous studies have shown that transforming growth factor beta 1 (TGF-\u03b21) and fibroblast growth factor 2 (FGF2) are involved in inducing EMT. However, their involvement in HERS cell transition remains elusive. In this study, we confirmed that HERS cells underwent EMT during the formation of acellular cementum. We found that both TGF-\u03b21 and FGF2 stimulated the EMT of HERS cells. The TGF-\u03b21 regulated the differentiation of HERS cells into periodontal ligament fibroblast-like cells, and FGF2 directed the differentiation of HERS cells into cementoblast-like cells. Treatment with TGF-\u03b21 or FGF2 inhibitor could effectively suppress HERS cells differential transition. Combined stimulation with both TGF-\u03b21 and FGF-2 did not synergistically accelerate the EMT of HERS. Moreover, TGF-\u03b21/FGF2-mediated EMT of HERS cells was reversed by the MEK1/2 inhibitor U0126. These results suggest that TGF-\u03b21 and FGF2 induce the EMT of HERS through a MAPK/ERK-dependent signaling pathway. They also exert their different tendency of cellular differentiation during tooth root formation. This study further expands our knowledge of tooth root morphogenesis and provides more evidence for the use of alternative cell sources in clinical treatment of periodontal diseases.",
        "keywords": [],
        "authors": [
            {
                "name": "Jie Chen",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P.R. China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P.R. China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P.R. China."
            },
            {
                "name": "Guoqing Chen",
                "org": ""
            },
            {
                "name": "Zhiling Yan",
                "org": ""
            },
            {
                "name": "Yongwen Guo",
                "org": ""
            },
            {
                "name": "Mei Yu",
                "org": ""
            },
            {
                "name": "Lian Feng",
                "org": ""
            },
            {
                "name": "Zongting Jiang",
                "org": ""
            },
            {
                "name": "Weihua Guo",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Journal of cellular physiology",
        "year": 2014
    },
    "xDAiuvSp": {
        "id": "xDAiuvSp",
        "title": "Diagnosis and Therapy of Carotid Body Tumors",
        "abstract": "Objective: To summarize the experience in diagnosis and therapy of carotid body tumor,promote the rate of diagnosis and successful rate of operation and minimize intra and postoperative complications.Methods: A retrospective study was based on 30 patients with carotid body tumors diagnosed and treated between 1996 and 2005.Results: 30 patients underwent digital subtraction angiography(DSA),all of which were considered as carotid body tumors.B ultrasonography was performed in 14 cases,among which 12 cases were correctly diagnosed.Twenty cases underwent computed tomography,among which 16 cases were considered as carotid body tumors.Magnetic resonance imaging and magnetic resonance angiography were performed in 16 cases,among which 14 cases were considered as carotid body tumors.Twenty-two cases underwent temporary balloon occlusion(TBO),among which 8 cases were positive. All 30 cases received surgical operation with different kinds of procedures,all of which had no mortality and recurrence during the follow-up period,but long-lasting hemiplegia happened in 1 case.Conclusion: DSA examination is the best method to diagnose carotid body tumors.MRI/MRA and BUS are valuable to diagnose carotid body tumors.Surgery is the first choice to carotid body tumors.DSA and TBO examination can help to draw out and decide reasonable treatment method.Enough preoperative preparation is necessary.Matas training method shoud be adopted.Intraoperative meticulous dissection may reduce the incidence of postoperative complication.",
        "keywords": [
            "Carotid body tumor Diagnosis Therapy Carotid reconstruction"
        ],
        "authors": [
            {
                "name": "XIAO Jin-gang",
                "org": ",et al.Department of Oral and Maxillofacial Surgery,West China College of Stomatology,Sichuan University,Chengdu "
            },
            {
                "name": "LIU Lei",
                "org": ",et al.Department of Oral and Maxillofacial Surgery,West China College of Stomatology,Sichuan University,Chengdu "
            },
            {
                "name": "TIAN Wei-dong",
                "org": ",et al.Department of Oral and Maxillofacial Surgery,West China College of Stomatology,Sichuan University,Chengdu "
            }
        ],
        "venue": "Journal of Oral Science Research",
        "year": 2006
    },
    "Pd7AFOV2": {
        "id": "Pd7AFOV2",
        "title": "Study on chronic toxicity to rats of implantation of super-high molecular weight polylactate]",
        "abstract": "To make sure whether super-high molecular weight polylactate is toxic to the body after it has been implanted into the body for a long period.We implanted super-high molecular weight polylactate into the rats and took the specimens of blood at 3, 6, 9, 12 months after the operation. The changes of proteins, electrolyte, enzyme and other indices were observed. At the same time, the tissue around the implants were taken out to carry out the histological observation.At 3, 6, 9, 12 months after the operation, the levels of albumin, globulin, total bilirubin, direct bilirubin, triglyceride, glucose, K+, Na+, Cl-, Ca2+, alkaline phosphatase, glutamic-pyruvic transaminase in the blood plasma were all in the normal range; there were no significant differences between the experimental group and the control group. The level of lactate dehydrogenase increased slightly, but there was no statistically significant difference between the experimental group and the control group. There were no non-reversible immune rejection around the implants in the histological observation.Super-high molecular weight polylactate is not toxic to the body after it has been implanted into the animals for a long period.",
        "keywords": [
            "polylactate",
            "sd rat",
            "toxicity"
        ],
        "authors": [
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Sheng-wei Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei-dong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Qian Zheng",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Shi-cheng Wei",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Cheng-dong Xiong",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Zhe Peng",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2004
    },
    "hQfB1vsS": {
        "id": "hQfB1vsS",
        "title": "Preparation and characterization of bio-medical porous titanium by unconventional powder metallurgy",
        "abstract": "Porous titanium for biomedical applications was prepared by spark plasma sintering (SPS) technology, using atomized pure titanium powders as raw material and ammonium bicarbonate as space holder. Its phase composition and micro-morphology were analyzed by XRD and SEM, respectively. Mechanical properties and biocompatibility were also investigated. By adjusting the content of space holder and controlling process parameters, specimens can be obtained with porosities in the range of 50.3%~70.5% and pore diameters in the range of 100~300 \u03bcm, whose compressive strength(24.40~68.96MPa) and elastic modulus(1.010~1.287GPa) are similar to those of human can cellousbone. Ratosteoblasts can adhere to rough surface and grow into porous structure after co-cultured with porous titanium discs in vitro for 2 days, indicating that such material has good biocompatibility.",
        "keywords": [
            "Osteoblasts",
            "Porous titanium",
            "Space holder",
            "Spark plasma sintering(SPS)"
        ],
        "authors": [
            {
                "name": "Hui Zou",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Qi Lu",
                "org": "Chongqing University of Medical Sciences(Chongqing University of Medical Sciences,Chongqing Univ. of Medical Sciences,Chongqing Medical University),Chongqing,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Ying Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "LIAN Li-xian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Bo Shi",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Gongneng Cailiao yu Qijian Xuebao/Journal of Functional Materials and Devices",
        "year": 2010
    },
    "FHb2dVv6": {
        "id": "FHb2dVv6",
        "title": "Wnt5a regulates the cell proliferation and adipogenesis via MAPK-independent pathway in early stage of obesity.",
        "abstract": "The early stage of obesity is an important stage in the development of obesity. However there are few studies which explored the property or changes in obesity at early stage especially involving Wnt5a. The associated gene expression of Wnt5a on cell regeneration and the effect of Wnt5a on rat adipocyte-derived stem cell (rASC) proliferation and adipogenesis need additional study. Here, we investigated the changes in obesity at early stage and how Wnt5a regulates rASC regeneration, proliferation and adipogenesis. Our data revealed that obesity at early stage measured by Lee index presented a state with impaired adipogenesis and more infiltrated inflammatory cells but without significant changes in adipocyte sizes and inflammatory factors. The process might be associated with anti-canonical Wnt pathway and a reciprocal Wnt5a/JNK pathway. Besides the gene expression of Wnt5a decreased from cell passage 1 to passage 3. The cell proliferation was regulated by increasing dose of Wnt5a with the maximal effect at 50ng/ml and 50ng/ml Wnt5a suppressed adipogenic differentiation at middle-late stage of adipogenesis via anti-\u03b2-catenin and a mitogen-activated protein kinase (MAPK) signaling-independent manner. Accordingly, the research helps to gain further insights into the early stage of obesity and its associated changes on a cellular and molecular level.",
        "keywords": [
            "JNK signaling pathway",
            "Wnt5a",
            "adipogenesis",
            "adipose-derived stem cell (ASCs)",
            "obesity",
            "\u03b2-catenin pathway"
        ],
        "authors": [
            {
                "name": "Qi Tang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P.R. China."
            },
            {
                "name": "Chang Chen",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P.R. China."
            },
            {
                "name": "Yan Zhang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P.R. China."
            },
            {
                "name": "Minjia Dai",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P.R. China."
            },
            {
                "name": "Yichen Jiang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P.R. China."
            },
            {
                "name": "Hang Wang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P.R. China."
            },
            {
                "name": "Mei Yu",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P.R. China."
            },
            {
                "name": "Wei Jing",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P.R. China."
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P.R. China."
            }
        ],
        "venue": "Cell biology international",
        "year": 2017
    },
    "FCvxVer6": {
        "id": "FCvxVer6",
        "title": "Alteration of gingival exposure and its aesthetic effect.",
        "abstract": "This study analyzed the computerized variations of gingival exposure (GE) in unattractive smiles and evaluate the aesthetic effect to determine the acceptable range of GE for attractiveness. Images of the frontal posed smile of 50 juvenile women were evaluated in terms of attractiveness by doctors and laypersons separately to select the most unaesthetic one. And the most unaesthetic smile was modified with Photoshop in 2 ways-lowering upper lip and lifting lower lip-and the same evaluators were asked to reevaluate the changed images. We found that the smile with the most significant GE was selected as the most unaesthetic one. The attractiveness ratings were significantly lower in the doctors' group than in the laypersons' group (P < 0.05). The acceptable range of GE in the doctors' group was 0.54 to 2.23 mm, and in the laypersons' group, it was 0.09 to 2.35 mm. Among the many contributors to an attractive smile, GE alteration is the principal one, but not the only, and although 0- to 2.3-mm GE is just an acceptable range; there is an attractive GE degree or point for every individual. Gingival exposure alteration must be balanced against the others in clinical treatment, especially in maxillofacial surgery for the gummy smile.",
        "keywords": [
            "gingival exposure",
            "gummy smile",
            "smile aesthetics"
        ],
        "authors": [
            {
                "name": "Jun Guo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Hani Gong",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Ding Bai",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "The Journal of craniofacial surgery",
        "year": 2011
    },
    "7O5lOt9J": {
        "id": "7O5lOt9J",
        "title": "Effect of distraction osteogenesis on circadian rhythm of proliferation index of mandibular osteoblast in goat]",
        "abstract": "The study was to investigate the circadian rhythm of the proliferation index (PI) of the mandibular osteoblast after distraction osteogenesis (DO) by a comparative study to explain the different rhythm characteristics.Forty-eight healthy goats were employed and divided randomly into DO group and control. Four weeks after the right side mandible of DO group was distracted, animals of the both groups were killed at 0:00, 4:00, 8:00, 12:00, 16:00, 20:00 time point subsequently. Samples of 2 cm x 2 cm x 0.5 cm bone tissue were excised from distracted zone of DO group and the right mental foramen zone of the control. Primary cell culture method was employed to isolate the osteoblast from bone tissue and a flow cytometric analysis was used to detect the PI of osteoblast. The data was analyzed with cosinor rhythmometry method and the different rhythm between the two groups were investigated.The PI in the two groups demonstrated cosinor waves. The mesor and amplitude in DO group were significant higher compared with the control(P < 0.05), but there was no significant difference for the acrophase between the two groups (P > 0.05).The PI of osteoblast after DO showed significant circadian rhythm. It is suggested that DO is helpful to promote osteoblast proliferation and bone regeneration.",
        "keywords": [],
        "authors": [
            {
                "name": "Jie Long",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Xiaohui Zheng",
                "org": ""
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2003
    },
    "SJIe0hIh": {
        "id": "SJIe0hIh",
        "title": "Cryopreserved dentin matrix as a scaffold material for dentin-pulp tissue regeneration.",
        "abstract": "Cryopreservation has been identified as an efficient approach to preserve tissue engineered products for a long term. Our prior studies have suggested that the treated dentin matrix (TDM) could be an ideal bioactive scaffold for dental tissue regeneration. In this study, we hypothesize that the cryopreservation could effectively maintain the survival and viability of dentinogenesis-related proteins of TDM and the cryopreserved dentin matrix (CDM) would provide the suitable biological scaffold and inductive microenvironment for the regeneration of dentin-pulp like tissue. CDM-3 and CDM-6 were prepared by cryopreserving TDM in liquid nitrogen (-196 \u00b0C) with cryoprotectant for 3 months and 6 months, respectively. Various biological characteristics of CDM, including mechanical properties, cell proliferation, and odontogenesis ability, were investigated. To further evaluate the inductive capacity of CDM, human dental follicle cells were encapsulated within CDM, and implanted the scaffold into a mouse model for 8 weeks, and the grafts were harvested and assessed histologically. The CDM showed superior mechanical properties than TDM. Compared to TDM, CDM can release more dentinogenesis-related proteins due to the larger pore diameter. Cell proliferation with the addition of CDM extract liquid was similar to that of TDM in the first five days. Human dental follicle cells, under the effect of CDM extract liquid, highly expressed bone sialoprotein, collagen-1, alkaline phosphatase, indicating that CDM, regarded as the inductive microenvironment, plays an important role in odontogenesis. Most importantly, in vivo, CDM could induce dental follicle cells to regenerate new dentin-pulp like tissues, such as dentinal tubules, predentin, collagen fibers, nerves, and blood vessels which were positive for dentin sialophosphoprotein, dental matrix protein-1, Tubulin, and collagen-1. In conclusion, CDM is an ideal biological scaffold material for human dentin-pulp like tissue regeneration. These findings indicated that TDM could be preserved as the tissue engineering scaffold that is readily available for patient treatments. Furthermore, the success of cryopreservation of TDM may also provide an insight into preserving other bioactive scaffold materials of tissue engineering.",
        "keywords": [
            "bioactive scaffold materials",
            "cryopreservation",
            "dentin matrix",
            "stem cells"
        ],
        "authors": [
            {
                "name": "Liang Jiao",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Chengdu 610041, Sichuan Province, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Chengdu 610041, Sichuan Province, PR China; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Chengdu 610041, Sichuan Province, PR China."
            },
            {
                "name": "Li Xie",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Chengdu 610041, Sichuan Province, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Chengdu 610041, Sichuan Province, PR China."
            },
            {
                "name": "Bo Yang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Chengdu 610041, Sichuan Province, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Chengdu 610041, Sichuan Province, PR China; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Chengdu 610041, Sichuan Province, PR China."
            },
            {
                "name": "Mei Yu",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Chengdu 610041, Sichuan Province, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Chengdu 610041, Sichuan Province, PR China."
            },
            {
                "name": "Zongting Jiang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Chengdu 610041, Sichuan Province, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Chengdu 610041, Sichuan Province, PR China."
            },
            {
                "name": "Lian Feng",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Chengdu 610041, Sichuan Province, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Chengdu 610041, Sichuan Province, PR China."
            },
            {
                "name": "Weihua Guo",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Chengdu 610041, Sichuan Province, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Chengdu 610041, Sichuan Province, PR China; Department of Pedodontics, West China School of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Chengdu 610041, Sichuan Province, PR China."
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Chengdu 610041, Sichuan Province, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Chengdu 610041, Sichuan Province, PR China; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Chengdu 610041, Sichuan Province, PR China."
            }
        ],
        "venue": "Biomaterials",
        "year": 2014
    },
    "U4x4ASPN": {
        "id": "U4x4ASPN",
        "title": "Expression of odontogenic and osteogenic genes in bone marrow mesenchymal stem cells with overexpression of mouse dentin sialophosphoprotein",
        "abstract": "Objective To observe the overexpression of dentin sialophosphoprotein (DSPP) in mouse bone marrow mesenchymal stem cells (BM-MSC) and the expression of specific gene involved in odontogenic and osteogenic differentiation in transfected cells. Methods Mouse bone marrow mesenchymal stem cells (BM-MSC) were cultured and then transfected with DSPP gene by adenovirus-mediated way in vitro. The transfection efficiency of DSPP gene was assessed by the marker gene green fluorescent protein (GFP). With having observed the morphological transformation of transfected BM-MSC, we studied whether the transfected BM-MSC would express odontogenic and osteogenic genes by RT-PCR. Results The mouse BM-MSC were obtained and the adenovirus mediated DSPP gene used to transfect BM-MSC successfully. The transfected efficiency was 42. 7%. The transfected BM-MSC were induced to differentiate into odontoblast-like cells and meanwhile expressed specific odontogenic and osteogenic differentiation genes such as DSPP, DMP1, Msx1/2, Pax9, Lhx6/7, Sox9, Cbfa1, Osx, Col I. Conclusion The bone marrow mesenchymal stern cells can make differentiation with the overexpression of dentin sialophosphoprotein and express specific odontogenic and osteogenic differentiation genes.",
        "keywords": [
            "Adenovirus odontogenic differentiation",
            "Bone marrow mesenchymal stem cells",
            "Dentin sialophosphoprotein"
        ],
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Rong-Rong Nie",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Ling Wu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei-Dong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2008
    },
    "5Ar5SOY5": {
        "id": "5Ar5SOY5",
        "title": "Bone regeneration by BMP-2 enhanced adipose stem cells loading on alginate gel.",
        "abstract": "Adipose stem cells (ASCs) have the potential to differentiate into a variety of cell lineages both in vitro and in vivo. In this study, ASCs were harvested from normal Sprague-Dawley (SD) rats and transfected by BMP-2 gene before they were loaded on alginate. The ability of bone regeneration was determined in rat critical-size cranial defects. An 8-mm diameter defect was created in the calvarias of 36 rats; these rats were divided into three groups. In experimental group, the defects were filled with alginate gel combined with BMP-2 transfected ASCs; in negative control group, the defects were filled with alginate gel mixed with normal ASCs; in blank controls, the defects were filled with cell-free alginate gel. Four rats of each group were killed and the cranial defect sites were observed at 4, 8 and 16 weeks after surgery. There was complete repair of cranial defects in experimental group using the alginate gel loading BMP-2 transfected ASC, but only partial repair in negative controls and in the blank control. The engineering approach combining BMP-2 enhanced ASCs with alginate gel can therefore stimulate bone regeneration and repair for the large size bone defects.",
        "keywords": [
            "Adipose stem cells",
            "BMP-2",
            "Transfection",
            "Alginate gel",
            "Bone regeneration"
        ],
        "authors": [
            {
                "name": "Yunfeng Lin",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 China"
            },
            {
                "name": "Ling Wu",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 China"
            },
            {
                "name": "Wei Jing",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 China"
            },
            {
                "name": "Xiaoyu Li",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 China"
            },
            {
                "name": "Yao Wu",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 China"
            },
            {
                "name": "Jie Long",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 China"
            }
        ],
        "venue": "Histochemistry and cell biology",
        "year": 2008
    },
    "TpVg2TLl": {
        "id": "TpVg2TLl",
        "title": "The Combination Use of Platelet-Rich Fibrin and Treated Dentin Matrix for Tooth Root Regeneration by Cell Homing",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weidong tian",
                "org": ""
            },
            {
                "name": "weihua guo",
                "org": ""
            },
            {
                "name": "bo yang",
                "org": ""
            },
            {
                "name": "li xie",
                "org": ""
            },
            {
                "name": "shujuan guo",
                "org": ""
            },
            {
                "name": "gang chen",
                "org": ""
            },
            {
                "name": "lei sheng",
                "org": ""
            },
            {
                "name": "baohui ji",
                "org": ""
            }
        ],
        "venue": "Tissue Engineering Part A",
        "year": 2015
    },
    "LACrIyYg": {
        "id": "LACrIyYg",
        "title": "Expression and secretion of human tumor necrosis factor gene transfected on human embryo myoblasts]",
        "abstract": "To observe human tumor necrosis factor-alpha (hTNF-alpha) expression and secreting level of human embryo myoblasts transfected by hTNF-alpha gene.Human embryo myoblasts were transfected with shuttle plasmid pSV23SHTNF containing hTNF-alpha gene by cationic liposomes DOSPER. The control group was only given equivalent liposomes except plasmid. After culturing for 24, 48, 72 and 96 hours, hTNF-alpha expression level of human embryo myoblasts was observed with immunocytochemistry staining, and hTNF-alpha secreting of human embryo myoblasts was analyzed by ELISA.After transfected by hTNF-alpha gene for 24, 48, 72 and 96 hours, the human embryo myoblasts displayed significant secretion of hTNF-alpha in the cultural supernatant (P < 0.05), and overexpression in cytoplasma and cell membrane.Transfection of hTNF-alpha gene to human myoblasts made myoblasts secrete high concentration of hTNF-alpha, implying it is feasible that transfecting muscle cells surrounding tongue carcinoma lesion with hTNF-alpha gene can prevent tongue carcinoma from intruding into deeper muscle tissue.",
        "keywords": [
            "human embryo myoblasts",
            "gene transfection",
            "human tumor necrosis factor-\u03b1",
            "gene expression"
        ],
        "authors": [
            {
                "name": "Zhen-Nan Gao",
                "org": "Key Lab. of Oral Biomedical Engineering of Ministry of Education, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Jia-Rang Cao",
                "org": ""
            },
            {
                "name": "Wei-Dong Tian",
                "org": ""
            },
            {
                "name": "Sheng-Wei Li",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            },
            {
                "name": "Chun-Hua Fu",
                "org": ""
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2005
    },
    "YTXAJned": {
        "id": "YTXAJned",
        "title": "Condyle replacement after tumor resection: comparison of individual prefabricated titanium implants and costochondral grafts.",
        "abstract": "The indications for temporomandibular joint (TMJ) reconstruction are well established, but the method of reconstruction is controversial. The purpose of this retrospective study was to compare individual prefabricated condyle implants and costochondral grafts in condyle reconstruction after tumor resection.We conducted a retrospective review of a case series with 28 patients treated with costochondral grafting and 23 patients treated with individual prefabricated titanium implants. For each patient, variables included both subjective (pain and interference with eating) and objective (interincisal distance) data.Baseline patient characteristics were similar in the 2 groups; all patients were followed for a minimum of 2 years. Patients in both groups showed an improvement in symptoms. Those treated with individual prefabricated implants had greater improvement and fewer complications than those in the costochondral group; also, more patients in the autogenous group required reoperation.Individual prefabricated condyle implants are effective in reconstruction of TMJ tumor defects. These prostheses are a viable choice in the setting of tumor resection and reconstruction, with improvement of jaw function, reduction of joint pain, and esthetic improvement.",
        "keywords": [
            "titanium"
        ],
        "authors": [
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Jie Long",
                "org": ""
            },
            {
                "name": "Fan Feng",
                "org": ""
            },
            {
                "name": "Lijuan Guo",
                "org": ""
            },
            {
                "name": "Chao Gao",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics",
        "year": 2009
    },
    "ffG46qFV": {
        "id": "ffG46qFV",
        "title": "Individual design and rapid prototyping in reconstruction of orbital wall defects.",
        "abstract": "We examined the application of individual digital design and rapid prototyping in the reconstruction of orbital wall defects for different stages of orbital volume (OV) changes.Patients with unilateral post-traumatic orbital defects underwent individual digital design and rapid prototyping to manufacture specific titanium mesh implants to create ideal OV recovery. Features of orbital wall fracture deformities and OV changes were analyzed and measured with 3-Dimensional Medical Surface Rendering image software system.Most cases involving enophthalmos and diplopia were rectified, except for 5 cases of enophthalmos and 2 cases of diplopia with fresh fractures and 11 cases of enophthalmos and 7 cases of diplopia cases with old fractures. Ocular movements and facial malformations were improved. The OV values between the uninjured and injured sides had a significant deviation (P < .05). The degree of enophthalmos had no significant deviation with OV changes pre- and postoperatively in the early fracture stages. The degree of enophthalmos in the old fracture stages had a significant deviation with OV changes pre- and postoperatively.This study showed that orbital wall fractures can be diagnosed in early fracture stages and that the degree of long-term enophthalmos can be predicted with 3-Dimensional Medical Surface Rendering software. Our results suggest that early-stage orbital wall fractures should recover OV as early as possible, and that advanced stage orbital wall fractures should overcorrect OV. The degree of accuracy and rational of OV reconstruction can be improved by appropriate individual digitalization design and rapid prototyping technology.",
        "keywords": [],
        "authors": [
            {
                "name": "Wei Tang",
                "org": "Associate Professor, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Peoples Republic of China"
            },
            {
                "name": "Lijuan Guo",
                "org": "Assistant Professor, Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, Peoples Republic of China"
            },
            {
                "name": "Jie Long",
                "org": "Associate Professor, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Peoples Republic of China"
            },
            {
                "name": "Hang Wang",
                "org": "Associate Professor, Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, Peoples Republic of China"
            },
            {
                "name": "Yunfeng Lin",
                "org": "Assistant Professor, Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, Peoples Republic of China"
            },
            {
                "name": "Lei Liu",
                "org": "Associate Professor, Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, Peoples Republic of China"
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons",
        "year": 2010
    },
    "MoEUrjES": {
        "id": "MoEUrjES",
        "title": "Molecular and cellular characterization during chondrogenic differentiation of adipose tissue-derived stromal cells in vitro and cartilage formation in vivo.",
        "abstract": "Human adipose tissue is a viable source of mesenchymal stem cells (MSCs) with wide differentiation potential for musculoskeletal tissue engineering research. The stem cell population, termed processed lipoaspirate (PLA) cells, can be isolated from human lipoaspirates and expanded in vitro easily. This study was to determine molecular and cellular characterization of PLA cells during chondrogenic differentiation in vitro and cartilage formation in vivo. When cultured in vitro with chondrogenic medium as monolayers in high density, they could be induced toward the chondrogenic lineages. To determine their ability of cartilage formation in vivo, the induced cells in alginate gel were implanted in nude mice subcutaneously for up to 20 weeks. Histological and immunohistochemical analysis of the induced cells and retrieved specimens from nude mice at various intervals showed obviously cartilaginous phenotype with positive staining of specific extracellular matrix (ECM). Correlatively, results of RT-PCR and Western Blot confirmed the expression of characteristic molecules during chondrogenic differentiation namely collagen type II, SOX9, cartilage oligomeric protein (COMP) and the cartilage-specific proteoglycan aggrecan. Meanwhile, there was low level synthesis of collagen type X and decreasing production of collagen type I during induction in vitro and formation of cartilaginous tissue in vivo. These cells induced to form engineered cartilage can maintain the stable phenotype and indicate no sign of hypertrophy in 20 weeks in vivo, however, when they cultured as monolayers, they showed prehypertrophic alteration in late stage about 10 weeks after induction. Therefore, it is suggested that human adipose tissue may represent a novel plentiful source of multipotential stem cells capable of undergoing chondrogenesis and forming engineered cartilage.",
        "keywords": [
            "cartilage oligomeric protein",
            "chondrogenic differentiation",
            "collagen",
            "lipoaspirate cells",
            "CR",
            " cancer",
            " immunology",
            " neurodegeneration",
            " apoptosis",
            " cell death",
            " cell growth",
            " differentiation"
        ],
        "authors": [
            {
                "name": "Yunfeng Lin",
                "org": ""
            },
            {
                "name": "En Luo",
                "org": ""
            },
            {
                "name": "Xizhe Chen",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            },
            {
                "name": "Ju Qiao",
                "org": ""
            },
            {
                "name": "Zhengbin Yan",
                "org": ""
            },
            {
                "name": "Zhiyong Li",
                "org": ""
            },
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Xiaohui Zheng",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Journal of cellular and molecular medicine",
        "year": 2005
    },
    "qy6rwcRy": {
        "id": "qy6rwcRy",
        "title": "Risk factors of recurrence and life-threatening complications for patients hospitalized with chronic suppurative osteomyelitis of the jaw.",
        "abstract": "Clinically, recurrence and life-threatening complications are challenging problems for chronic suppurative osteomyelitis of the jaw (CSOJ), but there is no quantitative analysis or report about the causes of or risk factors for the two problems to date. Doctors identify the causes or risk factors only through clinical experience. We performed a retrospective study of 322 patients with CSOJ to quantificationally analysed the risk factors for the abovementioned two problems by logistic regression analysis.A retrospective study of 322 patients hospitalized with CSOJ was performed. The socio-demographic and clinical characteristics were recorded. The risk factors for the above two problems were analyzed by logistic regression analysis. Frequency and percentage were used to indicate descriptive research factors. A univariate logistic regression analysis was performed to calculate the odds ratio (OR) and to identify independent risk factors. The independent risk factors were further identified by multivariate logistic regression analysis.An age from 6-12 years or > 65 years, pre-admission antibiotic administration, a lesion at the mandibular ramus, concurrent maxillofacial space infection (MSI), and conservation of pathogenic teeth were found to be risk factors for recurrence. An age > 65 years, admission temperature > 39 degree Celsius, admission white blood cell (WBC) count >15\u00d7109/L, pre-admission antibiotic administration, concurrent MSI, pre-existing diabetes, and respiratory difficulty were found to be risk factors for life-threatening complications.The results indicate that doctors should remain mindful of the risk factors listed above, and the management of CSOJ should be increasingly aggressive when the above risk factors are present, especially when the lesion is located at the mandibular ramus. In addition, pathogenic teeth must be extracted, and antibiotics should be administered properly.Clinicaltrials.gov (NCT01670422).",
        "keywords": [
            "logistic regression analysis",
            "life-threatening complications",
            "recurrence",
            "risk factors",
            "chronic suppurative osteomyelitis of the jaw",
            "internal medicine",
            "parasitology",
            "odds ratio",
            "tropical medicine",
            "retrospective studies",
            "medical microbiology"
        ],
        "authors": [
            {
                "name": "Lin Chen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Tangxin Li",
                "org": "Sun Yat-Sen University(Zhongshan University,Sun Yat-Sen University,Sun Yat-sen University),Guangzhou,China"
            },
            {
                "name": "Wei Jing",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Cai Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "BMC infectious diseases",
        "year": 2013
    },
    "w85aUM5K": {
        "id": "w85aUM5K",
        "title": "Proliferation and pluripotency potential of ectomesenchymal cells derived from first branchial arch.",
        "abstract": "Cranial neural crest-derived ectomesenchymal cells are multipotential progenitors that contribute to various tissue types during embryogenesis. Their potential to be expanded in culture as a monolayer and to be induced into different cell lineages in vitro has not been previously reported in detail. In this study, the ectomesenchymal cells in the first branchial arch were enzymatically isolated from the mandibular processes of BALB/c mice and were maintained in an intact state in a medium containing leukaemia inhibitory factor. Here, we first evaluated the proliferative activity of the cells after the third passage, using bromodeoxyuridine labelling and in situ hybridization of telomerase mRNA. Positive staining for expression of HNK-1, S-100 and vimentin confirmed that the population of stem cells originated from the ectomesenchyme, which did not express cytokeratin. Then we investigated the molecular and cellular characteristics of the ectomesenchymal cells during their differentiation towards neurogenic, endothelial, myogenic and odontogenic lineages. Expression of multiple lineage-specific genes and proteins was detected by utilizing a range of molecular and biochemical approaches when the cells were transferred to inductive medium. Histological and immunohistochemical analysis of the induced cells at various intervals indicated obvious phenotypic alteration and presence of specific proteins for the differentiated lineages, for example nestin, factor VIII, alpha-SMA and dentin sialophosphoprotein (DSPP), respectively. Correlatively, results of reverse transcription-PCR corroborated at mRNA level the expression of the characteristic molecules during differentiation. Therefore, it is suggested that the ectomesenchymal cells derived from the first branchial arch may represent a novel source of multipotential stem cells capable of undergoing expansion and variant differentiation in vitro.",
        "keywords": [],
        "authors": [
            {
                "name": "Yunfeng Lin",
                "org": ""
            },
            {
                "name": "Zhengbin Yan",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            },
            {
                "name": "Ju Qiao",
                "org": ""
            },
            {
                "name": "Wei Jing",
                "org": ""
            },
            {
                "name": "Ling Wu",
                "org": ""
            },
            {
                "name": "Xizhe Chen",
                "org": ""
            },
            {
                "name": "Zhiyong Li",
                "org": ""
            },
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Xiaohui Zheng",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Cell proliferation",
        "year": 2006
    },
    "NvP6Zvru": {
        "id": "NvP6Zvru",
        "title": "Culture and characteristics of human dental papilla cells in vitro]",
        "abstract": "To culture human dental papilla cells (HDPCs)and to study its cytobiological characters in vitro.HDPCs were isolated and cultured with explant culture technique in vitro; Type I collagen, fibronection and laminin were detected in HDPCs and its secreted matrix with the immunocyto-chemical stain; HDPCs were incubated in mineralized promoting solution containing 10 mmol/L beta-glycerophosphate, 100 mg/L of ascorbic acid and 10 nmol/L dexamethasone supplemented with 10% FBS and the form of mineralized nodules was tested with Alizarin Red S stainning.Cultured HDPCs in vitro were well growing in DMEM/F12. Type I collagen, fibronection and laminin staining were all positive in both HDPCs and its secreted matrix, and laminin was stained with bunchiness in matrix. Mineralized nodules formed after cultured 27 days by Alizarin Red S stainning.HDPCs isolated and cultured are well growing in vitro, have a capability of synthesizing and secreting matrix and in mineralized promoting solution, are able to form mineralizer, so, HDPCs have a capacity of seed cell of tissue engineering regeneration tooth.",
        "keywords": [
            "cell culture",
            "extracellular matrix",
            "dental papilla cell",
            "mineralization"
        ],
        "authors": [
            {
                "name": "Jia-Min Xie",
                "org": "Key Laboratory of Oral Biomedical Engineering Ministry of Education, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Wei-Dong Tian",
                "org": ""
            },
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Xi-Zhe Chen",
                "org": ""
            },
            {
                "name": "Xiao-Hui Zheng",
                "org": ""
            },
            {
                "name": "Tao Wang",
                "org": ""
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2005
    },
    "iMDEdnUg": {
        "id": "iMDEdnUg",
        "title": "A therapeutic strategy for spinal cord defect: human dental follicle cells combined with aligned PCL/PLGA electrospun material.",
        "abstract": "Stem cell implantation has been utilized for the repair of spinal cord injury; however, it shows unsatisfactory performance in repairing large scale lesion of an organ. We hypothesized that dental follicle cells (DFCs), which possess multipotential capability, could reconstruct spinal cord defect (SCD) in combination with biomaterials. In the present study, mesenchymal and neurogenic lineage characteristics of human DFCs (hDFCs) were identified. Aligned electrospun PCL/PLGA material (AEM) was fabricated and it would not lead to cytotoxic reaction; furthermore, hDFCs could stretch along the oriented fibers and proliferate efficiently on AEM. Subsequently, hDFCs seeded AEM was transplanted to restore the defect in rat spinal cord. Functional observation was performed but results showed no statistical significance. The following histologic analyses proved that AEM allowed nerve fibers to pass through, and implanted hDFCs could express oligodendrogenic lineage maker Olig2 in vivo which was able to contribute to remyelination. Therefore, we concluded that hDFCs can be a candidate resource in neural regeneration. Aligned electrospun fibers can support spinal cord structure and induce cell/tissue polarity. This strategy can be considered as alternative proposals for the SCD regeneration studies.",
        "keywords": [],
        "authors": [
            {
                "name": "Xinghan Li",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China ; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China ; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China."
            },
            {
                "name": "Chao Yang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China ; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China."
            },
            {
                "name": "Lei Li",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China ; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China ; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China."
            },
            {
                "name": "Jie Xiong",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China ; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China ; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China."
            },
            {
                "name": "Li Xie",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China ; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China."
            },
            {
                "name": "Bo Yang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China ; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China ; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China."
            },
            {
                "name": "Mei Yu",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China ; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China."
            },
            {
                "name": "Lian Feng",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China ; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China."
            },
            {
                "name": "Zongting Jiang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China ; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China."
            },
            {
                "name": "Weihua Guo",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China ; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China ; Department of Pedodontics, West China School of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China."
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China ; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China ; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China."
            }
        ],
        "venue": "BioMed research international",
        "year": 2015
    },
    "xnYecT9S": {
        "id": "xnYecT9S",
        "title": "Kinesis Histology Observation on Development of Mouse's Incisor Germ in Submaxilla",
        "abstract": "Objective:Dental developmental bioresearch has become a hot spot in the research of oral medical domain.The re-search about developmental mechanism of the mouse's incisor germ is few neither at home nor abroad.This study is to make dynamic ob-servation on the process of the development of the mouse's incisor germ so as to obtain the massage about the space-time position and the rule of shape changing at cell level.Methods:Embryo mice of 12,13,14,15,16,17,18 days old and suckling mice of 1,2,3 days old were selected.The jaw bones containing the incisor germ were observed under stereomicroscope.Then the jaws were isolated,fixed and embedded,and its serial sections were taken and stained by HE.dynamic observations of the histological sections were made under opti-cal microscope.Results:The results showed that cutting teeth of fetal mice were at the condition of bud stage,cap period,early bell-shaped at 13-day-old,16-day-old,18-day-old embryo mice,respectively.And cutting teeth of the1-day-old newborn mice were at the condition of late bell-shaped.Conclusions:This study explicated the space-time changing rules of development of mice' incisive teeth,which would provide an important basis of the experiment for further research of development of mice' incisive teeth.",
        "keywords": [
            "Incisor germ",
            "Kinesis histology observation",
            "Stomatology",
            "Dental development"
        ],
        "authors": [
            {
                "name": "FENG Zhi-yuan",
                "org": "Department of Oral and Maxillofacial Surgery,West China Hospital of Stomatology,Chengdu,,China"
            },
            {
                "name": "LIU Lei",
                "org": "Department of Oral and Maxillofacial Surgery,West China Hospital of Stomatology,Chengdu,,China"
            },
            {
                "name": "YANG Miao-miao",
                "org": "Department of Oral and Maxillofacial Surgery,West China Hospital of Stomatology,Chengdu,,China"
            },
            {
                "name": "ZHANG Yong",
                "org": "Department of Oral and Maxillofacial Surgery,West China Hospital of Stomatology,Chengdu,,China"
            },
            {
                "name": "LIN Yun-feng",
                "org": "Department of Oral and Maxillofacial Surgery,West China Hospital of Stomatology,Chengdu,,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "Department of Oral and Maxillofacial Surgery,West China Hospital of Stomatology,Chengdu,,China"
            }
        ],
        "venue": "Progress in Modern Biomedicine",
        "year": 2009
    },
    "vdryD3L9": {
        "id": "vdryD3L9",
        "title": "Research progress on the treatment of frontal sinus fracture",
        "abstract": "Only 5% to 12% patients who have craniomaxillofacial fractures have frontal sinus fractures. For the special physical location and the complex anatomical structure of frontal sinus, improper treatment to frontal sinus fractures would lead to a series of complications or sequelae, such as brain abscess, meningitis, subdural abscess, epidural abscess and superior sagittal sinus thrombosis. That would bring greater suffering to patients and even life-threatening. In recent years, there are divergent views on the principles of the treatment of frontal sinus fractures by the great development of equipments and materials. This article summarizes various views of the frontal sinus fracture treatment principles and the methods in recent years, and gives a comprehensive overview of the current progress of the frontal sinus fracture treatment-related.",
        "keywords": [
            "treatment",
            "frontal sinus",
            "fracture"
        ],
        "authors": [
            {
                "name": "GONG Ha-ni",
                "org": "Dept. of Traumatic and Plastic Surgery, West China College of Stomatology, Sichuan University, Chengdu , China"
            },
            {
                "name": "GUO Jun",
                "org": "Dept. of Traumatic and Plastic Surgery, West China College of Stomatology, Sichuan University, Chengdu , China"
            },
            {
                "name": "TANG Wei",
                "org": "Dept. of Traumatic and Plastic Surgery, West China College of Stomatology, Sichuan University, Chengdu , China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "Dept. of Traumatic and Plastic Surgery, West China College of Stomatology, Sichuan University, Chengdu , China"
            }
        ],
        "venue": "International Journal of Stomatology",
        "year": 2010
    },
    "tFc0xayl": {
        "id": "tFc0xayl",
        "title": "Screening for genes affecting tooth shape formation",
        "abstract": "The dental germ develops in a temporal and spatial manner that is similar to the fertilized egg. Studies on the regulation of tooth development are beneficial for increasing our understanding of the regulation of the development of other tissues and organs. Nowadays the studies of developmental biology focus on genomics. The main theme of the study is to screen for genes affecting murine tooth shape formation, which is the foundation to regenerate teeth with different shapes Initially the whole mouse genome oligo microarray was used to compare the gene expression patterns between teeth with different shapes. Then biological information analysis was used for further selection. At last real-time polymerase chain reaction (real-time PCR) was used to certify different expression levels of genes. The six genes Amelx, Cart1, Dkk1, Hand2, Msx1 and Sfrp2, were thought to be involved in murine tooth shape formation. This study is the first to report roles for Cart1 and Sfrp2 in tooth shape formation Additionally, many other differentially expressed genes screened by microarray are also worthy of further investigation, all of which may have some correlation on development. \u00a9 2012 American Scientific Publishers. All rights reserved.",
        "keywords": [
            "Cart1",
            "Dental papillae",
            "Gene expression",
            "Regeneration",
            "Sfrp2",
            "Tooth shape formation",
            "Wnt signaling pathway"
        ],
        "authors": [
            {
                "name": "Miaomiao Yang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yongqing Ma",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Jing",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jie Long",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Advanced Science Letters",
        "year": 2012
    },
    "GL7kqw7D": {
        "id": "GL7kqw7D",
        "title": "The gene expression patterns of bone-marrow mesenchymal stem cells under different osteogenic induction",
        "abstract": "Objective: To investigate the molecular mechanism of osteogenetic differentiation of bone-marrow mesenchymal stem cells (BMSCs) and the probability using the BMSCs to gene therapy for bone fractures. Methods: By gradient centrifugation and adherence to the culture plastic, the MSCs were separated and purified from mouse bone marrow. The BMSCs then were cultured and sub-cultured in the osteogenetic medium (100 nmol/L Dexamethasone, 10 mmol/L \u03b2-glycerophosphate and 50 mg/mL ascorbic acid, osteogenic supplements, OS-medium) or the recombinant human bone morphogenetic protein-2 (rhBMP-2, 500 ng/mL) for the mineralized inductions of osteogenesis, and stained by alizarin red in inducing week 1 and 2 for the identification of calcium nodule formed. The gene expressions of Runx2, Osx, OCN, and Col I were detected by RT-PCR on day 1, 2 and 3 after doing the osteogenetic inductions. Results: The BMSCs induced by OS-medium and rhBMP-2 were both of positive Ca nodules with alizarin red. However, the Ca nodule induced by OS-medium formed in 1 inducing week, but the one done by rhBMP-2 occurred in 2 inducing weeks, which meant it was a late for one week. In the OS-group, the mRNA of Runx2 could not be detected on inducing day 1, 2 and 3, but the Osx mRNA appeared on inducing day 2 and 3, and also the mRNAs of OCN and Col I could be detected in all the three inducing days. In rhBMP-2 group, the Runx2 gene expressed on inducing day 2, the Osx gene expressed on inducing day 2 and 3, the OCN and Col I genes expressed on inducing day 1, 2 and 3. Conclusion: The BMSCs induced by OS-medium are more likely to form bone nodules than that of rhBMP-2, because of their simpler mechanisms to differentiate into osteoblasts.",
        "keywords": [
            "Bone morphogenetic protein-2",
            "Gene expression pattern",
            "Mesenchymal stem cell",
            "Osteogenic differentiation"
        ],
        "authors": [
            {
                "name": "Rui Ping Duan",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Ling Wu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "LIN Yun-feng",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2006
    },
    "fUlHUnG8": {
        "id": "fUlHUnG8",
        "title": "Analysis of Maxillofacial Injuries of 419 Patients with Emphasis on Soft-tissue Injuries in the Wenchuan Earthquake",
        "abstract": "Objective:To analyze retrospectively the 419 patients'maxillofacial injuries with emphasis on soft-tissue injuries in the Wenchuan earthquake,and to provide reference on the treatment in earthquake.Methods:Analysis and investigate 2944 cases who were injured in the Wenchuan earthquake,in which there are 419 injured maxillofacial,accompanied by soft tissue injuries of 381.Investating 419 patients'maxillofacial injuries with emphasis on soft-tissue injuries in the earthquake and using a database to analyze the results. Results:Of the 419 maxillofacial patients,381 patients got soft-tissue injuries(91%).There was no significant difference between male and female.According to mechanism of injury,most patients were injuried by pressing and burying.The most common injury sites were frontal and zygomatic areas.In terms of injury types,there were more abrasions and lacerations.22%of the patients had local wound infections with a high rate.But general infection was very uncommon.Conclusions:Soft-tissue injuries caused by earthquake are different from others,especially on the mechanisms.We analyze the characteristics of maxillofacial injuries with emphasis on the soft-tissue injuries after the Wenchuan earthquake,so as to improve our medical emergency system when such dizasters happens again.",
        "keywords": [
            "wenchuan earthquake",
            "maxillofacial trauma",
            "soft-tissue injuries",
            "injury characteristics",
            "face",
            "soft tissues"
        ],
        "authors": [
            {
                "name": "SHENG Lei",
                "org": "Department of Maxillofacial Surgery West China College of Stomatology,Sichuan University,Chengdu 61004l,Sichuan Province, China"
            },
            {
                "name": "LI Rui",
                "org": "Department of Maxillofacial Surgery West China College of Stomatology,Sichuan University,Chengdu 61004l,Sichuan Province, China"
            },
            {
                "name": "WANG Hang",
                "org": "Department of Maxillofacial Surgery West China College of Stomatology,Sichuan University,Chengdu 61004l,Sichuan Province, China"
            },
            {
                "name": "LONG Jie",
                "org": "Department of Maxillofacial Surgery West China College of Stomatology,Sichuan University,Chengdu 61004l,Sichuan Province, China"
            },
            {
                "name": "TANG Wei",
                "org": "Department of Maxillofacial Surgery West China College of Stomatology,Sichuan University,Chengdu 61004l,Sichuan Province, China"
            },
            {
                "name": "LIU Lei",
                "org": "Department of Maxillofacial Surgery West China College of Stomatology,Sichuan University,Chengdu 61004l,Sichuan Province, China"
            },
            {
                "name": "GUO Li-juan",
                "org": "Department of Maxillofacial Surgery West China College of Stomatology,Sichuan University,Chengdu 61004l,Sichuan Province, China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "Department of Maxillofacial Surgery West China College of Stomatology,Sichuan University,Chengdu 61004l,Sichuan Province, China"
            }
        ],
        "venue": "Progress in Modern Biomedicine",
        "year": 2009
    },
    "XenZkSw5": {
        "id": "XenZkSw5",
        "title": "Progress in the materials, design and related technique clinical application of temporomandibular joint prosthesis",
        "abstract": "Objective: To summarize the materials, design, fit-shape and fixation techniques and clinical application of temporomandibular joint (TMJ) prosthesis. Data sources: An online search was undertaken to identify English articles about TMJ prosthesis published in Pubmed database from January 1998 to December 2006 using the key words of \"temporomandibular joint, joint prosthesis\". Study selection: The collected literatures about TMJ prosthesis were sorted, and those with good pertinence were selected. For the literatures of the same field, those published recently or in authorized journals were selected. Data extraction: Totally 69 literatures were collected, 28 were enrolled, and the other 41 were excluded, including 23 were irrelative with the aim of this study, and 18 were repetitive studies. Data synthesis: Joint prosthesis is one of the fields that develop the fastest in orthopedic surgery in recent 30 years. TMJ replacement aims to enhance the function of TMJ, alleviate pain, and prevent serious complication. With the rapid developments of material science, tissue engineering, joint biomechanics and other related subjects, TMJ prosthesis has been significantly improved in the materials, design, fit-shape and fixation techniques. People have developed from simply imitating the outline form and mechanical motor of TMJ to pay more attention to its pathological function. It is very significant to trace the new progress in hip prosthesis and knee joint, and apply the good outcomes in the design and manufacture of TMJ prosthesis. Conclusion: Prosthetic material plays leading and promoting roles in the development of joint prosthesis, good design, fit-shape and fixation are the necessary conditions for prosthesis to act its role, and it is also necessary to investigate joint biomechanics. TMJ prosthesis should be further investigated, and it has good prospect.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Tang You-chao",
                "org": "Central People's Hospital of Guangdong Province(Central People's Hospital of Guangdong Province,Huizhou Stomatological Hospital of Guangdong Province),,China"
            },
            {
                "name": "Tian Wei-dong",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Li Sheng-wei",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Journal of Clinical Rehabilitative Tissue Engineering Research",
        "year": 2007
    },
    "dHWhll2F": {
        "id": "dHWhll2F",
        "title": "Explant Culture: An Efficient Method to Isolate Adipose-Derived Stromal Cells for Tissue Engineering: ISOLATING ASCs BY EXPLANT CULTURE",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weidong tian",
                "org": ""
            },
            {
                "name": "yunfeng lin",
                "org": ""
            },
            {
                "name": "sixiu chen",
                "org": ""
            },
            {
                "name": "min zhou",
                "org": ""
            },
            {
                "name": "yuanding huang",
                "org": ""
            },
            {
                "name": "xingmei yang",
                "org": ""
            },
            {
                "name": "zhonghua xiong",
                "org": ""
            },
            {
                "name": "jingang xiao",
                "org": ""
            },
            {
                "name": "wei jing",
                "org": ""
            }
        ],
        "venue": "Artificial Organs",
        "year": 2010
    },
    "jLt9qsCh": {
        "id": "jLt9qsCh",
        "title": "Bone marrow mesenchymal stem cells combine with Treated dentin matrix to build biological root",
        "abstract": "A Nature Research Journal",
        "keywords": "",
        "authors": [
            {
                "name": "Shiwei Luo",
                "org": "Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"
            },
            {
                "name": "Fei Pei",
                "org": "Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"
            },
            {
                "name": "Wen Zhang",
                "org": "Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"
            },
            {
                "name": "Rui Li",
                "org": "Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"
            },
            {
                "name": "Wei He",
                "org": "Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"
            },
            {
                "name": "Shiwei Luo",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Fei Pei",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Weihua Guo",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Weidong Tian",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Shiwei Luo",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Fei Pei",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Weihua Guo",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Weihua Guo",
                "org": "Department of Pedodontics, West China School of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, China"
            }
        ],
        "venue": "Scientific Reports",
        "year": 2017
    },
    "3sGUWFoK": {
        "id": "3sGUWFoK",
        "title": "Expression of glutamyl aminopeptidase by osteogenic induction in rat bone marrow stromal cells.",
        "abstract": "Glutamyl aminopeptidase (GluAP, EC 3.4.11.7, ENPEP) is a 130-kDa homodimeric zinc metallopeptidase which specifically cleaves the N-terminal glutamate or aspartate residue of peptidic substrates such as cholecystokinin-8 or angiotensin (Ang) II, in vitro. We used a DNA microarray hybridization (Genechip Rat Expression Array 230A, Affymetrix Inc., Santa Clara, CA, USA) to demonstrate that GluAP was upregulated in osteogenic induced rat bone marrow stromal cells (BMSCs). To compare the expression of GluAP in the osteogenic differentiation and non-osteogenic differentiation of rat BMSCs in vitro, the cells were osteogenic induced in vitro. We also performed an MTT assay, alkaline phosphatase assay, alizarin red staining, and an immunohistochemical analysis to determine the osteogenic differentiation of BMSCs. The expression of GluAP was examined by real-time polymerase chain reaction (PCR). The real-time PCR results showed that GluAP was upregulated in osteogenic differentiated BMSCs in vitro, suggesting that GluAP may be correlated with the osteogenic differentiation of BMSCs.",
        "keywords": [
            "bone marrow stromal cells",
            "gluap",
            "gene expression",
            "empep",
            "osteogenic induction",
            "real time pcr",
            "zinc",
            "dna microarray",
            "alkaline phosphatase",
            "n terminal",
            "real time polymerase chain reaction",
            "glutamate"
        ],
        "authors": [
            {
                "name": "Yao Wu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jingang Xiao",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Ling Wu",
                "org": "16 Section 3(16 Section 3),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "16 Section 3(16 Section 3),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Cell biology international",
        "year": 2008
    },
    "tAvwmTUe": {
        "id": "tAvwmTUe",
        "title": "Clinical Study of Surgical Treatment for Condylar Fractures",
        "abstract": "Objective: To investigate surgical treatment for condylar fractures and evaluate the indications,key points and complications. Methods: A retrospective study was based on 116 condylar fractures patients treated by operation within recent 5 year. All cases were radiologically and clinically examinated, including occlusion,mouth opening,pattern of mouth opening, nerve damages, temporomandibular disorders and facial symmetry. Open reduction and internal fixation or removal of mandibular condyle was choosed according to clinical symptom of condylar fractures. Results: All cases recovered well, their facial appearance and function improved greatly. There were 2 malocclusion but normal mouth opening, and 1 restriction of mouth opening in 116 cases.The rate of anatomical reduction was 94.8 percent according to X-ray inspection.15 patients below 12 years old with condylar fractures healed well, all of which had no severe complications postoperatively. Conclusion: Applying rigid internal fixation technique is a good method to treat condylar fracture. Resorption plate with internal fixation based on anatomical reduction is an ideal procedure to treat severely displaced or dislocated condylar neck and subcondylar fracture for children.",
        "keywords": [
            "Rigid internal fixation Condylar fracture Treatment"
        ],
        "authors": [
            {
                "name": "XIAO Jin-gang",
                "org": ", et al. Department of Traumatic and Plastic Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu "
            },
            {
                "name": "LIU Lei",
                "org": ", et al. Department of Traumatic and Plastic Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu "
            },
            {
                "name": "TIAN Wei-dong",
                "org": ", et al. Department of Traumatic and Plastic Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu "
            }
        ],
        "venue": "Journal of Oral Science Research",
        "year": 2007
    },
    "yZyV5qq8": {
        "id": "yZyV5qq8",
        "title": "Effects of \u03b3-secretase inhibition on the proliferation and vitamin D3 induced osteogenesis in adipose derived stem cells",
        "abstract": "As a gamma-secretase inhibitor, DAPT has been widely used to evaluate the biological behaviors and Notch signaling pathway in various cells. This study was aimed to examine the effects of DAPT on the growth and vitamin D(3) induced osteogenesis in adipose derived stem cells (ASCs). The cells were treated with or without DAPT and induced to osteoblastic lineage in the presence of vitamin D(3). Alizarin red staining and real-time PCR results indicated that the addition of DAPT to vitamin D(3) treatments enhanced osteogenesis in ASCs. According to the fold increase and colony-forming unit assay results, the cells cultured in DAPT exhibited lower proliferation rate than those cultured in control medium. Hey1, expressed in the nucleus of ASCs to act as a transcriptional repressor, was downregulated when Notch signaling was inhibited by DAPT. Whereas the expression of Runx2 increased in the nucleus of osteogenic induced ASCs after DAPT treatment. This study demonstrated that DAPT reduced the proliferation and enhanced the osteogenesis in ASCs via regulation of Notch and Runx2 expression.",
        "keywords": [
            "Notch signaling pathway",
            "Vitamin D 3",
            "Adipose derived stem cells",
            "DAPT",
            "Osteogenesis"
        ],
        "authors": [
            {
                "name": "Wei Jing",
                "org": "State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, 14#, 3rd Section of Renmin South Road, Chengdu 610041, China"
            },
            {
                "name": "Zhonghua Xiong",
                "org": "Department of Intensive Care Unit, Sichuan Cancer Hospital & Research Institute, Chengdu, China"
            },
            {
                "name": "Xiaoxiao Cai",
                "org": "State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, 14#, 3rd Section of Renmin South Road, Chengdu 610041, China"
            },
            {
                "name": "Yuanding Huang",
                "org": "State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, 14#, 3rd Section of Renmin South Road, Chengdu 610041, China"
            },
            {
                "name": "Xiaoyu Li",
                "org": "State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, 14#, 3rd Section of Renmin South Road, Chengdu 610041, China"
            },
            {
                "name": "Xingmei Yang",
                "org": "State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, 14#, 3rd Section of Renmin South Road, Chengdu 610041, China"
            },
            {
                "name": "Lei Liu",
                "org": "State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, 14#, 3rd Section of Renmin South Road, Chengdu 610041, China"
            },
            {
                "name": "Wei Tang",
                "org": "State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, 14#, 3rd Section of Renmin South Road, Chengdu 610041, China"
            },
            {
                "name": "Yunfeng Lin",
                "org": "sichuan university"
            },
            {
                "name": "Weidong Tian",
                "org": "sichuan university"
            }
        ],
        "venue": "Biochemical and Biophysical Research Communications",
        "year": 2010
    },
    "hgjCcEiL": {
        "id": "hgjCcEiL",
        "title": "Management of superolateral dislocation of the mandibular condyle: a retrospective study of 10 cases.",
        "abstract": "Superolateral dislocation of the mandibular condyle (SDMC) is rarely described. The best treatment for superolateral dislocation of the fractured mandibular condyle (SDMC) is debated. This study investigated selection of the timing and techniques used in treating these fractures.A retrospective clinical study was conducted on clinical data from 10 SDMC patients. Maximum mouth opening and occlusal relationships were compared following treatment using different techniques.The 10 patients were followed for 6-25 months. Patients who had dislocation for less than 1 week had condylar reduction and rigid internal fixation of the fractures. Mandibular sagittal split ramus osteotomy and articular reduction and fixation were performed in seven cases. Postoperative mouth opening and occlusal relationships were satisfactory in all patients with the exception of one case with mouth opening of only 27 mm.For all patients with superolateral dislocation, our first approach was to reduce the bone stump through surgery. When the dislocated joint had become adherent to the surrounding tissues and ankylosis developed, mandibular sagittal split ramus osteotomy was performed with good results.",
        "keywords": [
            "sagittal split osteotomy",
            "superolateral",
            "temporomandibular joint",
            "dislocation"
        ],
        "authors": [
            {
                "name": "Longduo Shen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Peng Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jia Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jie Long",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery",
        "year": 2014
    },
    "omBlYVfd": {
        "id": "omBlYVfd",
        "title": "A Retrospective Study on 225 Condylar Fracture Patients",
        "abstract": "Objective:The aim of this study was to summarize the treatments for condylar fracture,and to provide future clinical work for information.Method:A retrospective survey of 225 condylar fracture patients' case files was done.The age,sex,etiology,location of the fracture,degree of displacement,complicating injuries,and treatment of the patients were observed.Results:Condylar fracture happened mostly to 20-to 49-yearold males.Traffic injury was the highest factor that caused adults' condylar fracture,as falling in children and the old.The most common position where fracture occurred was the neck of the condylar process,meanwhile most condylar fracture was accompanied with mandibular mental fracture.Most of children and old patients took the conservative treatment,and most of the adult were operated.The high-position fractures and(or) the non-obviously displaced fractures mostly took the conservative treat-ment,however,middle-or low-position fractures,and(or) the obviously displaced fractures were mostly operated.Conclusions:Nowa-days,20-to 49-year-old males are most likely to have condylar fracture.Traffic injury is the highest factor that causes adults' condylar racture,as falling in children and the old.The treatments for condylar fracture include conservative treatment and operation,which depends on the age of the patient,location of the fracture,and degree of displacement.",
        "keywords": [
            "Retrospective study",
            "Condylar fracture",
            "Treatment"
        ],
        "authors": [
            {
                "name": "SHI Lei",
                "org": " Department of Oral and Maxillofacial Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu,,China; Department of Oral and Maxillofacial Surgery,Hainan Stomatological Hospital,Haikou,,China"
            },
            {
                "name": "TANG Yan-feng",
                "org": " Department of Oral and Maxillofacial Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu,,China"
            },
            {
                "name": "LIU Lei",
                "org": " Department of Oral and Maxillofacial Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu,,China"
            },
            {
                "name": "ZHENG Xiao-hui",
                "org": " Department of Oral and Maxillofacial Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu,,China"
            },
            {
                "name": "WANG Hang",
                "org": " Department of Oral and Maxillofacial Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu,,China"
            },
            {
                "name": "TIAN Weidong",
                "org": " Department of Oral and Maxillofacial Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu,,China"
            }
        ],
        "venue": "Progress in Modern Biomedicine",
        "year": 2009
    },
    "BVol55kd": {
        "id": "BVol55kd",
        "title": "The osteogenic response of undifferentiated human adipose-derived stem cells under mechanical stimulation.",
        "abstract": "The purpose of this study was to investigate the osteogenic response of human adipose-derived stem cells (hASCs) under mechanical and/or chemical stimulation. hASCs were divided into three groups. In group A, the cells were cultured without any stimulation, in group B, the cells were induced with chemical stimulation, and in group C, the cells were induced with a combination of chemical stimulation and stretch loading. Stretch loading and chemical stimulation were applied using a four-point bending apparatus (0.5 Hz, 2,000 \u00b5\u03b5, 2 h/day) and osteogenic differentiation medium, respectively. At the 1st, 2nd, 3rd, 5th and 7th day following initiation of stretch loading, we detected alkaline phosphatase activity, mRNA expression (RUNX2, ALPL, osteonectin, osteopontin and type I collagen) and protein expression (RUNX2 and osteopontin) by colorimetric assay, real-time PCR and Western blot methods, respectively. Alkaline phosphatase activity, mRNA expression and protein expression all increased in groups B and C along with the culture time, but were observed to be downregulated by the 7th day in group C (p < 0.05). Compared to group A, most of the above markers were significantly higher in groups B and C (p < 0.05). All of the above markers in group C were higher than those in group B before the 5th day (p < 0.05), except at the 1st day. These results indicated that stretch loading promoted osteogenic differentiation of hASCs and that the combination of mechanical and chemical stimulation could enhance the osteogenic capability up to the 5th day relative to chemical stimulation alone.",
        "keywords": [
            "chemical stimulation",
            "human adipose-derived stem cells",
            "osteogenic differentiation",
            "stretch loading"
        ],
        "authors": [
            {
                "name": "Hong-ming Du",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xiao-hui Zheng",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Li-ya Wang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Jing",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yun-feng Lin",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei-dong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jie Long",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Cells, tissues, organs",
        "year": 2012
    },
    "fJTG9e2I": {
        "id": "fJTG9e2I",
        "title": "Application of LeFort I osteotomy in the treatment of old maxillary fracture",
        "abstract": "Objective:To study the effects of LeFort I osteotomy in the treatment of old maxillary fracture.Methods:30 patients with old maxillary fracture were treated with LeFort I osteotomy,the rehabilitation of occluding relation and masticatory function were observed after operation.Results:28 patients had well-pleasing occluding relation and masticatory function; 2 patients dissatisfied with their masticatory function, because of unbalance of nerve-muscle after their occlusal plane were rebuilt.Conclusion:LeFort I osteotomy can be a method in the treatment of old maxillary fracture.",
        "keywords": [
            "Old fracture",
            "Maxillary bone",
            "LeFort I osteotomy"
        ],
        "authors": [
            {
                "name": "Liu Jiawu",
                "org": ", et al.Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu ,China"
            },
            {
                "name": "Liu Lei",
                "org": ", et al.Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu ,China"
            },
            {
                "name": "Tian Weidong",
                "org": ", et al.Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu ,China"
            }
        ],
        "venue": "Journal of Practical Stomatology",
        "year": 2007
    },
    "AsOgBS8w": {
        "id": "AsOgBS8w",
        "title": "Improved fat graft survival by different volume fractions of platelet-rich plasma and adipose-derived stem cells.",
        "abstract": "The success of soft-tissue augmentation is offset by the low survival rates of grafted fat tissue. Research shows that adipose-derived stem cells (ASCs) and platelet-rich plasma (PRP) are beneficial to tissue healing.To evaluate the long-term effects of different volume fractions of PRP combined with ASCs on fat graft.ASCs were isolated from human fat tissue, and PRP was obtained from human blood. Cell count kit-8 and real-time polymerase chain reaction (PCR) were used to evaluate the influence of PRP (0%, 10%, 20%, and 30%; volume/volume [v/v]) in medium on ASC proliferation and adipogenic differentiation, respectively. A novel lipoinjection consisting of granular fat, PRP, and ASCs was subcutaneously transplanted into nude mice. The grafts were volumetrically and histologically evaluated 10, 30, 60, and 90 days after transplantation.The addition of PRP improved ASC proliferation. Expression of adipogenic-related genes, peroxisome proliferator-activated receptor-\u03b3, lipoprotein lipase, and adipophilin were up-regulated in PRP-induced ASCs. Compared with other groups, granular fat grafts formed with 20% (v/v) and 30% (v/v) PRP significantly improved residual volumes. More intact adipocytes and capillary formation, but less vacuolization, were observed in the 20% (v/v) and 30% (v/v) PRP groups at 30, 60, and 90 days. However, no significant difference was observed between the 20% (v/v) and 30% (v/v) PRP groups in retaining fat grafts and improving histology.Fat grafting with 20% (v/v) PRP and ASCs constitutes an appropriate transplantation strategy for improving graft survival and provides a potential approach for soft-tissue restoration in plastic and reconstructive surgery.",
        "keywords": [],
        "authors": [
            {
                "name": "Feng Li",
                "org": "Dr F. Li is a Researcher at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Surgeon in the Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, P.R. China. Dr Guo is Associate Director at the State Key Laboratory of Oral Diseases and the National EngineeringLaboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Associate Professor in the Department of Pedodontics,West China School of Stomatology, Sichuan University, Chengdu, P.R. China. Dr K. Li is a Researcher at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Surgeon in the Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Central Sounth University, Changsha, P.R. China. Dr Yu is an Assistant Professor at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China. Drs Tang and Wang are Clinical Professors in the Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, P.R. China. Dr Tian is Director at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Clinical Professor in the Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, P.R. China."
            },
            {
                "name": "Weihua Guo",
                "org": "Dr F. Li is a Researcher at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Surgeon in the Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, P.R. China. Dr Guo is Associate Director at the State Key Laboratory of Oral Diseases and the National EngineeringLaboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Associate Professor in the Department of Pedodontics,West China School of Stomatology, Sichuan University, Chengdu, P.R. China. Dr K. Li is a Researcher at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Surgeon in the Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Central Sounth University, Changsha, P.R. China. Dr Yu is an Assistant Professor at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China. Drs Tang and Wang are Clinical Professors in the Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, P.R. China. Dr Tian is Director at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Clinical Professor in the Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, P.R. China."
            },
            {
                "name": "Kun Li",
                "org": "Dr F. Li is a Researcher at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Surgeon in the Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, P.R. China. Dr Guo is Associate Director at the State Key Laboratory of Oral Diseases and the National EngineeringLaboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Associate Professor in the Department of Pedodontics,West China School of Stomatology, Sichuan University, Chengdu, P.R. China. Dr K. Li is a Researcher at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Surgeon in the Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Central Sounth University, Changsha, P.R. China. Dr Yu is an Assistant Professor at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China. Drs Tang and Wang are Clinical Professors in the Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, P.R. China. Dr Tian is Director at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Clinical Professor in the Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, P.R. China."
            },
            {
                "name": "Mei Yu",
                "org": "Dr F. Li is a Researcher at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Surgeon in the Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, P.R. China. Dr Guo is Associate Director at the State Key Laboratory of Oral Diseases and the National EngineeringLaboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Associate Professor in the Department of Pedodontics,West China School of Stomatology, Sichuan University, Chengdu, P.R. China. Dr K. Li is a Researcher at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Surgeon in the Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Central Sounth University, Changsha, P.R. China. Dr Yu is an Assistant Professor at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China. Drs Tang and Wang are Clinical Professors in the Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, P.R. China. Dr Tian is Director at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Clinical Professor in the Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, P.R. China."
            },
            {
                "name": "Wei Tang",
                "org": "Dr F. Li is a Researcher at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Surgeon in the Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, P.R. China. Dr Guo is Associate Director at the State Key Laboratory of Oral Diseases and the National EngineeringLaboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Associate Professor in the Department of Pedodontics,West China School of Stomatology, Sichuan University, Chengdu, P.R. China. Dr K. Li is a Researcher at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Surgeon in the Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Central Sounth University, Changsha, P.R. China. Dr Yu is an Assistant Professor at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China. Drs Tang and Wang are Clinical Professors in the Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, P.R. China. Dr Tian is Director at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Clinical Professor in the Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, P.R. China."
            },
            {
                "name": "Hang Wang",
                "org": "Dr F. Li is a Researcher at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Surgeon in the Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, P.R. China. Dr Guo is Associate Director at the State Key Laboratory of Oral Diseases and the National EngineeringLaboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Associate Professor in the Department of Pedodontics,West China School of Stomatology, Sichuan University, Chengdu, P.R. China. Dr K. Li is a Researcher at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Surgeon in the Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Central Sounth University, Changsha, P.R. China. Dr Yu is an Assistant Professor at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China. Drs Tang and Wang are Clinical Professors in the Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, P.R. China. Dr Tian is Director at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Clinical Professor in the Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, P.R. China."
            },
            {
                "name": "Weidong Tian",
                "org": "Dr F. Li is a Researcher at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Surgeon in the Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, P.R. China. Dr Guo is Associate Director at the State Key Laboratory of Oral Diseases and the National EngineeringLaboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Associate Professor in the Department of Pedodontics,West China School of Stomatology, Sichuan University, Chengdu, P.R. China. Dr K. Li is a Researcher at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Surgeon in the Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Central Sounth University, Changsha, P.R. China. Dr Yu is an Assistant Professor at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China. Drs Tang and Wang are Clinical Professors in the Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, P.R. China. Dr Tian is Director at the State Key Laboratory of Oral Diseases and the National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu, P.R. China; and is a Clinical Professor in the Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, P.R. China."
            }
        ],
        "venue": "Aesthetic surgery journal / the American Society for Aesthetic Plastic surgery",
        "year": 2015
    },
    "yT1kCnO9": {
        "id": "yT1kCnO9",
        "title": "A Retrospective Study of Traumatic Temporal Hollowing and Treatment With Titanium Mesh",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jie long",
                "org": ""
            },
            {
                "name": "hani gong",
                "org": ""
            },
            {
                "name": "shijun duan",
                "org": ""
            },
            {
                "name": "wei tang",
                "org": ""
            },
            {
                "name": "jun guo",
                "org": ""
            },
            {
                "name": "weidong tian",
                "org": ""
            }
        ],
        "venue": "Annals of Plastic Surgery",
        "year": 2012
    },
    "zZur4R8T": {
        "id": "zZur4R8T",
        "title": "Digital design and individually fabricated titanium implants for the reconstruction of traumatic zygomatico-orbital defects.",
        "abstract": "Autogenous bone graft is the preferred method for the reconstruction of maxillofacial defects. As an additional choice, the aim of this study was to develop and test the application of individual digital planning, rapid prototyping titanium implants, and functional long-term results in the reconstruction of traumatic zygomatico-orbital defects. Six patients were treated with 3-dimensional digital surgery designs, digital locating template, and individually fabricated titanium implants. All patients were followed for a minimum of 18 months with a mean of 51.8 months. The recovery of facial contour and function was satisfactory in 4 patients. In the other 2 patients, 1 implant was removed after implant exposure caused by infection, and the other implant was removed because of persistent diplopia. Although the risk of implant exposure exists, individual digital planning procedures, rapid prototyping, digital locating templates, and titanium implants are still effective methods for reconstructing traumatic zygomatico-orbital defects. We believe that the appropriate choice of surgical cases is of great importance when using individually designed titanium implants to restore maxillofacial defects. The patient's age, health, medical history, local infection, location and extent of the bony defect, and remaining soft tissue volume should all be taken into consideration.",
        "keywords": [
            "individual digital design",
            "rapid prototyping",
            "reconstruction",
            "traumatic zygomatico-orbital defects"
        ],
        "authors": [
            {
                "name": "Jia Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Peng Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Huilian Lu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Longduo Shen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jie Long",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "The Journal of craniofacial surgery",
        "year": 2013
    },
    "Owl0mAi2": {
        "id": "Owl0mAi2",
        "title": "Restoration of critical-size defects in the rabbit mandible using porous nanohydroxyapatite-polyamide scaffolds.",
        "abstract": "Composite nanohydroxyapatite/polyamide (n-HA/PA) biomaterials have been indicated for bone defect reconstruction, where PA is added to enhance the toughness of n-HA. However, a comprehensive understanding of the biological performance of this implant material remains to be determined. In this study, the biological activity of n-HA/PA biomaterials was characterized in vitro by assessing the growth of bone marrow stromal cells (BMSCs), and in an in vivo rabbit model. To evaluate the n-HA/PA performance under different osteogenic conditions in vivo, implants were inserted to critical-size bone defects in the angle and body of the rabbit mandible. To determine the necessity of ectogenic BMSC-n-HA/PA hybrids at different implantation sites, both raw n-HA/PA materials and BMSC-seeded n-HA/PA hybrids were implanted. Bone formation was detected by radiology and histological studies. The results showed that n-HA/PA composites had great bioactivity, demonstrating significant BMSC proliferation, active alkaline phosphatase secretion, and stimulating the expression of osteogenic proteins (bone morphogenetic protein 2 [BMP2], osteoprotegerin [OPG], osteopontin [OPN], collagen type I [Col I], and osteocalcin [OCN]), in comparison to the control (polyethylene). At marrow-rich implantation sites (mandibular body), the amount of new bone formation was significant, but was not enhanced by the presence of BMSCs in the BMSC-n-HA/PA hybrids. However, the BMSC-n-HA/PA hybrids were essential for promoting bone formation in marrow-poor sites (mandibular angle). In conclusion, n-HA/PA biomaterials, which offer the advantage of enhanced mechanical performance over n-HA, exhibit significant bioactivity, including the capacity for bone regeneration at marrow-poor sites when implanted in combination with BMSCs.",
        "keywords": [],
        "authors": [
            {
                "name": "Jun Guo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Zhaosong Meng",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Gang Chen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Dan Xie",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yali Chen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Hang Wang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Jing",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jie Long",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weihua Guo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Tissue engineering. Part A",
        "year": 2012
    },
    "YG5jT03u": {
        "id": "YG5jT03u",
        "title": "The role of odontogenic genes and proteins in tooth epithelial cells and their niche cells during rat tooth root development.",
        "abstract": "The rodent incisor cervical loop and molar Hertwig's epithelial root sheath (HERS) are common models used for investigating tooth root generation. The purpose of the present study was to gain a better understanding of the molecular mechanisms mediating root development by determining the distinctive gene and protein expression profiles of each during different stages of development.In this study, we used quantitative real time reverse transcription-PCR and immunohistochemistry to analyse the expression levels of high mobility group AT-hook 2, ameloblastin, amelogenin, dentine sialoprotein, dentine matrix protein 1, osteocalcin, and bone sialoprotein in rat epithelial and mesenchymal cells isolated at postnatal days 4 and 8.Results showed that the expression of these genes and proteins was up-regulated in cervical loop epithelial cells, but decreased or unchanged in other cells during development. This increase in expression in the incisor cervical loop may be due to the interaction of the inner incisor dental papilla cells, which are the niche cells of cervical loop epithelial cells and demonstrated up-regulated expression of the corresponding proteins, revealing a complex and dynamic interplay of these molecules during neonatal tooth development.These findings provide novel insights into the molecular processes underlying crown development of rodent incisors, and contribute to our overall understanding of the pathogenic processes of tooth root dysontogenesis.",
        "keywords": [
            "cervical loop epithelial stem cells",
            "tooth development",
            "niche",
            "hertwig's epithelial root sheath"
        ],
        "authors": [
            {
                "name": "Yaneng Ge",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Ziren Kong",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yongwen Guo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weihua Guo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Archives of oral biology",
        "year": 2013
    },
    "Y7XMT2Cl": {
        "id": "Y7XMT2Cl",
        "title": "Database construction of maxillofacial trauma after Wenchuan earthquake using Microsoft Access 2000 system",
        "abstract": "Clinical data of 419 patients with maxillofacial injuries during initial one and half month after the Wenchuan earthquake from May 12th to June 30th, 2008 were collected, and the database was constructed using Microsoft Access 2000 combining with the questionnaire of maxillofacial trauma after 5.12 earthquake made by West China Hospital of Stomatology. A Microsoft Access 2000 database consisting of 419 patients with maxillofacial trauma was established and analyzed in one month. The database system was successfully constructed and operated smoothly, which had powerful capacity of information processing of case record. Microsoft Access 2000 is simple and practical in the construction of maxillofacial trauma database, which is beneficial to information management of case record and clinical, teaching and research work.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Rui Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Hang Wang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "YuLu Cao",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "ZiLiang Feng",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jingang Xiao",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xiaojuan Yang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Qi Lu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "LiJuan Guo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Journal of Clinical Rehabilitative Tissue Engineering Research",
        "year": 2009
    },
    "XCu5jk8g": {
        "id": "XCu5jk8g",
        "title": "Expression of exogenous or endogenous green fluorescent protein in adipose tissue-derived stromal cells during chondrogenic differentiation.",
        "abstract": "Pluripotent stem cells within the adipose stromal compartment, termed adipose-derived stromal cells (ASCs), have the potential to differentiate into a variety of cell lineages both in vitro and in vivo. Imaging with expression of exogenous or endogenous green fluorescent protein (GFP) reporters facilitates the detailed research on ASCs' physiological behavior during differentiation in vivo. This study was aimed to confirm whether ASCs expressing GFP still could be induced to chondrogenesis, and to compare the expression of exogenous or endogenous GFP in ASCs during chondrogenic differentiation. ASCs were harvested from inguinal fat pads of normal nude mice or GFP transgenic mice. Monolayer cultures of ASCs from normal mice were passaged three times and then infected with replication-incompetent adenoviral vectors carrying GFP genes. Allowed to recover for 5 days, Ad/GFP infected ASCs were transferred to chondrogenic medium as well as the ASCs from transgenic mice cultured in vitro over the same passages. The level of GFP in transgenic ASCs maintained stable till 3 months after chondrogenic induction. Whereas, high level of GFP expression in Ad/GFP infected ASCs could last for only 8 weeks and then declined stepwise. Important cartilaginous molecules such as SOX9, collagen type I, collagen type II, aggrecan, collagen type X were assessed using immunocytochemistry, RT-PCR, and Western Blot. The results indicated that no matter the GFP was exogenous or endogenous, it did not influence the chondrogenic potential of ASCs in comparison with the normal controls. Moreover, chondrogenic lineages from ASCs also underwent phenotypic modulation called dedifferentiation as a result of long-term culture in monolayers similar to normal chondrocytes.",
        "keywords": [
            "green fluorescent protein",
            "chondrogenic differentiation",
            "adipose tissue-derived stromal cells",
            "adipose tissue",
            "stem cell",
            "in vivo imaging",
            "adenoviral vector",
            "stromal cells",
            "transgenic mice"
        ],
        "authors": [
            {
                "name": "Yunfeng Lin",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology Sichuan University Chengdu 610041 P.R. China"
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology Sichuan University Chengdu 610041 P.R. China"
            },
            {
                "name": "Xizhe Chen",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology Sichuan University Chengdu 610041 P.R. China"
            },
            {
                "name": "Zhengbin Yan",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology Sichuan University Chengdu 610041 P.R. China"
            },
            {
                "name": "Zhiyong Li",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology Sichuan University Chengdu 610041 P.R. China"
            },
            {
                "name": "Ju Qiao",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology Sichuan University Chengdu 610041 P.R. China"
            },
            {
                "name": "Lei Liu",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology Sichuan University Chengdu 610041 P.R. China"
            },
            {
                "name": "Wei Tang",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology Sichuan University Chengdu 610041 P.R. China"
            },
            {
                "name": "Xiaohui Zheng",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology Sichuan University Chengdu 610041 P.R. China"
            }
        ],
        "venue": "Molecular and cellular biochemistry",
        "year": 2005
    },
    "FLhLwxVx": {
        "id": "FLhLwxVx",
        "title": "Study on Immune Response in Transplantation with Allogeneic Tissue-engineered Tooth Germ",
        "abstract": "Objective:To investigate the immune response of porcine transplanted with allogeneic tissue-engineered tooth germ and the influence of CD4/8 with inductive immunosuppressive drugs FK506.Methods Porcine tooth germ cells and ceramic bovine bone were used to construct tissue-engineered teeth and the mixture was implanted into mesenteries.Immunosuppressant FK506 was administrated after implantation.At special time points, the implants were retrieved for histological analysis.Results:There were obvious lymphocyte in-filtrations in the graft after implantation of mesenteries.The levels of CD4+T cells were significantly decreased and the further growth of allogeneic tissue engineered tooth germ in vivo was obvious after administration of FK506.Conclusions:Immunosuppressant FK506 can affect the immune response caused by the implantation of allogeneic tissue-engineered tooth germ.These studies provided a promising experimental foundation for the clinical application of tissue engineered tooth germ in future.",
        "keywords": [
            "Allograft",
            "Tooth germ",
            "Porcine",
            "Tissue-engineering"
        ],
        "authors": [
            {
                "name": "NIE Xin",
                "org": " Daping Hospital, the Third Military Medical University, Chongqing, , China; College of Stomatology, the Fourth Military Medical University, Xi'an, , China"
            },
            {
                "name": "YANG Mao-jin",
                "org": " Daping Hospital, the Third Military Medical University, Chongqing, , China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": " College of Stomatology, the West China University, Chengdu, , China"
            },
            {
                "name": "ZHANG Yong-jie",
                "org": " College of Stomatology, the Fourth Military Medical University, Xi'an, , China"
            },
            {
                "name": "GUO Bin",
                "org": " College of Stomatology, the Fourth Military Medical University, Xi'an, , China"
            },
            {
                "name": "JIN Yan",
                "org": " College of Stomatology, the Fourth Military Medical University, Xi'an, , China"
            }
        ],
        "venue": "Progress in Modern Biomedicine",
        "year": 2009
    },
    "0ZtmPAiH": {
        "id": "0ZtmPAiH",
        "title": "The Experimental Study of Intramuscular Degradation of Biphasic Calcium Phosphate Nanocomposite",
        "abstract": "Objective:Biphasic calcium phosphate nanocomposite (NanoBCP) is a kind of new scaffold which have a porous and 3D structure.The porosity of the scaffold was 60%-80% and the pore size was 100-400urn;This study is to observe the intramuscular degradation situation of NanoBCP.Methods:The NanoBCP ceramics were implanted into the muscle pouches in the leg of SD rat and implantation of the BCP\u3001HA were acted as control.At 4,12 and 24 weeks after implantation,the specimens were harvested and the degradation situation was evaluated by determing the weight loss rate,gross and histologic observation.Results:Degradation rate of the NanoBCP ceramics was 32%,degradation rate of the BCP ceramics was 13%,degradation rate of the HA ceramics was 32%.Histologic observation revealed most of the NanoBCP ceramics had broken up and the collapsed pieces had embedded in the newly formed fibrous tissue after 24 weeks' implantation.Conclusion:The prepared NanoBCP ceramic had partly degradable capability in muscle pouches in the leg of SD rat,and the degradation rate of the NanoBCP ceramics was greater than that of BCP and HA.",
        "keywords": [
            "Hydroxyapatite",
            "Biphasic calcium phosphate nanocomposite",
            "Bone tissue engineering",
            "Degradation rate"
        ],
        "authors": [
            {
                "name": "WANG Tao",
                "org": " Department of Stomatology,Hainan Provience People's Hospital,Hainan,,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": " Key Laboratory of Oral Biomedical Engineering,Ministry of Education,Sichuan University,Chengdu,,China"
            },
            {
                "name": "LI Sheng-wei",
                "org": " Key Laboratory of Oral Biomedical Engineering,Ministry of Education,Sichuan University,Chengdu,,China"
            },
            {
                "name": "LIAO Yun-mao",
                "org": " Key Laboratory of Oral Biomedical Engineering,Ministry of Education,Sichuan University,Chengdu,,China"
            }
        ],
        "venue": "Progress in Modern Biomedicine",
        "year": 2008
    },
    "t9sJVAM2": {
        "id": "t9sJVAM2",
        "title": "CAD based design sensitivity analysis and shape optimization of scaffolds for bio-root regeneration in swine.",
        "abstract": "Tooth root supports dental crown and bears occlusal force. While proper root shape and size render the force being evenly delivered and dispersed into jawbone. Yet it remains unclear what shape and size of a biological tooth root (bio-root), which is mostly determined by the scaffold geometric design, is suitable for stress distributing and mastication performing. Therefore, this study hypothesized scaffold fabricated in proper shape and size is better for regeneration of tooth root with approving biomechanical functional features. In this study, we optimized shape and size of scaffolds for bio-root regeneration using computer aided design (CAD) modeling and finite element analysis (FEA). Statical structural analysis showed the total deformation (TD) and equivalent von-mises stress (EQV) of the restored tooth model mainly concentrated on the scaffold and the post, in accordance with the condition in a natural post restored tooth. Design sensitivity analysis showed increasing the height and upper diameter of the scaffold can tremendously reduce the TD and EQV of the model, while increasing the bottom diameter of scaffold can, to some extent, reduce the EQV in post. However, increase on post height had little influence on the whole model, only slightly increased the native EQV stress in post. Through response surface based optimization, we successfully screened out the optimal shape of the scaffold used in tissue engineering of tooth root. The optimal scaffold adopted a slightly tapered shape with the upper diameter of 4.9 mm, bottom diameter of 3.4 mm; the length of the optimized scaffold shape was 9.4 mm. While the analysis also suggested a height of about 9 mm for a metal post with a diameter of 1.4 mm suitable for crown restoration in bio-root regeneration. In order to validate the physiological function of the shape optimized scaffold in vivo, we transplanted the shape optimized treated dentin matrix (TDM) scaffold, seeding with dental stem cells, into alveolar bone of swine and further installed porcelain crown. Results showed that tooth root has not only been successfully regenerated histologically but also performed masticatory function and maintained stable for three months after crown restoration. Our results suggested that TDM scaffold with 9.4 mm in length and 4.9 mm/3.4 mm in upper/bottom diameter is a suitable biological scaffold for tooth root regeneration. These results also provided a recommendable design protocol for fabricating other scaffolds in tooth root reconstruction.",
        "keywords": [
            "Scaffold",
            "Shape",
            "Design sensitivity analysis",
            "Optimization",
            "Tooth root",
            "Regeneration"
        ],
        "authors": [
            {
                "name": "Xiangyou Luo",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Bo Yang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Lei Sheng",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Jinlong Chen",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Hui Li",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Li Xie",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Gang Chen",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Mei Yu",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Weihua Guo",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; Department of Pedodontics, West China College of Stomatology, Sichuan University, No.14, 3rd Section, Renmin South Road, Chengdu 610041, PR China."
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            }
        ],
        "venue": "Biomaterials",
        "year": 2015
    },
    "WOm8Dn9V": {
        "id": "WOm8Dn9V",
        "title": "Construction and Odontogenic Potential of Injectable Tissue-engineered Tooth Germ",
        "abstract": "Objective:To evaluate the feasibility of injectable tissue-engineering tooth constructed with tooth germ cells and the odontogenic potential during implanted into renal capsule.Methods:Tooth germ cells from 4 days postnatal (dpn) SD rats were derived and cultured.After passage,the cells were mixed with the solution of dermal matrix from calf to construct the tissue-engineered teeth, and then,implanted into renal capsule with injector.Reconstructed germs were harvested and analysed with HE staining and Masson's staining to identify the odontogenic potential.Results:White mineralized tissues were found under the renal capsule 14 days after injec- tion.The development of distinctive pulp-dentin complex and enamel like structures were observed by HE staining.The green mineral- ized matrix around the dental papilla was further identified with Masson' s trichrome staining.Conclusions:Tooth germ cells still main- tain the genetic signals.The solution of dermal matrix used as scaffold is favorable for further interaction and rearrangement of tooth germ cells.After implantation,the tissue-engineered tooth germ has a potential to further mature,mineralize and form the tooth with reg- ular arranged structures.",
        "keywords": [
            "Rat",
            "Implantation",
            "Tissue engineering renal",
            "Odontogenic potential",
            "Tooth germ"
        ],
        "authors": [
            {
                "name": "GUO Bin",
                "org": ""
            },
            {
                "name": "ZOU Jing-cai",
                "org": ""
            },
            {
                "name": "QIN Rui-feng",
                "org": ""
            },
            {
                "name": "TIAN Wei-dong",
                "org": ""
            },
            {
                "name": "JIN Yan",
                "org": ""
            },
            {
                "name": "NIE Xin",
                "org": ""
            }
        ],
        "venue": "Progress in Modern Biomedicine",
        "year": 2007
    },
    "uf4ulDYQ": {
        "id": "uf4ulDYQ",
        "title": "Osteogenic induction of adipose-derived stromal cells: not a requirement for bone formation in vivo.",
        "abstract": "Osteogenic induction was regarded as an indispensable step for adipose-derived stromal cells (ADSCs) to have osteogenic ability. Non-induced ADSCs can also produce bone in vivo and heal skeletal defects. The present study aimed to compare the bone-forming ability of osteogenically induced ADSCs and non-induced ADSCs in vivo. Tissue-engineered constructs were prepared from osteogenically induced or non-induced ADSCs and porous hydroxyapatite/beta-tricalcium phosphate scaffolds. A scaffold without cells and an empty defect group were used as control. All were implanted in rat critical calvarial defects. After implantation for 6 and 12 weeks, bone formation was analyzed using histomorphometry and microcomputed tomography; there were no significant differences in the formation of new bone between osteogenically induced ADSCs and non-induced ADSCs (P > 0.05). In conclusion, osteogenic induction of ADSCs is not an indispensable step for bone formation in vivo. Non-induced ADSCs can also be used as seeding cells to construct bone tissue.",
        "keywords": [
            "adipose-derived stromal cells",
            "tissue engineering",
            "porous ceramic scaffold",
            "microcomputed tomography",
            "osteogenic induction",
            "stromal cells"
        ],
        "authors": [
            {
                "name": "Xiaoyu Li",
                "org": ""
            },
            {
                "name": "Jinfeng Yao",
                "org": ""
            },
            {
                "name": "Ling Wu",
                "org": ""
            },
            {
                "name": "Wei Jing",
                "org": ""
            },
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Yunfeng Lin",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            }
        ],
        "venue": "Artificial organs",
        "year": 2010
    },
    "ZdhXQmOZ": {
        "id": "ZdhXQmOZ",
        "title": "Fibronectin mRNA Expression During Healing Course in Mandibular Fracture",
        "abstract": "Objective: To investigate the expression of FN mRNA during mandibular fracture healing course. Methods: Rabbit mandibular bone fracture model was established, histologic specimen were obtained at different healing stages. The expression of FN mRNA was determined by in situ hybridization. Result: FN mRNA expressed obviously in fibroblasts and fibrocytes, it was also detected in some other cell types, such as vasal endothelial cells, chondrocytes, osteoclasts and some bone tissue cells. No FN mRNA signal was detected until the 3rd day after bone fracture, then the amounts increased, and reached peak value at 7\uff5e14 days. Expressional intensity decreased significantly 2 weeks later. Only faint signal was detected 1 month later. Conclusion: FN mRNA expresses in many topical cells during the healing process of bone fracture.",
        "keywords": [
            "mandibular fracture",
            "in situ hybridization",
            "fibronectin"
        ],
        "authors": [
            {
                "name": "CHENG Gang",
                "org": " Zhejiang Provincial People's Hospital, Hangzhou , Zhejiang Province"
            },
            {
                "name": "LIU Shao-hua",
                "org": " Qilu Hospital, Shandong University, Jinan , Shandong Province"
            },
            {
                "name": "LI Sheng-wei",
                "org": " West China College of Stomatology, Sichuan University, Chengdu , Sichuan Province, China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": " West China College of Stomatology, Sichuan University, Chengdu , Sichuan Province, China"
            },
            {
                "name": "LIU Lei",
                "org": " West China College of Stomatology, Sichuan University, Chengdu , Sichuan Province, China"
            }
        ],
        "venue": "Journal of Oral and Maxillofacial Surgery",
        "year": 2007
    },
    "qBUNrXlk": {
        "id": "qBUNrXlk",
        "title": "Ameloblastic carcinoma: An analysis of 12 cases with a review of the literature.",
        "abstract": "The diagnosis of ameloblastic carcinoma is often difficult and the optimal treatment methods remain controversial. The current study retrospectively investigated the optimal diagnosis and treatment methods of 12 ameloblastic carcinoma patients at the West China Hospital of Stomatology, Sichuan University (Chengdu, China), and 20 patients selected from the PubMed database, were reviewed. The clinical features, diagnosis and outcome of the different treatments were evaluated. Ameloblastic carcinoma occurred in 12 out of a total of 538 ameloblastoma patients; the majority were of the primary type. Of the 538 ameloblastoma patients, 294 were male, 244 were female with a male to female ratio of 1.2:1. The predilection age is 20-30 years, which accounts for 40% of the total. In total, 461 cases were in the mandible and 77 were located in the maxilla. The cure rate of the primary type and the recurrence rate of the secondary type tumors were higher in the patients from the West China Hospital of Stomatology compared with those reported in the literature. In particular, a case with a long-term survival of 30 years is presented, which is considered to be relatively rare. The evolution of the clinical course has experienced three stages: Ameloblastoma (1978) followed by metastatic ameloblastoma (2000) and finally ameloblastic carcinoma (2008). To avoid recurrence, wide local excision with postoperative radiation therapy is required. While novel therapeutic regimens should also be considered as appropriate, including carbon ion therapy and Gamma Knife stereotactic radiosurgery. However, controlled studies with larger groups of patients are required to increase the accuracy of results.",
        "keywords": [
            "ameloblastic carcinoma",
            "diagnosis",
            "radiotherapy",
            "treatment",
            "oncology",
            "molecular medicine",
            "bioinformatics",
            "apoptosis",
            "cell cycle",
            "biomedical research",
            "gene",
            "cell",
            "cancer"
        ],
        "authors": [
            {
                "name": "Jia Li",
                "org": "State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Hongming DU",
                "org": "State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Peng Li",
                "org": "State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Jingkui Zhang",
                "org": "State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Wei Tang",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            }
        ],
        "venue": "Oncology letters",
        "year": 2014
    },
    "IskHjGAv": {
        "id": "IskHjGAv",
        "title": "Combination of bone tissue engineering and BMP-2 gene transfection promotes bone healing in osteoporotic rats.",
        "abstract": "The aim of this study was to develop a feasible approach to promote bone healing in osteoporotic rats using autogenous bone tissue-engineering and gene transfection of human bone morphogenetic protein 2 (hBMP-2).Bone marrow stromal cells (BMSCs) from the left tibia of osteoporotic rats were transfected with the hBMP-2 gene in vitro which was confirmed by immunohistochemistry, in situ hybridization and Western blotting. Autogenous transfected or untransfected BMSCs were seeded on macroporous coral hydroxyapatite (CHA) scaffolds. Each cell-scaffold construct was implanted into a defect site which was created in the ramus of the mandible of osteoporotic rats. Four or eight weeks after implantation in situ hybridization was performed in BMSCs transfected with hBMP-2, X-ray examinations, histological and histomorphological analyses were used to evaluate the effect of tissue-engineered bone on osseous defect repair.Newly formed bone was observed at the margin of the defect 4 weeks after implantation with BMSCs transfected with BMP-2. Mature bone was observed 8 weeks after treatment. In the control group there was considerably less new bone and some adipose tissue was observed at the defect margins 8 weeks after implantation.Autogenous cells transfected with hBMP-2 promote bone formation in osteoporotic rats. BMSC-mediated BMP-2 gene therapy used in conjunction with bone tissue engineering may be used to successfully treat bone defects in osteoporotic rats. This method provides a powerful tool for bone regeneration and other tissue engineering.",
        "keywords": [
            "gene therapy",
            "bone regeneration",
            "bone morphogenetic protein 2",
            "tissue engineering",
            "osteoporosis",
            "mesenchymal stem cell",
            "hydroxyapatite"
        ],
        "authors": [
            {
                "name": "Youchao Tang",
                "org": "Huizhou Hospital of Stomatology(Huizhou Hospital of Stomatology,Huizhou Dental Hospital of Guangdong,Huizhou Stomatology Hospital,Huizhou Stomalogy Hospital),Huizhou,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yunfeng Lin",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jie Long",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Hang Wang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Cell biology international",
        "year": 2008
    },
    "3Zk3SLj6": {
        "id": "3Zk3SLj6",
        "title": "Cell-derived micro-environment helps dental pulp stem cells promote dental pulp regeneration.",
        "abstract": "The function of the dental pulp is closely connected to the extracellular matrix (ECM) structure, and ECM has received significant attention due to its biological functions for regulating cells. As such, the interaction between the ECM niche and cells is worth exploring for potential clinical uses.In this study, dental pulp stem cell (DPSC)-derived ECM (DPM) was prepared through cell culture and decellularization to function as the cell niche, and changes in DPSC behaviour and histological analysis of dental pulp tissue regeneration were evaluated following the DPM culture. DPM promoted the replication of DPSCs and exhibited retention of their mineralization. Then, the DPM-based culture strategy under odontogenic culture medium was further investigated, and the mineralization-related markers showed that DPSCs were regulated towards odontogenic differentiation. Dental pulp-like tissue with well-arranged ECM was harvested after a 2-month subcutaneous implantation in nude mice with DPM application. Additionally, DPSCs cultured on the plastic culture surface showed the up-regulation of mineralization makers in vitro, but there was a disorder in matrix formation and mineralization when the cells were cultured in vivo.DPM-based cultivation could serve as a cell niche and modulate DPSC behaviour, and this method also provided an alternative to harvest tissue-specific ECM and provided a strategy for ECM-cell interaction.",
        "keywords": "",
        "authors": [
            {
                "name": "Xuexin Zhang",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Hui Li",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Jingjing Sun",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Xiangyou Luo",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Hefeng Yang",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Li Xie",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Bo Yang",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weihua Guo",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weidong Tian",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            }
        ],
        "venue": "Cell proliferation",
        "year": 2017
    },
    "PfWzSIub": {
        "id": "PfWzSIub",
        "title": "Adipogenic and osteogenic differentiation of Lin(-)CD271(+)Sca-1(+) adipose-derived stem cells.",
        "abstract": "Adipose-derived stem cells (ASCs) have been defined as cells that undergo sustained in vitro growth and have multilineage differentiation potential. However, the identity and purification of ASCs has proved elusive due to the lack of specific markers and poor understanding of their physiological roles. Here, we prospectively isolated and identified a restricted homogeneous subpopulation of ASCs (Lin(-)CD271(+)Sca-1(+)) from mouse adipose tissues on the basis of cell-surface markers. Individual ASCs generated colony-forming unit-fibroblast at a high frequency and could differentiate into adipocytes, osteoblasts, and chondrocytes in vitro. Expansion of ASCs in a large quantity was feasible in medium supplemented with fibroblast growth factor-2 and leukemia inhibitory factor, without loss of adipogenic and osteogenic differentiation capacity. Moreover, we found that the transplanted ASCs can differentiate into adipocytes in adipogenic microenvironment in vivo and osteoblasts in osteogenic microenvironment in vivo. Thus we proved that Lin, CD271, and Sca-1 could be used as the specific markers to purify ASCs from adipose tissue. The method we established to identify ASCs as defined in vivo entities will help develop ASCs transplantation as a new therapeutic strategy for bone regeneration and adipose tissue regeneration in clinic.",
        "keywords": [],
        "authors": [
            {
                "name": "Jingang Xiao",
                "org": "State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China."
            },
            {
                "name": "Xiaojuan Yang",
                "org": ""
            },
            {
                "name": "Wei Jing",
                "org": ""
            },
            {
                "name": "Weihua Guo",
                "org": ""
            },
            {
                "name": "Qince Sun",
                "org": ""
            },
            {
                "name": "Yunfeng Lin",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            },
            {
                "name": "Wentong Meng",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Molecular and cellular biochemistry",
        "year": 2013
    },
    "hhM96n6q": {
        "id": "hhM96n6q",
        "title": "Quality assessment on reports of randomized controlled trials of oral and maxillofacial surgery in China]",
        "abstract": "To evaluate the report quality of randomized controlled trials (RCT) of oral and maxillofacial surgery in China during 2000-2009.A comprehensive electronic search was carried out through Chinese Biomedical Literature Database (CBM), VIP Database for Chinese Technical Periodicals (VIP) and China National Knowledge Infrastructure (CNKI), and 19 kinds of journals of stomatology in China were also hand-searched. We identified RCT published between 2000 and 2009, and classified into oral and maxillofacial surgery and labeled \"random\" and assessed the quality of these reports using the consolidated standards of reporting trials (CONSORT) statement.53 RCT articles were included. Reporting quality of the 53 articles was not high and the CONSORT score was 8.2 +/- 2.5.The reporting quality of RCT of oral and maxillofacial surgery in China is poor. The CONSORT statement should be used to standardize the reporting of RCT.",
        "keywords": [
            "randomized controlled trials",
            "consolidated standards of reporting trials",
            "stomatology",
            "reporting quality"
        ],
        "authors": [
            {
                "name": "Wenhang Dong",
                "org": " Dept. of Trauma and Plastic Surgery, West China School of Stomatology, Sichuan University, Chengdu , China; State Key Laboratory of Oral Diseases, Sichuan University, Chengdu , China"
            },
            {
                "name": "Chunjie Li",
                "org": " Dept. of Trauma and Plastic Surgery, West China School of Stomatology, Sichuan University, Chengdu , China"
            },
            {
                "name": "Chenyang Xiang",
                "org": " Dept. of Conservative Dentistry and Endodontics, West China School of Stomatology, Sichuan University, Chengdu , China"
            },
            {
                "name": "Zongdao Shi",
                "org": " Dept. of Trauma and Plastic Surgery, West China School of Stomatology, Sichuan University, Chengdu , China"
            },
            {
                "name": "Weidong Tian",
                "org": " Dept. of Trauma and Plastic Surgery, West China School of Stomatology, Sichuan University, Chengdu , China; State Key Laboratory of Oral Diseases, Sichuan University, Chengdu , China"
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2012
    },
    "IeyElE4W": {
        "id": "IeyElE4W",
        "title": "Comparison of odontogenic differentiation of human dental follicle cells and human dental papilla cells.",
        "abstract": "Classical tooth development theory suggests that dental papilla cells (DPCs) are the precursor cells of odontoblasts, which are responsible for dentin development. However, our previous studies have indicated that dental follicle cells (DFCs) can differentiate into odontoblasts. To further our understanding of tooth development, and the differences in dentinogenesis between DFCs and DPCs, the odontogenic differentiation of DFCs and DPCs was characterized in vitro and in vivo. DFCs and DPCs were individually combined with treated dentin matrix (TDM) before they were subcutaneously implanted into the dorsum of mice for 8 weeks. Results showed that 12 proteins were significantly differential, and phosphoserine aminotransferase 1 (PSAT1), Isoform 2 of hypoxia-inducible factor 1-alpha (HIF1A) and Isoform 1 of annexin A2 (ANXA2), were the most significantly differential proteins. These proteins are related to regulation of bone balance, angiogenesis and cell survival in an anoxic environment. Both DFCs and DPCs express odontogenic, neurogenic and peridontogenic markers. Histological examination of the harvested grafts showed that both DFCs and DPCs form pulp-dentin/cementum-periodentium-like tissues in vivo. Hence, DFCs and DPCs have similar odontogenic differentiation potential in the presence of TDM. However, differences in glucose and amino acid metabolism signal transduction and protein synthesis were observed for the two cell types. This study expands our understanding on tooth development, and provides direct evidence for the use of alternative cell sources in tooth regeneration.",
        "keywords": [
            "cell differentiation",
            "engineering",
            "immunophenotyping",
            "chemistry",
            "proteomics",
            "physics",
            "real time polymerase chain reaction",
            "biology",
            "dental papilla",
            "cell proliferation",
            "medicine"
        ],
        "authors": [
            {
                "name": "Lijuan Guo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jie Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xiangchen Qiao",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Mei Yu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Hang Wang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weihua Guo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "PloS one",
        "year": 2013
    },
    "uhCiPYqq": {
        "id": "uhCiPYqq",
        "title": "A study on transfection of green fluorescence protein gene into human adipose stromal cells in vitro",
        "abstract": "Objective: To make a comparison on the efficiency of two methods for transfecting Green Fluorescence Protein gene into human adipose tissue-derived stromal cells, and to study the biological properties and multipotential differentiation of gene-transfected cells. Methods: The human subcutaneous adipose tissue was obtained, digested with one volume of collagenase type I, and then cultured with BGJ b medium. After subculture and expansion, the human adipose tissue-derived stromal cells infected with Ad-GFP or liposome were observed and analyzed with fluorescence microscopy and flow cytometry to assess transfection efficiency. The growth curve of transfected adipose tissue-derived stromal cells was protracted. The adipose tissue-derived stomal cells were induced to differentiate into osteoblasts, and non-transfected cells were set as control. Results: 42.5%\u00b11.5% of the human adipose tissue-derived stomal cells infected with Ad-GFP were found to express GFP at a level higher than that of the control of liposome (11.4%). Infected adipose tissue-derived stromal cells were noted to form mineralized nodes by the use of Alizarin Red stain. Conclusion: The human adipose tissue-derived stromal cells infected with Ad-GFP can express higher level of GFP, and can maintain the ability of proliferation and differentiation as the non-infected human adipose tissue-derived stromal cells do. The infected adipose tissue-derived stromal cells with Ad-GFP can track the change of adipose tissue-derived stromal cells in the study of multipotential differentiation and can serve as cellular vehicles for systemic gene delivery.",
        "keywords": [
            "Differentiation",
            "Gene transfection",
            "Green fluorescence protein",
            "Human adipose tissue-derived stromal cell"
        ],
        "authors": [
            {
                "name": "LIN Yun-feng",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Jing",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "CHEN Xi-zhe",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Ju Qiao",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "LI Zhi-yong",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "YAN Zheng-bin",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Ling Wu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2006
    },
    "Lwd423FK": {
        "id": "Lwd423FK",
        "title": "Application and Prospect of Oral and Maxillofacial Digital Surgery",
        "abstract": "A new computer-aided surgical simulation technique for surgery has been developed. The purpose of this article is to review the literature with respect to the application of digital surgery such as individual digital design, rapid prototyping and surgical navigation in oral and maxillofacial surgery.",
        "keywords": [
            "restoration",
            "surgical navigation",
            "oral and maxillofacial region",
            "digital surgery",
            "rapid prototyping"
        ],
        "authors": [
            {
                "name": "TIAN Wei-dong",
                "org": "West China College of Stomatology, Sichuan University, Chengdu , Sichuan Province, China"
            },
            {
                "name": "TANG Wei",
                "org": "West China College of Stomatology, Sichuan University, Chengdu , Sichuan Province, China"
            }
        ],
        "venue": "Journal of Oral and Maxillofacial Surgery",
        "year": 2008
    },
    "Hw71dI4C": {
        "id": "Hw71dI4C",
        "title": "DNA Demethylation Rescues the Impaired Osteogenic Differentiation Ability of Human Periodontal Ligament Stem Cells in High Glucose",
        "abstract": "A Nature Research Journal",
        "keywords": "",
        "authors": [
            {
                "name": "Zhi Liu",
                "org": "Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Southwest Medical University, Luzhou 646000, P.R. China"
            },
            {
                "name": "Zongyi Yuan",
                "org": "Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Southwest Medical University, Luzhou 646000, P.R. China"
            },
            {
                "name": "Jingang Xiao",
                "org": "Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Southwest Medical University, Luzhou 646000, P.R. China"
            },
            {
                "name": "Zhi Liu",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China"
            },
            {
                "name": "Tian Chen",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China"
            },
            {
                "name": "Wenhua Sun",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China"
            },
            {
                "name": "Mei Yu",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China"
            },
            {
                "name": "Guoqing Chen",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China"
            },
            {
                "name": "Weihua Guo",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China"
            },
            {
                "name": "Weidong Tian",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China"
            },
            {
                "name": "Zhi Liu",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China"
            },
            {
                "name": "Tian Chen",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China"
            },
            {
                "name": "Wenhua Sun",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China"
            },
            {
                "name": "Mei Yu",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China"
            },
            {
                "name": "Guoqing Chen",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China"
            },
            {
                "name": "Weihua Guo",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China"
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China"
            },
            {
                "name": "Tian Chen",
                "org": "Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu 610041, P.R. China"
            },
            {
                "name": "Jingang Xiao",
                "org": "Orofacial Reconstruction and Regeneration Laboratory, Hospital of Stomatology, Southwest Medical University, Luzhou 646000, P.R. China"
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu 610041, P.R. China"
            }
        ],
        "venue": "Scientific Reports",
        "year": 2016
    },
    "yrwEiVsw": {
        "id": "yrwEiVsw",
        "title": "Dentin sialophosphoprotein-promoted mineralization and expression of odontogenic genes in adipose-derived stromal cells.",
        "abstract": "Dentin sialophosphoprotein (DSPP) is an extracellular matrix, typically dentin- and bone-specific gene, which plays an important role in dentin mineralization and tooth development. Adipose-derived stromal cells (ADSCs) are considered to contain a group of pluripotent mesenchymal stem cells which are capable of mineralization either in vitro or in vivo. In the present study, we hypothesized that overexpression of DSPP would promote mineralization in ADSCs. Our results showed that infection of DSPP-expressing adenovirus (Ad-DSPP) enhanced expression of genes related to mineralization, such as Cbfa1,Osx,BSP, OCN and DMP1 in ADSCs. Alkaline phosphatase activity was also confirmed in Ad-DSPP-infected ADSCs by cytochemistry and alkaline phosphatase activity assay. Mineralization assay indicated that Ad-DSPP-infected ADSCs were able to form mineralized nodules. Another finding in this study is that early odontogenic marker genes such as Msx1, Msx2, Lhx7 and Pax9 were expressed in DSPP-overexpressed ADSCs. Thus, our results suggested that overexpression of DSPP promoted mineralization of ADSCs, and together with the expression of early odontogenic marker genes, implied that these cells may differentiate into functional odontoblast-like cells.",
        "keywords": [
            "odontoblast-like cells",
            "adipose-derived stromal cells",
            "odontogenic genes",
            "mouse",
            "mineralization",
            "dentin sialophosphoprotein",
            "mesenchymal stem cell",
            "extracellular matrix",
            "stromal cells"
        ],
        "authors": [
            {
                "name": "Ling Wu",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Yao Wu",
                "org": ""
            },
            {
                "name": "Yunfeng Lin",
                "org": ""
            },
            {
                "name": "Xin Nie",
                "org": ""
            },
            {
                "name": "Wei Jing",
                "org": ""
            },
            {
                "name": "Ju Qiao",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            },
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Xiaohui Zheng",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Cells, tissues, organs",
        "year": 2008
    },
    "51Za3m64": {
        "id": "51Za3m64",
        "title": "The combination use of platelet-rich fibrin and treated dentin matrix for tooth root regeneration by cell homing.",
        "abstract": "Endogenous regeneration through cell homing provides an alternative approach for tissue regeneration, except cell transplantation, especially considering clinical translation. However, tooth root regeneration through cell homing remains a provocative approach in need of intensive study. Both platelet-rich fibrin (PRF) and treated dentin matrix (TDM) are warehouses of various growth factors, which can promote cell homing. We hypothesized that endogenous stem cells are able to sense biological cues from PRF membrane and TDM, and contribute to the regeneration of tooth root, including soft and hard periodontal tissues. Therefore, the biological effects of canine PRF and TDM on periodontal ligament stem cells (PDLSCs) and bone marrow mesenchymal stem cells (BMSCs) were evaluated respectively in vitro. Beagle dogs were used as orthotopic transplantation model. It was found that PRF significantly recruited and stimulated the proliferation of PDLSCs and BMSCs in vitro. Together, PRF and TDM induced cell differentiation by upregulating the mineralization-related gene expression of bone sialoprotein (BSP) and osteopotin (OPN) after 7 days coculture. In vivo, transplantation of autologous PRF and allogeneic TDM into fresh tooth extraction socket achieved successful root regeneration 3 months postsurgery, characterized by the regeneration of cementum and periodontal ligament (PDL)-like tissues with orientated fibers, indicative of functional restoration. The results suggest that tooth root connected to the alveolar bone by cementum-PDL complex can be regenerated through the implantation of PRF and TDM in a tooth socket microenvironment, probably by homing of BMSCs and PDLSCs. Furthermore, bioactive cues and inductive microenvironment are key factors for endogenous regeneration. This approach provides a tangible pathway toward clinical translation.",
        "keywords": [],
        "authors": [
            {
                "name": "Baohui Ji",
                "org": "1 State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University , Chengdu, People's Republic of China ."
            },
            {
                "name": "Lei Sheng",
                "org": ""
            },
            {
                "name": "Gang Chen",
                "org": ""
            },
            {
                "name": "Shujuan Guo",
                "org": ""
            },
            {
                "name": "Li Xie",
                "org": ""
            },
            {
                "name": "Bo Yang",
                "org": ""
            },
            {
                "name": "Weihua Guo",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Tissue engineering. Part A",
        "year": 2015
    },
    "6ZUTdefZ": {
        "id": "6ZUTdefZ",
        "title": "The Effects of Distraction Frequencies on the Expression of the Proliferating Cell Nuclear Antigen in the Osteoblasts of the Gap Tissue During Mandibular Distraction Osteogenesis",
        "abstract": "Objective:To evaluate the relationship between distraction frequencies and the proliferative activity of osteoblasts in the gap tissue and determine the proper distraction frequency for the mandibular distraction osteogenesis.Methods:Sixteen goats were assigned randomly into four groups.Group 1 served as the control,all the animals of group 2,3,and 4 underwent corticotomy in mental foramen zone of right mandible and distracted with different frequencies,the frequency of each group was 2 times per day (group 2),4 times per day (group 3) and 6 times per day (group 4).All the animals were sacrificed 4 weeks after distraction.The newly generated bones of the three experimental groups and the mandibles of the control group were obtained and the expression of proliferating cell nu- clear antigen (PCNA) in the osteoblasts in the gap tissue of the three experimental groups and in the mandibles of the control group were detected with immunohistochemistry study.Results:The PCNA positive expressing osteoblasts in distracted gap tissue of group 2,3 and 4 were significantly more than that of control,the PCNA positive expressing osteoblasts of group 3 and 4 were significantly higher than that of group 2.However,there was no significant difference between group 3 and group 4.Conclusions:The proliferative activity ofos- teoblasts in the distracted gap tissue increasesd with the rising of distraction frequency during mandibular distraction osteogenesis,this in- dicated that high frequency distraction may lead to the better new bone formation during mandibular distraction osteogenesis.",
        "keywords": [
            "Osteoblast",
            "Mandible",
            "Distraction osteogenesis",
            "Proliferating cell nuclear antigen"
        ],
        "authors": [
            {
                "name": "LONG Jie",
                "org": ""
            },
            {
                "name": "ZHENG Xiao-hui",
                "org": ""
            },
            {
                "name": "TIAN Wei-dong",
                "org": ""
            },
            {
                "name": "TANG Wei",
                "org": ""
            },
            {
                "name": "FAN Yu-bo",
                "org": ""
            },
            {
                "name": "LIU Lei",
                "org": ""
            },
            {
                "name": "LIN Yun-feng",
                "org": ""
            },
            {
                "name": "WANG Hang",
                "org": ""
            }
        ],
        "venue": "Progress in Modern Biomedicine",
        "year": 2007
    },
    "sMjFYCwu": {
        "id": "sMjFYCwu",
        "title": "Odontogenic differentiation of adipose-derived stem cells for tooth regeneration: necessity, possibility, and strategy.",
        "abstract": "Tooth regeneration using tissue engineering concepts is a promising biological approach to solving problems of tooth loss in elderly patients. The seeding cells, however, for tooth regeneration such as odontoblasts from dental germ, stem cells from dental pulp and deciduous teeth, and ectomesenchymal cells from the first branchial arch are difficult, even impossible to harvest in clinic. Bone marrow mesenchymal stem cells have odontogenic capacity, but their differentiation abilities significantly decrease with the increasing age of the donors. Therefore, the cells mentioned above are not practical in the clinical application of tooth regeneration in the old. Adipose derived stem cells have many clinical advantages over bone marrow mesenchymal stem cells, and their differentiation potential can be maintained with aging. Here we propose the hypothesis that adipose derived stem cells could be induced into odontogenic lineage and might be used as suitable seeding cells for tooth regeneration to replace the lost tooth of elderly patients.",
        "keywords": [
            "stem cell"
        ],
        "authors": [
            {
                "name": "Wei Jing",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Sichuan Province, Chengdu 610041, China"
            },
            {
                "name": "Ling Wu",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Sichuan Province, Chengdu 610041, China"
            },
            {
                "name": "Yunfeng Lin",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Sichuan Province, Chengdu 610041, China"
            },
            {
                "name": "Lei Liu",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Sichuan Province, Chengdu 610041, China"
            },
            {
                "name": "Wei Tang",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, No. 14, 3rd Sec., Ren Min Nan Road, Sichuan Province, Chengdu 610041, China"
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Medical hypotheses",
        "year": 2008
    },
    "wjGO2TTa": {
        "id": "wjGO2TTa",
        "title": "Establishment of three-dimensional finite element model of human mandible with Mimics and ANSYS software",
        "abstract": "Objective: To explore an effective method for the establishment of three-dimensional(3-D) finite element model of human mandible.Methods: Mandible of a male volunteer was scanned by spiral CT and the Dicom format images were imported into Mimics 10.01 software to reconstruct 3-D mandibular model,then remeshed.After meshed into entities in ANSYS 10.0 software,the model of.lis file and PREP7 file were transfered into Mimics for assignment.Once again,the PREP7 file was imported into Ansys to establish 3-D finite element model.Results: 3-D finite element model of the mandible was established precisely with 51 735 elements and 78 993 nodes.10 types of material were assigned to different parts of mandible according to CT gray value.Conclusion: 3-D finite element model of human mandible can be established by Mimics and ANSYS software precisely and effectively.",
        "keywords": [
            "Finite element method",
            "Mandible",
            "Computer-assisted",
            "Biomechanics"
        ],
        "authors": [
            {
                "name": "LI Peng",
                "org": ".1. Chengdu,Department of Oral and Maxillofacial Surgery,West China Hospital of Stomatology,Sichuan University,China"
            },
            {
                "name": "LIANG Rui",
                "org": "College of Architecture and Environment,Sichuan University,Chengdu"
            },
            {
                "name": "SHEN Longduo",
                "org": ".1. Chengdu,Department of Oral and Maxillofacial Surgery,West China Hospital of Stomatology,Sichuan University,China"
            },
            {
                "name": "LONG Jie",
                "org": ".1. Chengdu,Department of Oral and Maxillofacial Surgery,West China Hospital of Stomatology,Sichuan University,China"
            },
            {
                "name": "TIAN Weidong",
                "org": ".1. Chengdu,Department of Oral and Maxillofacial Surgery,West China Hospital of Stomatology,Sichuan University,China"
            },
            {
                "name": "TANG Wei",
                "org": ".1. Chengdu,Department of Oral and Maxillofacial Surgery,West China Hospital of Stomatology,Sichuan University,China"
            }
        ],
        "venue": "Journal of Practical Stomatology",
        "year": 2012
    },
    "zI9696l4": {
        "id": "zI9696l4",
        "title": "Experimental study on the fabrication of bioactive membrane for inducing bone regeneration]",
        "abstract": "The aim of this study was to develop a bioactive membrane for inducing bone regeneration. The membrane was composed of polylactic acid, collagen, recombinant human bone morphogenetic protein-2 (rhBMP-2). The PLA + collagen + rhBMP-2 membrane was fabricated by solvent-casting and cool-drying. The mechanic properties of this compound membrane were tested. The two surfaces of membrane were observed by SEM. Degradability of PLA was evaluated by SEM observation and molecular weight measure in vitro and in vivo. The compound membranes were implanted in rabbit muscles. The samples were obtained when animals were sacrificed at different periods: 2 weeks, 1, 2, 3, 6 months after surgery. The biodegradability and biocompatibility of the membrane were evaluated. The heterotopic bone inducing activity of BMP was identified. The results indicated that the strength at extension to failure of the compound membrane was 36.4MPa at 2.3% strain. The compound membrane was found bearing active factor on its coarse side, which can induce bone regeneration. After implantation in vivo, the membrane maintained the structure for three months and degraded in 6 months. Based on histological analysis, there was no obvious inflammation. Heterotopic bone was induced. We could conclude that the PLA + collagen + rhBMP-2 membrane is an absorbable compound membrane that possesses good biocompatibility, adequate mechanic properties and excellent property of bone induction. It could be applied as an ideal membrane for inducing bone regeneration.",
        "keywords": [],
        "authors": [
            {
                "name": "Weidong Tian",
                "org": "West China College of Stomatology, Sichuan University, Chengdu 610041, China. doubean1@sina.com"
            },
            {
                "name": "Chongyun Bao",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            },
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Xiaohui Zheng",
                "org": ""
            },
            {
                "name": "Shengwei Li",
                "org": ""
            },
            {
                "name": "Chengdong Xiong",
                "org": ""
            }
        ],
        "venue": "Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi",
        "year": 2004
    },
    "RoK29SZc": {
        "id": "RoK29SZc",
        "title": "Ectopic adipogenesis of preconditioned adipose-derived stromal cells in an alginate system.",
        "abstract": "Soft tissue substitutes are increasingly needed in reconstructive and plastic surgery, although difficulties arise when autografts or allografts have to provide long-term satisfactory replacement in soft tissue restoration. Adipose tissue engineering has highlighted the possibility of soft tissue restoration by using regeneration strategies. As few reports exist regarding adipose regeneration with alginate systems mixed with adipose-derived stromal cells (ASCs), the present study has attempted to evaluate the adipogenic differentiation of ASCs isolated from BALB/c mice in vitro and to define the potential of ASCs to form ectopic adipose tissue in an alginate system with subcutaneous implantation in nude mice. After 10 days induction in vitro, prediferentiated ASCs were seeded in an alginate gel system and implanted subcutaneously into the dorsum of nude mice. Adipogenesis of the newly formed tissue at 8 weeks post-implantation was confirmed by oil red O staining, reverse transcription/polymerase chain reaction, and Western blot analysis. This study thus provides evidence that the alginate system has the ability to form ectopic adipose tissue when mixed with predifferentiated ASCs. The results also supply clues for improving adipose tissue engineering and soft tissue defects repair in adults.",
        "keywords": [
            "adipose-derivedstem cells.predifferentiation. alginategel.tissue engineering.ectopic tissue differentiation.mouse balb/c",
            "Adipose-derived stem cells",
            "Predifferentiation",
            "Alginate gel",
            "Tissue engineering",
            "Ectopic tissue differentiation",
            "Mouse (BALB/c)"
        ],
        "authors": [
            {
                "name": "Wei Jing",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology No.14, 3rd Sec, Ren Min Nan Road Chengdu 610041 People\u2019s Republic of China"
            },
            {
                "name": "Yunfeng Lin",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology No.14, 3rd Sec, Ren Min Nan Road Chengdu 610041 People\u2019s Republic of China"
            },
            {
                "name": "Ling Wu",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology No.14, 3rd Sec, Ren Min Nan Road Chengdu 610041 People\u2019s Republic of China"
            },
            {
                "name": "Xiaoyu Li",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology No.14, 3rd Sec, Ren Min Nan Road Chengdu 610041 People\u2019s Republic of China"
            },
            {
                "name": "Xin Nie",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology No.14, 3rd Sec, Ren Min Nan Road Chengdu 610041 People\u2019s Republic of China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology No.14, 3rd Sec, Ren Min Nan Road Chengdu 610041 People\u2019s Republic of China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology No.14, 3rd Sec, Ren Min Nan Road Chengdu 610041 People\u2019s Republic of China"
            },
            {
                "name": "Xiaohui Zheng",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology No.14, 3rd Sec, Ren Min Nan Road Chengdu 610041 People\u2019s Republic of China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology No.14, 3rd Sec, Ren Min Nan Road Chengdu 610041 People\u2019s Republic of China"
            }
        ],
        "venue": "Cell and tissue research",
        "year": 2007
    },
    "DYbwmZIu": {
        "id": "DYbwmZIu",
        "title": "Comparison of the Odontogenic Differentiation Potential of Dental Follicle, Dental Papilla, and Cranial Neural Crest Cells.",
        "abstract": "During tooth development, cells originating from the neural crest serve as precursors to the cells in the dental follicle and dental papilla. Therefore, the current study aimed to understand the associations of cranial neural crest cells (CNCCs), dental follicle cells (DFCs), and dental papilla cells (DPCs) by performing a parallel comparison to evaluate their odontogenic differentiation capacities.In this study, we harvested the 3 cells from C57/green fluorescent protein-positive mice or embryos and compared the cell morphology, surface antigens, microstructures, and gene and protein expression. Under the odontogenic microenvironments provided by treated dentin matrix, the odontogenic differentiations of the 3 cells were further compared in vitro and in vivo.The gene levels of DFCs in neurofilament, tubulin, and nestin were close to the DPCs, and in alkaline phosphatase, osteopontin, dentin matrix protein 1, and dentin sialophosphoprotein were the lowest in the 3 cells. However, Western blot results showed that DFCs possessed more similar protein profiles to CNCCs than DPCs, including collagen 1, transforming growth factor beta 1, osteopontin, neurofilament, and dentin matrix protein 1. Meanwhile, DFCs as 1 source of dental stem cells possessed high potency in odontogenic differentiation in vitro. Moreover, similar dentinlike tissues were observed in all 3 groups in vivo.CNCCs, DFCs, and DPCs possessed different biological characteristics in odontogenic differentiation.",
        "keywords": [
            "cranial neural crest cells",
            "dental follicle cells",
            "dental pulp cells",
            "tooth development",
            "tooth regeneration"
        ],
        "authors": [
            {
                "name": "Chen Gang",
                "org": "State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China; National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China."
            },
            {
                "name": "Sun Qince",
                "org": "State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China; National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China."
            },
            {
                "name": "Xie Li",
                "org": "State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China; National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China."
            },
            {
                "name": "Jiang Zongting",
                "org": "State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China; National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China."
            },
            {
                "name": "Feng Lian",
                "org": "State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China; National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China."
            },
            {
                "name": "Yu Mei",
                "org": "State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China; National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China."
            },
            {
                "name": "Guo Weihua",
                "org": "State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China; National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China; Department of Pedodontics, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China."
            },
            {
                "name": "Tian Weidong",
                "org": "State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China; National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, People's Republic of China."
            }
        ],
        "venue": "Journal of endodontics",
        "year": 2015
    },
    "8Y3YmTk2": {
        "id": "8Y3YmTk2",
        "title": "Pluripotency potential of human adipose-derived stem cells marked with exogenous green fluorescent protein.",
        "abstract": "Musculoskeletal tissues regeneration requires rapid expansion of seeding cells both in vitro and in vivo while maintaining their multilineage differentiation ability. Human adipose-derived stem cells (ASCs) are considered to contain multipotent mesenchymal stem cells. Monolayer cultures of human ASCs were isolated from human lipoaspirates and passaged 3 times and then infected with replication-incompetent adenoviral vectors carrying green fluorescent protein (Ad/GFP) genes. Then, Ad/GFP infected human ASCs were transferred to osteogenic, chondrogenic, adipogenic, and myogenic medium. The morphological characterization of induced cells was observed using phase-contrast microscopy and fluorescence microscopy. The expression of marker proteins or genes was measured by immunocytochemical and RT-PCR analysis. Osteopontin (OPN), and osteocalcin (OCN) were positive in osteogenic lineages, aggrecan and SOX9 were positive in chondrogenic ones, peroxisome proliferator-activated receptor (PPAR-gamma2) and lipoprotein lipase (LPL) were positive in adipogenic ones, and myogenin and myod1 was positive in myogenic ones. At the same time, the results of fluorescence microscopic imaging proved that the high level of GFP expression during ASCs differentiation maintained stable nearly 2 months. So the exogenous GFP and multilineage potential of human ASCs had no severe influences on each other. Since the human ASCs can be easily obtained and abundant, it is proposed that they may be promising candidate cells for further studies on tissue engineering. Imaging with expression of GFP facilitates the research on ASCs physiological behavior and application in tissue engineering during differentiation both in vitro and in vivo.",
        "keywords": [
            "human adipose-derived stem cells",
            "green fluorescent protein",
            "pluripotency"
        ],
        "authors": [
            {
                "name": "Yunfeng Lin",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R. China Chengdu 610041 P.R. China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R. China Chengdu 610041 P.R. China"
            },
            {
                "name": "Zhiyong Li",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R. China Chengdu 610041 P.R. China"
            },
            {
                "name": "Ju Qiao",
                "org": "Sichuan University Department of Orthodontics, West China College of Stomatology Chengdu 610041 P.R. China Chengdu 610041 P.R. China"
            },
            {
                "name": "Ling Wu",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R. China Chengdu 610041 P.R. China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R. China Chengdu 610041 P.R. China"
            },
            {
                "name": "Xiaohui Zheng",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R. China Chengdu 610041 P.R. China"
            },
            {
                "name": "Xizhe Chen",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R. China Chengdu 610041 P.R. China"
            },
            {
                "name": "Zhengbin Yan",
                "org": "Sichuan University Department of Orthodontics, West China College of Stomatology Chengdu 610041 P.R. China Chengdu 610041 P.R. China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R. China Chengdu 610041 P.R. China"
            }
        ],
        "venue": "Molecular and cellular biochemistry",
        "year": 2006
    },
    "0vJYAiyT": {
        "id": "0vJYAiyT",
        "title": "Clinical application of individual digital reconstruction technology in cranio-maxillofacial deformities",
        "abstract": "BACKGROUND: Because of the complexity of skeleton anatomy relationship of cranio-maxillofacial region, traditional methods cannot exactly exhibit the characteristics of cranio-maxillofacial region deformities, and cannot simulate preoperative surgery. Digital model surgery technique can provide a real cranial phantom, reflect details of skull structure, and exactly solve some problems such as cranio-maxillofacial repair symmetry. OBJECTIVE: To explore clinical application effects of individual digital surgery in reconstruction and repair of cranio-maxillofacial complex deformities. METHODS: A total of seven patients with cranio-maxillofacial complex deformities were selected from West China Stomatology Hospital, Sichuan University between 2008 and 2009. CT scanner was employed to scan the patient heads and faces and to obtain three-dimensional data. Through the computer aid design combined with three-dimensional reconstruction, preoperative precise diagnosis of cranio-maxillofacial anomalies and surgery simulation design were successfully performed. Meanwhile, three-dimensional bionic cranium models and individual prosthesis could be fabricated with reverse engineering and rapid prototyping techniques, which resulted in the well restoration of complex deformity. RESULTS AND CONCLUSION: Based on computer aid design-computer aid manufacture technique, the individual digital surgery will significantly promote the accuracy in cranio-maxillofacial plastic surgery and increase the clinical therapy effects. What\u2019s more, it simplified the operative procedure, shorten operation time and decrease surgical risk. These suggested that individual digital surgery possesses high clinical practical value in reconstruction and repair of cranio-maxillofacial complex deformity.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Ou Fei",
                "org": "Department of Stomatology, Mianyang Municipal Third Hospital, Mianyang , Sichuan Province, China"
            },
            {
                "name": "Duan Shi-jun",
                "org": "Department of Oral and Maxillofacial Surgery, West China Stomatology Hospital, Sichuan University, Chengdu , Sichuan Province, China"
            },
            {
                "name": "Zhang Jin-ge",
                "org": "Department of Oral and Maxillofacial Surgery, West China Stomatology Hospital, Sichuan University, Chengdu , Sichuan Province, China"
            },
            {
                "name": "Gong Ha-ni",
                "org": "Department of Oral and Maxillofacial Surgery, West China Stomatology Hospital, Sichuan University, Chengdu , Sichuan Province, China"
            },
            {
                "name": "Tian Wei-dong",
                "org": "Department of Oral and Maxillofacial Surgery, West China Stomatology Hospital, Sichuan University, Chengdu , Sichuan Province, China"
            },
            {
                "name": "Tang Wei",
                "org": "Department of Oral and Maxillofacial Surgery, West China Stomatology Hospital, Sichuan University, Chengdu , Sichuan Province, China"
            }
        ],
        "venue": "Journal of Clinical Rehabilitative Tissue Engineering Research",
        "year": 2010
    },
    "a7qVZ4CT": {
        "id": "a7qVZ4CT",
        "title": "The potential of dental stem cells differentiating into neurogenic cell lineage after cultivation in different modes in vitro.",
        "abstract": "Trauma or degenerative diseases of the central nervous system (CNS) cause the loss of neurons or glial cells. Stem cell transplantation has become a vital strategy for CNS regeneration. It is necessary to effectively induce nonneurogenic stem cells to differentiate into neurogenic cell lineages because of the limited source of neurogenic stem cells, relatively difficult cultivation, and ethical issues. Previous studies have found that dental stem cells can be used for transplantation therapy. The aim of this study was to explore a better inductive mode and time point for dental stem cells to differentiate into neural-like cells and evaluate a better candidate cell. In this study, dental follicle stem cells (DFSCs), dental papilla stem cells (DPSCs), and stem cells from apical papilla (SCAPs) were cultivated in five different modes. The proliferation ability, morphology, and expression of neural marker genes were analyzed. Results showed that DFSCs showed a higher proliferation potential. The proliferation was decreased after cultivation in chemical inductive medium as cultivation modes 3 and 5. The cells could present neural-like cell morphology after cultivation with human epidermal growth factor (EGF) and fibroblast growth factor-basic (bFGF) as cultivation modes 4 and 5. The vast majority of DFSCs gene expression levels in mode 4 on the third day was upregulated significantly. In conclusion, our data suggested that different dental stem cells exhibited different neural differentiation potentials. DFSCs might be the better candidate cell type. Furthermore, cultivation mode 4 and timing of the third day may promote differentiation into neurogenic cell lineages more effectively before transplantation to treat neurological diseases.",
        "keywords": [],
        "authors": [
            {
                "name": "Chao Yang",
                "org": "1 National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University , Chengdu, 610041, China ."
            },
            {
                "name": "Liang Sun",
                "org": ""
            },
            {
                "name": "Xinghan Li",
                "org": ""
            },
            {
                "name": "Li Xie",
                "org": ""
            },
            {
                "name": "Mei Yu",
                "org": ""
            },
            {
                "name": "Lian Feng",
                "org": ""
            },
            {
                "name": "Zongting Jiang",
                "org": ""
            },
            {
                "name": "Weihua Guo",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Cellular reprogramming",
        "year": 2014
    },
    "uXZdxJYn": {
        "id": "uXZdxJYn",
        "title": "Expression of Pcp4 gene during osteogenic differentiation of bone marrow mesenchymal stem cells in\u00a0vitro",
        "abstract": "In this study, we established an in\u00a0vitro model of osteogenic-inductive differentiation of rat bone marrow mesenchymal stem\n cells (BMSCs) to determine the mechanisms and relative gene function underlying BMSCs osteogenesis. Osteoplastic differentiation\n of the third generation BMSCs was induced with the \u03b1-minimal essential medium containing \u03b2-glyceraldehyde-3-phosphate, l-ascorbic acid, dexamethasone and 1,25\u20132(OH)2 vitamin D3 prior to applying gene chip technology (also called microarray technology) for global gene expression screening. Real-time\n quantitative PCR (Real-time PCR) was used to determine the temporal profile of mRNA expression of regulated genes during osteogenic\n differentiation of BMSCs. A bioinformatic analysis was utilized to determine the functional significance of the identified\n osteogenic-related genes. Purkinje cell protein 4 (Pcp4) mRNA expression was identified by the gene chip screening as being\n up-regulated during osteoplastic differentiation of BMSCs. Real-time PCR analysis confirmed the increased expression of Pcp4\n mRNA expression during osteoplastic differentiation of BMSCs with an upward trend that peaked at day 14. The bioinformatic\n analysis identified Pcp4 as a gene involved in the deposition of calcium and the modulation of CaM-dependent protein kinase.\n Thus, we hypothesize that Pcp4 osteoplastic differentiation of BMSCs is mediated in part via Pcp4-induced calcium deposition\n to form mineral nodules and modulation of certain signal transduction pathways of BMPs.",
        "keywords": [
            "Bone marrow mesenchymal stem cells",
            "Osteogenic differentiation",
            "Gene chip",
            "Real-time quantitative PCR"
        ],
        "authors": [
            {
                "name": "Jingang Xiao",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R. China"
            },
            {
                "name": "Yao Wu",
                "org": "State Key Laboratory of Stomatology Chengdu 610044 P.R. China"
            },
            {
                "name": "Runliang Chen",
                "org": "Tianjin First People\u2019s Hospital Tianjin 300192 P.R. China"
            },
            {
                "name": "Yunfeng Lin",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R. China"
            },
            {
                "name": "Ling Wu",
                "org": "State Key Laboratory of Stomatology Chengdu 610044 P.R. China"
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Stomatology Chengdu 610044 P.R. China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R. China"
            }
        ],
        "venue": "Molecular and Cellular Biochemistry",
        "year": 2008
    },
    "sYo6pasF": {
        "id": "sYo6pasF",
        "title": "Cytoskeletal Binding Proteins Distinguish Cultured Dental Follicle Cells and Periodontal Ligament Cells.",
        "abstract": "Human dental follicle cells (DFCs) and periodontal ligament cells (PDLCs) derived from the ectomesenchymal tissue, have been shown to exhibit stem/progenitor cell properties and the ability to induce tissue regeneration. Stem cells in dental follicle differentiate into cementoblasts, periodontal ligament fibroblasts and osteoblasts, these cells form cementum, periodontal ligament and alveolar bone, respectively. While stem cells in dental follicle are a precursor to periodontal ligament fibroblasts, the molecular changes that distinguish cultured DFCs from PDLCs are still unknown. In this study, we have compared the immunophenotypic features and cell cycle status of the two cell lines. The results suggest that DFCs and PDLCs displayed similar features related to immunophenotype and cell cycle. Then we employed an isobaric tag for relative and absolute quantitation (iTRAQ) proteomics strategy to reveal the molecular differences between the two cell types. A total of 2,138 proteins were identified and 39 of these proteins were consistently differentially expressed between DFCs and PDLCs. Gene ontology analyses revealed that the protein subsets expressed higher in PDLCs were related to actin binding, cytoskeletal protein binding, and structural constituent of muscle. Upon validation by real-time PCR, western blotting, and immunofluorescence staining. Tropomyosin 1 (TPM1) and caldesmon 1 (CALD1) were expressed higher in PDLCs than in DFCs. Our results suggested that PDLCs display enhanced actin cytoskeletal dynamics relative to DFCs while DFCs may exhibit a more robust antioxidant defense ability relative to PDLCs. This study expands our knowledge of the cultured DFCs and PDLCs proteome and provides new insights into possible mechanisms responsible for the different biological features observed in each cell type.",
        "keywords": [
            "Cytoskeleton",
            "Periodontium",
            "Proteome",
            "Stem cells",
            "Tissue regeneration"
        ],
        "authors": [
            {
                "name": "Jie Li",
                "org": "College of Life Science, Sichuan University, Chengdu, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Hui Li",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Ye Tian",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Yaling Yang",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Guoqing Chen",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weihua Guo",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Pedodontics, West China School of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weidong Tian",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, China."
            }
        ],
        "venue": "Experimental cell research",
        "year": 2015
    },
    "DLsQkX5V": {
        "id": "DLsQkX5V",
        "title": "Optimal design of an individual endoprosthesis for the reconstruction of extensive mandibular defects with finite element analysis.",
        "abstract": "The aim of this study was to evaluate the finite element analysis (FEA) approach to assess biomechanical performance of individual endoprostheses used in the reconstruction of extensive mandibular defects, and to explore an available strategy for the optimal design of prostheses.A female patient experienced fracture of a titanium mandibular endoprosthesis one year after reconstructive surgery. The endoprosthesis was placed during resection of a mandibular carcinoma. Using CT data, a finite element analysis (FEA) of the implant was performed to identify potential causes for this mechanical failure. Based on the first FEA analysis, modifications of the prosthesis geometry and screw configuration were carried out. FEA was performed for each subsequent modification until no stress concentration areas were identified. The final version of the titanium prosthesis was implanted during the second mandibular reconstruction.The FEA model was constructed, based on the geometrical data of the patient. Two areas of stress concentration were identified in the original prosthesis: - at the top surface of the left stem, 1.5 cm away from the corner (the peak stress was 616 MPa) and - on the exterior surface of the right stem, close to the mandibular stump margin. The mechanical failure occurred at the top surface of the left stem. Some common characteristics of the biomechanical performance were noted in the two models, but lower overall stress was achieved in the second, optimized prosthesis. By thickening the recognized high stress areas, and attenuating those areas subject to less stress, then adopting a quadrilateral screw configuration, this dispersed the stress more evenly in the optimized endoprosthesis. Function in the optimized reconstructed mandible was observed for 3 years without significant endoprosthesis related complication.In some patients with extensive mandibular defects, the individually tailored endoprosthesis constructed with regard to minimizing stress concentration using this method seems to have a place. The prosthesis geometry and screw configuration influence the stress-strain distribution on the reconstructed mandible. Our FEA approach can optimize the design of individual endoprostheses and give the reconstructed mandible improved biomechanical performance.",
        "keywords": [
            "mandibular reconstruction",
            "finite element analysis",
            "individual endoprosthesis",
            "optimal design"
        ],
        "authors": [
            {
                "name": "Peng Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Longduo Shen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jia Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Rui Liang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery",
        "year": 2014
    },
    "Hxb1Knc1": {
        "id": "Hxb1Knc1",
        "title": "Osteogenic differentiation of adipose derived stem cells promoted by overexpression of osterix.",
        "abstract": "Adipose-derived stem cells (ASCs) are considered to be multipotent mesenchymal stem cells that are easily induced to differentiate into functional osteoblasts both in vitro and in vivo. Osterix (Osx) is a zinc finger-containing transcription factor of Sp gene family, which plays important roles in bone development and mineralization. In this study, we hypothesized that overexpression of Osx in murine ASCs would promote their osteogenic differentiation in vitro. A plasmid expressing Osx (pcDNA3.1-Osx) was constructed and applied to transfect monolayers of murine ASCs. Then expression of bone-related genes, nodule formation, proliferation rate, and alkaline phosphatase activity were examined to evaluate the osteogenic potential of ASCs with pcDNA3.1-Osx transfection. Results of RT-PCR and immunohistochemistry showed that pcDNA3.1-Osx transfection enhanced the expression of bone matrix proteins, such as bone sialoprotein, osteocalcin, osteopontin, and Collagen type I in ASCs. At the same time, overexpression of Osx in ASCs enhanced alkaline phosphatase activity and capability to form mineralized nodules, while not inhibited their proliferation rate. These results indicated that pcDNA3.1-Osx transfection promoted the osteogenic differentiation of ASCs, while not affecting their proliferative ability. Since they can be easily isolated and genetically modified, ASCs are hopeful cell sources in the further application of hard tissue engineering.",
        "keywords": [
            "Adipose derived stem cells",
            "Osterix",
            "Osteogenic differentiation",
            "Osteoblasts",
            "Overexpression"
        ],
        "authors": [
            {
                "name": "Ling Wu",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R. China"
            },
            {
                "name": "Yao Wu",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R. China"
            },
            {
                "name": "Yunfeng Lin",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R. China"
            },
            {
                "name": "Wei Jing",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R. China"
            },
            {
                "name": "Xin Nie",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R. China"
            },
            {
                "name": "Ju Qiao",
                "org": "Sichuan University Department of Othodontics, West China College of Stomatology Chengdu 610041 P.R. China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R. China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R. China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R. China"
            }
        ],
        "venue": "Molecular and cellular biochemistry",
        "year": 2007
    },
    "kc3Foo2e": {
        "id": "kc3Foo2e",
        "title": "Secretory factors from rat adipose tissue explants promote adipogenesis and angiogenesis.",
        "abstract": "Adipogenic differentiation of adipose-derived stem cells (ASCs) is known to be affected by many promoting and inhibiting factors, and correlated with surrounding cells and extracellular matrix. However, few studies have evaluated the effect of secreted biological molecules from adipose tissue explants on the growth of ASCs. In this study, ASCs were isolated and the secretory factors from adipose tissue explants (SFAE) were prepared from adipose tissue explants. The multilineage differentiation potential of ASCs was determined using different inductive media. The influence of SFAE on the colony formation and proliferation of ASCs was determined using colony-forming efficiency assay and Cell Counting Kit-8 assay, respectively. Real-time polymerase chain reaction and Western blot were performed to analyze the beneficial effect of SFAE on the adipogenesis and angiogenesis of ASCs. Utilizing gelatin scaffold, the influence of SFAE on ASCs was investigated in vivo. Subsequently, cell/gelatin constructs were cultured in a subcutaneous pocket on a rat dorsum for 2 and 9 weeks, and the resultant samples were histologically evaluated. Results showed that ASCs derived from adipose explants can differentiate along multiple lineages in vitro. Utilizing SFAE, the proliferation and colony-forming efficiency of ASCs were inhibited, while the expression of adipogenesis markers such as C/EBP\u03b2, PPAR\u03b32, and LPL, as well as angiogenesis factor VEGF-A were promoted. Moreover, the beneficial effect of SFAE on adipogenesis was revealed in vivo. In conclusion, our results suggested that SFAE has beneficial influence on adipogenesis and angiogenesis both in vitro and in vivo.",
        "keywords": [
            "angiogenesis",
            "adipose tissue engineering",
            "secretory factors from adipose tissue explants",
            "adipogenesis",
            "stem cells"
        ],
        "authors": [
            {
                "name": "Jie Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xiangchen Qiao",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Mei Yu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Feng Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Hang Wang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weihua Guo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Artificial organs",
        "year": 2014
    },
    "NmVkyINh": {
        "id": "NmVkyINh",
        "title": "Expression of miR-31, miR-125b-5p, and miR-326 in the adipogenic differentiation process of adipose-derived stem cells.",
        "abstract": "MicroRNAs (miRNAs) are small single-stranded RNAs of 19-22 nucleotides (nt) and are important posttranscriptional regulation of genes. A link between miRNA function and cancer was researched by the miRNAs microarray technology recently. However, during adipogenic differentiation of ADSCs process, this technology was less used to study adipogenic differentiation mechanism of ADSCs. In this study, miRNA microarray technology was used to examine the expression of miRNA that were differences between induced group and noninduced group of ADSC adipogenic differentiation. Real-time quantitative PCR (real-time qPCR) was used to quantify the miRNA expression. The TargetScan 5.0 software was used to find their target genes. Our results showed that the expression of rno-miR-31, rno-miR-125b-5p, and rno-miR-326 were downregulation in the adipogenic differentiation process. By the statistic analysis, this study showed that the expression of rno-miR-31 and rno-miR-326 were significantly deregulation. In addition, the target genes of rno-miR-31 and rno-miR-326 were correlated with the adipogenic differentiation. Our study suggested that the expression of rno-miR-31 and rno-miR-326 were involved in the adipogenic differentiation process.",
        "keywords": [
            "stem cell"
        ],
        "authors": [
            {
                "name": "Yan-Feng Tang",
                "org": ""
            },
            {
                "name": "Yong Zhang",
                "org": ""
            },
            {
                "name": "Xiao-Yu Li",
                "org": ""
            },
            {
                "name": "Cai Li",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            }
        ],
        "venue": "Omics : a journal of integrative biology",
        "year": 2009
    },
    "u8rpEYx4": {
        "id": "u8rpEYx4",
        "title": "Study on mRNA expression of fibronectin and integrin beta1 during fracture healing]",
        "abstract": "To investigate the spatial and temporal expression changes of fibronectin and integrin beta1 mRNA during fracture healing.Using in situ RT-PCR technique, the spatial and temporal expression pattern of both fibronectin and integrin beta1 mRNA was detected on paraffined slices in different rabbit mandibular fracture healing phases.(1) The mRNA of integrin beta1 and fibronectin was widely expressed in fractured bone cells. The positive stain existed in cytoplasm and nucleolus. (2) After 7 days of fracture, increaseded integrin beta1 mRNA expression was observed, and it reached maximal levels approximately 14- 30 days post-fracture and returned to normal levels after 60 - 90 days. (3) Fibronectin mRNA was detected on 3 days post-fracture, it reached maximal levels at 7 - 14 days, faint expression was detected at 30 days, undetectable 60 days afterwards.During fracture healing, the mRNA expression of integrin beta1 and fibronectin increased locally, FN and Itg beta1 cooperate with each other, it is suggested that they have an important influence on fracture healing.",
        "keywords": [],
        "authors": [
            {
                "name": "Shao-hua Liu",
                "org": "Dept. of Oral and Maxillofacial Surgery, Qilu Hospital of Shandong University, Jinan 250012, China."
            },
            {
                "name": "Gang Cheng",
                "org": ""
            },
            {
                "name": "Sheng-wei Li",
                "org": ""
            },
            {
                "name": "Wei-dong Tian",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2005
    },
    "8gLOcKEf": {
        "id": "8gLOcKEf",
        "title": "\u03b2-transduction Repeat Containing Protein Expressed in Tooth Germs and Ameloblast and Odontoblast of Different Stage of Tooth Development",
        "abstract": "Objective The Sonic hedgehog signalling peptide has been demonstrated to play important roles in the growth and patterning of the tooth development.This study aims on whether the antagonist \u03b2-transduction repeat containing protein of Sonic hedgehog signal transduction expressed in tooth germs ameloblast and odontoblast or not.Methods The mouse embryo heads of different developmental stages of E10.5,E13.5,E14.5,E16.5,E18.5 and P0,P3,P6 after birth were acquired fixed with 4% paraformaldehyde for 48 hours,embeded with Paraffin and ex-amined using LsAB(labelled streptavidin-biotin) method to observe the \u03b2-TrCP expression pattern in tooth germs,ameloblast and odontoblast.Results It was demonstrated that \u03b2-TrCP expressed in oral epithelium,tooth bud,mesenchymal cell cytoplasm of ameloblast and odontoblast of different stage of tooth development.Conclusion \u03b2-TrCP expressed from early stage to later stage of murine tooth development.And these findings provide the evidence of antagonist regulatory pathways for shh in teeth development.",
        "keywords": [
            "ameloblast",
            "odontoblast",
            "tooth germs"
        ],
        "authors": [
            {
                "name": "SHEN Yong-dai",
                "org": "Key.Laboratory of Oral Biomedical Engineering of Ministry of Education,Sichuan University,Chengdu ,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "Key.Laboratory of Oral Biomedical Engineering of Ministry of Education,Sichuan University,Chengdu ,China"
            },
            {
                "name": "LIU Lei",
                "org": "Key.Laboratory of Oral Biomedical Engineering of Ministry of Education,Sichuan University,Chengdu ,China"
            },
            {
                "name": "HE Yong-hong",
                "org": "Key.Laboratory of Oral Biomedical Engineering of Ministry of Education,Sichuan University,Chengdu ,China"
            },
            {
                "name": "TANG Wei",
                "org": "Key.Laboratory of Oral Biomedical Engineering of Ministry of Education,Sichuan University,Chengdu ,China"
            },
            {
                "name": "ZHENG Xiao-hui",
                "org": "Key.Laboratory of Oral Biomedical Engineering of Ministry of Education,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "West China Journal of Stomatology",
        "year": 2007
    },
    "5OTTG8j1": {
        "id": "5OTTG8j1",
        "title": "Physiological and pathological impact of exosomes of adipose tissue.",
        "abstract": "Exosomes are nanovesicles that have emerged as a new intercellular communication system for transporting proteins and RNAs; recent studies have shown that they play a role in many physiological and pathological processes such as immune regulation, cell differentiation, infection and cancer. By transferring proteins, mRNAs and microRNAs, exosomes act as information vehicles that alter the behavior of recipient cells. Compared to direct cell-cell contact or secreted factors, exosomes can affect recipient cells in more efficient ways. In whole adipose tissues, it has been shown that exosomes exist in supernatants of adipocytes and adipose stromal cells (ADSCs). Adipocyte exosomes are linked to lipid metabolism and obesity-related insulin resistance and exosomes secreted by ADSCs are involved in angiogenesis, immunomodulation and tumor development. This review introduces characteristics of exosomes in adipose tissue, summarizes their functions in different physiological and pathological processes and provides the further insight into potential application of exosomes to disease diagnosis and treatment.",
        "keywords": [],
        "authors": [
            {
                "name": "Yan Zhang",
                "org": "State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Mei Yu",
                "org": "State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu, China."
            }
        ],
        "venue": "Cell proliferation",
        "year": 2016
    },
    "m3r9Fs5t": {
        "id": "m3r9Fs5t",
        "title": "Application of Intraoperative Navigation for the Reconstruction of Mandibular Defects With Microvascular Fibular Flaps-Preliminary Clinical Experiences.",
        "abstract": "A microvascular fibular flap is the main option for the reconstruction of mandibular defects. This paper introduces an innovative strategy for the accurate fabrication of fibular flaps.Nine patients with mandibular tumors were included in this study. The mandibular reconstruction planning was performed using MIMICS 10.01. One reconstruction plate was preformed. During the operation, the fibular flap was fabricated and implanted using the BrainLab navigation system. Six to 12 months after surgery, computed tomography data were acquired and compared with preoperative planning.The osteotomy of the fibular flap and the mandible was easily performed, using the navigation and the osteotomy template respectively. The preformed plate accurately determined the position of the flap. The treatment outcome was consistent with the preoperative planning using 3D analysis.Combination of the intraoperative navigation and preformed plate technique demonstrated great practical value in mandibular reconstruction with microvascular fibular flaps.",
        "keywords": "",
        "authors": [
            {
                "name": "Peng Li",
                "org": "*Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University \u2020Department of Oral and Maxillofacial Surgery, Sichuan Provincial People's Hospital, Chengdu, China."
            },
            {
                "name": "Ming Xuan",
                "org": ""
            },
            {
                "name": "Chuhang Liao",
                "org": "*Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University \u2020Department of Oral and Maxillofacial Surgery, Sichuan Provincial People's Hospital, Chengdu, China."
            },
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Xiao-Yi Wang",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Jie Long",
                "org": ""
            }
        ],
        "venue": "The Journal of craniofacial surgery",
        "year": 2016
    },
    "Phykxg1l": {
        "id": "Phykxg1l",
        "title": "Outcome of postsurgical sequential functional exercise of jaw fracture.",
        "abstract": "A large number of studies and clinical cases show that an ideal prognosis for mouth function cannot be obtained without sufficient and reasonable postsurgical functional exercise after jaw fracture. However, no unifying criteria exist on postsurgical functional exercise with jaw fracture. The study was designed to explore effective methods of postsurgical functional exercise of jaw fracture.One hundred seventeen inpatients with jaw fracture between August 2005 and August 2006 were subjects in this study. Sequential function exercise methods were used to recover patients' gape degree, chewing, and so on. Gape degree was recorded, and healing of the jaw was assessed using x-ray.All 117 patients with jaw fracture who underwent surgery were involved in the analysis. After sequential function exercise, gape degree and chewing function improved; good occluding relations were retained. Gape degree was significantly improved at 8 or 12 weeks postsurgery compared with 1 or 4 weeks postsurgery (P < 0.01). However, no significant differences in gape degree were observed between 1 and 4 weeks postsurgery and between 8 and 12 weeks postsurgery (P > 0.05).Sequential function exercise contributes much to patient recovery of mouth function. This method is effective for postsurgical functional recovery of jaw fracture.",
        "keywords": [
            "functional exercise",
            "gape degree",
            "jaw fracture",
            "occluding relation"
        ],
        "authors": [
            {
                "name": "Zhiyuan Feng",
                "org": ""
            },
            {
                "name": "Runliang Chen",
                "org": ""
            },
            {
                "name": "Yong Zhang",
                "org": ""
            },
            {
                "name": "Miaomiao Yang",
                "org": ""
            },
            {
                "name": "Yunfeng Lin",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            }
        ],
        "venue": "The Journal of craniofacial surgery",
        "year": 2009
    },
    "YM5lZgxc": {
        "id": "YM5lZgxc",
        "title": "Construction of recombinant adenovirus vector carrying the mouse dentin sialophosphoprotein gene",
        "abstract": "Objective To construct recombinant adenoviral vector carrying the mouse dentin sialophosphoprotein gene using the recombinant adenoviral vector system AdEasy.Methods The cDNA fragment of DSPP was derived from pTRE2-DSPP by restriction enzyme and subcloned into shuttle plasmid pAdtrack-CMV. The resultant plasmid pAdtrack-CMV-DSPP, after linearized by digesting with restriction endonuclease Pme I , was transformed into E. coli. BJ5183 which had been transformed by adenoviral backbone plasmid pAdEasy-1. The recombinant plasmid pAd-DSPP was screened by alternation of kanamycin and then identified by restriction enzyme. The linearized adenovirus plasmid pAd-DSPP was packaged in 293 cells, then Ad-DSPP was harvested. The expression of green fluorescence protein was observed under fluorescent microscope. With further amplification and purification, the titer of adenovirus was determined.Results The recombinant adenovirus was identified by restriction enzyme digestion analysis and gene sequencing. Negative colony and cytopathic effect emerged in the infected 293 cells. The expression of GFP was observed and the titer was 2\u00d710~9 pfu/ml. Conclusion The mouse DSPP recombinant adenovirus vector can be constructed successfully using AdEasy system. Cell transfection and expression of exogenous gene can be detected directly by observing the expression of GFP. These results provide the basis for further study on the role of DSPP gene in dental development.",
        "keywords": [
            "Homologous recombination",
            "Green fluorescent protein",
            "Dentin sialophosphoprotein",
            "Adenovirus vector"
        ],
        "authors": [
            {
                "name": "ZHU Feng",
                "org": ".Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu ,China"
            },
            {
                "name": "NIE Rong-rong",
                "org": ".Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu ,China"
            },
            {
                "name": "LIU Lei",
                "org": ".Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu ,China"
            },
            {
                "name": "TANG Wei",
                "org": ".Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu ,China"
            },
            {
                "name": "ZHENG Xiao-hui",
                "org": ".Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu ,China"
            },
            {
                "name": "WU Ling",
                "org": ".Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu ,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": ".Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu ,China"
            }
        ],
        "venue": "Beijing Journal of Stomatology",
        "year": 2007
    },
    "ztm5HnwM": {
        "id": "ztm5HnwM",
        "title": "Research progress on microvascular angiogenesis in autologous fat graft",
        "abstract": "Soft tissue defects resulted from a variety of reasons not only lead to appearance disfigurement,but also seriously affect emotional well-being of patients,and is one of the most significant challenges in reconstructive and plastic surgery.Autologous fat graft has been popular in repair of soft tissue defects because of its rich material resources,convenience in obtaining,no immunity reaction and so on.But its unstability and significant resorption over time has greatly restricted its wider utilization in patients.The main problem is insufficient blood supply in fat grafts.So more and more researches focus on how to improve microvascular angiogenesis and fat graft viability.Here we review recent studies that revealed the microvascular angiogenesis in autologous fat graft.",
        "keywords": [
            "viability",
            "soft tissue defect",
            "angiogenesis",
            "autologous fat graft"
        ],
        "authors": [
            {
                "name": "Li Feng",
                "org": ""
            },
            {
                "name": "Jing Wei",
                "org": ""
            },
            {
                "name": "Tian Weidong",
                "org": ""
            }
        ],
        "venue": "International Journal of Stomatology",
        "year": 2012
    },
    "5PV2nxjZ": {
        "id": "5PV2nxjZ",
        "title": "A new coronal scalp technique to treat craniofacial fracture: the supratemporalis approach.",
        "abstract": "A new coronal scalp approach, denoted as the supratemporalis approach, was designed to address facial nerve injury induced by the traditional coronal scalp approach.First, the complication rate among 38 cases operated upon with the traditional coronal scalp approach was analyzed retrospectively. Then 40 cases were operated upon using the supratemporalis approach. The rate of complications was recorded. The follow-up periods were 3-17 months.The facial contours and functions recovered well after the operation in all 78 cases. Seven cases of facial nerve injury, 1 of which was permanent, were observed in the group treated with the traditional coronal scalp approach. No case of facial nerve injury was observed in the group treated with the supratemporalis approach.The supratemporalis approach prevented facial nerve injury and did not increase the frequency of other complications. It is therefore worthy of application in the clinical setting.",
        "keywords": [],
        "authors": [
            {
                "name": "Wen Luo",
                "org": "Resident, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Li Wang",
                "org": "Resident, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Wei Jing",
                "org": "Attending Surgeon, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Xiaohui Zheng",
                "org": "Associate Professor, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Jie Long",
                "org": "Associate Professor, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Weidong Tian",
                "org": "Professor, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Lei Liu",
                "org": ""
            }
        ],
        "venue": "Oral surgery, oral medicine, oral pathology and oral radiology",
        "year": 2012
    },
    "SRg9odIR": {
        "id": "SRg9odIR",
        "title": "Molecular and cellular characterization during chondrogenic differentiation of adipose tissue-derived stromal cells in vitro and cartilage formation in vivo",
        "abstract": "",
        "keywords": [
            "stromal cells",
            "adipose tissue"
        ],
        "authors": [
            {
                "name": "yunfeng lin",
                "org": "sichuan university"
            },
            {
                "name": "en luo",
                "org": "sichuan university"
            },
            {
                "name": "xizhe chen",
                "org": "sichuan university"
            },
            {
                "name": "lei liu",
                "org": "sichuan university"
            },
            {
                "name": "ju qiao",
                "org": "sichuan university"
            },
            {
                "name": "zhengbin yan",
                "org": "sichuan university"
            },
            {
                "name": "zhiyong li",
                "org": "sichuan university"
            },
            {
                "name": "wei tang",
                "org": "sichuan university"
            },
            {
                "name": "xiaohui zheng",
                "org": "sichuan university"
            },
            {
                "name": "weidong tian",
                "org": "sichuan university"
            }
        ],
        "venue": "Cell Research",
        "year": 2008
    },
    "5PLepuOG": {
        "id": "5PLepuOG",
        "title": "Application and prospect of internal fixation of maxillofacial fractures",
        "abstract": "Following the successful experiences with rigid internal fixation of the craniomaxillofacial region,instrumentation and hardware have been developed to allow stable internal fixation by AO/ASIF. With the development of lighter and more biocompatible implants,the concepts of internal fixation has evolved from the \"rigid or absolutely stable internal fixation\" to a \"functionally stable internal fixation\". The systematic and sequential choices of surgical methods are key factors in determining fracture treatment outcomes. We propose that treatment of bone fractures take into account the biological characteristics of the damaged bone to facilitate selection of appropriate plate and screw systems and repositioning methods.",
        "keywords": [
            "fractures",
            "maxillofacial",
            "BO principles",
            "AO technique"
        ],
        "authors": [
            {
                "name": "TANG Wei",
                "org": ". Department of Oral and Maxillofacial Surgery,West China College of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": ". Department of Oral and Maxillofacial Surgery,West China College of Stomatology,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Chinese Journal of Practical Stomatology",
        "year": 2010
    },
    "OerJolEA": {
        "id": "OerJolEA",
        "title": "Analysis of maxillofacial injuries caused by the 2010 Yushu earthquake in China.",
        "abstract": "The condition of maxillofacial injuries after a major earthquake is not well understood because of limited data. The purpose of this study was to describe the maxillofacial injuries caused by the 2010 Yushu earthquake in China.A total of 126 patients treated for seismic-related injuries at hospitals in the Chengdu area were investigated. Of the 126 patients, 46 (36.5%) had maxillofacial injuries. Gender, age, nationality and injury condition were recorded by talking with the patients and their families. The data were analysed using Microsoft Access 2003 and SPSS software programs.For the 46 patients, the female to male ratio was 1.3:1 and the mean age was 36.7 years. Most patients (41, 89.1%) were Tibetan. The most frequent cause of maxillofacial injury was pressing/burying (34 patients, 73.9%). All patients with maxillofacial injuries sustained soft-tissue injuries, 13.0% had facial fractures and 4.3% had dentoalveolar injuries. The soft-tissue injuries were largely combined injuries; 84.8% were bruises and 80.4% were lacerations. The most common injury site was the zygomatic region (54.3%), followed by the forehead (43.5%) and the orbital region (34.8%). Of the six facial fractures, four involved nasal-orbital-ethmoidal region fractures. Most of the maxillofacial injuries (78.3%) were associated with other injuries, of which extremity injuries (55.6%) were the most common.An analysis of the maxillofacial injuries sustained during the Yushu earthquake revealed some of the features of seismic-related maxillofacial injuries. The results from this study may help physicians provide better medical services during future disasters.",
        "keywords": [
            "suicide prevention",
            "occupational safety",
            "ergonomics",
            "human factors",
            "injury prevention"
        ],
        "authors": [
            {
                "name": "Lijuan Guo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weihua Guo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Rui Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Sheng",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Bo Yang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Jing",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Hang Wang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Emergency medicine journal : EMJ",
        "year": 2012
    },
    "ywodp6c4": {
        "id": "ywodp6c4",
        "title": "Finite element analysis of three zygomatic implant techniques for the severely atrophic edentulous maxilla.",
        "abstract": "A variety of zygomatic implantation techniques currently exist; however, a consensus regarding the most suitable method has not yet been reached.The purpose of this study was to evaluate and compare 3 zygomatic implantation techniques and to clarify the optimal number and position of zygomatic and dental implants for the reconstruction of the severely atrophied edentulous maxilla.A 3-dimensional finite element analysis craniofacial model was constructed from the computed tomography data of a selected patient with a severely atrophic edentulous maxilla. Modeled zygomatic implants were inserted into the craniofacial model with 3 surgical techniques (classic Br\u00e5nemark, exteriorized, and extramaxillary), and with 3 model variations that involved the number and position of zygomatic and dental implants. The zygomatic implants were loaded with a vertical force of 150 N and a lateral force of 50 N. The stresses on and deformations of the bones and implants were then observed and compared.No obvious differences in the amount and distribution of stress on the external craniofacial bones were detected in the models. The lowest stresses on the zygomatic implants were observed in the exteriorized technique group. The lowest deformations of the bone that surrounds zygomatic implants and dental implants were observed in the exteriorized technique and classic Br\u00e5nemark technique groups. For the exteriorized technique group, the model with 1 dental implant in the site of the maxillary lateral incisor exhibited the lowest stress on the zygomatic implants and the least deformation of the bone surrounding the zygomatic and dental implants.All 3 zygomatic implant techniques resulted in more or less homogeneous transference of force and thus could reconstruct the edentulous maxilla; however, the exteriorized technique with 1 dental implant in the lateral incisor appeared to be the most appropriate reconstruction method for the severely atrophied edentulous maxilla.",
        "keywords": [],
        "authors": [
            {
                "name": "Hailin Wen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weihua Guo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Rui Liang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lin Xiang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Gang Long",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Tingting Wang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Meng Deng",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "The Journal of prosthetic dentistry",
        "year": 2014
    },
    "MtckOZ7j": {
        "id": "MtckOZ7j",
        "title": "Inhibition of Ape1 Redox Activity Promotes Odonto/osteogenic Differentiation of Dental Papilla Cells.",
        "abstract": "Dentinogenesis is the formation of dentin, a substance that forms the majority of teeth, and this process is performed by odontoblasts. Dental papilla cells (DPCs), as the progenitor cells of odontoblasts, undergo the odontogenic differentiation regulated by multiple cytokines and paracrine signal molecules. Ape1 is a perfect paradigm of the function complexity of a biological macromolecule with two major functional regions for DNA repair and redox regulation, respectively. To date, it remains unclear whether Ape1 can regulate the dentinogenesis in DPCs. In the present study, we firstly examed the spatio-temporal expression of Ape1 during tooth germ developmental process, and found the Ape1 expression was initially high and then gradually reduced along with the tooth development. Secondly, the osteo/odontogenic differentiation capacity of DPCs was up-regulated when treated with either Ape1-shRNA or E3330 (a specific inhibitor of the Ape1 redox function), respectively. Moreover, we found that the canonical Wnt signaling pathway was activated in this process, and E3330 reinforced-osteo/odontogenic differentiation capacity was suppressed by Dickkopf1 (DKK1), a potent antagonist of canonical Wnt signaling pathway. Taken together, we for the first time showed that inhibition of Ape1 redox regulation could promote the osteo/odontogenic differentiation capacity of DPCs via canonical Wnt signaling pathway.",
        "keywords": [],
        "authors": [
            {
                "name": "Tian Chen",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China."
            },
            {
                "name": "Zhi Liu",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China."
            },
            {
                "name": "Wenhua Sun",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China."
            },
            {
                "name": "Jingyu Li",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China."
            },
            {
                "name": "Yan Liang",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China."
            },
            {
                "name": "Xianrui Yang",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China."
            },
            {
                "name": "Yang Xu",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China."
            },
            {
                "name": "Mei Yu",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China."
            },
            {
                "name": "Weidong Tian",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China."
            },
            {
                "name": "Guoqing Chen",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China."
            },
            {
                "name": "Ding Bai",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R. China."
            }
        ],
        "venue": "Scientific reports",
        "year": 2015
    },
    "1Vk4oKDy": {
        "id": "1Vk4oKDy",
        "title": "Hemiarthroplasty of the shoulder joint using a custom-designed high-density nano-hydroxyapatite/polyamide prosthesis with a polyvinyl alcohol hydrogel humeral head surface in rabbits.",
        "abstract": "In this study, a novel custom-designed high-density nano-hydroxyapatite/polyamide (n-HA/PA) prosthesis with a polyvinyl alcohol (PVA) hydrogel humeral head surface was employed to repair the shoulder joint head for hemiarthroplasty in rabbits. The prosthesis was fabricated using three-dimensional computed tomography and computer-aided design and computer-aided manufacturing systems for perfect fitting. Sixteen New Zealand white rabbits underwent humeral head excision, and received the composite prostheses for hemiarthroplasty. The implant sites were free from suppuration and necrosis at all periods. The X-ray results showed that there was a clear space between the prosthesis head and the glenoid surface, and the joint capsules and surfaces of the glenoid and PVA were well preserved without any damage during the whole inspection period. A high density of bone was observed around the firmware part of the prosthesis. Histological results revealed that significant osteogenesis was surrounding the firmware part, and the joint space was clear and the cartilage of the upper joint surface was basically intact. There was no visible absorption of the joint surfaces even after 3 months of continuous functional motions. The maximum tensile strength between the prosthesis and host bone reached 2.63\u2009MPa at the 12th week postimplantation. In conclusion, the customized prosthesis by combination of PVA and high-density n-HA/PA has excellent biocompatibility and biological fixation, and offers a promising substitute for both the cartilage and the bone of the humeral head in a rabbit model as level V evidence.",
        "keywords": [
            "custom-designed prosthesis",
            "nano-hydroxyapatite/polyamide",
            "polyvinyl alcohol hydrogel",
            "shoulder hemiarthroplasty",
            "synovial joint"
        ],
        "authors": [
            {
                "name": "Yongwen Guo",
                "org": "State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China; Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Jun Guo",
                "org": ""
            },
            {
                "name": "Ding Bai",
                "org": ""
            },
            {
                "name": "Hang Wang",
                "org": ""
            },
            {
                "name": "Xiaohui Zheng",
                "org": ""
            },
            {
                "name": "Weihua Guo",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Artificial organs",
        "year": 2014
    },
    "wTZM1VKw": {
        "id": "wTZM1VKw",
        "title": "Spontaneous odontogenic differentiation and critical gene expression of mouse dental papilla mesenchymal cell in vitro",
        "abstract": "Objective To observe the spontaneous odontogenic differentiation of mouse dental papilla mesenchymal cells in blood serum medium. And to detect the critical gene expression of correlated transcription factors what are specific to odontogenic and osteogenic differentiation. Methods The primary dental papilla mesenchymal cells what had been obtained from E16. 5 d murine embryo were serially subcultivated in the simple serum medium and the serum medium supplemented with LIF(leukocyte inhibitory factor) respectively. It was observed whether the dental papilla mesenchymal cells differentiated into odontoblast phenotype or kept the undifferentiation phenotype. The mRNA expression of specific transcription factors were detected in cells with or without odontogenic differentiation. Results The fourth generation and behind of mouse dental papilla mesenchymal cells what were cultured in simple serum medium could spontaneously differentiate to odontoblast, while the undifferentiation phenotype of dental papilla mesenchymal cells could be lasting to ninth generation when they cultured in medium supplemented with 10 6 U/L LIF. Whether the dental papilla cells differentiate to odontogenic phenotype or not, the members of HOX gene family such as Msx1/Msx2, Pax9 and Lhx6/Lhx7 got completely expression. These transcription factors were specific to odontogenic mesenchymal cells. Also the specific gene of mineralized tissue cells such as DSPP, Sox9, Cbfa1 and Osx initiated to express after the odontoblast differentiation. Conclusion Not only this spontaneous odontogenic differentiation model of mouse dental papilla mesenchymal cells can be the positive control, but also the mode of gene expression can provide an evidence for studying how gene changes when adult stem cells are induced to odontogenic differentiation.",
        "keywords": [
            "Gene expression",
            "Leukocyte inhibitory factor",
            "Mouse dental papilla mesenchymal cells",
            "Odontogenic differentiation"
        ],
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "NIE Rong-rong",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Ling Wu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Dong Tlan",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2008
    },
    "PkcAofjT": {
        "id": "PkcAofjT",
        "title": "Mandibular coronoid fractures: treatment options.",
        "abstract": "Fractures of the coronoid process are uncommon and can easily be missed. The purpose of this study was to classify the fracture patterns and explore the treatment options. This retrospective study included 39 patients with fractures of the mandibular coronoid process. Treatment protocols were developed based on the time of fracture, degree of mouth opening, location of the coronoid fracture, types of fracture, and other concomitant fractures. All patients were followed up for 12-60 months. Sixteen patients underwent conservative management and four of these patients developed progressive trismus, which improved significantly after removal of the coronoid process. Twenty-three patients underwent open reduction and internal fixation (ORIF) via the modified retromandibular approach. Follow-up data showed significant improvement in maximum mouth opening and symptoms (diet and pain) compared to their preoperative status. In summary, conservative management is first recommended for fractures of the coronoid process with minimal displacement or restriction of mouth opening. For patients with significant fracture displacement and limited mouth opening, or with concomitant fractures of the zygoma, zygomatic arch, or mandibular ramus, ORIF via the modified retromandibular approach through the anterior border of the parotid gland is an alternative treatment method.",
        "keywords": [
            "conservative therapy",
            "coronoid fracture",
            "open reduction",
            "retromandibular approach"
        ],
        "authors": [
            {
                "name": "L Shen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "J Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "P Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "J Long",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "W Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "W Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "International journal of oral and maxillofacial surgery",
        "year": 2013
    },
    "e9LyAE21": {
        "id": "e9LyAE21",
        "title": "A study on the chondrogenesis of the compound of alginate gelatin and bone marrow stromal cells in vivo]",
        "abstract": "To investigate the chondrogenisis by alginate gelatin and rats' bone marrow stromal cells (BMSCs) chondrogenicly induced in vitro.Thirty-two male adult SD rats were assigned randomly to experimental and control groups. In experimental group, bone marrow was obtained from the right tibias of all the rats. After expanding and culturing 3 passages, induced BMSCs by chondrogenic culture medium for 10 days. Suspended induced cells in alginate gelatin, and injected the complex into the hypodermic tissue of the backs of rats autogenously. In control group only alginate gelatins were injected. The grafts were taken out for examinations 4 and 8 weeks after the operations.Considerable cartilage appeared in experimental group 8 weeks after operations. Regular HE staining and alcian blue staining showed a great deal of cartilage holding chondrocyte masses surrounded by abundant matrix. Alginate gelatin decompounded obviously, and the rest distributed among newly formed cartilage. No cartilage appeared in control group all through.BMSCs and alginate gelatin have a beautiful future in cartilage tissue engineering.",
        "keywords": [
            "tissue engineering",
            "cartilage",
            "mesenchymal stromal cells(mscs)",
            "alginate gelatin"
        ],
        "authors": [
            {
                "name": "Lei Liu",
                "org": "Key Laboratory of Oral Biomedical Engineering of Ministry of Education, Sichuan University, Chengdu, China."
            },
            {
                "name": "Rurt-liang Chen",
                "org": ""
            },
            {
                "name": "Wei-dong Tian",
                "org": ""
            },
            {
                "name": "Zheng-bin Yan",
                "org": ""
            },
            {
                "name": "Xi-zhe Chen",
                "org": ""
            },
            {
                "name": "Sheng-wei Li",
                "org": ""
            },
            {
                "name": "Tao Wang",
                "org": ""
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2005
    },
    "ivXGK8Nt": {
        "id": "ivXGK8Nt",
        "title": "Ectopic andin situ bone formation of adipose tissue-derived stromal cells in biphasic calcium phosphate nanocomposite",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Yunfeng Lin",
                "org": ""
            },
            {
                "name": "Tao Wang",
                "org": ""
            },
            {
                "name": "Ling Wu",
                "org": ""
            },
            {
                "name": "Wei Jing",
                "org": ""
            },
            {
                "name": "Xizhe Chen",
                "org": ""
            },
            {
                "name": "Zhiyong Li",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            },
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Xiaohui Zheng",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Journal of Biomedical Materials Research Part A",
        "year": 2007
    },
    "zJ4MlSCQ": {
        "id": "zJ4MlSCQ",
        "title": "Construction of Recombinant Adenovirus Vector for hBMP-2 Gene with Gateway~(TM)Clone Technology",
        "abstract": "Objective:To establish a recombinant adenovirus vector with BMP-2 by\u03bbphasge-site specific recombination systems. Methods:The target gene of hBMP-2 fragment was prepared from plasmid pcDNA3.1 and ligated into entry vector pENTRTM11 with attL1 and attL2 sites to generate the entry clone.Then the entry clone and the target vector Ad/CMV/V5-DEST with attL1 and attL2 sites was recombined together in vivo to create the expression clone(ad-BMP-2)LR under the action of the efficient recombines.After the expression clone confirmed by restriction analysis,PCR and sequencing,ad-BMP-2 was digested with Pac(?),and transferred into 293A cells to be packaged into adenovirus stock(Ad-hBMP-2).Ad-hBMP-2 was amplified by infection of 293A cells,and then the recombi- nant protein was analyzed by western blotting.Results:The target gene of hBMP-2 was transferred into Ad/CMV/V5-DEST vector cor- rectly with the right ORF(open reading frame)by LR recombination reaction and it was confirmed by restriction analysis,PCR and se- quencing.The expression clone ad-BMP-2 was packaged into maturated adenovirus successfully.The titer of Ad-hBMP-2 was 2.5\u00d710~9pfu/ml.It was confirmed with high-level expression of recombinant protein of hBMP-2 in 293A cells.Conclusions:It was the first time to construct Ad-hBMP-2 with an efficient and flexible system named Gateway~(TM)clone technology,and which lays a experimental foun-dation for the further research on physiological function of hBMP-2 and the genetic therapy of hBMP-2.",
        "keywords": [
            "BMP-2",
            "GatewayTM clone technology",
            "Recombinant adenovirus vector"
        ],
        "authors": [
            {
                "name": "JIANG Hong-mei",
                "org": "West China College of Stomatology,Sichuan University,Chengdu,,China"
            },
            {
                "name": "LONG Jie",
                "org": "West China College of Stomatology,Sichuan University,Chengdu,,China"
            },
            {
                "name": "TANG Wei",
                "org": "West China College of Stomatology,Sichuan University,Chengdu,,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "West China College of Stomatology,Sichuan University,Chengdu,,China"
            },
            {
                "name": "LIU lei",
                "org": "West China College of Stomatology,Sichuan University,Chengdu,,China"
            },
            {
                "name": "LIN Yun-feng",
                "org": "West China College of Stomatology,Sichuan University,Chengdu,,China"
            },
            {
                "name": "WANG Hang",
                "org": "West China College of Stomatology,Sichuan University,Chengdu,,China"
            },
            {
                "name": "LI Peng",
                "org": "West China College of Stomatology,Sichuan University,Chengdu,,China"
            }
        ],
        "venue": "Progress in Modern Biomedicine",
        "year": 2008
    },
    "rM4KddvD": {
        "id": "rM4KddvD",
        "title": "Database construction of maxillofacial trauma after Wenchuan earthquake using Microsoft Access 2000 system",
        "abstract": "Clinical data of 419 patients with maxillofacial injuries during initial one and half month after the Wenchuan earthquake from May 12th to June 30th, 2008 were collected, and the database was constructed using Microsoft Access 2000 combining with the questionnaire of maxillofacial trauma after 5.12 earthquake made by West China Hospital of Stomatology. A Microsoft Access 2000 database consisting of 419 patients with maxillofacial trauma was established and analyzed in one month. The database system was successfully constructed and operated smoothly, which had powerful capacity of information processing of case record. Microsoft Access 2000 is simple and practical in the construction of maxillofacial trauma database, which is beneficial to information management of case record and clinical, teaching and research work.",
        "keywords": [],
        "authors": [
            {
                "name": "Li Rui",
                "org": "Department of Maxillofacial Surgery, West China College of Stomatology, Sichuan University Chengdu , Sichuan Province, China"
            },
            {
                "name": "Wang Hang",
                "org": "Department of Maxillofacial Surgery, West China College of Stomatology, Sichuan University Chengdu , Sichuan Province, China;State Key Laboratory of Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu , Sichuan Province, China"
            },
            {
                "name": "Cao Yu-lu",
                "org": "Computer College of Sichuan University, Chengdu , Sichuan Province, China"
            },
            {
                "name": "Feng Zi-liang",
                "org": "Computer College of Sichuan University, Chengdu , Sichuan Province, China"
            },
            {
                "name": "Xiao Jin-gang",
                "org": "Department of Maxillofacial Surgery, West China College of Stomatology, Sichuan University Chengdu , Sichuan Province, China"
            },
            {
                "name": "Yang Xiao-juan",
                "org": "Department of Maxillofacial Surgery, West China College of Stomatology, Sichuan University Chengdu , Sichuan Province, China"
            },
            {
                "name": "Lu Qi",
                "org": "Department of Maxillofacial Surgery, West China College of Stomatology, Sichuan University Chengdu , Sichuan Province, China"
            },
            {
                "name": "Guo Li-juan",
                "org": "Department of Maxillofacial Surgery, West China College of Stomatology, Sichuan University Chengdu , Sichuan Province, China"
            },
            {
                "name": "Tian Wei-dong",
                "org": "Department of Maxillofacial Surgery, West China College of Stomatology, Sichuan University Chengdu , Sichuan Province, China;State Key Laboratory of Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu , Sichuan Province, China"
            }
        ],
        "venue": "Journal of Clinical Rehabilitative Tissue Engineering Research",
        "year": 2009
    },
    "CRt35FBn": {
        "id": "CRt35FBn",
        "title": "The Expression of Caveolin-1 mRNA in Tooth Development of Mouse",
        "abstract": "Objective:To study the expressidon of caveolin-1 mRNA in tooth development of mouse with different mes- enchymal cells.Methods:Total RNA was extracted from E9.5 ectoderm mesenchymal cells and E16.5 tooth germ mesenchymal cells of mouse and the gene mRNA was determined by using RT-PGR technique.Results:caveolin-1 mRNA was detected in both mesenchymal cells and its level in tooth germ mesenchymal cells is higer than that in ectoderm mesenchymal cells.Conclu- sion:caveolin-1 may play a important role in tooth development of mouse.",
        "keywords": [
            "Tooth development",
            "Mesenchymal cells",
            "Caveolin-1"
        ],
        "authors": [
            {
                "name": "YANG Lin",
                "org": "Department of Oral and Maxillofacial Surgery,West China College of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "HE Yong-hong",
                "org": "Department of Oral and Maxillofacial Surgery,West China College of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "SHEN Yong-dai",
                "org": "Department of Oral and Maxillofacial Surgery,West China College of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "LIU Lei",
                "org": "Department of Oral and Maxillofacial Surgery,West China College of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "TANG Wei",
                "org": "Department of Oral and Maxillofacial Surgery,West China College of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "Department of Oral and Maxillofacial Surgery,West China College of Stomatology,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Progress in Modern Biomedicine",
        "year": 2007
    },
    "wyrQV2xD": {
        "id": "wyrQV2xD",
        "title": "Transducin beta-TrCP expressed in developmental hair follicle of mice]",
        "abstract": "To identify the expression of antagonist beta-TrCP protein in Sonic hedgehog signal transduction pathway and Wnt signal transduction pathway in hair follicle tissues.The heads of day 18 embryo, and one day and six-days-old postnatal mice were acquired and treated with 40 g/L paraformaldehyde fixation for 48 h and paraffin embedding. The expression of beta-TrCP proteins was examined using LsAB (labelled streptavidin-biotin) method.beta-TrCP proteins were expressed in the cytoplasm of the hair stems of hair follicle, hair cuticle, cuticle of root sheath, Huxley's layer of internal root sheath cells, external root sheath and mesenchymal tissues, but not in connective tissue sheath and Henle's layer of internal root sheath.TrCP express in the developmental hair follicle tissues, which implicates that beta-TrCP regulate the developmental hair follicle by mediating the signal transduction pathways.",
        "keywords": [],
        "authors": [
            {
                "name": "Yong-dai Shen",
                "org": "State Key Laboratory of Oral Diseases, West China Stomatological Hospital, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Yong-hong He",
                "org": ""
            },
            {
                "name": "Lin Yang",
                "org": ""
            },
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            },
            {
                "name": "Wei-dong Tian",
                "org": ""
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2008
    },
    "B9tzpvkN": {
        "id": "B9tzpvkN",
        "title": "Prediabetes Enhances Periodontal Inflammation Consistent With Activation of TLR Mediated NF-\u043aB Pathway in Rats.",
        "abstract": "Clinical studies have showed that prediabetes is a predisposing factor for periodontitis. However, the pathogenic mechanism involved is unclear. Since it is known that the activation of toll like receptors (TLRs) mediated nuclear factor-kappaB (NF-\u043aB) signaling pathway plays a crucial role in periodontitis, we hypothesized that prediabetes enhances periodontal inflammation by activation of TLRs mediated NF-\u043aB pathway.In this study, we established prediabetes rat model by feeding high fat diet (HFD). High fat diet induced prediabetic rats (N=7) and normal chow feed rats (N=7) were studied. The animal model was characterized in terms of body weight (BW), the glycemic and insulinemic profiles. The following parameters were assessed to evaluate possible early periodontal alterations and underlying mechanisms: histology analysis of periodontal tissue, as well as the serum and mRNA levels and/or the tissue protein expression of TLRs, myeloid differentiation factor 88 (MyD88), TNF receptor associated factor 6 (TRAF6), NF-\u043aB, cytokines, advanced glucose ends (AGEs) and free fatty acids (FFAs).Prediabetic rats presented higher expression of TLR2 and TLR4 in periodontal tissue in the HFD group compared with the control group, respectively. The TLR2 and TLR4 was mostly expressed in gingiva, in addition to, TLR4 was expressed in periodontal ligament in rats. Furthermore, the MyD88 and TRAF6 protein levels were significantly increased in gingiva in prediabetic rats compared to normal rats. The activity of NF-\u043aB signals was higher in prediabetic rats than in normal rats. Regarding cytokines expression, the TNF-alpha (TNF-\u03b1) protein levels and IL-1betta (IL-1\u03b2) mRNA levels were significantly increased in the HFD group compared with the control group. In the serum, AGEs levels were significantly increased in the prediabetic rats. Mean FFAs concentrationswere increased in prediabetic rats, compared to normal rats; however, it did not reach statistical significance.In prediabetic rats, TLR2 and TLR4 gene and protein levels were higher expression in periodontal tissue, the activation of NF-\u043aB may through TLRs/MyD88, cause more cytokines secretion, which is associated with the onset or development of periodontal disease.",
        "keywords": [
            "high fat diet",
            "inflammation",
            "nuclear factor-kappaB",
            "prediabetes",
            "rats",
            "toll like receptors"
        ],
        "authors": [
            {
                "name": "Yanli Huang",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weihua Guo",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Jin Zeng",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Guoqing Chen",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Wenhua Sun",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Xuexin Zhang",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weidong Tian",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            }
        ],
        "venue": "Journal of periodontology",
        "year": 2015
    },
    "hcZC8Q6G": {
        "id": "hcZC8Q6G",
        "title": "Heterotopic osteogenesis of autogenous marrow stromal cells with recombinant human bone morphogenetic protein 2 gene transfection and porous calcium phosphate ceramic as a scaffold]",
        "abstract": "To observe the heterotopic osteogenesis of autogenous marrow stromal cells loading on porous calcium phosphate ceramic scaffolds with rhBMP2 gene transfection in a Sprague-Dawley rat model.Autogenous marrow stromal cells were obtained from left femurs and tibias of 20 male adult SD rats under general anesthesia and sterile condition and cultured in alpha-Minimal Essential Medium supplemented with 15% fetal bovine serum. RhBMP2 gene was transfected into stromal cells by means of LipofectAMINE 2000 reagent five days after primary culture. The stably gene expressive cells were selected with G-418 for 14 days and mixed with stromal cells without transfection. The mixture cells were seeded and subcultured for another 10 days in porous calcium phosphate bioceramic that had been subjected to surface-modification via soaking in human plasma fibronectin. The cell-ceramic compound was implanted subcutaneously and intramuscularly in the corresponding rat. Lab animals were sacrificed at two-week intervals till twenty weeks postoperatively and the involved samples were removed.Morphologic and histological study demonstrated that cell-ceramic compound had an ability of heterotopic osteogenesis, which was similar to that of autogenous osteoblasts in previous study.It seems that autogenous stromal cells with rhBMP2 transfection acts as a bioreactor promoting proliferation and differentiation of stem cells when they are replanted into the corresponding animals.",
        "keywords": [],
        "authors": [
            {
                "name": "Xizhe Chen",
                "org": "Key Lab. of Oral Biomedical Engineering, Sichuan University, Ministry of Education, Chengdu 610041, China."
            },
            {
                "name": "Lianjia Yang",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2003
    },
    "jDU0ulZH": {
        "id": "jDU0ulZH",
        "title": "Clinical analysis of midfacial fractures with orbital floor fractures]",
        "abstract": "To study the characters of the diagnosis and treatment for midfacial fractures with orbital floor fractures.136 cases of midfacial fractures with orbital floor fractures were diagnosed and treated. All patients underwent CT scans and accepted surgical intervention. Orbital floor fracture was restituted in 49 cases. Orbital floor defects were reconstructed with autogenous bone, titanium mesh or porous polyethylene implant (Medpor) in 21 cases.136 cases recovered well, their facial appearance and function were improved significantly. There were no severe complications happened postoperatively in all cases. 2 cases had postoperative wounds infection and 1 case had temporary ablepsia, but healed completely.CT is the best method for diagnosing orbital floor fractures. The objective of treatment is restoration of normal orbital floor and orbital capacity, the reduction of orbital contents prolapsed and reconstruction of orbital floor fractures with repair materials.",
        "keywords": [
            "midface fracture",
            "orbital floor fracture",
            "orbital floor reconstruction"
        ],
        "authors": [
            {
                "name": "Jin-gang Xiao",
                "org": "Dept.of Traumatic and Plastic Surgery,West China College of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Lei Liu",
                "org": "Dept.of Traumatic and Plastic Surgery,West China College of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Hai Dong",
                "org": "Dept.of Traumatic and Plastic Surgery,West China College of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Wei-dong Tian",
                "org": "Dept.of Traumatic and Plastic Surgery,West China College of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Xiao-yu Li",
                "org": "Dept.of Traumatic and Plastic Surgery,West China College of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Wei Tang",
                "org": "Dept.of Traumatic and Plastic Surgery,West China College of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Xiao-hui Zheng",
                "org": "Dept.of Traumatic and Plastic Surgery,West China College of Stomatology,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2007
    },
    "jXfggzpv": {
        "id": "jXfggzpv",
        "title": "MiR-154-5p regulates osteogenic differentiation of adipose-derived mesenchymal stem cells under tensile stress through the Wnt/PCP pathway by targeting Wnt11.",
        "abstract": "Mechanical stress is a well-acknowledged positive regulatory factor for osteogenic differentiation of adipose- derived mesenchymal stem cells (ADSCs). However, the molecular mechanisms associated with micro-RNAs (miRNAs) whereby ADSCs respond to mechanical stimuli remain elusive. We investigated the mechanism of mechanotransduction from the miRNA perspective in the osteogenic differentiation of ADSCs under tensile stress. Microarray analysis showed that miR-154-5p was remarkably downregulated when ADSCs were subjected to mechanical tension. Bioinformatics analysis with luciferase reporter assays demonstrated that Wnt11 3'UTR was a new direct target of miR-154-5p. Under tensile stress, lentivirus-mediated gain- or loss-of-function studies revealed that forced expression of miR-154-5p inhibited osteogenic differentiation of ADSCs, whereas inhibition of endogenous miR-154-5p with its antisense oligonucleotide (ASO-154-5p) obviously promoted osteogenic differentiation. Furthermore, miR-154-5p overexpression decreased activity of the non-canonical Wnt/PCP (RhoA-ROCK) pathway, as indicated by lower expression of Wnt11, active RhoA and ROCKII in miR-154-5p-treated ADSCs. By contrast, miR-154-5p inhibition activated the Wnt/PCP signals. Taken together, these results demonstrate that, under tensile stress, miR-154-5p negatively regulates ADSCs osteogenic differentiation through the Wnt/PCP pathway by directly targeting Wnt11. This novel regulatory pathway provides new insights into the molecular mechanism of mechanotransduction in osteogenic differentiation of ADSCs.",
        "keywords": [
            "adipose-derived mesenchymal stem cells",
            "mechanical stress",
            "micro-rna-154-5p",
            "osteogenic differentiation",
            "wnt11"
        ],
        "authors": [
            {
                "name": "Jianwei Li",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Chen Hu",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Lu Han",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Lei Liu",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Wei Jing",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Wei Tang",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Weidong Tian",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Jie Long",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, PR China; Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, PR China."
            }
        ],
        "venue": "Bone",
        "year": 2015
    },
    "MdZmSVDX": {
        "id": "MdZmSVDX",
        "title": "Maternal diabetes modulates dental epithelial stem cells proliferation and self-renewal in offspring through apurinic/apyrimidinicendonuclease 1-mediated DNA methylation",
        "abstract": "A Nature Research Journal",
        "keywords": "",
        "authors": [
            {
                "name": "Guoqing Chen",
                "org": "State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, 610041, P. R. China"
            },
            {
                "name": "Jie Chen",
                "org": "State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, 610041, P. R. China"
            },
            {
                "name": "Zhiling Yan",
                "org": "State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, 610041, P. R. China"
            },
            {
                "name": "Ziyue Li",
                "org": "State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, 610041, P. R. China"
            },
            {
                "name": "Mei Yu",
                "org": "State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, 610041, P. R. China"
            },
            {
                "name": "Weihua Guo",
                "org": "State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, 610041, P. R. China"
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, 610041, P. R. China"
            },
            {
                "name": "Guoqing Chen",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China College of Stomatology, Sichuan University, Chengdu, 610041, P. R. China"
            },
            {
                "name": "Jie Chen",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China College of Stomatology, Sichuan University, Chengdu, 610041, P. R. China"
            },
            {
                "name": "Zhiling Yan",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China College of Stomatology, Sichuan University, Chengdu, 610041, P. R. China"
            },
            {
                "name": "Ziyue Li",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China College of Stomatology, Sichuan University, Chengdu, 610041, P. R. China"
            },
            {
                "name": "Mei Yu",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China College of Stomatology, Sichuan University, Chengdu, 610041, P. R. China"
            },
            {
                "name": "Weihua Guo",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China College of Stomatology, Sichuan University, Chengdu, 610041, P. R. China"
            },
            {
                "name": "Weidong Tian",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China College of Stomatology, Sichuan University, Chengdu, 610041, P. R. China"
            },
            {
                "name": "Jie Chen",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, 610041, P. R. China"
            },
            {
                "name": "Zhiling Yan",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, 610041, P. R. China"
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, 610041, P. R. China"
            },
            {
                "name": "Weihua Guo",
                "org": "Department of Pedodontics, West China College of Stomatology, Sichuan University, No. 14, 3rd Section, Renmin South Road, Chengdu 610041, P. R. China"
            }
        ],
        "venue": "Scientific Reports",
        "year": 2017
    },
    "TyV9miWM": {
        "id": "TyV9miWM",
        "title": "Effect of insulin-like growth factor \u2160 and basic fibroblast growth factor on proliferation and differentiation of human dental papilla mesenchymal cells",
        "abstract": "BACKGROUND: Previous research has indicated that both insulin-like growth factor \u2160 (IGF-\u2160) and basic fibroblast growth factor (bFGF) play an important role in cell proliferation and differentiation. However, the effect on biological characteristics of human dental papilla mesenchymal cells (hDPMCs) still remains unclear. OBJECTIVE: To research the effect of IGF-\u2160 and bFGF on the proliferation and differentiation of hDPMCs. METHODS: hDPMCs were isolated and cultured in DMEM/F12 culture media containing 1% or 10% fetal bovine serum. The fourth-passaged hDPMCs were incubated in culture media containing 0, 0.1, 1, 10 and 100 \u03bcg/L bFGF and 0, 25, 50, 75 and 100 \u03bcg/L IGF-\u2160(0 \u03bcg/L as control group), respectively. At 96 hours after culture, proliferative activity was measured with MTT assay. The corresponding growth factor culture media were used in 10 \u03bcg/L bFGF group, 100 \u03bcg/L IGF-\u2160group, bFGF + IGF-\u2160 group, and control group, respectively. At days 1, 3, 5, and 7 after culture, the proliferative activity was detected using MTT assay, and alkaline phosphatase (ALP) activity was measured using modified enzyme kinetics method. RESULTS AND CONCLUSION: At the 0-100 \u03bcg/L mass concentration scope, both bFGF and IGF-\u2160could accelerate proliferation of hDPMCs, and the proliferation ability of bFGF was superior to that of IGF-\u2160; moreover, the combination of bFGF and IGF-\u2160caused a synergetic action to proliferation of hDPMCs. The maximal valid concentration of bFGF was 10 \u03bcg/L, and the maximal action concentration of IGF-\u2160was 100 \u03bcg/L. At 0-7 days, the effect of bFGF on the ALP activity of hDPMCs was not obvious, but the effect of IGF-\u2160on ALP activity of hDPMCs became greater with the time passing; furthermore, the combination of bFGF and IGF-\u2160could generate a synergetic action on increasing the ALP activity.",
        "keywords": [],
        "authors": [
            {
                "name": "Xie Jia-min",
                "org": "Department of Dentistry, Taizhou People's Hospital, Taizhou , Jiangsu Province, China"
            },
            {
                "name": "Tian Wei-dong",
                "org": "West China College of Stomatology, Sichuan University, Chengdu , Sichuan Province, China"
            },
            {
                "name": "Liu Lei",
                "org": "West China College of Stomatology, Sichuan University, Chengdu , Sichuan Province, China"
            }
        ],
        "venue": "Journal of Clinical Rehabilitative Tissue Engineering Research",
        "year": 2010
    },
    "IGX0GRQF": {
        "id": "IGX0GRQF",
        "title": "Study on multi-lineage potential of bone marrow mesenchymal stem cells derived from green fluorescent protein transgenic mice]",
        "abstract": "To study the multi-lineage potential of bone marrow mesenchymal stem cells (MSCs) derived from transgenic mice with green fluorescent protein (GFP) gene in vitro.A 6-week-old GFP transgenic mouse was executed by dislocation of cervical vertebra, and the marrow in tibia and thighbone was washed out with asepsis. The limited cell strains of MSCs derived from GFP transgenic mice (GFP-MSCs) were obtained with density gradient centrifugation. The passage 3 GFP-MSCs were induced to differentiate into osteoblast, adippcyte, neuron with solution of calcium induction medium, adipogenic medium and neural induction medium respectively. After being calcium-induced, the activity of alkaline phosphatase on GFP-MSCs was determined by micro-plate reader, and alizarin red staining was performed to test the formation of calcium concentration. The adipo-induced MSCs were detected with oil red O staining. Immunocytochemical staining was performed to detect the expression of NSE on neuron-induced MSCs.The ALP activity of GFP-MSCs heightened gradually along with being calcium-induced, and alizarin red staining showed positive. Oil red O staining of adipo-induced cells and NSE immunocytochemical staining of neuron-induced cells demonstrated positive.The limited cell strain of GFP-MSCs possesses multi-lineage potential, which can be used as an efficient tracking facility for studying the mechanism of multi-lineage potential on the MSCs.",
        "keywords": [
            "green fluorescent protein",
            "mensenchymal stem cells",
            "transgenic mice",
            "multi-lineage potential"
        ],
        "authors": [
            {
                "name": "Zhi-Yong Li",
                "org": "Key Lab. of Oral Biomedical Engineering of Ministry of Education, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Wei-Dong Tian",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            },
            {
                "name": "Xi-Zhe Chen",
                "org": ""
            },
            {
                "name": "Yun-Feng Lin",
                "org": ""
            },
            {
                "name": "Zheng-Bin Yan",
                "org": ""
            },
            {
                "name": "Ling Chen",
                "org": ""
            },
            {
                "name": "Sheng-Wei Li",
                "org": ""
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2005
    },
    "iwgPTntZ": {
        "id": "iwgPTntZ",
        "title": "A study on transfecting green fluorescent protein gene to rat bone marrow mesenchymal stem cells]",
        "abstract": "To study an efficient method to transfect green fluorescent protein gene (GFP) to rat bone marrow mesenchymal stem cells (MSCs) and to determine the biological properties and differentiation potency of transfected MSCs.SD rats' bone marrow MSCs were separated and purified in vitro. After subculture and expansion, MSCs infected with Adenoviral vector (Ad-GFP) or transfected with liposome were observed, and their transfection efficiency was assessed with flow cytometry. The MSCs expressing GFP gene were induced to differentiate to osteoblast, and non-transfected MSCs were set as control.Ad-GFP delivered GFP gene with high efficiency to rat MSCs. (41.3 +/- 1.4)% of MSCs infected with Ad-GFP expressed GFP gene, which was much higher than the control (12.5%). Expression of GFP gene of infected MSCs maintained stable from 1 to 6 weeks after infection. Infected MSCs possessed the same alkaline phosphatase activation as non-infected MSCs, and formed mineralized mouldes.The infected MSCs with Ad-GFP expressed GFP with much higher efficiency than liposome transfection, and maintained the same ability of proliferation and differentiation as non-infected MSCs. Transfection with Ad-GFP is a highly effective method for labeling MSCs.",
        "keywords": [
            "stem cells",
            "transfection",
            "fluorescent antibody technique",
            "cell differentiation"
        ],
        "authors": [
            {
                "name": "Zhi-yong Li",
                "org": "Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Lei Liu",
                "org": ""
            },
            {
                "name": "Wei-dong Tian",
                "org": ""
            },
            {
                "name": "Xi-zhe Chen",
                "org": ""
            },
            {
                "name": "Zheng-bin Yan",
                "org": ""
            },
            {
                "name": "Yun-feng Lin",
                "org": ""
            }
        ],
        "venue": "Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology",
        "year": 2005
    },
    "t27wYMnA": {
        "id": "t27wYMnA",
        "title": "Explant culture: an efficient method to isolate adipose-derived stromal cells for tissue engineering.",
        "abstract": "Enzymatic digestion, the commonly used method of adipose-derived stromal cells isolation, is time consuming and expensive, especially when applied to large volumes of tissue. In the present study, the characteristics of the cells obtained by adipose tissue explant culture were studied. We found that adipose tissue fragments could adhere onto the growth surface of flasks in a very short time after plating and that fibroblast-like cells migrated from the explants and reached confluence. Morphologic analysis and surface markers expression suggested the mesenchymal origin of the cells derived from adipose tissue explants. After in vitro expansion these cells were successfully induced into adipogenic, osteogenic, and chondrogenic lineages, which demonstrated their multipotency. The high growth rate and colony-forming efficiency of explant-derived cells were similar to those of cells obtained by digestion. Furthermore, explant culture gave higher yield of cells than digestion method after primary culture. The experiment of ectopic adipogenesis in nude mice suggested the prospects for tissue engineering of these cells. In conclusion, we obtained multipotent stromal cells from adipose tissue by explant culture, and this method was simple, time saving, and gave a high yield of cells. Therefore, explant culture can be used as an effective way to isolate adipose-derived stromal cells for tissue engineering.",
        "keywords": [
            "digestion",
            "adipose-derived stromal cells",
            "tissue engineering",
            "cell isolation",
            "explant culture"
        ],
        "authors": [
            {
                "name": "Wei Jing",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jingang Xiao",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Zhonghua Xiong",
                "org": "Sichuan Cancer Hospital and Institute(Sichuan Cancer Hospital,Sichuan Cancer Institute),Chengdu,China"
            },
            {
                "name": "Xingmei Yang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yuanding Huang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Min Zhou",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Sixiu Chen",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yunfeng Lin",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Artificial organs",
        "year": 2011
    },
    "8rq5QWqG": {
        "id": "8rq5QWqG",
        "title": "Cultivation and induced differentiation of bone marrow stromal cells of SD rats with type I osteoporosis in vitro]",
        "abstract": "To study the biological features and osteoblast/adipocyte phenotypes of bone marrow stromal cells (BMSCs) of Sprague-Dawley (SD) rats with Type I osteoporosis by induced culture.Six-month-old SD rats were used in this study. 16 female rats were randomly divided into two groups. Eight rats were ovariectomied as experimental group to establish the modle of Type I osteoporosis, while other rats received sham-operation. Three month later BMSCs of 16 rats were isolated by discontinueous gradient centrifugation and then plated in alpha-MEM medium as primary culture. Secondary harvested cells were cultured for 14 days in alpha-MEM medium supplemented with dexamethasone, ascorbic acid, vitamin D3, beta-glycerophosphate or dexamethasone, 3-isobutyl-1-methylxanthine, insuline, and indomethine. The cells were screened by inverted microscope each day and cell growth was studied with cell counting. The osteoblast and adipocyte phenotypes were verified by cytochemistry staining, counted the percentage of positive stained cells.The weight and bone mineral density of rats were statistically different between experimental group and control group. Gomori and Von Kossa's staining demonstrated positive osteoblast phenotypes of alkaline phosphatase and mineralized nods by osteogenic inducer, while Oil Red O staining identified BMSCs treated with adipogenic medium resulted in adipocyte formation and there was no significant difference in the percentage of positive stained cells between two groups.The model of Type I osteoporosis has been established successfully. BMSCs from SD rats with osteoporosis maintain their differentiation potential.",
        "keywords": [],
        "authors": [
            {
                "name": "You-Chao Tang",
                "org": "Key Lab. of Oral Biomedical Engineering of Ministry of Education, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Wei-Dong Tian",
                "org": ""
            },
            {
                "name": "Xi-Zhe Chen",
                "org": ""
            },
            {
                "name": "Sheng-Wei Li",
                "org": ""
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2005
    },
    "D5hn88xG": {
        "id": "D5hn88xG",
        "title": "Multilineage differentiation of adipose-derived stromal cells from GFP transgenic mice.",
        "abstract": "Functional engineering of musculoskeletal tissues generally involves rapid expansion of progenitor cells in vitro while retaining their potential for further differentiation and then induction in specific culture conditions. The autologous adipose-derived stromal cells (ASCs) are considered to contain pluripotent mesenchymal stem cells. Imaging with expression of green fluorescent protein (GFP) facilitates the detailed research on ASCs physiological behavior during differentiation into a variety of cell lineages both in vitro and in vivo. In this study, we aimed to confirm the trans-germ plasticity of homogeneously marked ASCs from GFP transgenic mice. Simultaneously, the term and intensity of GFP expression in ASCs were also focused on during variant inductions, when cells were incubated with multiple growth factors and adjuvant. ASCs were harvested from inguinal fat pads of transgenic nude mice, passaged 3 times in monolayer cultures, and then transferred to osteogenic, adipogenic, neurogenic, and myogenic medium. The morphological characterization of inductive cells was observed using phase-contrast microscopy and histological staining such as alizarin red for mineralization nodules and oil red O for lipid accumulation. The expression of marker genes or proteins was measured using RT-PCR and immunocytochemical analysis. Collagen type I, osteopontin (OPN), and osteocalcin (OCN) were positive in osteogenic lineages, peroxisome proliferator-activated receptor(PPAR)-gamma2 and lipoprotein lipase (LPL) were positive in adipogenic ones, glial fibrillary acidic protein (GFAP) and neuron-specific enolase (NSE) were positive in neurogenic ones, and alpha-smooth muscle actin (alpha-SMA) was positive in myogenic ones. Moreover, the results of fluorescence microscopic imaging suggested that there was no significant decline of GFP expression during ASCs differentiation and the level of GFP maintained stable till differentiated ASCs showed apoptotic phenotype. So the endogenous GFP and multilineage potential of transgenic ASCs had no influences on each other. Since the population of GFP ASCs can be easily identified, it is proposed that they may be promising candidate seed cells for further studies on ASCs tissue engineering, especially the study on engineered tissues formed in vivo.",
        "keywords": [
            "multilineage differentiation",
            "of Adipose-Derived stromal cells",
            "from GFP transgenic mice"
        ],
        "authors": [
            {
                "name": "Yunfeng Lin",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R.China"
            },
            {
                "name": "Xizhe Chen",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R.China"
            },
            {
                "name": "Zhengbin Yan",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R.China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R.China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R.China"
            },
            {
                "name": "Xiaohui Zheng",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R.China"
            },
            {
                "name": "Zhiyong Li",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R.China"
            },
            {
                "name": "Ju Qiao",
                "org": "Sichuan University Department of Orthodontics, West China College of Stomatology Chengdu 610041 P.R.China"
            },
            {
                "name": "Shengwei Li",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R.China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University Department of Oral and Maxillofacial Surgery, West China College of Stomatology Chengdu 610041 P.R.China"
            }
        ],
        "venue": "Molecular and cellular biochemistry",
        "year": 2006
    },
    "vEwXOAhD": {
        "id": "vEwXOAhD",
        "title": "Human treated dentin matrix as a natural scaffold for complete human dentin tissue regeneration.",
        "abstract": "An essential aspect of tooth tissue engineering is the identification of suitable scaffolding materials to support cell growth and tissue regeneration. Treated dentin matrix (TDM) from a rat has recently been shown to be a suitable scaffold for rat dentin regeneration. However, due to species-specific differences, it remains unclear whether a similar fabrication method can be extended to human TDM and human dentin regeneration. Therefore, this present study explored the biological response to a human TDM (hTDM) created using a modified dentin treatment method. Various biological characteristics, including cell proliferation, cell migration, cell viability, and cytotoxity were investigated. To assess the inductive capacity of hTDM, dental follicle cells (DFCs) were combined with hTDM and were implanted in vivo for 8 weeks in a mouse model. The resulting grafts were studied histologically. The results showed hTDM released dentinogenic factors, indicating that hTDM could play a sustained role in odontogenesis. DFC attachment, growth, viability, and cytotoxicity on the surface of hTDM showed a notable improvement over those on calcium phosphate controls. Most importantly, in vivo hTDM induced and supported regeneration of complete dentin tissues, which expressed dentin markers DSP and DMP-1. As cells in and around the regenerated dentin were positive for human mitochondria, implanted DFCs and hTDM were responsible for the regenerated dentin tissues. In conclusion, hTDM is indicated as an ideal biomaterial for human dentin regeneration.",
        "keywords": [
            "tooth",
            "microenvironment",
            "regeneration",
            "natural scaffold",
            "stem cells",
            "dentin matrix",
            "cell viability",
            "cell growth",
            "stem cell",
            "cell migration",
            "tissue engineering",
            "cell proliferation",
            "calcium phosphate"
        ],
        "authors": [
            {
                "name": "Rui Li",
                "org": ""
            },
            {
                "name": "Weihua Guo",
                "org": ""
            },
            {
                "name": "Bo Yang",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, No.14, 3rd Section, Renmin South Road, Chengdu 610041, PR China"
            },
            {
                "name": "Lijuan Guo",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, No.14, 3rd Section, Renmin South Road, Chengdu 610041, PR China"
            },
            {
                "name": "Lei Sheng",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, No.14, 3rd Section, Renmin South Road, Chengdu 610041, PR China"
            },
            {
                "name": "Gang Chen",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, No.14, 3rd Section, Renmin South Road, Chengdu 610041, PR China"
            },
            {
                "name": "Ye Li",
                "org": "State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, PR China"
            },
            {
                "name": "Qing Zou",
                "org": "State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, PR China"
            },
            {
                "name": "Dan Xie",
                "org": "State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, PR China"
            },
            {
                "name": "Xiaoxue An",
                "org": "State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, PR China"
            },
            {
                "name": "Yali Chen",
                "org": "State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, PR China"
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Biomaterials",
        "year": 2011
    },
    "jKojpKtF": {
        "id": "jKojpKtF",
        "title": "An experimental study on rat bone marrow mesenchymal stem cells transfected with dentin sialophosphoprotein gene in vitro]",
        "abstract": "To evaluate the expression of dentin sialophosphoprotein (DSPP) in transfected rat bone marrow mesenchymal stem cells (BM-MSC) and the influence of the transfection.Plasmid containing mice dentin DSPP was constructed by using the cytomegalovirus (CMV) promoter and then transfected the cultured BM-MSC by lipofectamine; The expression of Pax-9 and dentin matrix protein 1 (DMP1) gene of transfected BM-MSC were detected by RT-PCR. The expression of DSPP was examined by immunocytochemical staining, and the formation ratio of mineralized nodules of transfected BM-MSC was compared with untransfected ones after mineralized induction.The constructed pcDNA3.1(+)/mDSPP could produced 3.0 kb and 5.4 kb fragments, DSPP gene and Pax9 gene were expressed 24 h and 48 h respectively, after BM-MSC were transfected Pax-9 gene was exprssed, but DMP1 gene was not; Immunohistochemical staining showed that DSPP was positive in transfected BM-MSC; The formation ratio of mineralized nodules of transfected BM-MSC was higher than that of untransfected ones after mineralized induction.The expression of mice DSPP in BM-MSC by gene transfection can induce the expression of tooth development-associated gene Pax9 and enhance the formation of mineralized nodules, which suggests that DSPP gene might induce odontogenic differentiation of BM-MSC.",
        "keywords": [
            "stem cells",
            "phosphoproteins",
            "stromal cells"
        ],
        "authors": [
            {
                "name": "Zhi-yong Li",
                "org": "Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, College of Medical Sciences, Zhejiang University, Hangzhou 310003, China."
            },
            {
                "name": "Lei Liu",
                "org": ""
            },
            {
                "name": "Ling Chen",
                "org": ""
            },
            {
                "name": "Yun-feng Lin",
                "org": ""
            },
            {
                "name": "Wei-dong Tian",
                "org": ""
            }
        ],
        "venue": "Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology",
        "year": 2006
    },
    "jcTWiNGJ": {
        "id": "jcTWiNGJ",
        "title": "Combination of aligned PLGA/Gelatin electrospun sheets, native dental pulp extracellular matrix and treated dentin matrix as substrates for tooth root regeneration.",
        "abstract": "In tissue engineering, scaffold materials provide effective structural support to promote the repair of damaged tissues or organs through simulating the extracellular matrix (ECM) microenvironments for stem cells. This study hypothesized that simulating the ECM microenvironments of periodontium and dental pulp/dentin complexes would contribute to the regeneration of tooth root. Here, aligned PLGA/Gelatin electrospun sheet (APES), treated dentin matrix (TDM) and native dental pulp extracellular matrix (DPEM) were fabricated and combined into APES/TDM and DPEM/TDM for periodontium and dental pulp regeneration, respectively. This study firstly examined the physicochemical properties and biocompatibilities of both APES and DPEM in vitro, and further investigated the degradation of APES and revascularization of DPEM in vivo. Then, the potency of APES/TDM and DPEM/TDM in odontogenic induction was evaluated via co-culture with dental stem cells. Finally, we verified the periodontium and dental pulp/dentin complex regeneration in the jaw of miniature swine. Results showed that APES possessed aligned fiber orientation which guided cell proliferation while DPEM preserved the intrinsic fiber structure and ECM proteins. Importantly, both APES/TDM and DPEM/TDM facilitated the odontogenic differentiation of dental stem cells in vitro. Seeded with stem cells, the sandwich composites (APES/TDM/DPEM) generated tooth root-like tissues after being transplanted in porcine jaws for 12 w. In dental pulp/dentin complex-like tissues, columnar odontoblasts-like layer arranged along the interface between newly-formed predentin matrix and dental pulp-like tissues in which blood vessels could be found; in periodontium complex-like tissues, cellular cementum and periodontal ligament (PDL)-like tissues were generated on the TDM surface. Thus, above results suggest that APES and DPEM exhibiting appropriate physicochemical properties and well biocompatibilities, in accompany with TDM, could make up an ECM microenvironment for tooth root regeneration, which also offers a strategy for complex tissue or organ regeneration.",
        "keywords": [
            "Electrospun sheet",
            "Extracellular matrix",
            "Decellularization",
            "Tooth root",
            "Regeneration"
        ],
        "authors": [
            {
                "name": "Gang Chen",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China."
            },
            {
                "name": "Jinlong Chen",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China."
            },
            {
                "name": "Bo Yang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China."
            },
            {
                "name": "Lei Li",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China."
            },
            {
                "name": "Xiangyou Luo",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China."
            },
            {
                "name": "Xuexin Zhang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China."
            },
            {
                "name": "Lian Feng",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China."
            },
            {
                "name": "Zongting Jiang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China."
            },
            {
                "name": "Mei Yu",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China."
            },
            {
                "name": "Weihua Guo",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China; Department of Pedodontics, West China College of Stomatology, Sichuan University, No.14, 3rd Section, Renmin South Road, Chengdu, 610041, PR China."
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China."
            }
        ],
        "venue": "Biomaterials",
        "year": 2015
    },
    "zPYX6ZXK": {
        "id": "zPYX6ZXK",
        "title": "Platelet-rich plasma effects on grainy fat transplantation",
        "abstract": "BACKGROUND: The higher long-term absorption rate greatly influence the widely application of fat transplantation. Platelet-rich plasma contains a high concentration of growth factors, which benefits to the tissue healing and regeneration. OBJECTIVE: To observe the effects of platelet-rich plasma on grainy fat transplantation and to investigate the mechanisms preliminarily. METHODS: Ten 6-week-old nude mice were prepared. The right or left dorsal subcutaneous tissues were randomly selected as the platelet-rich plasma group (0.5 mL fat granule+0.1 mL platelet-rich plasma), and the contralateral side was regarded as the control group (0.5 mL fat granule+0.1 mL phosphate-buffered saline). At 10 and 90 days after implantation, five nude mice were selected from each group, and then the mice were sacrificed to obtain the grafts in each group for general appearance observation, volume determination and histological detection. Furthermore, we isolated adipose-derived stem cells from human subcutaneous fat tissue during the in vitro experiment. Cell counting kit-8 and real-time PCR were used to evaluate the influence of platelet-rich plasma on adipose-derived stem cell proliferation and adipogenic differentiation in vitro, respectively. RESULTS AND CONCLUSION: Comparison of the grafts obtained at 10 and 90 days after implantation, the residual volume in the platelet-rich plasma group was significantly larger than that in the control group (P < 0.05), Moreover, more normal adipocytes and capillary formation were observed in the platelet-rich plasma group (P < 0.05). For in vitro experiment, platelet-rich plasma could significantly improve adipose-derived stem cell proliferation, and the expressions of adipogenic-related genes were up-regulated in platelet-rich plasma-induced adipose-derived stem cells. All results demonstrate that platelet-rich plasma can improve the survival of fat grafts,which might be closely related to that platelet-rich plasma can promote the proliferation and adipogenic differentiation of adipose-derived stem cells and the revascularization in grafted fat tissue.",
        "keywords": [
            "Adipogenic differentiation",
            "Adipose-derived stem cells",
            "Angiogenesis",
            "Cell proliferation",
            "Cell transplantation",
            "National Natural Science Foundation of China",
            "Organ transplantation",
            "Platelet-rich plasma"
        ],
        "authors": [
            {
                "name": "Li Feng",
                "org": " State Key Laboratory of Oral Diseases, Sichuan University, Chengdu , Sichuan Province, China"
            },
            {
                "name": "Li Kun",
                "org": " State Key Laboratory of Oral Diseases, Sichuan University, Chengdu , Sichuan Province, China"
            },
            {
                "name": "Li Jie",
                "org": " State Key Laboratory of Oral Diseases, Sichuan University, Chengdu , Sichuan Province, China"
            },
            {
                "name": "Tian Wei-dong",
                "org": " State Key Laboratory of Oral Diseases, Sichuan University, Chengdu , Sichuan Province, China"
            }
        ],
        "venue": "Chinese Journal of Tissue Engineering Research",
        "year": 2013
    },
    "ednPgnVC": {
        "id": "ednPgnVC",
        "title": "Construction of recombinant gene adenovirus encoding enhanced green fluorecence protein-peroxisome proliferator-activated receptor gamma2 fusion protein and its expression in bone marrow mesenchymal stem cells]",
        "abstract": "To construct mouse enhanced green fluorecence protein (EGFP) -peroxisome proliferator-activated receptor (PPAR)gamma2, and to detect EGFP-PPARgamma2 expression in infected mouse bone marrow mesenchymal stem cells (BMSC).Cut the fragment of PPARgamma2 from the expression plasmid pcDNA flag PPARgamma2, then cloned the gene fragment into pEGFP-C1 and pEGFP-N1 vector. Subsequently, subclone the fragment EGFP-PPARgamma2 from pEGFP-C1-PPARgamma2 into the shuttle plasmid DC315. HEK293 cells were co-transfected with the constructed recombinant shuttle plasmid DC315-EGFP-PPARgamma2 and large adenovirus helper plasmid pBHGlox deltaE1, 3Cre in mediation of liposome. The obtained replication-defective recombinant adenovirus Ad-EGFP-PPARgamma2 was confirmed. Then it was propagated in HEK293 cells. After the BMSC were transfected for 72 h, adipogenic differentiation was demonstrated.HEK293 cells were transfected with the pEGFP-C1-PPARgamma2 or pEGFP-N1-PPARgamma2 in mediation of liposome. The former green fluorescence protein was better than the latter by fluorescence microscope. The recombinant plasmids were digested and identified. Western blot analysis showed the expression of EGFP-PPARgamma2 in vitro. EGFP-PPARgamma2 protein was detectable in the nucleus of BMSC.The recombinant adenovirus encoding EGFP-PPARgamma2 fusion protein was successfully constructed, which provided a basis for application of EGFP-PPARgamma2 gene to adenovirus-mediated gene therapy.",
        "keywords": [
            "recombinant adenovirus",
            "peroxisome proliferator-activated receptor",
            "bone marrow mesenchymal stem cell"
        ],
        "authors": [
            {
                "name": "Li-zi Liao",
                "org": "Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Jin-gang Xiao",
                "org": "State Key Laboratory of Oral Diseases,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Miao-miao Yang",
                "org": "State Key Laboratory of Oral Diseases,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Zi-ren Kong",
                "org": "State Key Laboratory of Oral Diseases,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Qin-ce Sun",
                "org": "College of Life Science,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Wei-dong Tian",
                "org": "State Key Laboratory of Oral Diseases,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2010
    },
    "79d69LEZ": {
        "id": "79d69LEZ",
        "title": "Influence of exogenous nitric oxide on chondrogenic differentiation of adipose derived stem cells]",
        "abstract": "To determine the effects of exogenous nitric oxide (NO) donor sodium nitroprusside (SNP) on the proliferation and expression of related-gene of adipose-derived stem cells(ADSCs) and its role in chondrogenic differentiation of ADSCs.Rat ADSCs were harvested and cultured, and then induced to osteogenic and adipogenic differentiations, detected with Alizarin red stained and Oil red O stain, respectively. The change of NO during chondrogenic differentiation of ADSCs was tested by NO detection kit. Cell counting kit-8 (CCK8) was used to detect the proliferation of ADSCs under different concentrations of SNP (0.25 mmol/L, 1.00 mmol/L, 4.00 mmol/L). Gene expression level of transformation growth factor (TGF-beta1) and specific gene of chondrogenic differentiation-signaling protein Smad3 and Collage II alPHA (Col-II alpha1), were detected by Real time- PCR (RT-PCR) method.Positive alizarin red staining and Oil red O staining were found after osteogenic and adipogenic induction of cultured ADSCs. Higher concentrations of NO were found in the supernatant of the experimental group with ADSCs chondrogenic differentiations compared with the controls (P<0.05). Low concentrations (0. 25 mmol/L, 1.00 mmol/L) of SNP showed no significant effects on cell proliferations (P>0.05), whereas high concentration (4. 00 mmol/L) of SNP inhibited cell proliferation (P<0.05). RT-PCR revealed that SNP inhibited the gene expression of TGF-beta1 mRNA and chondrogenic differentiation of specific gene Smad3 mRNA, Col-II alpha1 mRNA.SNP can inhibit chondrogenic differentiations by suppressing the production of TGF-beta1 and inhibiting downstream of TGF-beta1 signaling pathways, thereby inhibiting ADSCs differentiation into chondrocytes.",
        "keywords": [],
        "authors": [
            {
                "name": "Shuang Liu",
                "org": ""
            },
            {
                "name": "Hai-sen Huang",
                "org": ""
            },
            {
                "name": "Mei Yu",
                "org": ""
            },
            {
                "name": "Xiao-rin Luo",
                "org": ""
            },
            {
                "name": "Wei-hua Guo",
                "org": ""
            },
            {
                "name": "Wei-dong Tian",
                "org": ""
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2015
    },
    "fTYUhp38": {
        "id": "fTYUhp38",
        "title": "Construction of beta-catenin miRNA-expressing vectors and test of silencing effect in adipose-derived stem cells from Sprague-Dawley rats]",
        "abstract": "OBEJECTIVE: To construct miRNA-expressing plasmid vector for interfering the expression of beta-catenin in adipose-derived stem cells from Sprague-Dawley rats.The double strands oligonucleotides of miR-expressing cassette were ligated into plasmid pSWH to generate pSWH-miR. Then the PCR product of enhanced green fluorescence protein (EGFP) open reading frame (ORF) fragment was inserted into BamH I and Xbo I digested pSWH-miR to generate pSWH-EGFP-miR. The adipose-derived stemcells from rats (rADSCs) were transfected with pSWH-EGFP-miR respectively. The expression of beta-catenin was determined by Western blot at 72 h post-transfection.Five miRNA-expressing plasmid vectors were constructed (miR-780, miR-796, miR-1467, miR-1948, miR-1960). miR-780 and miR-796 had the best silencing effect on the expression of beta-catenin (P < 0.05), less did the miR-1960 (P < 0.05), but not the miR-1467 and the miR-1948 (P < 0.05).miR-780 and miR-796 could interference the beta-catenin in ADSCs with high efficiency.",
        "keywords": [],
        "authors": [
            {
                "name": "Hai-Sen Huang",
                "org": ""
            },
            {
                "name": "Shuang Liu",
                "org": ""
            },
            {
                "name": "Mei Yu",
                "org": ""
            },
            {
                "name": "Xiao-Xin Luo",
                "org": ""
            },
            {
                "name": "Wei-Hua Guo",
                "org": ""
            },
            {
                "name": "Wei-Dong Tian",
                "org": ""
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2014
    },
    "5lCru63Q": {
        "id": "5lCru63Q",
        "title": "In vitro study on cranial neural crest differentiating into ectomesenchymal cell of the first branchial arch by FGF-8]",
        "abstract": "To investigate the effects of FGF-8 on cranial neural crest cell (CNCC) differentiating into ectomesenchymal cell of the first branchial arch, and determine the appropriate dose and stage of CNCC exposure to FGF-8.Cranial neural crest explants were cultured in free-serum medium containing modified DMEM/F12 and different doses of FGF-8. The differentiation type of CNCC were determined by in situ hybridization for Hoxa2 and immunocytochemistry for vimentin.Pre-emigrating CNCC demonstrated the negative Hoxa2 stain and positive vimentin stain after treated by 100 ug/FGF-8. Both post-emigrating CNCC group and control group were positive for Hoxa2 and vimentin stain.On the early stage of CNCC emigration, the first branchial arch phenotype of CNCC could be induced by FGF-8. This experiment could provide in vitro model for study on the mechanism of tooth-jaw regeneration.",
        "keywords": [
            "cranial nerves",
            "ectoderm",
            "branchial region",
            "cell differentiation"
        ],
        "authors": [
            {
                "name": "Hong-bing Jiang",
                "org": "Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Wei-dong Tian",
                "org": ""
            },
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            },
            {
                "name": "Xiao-dong Li",
                "org": ""
            }
        ],
        "venue": "Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology",
        "year": 2005
    },
    "cvtUGpgW": {
        "id": "cvtUGpgW",
        "title": "Comparison on the osteogenesis potential between poly(lactide-co-glycolide) and alginate as bone tissue engineering scaffold in vivo",
        "abstract": "Poly(lactide-co-glycolide) (PLGA) and alginate(AG) are the most promising scaffolds in the bone tissue engineering for their stable mechanical characters and three-dimensional porous structure. This study aimed to assay the in vivo osteogenesis potentials by loading the autogenous bone marrow stromal cells (BMSCs) on PLGA or AG. The results suggested that PLGA and AG are both ideal bone tissue engineering scaffold. BMSCs/AG has stronger osteogenesis potentials in vivo than BMSCs/PLGA.",
        "keywords": [
            "Alginate",
            "Bone marrow stromal cells",
            "Osteogenesis potential",
            "Poly(lactide-co-glycolide)"
        ],
        "authors": [
            {
                "name": "Li Cai",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Chen Runliang",
                "org": "First People's Hospital of Tianjin(Tianjin Second People's Hospital,First People's Hospital of Tianjin),Tianjin,China"
            },
            {
                "name": "Liu Lei",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lin Yunfeng",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Tian Weidong",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Li Shengwei",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Key Engineering Materials",
        "year": 2007
    },
    "VWin8bv4": {
        "id": "VWin8bv4",
        "title": "In vitro culture and biological characteristics of cranial neural crest stem cell]",
        "abstract": "According to development biology, cranial neural crest stem cell (CNCSC) can differentiate into precursor cells of tooth, jaw and peripheral nerve system, but in vitro study is less reported. In the present study, CNCSC were dissociated and cultured in vitro, and the biological characteristics of CNCSC was investigated.Cranial neural tubes, dissected from mouse E9d, were explanted onto fibronectin-coated dishes. CNCSCs emigrated from the explanted neural tubes, cultured in a serum-free medium containing modified DMEM/F12. Biological characteristics of CNCSC were detected by morphology, nuclear labeled with BurdU and immunocytochemistry.Fibroblast-like CNCSCs demonstrated the characteristics of stem cell, such as clonality, self-renewal and multipotentiality. The result of immunocytochemical stain showed that CNCSC expressed HNK-1 antigen.CNCSC were cultured successfully, providing a experimental basis for study on tooth/jaw-like differentiation of CNCSC in vitro, especially providing a cell source for investigating tooth/jaw regeneration.",
        "keywords": [],
        "authors": [
            {
                "name": "Wei-dong Tian",
                "org": "Laboratory of Oral Biomedical Engineering Ministry of Education, Sichuan University, Chengdu, China."
            },
            {
                "name": "Hong-bing Jiang",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            },
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Xiao-dong Li",
                "org": ""
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2004
    },
    "CKbZJYTi": {
        "id": "CKbZJYTi",
        "title": "Transducin \u03b2-TrCP Expressed in Developmental Hair Follicle of Mice",
        "abstract": "Objective To identify the expression of antagonist \u03b2-TrCP protein in Sonic hedgehog signal transduction pathway and Wnt signal transduction pathway in hair follicle tissues.Methods The heads of day 18 embryo,and one day and six days old postnatal mice were acquired and treated with 40 g/L paraformaldehyde fixation for 48 h and paraffin embedding.The expression of \u03b2-TrCP proteins was examined using LsAB(labelled streptavidin-biotin)method.Results \u03b2-TrCP proteins were expressed in the cytoplasm of the hair stems of hair follicle,hair cuticle,cuticle of root sheath,Huxley's layer of internal root sheath cells,external root sheath and mesenchymal tissues,but not in connective tissue sheath and Henle's layer of internal root sheath.Conclusion \u03b2-TrCP express in the developmental hair follicle tissues,which implicates that \u03b2-TrCP regulate the developmental hair follicle by mediating the signal transduction pathways.",
        "keywords": [
            "\u03b2-TrCP",
            "Hair follicle development",
            "Immunohistochemistry"
        ],
        "authors": [
            {
                "name": "SHEN Yong-dai",
                "org": ". State Key Laboratory of Oral Diseases,West China Stomatological Hospital,Sichuan University,Chengdu ,China"
            },
            {
                "name": "HE Yong-hong",
                "org": ". State Key Laboratory of Oral Diseases,West China Stomatological Hospital,Sichuan University,Chengdu ,China"
            },
            {
                "name": "YANG Lin",
                "org": ". State Key Laboratory of Oral Diseases,West China Stomatological Hospital,Sichuan University,Chengdu ,China"
            },
            {
                "name": "TANG Wei",
                "org": ". State Key Laboratory of Oral Diseases,West China Stomatological Hospital,Sichuan University,Chengdu ,China"
            },
            {
                "name": "LIU Lei",
                "org": ". State Key Laboratory of Oral Diseases,West China Stomatological Hospital,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Journal of Sichuan University(Medical Science Edition)",
        "year": 2008
    },
    "4DA2f8ub": {
        "id": "4DA2f8ub",
        "title": "Application of image-guided surgical navigation system in oral and maxillofacial surgery",
        "abstract": "Image-guided surgical navigation system which combines the technique of modern imaging, stereotatics, computer and artificial intelligent, has quickly developed and applied recently at home and abroad. This article reviewed concept, basic principle, development, application in oral and maxillofacial surgery, problems and prospect of image-guided surgical navigation system.",
        "keywords": [
            "computer assisted surgery",
            "minimally invasive surgery",
            "oral and maxillofacial sur-gery",
            "image-guided surgical navigation system"
        ],
        "authors": [
            {
                "name": "GAO Chao",
                "org": "Dept. of Traumatic and Plastic Surgery, West China College of Stomatology, SichuanUniversity, Chengdu , China"
            },
            {
                "name": "TANG Wei",
                "org": "Dept. of Traumatic and Plastic Surgery, West China College of Stomatology, SichuanUniversity, Chengdu , China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "Dept. of Traumatic and Plastic Surgery, West China College of Stomatology, SichuanUniversity, Chengdu , China"
            }
        ],
        "venue": "International Journal of Stomatology",
        "year": 2008
    },
    "kH4SP0xe": {
        "id": "kH4SP0xe",
        "title": "A study on repairing mandibular defect by means of tissue-engineering and human bone morphogenetic protein-2 gene transfection in osteoporotic rats]",
        "abstract": "To investigate the feasibility of repairing bone defect with methods of tissue-engineering and human bone morphogenetic protein-2 (hBMP-2) gene transfection in osteoporotic rats.Twenty-four 6-month-old female Sprague-Dawley rats underwent ovariectomy, while 8 rats received sham-operations. Three months later, bone mesenchymal stem cells (BMSC) harvested from osteoporotic rats were divided into two groups randomly. Experimental group were transfected by recombinant plasmid carrying hBMP-2 gene, and control group left untreated. All BMSC were seeded into coralhydroxyapatite scaffolds. Then the cell/scaffold constructs were implanted into the defect site created in the ramus of mandible of osteoporotic rats respectively.Positive results were confirmed by immunohistochemistry and in situ hybridization in experimental group. New bone formation was found at the margin of the defect treated with the BMSC modified by hBMP-2 gene transfer at 4 weeks after implantation and appeared mature 8 weeks after the treatment. However, the amount of newly formed bone was much less and there was some adipose tissue at defect margins 8 weeks after implantation in control group.The results of this experiment indicate that BMSC-mediated rhBMP-2 gene therapy in conjunction with bone tissue engineering may allow for successful treatment of large bone defects in osteoporosis rats.",
        "keywords": [
            "bone transplantation",
            "gene therapy",
            "steoporosis"
        ],
        "authors": [
            {
                "name": "You-chao Tang",
                "org": ". Department of Oral and Maxillofacial Surgery, Guangdong Province Huizhou Hospital of Stomatology, Huizhou Guangdong , China"
            },
            {
                "name": "Wei Tang",
                "org": ". Department of Oral and Maxillofacial Surgery, Guangdong Province Huizhou Hospital of Stomatology, Huizhou Guangdong , China"
            },
            {
                "name": "Wei-dong Tian",
                "org": ". Department of Oral and Maxillofacial Surgery, Guangdong Province Huizhou Hospital of Stomatology, Huizhou Guangdong , China"
            },
            {
                "name": "Xi-zhe Chen",
                "org": ". Department of Oral and Maxillofacial Surgery, Guangdong Province Huizhou Hospital of Stomatology, Huizhou Guangdong , China"
            },
            {
                "name": "Sheng-wei Li",
                "org": ". Department of Oral and Maxillofacial Surgery, Guangdong Province Huizhou Hospital of Stomatology, Huizhou Guangdong , China"
            }
        ],
        "venue": "Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology",
        "year": 2006
    },
    "iv9QL2aP": {
        "id": "iv9QL2aP",
        "title": "Expressions of fibronectin and bone morphogenetic protein-2, 4 during development of mouse tooth germ]",
        "abstract": "The purpose of this study was to investigate the distribution and relationship of fibronectin (FN), bone morphogenetic protein (BMP) 2, 4 during development of mouse tooth germ.Rat embryonic first molars were collected from E14 (bud stage) and E18 (bell stage). The expressions of FN and BMP-2, 4 were analyzed with immunohistochemistry.FN was located in the epithelium and dental mesenchyme on bud stage, but on bell stage, the FN was found at the region of differentiating odontoblasts and in the inner enamel epithelium, and also BMP-2, 4 were abundant mainly at the brisk region of differentiating odontoblasts.The results demonstrate that BMP-2, 4 and FN play the important roles during bud stage and bell stage, and there may be synergy between BMP-2, 4 and FN in regulating differentiation and maturity of odontoblasts.",
        "keywords": [
            "Bone morphogenetic protein",
            "Fibronectin",
            "Odontoblasts",
            "Tooth germ"
        ],
        "authors": [
            {
                "name": "Jian Zhang",
                "org": ".Department of Oral and Maxillofacial Surgery,West China Stomatological Hospital,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Wei-dong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xin Nie",
                "org": ".Department of Oral and Maxillofacial Surgery,West China Stomatological Hospital,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Lei Liu",
                "org": ".Department of Oral and Maxillofacial Surgery,West China Stomatological Hospital,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Yun-feng Lin",
                "org": ".Department of Oral and Maxillofacial Surgery,West China Stomatological Hospital,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition",
        "year": 2007
    },
    "jvBQIkaU": {
        "id": "jvBQIkaU",
        "title": "Application Research of Computer Assistant Biomedical Technology in Panfacial Fracture",
        "abstract": "The treatment of panfacial fracture is the most complex problem in maxillofacial surgery.Accurate fracture location plays a very important role in obtaining the best functional and cosmetic results;however,plain radiographs do not provide adequate information for a full evaluation.Advances of these,including three-dimension CT,reverse engineering/rapid prototyping and computed tomography based surgical navigation,were very rapid in recent years.Computer assistant biomedical technology can display the panfacial fracture dearly,accurately and stereoscopically and be helpful to both diagnosis and clinical managements. This article briefly introduced the research and development of biomedical technology based on computed tomographic data in the panfacial fracture.",
        "keywords": [
            "Bone fracture",
            "Computed Tomography",
            "Biomedicine",
            "Maxillofacial surgery"
        ],
        "authors": [
            {
                "name": "SHE Zhen-hua",
                "org": " Department of Stomatology,People's Hospital,Jinghong ,Yunnan,China; Department of stomatology,the 359th Hospital of PLA,Zhenjiang,Jiangsu ,China"
            },
            {
                "name": "HE An",
                "org": " Department of maxillofacial surgery,West China College of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "LIU Lei",
                "org": " Department of stomatology,the 359th Hospital of PLA,Zhenjiang,Jiangsu ,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": " Department of stomatology,the 359th Hospital of PLA,Zhenjiang,Jiangsu ,China"
            },
            {
                "name": "NIE Xin",
                "org": " Department of stomatology,the 359th Hospital of PLA,Zhenjiang,Jiangsu ,China"
            }
        ],
        "venue": "Progress in Modern Biomedicine",
        "year": 2007
    },
    "YL8c7Zci": {
        "id": "YL8c7Zci",
        "title": "Odontogenic potential of bone marrow mesenchymal stem cells.",
        "abstract": "This study aimed to investigate the odontogenic potential of bone marrow mesenchymal stem cells (BM-MSCs) for seeding in tooth regeneration.In this study, BM-MSCs were co-cultured with oral epithelial cells derived from rat embryos. Expression of the odontogenic genes Pax9, DMP1, and DSPP was detected by the reverse-transcription polymerase chain reaction (RT-PCR) technique. To further characterize the odontogenic potential of BM-MSCs, the gold standard in vivo transplantation system was used.The results revealed that Pax9, DMP1, and DSPP expression was detected by RT-PCR only after co-culture of BM-MSCs and oral epithelial cells derived from embryos age E11.5. Histological analyses of the BM-MSCs/epithelial cell mass demonstrated the presence of tooth-like structures.The series of experiments both in vitro and in vivo demonstrated that BM-MSCs can differentiate into functional odontoblast-like cells. This implies that BM-MSCs may become a novel source of cells for seeding in tooth regeneration research.",
        "keywords": [
            "mesenchymal stem cell"
        ],
        "authors": [
            {
                "name": "Zhi-Yong Li",
                "org": "Attending Surgeon, Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China."
            },
            {
                "name": "Ling Chen",
                "org": "Attending Doctor, Stomatology Centre of Shenzhen People\u2019s Hospital, The Second Affiliated Hospital of Jinan University, Shenzhen, China."
            },
            {
                "name": "Lei Liu",
                "org": "Adjunct Professor, Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Yun-Feng Lin",
                "org": "Resident, Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Sheng-Wei Li",
                "org": "Professor, Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Wei-Dong Tian",
                "org": ""
            }
        ],
        "venue": "Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons",
        "year": 2007
    },
    "ky7i6AZC": {
        "id": "ky7i6AZC",
        "title": "Maxillofacial injuries in the Wenchuan earthquake.",
        "abstract": "We retrospectively analyzed the characteristics and treatment of maxillofacial injuries in the patients who were victims of the Wenchuan earthquake on May 12, 2008 to improve the maxillofacial injuries database and provide reference on patients' treatment after earthquake.We investigated 2944 cases by talking with the patients during the first 1 and half months after the earthquake and analyzed the results.Of the 2944 patients, 419 (14%) patients had maxillofacial injuries (man:woman, 1:1.07; mean age, 41.3 years old). Approximately 52% of the patients were injured by pressure and burying. Soft tissue injuries (91%) were considerably more prevalent than facial fractures (14%) and dentoalveolar injuries (17%). Of the patients with facial fractures, the numbers of cases of midface fracture (32 patients) were similar to the number of lower face fractures (31 patients). The most vulnerable bone regions were nasal-orbital-ethmoid bone (58.6%) and zygomatic bone (51.7%). Three hundred sixty patients (86%) demonstrated associated injuries, of which extremity injuries were the most prevalent. Ninety-two patients (22%) had wound infections, but only four patients (1%) had a general infection. Of the patients with maxillofacial injuries, only 77 patients (18.4%) received prehospital treatment.Our analysis of the characteristics of maxillofacial injuries after the Wenchuan earthquake may improve our emergency treatment procedures in future disaster situations.",
        "keywords": [
            "injury characteristics",
            "maxillofacial injuries",
            "wenchuan earthquake"
        ],
        "authors": [
            {
                "name": "Rui Li",
                "org": ""
            },
            {
                "name": "Hang Wang",
                "org": ""
            },
            {
                "name": "Jingang Xiao",
                "org": ""
            },
            {
                "name": "Xiaojuan Yang",
                "org": ""
            },
            {
                "name": "Lijuan Guo",
                "org": ""
            },
            {
                "name": "Qi Lu",
                "org": ""
            },
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Jie Long",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            },
            {
                "name": "Xiaoyu Li",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "The Journal of trauma",
        "year": 2010
    },
    "jTWi74DA": {
        "id": "jTWi74DA",
        "title": "Effects of bone morphogenetic protein 2 gene therapy on new bone formation during mandibular distraction osteogenesis at rapid rate in rabbits.",
        "abstract": "We investigated the effect of recombinant human bone morphogenetic protein 2 (rhBMP-2) on new bone formation during rapid-rate mandibular distraction osteogenesis. We also explored the feasibility of using local BMP-2 gene therapy to compensate for bad callus formation caused by a rapid distraction rate.Bone marrow mesenchymal stem cells (MSCs) from Japanese rabbits were transfected with adenovirus (adv)-BMP-2. The right mandibles of the rabbits were distracted after corticotomy. The distraction rate in group A was 0.8 mm/d. The distraction rate in group B was 2.4 mm/d, and the distraction gap was injected with adv-lacZ-transfected bone marrow MSCs. The distraction rate in group C was 2.4 mm/d, and the distraction gap was injected with adv-BMP-2-transfected bone marrow MSCs. New generation bone tissue in the distraction gap was analyzed by plain radiograph examinations, microfocus computerized tomography (micro-CT) examinations, and biomechanical tests at weeks 2, 4, and 8 of the consolidation period.Radiographic and micro-CT examinations showed a better bone quality in group C compared with group A at weeks 2 and 4 of the consolidation period. There was no obvious new bone formation in group B. The trabecular parameters (trabecular thickness, trabecular number, volumetric bone mineral density at tissue, and bone volume fraction) were significantly higher in group C than in group A at weeks 2 and 4. At week 8, no significant difference were detected for all parameters except trabecular number between groups A and C. All biomechanical stress parameters were significantly higher in group C than in group A at week 4, and only peak stress was significantly different at week 8.Gene therapy using rhBMP-2-modified MSCs promoted new bone formation during mandibular distraction osteogenesis, and effectively compensated for the detrimental effect of rapid distraction rate on new bone formation.",
        "keywords": [
            "bone morphogenetic protein 2"
        ],
        "authors": [
            {
                "name": "Jie Long",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Peng Li",
                "org": "Department of Stomatology, Chengdu Children's Special Hospital, Chengdu, China"
            },
            {
                "name": "Hong-ming Du",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Lei Liu",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Xiao-hui Zheng",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Yun-feng Lin",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Hang Wang",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China"
            },
            {
                "name": "Wei Jing",
                "org": "State Key Laboratory of Oral Disease, Sichuan University, Chengdu, China"
            },
            {
                "name": "Wei Tang",
                "org": "State Key Laboratory of Oral Disease, Sichuan University, Chengdu, China"
            },
            {
                "name": "Wei-hui Chen",
                "org": "Department of Oral Surgery, Union Hospital, Fujian Medical University, Fuzhou, China"
            },
            {
                "name": "Wei-dong Tian",
                "org": ""
            }
        ],
        "venue": "Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics",
        "year": 2011
    },
    "LdV7XHVs": {
        "id": "LdV7XHVs",
        "title": "Effects of rapid distraction rate on new bone formation during mandibular distraction osteogenesis in goats.",
        "abstract": "Distraction osteogenesis typically requires a long treatment period, which can lead to bone and soft-tissue infection and considerable patient discomfort. Use of a rapid distraction rate in craniofacial distraction osteogenesis to shorten the distraction period is possible owing to the unique characteristics of craniofacial bones, including an abundant blood supply and rapid bone healing compared with long bones. The effects of using a rapid distraction rate in the treatment of craniofacial deformities are currently unclear, however. The objective of this study was to investigate the effects of a rapid distraction rate on new bone formation during mandibular distraction osteogenesis in goats.Sixteen goats were randomly divided into four groups consisting of four goats each. In Groups A, B, and C, the right mandible of each goat was distracted at a rate of 0.8mm/d, 1.6mm/d, and 2.0mm/d, respectively; Group D was the control group and did not undergo distraction. Six weeks after the conclusion of distraction, bone densitometry and three-point bending testing were performed in all groups.The mean bone density value of goats in Group A was significantly higher than those of all the other groups (p<0.05), and the mean bone density value of goats in Group C was significantly lower than those of all the other groups (p<0.05). The mean curve slope, peak stress, bending modulus, and energy to failure values of Groups A, B, and C were all significantly lower than those of the control group (p<0.05). As the distraction rate increased, the curve slope and peak stress values gradually declined (p<0.05).Use of a rapid distraction rate in mandibular distraction osteogenesis may have detrimental effects on the quality of new bone, despite the abundant blood supply of craniofacial bones.",
        "keywords": [
            "biomechanical strength",
            "bone densitometry",
            "distraction osteogenesis",
            "distraction rate",
            "soft tissue"
        ],
        "authors": [
            {
                "name": "Jie Long",
                "org": ""
            },
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Yu-bo Fan",
                "org": ""
            },
            {
                "name": "Wei-dong Tian",
                "org": ""
            },
            {
                "name": "Fan Feng",
                "org": ""
            },
            {
                "name": "Lei Liu",
                "org": ""
            },
            {
                "name": "Xiao-hui Zheng",
                "org": ""
            },
            {
                "name": "Wei Jing",
                "org": ""
            },
            {
                "name": "Ling Wu",
                "org": ""
            }
        ],
        "venue": "Injury",
        "year": 2009
    },
    "63ZMt6v4": {
        "id": "63ZMt6v4",
        "title": "Effect of miR-26a-5p on the Wnt/Ca(2+) Pathway and Osteogenic Differentiation of Mouse Adipose-Derived Mesenchymal Stem Cells.",
        "abstract": "Elucidation of the molecular mechanisms that regulate the differentiation of adipose-derived mesenchymal stem cells into osteogenic cells may lead to new methods for bone tissue engineering. We examined the role of miR-26a-5p in the regulation of osteogenic differentiation of mouse adipose-derived mesenchymal stem cells (mADSCs) by using mimics and inhibitors of this microRNA. Our results showed that over-expression of miR-26a-5p inhibited osteogenesis and that suppression of endogenous miR-26a-5p promoted osteogenesis. Four bioinformatics algorithms indicated that the 3'UTR of Wnt5a was a potential target of miR-26a-5p. We confirmed this prediction by use of dual-luciferase reporter assay and GFP/RFP assay. We also examined the molecular mechanisms by which miR-26a-5p regulates osteogenesis. Fura-2AM and Western blot assays after transfection indicated that miR-26a-5p repressed WNT5A, inhibited calcium flux and protein kinase C, and suppressed osteogenic differentiation of mADSCs. By contrast, miR-26a-5p inhibition activated these signal proteins and promoted osteogenic differentiation. Taken together, our results suggest that up-regulation of miR-26a-5p inhibits osteogenic differentiation of mADSCs by directly targeting the 3'UTR of Wnt5a, thereby down-regulating the Wnt/Ca(2+) signaling pathway. ",
        "keywords": [
            "Adipose-derived mesenchymal stem cell (ADSC)",
            "MicroRNA-26a-5p",
            "Non-canonical Wnt pathway",
            "Osteogenic differentiation",
            "WNT5A"
        ],
        "authors": [
            {
                "name": "Shasha Li",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Chen Hu",
                "org": "Department of Oral and Maxillofacial Surgery, General Hospital of Ningxia Medical University, Yinchuan, 750004, People's Republic of China."
            },
            {
                "name": "Jianwei Li",
                "org": "Department of Oral and Maxillofacial Surgery, Binzhou Medical University Hospital, Binzhou, 256603, People's Republic of China."
            },
            {
                "name": "Lei Liu",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Wei Jing",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Wei Tang",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Weidong Tian",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Jie Long",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China. dr.jielong@hotmail.com."
            }
        ],
        "venue": "Calcified tissue international",
        "year": 2016
    },
    "zWdx1E2M": {
        "id": "zWdx1E2M",
        "title": "Differential Expression Profiles of Circular RNAs During Osteogenic Differentiation of Mouse Adipose-Derived Stromal Cells.",
        "abstract": "Osteogenesis is a complex and tightly regulated process. Circular RNAs (circRNAs) are covalently closed RNA molecules which are thought to play a significant role in bone metabolism. The purpose of this study was to investigate the expression and putative function of circRNAs during the osteogenic differentiation of mouse adipose-derived stromal cells (mADSCs). circRNA microarrays were used to determine differential circRNAs expression at different stages during osteogenesis of mADSCs. The most frequent differentially expressed circRNAs were selected by Venn analysis and clustered among the three induced groups. In addition, bioinformatic analyses (gene ontology, pathway, and co-expression network analysis) were used to further investigate these differentially expressed circRNAs. A total of 14,236 circRNAs were detected, of which 43 circRNAs (40 upregulated) were consistently altered at indicated time points during osteogenic differentiation of mADSCs. The exonic circRNAs represented a significantly larger proportion among the differentially expressed circRNAs compared to other types of circRNAs. Gene ontology and Kyoto Encyclopedia of Genes and Genomes biological pathway analysis were performed to evaluate the functions of differentially expressed circRNAs during the osteogenic process. Our circRNA-miRNA co-expression network showed that miR-338-3p was correlated with upregulation of two circRNAs (mmu_circRNA_013422, mmu_circRNA_22566). Our data on circRNA expression profiles may provide valuable insight into circRNA function during osteogenic differentiation of mADSCs. Additionally, the circRNA-miRNA-mRNA pathways may provide information on novel mechanisms and targets for clinical investigations on bone formation and regeneration.",
        "keywords": [
            "Adipose-derived stromal cells",
            "Differentiation",
            "Expression profile",
            "Fat",
            "Osteogenesis",
            "circRNAs"
        ],
        "authors": [
            {
                "name": "Ting Long",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Zeyou Guo",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Lu Han",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Xiaoyan Yuan",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Lei Liu",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Wei Jing",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Weidong Tian",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Xiao-Hui Zheng",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Wei Tang",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Jie Long",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China. dr.jielong@hotmail.com."
            }
        ],
        "venue": "Calcified tissue international",
        "year": 2018
    },
    "Wl5ibWg3": {
        "id": "Wl5ibWg3",
        "title": "Application of computer-assisted surgery techniques in the management of zygomatic complex fractures",
        "abstract": "Abstract   Patients suffering from zygomatic complex fractures always present facial\u2006deformity and dysfunctions, and thereafter develop psychological and physiological problems. It is really hard to get an ideal prognosis for the zygomatic complex fractures because of the complicated anatomical structures. Computer-assisted surgery techniques, as the new emerging auxiliary methods, can optimize the surgical protocol, predict operation outcomes, and improve the accuracy and quality of the operation. Meanwhile the postoperative complications can be reduced effectively. This review aims to provide a comprehensive overview of the application of computer-assisted surgery techniques in the management of zygomatic complex fractures.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiao Zhang",
                "org": "Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"
            },
            {
                "name": "Chaoying Han",
                "org": "Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"
            },
            {
                "name": "Min-Jia Dai",
                "org": "Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"
            },
            {
                "name": "Jinlong Chen",
                "org": "Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"
            },
            {
                "name": "Xiaohui Zheng",
                "org": "Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"
            },
            {
                "name": "Jie Long",
                "org": "Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"
            },
            {
                "name": "Wei Tang",
                "org": "Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"
            },
            {
                "name": "Lei Liu",
                "org": "Department of Oral & Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China"
            }
        ],
        "venue": "Chinese journal of traumatology",
        "year": 2018
    },
    "TfMaT7E8": {
        "id": "TfMaT7E8",
        "title": "Analysis of maxillofacial fracture victims in the Wenchuan earthquake and Yushu earthquake: Maxillofacial fracture victims in two earthquakes",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weidong tian",
                "org": ""
            },
            {
                "name": "lei liu",
                "org": ""
            },
            {
                "name": "jie long",
                "org": ""
            },
            {
                "name": "wei tang",
                "org": ""
            },
            {
                "name": "lijuan guo",
                "org": ""
            },
            {
                "name": "hang wang",
                "org": ""
            },
            {
                "name": "rui li",
                "org": ""
            }
        ],
        "venue": "Dental Traumatology",
        "year": 2010
    },
    "xhgIUwqW": {
        "id": "xhgIUwqW",
        "title": "Analysis of maxillofacial fracture victims in the Wenchuan earthquake and Yushu earthquake.",
        "abstract": "To analyze retrospectively 419 patients after the Wenchuan earthquake and 46 after Yushu earthquake with maxillofacial fractures so as to provide reference on patients' treatment after an earthquake.We investigated 419 patients after Wenchuan earthquake and 46 after Yushu earthquake with maxillofacial fractures who were admitted to the West China Hospital of Stomatology and other 46 hospitals in 10 provinces.A total of 58 patients had maxillofacial fractures (13.8%) including 33 (56.9%) men and 25 (43.1%) women after the Wenchuan earthquake and 6 (13%) had maxillofacial fractures after Yushu earthquake. Most patients were injured by pressing or burying. The nasal-orbital-ethmoidal region was the most frequent site of the maxillofacial fracture (58.6% in the Wenchuan earthquake and 66.7% in the Yushu earthquake). The most prevalent pattern of maxillofacial fracture was multiple and/or comminuted fractures (87.9% in the Wenchuan earthquake and 100% in the Yushu earthquake). There were 48 (82.8%) patients with associated injuries, and the most common site was extremity injuries (58.6%) after Wenchuan earthquake. Few patients received adequate prehospital treatment, with bandages predominantly. Most patients (65.5% in the Wenchuan earthquake and 100% in the Yushu earthquake) underwent open reduction and rigid internal fixation. We failed to find any patients with generalized infection. However, all patients in our study presented the symptoms of post-traumatic stress disorder.We analyze the characteristics of maxillofacial fractures after the two earthquakes, so as to improve our medical emergency system when such disasters happen again.",
        "keywords": [],
        "authors": [
            {
                "name": "Rui Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Hang Wang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lijuan Guo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Jie Long",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Liu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Dental traumatology : official publication of International Association for Dental Traumatology",
        "year": 2010
    },
    "Z073Cbww": {
        "id": "Z073Cbww",
        "title": "Biomechanical evaluation of Le Fort I maxillary fracture plating techniques.",
        "abstract": "This study used a biomechanical model to examine fundamental questions about rigid plate fixation treatment for maxillary Le Fort I fractures. Specifically, we sought to elucidate the principal strain patterns generated in miniplates and bite force transducers secondary to all masticatory forces, as well as the amount of permanent deformations incurred due to these loading forces.Forty polyurethane synthetic maxillary and mandibular replicas were used to simulate the mandible and maxilla. Ten replicas were controls (group A). The other 30 were divided into 3 groups (10 each), according to the fixation techniques of 3, 2, and 1 miniplates each side (groups B-D), that were osteotomized in the Le Fort I fracture line on the maxilla. Different forces of masseter medial pterygoid, temporalis, and lateral pterygoid muscles were loaded onto the replicas to simulate different functional conditions (anterior incisor, premolar, and molar clenching). Rosette strain gauges were attached at predefined points on the plates and the bite force transducer to compare the stability and bite force of the different fixation methods for maxillary Le Fort I fractures.Statistically significant differences were found for the deformation of the plates among fixation techniques. The order of stability for each technique was: group B greater than group C greater than group D. In regard to bite force, no difference was found between those found with group A and group B (P > .05), whereas the bite forces of groups C and D were less than those of group A (P < .05).The fixation of 3 miniplates on each side provides sufficient stability and restores the bite force to the level of the intact maxilla. \"The ideal fixation\" with 2 miniplates on each side restores 90% of the bite force, and there were more deformations of the miniplates with the \"ideal fixation\" compared to those found with group B. Group D fixation produced the worst effects for the treatment of maxillary Le Fort I fractures with a weak bite force and insufficient stability.",
        "keywords": [],
        "authors": [
            {
                "name": "Hang Wang",
                "org": "Research Fellow, Key Laboratory of Biomedical Engineering, Department of Oral and Maxillofacial Surgery, West China Stomatology College, Sichuan University, Sichuan, China."
            },
            {
                "name": "Meng-Shi Chen",
                "org": "Professor, Key Laboratory of Biomedical Engineering, West China Stomatology College, Sichuan University, Sichuan, China."
            },
            {
                "name": "Yu-Bo Fan",
                "org": "Professor and Chairman, Key Laboratory of Biomedical Engineering, West China Stomatology College, Sichuan University, Sichuan, China."
            },
            {
                "name": "Wei Tang",
                "org": "Associate Professor, Department of Oral and Maxillofacial Surgery, West China Stomatology College, Sichuan University, Sichuan, China."
            },
            {
                "name": "Wei-Dong Tian",
                "org": ""
            }
        ],
        "venue": "Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons",
        "year": 2007
    },
    "pwR6mL9K": {
        "id": "pwR6mL9K",
        "title": "Three-Dimensional Planning in Maxillofacial Fracture Surgery: Computer-Aided Design/Computer-Aided Manufacture Surgical Splints by Integrating Cone Beam Computerized Tomography Images Into Multislice Computerized Tomography Images.",
        "abstract": "This study aimed to evaluate an innovative workflow for maxillofacial fracture surgery planning and surgical splint designing. The maxillofacial multislice computerized tomography (MSCT) data and dental cone beam computerized tomography (CBCT) data both were obtained from 40 normal adults and 58 adults who suffered fractures. The each part of the CBCT dentition image was registered into MSCT image by the use of the iterative closest point algorithm. Volume evaluation of the virtual splints that were designed by the registered MSCT images and MSCT images of the same object was performed. Eighteen patients (group 1) were operated without any splint. Twenty-one (group 2) and 19 patients (group 3) used the splints designed according to the MSCT images and registered MSCT images, respectively. The authors' results showed that the mean errors between the 2 models ranged from 0.53 to 0.92\u200amm and the RMS errors ranged from 0.38 to 0.69\u200amm in fracture patients. The mean errors between the 2 models ranged from 0.47 to 0.85\u200amm and the RMS errors ranged from 0.33 to 0.71\u200amm in normal adults. 72.22% patients in group 1 recovered occlusion. 85.71% patients in group 2, and 94.73% patients in group 3 reconstructed occlusion. There was a statistically significant difference between the MSCT images based splints' volume and the registered MSCT splints' volume in patients (P\u200a<0.05). The MSCT images based splints' volume was statistically significantly distinct from the registered MSCT splints' volume in normal adults (P\u200a<0.05). There was a statistically significant difference between the MSCT images based splints' volume and the registered MSCT splints' volume in patients and normal adults (P\u200a<0.05). The occlusion recovery rate of group 3 was better than that of group 1 and group 2. The way of integrating CBCT images into MSCT images for splints designing was feasible. The volume of the splints designed by MSCT images tended to be smaller than the splints designed by the integrated MSCT images. The patients operated with splints tended to regain occlusion. The patients who were operated with the splints which were designed according to registered MSCT images tended to get occlusal recovered. ",
        "keywords": "",
        "authors": [
            {
                "name": "Jiayin Ren",
                "org": "*Department of Oral and Maxillofacial Surgery, West China College of Stomatology \u2020State Key Laboratory of Oral Disease \u2021College of Computer Science \u00a7Department of Oral Radiology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China."
            },
            {
                "name": "Zhongwei Zhou",
                "org": ""
            },
            {
                "name": "Peng Li",
                "org": ""
            },
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Jixiang Guo",
                "org": ""
            },
            {
                "name": "Hu Wang",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "The Journal of craniofacial surgery",
        "year": 2016
    },
    "jlre7dPc": {
        "id": "jlre7dPc",
        "title": "Virtual facial reconstruction based on accurate registration and fusion of 3D facial and MSCT scans",
        "abstract": "ObjectivesAccurate registration and feasible fusion of a three-dimensional (3D) photorealistic surface images (captured using the FaceSCAN3D\u00ae Scientific Photo Lab) from multislice spiral computed tomography (MSCT) images is important to achieve optimal craniomaxillofacial surgery outcomes; thus, the aim of this work was to optimize this process.",
        "keywords": [
            "Image registration",
            " Craniomaxillofacial surgery",
            " Procrustes registration",
            " ICP algorithm",
            " Virtual face",
            " Bildregistrierung",
            " Kraniomaxillofaziale chirurgie",
            " Prokrustes-registrierung",
            " ICP-algorithmus",
            " Virtuelles gesicht"
        ],
        "authors": [
            {
                "name": "Zhongwei Zhou",
                "org": "Sichuan University"
            },
            {
                "name": "Peng Li",
                "org": "Sichuan University"
            },
            {
                "name": "Jiayin Ren",
                "org": "Sichuan University"
            },
            {
                "name": "Jixiang Guo",
                "org": "Sichuan University"
            },
            {
                "name": "Yongqing Huang",
                "org": "Ningxia Medical University"
            },
            {
                "name": "Weidong Tian",
                "org": "Sichuan University"
            },
            {
                "name": "Wei Tang",
                "org": "Sichuan University"
            }
        ],
        "venue": "Journal of Orofacial Orthopedics-fortschritte Der Kieferorthopadie",
        "year": 2016
    },
    "JTdDmtsT": {
        "id": "JTdDmtsT",
        "title": "Treated dentin matrix paste as a novel pulp capping agent for dentin regeneration.",
        "abstract": "Regenerating dentin and preserving pulp vitality are the two key targets for the treatment of dental pulp exposure. Calcium hydroxide (CH), the widely used capping agent, may induce potential tunnel defect in reparative dentin and cause inflammation or even necrosis in pulp tissues. This study aimed to produce a novel pulp capping agent with better bioactivities. Treated dentin matrix (TDM) paste (TDMP) was fabricated consisting of TDM powder and aqueous TDM extract. The chemical and biological characteristics of TDMP were investigated, and its effect on the odontogenic differentiation of dental pulp stem cells explored at gene and protein level; the therapeutic effect for pulp exposure in miniature swine was further verified. TDMP possessed better biocompatibility with neutral pH value, significantly promoted the proliferation of dental pulp stem cells, and enhanced the gene and protein expressions of alkaline phosphatase, bone sialoprotein, dentin sialoprotein etc., compared with CH. In vivo pulp capping using TDMP presented the formation of continuous reparative dentin bridge thicker and denser than CH group. Moreover, pulp tissues under TDMP capping sites showed relatively slight angiectasis than those induced by CH. TDMP could achieve both dentin regeneration and vital pulp conservation, and might serve as a feasible substitute for CH in dental pulp repair procedure. Copyright \u00a9 2017 John Wiley & Sons, Ltd.",
        "keywords": [
            "calcium hydroxide",
            "dental pulp capping",
            "dentin regeneration",
            "treated dentin matrix",
            "vital pulp conservation"
        ],
        "authors": [
            {
                "name": "Jinlong Chen",
                "org": "Departments of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Caiyun Cui",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Xiangchen Qiao",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Bo Yang",
                "org": "Departments of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Mei Yu",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weihua Guo",
                "org": "Departments of Pediatric Dentistry, West China School of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weidong Tian",
                "org": "Departments of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, China."
            }
        ],
        "venue": "Journal of tissue engineering and regenerative medicine",
        "year": 2017
    },
    "T0WQizVJ": {
        "id": "T0WQizVJ",
        "title": "Periodontal-Derived Mesenchymal Cell Sheets Promote Periodontal Regeneration in Inflammatory Microenvironment.",
        "abstract": "In this study, we investigated the periodontal regenerative potential of dental follicle cell (DFC) sheets and periodontal ligament cell (PDLC) sheets in the simulating inflammatory microenvironment of periodontitis, to confirm their regenerative potential for clinical application and explain the possible mechanism. The biological characteristics of DFC sheets and PDLC sheets were explored in lipopolysaccharide from Porphyromonas gingivalis (P. gingivalis LPS)-induced inflammation microenvironment in vitro, then cell sheets were transplanted into canine periodontal defects with experimental periodontitis in situ for 3 months. The results showed that P. gingivalis LPS greatly impaired the differentiation of PDLC sheets, whereas promoted gene expression of bone sialoprotein (BSP), osteopontin (OPN), and periostin (POSTN) in DFC sheets. LPS activated toll-like receptor 4 and NF-\u03baB p65 phosphorylation in PDLC sheets. In experimental periodontitis, new periodontal attachment could be obtained in both PDLC sheets and DFC sheets. However, the complete periodontal regeneration, including periodontal ligament-cementum complex structure was observed only in DFC sheet groups, which also showed more alveolar bone formation than PDLC sheets. These results suggest that DFC sheets were more effective for periodontal regeneration in chronic inflammatory microenvironment of periodontitis. It is probably because of their ability to adapt the inflammatory environment and strong capacity to promote periodontal regeneration. This approach provides a tangible pathway toward clinical translation.",
        "keywords": [
            "cell sheet",
            "inflammation",
            "periodontal regeneration",
            "periodontitis"
        ],
        "authors": [
            {
                "name": "Shujuan Guo",
                "org": "3 Department of Periodontics, West China Hospital of Stomatology, Sichuan University , Chengdu, P.R. China ."
            },
            {
                "name": "Jian Kang",
                "org": "4 Department of Periodontics, Tianjin Stomatological Hospital , Tianjin, P.R. China ."
            },
            {
                "name": "Baohui Ji",
                "org": "5 Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University , Chengdu, P.R. China ."
            },
            {
                "name": "Weihua Guo",
                "org": "6 Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University , Chengdu, P.R. China ."
            },
            {
                "name": "Yi Ding",
                "org": "3 Department of Periodontics, West China Hospital of Stomatology, Sichuan University , Chengdu, P.R. China ."
            },
            {
                "name": "Yafei Wu",
                "org": "3 Department of Periodontics, West China Hospital of Stomatology, Sichuan University , Chengdu, P.R. China ."
            },
            {
                "name": "Weidong Tian",
                "org": "6 Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University , Chengdu, P.R. China ."
            }
        ],
        "venue": "Tissue engineering. Part A",
        "year": 2017
    },
    "hC6tc6o8": {
        "id": "hC6tc6o8",
        "title": "Stem cells from human exfoliated deciduous teeth as an alternative cell source in bio-root regeneration.",
        "abstract": "A stem cell-mediated bioengineered tooth root (bio-root) has proven to be a prospective tool for the treatment of tooth loss. As shown in our previous studies, dental follicle cells (DFCs) are suitable seeding cells for the construction of bio-roots. However, the DFCs which can only be obtained from unerupted tooth germ are restricted. Stem cells from human exfoliated deciduous teeth (SHEDs), which are harvested much more easily through a minimally invasive procedure, may be used as an alternative seeding cell. In this case, we compared the odontogenic characteristics of DFCs and SHEDs in bio-root regeneration. : The biological characteristics of SHEDs and DFCs were determined . The cells were then induced to secrete abundant extracellular matrix (ECM) and form macroscopic cell sheets. We combined the cell sheets with treated dentin matrix (TDM) for subcutaneous transplantation into nude mice and orthotopic jaw bone implantation in Sprague-Dawley rats to further verify their regenerative potential. : DFCs exhibited a higher proliferation rate and stronger osteogenesis and adipogenesis capacities, while SHEDs displayed increased migration ability and excellent neurogenic potential. Both dental follicle cell sheets (DFCSs) and sheets of stem cells from human exfoliated deciduous teeth (SHEDSs) expressed not only ECM proteins but also osteogenic and odontogenic proteins. Importantly, similar to DFCSs/TDM, SHEDSs/TDM also successfully achieved the  regeneration of the periodontal tissues, which consist of periodontal ligament fibers, blood vessels and new born alveolar bone. : Both SHEDs and DFCs possessed a similar odontogenic differentiation capacity  and SHEDs were regarded as a prospective seeding cell for use in bio-root regeneration in the future.",
        "keywords": [
            "Bio-root",
            "Cell sheet",
            "Dental follicle cell",
            "Periodontal regeneration",
            "Stem cells from human exfoliated deciduous teeth",
            "Treated dentin matrix"
        ],
        "authors": [
            {
                "name": "Xueting Yang",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Yue Ma",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Weihua Guo",
                "org": "Department of Pedodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Bo Yang",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            }
        ],
        "venue": "Theranostics",
        "year": 2019
    },
    "D9f8CZ6t": {
        "id": "D9f8CZ6t",
        "title": "Treated dentin matrix particles combined with dental follicle cell sheet stimulate periodontal regeneration.",
        "abstract": "These results demonstrate the potential of using TDMP/DFCSs in periodontal regeneration.",
        "keywords": [
            "Cell sheet engineering",
            "Dental follicle cell",
            "Dentin matrix",
            "Periodontal regeneration"
        ],
        "authors": [
            {
                "name": "Hefeng Yang",
                "org": "Department of Dental Research, The Affiliated Stomatological Hospital of Kunming Medical University, Kunming, Yunnan 650500, PR China; National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Jie Li",
                "org": "Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, College of Stomatology, Chongqing Medical University, Chongqing 401147, PR China."
            },
            {
                "name": "Yu Hu",
                "org": "Department of Orthodontics, The Affiliated Stomatological Hospital of Kunming Medical University, Kunming, Yunnan 650031, PR China."
            },
            {
                "name": "Jingjing Sun",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Weihua Guo",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Hui Li",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Jinglong Chen",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Fangjun Huo",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Weidong Tian",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, Sichuan University, Chengdu 610041, PR China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China. Electronic address: drtwd@sina.com."
            },
            {
                "name": "Song Li",
                "org": "Department of Dental Research, The Affiliated Stomatological Hospital of Kunming Medical University, Kunming, Yunnan 650500, PR China. Electronic address: lisong59@sohu.com."
            }
        ],
        "venue": "Dental materials : official publication of the Academy of Dental Materials",
        "year": 2019
    },
    "zqoDEMlR": {
        "id": "zqoDEMlR",
        "title": "Xenogeneic Bio-Root Prompts the Constructive Process Characterized by Macrophage Phenotype Polarization in Rodents and Nonhuman Primates.",
        "abstract": "Tissue or organ regeneration using xenogeneic matrices is a promising approach to address the shortage of donor matrices for allotransplantation. Success of such approach has been demonstrated to correlate with macrophage-mediated fibrotic homeostasis and tissue remodeling. The previous studies have demonstrated that treated dentin matrix (TDM) could be a suitable bioactive substrate for allogeneic tooth root regeneration. This study constructed xenogeneic bioengineered tooth root (bio-root) via a combination of porcine TDM (pTDM) with allogeneic dental follicle cells (DFCs). Macrophage phenotypes are used to evaluate the remodeling process of xenogeneic bio-roots in vitro and in vivo. pTDM can facilitate odontoblast differentiation of human derived DFCs. Xenogeneic bio-roots in rat subcutaneous tissue prompt constructive response via M1 macrophage infiltration during early postimplantation stages and increase restorative M2 phenotype at later stages. After implantation of bio-roots into jaws of rhesus monkeys for six months, periodontal ligament-like fibers accompanied by macrophage polarization are observed, which are positive for COL-1, Periostin, \u03b2III-tubulin and display such structures as fibroblasts and blood vessels. The reconstructed bio-root possesses biomechanical properties for the dissipation of masticatory forces. These results support that xenogeneic bio-root could maintain fibrotic homeostasis during remodeling process and highlight the potential application of xenogeneic matrices in regenerative medicine.",
        "keywords": [
            "macrophage polarization",
            "tissue remodeling",
            "treated dentin matrix",
            "xenogeneic bioengineered tooth root (bio-root)"
        ],
        "authors": [
            {
                "name": "Hui Li",
                "org": "Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, 610041, China."
            },
            {
                "name": "Jingjing Sun",
                "org": "Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, 610041, China."
            },
            {
                "name": "Jie Li",
                "org": "Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, College of Stomatology, Chongqing Medical University, Chongqing, 401147, China."
            },
            {
                "name": "Hefeng Yang",
                "org": "Department of Dental Research, The Affiliated Stomatological Hospital of Kunming Medical University, Kunming, 650031, China."
            },
            {
                "name": "Xiangyou Luo",
                "org": "Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, 610041, China."
            },
            {
                "name": "Jinlong Chen",
                "org": "Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, 610041, China."
            },
            {
                "name": "Li Xie",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China."
            },
            {
                "name": "Fangjun Huo",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China."
            },
            {
                "name": "Tian Zhu",
                "org": "Department of Pediatric Dentistry, West China School of Stomatology, Sichuan University, Chengdu, 610041, China."
            },
            {
                "name": "Weihua Guo",
                "org": "Department of Pediatric Dentistry, West China School of Stomatology, Sichuan University, Chengdu, 610041, China."
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, 610041, China."
            }
        ],
        "venue": "Advanced healthcare materials",
        "year": 2017
    },
    "tjfgAPuC": {
        "id": "tjfgAPuC",
        "title": "A new method for non-destructive stripping of coatings on titanium substrates",
        "abstract": "Abstract   This work proposed a new method to prepare undamaged cross-sectional samples of coatings on titanium substrates. First, various kinds of coatings were fabricated on titanium substrates by electrochemical, chemical and physical methods. Then the coated samples were anodized in glycerol electrolyte containing NH 4 F (1\u00a0wt.%)\u00a0+\u00a0H 2 O (10\u00a0vol.%) at 50\u00a0V for 2\u00a0h, which resulted in coating detachment. Afterwards, coating cross-sectional samples were prepared with detached coating fragments and observed by scanning electron microscopy. The results showed that original internal microstructures of the coatings can be observed from the freshly-broken cross-sections, which might not be observed from samples prepared by existing methods. Finally, we concluded that it was the TiO 2  nanotube layer formed between the coating and titanium substrate that caused the coatingu0027s detachment. The new method may be promising in detection, removing or transfer of coatings on titanium substrates.",
        "keywords": "",
        "authors": [
            {
                "name": "Li Xie",
                "org": ""
            },
            {
                "name": "Weihua Guo",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China"
            },
            {
                "name": "Fangjun Huo",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China"
            },
            {
                "name": "Xingye Tong",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China"
            },
            {
                "name": "Yueting Wang",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China"
            },
            {
                "name": "Zhen Wan",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China"
            },
            {
                "name": "Weidong Tian",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China"
            }
        ],
        "venue": "Surface & Coatings Technology",
        "year": 2016
    },
    "9gqfVSSc": {
        "id": "9gqfVSSc",
        "title": "Three\u2010dimensional printing biotechnology for the regeneration of the tooth and tooth\u2010supporting tissues",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yue Ma",
                "org": "State Key Laboratory of Oral Diseases West China School of Stomatology, Sichuan University Chengdu People's Republic of China"
            },
            {
                "name": "Li Xie",
                "org": "State Key Laboratory of Oral Diseases West China School of Stomatology, Sichuan University Chengdu People's Republic of China"
            },
            {
                "name": "Bo Yang",
                "org": "State Key Laboratory of Oral Diseases West China School of Stomatology, Sichuan University Chengdu People's Republic of China"
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Diseases West China School of Stomatology, Sichuan University Chengdu People's Republic of China"
            }
        ],
        "venue": "Biotechnology and Bioengineering",
        "year": 2018
    },
    "Sjwj61PD": {
        "id": "Sjwj61PD",
        "title": "A novel method to fabricate organic-free superhydrophobic surface on titanium substrates by removal of surface hydroxyl groups",
        "abstract": "Abstract   Titanium (Ti) and its alloys have been extensively used for biomedical applications and surface wettability makes large differences during their applications. Especially, superhydrophobic surfaces with water contact angle (WCA)\u202fu003e\u202f150\u00b0 are under great interest and are now finding increased use in the biomedical arena. Up to now, most fabrication of superhydrophobic surface on Ti substrates would introduce external organics with low surface free energy (SFE), which could influence the intrinsic chemical components of Ti surface and face the risk of degradation when exposed for a long time. But it seems quite difficult to achieve superhydrophobic surfaces on Ti substrates without organic coating and few researches have been reported. Herein, a superhydrophobic Ti surface (WCA\u202f=\u202f151.9\u00b0) was successfully fabricated by a novel method including anodization, H 2 O 2  and aging treatment. During this procedure, no external organics with low SFE were introduced. Then surface topography and roughness, 3D morphology, wettability, crystalline structure and chemical components of the as-prepared samples were characterized. The as-prepared surface was coated with a TiO 2  layer, and exhibited a porous morphology with numbers of crater structures with roughness value (Ra) about 1.21\u202f\u03bcm. It was found the absorption of hydrocarbon and decrease of hydroxyl (OH) groups together changed the intrinsic wettability of Ti surface, where the removal of OH groups by H 2 O 2  and aging treatment played a critical role. The results indicated that surface micro-roughness and declined intrinsic wettability were responsible for the formation of superhydrophobicity. This novel method could achieve superhydrophobicity without changing the intrinsic properties of Ti/TiO 2  surface and would have great potential in biomedical applications.",
        "keywords": "",
        "authors": [
            {
                "name": "Hao Wu",
                "org": ""
            },
            {
                "name": "Li Xie",
                "org": ""
            },
            {
                "name": "Ruitao Zhang",
                "org": ""
            },
            {
                "name": "Yuan Tian",
                "org": ""
            },
            {
                "name": "Suru Liu",
                "org": ""
            },
            {
                "name": "Min He",
                "org": ""
            },
            {
                "name": "Chao Huang",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Applied Surface Science",
        "year": 2019
    },
    "ZJlYBM5l": {
        "id": "ZJlYBM5l",
        "title": "Fabrication of biomimetic resorption lacunae-like structure on titanium surface and its osteoblast responses",
        "abstract": "Abstract   Biomimetic specific surface structure could improve biological behaviors of specific cells and eventual tissue integration. Featuring titanium surface with structures resembling bone resorption lacunae (RL) can be a promising approach to improve the osteoblast responses and osseointegration of implants. As a most common used dental implant surface, sandblasting and acid etching (SLA) surface has micro-sized structures with dimensions similar to RL, but great differences exist when it comes to shape and contour. In this work, by anodizing titanium substrate in a novel HCOONa/CH 3 COONa electrolyte, RL-like crater structures were fabricated with highly similar size, shape and contour. Compared with SLA, it was much more similar to RL structure in shape and contour. Furthermore, through subsequent alkali-heat treatment, nano-sized structures that overlaid the whole surface were obtained, which further mimic undercuts features inside the RL. The as-prepared surface was consisted of crystalline titania and exhibited super-hydrophilicity with good stability.  In vitro  evaluation results showed that the surface could significantly improve adhesion, proliferation and differentiation of MG63 cells in comparison with SLA. This new method may be a promising candidate for biomimetic modification of titanium implant to promote osseointegration.",
        "keywords": "",
        "authors": [
            {
                "name": "Fangjun Huo",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China"
            },
            {
                "name": "Weihua Guo",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China"
            },
            {
                "name": "Hao Wu",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China"
            },
            {
                "name": "Yueting Wang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China"
            },
            {
                "name": "Gang He",
                "org": "College of Computer Science and Technology, Southwest University of Science and Technology, Mianyang, Sichuan 621010, China"
            },
            {
                "name": "Li Xie",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China"
            }
        ],
        "venue": "Applied Surface Science",
        "year": 2018
    },
    "9mh74JEL": {
        "id": "9mh74JEL",
        "title": "A further insight into coating-substrate interface of TiUnite implant by a novel coating detachment method",
        "abstract": "Abstract   This work reports the development of a novel method to treat a commercially TiUnite\u00ae implant to detach its tightly bonded surface oxide layer. The implant was anodized in a fluorine-containing electrolyte (usually for TiO 2  nanotubes preparation) at 50\u202fV for 2\u202fh, which resulted in detachment of the coating. High-quality coating cross-sectional samples were prepared with detached coating fragments. Both the exposed titanium substrate and the detached coating were analyzed by scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX). It was interesting to find that the coating-substrate interface exhibited a specific \u201cmortise-tenon\u201d anchorage structure. For comparison, focused ion beam (FIB) method was also conducted and the results revealed uneven bonding interface, specific internal pores distribution and varied coating thickness of the oxide coating. EDX results reported to existence of Ga +  ion in the coating after FIB treatment while the novel method would increase the O element content. The novel method gave a brand new angle for detection of TiUnite implant and enhanced the understanding of its coating-substrate interface features unprecedentedly. It provides a novel and economy method for research, development and evaluation of coated titanium-based implant.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhen Wan",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China"
            },
            {
                "name": "Ruitao Zhang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China"
            },
            {
                "name": "Li Xie",
                "org": ""
            },
            {
                "name": "Suru Liu",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China"
            },
            {
                "name": "Hao Wu",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China"
            },
            {
                "name": "Yuan Tian",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China"
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China"
            }
        ],
        "venue": "Surface & Coatings Technology",
        "year": 2018
    },
    "Sq7uGtWL": {
        "id": "Sq7uGtWL",
        "title": "A wear-resistant TiO 2 nanoceramic coating on titanium implants for visible-light photocatalytic removal of organic residues.",
        "abstract": "An effective treatment for peri-implantitis is to completely remove all the bacterial deposits from the contaminated implants, especially the organic residues, to regain biocompatibility and re-osseointegration, but none of the conventional decontamination treatments has achieve this goal. The photocatalytic activity of TiO coating on titanium implants to degrade organic contaminants has attracted researchers' attention recently. But a pure TiO coating only responses to harmful ultraviolet light. Additionally, the poor coating mechanical properties are unable to protect the coating integrity versus initial mechanical decontamination. To address these issues, a unique TiO nanoceramic coating was fabricated on titanium substrates through an innovative plasma electrolytic oxidation (PEO) based procedure, which showed a disordered layer with oxygen vacancies on the outmost part. As a result, the coating could decompose methylene blue, rhodamine B, and pre-adsorbed lipopolysaccharide (LPS) under visible light. Additionally, the coating showed two-fold higher hardness than untreated titanium and excellent wear resistance against steel decontamination instruments, which could be attributed to the specific micro-structure, including the densely packed nanocrystals and good metallurgical combination. Moreover, the in vitro response of MG63 cells confirmed that the coating had comparable biocompatibility and osteoconductivity to untreated titanium substrates. This study provides a unique coating technique as well as a photocatalytic cleaning strategy to enhance decontamination of titanium dental implants, which will favour the development of peri-implantitis treatments. Statement of significance The treatment of peri-implantitis is based on the complete removal of bacterial deposits, especially the organic residues, but conventional decontamination treatments are hard to achieve it. The photocatalytic activity of TiO coating on titanium implants to degrade organic contaminants provides a promising strategy for deeper decontamination, but its nonactivation to visible light and poor mechanical properties have limited its application. To address these issues, a unique TiO nanoceramic coating was fabricated on titanium substrates based on plasma electrolytic oxidation. The coating showed enhanced visible-light photocatalytic activity, excellent wear resistance and satisfied biocompatibility. Based on this functional coating, it is promising to develop a more efficient strategy for deep decontamination of implant surface, which will favour the development of peri-implantitis treatments.",
        "keywords": [
            "Decontamination",
            "Peri-implantitis",
            "Photocatalysis",
            "Plasma electrolytic oxidation",
            "Wear resistance"
        ],
        "authors": [
            {
                "name": "Hao Wu",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China."
            },
            {
                "name": "Li Xie",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address: samuel0121@163.com."
            },
            {
                "name": "Min He",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China."
            },
            {
                "name": "Ruitao Zhang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China."
            },
            {
                "name": "Yuan Tian",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China."
            },
            {
                "name": "Suru Liu",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China."
            },
            {
                "name": "Tao Gong",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China."
            },
            {
                "name": "Fangjun Huo",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China."
            },
            {
                "name": "Ting Yang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China."
            },
            {
                "name": "Qingyuan Zhang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China."
            },
            {
                "name": "Shujuan Guo",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China."
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address: drtwd@sina.com."
            }
        ],
        "venue": "Acta biomaterialia",
        "year": 2019
    },
    "NVRbv0v6": {
        "id": "NVRbv0v6",
        "title": "Proteomics Applications in Dental Derived Stem Cells.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jie Li",
                "org": "Chongqing Medical University College of Stomatology Chongqing China"
            },
            {
                "name": "Weidong Tian",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine; West China Hospital of Stomatology; Sichuan University; Chengdu China"
            },
            {
                "name": "Jinlin Song",
                "org": "Chongqing Medical University College of Stomatology Chongqing China"
            }
        ],
        "venue": "Journal of Cellular Physiology",
        "year": 2017
    },
    "PwH56cAZ": {
        "id": "PwH56cAZ",
        "title": "Isolation of Murine Adipose-Derived Stromal/Stem Cells Using an Explant Culture Method.",
        "abstract": "Adipose tissue provides valuable cell source for tissue engineering, regenerative medicine, and adipose tissue biology studies. The most widely used adipose-derived stromal/stem cells (ASCs) isolation protocol involves enzymatic digestion with collagenase. However, the yield of the method is poor even impossible to collect enough stromal vascular fraction (SVF) for expansion when the sample size is small, for instance only new born mice is available for cell culture. Here, we describe an efficient protocol for the isolation and expansion of ASCs using explant culture.",
        "keywords": [
            "Adipose-derived stromal/stem cells (ASCs)",
            "Collagenase",
            "Explant",
            "Mesenchymal stem cells (MSCs)",
            "Murine"
        ],
        "authors": [
            {
                "name": "Jie Li",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Hui Li",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weidong Tian",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China. drtwd@sina.com."
            }
        ],
        "venue": "Methods in molecular biology (Clifton, N.J.)",
        "year": 2018
    },
    "mFmI8Lmu": {
        "id": "mFmI8Lmu",
        "title": "GSK3\u03b2 regulates ameloblast differentiation via Wnt and TGF-\u03b2 pathways.",
        "abstract": "Wnt and TGF-\u03b2 signaling pathways participate in regulating a variety of cell fates during organogenesis, including tooth development. Despite well-documented, the specific mechanisms, especially how these two pathways act coordinately in regulating enamel development, remain unknown. In this study, we identified Glycogen Synthase Kinase 3 beta (GSK3\u03b2), a negative regulator of Wnt signal pathway, participated in ameloblast differentiation via Wnt and TGF-\u03b2 pathways during enamel development. In vitro rat mandible culture treated with specific GSK3\u03b2 inhibitor SB415286 displayed enamel defects, accompanied by disrupted ameloblasts polarization, while odontoblasts and dentin appeared to be unaffected. Moreover, after GSK3\u03b2 knockdown by lentivirus-mediated RNA silencing, HAT-7 cells displayed abnormal cell polarity and cell adhesion, and failed to synthesize appreciable amounts of ameloblast-specific proteins. More importantly, inactivation of GSK3\u03b2 caused upregulated Wnt and downregulated TGF-\u03b2 pathway, while reactivation of TGF-\u03b2 signaling or suppression of Wnt signaling partially rescued the differentiation defects of ameloblasts caused by the GSK3\u03b2 knock-down. Taken together, these results suggested that GSK3\u03b2 was essential for ameloblasts differentiation, which might be indirectly mediated through Wnt and TGF-\u03b2 signaling pathways. This article is protected by copyright. All rights reserved.",
        "keywords": [
            "GSK3\u03b2",
            "TGF-\u03b2",
            "Wnt",
            "ameloblast differentiation",
            "ameloblast polarity",
            "enamel defects"
        ],
        "authors": [
            {
                "name": "Yaling Yang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Ziyue Li",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Guoqing Chen",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Jie Li",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Hui Li",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Mei Yu",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weiping Zhang",
                "org": "Lanzhou Hospital of Stomatology, No. 62, GaoLan Road, Lanzhou 730000, Gansu Province, China."
            },
            {
                "name": "Weihua Guo",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            }
        ],
        "venue": "Journal of cellular physiology",
        "year": 2017
    },
    "QryYHOYa": {
        "id": "QryYHOYa",
        "title": "Potential of human dental stem cells in repairing the complete transection of rat spinal cord.",
        "abstract": "Dental stem cells presented remarkable tissue regenerative capability after spinal cord injury through immunomodulatory, differentiation and protection capacity.",
        "keywords": "",
        "authors": [
            {
                "name": "Chao Yang",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People's Republic of China. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People's Republic of China."
            },
            {
                "name": "Xinghan Li",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People\u2019s Republic of China"
            },
            {
                "name": "Liang Sun",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People\u2019s Republic of China"
            },
            {
                "name": "Weihua Guo",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People\u2019s Republic of China"
            },
            {
                "name": "Weidong Tian",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, People\u2019s Republic of China"
            }
        ],
        "venue": "Journal of neural engineering",
        "year": 2017
    },
    "tUF9dx8p": {
        "id": "tUF9dx8p",
        "title": "Comparative study on differentiation of cervical-loop cells and Hertwig's epithelial root sheath cells under the induction of dental follicle cells in rat.",
        "abstract": "Cervical loop cells (CLC) and Hertwig's epithelial root sheath (HERS) cells are believed to play critical roles in distinct developmental patterns between rodent incisors and molars, respectively. However, the differences in differentiation between CLC and HERS cells, and their response to inductions from dental follicle cells, remain largely unknown. In present study, CLC and HERS cells, as well as incisor dental follicle (IF) cells and molar dental follicle (MF) cells were isolated from post-natal 7-day rats. IF and MF cell derived conditioned medium (CM) was obtained for induction of CLC and HERS cells. In vitro experiments, we found that, under the induction of dental follicle cell derived CM, CLC cells maintained the epithelial polygonal-shapes and formed massive minerals, while part of HERS cells underwent shape transformation and generated granular minerals. CLC cells expressed higher enamel-forming and mineralization related genes, while HERS cells showed opposite expression patterns of BMP2, BMP4, AMBN and AMGN. In vivo, CLC cells generated enamel-like tissues while HERS cells formed cementum-periodontal ligament-like structures. Taken together, CLC and HERS cells present distinct differentiation patterns under the inductions from dental follicle cells.",
        "keywords": "",
        "authors": [
            {
                "name": "Yongwen Guo",
                "org": "Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P.R. China."
            },
            {
                "name": "Weihua Guo",
                "org": "Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China."
            },
            {
                "name": "Jie Chen",
                "org": "Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P.R. China."
            },
            {
                "name": "Ye Tian",
                "org": "Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P.R. China."
            },
            {
                "name": "Guoqing Chen",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P.R. China."
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P.R. China. drtwd@sina.com."
            },
            {
                "name": "Ding Bai",
                "org": "Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, P.R. China. baiding@scu.edu.cn."
            }
        ],
        "venue": "Scientific reports",
        "year": 2018
    },
    "3ZNCPn6w": {
        "id": "3ZNCPn6w",
        "title": "Are Hertwig's epithelial root sheath cells necessary for periodontal formation by dental follicle cells?",
        "abstract": "Hertwig's epithelial root sheath cells directly participate in the formation of the periodontium, and they are essential for the differentiation of dental follicle cells to form periodontal structures. The combination use of Hertwig's epithelial root sheath cells and dental follicle cells is a promising approach for periodontal regeneration.",
        "keywords": [
            "Dental follicle cells",
            "Epithelial-mesenchymal interaction",
            "Hertwig\u2019s epithelial root sheath",
            "Periodontal regeneration"
        ],
        "authors": [
            {
                "name": "Yongwen Guo",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Weihua Guo",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, PR China."
            },
            {
                "name": "Jie Chen",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Guoqing Chen",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China."
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu 610041, PR China. Electronic address: drtwd@sina.com."
            },
            {
                "name": "Ding Bai",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China; Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu 610041, PR China. Electronic address: baiding@scu.edu.cn."
            }
        ],
        "venue": "Archives of oral biology",
        "year": 2018
    },
    "44Z0shfE": {
        "id": "44Z0shfE",
        "title": "Periodontitis contributes to adipose tissue inflammation through the NF-<kappa>B, JNK and ERK pathways to promote insulin resistance in\u00a0a\u00a0rat model.",
        "abstract": "This study aimed to investigate the mechanism by which periodontitis affects the inflammatory response and systemic insulin resistance in the white adipose and liver tissues in an obese rat model. The obese model was generated by feeding rats a high fat diet. The periodontitis model was induced by ligatures and injection of \"red complex\", which consisted of Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia, for two weeks. When compared with rats without periodontitis, fasting glucose levels and homeostasis model assessment index were significantly increased in rats with periodontitis, suggesting that periodontitis promotes the development of insulin resistance in obese rats. Gene and protein expression analysis in white adipose and liver tissue revealed that experimental periodontitis stimulated the expression of inflammatory cytokines, such as tumor necrosis factors-alpha, interleukin-1 beta, toll-like receptor 2 and toll-like receptor 4. Signals associated with inflammation and insulin resistance, including nuclear factor-<kappa> B, c-Jun amino-terminal kinase and extracellular-signal regulated kinase were significantly activated in the white adipose tissue from obese rats with periodontitis compared to obese rats without periodontitis. Taken together, these findings suggest that periodontitis plays an important role in aggravating the development of local white adipose inflammation and systemic insulin resistance in rat models.",
        "keywords": [
            "Inflammation",
            "Insulin resistance",
            "Porphyromonas gingivalis",
            "Rats",
            "Tannerella forsythia",
            "Treponema denticola"
        ],
        "authors": [
            {
                "name": "Yanli Huang",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China."
            },
            {
                "name": "Jin Zeng",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China."
            },
            {
                "name": "Guoqing Chen",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China."
            },
            {
                "name": "Xudong Xie",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China; Department of Periodontal Department, West China School of Stomatology, Sichuan University, No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China."
            },
            {
                "name": "Weihua Guo",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China; Department of Pediatric Pedodontics Dentistry, West China School of Stomatology, Sichuan University, No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China. Electronic address: guoweihua943019@163.com."
            },
            {
                "name": "Weidong Tian",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China; Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, No. 14, 3rd Section, Ren Min Nan Road, Wuhou District, Chengdu 610041, China. Electronic address: drtwd@sina.com."
            }
        ],
        "venue": "Microbes and infection",
        "year": 2016
    },
    "1QKsQwGn": {
        "id": "1QKsQwGn",
        "title": "Bcl11b regulates enamel matrix protein expression and dental epithelial cell differentiation during rat tooth development.",
        "abstract": "Amelogenesis, beginning with thickened epithelial aggregation and ending with highly mineralized enamel formation, is a process mediated by a complex signaling network that involves several molecules, including growth and transcription factors. During early tooth development, the transcription factor B\u2011cell\u00a0CLL/lymphoma\u00a011B (Bcl11b) participates in dental epithelial cell proliferation and differentiation. However, whether it affects the postnatal regulation of enamel matrix protein expression and ameloblast differentiation remains unclear. To clarify the role of Bcl11b in enamel development, the present study initially detected the protein expression levels of Bcl11b during tooth development using immunohistochemistry, from the embryonic lamina stage to the postnatal period, and demonstrated that Bcl11b is predominantly restricted to cervical loop epithelial cells at the cap and bell stages, whereas expression is reduced in ameloblasts. Notably, the expression pattern of Bcl11b during tooth development differed between rats and mice. Knockdown of Bcl11b by specific small interfering RNA attenuated the expression of enamel\u2011associated genes, including amelogenin, X\u2011linked (Amelx), ameloblastin (Ambn), enamelin (Enam), kallikrein related peptidase\u00a04 (Klk4), matrix metallopeptidase\u00a020 and Msh homeobox\u00a02 (Msx2). Chromatin immunoprecipitation assay verified that Msx2 was a transcriptional target of Bcl11b. However, overexpression of Msx2 resulted in downregulation of enamel\u2011associated genes, including Ambn, Amelx, Enam and Klk4. The present study suggested that Bcl11b serves a potentially important role in the regulation of ameloblast differentiation and enamel matrix protein expression. In addition, a complex feedback regulatory network may exist between Bcl11b and Msx2.",
        "keywords": "",
        "authors": [
            {
                "name": "Ziyue Li",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Guoqing Chen",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Yaling Yang",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Weihua Guo",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Weidong Tian",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            }
        ],
        "venue": "Molecular medicine reports",
        "year": 2017
    },
    "gqkTaVkk": {
        "id": "gqkTaVkk",
        "title": "Maternal diabetes modulates offspring cell proliferation and apoptosis during odontogenesis via the TLR4/NF-\u03baB signalling pathway.",
        "abstract": "Maternal gestational diabetes significantly impaired dental epithelial and mesenchymal cell proliferation and apoptosis in offspring, possibly by activation of the TLR4/NF-\u0138B signalling pathway.",
        "keywords": [
            "TLR4/NF-\u0138B signalling",
            "apoptosis",
            "cell proliferation",
            "maternal diabetes",
            "tooth development"
        ],
        "authors": [
            {
                "name": "Guoqing Chen",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China College of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Wenhua Sun",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China College of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Yan Liang",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Tian Chen",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China College of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weihua Guo",
                "org": "Department of Pedodontics, West China College of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China."
            }
        ],
        "venue": "Cell proliferation",
        "year": 2017
    },
    "qnZ5PYyH": {
        "id": "qnZ5PYyH",
        "title": "Schwann cells secrete extracellular vesicles to promote and maintain the proliferation and multipotency of hDPCs.",
        "abstract": "In summary, our study sheds light on critical regulatory ability of SC-derived EVs on hDPCs proliferation and multipotency, suggesting great implications for seeding cells used in tissue engineering.",
        "keywords": "",
        "authors": [
            {
                "name": "Ziyue Li",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Yan Liang",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Kuangwu Pan",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Hui Li",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Mei Yu",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weihua Guo",
                "org": "Department of Pedodontics, West China College of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Guoqing Chen",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            }
        ],
        "venue": "Cell proliferation",
        "year": 2017
    },
    "1zyeFJfk": {
        "id": "1zyeFJfk",
        "title": "Development of immortalized Hertwig's epithelial root sheath cell lines for cementum and dentin regeneration.",
        "abstract": "We successfully isolated and characterized novel cell lines representing two key features of HERS cells during the tooth root development and which were useful substitutes for primary HERS cells, thereby providing a biologically relevant, unlimited cell source for studies on cell biology, developmental biology, and tooth root regeneration.",
        "keywords": [
            "Cementum",
            "Dentin",
            "Hertwig\u2019s epithelial root sheath",
            "Tooth regeneration"
        ],
        "authors": [
            {
                "name": "Xuebing Li",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Sicheng Zhang",
                "org": "National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Zirui Zhang",
                "org": "West China School of Public Health, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weihua Guo",
                "org": "Department of Pediatric, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Guoqing Chen",
                "org": "National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. chen21gq@163.com."
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China. drtwd@sina.com."
            }
        ],
        "venue": "Stem cell research & therapy",
        "year": 2019
    },
    "NQmOpQli": {
        "id": "NQmOpQli",
        "title": "Prediabetes Enhances Periodontal Inflammation Consistent With Activation of Toll-Like Receptor\u2013Mediated Nuclear Factor-\u03baB Pathway in Rats",
        "abstract": "Background: Clinical studies have showed that prediabetes (preDM) is a predisposing factor for periodontitis. However, the pathogenic mechanism involved is unclear. Because it is known that the activation of Toll-like receptor (TLR)-mediated nuclear factor-kappa B (NF-\u03baB) signaling pathway plays a crucial role in periodontitis, it is hypothesized that preDM enhances periodontal inflammation by activation of the TLR-mediated NF-\u03baB pathway.Methods: In this study, a preDM rat model is established by feeding a high-fat diet (HFD). HFD-induced rats with preDM (n = 7) and normal chow\u2013fed rats (n = 7) were studied. The animal model was characterized in terms of body weight and the glycemic and insulinemic profiles. The following parameters were assessed to evaluate possible early periodontal alterations and underlying mechanisms: 1) histology analysis of periodontal tissue; and 2) serum and mRNA levels and/or the tissue protein expression of TLRs, myeloid differentiation factor 88 (MyD88), tumor necrosis factor ...",
        "keywords": "",
        "authors": [
            {
                "name": "Yanli Huang",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weihua Guo",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Jin Zeng",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Guoqing Chen",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Wenhua Sun",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Xuexin Zhang",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weidong Tian",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            }
        ],
        "venue": "Journal of Periodontology",
        "year": 2016
    },
    "nCZhl5rO": {
        "id": "nCZhl5rO",
        "title": "Effect of canonical NF-\u03baB signaling pathway on the differentiation of rat dental epithelial stem cells.",
        "abstract": "These results indicate that the canonical NF-\u03baB signaling pathway participated in the regulation of DESC differentiation, which was through upregulating SMAD7 expression and further suppressing the canonical TGF-\u03b2-SMAD signaling pathway.",
        "keywords": [
            "Amelogenesis",
            "Dental epithelial stem cell",
            "Differentiation",
            "NF-\u03baB",
            "TGF-\u03b2"
        ],
        "authors": [
            {
                "name": "Yan Liang",
                "org": "Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Guoqing Chen",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Yuzhi Yang",
                "org": "Department of Pediatric Dentistry, West China College of Stomatology, Sichuan University, No.14, 3rd Section, Renmin South Road, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Ziyue Li",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Tian Chen",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Wenhua Sun",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Mei Yu",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Kuangwu Pan",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, No.14, 3rd Section, Renmin South Road, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Weihua Guo",
                "org": "Department of Pediatric Dentistry, West China College of Stomatology, Sichuan University, No.14, 3rd Section, Renmin South Road, Chengdu, 610041, People's Republic of China. guoweihua943019@163.com."
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, No.14, 3rd Section, Renmin South Road, Chengdu, 610041, People's Republic of China. drtwd@sina.com."
            }
        ],
        "venue": "Stem cell research & therapy",
        "year": 2019
    },
    "XmXf9MEE": {
        "id": "XmXf9MEE",
        "title": "Comparison of human dental follicle cells and human periodontal ligament cells for dentin tissue regeneration.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ye tian",
                "org": ""
            },
            {
                "name": "ding bai",
                "org": ""
            },
            {
                "name": "weihua guo",
                "org": ""
            },
            {
                "name": "jie li",
                "org": ""
            },
            {
                "name": "jin zeng",
                "org": ""
            },
            {
                "name": "longqiang yang",
                "org": ""
            },
            {
                "name": "zongting jiang",
                "org": ""
            },
            {
                "name": "lian feng",
                "org": ""
            },
            {
                "name": "mei yu",
                "org": ""
            },
            {
                "name": "weidong tian",
                "org": ""
            }
        ],
        "venue": "Regenerative Medicine",
        "year": 2015
    },
    "bti9N7vG": {
        "id": "bti9N7vG",
        "title": "Tumorigenicity Analysis of Heterogeneous Dental Stem Cells and Its Self-Modification for Chromosome Instability",
        "abstract": "",
        "keywords": [
            "heterogeneity",
            "cin"
        ],
        "authors": [
            {
                "name": "zhaosong meng",
                "org": ""
            },
            {
                "name": "guoqing chen",
                "org": ""
            },
            {
                "name": "jinlong chen",
                "org": ""
            },
            {
                "name": "bo yang",
                "org": ""
            },
            {
                "name": "mei yu",
                "org": ""
            },
            {
                "name": "lian feng",
                "org": ""
            },
            {
                "name": "zongting jiang",
                "org": ""
            },
            {
                "name": "weihua guo",
                "org": ""
            },
            {
                "name": "weidong tian",
                "org": ""
            }
        ],
        "venue": "Cell Cycle",
        "year": 2015
    },
    "4PAC9knE": {
        "id": "4PAC9knE",
        "title": "Cytoskeletal Binding Proteins Distinguish Cultured Dental Follicle Cells and Periodontal Ligament Cells",
        "abstract": "",
        "keywords": [
            "cytoskeleton",
            "proteome",
            "stem cells",
            "tissue regeneration"
        ],
        "authors": [
            {
                "name": "jie li",
                "org": ""
            },
            {
                "name": "hui li",
                "org": ""
            },
            {
                "name": "ye tian",
                "org": ""
            },
            {
                "name": "yaling yang",
                "org": ""
            },
            {
                "name": "guoqing chen",
                "org": ""
            },
            {
                "name": "weihua guo",
                "org": ""
            },
            {
                "name": "weidong tian",
                "org": ""
            }
        ],
        "venue": "Experimental Cell Research",
        "year": 2015
    },
    "kvGuvdLS": {
        "id": "kvGuvdLS",
        "title": "Disruption of kif3a results in defective osteoblastic differentiation in dental mesenchymal stem/precursor cells via the Wnt signaling pathway.",
        "abstract": "The anterograde intraflagellar transport motor protein, kif3a, regulates the integrity of primary cilia and various cellular functions, however, the role of kif3a in dental mesenchymal stem/precursor cell differentiation remains to be fully elucidated. In the present study, the expression of kif3a was knocked down in human dental follicle cells (hDFCs) and human dental pulp cells (hDPCs) using short hairpin\u00a0RNA. The results of subsequent immunofluorescence revealed that knocking down kif3a resulted in the loss of primary cilia, which led to impairment of substantial mineralization and expression of the differentiation\u2011associated markers, including alkaline phosphatase, Runt\u2011related transcription factor\u00a02, dentin matrix protein\u00a01 and dentin sialophosphoprotein in the hDFCs and hDPCs. The results of reverse transcription\u2011quantitative polymerase chain reaction and western blot analyses showed that the expression levels of Wnt3a\u2011mediated active \u03b2\u2011catenin and lymphoid enhancer\u2011binding factor\u00a01 were attenuated, whereas the expression of phosphorylated glycogen synthase kinase\u00a03\u03b2 was enhanced, in the kif3a\u2011knockdown cells. In addition, exogenous Wnt3a partially rescued osteoblastic differentiation in the hDFCs and hDPCs. These results demonstrated that inhibition of kif3a in the hDFCs and hDPCs disrupted primary cilia formation and/or function, and indicated that kif3a is important in the differentiation of hDFCs and hDPCs through the Wnt pathway. These findings not only enhance current understanding of tooth development and diseases of tooth mineralization, but also indicate possible strategies to regulate mineralization during tooth repair and regeneration. ",
        "keywords": "",
        "authors": [
            {
                "name": "Sicong Jiang",
                "org": "School of Life Sciences and Key Laboratory of Bio\u2011Resources and Eco\u2011Environment, Ministry of Education, Sichuan University, Chengdu, Sichuan 610064, P.R. China."
            },
            {
                "name": "Guoqing Chen",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Lian Feng",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Zongting Jiang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Mei Yu",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Jinku Bao",
                "org": "School of Life Sciences and Key Laboratory of Bio\u2011Resources and Eco\u2011Environment, Ministry of Education, Sichuan University, Chengdu, Sichuan 610064, P.R. China."
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            }
        ],
        "venue": "Molecular medicine reports",
        "year": 2016
    },
    "wVjvuyrf": {
        "id": "wVjvuyrf",
        "title": "Botulinum toxin A improves adipose tissue engraftment by promoting cell proliferation, adipogenesis and angiogenesis.",
        "abstract": "Adipose tissue engraftment has become a well-established therapy in plastic and reconstructive surgery used to restore age-related or injury-related soft tissue loss. However, the unpredictable absorption rates limit its further application. Some clinicians have noted that more optimal aesthetic results are achieved when botulinum toxin\u00a0A\u00a0(BoNTA) is applied prior to adipose tissue grafting. In the present study, we transplanted allogeneic adipose tissue treated with or without BoNTA in SD rats in\u00a0vivo. We subsequently evaluated the survival rate\u00a0(weight, volume, apoptosis and cellular integrity) and revascularization of the adipose tissue. The results revealed that BoNTA improved the long-term weight and volume retention of the graft, and preserved cellular integrity. BoNTA significantly increased the expression levels of CD31 and vascular endothelial growth factor\u00a0(VEGF), suggesting enhanced vasodilation and endothelial cell proliferation. In\u00a0vitro, adipose-derived stem cells\u00a0(ASCs) were isolated, identified and induced to proliferate and differentiate with or without BoNTA. Furthermore, to evaluate the proliferative, adipogenic and angiogenic ability of the ASCs, CCK-8 assay and Oil\u00a0Red\u00a0O staining were conducted. Gene and protein expression levels were analyzed by RT-qPCR and western blot analysis. The results revealed that 8x10-2\u00a0U/ml BoNTA as the optimal dose increased ASC proliferation and adipogenic differentiation capacity, as well as the expression level of the key cytokine of angiogenesis. On the whole, our findings indicate that BoNTA improves adipose tissue engraftment and promotes ASC regeneration, which could benefit future clinical applications.",
        "keywords": "",
        "authors": [
            {
                "name": "Qi Tang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R.\u00a0China."
            },
            {
                "name": "Chang Chen",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R.\u00a0China."
            },
            {
                "name": "Xiaqi Wang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R.\u00a0China."
            },
            {
                "name": "Wei Li",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R.\u00a0China."
            },
            {
                "name": "Yan Zhang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R.\u00a0China."
            },
            {
                "name": "Muyao Wang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R.\u00a0China."
            },
            {
                "name": "Wei Jing",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R.\u00a0China."
            },
            {
                "name": "Hang Wang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R.\u00a0China."
            },
            {
                "name": "Weihua Guo",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R.\u00a0China."
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, P.R.\u00a0China."
            }
        ],
        "venue": "International journal of molecular medicine",
        "year": 2017
    },
    "ojp5vZd4": {
        "id": "ojp5vZd4",
        "title": "Physioxia: a more effective approach for culturing human adipose-derived stem cells for cell transplantation.",
        "abstract": "These results suggest that physioxia is a more effective environment in which to culture ASCs for transplantation owing to the maintenance of native bioactivities without injury by hyperoxia.",
        "keywords": [
            "Adipose-derived stem cells",
            "Cell survival",
            "Cell therapy",
            "Culture approach",
            "Physioxia"
        ],
        "authors": [
            {
                "name": "Chang Chen",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, People's Republic of China."
            },
            {
                "name": "Qi Tang",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, People's Republic of China."
            },
            {
                "name": "Yan Zhang",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, People's Republic of China."
            },
            {
                "name": "Mei Yu",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, People's Republic of China."
            },
            {
                "name": "Wei Jing",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, People's Republic of China. jingwei@scu.edu.cn."
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, People's Republic of China. drtwd@sina.com."
            }
        ],
        "venue": "Stem cell research & therapy",
        "year": 2018
    },
    "kdVezk6c": {
        "id": "kdVezk6c",
        "title": "Exosome-Like Vesicles Derived from Adipose Tissue Provide Biochemical Cues for Adipose Tissue Regeneration.",
        "abstract": "There is an emerging need for soft tissue replacements in the field of reconstructive surgery for the treatment of congenital deformities, posttraumatic repair, and cancer rehabilitation. Previous studies have shown that the bioactive adipose tissue extract can induce adipogenesis without additional stem cells or growth factors. In this study, we innovatively investigated whether exosome-like vesicles derived from adipose tissue (ELV-AT) could direct stem cell differentiation and trigger adipose tissue regeneration. In vitro, ELV-AT can induce adipogenesis of adipose-derived stem cells and promote proliferation, migration, and angiogenic potential of the aorta endothelial cells. In vivo, ELV-AT were transplanted to a chamber on the back of nude mice and neoadipose tissues were formed. Our findings indicated that ELV-AT could be used as a cell-free therapeutic approach for adipose tissue regeneration.",
        "keywords": [
            "adipose tissue",
            "exosome-like vesicles",
            "regeneration"
        ],
        "authors": [
            {
                "name": "Minjia Dai",
                "org": "3 Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University , Chengdu, China ."
            },
            {
                "name": "Mei Yu",
                "org": "2 National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University , Chengdu, China ."
            },
            {
                "name": "Yan Zhang",
                "org": "3 Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University , Chengdu, China ."
            },
            {
                "name": "Weidong Tian",
                "org": "3 Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University , Chengdu, China ."
            }
        ],
        "venue": "Tissue engineering. Part A",
        "year": 2017
    },
    "r17gYZmj": {
        "id": "r17gYZmj",
        "title": "Comparison of Intra-arterial and Subcutaneous Testicular Hyaluronidase Injection Treatments and the Vascular Complications of Hyaluronic Acid Filler.",
        "abstract": "A complete enzymatic degradation of HA filler to hyaluronidase needs a certain time, and subcutaneous hyaluronidase treatment may be the better option.",
        "keywords": "",
        "authors": [
            {
                "name": "Muyao Wang",
                "org": "*State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R.China; \u2020Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, P.R.China; \u2021National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China."
            },
            {
                "name": "Wei Li",
                "org": ""
            },
            {
                "name": "Yan Zhang",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Hang Wang",
                "org": ""
            }
        ],
        "venue": "Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]",
        "year": 2017
    },
    "FNP5fDbo": {
        "id": "FNP5fDbo",
        "title": "Therapeutic applications of conditioned medium from adipose tissue",
        "abstract": "For the past number of decades, adipose tissue has attracted significant interest due to its complicated composition and versatile functions. Adipose tissue is no longer considered to be just an energy-storing fat pad, but is also a key ring player in interaction networks between various organs and tissues. A wide range of factors released by adipose tissue are responsible for regulation of adipose tissue and other distant target tissues and cells, such as kidneys, skeletal muscle, the cardiovascular system and the immune system, in an auto-/paracrine manner. A mixture of bioactive molecules makes up the conditioned medium of adipose tissue. The beneficial role played by these bioactive molecules in angiogenesis, wound healing, tissue regeneration and immunomodulation has been demonstrated by various studies. Study of this conditioned medium helps deepen our understanding of underlying mechanisms and broadens the potential for therapeutic applications. In this review, we have aimed to improve fundamental understanding of conditioned medium from adipose tissue and to summarize recent efforts to study its therapeutic applications.",
        "keywords": "",
        "authors": [
            {
                "name": "Minjia Dai",
                "org": "State Key Laboratory of Oral Disease West China School of Stomatology Sichuan University Chengdu 610041 China"
            },
            {
                "name": "Yan Zhang",
                "org": "State Key Laboratory of Oral Disease West China School of Stomatology Sichuan University Chengdu 610041 China"
            },
            {
                "name": "Mei Yu",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Disease West China School of Stomatology Sichuan University Chengdu 610041 China"
            }
        ],
        "venue": "Cell Proliferation",
        "year": 2016
    },
    "yCyJrvhX": {
        "id": "yCyJrvhX",
        "title": "miR-450a-5p within rat adipose tissue exosome-like vesicles promotes adipogenic differentiation by targeting WISP2",
        "abstract": "Adipose tissue is an active endocrine organ that could secrete a wide number of factors to regulate adipogenesis via paracrine signals. In addition to soluble proteins in adipose tissue, microRNAs (miRNAs) enriched in extracellular vesicles (EVs), such as exosomes or microvesicles, could modulate intercellular communications. In this study, we demonstrated that exosome-like vesicles derived from adipose tissue (Exo-AT) were internalized by adipose tissue-derived stem cells (ADSCs), then induced adipogenesis. High-throughput sequencing showed that 45 miRNAs were enriched in Exo-AT and 31.11% of them were associated with adipogenesis compared with ADSCs derived exosome-like vesicles (Exo-ADSC). miR-450a-5p, one of the most abundant miRNAs in Exo-AT, was a proadipogenic miRNA. Further study demonstrated that miR-450a-5p promoted adipogenesis through repressing expression of WISP2 by targeting its 3\u2018untranslated region. Additionally, Exo-AT could also downregulate the expression of WISP2 while miR-450a-5p inhibitors reversed this effect. Moreover, inhibition of miR-450a-5p impaired exosome-like vesicles mediated adipogenesis. In conclusion, Exo-AT mediated adipogenic differentiation through a mechanism involving transfer of miR-450a-5p.",
        "keywords": "",
        "authors": [
            {
                "name": "Yan Zhang",
                "org": "State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu 610041, China"
            },
            {
                "name": "Mei Yu",
                "org": "State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu 610041, China"
            },
            {
                "name": "Minjia Dai",
                "org": "State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu 610041, China"
            },
            {
                "name": "Chang Chen",
                "org": "State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu 610041, China"
            },
            {
                "name": "Qi Tang",
                "org": "State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu 610041, China"
            },
            {
                "name": "Wei Jing",
                "org": "State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu 610041, China"
            },
            {
                "name": "Hang Wang",
                "org": "State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu 610041, China"
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Disease, West China School of Stomatology, Sichuan University, Chengdu 610041, China"
            }
        ],
        "venue": "Journal of Cell Science",
        "year": 2017
    },
    "o3IKdUHm": {
        "id": "o3IKdUHm",
        "title": "Recent developments and clinical potential on decellularized adipose tissue: Decellularized Adipose Tissue",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jia Dong",
                "org": ""
            },
            {
                "name": "Mei Yu",
                "org": ""
            },
            {
                "name": "Yan Zhang",
                "org": ""
            },
            {
                "name": "Yin Yin",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Journal of Biomedical Materials Research Part A",
        "year": 2018
    },
    "Bi515Dpl": {
        "id": "Bi515Dpl",
        "title": "[Research progress in adipose tissue promoted wound healing].",
        "abstract": "Adipose tissue has generated great interest in recent years because of unique advantages such as abundant and accessible source, thriven potential to enhance the regeneration and repair of damaged tissue. However, there is still a need to explore the mechanism that adipose tissue regulates cellular function and tissue regeneration in order to facilitate clinical application of adipose tissue in wound healing.",
        "keywords": [
            "Adipose tissue",
            "extracellular matrix",
            "paracrine signaling",
            "wound repair"
        ],
        "authors": [
            {
                "name": "Yue Wu",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu Sichuan, 610041, P.R.China;Department of Oral & Maxillofacial Surgery, Xiangya Stomatological Hospital & School of Stomatology, Central South University, Changsha Hunan, 410006, P.R.China."
            },
            {
                "name": "Kun Li",
                "org": "Department of Oral & Maxillofacial Surgery, Xiangya Stomatological Hospital & School of Stomatology, Central South University, Changsha Hunan, 410006, P.R.China."
            },
            {
                "name": "Yan Zhang",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu Sichuan, 610041, P.R.China."
            },
            {
                "name": "Jia Dong",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu Sichuan, 610041, P.R.China."
            },
            {
                "name": "Mei Yu",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu Sichuan, 610041, P.R.China.yumei925@hotmail.com."
            },
            {
                "name": "Weidong Tian",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu Sichuan, 610041, P.R.China.drtwd@sina.com."
            }
        ],
        "venue": "Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery",
        "year": 2019
    },
    "ZtIje4Hk": {
        "id": "ZtIje4Hk",
        "title": "Effects on the expression of NF-kappaBp65 of osteoblast-like cell under stretch load with different daily loading times]",
        "abstract": "The purpose of this study was to investigate the effect on the expression of NF-kappaBp65 of osteoblast-like cell under stretch load with the same amplitude but different daily loading times. The osteoblast-like cells MG-63 were passage cultured and stretched by the four-point-bend loading device; based on the daily loading times, the osteoblast-like cells were randomly divided into four groups. The first was the control, the others were stretched with mechanical tension with the same amplitude of 2,000 mu strain and at the same frequency of 0.5 Hz., but the daily loading times were 1 time/d, 2 times/d, 4 times/d differently for each group, the periods of mechanical tension applied to the cells of the three groups were all 60 min/d and lasted for 2d total. After the cells being streteched, the expression levels of NF-kappaBp65 of the osteoblast-like cells of the three groups and control group were investigated by using the techniques of immunohistochemistry, and were compared with each other. The results showed that the positive expression ratios of the four groups were different significantly; the positive expression ratio of the control was lower than those of the other three groups; the positive expression ratio of the 4 times/d group was higher than those of the other two stretched groups; the positive expression ratio of the 2 times/d group was higher than that of the 1 time/d group. The results suggested that when the osteoblast-like cell was under the stretch load with different daily loading times but the same amplitude, the expression ratio of NF-kappaBp65 in the cell increased with the rising of the stimulating times. It means that the mechanical strain with high daily loading times could promote the transcriptional level of osteoblast-like cell more effectively.",
        "keywords": [
            "Stretch Daily loading times Osteoblast-like cell NF-\u03baBp65"
        ],
        "authors": [
            {
                "name": "Jie Long",
                "org": "West China College of Stomatology, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Weidong Tian",
                "org": "West China College of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Yubo Fan",
                "org": "Key Laboratory of Biomechanic Engineering,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Fan Feng",
                "org": "West China College of Stomatology,Sichuan University,Chengdu ,China"
            },
            {
                "name": "Shengwei Li",
                "org": "West China College of Stomatology,Sichuan University,Chengdu ,China"
            }
        ],
        "venue": "Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi",
        "year": 2008
    },
    "nimbZ6Z8": {
        "id": "nimbZ6Z8",
        "title": "Experimental studies on the poly-hydroxybutyrate membrane modified by gamma-radiation and mixed with calcium sulfate]",
        "abstract": "The objective of this study was to learn the property of poly-hydroxybutyrate membrane (PHBm) modified by gamma-radiation and mixture of calcium sulfate, and to explore the possibility of using modified PHBm for guided tissue regeneration (GTR). The PHB was treated by 5 KGy gamma-radiation and mixed with 1/10 calcium sulfate. The modified PHB membrane was prepared by solvent-casting techniques. The mechanical properties and molecular weight of the modified PHBm were tested. Degradability of the modified PHBm was analyzed in vitro in a buffer solution of KH2PO4-Na2HPO4. Biodegradability and biocompatibility of the modified PHBm were inspected 1, 2, 3 and 6 months after the embedding of the modified PHBm into dogs. The morphology was analyzed by scanning electron microscopy (SEM) and molecular weight was tested to evaluate the biodegradability of PHBm. Biocompatibility of the modified PHBm was observed through tissue response by light microscopy. The extension strength and the extension strain at fracture of the modified PHBm were 23.8 MPa and 1.0% respectively. The morphologic observation of the modified PHBm at different terms showed that the modified PHBm was biodegraded gradually in vitro and in vivo. The capsule surrounding the modified PHBm was mainly composed of fibrocytes and few lymphocytes. The longer the time elapsed, the thinner the capsule enveloping the modified PHBm grew. The modified PHBm possesses satisfactory mechanical properties and biocompatibility, and it is biodegradable in vitro and in vivo. The modified PHB membrane could be applied as GTR membrane.",
        "keywords": [],
        "authors": [
            {
                "name": "Chongyun Bao",
                "org": "West China College of Stomatology, Sichuan University, Biomaterial Research Center, Chengdu."
            },
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Ping Li",
                "org": ""
            },
            {
                "name": "Shengwei Li",
                "org": ""
            },
            {
                "name": "Xingdong Zhang",
                "org": ""
            }
        ],
        "venue": "Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi",
        "year": 2003
    },
    "w37LdHVn": {
        "id": "w37LdHVn",
        "title": "The effect of fluid shear stress on the NO synthesis of rat osteoblast-like cells]",
        "abstract": "This study sought to elucidate the function of NO during the signal transduction wherein fluid shear stress regulates the proliferation and differentiation of osteoblast cells. The isolated rat osteoblast-like cells were exposed to fluid shear stress 12 dyn/cm2 for 5, 10, 15, 30, 60 and 120 min respectively with the use of a flow chamber. The NO release was examined. After the exposure to fluid shear stress, the NO synthesis of rat primary osteoblast-like cells increased significantly (P<0.05) when compared with the control. After 60 minutes of exposure, the release of NO began to increase significantly (P<0.05), but no significant increase as such was seen in the control (P>0.05). NO synthesis may be one of the signal transduction pathways which transduce the fluid shear stress into osteoblast cells. In early stage, it may be induced by cNOS and in late stage by iNOS.",
        "keywords": [],
        "authors": [
            {
                "name": "Ju Qiao",
                "org": "West China College of Stomatology, Sichuan University, Chengdu 610041, China. doubean1@sina.com"
            },
            {
                "name": "Weihui Chen",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Shengwei Li",
                "org": ""
            },
            {
                "name": "Songjiao Luo",
                "org": ""
            }
        ],
        "venue": "Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi",
        "year": 2004
    },
    "4ltKZLjZ": {
        "id": "4ltKZLjZ",
        "title": "Morphological Study on hIL-1Ra Gene Therapy in a Rabbit Model of Temporomandibular Joints Osteoarthritis.",
        "abstract": "Objective:The purpose of this study was to examine the morphological change of TMJ after hIL-1Ra gene transfection through the direct delivery in the TMJ Osteoarthritis cavity.Methods: Twenty rabbits were divided into four experimental groups.Group 1 was received no treatment.Group 2 was received three consecutive intra-articular injections at 24-hour intervals of 0.9% saline containing a cationic lipid,and a DNA plasmid.Group 3 and 4 were received three consecutive injections of saline containing 100 and 200\u03bcg of hIL-1Ra plasmid and lipid.All rabbits were sacrificed after 4 weeks.The severity of macroscopic and microscopic change on cartilage and synovium were graded separately.Results: A significant reduction in the width of osteophytes and the size of macroscopic lesions were observed.A significant reduction was also noted in the severity of histology cartilage lesions in the group 3 and 4(P<0.01).Group 1 and 2 were not found change.Conclusion: This study demonstrated that direct in vivo transfer of the hIL-1Ra gene into osteoarthritis TMJ cells by using intra-articular injections of a plasmid vector and lipids can significantly reduce the progression of experimental osteoarthritis.This method may therefore represent a promising future treatment for TMJOA.",
        "keywords": [
            "Temporomandibular joints osteoarthritis hIL-1Ra Gene therapy"
        ],
        "authors": [
            {
                "name": "WANG Dong",
                "org": ",et al.Dongguan People's hospital,Dongguan "
            },
            {
                "name": "TIAN Wei-dong",
                "org": ",et al.Dongguan People's hospital,Dongguan "
            },
            {
                "name": "LI Sheng-wei",
                "org": ",et al.Dongguan People's hospital,Dongguan "
            }
        ],
        "venue": "Journal of Oral Science Research",
        "year": 2008
    },
    "5F7mqho9": {
        "id": "5F7mqho9",
        "title": "Animal model of temporomandibular joints osteoarthritis",
        "abstract": "Objective To establish an animal model for both the study of temporomandibular joints osteoarthritis(TMJOA)and the evaluation of gene therapeutic methods.Methods 37 New Zealand rabbits were divided into the experimental group,the negative control group and the healthy control group.The experimental group was injected with 1% type \u2161 collagenase 0.2 ml in the bilateral TMJ.All rabbits were killed at 4,8,12,16,20 and 24 weeks.The joints were removed and examined macroscopically and histologically.Results TMJ of experimental group of four weeks had the more obvious osteoarticular lesions,the 12-week group reached the peak lesions,and the 20,24-week group showed up a partial restoration phenomenon.Conclusion General and histopathological changes in rabbit temporomandibular joint were consistent with human TMJOA pathological changes.It had good similarity and comparability.So we successfully established a TMJOA animal model and prepared for gene therapy.",
        "keywords": [
            "rabbits",
            "temporomandibular joints osteoarthritis",
            "animal model"
        ],
        "authors": [
            {
                "name": "WANG Dong",
                "org": "Department of Oral and Maxillofacial Surgery,Dongguan People's Hospital,Dongguan ,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "Department of Oral and Maxillofacial Surgery,Dongguan People's Hospital,Dongguan ,China"
            },
            {
                "name": "LI Sheng-wei",
                "org": "Department of Oral and Maxillofacial Surgery,Dongguan People's Hospital,Dongguan ,China"
            },
            {
                "name": "LIU Xiao-hong",
                "org": "Department of Oral and Maxillofacial Surgery,Dongguan People's Hospital,Dongguan ,China"
            },
            {
                "name": "WANG Xiu-min",
                "org": "Department of Oral and Maxillofacial Surgery,Dongguan People's Hospital,Dongguan ,China"
            }
        ],
        "venue": "Stomatology",
        "year": 2008
    },
    "6B5q48M5": {
        "id": "6B5q48M5",
        "title": "The ultrastructure of temporomandibular joints in rabbit model of osteoarthritis",
        "abstract": "Objective:To observe ultrastructure change in rabbit model of TMJOA.Methods:35 Newzerland rabbits were divided into the experimental group and the healthy control group.the experimental group was injected 1% type \u2161 collagenase 0.2ml in the bilateral TMJ.All rabbits were killed at 4,8,12,16,20,24 weeks after injection.The joints were removed and examined through scanning electron microscope.Results:TMJ of experimental group 4 weeks after injection showed obvious osteoarticular lesions,which reached the peak lesions after 12-weeks,20,24-week group showed up a partial restoration phenomenon.Conclusion:Ultrastructure changes in Rabbit temporomandibular joint resemble human TMJOA pathological changes.It had good similarity and comparability.So we constructed successfully a TMJOA animal model.",
        "keywords": [
            "ultrastructure",
            "temporomandibular joints osteoarthritis",
            "animal model"
        ],
        "authors": [
            {
                "name": "WANG Dong",
                "org": "Dongguan people's hospital,Guangdong ,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "Dongguan people's hospital,Guangdong ,China"
            },
            {
                "name": "LI Sheng-wei",
                "org": "Dongguan people's hospital,Guangdong ,China"
            },
            {
                "name": "LIU Xiao-hong",
                "org": "Dongguan people's hospital,Guangdong ,China"
            }
        ],
        "venue": "Chinese Journal of Prosthodontics",
        "year": 2008
    },
    "YT29vhtb": {
        "id": "YT29vhtb",
        "title": "An Immunohistochemical Study on hIL-1Ra Gene Therapy in a Rabbit Model of Temporomandibular Joints Osteoarthritis",
        "abstract": "Objective To examine the gene expression of human Interleukin 1 Receptor Antagonist gene (hIL-1Ra) after gene transferation in temporomandibular joint (TMJ) osteoarthritis. Methods Eighteen Newzerland rabbits were divided into three groups and given the injection of 1% type \u2161 collagenase 0.2 mL in the right TMJ to establish the rabbit model of TMJ osteoarthritis. Then group 1 received three consecutive intra-articular injections at 24-hour intervals of 0.9% saline containing 200 \u03bcg of hIL-1Ra plasmid and lipid,while group 2 received three consecutive intra-articular injections of 0.9% saline containing a cationic lipid,and a DNA plasmid,at the same intervals. And group 3 received no treatment. All rabbits were sacrificed 4 weeks later. TMJ specimens were examined with immunohistochemical staining. Results In group 1 expression of hIL-1Ra protein were found in the synovium,cartilage and bone of infra-cartilagen but no expression were found in either group 2 or 3. Conclusion An extrogenous hIL-1Ra could be expressed in synovium,cartilage and bone of TMJ with gene transferation by intra-articular direct injection.",
        "keywords": [
            "hIL-1Ra",
            "Temporomandibular joints osteoarthritis",
            "Immunohistochemistry"
        ],
        "authors": [
            {
                "name": "WANG Dong",
                "org": ",et al. 1Dongguan People 's Hospital,Dongguan ,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": ",et al. 1Dongguan People 's Hospital,Dongguan ,China"
            },
            {
                "name": "LI Sheng-wei",
                "org": ",et al. 1Dongguan People 's Hospital,Dongguan ,China"
            }
        ],
        "venue": "Journal of Dental Prevention and Treatment",
        "year": 2008
    },
    "ZpNOB6lL": {
        "id": "ZpNOB6lL",
        "title": "A Study on Biological Security of Gene Transfection in the Temporomandibular Joint Cavity",
        "abstract": "Objective To study the possible effect of cationic lipid mediated human Interleukin 1 Receptor Antagonist gene transfection on the other organs through the direct delivery in the temporomandibular joint cavity. Methods Twenty Newzerland rabbits were divided into four groups. Group 1 and 2 received three consecutive injections at 24-hour intervals of 0.9% saline containing 100 and 200 \u03bcg of hIL-1Ra plasmid and lipid. Group 3 received three consecutive intra-articular injections at 24-hour intervals of 0.9% saline containing a cationic lipid, and a DNA plasmid. Group 4 received no treatment. All rabbits were sacrificed after 4 weeks. TMJ, liver, kidney, heart, spleen, lung, and pancreas were harvested. RT-PCR was applied to examine the expression of hIL-1Ra gene in these organs. Macroscopy and histologic evalution were also performed. Results The expression of hIL-1Ra mRNA in TMJ of experimental group 1 and 2 were detected by RT-PCR but not in any other organs. Pathologic disorder was found neither by macroscopic observation nor histological examination. Conclusion Intra-articular direct injection can achieve gene delivery limited to the joint cavity, possibly eliminating unnecessary systemic effects.",
        "keywords": [
            "Gene transfection",
            "Temporomandibular joint",
            "Biological security"
        ],
        "authors": [
            {
                "name": "WANG Dong",
                "org": ", et al. 1Dongguan People\u2019s Hospital, Dongguan , China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": ", et al. 1Dongguan People\u2019s Hospital, Dongguan , China"
            },
            {
                "name": "LI Sheng-wei",
                "org": ", et al. 1Dongguan People\u2019s Hospital, Dongguan , China"
            }
        ],
        "venue": "Journal of Dental Prevention and Treatment",
        "year": 2008
    },
    "CM4hR6yo": {
        "id": "CM4hR6yo",
        "title": "Molecule Mechanism of Cultivation of Tissue Engineering Bone",
        "abstract": "The bone loss is the common disease in oral facial maxillary. To repair the default is the puzzle in nowadays. But it\u2032s possible to repair the loss with the progress of the tissue engineering and gene. The method could conquer the problem of nowadays. To uncover the effect of the cytokines in and out of the cells on the bone develop- ment is very important in the further clinical research.",
        "keywords": [
            "cytokine",
            "osteogenesis",
            "bone formation",
            "bone tissue engineering"
        ],
        "authors": [
            {
                "name": "RAO Yan-gang",
                "org": "Dept. of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu , China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "Dept. of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu , China"
            }
        ],
        "venue": "International Journal of Stomatology",
        "year": 2007
    },
    "rkDSE6si": {
        "id": "rkDSE6si",
        "title": "Digital Diagnosis and Treatment Program for Maxillofacial Fractures: A Retrospective Analysis of 626 Cases.",
        "abstract": "The purpose of this study was to evaluate the accuracy of the digital diagnosis and treatment program for maxillofacial fractures.The data of 626 patients with maxillofacial fractures were analyzed retrospectively from January 2010 to August 2016. These patients were divided into 2 groups. In the experimental group, preoperative planning was conducted and transferred to patients with guiding templates and navigation according to the digital diagnosis and treatment program for maxillofacial fractures. In the control group, postsurgical planning was performed instead of preoperative planning. To assess the accuracy of the digital diagnosis and treatment program for maxillofacial fractures, preoperative planning and postoperative computed tomographic models were superimposed and imported to dedicated software (Geomagic Studio 13.0, Geomagic, Inc, Research Triangle Park, NC) to calculate the difference between the 2 models in the 2 groups.Results of the experimental set showed that the mean error between the preoperative planning model and the postoperative model ranged from 0.65 to 0.97 mm (average, 0.89 mm). For the control group, the mean error was 0.78 to 1.45 mm (average, 1.01 mm). Thus, the mean error of the experimental group was statistically lower than that of the control group (P < .0001). Postoperative analysis of the subjective evaluation of occlusion recovery showed that 92.13% of patients achieved good occlusion recovery in the experimental group compared with only 84.91% in the control group. The digital diagnosis and treatment program for maxillofacial fractures was more accurate.Aided by the digital diagnosis and treatment program, the accuracy for maxillofacial fractures was notably improved. To facilitate the application and promotion of digital technology, further modification of the complete digital diagnosis and treatment pathway for maxillofacial fractures is highly desired.",
        "keywords": "",
        "authors": [
            {
                "name": "Wei Zeng",
                "org": "Resident, Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Xiaotian Lian",
                "org": "Resident, Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Gang Chen",
                "org": "Resident, Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Rui Ju",
                "org": "Resident, Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weidong Tian",
                "org": "Professor, Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Wei Tang",
                "org": "Professor, Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China."
            }
        ],
        "venue": "Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons",
        "year": 2017
    },
    "9fuxIAUI": {
        "id": "9fuxIAUI",
        "title": "Symmetric convolutional neural network for mandible segmentation.",
        "abstract": "Abstract   Mandible segmentation is an essential step in craniomaxillofacial surgery planning, which aims to segment mandible from multi-slice computed tomography (MSCT) images. One main disadvantage of most existing mandible segmentation methods is that they require numerous expert knowledge for semi-automatic segmentation. However, the high-quality expert knowledge is hard to achieve in practice due to the scarcity of experienced doctors and experts. To solve this problem, we propose an end-to-end trainable deep learning based method, which performs segmentation in an automatic, accurate and efficient manner. Different from the popular convolutional neural network (CNN), our proposed symmetric convolutional neural network (SCNN) enforces convolution and deconvolution computation to be symmetric as to achieve a good segmentation performance. Furthermore, benefiting from the manner of end-to-end, SCNN could automatically perform mandible segmentation from raw image data. Such advantages remarkably reduce the human effort and achieve competitive performance. To verify the effectiveness of our method, we build a multi-slice computer tomography mandible dataset which includes 93 cases. The experimental results show that the proposed SCNN is superior to several popular baselines in terms of the dice similarity coefficient (DSC).",
        "keywords": "",
        "authors": [
            {
                "name": "Ming Yan",
                "org": "Machine Intelligence Lab, College of Computer Science, Sichuan University, Chengdu 610065, PR China"
            },
            {
                "name": "Jixiang Guo",
                "org": "Machine Intelligence Lab, College of Computer Science, Sichuan University, Chengdu 610065, PR China"
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China"
            },
            {
                "name": "Zhang Yi",
                "org": "Machine Intelligence Lab, College of Computer Science, Sichuan University, Chengdu 610065, PR China"
            }
        ],
        "venue": "Knowl.-Based Syst.",
        "year": 2018
    },
    "wbGzZxmU": {
        "id": "wbGzZxmU",
        "title": "Comparative Proteomic Analyses of Human Adipose Extracellular Matrices Decellularized Using Alternative Procedures.",
        "abstract": "Decellularized human adipose tissue has potential clinical utility as a processed biological scaffold for soft tissue cosmesis, grafting and reconstruction. Adipose tissue decellularization has been accomplished using enzymatic-, detergent-, and/or solvent-based methods. To examine the hypothesis that distinct decellularization processes may yield scaffolds with differing compositions, the current study employed mass spectrometry to compare the proteomes of human adipose-derived matrices generated through three independent methods combining enzymatic-, detergent-, and/or solvent-based steps. In addition to protein content, bioscaffolds were evaluated for DNA depletion, ECM composition, and physical structure using optical density, histochemical staining, and scanning electron microscopy (SEM). Mass spectrometry (MS) based proteomic analyses identified 25 proteins (having at least two peptide sequences detected) in the scaffolds generated with an enzymatic approach, 143 with the detergent approach, and 102 with the solvent approach, as compared to 155 detected in unprocessed native human fat. Immunohistochemical detection confirmed the presence of the structural proteins actin, collagen type VI, fibrillin, laminin, and vimentin. Subsequent in vivo analysis of the predominantly enzymatic- and detergent-based decellularized scaffolds following subcutaneous implantation in GFP transgenic mice demonstrated that the matrices generated with both approaches supported the ingrowth of host-derived adipocyte progenitors and vasculature in a time dependent manner. Together, these results determine that decellularization methods influence the protein composition of adipose tissue-derived bioscaffolds. This article is protected by copyright. All rights reserved.",
        "keywords": [
            "Adipose Tissue",
            "Bioscaffold",
            "Decellularization",
            "Extracellular Matrix",
            "Mass Spectrometry Proteomics",
            "Regenerative Medicine"
        ],
        "authors": [
            {
                "name": "Caasy Thomas-Porch",
                "org": "Center for Stem Cell Research & Regenerative Medicine, Tulane University School of Medicine, New Orleans, LA."
            },
            {
                "name": "Jie Li",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Fabiana Zanata",
                "org": "Federal University of Sao Paulo, Sao Paulo, SP, Brazil."
            },
            {
                "name": "Elizabeth C Martin",
                "org": "Department of Agricultural and Biological Engineering, Louisiana State University, Baton Rouge, LA."
            },
            {
                "name": "Nicholas Pashos",
                "org": "Center for Stem Cell Research & Regenerative Medicine, Tulane University School of Medicine, New Orleans, LA."
            },
            {
                "name": "Kaylynn Genemaras",
                "org": "Center for Stem Cell Research & Regenerative Medicine, Tulane University School of Medicine, New Orleans, LA."
            },
            {
                "name": "J Nicholas Poche",
                "org": "Department of Agricultural and Biological Engineering, Louisiana State University, Baton Rouge, LA."
            },
            {
                "name": "Nicholas P Totaro",
                "org": "Department of Agricultural and Biological Engineering, Louisiana State University, Baton Rouge, LA."
            },
            {
                "name": "Melyssa R Bratton",
                "org": "Department of Chemistry, Xavier University of Louisiana, New Orleans, LA."
            },
            {
                "name": "Dina Gaupp",
                "org": "Center for Stem Cell Research & Regenerative Medicine, Tulane University School of Medicine, New Orleans, LA."
            },
            {
                "name": "Trivia Frazier",
                "org": "Department of Structural and Cell Biology, Tulane University School of Medicine, New Orleans, LA."
            },
            {
                "name": "Xiying Wu",
                "org": "LaCell LLC, New Orleans, LA."
            },
            {
                "name": "Lydia Masako Ferreira",
                "org": "Federal University of Sao Paulo, Sao Paulo, SP, Brazil."
            },
            {
                "name": "Weidong Tian",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Guangdi Wang",
                "org": "Department of Chemistry, Xavier University of Louisiana, New Orleans, LA."
            },
            {
                "name": "Bruce A Bunnell",
                "org": "Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA."
            },
            {
                "name": "Lauren Flynn",
                "org": "Department of Anatomy and Cell Biology, Western University, London, ON, Canada."
            },
            {
                "name": "Daniel Hayes",
                "org": "Department of Biomedical Engineering, Pennsylvania State University, State College, PA."
            },
            {
                "name": "Jeffrey M Gimble",
                "org": "Department of Surgery, Tulane University School of Medicine, New Orleans, LA."
            }
        ],
        "venue": "Journal of biomedical materials research. Part A",
        "year": 2018
    },
    "rUcAeJKq": {
        "id": "rUcAeJKq",
        "title": "Comparative proteomic analyses of human adipose extracellular matrices decellularized using alternative procedures: COMPARATIVE PROTEOMIC ANALYSES OF HUMAN ADIPOSE ECM",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Caasy Thomas-Porch",
                "org": "Biomedical Science Program, Tulane University School of Medicine; New Orleans Louisiana"
            },
            {
                "name": "Jie Li",
                "org": "Center for Stem Cell Research & Regenerative Medicine; Tulane University School of Medicine; New Orleans Louisiana"
            },
            {
                "name": "Jie Li",
                "org": "Center for Stem Cell Research & Regenerative Medicine; Tulane University School of Medicine; New Orleans Louisiana"
            },
            {
                "name": "Fabiana Zanata",
                "org": "Center for Stem Cell Research & Regenerative Medicine; Tulane University School of Medicine; New Orleans Louisiana"
            },
            {
                "name": "Fabiana Zanata",
                "org": "Center for Stem Cell Research & Regenerative Medicine; Tulane University School of Medicine; New Orleans Louisiana"
            },
            {
                "name": "Elizabeth C. Martin",
                "org": "Department of Biological and Agricultural Engineering; Louisiana State University; Baton Rouge Louisiana"
            },
            {
                "name": "Nicholas C. Pashos",
                "org": "Center for Stem Cell Research & Regenerative Medicine; Tulane University School of Medicine; New Orleans Louisiana"
            },
            {
                "name": "Kaylynn Genemaras",
                "org": "Center for Stem Cell Research & Regenerative Medicine; Tulane University School of Medicine; New Orleans Louisiana"
            },
            {
                "name": "J. Nicholas Poche",
                "org": "Department of Biological and Agricultural Engineering; Louisiana State University; Baton Rouge Louisiana"
            },
            {
                "name": "Nicholas P. Totaro",
                "org": "Department of Biological and Agricultural Engineering; Louisiana State University; Baton Rouge Louisiana"
            },
            {
                "name": "Melyssa R. Bratton",
                "org": "Department of Chemistry; Xavier University of Louisiana; New Orleans Louisiana"
            },
            {
                "name": "Dina Gaupp",
                "org": "Center for Stem Cell Research & Regenerative Medicine; Tulane University School of Medicine; New Orleans Louisiana"
            },
            {
                "name": "Trivia Frazier",
                "org": "Center for Stem Cell Research & Regenerative Medicine; Tulane University School of Medicine; New Orleans Louisiana"
            },
            {
                "name": "Xiying Wu",
                "org": "LaCell LLC; New Orleans Louisiana"
            },
            {
                "name": "Lydia Masako Ferreira",
                "org": "Federal University of Sao Paulo; Sao Paulo SP Brazil"
            },
            {
                "name": "Weidong Tian",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology; Sichuan University; Chengdu China"
            },
            {
                "name": "Guangdi Wang",
                "org": "Department of Chemistry; Xavier University of Louisiana; New Orleans Louisiana"
            },
            {
                "name": "Bruce A. Bunnell",
                "org": "Center for Stem Cell Research & Regenerative Medicine; Tulane University School of Medicine; New Orleans Louisiana"
            },
            {
                "name": "Lauren E. Flynn",
                "org": "Department of Chemical and Biochemical Engineering; Western University; London Ontario Canada"
            },
            {
                "name": "Daniel J. Hayes",
                "org": "Department of Biomedical Engineering; Pennsylvania State University; State College Pennsylvania"
            },
            {
                "name": "Jeffrey M. Gimble",
                "org": "Center for Stem Cell Research & Regenerative Medicine; Tulane University School of Medicine; New Orleans Louisiana"
            }
        ],
        "venue": "Journal of Biomedical Materials Research Part A",
        "year": 2018
    },
    "C5ARHlFK": {
        "id": "C5ARHlFK",
        "title": "Concentrated Growth Factor Enhanced Fat Graft Survival: A Comparative Study.",
        "abstract": "In this preliminary study, CGF treatment improved the survival and quality of fat grafts.",
        "keywords": "",
        "authors": [
            {
                "name": "Yun Hu",
                "org": "Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, P.R.China."
            },
            {
                "name": "Yichen Jiang",
                "org": "Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, P.R.China."
            },
            {
                "name": "Muyao Wang",
                "org": "Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, P.R.China."
            },
            {
                "name": "Weidong Tian",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R.China."
            },
            {
                "name": "Hang Wang",
                "org": "Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu, P.R.China."
            }
        ],
        "venue": "Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]",
        "year": 2018
    },
    "KgcK8TV9": {
        "id": "KgcK8TV9",
        "title": "The establishment of a chemically defined serum-free culture system for human dental pulp stem cells.",
        "abstract": "Human DPSCs (hDPSCs) in E8 medium demonstrated greater\u00a0proliferation, pluripotency, migration ability\u00a0and less apoptosis. hDPSCs\u00a0could be successfully\u00a0induced to the adipogenic, osteogenic, neurogenic, and chondrogenic lineages\u00a0in E8 group. Real-time polymerase chain reaction indicated that the expression of PPAR-\u03b3, RUNX2, OCN and\u00a0MAP-2\u00a0was higher in E8 group.\u00a0 CONCLUSIONS: Compared with serum-containing medium, E8 medium exhitibed higher ability in maintaining the cell proliferation, pluripotency, migration, and stability. This new serum-free culture environment might be applicable for hDSC culture in the future.",
        "keywords": [
            "Dental pulp stem cells",
            "Dental stem cell bank",
            "Essential 8 Medium",
            "Serum-free culture"
        ],
        "authors": [
            {
                "name": "Jingyi Xiao",
                "org": "Department of Pediatric Dentistry, West China School of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Dawei Yang",
                "org": "Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China."
            },
            {
                "name": "Qiwen Li",
                "org": "State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & National Engineering, Chengdu, China."
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, No.14, 3rd Section, Renmin South Road, Chengdu, 610041, People's Republic of China. drtwd@sina.com."
            },
            {
                "name": "Weihua Guo",
                "org": "Department of Pediatric Dentistry, West China School of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China. guoweihua943019@163.com."
            }
        ],
        "venue": "Stem cell research & therapy",
        "year": 2018
    },
    "ZpXDj6Px": {
        "id": "ZpXDj6Px",
        "title": "The establishment of a chemically defined serum-free culture system for human dental pulp stem cells.",
        "abstract": "Human DPSCs (hDPSCs) in E8 medium demonstrated greater\u00a0proliferation, pluripotency, migration ability\u00a0and less apoptosis. hDPSCs\u00a0could be successfully\u00a0induced to the adipogenic, osteogenic, neurogenic, and chondrogenic lineages\u00a0in E8 group. Real-time polymerase chain reaction indicated that the expression of PPAR-\u03b3, RUNX2, OCN and\u00a0MAP-2\u00a0was higher in E8 group.\u00a0 CONCLUSIONS: Compared with serum-containing medium, E8 medium exhitibed higher ability in maintaining the cell proliferation, pluripotency, migration, and stability. This new serum-free culture environment might be applicable for hDSC culture in the future.",
        "keywords": [
            "Dental pulp stem cells",
            "Dental stem cell bank",
            "Essential 8 Medium",
            "Serum-free culture"
        ],
        "authors": [
            {
                "name": "Jingyi Xiao",
                "org": "Department of Pediatric Dentistry, West China School of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Dawei Yang",
                "org": "Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China."
            },
            {
                "name": "Qiwen Li",
                "org": "State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & National Engineering, Chengdu, China."
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, No.14, 3rd Section, Renmin South Road, Chengdu, 610041, People's Republic of China. drtwd@sina.com."
            },
            {
                "name": "Weihua Guo",
                "org": "Department of Pediatric Dentistry, West China School of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China. guoweihua943019@163.com."
            }
        ],
        "venue": "Stem cell research & therapy",
        "year": 2018
    },
    "5z0Ic0sV": {
        "id": "5z0Ic0sV",
        "title": "Parathyroid hormone-related peptide (1-34) promotes tooth eruption and inhibits osteogenesis of dental follicle cells during tooth development.",
        "abstract": "Dental follicle cells (DFCs) activate and recruit osteoclasts for tooth development and tooth eruption, whereas DFCs themselves differentiate into osteoblasts to form alveolar bone surrounding tooth roots through the interaction with Hertwig's epithelial root sheath (HERS). Also during tooth development, parathyroid hormone-related peptide (PTHrP) is expressed surrounding the tooth germ. Thus, we aimed to investigate the effect of PTHrP (1-34) on bone resorption and osteogenesis of DFCs in vitro and in vivo. In vitro studies demonstrated that DFCs cocultured with HERS cells expressed higher levels of\u00a0BSP and OPN than the DFCs control group, whereas cocultured DFCs treated with PTHrP (1-34) had lower expressions of ALP, RUNX2, BSP, and OPN than the cocultured DFCs control group. Moreover, we found PTHrP (1-34) inhibited osteogenesis of cocultured DFCs by inactivating the Wnt/\u03b2-catenin pathway. PTHrP (1-34) also increased the expression of RANKL/OPG ratio in DFCs. Consistently, in vivo study found that PTHrP (1-34) accelerated tooth eruption and inhibited alveolar bone formation. Therefore, these results suggest that PTHrP (1-34) accelerates tooth eruption and inhibits osteogenesis of DFCs by inactivating Wnt/\u03b2-catenin pathway.",
        "keywords": [
            "Hertwig's epithelial root sheath cell",
            "dental follicle cell",
            "osteogenesis",
            "parathyroid hormone-related peptide",
            "tooth eruption"
        ],
        "authors": [
            {
                "name": "Jiawei Zhang",
                "org": "Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Lijun Liao",
                "org": "Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Yuyu Li",
                "org": "Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Yang Xu",
                "org": "Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weihua Guo",
                "org": "Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            },
            {
                "name": "Shujuan Zou",
                "org": "Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China."
            }
        ],
        "venue": "Journal of cellular physiology",
        "year": 2018
    },
    "KL1pVg76": {
        "id": "KL1pVg76",
        "title": "Parathyroid hormone-related peptide (1-34) promotes tooth eruption and inhibits osteogenesis of dental follicle cells during tooth development: ZHANG et al.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jiawei Zhang",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University; Chengdu China"
            },
            {
                "name": "Lijun Liao",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University; Chengdu China"
            },
            {
                "name": "Yuyu Li",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University; Chengdu China"
            },
            {
                "name": "Yang Xu",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University; Chengdu China"
            },
            {
                "name": "Weihua Guo",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University; Chengdu China"
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University; Chengdu China"
            },
            {
                "name": "Shujuan Zou",
                "org": "State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University; Chengdu China"
            }
        ],
        "venue": "Journal of Cellular Physiology",
        "year": 2018
    },
    "bDfwhfUO": {
        "id": "bDfwhfUO",
        "title": "Hyperglycemia Induces Osteoclastogenesis and Bone Destruction Through the Activation of Ca 2+ /Calmodulin-Dependent Protein Kinase II.",
        "abstract": "Hyperglycemia induces osteoclastogenesis and bone resorption through complicated, undefined mechanisms. Ca/calmodulin-dependent protein kinase II (CaMKII) promotes osteoclastogenesis, and could be activated by hyperglycemia. Here, we investigated whether CaMKII is involved in hyperglycemia-induced osteoclastogenesis and subsequent bone resorption. Osteoclast formation, bone resorption, CaMKII expression and phosphorylation were measured under high glucose in vitro and in streptozotocin-induced hyperglycemia rats with or without CaMKII inhibitor KN93. The results showed that 25\u00a0mmol/L high glucose in vitro promoted cathepsin K and tartrate-resistant acid phosphatase expression (p\u2009<\u20090.05) and osteoclast formation (p\u2009<\u20090.01) associated with enhancing \u03b2 isoform expression (p\u2009<\u20090.05) and CaMKII phosphorylation (p\u2009<\u20090.001). Hyperglycemia promoted the formation of osteoclasts and resorption of trabecular and alveolar bone, and inhibited sizes of femur and mandible associated with enhanced CaMKII phosphorylation (p\u2009<\u20090.001) in rats. All these changes could be alleviated by KN93. These findings imply that CaMKII participates not only in hyperglycemia-induced osteoclastogenesis and subsequent bone resorption, but also in the hyperglycemia-induced developmental inhibition of bone.",
        "keywords": [
            "Bone resorption",
            "Ca2+/calmodulin-dependent protein kinase II",
            "Hyperglycemia",
            "Osteoclast",
            "Type 1 diabetes mellitus"
        ],
        "authors": [
            {
                "name": "Yanxin Shen",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Shujuan Guo",
                "org": "Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Guoqing Chen",
                "org": "National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Yi Ding",
                "org": "Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China."
            },
            {
                "name": "Yafei Wu",
                "org": "Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China. yfw1110@163.com."
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China. drtwd@sina.com."
            }
        ],
        "venue": "Calcified tissue international",
        "year": 2018
    },
    "BxQxE3vZ": {
        "id": "BxQxE3vZ",
        "title": "Hyperglycemia Induces Osteoclastogenesis and Bone Destruction Through the Activation of Ca<Superscript>2+</Superscript>/Calmodulin-Dependent Protein Kinase II",
        "abstract": "Hyperglycemia induces osteoclastogenesis and bone resorption through complicated, undefined mechanisms. Ca2+/calmodulin-dependent protein kinase II (CaMKII) promotes osteoclastogenesis, and could be activated by hyperglycemia. Here, we investigated whether CaMKII is involved in hyperglycemia-induced osteoclastogenesis and subsequent bone resorption. Osteoclast formation, bone resorption, CaMKII expression and phosphorylation were measured under high glucose in vitro and in streptozotocin-induced hyperglycemia rats with or without CaMKII inhibitor KN93. The results showed that 25\u00a0mmol/L high glucose in vitro promoted cathepsin K and tartrate-resistant acid phosphatase expression (p\u2009<\u20090.05) and osteoclast formation (p\u2009<\u20090.01) associated with enhancing \u03b2 isoform expression (p\u2009<\u20090.05) and CaMKII phosphorylation (p\u2009<\u20090.001). Hyperglycemia promoted the formation of osteoclasts and resorption of trabecular and alveolar bone, and inhibited sizes of femur and mandible associated with enhanced CaMKII phosphorylation (p\u2009<\u20090.001) in rats. All these changes could be alleviated by KN93. These findings imply that CaMKII participates not only in hyperglycemia-induced osteoclastogenesis and subsequent bone resorption, but also in the hyperglycemia-induced developmental inhibition of bone.",
        "keywords": [
            "Hyperglycemia",
            " Type 1 diabetes mellitus",
            " Osteoclast",
            " Ca2+/calmodulin-dependent protein kinase II",
            " Bone resorption"
        ],
        "authors": [
            {
                "name": "Yanxin\u00a0Shen",
                "org": "State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology,Sichuan University,Chengdu,People\u2019s Republic of China"
            },
            {
                "name": "Shujuan\u00a0Guo",
                "org": "State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology,Sichuan University,Chengdu,People\u2019s Republic of China"
            },
            {
                "name": "Guoqing\u00a0Chen",
                "org": "State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology,Sichuan University,Chengdu,People\u2019s Republic of China"
            },
            {
                "name": "Yi\u00a0Ding",
                "org": "State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology,Sichuan University,Chengdu,People\u2019s Republic of China"
            },
            {
                "name": "Yafei\u00a0Wu",
                "org": "State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology,Sichuan University,Chengdu,People\u2019s Republic of China"
            },
            {
                "name": "Weidong\u00a0Tian",
                "org": "State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology,Sichuan University,Chengdu,People\u2019s Republic of China"
            }
        ],
        "venue": "Calcified Tissue International",
        "year": 2018
    },
    "SemNjOQb": {
        "id": "SemNjOQb",
        "title": "An outcome analysis of two methods of intra-capsular injection of sodium hyaluronate for temporomandibular disorders]",
        "abstract": "To analyze the treatment outcome of the two methods of intra-capsular injection of temporomandibular joints, the upper capsule alone and both the upper and lower capsules, for different subtypes of temporomandibular disorders.A retrospective cohort study was designed, based on the outpatients and the data which were obtained from West China Stomatological Hospital, Sichuan University. SPSS10.0 software was used to analyze the data, which were collected before the operation and one week after the operation.294 patients were followed up. The group of double capsules injection gained better prospect, not only on the mouth-opening but also the pain-cured, especially in two subgroups such as the anterior dislocation of disc without reduction and the osteoarthritis of TMJ.It seems that the double capsules injection of sodium hyaluronate for TMD can gain better outcome than the upper capsule injection, but a clinical randomized controlled test and a long-term follow-up study of the two methods are needed to verify this finding.",
        "keywords": [],
        "authors": [
            {
                "name": "Xiao-dong Li",
                "org": "Dept. of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, China."
            },
            {
                "name": "Zong-dao Shi",
                "org": ""
            },
            {
                "name": "Wei-dong Tian",
                "org": ""
            }
        ],
        "venue": "Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology",
        "year": 2004
    },
    "EETAsUSD": {
        "id": "EETAsUSD",
        "title": "Effects of human interleukin-1 receptor antagonist gene transfection on condylar chondrocytes of temporomandibular joint",
        "abstract": "Objective:To investigate the effects of human interleukin-1 receptor antagonist (hIL-1ra) gene transfection on condylar chondrocytes of temporomandibular joint (TMJ). Methods:Cultured condylar chondrocytes of TMJ were transfected by hIL-1ra gene via cationic liposome. The proliferation of the transfected cells was examined by MTT assay. The nitrate reductase method was used to measure the nitric oxide (NO) synthesis in the supernatant of cell culture, normal TMJ chondrocytes without gene transfection were served as the controls. Results:The population doubling time(h) of transfected cells and the controls was 118.62\u00b127.85 and 135.26\u00b113.34 respectively. When the cells were exposed to IL-1\u03b2 the proliferation of transfected cells was increased more than that of the controls. NO concentration in transfected cells was lower than that in the controls with the presence or absence of IL-1\u03b2(P< 0.01 ). Conclusion:hIL-1ra gene can antagonized the role of IL-1\u03b2.",
        "keywords": [
            "Gene transfection",
            "Chondrocyte",
            "Interleukin-1 receptor antagonist",
            "Condylar"
        ],
        "authors": [
            {
                "name": "Li Yisong",
                "org": ",et al. Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital, Kunming Medical College, Kunming , China"
            },
            {
                "name": "Tian Weidong",
                "org": ",et al. Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital, Kunming Medical College, Kunming , China"
            },
            {
                "name": "Chen Xizhe",
                "org": ",et al. Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital, Kunming Medical College, Kunming , China"
            }
        ],
        "venue": "Journal of Practical Stomatology",
        "year": 2006
    },
    "4JmyQyob": {
        "id": "4JmyQyob",
        "title": "Retrospective analysis of 3,958 patients with facial injuries]",
        "abstract": "To determine the causes and incidence of facial injuries by an epidemiologic retrospective study.A total of 3 958 patients with facial injuries treated at Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University from 1955 to 2001 were investigated. Data regarding age, gender, cause of injury, pattern of fracture and associated systemic injuries were reviewed.The male to female ratio of the patients with facial injury was 4.27:1 and 33.4% of patients were aged between 21 and 30 years. The most common cause of injury was traffic accident (30.6%), followed by falls (21.4%) and collision (15.8%). A total of 794 patients (20.1%) showed only soft tissue injuries. 1 100 patients (27.8%) had multiple fractures in facial bones and 2,064 patients (52.1%) had single fracture. The mandibular fracture was most frequently seen, followed by the maxilla and the zygoma. The most common site of mandible fracture was the body (31.2%), followed by the symphysis (22.7%), the condylar (20.5%) and the angle (13.7%). Accompanied injuries to brain and skull happened in 916 patients (23.1%).Bone fractures were more common in hospitalized patients with facial injuries. The numbers and sites of fracture were related to the causes of injuries and anatomic structure of the bone. The brain and skull injuries, the most often and seriously accompanied injuries, would not be neglected.",
        "keywords": [
            "epidemiology",
            "wounds and injuries",
            "fractures"
        ],
        "authors": [
            {
                "name": "Yi-song Li",
                "org": ". Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Kunming Medical College, Kunming  , China"
            },
            {
                "name": "Wei-dong Tian",
                "org": ". Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Kunming Medical College, Kunming  , China"
            },
            {
                "name": "Sheng-wei Li",
                "org": ". Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Kunming Medical College, Kunming  , China"
            },
            {
                "name": "Liu Liu",
                "org": ". Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Kunming Medical College, Kunming  , China"
            }
        ],
        "venue": "Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology",
        "year": 2006
    },
    "zMRWaZkw": {
        "id": "zMRWaZkw",
        "title": "An inductive signalling network regulates mammalian tooth morphogenesis with implications for tooth regeneration.",
        "abstract": "Sequential and reciprocal epithelial-mesenchymal interactions, essential throughout such aspects of tooth morphogenesis as patterning, size and number of teeth, involves a well-ordered series of inductive and permissive signals that exert global control over cell proliferation, differentiation and organogenesis. In particular, growth factors, transcription factors and their corresponding receptors, as well as other soluble morphogens, make up a regulatory network at the molecular level that synergistically or antagonistically controls intra-/inter-cellular signal transduction during odontogenesis. This review summarizes recent advances in the study of crucial signalling pathways, for example of BMPs, Wnt, Notch, Shh and FGF, with emphasis on the potential integrated signalling network responsible for tooth formation. Our work probes into the complexity of these inductive signalling pathways to promote the understanding of tooth regeneration. Additionally, our study provides further insights into therapeutic strategies for various dental abnormalities in patterning and number, such as tooth agenesis and supernumerary teeth.",
        "keywords": [],
        "authors": [
            {
                "name": "Z Li",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "M Yu",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "W Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Cell proliferation",
        "year": 2013
    },
    "QIRYz2zo": {
        "id": "QIRYz2zo",
        "title": "In vitro odontoblast-like cell differentiation of cranial neural crest cells induced by fibroblast growth factor 8 and dentin non-collagen proteins.",
        "abstract": "During tooth development, cranial neural crest (CNC) cells represent a population of pluripotent stem cells that give rise to various dental tissues. This study aimed to investigate whether CNC cells could differentiate into odontoblast-like cells by in vitro induction. CNC cells were isolated from explants of cranial neural tubes and cultured in serum-free Dulbecco's modified Eagle's medium (DMEM)/F12 medium which contained fibroblast growth factor 8 (FGF8) and dentin non-collagen proteins (DNCP). The initiation of controlled differentiation was determined using histological assays, and the expression of specific gene phenotypes was detected using immunocytochemical staining and reverse transcription--polymerase chain reaction (RT--PCR). The first branchial arch phenotype of the CNC cells demonstrated negative Hoxa2 expression and positive vimentin expression in the presence of 100 ng/ml FGF8. Following DNCP induction, the CNC cells became bipolar, demonstrated high alkaline phosphatase (ALP) activity, and formed mineralized nodules. In addition, the expression of DSPP, DMP1, and collagen type I confirmed the odontoblast phenotype. The results indicate that the tissue-specific cellular differentiation (odontoblast-like cells) of early-stage embryonic-derived cells (such as CNC cells) can be induced by adult extracellular matrix proteins (such as DNCP). CNC cells may be used as a valuable cell model for research on dental tissue differentiation and regeneration.",
        "keywords": [
            "dentin non-collagen protein",
            "odontoblast-like cell",
            "fibroblast growth factor 8",
            "cranial neural crest cell",
            "differentiation",
            "dmem",
            "extracellular matrix proteins",
            "reverse transcription polymerase chain reaction",
            "neural crest",
            "cellular differentiation",
            "neural crest cell",
            "alkaline phosphatase",
            "stem cell",
            "polymerase chain reaction",
            "cell differentiation"
        ],
        "authors": [
            {
                "name": "Hong-Bing Jiang",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Wei-Dong Tian",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lai-Kui Liu",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Yan Xu",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            }
        ],
        "venue": "Cell biology international",
        "year": 2008
    },
    "BDGlcYvX": {
        "id": "BDGlcYvX",
        "title": "The role of antimiR-26a-5p/biphasic calcium phosphate in repairing rat femoral defects.",
        "abstract": "Although miRNAs have been implicated in the osteogenic differentiation of stem cells, their role in bone repair and reconstruction in tissue\u2011engineered bone grafts remains unclear. We previously reported that microRNA (miR)\u201126a\u20115p inhibited the osteogenic differentiation of adipose\u2011derived mesenchymal stem cells (ADSCs), and that antimiR\u201126a\u20115p exerted the opposite effect. In the present study, the role of miR\u201126a\u20115p\u2011 and antimiR\u201126a\u20115p\u2011modified ADSCs combined with biphasic calcium phosphate (BCP) scaffolds was evaluated in a rat femur defect model. The aim of the present study was to improve the understanding of the role of miR\u201126a\u20115p in bone regeneration in vivo, as well as to provide a new method to optimize the osteogenic ability of BCPs. ADSCs were infected with Lv\u2011miR\u201126a\u20115p, Lv\u2011miR\u2011NC, Lv\u2011antimiR\u201126a\u20115p or Lv\u2011antimiR\u2011NC respectively, and then combined with BCP scaffolds to repair rat femoral defects. Using X\u2011rays, micro\u2011computed tomography and histology at 2, 4, and 8 weeks postoperatively, the quantity and rate of bone regeneration were analyzed, revealing that they were the highest in animals treated with antimiR\u201126a\u20115p and the lowest in the miR\u201126a\u20115p treatment group. The expression levels of osteocalcin, collagen I, Runt\u2011related transcription factor 2, Wnt family member 5A and calmodulin\u2011dependent protein kinase II proteins were positively correlated with the bone formation rate. Taken together, the present results demonstrated that miR\u201126a\u20115p inhibited bone formation while antimiR\u201126a\u20115p accelerated bone formation via the Wnt/Ca2+ signaling pathway. Therefore, antimiR\u201126a\u20115p\u2011modified ADSCs combined with BCP scaffolds may be used to construct an effective tissue\u2011engineering bone graft for bone repair and reconstruction.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaoyan Yuan",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Lu Han",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Hai Lin",
                "org": "National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan 610064, P.R. China."
            },
            {
                "name": "Zeyou Guo",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Yanling Huang",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Shasha Li",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Ting Long",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Wei Tang",
                "org": "Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Weidong Tian",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            },
            {
                "name": "Jie Long",
                "org": "The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, Sichuan 610041, P.R. China."
            }
        ],
        "venue": "International journal of molecular medicine",
        "year": 2019
    },
    "A797r9uk": {
        "id": "A797r9uk",
        "title": "Quantitative Association Rules Mining Based on Mutual Information Entropy of Attributes",
        "abstract": "On the research of quantitative association rules mining in database which contains quantitative attributes,the combination of the quantitative attributes and the intervals associated leads to an unmanageably highly sized itemsets and association rule sets which constitute a hamper toward the efficiency of the mining algorithm.The mutual information entropy of the attributes is studied here,and algorithm BMIQAR which can find the frequent itemsets and association rules from the attributes sets with strong information relationship is designed.The experiments show that due to the prune on the attributes,the research space decreases sharply,so the mining efficiency is improved greatly,and the acquired association rules are high confidence ones.",
        "keywords": [
            "mutual information entropy",
            "data mining",
            "quantitative association rules"
        ],
        "authors": [
            {
                "name": "LIU Le-le",
                "org": "School of Computer and Information,Hefei University of Technology,Hefei "
            },
            {
                "name": "TIAN Wei-dong",
                "org": "School of Computer and Information,Hefei University of Technology,Hefei "
            }
        ],
        "venue": "Computer Engineering",
        "year": 2009
    },
    "a2L1VRiR": {
        "id": "a2L1VRiR",
        "title": "A Parallel Algorithm for Mining Frequent Itemsets Based on SMP",
        "abstract": "Mining association rules from large databases is an important problem in data mining.Symmetric Multi-Processor systems based on memory-sharing have already been the widely used parallel computing system nowadays.In this paper,on the basis of the research of the apriori algorithm,which is the classic algorithm for mining association rules,a parallel algorithm which can be running on SMP machine was proposed.Through the performance analysis and experiment,it can be easily concluded that this parallel algorithm works well and has speedup performance.",
        "keywords": [
            "parallel algorithm",
            "data mining",
            "association rules",
            "symmetric multiprocessor"
        ],
        "authors": [
            {
                "name": "TIAN Wei-dong",
                "org": "School of Computer and Information,Hefei University of Technology,Hefei ,China"
            },
            {
                "name": "WANG Dan-yang",
                "org": "School of Computer and Information,Hefei University of Technology,Hefei ,China"
            },
            {
                "name": "HU Xue-gang",
                "org": "School of Computer and Information,Hefei University of Technology,Hefei ,China"
            }
        ],
        "venue": "Journal of Guangxi Normal University(Natural Science Edition)",
        "year": 2008
    },
    "q7HsI3HM": {
        "id": "q7HsI3HM",
        "title": "Mining Algorithm of Maximal Frequent Itemsets Suitable to Specific Database",
        "abstract": "Aiming at the low mining efficiency problem existing in the mining association rules of FP-growth algorithm on data limited with item counts and transaction length, an improved algorithm(All-subset tree) for mining maximal frequent patterns is proposed, a novel data structure, All-subset tree, which is similar to FP-tree is introduced to store all maximal frequent item sets. The algorithm is in no need of appointed minimum support before scanning the database, and need not rescan the database when assigned minimum support dynamically. Experimental results show that all-subset tree algorithm greatly improves the mining efficiency compared with FP-growth algorithm when mining specific database.",
        "keywords": [
            "data mining",
            "association rule",
            "Frequent Pattern tree(FP-tree)",
            "maximal frequent itemsets"
        ],
        "authors": [
            {
                "name": "WANG Hua",
                "org": " Computer Center, Anhui Medical University, Hefei "
            },
            {
                "name": "HU Xue-gang",
                "org": " School of Computer &Information, Hefei University of Technology, Hefei "
            },
            {
                "name": "TIAN Wei-dong",
                "org": " School of Computer &Information, Hefei University of Technology, Hefei "
            }
        ],
        "venue": "Computer Engineering",
        "year": 2008
    },
    "QfCw1ATV": {
        "id": "QfCw1ATV",
        "title": "Application-level Business Continuity Scheme Based on Metro/Global Mirror Technology",
        "abstract": "An application-level business continuity scheme is proposed in this paper for solving the deficiency of the current business continuity system in a bank enterprise.Based on Metro/Global Mirror(MGM) technology supported by storage device,the scheme which employs two-site-three-center model in a city guarantees the high availability of AS/400 mainframe on local site and rapid recovery ability on remote site.Test results show that this scheme can ensure the security and continuity of data,the decrease in runtime performance of the AS/400 mainframe is no more than 5% while it works normally,RTO and RPO indicator can achieve application level.",
        "keywords": [
            "Metro/Global Mirror(MGM) technology",
            "application-level",
            "cluster",
            "disaster backup and recovery",
            "high availability",
            "business continuity"
        ],
        "authors": [
            {
                "name": "TIAN Wei-dong",
                "org": "School of Computer & Information,Hefei University of Technology,Hefei ,China"
            },
            {
                "name": "CAO Yu-rong",
                "org": "School of Computer & Information,Hefei University of Technology,Hefei ,China;Anhui Rural Credit Union,Hefei ,China"
            },
            {
                "name": "ZHOU Qiang",
                "org": "Anhui Provincial Tobacco Corporation,Hefei ,China"
            }
        ],
        "venue": "Computer Engineering",
        "year": 2011
    },
    "cr1KVgtK": {
        "id": "cr1KVgtK",
        "title": "Discernibility Matrix Based on Constraint Function and Algorithm of Core-computation",
        "abstract": "When performing some inconsistent decision tables,the obtained core-attributes are false by the core-computed method of Hu.Therefore,a definition of discernibility and a method of core-computation based on the constraint function are proposed,which correct the error of core solution from its imperfect for the definition of discernibility metrix in Hu\u2019s method.Besides,the correctness of method is proved in theory and a quick core-computed algorithm is given.Extensive experimental study shows the time and space capability outperforms the core-computed method of Ye Dongyi.",
        "keywords": [
            "core attribute",
            "discernibility matrix",
            "rough set"
        ],
        "authors": [
            {
                "name": "ZHOU Chuang-de",
                "org": "School of Computer and Information,Hefei University of Technology,Hefei "
            },
            {
                "name": "TIAN Wei-dong",
                "org": "School of Computer and Information,Hefei University of Technology,Hefei "
            }
        ],
        "venue": "Computer Engineering",
        "year": 2008
    },
    "Xfy2PEOC": {
        "id": "Xfy2PEOC",
        "title": "A Simplified-discernibility-matrix-based Algorithm for Attribute Reduction in Rough Set",
        "abstract": "Traditional algorithm has relatively poor efficiency in both time and space when obtaining attribute reduction. Based on SDM,a new algorithm of attribute reduction called ARSDM is proposed in this paper. ARSDM takes the idea of classifying the universe of decision table according to the value of decision attribute firstly,then reducing and sorting elements of SDM while constructing them. The experimental study shows that the algorithm of ARSDM outperforms the traditional algorithms largely on both time and space.",
        "keywords": [
            "Attribute reduction",
            "Data mining",
            "Discernability matrix",
            "Rough set",
            "Inconsistent decision table"
        ],
        "authors": [
            {
                "name": "TIAN Wei-Dong",
                "org": "School of Computer and Information,Hefei University of Technology,Hefei "
            },
            {
                "name": "ZHOU Chuang-De",
                "org": "School of Computer and Information,Hefei University of Technology,Hefei "
            },
            {
                "name": "HU Xue-Gang",
                "org": "School of Computer and Information,Hefei University of Technology,Hefei "
            },
            {
                "name": "ZHOU Hong-Juan",
                "org": "School of Computer and Information,Hefei University of Technology,Hefei "
            },
            {
                "name": "LI Pei-Pei",
                "org": "School of Computer and Information,Hefei University of Technology,Hefei "
            }
        ],
        "venue": "Computer Science",
        "year": 2008
    },
    "YUVYDOVT": {
        "id": "YUVYDOVT",
        "title": "Research on emergency material dispatch model orienting multi-level depots",
        "abstract": "According to the characters of the material scheduling in emergency relief activities at present in China,based on the multi-level depots priority model,related to the disaster place,this paper established a multi-depot,multi-disaster place and multi-objective optimization emergency scheduling model,which solved the problem of the earliest emergency start time and the least disaster relief participated place,and designed a solution to the model.Utilized an example to verify the validity and rationality of the model.The model now is successfully applied in the design of the emergency relief supplies scheduling system and the material scheduling simulation scheme for the earthquake disaster in Yushu.",
        "keywords": [
            "multi-objective optimization",
            "emergency relief",
            "material dispatch",
            "multi-level depots"
        ],
        "authors": [
            {
                "name": "TIAN Wei-dong",
                "org": "School of Computer & Information,Hefei University of Technology,Hefei ,China"
            },
            {
                "name": "ZHAO Li",
                "org": "School of Computer & Information,Hefei University of Technology,Hefei ,China"
            }
        ],
        "venue": "Application Research of Computers",
        "year": 2011
    },
    "hscPuRiw": {
        "id": "hscPuRiw",
        "title": "Fuzzy inference system based on B-spline membership function",
        "abstract": "It is hard to determine the membership function and inference rules in fuzzy reasoning.By studying the fuzzy reasoning process and the characteristics of B-spline function,the reasoning method on the application of B-spline function fitting to fuzzy membership function was improved.Through the calculation and selection of the extreme points of error and the extreme point of curvature,the B-spline function data points were obtained.After obtaining the control points by inversing data points,the curve fitting of the membership function was increased and the B-spline membership function fitting problem was solved on the curve of the B-spline by increasing the control points.B-spline inference rule was established and B-spline inference system was constructed,and then the final result of the system was calculated as a B-spline hypersurface.Finally,the experimental results validate the effectiveness and feasibility of this method.",
        "keywords": [
            "membership function",
            "B-spline function",
            "B-spline surface",
            "fitting"
        ],
        "authors": [
            {
                "name": "LI Jing",
                "org": "School of Computer and Information,Hefei University of Technology,Hefei Anhui ,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "School of Computer and Information,Hefei University of Technology,Hefei Anhui ,China"
            }
        ],
        "venue": "Journal of Computer Applications",
        "year": 2011
    },
    "TXIFkFMW": {
        "id": "TXIFkFMW",
        "title": "Recognition of focus based on CRF and TBL",
        "abstract": "Focusing on inaccurate recognition of focus in Chinese question classification,this paper presented a method based on condition random fields model(CRF) and TBL.First,it used the CRF model in tagging focuses in the questions initially.Then,it rectified the initial tagging results according to the contextual information with TBL algorithm.Besides,during the process of training ordered rules,it used an improvement on TBL algorithm based on the features of focus in order to reduce the training time.The experimental results show that the method can improve the accuracy rate of focus tagging to a great extend,and up to 88%.",
        "keywords": [
            "ordered rules",
            "question classification",
            "focus",
            "contextual information",
            "transformation-based error-driven learning(TBL)",
            "condition random fields model(CRF)"
        ],
        "authors": [
            {
                "name": "TIAN Wei-dong",
                "org": "School of Computer & Information,Hefei University of Technology,Hefei ,China"
            },
            {
                "name": "LI Ya-juan",
                "org": "School of Computer & Information,Hefei University of Technology,Hefei ,China"
            }
        ],
        "venue": "Application Research of Computers",
        "year": 2013
    },
    "jWnsUkGA": {
        "id": "jWnsUkGA",
        "title": "Question classification based on self-learning rules and modified Bayes",
        "abstract": "According to the Chinese question,this paper presented a question classification method which combined selflearning rules,consisting of question word-category rules and question word + head word-category rules established in advance by the self-learning method,and modified Bayesian model to improve Chinese question classification. At last,combined modified Bayesian model to improve question classification. The method takes advantage of the contribution of  key words to Chinese question classification. Experimental results show that this classification method is a considerable improvement,and accuracy rate a chieves 84% .",
        "keywords": [
            "question classification",
            "rule",
            "modified Bayesian model",
            "head word",
            "question word",
            "question answering system"
        ],
        "authors": [
            {
                "name": "TIAN Wei-dong",
                "org": " School of Computer & Information,Hefei University of Technology,Hefei ,China"
            },
            {
                "name": "GAO Yan-ying",
                "org": " School of Computer & Information,Hefei University of Technology,Hefei ,China"
            },
            {
                "name": "ZU Yong-liang",
                "org": " School of Computer & Information,Hefei University of Technology,Hefei ,China"
            }
        ],
        "venue": "Application Research of Computers",
        "year": 2010
    },
    "cboPgqPW": {
        "id": "cboPgqPW",
        "title": "Effective parallel algorithm for mining frequent itemsets",
        "abstract": "There were problems in traditional parallel algorithms for mining frequent itemsets,such as load imbalance,frequent synchronization,large scale communication and so on.Aiming at solving these problems,this paper proposed a parallel algorithm with multi-transmitting redistributed data(MRPD).In MRPD,data was redistributed into some groups at step l,and all the groups were multi-transmitted according to the request of computer nodes.Each node would compute frequent itemsets asynchronously after having received one full group.Finally,resulted the integrated frequent itemsets.Theoretical analysis and experimental results suggest that MRPD is effective.",
        "keywords": [
            "parallel algorithm",
            "frequent itemsets",
            "data mining"
        ],
        "authors": [
            {
                "name": "WANG Dan-yang",
                "org": "School of Computer & Information,Hefei University of Technology,Hefei ,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "School of Computer & Information,Hefei University of Technology,Hefei ,China"
            },
            {
                "name": "HU Xue-gang",
                "org": "School of Computer & Information,Hefei University of Technology,Hefei ,China"
            }
        ],
        "venue": "Application Research of Computers",
        "year": 2008
    },
    "HS2P9nJc": {
        "id": "HS2P9nJc",
        "title": "Design and Analysis of Producer-consumer Problem Based on Semaphore Mechanism",
        "abstract": "Producer-consumer problem is a classic example of processes synchronization and mutual exclusion in teaching of operating system.Deep understanding that is of great significance for right understanding of the process management.In this paper,a multi-threaded based simulation programming of this problem is presented.Two different semaphore mechanisms: producer and consumer processes with shared mutex or two different mutexes,are compared on the impact of operational efficiency by actual test.In addition to a visual image to students,it can also guide students on the problem in-depth reflection and inspire their awareness of innovation.",
        "keywords": [
            "visualization",
            "process synchronization",
            "programming",
            "producer-consumer problem",
            "operating system"
        ],
        "authors": [
            {
                "name": "LIU Xiao-ping",
                "org": "School of Computer Science and Information Engineering,Hefei University of Technology,Hefei ,China"
            },
            {
                "name": "SHI Hui",
                "org": "School of Computer Science and Information Engineering,Hefei University of Technology,Hefei ,China"
            },
            {
                "name": "LING Shi",
                "org": "School of Computer Science and Information Engineering,Hefei University of Technology,Hefei ,China"
            },
            {
                "name": "DU Lin",
                "org": "School of Computer Science and Information Engineering,Hefei University of Technology,Hefei ,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "School of Computer Science and Information Engineering,Hefei University of Technology,Hefei ,China"
            }
        ],
        "venue": "Journal of Hefei University of Technology(Social Sciences)",
        "year": 2008
    },
    "DOZzmM9O": {
        "id": "DOZzmM9O",
        "title": "Fixed precision fuzzy reasoning method based on B-spline basis function",
        "abstract": "The reasoning process uses layered structure embodies the thinking of the experts to analyze and solve the problems.Membership function decides all the features of fuzzy set, its form is various.The application of the reasoning methods that only concern the specific membership functions has limitations.This paper approximates the membership functions based on the properties of Bspline function.The system using this method only has to solve the operation and design of the basis function.It also has good expansibility and practicability. Experiments verify that the approximation error can be controlled by adjusting feature points using the curvature of the membership function. So, the precision of the whole reasoning method can also be controlled.",
        "keywords": [
            "Membership function",
            "B-spline basis function",
            "Precision",
            "Feature points",
            "Approximation error",
            "Fuzzy reasoning"
        ],
        "authors": [
            {
                "name": "XIONG De-jing",
                "org": ""
            },
            {
                "name": "HU Xue-gang",
                "org": ""
            },
            {
                "name": "TIAN Wei-dong",
                "org": ""
            }
        ],
        "venue": "Microcomputer Information",
        "year": 2010
    },
    "BF38QLVJ": {
        "id": "BF38QLVJ",
        "title": "Effective Mining Algorithm for Parallel Sequential Patterns",
        "abstract": "Under the parallel computer environment with shared memory, imbalance of processors' workload and lack of effective pruning methods are two key problems in mining sequential patterns.To solve these problems, dynamic tasks distribution method for achieving balance of workload among processors and the parallel local pruning technology used to improve the mining efficiency by avoiding abundant duplicated projected databases are proposed.A parallel algorithm for mining sequential patterns using these two methods based on Symmetric MultiProcessor(SMP) computer system, Parallel Fast Sequential Pattern mining algorithm(PFSPAN) is proposed in this paper.Both theoretical analyses and practical experiments show that PFSPAN can mine sequential patterns effectively.",
        "keywords": [
            "sequential patterns",
            "data mining",
            "parallel disposal",
            "local pruning",
            "task distribution"
        ],
        "authors": [
            {
                "name": "TIAN Wei-dong",
                "org": "School of Computer & Information, Hefei University of Technology, Hefei "
            },
            {
                "name": "JIANG Hai-hui",
                "org": "School of Computer & Information, Hefei University of Technology, Hefei "
            }
        ],
        "venue": "Computer Engineering",
        "year": 2009
    },
    "6aDIui8T": {
        "id": "6aDIui8T",
        "title": "Online pattern matching with wildcards",
        "abstract": "In this paper we present a new algorithm to handle the pattern matching problem where the pattern can contain flexible wildcards. Given a sequence S and a pattern P consisting of subpatterns separated by flexible wildcards, the problem is to find P's all occurrences with exact match positions under the one-off condition and length constraints. We propose an algorithm, PMW that locates each subpattern of P in S as soon as it appears in S in O(m+n+f(GM+\u03b1)) time with O(m+A) space overhead. Compared to the previous peers theoretical analysis and experimental results show that PMW is more competitive. It has an advantage on both the time and space complexities. It also has better stability with the increasing of the maximum gap constraints or the number of subpatterns.",
        "keywords": [
            "computational complexity",
            "pattern matching"
        ],
        "authors": [
            {
                "name": "Jipeng Qiang",
                "org": "School of Computer Science and Information Engineering, Hefei University of Technology, China, 230009"
            },
            {
                "name": "Weidong Tian",
                "org": "School of Computer Science and Information Engineering, Hefei University of Technology, China, 230009"
            },
            {
                "name": "Dan Guo",
                "org": "School of Computer Science and Information Engineering, Hefei University of Technology, China, 230009"
            },
            {
                "name": "Xindong Wu",
                "org": "Department of Computer Science, University of Vermont, USA, 05405"
            }
        ],
        "venue": "GrC",
        "year": 2012
    },
    "ttmEGBJJ": {
        "id": "ttmEGBJJ",
        "title": "Multiple pattern matching with wildcards and one-off conditon",
        "abstract": "Multiple pattern matching with wildcards is an important research task in many domains, such as information retrieval, bioinformatics and text indexing. In this paper, we address the following problem: given multiple pattern \u03a9P and a sequence S, we aim to handle multiple pattern \u03a9P simultaneously online and locate all their occurrences in S under the one-off condition. The user can specify the constraints on the number of wildcards between two consecutive characters of \u03a9P. We design two efficient algorithms BWW and FWW based on nondeterministic finite state automaton and bit-parallelism technology. Experimental results show that they are more efficient than other peers, especially dozens of times faster on average than SAIL. FWW is twice faster than BPBM in DNA sequences, when the length of multiple pattern increases. 1553-9105/Copyright \u00a9 2013 Binary Information Press.",
        "keywords": [
            "Bit-parallelism",
            "Multiple pattern matching",
            "Nondeterministic finite state automaton",
            "Wildcards"
        ],
        "authors": [
            {
                "name": "Jipeng Qiang",
                "org": "Hefei University of Technology(Hefei University of Technology),Hefei,China"
            },
            {
                "name": "Dan Guo",
                "org": "Hefei University of Technology(Hefei University of Technology),Hefei,China"
            },
            {
                "name": "Yuan Fang",
                "org": "Xi'an University of Engineering Science and Technology(Xi'an University of Science and Technology),Xi An,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Hefei University of Technology(Hefei University of Technology),Hefei,China"
            },
            {
                "name": "Xuegang Hu",
                "org": "Hefei University of Technology(Hefei University of Technology),Hefei,China"
            }
        ],
        "venue": "Journal of Computational Information Systems",
        "year": 2013
    },
    "KiMMJupN": {
        "id": "KiMMJupN",
        "title": "An ensemble learning algorithm based on generalized attribute value partitioning",
        "abstract": "The method of disturbing training data randomly to train individual classifiers has been widely applied in some ensemble learning methods such as Bagging and Boosting to achieve strong generalization ability, however, it seems something blind. In this paper, a new ensemble learning algorithm named GAVPEL is proposed. By using the hierarchy nature of the data set, GAVPEL leverages the generalized attribute value partitioning method to form an ensemble tree, called a generalized classifier hierarchy tree. While classifying, GAVPEL selects part of the individual classifiers based on attribute value and ensembles them with majority voting. Experiment results show that GAVPEL can efficiently improve generalization performance when compared with some popular ensemble learning algorithms. \u00a9 2011 SPIE.",
        "keywords": [
            "ensemble learning",
            "generalization ability",
            "knowledge granularity",
            "selective ensemble",
            "algorithms"
        ],
        "authors": [
            {
                "name": "Weidong Tian",
                "org": "Hefei University of Technology(Hefei University of Technology),Hefei,China"
            },
            {
                "name": "Fang Wu",
                "org": "Hefei University of Technology(Hefei University of Technology),Hefei,China"
            },
            {
                "name": "Jipeng Qiang",
                "org": "Hefei University of Technology(Hefei University of Technology),Hefei,China"
            },
            {
                "name": "Hongjuan Zhou",
                "org": "Hefei University of Technology(Hefei University of Technology),Hefei,China"
            }
        ],
        "venue": "Proceedings of SPIE - The International Society for Optical Engineering",
        "year": 2011
    },
    "HCJk25Rc": {
        "id": "HCJk25Rc",
        "title": "Uncertain information fusion method based on proof theory and fuzzy distance",
        "abstract": "For the problem of expert uncertainty view is hard to fuse in decision support system,this paper proposes a compromise based on evidence theory and fuzzy distance ideas to decision fusion.Apply fuzzy distance method to obtain the expert weight and property index relative weight.The uncertain problem of the subjective views of expert decision-making is studied.And then use DS evidence theory recognition framework to calculate the probability distribution function,sort and select all programs,to obtain the final decision fusion view.Examples show that the method is reasonable and efficient for integration of decision-making uncertain information.",
        "keywords": [
            "evidence theory",
            "criterion weight",
            "expert weight",
            "uncertain information",
            "fuzzy distance"
        ],
        "authors": [
            {
                "name": "TIAN Weidong",
                "org": " School of Computer and Information,Hefei University of Technology,Hefei ,China"
            },
            {
                "name": "ZHANG Jianliang",
                "org": " School of Computer and Information,Hefei University of Technology,Hefei ,China"
            }
        ],
        "venue": "Computer Engineering and Applications",
        "year": 2011
    },
    "K43ZpRJq": {
        "id": "K43ZpRJq",
        "title": "Preliminary Study on Heuristic-inquiry Teaching Method for Operating System Course",
        "abstract": "Operating System course have some characteristics of multi-concept,widely-content and complicated algorithm which makes it difficult for students to understand and master the course.To resolve the problem, heuristic-inquiry teaching method is introduced into the Operating System course.The application of this method in practical teaching is illustrated by taking producer-consumer problem as an example and the result proved to be fine.",
        "keywords": [
            "Operating System",
            "producer-consumer problem",
            "heuristic teaching",
            "inquiry teaching"
        ],
        "authors": [
            {
                "name": "LIU Xiaoping",
                "org": "School of Computer&Information,Hefei University of Technology,Hefei ,China"
            },
            {
                "name": "CHEN Xin",
                "org": "School of Computer&Information,Hefei University of Technology,Hefei ,China"
            },
            {
                "name": "LI Lin",
                "org": "School of Computer&Information,Hefei University of Technology,Hefei ,China"
            },
            {
                "name": "LU Qiang",
                "org": "School of Computer&Information,Hefei University of Technology,Hefei ,China"
            },
            {
                "name": "TIAN Weidong",
                "org": "School of Computer&Information,Hefei University of Technology,Hefei ,China"
            }
        ],
        "venue": "Computer Education",
        "year": 2011
    },
    "oNDi9V4a": {
        "id": "oNDi9V4a",
        "title": "Answer extraction scheme based on answer pattern and semantic feature fusion",
        "abstract": "Answer extraction is the key technology of the automatic question answering system.According to analysis of question-answer pairs,there is not only semantic similarity,but also syntactic relevance between them.This paper proposes a new method based on bicharacteristic fusion of answer pattern and semantic features.Using the weight to describe the contribution of each feature,a better MRR can be made for each question category.Compared to other methods,this method can fully describe the answer\u2019s features,and then more accurate result can be achieved.",
        "keywords": [
            "sentence similarity",
            "answer extraction",
            "question answering",
            "feature fusion",
            "pattern matching"
        ],
        "authors": [
            {
                "name": "TIAN Weidong",
                "org": " School of Computer & Information,Hefei University of Technology,Hefei ,China"
            },
            {
                "name": "ZU Yongliang",
                "org": " School of Computer & Information,Hefei University of Technology,Hefei ,China"
            }
        ],
        "venue": "Computer Engineering and Applications",
        "year": 2011
    },
    "Q66HW0It": {
        "id": "Q66HW0It",
        "title": "Study of disaster relief goods dispatching model and its intelligent solution approach for state reserve system of rescue goods and materials",
        "abstract": "According to practical organization of disaster relief goods and materials dispatching activities in China, a novel relief goods and materials dispatching model for multi-depot and multi-disaster area is established. This model is based on the multi-level depot priority model and is formalized as a multi-objective optimization problem with the earliest emergency start time and the least number of participated depots. To approach this model, the particle swarm optimization algorithm is adopted. We also integrated this model into the disaster relief goods dispatching application successfully and applied for programming the simulated dispatching plan for Yushu earthquake disaster. The results prove the efficiency of the proposed model and its intelligent solution approach. \u00a9 2011 SPIE.",
        "keywords": [
            "disaster relief",
            "dispatching model",
            "multi-objective optimization",
            "particle swarm optimization",
            "computer programming"
        ],
        "authors": [
            {
                "name": "Weidong Tian",
                "org": "Hefei University of Technology(Hefei University of Technology),Hefei,China"
            },
            {
                "name": "Hongjuan Zhou",
                "org": "Hefei University of Technology(Hefei University of Technology),Hefei,China"
            },
            {
                "name": "Li Zhao",
                "org": "Hefei University of Technology(Hefei University of Technology),Hefei,China"
            },
            {
                "name": "Yang Lu",
                "org": "Hefei University of Technology(Hefei University of Technology),Hefei,China"
            }
        ],
        "venue": "Proceedings of SPIE - The International Society for Optical Engineering",
        "year": 2011
    },
    "Mh5O3EGJ": {
        "id": "Mh5O3EGJ",
        "title": "Estimating surface water area changes using time-series Landsat data in the Qingjiang River Basin, China",
        "abstract": "",
        "keywords": [
            "water"
        ],
        "authors": [
            {
                "name": "zhiqiang du",
                "org": "wuhan university"
            },
            {
                "name": "bin linghu",
                "org": "chinese academy of sciences"
            },
            {
                "name": "feng ling",
                "org": "chinese academy of sciences"
            },
            {
                "name": "wenbo li",
                "org": "chinese academy of sciences"
            },
            {
                "name": "weidong tian",
                "org": "hefei university of technology"
            },
            {
                "name": "hailei wang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "yuanmiao gui",
                "org": "chinese academy of sciences"
            },
            {
                "name": "bingyu sun",
                "org": "chinese academy of sciences"
            },
            {
                "name": "xiaoming zhang",
                "org": "chinese academy of sciences"
            }
        ],
        "venue": "Journal of Applied Remote Sensing",
        "year": 2012
    },
    "fus2l7JP": {
        "id": "fus2l7JP",
        "title": "On Universal Disaster Backup System based on CDP for Municipal Tobacco Branches",
        "abstract": "Continuous data protection which is booming in recent years is a kind of new disaster backup and recovery technologies.Based on the observations to the characteristics of the identical topology structure of branches of Anhui Tobacco Inc,a universal remote disaster backup and recovery system scheme based on CDP is designed.The scheme can not only be used to provide disaster backup for local base,but also can be used to extend disaster backup using remote base,and especially can copy data from production center to remote backup center just using lowcost 2M bps special line.And data modified at any time can be recovered from the CDP device during disaster recovery.Technical tests and scheme\u2019s practical application in Fuyang branch show that the scheme is feasible.",
        "keywords": [
            "disaster backup and recovery",
            "bi-base backup model",
            "continuous data protection",
            "business continuity"
        ],
        "authors": [
            {
                "name": "ZHOU Qiang",
                "org": "Anhui Provincial Tobacco Monopoly Bureau,Hefei,Anhui ,China"
            },
            {
                "name": "ZHAO Hai-feng",
                "org": "China United Network Telecommunications Corporation Anhui Branch,Hefei,Anhui ,China"
            },
            {
                "name": "JI Yun",
                "org": "Hefei University of Technology,Hefei,Anhui ,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "Hefei University of Technology,Hefei,Anhui ,China"
            }
        ],
        "venue": "Computer Security",
        "year": 2012
    },
    "DltR0pcw": {
        "id": "DltR0pcw",
        "title": "On Risk Assessment of Distributed Information System: A Sample of Anhui Tobacco Inc.",
        "abstract": "Identifying and assessing main risks of distributed information system is the first key step for constructing disaster backup and recovery system.In this paper,distributed information system of Anhui Tobacco Inc.is taken as an example to show how to analyze risks which it faces,including risks in environment,management,equipment,technology and etc.Then an assessment-making model based on Analytic Hierarchy Process is proposed.And,combined with expert scoring,severities of various risks which may menace distributed information system of Anhui Tobacco are calculated and sorted and primary risk sources are identified,which provide a good foundation for disaster backup and recovery system which will be constructed in the future.",
        "keywords": [
            "distributed information system",
            "analytic hierarchy process",
            "disaster backup and recovery",
            "risk assessment"
        ],
        "authors": [
            {
                "name": "ZHAO Hai-feng",
                "org": "China United Network Telecommunications Corporation Anhui Branch,Hefei,Anhui Prov.,China"
            },
            {
                "name": "Yu Yong-yong",
                "org": "Hefei University of Technology,Hefei,Anhui Prov.,China"
            },
            {
                "name": "ZHOU Qiang",
                "org": "Anhui Provincial Tobacco Monopoly Bureau,Hefei,Anhui Prov.,China"
            },
            {
                "name": "ZHOU Hong-juan",
                "org": "Hefei University of Technology,Hefei,Anhui Prov.,China"
            },
            {
                "name": "TIAN Wei-dong",
                "org": "Hefei University of Technology,Hefei,Anhui Prov.,China"
            }
        ],
        "venue": "Computer Security",
        "year": 2012
    },
    "ve4qX9MZ": {
        "id": "ve4qX9MZ",
        "title": "PORTFOLIO MANAGEMENT WITH CONSTRAINTS",
        "abstract": "The traditional portfolio selection problem concerns an agent whose objective is to maximize the expected utility of terminal wealth over some horizon. This basic prob- lem can be modified by adding constraints. In this paper we investigate the portfolio selection problem for an investor who desires to outperform some benchmark index with a certain confidence level. The benchmark is chosen to reflect some particular in- vestment objective and it can be either deterministic or stochastic. The optimal strategy for this class of problems can lead to nonconvex constraints raising issues of existence and uniqueness. We solve this optimal portfolio selection problem and investigate the procedure for both deterministic and stochastic benchmarks.",
        "keywords": [
            "nonconvex constraints",
            "portfolio selection",
            "beating benchmark",
            "expected utility",
            "confidence level",
            "portfolio management",
            "indexation"
        ],
        "authors": [
            {
                "name": "Phelim Boyle",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Mathematical Finance",
        "year": 2007
    },
    "COHfK4Ns": {
        "id": "COHfK4Ns",
        "title": "Optimal design of equity-linked products with a probabilistic constraint",
        "abstract": "",
        "keywords": [
            "expected utility",
            "optimal design",
            "indexation"
        ],
        "authors": [
            {
                "name": "Phelim Boyle",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Scandinavian Actuarial Journal",
        "year": 2009
    },
    "QoHYZ6nW": {
        "id": "QoHYZ6nW",
        "title": "The design of equity-indexed annuities",
        "abstract": "There is a rich variety of tailored investment products available to the retail investor in every developed economy. These contracts combine upside participation in bull markets with downside protection in bear markets. Examples include equity-linked contracts and other types of structured products. This paper analyzes these contracts from the investor\u2019s perspective rather than the issuer\u2019s using concepts and tools from financial economics. We analyze and critique their current design and examine their valuation from the investor\u2019s perspective. We propose a generalization of the conventional design that has some interesting features. The generalized contract specifications are obtained by assuming that the investor wishes to maximize end of period expected utility of wealth subject to certain constraints. The first constraint is a guaranteed minimum rate of return which is a common feature of conventional contracts. The second constraint is new. It provides the investor with the opportunity to outperform a benchmark portfolio with some probability. We present the explicit form of the optimal contract assuming both constraints apply and we illustrate the nature of the solution using specific examples. The paper focusses on equity-indexed annuities as a representative type of such contracts but our approach is applicable to other types of equity-linked contracts and structured products.",
        "keywords": [
            "equity-indexed annuities",
            "g13",
            "g12",
            "optimal design",
            "equity-linked contracts",
            "optimal portfolio selection",
            "structured products",
            "indexation",
            "rate of return",
            "financial economics",
            "developing economies",
            "expected utility"
        ],
        "authors": [
            {
                "name": "Phelim Boyle",
                "org": "Wilfrid Laurier University, Ontario, Canada N2L 3C5"
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Insurance Mathematics and Economics",
        "year": 2008
    },
    "qLtjuiTF": {
        "id": "qLtjuiTF",
        "title": "The Review of Financial Studies",
        "abstract": "",
        "keywords": [
            "and lu zhang 1339 forecasting default with the merton distance to default model sreedhar t. bharath and tyler shumway 1371 who monitors the monitor? the effect of board independence on executive compensation and firm value praveen kumar and k. sivaramakrishnan 1403 does capital account liberalization lead to growth? dennis p. quinn and a. maria toyoda",
            "murillo campello",
            "long chen"
        ],
        "authors": [
            {
                "name": "Praveen Kumar",
                "org": ""
            },
            {
                "name": "Sorin M. Sorescu",
                "org": ""
            },
            {
                "name": "Rodney D. Boehme",
                "org": ""
            },
            {
                "name": "Bartley R.",
                "org": ""
            },
            {
                "name": "Phelim Boyle",
                "org": ""
            },
            {
                "name": "Shui Feng",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Tan Wang",
                "org": ""
            },
            {
                "name": "Soeren Hvidkjaer",
                "org": ""
            },
            {
                "name": "Robin Greenwood",
                "org": ""
            },
            {
                "name": "Robert F. Engle",
                "org": ""
            },
            {
                "name": "Jose Gonzalo Rangel",
                "org": ""
            }
        ],
        "venue": "",
        "year": 0
    },
    "u2xAhTly": {
        "id": "u2xAhTly",
        "title": "Chapter 24 Large Deviation Techniques and Financial Applications",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Phelim Boyle",
                "org": "School of Accountancy, University of Waterloo, Ontario, Canada N2L 3G1"
            },
            {
                "name": "Shui Feng",
                "org": "School of Accountancy, University of Waterloo, Ontario, Canada N2L 3G1"
            },
            {
                "name": "Weidong Tian",
                "org": "School of Accountancy, University of Waterloo, Ontario, Canada N2L 3G1"
            }
        ],
        "venue": "Handbooks in Operations Research and Management Science",
        "year": 2007
    },
    "hcB9y0ki": {
        "id": "hcB9y0ki",
        "title": "EXECUTIVE STOCK OPTIONS: A FIRM VALUE APPROACH",
        "abstract": "Executive stock options are an important component of executive compensation and the topic is of interest to both practitioners and academics. The vigorous debate on whether these options should be treated as an expense is subsiding but discussion continues on how these instruments should be valued in order to expense them. In this paper, executive stock options are viewed as contingent claims on a firm's assets and we formalize this through the concept of an augmented balance sheet. This means that the total market value of the firm's assets is equal to the market value of its traded securities plus the market value of its stock options. This approach leads to two valuation formulae for these options: one in terms of the firm's stock price and the other in terms of firm value. We explore the connections between these two approaches and derive explicit valuation formulae under certain assumptions.",
        "keywords": [
            "dilution.",
            "valuation",
            "executive stock options"
        ],
        "authors": [
            {
                "name": "PHELIM BOYLE",
                "org": ""
            },
            {
                "name": "WEIDONG TIAN",
                "org": ""
            }
        ],
        "venue": "Journal of Derivatives Accounting",
        "year": 2005
    },
    "3fc7u0Av": {
        "id": "3fc7u0Av",
        "title": "Comparative genomics study of polyhydroxyalkanoates (PHA) and ectoine relevant genes from Halomonas sp. TD01 revealed extensive horizontal gene transfer events and co-evolutionary relationships.",
        "abstract": "Halophilic bacteria have shown their significance in industrial production of polyhydroxyalkanoates (PHA) and are gaining more attention for genetic engineering modification. Yet, little information on the genomics and PHA related genes from halophilic bacteria have been disclosed so far.The draft genome of moderately halophilic bacterium, Halomonas sp. TD01, a strain of great potential for industrial production of short-chain-length polyhydroxyalkanoates (PHA), was analyzed through computational methods to reveal the osmoregulation mechanism and the evolutionary relationship of the enzymes relevant to PHA and ectoine syntheses. Genes involved in the metabolism of PHA and osmolytes were annotated and studied in silico. Although PHA synthase, depolymerase, regulator/repressor and phasin were all involved in PHA metabolic pathways, they demonstrated different horizontal gene transfer (HGT) events between the genomes of different strains. In contrast, co-occurrence of ectoine genes in the same genome was more frequently observed, and ectoine genes were more likely under coincidental horizontal gene transfer than PHA related genes. In addition, the adjacent organization of the homologues of PHA synthase phaC1 and PHA granule binding protein phaP was conserved in the strain TD01, which was also observed in some halophiles and non-halophiles exclusively from \u03b3-proteobacteria. In contrast to haloarchaea, the proteome of Halomonas sp. TD01 did not show obvious inclination towards acidity relative to non-halophilic Escherichia coli MG1655, which signified that Halomonas sp. TD01 preferred the accumulation of organic osmolytes to ions in order to balance the intracellular osmotic pressure with the environment.The accessibility of genome information would facilitate research on the genetic engineering of halophilic bacteria including Halomonas sp. TD01.",
        "keywords": [
            "osmolytes",
            "phac",
            "polyhydroxyalkanoates",
            "genome",
            "halomonas spp.",
            "phb",
            "factories",
            "genomics",
            "biotechnology",
            "sequence alignment",
            "amino acid sequence",
            "phylogeny",
            "cell",
            "microbial"
        ],
        "authors": [
            {
                "name": "Lei Cai",
                "org": "Fudan University School of Life Sciences(School of Life Sciences),Shanghai,China"
            },
            {
                "name": "Dan Tan",
                "org": "Fudan University School of Life Sciences(School of Life Sciences),Shanghai,China"
            },
            {
                "name": "Gulsimay Aibaidula",
                "org": "Xinjiang University(Xinjiang University),Urumqi,China"
            },
            {
                "name": "Xin-Ran Dong",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Jin-Chun Chen",
                "org": "Fudan University School of Life Sciences(School of Life Sciences),Shanghai,China"
            },
            {
                "name": "Wei-Dong Tian",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Guo-Qiang Chen",
                "org": "Fudan University School of Life Sciences(School of Life Sciences),Shanghai,China"
            }
        ],
        "venue": "Microbial cell factories",
        "year": 2011
    },
    "Y65KLcDr": {
        "id": "Y65KLcDr",
        "title": "Functional-network-based gene set analysis using gene-ontology.",
        "abstract": "To account for the functional non-equivalence among a set of genes within a biological pathway when performing gene set analysis, we introduce GOGANPA, a network-based gene set analysis method, which up-weights genes with functions relevant to the gene set of interest. The genes are weighted according to its degree within a genome-scale functional network constructed using the functional annotations available from the gene ontology database. By benchmarking GOGANPA using a well-studied P53 data set and three breast cancer data sets, we will demonstrate the power and reproducibility of our proposed method over traditional unweighted approaches and a competing network-based approach that involves a complex integrated network. GOGANPA's sole reliance on gene ontology further allows GOGANPA to be widely applicable to the analysis of any gene-ontology-annotated genome.",
        "keywords": [
            "chemistry",
            "medicine",
            "biology",
            "engineering",
            "gene expression profiling",
            "gene regulatory networks",
            "physics"
        ],
        "authors": [
            {
                "name": "Billy Chang",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Rafal Kustra",
                "org": "University of Toronto(University of Toronto),Toronto,Canada"
            },
            {
                "name": "Weidong Tian",
                "org": "Fudan University(Fudan University),Shanghai,China"
            }
        ],
        "venue": "PloS one",
        "year": 2013
    },
    "06rA5oN6": {
        "id": "06rA5oN6",
        "title": "Integration of cancer gene co-expression network and metabolic network to uncover potential cancer drug targets.",
        "abstract": "Cell metabolism is critical for cancer cell transformation and progression. In this study, we have developed a novel method, named Met-express, that integrates a cancer gene co-expression network with the metabolic network to predict key enzyme-coding genes and metabolites in cancer cell metabolism. Met-express successfully identified a group of key enzyme-coding genes and metabolites in lung, leukemia, and breast cancers. Literature reviews suggest that approximately 33-53% of the predicted genes are either known or suggested anti-cancer drug targets, while 22% of the predicted metabolites are known or high-potential drug compounds in therapeutic use. Furthermore, experimental validations prove that 90% of the selected genes and 70% of metabolites demonstrate the significant anti-cancer phenotypes in cancer cells, implying that they may play important roles in cancer metabolism. Therefore, Met-express is a powerful tool for uncovering novel therapeutic biomarkers.",
        "keywords": [
            "metabolism",
            "metabolic network",
            "drug targets",
            "cancer",
            "network integration",
            "gene co-expression network"
        ],
        "authors": [
            {
                "name": "Jingqi Chen",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Ming Ma",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Ning Shen",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Jianzhong Jeff Xi",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Fudan University(Fudan University),Shanghai,China"
            }
        ],
        "venue": "Journal of proteome research",
        "year": 2013
    },
    "FrOs6NcI": {
        "id": "FrOs6NcI",
        "title": "Combining Hi-C data with phylogenetic correlation to predict the target genes of distal regulatory elements in human genome.",
        "abstract": "Defining the target genes of distal regulatory elements (DREs), such as enhancer, repressors and insulators, is a challenging task. The recently developed Hi-C technology is designed to capture chromosome conformation structure by high-throughput sequencing, and can be potentially used to determine the target genes of DREs. However, Hi-C data are noisy, making it difficult to directly use Hi-C data to identify DRE-target gene relationships. In this study, we show that DREs-gene pairs that are confirmed by Hi-C data are strongly phylogenetic correlated, and have thus developed a method that combines Hi-C read counts with phylogenetic correlation to predict long-range DRE-target gene relationships. Analysis of predicted DRE-target gene pairs shows that genes regulated by large number of DREs tend to have essential functions, and genes regulated by the same DREs tend to be functionally related and co-expressed. In addition, we show with a couple of examples that the predicted target genes of DREs can help explain the causal roles of disease-associated single-nucleotide polymorphisms located in the DREs. As such, these predictions will be of importance not only for our understanding of the function of DREs but also for elucidating the causal roles of disease-associated noncoding single-nucleotide polymorphisms.",
        "keywords": [
            "phylogeny",
            "gene expression regulation"
        ],
        "authors": [
            {
                "name": "Yulan Lu",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Yuanpeng Zhou",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Fudan University(Fudan University),Shanghai,China"
            }
        ],
        "venue": "Nucleic acids research",
        "year": 2013
    },
    "GlEQOlvd": {
        "id": "GlEQOlvd",
        "title": "Regulation of mRNA splicing by MeCP2 via epigenetic modifications in the brain",
        "abstract": "A Nature Research Journal",
        "keywords": "",
        "authors": [
            {
                "name": "Tian-Lin Cheng",
                "org": "Institute of Neuroscience, Key Laboratory of Primate Neurobiology, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai, 200031, China"
            },
            {
                "name": "Zilong Qiu",
                "org": "Institute of Neuroscience, Key Laboratory of Primate Neurobiology, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai, 200031, China"
            },
            {
                "name": "Jingqi Chen",
                "org": "Department of Biostatistics and Computational Biology, School of Life Science, Fudan University, Shanghai, 200436, China"
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Biostatistics and Computational Biology, School of Life Science, Fudan University, Shanghai, 200436, China"
            },
            {
                "name": "Huida Wan",
                "org": "Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China"
            },
            {
                "name": "Bin Tang",
                "org": "Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China"
            },
            {
                "name": "Lujian Liao",
                "org": "Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China"
            }
        ],
        "venue": "Scientific Reports",
        "year": 2017
    },
    "5NglWiIp": {
        "id": "5NglWiIp",
        "title": "Revealing of Mycobacterium marinum transcriptome by RNA-seq.",
        "abstract": "Transcriptome analysis has played an essential role for revealing gene expression and the complexity of regulations at transcriptional level. RNA-seq is a powerful tool for transcriptome profiling, which uses deep-sequencing technologies to directly determine the cDNA sequence. Here, we utilized RNA-seq to explore the transcriptome of Mycobacteriummarinum (M. marinum), which is a useful model to study the pathogenesis of Mycobacterium tuberculosis (Mtb). Two profiles of exponential and early stationary phase cultures were generated after a physical ribosome RNA removal step. We systematically described the transcriptome and analyzed the functions for the differentiated expressed genes between the two phases. Furthermore, we predicted 360 operons throughout the whole genome, and 13 out of 17 randomly selected operons were validated by qRT-PCR. In general, our study has primarily uncovered M. marinum transcriptome, which could help to gain a better understanding of the regulation system in Mtb that underlines disease pathogenesis.",
        "keywords": [
            "transcriptome",
            "medicine",
            "chemistry",
            "gene expression profiling",
            "engineering",
            "operon",
            "biology",
            "physics",
            "real time polymerase chain reaction"
        ],
        "authors": [
            {
                "name": "Sen Wang",
                "org": "Fudan University Shanghai Medical College(^ Shanghai Medical College of Fudan University),Shanghai,China"
            },
            {
                "name": "Xinran Dong",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Yongqiang Zhu",
                "org": "Chinese National Human Genome Center at Shanghai(Chinese National Human Genome Center,Chinese National Human Genome Center at Shanghai),Shanghai,China"
            },
            {
                "name": "Chuan Wang",
                "org": "Fudan University Shanghai Medical College(^ Shanghai Medical College of Fudan University),Shanghai,China"
            },
            {
                "name": "Gang Sun",
                "org": "Fudan University Shanghai Medical College(^ Shanghai Medical College of Fudan University),Shanghai,China"
            },
            {
                "name": "Tao Luo",
                "org": "Fudan University Shanghai Medical College(^ Shanghai Medical College of Fudan University),Shanghai,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Huajun Zheng",
                "org": "Chinese National Human Genome Center at Shanghai(Chinese National Human Genome Center,Chinese National Human Genome Center at Shanghai),Shanghai,China"
            },
            {
                "name": "Qian Gao",
                "org": "Fudan University Shanghai Medical College(^ Shanghai Medical College of Fudan University),Shanghai,China"
            }
        ],
        "venue": "PloS one",
        "year": 2013
    },
    "pprLDNX5": {
        "id": "pprLDNX5",
        "title": "SAP--a sequence mapping and analyzing program for long sequence reads alignment and accurate variants discovery.",
        "abstract": "The third-generation of sequencing technologies produces sequence reads of 1000 bp or more that may contain high polymorphism information. However, most currently available sequence analysis tools are developed specifically for analyzing short sequence reads. While the traditional Smith-Waterman (SW) algorithm can be used to map long sequence reads, its naive implementation is computationally infeasible. We have developed a new Sequence mapping and Analyzing Program (SAP) that implements a modified version of SW to speed up the alignment process. In benchmarks with simulated and real exon sequencing data and a real E. coli genome sequence data generated by the third-generation sequencing technologies, SAP outperforms currently available tools for mapping short and long sequence reads in both speed and proportion of captured reads. In addition, it achieves high accuracy in detecting SNPs and InDels in the simulated data. SAP is available at https://github.com/davidsun/SAP.",
        "keywords": [
            "engineering",
            "physics",
            "chemistry",
            "medicine",
            "mutation",
            "algorithms",
            "computer simulation",
            "biology",
            "sequence alignment"
        ],
        "authors": [
            {
                "name": "Zheng Sun",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Fudan University(Fudan University),Shanghai,China"
            }
        ],
        "venue": "PloS one",
        "year": 2012
    },
    "2Ek4nFNw": {
        "id": "2Ek4nFNw",
        "title": "The effect of multiple single nucleotide polymorphisms in the folic acid pathway genes on homocysteine metabolism.",
        "abstract": "To investigate the joint effects of the single nucleotide polymorphisms (SNPs) of genes in the folic acid pathway on homocysteine (Hcy) metabolism.Four hundred women with normal pregnancies were enrolled in this study. SNPs were identified by MassARRAY. Serum folic acid and Hcy concentration were measured. Analysis of variance (ANOVA) and support vector machine (SVM) regressions were used to analyze the joint effects of SNPs on the Hcy level.SNPs of MTHFR (rs1801133 and rs3733965) were significantly associated with maternal serum Hcy level. In the different genotypes of MTHFR (rs1801133), SNPs of RFC1 (rs1051266), TCN2 (rs9606756), BHMT (rs3733890), and CBS (rs234713 and rs2851391) were linked with the Hcy level adjusted for folic acid concentration. The integrated SNPs scores were significantly associated with the residual Hcy concentration (RHC) (r = 0.247). The Hcy level was significantly higher in the group with high SNP scores than that in other groups with SNP scores of less than 0.2 (P = 0.000). Moreover, this difference was even more significant in moderate and high levels of folic acid.SNPs of genes in the folic acid pathway possibly affect the Hcy metabolism in the presence of moderate and high levels of folic acid.",
        "keywords": [],
        "authors": [
            {
                "name": "Shuang Liang",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Yuanpeng Zhou",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Huijun Wang",
                "org": "Shanghai Children's Medical Center(Shanghai Children's Hospital,Children's Hospital of Fudan University,Shanghai Children's Medical Center),Shanghai,China"
            },
            {
                "name": "Yanyan Qian",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Duan Ma",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Vishwani Persaud-Sharma",
                "org": "University of South Florida Tampa(University of South Florida),Tampa,United States"
            },
            {
                "name": "Chen Yu",
                "org": "Shanghai Xuhui Central Hospital(Shanghai Xuhui Central Hospital),Shanghai,China"
            },
            {
                "name": "Yunyun Ren",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Shufeng Zhou",
                "org": "University of South Florida Tampa(University of South Florida),Tampa,United States"
            },
            {
                "name": "Xiaotian Li",
                "org": "Fudan University(Fudan University),Shanghai,China"
            }
        ],
        "venue": "BioMed research international",
        "year": 2014
    },
    "6pyxkMJa": {
        "id": "6pyxkMJa",
        "title": "Predicting Gene Function Using Omics Data: From Data Preparation to Data Integration",
        "abstract": "\n In the post-genomic era, the continuing development of high-throughput technologies has led to the explosion of enormous amount\n of omics data, ranging from genomics, transcriptomics, proteomics, metabolomics, to phenomics. Integration of diverse omics\n data can help us to understand the complete functions of genes in the cell. However, the complexity, heterogeneity, and large-scale\n of the omics data have created significant challenges to the gene function prediction field. Currently, the focus of this\n field is to develop efficient and accurate algorithms to integrate omics data for predicting gene function. In this chapter,\n we first introduce the various types of omics data, and how they relate to gene functions. Then, we review current algorithms\n available for integrating omics data for gene function predictions. Next, we use a combined algorithm named Funckenstein as\n an example to further illustrate the integration process. In the final two sections, we discuss current limitations and potential\n improvements of this field, and offer perspectives for future directions.\n \n ",
        "keywords": [],
        "authors": [
            {
                "name": "Weidong Tian",
                "org": "School of Life Sciences, Fudan University, Shanghai, China"
            },
            {
                "name": "Xinran Dong",
                "org": "School of Life Sciences, Fudan University, Shanghai, China"
            },
            {
                "name": "Yuanpeng Zhou",
                "org": "School of Life Sciences, Fudan University, Shanghai, China"
            },
            {
                "name": "Ren Ren",
                "org": "School of Life Sciences, Fudan University, Shanghai, China"
            }
        ],
        "venue": "",
        "year": 2011
    },
    "HCA0bvLq": {
        "id": "HCA0bvLq",
        "title": "Molecular mechanisms and function prediction of long noncoding RNA.",
        "abstract": "The central dogma of gene expression considers RNA as the carrier of genetic information from DNA to protein. However, it has become more and more clear that RNA plays more important roles than simply being the information carrier. Recently, whole genome transcriptomic analyses have identified large numbers of dynamically expressed long noncoding RNAs (lncRNAs), many of which are involved in a variety of biological functions. Even so, the functions and molecular mechanisms of most lncRNAs still remain elusive. Therefore, it is necessary to develop computational methods to predict the function of lncRNAs in order to accelerate the study of lncRNAs. Here, we review the recent progress in the identification of lncRNAs, the molecular functions and mechanisms of lncRNAs, and the computational methods for predicting the function of lncRNAs.",
        "keywords": [
            "computational biology",
            "transcriptome"
        ],
        "authors": [
            {
                "name": "Handong Ma",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Yun Hao",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Xinran Dong",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Qingtian Gong",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Jingqi Chen",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Jifeng Zhang",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Fudan University(Fudan University),Shanghai,China"
            }
        ],
        "venue": "TheScientificWorldJournal",
        "year": 2012
    },
    "Q0GHrNoM": {
        "id": "Q0GHrNoM",
        "title": "Identification of novel candidate maternal serum protein markers for Down syndrome by integrated proteomic and bioinformatic analysis.",
        "abstract": "This study aimed to identify candidate protein biomarkers from maternal serum for Down syndrome (DS) by integrated proteomic and bioinformatics analysis.A pregnancy DS group of 18 women and a control group with the same number were prepared, and the maternal serum proteins were analyzed by isobaric tags for relative and absolute quantitation and mass spectrometry, to identify DS differentially expressed maternal serum proteins (DS-DEMSPs). Comprehensive bioinformatics analysis was then employed to analyze DS-DEMSPs both in this paper and seven related publications.Down syndrome differentially expressed maternal serum proteins from different studies are significantly enriched with common Gene Ontology functions, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, transcription factor binding sites, and Pfam protein domains, However, the DS-DEMSPs are less functionally related to known DS-related genes. These evidences suggest that common molecular mechanisms induced by secondary effects may be present upon DS carrying. A simple scoring scheme revealed Alpha-2-macroglobulin, Apolipoprotein A1, Apolipoprotein E, Complement C1s subcomponent, Complement component 5, Complement component 8, alpha polypeptide, Complement component 8, beta polypeptide and Fibronectin as potential DS biomarkers.The integration of proteomics and bioinformatics studies provides a novel approach to develop new prenatal screening methods for noninvasive yet accurate diagnosis of DS.",
        "keywords": [
            "fetal and placental pathology",
            "biomarkers",
            "down syndrome",
            "prenatal screening",
            "proteomics",
            "bioinformatics"
        ],
        "authors": [
            {
                "name": "Yuan Kang",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Xinran Dong",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Qiongjie Zhou",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Ying Zhang",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Yan Cheng",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Rong Hu",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Cuihong Su",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Hong Jin",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Xiaohui Liu",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Duan Ma",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Xiaotian Li",
                "org": "Fudan University(Fudan University),Shanghai,China"
            }
        ],
        "venue": "Prenatal diagnosis",
        "year": 2012
    },
    "2vUBj6QX": {
        "id": "2vUBj6QX",
        "title": "Dynamic population changes in Mycobacterium tuberculosis during acquisition and fixation of drug resistance in patients.",
        "abstract": "Drug-resistant tuberculosis poses a growing challenge to global public health. However, the diversity and dynamics of the bacterial population during acquisition of drug resistance have yet to be carefully examined.Whole-genome sequencing was performed on 7 serial Mycobacterium tuberculosis (M. tuberculosis) populations from 3 patients during different stages in the development of drug resistance. The population diversity was assessed by the number and frequencies of unfixed mutations in each sample.For each bacterial population, 8-41 unfixed mutations were monitored by the fraction of single-nucleotide polymorphisms at specific loci. Among them, as many as 4 to 5 resistance-conferring mutations were transiently detected in the same single sputum, but ultimately only a single type of mutant was fixed. In addition, we identified 14 potential compensatory mutations that occurred during or after the emergence of resistance-conferring mutations.M. tuberculosis population within patients exhibited considerable genetic diversity, which underwent selections for most fit resistant mutant. These findings have important implications and emphasize the need for early diagnosis of tuberculosis to decrease the chance of evolving highly fit drug-resistant strains.",
        "keywords": [
            "mutation"
        ],
        "authors": [
            {
                "name": "Gang Sun",
                "org": "Fudan University Shanghai Medical College(^ Shanghai Medical College of Fudan University),Shanghai,China"
            },
            {
                "name": "Tao Luo",
                "org": "Fudan University Shanghai Medical College(^ Shanghai Medical College of Fudan University),Shanghai,China"
            },
            {
                "name": "Chongguang Yang",
                "org": "Fudan University Shanghai Medical College(^ Shanghai Medical College of Fudan University),Shanghai,China"
            },
            {
                "name": "Xinran Dong",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Jing Li",
                "org": "Shanghai Municipal Center for Disease Control and Prevention(Shanghai Municipal Center for Disease Control and Prevention),Shanghai,China"
            },
            {
                "name": "Yongqiang Zhu",
                "org": "Chinese National Human Genome Center at Shanghai(Chinese National Human Genome Center,Chinese National Human Genome Center at Shanghai),Shanghai,China"
            },
            {
                "name": "Huajun Zheng",
                "org": "Chinese National Human Genome Center at Shanghai(Chinese National Human Genome Center,Chinese National Human Genome Center at Shanghai),Shanghai,China"
            },
            {
                "name": "Weidong Tian",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Shengyue Wang",
                "org": "Chinese National Human Genome Center at Shanghai(Chinese National Human Genome Center,Chinese National Human Genome Center at Shanghai),Shanghai,China"
            },
            {
                "name": "Clifton E Barry",
                "org": "National Institute of Allergy and Infectious Diseases(National Institute of Allergy and Infectious Diseases,NIH,NIAID,Natl. Inst. Allerg. and Infect. Dis.),Bethesda,United States"
            },
            {
                "name": "Jian Mei",
                "org": "Shanghai Municipal Center for Disease Control and Prevention(Shanghai Municipal Center for Disease Control and Prevention),Shanghai,China"
            },
            {
                "name": "Qian Gao",
                "org": "Fudan University Shanghai Medical College(^ Shanghai Medical College of Fudan University),Shanghai,China"
            }
        ],
        "venue": "The Journal of infectious diseases",
        "year": 2012
    },
    "hIT0uo63": {
        "id": "hIT0uo63",
        "title": "A Resource of Quantitative Functional Annotation for Homo sapiens Genes.",
        "abstract": "The body of human genomic and proteomic evidence continues to grow at ever-increasing rates, while annotation efforts struggle to keep pace. A surprisingly small fraction of human genes have clear, documented associations with specific functions, and new functions continue to be found for characterized genes. Here we assembled an integrated collection of diverse genomic and proteomic data for 21,341 human genes and make quantitative associations of each to 4333 Gene Ontology terms. We combined guilt-by-profiling and guilt-by-association approaches to exploit features unique to the data types. Performance was evaluated by cross-validation, prospective validation, and by manual evaluation with the biological literature. Functional-linkage networks were also constructed, and their utility was demonstrated by identifying candidate genes related to a glioma FLN using a seed network from genome-wide association studies. Our annotations are presented-alongside existing validated annotations-in a publicly accessible and searchable web interface.",
        "keywords": [
            "gene function human",
            "function prediction",
            "gene ontology",
            "machine learning",
            "data type",
            "candidate gene",
            "web interface",
            "genome wide association study",
            "cross validation",
            "human genome"
        ],
        "authors": [
            {
                "name": "Murat Ta\u015fan",
                "org": "University of Toronto(University of Toronto),Toronto,Canada"
            },
            {
                "name": "Harold J Drabkin",
                "org": "Jackson Laboratory(Jackson Laboratory,The Jackson Laboratory,Jackson Lab.),Bar Harbor,United States"
            },
            {
                "name": "John E Beaver",
                "org": "Harvard Medical School(Harvard Medical School,Harvard Med. Sch.),Boston,United States"
            },
            {
                "name": "Hon Nian Chua",
                "org": "University of Toronto(University of Toronto),Toronto,Canada"
            },
            {
                "name": "Julie Dunham",
                "org": "University of Toronto(University of Toronto),Toronto,Canada"
            },
            {
                "name": "Weidong Tian",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Judith A Blake",
                "org": "Jackson Laboratory(Jackson Laboratory,The Jackson Laboratory,Jackson Lab.),Bar Harbor,United States"
            },
            {
                "name": "Frederick P Roth",
                "org": "University of Toronto(University of Toronto),Toronto,Canada"
            }
        ],
        "venue": "G3 (Bethesda, Md.)",
        "year": 2012
    },
    "M9TO0rmC": {
        "id": "M9TO0rmC",
        "title": "Adenoid cystic carcinoma of the head and neck: clinicopathologic analysis of 218 cases in a Chinese population.",
        "abstract": "The aim of this study was to analyze the clinicopathologic characteristics and prognostic factors of adenoid cystic carcinoma of the head and neck (ACCHN).This was a retrospective study of 218 patients with ACCHN.The cohort included 110 men and 108 women; the parotid and the palate were the most common site of involvement. Of 203 patients with follow-up information (range 2-132 months), 57 had died of the tumor. Distant metastasis (DM) and local recurrence (LR) were documented in 83 (40.9%) and 34 (16.7%) patients, respectively. Cox regression analysis indicated that a solid pattern was a marker for LR and that positive margins and older age were risk factors for DM. Histologic pattern, T stage, N stage, LR, DM, and patient age contributed to the prediction of disease-specific survival.A solid pattern, metastasis, LR, and older age are the most important factors for predicting poor prognosis in Chinese patients with ACCHN.",
        "keywords": [],
        "authors": [
            {
                "name": "Chun-Ye Zhang",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Rong-Hui Xia",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Jing Han",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Bing-Shun Wang",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Wei-Dong Tian",
                "org": "Fudan University(Fudan University),Shanghai,China"
            },
            {
                "name": "Lai-Ping Zhong",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Zhen Tian",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Li-Zhen Wang",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Yu-Hua Hu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Jiang Li",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            }
        ],
        "venue": "Oral surgery, oral medicine, oral pathology and oral radiology",
        "year": 2013
    },
    "KA6WfyGp": {
        "id": "KA6WfyGp",
        "title": "An iterative network partition algorithm for accurate identification of dense network modules.",
        "abstract": "A key step in network analysis is to partition a complex network into dense modules. Currently, modularity is one of the most popular benefit functions used to partition network modules. However, recent studies suggested that it has an inherent limitation in detecting dense network modules. In this study, we observed that despite the limitation, modularity has the advantage of preserving the primary network structure of the undetected modules. Thus, we have developed a simple iterative Network Partition (iNP) algorithm to partition a network. The iNP algorithm provides a general framework in which any modularity-based algorithm can be implemented in the network partition step. Here, we tested iNP with three modularity-based algorithms: multi-step greedy (MSG), spectral clustering and Qcut. Compared with the original three methods, iNP achieved a significant improvement in the quality of network partition in a benchmark study with simulated networks, identified more modules with significantly better enrichment of functionally related genes in both yeast protein complex network and breast cancer gene co-expression network, and discovered more cancer-specific modules in the cancer gene co-expression network. As such, iNP should have a broad application as a general method to assist in the analysis of biological networks.",
        "keywords": [
            "gene regulatory networks",
            "gene expression",
            "algorithms"
        ],
        "authors": [
            {
                "name": "Siqi Sun",
                "org": "State Key Laboratory of Genetic Engineering, Institute of Biostatistics, School of Life Sciences, Fudan University, Shanghai 200433, PR China."
            },
            {
                "name": "Xinran Dong",
                "org": ""
            },
            {
                "name": "Yao Fu",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            }
        ],
        "venue": "Nucleic acids research",
        "year": 2012
    },
    "31UPjbsl": {
        "id": "31UPjbsl",
        "title": "Short-term and continuing stresses differentially interplay with multiple hormones to regulate plant survival and growth.",
        "abstract": "The stress phytohormone, abscisic acid (ABA), plays important roles in facilitating plants to survive and grow well under a wide range of stress conditions. Previous gene expression studies mainly focused on plant responses to short-term ABA treatment, but the effect of sustained ABA treatment and their difference are poorly studied. Here, we treated plants with ABA for 1 h or 9 d, and our genome-wide analysis indicated the differentially regulated genes under the two conditions were tremendously different. We analyzed other hormones' signaling changes by using their whole sets of known responsive genes as reporters and integrating feedback regulation of their biosynthesis. We found that, under short-term ABA treatment, signaling outputs of growth-promoting hormones, brassinosteroids and gibberellins, and a biotic stress-responsive hormone, jasmonic acid, were significantly inhibited, while auxin and ethylene signaling outputs were promoted. However, sustained ABA treatment repressed cytokinin and gibberellin signaling, but stimulated auxin signaling. Using several sets of hormone-related mutants, we found candidates in corresponding hormonal signaling pathways, including receptors or transcription regulators, are essential in responding to ABA. Our findings indicate interactions of ABA-dependent stress signals with hormones at different levels are involved in plants to survive under transient stress and to adapt to continuing stressful environments.",
        "keywords": [
            "abscisic acid",
            "continuing stress",
            "crosstalk",
            "phytohormone",
            "short-term stress",
            "survival and growth."
        ],
        "authors": [
            {
                "name": "Cangjing Yang",
                "org": "a State Key Laboratory of Genetic Engineering, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, 200433, P.R. China."
            },
            {
                "name": "Jingjing Liu",
                "org": ""
            },
            {
                "name": "Xinran Dong",
                "org": ""
            },
            {
                "name": "Zhenying Cai",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Xuelu Wang",
                "org": ""
            }
        ],
        "venue": "Molecular plant",
        "year": 2014
    },
    "zLGBX9Wn": {
        "id": "zLGBX9Wn",
        "title": "microRNA expression profiling of heart tissue during fetal development.",
        "abstract": "microRNAs (miRNAs) are important both in early cardiogenesis and in the process of heart maturation. The aim of this study was to determine the stage-specific expression of miRNAs in human fetal heart in order to identify valuable targets for further study of heart defects. Affymetrix microarrays were used to obtain miRNA expression profiles from human fetal heart tissue at 5, 7, 9 and 23 weeks of gestation. To identify differentially expressed miRNAs at each time-point, linear regression analysis by the R limma algorithm was employed. Hierarchical clustering analysis was conducted with Cluster 3.0 software. Gene Ontology analysis was carried out for miRNAs from different clusters. Commonalities in miRNA families and genomic localization were identified, and the differential expression of selected miRNAs from different clusters was verified by quantitative polymerase chain reaction (qPCR). A total of 703 miRNAs were expressed in human fetal heart. Of these, 288 differentially expressed miRNAs represented 5 clusters with different expression trends. Several clustered miRNAs also shared classification within miRNA families or proximal genomic localization. qPCR confirmed the expression patterns of selected miRNAs. miRNAs within the 5 clusters were predicted to target genes vital for heart development and to be involved in cellular signaling pathways that affect heart structure formation and heart-associated cellular events. In conclusion, to the best of our knowledge, this is the first miRNA expression profiling study of human fetal heart tissue. The stage-specific expression of specific miRNAs suggests potential roles at distinct time-points during fetal heart development.",
        "keywords": [
            "molecular medicine",
            "cell cycle",
            "apoptosis",
            "oncology",
            "cancer",
            "gene",
            "cell"
        ],
        "authors": [
            {
                "name": "Jizi Zhou",
                "org": "Obstetrics and Gynecology Hospital, Fudan University, Shanghai, P.R. China."
            },
            {
                "name": "Xinran Dong",
                "org": "Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University, Shanghai, P.R. China."
            },
            {
                "name": "Qiongjie Zhou",
                "org": "Obstetrics and Gynecology Hospital, Fudan University, Shanghai, P.R. China."
            },
            {
                "name": "Huijun Wang",
                "org": "Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, P.R. China."
            },
            {
                "name": "Yanyan Qian",
                "org": "Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, P.R. China."
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University, Shanghai, P.R. China."
            },
            {
                "name": "Duan Ma",
                "org": "Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, P.R. China."
            },
            {
                "name": "Xiaotian Li",
                "org": "Obstetrics and Gynecology Hospital, Fudan University, Shanghai, P.R. China."
            }
        ],
        "venue": "International journal of molecular medicine",
        "year": 2014
    },
    "MF412zu5": {
        "id": "MF412zu5",
        "title": "Cellulose synthesis genes CESA6 and CSI1 are important for salt stress tolerance in Arabidopsis.",
        "abstract": "Soil salinity is a widespread abiotic stress constraint threatening agricultural production, as it severely inhibits growth and development of crops. Several salt stress signaling pathways have been discovered in the model plant Arabidopsis thaliana, which include components for sensing the stress, transmitting the signal and regulating the downstream genes (Deinlein et al. 2014; Julkowska and Testerink 2015). In nature, plant roots directly encounter heterogeneous soils and therefore their responses to saline environments require dynamic changes in growth, a process in which plant cell walls play important roles (Tenhaken 2015).",
        "keywords": [],
        "authors": [
            {
                "name": "Shuang-Shuang Zhang",
                "org": "State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai, 200433, China."
            },
            {
                "name": "Le Sun",
                "org": "State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai, 200433, China."
            },
            {
                "name": "Xinran Dong",
                "org": "Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University, Shanghai, 200433, China."
            },
            {
                "name": "Sun-Jie Lu",
                "org": "State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai, 200433, China."
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University, Shanghai, 200433, China."
            },
            {
                "name": "Jian-Xiang Liu",
                "org": "State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai, 200433, China."
            }
        ],
        "venue": "Journal of integrative plant biology",
        "year": 2015
    },
    "Mw3dMYNn": {
        "id": "Mw3dMYNn",
        "title": "LEGO: a novel method for gene set over-representation analysis by incorporating network-based gene weights.",
        "abstract": "Pathway or gene set over-representation analysis (ORA) has become a routine task in functional genomics studies. However, currently widely used ORA tools employ statistical methods such as Fisher's exact test that reduce a pathway into a list of genes, ignoring the constitutive functional non-equivalent roles of genes and the complex gene-gene interactions. Here, we develop a novel method named LEGO (functional Link Enrichment of Gene Ontology or gene sets) that takes into consideration these two types of information by incorporating network-based gene weights in ORA analysis. In three benchmarks, LEGO achieves better performance than Fisher and three other network-based methods. To further evaluate LEGO's usefulness, we compare LEGO with five gene expression-based and three pathway topology-based methods using a benchmark of 34 disease gene expression datasets compiled by a recent publication, and show that LEGO is among the top-ranked methods in terms of both sensitivity and prioritization for detecting target KEGG pathways. In addition, we develop a cluster-and-filter approach to reduce the redundancy among the enriched gene sets, making the results more interpretable to biologists. Finally, we apply LEGO to two lists of autism genes, and identify relevant gene sets to autism that could not be found by Fisher.",
        "keywords": [],
        "authors": [
            {
                "name": "xiaoyan dong",
                "org": "State Key Laboratory of Genetic Engineering, Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University, Shanghai 200436, P.R. China."
            },
            {
                "name": "yajuan hao",
                "org": "State Key Laboratory of Genetic Engineering, Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University, Shanghai 200436, P.R. China."
            },
            {
                "name": "xiaodong wang",
                "org": "State Key Laboratory of Genetic Engineering, Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University, Shanghai 200436, P.R. China."
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University, Shanghai 100433, P.R. China."
            }
        ],
        "venue": "Scientific reports",
        "year": 2016
    },
    "jiA5fVar": {
        "id": "jiA5fVar",
        "title": "Explaining the disease phenotype of intergenic SNP through predicted long range regulation.",
        "abstract": "Thousands of disease-associated SNPs (daSNPs) are located in intergenic regions (IGR), making it difficult to understand their association with disease phenotypes. Recent analysis found that non-coding daSNPs were frequently located in or approximate to regulatory elements, inspiring us to try to explain the disease phenotypes of IGR daSNPs through nearby regulatory sequences. Hence, after locating the nearest distal regulatory element (DRE) to a given IGR daSNP, we applied a computational method named INTREPID to predict the target genes regulated by the DRE, and then investigated their functional relevance to the IGR daSNP's disease phenotypes. 36.8% of all IGR daSNP-disease phenotype associations investigated were possibly explainable through the predicted target genes, which were enriched with, were functionally relevant to, or consisted of the corresponding disease genes. This proportion could be further increased to 60.5% if the LD SNPs of daSNPs were also considered. Furthermore, the predicted SNP-target gene pairs were enriched with known eQTL/mQTL SNP-gene relationships. Overall, it's likely that IGR daSNPs may contribute to disease phenotypes by interfering with the regulatory function of their nearby DREs and causing abnormal expression of disease genes.",
        "keywords": "",
        "authors": [
            {
                "name": "Jingqi Chen",
                "org": "State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200436, P.R. China Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University, Shanghai 200436, P.R. China."
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200436, P.R. China Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University, Shanghai 200436, P.R. China weidong.tian@fudan.edu.cn."
            }
        ],
        "venue": "Nucleic acids research",
        "year": 2016
    },
    "Z8omrrgu": {
        "id": "Z8omrrgu",
        "title": "China's community-based strategy of universal preconception care in rural areas at a population level using a novel risk classification system for stratifying couples\u00b4 preconception health status.",
        "abstract": "This project provided new insights into preconception health of Chinese couples of reproductive age. More than half of the male partners planning to father a child, were exposed to risk factors during the preconception period, suggesting that an integrated approach to PCC including both women and men is justified. Stratification based on the new risk classification model demonstrated that a majority of the risk factors are avoidable, or preventable by medical intervention. Therefore, universal free PCC can be expected to improve pregnancy outcomes in rural China.",
        "keywords": [
            "Community-based care",
            "Population-based study",
            "Preconception care",
            "Preconception health",
            "Reproductive health",
            "Risk stratification",
            "Rural China",
            "Universal preconception care"
        ],
        "authors": [
            {
                "name": "Qiongjie Zhou",
                "org": "Women's Health and Perinatology Research Group, Department of Clinical Medicine, UiT - The Arctic University of Norway, Troms\u00f8, Norway."
            },
            {
                "name": "Shikun Zhang",
                "org": "The National Health and Family Planning Commission, Beijing, China. yiping791129@163.com."
            },
            {
                "name": "Qiaomei Wang",
                "org": "The National Health and Family Planning Commission, Beijing, China."
            },
            {
                "name": "Haiping Shen",
                "org": "The National Health and Family Planning Commission, Beijing, China."
            },
            {
                "name": "Weidong Tian",
                "org": "School of Life Sciences, Institute of Biostatistics, Fudan University, Shanghai, China."
            },
            {
                "name": "Jingqi Chen",
                "org": "School of Life Sciences, Institute of Biostatistics, Fudan University, Shanghai, China."
            },
            {
                "name": "Ganesh Acharya",
                "org": "Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institute, Stockholm, Sweden."
            },
            {
                "name": "Xiaotian Li",
                "org": "Institute of Biomedical Sciences, Fudan University, Shanghai, China. xiaotianli555@163.com."
            }
        ],
        "venue": "BMC health services research",
        "year": 2016
    },
    "41p5iwKm": {
        "id": "41p5iwKm",
        "title": "Assessment of preconception risk factors after China's National Free Preconception Health Examination Project",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Qiongjie Zhou",
                "org": ""
            },
            {
                "name": "Shikun Zhang",
                "org": ""
            },
            {
                "name": "Xiaomei Wang",
                "org": ""
            },
            {
                "name": "Haiping Shen",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Jingqi Chen",
                "org": ""
            },
            {
                "name": "Xiaotian Li",
                "org": ""
            }
        ],
        "venue": "European Journal of Obstetrics & Gynecology and Reproductive Biology",
        "year": 2019
    },
    "A5GW9i6o": {
        "id": "A5GW9i6o",
        "title": "Epigenetic features are significantly associated with alternative splicing.",
        "abstract": "While alternative splicing (AS) contributes greatly to protein diversities, the relationship between various types of AS and epigenetic factors remains largely unknown.In this study, we discover that a number of epigenetic features, including DNA methylation, nucleosome occupancy, specific histone modifications and protein features, are strongly associated with AS. To further enhance our understanding of the association between these features and AS, we cluster our investigated features based on their association patterns with each AS type into four groups, with H3K36me3, EGR1, GABP, SRF, SIN3A and RNA Pol II grouped together and showing strongest association with AS. In addition, we find that the AS types can be classified into two general classes, namely the exon skipping related process (ESRP), and the alternative splice site selection process (ASSP), based on their association levels with the epigenetic features.Our analysis thus suggests that epigenetic features are likely to play important roles in regulating AS.",
        "keywords": [
            "cluster analysis",
            "dna methylation",
            "rna polymerase ii",
            "nucleosomes",
            "alternative splicing",
            "cell line",
            "microarrays",
            "histones",
            "acetylation",
            "proteomics",
            "computational biology",
            "repressor proteins"
        ],
        "authors": [
            {
                "name": "Yuanpeng Zhou",
                "org": "State Key Laboratory of Genetic Engineering, Institute of Biostatistics, School of Life Science, Fudan University, Shanghai, China."
            },
            {
                "name": "Yulan Lu",
                "org": "State Key Laboratory of Genetic Engineering, Institute of Biostatistics, School of Life Science,Fudan University,Shanghai,China"
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Genetic Engineering, Institute of Biostatistics, School of Life Science,Fudan University,Shanghai,China"
            }
        ],
        "venue": "BMC genomics",
        "year": 2012
    },
    "5nsFFuQP": {
        "id": "5nsFFuQP",
        "title": "SPRINT: an SNP-free toolkit for identifying RNA editing sites.",
        "abstract": "RNA editing generates post-transcriptional sequence alterations. Detection of RNA editing sites (RESs) typically requires the filtering of SNVs called from RNA-seq data using an SNP database, an obstacle that is difficult to overcome for most organisms.Here, we present a novel method named SPRINT that identifies RESs without the need to filter out SNPs. SPRINT also integrates the detection of hyper RESs from remapped reads, and has been fully automated to any RNA-seq data with reference genome sequence available. We have rigorously validated SPRINT's effectiveness in detecting RESs using RNA-seq data of samples in which genes encoding RNA editing enzymes are knock down or over-expressed, and have also demonstrated its superiority over current methods. We have applied SPRINT to investigate RNA editing across tissues and species, and also in the development of mouse embryonic central nervous system. A web resource ( http://sprint.tianlab.cn ) of RESs identified by SPRINT has been constructed.The software and related data are available at http://sprint.tianlab.cn .weidong.tian@fudan.edu.cn.Supplementary data are available at Bioinformatics online.",
        "keywords": "",
        "authors": [
            {
                "name": "Feng Zhang",
                "org": "State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development."
            },
            {
                "name": "Yulan Lu",
                "org": "The Molecular Genetic Diagnosis Center, Shanghai Key Lab of Birth Defect, Translational Medicine Research Center of Children Development and Diseases, Pediatrics Research Institute."
            },
            {
                "name": "Sijia Yan",
                "org": "Children's Hospital of Fudan University, Shanghai 201102, China."
            },
            {
                "name": "Qinghe Xing",
                "org": "Children's Hospital of Fudan University, Shanghai 201102, China."
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development."
            }
        ],
        "venue": "Bioinformatics",
        "year": 2017
    },
    "AOiDS5HF": {
        "id": "AOiDS5HF",
        "title": "Dynamic Editome of Zebrafish under Aminoglycosides Treatment and Its Potential Involvement in Ototoxicity.",
        "abstract": "RNA editing is an important co- and post-transcriptional event that generates RNA and protein diversity. Aminoglycosides are a group of bactericidal antibiotics and a mainstay of antimicrobial therapy for several life-threatening infections. However, aminoglycosides can induce ototoxicity, resulting in damage to the organs responsible for hearing and balance. At low concentrations, aminoglycosides can bind to many RNA sequences and critically influence RNA editing. We used a bioinformatics approach to investigate the effect of aminoglycosides on global mRNA editing events to gain insight into the interactions between mRNA editing and aminoglycoside ototoxicity. We identified 6,850 mRNA editing sites in protein coding genes in embryonic zebrafish, and in about 10% of these, the degree of RNA editing changed more than 15% under aminoglycosides treatment. Twelve ear-development or ototoxicity related genes, including plekhm1, fgfr1a, sox9a, and calrl2, exhibited remarkable changes in mRNA editing levels in zebrafish treated with aminoglycosides. Our results indicate that aminoglycosides may have a widespread and complicated influence on the progress of mRNA editing and expression. Furthermore, these results highlight the potential importance of mRNA editing in the pathogenesis and etiology of aminoglycoside-induced ototoxicity.",
        "keywords": [
            "RNA-Seq",
            "RNA-editing",
            "aminoglycosides (AG)",
            "ototoxicity",
            "zebrafish"
        ],
        "authors": [
            {
                "name": "Sijia Yan",
                "org": "Institutes of Biomedical Sciences and Children's Hospital, Fudan University, Shanghai, China."
            },
            {
                "name": "Yulan Lu",
                "org": "Children's Hospital, Fudan University, Shanghai, China."
            },
            {
                "name": "Lin He",
                "org": "Institutes of Biomedical Sciences and Children's Hospital, Fudan University, Shanghai, China."
            },
            {
                "name": "Xinzhi Zhao",
                "org": "Institutes of Biomedical Sciences and Children's Hospital, Fudan University, Shanghai, China."
            },
            {
                "name": "Lihua Wu",
                "org": "Zhengzhou People's Hospital, Zhengzhou, China."
            },
            {
                "name": "Huizhong Zhu",
                "org": "Institutes of Biomedical Sciences and Children's Hospital, Fudan University, Shanghai, China."
            },
            {
                "name": "Menglin Jiang",
                "org": "Institutes of Biomedical Sciences and Children's Hospital, Fudan University, Shanghai, China."
            },
            {
                "name": "Yu Su",
                "org": "Institutes of Biomedical Sciences and Children's Hospital, Fudan University, Shanghai, China."
            },
            {
                "name": "Wei Cao",
                "org": "Zhengzhou Central Hospital, Zhengzhou University, Zhengzhou, China."
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Biostatistics and Computational Biology, School of Life Science, Fudan University, Shanghai, China."
            },
            {
                "name": "Qinghe Xing",
                "org": "Institutes of Biomedical Sciences and Children's Hospital, Fudan University, Shanghai, China."
            }
        ],
        "venue": "Frontiers in pharmacology",
        "year": 2017
    },
    "nGDnIvns": {
        "id": "nGDnIvns",
        "title": "Evolution and Comprehensive Analysis of DNaseI Hypersensitive Sites in Regulatory Regions of Primate Brain-Related Genes.",
        "abstract": "How the human brain differs from those of non-human primates is largely unknown and the complex drivers underlying such differences at the genomic level remain unclear. In this study, we selected 243 brain-related genes, based on Gene Ontology, and identified 184,113 DNaseI hypersensitive sites (DHSs) within their regulatory regions. To performed comprehensive evolutionary analyses, we set strict filtering criteria for alignment quality and filtered 39,132 DHSs for inclusion in the investigation and found that 2,397 (~6%) exhibited evidence of accelerated evolution (aceDHSs), which was a much higher proportion that DHSs genome-wide. Target genes predicted to be regulated by brain-aceDHSs were functionally enriched for brain development and exhibited differential expression between human and chimpanzee. Alignments indicated 61 potential human-specific transcription factor binding sites in brain-aceDHSs, including for CTCF, FOXH1, and FOXQ1. Furthermore, based on GWAS, Hi-C, and eQTL data, 16 GWAS SNPs, and 82 eQTL SNPs were in brain-aceDHSs that regulate genes related to brain development or disease. Among these brain-aceDHSs, we confirmed that one enhanced the expression of GPR133, using CRISPR-Cas9 and western blotting. The  gene is associated with glioblastoma, indicating that SNPs within DHSs could be related to brain disorders. These findings suggest that brain-related gene regulatory regions are under adaptive evolution and contribute to the differential expression profiles among primates, providing new insights into the genetic basis of brain phenotypes or disorders between humans and other primates.",
        "keywords": [
            "DNaseI hypersensitive sites",
            "brain",
            "evolution",
            "primates",
            "regulatory region"
        ],
        "authors": [
            {
                "name": "Yueer Lu",
                "org": "School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China."
            },
            {
                "name": "Xiao Wang",
                "org": "State Key Laboratory of Genetic Engineering, Department of Biostatistics and Computational Biology, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China."
            },
            {
                "name": "Hang Yu",
                "org": "School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China."
            },
            {
                "name": "Jianlin Li",
                "org": "School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China."
            },
            {
                "name": "Zhiqiang Jiang",
                "org": "School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China."
            },
            {
                "name": "Bangwei Chen",
                "org": "School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China."
            },
            {
                "name": "Yueqi Lu",
                "org": "School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China."
            },
            {
                "name": "Wei Wang",
                "org": "School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China."
            },
            {
                "name": "Chongyin Han",
                "org": "School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China."
            },
            {
                "name": "Ying Ouyang",
                "org": "School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China."
            },
            {
                "name": "Lizhen Huang",
                "org": "School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China."
            },
            {
                "name": "Chunbo Chen",
                "org": "Department of Critical Care Medicine, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China."
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Genetic Engineering, Department of Biostatistics and Computational Biology, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China."
            },
            {
                "name": "Fei Ling",
                "org": "School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China."
            }
        ],
        "venue": "Frontiers in genetics",
        "year": 2019
    },
    "fYFK4Rp7": {
        "id": "fYFK4Rp7",
        "title": "Integration of Cancer Gene Co-expression Network and Metabolic Network To Uncover Potential Cancer Drug Targets",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weidong tian",
                "org": ""
            },
            {
                "name": "jianzhong jeff xi",
                "org": ""
            },
            {
                "name": "ning shen",
                "org": ""
            },
            {
                "name": "ming ma",
                "org": ""
            },
            {
                "name": "jingqi chen",
                "org": ""
            }
        ],
        "venue": "Journal of Proteome Research",
        "year": 2013
    },
    "I6AtDXGV": {
        "id": "I6AtDXGV",
        "title": "Whole genome sequencing identifies a novel ALMS1 gene mutation in two Chinese siblings with Alstr\u00f6m syndrome",
        "abstract": "We reported a novel ALMS1 mutation. Whole genome sequencing is a powerful tool to provide the full spectrum of genetic variations for heterogeneous disorders such as Alstr\u00f6m syndrome.",
        "keywords": [
            "ALMS1 gene",
            "Alstr\u00f6m syndrome",
            "Cone-rod dystrophy",
            "Whole genome sequencing"
        ],
        "authors": [
            {
                "name": "Lin Yang",
                "org": "Key Laboratory of Birth Defects, Children's Hospital of Fudan University, Shanghai, China."
            },
            {
                "name": "Zixiu Li",
                "org": "Department of Biostatistics and Computational Biology, Life Science, Fudan University, Shanghai, China."
            },
            {
                "name": "Mei Mei",
                "org": "Division of Respiration, Children's Hospital of Fudan University, Shanghai, China."
            },
            {
                "name": "Xiaomei Fan",
                "org": "BGI technology, Shanghai, China."
            },
            {
                "name": "Guodong Zhan",
                "org": "Department of Biostatistics and Computational Biology, Life Science, Fudan University, Shanghai, China."
            },
            {
                "name": "Huijun Wang",
                "org": "Key Laboratory of Birth Defects, Children's Hospital of Fudan University, Shanghai, China."
            },
            {
                "name": "Guoying Huang",
                "org": "Key Laboratory of Birth Defects, Children's Hospital of Fudan University, Shanghai, China."
            },
            {
                "name": "Mingbang Wang",
                "org": "BGI technology, Shanghai, China."
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Biostatistics and Computational Biology, Life Science, Fudan University, Shanghai, China."
            },
            {
                "name": "Wenhao Zhou",
                "org": "Department of Neonates, Children's Hospital, Fudan University, 399 Wan Yuan Road, Shanghai, China, 201102. zwhchfu@126.com."
            }
        ],
        "venue": "BMC medical genetics",
        "year": 2017
    },
    "yYkmoOJH": {
        "id": "yYkmoOJH",
        "title": "Virion protein 16 induces demethylation of DNA integrated within chromatin in a novel mammalian cell model.",
        "abstract": "DNA methylation and demethylation play important roles in mediating epigenetic regulation. So far, the mechanism of DNA demethylation remains elusive and controversial. Here, we constructed a plasmid, named with pCBS-luc, that contained an artificial CpG island, eight Gal4 DNA-binding domain binding site, an SV40 promoter, and a firefly luciferase reporter gene. The linearized pCBS-luc plasmid was methylated in vitro by DNA methyltransferase, and transfected into the HEK293 cells. The stable HEK293 transfectants with methylated pCBS-luc (me-pCBS-luc) were selected and obtained. The methylation status of the selected stable cell lines were confirmed by bisulfite sequencing polymerase chain reaction amplification. The methylation status could be maintained even after 15 passages. The virion protein 16 (VP16) was reported to enhance DNA demethylation around its binding sites of the promoter region in Xenopus fertilized eggs. Using our me-pCBS-luc model, we found that VP16 also had the ability to activate the expression of methylated luciferase reporter gene and induce DNA demethylation in chromatin DNA in mammalian cells. Altogether, we constructed a cell model stably integrated with the me-pCBS-luc reporter plasmid, and in this model we found that VP16 could lead to DNA demethylation. We believe that this cell model will have many potential applications in the future research on DNA demethylation and dynamic process of chromatin modification.",
        "keywords": [],
        "authors": [
            {
                "name": "Lu Yang",
                "org": "Key Laboratory of Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, China."
            },
            {
                "name": "Huijun Wang",
                "org": ""
            },
            {
                "name": "Xin Luo",
                "org": ""
            },
            {
                "name": "Pengliang Mao",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Yujiang Shi",
                "org": ""
            },
            {
                "name": "Guoying Huang",
                "org": ""
            },
            {
                "name": "Jin Zhang",
                "org": ""
            },
            {
                "name": "Duan Ma",
                "org": ""
            }
        ],
        "venue": "Acta biochimica et biophysica Sinica",
        "year": 2012
    },
    "7dMWkJfU": {
        "id": "7dMWkJfU",
        "title": "Prediction of Metabolic Gene Biomarkers for Neurodegenerative Disease by an Integrated Network-Based Approach",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "qi ni",
                "org": ""
            },
            {
                "name": "xianming su",
                "org": ""
            },
            {
                "name": "jingqi chen",
                "org": ""
            },
            {
                "name": "weidong tian",
                "org": ""
            }
        ],
        "venue": "BioMed Research International",
        "year": 2015
    },
    "fMC4q7A6": {
        "id": "fMC4q7A6",
        "title": "Genome-Wide Identification of Regulatory Sequences Undergoing Accelerated Evolution in the Human Genome",
        "abstract": "Accelerated evolution of regulatory sequence can alter the expression pattern of target genes, and cause phenotypic changes. In this study, we used DNase I hypersensitive sites (DHSs) to annotate putative regulatory sequences in the human genome, and conducted a genome-wide analysis of the effects of accelerated evolution on regulatory sequences. Working under the assumption that local ancient repeat elements of DHSs are under neutral evolution, we discovered that \u223c0.44% of DHSs are under accelerated evolution (ace-DHSs). We found that ace-DHSs tend to be more active than background DHSs, and are strongly associated with epigenetic marks of active transcription. The target genes of ace-DHSs are significantly enriched in neuron-related functions, and their expression levels are positively selected in the human brain. Thus, these lines of evidences strongly suggest that accelerated evolution on regulatory sequences plays important role in the evolution of human-specific phenotypes.",
        "keywords": "",
        "authors": [
            {
                "name": "Xinran Dong",
                "org": "1State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University, Shanghai, P.R. China"
            },
            {
                "name": "Xiao Wang",
                "org": "1State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University, Shanghai, P.R. China"
            },
            {
                "name": "Feng Zhang",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": "1State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University, Shanghai, P.R. China"
            }
        ],
        "venue": "Molecular Biology and Evolution",
        "year": 2016
    },
    "pqDBFdRB": {
        "id": "pqDBFdRB",
        "title": "An iterative network partition algorithm for accurate identification of",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "siqi sun",
                "org": ""
            },
            {
                "name": "x dong",
                "org": ""
            },
            {
                "name": "yao fu",
                "org": ""
            },
            {
                "name": "weidong tian",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2010
    },
    "FzRnHrw0": {
        "id": "FzRnHrw0",
        "title": "Cai et al. Microbial Cell Factories 2011, 10:88",
        "abstract": "",
        "keywords": [
            "polyhydroxyalkanoates",
            "genome",
            "osmolytes"
        ],
        "authors": [
            {
                "name": "lei cai",
                "org": ""
            },
            {
                "name": "d tan",
                "org": ""
            },
            {
                "name": "gulsimay aibaidula",
                "org": ""
            },
            {
                "name": "x dong",
                "org": ""
            },
            {
                "name": "jinchun chen",
                "org": ""
            },
            {
                "name": "weidong tian",
                "org": ""
            },
            {
                "name": "guoqiang chen",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "QCfa0Fri": {
        "id": "QCfa0Fri",
        "title": "acquisition and fixation of drug resistance in patients",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "gang sun",
                "org": ""
            },
            {
                "name": "tao luo",
                "org": ""
            },
            {
                "name": "chongguang yang",
                "org": ""
            },
            {
                "name": "x dong",
                "org": ""
            },
            {
                "name": "jing li",
                "org": ""
            },
            {
                "name": "huajun zheng",
                "org": ""
            },
            {
                "name": "weidong tian",
                "org": ""
            },
            {
                "name": "shengyue wang",
                "org": ""
            },
            {
                "name": "clifton e barry",
                "org": ""
            },
            {
                "name": "qian gao",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2012
    },
    "0YKCSQXZ": {
        "id": "0YKCSQXZ",
        "title": "Identification of novel candidate maternal serum protein markers for Down syndrome by integrated proteomic and bioinformatic analysis: Identification of novel candidate maternal serum protein markers for Down syndrome",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weidong tian",
                "org": ""
            },
            {
                "name": "yan cheng",
                "org": ""
            },
            {
                "name": "yuan kang",
                "org": ""
            },
            {
                "name": "duan ma",
                "org": ""
            },
            {
                "name": "xiaohui liu",
                "org": ""
            },
            {
                "name": "hong jin",
                "org": ""
            },
            {
                "name": "xiaotian li",
                "org": ""
            },
            {
                "name": "cuihong su",
                "org": ""
            },
            {
                "name": "rong hu",
                "org": ""
            },
            {
                "name": "ying zhang",
                "org": ""
            },
            {
                "name": "qiongjie zhou",
                "org": ""
            },
            {
                "name": "x dong",
                "org": ""
            }
        ],
        "venue": "Prenatal Diagnosis",
        "year": 2012
    },
    "zAvB9Q6e": {
        "id": "zAvB9Q6e",
        "title": "GenePANDA\u2014a novel network-based gene prioritizing tool for complex diseases",
        "abstract": "A Nature Research Journal",
        "keywords": "",
        "authors": [
            {
                "name": "Tianshu Yin",
                "org": "State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200436, P. R. China"
            },
            {
                "name": "Shu Chen",
                "org": "State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200436, P. R. China"
            },
            {
                "name": "Xiaohui Wu",
                "org": "State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200436, P. R. China"
            },
            {
                "name": "Weidong Tian",
                "org": "State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200436, P. R. China"
            },
            {
                "name": "Tianshu Yin",
                "org": "Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University, Shanghai 200436, P. R. China"
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University, Shanghai 200436, P. R. China"
            },
            {
                "name": "Shu Chen",
                "org": "National Center for International Research of Development and Disease, Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200433, P. R. China"
            },
            {
                "name": "Xiaohui Wu",
                "org": "National Center for International Research of Development and Disease, Institute of Developmental Biology and Molecular Medicine, Fudan University, Shanghai 200433, P. R. China"
            }
        ],
        "venue": "Scientific Reports",
        "year": 2017
    },
    "StfX2gzi": {
        "id": "StfX2gzi",
        "title": "Prediction of Candidate Drugs for Treating Pancreatic Cancer by Using a Combined Approach.",
        "abstract": "Pancreatic cancer is the leading cause of death from solid malignancies worldwide. Currently, gemcitabine is the only drug approved for treating pancreatic cancer. Developing new therapeutic drugs for this disease is, therefore, an urgent need. The C-Map project has provided a wealth of gene expression data that can be mined for repositioning drugs, a promising approach to new drug discovery. Typically, a drug is considered potentially useful for treating a disease if the drug-induced differential gene expression profile is negatively correlated with the differentially expressed genes in the target disease. However, many of the potentially useful drugs (PUDs) identified by gene expression profile correlation are likely false positives because, in C-Map, the cultured cell lines to which the drug is applied are not derived from diseased tissues. To solve this problem, we developed a combined approach for predicting candidate drugs for treating pancreatic cancer. We first identified PUDs for pancreatic cancer by using C-Map-based gene expression correlation analyses. We then applied an algorithm (Met-express) to predict key pancreatic cancer (KPC) enzymes involved in pancreatic cancer metabolism. Finally, we selected candidates from the PUDs by requiring that their targets be KPC enzymes or the substrates/products of KPC enzymes. Using this combined approach, we predicted seven candidate drugs for treating pancreatic cancer, three of which are supported by literature evidence, and three were experimentally validated to be inhibitory to pancreatic cancer celllines.",
        "keywords": "",
        "authors": [
            {
                "name": "Yanfen Ma",
                "org": "Department of Clinical Laboratory, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, Shaanxi province, P.R. China"
            },
            {
                "name": "Jian Hu",
                "org": "Department of Clinical Laboratory, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, Shaanxi province, P.R. China"
            },
            {
                "name": "Ning Zhang",
                "org": "Department of Clinical Laboratory, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, Shaanxi province, P.R. China"
            },
            {
                "name": "Xinran Dong",
                "org": "Department of Biostatistics and Computational Biology, School of Life Science, Fudan University, Shanghai, China"
            },
            {
                "name": "Ying Li",
                "org": "Health Science Center of Xi\u2019an Jiaotong University, Xi'an, Shaanxi province, P.R. China"
            },
            {
                "name": "Bo Yang",
                "org": "Department of Clinical Laboratory, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, Shaanxi province, P.R. China"
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Biostatistics and Computational Biology, School of Life Science, Fudan University, Shanghai, China"
            },
            {
                "name": "Xiaoqin Wang",
                "org": "Department of Clinical Laboratory, The First Affiliated Hospital of Xi\u2019an Jiaotong University, Xi'an, Shaanxi province, P.R. China"
            }
        ],
        "venue": "PLOS ONE",
        "year": 2016
    },
    "zv3aKdPN": {
        "id": "zv3aKdPN",
        "title": "Solute Carrier Family 26 Member a2 (slc26a2) Regulates Otic Development and Hair Cell Survival in Zebrafish",
        "abstract": "Hearing loss is one of the most prevalent human birth defects. Genetic factors contribute to the pathogenesis of deafness. It is estimated that one-third of deafness genes have already been identified. The current work is an attempt to find novel genes relevant to hearing loss using guilt-by-profiling and guilt-by-association bioinformatics analyses of approximately 80 known non-syndromic hereditary hearing loss (NSHL) genes. Among the 300 newly identified candidate deafness genes, slc26a2 were selected for functional studies in zebrafish. The slc26a2 gene was knocked down using an antisense morpholino (MO), and significant defects were observed in otolith patterns, semicircular canal morphology, and lateral neuromast distributions in morphants. Loss-of-function defects are caused primarily by apoptosis, and morphants are insensitive to sound stimulation and imbalanced swimming behaviours. Morphant defects were found to be partially rescued by co-injection of human SLC26A2 mRNA. All the results suggest that bioinformatics is capable of predicting new deafness genes and this showed slc26a2 is to be a critical otic gene whose dysfunction may induce hearing impairment.",
        "keywords": "",
        "authors": [
            {
                "name": "Fei Liu",
                "org": "Fudan University"
            },
            {
                "name": "Wenjun Xia",
                "org": "Institutes of Biomedical Science, Fudan University, Shanghai, 200032, China"
            },
            {
                "name": "Jiongjiong Hu",
                "org": "Department of Otorhinolaryngology, Shanghai East Hospital, Tongji University, Shanghai, China"
            },
            {
                "name": "Y.S. Wang",
                "org": ""
            },
            {
                "name": "Fan Yang",
                "org": "Institutes of Biomedical Science, Fudan University, Shanghai, 200032, China"
            },
            {
                "name": "Shaoyang Sun",
                "org": "Fudan University"
            },
            {
                "name": "Jin Zhang",
                "org": "Fudan University"
            },
            {
                "name": "Nan Jiang",
                "org": "Fudan University"
            },
            {
                "name": "Huijun Wang",
                "org": "Children\u2019s Hospital, Fudan University, Shanghai, 200032, China"
            },
            {
                "name": "Weidong Tian",
                "org": "School of Life Sciences, Institute of Biostatistics, Fudan University, Shanghai, P.R. China"
            },
            {
                "name": "Xu Wang",
                "org": ""
            },
            {
                "name": "Duan Ma",
                "org": "Fudan University"
            }
        ],
        "venue": "PLOS ONE",
        "year": 2015
    },
    "45KCYFzI": {
        "id": "45KCYFzI",
        "title": "An en masse phenotype and function prediction system for Mus musculus.",
        "abstract": "Background:\u00a0\u00a0Individual researchers are struggling to keep up with the accelerating emergence of high-throughput biological data, and to\n extract information that relates to their specific questions. Integration of accumulated evidence should permit researchers\n to form fewer - and more accurate - hypotheses for further study through experimentation.\n \n \n \n \n Results:\u00a0\u00a0Here a method previously used to predict Gene Ontology (GO) terms for Saccharomyces cerevisiae (Tian et al.: Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 2008, 9(Suppl 1):S7) is applied to predict GO terms and phenotypes for 21,603 Mus musculus genes, using a diverse collection of integrated data sources (including expression, interaction, and sequence-based data).\n This combined 'guilt-by-profiling' and 'guilt-by-association' approach optimizes the combination of two inference methodologies.\n Predictions at all levels of confidence are evaluated by examining genes not used in training, and top predictions are examined\n manually using available literature and knowledge base resources.\n \n \n \n \n Conclusion:\u00a0\u00a0We assigned a confidence score to each gene/term combination. The results provided high prediction performance, with nearly\n every GO term achieving greater than 40% precision at 1% recall. Among the 36 novel predictions for GO terms and 40 for phenotypes\n that were studied manually, >80% and >40%, respectively, were identified as accurate. We also illustrate that a combination\n of 'guilt-by-profiling' and 'guilt-by-association' outperforms either approach alone in their application to M. musculus.",
        "keywords": [
            "knowledge base",
            "algorithms",
            "proteins",
            "high throughput",
            "artificial intelligence",
            "biological data"
        ],
        "authors": [
            {
                "name": "Murat Ta\u015fan",
                "org": "Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Avenue, Boston, Massachusetts 02115, USA."
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Biological Chemistry and Molecular Pharmacology,Harvard Medical School,Boston,USA"
            },
            {
                "name": "David P Hill",
                "org": "Computational Biology and Bioinformatics,The Jackson Laboratory,Bar Harbor,USA"
            },
            {
                "name": "Francis D Gibbons",
                "org": "Merrimack Pharmaceuticals,Cambridge,USA"
            },
            {
                "name": "Judith A Blake",
                "org": "Computational Biology and Bioinformatics,The Jackson Laboratory,Bar Harbor,USA"
            },
            {
                "name": "Frederick P Roth",
                "org": "Department of Biological Chemistry and Molecular Pharmacology,Harvard Medical School,Boston,USA"
            }
        ],
        "venue": "Genome biology",
        "year": 2008
    },
    "oeiFSaak": {
        "id": "oeiFSaak",
        "title": "A critical assessment of Mus musculus gene function prediction using integrated genomic evidence.",
        "abstract": "Several years after sequencing the human genome and the mouse genome, much remains to be discovered about the functions of most human and mouse genes. Computational prediction of gene function promises to help focus limited experimental resources on the most likely hypotheses. Several algorithms using diverse genomic data have been applied to this task in model organisms; however, the performance of such approaches in mammals has not yet been evaluated.In this study, a standardized collection of mouse functional genomic data was assembled; nine bioinformatics teams used this data set to independently train classifiers and generate predictions of function, as defined by Gene Ontology (GO) terms, for 21,603 mouse genes; and the best performing submissions were combined in a single set of predictions. We identified strengths and weaknesses of current functional genomic data sets and compared the performance of function prediction algorithms. This analysis inferred functions for 76% of mouse genes, including 5,000 currently uncharacterized genes. At a recall rate of 20%, a unified set of predictions averaged 41% precision, with 26% of GO terms achieving a precision better than 90%.We performed a systematic evaluation of diverse, independently developed computational approaches for predicting gene function from heterogeneous data sources in mammals. The results show that currently available data for mammals allows predictions with both breadth and accuracy. Importantly, many highly novel predictions emerge for the 38% of mouse genes that remain uncharacterized.",
        "keywords": [
            "algorithms",
            "proteins",
            "functional genomics",
            "human genome"
        ],
        "authors": [
            {
                "name": "Lourdes Pe\u00f1a-Castillo",
                "org": "Donnelly Centre for Cellular and Biomolecular Research|University of Toronto"
            },
            {
                "name": "Murat Tasan",
                "org": "Department of Biological Chemistry and Molecular Pharmacology|Harvard Medical School"
            },
            {
                "name": "Chad L Myers",
                "org": "Lewis-Sigler Institute for Integrative Genomics and Department of Molecular Biology|Princeton University|Department of Information and Communications|Gwangju Institute of Science and Technology"
            },
            {
                "name": "Hyunju Lee",
                "org": "Department of Information and Communications, Gwangju Institute of Science and Technology, Gwangju, 500-712 Republic of Korea"
            },
            {
                "name": "Trupti Joshi",
                "org": "Digital Biology Laboratory|Computer Science Department|Christopher S. Bond Life Sciences Center|University of Missouri"
            },
            {
                "name": "Chao Zhang",
                "org": "Digital Biology Laboratory|Computer Science Department|Christopher S. Bond Life Sciences Center|University of Missouri"
            },
            {
                "name": "Yuanfang Guan",
                "org": "Lewis-Sigler Institute for Integrative Genomics and Department of Molecular Biology|Princeton University|Department of Information and Communications|Gwangju Institute of Science and Technology"
            },
            {
                "name": "Michele Leone",
                "org": "ISI Foundation"
            },
            {
                "name": "Andrea Pagnani",
                "org": "ISI Foundation, Torino, 10133, Italy"
            },
            {
                "name": "Wan Kyu Kim",
                "org": "Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA"
            },
            {
                "name": "Chase Krumpelman",
                "org": "Department of Electrical and Computer Engineering, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA"
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA"
            },
            {
                "name": "Guillaume Obozinski",
                "org": "Department of Statistics, UC Berkeley, Berkeley, CA 94720-3860, USA"
            },
            {
                "name": "Yanjun Qi",
                "org": "School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA"
            },
            {
                "name": "Sara Mostafavi",
                "org": "Department of Computer Science, University of Toronto, Toronto, ON M5S3G4, Canada"
            },
            {
                "name": "Guan Ning Lin",
                "org": "Digital Biology Laboratory, Computer Science Department and Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA"
            },
            {
                "name": "Gabriel F Berriz",
                "org": "Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA"
            },
            {
                "name": "Francis D Gibbons",
                "org": "Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA"
            },
            {
                "name": "Gert Lanckriet",
                "org": "Department of Electrical and Computer Engineering, UC San Diego, La Jolla, CA 92093-0407, USA"
            },
            {
                "name": "Jian Qiu",
                "org": "Department of Genome Sciences, University of Washington, Seattle, WA 98195-5065, USA"
            },
            {
                "name": "Charles Grant",
                "org": "Department of Genome Sciences, University of Washington, Seattle, WA 98195-5065, USA"
            },
            {
                "name": "Zafer Barutcuoglu",
                "org": "Department of Computer Science, Princeton University, Princeton, NJ 08544, USA"
            },
            {
                "name": "David P Hill",
                "org": "Bioinformatics and Computational Biology, The Jackson Laboratory, Bar Harbor, ME 04609, USA"
            },
            {
                "name": "David Warde-Farley",
                "org": "Department of Computer Science, University of Toronto, Toronto, ON M5S3G4, Canada"
            },
            {
                "name": "Chris Grouios",
                "org": "Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S3E1, Canada"
            },
            {
                "name": "Debajyoti Ray",
                "org": "Gatsby Computational Neuroscience Unit, London, WC1N 3AR, UK"
            },
            {
                "name": "Judith A Blake",
                "org": "Bioinformatics and Computational Biology, The Jackson Laboratory, Bar Harbor, ME 04609, USA"
            },
            {
                "name": "Minghua Deng",
                "org": "School of Mathematical Sciences and Center for Theoretical Biology, Peking University, Beijing 100871, PRC"
            },
            {
                "name": "Michael I Jordan",
                "org": "Department of Electrical Engineering and Computer Science, and Department of Statistics, UC Berkeley, Berkeley, CA 94720-1776, USA"
            },
            {
                "name": "William S Noble",
                "org": "Department of Genome Sciences, and Department of Computer Science and Engineering, University of Washington, Seattle, WA 98195, USA"
            },
            {
                "name": "Quaid Morris",
                "org": "Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S3E1, Canada|Department of Computer Science, University of Toronto, Toronto, ON M5S3G4, Canada|Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5S 3E1, Canada"
            },
            {
                "name": "Judith Klein-Seetharaman",
                "org": "Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA"
            },
            {
                "name": "Ziv Bar-Joseph",
                "org": "School of Computer Science, Carnegie Mellon University, Pittsburgh, PA 15213, USA"
            },
            {
                "name": "Ting Chen",
                "org": "Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA"
            },
            {
                "name": "Fengzhu Sun",
                "org": "Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA"
            },
            {
                "name": "Olga G Troyanskaya",
                "org": "Lewis-Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA"
            },
            {
                "name": "Edward M Marcotte",
                "org": "Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA"
            },
            {
                "name": "Dong Xu",
                "org": "Digital Biology Laboratory, Computer Science Department and Christopher S Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA"
            },
            {
                "name": "Timothy R Hughes",
                "org": "Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S3E1, Canada|Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5S 3E1, Canada"
            },
            {
                "name": "Frederick P Roth",
                "org": "Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA|Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA"
            }
        ],
        "venue": "Genome biology",
        "year": 2008
    },
    "t2gzTKfK": {
        "id": "t2gzTKfK",
        "title": "Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function.",
        "abstract": "Learning the function of genes is a major goal of computational genomics. Methods for inferring gene function have typically fallen into two categories: 'guilt-by-profiling', which exploits correlation between function and other gene characteristics; and 'guilt-by-association', which transfers function from one gene to another via biological relationships.We have developed a strategy ('Funckenstein') that performs guilt-by-profiling and guilt-by-association and combines the results. Using a benchmark set of functional categories and input data for protein-coding genes in Saccharomyces cerevisiae, Funckenstein was compared with a previous combined strategy. Subsequently, we applied Funckenstein to 2,455 Gene Ontology terms. In the process, we developed 2,455 guilt-by-profiling classifiers based on 8,848 gene characteristics and 12 functional linkage graphs based on 23 biological relationships.Funckenstein outperforms a previous combined strategy using a common benchmark dataset. The combination of 'guilt-by-profiling' and 'guilt-by-association' gave significant improvement over the component classifiers, showing the greatest synergy for the most specific functions. Performance was evaluated by cross-validation and by literature examination of the top-scoring novel predictions. These quantitative predictions should help prioritize experimental study of yeast gene functions.",
        "keywords": [
            "transfer function",
            "computational biology",
            "algorithms",
            "cross validation"
        ],
        "authors": [
            {
                "name": "Weidong Tian",
                "org": "Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Avenue, Boston, Massachusetts 02115, USA"
            },
            {
                "name": "Lan V Zhang",
                "org": "Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Avenue, Boston, Massachusetts 02115, USA|McKinsey and Company, Hansen Way, Palo Alto, California 94304, USA"
            },
            {
                "name": "Murat Ta\u015fan",
                "org": "Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Avenue, Boston, Massachusetts 02115, USA"
            },
            {
                "name": "Francis D Gibbons",
                "org": "Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Avenue, Boston, Massachusetts 02115, USA|Merrimack Pharmaceuticals, Kendall Square, Cambridge, Massachusetts 02139, USA"
            },
            {
                "name": "Oliver D King",
                "org": "Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Avenue, Boston, Massachusetts 02115, USA|Boston Biomedical Research Institute (BBRI), Grove St., Watertown, Massachusetts 02472, USA"
            },
            {
                "name": "Julie Park",
                "org": "Department of Genetics, School of Medicine, Stanford University, Stanford, California 94305-5120, USA"
            },
            {
                "name": "Zeba Wunderlich",
                "org": "Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Avenue, Boston, Massachusetts 02115, USA|Massachusetts Institute of Technology, Massachusetts Ave, Cambridge, Massachusetts 02139, USA"
            },
            {
                "name": "J Michael Cherry",
                "org": "Department of Genetics, School of Medicine, Stanford University, Stanford, California 94305-5120, USA"
            },
            {
                "name": "Frederick P Roth",
                "org": "Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Avenue, Boston, Massachusetts 02115, USA|Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Jimmy Fund Way, Boston, Massachusetts 02115, USA"
            }
        ],
        "venue": "Genome biology",
        "year": 2008
    },
    "QyOo84As": {
        "id": "QyOo84As",
        "title": "EFICAz: a comprehensive approach for accurate genome-scale enzyme function inference.",
        "abstract": "EFICAz (Enzyme Function Inference by Combined Approach) is an automatic engine for large-scale enzyme function inference that combines predictions from four different methods developed and optimized to achieve high prediction accuracy: (i) recognition of functionally discriminating residues (FDRs) in enzyme families obtained by a Conservation-controlled HMM Iterative procedure for Enzyme Family classification (CHIEFc), (ii) pairwise sequence comparison using a family specific Sequence Identity Threshold, (iii) recognition of FDRs in Multiple Pfam enzyme families, and (iv) recognition of multiple Prosite patterns of high specificity. For FDR (i.e. conserved positions in an enzyme family that discriminate between true and false members of the family) identification, we have developed an Evolutionary Footprinting method that uses evolutionary information from homofunctional and heterofunctional multiple sequence alignments associated with an enzyme family. The FDRs show a significant correlation with annotated active site residues. In a jackknife test, EFICAz shows high accuracy (92%) and sensitivity (82%) for predicting four EC digits in testing sequences that are <40% identical to any member of the corresponding training set. Applied to Escherichia coli genome, EFICAz assigns more detailed enzymatic function than KEGG, and generates numerous novel predictions.",
        "keywords": [
            "sequence alignment",
            "active site",
            "binding sites",
            "enzyme",
            "genomics",
            "escherichia coli",
            "amino acid sequence",
            "computational biology",
            "enzymes"
        ],
        "authors": [
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Adrian K Arakaki",
                "org": ""
            },
            {
                "name": "Jeffrey Skolnick",
                "org": ""
            }
        ],
        "venue": "Nucleic acids research",
        "year": 2004
    },
    "l0HRFblJ": {
        "id": "l0HRFblJ",
        "title": "How well is enzyme function conserved as a function of pairwise sequence identity?",
        "abstract": "Enzyme function conservation has been used to derive the threshold of sequence identity necessary to transfer function from a protein of known function to an unknown protein. Using pairwise sequence comparison, several studies suggested that when the sequence identity is above 40%, enzyme function is well conserved. In contrast, Rost argued that because of database bias, the results from such simple pairwise comparisons might be misleading. Thus, by grouping enzyme sequences into families based on sequence similarity and selecting representative sequences for comparison, he showed that enzyme function starts to diverge quickly when the sequence identity is below 70%. Here, we employ a strategy similar to Rost's to reduce the database bias; however, we classify enzyme families based not only on sequence similarity, but also on functional similarity, i.e. sequences in each family must have the same four digits or the same first three digits of the enzyme commission (EC) number. Furthermore, instead of selecting representative sequences for comparison, we calculate the function conservation of each enzyme family and then average the degree of enzyme function conservation across all enzyme families. Our analysis suggests that for functional transferability, 40% sequence identity can still be used as a confident threshold to transfer the first three digits of an EC number; however, to transfer all four digits of an EC number, above 60% sequence identity is needed to have at least 90% accuracy. Moreover, when PSI-BLAST is used, the magnitude of the E-value is found to be weakly correlated with the extent of enzyme function conservation in the third iteration of PSI-BLAST. As a result, functional annotation based on the E-values from PSI-BLAST should be used with caution. We also show that by employing an enzyme family-specific sequence identity threshold above which 100% functional conservation is required, functional inference of unknown sequences can be accurately accomplished. However, this comes at a cost: those true positive sequences below this threshold cannot be uniquely identified.",
        "keywords": [
            "ec",
            "psi-blast",
            "sequence comparisons",
            "enzyme commission",
            "conservation of protein function",
            "enzyme classification",
            "genome annotation",
            "transfer function",
            "enzyme"
        ],
        "authors": [
            {
                "name": "Weidong Tian",
                "org": "Department of Biology, Washington University in St Louis, One Brookings Drive, St Louis, MO 63130, USA"
            },
            {
                "name": "Jeffrey Skolnick",
                "org": ""
            }
        ],
        "venue": "Journal of molecular biology",
        "year": 2003
    },
    "vIkaX3V0": {
        "id": "vIkaX3V0",
        "title": "High precision multi-genome scale reannotation of enzyme function by EFICAz",
        "abstract": "BACKGROUND: The functional annotation of most genes in newly sequenced genomes is inferred from similarity to previously characterized sequences, an annotation strategy that often leads to erroneous assignments. We have performed a reannotation of 245 genomes using an updated version of EFICAz, a highly precise method for enzyme function prediction. RESULTS: Based on our three-field EC number predictions, we have obtained lower-bound estimates for the average enzyme content in Archaea (29%), Bacteria (30%) and Eukarya (18%). Most annotations added in KEGG from 2005 to 2006 agree with EFICAz predictions made in 2005. The coverage of EFICAz predictions is significantly higher than that of KEGG, especially for eukaryotes. Thousands of our novel predictions correspond to hypothetical proteins. We have identified a subset of 64 hypothetical proteins with low sequence identity to EFICAz training enzymes, whose biochemical functions have been recently characterized and find that in 96% (84%) of the cases we correctly identified their three-field (four-field) EC numbers. For two of the 64 hypothetical proteins: PA1167 from Pseudomonas aeruginosa, an alginate lyase (EC 4.2.2.3) and Rv1700 of Mycobacterium tuberculosis H37Rv, an ADP-ribose diphosphatase (EC 3.6.1.13), we have detected annotation lag of more than two years in databases. Two examples are presented where EFICAz predictions act as hypothesis generators for understanding the functional roles of hypothetical proteins: FLJ11151, a human protein overexpressed in cancer that EFICAz identifies as an endopolyphosphatase (EC 3.6.1.10), and MW0119, a protein of Staphylococcus aureus strain MW2 that we propose as candidate virulence factor based on its EFICAz predicted activity, sphingomyelin phosphodiesterase (EC 3.1.4.12). CONCLUSION: Our results suggest that we have generated enzyme function annotations of high precision and recall. These predictions can be mined and correlated with other information sources to generate biologically significant hypotheses and can be useful for comparative genome analysis and automated metabolic pathway reconstruction.",
        "keywords": [
            "genome",
            "proteomics",
            "metabolic pathway",
            "enzyme",
            "archaea",
            "genomics",
            "phosphodiesterase",
            "bacteria",
            "microarrays",
            "lower bound",
            "enzymes",
            "comparative genomics"
        ],
        "authors": [
            {
                "name": "Adrian K Arakaki",
                "org": "Center for the Study of Systems Biology, School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30318, USA"
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusett 02115, USA"
            },
            {
                "name": "Jeffrey Skolnick",
                "org": "Center for the Study of Systems Biology, School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30318, USA"
            }
        ],
        "venue": "BMC Genomics",
        "year": 2006
    },
    "qsU9qxGP": {
        "id": "qsU9qxGP",
        "title": "FuncBase",
        "abstract": "Summary: Computational gene function prediction can serve to focus experimental resources on high-priority experimental tasks. FuncBase is a web resource for viewing quantitative machine learning-based gene function annotations. Quantitative annotations of genes, including fungal and mammalian genes, with Gene Ontology terms are accompanied by a community feedback system. Evidence underlying function annotations is shown. For example, a custom Cytoscape viewer shows functional linkage graphs relevant to the gene or function of interest. FuncBase provides links to external resources, and may be accessed directly or via links from species-specific databases. Availability: FuncBase as well as all underlying data and annotations are freely available via http://func.med.harvard.edu/ Contact: fritz_roth@hms.harvard.edu",
        "keywords": [
            "quantitative annotation",
            "learning-based gene function annotation",
            "computational gene function prediction",
            "experimental resource",
            "mammalian gene",
            "function annotation",
            "Gene Ontology term",
            "underlying data",
            "quantitative machine",
            "high-priority experimental task"
        ],
        "authors": [
            {
                "name": "John E. Beaver",
                "org": ""
            },
            {
                "name": "Murat Ta\u015fan",
                "org": ""
            },
            {
                "name": "Francis D. Gibbons",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Timothy R. Hughes",
                "org": ""
            },
            {
                "name": "Frederick P. Roth",
                "org": ""
            }
        ],
        "venue": "Bioinformatics",
        "year": 2010
    },
    "TC4JTKsd": {
        "id": "TC4JTKsd",
        "title": "FuncBase: a resource for quantitative gene function annotation.",
        "abstract": "Computational gene function prediction can serve to focus experimental resources on high-priority experimental tasks. FuncBase is a web resource for viewing quantitative machine learning-based gene function annotations. Quantitative annotations of genes, including fungal and mammalian genes, with Gene Ontology terms are accompanied by a community feedback system. Evidence underlying function annotations is shown. For example, a custom Cytoscape viewer shows functional linkage graphs relevant to the gene or function of interest. FuncBase provides links to external resources, and may be accessed directly or via links from species-specific databases.FuncBase as well as all underlying data and annotations are freely available via http://func.med.harvard.edu/",
        "keywords": [],
        "authors": [
            {
                "name": "John E Beaver",
                "org": ""
            },
            {
                "name": "Murat Tasan",
                "org": ""
            },
            {
                "name": "Francis D Gibbons",
                "org": ""
            },
            {
                "name": "Weidong Tian",
                "org": ""
            },
            {
                "name": "Timothy R Hughes",
                "org": ""
            },
            {
                "name": "Frederick P Roth",
                "org": ""
            }
        ],
        "venue": "Bioinformatics",
        "year": 2010
    },
    "pPxs5ckp": {
        "id": "pPxs5ckp",
        "title": "Light responsive curve selection for photosynthesis operator of APOA",
        "abstract": "Artificial plant optimisation algorithm (APOA) is a recent proposed evolutionary computation methodology in which the growing process of one tree is mapped into the optimised problem. In APOA, three new operators: photosynthesis operator, phototropism operator and apical dominance operator are designed to simulate three important phenomenon. In the standard version of APOA, the light responsive curve of photosynthesis operator is selected as rectangular hyperbolic model which is only a general one. However, we argue whether the rectangular hyperbolic model provide the best average performance? In this paper, seven classical models are chosen to investigate, they are: rectangular hyperbolic model, non-rectangular hyperbolic model, updated rectangular hyperbolic model, parabola model, straight line model and two exponential curve models. To test the performance, eleven benchmarks are selected. In each experiment, the light responsive curve is translated by the corresponding model. Simulation results show the average performance of parabola model is best when compared with other six models.",
        "keywords": [
            "classical model",
            "updated rectangular hyperbolic model",
            "light responsive curve selection",
            "exponential curve model",
            "non-rectangular hyperbolic model",
            "corresponding model",
            "rectangular hyperbolic model",
            "average performance",
            "parabola model",
            "photosynthesis operator",
            "straight line model"
        ],
        "authors": [
            {
                "name": "Xingjuan Cai",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, 030024, China"
            },
            {
                "name": "Shujing Fan",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, 030024, China"
            },
            {
                "name": "Ying Tan",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, 030024, China"
            }
        ],
        "venue": "IJBIC",
        "year": 2012
    },
    "H71TyVYi": {
        "id": "H71TyVYi",
        "title": "Multi-objective Infill Criterion Driven Gaussian Process Assisted Particle Swarm Optimization of High-dimensional Expensive Problems",
        "abstract": "Model management plays an essential role in surrogate-assisted evolutionary optimization of expensive problems, since the strategy for selecting individuals for fitness evaluation using the real objective function has substantial influences on the final performance. Among many others, infill criterion driven Gaussian process (GP)-assisted evolutionary algorithms have been demonstrated competitive for optimization of problems with up to 50 decision variables. In this paper, a multiobjective infill criterion (MIC) that considers the approximated fitness and the approximation uncertainty as two objectives is proposed for a GP-assisted social learning particle swarm optimization algorithm. The MIC uses nondominated sorting for model management, thereby avoiding combining the approximated fitness and the approximation uncertainty into a scalar function, which is shown to be particularly important for high-dimensional problems, where the estimated uncertainty becomes less reliable. Empirical studies on 50-D and 100-D benchmark problems and a synthetic problem constructed from four real-world optimization problems demonstrate that the proposed MIC is more effective than existing scalar infill criteria for GP-assisted optimization given a limited computational budget.",
        "keywords": [
            "Optimization",
            "Uncertainty",
            "Gaussian processes",
            "Linear programming",
            "Computational modeling",
            "Particle swarm optimization"
        ],
        "authors": [
            {
                "name": "Jie Tian",
                "org": "College of Mechanical Engineering, Taiyuan University of Science and Technology, Taiyuan 030024, China."
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Jianchao Zeng",
                "org": "College of Mechanical Engineering, Taiyuan University of Science and Technology, Taiyuan 030024, China, and also with the School of Computer Science and Control Engineering, North University of China, Taiyuan 030051, China."
            },
            {
                "name": "Chaoli Sun",
                "org": "Department of Computer Science and Technology, Taiyuan University of Science and Technology, Taiyuan 030024, China."
            },
            {
                "name": "Yaochu Jin",
                "org": "Department of Computer Science, University of Surrey, Guildford, GU2 7XH, UK, and also with the Department of Computer Science and Technology, Taiyuan University of Science and Technology, Taiyuan 030024, China."
            }
        ],
        "venue": "IEEE Transactions on Evolutionary Computation",
        "year": 2018
    },
    "zbNLqPy9": {
        "id": "zbNLqPy9",
        "title": "PERFORMANCE-DEPENDENT ADAPTIVE PARTICLE SWARM OPTIMIZATION",
        "abstract": "The swarm collective behaviors, such as birds flocking and fish schooling, are complex, dynamic and adaptive processes, in which the dierences among individu-",
        "keywords": [
            "personal dierences",
            "performance is problem-dependent. keywords: particle swarm optimization"
        ],
        "authors": [
            {
                "name": "Xingjuan CAI",
                "org": "Division of System|Simulation and Computer Application|Taiyuan University of Science and Technology"
            },
            {
                "name": "Zhihua CUI",
                "org": "Division of System|Simulation and Computer Application|Taiyuan University of Science and Technology"
            },
            {
                "name": "Jianchao ZENG",
                "org": "Division of System|Simulation and Computer Application|Taiyuan University of Science and Technology"
            },
            {
                "name": "Ying Tan",
                "org": "Division of System|Simulation and Computer Application|Taiyuan University of Science and Technology"
            }
        ],
        "venue": "",
        "year": 0
    },
    "XLPM0GgM": {
        "id": "XLPM0GgM",
        "title": "Group-decided particle swarm optimization",
        "abstract": "In particle swarm optimization algorithm, computational efficiency is one key problem to affect the algorithm performance due to the dynamic balance between exploration and exploitation capabilities. In this paper, a new strategy, one group-decided position is regarded as the attraction center to provide more chances to search the local optimum. This group-decided position is estimated with all particles' fitness change ratios. Simulation results show it is effective and efficiency.",
        "keywords": [
            "particles fitness change ratios",
            "computational efficiency",
            "particle swarm optimisation",
            "group decided particle swarm optimization",
            "exploration capability",
            "exploitation capability",
            "group theory"
        ],
        "authors": [
            {
                "name": "Hongjuan Yang",
                "org": ""
            },
            {
                "name": "Zhihua Cui",
                "org": ""
            },
            {
                "name": "Liang Wang",
                "org": ""
            },
            {
                "name": "Xingjuan Cai",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Jianna Wu",
                "org": ""
            }
        ],
        "venue": "IEEE ICCI*CC",
        "year": 2011
    },
    "yqegu5pF": {
        "id": "yqegu5pF",
        "title": "Semi-supervised learning assisted particle swarm optimization of computationally expensive problems.",
        "abstract": "In many real-world optimization problems, it is very time-consuming to evaluate the performance of candidate solutions because the evaluations involve computationally intensive numerical simulations or costly physical experiments. Therefore, standard population based meta-heuristic search algorithms are not best suited for solving such expensive problems because they typically require a large number of performance evaluations. To address this issue, many surrogate-assisted meta-heuristic algorithms have been proposed and shown to be promising in achieving acceptable solutions with a small computation budget. While most research focuses on reducing the required number of expensive fitness evaluations, not much attention has been paid to take advantage of the large amount of unlabelled data, i.e., the solutions that have not been evaluated using the expensive fitness functions, generated during the optimization. This paper aims to make use of semi-supervised learning techniques that are able to enhance the training of surrogate models using the unlabelled data together with the labelled data in a surrogate-assisted particle swarm optimization algorithm. Empirical studies on five 30-dimensional benchmark problems show that the proposed algorithm is able to find high-quality solutions for computationally expensive problems on a limited computational budget.\n\n",
        "keywords": "",
        "authors": [
            {
                "name": "Chaoli Sun",
                "org": "Taiyuan University of Science and Technology, Taiyuan, China and Northeastern University, Shenyang, China"
            },
            {
                "name": "Yaochu Jin",
                "org": "University of Surrey, Guildford, United Kingdom and Taiyuan University of Science and Technology, Taiyuan, China"
            },
            {
                "name": "Ying Tan",
                "org": "Taiyuan University of Science and Technology, Taiyuan, China"
            }
        ],
        "venue": "GECCO",
        "year": 2018
    },
    "0x6Q9KJs": {
        "id": "0x6Q9KJs",
        "title": "Artificial physics optimization algorithm with a feasibility-based rule for constrained optimization problems",
        "abstract": "Artificial Physics Optimization (APO) Algorithm is a novel population-based stochastic algorithm for solving the unconstrained global problems. This paper first presents a simple mechanism to handle constrained optimization problems with APO. A feasibility-based rule is employed, because this rule can guide the swarm quickly to the feasible region and need not additional penalty parameters. The mass formula is constructed based on this rule, the feasible and infeasible individuals' mass are calculated with different mass formulas. The force direction of the individual is determined based on the feasibility-based rule. The simulation results and comparisons with other methods in the literature show the feasibility, effectiveness, and efficiency of the proposed APO algorithm. \u00a92010 IEEE.",
        "keywords": [
            "artificial physics optimization",
            "constrained optimization",
            "feasibility rule",
            "force",
            "mass",
            "stochastic processes",
            "genetics"
        ],
        "authors": [
            {
                "name": "Jian Yin",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Liping Xie",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Jianchao Zeng",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Ying Tan",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            }
        ],
        "venue": "Proceedings - 2010 IEEE International Conference on Intelligent Computing and Intelligent Systems, ICIS 2010",
        "year": 2010
    },
    "ETQWB9pY": {
        "id": "ETQWB9pY",
        "title": "Hybrid group search optimiser with quadratic interpolation method and its application",
        "abstract": "Group Search Optimiser (GSO) is a new swarm intelligence optimiser algorithm inspired by animal social behaviours. In this paper, we proposed two variants of GSO to improve its search capability, and applied them to solving non-linear equations. Producers in the GSO are like the eyes of animals, which determine the \"\u00ef\u622e\u8075food' position and the movement direction of scroungers. However, due to the random sample mechanism, the computational efficiency is poor. To improve its search efficiency, a new GSO based on quadratic interpolation method (QIGSO) is proposed, in which the estimated position with quadratic interpolation theory is used to replace the random point in each iteration to increase the speed of convergence. Furthermore, the steepest gradient descent method is also incorporated into QIGSO (QIGSO_SDO) to improve the local search capability. Numerical simulation and a special problem about radar detection are used to test the proposed two variants.",
        "keywords": [
            "search capability",
            "quadratic interpolation theory",
            "new gso",
            "new swarm intelligence optimiser",
            "estimated position",
            "computational efficiency",
            "search efficiency",
            "hybrid group search optimiser",
            "quadratic interpolation method",
            "local search capability",
            "random point",
            "quadratic interpolation",
            "nonlinear equations",
            "gso"
        ],
        "authors": [
            {
                "name": "Jian Yao",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No.66, Waliu Road, Wanbailin District, Taiyuan, Shanxi 030024, China"
            },
            {
                "name": "Zhihua Cui",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No.66, Waliu Road, Wanbailin District, Taiyuan, Shanxi 030024, China"
            },
            {
                "name": "Zhanhong Wei",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No.66, Waliu Road, Wanbailin District, Taiyuan, Shanxi 030024, China"
            },
            {
                "name": "Ying Tan",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No.66, Waliu Road, Wanbailin District, Taiyuan, Shanxi 030024, China"
            }
        ],
        "venue": "IJWMC",
        "year": 2011
    },
    "d67ILmuP": {
        "id": "d67ILmuP",
        "title": "Particle swarm optimization with self-adjusting cognitive selection strategy",
        "abstract": "Cognitive coefficient is an important parameter used to control the weight of personal historical best position, therefore many selection adjustments are proposed. However, these strategies are either deterministic or stochastic. Due to the requirement for the problem-based tuning of parameters, this paper introduces a novel self-adjusting cognitive selection strategy (SCSS). It employs an information index to judge the value for cognitive coefficient of each particle associated with the best location itself. Furthermore, a mutation strategy is introduced to avoid premature convergence, and a modified version of particle swarm optimization combined with SCSS and mutation is proposed. Simulation results show the proposed method outperforms for multi-modal benchmarks with many local optimum. ICIC International \u00a9 2008.",
        "keywords": [
            "Information index",
            "Mutation operator",
            "Particle swarm optimization",
            "Self-adjusting cognitive selection strategy"
        ],
        "authors": [
            {
                "name": "Xingjuan Cai",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Zhihua Cui",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Jianchao Zeng",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Ying Tan",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            }
        ],
        "venue": "International Journal of Innovative Computing, Information and Control",
        "year": 2008
    },
    "7m07tO4r": {
        "id": "7m07tO4r",
        "title": "A study on the effect of V max in Artificial physics optimization algorithm with high dimension",
        "abstract": "Velocity threshold v max is an important parameter of Artificial physics optimization. Different from other parameters, it affects the algorithm performance by restricting the moving size and direction of each particle. Because of the complex optimisation problems, the proper v max setting may provide a reasonable solution within an allowed generation. However, up to now, there are only few scholars who are concerned in this problem. Therefore, in this paper, the authors investigate two selection principles of v max (a canstant v max and an adaptive v max) with high dimension on numerical optimisation problems. To make a deep insight, the test suit consists of three different type benchmarks: unimodel, multi-modal functions with a few local optima and multi-modal functions with many local optima. Simulation results show an adaptive v max may generally obtain the satisfied solution within the allowed iterations. \u00a9 2011 IEEE.",
        "keywords": [
            "apo",
            "artificial physics optimization",
            "global optimization",
            "high dimensional benchmarks",
            "velocity threshold",
            "algorithm design and analysis",
            "physics",
            "algorithm design",
            "benchmark testing",
            "vectors",
            "pattern recognition",
            "force",
            "optimization",
            "satisfiability"
        ],
        "authors": [
            {
                "name": "Liping Xie",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Ying Tan",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Jianchao Zeng",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            }
        ],
        "venue": "Proceedings of the 2011 International Conference of Soft Computing and Pattern Recognition, SoCPaR 2011",
        "year": 2011
    },
    "EHbqpGjd": {
        "id": "EHbqpGjd",
        "title": "Individual predicted integral-controlled particle swarm optimisation",
        "abstract": "Integral-controlled particle swarm optimisation (ICPSO) is a novel variant of particle swarm optimisation by incorporating two integral controllers into the methodology. Although the population diversity of ICPSO is large enough, the performance is not always well when dealing with multi-modal problems, the reason is partly due to the wrong guiding direction dominated by the best location found by entire swarm. Therefore, in this paper, a new strategy, quadratic interpolation method, is introduced to estimate the exact local optima in the best location neighbours. Simulation results show this new variant provide an efficient local search capability than other three variants of particle swarm optimisation when solving multi-modal numerical problems.",
        "keywords": [
            "multi-modal numerical problem",
            "entire swarm",
            "efficient local search capability",
            "integral-controlled particle swarm optimization",
            "best location",
            "particle swarm optimisation",
            "local optima.",
            "integral-controlled particle swarm optimisation",
            "multi-modal problem",
            "new strategy",
            "exact local optimum",
            "best location neighbour",
            "quadratic interpolation method",
            "simulation",
            "local search",
            "quadratic interpolation",
            "local optima"
        ],
        "authors": [
            {
                "name": "Xingjuan Cai",
                "org": "Division of System Simulation and Computer Application, Taiyuan University of Science and Technology, 030024, China."
            },
            {
                "name": "Ying Tan",
                "org": "Division of System Simulation and Computer Application, Taiyuan University of Science and Technology, 030024, China"
            }
        ],
        "venue": "International Journal of Innovative Computing and Applications",
        "year": 2009
    },
    "lYZhqBMm": {
        "id": "lYZhqBMm",
        "title": "Particle swarm optimization with active congregation",
        "abstract": "Particle swarm optimization with passive congregation (PSOPC) is a novel variant by incorporating a passive congregation. However, we argue the analysis for the third item velocity update equation. In PSOPC, this item is taken as an active congregation, but we think it should be a passive congregation item. Following this analysis, a new variant with active congregation (PSOAC) is proposed by incorporating an additional active congregation item. To provide a balance between exploration and exploitation, the active contribution index is designed. Simulation results show the proposed variant is more effective than other three variants of particle swarm optimization especially for multi-modal numerical problems. ICIC International \u00a9 2010 ISSN 1881-803X.",
        "keywords": [
            "Active congregation",
            "Active contribution index",
            "Particle swarm optimization"
        ],
        "authors": [
            {
                "name": "Zhihua Cui",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Liang Wang",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Ying Tan",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            }
        ],
        "venue": "ICIC Express Letters",
        "year": 2010
    },
    "4te2oS7b": {
        "id": "4te2oS7b",
        "title": "A diversity-guided particle swarm optimizer for dynamic environments",
        "abstract": "For many real-world changeable problems over time, the goal of optimization is not only to acquire an optimal solution, but also to track its progression through the search space as closely as possible. In this paper, an improved detection technique at the particle level is designed. Then, a new method of response, learning from the changing global optimum for new environments guided by population diversity, is designed. It defines response condition as well as part of particles to be reset and flying direction after a change. Then, the parabolic benchmark functions with various severities are used to test, compared with the Eberhart-PSO and APSO, and the results show the modified strategies are effective in tracking changes.",
        "keywords": [
            "particle level",
            "optimal solution",
            "response condition",
            "real-world changeable problem",
            "diversity-guided particle swarm optimizer",
            "parabolic benchmark function",
            "improved detection technique",
            "new method",
            "dynamic environment",
            "modified strategy",
            "population diversity",
            "new environment",
            "search space"
        ],
        "authors": [
            {
                "name": "Jing Hu",
                "org": "School of Computer Science and Technology, Taiyuan University of Science and Technology, Taiyuan"
            },
            {
                "name": "Jianchao Zeng",
                "org": "School of Computer Science and Technology, Taiyuan University of Science and Technology, Taiyuan"
            },
            {
                "name": "Ying Tan",
                "org": "School of Computer Science and Technology, Taiyuan University of Science and Technology, Taiyuan"
            }
        ],
        "venue": "LSMS (1)",
        "year": 2007
    },
    "QaPdhDpl": {
        "id": "QaPdhDpl",
        "title": "The convergence analysis of artificial physics optimisation algorithm",
        "abstract": "Artificial physics optimisation (APO) algorithm is a novel population-based stochastic algorithm based on physicomimetics framework for multidimensional search and optimisation. APO invokes a gravitational metaphor in which the force of gravity may be attractive or repulsive, the aggregate effect of which is to move individuals toward local and global optima. A proof of convergence is presented that reveals the conditions under which APO is guaranteed to converge. These convergence conditions indicate that some individuals have convergence behaviours whereas other individuals have divergent behaviours in APO system. According to the character, it can be proved that APO algorithm converge to the vicinity of global optimum with probability one based on the related knowledge of probability theory, which is proposed in brief. By regarding each individual|s position on each evolutionary step as a stochastic vector, APO algorithm determined by non-negative real parameter tuple {mi, w, G} is analysed using discrete-time linear system theory. The convergent condition of APO algorithm and corresponding parameter selection guidelines are derived. The simulation results show that the convergent condition is effective in guiding the parameter selection of APO algorithm and can help to explain why those parameters work well.",
        "keywords": [
            "apo algorithm converge",
            "parameter selection",
            "convergence behaviour",
            "apo system",
            "apo algorithm",
            "artificial physics optimisation algorithm",
            "non-negative real parameter tuple",
            "convergence condition",
            "stochastic algorithm",
            "convergence analysis",
            "convergent condition",
            "corresponding parameter selection guideline",
            "convergence",
            "physicomimetics"
        ],
        "authors": [
            {
                "name": "Liping Xie",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No. 66 Waliu Road, Wanbailin District, Taiyuan, Shanxi, 030024, China."
            },
            {
                "name": "Ying Tan",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No. 66 Waliu Road, Wanbailin District, Taiyuan, Shanxi, 030024, China."
            },
            {
                "name": "Jianchao Zeng",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No. 66 Waliu Road, Wanbailin District, Taiyuan, Shanxi, 030024, China."
            },
            {
                "name": "Zhihua Cui",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No. 66 Waliu Road, Wanbailin District, Taiyuan, Shanxi, 030024, China"
            }
        ],
        "venue": "IJIIDS",
        "year": 2011
    },
    "I71LDTzZ": {
        "id": "I71LDTzZ",
        "title": "Mass functions design of artificial physics optimisation algorithm for constrained optimisation problem",
        "abstract": "Artificial physics optimisation APO is a novel population-based stochastic algorithm inspired by physicomimetics. APO with the feasibility and dominance method EAD-APO is employed to solve constrained optimisation problems. In EAD-APO, the mass of each feasible individual corresponds to a user-defined function of the value of an objective to be optimised, and the mass of each infeasible individual corresponds to a user-defined function of the constraint violation value, which can supply some important information for searching global optima. There are many functions can be used as mass function, and no doubt some will be better than others for specific optimisation problems or perhaps classes of problems. This paper proposes the basic regulation and design method of mass function, and classifies mass functions into three different types of curvilinear functions according to their curvilinear styles, such as linear function, convex function, and concave function. Simulation results show the mass functions with concave curve may generally obtain the satisfied solution within the allowed iterations.",
        "keywords": [
            "linear function",
            "convex function",
            "user-defined function",
            "specific optimisation problem",
            "curvilinear function",
            "concave curve",
            "artificial physics optimisation algorithm",
            "concave function",
            "optimisation problem",
            "mass functions design",
            "artificial physics optimisation",
            "mass function"
        ],
        "authors": [
            {
                "name": "Liping Xie",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No. 66 Waliu Road, Wanbailin District, Taiyuan, Shanxi, 030024, China"
            },
            {
                "name": "Jian Yin",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No. 66 Waliu Road, Wanbailin District, Taiyuan, Shanxi, 030024, China"
            },
            {
                "name": "Hongli Zhang",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No. 66 Waliu Road, Wanbailin District, Taiyuan, Shanxi, 030024, China"
            },
            {
                "name": "Ying Tan",
                "org": "Institute of Computer Science and Technology, Taiyuan University of Science and Technology, No. 66 Waliu Road, Wanbailin District, Taiyuan, Shanxi, 030024, China"
            }
        ],
        "venue": "IJCAT",
        "year": 2013
    },
    "Fz2gc9sS": {
        "id": "Fz2gc9sS",
        "title": "Artificial Physics Optimization Algorithm for Global Optimization",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "liping xie",
                "org": "taiyuan university of science and technology"
            },
            {
                "name": "ying tan",
                "org": ""
            },
            {
                "name": "jianchao zeng",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2011
    },
    "HCrTFCzC": {
        "id": "HCrTFCzC",
        "title": "An Artificial Physics Optimization Algorithm for Multi-Objective Problems Based on Virtual Force Sorting Proceedings",
        "abstract": "\n In order to maintain the diversity of non-dominated solutions in multi-objective optimization algorithms efficiently the authors\n have proposed a multi-objective artificial physics optimization algorithm based on virtual force sorting (VFMOAPO). Adopting\n quick-sort idea, the individuals in non-dominated solutions set were sorted by the total virtual force exerting on the other\n individuals. So the non-dominated solution set was pruned and the individual with the maximal sum of virtual force exerting\n on the other individuals was selected as the global best solution. Some benchmark functions were tested for comparing the\n performance of VFMOAPO with MOPSO, NSGA and SPEA. The simulation results show the algorithm is feasible and competitive.\n \n ",
        "keywords": [
            "multi-objective optimization",
            "quick-sort",
            "diversity.",
            "virtual force",
            "artificial physics optimization",
            "multi objective optimization"
        ],
        "authors": [
            {
                "name": "Yan Wang",
                "org": "College of Electrical and Information Engineering, Lanzhou University of Technology, Lanzhou, China"
            },
            {
                "name": "Jian-chao Zeng",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, Taiyuan, China"
            },
            {
                "name": "Ying Tan",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, Taiyuan, China"
            }
        ],
        "venue": "SEMCCO",
        "year": 2010
    },
    "gA5WSAe3": {
        "id": "gA5WSAe3",
        "title": "Particle swarm optimizer based on diversity of particle in dynamic environments",
        "abstract": "To the shortages existing among the current environmental detection and response techniques, an improved detection method based on the particle information was developed, which not only could reduce the optimization cost but also could make up the limitation of the usual detection methods. At the same time, a new response method combined with population diversity and escaping behavior was designed. The improved detection and response algorithms were applied to solve various parabola functions with complex dynamic changes, and the simulation results show the proposed algorithm is effective in dynamic environments.",
        "keywords": [
            "Diversity",
            "Dynamic environments",
            "Escape",
            "Particle swarm optimization"
        ],
        "authors": [
            {
                "name": "Jing Hu",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "ZENG Jian-chao",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Ying Tan",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            }
        ],
        "venue": "Xitong Fangzhen Xuebao / Journal of System Simulation",
        "year": 2007
    },
    "Ktms4h3l": {
        "id": "Ktms4h3l",
        "title": "Surrogate-assisted hierarchical particle swarm optimization.",
        "abstract": "Abstract   Meta-heuristic algorithms, which require a large number of fitness evaluations before locating the global optimum, are often prevented from being applied to computationally expensive real-world problems where one fitness evaluation may take from minutes to hours, or even days. Although many surrogate-assisted meta-heuristic optimization algorithms have been proposed, most of them were developed for solving expensive problems up to 30 dimensions. In this paper, we propose a surrogate-assisted hierarchical particle swarm optimizer for high-dimensional problems consisting of a standard particle swarm optimization (PSO) algorithm and a social learning particle swarm optimization algorithm (SL-PSO), where the PSO and SL-PSO work together to explore and exploit the search space, and simultaneously enhance the global and local performance of the surrogate model. Our experimental results on seven benchmark functions of dimensions 30, 50 and 100 demonstrate that the proposed method is competitive compared with the state-of-the-art algorithms under a limited computational budget.",
        "keywords": "",
        "authors": [
            {
                "name": "Haibo Yu",
                "org": "Department of Mechanical Engineering, Taiyuan University of Science and Technology, Taiyuan 030024, China"
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Jianchao Zeng",
                "org": "Department of Mechanical Engineering, Taiyuan University of Science and Technology, Taiyuan 030024, China"
            },
            {
                "name": "Chaoli Sun",
                "org": "Department of Computer Science and Technology, Taiyuan University of Science and Technology, Taiyuan 030024, China"
            },
            {
                "name": "Yaochu Jin",
                "org": "Department of Computer Science, University of Surrey, Guildford GU2 7XH, UK"
            }
        ],
        "venue": "Inf. Sci.",
        "year": 2018
    },
    "ZvjeLYWa": {
        "id": "ZvjeLYWa",
        "title": "Clustering-based evolution control for surrogate-assisted particle swarm optimization.",
        "abstract": "When using a fixed number of neighbors for training a local surrogate model in surrogate assisted evolutionary optimization algorithms, it may suffer from the large uncertainty because the actual distribution of candidateu0027s neighborhood may be neglected. In this paper, we propose to firstly analyze the distribution characteristics of candidateu0027s neighborhood through a modified overlapping clustering method before training a local surrogate, and then use the clustering based evolution control strategy or model management strategy to facilitate the evolutionary algorithm to converge to the right optimum. Simulation results on four widely used benchmark functions demonstrate the efficacy of the proposed method.",
        "keywords": "",
        "authors": [
            {
                "name": "Haibo Yu",
                "org": "School of Mechanical Engineering, Taiyuan University of Science and Technology, 030024 China"
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Chao-Li Sun",
                "org": "School of Computer Science and Technology, Taiyuan University of Science and Technology, 030024 China"
            },
            {
                "name": "Jianchao Zeng",
                "org": "School of Computer Science and Control Engineering, North University of China, Taiyuan, 030051 China"
            }
        ],
        "venue": "CEC",
        "year": 2017
    },
    "qbacoEyG": {
        "id": "qbacoEyG",
        "title": "Particle swarm optimisation based on self-organisation topology driven by different fitness rank",
        "abstract": "To explore the relations between the population structure and the performance of the particle swarm optimisation (PSO), the self-organisation population structure driven by fitness rank (SOTDFR) is developed. Meanwhile, to improve the performance of PSO, under invariable network size, the SOTDFR evolution involves two kinds of operations: adding and removing link. Moreover, due to the particles' fitness rank impacting heavily on the SOTDFR evolution, two kinds of fitness rank are designed and also SOTDFR according to different fitness rank designs is referred to as VSOTDFR and UVSOTDFR respectively. To make a deep insight, VSOTDFR-based PSO and UVSOTDFR-based PSO are used to solve two types of benchmarks: unimodal and multimodal functions. Simulation results demonstrate that UVSOTDFR-based PSO can generally obtain the better solution than VSOTDFR-based PSO within the allowed iterations. In addition, the performances of the UVSOTDFR-based PSO and some variants of PSO are compared. The simulation results show that UVSOTDFR-based PSO is competitive.",
        "keywords": [
            "population structure",
            "VSOTDFR-based PSO",
            "fitness rank",
            "deep insight",
            "UVSOTDFR-based PSO",
            "simulation result",
            "different fitness rank design",
            "better solution",
            "self-organisation topology",
            "particle swarm optimisation",
            "self-organisation population structure",
            "SOTDFR evolution"
        ],
        "authors": [
            {
                "name": "Simin Mo",
                "org": "College of Electrical and Information Engineering, Lanzhou University of Technology, Lanzhou, 730050, China/ Complex System and Computational Intelligence Laboratory, Taiyuan University of Science ..."
            },
            {
                "name": "Jianchao Zeng",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No. 66 Waliu Road, Wanbailin District, Taiyuan, Shanxi, 030024, China."
            },
            {
                "name": "Ying Tan",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No. 66 Waliu Road, Wanbailin District, Taiyuan, Shanxi, 030024, China"
            }
        ],
        "venue": "IJCSE",
        "year": 2011
    },
    "TIpiPCww": {
        "id": "TIpiPCww",
        "title": "The convergence analysis and parameter selection of artificial physics optimization algorithm",
        "abstract": "Artificial Physics Optimization (APO) algorithm is a population-based stochastic algorithm based on Physicomimetics framework. The algorithm utilizes an attraction-repulsion mechanism to move individuals toward optimality. The convergence analysis of APO algorithm is made theoretically. By regarding each individual's position on each evolutionary step as a stochastic vector, APO algorithm determined by non-negative real parameter tuple {w, G} is analyzed using discrete-time linear system theory. The convergent condition of APO algorithm and corresponding parameter selection guidelines are derived. The simulation results show that the convergent condition is effective in guiding the parameter selection of APO algorithm and can help to explain why those parameters work well.",
        "keywords": [
            "stochastic programming",
            "linear systems",
            "stochastic vector",
            "vectors",
            "evolutionary computation",
            "convergence",
            "discrete time"
        ],
        "authors": [
            {
                "name": "Liping Xie",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Ying Tan",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Jianchao Zeng",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            }
        ],
        "venue": "2010 International Conference on Modelling, Identification and Control, ICMIC 2010",
        "year": 2010
    },
    "QTeUklif": {
        "id": "QTeUklif",
        "title": "Artificial physics optimisation: a brief survey",
        "abstract": "As a new swarm intelligence algorithm, artificial physics optimisation (APO) is based on physicomimetics to solve global optimisation problems. A relationship of mapping between AP approach and population-based optimisation algorithm is constructed by comparing the similarities and differences of physical individual and ideal particle. Each particle is treated as physical individual with mass, position and velocity. Force law and mass function are preliminary analysed through providing several selection strategies. The convergent condition of APO is derived by theoretically analysing. The vector model of APO is constructed, an extended APO including each individual's best history position and a local APO with some simple topologies are presented inspired by the useful experiences and limited sense and interaction among individuals in swarm foraging processes. The implementations of APO and its improvements are applied to multidimensional numeric benchmark functions and the simulation results confirm APO is effective.",
        "keywords": [
            "brief survey",
            "extended apo",
            "global optimisation problem",
            "ideal particle",
            "local apo",
            "physical individual",
            "new swarm intelligence algorithm",
            "population-based optimisation algorithm",
            "best history position",
            "mass function",
            "artificial physics optimisation",
            "swarm intelligence",
            "simulation",
            "physicomimetics"
        ],
        "authors": [
            {
                "name": "Liping Xie",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No. 66 Waliu Road, Wanbailin District, Taiyuan, Shanxi, 030024, China."
            },
            {
                "name": "Ying Tan",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No. 66 Waliu Road, Wanbailin District, Taiyuan, Shanxi, 030024, China."
            },
            {
                "name": "Jianchao Zeng",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No. 66 Waliu Road, Wanbailin District, Taiyuan, Shanxi, 030024, China."
            },
            {
                "name": "Zhihua Cui",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No. 66 Waliu Road, Wanbailin District, Taiyuan, Shanxi, 030024, China"
            }
        ],
        "venue": "IJBIC",
        "year": 2010
    },
    "817YaBeB": {
        "id": "817YaBeB",
        "title": "Self-adaptive PID-controlled particle swarm optimization",
        "abstract": "As a new version of particle swarm optimization (PSO), PID-controlled PSO introduces the concept of controller into the algorithm structure. However, with the introduction of PID controller, three additional parameters are incorporated into the algorithm. Thus, how to provide a proper selection of these parameters is an important problem to affect the algorithm efficiency. In this paper, the relationships among these parameters are conducted by the stability theory. Further, a self-adaptive parameter selection strategy is proposed. Simulation results show the proposed strategy is effective.",
        "keywords": [
            "particle swarm optimization",
            "pid controller",
            "self-adaptive",
            "stability",
            "pid control",
            "adaptive control",
            "stability theory"
        ],
        "authors": [
            {
                "name": "Xingjuan Cai",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Zhihua Cui",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Jianchao Zeng",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Ying Tan",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            }
        ],
        "venue": "Proceedings of the 26th Chinese Control Conference, CCC 2007",
        "year": 2007
    },
    "0cZ7gvG1": {
        "id": "0cZ7gvG1",
        "title": "Group-decided Watts-Strogatz particle swarm optimisation",
        "abstract": "Particle swarm optimisation (PSO) is a novel swarm intelligent algorithm inspired by fish schooling and birds flocking. Due to the complex nature of engineering optimisation tasks, the standard version can not always meet the optimisation requirements. Therefore, in this paper, a new group decision mechanism is introduced to PSO to enhance the escaping capability from local optimum. Furthermore, a Watts-Strogatz small-world model is incorporated into PSO to increase the population diversity. Seven famous numerical benchmarks are used to test the new algorithm. Simulation results show that it achieves the best performance when compared with three other variants of particle swarm optimisation especially for multi-modal problems.",
        "keywords": [
            "new group decision mechanism",
            "complex nature",
            "Watts-Strogatz small-world model",
            "optimisation requirement",
            "famous numerical benchmarks",
            "Group-decided Watts-Strogatz particle swarm",
            "new algorithm",
            "best performance",
            "novel swarm intelligent algorithm",
            "particle swarm optimisation",
            "engineering optimisation task"
        ],
        "authors": [
            {
                "name": "Xiaobo Zhou",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, 030024, China."
            },
            {
                "name": "Ying Tan",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, 030024, China"
            }
        ],
        "venue": "IJCSE",
        "year": 2011
    },
    "aPUoKv1Z": {
        "id": "aPUoKv1Z",
        "title": "A generation-based optimal restart strategy for surrogate-assisted social learning particle swarm optimization.",
        "abstract": "Abstract   Evolutionary algorithm provides a powerful tool to the solution of modern complex engineering optimization problems. In general, a great deal of evaluation effort often requires to be made in evolutionary optimization to locate a reasonable optimum. This poses a serious challenge to extend its application to computationally expensive problems. To alleviate this difficulty, surrogate-assisted evolutionary algorithms (SAEAs) have drawn great attention over the past decades. However, in order to ensure the performance of SAEAs, the use of appropriate model management is indispensable. This paper proposes a generation-based optimal restart strategy for a surrogate-assisted social learning particle swarm optimization (SL-PSO). In the proposed method, the SL-PSO restarts every few generations in the global radial-basis-function model landscape, and the best sample points archived in the database are employed to reinitialize the swarm at each restart. Promising individual with the best estimated fitness value is chosen for exact evaluation before each restart of the SL-PSO. The proposed method skillfully integrates the restart strategy, generation-based and individual-based model managements into a whole, whilst those three ingredients coordinate with each other, thus offering a powerful optimizer for the computationally expensive problems. To assess the performance of the proposed method, comprehensive experiments are conducted on a benchmark test suit of dimensions ranging from 10 to 100. Experimental results demonstrate that the proposed method shows superior performance in comparison with four state-of-the-art algorithms in a majority of benchmarks when only a limited computational budget is available.",
        "keywords": "",
        "authors": [
            {
                "name": "Haibo Yu",
                "org": "Department of Mechanical Engineering, Taiyuan University of Science and Technology, Taiyuan, 030024, China"
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Chaoli Sun",
                "org": "Department of Computer Science and Technology, Taiyuan University of Science and Technology, Taiyuan, 030024, China"
            },
            {
                "name": "Jianchao Zeng",
                "org": "Department of Mechanical Engineering, Taiyuan University of Science and Technology, Taiyuan, 030024, China"
            }
        ],
        "venue": "Knowl.-Based Syst.",
        "year": 2019
    },
    "uHHFKASS": {
        "id": "uHHFKASS",
        "title": "Comparisons of different kernels in Kriging-assisted evolutionary expensive optimization.",
        "abstract": "Surrogate-assisted evolutionary algorithms (SAEAs) have received increasing attention in recent years. Kriging is one of the most popular surrogate models due to its ability to provide approximation uncertainty as well as the approximation value without additional computational cost. The kernel function used in the Kriging model plays a very important role in Kriging, as it has considerable influence on the approximation performance of Kriging models. However, little work has been dedicated to the efficiency of training the Kriging model and the influence of the kernel function on the performance of SAEAs. In this paper, we conduct extensive empirical experiments to examine the performance of Kriging-assisted SAEAs on a widely used test suite of benchmark problems of a dimension of 20 or 30 using different kernel functions. Detailed analyses of the training efficiency and the performance of Kriging-assisted SAEAs with different kernel functions are given.",
        "keywords": "",
        "authors": [
            {
                "name": "Jie Tian",
                "org": "College of Mechanical Engineering, Taiyuan University of Science and Technology, Taiyuan, 030024 China"
            },
            {
                "name": "Chaoli Sun",
                "org": "Department of Computer Science and Technology, Taiyuan University of Science and Technology, Taiyuan, 030024 China"
            },
            {
                "name": "Jianchao Zeng",
                "org": "School of Computer Science and Control Engineering, North University of China, Taiyuan, 030024 China"
            },
            {
                "name": "Haibo Yu",
                "org": "College of Mechanical Engineering, Taiyuan University of Science and Technology, Taiyuan, 030024 China"
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Yaochu Jin",
                "org": "Department of Computer Science, University of Surrey, Guildford, GU2 7XH, UK"
            }
        ],
        "venue": "SSCI",
        "year": 2017
    },
    "8d8h9MzW": {
        "id": "8d8h9MzW",
        "title": "Nonlinear Time-Varying Stability Analysis of Particle Swarm Optimization",
        "abstract": "As a nonlinear time-varying system, it is hard to make the stability analysis for particle swarm optimization (PSO). In this paper, geometric speed stability analysis is introduced to analyze the stability condition of PSO. According to the condition, a new inertia weight selection strategy is proposed. Simulation results show it is effective.",
        "keywords": [
            "new inertia weight selection",
            "time-varying systems",
            "particle swarm optimisation",
            "nonlinear systems",
            "geometric speed stability analysis",
            "stability condition",
            "nonlinear time-varying stability analysis",
            "stability analysis",
            "inertia weight selection",
            "simulation result",
            "stability",
            "geometry",
            "nonlinear time-varying system",
            "particle swarm optimization",
            "convergence",
            "simulation"
        ],
        "authors": [
            {
                "name": "Weibing Fan",
                "org": ""
            },
            {
                "name": "Zhihua Cui",
                "org": ""
            },
            {
                "name": "Yongjing Chen",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            }
        ],
        "venue": "CASoN",
        "year": 2010
    },
    "GgkCUySc": {
        "id": "GgkCUySc",
        "title": "A study on the effect of vmax in particle swarm optimisation with high dimension",
        "abstract": "Velocity threshold v<SUB align=right>max is an important parameter of particle swarm optimisation. Different from other parameters, it affects the algorithm performance by restricting the moving size and direction of each particle. However, the current results are all with small dimensions no larger than 30. Because of the scientific development, many optimisation tasks are complex, high dimensional multi-modal functions. Therefore, in this paper, the authors investigate the selection principle of v<SUB align=right>max with high dimension on numerical optimisation problems. To make a deep insight, the test suit consists of three different type benchmarks: unimodel, multi-modal functions with a few local optima and multi-modal functions with many local optima. Simulation results show the 10% of the upper bound of the domain may generally obtain the satisfied solution within the allowed iterations.",
        "keywords": [
            "optimisation task",
            "multi-modal function",
            "local optimum",
            "different type benchmarks",
            "SUB align",
            "high dimension",
            "velocity threshold v",
            "particle swarm optimisation",
            "velocity threshold",
            "x. and tan",
            "int. j. bio-inspired",
            "y. xxxx 'a study on the effect of v in particle swarm optimisation with high dimension'",
            "high dimensional multi-modal function",
            "high dimensional benchmarks. reference to this paper should be made as follows: cai",
            "numerical optimisation problem",
            "pso"
        ],
        "authors": [
            {
                "name": "Xingjuan Cai",
                "org": "Division of System Simulation and Computer Application, Taiyuan University of Science and Technology, Shanxi, 030024, China."
            },
            {
                "name": "Ying Tan",
                "org": "Division of System Simulation and Computer Application, Taiyuan University of Science and Technology, Shanxi, 030024, China"
            }
        ],
        "venue": "IJBIC",
        "year": 2009
    },
    "6AzmVaSR": {
        "id": "6AzmVaSR",
        "title": "Integral-Controlled Particle Swarm Optimization",
        "abstract": "\n Particle swarm optimization (PSO) is a novel population-based stochastic optimization algorithm. However, it gets easily trapped\n into local optima when dealing with multi-modal high-dimensional problems. To overcome this shortcoming, two integral controllers\n are incorporated into the methodology of PSO, and the integral-controlled particle swarm optimization (ICPSO) is introduced.\n Due to the additional accelerator items, the behavior of ICPSO is more complex, and provides more chances to escaping from\n a local optimum than the standard version of PSO. However, many experimental results show the performance of ICPSO is not\n always well because of the particles\u2019 un-controlled movements. Therefore, a new variant, integral particle swarm optimization\n with dispersed accelerator information (IPSO-DAI) is designed to improve the computational efficiency. In IPSO-DAI, a predefined\n predicted velocity index is introduced to guide the moving direction. If the average velocity of one particle is superior\n to the index value, it will choice a convergent manner, otherwise, a divergent manner is employed. Furthermore, the choice\n of convergent manner or divergent manner for each particle is associated with its performance to fit different living experiences.\n Simulation results show IPSO-DAI is more effective than other three variants of PSO especially for multi-modal numerical problems.\n The IPSO-DAI is also applied to directing the orbits of discrete chaotic dynamical systems by adding small bounded perturbations,\n and achieves the best performance among four different variants of PSO.\n \n ",
        "keywords": [],
        "authors": [
            {
                "name": "Zhihua Cui",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No.66 Waliu Road, Wanbailin District, Taiyuan, Shanxi China 030024"
            },
            {
                "name": "Xingjuan Cai",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No.66 Waliu Road, Wanbailin District, Taiyuan, Shanxi China 030024"
            },
            {
                "name": "Ying Tan",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No.66 Waliu Road, Wanbailin District, Taiyuan, Shanxi China 030024"
            },
            {
                "name": "Jianchao Zeng",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No.66 Waliu Road, Wanbailin District, Taiyuan, Shanxi China 030024"
            }
        ],
        "venue": "",
        "year": 2011
    },
    "ZhBup4Gz": {
        "id": "ZhBup4Gz",
        "title": "Semi-supervised learning assisted particle swarm optimization of computationally expensive problems.",
        "abstract": "In many real-world optimization problems, it is very time-consuming to evaluate the performance of candidate solutions because the evaluations involve computationally intensive numerical simulations or costly physical experiments. Therefore, standard population based meta-heuristic search algorithms are not best suited for solving such expensive problems because they typically require a large number of performance evaluations. To address this issue, many surrogate-assisted meta-heuristic algorithms have been proposed and shown to be promising in achieving acceptable solutions with a small computation budget. While most research focuses on reducing the required number of expensive fitness evaluations, not much attention has been paid to take advantage of the large amount of unlabelled data, i.e., the solutions that have not been evaluated using the expensive fitness functions, generated during the optimization. This paper aims to make use of semi-supervised learning techniques that are able to enhance the training of surrogate models using the unlabelled data together with the labelled data in a surrogate-assisted particle swarm optimization algorithm. Empirical studies on five 30-dimensional benchmark problems show that the proposed algorithm is able to find high-quality solutions for computationally expensive problems on a limited computational budget.\n\n",
        "keywords": "",
        "authors": [
            {
                "name": "Chaoli Sun",
                "org": "Taiyuan University of Science and Technology, Taiyuan, China and Northeastern University, Shenyang, China"
            },
            {
                "name": "Yaochu Jin",
                "org": "University of Surrey, Guildford, United Kingdom and Taiyuan University of Science and Technology, Taiyuan, China"
            },
            {
                "name": "Ying Tan",
                "org": "Taiyuan University of Science and Technology, Taiyuan, China"
            }
        ],
        "venue": "GECCO",
        "year": 2018
    },
    "XRlXvMNs": {
        "id": "XRlXvMNs",
        "title": "Perceptive particle swarm optimization: a new learning method from birds seeking",
        "abstract": "Particle Swarm Optimization (PSO) is a new nature-inspired evolutionary technique simulated with bird flocking and fish schooling. However, the biological model of standard PSO ignores the different decision process of each bird. In nature, if one bird finds some food, generally, it will continue to fly surrounding this spot to find other food, and vice versa. Inspired by this phenomenon, a new swarm intelligent methodology- perceptive particle swarm optimization is designed, in which each particle can apperceive its current status within the whole swarm, and make a dynamic decision by adjusting its next flying direction. Furthermore, a mutation operator is introduced to avoid unsuitable adjustment. Simulation results show the proposed algorithm is effective and efficiency.",
        "keywords": [
            "dynamic decision",
            "biological model",
            "particle swarm optimization",
            "whole swarm",
            "standard pso",
            "current status",
            "new swarm",
            "new learning method",
            "different decision process",
            "perceptive particle swarm optimization",
            "new nature-inspired evolutionary technique",
            "swarm intelligence"
        ],
        "authors": [
            {
                "name": "Xingjuan Cai",
                "org": "College of Electronic Information Engineering, Taiyuan University of Science and Technology, Shanxi, P.R. China"
            },
            {
                "name": "Zhihua Cui",
                "org": "State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an, P.R. China"
            },
            {
                "name": "Jianchao Zeng",
                "org": "Division of System Simulation and Computer Application, Taiyuan University of Science and Technology, Shanxi, P.R. China"
            },
            {
                "name": "Ying Tan",
                "org": "Division of System Simulation and Computer Application, Taiyuan University of Science and Technology, Shanxi, P.R. China"
            }
        ],
        "venue": "IWANN",
        "year": 2007
    },
    "TyB1IZyu": {
        "id": "TyB1IZyu",
        "title": "Granularity-based surrogate-assisted particle swarm optimization for high-dimensional expensive optimization.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jie Tian",
                "org": "School of Information Science and Engineering, Shandong Normal University, Jinan 250300, China"
            },
            {
                "name": "Chaoli Sun",
                "org": "Department of Computer Science and Technology, Taiyuan University of Science and Technology, Taiyuan 030024, China"
            },
            {
                "name": "Ying Tan",
                "org": "Department of Computer Science and Technology, Taiyuan University of Science and Technology, Taiyuan 030024, China"
            },
            {
                "name": "Jianchao Zeng",
                "org": "School of Computer Science and Control Engineering, North University of China, Taiyuan 030051, China"
            }
        ],
        "venue": "Knowl.-Based Syst.",
        "year": 2020
    },
    "FNhER72J": {
        "id": "FNhER72J",
        "title": "A study on the effect of Vmax in Artificial physics optimization algorithm with high dimension.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Liping Xie",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Jianchao Zeng",
                "org": ""
            }
        ],
        "venue": "SoCPaR",
        "year": 2011
    },
    "AYeNysDC": {
        "id": "AYeNysDC",
        "title": "Artificial physics optimisation algorithm guided by diversity",
        "abstract": "In order to avoid the stagnation evolution of APO population, the thinking of dissipative structure theory and population diversity are combined in APO. Firstly, a chaos factor is introduced to judge whether the individuals doing dissipative movement or not, which is defined in a dissipation rule. However, the behaviour of an individual decided by the dissipation rule has blindness. Hence, population diversity is used to guide individual's movement. Then a diversity factor is introduced to judge whether population diversity is good or bad. If population diversity is worse than the diversity factor, individuals will do dissipative movement according to dissipation rule. The proposed algorithm is called APO algorithm guide by diversity APOD. Simulation results show APOD algorithm can improve the population diversity and global search capability of APO algorithm.",
        "keywords": [
            "apo algorithm guide",
            "diversity factor",
            "apo algorithm",
            "artificial physics optimisation algorithm",
            "diversity apod",
            "dissipative movement",
            "apod algorithm",
            "proposed algorithm",
            "population diversity",
            "apo population",
            "dissipation rule",
            "physicomimetics"
        ],
        "authors": [
            {
                "name": "Gangjun Yang",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No. 66, Waliu Road, Wanbailin District, Taiyuan, Shanxi, 030024, China"
            },
            {
                "name": "Liping Xie",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No. 66, Waliu Road, Wanbailin District, Taiyuan, Shanxi, 030024, China"
            },
            {
                "name": "Ying Tan",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No. 66, Waliu Road, Wanbailin District, Taiyuan, Shanxi, 030024, China"
            },
            {
                "name": "Zhihua Cui",
                "org": "Complex System and Computational Intelligence Laboratory, Taiyuan University of Science and Technology, No. 66, Waliu Road, Wanbailin District, Taiyuan, Shanxi, 030024, China"
            }
        ],
        "venue": "IJCAT",
        "year": 2013
    },
    "DzIhgO25": {
        "id": "DzIhgO25",
        "title": "Improved particle swarm optimizer in dynamic environments",
        "abstract": "A usual detection technique of particle swarm optimization in dynamic environments is modified. Then, a new method of response, guided by Dgbest(t) and population diversity, is designed, which not only increases population diversity, but also responds the various changes for dynamic environments in time. Finally, the parabolic benchmark functions with various severities are used to test, compared with the Eberhart-PSO and APSO, and the results show the algorithm is effective.",
        "keywords": [
            "Dynamic environments",
            "Particle swarm optimization",
            "Population diversity"
        ],
        "authors": [
            {
                "name": "Jing Hu",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "ZENG Jian-chao",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Ying Tan",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            }
        ],
        "venue": "Xitong Gongcheng Lilun yu Shijian/System Engineering Theory and Practice",
        "year": 2008
    },
    "DajtlhxO": {
        "id": "DajtlhxO",
        "title": "A Hybrid Vector Artificial Physics Optimization with One-Dimensional Search Method",
        "abstract": "The direction of each individual velocity vector is very useful information for search in Artificial Physics Optimization (APO) algorithm. APO's simple way to dealing with the errant individual exceeded the lower or upper bounds constrains changes the direction of its motion vector. A shrinkage coefficient is introduced to ensure that each individual is within the decision space without changing its direction. One-dimensional search method is merged into the vector model of APO (VM-APO) to improve its local search capability. The simulation results confirm that the performance of the hybrid vector APO with one-dimensional search method is effective.",
        "keywords": [
            "hybrid vector artificial physics",
            "global optimization",
            "optimisation",
            "newton's second law",
            "motion vector",
            "one dimensional search method",
            "physics",
            "vector model",
            "velocity vector",
            "one-dimensional search method",
            "hybrid vector artificial physics optimization",
            "search problems",
            "physicomimetics",
            "individual velocity vector",
            "errant individual",
            "artificial physics optimization",
            "local search capability",
            "virtual force",
            "decision space",
            "hybrid vector apo",
            "shrinkage coefficient",
            "swarm intelligence",
            "local search",
            "upper bound",
            "algorithm design and analysis",
            "force",
            "optimization"
        ],
        "authors": [
            {
                "name": "Gangjun Yang",
                "org": ""
            },
            {
                "name": "Liping Xie",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Jianchao Zeng",
                "org": ""
            }
        ],
        "venue": "CASoN",
        "year": 2010
    },
    "rOwmHMzZ": {
        "id": "rOwmHMzZ",
        "title": "Forecasted Particle Swarm Optimization",
        "abstract": "This paper introduces a novel fitness estimation strategy for particle swarm optimization (PSO) that does not evaluate all new positions, thus operating faster. A fitness and associated reliability value are assigned to each new individual that is only evaluated using the true fitness function if the reliability value is below some threshold. This variant of PSO designs a two-stage convex fitness estimation method. The first stage is used to estimate a visual position's fitness and reliability value, whereas in the second stage, the individual's fitness and reliability value are estimated with this visual position. Simulation results show the proposed algorithm is effective and efficient.",
        "keywords": [
            "particle swarm optimization",
            "new individual",
            "simulation result",
            "forecasted particle swarm optimization",
            "two-stage convex fitness estimation",
            "novel fitness estimation strategy",
            "new position",
            "true fitness function",
            "proposed algorithm",
            "visual position",
            "reliability value",
            "fitness function",
            "convex programming"
        ],
        "authors": [
            {
                "name": "Xingjuan Cai",
                "org": "Taiyuan University of Science and Technology, China"
            },
            {
                "name": "Jianchao Zeng",
                "org": "Taiyuan University of Science and Technology, China"
            },
            {
                "name": "Ying Tan",
                "org": "Taiyuan University of Science and Technology, China"
            }
        ],
        "venue": "ICNC",
        "year": 2007
    },
    "olFNkfJr": {
        "id": "olFNkfJr",
        "title": "Particle swarm optimization using l\u00e9vy probability distribution",
        "abstract": "Velocity threshold is an important parameter to affect the performance of particle swarm optimization. In this paper, a novel velocity threshold automation strategy is proposed by incorporated with L\u00e9vy probability distribution. Different from Gaussian and Cauchy distribution, it has an infinite second moment and is likely to generate an offspring that is far away from its parent. Therefore, this method employs a larger capability of the global exploration by providing a large velocity scale for each particle. Simulation results show the proposed strategy is effective and efficient.",
        "keywords": [
            "particle swarm optimization",
            "vy probability distribution",
            "velocity threshold",
            "important parameter",
            "larger capability",
            "large velocity scale",
            "proposed strategy",
            "cauchy distribution",
            "global exploration",
            "novel velocity threshold automation",
            "probability distribution"
        ],
        "authors": [
            {
                "name": "Xingjuan Cai",
                "org": "Taiyuan University of Science and Technology, Shanxi, P.R. China"
            },
            {
                "name": "Jianchao Zeng",
                "org": "Taiyuan University of Science and Technology, Shanxi, P.R. China"
            },
            {
                "name": "Zhihua Cui",
                "org": "State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an, P.R. China and Taiyuan University of Science and Technology, Shanxi, P.R. China"
            },
            {
                "name": "Ying Tan",
                "org": "Taiyuan University of Science and Technology, Shanxi, P.R. China"
            }
        ],
        "venue": "ISICA",
        "year": 2007
    },
    "XPALdIZ5": {
        "id": "XPALdIZ5",
        "title": "Self-learning Particle Swarm Optimization Based on Environmental Feedback",
        "abstract": "Particle swarm optimization (PSO) simulates the be- haviors of birds \u9647ocking and \u62e2sh schooling. However, its biological background does not concern the environmen- tal affection. Inspired by the interaction between environ- ment and individuals, a new version self-learning par- ticle swarm optimization based on environmental feedback (SL-PSO), is proposed, in which two self-learning strategies are designed so that each particle adjusts its moving direc- tion according to the feedback information from the envi- ronment. Furthermore, a mutation operator is introduced to avoid premature convergence phenomenon. Simulation re- sults show the proposed algorithm is effective and ef\u62e2cient.",
        "keywords": [
            "particle swarm optimization",
            "feedback information",
            "environmental feedback",
            "self-learning strategy",
            "premature convergence phenomenon",
            "new version",
            "biological background",
            "self-learning particle swarm optimization",
            "ticle swarm optimization",
            "proposed algorithm",
            "mutation operator",
            "premature convergence"
        ],
        "authors": [
            {
                "name": "Xingjuan Cai",
                "org": ""
            },
            {
                "name": "Zhihua Cui",
                "org": ""
            },
            {
                "name": "Jianchao Zeng",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            }
        ],
        "venue": "ICICIC '07 Proceedings of the Second International Conference on Innovative Computing, Informatio and Control",
        "year": 2007
    },
    "FkUrheqJ": {
        "id": "FkUrheqJ",
        "title": "Effects of algorithmic parameters on swarm robotic search",
        "abstract": "As one of valid modeling and coordinated controlling tools, the particle swarm optimization algorithm can be extended for applying to task of swarm robotic search. To gain an insight into effects of key parameters on distributed swarm search, a series of simulations are conducted. In such control algorithm, main parameters including communication range, detection radius, and swarm size are paid close attentions. Similar to ideal \"particles\", swarm robots are modeled at an abstract level with the extended particle swarm optimization method. Also, individual robots are designed to be controlled under three-state finite state machine mechanism having SingleSearch, SwarmSearch, and Declaration states. Then, control strategy and algorithm are developed. The statistical results from simulating data indicate the validity of modeling approach. Further, the effects of three parameters on overhead and efficiency of system running come out in compared analysis both of different size swarms and of specific size swarm. \u00a92010 IEEE.",
        "keywords": [
            "algorithmic parameter",
            "particle swarm optimization",
            "swarm robotics",
            "target search",
            "cognitive robotics",
            "algorithm design and analysis",
            "motion control",
            "data models",
            "robot kinematics",
            "mobile robots",
            "finite state machines",
            "robot control"
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Songdong Xue",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Jianchao Zeng",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Jengshyang Pan",
                "org": "National Kaohsiung University of Applied Sciences(National Kaohsiung University of Applied Sciences,^ Natl. Kaohsiung Univ. of Appl. Sci.),Kaohsiung,Taiwan"
            },
            {
                "name": "Tienszu Pan",
                "org": "National Kaohsiung University of Applied Sciences(National Kaohsiung University of Applied Sciences,^ Natl. Kaohsiung Univ. of Appl. Sci.),Kaohsiung,Taiwan"
            }
        ],
        "venue": "2010 IEEE International Conference on Information and Automation, ICIA 2010",
        "year": 2010
    },
    "vZ9L3eCU": {
        "id": "vZ9L3eCU",
        "title": "Global minimum structure optimisation of Lennard-Jones clusters by hybrid PSO",
        "abstract": "Structural optimisation of Lennard-Jones clusters (LJ) is a classical NP-hard problem due to the exponential increased local optima. In this paper, a hybrid particle swarm optimisation (PSO) is designed to solve this problem. To increase the escaping probability from local optimum, each particle maintains two different phase motion: attraction and repulsion in which attraction phase aims to exploitation, while repulsion motion tends to make the exploration capability. To further increase the population diversity, one-Gaussian mutation is applied to the best location found by entire swarm. Then, a well-known local search strategy, limited memory Broyden-Fletcher-Goldfarb-Shanno (L-BFGS) is employed to make an efficient local search. Simulation results show this new hybrid algorithm is effective for LJ2-LJ17 when compared with standard version and original attractive and repulsive PSO. Copyright \u00a9 2011 Inderscience Enterprises Ltd.",
        "keywords": [],
        "authors": [
            {
                "name": "Yongjing Chen",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Zhihua Cui",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Jian Yin",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Ying Tan",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            }
        ],
        "venue": "IJMIC",
        "year": 2011
    },
    "MZe3L1Ha": {
        "id": "MZe3L1Ha",
        "title": "Adaptive Information Granulation in Fitness Estimation for Evolutionary Optimization.",
        "abstract": "Evolutionary algorithms ordinarily need to conduct lots of fitness evaluations, requiring big computational overhead particularly in complex optimization problems. This paper proposes an adaptive information granulation approach which inspired from on the granule computing, and then reduces the expensive original fitness evaluation by the aid of the fitness inheritance strategy based on the proposed adaptive information granulation approach. The proposed algorithm is compared with few fitness inheritance assisted evolutionary algorithm on both traditional benchmark problems with four different dimensions, the CEC 2013 functions and the CEC 2014 expensive optimization test problems with 30 dimensions. Experimental results show both high effectiveness and efficiency with better solutions than those compared algorithm within different finite budget of computation for different benchmark problems. Its advantages are further verified by a real-world light aircraft wing design problem.",
        "keywords": [
            "Fitness inheritance",
            "Information granulation",
            "Key neighbour"
        ],
        "authors": [
            {
                "name": "Jie Tian",
                "org": "Taiyuan University of Science and Technology"
            },
            {
                "name": "Jianchao Zeng",
                "org": "Taiyuan University of Science and Technology"
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Chaoli Sun",
                "org": "Taiyuan University of Science and Technology"
            }
        ],
        "venue": "Wireless Personal Communications",
        "year": 2018
    },
    "RGtYeZy3": {
        "id": "RGtYeZy3",
        "title": "The selection strategy of mass functions in artificial physics optimisation algorithm",
        "abstract": "Inspired by physicomimetics, artificial physics optimisation (APO) is a novel population-based stochastic algorithm. In APO framework, the mass of each individual corresponds to a user-defined function of the value of an objective to be optimised, which can supply some important information for searching global optima. There are many functions that can be used as mass function, and no doubt some will be better than others for specific optimisation problems or perhaps classes of problems. This paper proposes the basic requirement and design method of mass function, and classifies mass functions into four different types of curvilinear functions according to their curvilinear styles, such as linear function, convex function, and concave function, etc. Simulation results show the mass functions with concave curve may generally obtain the satisfied solution within the allowed iterations. \u00a9 2013 Inderscience Enterprises Ltd.",
        "keywords": [],
        "authors": [
            {
                "name": "Liping Xie",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Ying Tan",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Jianchao Zeng",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            },
            {
                "name": "Zhihua Cui",
                "org": "Taiyuan University of Science and Technology(Taiyuan University of Science and Technology),Taiyuan,China"
            }
        ],
        "venue": "IJMIC",
        "year": 2013
    },
    "bz8XqAGl": {
        "id": "bz8XqAGl",
        "title": "Dispersed particle swarm optimization",
        "abstract": "In particle swarm optimization (PSO) literatures, the published social coefficient settings are all centralized control manner aiming to increase the search density around the swarm memory. However, few concerns the useful information inside the particles' memories. Thus, to improve the convergence speed, we propose a new setting about social coefficient by introducing an explicit selection pressure, in which each particle decides its search direction toward the personal memory or swarm memory. Due to different adaptation, this setting adopts a dispersed manner associated with its adaptive ability. Furthermore, a mutation strategy is designed to avoid premature convergence. Simulation results show the proposed strategy is effective and efficient.",
        "keywords": [
            "convergence speed",
            "swarm memory",
            "premature convergence",
            "adaptation",
            "particle swarm optimization",
            "personal memory",
            "centralized control",
            "new setting",
            "centralized control manner",
            "search density",
            "social coefficient setting",
            "proposed strategy",
            "mutation strategy",
            "dispersed control"
        ],
        "authors": [
            {
                "name": "Xingjuan Cai",
                "org": "Division of System Simulation and Computer Application, Taiyuan University of Science and Technology, Taiyuan 030024, P.R. China"
            },
            {
                "name": "Zhihua Cui",
                "org": "State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an 710049, P.R. China and Division of System Simulation and Computer Application, Taiyuan University of Sc ..."
            },
            {
                "name": "Jianchao Zeng",
                "org": "Division of System Simulation and Computer Application, Taiyuan University of Science and Technology, Taiyuan 030024, P.R. China"
            },
            {
                "name": "Ying Tan",
                "org": "Division of System Simulation and Computer Application, Taiyuan University of Science and Technology, Taiyuan 030024, P.R. China"
            }
        ],
        "venue": "Inf. Process. Lett.",
        "year": 2008
    },
    "hWBMCXDY": {
        "id": "hWBMCXDY",
        "title": "Particle Swarm Optimization Based on Self-organizing Topology Driven by Fitness",
        "abstract": "To explore the relation between topologic characteristics of dynamic network and performance of the particle swarm optimization (PSO) algorithm, the population of PSO is viewed as a network where each particle is represented as a node and the network structure changes dynamically as the fitness of particles varies. Moreover, in this paper, the structural changes involve adding and removing the links but the network size remains the same. Then, two kinds of simulations are conducted. The results from one kind focusing on PSO show that the dynamic network is capable of balancing exploration and exploitation so that the performance of PSO can be improved as long as the weight \u03b8 is selected properly. In addition, the results from other kind concerning on topologic characteristics of dynamical network indicate the impact of network structure on algorithm behavior and the law of network evolution.",
        "keywords": [
            "self-adjusting systems",
            "dynamical network",
            "pso algorithm",
            "network structure",
            "particle swarm optimisation",
            "network evolution",
            "self-organizing topology driven by fitness",
            "dynamic network",
            "network size",
            "algorithm behavior",
            "particle swarm optimization algorithm",
            "pso population",
            "network structure changes dynamically",
            "pso show",
            "self-organizing topology",
            "topologic characteristic",
            "particle fitness",
            "topologic characteristics",
            "self-organizing topology driven",
            "particle swarm optimization",
            "indexes",
            "topology",
            "structural change",
            "self organization",
            "network topology",
            "entropy"
        ],
        "authors": [
            {
                "name": "Simin Mo",
                "org": ""
            },
            {
                "name": "Jianchao Zeng",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            }
        ],
        "venue": "CASoN",
        "year": 2010
    },
    "cFQZDAzJ": {
        "id": "cFQZDAzJ",
        "title": "Stochastic Dynamic Step Length Particle Swarm Optimization",
        "abstract": "Stochastic particle swarm optimization is a novel variant of particle swarm optimization that convergent to the global optimum with probability one. However, the local search capability is not always well in some cases, therefore, in this paper, a technique, dynamic step length, is incorporated into the structure of stochastic particle swarm optimization aiming to further improve the performance. In this modification, each particle will adjust its velocity according to its performance. In other words, if it finds a better region, it will make a local search, otherwise, a global search pattern is given. By the way, to combining the advantages between the standard version (with better exploitation capability) and the stochastic version (with better exploration capability), the first half period is used with the standard version incorporated with dynamic step length, while in later generations, the stochastic version with dynamic step length is used to escape from a local optimum. Simulation results show this strategy may provide well balance between exploration and exploitation capabilities, and improve the performance significantly.",
        "keywords": [
            "stochastic processes",
            "better exploitation capability",
            "better region",
            "global search pattern",
            "particle swarm optimisation",
            "length particle swarm optimization",
            "search problems",
            "exploration capability",
            "standard version",
            "dynamic step length",
            "stochastic particle swarm optimization",
            "better exploration capability",
            "local search",
            "local search capability",
            "exploitation capability",
            "stochastic dynamic step",
            "-stochastic particle swarm optimization",
            "stochastic version",
            "particle swarm optimization",
            "mathematical model",
            "simulation"
        ],
        "authors": [
            {
                "name": "Xingjuan Cai",
                "org": ""
            },
            {
                "name": "Zhihua Cui",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            }
        ],
        "venue": "Innovative Computing, Information and Control",
        "year": 2009
    },
    "ZNVSdIO7": {
        "id": "ZNVSdIO7",
        "title": "Optimal iterative learning control design for multi-agent systems consensus tracking.",
        "abstract": "Under a repeatable operation environment, this paper proposes an iterative learning control scheme that can be applied to multi-agent systems to perform consensus tracking under the fixed communication topology. The agent dynamics are modeled by time-varying nonlinear equations which satisfy the global Lipschitz continuous condition. In addition, the desired consensus trajectory is only accessible to a subset of the followers. By using the concept of the graph dependent matrix norm, the convergence conditions can be specified at the agent level, which depend on a set of eigenvalues that are associated with the communication topology. The results are first derived for homogeneous agent systems and then extended to heterogeneous systems. Next, optimal controller gain design methods are proposed in the sense that the  \u03bb -norm of tracking error converges at the fastest rate, which imposes a tightest bounding function for the actual tracking error in the  \u03bb -norm analysis framework. In the end, an illustrative example of a group of heterogeneous agents is provided to demonstrate the effectiveness of the proposed design methods.",
        "keywords": [
            "Iterative learning control",
            "Consensus tracking",
            "Multi-agent systems",
            "Optimal design"
        ],
        "authors": [
            {
                "name": "Shiping Yang",
                "org": ""
            },
            {
                "name": "Jian-Xin Xu",
                "org": ""
            },
            {
                "name": "Deqing Huang",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            }
        ],
        "venue": "Systems & Control Letters",
        "year": 2014
    },
    "q2vzt0Wo": {
        "id": "q2vzt0Wo",
        "title": "A dual-loop iterative learning control for nonlinear systems with hysteresis input uncertainty",
        "abstract": "In this work, a dual-loop iterative learning control (ILC) scheme is designed for a class of nonlinear systems with hysteresis input uncertainty. The two ILC loops are applied to the nominal part and the hysteresis part respectively, to learn their unknown dynamics. Based on the convergence analysis for each single loop, a composite energy function method is then adopted to prove the learning convergence of the dual-loop system in iteration domain. One illustrative example shows that the proposed dual learning control scheme can work well under hysteresis input uncertainty.",
        "keywords": [
            "adaptive control",
            "control nonlinearities",
            "control system synthesis",
            "hysteresis",
            "iterative methods",
            "learning systems",
            "nonlinear control systems",
            "uncertain systems",
            "composite energy function method",
            "dual-loop iterative learning control scheme design",
            "hysteresis input uncertainty",
            "learning convergence",
            "nonlinear systems",
            "composite energy function",
            "dual-loop iterative learning control",
            "input uncertainty",
            "convergence",
            "nonlinear system",
            "iterative learning control",
            "uncertainty"
        ],
        "authors": [
            {
                "name": "Deqing Huang",
                "org": "Dept. of Electr. & Comput. Eng., Nat. Univ. of Singapore, Singapore, Singapore|c|"
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Jian-Xin Xu",
                "org": ""
            }
        ],
        "venue": "Christchurch",
        "year": 2009
    },
    "GK66Sl5q": {
        "id": "GK66Sl5q",
        "title": "Authors' reply [to comments on \"A composite energy function-based learning control approach for nonlinear systems with time-varying parametric uncertainties\"]",
        "abstract": "For original paper see ibid., vol.47, p.1940-5 (2002); for comment see ibid., vol.48, no.9, p.1671-2 (2003). In that paper, a composite energy function learning control approach was proposed to asymptotically eliminate the mismatch between the desired and actual periodic trajectory of a system. The comment highlighted alleged technical errors, especially in light of the fdadt that the boundedness of the learning estimate has historically been a problematic issue. The authors defend their work, pointing out that learning control needs different designs and requires different conditions when addressing different tasks, and acknowledging some error.",
        "keywords": [
            "Nonlinear control systems",
            "Control systems",
            "Nonlinear systems",
            "Time varying systems",
            "Uncertainty",
            "Automatic control",
            "Robots",
            "Robotics and automation",
            "State estimation",
            "Convergence"
        ],
        "authors": [
            {
                "name": "Jian-Xin Xu",
                "org": "Dept . of Electrical Engineering , National University of Singapore"
            },
            {
                "name": "Ying Tan",
                "org": "Australian Telecommunications cooperative research center , CTE,; Victoria University of Technology"
            }
        ],
        "venue": "IEEE Transactions on Automatic Control",
        "year": 2003
    },
    "cgOpadhJ": {
        "id": "cgOpadhJ",
        "title": "Linear and Nonlinear Iterative Learning Control (Lecture Notes in Control and Information Sciences, 291)",
        "abstract": "",
        "keywords": [
            "Information Sciences",
            "Nonlinear Iterative Learning Control",
            "Lecture Notes"
        ],
        "authors": [
            {
                "name": "Jian-Xin Xu",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            }
        ],
        "venue": "Linear and Nonlinear Iterative Learning Control (Lecture Notes in Control and Information Sciences, 291)",
        "year": 2003
    },
    "uKg2a7ZW": {
        "id": "uKg2a7ZW",
        "title": "Nonlinear adaptive wavelet control using constructive wavelet networks.",
        "abstract": "In this paper, an adaptive wavelet-network-based control approach is proposed for highly nonlinear uncertain dynamical systems. Wavelet network, as a kind of universal approximator, has two novel properties--orthonormality and multiresolution. The orthonormal property ensures that adding a new resolution (new wavelets) does not affect the existing wavelet network that may have been well tuned. In the sequel, the online adjustment of the structure of the nonlinear adaptive wavelet controller (AWC) can be done in a constructive manner by gradually increasing the network resolution. The multiresolution property, on the other hand, assures a guaranteed improvement of the approximation precision when a new resolution is added. In real life problems we are unable to know the adequate size of a network, either a neural network (NN) or a wavelet network, to produce the required approximation precision. By virtue of the novel wavelet network properties, a coarse or very simple structure can be selected first. If the system fails to converge after the elapse of a dwell time, a new wavelet resolution is considered to be necessary and added directly. In this manner, the AWC can be easily constructed and tuned from the coarse to finer levels until the performance requirement is satisfied. The trial and error way of selecting the network structure, which may lead to either an inadequate or a highly redundant structure, can be avoided. In this paper, the proposed adaptive wavelet network is applied first to a class of nonlinear dynamical systems with a partially known model and an affine-in-input structure. Then, the adaptive wavelet network is applied to a class of nonlinear nonaffine dynamical systems.",
        "keywords": [
            "neural network",
            "existing wavelet network",
            "wavelet network",
            "uncertain systems",
            "nonlinear adaptive wavelet control",
            "novel wavelet network property",
            "neurocontrollers",
            "new resolution",
            "multiresolution",
            "wavelet transforms",
            "network structure",
            "constructive wavelet networks",
            "new wavelet",
            "adaptive wavelet network",
            "nonlinear dynamical systems",
            "network resolution",
            "multiresolution property",
            "adaptive control",
            "nonlinear control systems",
            "orthonormality",
            "nonlinear uncertain dynamical systems",
            "proposed adaptive wavelet network",
            "nonlinear nonaffine dynamical systems",
            "online structural tuning",
            "orthonormal property",
            "function approximation",
            "degree of freedom",
            "dynamic system",
            "tracking error",
            "convergence rate",
            "error correction",
            "control systems",
            "convergence",
            "neural networks"
        ],
        "authors": [
            {
                "name": "Jian-Xin Xu",
                "org": "Dept. of Electr. & Comput. Eng., Nat. Univ. of Singapore"
            },
            {
                "name": "Ying Tan",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Neural Networks",
        "year": 2007
    },
    "x9XDyTCR": {
        "id": "x9XDyTCR",
        "title": "A composite energy function-based learning control approach for nonlinear systems with time-varying parametric uncertainties",
        "abstract": "A new learning control approach is developed in this note to address a class of nonlinear systems with time-varying parametric uncertainties. The concept of composite energy function (CEF), which provides the system information along both time and learning repetition horizons, is introduced in the analysis of learning control. CEF consists of two parts. The first part is a standard Lyapunov function,. which is used to access system behavior along time horizon during each learning cycle. The second part is an L2 norm of parametric learning errors which reflects the variation of the system status when the control system is updated on the basis of learning cycles. The proposed learning control algorithm achieves asymptotical convergence along a learning repetition horizon. At the same time, the boundedness and pointwise convergence of the tracking error along time horizon is guaranteed. The proposed learning control strategy is applicable to quite general classes of nonlinear systems without requiring the global Lipschitz continuity condition and zero relative degree condition.",
        "keywords": [
            "Nonlinear control systems",
            "Control systems",
            "Nonlinear systems",
            "Time varying systems",
            "Uncertainty",
            "Convergence",
            "Control system analysis",
            "Information analysis",
            "Lyapunov method",
            "Error correction"
        ],
        "authors": [
            {
                "name": "Jian-Xin Xu",
                "org": "Dept . of Electrical Engineering , National University of Singapore"
            },
            {
                "name": "Ying Tan",
                "org": "Australian Telecommunications cooperative research center , CTE,; Victoria University of Technology"
            }
        ],
        "venue": "IEEE Trans. Automat. Contr.",
        "year": 2002
    },
    "HyyYgFbq": {
        "id": "HyyYgFbq",
        "title": "Simultaneous determination of lutein,\u03b1-caroten and \u03b2-carotene levels in foods for infants and young children and milk products by HPLC",
        "abstract": "Objective:A method for simultaneous determination of lutein,\u03b1-carotene and \u03b2-carotene levels in powdered milk by HPLC was developed.Methods: The homogenized samples were saponified and then extracted with petroleum ether and diethyl ether followed by wash and concentration.The mobile phase was methanol-acetonitrile mixture containing 2% water and methyl-t-butyl-ether.Carotenoids were separated by a C30 column and detected with diode array detector.An external standard method was used for quantification.Results: The linearities for three carotenoids were good at concentration ranges of 0.05 \u03bcg/ml~4 \u03bcg/ml,the correlation coefficients were greater than 0.998.The average spiked recoveries for three addition levels were from 80% to 104%.The relative standard deviation of each spiked test was less than 7.7%.Conclusion: The method can simultaneously determine lutein,\u03b1-carotene and \u03b2-carotene levels in powdered milk with simpleness,speediness and accuracy.",
        "keywords": [
            "Milk powder",
            "HPLC",
            "Lutein",
            "Carotenoids"
        ],
        "authors": [
            {
                "name": "HUANG Bai-fen",
                "org": "Zhejiang Provincial Center for Disease Prevention and Control,Hangzhou ,China"
            },
            {
                "name": "ZHENG Kai",
                "org": "Chemical Science and Engineering College of Yunnan University,Kunming ,China"
            },
            {
                "name": "TAN Ying",
                "org": "Zhejiang Provincial Center for Disease Prevention and Control,Hangzhou ,China"
            },
            {
                "name": "REN Yi-ping",
                "org": "Zhejiang Provincial Center for Disease Prevention and Control,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Health Laboratory Technology",
        "year": 2012
    },
    "4kfVCuF2": {
        "id": "4kfVCuF2",
        "title": "A method for fast determination of vitamin A in blood plasma by high performance liquid chromatography",
        "abstract": "Objective:To establish a method for fast determination of vitamin A in blood plasma by high performance liquid chromatography(HPLC).Methods: Under dark condition,the plasma was shaked after adding internal standard,and centrifuged after extraction by n-hexane,then the supernatant was dried by N2 flow,dissolved wtih ethyl alcohol,and finally determined with HPLC.Results: The method had a good linearity with r=0.9998 at the concentration range of 0.034 \u03bcg/ml~0.68 \u03bcg/ml.The recoveries were between 88.2% and 111.8%.The limit of detection was 0.6 ng.Conclusion: The method was simple,fast and accurate,which can satisfy the routine heavy tasks.",
        "keywords": [
            "High performance liquid chromatography",
            "Plasma",
            "Vitamin A"
        ],
        "authors": [
            {
                "name": "ZHOU Ya-qing",
                "org": "Ninghai County Maternal and Child Health Hospital,Ningbo ,China"
            },
            {
                "name": "WANG Tian-jiao",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "TAN Ying",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Health Laboratory Technology",
        "year": 2012
    },
    "WXvk2RWw": {
        "id": "WXvk2RWw",
        "title": "Determination of formaldehyde in food with HPLC",
        "abstract": "Objective:To establish an HPLC method for quantitation of formaldehyde in food.Methods: Samples were leached with water and centrifugalized,then the formaldehyde in upper centrifugate was derivatized with 2,4-dinitrophenylhydrazine(DNPH) and determined by HPLC with external standard calibration method.Results: This HPLC method exhibited a linear relation within 0.21 \u03bcg/ml~104 \u03bcg/ml formaldehyde content(r=0.9998).The minimum detectable limit of this method was 0.20 mg/kg.Furthermore,the recoveries of formaldehyde were 83.2%~115% while the contents of added standard were 1.0 mg/kg~50 mg/kg.Conclusion: This is a simple,accurate and reliable HPLC method for determination of formaldehyde in food.But the values of formaldehyde in food are lacked.We should collect these values as soon as fast.",
        "keywords": [
            "HPLC",
            "Food",
            "Formaldehyde"
        ],
        "authors": [
            {
                "name": "TAN Ying",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "NI Zhu-nan",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "ZHANG J",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "WU Ping-gu",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Health Laboratory Technology",
        "year": 2011
    },
    "6gvkhRkH": {
        "id": "6gvkhRkH",
        "title": "Formation of ethyl carbamate and changes during fermentation and storage of yellow rice wine.",
        "abstract": "Ethyl carbamate (EC) was analyzed during yellow rice wine production and storage. EC increased slowly during fermentation and rapidly after frying and sterilization. Less amount of EC was formed when cooled rapidly to 30 \u00b0C than when cooled naturally. High temperature and long storage time increased EC formation. After 400 days storage, EC increased from 74.0 to 84.2, 131.8 and 509.4 \u03bcg/kg at 4 \u00b0C, room temperature and 37 \u00b0C, respectively, and there was significantly difference between the fried wine and the wine on sale from 2011 (p<0.01). Urea increased during yellow rice wine fermentation and was above 20 mg/kg after the wine was fried; urea contributed to EC formation when the fried wine was cooled slowly. These results indicate that it is necessary for industry to optimize the wine frying conditions, such as temperature, time and cooling process in order to decrease EC formation.",
        "keywords": [
            "change",
            "ethyl carbamate",
            "fermentation",
            "storage",
            "urea",
            "yellow rice wine"
        ],
        "authors": [
            {
                "name": "Pinggu Wu",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention, No. 630 Xincheng Road, Hangzhou 310051, China."
            },
            {
                "name": "Chenggang Cai",
                "org": "College of Biology and Environmental Engineering, Zhejiang Shuren University, No. 8 Shuren Street, Hangzhou 310015, China."
            },
            {
                "name": "Xianghong Shen",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention, No. 630 Xincheng Road, Hangzhou 310051, China."
            },
            {
                "name": "Liyuan Wang",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention, No. 630 Xincheng Road, Hangzhou 310051, China."
            },
            {
                "name": "Jing Zhang",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention, No. 630 Xincheng Road, Hangzhou 310051, China."
            },
            {
                "name": "Ying Tan",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention, No. 630 Xincheng Road, Hangzhou 310051, China."
            },
            {
                "name": "Wei Jiang",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention, No. 630 Xincheng Road, Hangzhou 310051, China."
            },
            {
                "name": "Xiaodong Pan",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention, No. 630 Xincheng Road, Hangzhou 310051, China."
            }
        ],
        "venue": "Food chemistry",
        "year": 2014
    },
    "E1vNtbeq": {
        "id": "E1vNtbeq",
        "title": "Simultaneous determination of 17 phthalate esters in edible vegetable oils by GC-MS with silica/PSA-mixed solid-phase extraction.",
        "abstract": "A quantified method for the determination of 17 phthalate esters (PAEs) in edible vegetable oil by GC-MS with the pretreatment of acetonitrile extraction and silica/N-(n-Propyl)ethylenediamine-mixed SPE column was established. By the quantification of internal standard of D(4)-di(2-ethylhexyl) phthalate, a good linearity range of related 17 PAEs was observed. The correlation coefficient was ranged at 0.994~1.000, and the standard lowest quantified level was 0.05~0.15 mg/L. The spiking recoveries of 17 PAEs were 78.3~108.9% with the relative standard deviations of 4.3~12.1% (n = 6). The method detection limits were 0.1~0.2 mg/kg. Meanwhile, PAEs were determined in 30 plastic buckets of edible vegetable oil from supermarkets in Hangzhou city of China. The survey of 30 oil samples showed di(2-ethylhexyl) phthalate (DEHP) had the 100% (30/30) detection rate. The levels of diisobutyl phthalate with 86.7% (26:30), di-n-butyl phthalate (DBP) with 70% (21:30) and diethyl phthalate with 10% (3:30) were detected. It was worth note that DBP with 16.7% (5:30) samples and DEHP with 10% (3:30) samples were beyond the regular migrating limit, which indicated that more attention should be paid to the PAEs in oil with plastic package.",
        "keywords": [
            "spe"
        ],
        "authors": [
            {
                "name": "PingGu Wu",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China."
            },
            {
                "name": "DaJin Yang",
                "org": ""
            },
            {
                "name": "Liqun Zhang",
                "org": ""
            },
            {
                "name": "XiangHong Shen",
                "org": ""
            },
            {
                "name": "XiaoDong Pan",
                "org": ""
            },
            {
                "name": "LiYuan Wang",
                "org": ""
            },
            {
                "name": "Jing Zhang",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Liang Feng",
                "org": ""
            },
            {
                "name": "Ying Ying",
                "org": ""
            }
        ],
        "venue": "Journal of separation science",
        "year": 2012
    },
    "yw3r9tV4": {
        "id": "yw3r9tV4",
        "title": "Simultaneous determination of ethyl carbamate and 4-(5-)methylimidazole in yellow rice wine and soy sauce by gas chromatography with mass spectrometry.",
        "abstract": "We developed a new method, based on alkaline diatomite solid-phase extraction followed by gas chromatography with mass spectrometry, for the simultaneous determination of the toxic contaminants ethyl carbamate (EC) and 4-(5-)methylimidazole (4-MEI) in yellow rice wine and soy sauce. The optimal extraction conditions were defined. With the application of alkaline diatomite solid-phase extraction, damage to the capillary column by organic acids was greatly reduced. With deuterated EC used as the internal standard, the linearity of the calibration curves for EC and 4-MEI was good with correlation coefficient above 0.99. In a spiked experiment with EC and 4-MEI in yellow rice wine and soy sauce, recovery of the added EC was 80.5-102.5% and that of 4-MEI was 78.3-92.8%. The limit of quantification and limit of detection for EC were 6.0 and 2.0 \u03bcg/kg, respectively, and for 4-MEI were 15.0 and 5.0 \u03bcg/kg, respectively. The validation results demonstrate that the method is fast, simple, and selective, and therefore is suitable for simultaneously determining the presence of EC and 4-MEI in fermented food.",
        "keywords": [
            "ethyl carbamate",
            "gas chromatography with mass spectrometry",
            "methylimidazole",
            "soy sauce",
            "yellow rice wine"
        ],
        "authors": [
            {
                "name": "Pinggu Wu",
                "org": "Center for Disease Control and Prevention of Zhejiang Province, Hangzhou, P. R. China."
            },
            {
                "name": "Liqun Zhang",
                "org": ""
            },
            {
                "name": "Liyuan Wang",
                "org": ""
            },
            {
                "name": "Jing Zhang",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Jun Tang",
                "org": ""
            },
            {
                "name": "Bingjie Ma",
                "org": ""
            },
            {
                "name": "Xiaodong Pan",
                "org": ""
            },
            {
                "name": "Wei Jiang",
                "org": ""
            }
        ],
        "venue": "Journal of separation science",
        "year": 2014
    },
    "SxFrT8Hm": {
        "id": "SxFrT8Hm",
        "title": "Detection of methyl carbamate and ethyl carbamate in yellow rice wine by gas chromatography-mass spectrometry]",
        "abstract": "To establish the method of simultaneous determination of methylcarbamate (MC) and ethylcarbamate (EC) in yellow rice wine by gas chromatography-mass spectrometry (GC/MS).MC and EC in yellow rice wine were derived by 9-xanthydrol, and then the derivants were detected by GC/MS; and quantitatively analyzed by D5-EC isotope internal standard method.The linearity of MC and EC ranged from 2.0 \u00b5g/L to 400.0 \u00b5g/L, with correlation coefficients at 0.998 and 0.999, respectively. The limits of quantitation (LOQ) and detection (LOD) were 0.67 and 2.0 \u00b5g/kg. When MC and EC were added in yellow rice wine at the range of 2.0-300.0 \u00b5g/kg, the intraday average recovery rate was 78.8%-102.3%, relative standard deviation was 3.2%-11.6%; interday average recovery rate was 75.4%-101.3%, relative standard deviation was 3.8%-13.4%. 20 samples of yellow rice wine from supermarket were detected using this method, the contents of MC were in the range of ND (no detected) to 1.2 \u00b5g/kg, the detection rate was 6% (3/20), the contents of EC in the range of 18.6 \u00b5g/kg to 432.3 \u00b5g/kg, with the average level at 135.2 \u00b5g/kg.The method is simple, rapid and useful for simultaneous determination of MC and EC in yellow rice wine.",
        "keywords": [],
        "authors": [
            {
                "name": "Ping-gu Wu",
                "org": "Department of Food Inspection, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China. Email: pgwu@cdc.zj.cn."
            },
            {
                "name": "Bing-jie Ma",
                "org": "Department of Food Inspection, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China."
            },
            {
                "name": "Li-yuan Wang",
                "org": "Department of Food Inspection, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China."
            },
            {
                "name": "Xiang-hong Shen",
                "org": "Department of Food Inspection, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China."
            },
            {
                "name": "Jing Zhang",
                "org": "Department of Food Inspection, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China."
            },
            {
                "name": "Ying Tan",
                "org": "Department of Food Inspection, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China."
            },
            {
                "name": "Wei Jiang",
                "org": "Department of Food Inspection, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China."
            }
        ],
        "venue": "Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]",
        "year": 2013
    },
    "zj89TRev": {
        "id": "zj89TRev",
        "title": "ANALYSIS OF FOUR TOCOPHEROL ISOMERS IN COMMONLY USED EDIBLE VEGETABLE OILS IN ZHEJIANG PROVINCE",
        "abstract": "Objective To determine the content of four tocopherol isomers in commonly used edible vegetable oils in Zhejiang province,and estimate the vitamin E dietary intakes from different edible oils in residents.Method High performance liquid normal phase chromatography was used.The mobile phase was hexane and methyl-t-butyl-ether(90:10,v/v).Tocopherol isomers were separated by the SunFire Silica column(4.6 mm\u00d7250 mm,5 m)and detected in fluorescence detector with excitation wavelength of 294 nm and emission wavelength of 328 nm.The contents of four tocopherol isomers were detected in 10 varieties of edible vegetable oils in 120 replicates commercially available in Zhejiang Province.We used recommended fat intake from Chinese Dietary Reference Intakes(DRI,2000 version) and data from the health status report in Zhejiang Province for reference and estimated the residents' daily intake of vitamin E from dietary edible oils.Results Baseline separation was achieved in determination of chemical structures of four tocopherol isomers.Then four isomers of tocopherols were identified in all edible vegetable oils while the contents were significantly different.The highest total tocopherols content was 949 mg/kg in soybean oil.The highest effective total tocopherol(alpha-TE) was 362 mg/kg in the sunflower oil.Soybean oil and other 6 vegetable oils had similar \u03b1-TE content between 150-190 mg/kg,slightly lower in rice bran oil and olive oil between 80 to 120 mg/kg.The vitamin E intake in Zhejiang Province was estimated to be 2.4 to 10.9 mg daily from dietary oils,17%-78% of DRI of vitamin E.Conclusions Vitamin E is abundant in vegetable oils.The vitamin E intake was significantly different when different vegetable oils were comsumed.",
        "keywords": [
            "vegetable oil",
            "vitamin E(VE)",
            "dietary intake",
            "analytical method"
        ],
        "authors": [
            {
                "name": "HUANG Bai-fen",
                "org": ""
            },
            {
                "name": "TAN Ying",
                "org": ""
            },
            {
                "name": "YAO Jian-hua",
                "org": ""
            },
            {
                "name": "ZHENG Fei-fei",
                "org": ""
            },
            {
                "name": "REN Yi-ping",
                "org": ""
            }
        ],
        "venue": "Acta Nutrimenta Sinica",
        "year": 2013
    },
    "ZEQ41RLY": {
        "id": "ZEQ41RLY",
        "title": "Determination of adenosine in Huaweixian capsule",
        "abstract": "Objective:To establish an HPLC method for quantitation of adenosine in Huaweixian capsule.Methods:Select the best extract solvent from severe candidates according to determined added standard recoveries and content of adenosine.Then do the HPLC methodology demonstration using selected best extract solvent.Results:The method using purified water as extract solvent exhibited a linear relation within 0.84~66.96 \u03bcg/ml adenosine content.The regression equation was Y=68700X-18500(r=0.9999) and the minimum detectable limit of this method was 0.02 mg/100 g.Furthermore,the recoveries of adenosine were 95.9%~102.1% while the contents of added standard were 8.37~41.85 mg/100 g.Conclusion:This method using purified water as extract solvent is simple,accurate and reliable for determination of Adenosine in Huaweixian capsule.",
        "keywords": [
            "HPLC",
            "Huaweixian capsule",
            "Extract solvent",
            "Adenosine"
        ],
        "authors": [
            {
                "name": "Tan Ying",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "Han Jian-long",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "Zhang Jing",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "Feng Liang",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "Cai Zeng-xuan",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "Ren Yi-ping",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Health Laboratory Technology",
        "year": 2007
    },
    "HngJO2no": {
        "id": "HngJO2no",
        "title": "Determination of rac-1-lauroylglycerol in food by GC-FID",
        "abstract": "Objective:To establish a method for rac-1-lauroylglycerol determination in food by gas chromatography-flame ionization detector(GC-FID).Methods: The rac-1-lauroylglycerol in food was saponified,and derived with boron trichloride,then direct extracted with n-hexane,finally analyzed by gas chromatography-flame ionization detector(GC-FID).Results: The detection limit of the method was 2.28 ng with the recoveries of 88.56%\uff5e97.95% when spiked concentration was from 5.07 to 25.35 mg/kg,RSD was 8.23%,and the linearity range of this method was from 10.14 to 1014.00 \u03bcg/ml with correlation,coefficient of 0.9999.Conclusion: The method was easy to operate and accurate.It can be used for determination of rac-1-lauroylglycerol in food samples.",
        "keywords": [
            "Rac-1-lauroylglycerol",
            "Gas chromatography",
            "Food"
        ],
        "authors": [
            {
                "name": "ZHANG Jing",
                "org": "Zhejiang Province Center for Disease Control & Prevention,Hangzhou ,China"
            },
            {
                "name": "TANG Jun",
                "org": "Zhejiang Province Center for Disease Control & Prevention,Hangzhou ,China"
            },
            {
                "name": "TAN Ying",
                "org": "Zhejiang Province Center for Disease Control & Prevention,Hangzhou ,China"
            },
            {
                "name": "MA Bing-jie",
                "org": "Zhejiang Province Center for Disease Control & Prevention,Hangzhou ,China"
            },
            {
                "name": "NI Zhu-nan",
                "org": "Zhejiang Province Center for Disease Control & Prevention,Hangzhou ,China"
            },
            {
                "name": "REN Yi-ping",
                "org": "Zhejiang Province Center for Disease Control & Prevention,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Health Laboratory Technology",
        "year": 2010
    },
    "mH03b9Mc": {
        "id": "mH03b9Mc",
        "title": "Determination of basic orange in capsicum by HPLC",
        "abstract": "Objective:To establish an HPLC method for quantitation of basic orange in capsicum.Methods:Selecting the best chromatograph conditions to determine the concentration of basic orange in capsicum and the added standard recoveries of it.Then do the HPLC methodology demonstration using the selected chromatograph conditions.Results:This HPLC method exhibited a linear relation within 0.40~100.00 \u03bcg/ml basic orange content.The regression equation was y=3.80e+004x+6.09+003(r2=0.9999) and the minimum detectable limit of this method was 0.32 mg/L.Furthermore,the recoveries of basic orange were 91.5%~108.5% while the contents of added standard were 0.40~30.00 mg/kg.Conclusion:This is a simple,accurate and reliable HPLC method for determination of basic orange in capsicum.",
        "keywords": [
            "HPLC",
            "Basic orange",
            "Capsicum"
        ],
        "authors": [
            {
                "name": "TAN Ying",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "WU Ping-gu",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "ZHANG Jing",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "CAI Zeng-xuan",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "PAN Xiao-dong",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "HAN Jian-long",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Health Laboratory Technology",
        "year": 2010
    },
    "4obEgyDU": {
        "id": "4obEgyDU",
        "title": "Research on determination of thiocyanate in dairy products by ion chromatography-conductivity detection",
        "abstract": "Objective To establish a method for determination of thiocyanate in dairy products by ion chromatography.Methods The dairy product samples were treated with glacial acetic acid solution to precipitate and filtrate protein and defatted on C18SPE column.Then the samples were directly analyzed by ion chromatograph.Chromatographic separation was carried out on Ionpac AS19 column( 250mm \u00d7 4mm i.d.,5\u03bcm) with ASRS-ULTRA\u2161 anion suppressor,and a DS6 suppressed conductivity detector was used for the determination,and the eluent was adjusted to contain 40 mmol / L hydroxyl ions.The external standard method was used for thiocyanate quantification.Results The linear range was 0.5 \u03bcg /ml \uff5e 5.0 \u03bcg /ml for thiocyanate with correlation coefficients more than 0.999.When the signal to noise ratio equals to 3,the limit of quantitation was found to be 0.2 mg / L.Conclusion The developed method was satisfying with the determination of thiocyanate in dairy products.",
        "keywords": [
            "Ion chromatography",
            "Dairy products",
            "Thiocyanate"
        ],
        "authors": [
            {
                "name": "NI Zhu-nan",
                "org": ""
            },
            {
                "name": "TAN Ying",
                "org": ""
            },
            {
                "name": "WU Ping-gu",
                "org": ""
            }
        ],
        "venue": "Chinese Journal of Health Laboratory Technology",
        "year": 2013
    },
    "v2gP03j1": {
        "id": "v2gP03j1",
        "title": "The comparison of different extraction methods of methylmercury in fish tissue",
        "abstract": "Objective:To compare the extraction recovery of methylmercury using the different methods,and obtain the optimized extraction conditions.Methods: Methylmercury in the standard reference materials of fish tissue was extracted by the water bath,ultrasonic and microwave extraction with 5 mol/L HCl,acetic acid,25% NaOH and tetramethylammonium(TMAH) were used as extraction solvent respectively and finally determined by LC-HG-AFS.Results: The optimal extraction time for water bath,ultrasonic and microwave extraction were 12 hrs,4 hrs and 10 min,respectively.Both selected acid and alkali can be used as the extraction solutions,and the acids extraction obtained the maxim recovery rate.Conclusion: The three methods were all qualified for the methylmercury extraction,but microwave extraction is recommended for time-saving.",
        "keywords": [
            "Extraction method",
            "Methylmercury",
            "Fish tissue",
            "LC-AFS"
        ],
        "authors": [
            {
                "name": "PAN Xiao-Dong",
                "org": "Zhejiang Provincial Center For Disease Control And Prevention,Hangzhou ,China"
            },
            {
                "name": "MA Bing-Jie",
                "org": "Zhejiang Provincial Center For Disease Control And Prevention,Hangzhou ,China"
            },
            {
                "name": "TAN Ying",
                "org": "Zhejiang Provincial Center For Disease Control And Prevention,Hangzhou ,China"
            },
            {
                "name": "WU Ping-Gu",
                "org": "Zhejiang Provincial Center For Disease Control And Prevention,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Health Laboratory Technology",
        "year": 2011
    },
    "JNMIYjTI": {
        "id": "JNMIYjTI",
        "title": "Determination 12 kinds of Preservatives in Cosmetics simultaneously by HPLC",
        "abstract": "Objective:To develop a HPLC method for determination of preservatives.Methods: After ultrasonic extraction in methanol,samples were analyzed by HPLC.With acetonitrile as mobile phase A,0.05 mol/L sodium dihydrogen phosphate solution(pH=3.0) as mobile phase B gradient elution,flow rate 1 ml/min.Detection wavelength of 265 nm.Results: In a given within the concentration range of the peak area and concentration of preservatives has a good linear relationship.To add a certain concentration of preservatives standard measured by the average recovery was 87.4%~139%,relative standard deviation is 0.16%~5.81%(n=6).Conclusion: This method can simultaneously determine 12 kinds of preservatives.Separation effect is good. The method is simple,fast,high accuracy and good reproducibility.It can be used for simultaneous detection of multiple preservatives.",
        "keywords": [
            "HPLC",
            "Cosmetic",
            "Preservatives"
        ],
        "authors": [
            {
                "name": "FENG Liang",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "YING Ying",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "TAN Ying",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "ZHANG Nian-hua",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "MA Bing-jie",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "ZHAO Yong-xin",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Health Laboratory Technology",
        "year": 2010
    },
    "SA8Q1LxC": {
        "id": "SA8Q1LxC",
        "title": "The determination of phthalic acid esters in edible vegetable oils by gas chromatography-mass spectrometry]",
        "abstract": "We aimed to establish a quantified method for the 17 phthalate acid esters (PAE) in edible vegetable oil by gas chromatography-mass spectrometry (GC-MS) with the pretreatment of acetonitrile extraction and silica/N-(n-propyl)ethylenediamine (silica/PSA) mixed solid phase extraction column and evaluated the PAE of 25 edible oil samples from supermarkets in Hangzhou city.The internal standard solution (D4-DEHP) was added in edible vegetable oil sample. The analytes were extracted by acetonitrile with 1 min vortex, and centrifuged at 3050\u00d7g for 5 min. The supernatant was then cleaned with silica/PSA column, and eluted with acetonitrile. The elution was dried with N2 flow at 50\u00b0C and diluted to 1.0 ml with hexane. Then, 17 PAE were tested by GC-MS and quantified with internal standards. The repeatability and sensitivity of the assay were evaluated. PAE were then determined in 25 plastic buckets of edible vegetable oil from supermarkets in Hangzhou city.By the quantification of internal standard of D4-DEHP, a good linearity range of related 17 PAE was observed. The correlation coefficient was 0.994-1.000 and the standard lowest quantified level was 0.05-0.15 \u00b5g/ml. The spiking recoveries of 17 PAE were 78.3%-108.9% with the RSD of 4.3%-12.1% (n=6). The method detection limits were 0.1-0.2 mg/kg. In 25 plastic buckets of edible vegetable oil from Hangzhou, DMP, DEP, DIBP, DBP and DEHP were detected at the range of <0.1-1.8 mg/kg and the detection rates were 12% (3/25), 24% (6/25), 100% (25/25), 96% (24/25) and 100% (25/25), respectively. Other 12 PAE was not detected. For DBP with the level of <0.1 to 1.3 mg/kg, the results of 16% (4/25) samples exceeded the regular migrating limit of 0.3 mg/kg. For DEHP of <0.2-1.8 mg/kg, the data of 12% (3/25) samples were beyond the regular migrating limit of 1.5 mg/kg.The pretreatment by silica/PSA mixed solid phase extraction column can satisfy the PAE determination requirements in edible vegetable oils. The DMP, DIBP, DEP, DBP and DEHP were detected from the survey of 25 edible oil samples in Hangzhou city.",
        "keywords": [],
        "authors": [
            {
                "name": "Ping-gu Wu",
                "org": "Institute of Physical and Chemical Inspection, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China. pgwu@cdc.zj.com"
            },
            {
                "name": "Da-jin Yang",
                "org": ""
            },
            {
                "name": "Xiang-hong Shen",
                "org": ""
            },
            {
                "name": "Xiao-dong Pan",
                "org": ""
            },
            {
                "name": "Li-yuan Wang",
                "org": ""
            },
            {
                "name": "Jing Zhang",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Liang Feng",
                "org": ""
            },
            {
                "name": "Ying Ying",
                "org": ""
            }
        ],
        "venue": "Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]",
        "year": 2012
    },
    "C38fppn2": {
        "id": "C38fppn2",
        "title": "Simultaneous determination of sulfonamide residues in chicken muscle by solid phase extraction and high performance liquid chromatography",
        "abstract": "Objective:To establish an HPLC method for quantization of 10 sulfonamides residues in chicken muscle.Methods:Chicken muscle was extracted with methanol,defatted with n-hexane and cleaned up with SLW solid-phase extraction.Then the concentration of 10 sulfonamides residues was determined by HPLC.Results:The recoveries of 10 sulfonamides residues in chicken muscle were 67.4%~95.6%,with relative standard deviations between 4.8% and 11.5%.While the contents of added standard were 0.05~0.2 mg/kg.and the minimum detected limits of this method were 0.01 mg/kg.Conclusion:This is a simple,accurate and reliable method for determination of 10 sulfonamides residues in chicken muscle.",
        "keywords": [
            "HPLC",
            "Determination",
            "Solid phase extraction",
            "Sulfonamides",
            "Residue"
        ],
        "authors": [
            {
                "name": "Wu Ping-gu",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "Wang Qiang",
                "org": "Zhejiang Agricultural Scientific Academy,Hangzhou ,China"
            },
            {
                "name": "Zhao Yong-xin",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "Tan Ying",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "Ying Ying",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Health Laboratory Technology",
        "year": 2008
    },
    "GYPh4alS": {
        "id": "GYPh4alS",
        "title": "Simultaneous determination of nineteen \u03b2-lactam residues in milk by ultra performance liquid chromatography-electrospray tandem mass spectrometry",
        "abstract": "Objective:A ultra performance liquid chromatography-mass spectrometric(UPLC-ESI-MS/MS) method for the determination of Nineteen \u03b2-lactam residues(12 Penicillins of Amoxicillin,Ampicillin,Methicillin,Piperacillin,Penicillin G,Methicillin,Penicillin V,Phenethicillin,Oxacillin,Dicloxacillin,Cloxacillin,Nafcillin and 7 Cephalosporins of Cefapirin,Cefalexin,Cefradine,Cefoperazone,Ceftiofur,Cefalothin) in milk was reported.Methods:Using PenicillinG-D7 as internal standard to improve the influence effectiveness by sample stroma.Samples were prepared by depositing protein,centrifugation,SPE column purification.The separation was performed on a Waters ACQUITY UPLCTM BEH SHELD RP18(100 mm x 1.0 mm,dp 1.7 \u03bcm)with gradient elution using acetonitrile and water(containing 0.1% formic acid)at a flow rate of 0.3 ml/min.19 \u03b2-lactams were separated in 12 min.The parameters of MS/MS were optimized under the mode of MRM and two daughter ions were chosen for each \u03b2-lactam with one as quantification ion while the other as assistant qualification ion.Results:The LOD range of 19 \u03b2-lactams was 0.01\uff5e0.3 \u03bcg/L,the LOD range was 0.034\uff5e1.144 \u03bcg/L,correlation coefficients(r) were >0.99 in the range of 0.01\uff5e200 \u03bcg/L.Average recoveries for the 19 \u03b2-lactams spiked at the levels of low,medium and high concentrations(2.5,5.0,7.5 \u03bcg/L) of 73.4%\uff5e112.7%,75.7%\uff5e103.1%,80.0%\uff5e103.6%,with relative standard deviations of 4.3%\uff5e17.4%,2.9%\uff5e15.2%,1.8%\uff5e9.2%.Conclusion:The method is fast,sensitive and specific for the determination of glucocorticoids residues in milk.",
        "keywords": [
            "Milk",
            "Determination",
            "\u03b2-lactams",
            "LC-MS/MS",
            "Residue"
        ],
        "authors": [
            {
                "name": "HUANG Bai-fen",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "WU Dan-qing",
                "org": "Huzhou Center for Disease Control and Prevention,Huzhou ,China"
            },
            {
                "name": "CAI Zeng-xuan",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "TAN Ying",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "REN Yi-ping",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Health Laboratory Technology",
        "year": 2010
    },
    "5n16mGPF": {
        "id": "5n16mGPF",
        "title": "Rapid determination of biogenic amines in beer and juice by high performance liquid chromatography",
        "abstract": "Objective To establish an HPLC method for determination of biogenic amines(histamine,tyramine,putrescine,cadaverine,spermine,spermidine,tryptamine and phenethylamine) in beer and juice.Methods The best chromatograph conditions was selected to determine biogenic amines with a pre-column dansyl chloride derivation procedure.1,7-diaminoheptane was used as the internal standard(IS).Biogenic amines were separated by C18 column(250 mm \u00d7 4.6 mm ID,5 \u03bcm)and detected at 254 nm by diode array detector.Results The correlation coefficients of standard curve of the eight kinds of biogenic amines were greater than 0.999.The detection limits were 0.2 mg/kg(histamine was 0.4 mg/kg),the average recovery was 72.57%~104.7%,RSD was 2.51%~5.12%.Conclusion The method was simple,accurate and reliable for the determination of biogenic amines in beer and juice.",
        "keywords": [
            "High-performance liquid chromatography",
            "Beer",
            "Biogenic amines",
            "Juice"
        ],
        "authors": [
            {
                "name": "TAN Ying",
                "org": ""
            },
            {
                "name": "NI Zhu-nan",
                "org": ""
            },
            {
                "name": "JIANG Wei",
                "org": ""
            },
            {
                "name": "ZHU Jian-pan",
                "org": ""
            },
            {
                "name": "WANG Zhi-yuan",
                "org": ""
            },
            {
                "name": "WU Ping-gu",
                "org": ""
            }
        ],
        "venue": "Chinese Journal of Health Laboratory Technology",
        "year": 2013
    },
    "AbIU9N4a": {
        "id": "AbIU9N4a",
        "title": "Determination of boron in flour food by graphite furnace atomic absorption spectroscopy",
        "abstract": "Objective:To establish a method for Determination of Boron in fLour food by graphite furnace atomic absorption spectroscopy.Methods: The Boron in fLour food was detected by ETAAS with Pd coated tube after wasinvestigated.Results: The detection limit of the method was15.4 \u03bcg,the recoveries of 74%\uff5e95% when dopant concentration was from 12.4 \u03bcg/g to 71.4 \u03bcg/g,RSD was1.1%\uff5e9.1%,and the linearity of this methhod was 0.9992.Conclusion: The method of determination of Boron in fLour food by ETAAS was low disturb,easy to operated and accurate.It can be used in research of the Boron in fLour food,especially to be used in the detectation of Borax in foodstuff indirect.",
        "keywords": [
            "FLo\u03bcr food",
            "Graphite f\u03bcrnace atomic absorption spectroscopy",
            "Microwave digestion",
            "Boron"
        ],
        "authors": [
            {
                "name": "WANG Hui-hua",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "JIANG Ming-zhe",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "ZHANG Jing",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "TAN Ying",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "NI Zhu-nan",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Health Laboratory Technology",
        "year": 2010
    },
    "ykLRQWeS": {
        "id": "ykLRQWeS",
        "title": "Speciation of arsenic compounds in plant seafood by atomic fluorescence spectometry",
        "abstract": "Objective:To establish a method for the determination of four arsenic species by the combination of Ion exchange chromatography and hydride generation atomic fluorescence spectrometry.Methods: In this research,an on-line system of HPLC and hydride generation atomic fluorescence spectrometry was used for arsenic speciation.It has realized on-line separation and analysis of four arsenic species(As\u2162,DMA\u2164,MMA\u2164 and As\u2164).Results: Various experimental parameters were optimized.Four arsenic species were separated by PRX-X100 anion exchange column and determined within 12 minutes in optimal conditions.Under the hydride reaction condition of 8%HCl and 2%(m/V)KBH4 with 100 \u03bcl injection volume,the detection limits of various forms were 0.48 \u03bcg/L for As(\u2162),0.56 \u03bcg/L for DMA,0.44 \u03bcg/L for MMA and 0.52 \u03bcg/L for As(V).The precision RSD of various forms was <5%(n=7).The linear relationship was good in the range of 5 \u03bcg/L\uff5e100 \u03bcg/L content of various forms(r>0.9992).Conclusion: This method is simple,convenient,rapid and accurate with high sensitivity and precision.It was suitable for speciation of arsenic compounds in plant seafood",
        "keywords": [
            "Speciation",
            "Atomic fluorescence Spectrometry",
            "Arsenic",
            "Ion exchange chromatography"
        ],
        "authors": [
            {
                "name": "MA Bing-jie",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "YING Ying",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "NI Zhu-nan",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "TAN Ying",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "ZHANG Jing",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Health Laboratory Technology",
        "year": 2010
    },
    "83lIMY4I": {
        "id": "83lIMY4I",
        "title": "Research on residual determination of bromate in flour and flour products by Ion chromatography",
        "abstract": "Objective:To establish a method for residual determination of bromate in flour and its products by ion chromatography.Methods:Bromate was first extracted from the sample by water bath heating and purified by a silver column,then determined by ion chromatography.Chromatographic separation was carried out on Ionpac AS19 column(250 mm\u00d74 mm i.d.,5 \u03bcm) with ASRS-ULTRA\u2161 anion suppressor,and a DS6 suppressed conductivity detector was used to the determination,and potassium hydroxide was used in gradient elution.Results:The linear range was 1.0 \u03bcg/ml\uff5e6.0 \u03bcg/ml for bromate with correlation coefficients of more than 0.999.When the signal to noise ratio equals to 3,the limits of quantitation were found to be 0.1 mg/kg.Conclusion:The developed method was satisfied with the residual determination for bromate in flour and its products.",
        "keywords": [
            "Flour and its products",
            "Ion Chromatography",
            "Bromate"
        ],
        "authors": [
            {
                "name": "NI Zhu-nan",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "ZHANG Nian-hua",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "TAN Ying",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "ZHANG Jing",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Health Laboratory Technology",
        "year": 2011
    },
    "ex5a1gHp": {
        "id": "ex5a1gHp",
        "title": "Determination of four elements in blood by octopole reaction system with inductively coupled plasma mass spectrometry",
        "abstract": "Objective:To establish the method for determination of 4 elements in blood by octopole reaction system with inductively coupled plasma mass spectrometry.Methods: The samples were diluted by 0.1%Triton X-100+0.1%HNO3.The solution was directly analyzed by ORS-ICP-MS for determination of four elements in blood,including Pb,As,Hg,Cd.Results: The detection limit of each element was between 0.20 \u03bcg/L~0.52 \u03bcg/L.Deviations were below 3.0%.Recovery rates were in the range of 94.0%~102%.Standard reference materials were used as quality control standards and the analysis results conformed well to the certified values.Conclusion: The method is simple,rapid,accurate and reliable for determination of four elements in blood samples.",
        "keywords": [
            "Whole blood",
            "Octopole reaction system with inductively coupled plasma mass spectrometry",
            "Direct injection",
            "Element"
        ],
        "authors": [
            {
                "name": "YING Ying",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "TAN Ying",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "MA Bing-jie",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "WANG Li-yuan",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "ZHANG Jing",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Health Laboratory Technology",
        "year": 2011
    },
    "0V2kiFf0": {
        "id": "0V2kiFf0",
        "title": "Simultaneous determination of 25 sex hormones in Cosmeceutical by liquid chromatography tandem mass spectrometry with isotope dilution",
        "abstract": "Objective:A reliable ultra-high performance liquid chromatography\u2013tandem mass spectrometry(UPLC\u2013MS/MS) method for simultaneous determination of 25 sex hormones in Cosmeceutical was developed.Methods: The sample was extracted by methanol or acetonitrile and the extract was purified by HLB solid phase extraction-based clean-up column.Then,the analytes were separated on an ACQUITY UPLC BEH SHELD RP18 column(100\u00d72.1 mm,1.7 \u03bcm),7 female sex hormones gradiently eluted with a mobile phase consisting of water and acetonitrile in 8 min.,18 Androgen,progestogen sex hormones gradiently eluted with a mobile phase consisting of 0.1% formic acid water and acetonitrile-methanol(1+9,V+V)in 20 min.The female sex hormones were detected in negative electro-spray ionization and the Androgen,progestogen sex hormones were detected in positive electro-spray ionization using multiple reaction monitoring mode.Estriol\u2013D3,Estradiol\u2013D3,Diethylstilbestrol\u2013D6,Testosterone\u2013D3,Chlorotestosterone\u2013D3 and Chlormadinone-CL37 were used as the internal standards to reduce the matrix effects.Results: The limit of detection for25 sex hormones in oil,emulsion and water were 1.0 \u03bcg/kg~30.5 \u03bcg/kg\u30010.2 \u03bcg/kg~12.5 \u03bcg/kg\u30010.1 \u03bcg/kg~22.7 \u03bcg/kg.Good linear relationships and high correlation coefficients(R2>0.99) were obtained in the concentration range of 0.1 \u03bcg/ml~2.0 \u03bcg/ml.The average recoveries were 58.6%~108.1%,67.1%~128.4%,68.8%~128.4% at spiked levels of 100 ng,500 ng and 1000 ng,relative standard deviations were\ufe6415%.Finally,a total of 30 samples randomly collected from different supermarkets in Zhejiang province were screened for 25 sex hormones with the proposed method.The results showed that only 1 sample was contaminated with Estradiol.Conclusion: The sample processing method is suitable for any Cosmeceuticals.Routine tests showed that the method is fast,sensitive,simple and accurate.",
        "keywords": [
            "Cosmeceuticals",
            "Liquid chromatography tandem mass spectrometry",
            "Isotope dilution",
            "Sex hormones"
        ],
        "authors": [
            {
                "name": "HUANG Bai-fen",
                "org": "Zhejiang Provincial Center for Disease Prevention and Control,Hangzhou ,China"
            },
            {
                "name": "YE Lei",
                "org": "Zhejiang University City College,Hangzhou ,China"
            },
            {
                "name": "TAN Ying",
                "org": "Zhejiang Provincial Center for Disease Prevention and Control,Hangzhou ,China"
            },
            {
                "name": "WANG Xiao-fang",
                "org": "Hangzhou Center for Disease Control and Prevention,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Health Laboratory Technology",
        "year": 2011
    },
    "mUraJIoU": {
        "id": "mUraJIoU",
        "title": "Determination of adenosine in health food",
        "abstract": "Objective:To establish a HPLC method for quantitation of \u03b1-Lipoic acid in health food.Methods:Select the best chromatograph conditions to determine the concentration of \u03b1-Lipoic acid in health food and the added standard recoveries of it.Then do the HPLC methodology demonstration using the selected chromatograph conditions.Results:This HPLC method exhibited a linear relation within 4.66~466.40 \u03bcg/ml \u03b1-lipoic acid content.The regression equation was Y=6e-05X-5.203(r2=0.9994) and the minimum detectable limit of this method was 0.1 mg/g.Furthermore,the recoveries of \u03b1-Lipoic acid were 91.5%~108.5% while the contents of added standard were 0.47~3.50 mg/g.Conclusion:This is a simple,accurate and reliable HPLC method for determination of \u03b1-Lipoic acid.",
        "keywords": [
            "HPLC",
            "Health food",
            "\u03b1-Lipoic acid"
        ],
        "authors": [
            {
                "name": "Tan Ying",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "Wu Ping-gu",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "Zhang Jing",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "Feng Liang",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "Han Jian-long",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Health Laboratory Technology",
        "year": 2008
    },
    "EFBmBt4o": {
        "id": "EFBmBt4o",
        "title": "Determination of \u03b1-Lipoic acid in cosmetics by HPLC",
        "abstract": "Objective:To establish an HPLC method for quantitation of \u03b1-Lipoic acid in cosmetics.Methods: The best chromatograph conditions were selected to determine the concentration and recoveries of \u03b1-Lipoic acid in cosmetics.Then the HPLC methodology demonstration was done using the selected chromatograph conditions.Results: This HPLC method exhibited a linear relation within 2.032 \u03bcg/ml\uff5e203.2 \u03bcg/ml for \u03b1-Lipoic acid content.The regression equation was y=15190x+72209(R2=0.9998).When \u03b1-Lipoic acid was added into samples at the concentration of 10.16 \u03bcg/ml,20.32 \u03bcg/ml and 40.64 \u03bcg/ml,the average recovery was 91.6%\uff5e107.8%,relative standard deviation was 3.72%\uff5e4.45%(n=6).Conclusion: This is a simple,accurate and reliable method for determination of \u03b1-Lipoic acid in cosmetics.",
        "keywords": [
            "HPLC",
            "\u03b1-Lipoic acid",
            "Cosmetics"
        ],
        "authors": [
            {
                "name": "TAN Ying",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "NI Zhu-nan",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "ZHU Jian-pan",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "ZHAO Yong-xin",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "WU Ping-gu",
                "org": "Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Health Laboratory Technology",
        "year": 2012
    },
    "FXqIdNou": {
        "id": "FXqIdNou",
        "title": "Survey and analysis of ethyl carbamate in commercial fermented foods in Hangzhou in 2010]",
        "abstract": "To observe the ethyl carbamate concentrations in different commercial fermented foods in Hangzhou in 2010.In 2010, 237 commercial fermented food samples of eight categories, including yellow wine, white spirit, wine, beer, cooking wine, sauce, vinegar and fermented bean curd, were purchased from 3 different size markets respectively in Hangzhou. The ethyl carbamate was measured by gas chromatography-mass spectrometry in selection ion mode, after the samples were coupled with D5-ethyl carbamate, and purified by diatomite solid phase extraction column.The results showed that ethyl carbamate was detected in all samples analyzed (100%) with the range from 2.0 \u00b5g/kg to 515.0 \u00b5g/kg. The ethyl carbamate average (median) levels in 8 food categories were descending with fermented red bean curd (182.2 \u00b5g/kg (161.2 \u00b5g/kg)), yellow wine (159.6 \u00b5g/kg (121.0 \u00b5g/kg)), cooking wine (86.8 \u00b5g/kg (95.6 \u00b5g/kg)), white spirit (72.0 \u00b5g/kg (60.5 \u00b5g/kg)), soy sauce (47.2 \u00b5g/kg (40.7\u00b5g/kg)), vinegar (26.7 \u00b5g/kg (31.8 \u00b5g/kg)), wine (15.7 \u00b5g/kg (16.8 \u00b5g/kg)) and beer (2.2 \u00b5g/kg (2.3 \u00b5g/kg)).The ethyl carbamate was detected in all fermented foods in Hangzhou in 2010, and the levels of ethyl carbamate in red bean curd and yellow wine were higher than others.",
        "keywords": [],
        "authors": [
            {
                "name": "Ping-Gu Wu",
                "org": "Zhejiang Provincial Center For Disease Control and Prevention, Hangzhou 310051, China. pgwu@cdc.zj.cn"
            },
            {
                "name": "Da-Jin Yang",
                "org": ""
            },
            {
                "name": "Xiang-Hong Shen",
                "org": ""
            },
            {
                "name": "Li-Yuan Wang",
                "org": ""
            },
            {
                "name": "Xiao-Dong Pan",
                "org": ""
            },
            {
                "name": "Jing Zhang",
                "org": ""
            },
            {
                "name": "Yong-Xin Zhao",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            }
        ],
        "venue": "Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]",
        "year": 2011
    },
    "rGCfsqrw": {
        "id": "rGCfsqrw",
        "title": "Determination of tetrodotoxin in globefish by gas chromatographymass spectrometry",
        "abstract": "Ojbective:A method of gas chromatography-mass spectrometry to determine tetrodotoxin in globefish was established.Methods:Extracted with 2% acetic acid/methanol,defatted using hexane.Then alkaline hydrolysis was performed to change tetrodotoxin into 2-amino-6-hydroxymethyl8-hydroxyquinazoline(C9-base).Further cleanup using C18 cartridge and the purified residue was derivatized with BSTFA,the trimethylsilylated(TMS) C9-base quantitied using scan mode by GC/MS,Quantitied ion was 392.Results:In this way,the rates of recovey of tetrodotoxin were 51.2%\uff5e87.0%.The variation coefficients were 4.7%\uff5e6.6% when spiked with 0.25,1.0,5.0 mg/kg of the tetrodotoxin and the detection limit of tetrodotoxin was 0.05 mg/kg,respectively.Conclusion:The method of tetrodotoxin detection in globefish is simple,sensitive,accurate and it can be satifactorily applied to the sample analysis.",
        "keywords": [
            "Determination",
            "Tetrodotoxin",
            "Gas chromatography-mass spectrometry"
        ],
        "authors": [
            {
                "name": "WU Ping-gu",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "ZHAO Yong-xin",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "SHEN Xiang-hong",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "ZHANG Jing",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "WANG Li-yuan",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "TAN Ying",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "FENG Liang",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Health Laboratory Technology",
        "year": 2009
    },
    "r1N6d01T": {
        "id": "r1N6d01T",
        "title": "Determination of chlolesterol in milk tea by GC-FID",
        "abstract": "Objective:To study a method for cholesterol determination in milk tea by gas chromatography-flame ionization detector(GC-FID).Methods:The cholesterol in milk tea was directly extracted by petroleum ether,and purified by anhydrous sodium sulfate and high speed centrifugation was developed,then detected by gas chromatography-flame ionization detector(GC-FID).Results:The detection limit of the method was 1.5600 ng,the recoveries of 88.89%\uff5e108.70% when dopant concentration was from 5.0 mg/kg to 50.0 mg/kg,RSD was 6.83%.Conclusion:The method of determination of cholesterol in milk tea by GC-FID is low interference,easy to operated and accurate.It can be used in research of the cholesterol in liquid sample.",
        "keywords": [
            "Qualitative analysis",
            "Milk tea",
            "Gas chromatography",
            "Cholesterol"
        ],
        "authors": [
            {
                "name": "Zhang Jing",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "Tang Jun",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "Tan Ying",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "Ma Bing-jie",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "Ni Zhu-nan",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            },
            {
                "name": "Ren Yi-ping",
                "org": "Zhejiang Center for Disease Control and Prevention,Hangzhou ,China"
            }
        ],
        "venue": "Chinese Journal of Health Laboratory Technology",
        "year": 2009
    },
    "w4qnkrmB": {
        "id": "w4qnkrmB",
        "title": "Analysis on Fracture of Gear-shift Shaft of Motorcycles",
        "abstract": "Analysis on macro,metallography,chemistry and fracture appearance were carried out on broken gear-shift shaft in motorbike.The results show that blocks and network of ferrite existed in the base of gear-shift shaft due to improper quenching-and-tempering.It reduces the toughness and intensity of the shaft,that leaded to the torsion fracture of gear-shift shaft under over-torsion stress.",
        "keywords": [
            "Quenching-and-tempering",
            "Gear-shift shaft",
            "Failure analysis",
            "Torsion fracture"
        ],
        "authors": [
            {
                "name": "Chen Ming",
                "org": "Guangzhou "
            },
            {
                "name": "Tan Ying",
                "org": "Guangzhou "
            },
            {
                "name": "Cao Biao",
                "org": "Guangzhou "
            },
            {
                "name": "Mo Mingzhen",
                "org": "Guangzhou "
            },
            {
                "name": "Zhou Qi",
                "org": "Guangzhou "
            },
            {
                "name": "Li Xiaomin",
                "org": "Guangzhou "
            }
        ],
        "venue": "Small Internal Combustion Engine and Motorcycle",
        "year": 2007
    },
    "Lwmoyg2Q": {
        "id": "Lwmoyg2Q",
        "title": "Failure Analysis on Crankshaft in a Motorcycle Engine",
        "abstract": "The crankshaft in a motorcycle engine fractured after the service of 6350km.The fracture cause of the crankshaft was analyzed by facture surface observation,surface mark analysis,chemical composition analysis,metallographic examination and hardness testing.The results show that there existed electrical burn at the bottom of the crankshaft locating slot,which was caused by electrode contact before fixing the locating pin.There was stress concentration at the electrically burned zone.As a result,cracks initiated from the electrically burned zone under the effect of service load,and finally,the crankshaft fractured.",
        "keywords": [
            "fatigue fracture",
            "electrode burn",
            "crankshaft"
        ],
        "authors": [
            {
                "name": "TAN Ying",
                "org": "Guangdong Entry-Exit Inspection & Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "CAO Biao",
                "org": "Guangdong Entry-Exit Inspection & Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "CHEN Ming",
                "org": "Guangdong Entry-Exit Inspection & Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "MO Ming-zhen",
                "org": "Guangdong Entry-Exit Inspection & Quarantine Technology Center,Guangzhou ,China"
            }
        ],
        "venue": "Failure Analysis and Prevention",
        "year": 2009
    },
    "h7GKdHZe": {
        "id": "h7GKdHZe",
        "title": "Failure analysis on early cracking of car speed changing box",
        "abstract": "The microstructure,chemical composition of the early cracked shell of gear-box were examined and the fracture morphology was observed and analyzed.The results show that the large load affected on parts and existence of casting flaw reduce the actual carryring capacity of parts.Which result in the early fatigue fracture.",
        "keywords": [
            "casting flaw",
            "the shell of gear-box",
            "fatigue fracture"
        ],
        "authors": [
            {
                "name": "MO Ming-zhen",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "TAN Ying",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "CAO Biao",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "CHEN Ming",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            }
        ],
        "venue": "Heat Treatment of Metals",
        "year": 2011
    },
    "TKv8FaX9": {
        "id": "TKv8FaX9",
        "title": "Method of Identification the Grain-oriented and Non-oriented for the Cold-rolled Electrical Steel Sheet",
        "abstract": "Iron loss and magnetic polarization were measured by Epstein frame on the transverse and vertical sheet,their ratio was calculated and their difference was summarized.The quantitative criterion was given on how to identify the grain-oriented and non-oriented for the cold-rolled electrical steel sheet.",
        "keywords": [
            "Grain-Oriented",
            "Cold-Rolled Electrical Steel Sheet",
            "Magnetic Polarization",
            "Iron Loss"
        ],
        "authors": [
            {
                "name": "Mo Mingzhen",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou,Guangdong,"
            },
            {
                "name": "Chen Ming",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou,Guangdong,"
            },
            {
                "name": "Tan Y",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou,Guangdong,"
            },
            {
                "name": "Cao Biao",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou,Guangdong,"
            }
        ],
        "venue": "Journal of Inspection and Quarantine",
        "year": 2010
    },
    "m0agVYrz": {
        "id": "m0agVYrz",
        "title": "Analysis on Fracture of Forklift Clip Arm",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "\u9648\u660e",
                "org": ""
            },
            {
                "name": "\u8c2d\u83b9",
                "org": ""
            },
            {
                "name": "\u5468\u5d0e",
                "org": ""
            },
            {
                "name": "\u66f9\u6807",
                "org": ""
            },
            {
                "name": "\u83ab\u660e\u73cd",
                "org": ""
            }
        ],
        "venue": "Metal Hotworking Technology",
        "year": 2007
    },
    "PaG8eWmP": {
        "id": "PaG8eWmP",
        "title": "Failure Analysis of Brake Drum in Motorcycle",
        "abstract": "By macroscopic and microstructure examination,fractography,chemical composition and hardness testing,etc.,the failure of the brake drum in motorcycle was analyzed.The results show that brake drum fracture is caused by spring fracture initially.The wrong steel grades of spring material,high hardness and poor quality of the surface are the main reasons for fatigue fracture of spring.",
        "keywords": [
            "brake drum",
            "failure analysis",
            "spring"
        ],
        "authors": [
            {
                "name": "LI Chengming",
                "org": "Guangdong Entry-exit Inspection and Quarantine Bureau,Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "TAN Ying",
                "org": "Guangdong Entry-exit Inspection and Quarantine Bureau,Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "MO Mingzhen",
                "org": "Guangdong Entry-exit Inspection and Quarantine Bureau,Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            }
        ],
        "venue": "Hot Working Technology",
        "year": 2012
    },
    "4fzK18Jp": {
        "id": "4fzK18Jp",
        "title": "Fracture Analysis on A CounterShaft of Motorcycle",
        "abstract": "A counter shaft made of 20CrMo was cracked in service.In order to examined the reason,the macrostructure and microstructure of fractured surface were investigated.The results show that the stress is concentrated at the point angle of the spline of the countershaft is the factor for resulting fatigue failure.Preventive action is given at the end.",
        "keywords": [
            "stress concentration",
            "countershaft",
            "engine",
            "fatigue fracture",
            "motorcycle"
        ],
        "authors": [
            {
                "name": "CHEN Gui-feng",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "MO Ming-zhen",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "TAN Ying",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "CHEN Ming",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            }
        ],
        "venue": "Equipment Manufacturing Technology",
        "year": 2010
    },
    "e5WT5anH": {
        "id": "e5WT5anH",
        "title": "Analysis on Rupture of Link in Motorbike Engine",
        "abstract": "Analysis on metallography,macro and fracture appearance were carried out on broken link in motorbike engine.The results showed that intensive attrition had happened between link and output spindle.The attrition leaded to stress concentration and high temperature which reduced the fatigue strength at local area.The larger carbides existing in that part also wrecked continuity of the base and accelerated the forming and expanding of the crack.",
        "keywords": [
            "fatigue rupture",
            "link",
            "failure analysis"
        ],
        "authors": [
            {
                "name": "CHEN Ming",
                "org": "Inspection Technology Center on Chemicals,Minerals & Metallic Materials of Guangzhou Entry-Exit Inspection & Quarantine Bureau,Guangzhou ,Guangdong,China"
            },
            {
                "name": "TAN Ying",
                "org": "Inspection Technology Center on Chemicals,Minerals & Metallic Materials of Guangzhou Entry-Exit Inspection & Quarantine Bureau,Guangzhou ,Guangdong,China"
            },
            {
                "name": "CAO Biao",
                "org": "Inspection Technology Center on Chemicals,Minerals & Metallic Materials of Guangzhou Entry-Exit Inspection & Quarantine Bureau,Guangzhou ,Guangdong,China"
            },
            {
                "name": "ZHOU Qi",
                "org": "Inspection Technology Center on Chemicals,Minerals & Metallic Materials of Guangzhou Entry-Exit Inspection & Quarantine Bureau,Guangzhou ,Guangdong,China"
            },
            {
                "name": "LIU Jian-bin",
                "org": "Inspection Technology Center on Chemicals,Minerals & Metallic Materials of Guangzhou Entry-Exit Inspection & Quarantine Bureau,Guangzhou ,Guangdong,China"
            }
        ],
        "venue": "Physics Examination and Testing",
        "year": 2006
    },
    "8j3eAXNd": {
        "id": "8j3eAXNd",
        "title": "Fracture Analysis of Screw",
        "abstract": "Fixing screws of loudspeaker was fractured during transportation.Fracture Sample were analyzed by means of SEM,microscope,ICP and hardness tester.The results show Hydrogen-embrittlement was the reason of fracture. The main reason was improper heat treatment of screws.It was carburized too deep case and hydrogen congregating too much inside screw,so it is difficult to diffuse in the tempered.The other reason was hydrogen in the screws had been not eliminated after plating.",
        "keywords": [
            "screw",
            "carburization",
            "plating",
            "hydrogen-embrittlement fracture"
        ],
        "authors": [
            {
                "name": "TAN Ying",
                "org": "Technology Center,Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            },
            {
                "name": "ZHOU Qi",
                "org": "Technology Center,Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            },
            {
                "name": "CAO Biao",
                "org": "Technology Center,Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            },
            {
                "name": "CHEN Ming",
                "org": "Technology Center,Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou ,China"
            }
        ],
        "venue": "Heat Treatment of Metals",
        "year": 2007
    },
    "mKsKly6z": {
        "id": "mKsKly6z",
        "title": "Failure Analysis on Gear Pump",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "TAN Ying",
                "org": "Technology Center,Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou Guangdong ,China"
            },
            {
                "name": "CAO Biao",
                "org": "Technology Center,Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou Guangdong ,China"
            },
            {
                "name": "CHEN Ming",
                "org": "Technology Center,Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou Guangdong ,China"
            },
            {
                "name": "ZHANG De-shi",
                "org": "Zhejiang Entry-Exit Inspection and Quarantine Bureau,Hangzhou Zhejiang ,China"
            },
            {
                "name": "LI Xiao-min",
                "org": "Technology Center,Guangdong Entry-Exit Inspection and Quarantine Bureau,Guangzhou Guangdong ,China"
            }
        ],
        "venue": "Heat Treatment of Metals",
        "year": 2007
    },
    "mwbYi8VS": {
        "id": "mwbYi8VS",
        "title": "Failure Analysis of Truck Engine Cylinder Liner",
        "abstract": "By macroscopic and microstructure examination,fractography,chemical composition testing,hardness testing and so on,the failure of the truck engine cylinder liner was analyzed.The results show that the early fatigue fracture of the truck engine cylinder liner was caused by micro-cracks.",
        "keywords": [
            "truck engine",
            "cylinder liner",
            "failure analysis",
            "fatigue fracture",
            "micro-cracks"
        ],
        "authors": [
            {
                "name": "LI Chengming",
                "org": "Guangdong Entry-exit Inspection and Quarantine Bureau,Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "TAN Ying",
                "org": "Guangdong Entry-exit Inspection and Quarantine Bureau,Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "MO Mingzhen",
                "org": "Guangdong Entry-exit Inspection and Quarantine Bureau,Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            }
        ],
        "venue": "Hot Working Technology",
        "year": 2012
    },
    "h6w41w5a": {
        "id": "h6w41w5a",
        "title": "FRACTURE ANALYSIS OF THE MOTOR VALVE SPRING",
        "abstract": "Air valve spring used in motorcycle produced by a factory of Guangdong failured after the motorcycle drived for 1 500km.The fracture was analysed by using SEM\u3001 metallography and ICP-AES.The results showed that the fracture was of typical fatigue fracture,and surface defects were the main factor resulting in the failure of the air valve spring.",
        "keywords": [
            "Fracture analysis",
            "Fracture",
            "Spring"
        ],
        "authors": [
            {
                "name": "LIN Li-zhen",
                "org": "Guangzhou Entry-Exit Inspection and Quanrantine Bureau,Guangzhou ,China"
            },
            {
                "name": "CAO Biao",
                "org": "Guangzhou Entry-Exit Inspection and Quanrantine Bureau,Guangzhou ,China"
            },
            {
                "name": "TAN Ying",
                "org": "Guangzhou Entry-Exit Inspection and Quanrantine Bureau,Guangzhou ,China"
            },
            {
                "name": "CHEN Ming",
                "org": "Guangzhou Entry-Exit Inspection and Quanrantine Bureau,Guangzhou ,China"
            }
        ],
        "venue": "Physical Testing and Chemical Analysis(Part A:Physical Testing)",
        "year": 2006
    },
    "pD4j0Grb": {
        "id": "pD4j0Grb",
        "title": "Fracture Analysis of an Iron Cultural Relic",
        "abstract": "An iron cultural relic fractured in the display cupboard.The failure cause of the cultural relic was analyzed by facture macroscopic observation,chemical composition analysis,metallographic examination and mechanical properties testing and so on.The results showed that there existed stress corrosion cracks in the iron cultural relic,which were caused by water absorbed by the iron cultural relic from the damp air,and existence of the water laid in the display cupboard speeded up the corrosion.The iron cultural relic was a casting art,so there were welding stress and comparatively high residual stress in the iron cultural relic because of the big thickness difference.It can be concluded that the fracture of the iron cultural relic resulted from corrosion and residual stress together.",
        "keywords": [
            "failure",
            "stress corrosion",
            "iron cultural relic"
        ],
        "authors": [
            {
                "name": "TAN Ying",
                "org": "Guangdong Entry-Exit Inspection & Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "MO Ming-zhen",
                "org": "Guangdong Entry-Exit Inspection & Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "CAO Biao",
                "org": "Guangdong Entry-Exit Inspection & Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "LI Cheng-ming",
                "org": "Guangdong Entry-Exit Inspection & Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "LI Hao",
                "org": "Guangdong Entry-Exit Inspection & Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "Chen Ming",
                "org": "Guangdong Entry-Exit Inspection & Quarantine Technology Center,Guangzhou ,China"
            }
        ],
        "venue": "Corrosion & Protection",
        "year": 2012
    },
    "wMkYQo80": {
        "id": "wMkYQo80",
        "title": "Cracking Analysis of Fixed Pillar in Aluminum Plate Straightening Machine",
        "abstract": "The fixed pillar of aluminum plate straightening machine cracked under the condition which its external load did not reach the design value. The failure of fixed pillar was analyzed by ways of macro-fractography, micro-fractography analysis and metallographic analysis. The result shows that the cracking of fixed pillar was caused by the casting defects. The defects were located at the stress zone of the fixed pillar where the hot spot and the riser were. The unreasonable design of the riser dimension resulted in feeding badness. The surface of the internal denseners near the riser was not cleaned, which formed incompletely melted denseners and shrinkage. So the stress concentration was formed in the discontinuous zone, which resulted in declining of the actual bearing capacity and was the main reason for the crack of the fixed pillar.",
        "keywords": [
            "Casting defect",
            "Cracking",
            "Fixed pillar"
        ],
        "authors": [
            {
                "name": "TAN Ying",
                "org": ""
            },
            {
                "name": "MO Ming-zhen",
                "org": ""
            },
            {
                "name": "ZHOU Qi",
                "org": ""
            },
            {
                "name": "CAO Biao",
                "org": ""
            }
        ],
        "venue": "Foundry",
        "year": 2013
    },
    "JeLj9zmN": {
        "id": "JeLj9zmN",
        "title": "Analysis on Fracture Cause of Exhaust Valve of Motorbike Engine",
        "abstract": "Analyses on macro,metallography,chemistry and fracture appearance were carried on broken exhaust valve in motorbike engine.The results show that dense \u03b5-phase with corrosion-resistance isn't formed on the surface of exhaust valve during nitriding,which reduces the oxidation-resistance of it.Oxidizing-corrosion fatigue happened because of high temperature and oxidizing atmosphere during working,and caused the rupture of the exhaust valve.",
        "keywords": [
            "nitriding",
            "corrosion fatigue",
            "oxidation",
            "failure analysis",
            "exhaust valve"
        ],
        "authors": [
            {
                "name": "CHEN Ming",
                "org": "Guangdong Entry-exit Inspection & Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "CAO Biao",
                "org": "Guangdong Entry-exit Inspection & Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "TAN Ying",
                "org": "Guangdong Entry-exit Inspection & Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "ZHOU Qi",
                "org": "Guangdong Entry-exit Inspection & Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "MO Ming-zhen",
                "org": "Guangdong Entry-exit Inspection & Quarantine Technology Center,Guangzhou ,China"
            }
        ],
        "venue": "Hot Working Technology",
        "year": 2007
    },
    "zhEOYS3v": {
        "id": "zhEOYS3v",
        "title": "Fracture Analysis on Breaking of 45 Steel Rods during Drawing",
        "abstract": "The fracture of 45 steel rods during drawing was analysed by using SEM,EDS and metallography.The results showed that the metallurgical defects such as inclusions,coarse crystal grains and asymmetry of the grain size were the main reason resulting in fracture of the steel rods during drawing.",
        "keywords": [
            "steel rods",
            "fracture",
            "drawing"
        ],
        "authors": [
            {
                "name": "GUAN Li-jun",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,Guangdong,China"
            },
            {
                "name": "ZHANG Qing-an",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,Guangdong,China"
            },
            {
                "name": "CAO Biao",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,Guangdong,China"
            },
            {
                "name": "TAN Y",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,Guangdong,China"
            }
        ],
        "venue": "Physics Examination and Testing",
        "year": 2007
    },
    "q36ZkvCN": {
        "id": "q36ZkvCN",
        "title": "Analysis of Crack in Cast Copper Alloy Tap Valve",
        "abstract": "The macrostructure and microstructure of cracked cast copper alloy tap valve were obseverd by SEM and OM,and the chemical composition and hardness were analyzed.The results show that the cracking of the tap valve is brittle crack,which is due to overheat to cause the formation of defects,such as coarse grains,Widmanstatten structure and porosity.The crack can be avoided by controlling casting temperature and the cooling rate.",
        "keywords": [
            "Brittle crack",
            "Tap valve",
            "Cast copper alloy",
            "Overheat"
        ],
        "authors": [
            {
                "name": "MO Ming-zhen",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "TAN Ying",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "CHEN Ming",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            },
            {
                "name": "CAO Biao",
                "org": "Guangdong Inspection and Quarantine Technology Center,Guangzhou ,China"
            }
        ],
        "venue": "Foundry Technology",
        "year": 2008
    },
    "ygCjaUis": {
        "id": "ygCjaUis",
        "title": "Query based hybrid learning models for adaptively adjusting locality",
        "abstract": "Local learning employs locality adjusting mechanisms to give local function estimation for each query, while global learning tries to capture the global distribution characteristics of the entire training set. When fitting well with local characteristics of each individual region, the locality parameter may help local learning to improve performance. However, the real data distribution is impossible to get for a real-world problem, and thus an optimal locality is hard to get for each query. In addition, it is quite time-consuming to build an independent local model for each query. To solve these problems, we present strategies for estimating and tuning locality according to local distribution. Based on local distribution estimation, global learning and local learning are combined to achieve a good compromise between capacity and locality. In addition, multi-objective learning principles for the combination are also given. In implementation, a unique global model is first built on the entire training set based on empirical minimization principle. For each query, it is measured that whether the global model can well fit the vicinity space of the query. When an uneven local distribution is found, the locality of the model is tuned, and a specific local model will be built on the local region. To investigate the performance of hybrid models, we apply them to a typical learning problem-spam filtering, in which data are always found to be unevenly distributed. Experiments were conducted on five real-world corpora, namely PU1, PU2, PU3, PUA, and TREC07. It is shown that the hybrid models can achieve a better compromise between capacity and locality, and hybrid models outperform both global learning and local learning.",
        "keywords": [
            "pu2 corpora",
            "locality parameter",
            "query based hybrid learning models",
            "optimal locality",
            "learning (artificial intelligence)",
            "empirical minimization principle",
            "multiobjective learning principles",
            "information filtering",
            "global learning",
            "query independent local model",
            "pu1 corpora",
            "unsolicited e-mail",
            "pu3 corpora",
            "spam filtering",
            "trec07 corpora",
            "pua corpora",
            "adaptively adjusting locality mechanism",
            "global distribution characteristics",
            "local function estimation",
            "local learning",
            "local distribution estimation",
            "query processing",
            "support vector machines",
            "data models",
            "computational modeling",
            "tuning",
            "learning artificial intelligence"
        ],
        "authors": [
            {
                "name": "Yuanchun Zhu",
                "org": "Dept. of Machine Intell., Peking Univ., Beijing, China|c|"
            },
            {
                "name": "Guyue Mi",
                "org": "peking university"
            },
            {
                "name": "Ying Tan",
                "org": "peking university"
            }
        ],
        "venue": "IJCNN",
        "year": 2012
    },
    "XixSd26V": {
        "id": "XixSd26V",
        "title": "Nonlinear blind source separation using higher order statistics anda genetic algorithm",
        "abstract": "This paper presents a novel method for blindly separating unobservable independent source signals from their nonlinear mixtures. The demixing system is modeled using a parameterized neural network whose parameters can be determined under the criterion of independence of its outputs. Two cost functions based on higher order statistics are established to measure the statistical dependence of the outputs of the demixing system. The proposed method utilizes a genetic algorithm (GA) to minimize the highly nonlinear and nonconvex cost functions. The GA-based global optimization technique is able to obtain superior separation solutions to the nonlinear blind separation problem from any random initial values. Compared to conventional gradient-based approaches, the GA-based approach for blind source separation is characterized by high accuracy, robustness, and convergence rate. In particular, it is very suitable for the case of limited available data. Simulation results are discussed to demonstrate that the proposed GA-based approach is capable of separating independent sources from their nonlinear mixtures generated by a parametric separation model",
        "keywords": [
            "proposed GA-based approach",
            "genetic algorithm",
            "higher order statistic",
            "Nonlinear blind source separation",
            "blind source separation",
            "parametric separation model",
            "superior separation solution",
            "nonlinear mixture",
            "conventional gradient-based approach",
            "GA-based approach",
            "demixing system",
            "GA-based global optimization technique",
            "nonlinear blind separation problem"
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": "Chinese Univ. of Hong Kong"
            },
            {
                "name": "Jun Wang",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Evolutionary Computation",
        "year": 2001
    },
    "uFtLGd9b": {
        "id": "uFtLGd9b",
        "title": "Particle swarm optimization based learning method for process neural networks",
        "abstract": "This paper proposes a new learning method for process neural networks (PNNs) based on the Gaussian mixture functions and particle swarm optimization (PSO), called PSO-LM First, the weight functions of the PNNs are specified as the generalized Gaussian mixture functions (GGMFs) Second, a PSO algorithm is used to optimize the parameters, such as the order of GGMFs, the number of hidden neurons, the coefficients, means and variances of Gaussian functions and the thresholds in PNNs In PSO-LM, the parameter space is transformed from the function space to real number space by using GGMFs PSO can give a global search in the real number parameter space by avoiding the premature and gradient calculations in back propagation method According to our analysis and several experiments, PSO-LM can outperform current basis function expansion based learning method (BFE-LM) for PNNs and the classic back propagation neural networks (BPNNs).",
        "keywords": [
            "particle swarm optimization",
            "pso-lm first",
            "function space",
            "real number parameter space",
            "ggmfs pso",
            "pso algorithm",
            "gaussian mixture function",
            "process neural network",
            "generalized gaussian mixture function",
            "real number space",
            "gaussian function",
            "parameter space",
            "back propagation",
            "neural network",
            "weight function",
            "gaussian mixture model"
        ],
        "authors": [
            {
                "name": "Kun Liu",
                "org": "Key Laboratory of Machine Perception, Ministry of Education, Peking University, Beijing, China"
            },
            {
                "name": "Ying Tan",
                "org": "Key Laboratory of Machine Perception, Ministry of Education, Peking University, Beijing, China"
            },
            {
                "name": "Xingui He",
                "org": "Key Laboratory of Machine Perception, Ministry of Education, Peking University, Beijing, China"
            }
        ],
        "venue": "ISNN (1)",
        "year": 2010
    },
    "gd0dyk6I": {
        "id": "gd0dyk6I",
        "title": "Forecast of driving load of hybrid electric vehicles by using discrete cosine transform and Support Vector Machine",
        "abstract": "",
        "keywords": [
            "data mining",
            "automotive engineering",
            "kernel",
            "support vector machine",
            "optimization",
            "pollution",
            "support vector machines",
            "artificial neural networks",
            "energy management",
            "discrete cosine transform"
        ],
        "authors": [
            {
                "name": "Jian Yang",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Xi Huang",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Ying Tan",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Xingui He",
                "org": "Peking University(Peking University),Beijing,China"
            }
        ],
        "venue": "IJCNN",
        "year": 2008
    },
    "ub8AAKct": {
        "id": "ub8AAKct",
        "title": "A malware detection model based on a negative selection algorithm with penalty factor",
        "abstract": "A malware detection model based on a negative selection algorithm with penalty factor (NSAPF) is proposed in this paper. This\n model extracts a malware instruction library (MIL), containing instructions that tend to appear in malware, through deep instruction\n analysis with respect to instruction frequency and file frequency. From the MIL, the proposed model creates a malware candidate\n signature library (MCSL) and a benign program malware-like signature library (BPMSL) by splitting programs orderly into various\n short bit strings. Depending on whether a signature matches \u201cself\u201d, the NSAPF further divides the MCSL into two malware detection\n signature libraries (MDSL1 and MDSL2), and uses these as a two-dimensional reference for detecting suspicious programs. The\n model classifies suspicious programs as malware and benign programs by matching values of the suspicious programs with MDSL1\n and MDSL2. Introduction of a penalty factor C in the negative selection algorithm enables this model to overcome the drawback of traditional negative selection algorithms\n in defining the harmfulness of \u201cself\u201d and \u201cnonself\u201d, and focus on the harmfulness of the code, thus greatly improving the\n effectiveness of the model and also enabling the model to satisfy the different requirements of users in terms of true positive\n and false positive rates. Experimental results confirm that the proposed model achieves a better true positive rate on completely\n unknown malware and a better generalization ability while keeping a low false positive rate. The model can balance and adjust\n the true positive and false positive rates by adjusting the penalty factor C to achieve better performance.",
        "keywords": [
            "malware detection",
            "penalty factor",
            "artificial immune system",
            "negative selection algorithm",
            "mal- ware detection",
            "signature extraction",
            "false positive rate",
            "satisfiability",
            "negative selection"
        ],
        "authors": [
            {
                "name": "PengTao Zhang",
                "org": "Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, Beijing, 100871 China"
            },
            {
                "name": "Wei Wang",
                "org": "Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, Beijing, 100871 China"
            },
            {
                "name": "Ying Tan",
                "org": "Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, Beijing, 100871 China"
            }
        ],
        "venue": "Scientia Sinica(Informationis)",
        "year": 2011
    },
    "noGZ7ooZ": {
        "id": "noGZ7ooZ",
        "title": "Discriminant analysis via support vectors",
        "abstract": "In this paper, we show how support vector machine (SVM) can be employed as a powerful tool for k-nearest neighbor (kNN) classifier. A novel multi-class dimensionality reduction approach, discriminant analysis via support vectors (SVDA), is proposed. First, the SVM is employed to compute an optimal direction to discriminant each two classes. Then, the criteria of class separability is constructed. At last, the projection matrix is computed. The kernel mapping idea is used to derive the non-linear version, kernel discriminant via support vectors (SVKD). In SVDA, only support vectors are involved to compute the transformation matrix. Thus, the computational complexity can be greatly reduced for kernel based feature extraction. Experiments carried out on several standard databases show a clear improvement on LDA-based recognition.",
        "keywords": [
            "linear discriminant analysis",
            "support vector machine",
            "projection matrix",
            "discriminant analysis",
            "support vector",
            "fisher's criteria",
            "kernel discriminant",
            "discriminant analysis via support vectors",
            "lda-based recognition",
            "class separability",
            "clear improvement",
            "transformation matrix",
            "kernel mapping idea",
            "regularized discriminant analysis",
            "computational complexity",
            "feature extraction",
            "k nearest neighbor"
        ],
        "authors": [
            {
                "name": "Suicheng Gu",
                "org": "Key Laboratory of Machine Perception (MOE), Peking University, Beijing 100871, PR China and Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking Unive ..."
            },
            {
                "name": "Ying Tan",
                "org": "Key Laboratory of Machine Perception (MOE), Peking University, Beijing 100871, PR China and Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking Unive ..."
            },
            {
                "name": "Xingui He",
                "org": "Key Laboratory of Machine Perception (MOE), Peking University, Beijing 100871, PR China and Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking Unive ..."
            }
        ],
        "venue": "Neurocomputing",
        "year": 2010
    },
    "9HKa7nKG": {
        "id": "9HKa7nKG",
        "title": "GPU-based parallel particle swarm optimization",
        "abstract": "A novel parallel approach to run standard particle swarm optimization (SPSO) on Graphic Processing Unit (GPU) is presented in this paper. By using the general-purpose computing ability of GPU and based on the software platform of Compute Unified Device Architecture (CUDA) from NVIDIA, SPSO can be executed in parallel on GPU. Experiments are conducted by running SPSO both on GPU and CPU, respectively, to optimize four benchmark test functions. The running time of the SPSO based on GPU (GPU-SPSO) is greatly shortened compared to that of the SPSO on CPU (CPU-SPSO). Running speed of GPU-SPSO can be more than 11 times as fast as that of CPU-SPSO, with the same performance. compared to CPU-SPSO, GPU-SPSO shows special speed advantages on large swarm population applications and high dimensional problems, which can be widely used in real optimizing problems.",
        "keywords": [
            "novel parallel approach",
            "benchmark test function",
            "compute unified device architecture",
            "gpu-based parallel particle swarm",
            "special speed advantage",
            "large swarm population application",
            "high dimensional problem",
            "general-purpose computing ability",
            "graphic processing unit",
            "standard particle swarm optimization",
            "real optimizing problem",
            "programming",
            "computer graphics",
            "data mining",
            "central processing unit",
            "optimization",
            "ant colony optimization",
            "parallel processing",
            "kernel",
            "benchmark testing",
            "concurrent computing",
            "algorithm design and analysis",
            "machine intelligence",
            "graphics",
            "particle swarm optimization",
            "application software",
            "optimization problem",
            "computer architecture",
            "indexes"
        ],
        "authors": [
            {
                "name": "You Zhou",
                "org": "Key Laboratory of Machine Perception and Intelligence, Peking University, Ministry of Education and Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peki ..."
            },
            {
                "name": "Ying Tan",
                "org": "Key Laboratory of Machine Perception and Intelligence, Peking University, Ministry of Education and Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peki ..."
            }
        ],
        "venue": "IEEE Congress on Evolutionary Computation",
        "year": 2009
    },
    "Rmg7y01k": {
        "id": "Rmg7y01k",
        "title": "Concentration based feature construction approach for spam detection",
        "abstract": "Inspired by human immune system, a concentration based feature construction (CFC) approach which utilizes a two-element concentration vector as the feature vector is proposed for spam detection in this paper. In the CFC approach, dasiaselfpsila and dasianon-selfpsila concentrations are constructed by using dasiaselfpsila and dasianon-selfpsila gene libraries, respectively, and subsequently are used to form a vector with two elements of concentrations for characterizing the e-mail efficiently. As a result, the design of classifier actually amounts to establishing a mapping between two real-value inputs and one binary output. The classification of the e-mail is considered as an optimization problem aiming at minimizing a formulated cost function. A clonal particle swarm optimization (CPSO) algorithm proposed by the leading author is also employed for this purpose. Several classifiers including linear discriminant, multi-layer neural networks and support vector machine are used to verify the effectiveness and robustness of the CFC approach. Experimental results demonstrate that the proposed CFC approach not only has a very much fast speed but also gives 97% and 99% of accuracy just using a two-element concentration feature vector on corpus PU1 and Ling, respectively.",
        "keywords": [
            "e-mail classification",
            "e-mail filters",
            "feature construction approach",
            "cfc approach",
            "feature vector",
            "particle swarm optimisation",
            "proposed cfc approach",
            "concentration based feature construction",
            "spam detection",
            "unsolicited e-mail",
            "two-element concentration feature vector",
            "optimization problem",
            "support vector machine",
            "clonal particle swarm optimization",
            "feature construction",
            "classification",
            "two-element concentration vector",
            "human immune system",
            "binary output",
            "classification algorithms",
            "optimization",
            "immune system",
            "particle swarm optimization",
            "cost function",
            "robustness",
            "neural network",
            "support vector machines"
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": "Key Laboratory of Machine Perception and Intelligence and Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, MOE, Beijing, P. R. China"
            },
            {
                "name": "Chao Deng",
                "org": "Key Laboratory of Machine Perception and Intelligence and Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, MOE, Beijing, P. R. China"
            },
            {
                "name": "Guangchen Ruan",
                "org": "Key Laboratory of Machine Perception and Intelligence and Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, MOE, Beijing, P. R. China"
            }
        ],
        "venue": "IJCNN",
        "year": 2009
    },
    "gTOJyfVF": {
        "id": "gTOJyfVF",
        "title": "Using population based algorithms for initializing nonnegative matrix factorization",
        "abstract": "The nonnegative matrix factorization (NMF) is a boundconstrained low-rank approximation technique for nonnegative multivariate data. NMF has been studied extensively over the last years, but an important aspect which only has received little attention so far is a proper initialization of the NMF factors in order to achieve a faster error reduction. Since the NMF objective function is usually non-differentiable, discontinuous, and may possess many local minima, heuristic search algorithms are a promising choice as initialization enhancers for NMF. In this paper we investigate the application of five population based algorithms (genetic algorithms, particle swarm optimization, fish school search, differential evolution, and fireworks algorithm) as new initialization variants for NMF. Experimental evaluation shows that some of them are well suited as initialization enhancers and can reduce the number of NMF iterations needed to achieve a given accuracy. Moreover, we compare the general applicability of these five optimization algorithms for continuous optimization problems, such as the NMF objective function.",
        "keywords": [
            "particle swarm optimization",
            "initialization enhancers",
            "optimization algorithm",
            "continuous optimization problem",
            "nmf objective function",
            "new initialization variant",
            "nonnegative matrix factorization",
            "nmf factor",
            "heuristic search algorithm",
            "fish school search",
            "proper initialization"
        ],
        "authors": [
            {
                "name": "Andreas Janecek",
                "org": "Key Laboratory of Machine Perception (MOE), Peking University, Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, Beijing, China"
            },
            {
                "name": "Ying Tan",
                "org": "Key Laboratory of Machine Perception (MOE), Peking University, Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, Beijing, China"
            }
        ],
        "venue": "ICSI",
        "year": 2011
    },
    "lvxFIAT9": {
        "id": "lvxFIAT9",
        "title": "A GPU-based parallel fireworks algorithm for optimization",
        "abstract": "Swarm intelligence algorithms have been widely used to solve difficult real world problems in both academic and engineering domains. Thanks to the inherent parallelism, various parallelized swarm intelligence algorithms have been proposed to speed up the optimization process, especially on the massively parallel processing architecture GPUs. However, conventional swarm intelligence algorithms are usually not designed specifically for the GPU architecture.They neither can fully exploit the tremendous computational power of GPUs nor can extend effectively as the problem scales go large. To address this shortcoming, a novel GPU-based Fireworks Algorithm (GPU-FWA) is proposed in this paper. In order to fully leverage GPUs' high performance, GPU-FWA modified the original FWA so that it is more suitable for the GPU architecture. An implementation of GPU-FWA on the CUDA platform is presented and then tested on a suite of well-known benchmark optimization problems. We extensively evaluated GPU-FWA and compared it with FWA and PSO, with respect to both running time and solution quality, on a state-of-the-art commodity Fermi GPU.Experimental results demonstrate that GPU-FWA generally outperforms both FWA and PSO, and enjoys a significant speedup as high as 200x, compared to the sequential version of FWA and PSO running on an up-to-date CPU. GPU-FWA also enjoys the advantages of being easy to implement and scalable.",
        "keywords": [
            "high performance",
            "swarm intelligence algorithm",
            "optimization process",
            "various parallelized swarm intelligence",
            "gpu architecture",
            "leverage gpus",
            "conventional swarm intelligence algorithm",
            "gpu-based parallel fireworks algorithm",
            "original fwa",
            "fermi gpu",
            "parallel processing architecture gpus",
            "parallel computing",
            "gpu computing",
            "swarm intelligence"
        ],
        "authors": [
            {
                "name": "Ke Ding",
                "org": "Key Laboratory of Machine Perception (MOE), Peking University, Beijing, China"
            },
            {
                "name": "Shaoqiu Zheng",
                "org": "Key Laboratory of Machine Perception (MOE), Peking University, Beijing, China"
            },
            {
                "name": "Ying Tan",
                "org": "Key Laboratory of Machine Perception (MOE), Peking University, Beijing, China"
            }
        ],
        "venue": "GECCO",
        "year": 2013
    },
    "MJvZdOwZ": {
        "id": "MJvZdOwZ",
        "title": "Leveraging Genetic Algorithm to Compose Web Services in a Context-Aware Environment",
        "abstract": "In a context-aware pervasive environment, it is crucial to provide an efficient adaption mechanism to rapidly discover appropriate services and compose them to achieve user desired situation when context change. In this paper, we propose a GA(Genetic Algorithm) based novel service composition method in a context-aware environment. We first use Context Space model to represent context, situation, user preference and services in a unified formal way. Then we transform the service composition problem into a multi-objective optimization problem and utilize GA to find the optimal service composition based on user's preference. To affiliate the connection between context and services, we use a vector to represent each service to reflect which context types a service can change so as to utilize GA to find the best service composition. Confliction of services may happen during the GA process. In order to resolve the conflicts, we propose a SST(Service Similarity Tree) method to measure the similarity among services to find out the best alternative. Finally, we design and implement a simulation experiment to verify our method. The results shows that our method can leverage GA to synthesis appropriate services to achieve user desired goal in an efficient way.",
        "keywords": [
            "user preference",
            "context type",
            "ga process",
            "leveraging genetic algorithm",
            "compose web services",
            "optimal service composition",
            "context-aware environment",
            "synthesis appropriate service",
            "service composition problem",
            "appropriate service",
            "best service composition",
            "context change",
            "novel service composition method",
            "ubiquitous computing",
            "genetic algorithms",
            "genetic algorithm",
            "web services"
        ],
        "authors": [
            {
                "name": "Zhichao Zhang",
                "org": ""
            },
            {
                "name": "Shaoqiu Zheng",
                "org": ""
            },
            {
                "name": "Weiping Li",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Zhonghai Wu",
                "org": ""
            },
            {
                "name": "Wei Tan",
                "org": ""
            }
        ],
        "venue": "SMC",
        "year": 2013
    },
    "8OzWbo9c": {
        "id": "8OzWbo9c",
        "title": "Accelerating Fireworks Algorithm with Weight-Based Guiding Sparks.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yuhao Li",
                "org": ""
            },
            {
                "name": "Jun Yu",
                "org": ""
            },
            {
                "name": "Hideyuki Takagi",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            }
        ],
        "venue": "ICSI (1)",
        "year": 2019
    },
    "7UL3rse5": {
        "id": "7UL3rse5",
        "title": "Hausdorff distance with k-nearest neighbors",
        "abstract": "Hausdorff distance (HD) is an useful measurement to determine the extent to which one shape is similar to another, which is one of the most important problems in pattern recognition, computer vision and image analysis. Howeverm, HD is sensitive to outliers. Many researchers proposed modifications of HD. HD and its modifications are all based on computing the distance from each point in the model image to its nearest point in the test image, collectively called nearest neighbor based Hausdorff distances (NNHDs). In this paper, we propose modifications of Hausdorff distance measurements by using k-nearest neighbors (kNN). We use the average distance from each point in the model image to its kNN in the test image to replace the NN procedures of NNHDs and obtain the Hausdorff distance based on kNN, named kNNHDs. When k=1, kNNHDs are equal to NNHDs. kNNHDs inherit the properties of outliers tolerance from the prototypes in NNHDs and are more tolerant to noise.",
        "keywords": [
            "hausdorff distance",
            "computer vision",
            "nn procedure",
            "hausdorff distance measurement",
            "outliers tolerance",
            "test image",
            "nearest point",
            "k-nearest neighbor",
            "average distance",
            "image analysis",
            "model image",
            "face recognition",
            "k nearest neighbor"
        ],
        "authors": [
            {
                "name": "Jun Wang",
                "org": "Key Laboratory of Machine Perception (Ministry of Education), Peking University, P.R. China,Department of Machine Intelligence, School of EECS, Peking University, P.R. China"
            },
            {
                "name": "Ying Tan",
                "org": "Key Laboratory of Machine Perception (Ministry of Education), Peking University, P.R. China,Department of Machine Intelligence, School of EECS, Peking University, P.R. China"
            }
        ],
        "venue": "ICSI",
        "year": 2012
    },
    "TfdN1aAt": {
        "id": "TfdN1aAt",
        "title": "KNOB Particle Swarm Optimizer",
        "abstract": "\n It is not trivial to tune the swarm behavior just by parameter setting because of the randomness, complexity and dynamic involved\n in particle swarm optimizer (PSO). Hundreds of variants in the literature of last decade, brought various mechanism or ideas,\n sometimes also from outside of the traditional metaheuristics field, to tune the swarm behavior. While, in the same time,\n additional parameters have to be afforded. This paper proposes a new mechanism, named KNOB, to directly tune the swarm behavior\n through parameter setting of PSO. KNOB is defined as the first principal component of the statistical probability sequence\n of exploration and exploitation allocation along the search process. The using of the KNOB to tune PSO by parameter setting\n is realized through a statistical mapping, between the parameter set and the KNOB, learned by a radial basis function neural\n network (RBFNN) simulation model. In this way, KNOB provides an easy way to tune PSO directly by its parameter setting. A\n simple application of KNOB to promote is presented to verify the mechanism of KNOB.\n \n ",
        "keywords": [
            "search strategy",
            "parameter setting",
            "new mechanism",
            "swarm behavior",
            "additional parameter",
            "exploitation",
            "statistical mapping",
            "statistical probability sequence",
            "exploration",
            "parameter set",
            "knob particle swarm optimizer",
            "knob.",
            "pso knob",
            "various mechanism",
            "particle swarm optimizer",
            "simulation model",
            "principal component"
        ],
        "authors": [
            {
                "name": "Junqi Zhang",
                "org": "Tongji University Key Laboratory of Embedded System and Service Computing, Ministry of Education, Department of Computer Science and Technology Shanghai 200092 China"
            },
            {
                "name": "Kun Liu",
                "org": "Peking University Key Laboratory of Machine Perception, Ministry of Education, Department of Machine Intelligence, School of Electronics Engineering and Computer Science Beijing 100871 China"
            },
            {
                "name": "Ying Tan",
                "org": "Peking University Key Laboratory of Machine Perception, Ministry of Education, Department of Machine Intelligence, School of Electronics Engineering and Computer Science Beijing 100871 China"
            }
        ],
        "venue": "international conference on swarm intelligence",
        "year": 2010
    },
    "pOSazdRg": {
        "id": "pOSazdRg",
        "title": "Learning Distributed Coordinated Policy in Catching Game with Multi-Agent Reinforcement Learning.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Xiangyu Liu",
                "org": "Key Laboratory of Machine Perception (MOE), Peking University#TAB#"
            },
            {
                "name": "Ying Tan",
                "org": "Key Laboratory of Machine Perception (MOE), Peking University#TAB#"
            }
        ],
        "venue": "IJCNN",
        "year": 2019
    },
    "n0C0WyfC": {
        "id": "n0C0WyfC",
        "title": "Advances in Swarm Intelligence, First International Conference, ICSI 2010, Beijing, China, June 12-15, 2010, Proceedings, Part II",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Yuhui Shi",
                "org": ""
            },
            {
                "name": "Kay Chen Tan",
                "org": ""
            }
        ],
        "venue": "ICSI (1)",
        "year": 2010
    },
    "SJMmMQMW": {
        "id": "SJMmMQMW",
        "title": "Concentric spatial extension based particle swarm optimization inspired by brood sorting in ant colonies",
        "abstract": "In this paper, a concentric spatial extension based particle swarm optimization (CSE-PSO) is proposed by combining the spatial extension with the brood sorting in ant colonies, which leads to a concentric spatial extension scheme for the PSO. The brood sorting in ant colonies endows the particles in PSO with different radii adaptively according their distances to the best position of the swarm. In such a way, the search space in the CSE-PSO is not only enlarged greatly but also the diversity of the swarm in the CSE-PSO is increased accordingly. Meanwhile, a better trade-off between exploration and exploitation in the PSO is achieved by the concentric spatial extension. Simulation results on the fifteen benchmark test functions announced in IEEE CEC'2005 show that the proposed CSE-PSO is not only capable of speeding up the convergence but also improving the performance of global optimizer greatly on all the fifteen benchmark test functions.",
        "keywords": [
            "concentric spatial extension",
            "ant colonies",
            "particle swarm optimisation",
            "global optimizer",
            "brood sorting",
            "particle swarm optimization",
            "ant colony",
            "sorting",
            "data mining",
            "probability density function",
            "global optimization",
            "simulation",
            "benchmark testing",
            "search space",
            "convergence"
        ],
        "authors": [
            {
                "name": "Junqi Zhang",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Ying Tan",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Xingui He",
                "org": "Peking University(Peking University),Beijing,China"
            }
        ],
        "venue": "SIS",
        "year": 2009
    },
    "yUOiaPXh": {
        "id": "yUOiaPXh",
        "title": "A Hierarchical Artificial Immune Model for Virus Detection",
        "abstract": "As viruses become more complex, existing antivirus methods are inefficient to detect various forms of viruses, especially new variants and unknown viruses. Inspired by immune system, a hierarchical artificial immune system (AIS) model, which is based on matching in three layers, is proposed to detect a variety of forms of viruses. In the bottom layer, a non-stochastic but guided candidate virus gene library is generated by statistical information of viral key codes. Then a detecting virus gene library is upgraded from the candidate virus gene library using negative selection. In the middle layer, a novel storage method is used to keep a potential relevance between different signatures on the individual level, by which the mutual cooperative information of each instruction in a virus program can be collected. In the top layer, an overall matching process can reduce the information loss considerably. Experimental results indicate that the proposed model can recognize obfuscated viruses efficiently with an averaged recognition rate of 94%, including new variants of viruses and unknown viruses.",
        "keywords": [
            "computer viruses",
            "virus program",
            "unknown virus",
            "negative selection",
            "bottom layer",
            "new variant",
            "middle layer",
            "viral key codes",
            "obfuscated virus",
            "mutual cooperative information",
            "virus detection",
            "hierarchical artificial immune model",
            "digital signatures",
            "virus gene library detection",
            "virus gene library",
            "statistical information",
            "candidate virus gene library",
            "information loss",
            "immune system",
            "dna",
            "artificial immune system",
            "law"
        ],
        "authors": [
            {
                "name": "Wei Wang",
                "org": ""
            },
            {
                "name": "Pengtao Zhang",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Xingui He",
                "org": ""
            }
        ],
        "venue": "CIS (1)",
        "year": 2009
    },
    "zlJtICOB": {
        "id": "zlJtICOB",
        "title": "Frequency cosine transform: A bridge between gradient based frequency transform and discrete cosine transform",
        "abstract": "Discrete cosine transform(DCT) is one of the most powerful tools in image processing. In this paper, we show that each basis of the two dimensional discrete cosine transform (2D-DCT) is an ldquoeigenvectorrdquo of the frequency matrix which is used to obtain basis images of a two dimensional frequency transform (2D-FRT). We also connect the FRT and cosine transform in 1D continuous model. Then, the frequency cosine transform (FCT), is proposed based on the FRT and the DCT. The partial frequency cosine transform (PFCT) is given and discussed in details. It is shown that the FCT can be regarded as a special case of FRT or DCT and it is as sophisticated as the FRT and as fast as the DCT.",
        "keywords": [
            "image processing",
            "laplacian smoothing",
            "discrete cosine transform",
            "discrete cosine transform(dct)",
            "2d frequency transform",
            "partial frequency cosine transform",
            "discrete cosine transforms",
            "gradient based frequency transform",
            "frequency transform(frt)",
            "feature extraction",
            "frequency cosine transform(fct)",
            "gradient methods",
            "eigenvector",
            "frequency matrix",
            "eigenvalues and eigenfunctions",
            "local gradient",
            "neural networks",
            "frequency",
            "signal processing",
            "machine intelligence",
            "cosine transform"
        ],
        "authors": [
            {
                "name": "Suicheng Gu",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Ying Tan",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Xingui He",
                "org": "Peking University(Peking University),Beijing,China"
            }
        ],
        "venue": "Nanjing",
        "year": 2008
    },
    "3KeeiMLc": {
        "id": "3KeeiMLc",
        "title": "A danger theory inspired learning model and its application to spam detection",
        "abstract": "This paper proposes a Danger Theory (DT) based learning (DTL) model for combining classifiers. Mimicking the mechanism of DT, three main components of the DTL model, namely signal I, danger signal and danger zone, are well designed and implemented so as to define an immune based interaction between two grounding classifiers of the model. In addition, a self-trigger process is added to solve conflictions between the two grounding classifiers. The proposed DTL model is expected to present a more accuracy learning method by combining classifiers in a way inspired from DT. To illustrate the application prospects of the DTL model, we apply it to a typical learning problem -- e-mail classification, and investigate its performance on four benchmark corpora using 10-fold cross validation. It is shown that the proposed DTL model can effectively promote the performance of the grounding classifiers.",
        "keywords": [
            "benchmark corpus",
            "typical learning problem",
            "grounding classifier",
            "application prospect",
            "danger theory",
            "proposed dtl model",
            "danger zone",
            "dtl model",
            "10-fold cross validation",
            "danger signal"
        ],
        "authors": [
            {
                "name": "Yuanchun Zhu",
                "org": "Key Laboratory of Machine Perception (MOE), Peking University, Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, Beijing, China"
            },
            {
                "name": "Ying Tan",
                "org": "Key Laboratory of Machine Perception (MOE), Peking University, Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, Beijing, China"
            }
        ],
        "venue": "ICSI (1)",
        "year": 2011
    },
    "n1RSIlLu": {
        "id": "n1RSIlLu",
        "title": "Class-wise information gain",
        "abstract": "",
        "keywords": [
            "feature selection",
            "feature extraction",
            "cross validation",
            "information content"
        ],
        "authors": [
            {
                "name": "pengtao zhang",
                "org": "peking university"
            },
            {
                "name": "ying tan",
                "org": "peking university"
            }
        ],
        "venue": "",
        "year": 2013
    },
    "GFTWRfpW": {
        "id": "GFTWRfpW",
        "title": "Laplacian smoothing transform for face recognition",
        "abstract": "In this paper, we investigate how to extract the lowest frequency features from an image. A novel Laplacian smoothing transform (LST) is proposed to transform an image into a sequence, by which low frequency features of an image can be easily extracted for a discriminant learning method for face recognition. Generally, the LST is able to be an efficient dimensionality reduction method for face recognition problems. Extensive experimental results show that the LST method performs better than other pre-processing methods, such as discrete cosine transform (DCT), principal component analysis (PCA) and discrete wavelet transform (DWT), on ORL, Yale and PIE face databases. Under the leave one out strategy, the best performance on the ORL and Yale face databases is 99.75% and 99.4%; however, in this paper, we improve both to 100% with a fast linear feature extraction method for the first time.",
        "keywords": [],
        "authors": [
            {
                "name": "SuiCheng Gu",
                "org": "Key Laboratory of Machine Perception (MOE); Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, Beijing, 100871 China"
            },
            {
                "name": "Ying Tan",
                "org": "Key Laboratory of Machine Perception (MOE); Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, Beijing, 100871 China"
            },
            {
                "name": "XinGui He",
                "org": "Key Laboratory of Machine Perception (MOE); Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, Beijing, 100871 China"
            }
        ],
        "venue": "Scientia Sinica(Informationis)",
        "year": 2011
    },
    "LziWNx4h": {
        "id": "LziWNx4h",
        "title": "Fireworks Algorithm and Its Variants for Solving ICSI2014 Competition Problems.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Shaoqiu Zheng",
                "org": ""
            },
            {
                "name": "Lang Liu",
                "org": ""
            },
            {
                "name": "Chao Yu",
                "org": ""
            },
            {
                "name": "Junzhi Li",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            }
        ],
        "venue": "ICSI",
        "year": 2014
    },
    "87dfOp2i": {
        "id": "87dfOp2i",
        "title": "Parameter Optimization of Local-Concentration Model for Spam Detection by Using Fireworks Algorithm.",
        "abstract": "This paper proposes a new framework that optimizes anti-spam model with heuristic swarm intelligence optimization algorithms, and this framework could integrate various classifiers and feature extraction methods. In this framework, a swarm intelligence algorithm is utilized to optimize a parameter vector, which is composed of parameters of a feature extraction method and parameters of a classifier, considering the spam detection problem as an optimization process which aims to achieve the lowest error rate. Also, 2 experimental strategies were designed to objectively reflect the performance of the framework. Then, experiments were conducted, using the Fireworks Algorithm (FWA) as the swarm intelligence algorithm, the Local Concentration (LC) approach as the feature extraction method, and SVM as the classifier. Experimental results demonstrate that the framework improves the performance on the corpora PU1, PU2, PU3 and PUA, while the computational efficiency is applicable in real world. \u00a9 2013 Springer-Verlag Berlin Heidelberg.",
        "keywords": [
            "fireworks algorithm",
            "local concentration approach",
            "parameter optimization",
            "spam detection"
        ],
        "authors": [
            {
                "name": "Wenrui He",
                "org": ""
            },
            {
                "name": "Guyue Mi",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            }
        ],
        "venue": "ICSI (1)",
        "year": 2013
    },
    "vbNDEqTS": {
        "id": "vbNDEqTS",
        "title": "A novel genetic programming based morphological image analysis algorithm",
        "abstract": "This paper gives an applicable genetic programming(GP) approach to solve the binary image analysis and gray scale image enhancement problems. By showing a section of binary image and the corresponding goal image, this algorithm automatically produces a mathematic morphological operation sequence to transform the target into the goal. While the operation sequence is applied to the whole image, the objective of image analysis is achieved. With well-defined chromosome structure and evolution strategy, the effectiveness of evolution is promoted and more complex morphological operations can be composed in a short sequence. In addition, this algorithm is also applied to infrared finger vein gray scale images to enhance the region of interest. Whose effect is examined by an application of identity authentication, and the accuracy of authentication is promoted.",
        "keywords": [
            "mathematic morphological operation sequence",
            "operation sequence",
            "gray scale image",
            "novel genetic programming",
            "binary image",
            "binary image analysis",
            "short sequence",
            "morphological image analysis algorithm",
            "image analysis",
            "gray scale image enhancement",
            "whole image",
            "corresponding goal image",
            "region of interest",
            "infrared",
            "evolution strategy",
            "genetic programming"
        ],
        "authors": [
            {
                "name": "Jun Wang",
                "org": "Peking University, Beijing, China"
            },
            {
                "name": "Ying Tan",
                "org": "Peking University, Beijing, China"
            }
        ],
        "venue": "GECCO",
        "year": 2010
    },
    "mUVwSfZi": {
        "id": "mUVwSfZi",
        "title": "Advances in swarm intelligence : first international conference, ICSI 2010, Beijing, China, June 12-15, 2010, proceedings",
        "abstract": "",
        "keywords": [
            "swarm intelligence"
        ],
        "authors": [
            {
                "name": "ying tan",
                "org": ""
            },
            {
                "name": "yuhui shi",
                "org": ""
            },
            {
                "name": "k c tan",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2010
    },
    "I6bXGSkJ": {
        "id": "I6bXGSkJ",
        "title": "A malware detection model based on a negative selection algorithm with penalty factor",
        "abstract": "A malware detection model based on a negative selection algorithm with penalty factor (NSAPF) is proposed in this paper. This model extracts a malware instruction library (MIL), containing instructions that tend to appear in malware, through deep instruction analysis with respect to instruction frequency and file frequency. From the MIL, the proposed model creates a malware candidate signature library (MCSL) and a benign program malware-like signature library (BPMSL) by splitting programs orderly into various short bit strings. Depending on whether a signature matches \"self\", the NSAPF further divides the MCSL into two malware detection signature libraries (MDSL1 and MDSL2), and uses these as a two-dimensional reference for detecting suspicious programs. The model classifies suspicious programs as malware and benign programs by matching values of the suspicious programs with MDSL1 and MDSL2. Introduction of a penalty factor C in the negative selection algorithm enables this model to overcome the drawback of traditional negative selection algorithms in defining the harmfulness of \"self\" and \"nonself\", and focus on the harmfulness of the code, thus greatly improving the effectiveness of the model and also enabling the model to satisfy the different requirements of users in terms of true positive and false positive rates. Experimental results confirm that the proposed model achieves a better true positive rate on completely unknown malware and a better generalization ability while keeping a low false positive rate. The model can balance and adjust the true positive and false positive rates by adjusting the penalty factor C to achieve better performance.",
        "keywords": [
            "penalty factor",
            "artificial immune system",
            "negative selection algorithm",
            "mal- ware detection",
            "signature extraction",
            "malware detection"
        ],
        "authors": [
            {
                "name": "PengTao Zhang",
                "org": "Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, Beijing, 100871, China ; Key Laboratory of Machine Perception, Ministry of Education, Peking University, Beijing, 100871, China"
            },
            {
                "name": "Wei Wang",
                "org": "Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, Beijing, 100871, China ; Key Laboratory of Machine Perception, Ministry of Education, Peking University, Beijing, 100871, China"
            },
            {
                "name": "Ying Tan",
                "org": "Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, Beijing, 100871, China ; Key Laboratory of Machine Perception, Ministry of Education, Peking University, Beijing, 100871, China"
            }
        ],
        "venue": "\u4e2d\u56fd\u79d1\u5b66:\u4fe1\u606f\u79d1\u5b66(\u82f1\u6587\u7248)",
        "year": 2010
    },
    "GPmCEutD": {
        "id": "GPmCEutD",
        "title": "A novel genetic programming algorithm for designing morphological image analysis method",
        "abstract": "In this paper, we propose an applicable genetic programming approach to solve the problems of binary image analysis and gray scale image enhancement. Given a section of original image and the corresponding goal image, the proposed algorithm evolves for generations and produces a mathematic morphological operation sequence, and the result performed by which is close to the goal. When the operation sequence is applied to the whole image, the objective of image analysis is achieved. In this sequence, only basic morphological operations-- erosion and dilation, and logical operations are used. The well-defined chromosome structure leads brings about more complex morphological operations can be composed in a short sequence. Because of a reasonable evolution strategy, the evolution effectiveness of this algorithm is guaranteed. Tested by the binary image features analysis, this algorithm runs faster and is more accurate and intelligible than previous works. In addition, when this algorithm is applied to infrared finger vein gray scale images to enhance the region of interest, more accurate features are extracted and the accuracy of discrimination is promoted.",
        "keywords": [
            "morphological image analysis method",
            "mathematic morphological operation sequence",
            "operation sequence",
            "gray scale image",
            "binary image",
            "binary image analysis",
            "novel genetic programming algorithm",
            "original image",
            "image analysis",
            "gray scale image enhancement",
            "whole image",
            "corresponding goal image"
        ],
        "authors": [
            {
                "name": "Jun Wang",
                "org": "Key Laboratory of Machine Perception (Ministry of Education), Peking University, Department of Machine Intelligence, School of EECS, Peking University, P.R. China"
            },
            {
                "name": "Ying Tan",
                "org": "Key Laboratory of Machine Perception (Ministry of Education), Peking University, Department of Machine Intelligence, School of EECS, Peking University, P.R. China"
            }
        ],
        "venue": "ICSI (1)",
        "year": 2011
    },
    "53Wm0qaY": {
        "id": "53Wm0qaY",
        "title": "An adaptive staged PSO based on particles' search capabilities",
        "abstract": "This study proposes an adaptive staged particle swarm optimization (ASPSO) algorithm based on analyses of particles' search capabilities First, the search processes of the standard PSO (SPSO) and the linear decreasing inertia weight PSO (LDWPSO) are analyzed based on our previous definition of exploitation Second, three stages of the search process in PSO are defined Each stage has its own search preference, which is represented by the exploitation capability of swarm Third, the mapping between inertia weight, learning factor (w-c) and the exploitation capability is given At last, the ASPSO is proposed By setting different values of w-c in three stages, one can make swarm search the space with particular strategy in each stage, and the particles can be directed to find the solution more effectively The experimental results show that the proposed ASPSO has better performance than SPSO and LDWPSO on most of test functions.",
        "keywords": [
            "search capability",
            "proposed aspso",
            "particle swarm optimization",
            "swarm third",
            "inertia weight pso",
            "exploitation capability",
            "search process",
            "search capabilities first",
            "own search preference",
            "standard pso",
            "exploitation second",
            "performances"
        ],
        "authors": [
            {
                "name": "Kun Liu",
                "org": "Key laboratory of Machine Perception, Ministry of Education, Peking University, Beijing, China"
            },
            {
                "name": "Ying Tan",
                "org": "Key laboratory of Machine Perception, Ministry of Education, Peking University, Beijing, China"
            },
            {
                "name": "Xingui He",
                "org": "Key laboratory of Machine Perception, Ministry of Education, Peking University, Beijing, China"
            }
        ],
        "venue": "ICSI (1)",
        "year": 2010
    },
    "RVnLx991": {
        "id": "RVnLx991",
        "title": "Efficient Euclidean distance transform algorithm of binary images in arbitrary dimensions",
        "abstract": "In this paper, we propose an efficient algorithm, i.e., PBEDT, for short, to compute the exact Euclidean distance transform (EDT) of a binary image in arbitrary dimensions. The PBEDT is based on independent scan and implemented in a recursive way, i.e., the EDT of a d-dimensional image is able to be computed from the EDTs of its (d-1)-dimensional sub-images. In each recursion, all of the rows in the current dimensional direction are processed one by one. The points in the current processing row and their closest feature points in (d-1)-dimensional sub-images can be shown in a Euclidean plane. By using the geometric properties of the perpendicular bisector, the closest feature points of (d-1)-dimensional sub-images are easily verified so as to lead to the EDT of a d-dimensional image after eliminating the invalid points. The time complexity of the PBEDT algorithm is linear in the amount of both image points and dimensions with a small coefficient. Compared with the state-of-the-art EDT algorithms, the PBEDT algorithm is much faster and more stable in most cases.",
        "keywords": [
            "current dimensional direction",
            "d-dimensional image",
            "binary image",
            "euclidean plane",
            "closest feature point",
            "dimensional sub-images",
            "image point",
            "pbedt algorithm",
            "arbitrary dimension",
            "efficient algorithm",
            "state-of-the-art edt algorithm",
            "efficient euclidean distance"
        ],
        "authors": [
            {
                "name": "Jun Wang",
                "org": "Key Laboratory of Machine Perception (MOE), Peking University, China and Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, Beijing 1008 ..."
            },
            {
                "name": "Ying Tan",
                "org": "Key Laboratory of Machine Perception (MOE), Peking University, China and Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, Beijing 1008 ..."
            }
        ],
        "venue": "Pattern Recognition",
        "year": 2013
    },
    "gAeLrp1B": {
        "id": "gAeLrp1B",
        "title": "Advances in Swarm and Computational Intelligence: 6th International Conference, ICSI 2015 held in conjunction with the Second BRICS Congress, CCI 2015, Beijing, China, June 25-28, 2015, Proceedings, Part III",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ying tan",
                "org": ""
            },
            {
                "name": "yuhui shi",
                "org": ""
            },
            {
                "name": "fernando buarque",
                "org": ""
            },
            {
                "name": "alexander gelbukh",
                "org": ""
            },
            {
                "name": "swagatam das",
                "org": ""
            },
            {
                "name": "andries p engelbrecht",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2015
    },
    "DM1WWNSr": {
        "id": "DM1WWNSr",
        "title": "Nonlinear blind source separation using a genetic algorithm",
        "abstract": "",
        "keywords": [
            "blind source separation",
            "convergence rate",
            "genetic algorithm",
            "neural network"
        ],
        "authors": [
            {
                "name": "ying tan",
                "org": ""
            },
            {
                "name": "jun wang",
                "org": ""
            }
        ],
        "venue": "Reactive & Functional Polymers",
        "year": 2001
    },
    "eyrU1y3w": {
        "id": "eyrU1y3w",
        "title": "Proceedings of the Second international conference on Advances in swarm intelligence - Volume Part II",
        "abstract": "",
        "keywords": [
            "Second international conference",
            "swarm intelligence",
            "Volume Part",
            "Volume Part II"
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": "Peking University, Department of Machine Intelligence, Beijing, China"
            },
            {
                "name": "Yuhui Shi",
                "org": "Xi'an Jiaotong-Liverpool University, Department of Electrical and Electronic Engineering, Suzhou, China"
            },
            {
                "name": "Yi Chai",
                "org": "Chongqing University, Chongqing, China"
            },
            {
                "name": "Guoyin Wang",
                "org": "Chongqing University of Posts and Telecommunications, Chongqing, China"
            }
        ],
        "venue": "ICSI'11 Proceedings of the Second international conference on Advances in swarm intelligence - Volume Part II",
        "year": 2011
    },
    "8dfDMOHT": {
        "id": "8dfDMOHT",
        "title": "Introduction to Fireworks Algorithm",
        "abstract": "Inspired by fireworks explosion at night, conventional fireworks algorithm FWA was developed in 2010. Since then, several improvements and applications were proposed to improve the efficiency of FWA. In this paper, the conventional fireworks algorithm is first summarized and three improved fireworks algorithms are provided. By changing the ways of calculating the numbers and amplitudes of sparks in fireworks' explosion, the improved FWA algorithms become more reasonable and explainable. In addition, the multi-objective fireworks algorithm and the graphic processing unit GPU based fireworks algorithm are also presented, particularly the GPU based fireworks algorithm is able to speed up the optimization process considerably. Extensive experiments on 13 benchmark functions demonstrate that the three improved fireworks algorithms significantly increase the accuracy of found solutions, yet decrease the running time dramatically. At last, some applications of fireworks algorithm are briefly described, while its shortcomings and future research directions are identified.",
        "keywords": [
            "multi-objective fireworks algorithm",
            "benchmark function",
            "improved firework",
            "improved FWA",
            "conventional fireworks algorithm",
            "fireworks explosion",
            "Fireworks Algorithm",
            "extensive experiment",
            "fireworks algorithm",
            "conventional firework",
            "improved fireworks algorithm"
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": "School of Electronics Engineering and Computer Science, Peking University, Beijing, China"
            },
            {
                "name": "Chao Yu",
                "org": "School of Electronics Engineering and Computer Science, Peking University, Beijing, China"
            },
            {
                "name": "Shaoqiu Zheng",
                "org": "School of Electronics Engineering and Computer Science, Peking University, Beijing, China"
            },
            {
                "name": "Ke Ding",
                "org": "School of Electronics Engineering and Computer Science, Peking University, Beijing, China"
            }
        ],
        "venue": "IJSIR",
        "year": 2013
    },
    "S5qmKUfB": {
        "id": "S5qmKUfB",
        "title": "Orthogonal Quadratic Discriminant Functions for Face Recognition",
        "abstract": "Small sample size (SSS) problem is usually a limit to the robustness of learning methods in face recognition. Especially in the quadratic discriminant functions (QDF), too many parameters need to be estimated and covariance matrix of a class is usually singular. In order to overcome the SSS problems, we proposed a novel approach called orthogonal quadratic discriminant functions (OQDF). The OQDF assumes probability distribution functions of each two classes of face images have a uniform shape. Then, three OQDF models are developed. The Laplacian smoothing transform (LST) and Fisher's linear discriminant (FLD) are employed to preprocess the face images for the OQDF classifier. Finally, we evaluate our proposed algorithms on two face databases, ORL and Yale.",
        "keywords": [
            "face image",
            "orthogonal quadratic discriminant functions",
            "face databases",
            "face recognition",
            "orthogonal quadratic discriminant function",
            "linear discriminant",
            "oqdf model",
            "oqdf classifier",
            "sss problem",
            "proposed algorithm",
            "quadratic discriminant function",
            "probability distribution function",
            "discriminant function",
            "covariance matrix"
        ],
        "authors": [
            {
                "name": "Suicheng Gu",
                "org": "Key Laboratory of Machine Perception(MOE), Peking University/ Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, Beijing, P.R. China 100 ..."
            },
            {
                "name": "Ying Tan",
                "org": "Key Laboratory of Machine Perception(MOE), Peking University/ Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, Beijing, P.R. China 100 ..."
            },
            {
                "name": "Xingui He",
                "org": "Key Laboratory of Machine Perception(MOE), Peking University/ Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, Beijing, P.R. China 100 ..."
            }
        ],
        "venue": "ISNN (3)",
        "year": 2009
    },
    "QMYCxgRA": {
        "id": "QMYCxgRA",
        "title": "Hybrid particle swarm optimizer with advance and retreat strategy and clonal mechanism for global numerical optimization",
        "abstract": "A novel particle swarm optimization algorithm based on advance and retreat strategy and clone mechanism (ARC-PSO) is proposed in this paper. It is well known that the advance-and-retreat strategy is a simple and effective method of one-dimensional search. We use the advance-and-retreat strategy to endow the clones with faster speed to find nearby local basins before next clonal operation. Furthermore, in the next clonal operation, the search space is enlarged greatly and the diversity of clones is increased. When the fitness value turns better after last ldquoflyingrdquo, the cloned particle advances. On the contrary, the cloned particle retreats then searches in the reverse direction of the last ldquoflyingrdquo with a small step-size of the previous velocity. Thus, the swarm has strong optimization ability. Comparisons among the proposed ARC-PSO, the conventional standard particle swarm optimization (SPSO) and the pure clone particle swarm optimization (CPSO) on thirteen benchmark test functions are presented in this paper. Experimental results show that the proposed ARC-PSO is capable of speeding up the evolution process significantly and improving the performance of global optimizer greatly.",
        "keywords": [
            "clonal operation",
            "one-dimensional search",
            "global numerical optimization",
            "particle swarm optimisation",
            "search problems",
            "clone particle swarm optimization",
            "advance-and-retreat strategy",
            "particle swarm optimization algorithm",
            "clone mechanism",
            "hybrid particle swarm optimizer",
            "cloning",
            "search space",
            "convergence",
            "particle swarm optimization",
            "space exploration",
            "benchmark testing",
            "stochastic processes",
            "helium",
            "optimization",
            "history",
            "global optimization"
        ],
        "authors": [
            {
                "name": "Junqi Zhang",
                "org": ""
            },
            {
                "name": "Zhongmin Xiao",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Xingui He",
                "org": ""
            }
        ],
        "venue": "IEEE Congress on Evolutionary Computation",
        "year": 2008
    },
    "iefSW8jU": {
        "id": "iefSW8jU",
        "title": "Genetic Algorithm for Context-Aware Service Composition Based on Context Space Model",
        "abstract": "The emergence of Web services has changed the Internet a lot, and greatly facilitated the development of service based software systems. How to select appropriate services and compose them according to given context to satisfy a user's requirement is a big challenge. This paper proposes a novel Genetic Algorithm (GA) method to synthesis web services in a context-aware environment. We first present a context space model to illustrate both contexts and services in a formal way, we utilize GA to compose context-aware services according to users' preference. We transform the problem of service composition to a multi-objective optimization problem. To resolve the conflict and dependencies among services in GA process, we propose a service similarity tree (SST) model to measure the similarity between services. Finally, we design a simulation experiment to evaluate our method. The experiment result shows that our method is a promising one to solve service composition problem in a context-aware environment.",
        "keywords": [
            "context-aware service composition",
            "genetic algorithm",
            "context space model",
            "appropriate service",
            "web service",
            "service composition",
            "context-aware service",
            "multi-objective optimization problem",
            "ga process",
            "service similarity tree",
            "service composition problem",
            "synthesis web service",
            "context-aware environment",
            "ubiquitous computing",
            "genetic algorithms",
            "web services"
        ],
        "authors": [
            {
                "name": "Zhichao Zhang",
                "org": ""
            },
            {
                "name": "Shaoqiu Zheng",
                "org": ""
            },
            {
                "name": "Weiping Li",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Zhonghai Wu",
                "org": ""
            },
            {
                "name": "Wei Tan",
                "org": ""
            }
        ],
        "venue": "ICWS",
        "year": 2013
    },
    "HWUqbi4I": {
        "id": "HWUqbi4I",
        "title": "Artificial immune system based methods for spam filtering.",
        "abstract": "To solve the spam problem, many statistical learning methods and AIS methods have been proposed and applied. In essence, statistical learning methods and AIS methods have quite different origins, and they try to find the solutions from distinct aspects. In recent works, we proposed several hybrid methods, which combined immune theory with statistical methods in spam filtering. In this paper, we briefly review and analyze these works and possible extensions, and demonstrate the rationality of building hybrid immune models for spam filtering. In addition, a generic framework of an immune based model is presented, and online implementation strategies are given. It is well demonstrated that how to apply the immune based model to building an intelligent email server. \u00a9 2013 IEEE.",
        "keywords": [
            "detectors",
            "support vector machines",
            "feature extraction",
            "immune system",
            "computational modeling",
            "artificial immune systems",
            "artificial immune system"
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Guyue Mi",
                "org": ""
            },
            {
                "name": "Yuanchun Zhu",
                "org": ""
            },
            {
                "name": "Chao Deng",
                "org": ""
            }
        ],
        "venue": "ISCAS",
        "year": 2013
    },
    "Hc10KjII": {
        "id": "Hc10KjII",
        "title": "A Torque Control Strategy with Charge Buffer for Parallel Hybrid Electric Vehicle",
        "abstract": "As a new kind of vehicles with low fuel cost and low emission, hybrid electric vehicle (HEV) has been given more and more attention in recent years. The key technique in the HEV is the optimal control strategy for the best performance. This paper proposed a new torque control strategy with charge buffer (TCSCB) to control the two power sources of the HEV. The TCSCB is based on the control of engine torque which make the control strategy easily distribute the output power to the engine and motor. In this control strategy, the real time optimization based on the engine efficiency map increases engine efficiency observably. The charge buffer reduces the dramatic fluctuation of the engine torque to improve the fuel economy. The prediction engine torque based on the neural network improves the control performance by the future information greatly. The simulation results showed the TCSCB could reach a higher fuel economy and lower emission compared to the current control strategies. In order to optimize the control performances, the parameters in the TCSCB were also discussed in details.",
        "keywords": [
            "neural network",
            "power control",
            "optimal control",
            "torque control",
            "hybrid electric vehicles",
            "engine torque",
            "parallel hybrid electric vehicle",
            "engines",
            "charge buffer",
            "optimal control strategy",
            "fuel economy",
            "neural nets",
            "engine efficiency map",
            "artificial neural networks",
            "thyristors",
            "system on a chip",
            "torque"
        ],
        "authors": [
            {
                "name": "Xi Huang",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Xingui He",
                "org": ""
            }
        ],
        "venue": "VTC Fall",
        "year": 2010
    },
    "xVvMEMXt": {
        "id": "xVvMEMXt",
        "title": "Analysis on global convergence and time complexity of fireworks algorithm",
        "abstract": "Fireworks Algorithm (FWA) is a new proposed optimization technique based on swarm intelligence. In FWA, the algorithm generates the explosion sparks and Gaussian mutation sparks by the explosion operator and Gaussian mutation operator to search the global optimum in the problem space. FWA has been applied in various fields of practical optimization problems and gains great success. However, its convergence property has not been analyzed since it has been provided. Same as other swarm intelligence (SI) algorithms, the optimization process of FWA is able to be considered as a Markov process. In this paper, a Markov stochastic process on FWA has been defined, and is used to prove the global convergence of FWA while analyzing its time complexity. In addition, the computation of the approximation region of expected convergence time of FWA has also been given.",
        "keywords": [
            "gaussian mutation sparks",
            "optimisation",
            "time complexity",
            "fwa",
            "explosion sparks",
            "problem space",
            "convergence property",
            "gaussian mutation operator",
            "convergence",
            "computational complexity",
            "markov stochastic process",
            "explosion operator",
            "global convergence analysis",
            "gaussian processes",
            "fireworks algorithm",
            "si algorithm",
            "markov processes",
            "global optimum",
            "swarm intelligence",
            "optimization technique",
            "optimization"
        ],
        "authors": [
            {
                "name": "Jianhua Liu",
                "org": "Sch. of Inf. Sci. & Eng., Fujian Univ. of Technol., Fuzhou, China|c|"
            },
            {
                "name": "Shaoqiu Zheng",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            }
        ],
        "venue": "IEEE Congress on Evolutionary Computation",
        "year": 2014
    },
    "wiYRxQHH": {
        "id": "wiYRxQHH",
        "title": "Feature construction approach for email categorization based on term space partition",
        "abstract": "This paper proposes a novel feature construction approach based on term space partition (TSP) aiming to establish a mechanism to make terms play more sufficient and rational roles in email categorization. Dominant terms and general terms are separated by performing a vertical partition of the original term space with respect to feature selection metrics, while spam terms and ham terms are separated by a transverse partition with respect to class tendency. Strategies for constructing discriminative features, named term ratio and term density, are designed on corresponding subspaces. Motivation and principle of the TSP approach is presented in detail, as well as the implementation. Experiments are conducted on five benchmark corpora using cross-validation to evaluate the proposed TSP approach. Comprehensive experimental results suggest that the TSP approach far outperforms the traditional and most widely used feature construction approach in spam filtering, which is named bag-of-words, in both performance and efficiency. In comparison with the heuristic and state-of-the-art approaches, namely CFC and LC, the proposed TSP approach shows obvious advantage in terms of accuracy and \u03bc1 measure, as well as high precision, which is warmly welcomed in real spam filtering. Furthermore, the TSP approach performs quite similar with CFC in efficiency of processing incoming emails, while much faster than LC. In addition, it is shown that the TSP approach cooperates well with both unsupervised and supervised feature selection metrics, which endows it with flexible capability in the real world.",
        "keywords": [
            "cfc",
            "e-mail filters",
            "email categorization",
            "term space partition",
            "term ratio",
            "tsp",
            "supervised feature selection metrics",
            "pattern classification",
            "concentration based feature construction",
            "unsolicited e-mail",
            "ham terms",
            "term density",
            "lc",
            "spam filtering",
            "transverse partition",
            "local-concentration",
            "bag-of-words",
            "feature selection",
            "spam terms",
            "discriminative features",
            "feature selection metrics",
            "unsupervised feature selection metrics"
        ],
        "authors": [
            {
                "name": "Guyue Mi",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Pengtao Zhang",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Ying Tan",
                "org": "Peking University(Peking University),Beijing,China"
            }
        ],
        "venue": "IJCNN",
        "year": 2013
    },
    "6D7Gytu8": {
        "id": "6D7Gytu8",
        "title": "A three-layer back-propagation neural network for spam detection using artificial immune concentration",
        "abstract": "In this paper, a three-layer back-propagation neural network (BPNN) is employed for spam detection by using a concentration based feature construction (CFC) approach. In the CFC approach, `self' and `non-self' concentrations are constructed through `self' and `non-self' gene libraries, respectively, to form a two-element concentration vector for expressing the e-mail efficiently. A three-layer BPNN with two-element input is then employed to classify e-mails automatically. Comprehensive experiments are conducted on two public benchmark corpora PU1 and Ling to demonstrate that the proposed CFC approach based BPNN classifier not only has a very much fast speed but also achieves 97 and 99% of classification accuracy on corpora PU1 and Ling by just using a two-element concentration feature vector.",
        "keywords": [
            "cfc approach",
            "neural networks",
            "two-element input",
            "spam detectionfeature construction \ufffd concentrationartificial immune system \ufffd neural networks",
            "three-layer bpnn",
            "bpnn classifier",
            "concentration",
            "proposed cfc approach",
            "spam detection",
            "two-element concentration feature vector",
            "three-layer back-propagation neural network",
            "feature construction",
            "classification accuracy",
            "artificial immune system",
            "two-element concentration vector",
            "artificial immune concentration",
            "immune system",
            "neural network",
            "feature vector"
        ],
        "authors": [
            {
                "name": "Guangchen Ruan",
                "org": "Peking University, Key Laboratory of Machine Perception (MOE), Department of Machine Intelligence, School of Electronics Engineering and Computer Science, 100871, Beijing, China"
            },
            {
                "name": "Ying Tan",
                "org": "Peking University, Key Laboratory of Machine Perception (MOE), Department of Machine Intelligence, School of Electronics Engineering and Computer Science, 100871, Beijing, China"
            }
        ],
        "venue": "Soft Comput.",
        "year": 2010
    },
    "8RLvpUlO": {
        "id": "8RLvpUlO",
        "title": "Particle swarm optimization with triggered mutation and its implementation based on GPU",
        "abstract": "A novel particle swarm optimization with triggered mutation (PSO-TM) is presented in this paper for better performance. First, a technique is designed to evaluate the \"health\" of swarm. When the swarm is successively \"unhealthy\" for a certain number of iterations, uniform mutation is applied to the position of each particle in a probabilistic way. If the mutations produce worse particles, the memorized previous positions are retrieved as current positions of these particles, hence the normal evolution process of the swarm will not be fiercely interrupted by such bad mutations. Experiments are conducted on 29 benchmark test functions to show the promising performance of our proposed PSOTM. The results show that the PSO-TM performs much better than the standard PSO on almost all of the 29 test functions, especially those multimodal, complex ones of hybrid composition. Besides, PSO-TM adds little computation complexity to the standard PSO, and runs almost equally fast. Furthermore, we have implemented PSO-TM based on Graphic Processing Unit(GPU) in parallel. Compared with the CPU-based standard PSO, the proposed PSO-TM can reach a speedup of 25\u00d7, as well as an improved optimizing performance.",
        "keywords": [
            "bad mutation",
            "promising performance",
            "triggered mutation",
            "benchmark test function",
            "cpu-based standard pso",
            "proposed pso-tm",
            "improved optimizing performance",
            "proposed psotm",
            "standard pso",
            "better performance",
            "novel particle swarm optimization",
            "speedup",
            "particle swarm optimization",
            "mutation",
            "computational complexity"
        ],
        "authors": [
            {
                "name": "You Zhou",
                "org": "Peking University, Beijing, China"
            },
            {
                "name": "Ying Tan",
                "org": "Peking University, Beijing, China"
            }
        ],
        "venue": "GECCO",
        "year": 2010
    },
    "NxIwxhwo": {
        "id": "NxIwxhwo",
        "title": "Proceedings of the First international conference on Advances in Swarm Intelligence - Volume Part I",
        "abstract": "",
        "keywords": [
            "Volume Part",
            "Volume Part II",
            "First international conference",
            "Swarm Intelligence"
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": "Key Laboratory of Machine Perception (MOE), Department of Machine Intelligence, Peking University, Beijing, China"
            },
            {
                "name": "Yuhui Shi",
                "org": "Research and Postgraduate Office, Xi'an Jiaotong-Liverpool University, Suzhoum, China"
            },
            {
                "name": "Kay Chen Tan",
                "org": "Department of Electrical and Computer Engineering, National University of Singapore, Engineering Drive 3, 4 Engineering Drive 3, Suzhoum, Singapore"
            }
        ],
        "venue": "ICSI'10 Proceedings of the First international conference on Advances in Swarm Intelligence - Volume Part I",
        "year": 2010
    },
    "xH3xKkyh": {
        "id": "xH3xKkyh",
        "title": "Parallel Particle Swarm Optimization Algorithm Based on Graphic Processing Units",
        "abstract": "\n A novel parallel approach to implement particle swarm optimization(PSO) algorithm on graphic processing units(GPU) in a personal\n computer is proposed in this chapter. By using the general-purpose computing ability of GPU and under the software platform\n of compute unified device architecture(CUDA) which is developed by NVIDIA, the PSO algorithm can be executed in parallel on\n the GPU. The process of fitness evaluation, as well as the updating of the velocity and the position of all the particles\n in the swarm are parallelized and described in details in the context of this chapter. Experiments are conducted by running\n the PSO both on the GPU and the CPU, respectively, to optimize several benchmark test functions. The running time of the PSO\n based on GPU(GPU-PSO, for short) is greatly shortened compared to that of the PSO based on CPU(CPU-PSO, for short). A 40\u00d7 speedup can be obtained by our implemented GPU-PSO on a display card of NVIDIA Geforce 9800GT, with the same optimizing\n performance. Compared to the CPU-PSO, the GPU-PSO has special speed advantages on large-scale population and high-dimensional\n problems which are often happened and widely used in a lot of real-world optimization applications.\n \n ",
        "keywords": [
            "particle swarm optimization",
            "cuda.",
            "parallelization",
            "graphic processing units"
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": "Key Laboratory of Machine Perception (MOE), Peking University, P.R. China"
            },
            {
                "name": "You Zhou",
                "org": "Key Laboratory of Machine Perception (MOE), Peking University, P.R. China"
            }
        ],
        "venue": "",
        "year": 2011
    },
    "9rizZ5ap": {
        "id": "9rizZ5ap",
        "title": "Adaptive Fireworks Algorithm",
        "abstract": "In this paper, firstly, the amplitude used in the Enhanced Fireworks Algorithm (EFWA) is analyzed and its lack of adaptability is revealed, and then the adaptive amplitude method is proposed where amplitude is calculated according to the already evaluated fitness of the individuals adaptively. Finally, the Adaptive Fireworks Algorithm (AFWA) is proposed, replacing the amplitude operator in EFWA with the new adaptive amplitude. Some theoretical analyses are made to prove the adaptive explosion amplitude a promising method. Experiments on CEC13's 28 benchmark functions are also conducted in order to illustrate the performance and it turns out that the AFWA where adaptive amplitude is adopted outperforms significantly the EFWA and meanwhile the time consumed is not longer. Moreover, according to experimental results, AFWA performs better than the Standard Particle Swarm Optimization (SPSO).",
        "keywords": [
            "spso",
            "adaptive fireworks algorithm",
            "evolutionary computation",
            "particle swarm optimisation",
            "efwa",
            "adaptive amplitude",
            "amplitude operator",
            "enhanced fireworks algorithm",
            "standard particle swarm optimization",
            "cec13",
            "afwa",
            "upper bound",
            "algorithm design and analysis",
            "nickel",
            "next generation networking"
        ],
        "authors": [
            {
                "name": "Junzhi Li",
                "org": "Dept. of Machine Intell., Peking Univ., Beijing, China|c|"
            },
            {
                "name": "Shaoqiu Zheng",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            }
        ],
        "venue": "IEEE Congress on Evolutionary Computation",
        "year": 2014
    },
    "6MiIokF0": {
        "id": "6MiIokF0",
        "title": "Uninterrupted Approaches for Spam Detection Based on SVM and AIS",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ying tan",
                "org": ""
            },
            {
                "name": "guangchen ruan",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "Bh8FMcAk": {
        "id": "Bh8FMcAk",
        "title": "Neural network realization of support vector methods for pattern classification",
        "abstract": "We apply a recurrent neural network to support vector machine (SVM) training for pattern recognition. Specifically, a primal-dual neural network is exploited to solve the quadratic programming problem encountered in training SVMs. The properties of the network allow one to design SVMs without adjustable network parameters and give a better solution for ill-posed problems",
        "keywords": [
            "neural network",
            "pattern recognition",
            "quadratic programming",
            "primal-dual neural network",
            "learning (artificial intelligence)",
            "neural network realization",
            "pattern classification",
            "support vector methods",
            "training dataset",
            "support vector machine",
            "training support vector machine",
            "training svms",
            "recurrent neural nets",
            "recurrent neural network",
            "svm training",
            "new neural network svm",
            "learning",
            "training problem",
            "quadratic programming problem",
            "automation",
            "neural networks",
            "information science",
            "support vector machines",
            "recurrent neural networks",
            "quadratic program",
            "learning artificial intelligence",
            "error correction"
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": "Dept. of Electron. Eng. & Inf. Sci., Univ. of Sci. & Technol. of China, Hefei, China|c|"
            },
            {
                "name": "Youshen Xia",
                "org": ""
            },
            {
                "name": "Jun Wang",
                "org": ""
            }
        ],
        "venue": "IJCNN (6)",
        "year": 2000
    },
    "KzYMYci9": {
        "id": "KzYMYci9",
        "title": "Iterative improvement of the Multiplicative Update NMF algorithm using nature-inspired optimization.",
        "abstract": "Low-rank approximations of data (e. g. based on the Singular Value Decomposition) have proven very useful in various data mining applications. The Non-negative Matrix Factorization (NMF) leads to special low-rank approximations which satisfy non-negativity constraints. The Multiplicative Update (MU) algorithm is one of the two original NMF algorithms and is still one of the fastest NMF algorithms per iteration. Nevertheless, MU demands a quite large number of iterations in order to provide an accurate approximation of the original data. In this paper we present a new iterative update strategy for the MU algorithm based on nature-inspired optimization algorithms. The goal is to achieve a better accuracy per runtime compared to the standard version of MU. Several properties of the NMF objective function underlying the MU algorithm motivate the utilization of heuristic search algorithms. Indeed, this function is usually non-differentiable, discontinuous, and may possess many local minima. Experimental results show that our new iterative update strategy for the MU algorithm achieves the same approximation error than the standard version in significantly fewer iterations and in faster overall runtime. \u00a9 2011 IEEE.",
        "keywords": [
            "heuristic search",
            "objective function",
            "approximation theory",
            "iterative methods",
            "non negative matrix factorization",
            "singular value decomposition",
            "local minima",
            "satisfiability",
            "low rank approximation",
            "matrix decomposition",
            "data mining",
            "approximation error",
            "nonnegative matrix factorization"
        ],
        "authors": [
            {
                "name": "Andreas Janecek",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            }
        ],
        "venue": "ICNC",
        "year": 2011
    },
    "W1ojoJ7o": {
        "id": "W1ojoJ7o",
        "title": "A danger feature based negative selection algorithm",
        "abstract": "This paper proposes a danger feature based negative selection algorithm (DFNSA). The DFNSA divides the danger feature space into four parts, and reserves the information of danger features to the utmost extent, laying a good foundation for measuring the danger of a sample. In order to incorporate the DFNSA into the procedure of malware detection, a DFNSA-based malware detection (DFNSA-MD) model is proposed. It maps a sample into the whole danger feature space by using the DFNSA. The danger of a sample is measured precisely in this way and used to classify the sample. Eight groups of experiments on three public malware datasets are exploited to evaluate the effectiveness of the proposed DFNSA-MD model using cross validation. Comprehensive experimental results suggest that the DFNSA is able to reserve as much information of danger features as possible, and the DFNSA-MD model is effective to detect unseen malware. It outperforms the traditional negative selection algorithm based and the negative selection algorithm with penalty factor based malware detection models in all the experiments for about 5.34% and 0.67% on average, respectively.",
        "keywords": [
            "malware detection",
            "public malware datasets",
            "dfnsa-based malware detection",
            "unseen malware",
            "danger feature space",
            "negative selection algorithm",
            "malware detection model",
            "danger feature",
            "dfnsa-md model",
            "whole danger feature space",
            "artificial immune system",
            "feature extraction"
        ],
        "authors": [
            {
                "name": "Pengtao Zhang",
                "org": "Key Laboratory of Machine Perception (MOE), Peking University, Beijing, China,Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, Beijing ..."
            },
            {
                "name": "Ying Tan",
                "org": "Key Laboratory of Machine Perception (MOE), Peking University, Beijing, China,Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, Beijing ..."
            }
        ],
        "venue": "ICSI (1)",
        "year": 2012
    },
    "CUu0KwYR": {
        "id": "CUu0KwYR",
        "title": "Proceedings of the Third international conference on Advances in Swarm Intelligence - Volume Part I",
        "abstract": "",
        "keywords": [
            "volume part",
            "volume part ii",
            "third international conference",
            "swarm intelligence"
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": "Key Laboratory of Machine Perception (MOE), Peking University, Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, Beijing, China"
            },
            {
                "name": "Yuhui Shi",
                "org": "Department of Electrical and Electronic Engineering, Xi'an Jiaotong-Liverpool University, Suzhou, China"
            },
            {
                "name": "Zhen Ji",
                "org": "Shenzhen City Key Laboratory of Embedded System Design, College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China"
            }
        ],
        "venue": "ICSI'12 Proceedings of the Third international conference on Advances in Swarm Intelligence - Volume Part I",
        "year": 2012
    },
    "KfLAY6IY": {
        "id": "KfLAY6IY",
        "title": "Dynamic search in fireworks algorithm",
        "abstract": "We propose an improved version of the recently developed Enhanced Fireworks Algorithm (EFWA) based on an adaptive dynamic local search mechanism. In EFWA, the explosion amplitude (i.e., search area around the current location) of each firework is computed based on the quality of the firework's current location. This explosion amplitude is limited by a lower bound which decreases with the number of iterations in order to avoid the explosion amplitude to be [close to] zero, and in order to enhance global search abilities at the beginning and local search abilities towards the later phase of the algorithm. As the explosion amplitude in EFWA depends solely on the fireworks' fitness and the current number of iterations, this procedure does not allow for an adaptive optimization process. To deal with these limitations, we propose the Dynamic Search Fireworks Algorithm (dynFWA) which uses a dynamic explosion amplitude for the firework at the currently best position. If the fitness of the best firework could be improved, the explosion amplitude will increase in order to speed up convergence. On the contrary, if the current position of the best firework could not be improved, the explosion amplitude will decrease in order to narrow the search area. In addition, we show that one of the EFWA operators can be removed in dynFWA without a loss in accuracy - this makes dynFWA computationally more efficient than EFWA. Experiments on 28 benchmark functions indicate that dynFWA is able to significantly outperform EFWA, and achieves better performance than the latest SPSO version SPSO2011.",
        "keywords": [
            "evolutionary computation",
            "global search abilities",
            "efwa",
            "local search abilities",
            "adaptive dynamic local search mechanism",
            "search problems",
            "convergence",
            "explosion amplitude",
            "adaptive optimization process",
            "spso2011",
            "enhanced fireworks algorithm",
            "dynamic search fireworks algorithm",
            "dynfwa",
            "iterations",
            "optimization",
            "sociology",
            "statistics"
        ],
        "authors": [
            {
                "name": "Shaoqiu Zheng",
                "org": "Dept. of Machine Intell., Peking Univ., Beijing, China|c|"
            },
            {
                "name": "Andreas Janecek",
                "org": ""
            },
            {
                "name": "Junzhi Li",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            }
        ],
        "venue": "IEEE Congress on Evolutionary Computation",
        "year": 2014
    },
    "yKURTsoB": {
        "id": "yKURTsoB",
        "title": "Fireworks algorithm with differential mutation for solving the CEC 2014 competition problems",
        "abstract": "The idea of fireworks algorithm (FWA) is inspired by the fireworks explosion in the sky at night. When a firework explodes, a shower of sparks appear around it. In this way, the adjacent area of the firework is searched. By controlling the amplitude of the explosion, the ability of local search for FWA is guaranteed. The way of fireworks algorithm searching the surrounding area can be further improved by differential mutation operator, forming an algorithm called FWA-DM. In this paper, the benchmark suite in the competition of congress of evolutionary computation (CEC) 2014 is used to test the performance of FWA-DM.",
        "keywords": [
            "congress of evolutionary computation",
            "evolutionary computation",
            "fireworks algorithm",
            "differential mutation operator",
            "cec 2014 competition problems",
            "fwa-dm algorithm",
            "fwa local search",
            "sociology",
            "statistics",
            "particle swarm optimization",
            "optimization",
            "benchmark testing"
        ],
        "authors": [
            {
                "name": "Chao Yu",
                "org": "Dept. of Machine Intell., Peking Univ., Beijing, China|c|"
            },
            {
                "name": "Lingchen Kelley",
                "org": ""
            },
            {
                "name": "Shaoqiu Zheng",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            }
        ],
        "venue": "IEEE Congress on Evolutionary Computation",
        "year": 2014
    },
    "ewQpyJvz": {
        "id": "ewQpyJvz",
        "title": "Recentness biased learning for time series forecasting",
        "abstract": "In recent years, dynamic time series analysis with the concept drift has become an important and challenging task for a wide range of applications including stock price forecasting, target sales, etc. In this paper, a recentness biased learning method is proposed for dynamic time series analysis by introducing a drift factor. First of all, the recentness biased learning method is derived by minimizing the forecasting risk based on a priori probabilistic model where the latest sample is weighted most. Secondly, the recentness biased learning method is implemented with an autoregressive process and the multi-layer feed-forward neural networks. The experimental results have been discussed and analyzed in detail for two typical databases. It is concluded that the proposed model has a high accuracy in time series forecasting.",
        "keywords": [
            "challenging task",
            "stock price forecasting",
            "concept drift",
            "time series forecasting",
            "drift factor",
            "forecasting risk",
            "autoregressive process",
            "dynamic time series analysis"
        ],
        "authors": [
            {
                "name": "Suicheng Gu",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Xingui He",
                "org": ""
            }
        ],
        "venue": "Inf. Sci.",
        "year": 2013
    },
    "CGe69Vfl": {
        "id": "CGe69Vfl",
        "title": "A multi-resolution-concentration based feature construction approach for spam filtering",
        "abstract": "This paper proposes a multi-resolution-concentration (MRC) based feature construction approach for spam filtering by progressively partitioning an email into local areas on smaller and smaller resolutions. The MRC approach depicts a dynamic process of gradual refinement in locating the pathogens by calculating concentrations of detectors on local areas, and is considered to be able to extract the position-correlated and process-correlated information from emails. Furthermore, A weighted MRC (WMRC) approach is presented by considering the different activity levels of detectors in calculation of concentrations. A generic structure of the MRC model, which mainly contains detector sets construction and multi-resolution concentrations calculation, is designed. The implementations of MRC and WMRC approaches are described in detail. Experiments are conducted on five benchmark corpora using cross-validation to evaluate the proposed MRC model. Comprehensive experimental results suggest that the MRC and WMRC approaches perform far better than the prevalent bag-of-words approach in both performance and efficiency. Compared with the concentration based feature construction approach and local-concentration based feature extraction approach, MRC and WMRC achieve higher accuracy and \u03bc1 measure, which demonstrates the effectiveness of the MRC model. In addition, it is shown that both the MRC and WMRC approaches cooperate well with variety of classification methods, which endows the MRC model with flexible capability in the real world.",
        "keywords": [
            "e-mail filters",
            "feature construction approach",
            "multiresolution-concentration",
            "email",
            "information filtering",
            "unsolicited e-mail",
            "spam filtering",
            "mrc model",
            "position-correlated information extraction",
            "feature extraction",
            "gradual refinement",
            "process-correlated information extraction"
        ],
        "authors": [
            {
                "name": "Guyue Mi",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Pengtao Zhang",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Ying Tan",
                "org": "Peking University(Peking University),Beijing,China"
            }
        ],
        "venue": "IJCNN",
        "year": 2013
    },
    "zIhwkCZQ": {
        "id": "zIhwkCZQ",
        "title": "A unified distance measure scheme for orientation coding in identification",
        "abstract": "",
        "keywords": [
            "feature extraction",
            "identification",
            "evolutionary computation"
        ],
        "authors": [
            {
                "name": "shaoqiu zheng",
                "org": "peking university"
            },
            {
                "name": "ying tan",
                "org": "peking university"
            }
        ],
        "venue": "",
        "year": 2013
    },
    "474trS3v": {
        "id": "474trS3v",
        "title": "An immune concentration based virus detection approach using particle swarm optimization",
        "abstract": "This paper proposes an immune concentration based virus detection approach which utilizes a two-element concentration vector to construct the feature In this approach, \u2018self' and \u2018nonself' concentrations are extracted through \u2018self' and \u2018nonself' detector libraries, respectively, to form a vector with two elements of concentrations for characterizing the program efficiently and fast Several classifiers including k-nearest neighbor (KNN), RBF neural network and support vector machine (SVM) with this vector as input are then employed to classify the programs The selection of detector library determinant and parameters associated with a certain classifier is here considered as an optimization problem aiming at maximizing the accuracy of classification A clonal particle swarm optimization (CPSO) algorithm is used for this purpose Experimental results demonstrate that the proposed approach not only has a very much fast speed but also gives around 98% of accuracy under optimum conditions.",
        "keywords": [
            "support vector machine",
            "immune concentration",
            "fast speed",
            "two-element concentration vector",
            "detector library determinant",
            "virus detection approach",
            "optimization problem",
            "clonal particle swarm optimization",
            "detector library",
            "k nearest neighbor"
        ],
        "authors": [
            {
                "name": "Wei Wang",
                "org": ",Key Laboratory of Machine Perception, Ministry of Eduction, Peking University"
            },
            {
                "name": "Pengtao Zhang",
                "org": ",Key Laboratory of Machine Perception, Ministry of Eduction, Peking University"
            },
            {
                "name": "Ying Tan",
                "org": ",Key Laboratory of Machine Perception, Ministry of Eduction, Peking University"
            }
        ],
        "venue": "ICSI (1)",
        "year": 2010
    },
    "s2wlYtYw": {
        "id": "s2wlYtYw",
        "title": "Nonlinear blind source separation using a radial basis function network.",
        "abstract": "This paper proposes a novel neural-network approach to blind source separation in nonlinear mixture. The approach utilizes a radial basis function (RBF) neural-network to approximate the inverse of the nonlinear mixing mapping which is assumed to exist and able to be approximated using an RBF network. A contrast function which consists of the mutual information and partial moments of the outputs of the separation system, is defined to separate the nonlinear mixture. The minimization of the contrast function results in the independence of the outputs with desirable moments such that the original sources are separated properly. Two learning algorithms for the parametric RBF network are developed by using the stochastic gradient descent method and an unsupervised clustering method. By virtue of the RBF neural network, this proposed approach takes advantage of high learning convergence rate of weights in the hidden layer and output layer, natural unsupervised learning characteristics, modular structure, and universal approximation capability. Simulation results are presented to demonstrate the feasibility, robustness, and computability of the proposed method.",
        "keywords": [
            "nonlinear blind source separation",
            "robustness",
            "radial basis function networks",
            "pattern clustering",
            "weight learning convergence rate",
            "stochastic gradient descent method",
            "signal processing",
            "learning (artificial intelligence)",
            "universal approximation capability",
            "contrast function result",
            "nonlinear mixture",
            "modular structure",
            "rbf network",
            "convergence",
            "unsupervised learning.",
            "computability",
            "index terms\u2014blind source separation",
            "radial basis function network",
            "rbf neural network",
            "contrast function minimization",
            "natural unsupervised learning characteristics",
            "gradient methods",
            "nonlinear mixture separation",
            "nonlinear mixtures",
            "natural unsupervised learning characteristic",
            "nonlinear mixing mapping inverse approximation",
            "novel neural-network approach",
            "parametric rbf network",
            "unsupervised clustering method",
            "statistical indepen- dence",
            "radial basis function rbf neural networks",
            "minimisation",
            "contrast function",
            "feasibility",
            "unsupervised learning",
            "rbf neural-network",
            "learning algorithm",
            "stochastic gradient descent",
            "neural networks",
            "radial basis function",
            "stochastic processes",
            "indexing terms",
            "mutual information",
            "learning artificial intelligence",
            "computational modeling",
            "blind source separation",
            "convergence rate",
            "neural network",
            "clustering algorithms"
        ],
        "authors": [
            {
                "name": "Y Tan",
                "org": "Dept. of Electron. Eng. & Inf. Sci., Univ. of Sci. & Technol. of China, Hefei"
            },
            {
                "name": "J Wang",
                "org": ""
            },
            {
                "name": "J M Zurada",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Neural Networks",
        "year": 2001
    },
    "NUMuXvIi": {
        "id": "NUMuXvIi",
        "title": "Accelerating the Fireworks Algorithm with an Estimated Convergence Point.",
        "abstract": "We propose an acceleration method for the fireworks algorithms which uses a convergence point for the population estimated from moving vectors between parent individuals and their sparks. To improve the accuracy of the estimated convergence point, we propose a new type of firework, the synthetic firework, to obtain the correct of the local/global optimum in its local area\u2019s fitness landscape. The synthetic firework is calculated by the weighting moving vectors between a firework and each of its sparks. Then, they are used to estimate a convergence point which may replace the worst firework individual in the next generation. We design a controlled experiment for evaluating the proposed strategy and apply it to 20 CEC2013 benchmark functions of 2-dimensions (2-D), 10-D and 30-D with 30 trial runs each. The experimental results and the Wilcoxon signed-rank test confirm that the proposed method can significantly improve the performance of the canonical firework algorithm.",
        "keywords": "",
        "authors": [
            {
                "name": "Jun Yu",
                "org": "Kyushu University"
            },
            {
                "name": "Hideyuki Takagi",
                "org": "Kyushu University"
            },
            {
                "name": "Ying Tan",
                "org": ""
            }
        ],
        "venue": "ICSI",
        "year": 2018
    },
    "BpbdYlpb": {
        "id": "BpbdYlpb",
        "title": "Animmune local concentration based virus detection approach",
        "abstract": "Along with the evolution of computer viruses, the number of file samples that need to be analyzed has constantly increased.\n An automatic and robust tool is needed to classify the file samples quickly and efficiently. Inspired by the human immune\n system, we developed a local concentration based virus detection method, which connects a certain number of two-element local\n concentration vectors as a feature vector. In contrast to the existing data mining techniques, the new method does not remember\n exact file content for virus detection, but uses a non-signature paradigm, such that it can detect some previously unknown\n viruses and overcome the techniques like obfuscation to bypass signatures. This model first extracts the viral tendency of\n each fragment and identifies a set of statical structural detectors, and then uses an information-theoretic preprocessing\n to remove redundancy in the detectors\u2019 set to generate \u2018self\u2019 and \u2018nonself\u2019 detector libraries. Finally, \u2018self\u2019 and \u2018nonself\u2019\n local concentrations are constructed by using the libraries, to form a vector with an array of two elements of local concentrations\n for detecting viruses efficiently. Several standard data mining classifiers, including K-nearest neighbor (KNN), radial basis function (RBF) neural networks, and support vector machine (SVM), are leveraged to classify\n the local concentration vector as the feature of a benign or malicious program and to verify the effectiveness and robustness\n of this approach. Experimental results show that the proposed approach not only has a much faster speed, but also gives around\n 98% of accuracy.",
        "keywords": [
            "Artificial immune system",
            "Local concentration",
            "Virus detection"
        ],
        "authors": [
            {
                "name": "Wei Wang",
                "org": "MOE Key Laboratory of Machine Perception, Peking University, Beijing, 100871 China"
            },
            {
                "name": "Peng-tao Zhang",
                "org": "MOE Key Laboratory of Machine Perception, Peking University, Beijing, 100871 China"
            },
            {
                "name": "Ying Tan",
                "org": "MOE Key Laboratory of Machine Perception, Peking University, Beijing, 100871 China"
            },
            {
                "name": "Xin-gui He",
                "org": "MOE Key Laboratory of Machine Perception, Peking University, Beijing, 100871 China"
            }
        ],
        "venue": "Journal of Zhejiang University: Science C",
        "year": 2011
    },
    "bQWhRRNU": {
        "id": "bQWhRRNU",
        "title": "The Improvement on Controlling Exploration and Exploitation of Firework Algorithm.",
        "abstract": "Firework algorithm (FWA) is a new Swarm Intelligence (SI) based optimization technique, which presents a different search manner and simulates the explosion of fireworks to search the optimal solution of problem. Since it was proposed, fireworks algorithm has shown its significance and superiority in dealing with the optimization problems. However, the calculation of number of explosion spark and amplitude of firework explosion of FWA should dynamically control the exploration and exploitation of searching space with iteration. The mutation operator of FWA needs to generate the search diversity. This paper provides a kind of new method to calculate the number of explosion spark and amplitude of firework explosion. By designing a transfer function, the rank number of firework is mapped to scale of the calculation of scope and spark number of firework explosion. A parameter is used to dynamically control the exploration and exploitation of FWA with iteration going on. In addition, this paper uses a new random mutation operator to control the diversity of FWA search. The modified FWA have improved the performance of original FWA. By experiment conducted by the standard benchmark functions, the performance of improved FWA can match with that of particle swarm optimization (PSO). \u00a9 2013 Springer-Verlag Berlin Heidelberg.",
        "keywords": [
            "exploration and exploitation",
            "firework algorithm",
            "pso",
            "swarm intelligence algorithm"
        ],
        "authors": [
            {
                "name": "Jianhua Liu",
                "org": ""
            },
            {
                "name": "Shaoqiu Zheng",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            }
        ],
        "venue": "ICSI (1)",
        "year": 2013
    },
    "oekGGbC9": {
        "id": "oekGGbC9",
        "title": "Extracting discriminative information from e-mail for spam detection inspired by Immune System",
        "abstract": "Inspired from Biological Immune System, we propose a local concentration based feature extraction (LC) approach for anti-spam. A general anti-spam model is built to incorporate the LC approach with term selection methods and classifiers. In the LC model, each message is divided into areas by a sliding window. At each area, a two-dimensional feature is constructed by calculating the concentrations of spam and legitimate email. Then all the features of each area are combined together as a whole feature vector. Several experiments are conducted on four benchmark corpora, by using 10-fold cross-validation. It is shown that the LC approach can extract the effective position correlated information from messages. Compared to the prevalent Bag-of-Words approach, the LC has better performance in terms of both accuracy and F1 measure. Most significantly, the LC approach can reduce feature dimensionality greatly and has much faster speed.",
        "keywords": [
            "discriminative information extraction",
            "biological immune system",
            "spam detection",
            "local concentration",
            "unsolicited e-mail",
            "10-fold cross-validation",
            "e-mail",
            "feature extraction",
            "term selection method",
            "anti-spam model",
            "feature vector",
            "cross validation",
            "bag of words",
            "accuracy",
            "immune system",
            "construction industry",
            "sliding window"
        ],
        "authors": [
            {
                "name": "Yuanchun Zhu",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Ying Tan",
                "org": "Peking University(Peking University),Beijing,China"
            }
        ],
        "venue": "IEEE Congress on Evolutionary Computation",
        "year": 2010
    },
    "qr6yALKw": {
        "id": "qr6yALKw",
        "title": "Enhanced Fireworks Algorithm",
        "abstract": "In this paper, we present an improved version of the recently developed Fireworks Algorithm (FWA) based on several modifications. A comprehensive study on the operators of conventional FWA revealed that the algorithm works surprisingly well on benchmark functions which have their optimum at the origin of the search space. However, when being applied on shifted functions, the quality of the results of conventional FWA deteriorates severely and worsens with increasing shift values, i.e., with increasing distance between function optimum and origin of the search space. Moreover, compared to other metaheuristic optimization algorithms, FWA has high computational cost per iteration. In order to tackle these limitations, we present five major improvements of FWA: (i) a new minimal explosion amplitude check, (ii) a new operator for generating explosion sparks, (iii) a new mapping strategy for sparks which are out of the search space, (iv) a new operator for generating Gaussian sparks, and (v) a new operator for selecting the population for the next iteration. The resulting algorithm is called Enhanced Fireworks Algorithm (EFWA). Experimental evaluation on twelve benchmark functions with different shift values shows that EFWA outperforms conventional FWA in terms of convergence capabilities, while reducing the runtime significantly.",
        "keywords": [
            "metaheuristic optimization algorithms",
            "efwa",
            "gaussian spark generation",
            "search problems",
            "heuristic programming",
            "explosion spark generation",
            "search space algorithm",
            "minimal explosion amplitude check",
            "enhanced fireworks algorithm",
            "mapping strategy",
            "swarm intelligence",
            "optimization",
            "statistics",
            "benchmark testing",
            "sociology"
        ],
        "authors": [
            {
                "name": "Shaoqiu Zheng",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Andreas Janecek",
                "org": "Universitat Wien(University of Vienna,Universit\u00e4t Wien),Vienna,Austria"
            },
            {
                "name": "Ying Tan",
                "org": "Peking University(Peking University),Beijing,China"
            }
        ],
        "venue": "IEEE Congress on Evolutionary Computation",
        "year": 2013
    },
    "jpz44ZxK": {
        "id": "jpz44ZxK",
        "title": "An intelligent multi-feature statistical approach for discrimination of driving conditions of hybrid electric vehicle",
        "abstract": "As a new kind of vehicles with low fuel cost and low emission, hybrid electric vehicle (REV) has been given more and more attentions in recent years. The key technique in the HEV is adopting the optimal control strategy for the best performance. As the premise, a correct driving condition discrimination has an extremely important significance. This paper proposes an intelligent multi-feature statistical approach to discriminate the driving conditions of the HEV automatically. First of all, this approach samples the driving cycle periodically. Then it extracts multiple statistical features and tests their significance by statistical analysis. After that, it applies SVM and other machine learning methods to discriminate the driving conditions intelligently and automatically. Compared to the others, the proposed approach can compute fast and discriminate in real time during the whole HEV running. In our experiments, it reaches an accuracy of 97%. As a result, our approach can mine the valid information in the data completely and extract multiple features which have clear meanings and significance. Finally, according to the prediction experiment by a neural network and the fitting experiment by the ARMA model, it turns out that our proposed approach raises the efficiency of controlling the HEV considerably.",
        "keywords": [
            "important significance",
            "correct driving condition discrimination",
            "intelligent multi-feature statistical approach",
            "hybrid electric vehicle",
            "multiple statistical feature",
            "approach sample",
            "driving cycle",
            "statistical analysis",
            "whole hev",
            "driving condition",
            "testing",
            "svm",
            "neural network",
            "feature extraction",
            "real time",
            "machine learning",
            "support vector machines",
            "optimal control",
            "histograms",
            "learning artificial intelligence",
            "intelligent control",
            "arma model",
            "data mining"
        ],
        "authors": [
            {
                "name": "Xi Huang",
                "org": "Key Laboratory of Machine Perception and Intelligence and Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, MOE, Beijing, P. R. China"
            },
            {
                "name": "Ying Tan",
                "org": "Key Laboratory of Machine Perception and Intelligence, MOE and Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, MOE, Beijing, P. R. Ch ..."
            },
            {
                "name": "Xingui He",
                "org": "Key Laboratory of Machine Perception and Intelligence, MOE and Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, MOE, Beijing, P. R. Ch ..."
            }
        ],
        "venue": "IJCNN",
        "year": 2009
    },
    "7w5qJuz4": {
        "id": "7w5qJuz4",
        "title": "KNOB Particle Swarm Optimizer",
        "abstract": "\n It is not trivial to tune the swarm behavior just by parameter setting because of the randomness, complexity and dynamic involved\n in particle swarm optimizer (PSO). Hundreds of variants in the literature of last decade, brought various mechanism or ideas,\n sometimes also from outside of the traditional metaheuristics field, to tune the swarm behavior. While, in the same time,\n additional parameters have to be afforded. This paper proposes a new mechanism, named KNOB, to directly tune the swarm behavior\n through parameter setting of PSO. KNOB is defined as the first principal component of the statistical probability sequence\n of exploration and exploitation allocation along the search process. The using of the KNOB to tune PSO by parameter setting\n is realized through a statistical mapping, between the parameter set and the KNOB, learned by a radial basis function neural\n network (RBFNN) simulation model. In this way, KNOB provides an easy way to tune PSO directly by its parameter setting. A\n simple application of KNOB to promote is presented to verify the mechanism of KNOB.\n \n ",
        "keywords": [
            "search strategy",
            "parameter setting",
            "new mechanism",
            "swarm behavior",
            "additional parameter",
            "exploitation",
            "statistical mapping",
            "statistical probability sequence",
            "exploration",
            "parameter set",
            "knob particle swarm optimizer",
            "knob.",
            "pso knob",
            "various mechanism",
            "particle swarm optimizer",
            "simulation model",
            "principal component"
        ],
        "authors": [
            {
                "name": "Junqi Zhang",
                "org": "Tongji University Key Laboratory of Embedded System and Service Computing, Ministry of Education, Department of Computer Science and Technology Shanghai 200092 China"
            },
            {
                "name": "Kun Liu",
                "org": "Peking University Key Laboratory of Machine Perception, Ministry of Education, Department of Machine Intelligence, School of Electronics Engineering and Computer Science Beijing 100871 China"
            },
            {
                "name": "Ying Tan",
                "org": "Peking University Key Laboratory of Machine Perception, Ministry of Education, Department of Machine Intelligence, School of Electronics Engineering and Computer Science Beijing 100871 China"
            }
        ],
        "venue": "international conference on swarm intelligence",
        "year": 2010
    },
    "gqQX0199": {
        "id": "gqQX0199",
        "title": "An empirical study on influence of approximation approaches on enhancing fireworks algorithm",
        "abstract": "This paper presents an empirical study on the influence of approximation approaches on accelerating the fireworks algorithm search by elite strategy. In this study, we use three sampling data methods to approximate fitness landscape, i.e. the best fitness sampling method, the sampling distance near the best fitness individual sampling method and the random sampling method. For each approximation methods, we conduct a series of combinative evaluations with the different sampling method and sampling number for accelerating fireworks algorithm. The experimental evaluations on benchmark functions show that this elite strategy can enhance the fireworks algorithm search capability effectively. We also analyze and discuss the related issues on the influence of approximation model, sampling method, and sampling number on the fireworks algorithm acceleration performance.",
        "keywords": [
            "fireworks algorithm searching",
            "acceleration",
            "random sampling method",
            "evolutionary computation",
            "approximation theory",
            "sampling data method",
            "approximation",
            "elite strategy",
            "best fitness sampling method",
            "fitness landscape",
            "search problems",
            "fireworks algorithm acceleration",
            "fireworks algorithm",
            "sampling methods",
            "fitness landscape approximation",
            "combinative evaluation",
            "benchmark testing",
            "empirical study",
            "approximation algorithms",
            "least squares approximation"
        ],
        "authors": [
            {
                "name": "Yan Pei",
                "org": ""
            },
            {
                "name": "Shaoqiu Zheng",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Hideyuki Takagi",
                "org": ""
            }
        ],
        "venue": "SMC",
        "year": 2012
    },
    "Kg73HnWg": {
        "id": "Kg73HnWg",
        "title": "Particle swarm optimization based learning algorithm for process neural networks",
        "abstract": "This paper proposes a new learning algorithm for process neural networks (PNNs) based on particle swarm optimization (PSO), called PSO-LM. After the orthogonal basis function expansion to the input functions and the weight functions of the PNN, the structure parameters and other parameters in the PNN will be formed as a particle, and globally optimized by PSO. This algorithm does not need any gradient calculations or the manual control of the network's structure. The global learning capability and the convergence capability of the PNN can be guaranteed by the capabilities of PSO, so the PSO-LM can better develop and improve the approximation capability of the PNN. According to two practical prediction applications, PSO-LM can outperform the existing basis function expansion based learning algorithm (BFE-LM) for PNNs, and the classic back propagation neural networks (BPNNs) on predictive accuracy.",
        "keywords": [
            "Basis function expansion",
            "Learning algorithm",
            "Particle swarm optimization",
            "Process neural networks"
        ],
        "authors": [
            {
                "name": "Kun Liu",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Ying Tan",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Xingui He",
                "org": "Peking University(Peking University),Beijing,China"
            }
        ],
        "venue": "Beijing Daxue Xuebao (Ziran Kexue Ban)/Acta Scientiarum Naturalium Universitatis Pekinensis",
        "year": 2011
    },
    "KBspsXf5": {
        "id": "KBspsXf5",
        "title": "Fireworks Algorithm for Optimization",
        "abstract": "\n Inspired by observing fireworks explosion, a novel swarm intelligence algorithm, called Fireworks Algorithm (FA), is proposed\n for global optimization of complex functions. In the proposed FA, two types of explosion (search) processes are employed,\n and the mechanisms for keeping diversity of sparks are also well designed. In order to demonstrate the validation of the FA,\n a number of experiments were conducted on nine benchmark test functions to compare the FA with two variants of particle swarm\n optimization (PSO) algorithms, namely Standard PSO and Clonal PSO. It turns out from the results that the proposed FA clearly\n outperforms the two variants of the PSOs in both convergence speed and global solution accuracy.\n \n ",
        "keywords": [
            "novel swarm intelligence algorithm",
            "benchmark test function",
            "clonal pso",
            "natural computing",
            "fireworks algorithm",
            "particle swarm optimization",
            "standard pso",
            "global solution accuracy",
            "swarm intelligence",
            "global optimization",
            "proposed fa",
            "fireworks explosion",
            "function optimization."
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": "Peking University Key Laboratory of Machine Perception (MOE), Peking University Department of Machine Intelligence, School of Electronics Engineering and Computer Science Beijing 100871 China"
            },
            {
                "name": "Yuanchun Zhu",
                "org": "Peking University Key Laboratory of Machine Perception (MOE), Peking University Department of Machine Intelligence, School of Electronics Engineering and Computer Science Beijing 100871 China"
            }
        ],
        "venue": "international conference on swarm intelligence",
        "year": 2010
    },
    "56bloBlw": {
        "id": "56bloBlw",
        "title": "A classifier based on minimum circum circle",
        "abstract": "A new linear classifier based on minimum circum circle (CMCC) is proposed in this paper. It first calculates the minimum circum circle of samples for each class. Then the distributions of the samples can be described by these circles. The linear separating hyperplane will intersect the connecting line of the centers of circles. Consequently, the perpendicular to the connecting line of each two centers is defined as the classifier of these two classes. Moreover, some improved classifiers are proposed when the separating hyperplane is not perpendicular to the connecting line or when there are outliers in the samples. The combined classifier based on subclasses is also discussed. In the experiments, the CMCC and its improved algorithms are compared with some other classifiers such as support vector machine, linear discriminant analysis, etc. The experimental results show that the CMCC gives a relatively good performance on both classification accuracy and time cost.",
        "keywords": [
            "support vector machine",
            "improved classifier",
            "combined classifier",
            "good performance",
            "classification accuracy",
            "improved algorithm",
            "new linear classifier",
            "linear discriminant analysis",
            "minimum circum circle",
            "classifier",
            "machine learning"
        ],
        "authors": [
            {
                "name": "Xi Huang",
                "org": "Key Laboratory of Machine Perception and Intelligence, Peking University, Beijing, P.R. China,Ministry of Education, Department of Machine Intelligence, School of Electronics Engineering and Compu ..."
            },
            {
                "name": "Ying Tan",
                "org": "Key Laboratory of Machine Perception and Intelligence, Peking University, Beijing, P.R. China,Ministry of Education, Department of Machine Intelligence, School of Electronics Engineering and Compu ..."
            },
            {
                "name": "Xingui He",
                "org": "Key Laboratory of Machine Perception and Intelligence, Peking University, Beijing, P.R. China,Ministry of Education, Department of Machine Intelligence, School of Electronics Engineering and Compu ..."
            }
        ],
        "venue": "ICSI",
        "year": 2012
    },
    "iooK00vF": {
        "id": "iooK00vF",
        "title": "Random black hole particle swarm optimization and its application",
        "abstract": "This paper introduces a novel particle swarm optimization algorithm based on the concept of black holes in physics, called random black hole particle swarm optimization (RBH-PSO) for the first time. In each dimension of a particle, we randomly generate a black hole located nearest to the best particle of the swarm in current generation and then randomly pull particles of the swarm into the black hole with a probability p. By this mechanism of random black hole, we can give all the particles another interesting direction to converge as well as another chance to fly out of local minima when a premature convergence happens. Several experiments on fifteen benchmark test functions are conducted to demonstrate that the proposed RBH-PSO algorithm is able to speedup the evolution process distinctly and improve the performance of global optimizer greatly. Finally, an actual application of the proposed algorithm to spam detection is conducted then compared to other three current methods. \u00a9 2008 IEEE.",
        "keywords": [
            "black hole",
            "pso",
            "spam detection",
            "swarm intelligence",
            "global optimization",
            "particle swarm optimization",
            "benchmark testing",
            "convergence",
            "intelligent networks",
            "helium",
            "neural networks",
            "premature convergence",
            "support vector machines",
            "local minima",
            "algorithm design and analysis",
            "optimization",
            "physics education",
            "black holes",
            "signal processing",
            "machine intelligence"
        ],
        "authors": [
            {
                "name": "Junqi Zhang",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Kun Liu",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Ying Tan",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Xingui He",
                "org": "Peking University(Peking University),Beijing,China"
            }
        ],
        "venue": "2008 IEEE International Conference Neural Networks and Signal Processing, ICNNSP",
        "year": 2008
    },
    "bureTr1K": {
        "id": "bureTr1K",
        "title": "Nonlinear blind source separation using higher order statistics and a genetic algorithm",
        "abstract": "This paper presents a novel method for blindly separating unobservable independent source signals from their nonlinear mixtures. The demixing system is modeled using a parameterized neural network whose parameters can be determined under the criterion of independence of its outputs. Two cost functions based on higher order statistics are established to measure the statistical dependence of the outputs of the demixing system. The proposed method utilizes a genetic algorithm (GA) to minimize the highly nonlinear and nonconvex cost functions. The GA-based global optimization technique is able to obtain superior separation solutions to the nonlinear blind separation problem from any random initial values. Compared to conventional gradient-based approaches, the GA-based approach for blind source separation is characterized by high accuracy, robustness, and convergence rate. In particular, it is very suitable for the case of limited available data. Simulation results are discussed to demonstrate that the proposed GA-based approach is capable of separating independent sources from their nonlinear mixtures generated by a parametric separation model",
        "keywords": [
            "statistical independence",
            "nonlinear mix- ture",
            "demixing system",
            "statistical independence.",
            "nonlinear mixture",
            "feedforward neural nets",
            "convergence",
            "higher order statistics",
            "index terms\u2014blind source separation",
            "blind source separation",
            "genetic algorithms",
            "feedforward neural networks",
            "signal detection",
            "feedforward neural net- works",
            "signal processing",
            "speech processing",
            "biosensors",
            "convergence rate",
            "neural network",
            "cost function",
            "neural networks",
            "indexing terms",
            "genetic algorithm"
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Jun Wang",
                "org": ""
            }
        ],
        "venue": "IEEE Trans. Evolutionary Computation",
        "year": 2001
    },
    "T3IRzR2u": {
        "id": "T3IRzR2u",
        "title": "Scouting strategy for biasing fireworks algorithm search to promising directions.",
        "abstract": "We propose a scouting strategy to find better searching directions in fireworks algorithm (FWA) to enhance its exploitation capability. It generates spark individuals from a firework individual one by one by checking if the generated spark climbs up to a better direction, and this process continues until spark individual climbing down is generated, while canonical FWA generates spark individuals around a firework individual at once. We can know potential search directions from the number of consciously climbing up sparks. Besides this strategy, we use a filtering strategy for a random selection of FWA, where worse sparks are eliminated when their fitness is worse than their parents, i.e. fireworks, and become unable to survive in the next generation. We combined these strategies with the enhanced FWA (EFWA) and evaluated using 28 CEC2013 benchmark functions. Experimental results confirm that the proposed strategies are effective and show better performance in terms of convergence speed and accuracy. Finally, we analyze their applicability and provide some open topics.\n\n",
        "keywords": "",
        "authors": [
            {
                "name": "Jun Yu",
                "org": "Kyushu University, Fukuoka, Japan"
            },
            {
                "name": "Ying Tan",
                "org": "Peking University, Beijing, China"
            },
            {
                "name": "Hideyuki Takagi",
                "org": "Kyushu University, Fukuoka, Japan"
            }
        ],
        "venue": "GECCO (Companion)",
        "year": 2018
    },
    "KOxUrmse": {
        "id": "KOxUrmse",
        "title": "Feeding the fish - weight update strategies for the fish school search algorithm",
        "abstract": "Choosing optimal parameter settings and update strategies is a key issue for almost all population based optimization algorithms based on swarm intelligence. For state-of-the-art optimization algorithms the optimal parameter settings and update strategies for different problem sizes are well known. In this paper we investigate and compare different newly developed weight update strategies for the recently developed Fish School Search (FSS) algorithm. For this algorithm the optimal update strategies have not been investigated so far. We introduce a new dilation multiplier as well as different weight update steps where fish in poor regions loose weight more quickly than fish in regions with a lot of food. Moreover, we show how a simple non-linear decrease of the individual and volitive step parameters is able to significantly speed up the convergence of FSS.",
        "keywords": [
            "state-of-the-art optimization",
            "different weight update step",
            "optimization algorithm",
            "loose weight",
            "optimal update strategy",
            "different problem size",
            "fish school search algorithm",
            "update strategy",
            "weight update strategy",
            "volitive step parameter",
            "optimal parameter setting"
        ],
        "authors": [
            {
                "name": "Andreas Janecek",
                "org": "Key Laboratory of Machine Perception (MOE), Peking University, Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, Beijing, China"
            },
            {
                "name": "Ying Tan",
                "org": "Key Laboratory of Machine Perception (MOE), Peking University, Department of Machine Intelligence, School of Electronics Engineering and Computer Science, Peking University, Beijing, China"
            }
        ],
        "venue": "ICSI",
        "year": 2011
    },
    "4HcsbOzA": {
        "id": "4HcsbOzA",
        "title": "Kinematic learning in humans and robots",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shouhan zhou",
                "org": ""
            },
            {
                "name": "denny oetomo",
                "org": ""
            },
            {
                "name": "ying tan",
                "org": ""
            },
            {
                "name": "c t freeman",
                "org": ""
            },
            {
                "name": "etienne burdet",
                "org": ""
            },
            {
                "name": "iven mareels",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "7UaIizZ4": {
        "id": "7UaIizZ4",
        "title": "On the choice of dither in extremum seeking systems: A case study",
        "abstract": "We discuss how the choice of dither (excitation signal) affects the performance of extremum seeking using a benchmark situation: a static scalar map; and a simple scalar extremum seeking scheme. Our comparisons are based on the performance of the system with different dithers in terms of three performance indicators: the speed of convergence, domain of attraction and accuracy (i.e.\u00a0the ultimate bound on trajectories). Our analysis explicitly shows how the dither shape affects each of these performance indicators. Our study suggests that the practitioners using extremum seeking control should consider the dither shape as an important design parameter. Computer simulations support our theoretical findings.",
        "keywords": [
            "Extremum seeking control",
            "Dither choice",
            "Performance indicators"
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Dragan Ne\u0161i\u0107",
                "org": "The Department of Electrical & Electronics Engineering, The University of Melbourne, Melbourne, VIC 3010, Australia"
            },
            {
                "name": "Iven Mareels",
                "org": "The Department of Electrical & Electronics Engineering, The University of Melbourne, Melbourne, VIC 3010, Australia"
            }
        ],
        "venue": "Automatica",
        "year": 2008
    },
    "lsu05IF0": {
        "id": "lsu05IF0",
        "title": "Dual-loop iterative optimal control for the finite horizon LQR problem with unknown dynamics.",
        "abstract": "Achieving optimal performance over a finite-time horizon has gained a lot of attention in many engineering applications. Among them, the Finite Horizon Linear Quadratic Regulator (FHLQR) formulation for continuous-time linear time-varying systems has been well studied, with an optimal solution characterised by the Differential Riccati Equation (DRE). The solution of the DRE requires that the exact system dynamics are known. However, this assumption may not always hold, as the plant model might not be completely known or may change over time due to wear and tear. This paper proposes a dual-loop iterative algorithm to find the optimal solutions of the FHLQR formulation for continuous-time LTV systems. The inner loop utilises input trajectories based on an estimate of the optimal control gain with the addition of some excitation noise, and produces measured state trajectories. The outer loop improves the estimate of the optimal control gain utilising these measured state trajectories. It is shown in this work that with appropriate selection of the discretisation parameter  T  and the set of excitation signals, the proposed dual-loop iterative algorithm can converge to an arbitrarily small neighbourhood of the optimal solution. A simulation example demonstrates the effectiveness of the proposed method.",
        "keywords": [
            "Finite Horizon linear quadratic regulator",
            "Continuous-time",
            "Dual-loop iterative algorithm"
        ],
        "authors": [
            {
                "name": "Justin Fong",
                "org": "Melbourne School of Engineering, The University of Melbourne, Parkville, Victoria, 3031, Australia"
            },
            {
                "name": "Ying Tan",
                "org": "Melbourne School of Engineering, The University of Melbourne, Parkville, Victoria, 3031, Australia"
            },
            {
                "name": "Vincent Crocher",
                "org": "Melbourne School of Engineering, The University of Melbourne, Parkville, Victoria, 3031, Australia"
            },
            {
                "name": "Denny Oetomo",
                "org": "Melbourne School of Engineering, The University of Melbourne, Parkville, Victoria, 3031, Australia"
            },
            {
                "name": "Iven Mareels",
                "org": "Melbourne School of Engineering, The University of Melbourne, Parkville, Victoria, 3031, Australia"
            }
        ],
        "venue": "Systems & Control Letters",
        "year": 2018
    },
    "HVchdjwN": {
        "id": "HVchdjwN",
        "title": "Upper Limb Deweighting Using Underactuated End-Effector-Based Backdrivable Manipulanda.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Vincent Crocher",
                "org": "University of Melbourne"
            },
            {
                "name": "Justin Fong",
                "org": "University of Melbourne"
            },
            {
                "name": "Teun Jan Bosch",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": "University of Melbourne"
            },
            {
                "name": "Iven Mareels",
                "org": "University of Melbourne"
            },
            {
                "name": "Denny Oetomo",
                "org": "University of Melbourne"
            }
        ],
        "venue": "IEEE Robotics and Automation Letters",
        "year": 2018
    },
    "dZX9rJtE": {
        "id": "dZX9rJtE",
        "title": "On non-local stability properties of extremum seeking control",
        "abstract": "In this paper, we consider several extremum seeking schemes and show under appropriate conditions that these schemes achieve extremum seeking from an arbitrarily large domain of initial conditions if the parameters in the controller are appropriately adjusted. This non-local stability result is proved by showing semi-global practical stability of the closed-loop system with respect to the design parameters. We show that reducing the size of the parameters typically slows down the convergence rate of the extremum seeking controllers and enlarges the domain of the attraction. Our results provide guidelines on how to tune the controller parameters in order to achieve extremum seeking. Simulation examples illustrate our results.",
        "keywords": [
            "Extremum seeking control",
            "Semi-global practical stability",
            "Convergence speed",
            "Domain of the attraction"
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": "The Department of Electrical and Electronics Engineering, The University of Melbourne, Melbourne, VIC 3010, Australia"
            },
            {
                "name": "Dragan Ne\u0161i\u0107",
                "org": "The Department of Electrical and Electronics Engineering, The University of Melbourne, Melbourne, VIC 3010, Australia"
            },
            {
                "name": "Iven Mareels",
                "org": "The Department of Electrical and Electronics Engineering, The University of Melbourne, Melbourne, VIC 3010, Australia"
            }
        ],
        "venue": "Automatica",
        "year": 2006
    },
    "w1dyrLk5": {
        "id": "w1dyrLk5",
        "title": "Robustness of Nonlinear Vibrational Control Systems based on Sampling Lyapunov Method.",
        "abstract": "Vibrational control algorithms have been shown their potential in achieving stability and improving the performance of engineering systems by injecting high-frequency dither signals. This paper presents the robustness analysis of nonlinear vibrational control systems while disturbances exist. The linearization matrix of the averaged system is assumed to be Hurwitz such that the nonlinear vibrational control system is vibrationally stabilizable without disturbances. In the presence of disturbances, the domain of attraction can be estimated by constructing a quadratic Lyapunov function, which provides an upper bound of disturbances that the system can handle. For all initial points from the domain of attraction, all disturbances constrained within the estimated bound, a Lyapunov-based sampling method is applied to show that the solutions converge to an ultimate bound, which is a function of the bound of disturbances. That indicates the stabilized vibrational control systems are robust to a class of additive and bounded disturbances. As an illustrative example, an inverted pendulum stabilized by the vibrational control algorithm is shown to have the ability to track a vertically moving target without a feedback, in which moving speed is regarded as a disturbance. Numerical results support the theoretic findings.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaoxiao Cheng",
                "org": "University of Melbourne, Melbourne School of Engineering, VIC, 3010, Australia"
            },
            {
                "name": "Ying Tan",
                "org": "University of Melbourne, Melbourne School of Engineering, VIC, 3010, Australia"
            },
            {
                "name": "Iven Mareels",
                "org": "University of Melbourne, Melbourne School of Engineering, VIC, 3010, Australia"
            }
        ],
        "venue": "ACC",
        "year": 2018
    },
    "qZV6xZLT": {
        "id": "qZV6xZLT",
        "title": "On-line Synergy Identification for Personalized Active Arm Prosthesis: a Feasibility Study.",
        "abstract": "The number of degrees of freedom in prosthetic devices today is greater than the number of available electromyographic signals from the residual limb. This potentially causes complex and unintuitive interfaces, which in turn have been cited as a leading cause of prosthetic device abandonment. Synergistic arm prosthesis control allows for an intuitive way to provide additional information to command the motion of the prosthesis by coordinating the motion relationship between the prosthesis and the residual limb. There is a challenge in identifying effective synergies, especially as the motion of an amputee generally differs from the synergy of the typical ablebodied subjects, from person to person, and along the time of prosthesis usage. In this paper, a framework for on-line data driven optimization is proposed to identify the optimal synergy setting for an individual performing a specific task, formulated as an optimization problem based on human motor control. This is done through the characterization of the task by a cost function and the parametrization of the synergy. The proposed framework is able to characterize and identify the synergy of the task of reaching for a given location, with a healthy subject in the loop. The framework is used to drive the motion of an elbow prosthesis using its synergy with the residual shoulder movement of the human subject as input. A simple parametrization for the synergy is used in this paper to demonstrate the idea of the proposed framework. Human-in-the-loop simulation results are presented, showing the feasibility of data driven optimization for on-line synergy identification in the context of an arm prosthesis.",
        "keywords": "",
        "authors": [
            {
                "name": "Ricardo Garcia-Rosas",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": "University of Melbourne, School of Electrical, Mechanical and Infrastructure Engineering, VIC, 3010, Australia"
            },
            {
                "name": "Denny Oetomo",
                "org": "University of Melbourne, School of Electrical, Mechanical and Infrastructure Engineering, VIC, 3010, Australia"
            },
            {
                "name": "Chris Manzie",
                "org": "University of Melbourne, School of Electrical, Mechanical and Infrastructure Engineering, VIC, 3010, Australia"
            }
        ],
        "venue": "ACC",
        "year": 2018
    },
    "9KBenrIU": {
        "id": "9KBenrIU",
        "title": "Effects of varying the rest period on the onset angle of lumbar flexion-relaxation in simulated sheep shearing: a preliminary study.",
        "abstract": "Wool harvesting remains an important industry in Australia, but its workers suffer from extreme rates of injury, in particular, the lower back injuries. Reducing injuries in sheep shearing could be as simple as extending shearer rest periods between sheep, but the effect of this has not previously been studied. The lumbar flexion-relaxation phenomenon is present in sheep shearing and the onset angle of this phenomenon can provide insight into lower back injury risk. The increase in the onset angle of lumbar flexion-relaxation over several work-rest periods for a simulated sheep shearing task is studied. The rate of increase in the onset angle of lumbar flexion-relaxation was higher when shorter breaks were taken for all participants at least unilaterally, indicating that longer rest breaks could reduce back injury risk. Due to the constraints of the sheep shearing occupation, this type of intervention is better suited to learner and novice shearers. Assistive robotic devices would be more suited to reduce injuries in expert shearers, and some insight is provided for the application of these within sheep shearing. Further study of this phenomenon in sheep shearing could provide additional insight to developing an assistive device that could reduce injury.",
        "keywords": "",
        "authors": [
            {
                "name": "Mark Robinson",
                "org": "Department of Mechanical Engineering, University of Melbourne, Parkville, 3010, Australia"
            },
            {
                "name": "Raphael Mayer",
                "org": "Department of Mechanical Engineering, University of Melbourne, Parkville, 3010, Australia"
            },
            {
                "name": "Ying Tan",
                "org": "Department of Electrical and Electronic Engineering, University of Melbourne, Parkville, 3010, Australia"
            },
            {
                "name": "Denny Oetomo",
                "org": "Department of Mechanical Engineering, University of Melbourne, Parkville, 3010, Australia"
            },
            {
                "name": "Chris Manzie",
                "org": "Department of Electrical and Electronic Engineering, University of Melbourne, Parkville, 3010, Australia"
            }
        ],
        "venue": "IEEE ... International Conference on Rehabilitation Robotics : [proceedings]",
        "year": 2019
    },
    "O4qPe1S6": {
        "id": "O4qPe1S6",
        "title": "Trajectory-based proofs for sampled-data extremum seeking control.",
        "abstract": "",
        "keywords": [
            "sampled data systems",
            "lyapunov function",
            "convergence",
            "nonlinear systems",
            "steady state",
            "asymptotic stability",
            "robustness",
            "optimization",
            "optimal control",
            "nonlinear system"
        ],
        "authors": [
            {
                "name": "Sei Zhen Khong",
                "org": ""
            },
            {
                "name": "Dragan Nesic",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Chris Manzie",
                "org": ""
            }
        ],
        "venue": "ACC",
        "year": 2013
    },
    "cTL9hbG2": {
        "id": "cTL9hbG2",
        "title": "Unified frameworks for sampled-data extremum seeking control: Global optimisation and multi-unit systems",
        "abstract": "Two frameworks are proposed for extremum seeking of general nonlinear plants based on a sampled-data control law, within which a broad class of nonlinear programming methods is accommodated. It is established that under some generic assumptions, semi-global practical convergence to a global extremum can be achieved. In the case where the extremum seeking algorithm satisfies a stronger asymptotic stability property, the converging sequence is also shown to be stable using a trajectory-based proof, as opposed to a Lyapunov-function-type approach. The former is more straightforward and insightful. This allows for more general optimisation algorithms than considered in existing literature, such as those which do not admit a state-update realisation and/or Lyapunov functions. Lying at the heart of the analysis throughout is robustness of the optimisation algorithms to additive perturbations of the objective function. Multi-unit extremum seeking is also investigated with the objective of accelerating the speed of convergence.",
        "keywords": [
            "Extremum seeking",
            "Sampled-data control",
            "Nonconvex global optimisation",
            "Robustness",
            "Multi-unit systems"
        ],
        "authors": [
            {
                "name": "Sei Zhen Khong",
                "org": ""
            },
            {
                "name": "Dragan Ne\u0161I\u0107",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Chris Manzie",
                "org": ""
            }
        ],
        "venue": "Automatica",
        "year": 2013
    },
    "0J4Zb5Mg": {
        "id": "0J4Zb5Mg",
        "title": "Unified iterative learning control schemes for nonlinear dynamic systems with nonlinear input uncertainties",
        "abstract": "In many ILC algorithms, nonlinear input uncertainties such as saturation, dead-zone and hysteresis, which do exist due to practical implementations, are always ignored. Although various ILC algorithms have been proposed to compensate various nonlinear input uncertainties, a systematic design framework is still missing. This note presents a unified design framework to deal with very general nonlinear input uncertainties. The concept of a dual-loop ILC is introduced. One ILC loop (ILC Loop 1) is designed for the nominal model without nonlinear input uncertainties. The other ILC loop (ILC Loop 2) uses some iterative algorithms to handle nonlinear input uncertainties. Two ILC loops can be designed independently and are connected by a proper time-scale separation. Our first result shows that by using time-scale separation, the overall system semi-globally practically converges to the desired trajectory if ILC Loop 2 uniformly converges. Furthermore, if ILC Loop 2 converges ''almost'' monotonically, ILC Loop 1 and ILC Loop 2 can update simultaneously to achieve uniform convergence of the overall system.",
        "keywords": [
            "Dual-loop iterative learning control",
            "Nonlinear input uncertainties",
            "Inter-connections"
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": "Department of Electrical & Electronic Engineering, University of Melbourne, Parkville, VIC 3010, Australia"
            },
            {
                "name": "Hao-Hui Dai",
                "org": "Department of Mathematics, East China Normal University, Shanghai 200241, PR China"
            },
            {
                "name": "Deqing Huang",
                "org": "Department of Electrical and Computer Engineering, National University of Singapore, Singapore 117576, Singapore"
            },
            {
                "name": "Jian-Xin Xu",
                "org": "Department of Electrical and Computer Engineering, National University of Singapore, Singapore 117576, Singapore"
            }
        ],
        "venue": "Automatica",
        "year": 2012
    },
    "g1olm934": {
        "id": "g1olm934",
        "title": "Robustness analysis of leader-follower consensus.",
        "abstract": "In this paper, robustness properties of the leader-follower consensus are considered. For simplicity of presentation, the\n attention is focused on a group of continuous-time first-order dynamic agents with a time-invariant communication topology\n in the presence of communication errors. In order to evaluate the robustness of leader-follower consensus, two robustness\n measures are proposed: the L\n 2 gain of the error vector to the state of the network and the worst case L\n 2 gain at a node. Although the L\n 2 gain of the error vector to the state of the network is widely used in robust control design and analysis, the worst case\n L\n 2 gain at a node is less conservative with respect to the number of nodes in the network. It is thus suggested that the worst\n case L\n 2 gain at a node is used when the robustness of consensus is considered. Theoretical analysis and simulation results show that\n these two measures are sensitive to the communication topology. In general, the \u201coptimal\u201d communication topology that can\n achieve most robust performance with respect to either of the proposed robustness measures is difficult to characterize and/or\n obtain. When the in-degree of each follower is one, it is shown that both measures reach a minimum when the leader can communicate\n to each node in the network.",
        "keywords": [
            "communication errors",
            "robustness.",
            "robustness",
            "leader-follower consensus",
            "vectors",
            "lead",
            "network topology",
            "gain",
            "aerospace engineering",
            "aerodynamics",
            "robust control",
            "topology",
            "circuit topology"
        ],
        "authors": [
            {
                "name": "Jinzhi Wang",
                "org": "Peking University State Key Laboratory for Turbulence and Complex System and Department of Mechanics and Aerospace Engineering, College of Engineering Beijing 100871 China"
            },
            {
                "name": "Ying Tan",
                "org": "University of Melbourne Department of Electrical and Electronic Engineering Melbourne VIC. 3010 Australia"
            },
            {
                "name": "Iven Mareels",
                "org": "University of Melbourne Department of Electrical and Electronic Engineering Melbourne VIC. 3010 Australia"
            }
        ],
        "venue": "J. Systems Science & Complexity",
        "year": 2009
    },
    "sn6yrTfa": {
        "id": "sn6yrTfa",
        "title": "Extremum Seeking Methods for Online Automotive Calibration",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "chris manzie",
                "org": "university of melbourne"
            },
            {
                "name": "william h moase",
                "org": "university of melbourne"
            },
            {
                "name": "rohan c shekhar",
                "org": "university of melbourne"
            },
            {
                "name": "alireza mohammadi",
                "org": "university of melbourne"
            },
            {
                "name": "dragan nesic",
                "org": "university of melbourne"
            },
            {
                "name": "ying tan",
                "org": "university of melbourne"
            }
        ],
        "venue": "",
        "year": 2014
    },
    "JaF8LJSz": {
        "id": "JaF8LJSz",
        "title": "Extremum seeking of dynamical systems via gradient descent and stochastic approximation methods",
        "abstract": "This paper examines the use of gradient based methods for extremum seeking control of possibly infinite-dimensional dynamic nonlinear systems with general attractors within a periodic sampled-data framework. First, discrete-time gradient descent method is considered and semi-global practical asymptotic stability with respect to an ultimate bound is shown. Next, under the more complicated setting where the sampled measurements of the plant's output are corrupted by an additive noise, three basic stochastic approximation methods are analysed; namely finite-difference, random directions, and simultaneous perturbation. Semi-global convergence to an optimum with probability one is established. A tuning parameter within the sampled-data framework is the period of the synchronised sampler and hold device, which is also the waiting time during which the system dynamics settle to within a controllable neighbourhood of the steady-state input-output behaviour.",
        "keywords": [
            "Extremum seeking",
            "Infinite-dimensional nonlinear systems",
            "Sampled-data control",
            "Gradient descent method",
            "Stochastic approximation methods"
        ],
        "authors": [
            {
                "name": "Sei Zhen Khong",
                "org": "Department of Automatic Control, Lund University, SE221 00 Lund, Sweden"
            },
            {
                "name": "Ying Tan",
                "org": "Department of Electrical and Electronic Engineering, The University of Melbourne, Parkville, VIC 3010, Australia"
            },
            {
                "name": "Chris Manzie",
                "org": "Department of Mechanical Engineering, The University of Melbourne, Parkville, VIC 3010, Australia"
            },
            {
                "name": "Dragan Nesic",
                "org": "Department of Electrical and Electronic Engineering, The University of Melbourne, Parkville, VIC 3010, Australia"
            }
        ],
        "venue": "Automatica",
        "year": 2015
    },
    "YUX6y8Pz": {
        "id": "YUX6y8Pz",
        "title": "Effects of robotic exoskeleton dynamics on joint recruitment in a neurorehabilitation context",
        "abstract": "",
        "keywords": [
            "sensors",
            "read only memory",
            "robots",
            "exoskeletons",
            "measurement"
        ],
        "authors": [
            {
                "name": "justin fong",
                "org": "melbourne school of engineering university of melbourne"
            },
            {
                "name": "vincent crocher",
                "org": "melbourne school of engineering university of melbourne"
            },
            {
                "name": "denny oetomo",
                "org": "melbourne school of engineering university of melbourne"
            },
            {
                "name": "ying tan",
                "org": "melbourne school of engineering university of melbourne"
            },
            {
                "name": "iven mareels",
                "org": "melbourne school of engineering university of melbourne"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "LPWv8u0y": {
        "id": "LPWv8u0y",
        "title": "Multi-agent gradient climbing via extremum seeking control",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "sei zhen khong",
                "org": ""
            },
            {
                "name": "chris manzie",
                "org": ""
            },
            {
                "name": "ying tan",
                "org": ""
            },
            {
                "name": "dragan nesic",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "TpoitQBF": {
        "id": "TpoitQBF",
        "title": "Modelling of the Point to Point Learning in Human Motor System",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "s h zhou",
                "org": ""
            },
            {
                "name": "denny oetomo",
                "org": ""
            },
            {
                "name": "ying tan",
                "org": ""
            },
            {
                "name": "c t freeman",
                "org": ""
            },
            {
                "name": "etienne burdet",
                "org": ""
            },
            {
                "name": "iven mareels",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "wgwyLyUE": {
        "id": "wgwyLyUE",
        "title": "Human Motor Learning through Iterative Model Reference Adaptive Control",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shouhan zhou",
                "org": ""
            },
            {
                "name": "denny oetomo",
                "org": ""
            },
            {
                "name": "ying tan",
                "org": ""
            },
            {
                "name": "etienne burdet",
                "org": ""
            },
            {
                "name": "iven mareels",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2011
    },
    "ROrlm9YV": {
        "id": "ROrlm9YV",
        "title": "Technical communique: On the choice of dither in extremum seeking systems: A case study",
        "abstract": "We discuss how the choice of dither (excitation signal) affects the performance of extremum seeking using a benchmark situation: a static scalar map; and a simple scalar extremum seeking scheme. Our comparisons are based on the performance of the system with different dithers in terms of three performance indicators: the speed of convergence, domain of attraction and accuracy (i.e. the ultimate bound on trajectories). Our analysis explicitly shows how the dither shape affects each of these performance indicators. Our study suggests that the practitioners using extremum seeking control should consider the dither shape as an important design parameter. Computer simulations support our theoretical findings.",
        "keywords": [
            "different dither",
            "technical communique",
            "important design parameter",
            "benchmark situation",
            "theoretical finding",
            "excitation signal",
            "dither shape",
            "static scalar map",
            "case study",
            "simple scalar extremum",
            "computer simulation",
            "performance indicator",
            "performance indicators"
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": "The Department of Electrical & Electronics Engineering, The University of Melbourne, Melbourne, VIC 3010, Australia"
            },
            {
                "name": "Dragan Ne\u0161i\u0107",
                "org": "The Department of Electrical & Electronics Engineering, The University of Melbourne, Melbourne, VIC 3010, Australia"
            },
            {
                "name": "Iven Mareels",
                "org": "The Department of Electrical & Electronics Engineering, The University of Melbourne, Melbourne, VIC 3010, Australia"
            }
        ],
        "venue": "Automatica (Journal of IFAC)",
        "year": 2008
    },
    "ll9F3Ifo": {
        "id": "ll9F3Ifo",
        "title": "On global extremum seeking in the presence of local extrema",
        "abstract": "",
        "keywords": [
            "satisfiability",
            "initial condition",
            "global optimization"
        ],
        "authors": [
            {
                "name": "ying tan",
                "org": "university of melbourne"
            },
            {
                "name": "dragan nesic",
                "org": "university of melbourne"
            },
            {
                "name": "iven mareels",
                "org": "university of melbourne"
            },
            {
                "name": "alessandro astolfi",
                "org": "imperial college london"
            }
        ],
        "venue": "Automatica",
        "year": 2009
    },
    "81Me82hK": {
        "id": "81Me82hK",
        "title": "Model-Guided Data-Driven Decentralized Control for Magnetic Levitation Systems.",
        "abstract": "This paper presents a half bogie model of magnetic levitation systems, which can capture the mechanical coupling between two suspension points. Based on the half bogie model, a model-guided state feedback controller is designed to stabilize the nominal model. A new extended state observer using measured data is proposed to estimate the unknown system state as well as the modeling uncertainties, disturbances, and coupling. This leads to an active disturbance rejection controller that can cancel the effect of unknown disturbances. By incorporating model-guided state feedback controller and the data-driven active disturbance rejection controller with an appropriate tuning of parameters, the closed loop system can track the desired gap up to any given accuracy. Simulation and experimental results demonstrate the effectiveness of the proposed method.",
        "keywords": "",
        "authors": [
            {
                "name": "Qiang Chen",
                "org": "College of Intelligent Science, National University of Defense Technology, Changsha, China"
            },
            {
                "name": "Ying Tan",
                "org": "Melbourne School of Engineering, The University of Melbourne, Melbourne, VIC, Australia"
            },
            {
                "name": "Jie Li",
                "org": ""
            },
            {
                "name": "Denny Oetomo",
                "org": "Melbourne School of Engineering, The University of Melbourne, Melbourne, VIC, Australia"
            },
            {
                "name": "Iven Mareels",
                "org": "Melbourne School of Engineering, The University of Melbourne, Melbourne, VIC, Australia"
            }
        ],
        "venue": "IEEE Access",
        "year": 2018
    },
    "jkO0upx9": {
        "id": "jkO0upx9",
        "title": "On a new uniform dynamic coding algorithm for model-based networked control systems",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "gexia wang",
                "org": "shanghai university of electric power"
            },
            {
                "name": "ying tan",
                "org": "university of melbourne"
            },
            {
                "name": "iven mareels",
                "org": "university of melbourne"
            }
        ],
        "venue": "AuCC",
        "year": 2014
    },
    "w6yk1YaG": {
        "id": "w6yk1YaG",
        "title": "Decentralized PID Control Design for Magnetic Levitation Systems Using Extremum Seeking.",
        "abstract": "A decentralized proportional\u2013integral\u2013differential (PID) control structure has been always the first option for magnetic levitation systems due to its model-free nature as well as the simplicity. It is very challenging to tune PID parameters for each suspension point to ensure that the closed-loop system is less sensitive to uncertainties/disturbances. Even though, by a large number of experiments, a reasonably good PID control parameter set can be obtained to levitate a single suspension point for a given set point, these parameters are very sensitive when the set point changes or the decentralized PID controller is applied to the half bogie where coupling exists, strong oscillations will be observed and retuning of parameters is needed. This paper utilizes the extremum seeking (ES) method to tune PID parameters on-line to improve the steady-state performance of the system with few oscillations. A \u201csampled-data\u201d structure is used to obtain a moving window approximation of the steady-state behavior, leading to a discrete-time ES tuning for the decentralized PID parameters. By using projection method, the tuning parameters are constrained in a compact set, in which the stability can be guaranteed and the optimal performance can be achieved. Experiments have shown the effectiveness of the proposed method.",
        "keywords": "",
        "authors": [
            {
                "name": "Qiang Chen",
                "org": "College of Mechatronics Engineering and Automation, National University of Defense Technology, Changsha, China"
            },
            {
                "name": "Ying Tan",
                "org": "Melbourne School of Engineering, The University of Melbourne, Melbourne, VIC, Australia"
            },
            {
                "name": "Jie Li",
                "org": ""
            },
            {
                "name": "Iven Mareels",
                "org": "Melbourne School of Engineering, The University of Melbourne, Melbourne, VIC, Australia"
            }
        ],
        "venue": "IEEE Access",
        "year": 2018
    },
    "Yy48MYlY": {
        "id": "Yy48MYlY",
        "title": "Indirect Robotic Movement Shaping through Motor Cost Influence.",
        "abstract": "Movement patterns are commonly disrupted after a neurological incident. The correction and recovery of these movement patterns is part of therapeutic practice, and should be considered in the development of robotic device control strategies. This is an area which has limited exploration in rehabilitation robotics literature. This work presents a new strategy aiming at influencing the cost associated with a movement, based on the principle of optimal motor control. This approach is unique, in that it does not directly modify the movement pattern, but instead encourages this altered movement. This 'Indirect Shaping Control' is applied in a preliminary experiment using an end-effector based device with 5 healthy subjects. The study concludes that such an approach may encourage changes in movement patterns which do persist to out-of-robot reaching actions, but this was not consistent over all subjects and further experiments are required.",
        "keywords": "",
        "authors": [
            {
                "name": "Justin Fong",
                "org": "Univeristy of Melbourne - Fourier Intelligence Joint Laboratory, Melbourne School of Engineering, The University of Melbourne, Australia"
            },
            {
                "name": "Vincent Crocher",
                "org": "Univeristy of Melbourne - Fourier Intelligence Joint Laboratory, Melbourne School of Engineering, The University of Melbourne, Australia"
            },
            {
                "name": "Ying Tan",
                "org": "Univeristy of Melbourne - Fourier Intelligence Joint Laboratory, Melbourne School of Engineering, The University of Melbourne, Australia"
            },
            {
                "name": "Denny Oetomo",
                "org": "Univeristy of Melbourne - Fourier Intelligence Joint Laboratory, Melbourne School of Engineering, The University of Melbourne, Australia"
            }
        ],
        "venue": "IEEE ... International Conference on Rehabilitation Robotics : [proceedings]",
        "year": 2019
    },
    "bSjIfz01": {
        "id": "bSjIfz01",
        "title": "A non-gradient approach to global extremum seeking: An adaptation of the Shubert algorithm",
        "abstract": "The main purpose of this paper is to adapt the so-called Shubert algorithm for extremum seeking control of general dynamic plants. This algorithm is a good representative of the ''sampling optimization methods'' that achieve global extremum seeking on compact sets in the presence of local extrema. The algorithm applies to Lipschitz mappings; the model of the system is assumed unknown but the knowledge of its Lipschitz constant is assumed. The controller depends on a design parameter, the ''waiting time'', and tuning guidelines that relate the design parameter and the region of convergence and accuracy of the algorithm are presented. The analysis shows that semi-global practical convergence (in the initial states) to the global extremum can be achieved in presence of local extrema if compact sets of inputs are considered. Numerical simulations for global optimization in the presence of local extrema are provided to demonstrate the proposed approach.",
        "keywords": [
            "Extremum seeking control",
            "Global optimization",
            "Shubert\u2019s algorithm",
            "Lipschitz"
        ],
        "authors": [
            {
                "name": "Dragan Ne\u0161I\u0107",
                "org": "The Department of Electrical & Electronics Engineering, The University of Melbourne, Melbourne, VIC 3010, Australia"
            },
            {
                "name": "Thang Nguyen",
                "org": "The Department of Electrical & Electronics Engineering, The University of Melbourne, Melbourne, VIC 3010, Australia"
            },
            {
                "name": "Ying Tan",
                "org": "The Department of Electrical & Electronics Engineering, The University of Melbourne, Melbourne, VIC 3010, Australia"
            },
            {
                "name": "Chris Manzie",
                "org": "The Department of Mechanical Engineering, The University of Melbourne, Melbourne, VIC 3010, Australia"
            }
        ],
        "venue": "Automatica",
        "year": 2013
    },
    "yZefP4YX": {
        "id": "yZefP4YX",
        "title": "On robustness analysis of linear vibrational control systems.",
        "abstract": "By injecting high frequency dither signals, it is possible to stabilize an inverted pendulum without any feedback. The concept of the vibrational control system is thus proposed to provide extra design freedom in stabilization or other performance indexes. Although various vibrational control algorithms have been proposed and implemented in literature, little work has been done to show their robustness with respect to disturbances and uncertainties. This paper focuses on the robustness analysis of linear vibrational control systems with additive disturbances. By applying perturbation techniques, the linear vibrational control system is shown to be input-to-state stable with respect to disturbances. When disturbances are periodic, frequency analysis technique obtains a less conservative estimate of the ultimate bound of the system, indicating that disturbances with high frequencies lead to relatively small ultimate bounds. When additive state-dependent disturbances are considered, weak averaging techniques can be used to show the robustness of the system when bounded disturbances are slow time-varying. Numerical results support the theoretic analysis.",
        "keywords": [
            "Linear vibrational control",
            "Additive disturbances",
            "Robustness",
            "Averaging"
        ],
        "authors": [
            {
                "name": "Xiaoxiao Cheng",
                "org": "Melbourne School of Engineering, The University of Melbourne, Melbourne, VIC 3010, Australia"
            },
            {
                "name": "Ying Tan",
                "org": "Melbourne School of Engineering, The University of Melbourne, Melbourne, VIC 3010, Australia"
            },
            {
                "name": "Iven Mareels",
                "org": "Melbourne School of Engineering, The University of Melbourne, Melbourne, VIC 3010, Australia"
            }
        ],
        "venue": "Automatica",
        "year": 2018
    },
    "1mKe050Y": {
        "id": "1mKe050Y",
        "title": "Effect Of Arm Deweighting Using End-Effector Based Robotic Devices On Muscle Activity.",
        "abstract": "Deweighting of the limb is commonly performed for patients with a neurological injury, such as stroke, as it allows these patients with limited muscle activity to perform movements. Deweighting has been implemented in exoskeletons and other multi-contact devices, but not on an end-effector based device with single contact point between the assisting robot and the human limb being assisted. This study inves-tigates the effects of deweighting using an end-effector based device on healthy subjects. The muscle activity of five subjects was measured in both static postures and dynamic movements. The results indicate a decrease in the activity of muscles which typically act against gravity - such as the anterior deltoid and the biceps brachii - but also suggest an increase in activity in muscles which act with gravity - such as the posterior deltoid and the lateral triceps. This can be explained by both the change in required muscle-generated torques and a conscious change in approach by the participants. These observations have implications for neurorehabilitation, particularly with respect to the muscle activation patterns which are trained through rehabilitation exercises.",
        "keywords": "",
        "authors": [
            {
                "name": "Justin Fong",
                "org": ""
            },
            {
                "name": "Vincent Crocher",
                "org": ""
            },
            {
                "name": "Raneem Haddara",
                "org": ""
            },
            {
                "name": "David Ackland",
                "org": ""
            },
            {
                "name": "Mary Galea",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Denny Oetomo",
                "org": ""
            }
        ],
        "venue": "EMBC",
        "year": 2018
    },
    "vXohNawH": {
        "id": "vXohNawH",
        "title": "Model-based predictive sampled-data control and its robustness",
        "abstract": "",
        "keywords": [
            "predictive models",
            "matrix decomposition",
            "uncertainty",
            "stability analysis",
            "robustness"
        ],
        "authors": [
            {
                "name": "gexia wang",
                "org": "shanghai university of electric power"
            },
            {
                "name": "ying tan",
                "org": "melbourne school of engineering university of melbourne"
            },
            {
                "name": "iven mareels",
                "org": "melbourne school of engineering university of melbourne"
            }
        ],
        "venue": "ASCC",
        "year": 2015
    },
    "IWME0AiE": {
        "id": "IWME0AiE",
        "title": "Robustness analysis of leader-follower consensus",
        "abstract": "In this paper, robustness properties of the leader-follower consensus are considered. For simplicity of presentation, the attention is focused on a group of continuous-time first-order dynamic agents with a time-invariant communication topology in the presence of communication errors. In order to evaluate the robustness of leader-follower consensus, two robustness measures are proposed: the L 2 gain of the error vector to the state of the network and the worst case L 2 gain at a node. Although the L 2 gain of the error vector to the state of the network is widely used in robust control design and analysis, the worst case L 2 gain at a node is less conservative with respect to the number of nodes in the network. It is thus suggested that the worst case L 2 gain at a node is used when the robustness of consensus is considered. Theoretical analysis and simulation results show that these two measures are sensitive to the communication topology. In general, the \u201coptimal\u201d communication topology that can achieve most robust performance with respect to either of the proposed robustness measures is difficult to characterize and/or obtain. When the in-degree of each follower is one, it is shown that both measures reach a minimum when the leader can communicate to each node in the network.",
        "keywords": [
            "robust control",
            "first order"
        ],
        "authors": [
            {
                "name": "jinzhi wang",
                "org": "peking university"
            },
            {
                "name": "ying tan",
                "org": "university of melbourne"
            },
            {
                "name": "iven mareels",
                "org": "university of melbourne"
            }
        ],
        "venue": "Journal of Systems Science & Complexity",
        "year": 2009
    },
    "bE5cTlxp": {
        "id": "bE5cTlxp",
        "title": "Overcoming overshoot performance limitations of linear systems with reset control.",
        "abstract": "Abstract   It is well-known that for a class of minimum-phase relative degree one linear-time-invariant (LTI) systems, with a unit feedback control structure, overshoot necessarily happens if the plant transfer function has poles at origin or unstable poles. This work aims to overcome this overshoot performance limitation (OPL) by using a novel reset controller, which has a generalized first order reset element (GFORE) structure. By tuning parameters of this reset controller carefully, the non-overshoot performance can be ensured. Furthermore, the implementation of the proposed reset controller with a high-pass filter is provided. Parameter tuning guidelines are also provided and, finally, the proposed design is verified with a simulation example.",
        "keywords": "",
        "authors": [
            {
                "name": "Guanglei Zhao",
                "org": ""
            },
            {
                "name": "Dragan Nesic",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Changchun Hua",
                "org": ""
            }
        ],
        "venue": "Automatica",
        "year": 2019
    },
    "vGobodCg": {
        "id": "vGobodCg",
        "title": "A unifying approach to extremum seeking: Adaptive schemes based on estimation of derivatives",
        "abstract": "",
        "keywords": [
            "gradient descent",
            "steady state",
            "convergence",
            "asymptotic stability",
            "local convergence",
            "tuning",
            "approximation algorithms",
            "approximation theory",
            "adaptive control",
            "continuous optimization",
            "optimal control"
        ],
        "authors": [
            {
                "name": "Dragan Nesic",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "William H. Moase",
                "org": ""
            },
            {
                "name": "Chris Manzie",
                "org": ""
            }
        ],
        "venue": "CDC",
        "year": 2010
    },
    "42Kzr7xh": {
        "id": "42Kzr7xh",
        "title": "On Feedback-Based Iterative Learning Control for Nonlinear Systems Without Global Lipschitz Continuity.",
        "abstract": "Contraction mapping method is widely used in the design and analysis of feed-forward type of iterative learning control (ILC) for a class of nonlinear dynamic systems that satisfy global Lipschitz continuity condition. However, many engineering systems are only locally Lipschitz continuous. Thus contraction mapping method is not directly applicable to such systems. This paper proposes a feedback-based ILC algorithm for a class of nonlinear systems that is only locally Lipschitz continuous. In the proposed feedback-based ILC, the feedforward controller or ILC is designed using a standard contraction mapping technique with an appropriate convergence condition while the feedback control is designed to stabilize the nonlinear dynamic systems. A novel composite energy function is proposed to show that the proposed feedback-based ILC can work even with the input saturation. Simulation results illustrate the effectiveness of the proposed method.",
        "keywords": "",
        "authors": [
            {
                "name": "Gijo Sebastian",
                "org": "The University of Melbourne, Melbourne School of Engineering, Parkville VIC, 3010, Australia"
            },
            {
                "name": "Ying Tan",
                "org": "The University of Melbourne, Melbourne School of Engineering, Parkville VIC, 3010, Australia"
            },
            {
                "name": "Denny Oetomo",
                "org": "The University of Melbourne, Melbourne School of Engineering, Parkville VIC, 3010, Australia"
            },
            {
                "name": "Iven Mareels",
                "org": "The University of Melbourne, Melbourne School of Engineering, Parkville VIC, 3010, Australia"
            }
        ],
        "venue": "ACC",
        "year": 2018
    },
    "JCPzU9aP": {
        "id": "JCPzU9aP",
        "title": "A Unified Analysis Tool in Iterative Learning Control - Composite Energy Function.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Gijo Sebastian",
                "org": "Melbourne School of Engineering, The University of Melbourne, Parkville, VIC, 3010, Australia"
            },
            {
                "name": "Ying Tan",
                "org": "Melbourne School of Engineering, The University of Melbourne, Parkville, VIC, 3010, Australia"
            },
            {
                "name": "Denny Oetomo",
                "org": "Melbourne School of Engineering, The University of Melbourne, Parkville, VIC, 3010, Australia"
            }
        ],
        "venue": "ASCC",
        "year": 2019
    },
    "Yygql6EA": {
        "id": "Yygql6EA",
        "title": "Multidimensional global extremum seeking via the DIRECT optimisation algorithm.",
        "abstract": "DIRECT is a sample-based global optimisation method for Lipschitz continuous functions defined over compact multidimensional domains. This paper adapts the DIRECT method with a modified termination criterion for global extremum seeking control of multivariable dynamical plants. Finite-time semi-global practical convergence is established based on a periodic sampled-data control law, whose sampling period is a parameter which determines the region and accuracy of convergence. A crucial part of the development is dedicated to a robustness analysis of the DIRECT method against bounded additive perturbations on the objective function. Extremum seeking involving multiple units is also considered within the same context as a means to increase the speed of convergence. Numerical examples of global extremum seeking based on DIRECT are presented at the end.",
        "keywords": [
            "Extremum seeking control",
            "Multidimensional global optimisation",
            "DIRECT method",
            "Robustness analysis"
        ],
        "authors": [
            {
                "name": "Sei Zhen Khong",
                "org": ""
            },
            {
                "name": "Dragan Nesic",
                "org": ""
            },
            {
                "name": "Chris Manzie",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            }
        ],
        "venue": "Automatica",
        "year": 2013
    },
    "dX71I6x7": {
        "id": "dX71I6x7",
        "title": "Multi-agent source seeking via discrete-time extremum seeking control.",
        "abstract": "Recent developments in extremum seeking theory have established a general framework for the methodology, although the specific implementations, particularly in the context of multi-agent systems, have not been demonstrated. In this work, a group of sensor-enabled vehicles is used in the context of the extremum seeking problem using both local and global optimisation algorithms to locate the extremum of an unknown scalar field distribution. For the former, the extremum seeker exploits estimates of gradients of the field from local dithering sensor measurements collected by the mobile agents. It is assumed that a distributed coordination which ensures uniform asymptotic stability with respect to a prescribed formation of the agents is employed. An inherent advantage of the frameworks is that a broad range of nonlinear programming algorithms can be combined with a wide class of cooperative control laws to perform extreme source seeking. Semi-global practical asymptotically stable convergence to local extrema is established in the presence of field sampling noise. Subsequently, global extremum seeking with multiple agents is investigated and shown to give rise to robust practical convergence whose speed can be improved via computational parallelism. Nonconvex field distributions with local extrema can be accommodated within this global framework.",
        "keywords": [
            "Extremum seeking",
            "Local and global optimisation",
            "Multi-agent systems",
            "Cooperative control"
        ],
        "authors": [
            {
                "name": "Sei Zhen Khong",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Chris Manzie",
                "org": ""
            },
            {
                "name": "Dragan Nesic",
                "org": ""
            }
        ],
        "venue": "Automatica",
        "year": 2014
    },
    "Pd4z0amf": {
        "id": "Pd4z0amf",
        "title": "adaptationof visuomotor-map uncertainty on visuomotor",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "hiroaki gomi",
                "org": ""
            },
            {
                "name": "huiling tan",
                "org": ""
            },
            {
                "name": "ned jenkinson",
                "org": ""
            },
            {
                "name": "peter brown",
                "org": ""
            },
            {
                "name": "j neurophysiol",
                "org": ""
            },
            {
                "name": "shouhan zhou",
                "org": ""
            },
            {
                "name": "denny oetomo",
                "org": ""
            },
            {
                "name": "ying tan",
                "org": ""
            },
            {
                "name": "iven mareels",
                "org": ""
            },
            {
                "name": "etienne burdet",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2015
    },
    "zlQv5Sh1": {
        "id": "zlQv5Sh1",
        "title": "Magnetic-based Soft Tactile Sensors with Deformable Continuous Force Transfer Medium for Resolving Contact Locations in Robotic Grasping and Manipulation.",
        "abstract": "The resolution of contact location is important in many applications in robotics and automation. This is generally done by using an array of contact or tactile receptors, which increases cost and complexity as the required resolution or area is increased. Tactile sensors have also been developed using a continuous deformable medium between the contact and the receptors, which allows few receptors to interpolate the information among them, avoiding the weakness highlighted in the former approach. The latter is generally used to measure contact force intensity or magnitude but rarely used to identify the contact locations. This paper presents a systematic design and characterisation procedure for magnetic-based soft tactile sensors (utilizing the latter approach with the deformable contact medium) with the goal of locating the contact force location. This systematic procedure provides conditions under which design parameters can be selected, supported by a selected machine learning algorithm, to achieve the desired performance of the tactile sensor in identifying the contact location. An illustrative example, which combines a particular sensor configuration (magnetic hall effect sensor as the receptor, a selected continuous medium and a selected sensing resolution) and a specific data-driven algorithm, is used to illustrate the proposed design procedure. The results of the illustrative example design demonstrates the efficacy of the proposed design procedure and the proposed sensing strategy in identifying a contact location. The resulting sensor is also tested on a robotic hand (Allegro Hand, SimLab Co) to demonstrate its application in real-world scenarios.",
        "keywords": [
            "array of discrete tactile sensors",
            "contact location in tactile sensor",
            "deformable continuous force transfer medium",
            "robotic hand and gripper",
            "soft robotics",
            "soft tactile sensors"
        ],
        "authors": [
            {
                "name": "Alireza Mohammadi",
                "org": "Australian Research Council Centre of Excellence for Electromaterials Science, Wollongong, NSW 2500, Australia."
            },
            {
                "name": "Yangmengfei Xu",
                "org": "Department of Mechanical Engineering, The University of Melbourne, Parkville, VIC 3040, Australia."
            },
            {
                "name": "Ying Tan",
                "org": "Department of Mechanical Engineering, The University of Melbourne, Parkville, VIC 3040, Australia."
            },
            {
                "name": "Peter Choong",
                "org": "Department of Surgery, University of Melbourne, St Vincent's Hospital, Fitzroy, VIC 3065, Australia."
            },
            {
                "name": "Denny Oetomo",
                "org": "Australian Research Council Centre of Excellence for Electromaterials Science, Wollongong, NSW 2500, Australia."
            }
        ],
        "venue": "Sensors",
        "year": 2019
    },
    "n1GTEo9t": {
        "id": "n1GTEo9t",
        "title": "On a shubert algorithm-based global Extremum Seeking Scheme",
        "abstract": "This paper adapts the so-called Shubert algorithm for Extremum Seeking Control (ESC) to seek the global extremum (in presence of local extrema) of general dynamic plants. Different from derivative based methods that are widely used in ESC, the Shubert algorithm is a good representative of sampling optimization methods. With knowledge of the Lipschitz constant of an unknown static mapping, this deterministic algorithm seeks the global extremum. By introducing \u201cwaiting time\u201d the proposed Shubert algorithm-based global extremum seeking guarantees the semi-global practical convergence (in the initial states) to the global extremum if compact sets of inputs are considered. Several numerical examples demonstrate how proposed method may be successfully deployed.",
        "keywords": [
            "deterministic algorithms",
            "optimal control",
            "optimisation",
            "sampling methods",
            "ESC",
            "Lipschitz constant",
            "Shubert algorithm-based global extremum seeking scheme",
            "derivative-based method",
            "deterministic algorithm",
            "dynamic plants",
            "extremum seeking control",
            "sampling optimization method",
            "semiglobal practical convergence",
            "static mapping",
            "waiting time"
        ],
        "authors": [
            {
                "name": "Dragan Nesic",
                "org": "Dept. of Electr. &amp; Electron. Eng., Univ. of Melbourne, Melbourne, VIC, Australia|c|"
            },
            {
                "name": "Thang Nguyen",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Chris Manzie",
                "org": ""
            }
        ],
        "venue": "Decision and Control",
        "year": 2012
    },
    "qtAb4JfF": {
        "id": "qtAb4JfF",
        "title": "Compatible Formation Set for UAVs with Visual Sensing Constraint.",
        "abstract": "Cameras have been applied as one of major sensors on Unmanned Aerial Vehicles (UAVs) for different purposes, for example, as the alternative method for data capturing and communication among UAVs in formation when other sensing and communication resources are not working well. However, the limited Field of View (FOV) of each camera may pose a blinded zone as a visual constraint on the UAVu0027s capability of data capturing and, hence, communication, which may jeopardize practically the group formation of UAVs of the interests. In this paper, a novel concept of the \u2018Compatible Formation\u2019 is proposed on the given limited FOV of a fish-eye camera. It is shown that, if a formation is deemed as compatible under the new concept, a distributed control algorithm could then be developed and applied to steer UAVs to this compatible formation while, simultaneously, keeping each UAV within a visible region of others. The effectiveness of the proposed algorithm is demonstrated in both theoretical analysis and simulations.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaoli Li",
                "org": "Donghua University, School of Information Science and Technology, Shanghai, 201620, China"
            },
            {
                "name": "Ying Tan",
                "org": "The University of Melbourne, Department of Electrical and Electronic Engineering, Parkville, VIC, 3010, Australia"
            },
            {
                "name": "Iven Mareels",
                "org": "The University of Melbourne, Department of Electrical and Electronic Engineering, Parkville, VIC, 3010, Australia"
            },
            {
                "name": "Xiang Chen",
                "org": "University of Windsor, Department of Electrical and Computer Engineering, Windsor, Ontario, Canada"
            }
        ],
        "venue": "ACC",
        "year": 2018
    },
    "DuH9NOJ2": {
        "id": "DuH9NOJ2",
        "title": "On automatic seeking of optimal steady-states in biochemical processes",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "georges bastin",
                "org": ""
            },
            {
                "name": "dragan nesic",
                "org": ""
            },
            {
                "name": "ying tan",
                "org": ""
            },
            {
                "name": "iven mareels",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2007
    },
    "TmwMTtDK": {
        "id": "TmwMTtDK",
        "title": "On the Relationship Between Human Motor Control Performance and Kinematic Synergies in Upper Limb Prosthetics.",
        "abstract": "Current prosthesis command interfaces only allow for a single degree of freedom to be commanded at a time, making coordinated motion difficult to achieve. Thus it becomes crucial to develop methods that complement these interfaces to allow for intuitive coordinated arm motion. Kinematic synergies have been shown as an alternate method where the motion of the prosthetic device is coordinated with that of the residual limb. In this paper, the mapping between the parameters of a kinematic synergy model and a measure of task performance is established experimentally in order to test the applicability of online optimization methods for the identification of synergies. To achieve this, a cost function that captures the objective of the reaching task and a linear kinematic synergy model were chosen. A human experiment was developed in a Virtual Reality (VR) platform in order to determine the synergy-performance relationship. The experiments were performed on 10 able-bodied subjects. The relationship observed between the synergy parameter and the reaching task cost function suggests existing online optimization methods may be applicable.",
        "keywords": "",
        "authors": [
            {
                "name": "Ricardo Garcia-Rosas",
                "org": ""
            },
            {
                "name": "Denny Oetomo",
                "org": ""
            },
            {
                "name": "Chris Manzie",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Peter Choong",
                "org": ""
            }
        ],
        "venue": "EMBC",
        "year": 2018
    },
    "e7tUMztb": {
        "id": "e7tUMztb",
        "title": "Force Observer for an Upper Limb Rehabilitation Robotic Device using Iterative Learning Control.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Gijo Sebastian",
                "org": "Melbourne School of Engineering, The University of Melbourne, Parkville, VIC, 3010, Australia"
            },
            {
                "name": "Zeyu Li",
                "org": "Melbourne School of Engineering, The University of Melbourne, Parkville, VIC, 3010, Australia"
            },
            {
                "name": "Ying Tan",
                "org": "Melbourne School of Engineering, The University of Melbourne, Parkville, VIC, 3010, Australia"
            },
            {
                "name": "Denny Oetomo",
                "org": "Melbourne School of Engineering, The University of Melbourne, Parkville, VIC, 3010, Australia"
            }
        ],
        "venue": "ASCC",
        "year": 2019
    },
    "KgiECIuM": {
        "id": "KgiECIuM",
        "title": "Point-wise Extremum Seeking Control Scheme Under Repeatable Control Environment",
        "abstract": "In this paper, a point-wise extremum seeking control scheme is proposed to seek an optimal trajectory of a time-varying static map under a repeatable control environment. At each time instant, the extremum seeking scheme seeks an optimal value in the optimal trajectory. Under some conditions, it is shown that by tuning the controller parameters properly, the output of the system semi-globally practically uniformly converges to an arbitrarily small neighborhood of the optimal trajectory from an arbitrary initial trajectory. It also shows when a weaker assumption is used, the point-wise extremum seeking controller still ensures that the output converges to the neighborhood of the optimal trajectory when the initial trajectory is sufficiently close to the optimal one.",
        "keywords": [
            "optimal control",
            "time-varying systems",
            "optimal trajectory",
            "convergence",
            "time-varying static map",
            "point-wise extremum seeking control scheme",
            "repeatable control environment"
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Iven Mareels",
                "org": ""
            },
            {
                "name": "Dragan Nesic",
                "org": ""
            },
            {
                "name": "Jian-Xin Xu",
                "org": ""
            }
        ],
        "venue": "ISIC",
        "year": 2007
    },
    "581GtwFc": {
        "id": "581GtwFc",
        "title": "Feedback-Based Iterative Learning Design and Synthesis With Output Constraints for Robotic Manipulators.",
        "abstract": "Feedback-based iterative learning control (ILC) has been proposed to improve the unacceptable transient performance (either in state or in output) in the iteration-domain. This letter addresses a special performance requirement of output constraints, which are motivated from the safety requirements in robotic manipulators. A barrier-function like Lyapunov function is used to design a new state feedback (or a proportional-derivative controller) to ensure that output constraints are satisfied in the finite time-domain. This state feedback is then combined with the standard feed-forward ILC to track the desired trajectory. With the help of composite energy function, it is shown that, for robotic manipulators, the proposed control method can achieve perfect tracking performance without violating output constraints in any iteration. Simulation results, which are based on the model of recently developed rehabilitation robot EMU, are presented to illustrate the effectiveness of the proposed controller.",
        "keywords": "",
        "authors": [
            {
                "name": "Gijo Sebastian",
                "org": "Melbourne School of Engineering, University of Melbourne, Parkville, VIC, Australia"
            },
            {
                "name": "Ying Tan",
                "org": "Melbourne School of Engineering, University of Melbourne, Parkville, VIC, Australia"
            },
            {
                "name": "Denny Oetomo",
                "org": "Melbourne School of Engineering, University of Melbourne, Parkville, VIC, Australia"
            },
            {
                "name": "Iven Mareels",
                "org": "Melbourne School of Engineering, University of Melbourne, Parkville, VIC, Australia"
            }
        ],
        "venue": "IEEE Control Systems Letters",
        "year": 2018
    },
    "M8UqXZLL": {
        "id": "M8UqXZLL",
        "title": "Feature Learning in Assistive Rehabilitation Robotic Systems.",
        "abstract": "Feature learning plays a crucial role in data analysis when the measured data is in a high dimensional space. This paper applied the feature learning technique in data set collected from human movement experiments in an upper limb rehabilitation robotic device. The results showed that the proposed feature learning technique can identify key features to characterize the upper limb movements of humans, even though human variations exist. Four representative features were obtained out of 72 statistic features with very good prediction performance. In future, this feature learning technique can be used in building the link between the movement quality measured from robotic device to the well-known clinic measurements.",
        "keywords": "",
        "authors": [
            {
                "name": "Lei Lu",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Denny Oetomo",
                "org": ""
            },
            {
                "name": "Iven Mareels",
                "org": ""
            },
            {
                "name": "Shi An",
                "org": ""
            }
        ],
        "venue": "EMBC",
        "year": 2018
    },
    "2fM35RWB": {
        "id": "2fM35RWB",
        "title": "Iterative Learning Control and its Applications in Computational Modelling of Human Motor Systems",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ying tan",
                "org": ""
            },
            {
                "name": "c t freeman",
                "org": ""
            },
            {
                "name": "s h zhou",
                "org": ""
            },
            {
                "name": "ronald l davis",
                "org": ""
            },
            {
                "name": "d oetemo",
                "org": ""
            },
            {
                "name": "iven mareels",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "Gwz0GjGM": {
        "id": "Gwz0GjGM",
        "title": "Personalized On-line Adaptation of Kinematic Synergies for Human-Prosthesis Interfaces.",
        "abstract": "Synergies have been adopted in prosthetic limb applications to reduce the complexity of design, but typically involve a single synergy setting for a population and ignore individual preference or adaptation capacity. However, personalization of the synergy setting is necessary for the effective operation of the prosthetic device. Two major challenges hinder the personalization of synergies in human-prosthesis interfaces (HPIs). The first is related to the process of human motor adaptation and the second to the variation in motor learning dynamics of individuals. In this paper, a systematic personalization of kinematic synergies for HPIs using online measurements from each individual is proposed. The task of reaching using the upper limb is described by an objective function and the interface is parameterized by a kinematic synergy. Consequently, personalizing the interface for a given individual can be formulated as finding an optimal personalized parameter. A structure to model the observed motor behavior that allows for the personalized traits of motor preference and motor learning is proposed, and subsequently used in an online optimization scheme to identify the synergies for an individual. The knowledge of the common features contained in the model enables online adaptation of the HPI to happen concurrently to human motor adaptation without the need to retune the personalization algorithm for each individual. Human-in-the-loop experimental results with able-bodied subjects, performed in a virtual reality environment to emulate amputation and prosthesis use, show that the proposed personalization algorithm was effective in obtaining optimal synergies with a fast uniform convergence speed across a group of individuals.",
        "keywords": "",
        "authors": [
            {
                "name": "Ricardo Garcia-Rosas",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Denny Oetomo",
                "org": ""
            },
            {
                "name": "Chris Manzie",
                "org": ""
            },
            {
                "name": "Peter Choong",
                "org": ""
            }
        ],
        "venue": "IEEE transactions on cybernetics",
        "year": 2019
    },
    "wf5HbmA3": {
        "id": "wf5HbmA3",
        "title": "Trajectory Redundancy in Point-to-Point Tracking and Applications to Obstacle Avoidance",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shouhan zhou",
                "org": ""
            },
            {
                "name": "ying tan",
                "org": ""
            },
            {
                "name": "denny oetomo",
                "org": ""
            },
            {
                "name": "c t freeman",
                "org": ""
            },
            {
                "name": "iven mareels",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "knPvR7XV": {
        "id": "knPvR7XV",
        "title": "Simultaneous bioimaging recognition of Al3+ and Cu2+ in living-cell, and further detection of F- and S2- by a simple fluorogenic benzimidazole-based chemosensor",
        "abstract": "A simple Schiff base (BMSA) prepared from salicylaldehyde and 2-(1H-benzo[d]imidazol-2-yl)aniline was evaluated as an efficient fluorescent chemosensor for the selective recognition of Al3+ and Cu2+ over other common metal ions. This sensor could detect Al3+ in CH3OH/PBS with distinct emission red-shift (the detection limit 0.31 mu M)and Cu(2+)in CH3OH/Tris-HCL (the detection limit 0.54 mu M) with obvious fluorescence quenching. The obtained BMSA-Al3+ and BMSA-Cu2+ complexes could act as cascade sensors for detecting F- and S2-, respectively. The recognizing behavior of BMSA toward Al3+ and Cu2+ has been investigated in detail through Job's Plot, FT-IR NMR, and HRMS analysis. Moreover, this chemosensor was verified to be of low cytotoxicity and good imaging characteristics for the detection of Al3+ and Cu2+, and further for the recognition of F- and S2- in living cells, suggesting that BMSA was proved to be a useful tool for tracking Al3+/Cu2+ and F-/S2- ions in vivo. (C) 2016 ElseVier B.V. All rights reserved.",
        "keywords": [
            "-CN- isomerization",
            "Aluminum ion",
            "Benzimidazole-based",
            "Cell imaging",
            "Copper ion",
            "Fluorescence"
        ],
        "authors": [
            {
                "name": "Liu Haiyang",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Construct Base State Key Lab, Shenzhen Key Lab Chem Biol, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Zhang Bibo",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Construct Base State Key Lab, Shenzhen Key Lab Chem Biol, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Tan Chunyan",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Construct Base State Key Lab, Shenzhen Key Lab Chem Biol, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Liu Feng",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Construct Base State Key Lab, Shenzhen Key Lab Chem Biol, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Cao Jiakun",
                "org": "Shenzhen Kivita Innovat Drug Discovery Inst, Shenzhen Technol & Engn Lab Personalized Canc Dia, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Tan Ying",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Construct Base State Key Lab, Shenzhen Key Lab Chem Biol, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Jiang Yuyang",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Construct Base State Key Lab, Shenzhen Key Lab Chem Biol, Shenzhen 518055, Guangdong, Peoples R China; Tsinghua Univ, Sch Med, Dept Pharmacol & Pharmaceut Sci, Beijing 100084, Peoples R China"
            }
        ],
        "venue": "TALANTA",
        "year": 2016
    },
    "B77nHRDM": {
        "id": "B77nHRDM",
        "title": "A simple benzimidazole quinoline-conjugate fluorescent chemosensor for highly selective detection of Ag+",
        "abstract": "A novel and simple fluorescent chemosensor (L), N-((1H-benzo[d]imidazol-2-yl)methyl)quinoline-2-carboxamide, based on quinoline benzimidazole scaffold was synthesized successfully, which had a 'turn-on' effect for Ag+ detection in methanol/Tris buffer(1:1, v/v, pH=7.35) and exhibited a strong fluorescence emission at 357 nm (lambda(ex)=300 nm). The chemosensor had high sensitivity and selectivity for Ag+ even in the presence of other metal ions with the detection limit of 4.4x10(-7) M, which reached the standard of World Health Organization (WHO) for drinking water (5.0x10(-7) M). The mechanism of the interaction between the sensor and Ag+ was investigated in detail through NMR and MALDI Mass spectra analysis. (C) 2016 Elsevier Ltd. All rights reserved.",
        "keywords": [
            "Fluorescence chemosensor",
            "Silver ion",
            "Turn-on effect",
            "High selectivity"
        ],
        "authors": [
            {
                "name": "Chen Changjun",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Chem Biol, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Liu Haiyang",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Chem Biol, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Zhang Bin",
                "org": "Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Chem Biol, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Natl & Local United Engn Lab Personalized Anti Tu, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Wang Yanwei",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Chem Biol, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Cai Kai",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Chem Biol, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Tan Ying",
                "org": "Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Chem Biol, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Natl & Local United Engn Lab Personalized Anti Tu, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Gao Chunmei",
                "org": "Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Chem Biol, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Natl & Local United Engn Lab Personalized Anti Tu, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Liu Hongxia",
                "org": "Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Chem Biol, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Natl & Local United Engn Lab Personalized Anti Tu, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Tan Chunyan",
                "org": "Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Chem Biol, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Natl & Local United Engn Lab Personalized Anti Tu, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Jiang Yuyang",
                "org": "Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Chem Biol, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Natl & Local United Engn Lab Personalized Anti Tu, Shenzhen 518055, Peoples R China; Tsinghua Univ, Sch Med, Beijing 100084, Peoples R China"
            },
            {
                "name": "",
                "org": ""
            }
        ],
        "venue": "TETRAHEDRON",
        "year": 2016
    },
    "QTKlUDjH": {
        "id": "QTKlUDjH",
        "title": "Fluorescence array-based sensing of nitroaromatics using conjugated polyelectrolytes",
        "abstract": "A sensor array consisting of six cationic fluorescent conjugated polyelectrolytes (CPEs) is reported, which could readily differentiate between nine closely related hydrophilic nitroaromatics (NACs) in separate aqueous solutions by fluorescence pattern recognition and linear discrimination analysis (LDA).",
        "keywords": [],
        "authors": [
            {
                "name": "Wu Jiatao",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Tan Chunyan",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Chen Zhifang",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Chen Yu Zong",
                "org": "Shenzhen Kivita Innovat Drug Discovery Inst, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Tan Ying",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Jiang Yuyang",
                "org": "Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China; Tsinghua Univ, Sch Med, Dept Pharmacol & Pharmaceut Sci, Beijing 100084, Peoples R China"
            },
            {
                "name": "",
                "org": ""
            }
        ],
        "venue": "ANALYST",
        "year": 2016
    },
    "PrEiLevz": {
        "id": "PrEiLevz",
        "title": "Proteolysis targeting peptide (PROTAP) strategy for protein ubiquitination and degradation",
        "abstract": "Ubiquitination proteasome pathway (UPP) is the most important and selective way to degrade proteins in vivo. Here, a novel proteolysis targeting peptide (PROTAP) strategy, composed of a target protein binding peptide, a linker and a ubiquitin E3 ligase recognition peptide, was designed to recruit both target protein and E3 ligase and then induce polyubiquitination and degradation of the target protein through UPP. In our study, the PROTAP strategy was proved to be a general method with high specificity using Bcl-xL protein as model target in vitro and in cells, which indicates that the strategy has great potential for in vivo application. (C) 2016 Elsevier Inc. All rights reserved.",
        "keywords": [
            "Ubiquitination",
            "Proteolysis",
            "Proteasome",
            "PROTAP",
            "Bcl-xL"
        ],
        "authors": [
            {
                "name": "Jing Zheng",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Minist Prov Jointly Constructed Base State Key La, Grad Sch Shenzhen, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Chunyan Tan",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Minist Prov Jointly Constructed Base State Key La, Grad Sch Shenzhen, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Pengcheng Xue",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Minist Prov Jointly Constructed Base State Key La, Grad Sch Shenzhen, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Jiakun Cao",
                "org": "Shenzhen Kivita Innovat Drug Discovery Inst, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Feng Liu",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Minist Prov Jointly Constructed Base State Key La, Grad Sch Shenzhen, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Ying Tan",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Minist Prov Jointly Constructed Base State Key La, Grad Sch Shenzhen, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Yuyang Jiang",
                "org": "Tsinghua Univ, Minist Prov Jointly Constructed Base State Key La, Grad Sch Shenzhen, Shenzhen 518055, Guangdong, Peoples R China; Tsinghua Univ, Sch Med, Dept Pharmacol & Pharmaceut Sci, Beijing 100084, Peoples R China"
            }
        ],
        "venue": "BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS",
        "year": 2016
    },
    "MhSFUqLv": {
        "id": "MhSFUqLv",
        "title": "Sensitive Conjugated-Polymer-Based Fluorescent ATP Probes and Their Application in Cell Imaging",
        "abstract": "Three cationic conjugated polyelectrolytes (CPEs) with a common poly(p-phenylene ethynylene terthiophene) backbone and side chains of different lengths, named as PPET3-N1, PPET3-N2, and PPET3-N3, were designed and synthesized. The UV-vis absorption and fluorescence spectra of the polymers vary strongly with solvent composition, suggesting that the polymers are strongly aggregated in H2O. In addition, the spectroscopic properties of the polymers are affected by small-molecule ATP, characterized by significant fluorescence intensity decreases and red shifts of their absorption bands. Further application of these polymers in cell imaging was studied by confocal fluorescence microscopy, which demonstrated that all of the polymers were localized on the cell membrane and partially inside of cells and that the staining effect gradually increased with the length of the polymer side chains. On the basis of the low cytotoxicity and efficient quenching of PPET3-N2 by ATP, the dose and time effects of ATP on PPET3-N2 imaging were studied, and the results indicated that this polymer might have potential in cell imaging for ATP semiquantification in vivo.",
        "keywords": [
            "conjugated polyelectrolytes",
            "ATP",
            "cell imaging",
            "poly(phenylene ethynylene)",
            "polythiophene",
            "aggregation"
        ],
        "authors": [
            {
                "name": "Chen Zhifang",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Chem Biol, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Wu Pan",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Chem Biol, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Cong Rong",
                "org": "Cranbrook Kingswood Upper Sch, Bloomfield Hills, MI 48304 USA"
            },
            {
                "name": "Xu Naihan",
                "org": "Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Chem Biol, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Tan Ying",
                "org": "Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Chem Biol, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Tan Chunyan",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Chem Biol, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Jiang Yuyang",
                "org": "Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Chem Biol, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China; Tsinghua Univ, Sch Med, Dept Pharmacol & Pharmaceut Sci, Beijing 100084, Peoples R China"
            }
        ],
        "venue": "ACS APPLIED MATERIALS & INTERFACES",
        "year": 2016
    },
    "iZIDUROE": {
        "id": "iZIDUROE",
        "title": "Conjugated Polyelectrolyte Nanoparticles for Apoptotic Cell Imaging",
        "abstract": "Three anionic conjugated polyelectrolytes (CPEs) with poly(p-phenylene ethynylene thiophene) backbones were designed and synthesized, among which PPET3-CO2Na showed greater molar extinction coefficient with red-shifted bands in both absorption and emission spectra compared to the well-studied PPE-CO2Na polymer. PPET3-CO2Na was thus chosen to construct CPE-based nanoparticles (CPNs) with cationic octaarginine (R8) peptide through electrostatic-interaction-induced self-assembly. Due to plasma membrane permeabilization and mitochondrial outer membrane permeabilization (MOMP) in early apoptotic cells, PPET3/R8 CPNs demonstrated excellent colocalization with MitoTracker Red in apoptotic cells instead of normal cells, which had potential application in cell imaging for early apoptosis recognition.",
        "keywords": [
            "apoptosis",
            "cell imaging",
            "conjugated polyelectrolytes (CPEs)",
            "conjugated polymer nanoparticles (CPNs)",
            "self-assemble"
        ],
        "authors": [
            {
                "name": "Liu Yu",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Wu Pan",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Jiang Jianhua",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China"
            },
            {
                "name": "Wu Jiatao",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Chen Yan",
                "org": "Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China; Shenzhen Kivita Innovat Drug Discovery Inst, Shenzhen Technol & Engn Lab Personalized Canc Dia, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Tan Ying",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Tan Chunyan",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Jiang Yuyang",
                "org": "Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China; Tsinghua Univ, Sch Med, Dept Pharmacol & Pharmaceut Sci, Beijing 100084, Peoples R China"
            }
        ],
        "venue": "ACS APPLIED MATERIALS & INTERFACES",
        "year": 2016
    },
    "wvYKg38Z": {
        "id": "wvYKg38Z",
        "title": "The Assessment of the Readiness of Molecular Biomarker-Based Mobile Health Technologies for Healthcare Applications.",
        "abstract": "Mobile health technologies to detect physiological and simple-analyte biomarkers have been explored for the improvement and cost-reduction of healthcare services, some of which have been endorsed by the US FDA. Advancements in the investigations of non-invasive and minimally-invasive molecular biomarkers and biomarker candidates and the development of portable biomarker detection technologies have fuelled great interests in these new technologies for mhealth applications. But apart from the development of more portable biomarker detection technologies, key questions need to be answered and resolved regarding to the relevance, coverage, and performance of these technologies and the big data management issues arising from their wide spread applications. In this work, we analyzed the newly emerging portable biomarker detection technologies, the 664 non-invasive molecular biomarkers and the 592 potential minimally-invasive blood molecular biomarkers, focusing on their detection capability, affordability, relevance, and coverage. Our analysis suggests that a substantial percentage of these biomarkers together with the new technologies can be potentially used for a variety of disease conditions in mhealth applications. We further propose a new strategy for reducing the workload in the processing and analysis of the big data arising from widespread use of mhealth products, and discuss potential issues of implementing this strategy.",
        "keywords": [
            "PAPER-BASED ELISA",
            "LINKED IMMUNOSORBENT ASSAYS",
            "HEART-FAILURE",
            "WHOLE-BLOOD",
            "LABEL-FREE",
            "DIAGNOSTICS",
            "SMARTPHONE",
            "DEVICE",
            "POINT",
            "DISEASES"
        ],
        "authors": [
            {
                "name": "Chu Qin",
                "org": ""
            },
            {
                "name": "Lin Tao",
                "org": ""
            },
            {
                "name": "Yik Hui Phang",
                "org": ""
            },
            {
                "name": "Cheng Zhang",
                "org": ""
            },
            {
                "name": "Shang Ying Chen",
                "org": ""
            },
            {
                "name": "Peng Zhang",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Yu Yang Jiang",
                "org": ""
            },
            {
                "name": "Yu Zong Chen",
                "org": ""
            }
        ],
        "venue": "Scientific reports",
        "year": 2015
    },
    "V7MFIT6I": {
        "id": "V7MFIT6I",
        "title": "Fluorophore-Labeling Tetraphenylethene Dyes Ranging from Visible to Near-Infrared Region: AIE Behavior, Performance in Solid State, and Bioimaging in Living Cells.",
        "abstract": "Functional molecules with aggregation-induced emission (AIE) have lately received the most attention due to their versatile functions in many fields. In this work, tetraphenylethene (TPE) as one of the most discussed AIE system was installed on different fluorophores including dansyl, naphthalimide, 4-nitro-1,2,3-benzoxadiazole (NBD), borondipyrromethene, and hemicyanine to afford a series of new fluorescent dyes, whose spectra covered the fluorescence region of the visible to near-infrared emission. Especially, these tetraphenylethene-containing compounds all exhibited AIE behavior. In solid state, they presented multiple colors including blue, orange, red, crimson, and NIR (near-infrared emission). It was worth mentioning that the dansyl- and NBD-coated TPEs exhibited obvious mechanoresponsive luminescence phenomena. Moreover, these AIE-based TPEs displayed a good bioimaging performance in living cells. This work will be helpful for designing functional AIE dyes with different fluorescence emission.",
        "keywords": "",
        "authors": [
            {
                "name": "Weijie Chen",
                "org": "Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry , Central China Normal University , Wuhan 430079 , China."
            },
            {
                "name": "Chen Zhang",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, The Graduate School at Shenzhen , Tsinghua University , Shenzhen 518055 , Guangdong , China."
            },
            {
                "name": "Xie Han",
                "org": "School of Chemistry and Chemical Engineering , Wuhan University of Science and Technology , Wuhan 430081 , China."
            },
            {
                "name": "Sheng Hua Liu",
                "org": "Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Hubei International Scientific and Technological Cooperation Base of Pesticide and Green Synthesis, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry , Central China Normal University , Wuhan 430079 , China."
            },
            {
                "name": "Ying Tan",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, The Graduate School at Shenzhen , Tsinghua University , Shenzhen 518055 , Guangdong , China."
            },
            {
                "name": "Jun Yin",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, The Graduate School at Shenzhen , Tsinghua University , Shenzhen 518055 , Guangdong , China."
            }
        ],
        "venue": "The Journal of organic chemistry",
        "year": 2019
    },
    "jn10KipY": {
        "id": "jn10KipY",
        "title": "A real-time fluorescence turn-on assay for trypsin based on a conjugated polyelectrolyte",
        "abstract": "We report a continuous and sensitive fluorescence turn-on assay for trypsin by using an anionic conjugated polyelectrolyte (PPE-CO2H) and a cationic peptide substrate labelled with p-nitroaniline (RG-pNA). Applications of the assay in trypsin activity study and high-throughput screening of protease inhibitors were demonstrated.",
        "keywords": [
            "PROTEASE ACTIVITY",
            "DNA DETECTION",
            "POLYMERS",
            "WATER",
            "PHOSPHATASE",
            "COMPLEXES",
            "PROTEINS"
        ],
        "authors": [
            {
                "name": "Liu Renxuan",
                "org": "The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China."
            },
            {
                "name": "Tan Ying",
                "org": ""
            },
            {
                "name": "Zhang Cunlong",
                "org": ""
            },
            {
                "name": "Wu Jiatao",
                "org": ""
            },
            {
                "name": "Mei Lin",
                "org": ""
            },
            {
                "name": "Jiang Yuyang",
                "org": ""
            },
            {
                "name": "Tan Chunyan",
                "org": ""
            }
        ],
        "venue": "Journal of materials chemistry. B",
        "year": 2013
    },
    "QkdkMNYj": {
        "id": "QkdkMNYj",
        "title": "Label-free fluorescence detection of circulating microRNAs based on duplex-specific nuclease-assisted target recycling coupled with rolling circle amplification",
        "abstract": "A simpler, more rapid and selective biosensor has been developed for the sensitive detection of circulating miRNAs (c-miRNAs) based on duplex-specific nuclease (DSN)-assisted target recycling coupled with rolling circle amplification (RCA) using SYBR Gold Dye as a signal indicator. This biosensor exhibits a tremendously low detection limit of 0.3 fM of c-miRNAs and shows high selectivity for one-base mismatched c-miRNA. In addition, most importantly, the biosensor could accurately determine the amounts of target c-miRNA in total c-miRNAs isolated from human serums and human cancer cell lines, which confirms that the biosensor could be used to quantify c-miRNAs in complex biological samples and for the clinical early diagnosis of cancers based on c-miRNAs detection. \u00a9 2019",
        "keywords": [
            "Biosensor",
            "Duplex specific nuclease",
            "Rolling circle amplification",
            "Serum circulating microRNAs",
            "SYBR gold dye"
        ],
        "authors": [
            {
                "name": "Fan Tingting",
                "org": "Department of Chemistry, Tsinghua University, Beijing, 100084, China, State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China"
            },
            {
                "name": "Mao Yu",
                "org": "School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China"
            },
            {
                "name": "Liu Feng",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China"
            },
            {
                "name": "Zhang Wei",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China"
            },
            {
                "name": "Lin Jin-Shun",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China"
            },
            {
                "name": "Yin Jingxian",
                "org": "Department of Chemistry, Tsinghua University, Beijing, 100084, China, State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China"
            },
            {
                "name": "Tan Ying",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China"
            },
            {
                "name": "Huang Xiaoting",
                "org": "Department of Chemistry, Tsinghua University, Beijing, 100084, China, State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China"
            },
            {
                "name": "Jiang Yuyang",
                "org": "Department of Chemistry, Tsinghua University, Beijing, 100084, China, State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China"
            }
        ],
        "venue": "Talanta",
        "year": 2019
    },
    "ViXPC4No": {
        "id": "ViXPC4No",
        "title": "A sensitive polymeric dark quencher-based sensing platform for fluorescence \"turn on\" detection of proteins",
        "abstract": "A fluorescence \"turn on\" detection platform for proteins has been developed with high sensitivity and specificity by taking advantage of highly efficient quenching of conjugated polymeric dark quenchers, as well as specific target recognition by either aptamer or peptide substrate probes.",
        "keywords": [],
        "authors": [
            {
                "name": "Lv Ying",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Chem Biol, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Wu Jiatao",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Chem Biol, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Wu Pan",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Chem Biol, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Chen Yu Zong",
                "org": "Shenzhen Kivita Innovat Drug Discovery Inst, Shenzhen Technol & Engn Lab Personalized Canc Dia, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Tan Ying",
                "org": "Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Chem Biol, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Tan Chunyan",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Chem Biol, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Jiang Yuyang",
                "org": "Tsinghua Univ, Grad Sch Shenzhen, Shenzhen Key Lab Chem Biol, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China; Tsinghua Univ, Sch Med, Dept Pharmacol & Pharmaceut Sci, Beijing 100084, Peoples R China"
            },
            {
                "name": "",
                "org": ""
            }
        ],
        "venue": "RSC ADVANCES",
        "year": 2016
    },
    "o4LS6Gkm": {
        "id": "o4LS6Gkm",
        "title": "A new strategy involving the use of peptides and graphene oxide for fluorescence turn-on detection of proteins",
        "abstract": "The detection of proteins is of great biological significance as disease biomarkers in early diagnosis, prognosis tracking and therapeutic evaluation. Thus, we developed a simple, sensitive and universal protein-sensing platform based on peptide and graphene oxide (GO). The design consists of a fluorophore (TAMRA, TAM), a peptide containing eight arginines and peptide ligand that could recognize the target protein, and GO used as a quencher. To demonstrate the feasible use of the sensor for target detection, Bcl-xL was evaluated as the model target. The sensor was proved to be sensitive and applied for the detection of the target proteins in buffer, 2% serum and living cells. \u00a9 2018 by the authors. Licensee MDPI, Basel, Switzerland.",
        "keywords": [
            "GO",
            "ariginines",
            "peptide",
            "selectivity",
            "sensitivity"
        ],
        "authors": [
            {
                "name": "Shi Huan",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Zhang Bibo",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Liu Shuwen",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Tan Chunyan",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Tan Ying",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Jiang Yuyang",
                "org": "The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, China, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China"
            }
        ],
        "venue": "Sensors (Switzerland)",
        "year": 2018
    },
    "p0MrO4kH": {
        "id": "p0MrO4kH",
        "title": "An iminodiacetate-modified conjugated polyelectrolyte for fluorescent labeling of histidine-tagged proteins",
        "abstract": "The iminodiacetate-Ni2+-hexahistidine system is extensively used in protein purification. In this study, an anionic conjugated polyelectrolyte (CPE) with a poly(p-phenylene ethynylene) backbone and iminodiacetate side chains, named PPEIDA, was designed and synthesized. Recognition and visualization of hexahistidine-tagged (His-tagged) proteins using PPEIDA was demonstrated. \u00a9 The Royal Society of Chemistry.",
        "keywords": [],
        "authors": [
            {
                "name": "Cai Kai",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, State Key Laboratory Breeding Base, Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Tan Ying",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, State Key Laboratory Breeding Base, Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Tan Chunyan",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, State Key Laboratory Breeding Base, Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Wu Jiatao",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, State Key Laboratory Breeding Base, Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Wu Pan",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, State Key Laboratory Breeding Base, Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Liang Jiamei",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, State Key Laboratory Breeding Base, Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Liu Shuwen",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, State Key Laboratory Breeding Base, Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Zhang Bibo",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, State Key Laboratory Breeding Base, Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Jiang Yuyang",
                "org": "State Key Laboratory Breeding Base, Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China"
            }
        ],
        "venue": "Chemical Communications",
        "year": 2017
    },
    "gLyi4mwb": {
        "id": "gLyi4mwb",
        "title": "Light-Induced Translocation of a Conjugated Polyelectrolyte in Cells: From Fluorescent Probe to Anticancer Agent",
        "abstract": "Dual-functional probes, which not only enable visualization of diseased cells but also induce therapeutic cellular responses, are essential to biological studies. In the current work, a conjugated polyelectrolyte, PPET3-N2, was designed and synthesized as a dual-functional probe. The poly(phenylene ethynylene) terthiophene polymer backbone contributes to the polymer's light-harvesting property to ensure the strong fluorescence as well as photosensitization, whereas quantanary ammonium side chains interact with target organelle for localization. As a fluorescent probe, PPET3-N2 was endocytosed to lysosomes through clathrin-mediated endocytosis (CME) and macropinocytosis (MPC) pathways. Colocalization of the probe with commercial fluorescent lysosome labels confirmed that this probe localized on lysosomes with high specificity and photostability. Real-time monitoring of autolysosome formation in autophagic cells was also demonstrated, providing a viable platform for cell-based screening of autophagy inhibitors. Finally, as a photosensitizer, PPET3-N2 can efficiently generate singlet oxygen in living cells upon irradiation of white light, leading to the destruction of lysosome membrane and release of ROS and lysosomal enzymes in cytoplasma, causing cell death. \u00a9 2017 American Chemical Society.",
        "keywords": [
            "autolysosome",
            "autophagy",
            "conjugated polyelectrolyte",
            "singlet oxygen",
            "translocation"
        ],
        "authors": [
            {
                "name": "Wu Pan",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, State Key Laboratory Breeding Base-Shenzhen, Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Xu Naihan",
                "org": "Open FIESTA Center, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China, Key Lab in Health Science and Technology, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Tan Chunyan",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, State Key Laboratory Breeding Base-Shenzhen, Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China, Open FIESTA Center, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Liu Lei",
                "org": "Key Lab in Health Science and Technology, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Tan Ying",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, State Key Laboratory Breeding Base-Shenzhen, Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China, Open FIESTA Center, Division of Life Science, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Chen Zhifang",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, State Key Laboratory Breeding Base-Shenzhen, Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Jiang Yuyang",
                "org": "School of Pharmaceutical Sciences, Tsinghua University, Beijing, China, State Key Laboratory Breeding Base-Shenzhen, Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            }
        ],
        "venue": "ACS Applied Materials and Interfaces",
        "year": 2017
    },
    "CuUhGYMK": {
        "id": "CuUhGYMK",
        "title": "Fluorescence array-based sensing of metal ions using conjugated polyelectrolytes.",
        "abstract": "Array-based sensing offers several advantages for detecting a series of analytes with common structures or properties. In this study, four anionic conjugated polyelectrolytes (CPEs) with a common poly(p-pheynylene ethynylene) (PPE) backbone and varying pendant ionic side chains were designed. The conjugation length, repeat unit pattern, and ionic side chain composition were the main factors affecting the fluorescence patterns of CPE polymers in response to the addition of different metal ions. Eight metal ions, including Pb(2+), Hg(2+), Fe(3+), Cr(3+), Cu(2+), Mn(2+), Ni(2+), and Co(2+), categorized as water contaminants by the Environmental Protection Agency, were selected as analytes in this study. Fluorescence intensity response patterns of the four-PPE sensor array toward each of the metal ions were recorded, analyzed, and transformed into canonical scores using linear discrimination analysis (LDA), which permitted clear differentiation between metal ions using both two-dimensional and three-dimensional graphs. In particular, the array could readily differentiate between eight toxic metal ions in separate aqueous solutions at 100 nM. Our four-PPE sensor array also provides a practical application to quantify Pb(2+) and Hg(2+) concentrations in blind samples within a specific concentration range.",
        "keywords": [
            "COLORIMETRIC SENSOR ARRAY",
            "CHEMICAL SENSORS",
            "GOLD-NANOPARTICLE",
            "ENERGY MIGRATION",
            "STRANDED-DNA",
            "POLYMERS",
            "WATER",
            "RECOGNITION",
            "PROTEINS",
            "IDENTIFICATION"
        ],
        "authors": [
            {
                "name": "Yi Wu",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Jiatao Wu",
                "org": ""
            },
            {
                "name": "Shangying Chen",
                "org": ""
            },
            {
                "name": "Yu Zong Chen",
                "org": ""
            },
            {
                "name": "Xinwen Zhou",
                "org": ""
            },
            {
                "name": "Yuyang Jiang",
                "org": ""
            },
            {
                "name": "Chunyan Tan",
                "org": ""
            }
        ],
        "venue": "ACS applied materials & interfaces",
        "year": 2015
    },
    "wGh7NPDt": {
        "id": "wGh7NPDt",
        "title": "UBE2J2 promotes hepatocellular carcinoma cell epithelial-mesenchymal transition and invasion in vitro .",
        "abstract": "Ubiquitin-conjugating enzyme E2 J2 (UBE2J2) is an ubiquitin proteasome component that responds to proteotoxic stress. We found that UBE2J2 was highly expressed in cellular protrusions of HCCLM3 metastatic hepatocellular carcinoma (HC) cells. Immunohistochemical analyses showed that UBE2J2 was expressed at higher levels in HC patient tissues than in corresponding non-tumor tissues. Because cellular protrusions are important for cell invasion, we hypothesized that UBE2J2 promotes HC cell invasion. We used chip-based surface plasmon resonance (SPR) to assess possible mechanisms of UBE2J2-regulated HCCLM3 cell invasion. We found that p-EGFR interacted with UBE2J2, and this finding was confirmed by co-immunoprecipitation analysis. UBE2J2 overexpression activated endothelial-mesenchymal transition in the non-invasive SMMC7721 HC cell line, and promoted invasion. UBE2J2 silencing reduced HCCLM3 cell invasion and endocytosis, and downregulated p-EGFR expression. p-EGFR inhibition by lapatinib reduced UBE2J2-promoted cell invasion, suggesting p-EGFR is important for UBE2J2-mediated HCCLM3 cell invasion. These findings demonstrate that endocytosis by HC cells is closely related to invasion, and may provide new anti-HC therapeutic targets. UBE2J2 may also be a novel biomarker for clinical HC diagnosis.",
        "keywords": [
            "hepatocellular carcinoma",
            "UBE2J2",
            "epithelial-mesenchymal transition",
            "EGFR",
            "invasion"
        ],
        "authors": [
            {
                "name": "Chen Shaopeng",
                "org": "Tsinghua Univ, Grad Sch Shenzhen, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Tan Ying",
                "org": "Tsinghua Univ, Grad Sch Shenzhen, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Deng Haihua",
                "org": "Fuyong Hosp, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Shen Zhifa",
                "org": "Wenzhou Med Univ, Sch Lab Med & Life Sci, Zhejiang Prov Key Lab Med Genet, Key Lab Lab Med,Minist Educ China, Wenzhou 325035, Peoples R China"
            },
            {
                "name": "Liu Yanhong",
                "org": "Tsinghua Univ, Grad Sch Shenzhen, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Wu Pan",
                "org": "Tsinghua Univ, Grad Sch Shenzhen, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Tan Chunyan",
                "org": "Tsinghua Univ, Grad Sch Shenzhen, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Jiang Yuyang",
                "org": "Tsinghua Univ, Sch Pharmaceut Sci, Beijing 100084, Peoples R China"
            },
            {
                "name": "",
                "org": ""
            }
        ],
        "venue": "ONCOTARGET",
        "year": 2017
    },
    "iErJKC63": {
        "id": "iErJKC63",
        "title": "Photodynamic therapy based on organic small molecular fluorescent dyes",
        "abstract": "Photodynamic therapy (PDT)has shown promise as an effective treatment modality for cancer and other localized diseases due to its noninvasive properties and spatiotemporal selectivity. Near-infrared (NIR)fluorescent dyes based on organic small molecules are characterized with low cytotoxicity, good biocompatibility and excellent phototoxicity, which are widely used in PDT. In this review, we attempt to summarize the development of imaging-induced PDT based on organic small molecules and classify it according to the structures of dyes including cyanines, 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)analogues, phthalocyanine and other agents such as rhodamine analogues. \u00a9 2019",
        "keywords": [
            "BODIPY",
            "Cyanine",
            "Near-infrared fluorescent dyes",
            "Photodynamic therapy",
            "Phthalocyanine"
        ],
        "authors": [
            {
                "name": "Li Li",
                "org": ""
            },
            {
                "name": "Yisha Chen",
                "org": ""
            },
            {
                "name": "Weijie Chen",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Haiyan Chen",
                "org": ""
            },
            {
                "name": "Jun Yin",
                "org": ""
            }
        ],
        "venue": "Chinese Chemical Letters",
        "year": 2019
    },
    "gmsTGjJg": {
        "id": "gmsTGjJg",
        "title": "Tissue-Imaging of Glutathione-Specifical Naphthalimide-Cyanine Dye with Two-Photon and Near-Infrared Manners.",
        "abstract": "Molecular probes suitable for different fluorescence imaging technologies can meet the requirements of different scientific researches in biological applications. In this work, a naphthalimide-cyanine based sulfonamide was used to specifically visualize the glutathione of mouse tissues with a two-photon manner for the naphthalimide moiety and a near-infrared manner for the cyanine moiety, respectively. The results showed that this probe served as a dual-model tissue-imaging agent for the visualization of glutathione with around 200 \u03bcm imaging depth in two-photon manner and 120 \u03bcm imaging depth in near-infrared manner, respectively, which provided a model for the tissue-imaging in visible and near-infrared channels.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhiqiang Xu",
                "org": "Central China Normal University"
            },
            {
                "name": "Xiaoting Huang",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong 518055, People\u2019s Republic of China"
            },
            {
                "name": "Ming-Xing Zhang",
                "org": "Central China Normal University"
            },
            {
                "name": "Weijie Chen",
                "org": "Central China Normal University"
            },
            {
                "name": "Sheng Hua Liu",
                "org": "Central China Normal University"
            },
            {
                "name": "Ying Tan",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong 518055, People\u2019s Republic of China"
            },
            {
                "name": "Jun Yin",
                "org": "Central China Normal University"
            }
        ],
        "venue": "Analytical chemistry",
        "year": 2019
    },
    "ldc26nSR": {
        "id": "ldc26nSR",
        "title": "Recent advances in formaldehyde-responsive fluorescent probes",
        "abstract": "Formaldehyde, as one of the simplest reactive carbonyl species (RCS), is regarded as a potential carcinogen and a sick house syndrome gas. Recent studies have shown that abnormally high levels of formaldehyde may result in cognitive decline and spatial memory deficits, asthmatic symptoms, Alzheimer's disease, and cancer. Due to the harmfulness of high levels of formaldehyde in nature and humans, it is of great significance to further elucidate the roles and functions of formaldehyde by a non-invasive detection approach. Fluorescence imaging has become a powerful and popular tool in monitoring bio-species owing to their high sensitivity and selectivity, excellent spatiotemporal resolution and non-invasion nature. Therefore, fluorescent probes are widely applied to track and detect formaldehyde in vitro and in vivo which have attracted more and more interest recently. This review focuses on various strategies to design the fluorescent probes for detecting formaldehyde based on different recognition groups. \u00a9 2017 The Author",
        "keywords": [
            "Bioimaging application",
            "Fluorescent probes",
            "Formaldehyde",
            "Sensing mechanism"
        ],
        "authors": [
            {
                "name": "Xu Zhiqiang",
                "org": "Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China"
            },
            {
                "name": "Chen Jianhua",
                "org": "Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China"
            },
            {
                "name": "Hu Lin-Li",
                "org": "College of Chemistry Environmental Engineering, Yangtze University, Jingzhou, China"
            },
            {
                "name": "Tan Ying",
                "org": "The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Liu Sheng-Hua",
                "org": "Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China"
            },
            {
                "name": "Yin Jun",
                "org": "The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China, Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China"
            }
        ],
        "venue": "Chinese Chemical Letters",
        "year": 2017
    },
    "N8zRXaIm": {
        "id": "N8zRXaIm",
        "title": "Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting.",
        "abstract": "Many drugs are nature derived. Low drug productivity has renewed interest in natural products as drug-discovery sources. Nature-derived drugs are composed of dozens of molecular scaffolds generated by specific secondary-metabolite gene clusters in selected species. It can be hypothesized that drug-like structures probably are distributed in selective groups of species. We compared the species origins of 939 approved and 369 clinical-trial drugs with those of 119 preclinical drugs and 19,721 bioactive natural products. In contrast to the scattered distribution of bioactive natural products, these drugs are clustered into 144 of the 6,763 known species families in nature, with 80% of the approved drugs and 67% of the clinical-trial drugs concentrated in 17 and 30 drug-prolific families, respectively. Four lines of evidence from historical drug data, 13,548 marine natural products, 767 medicinal plants, and 19,721 bioactive natural products suggest that drugs are derived mostly from preexisting drug-productive families. Drug-productive clusters expand slowly by conventional technologies. The lack of drugs outside drug-productive families is not necessarily the result of under-exploration or late exploration by conventional technologies. New technologies that explore cryptic gene clusters, pathways, interspecies crosstalk, and high-throughput fermentation enable the discovery of novel natural products. The potential impact of these technologies on drug productivity and on the distribution patterns of drug-productive families is yet to be revealed.",
        "keywords": [
            "ASPERGILLUS-NIDULANS",
            "CLINICAL-TRIALS",
            "PRODUCTS",
            "DISCOVERY",
            "METABOLITES",
            "THERAPEUTICS",
            "BIOSYNTHESIS",
            "MOLECULES",
            "FRONTIER",
            "DATABASE"
        ],
        "authors": [
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Chu Qin",
                "org": ""
            },
            {
                "name": "Lin Tao",
                "org": ""
            },
            {
                "name": "Xin Liu",
                "org": ""
            },
            {
                "name": "Zhe Shi",
                "org": ""
            },
            {
                "name": "Xiaohua Ma",
                "org": ""
            },
            {
                "name": "Jia Jia",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Cheng Cui",
                "org": ""
            },
            {
                "name": "Jinshun Lin",
                "org": ""
            },
            {
                "name": "Chunyan Tan",
                "org": ""
            },
            {
                "name": "Yuyang Jiang",
                "org": ""
            },
            {
                "name": "Yuzong Chen",
                "org": ""
            }
        ],
        "venue": "Proceedings of the National Academy of Sciences of the United States of America",
        "year": 2011
    },
    "9R45Vv9A": {
        "id": "9R45Vv9A",
        "title": "p38 beta, A Novel Regulatory Target of Pokemon in Hepatic Cells",
        "abstract": "Pokemon is an important proto-oncogene involved in various biological processes and cancer development, such as cell differentiation, tumorigenesis and metastasis. Pokemon is recognized as a transcription factor localized upstream of several oncogenes, regulating their expression. p38MAPKs act as key regulatory factors in cellular signaling pathways associated with inflammatory responses, cell proliferation, differentiation and survival. p38 beta, a member of p38MAPK family, is closely correlated with tumorigenesis, but the mechanism of activation remains unclear. In this study, we found overexpression of Pokemon promoted the growth, migration and invasion of HepG2 cells. However, a p38 inhibitor SB202190 efficiently attenuated the promoting effect of Pokemon in the HepG2 cells. Targeted expression or silencing of Pokemon changed cellular p38 beta protein level and phosphorylation of downstream ATF2 in the p38 signaling pathway. Both dual luciferase report assay and ChIP assay suggested that p38 beta is a novel regulatory target of the transcription factor Pokemon and positively regulated by Pokemon in hepatic cells.",
        "keywords": [
            "ACTIVATED PROTEIN-KINASE",
            "P38 MAP-KINASES",
            "REPRESSES TRANSCRIPTION",
            "TUMOR-SUPPRESSOR",
            "FBI-1",
            "STRESS",
            "APOPTOSIS",
            "GENE",
            "INHIBITION",
            "EXPRESSION"
        ],
        "authors": [
            {
                "name": "Chen Zhe",
                "org": ""
            },
            {
                "name": "Liu Feng",
                "org": ""
            },
            {
                "name": "Zhang Nannan",
                "org": ""
            },
            {
                "name": "Cao Deliang",
                "org": ""
            },
            {
                "name": "Liu Min",
                "org": ""
            },
            {
                "name": "Tan Ying",
                "org": ""
            },
            {
                "name": "Jiang Yuyang",
                "org": ""
            }
        ],
        "venue": "International Journal of Molecular Sciences",
        "year": 2013
    },
    "ihfzyAqB": {
        "id": "ihfzyAqB",
        "title": "Molecular weight analysis of water-soluble poly(phenylene ethynylene)s using MALDI-TOF MS",
        "abstract": "Molecular weights of seven poly(phenylene ethynylene)-based water-soluble conjugated polyelectrolytes (CPEs) obtained through Sonogashira coupling are determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). A standard sample preparation protocol is developed to characterize the seven CPEs using 2,5-dihydroxybenzoic acid as the matrix (M) and AgTFA as the cationization reagent (CR). High-quality MALDI mass spectra are obtained at volume mixing ratios (CPE/M/CR) of 5/5/1 for anionic polymers (P1\u2013P4) and 5/50/1 for cationic polymers (P5\u2013P7). Molecular weight, molecular weight distribution, and end-group information are analyzed. The effects of molecular weight of CPEs on optical and quenching properties are also studied. \u00a9 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 2537\u20132543. \u00a9 2017 Wiley Periodicals, Inc.",
        "keywords": [
            "CPEs",
            "MALDI-TOF MS",
            "molecular weight determination",
            "optical properties"
        ],
        "authors": [
            {
                "name": "Wu Jiatao",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Tan Chunyan",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Zhou Xinwen",
                "org": "Institutes of Biomedical Sciences, Fudan University, Shanghai, China"
            },
            {
                "name": "Tan Ying",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Yang Pengyuan",
                "org": "Institutes of Biomedical Sciences, Fudan University, Shanghai, China"
            },
            {
                "name": "Jiang Yuyang",
                "org": "The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, China, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, China"
            }
        ],
        "venue": "Journal of Polymer Science, Part A: Polymer Chemistry",
        "year": 2017
    },
    "Ua7JH7w9": {
        "id": "Ua7JH7w9",
        "title": "The optimization and characterization of an RNA-cleaving fluorogenic DNAzyme probe for MDA-MB-231 cell detection",
        "abstract": "Breast cancer is one of the most frequently diagnosed cancers in females worldwide and lacks specific biomarkers for early detection. In a previous study, we obtained a selective RNAcleaving Fluorogenic DNAzyme (RFD) probe against MDA-MB-231 cells, typical breast cancer cells, through the systematic evolution of ligands by exponential process (SELEX). To improve the performance of this probe for actual application, we carried out a series of optimization experiments on the pH value of a reaction buffer, the type and concentration of cofactor ions, and sequence minimization. The length of the active domain of the probe reduced to 25 nt from 40 nt after optimization, which was synthesized more easily and economically. The detection limit of the optimized assay system was 2000 MDA-MB-231 cells in 30 min, which is more sensitive than the previous one (almost 5000 cells). The DNAzyme probe was also capable of distinguishing MDAMB-231 cell specifically from 3 normal cells and 10 other tumor cells. This probe with high sensitivity, selectivity, and economic efficiency enhances the feasibility for further clinical application in breast cancer diagnosis. Herein, we developed an optimization system to produce a general strategy to establish an easy-to-use DNAzyme-based assay for other targets. \u00a9 2017 by the authors. Licensee MDPI, Basel, Switzerland.",
        "keywords": [
            "DNAzyme",
            "MDA-MB-231 cell",
            "RFD probe",
            "optimization"
        ],
        "authors": [
            {
                "name": "Xue Pengcheng",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Shenzhen Tsinghua Univ, Minist Prov Jointly Constructed Base, State Key Lab Shenzhen, Grad Sch Shenzhen,Key Lab Chem Biol, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "He Shengnan",
                "org": "Shenzhen Tsinghua Univ, Minist Prov Jointly Constructed Base, State Key Lab Shenzhen, Grad Sch Shenzhen,Key Lab Chem Biol, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Mao Yu",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Shenzhen Tsinghua Univ, Minist Prov Jointly Constructed Base, State Key Lab Shenzhen, Grad Sch Shenzhen,Key Lab Chem Biol, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Qu Long",
                "org": "Shenzhen Tsinghua Univ, Minist Prov Jointly Constructed Base, State Key Lab Shenzhen, Grad Sch Shenzhen,Key Lab Chem Biol, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Liu Feng",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Shenzhen Tsinghua Univ, Minist Prov Jointly Constructed Base, State Key Lab Shenzhen, Grad Sch Shenzhen,Key Lab Chem Biol, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Tan Chunyan",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Shenzhen Tsinghua Univ, Minist Prov Jointly Constructed Base, State Key Lab Shenzhen, Grad Sch Shenzhen,Key Lab Chem Biol, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Jiang Yuyang",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Shenzhen Tsinghua Univ, Minist Prov Jointly Constructed Base, State Key Lab Shenzhen, Grad Sch Shenzhen,Key Lab Chem Biol, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Tan Ying",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Shenzhen Tsinghua Univ, Minist Prov Jointly Constructed Base, State Key Lab Shenzhen, Grad Sch Shenzhen,Key Lab Chem Biol, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "",
                "org": ""
            }
        ],
        "venue": "Sensors (Switzerland)",
        "year": 2017
    },
    "5012e5UJ": {
        "id": "5012e5UJ",
        "title": "Naphthalimide-containing conjugated polyelectrolytes with different chain configurations",
        "abstract": "Several donor-acceptor type conjugated polyelectrolytes containing naphthalimide are developed. Different polymer chain configurations of the backbones of polymers lead to different photophysical properties. The para-substituted polymers show extended conformations with quite low quantum yields in high polarity solvents because of twisted intramolecular charge transfer features, while the meta-substituted polymers can form helices and demonstrated significantly improved quantum yields in water and methanol, as well as achieving sensitive, ultrafast and ratiometric detection of trace methylene blue in water. \u00a9 2019 The Royal Society of Chemistry.",
        "keywords": [],
        "authors": [
            {
                "name": "Chen Yu",
                "org": "Department of Chemistry, Tsinghua University, Beijing, 100084, China, State Key Laboratory of Chemical Oncogenomics, Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China"
            },
            {
                "name": "Tan Ying",
                "org": "Department of Chemistry, Tsinghua University, Beijing, 100084, China, State Key Laboratory of Chemical Oncogenomics, Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China"
            },
            {
                "name": "Tan Chunyan",
                "org": "Department of Chemistry, Tsinghua University, Beijing, 100084, China, State Key Laboratory of Chemical Oncogenomics, Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China"
            },
            {
                "name": "Lu Yunpeng",
                "org": "Division of Chemistry and Biochemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637371, Singapore"
            },
            {
                "name": "Chen Yuzong",
                "org": "State Key Laboratory of Chemical Oncogenomics, Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China"
            },
            {
                "name": "Jiang Yuyang",
                "org": "State Key Laboratory of Chemical Oncogenomics, Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China, School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China"
            }
        ],
        "venue": "Organic and Biomolecular Chemistry",
        "year": 2019
    },
    "BIbvA1oB": {
        "id": "BIbvA1oB",
        "title": "Site-directed mutagenesis study of the Ile140 in conserved hydrophobic core of Bcl-x(L).",
        "abstract": "The hydrophobic core in Bcl-x(L) composed of Trp137, Ile140, Trp181, Ile182, Trp188 and Phe191 is highly conserved and essential for protein folding, protein stability and binding affinity with BH3-peptide. 9 mutants of Ile140 residue were constructed and characterized in order to get better understanding of the effect of the hydrophobic core. Binding assay demonstrated that binding affinities between 4 charged mutants and BH3-peptide were significantly weakened or lost, suggesting that the integrity of the hydrophobic core has close relationship with binding. The CD spectroscopy results indicated that disruption of the hydrophobic core may affect local conformation within the protein and result in intrinsic inactivity. Further chemical-induced protein folding results on these 4 mutants revealed that the conserved hydrophobic core is also important for the protein stability.",
        "keywords": [
            "BCL-2 FAMILY-MEMBERS",
            "PEPTIDE COMPLEX",
            "BH3 DOMAIN",
            "PROTEIN FAMILY",
            "APOPTOSIS",
            "DEATH",
            "PATHWAY",
            "FORMS",
            "BAX"
        ],
        "authors": [
            {
                "name": "Xin Zhang",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Rui Zhao",
                "org": ""
            },
            {
                "name": "Bizhu Chu",
                "org": ""
            },
            {
                "name": "Chunyan Tan",
                "org": ""
            },
            {
                "name": "Yuyang Jiang",
                "org": ""
            }
        ],
        "venue": "Protein and peptide letters",
        "year": 2012
    },
    "Ta0Q6nxt": {
        "id": "Ta0Q6nxt",
        "title": "A simple amide fluorescent sensor based on quinoline for selective and sensitive recognition of zinc(II) ions and bioimaging in living cells",
        "abstract": "A simple quinoline-based derivative (AQDPA) was developed as a highly efficient fluorescent sensor for sensing Zn2+ and sequential recognition of pyrophosphate and sulfur ions. This chemosensor was synthesized from diisopropylamine and 2-chloro-N-(quinolin-8-yl)acetamide. The non-fluorescence sensor displayed significant and specific fluorescence enhancement after binding to Zn2+ with high selectivity. The fluorescence titration analysis shows a detection limit for Zn2+ at 4.1 \u00d7 10\u22128 M. The sensing mechanisms of AQDPA binding to Zn2+ were supported by 1H NMR, HR-MS analysis, and density functional theory (DFT) study. Moreover, the fluorescence imaging in HeLa cells suggested that this simple sensor had great potential in the application of biological imaging. \u00a9 2018 Elsevier Ltd",
        "keywords": [
            "DFT",
            "Fluorescence imaging",
            "Fluorescent sensor",
            "Quinoline",
            "Zinc ion"
        ],
        "authors": [
            {
                "name": "Liu Haiyang",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, China, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, Hong Kong"
            },
            {
                "name": "Tan Ying",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, Advanced Materials Institute, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Dai Qiuzi",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, Advanced Materials Institute, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Liang Hongda",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, China"
            },
            {
                "name": "Song Jun",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, China"
            },
            {
                "name": "Qu Junle",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, China"
            },
            {
                "name": "Wong Wai-Yeung",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, China, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, Hong Kong"
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2018
    },
    "kHFik6TU": {
        "id": "kHFik6TU",
        "title": "A Visible and Near-Infrared, Dual-Channel Fluorescence-On Probe for Selectively Tracking Mitochondrial Glutathione",
        "abstract": "Glutathione is a major endogenous antioxidant in biological systems. As a result, highly selective fluorescent probes are significant components of studies aimed at gaining a better understanding of the role(s) glutathione plays in biological functions. In this study, we developed a dual-channel turn-on fluorescent probe for glutathione, comprising naphthalimide and cyanine, bridged by a thiol-reactive sulfonamide moiety. The probe selectively responds to glutathione and is not affected by cysteine and homocysteine. Important information has been gained about the chemical mechanism for operation of the probe, which responds to glutathione in visible and near-infrared channels synchronously and independently. Moreover, this probe exhibits the remarkable capability of targeting mitochondria and dual-channel tracking of intracellular glutathione in a spatiotemporal and synchronous manner. We believe that the strategy used to design the new dual-channel fluorescence-on probe will be applicable to the design of fluorescent probes that display specific responses in multiple channels. \u00a9 2018 Elsevier Inc.Glutathione (GSH), as the most abundant intracellular biothiol, participates in many physiological processes. Aberrant levels of cellular GSH are closely associated with a variety of diseases, so GSH can be considered a significant biomarker for the health of humans. Accordingly, developing specific fluorescent probes to assess the cellular function and distribution of GSH is of great significance. Here, a unique sensing model is accomplished; the developed probe displays high selectivity toward glutathione in both visible and near-infrared channels, and the sensing mechanism is elucidated. Bioimaging shows that this probe possesses excellent capability for mitochondria localization and can selectively monitor intracellular glutathione in dual channels in a spatiotemporal and synchronous manner.A naphthalimide- and cyanine-dressing fluorescent probe is utilized to specifically and selectively detect glutathione in both visible and near-infrared channels, respectively. Cell imaging indicates that this probe can target mitochondria and track intracellular glutathione in dual channels in a spatiotemporal and synchronous manner.",
        "keywords": [
            "cyanine",
            "dual-channel fluorescence on",
            "fluorescent probe",
            "glutathione",
            "mitochondria-targeting",
            "naphthalimide",
            "SDG3: Good health and well-being"
        ],
        "authors": [
            {
                "name": "Xu Z.",
                "org": "Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China"
            },
            {
                "name": "Huang X.",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            },
            {
                "name": "Han X.",
                "org": "Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China"
            },
            {
                "name": "Wu D.",
                "org": "Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China"
            },
            {
                "name": "Zhang B.",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            },
            {
                "name": "Tan Y.",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            },
            {
                "name": "Cao M.",
                "org": "Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China"
            },
            {
                "name": "Liu S.H.",
                "org": "Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China"
            },
            {
                "name": "Yin J.",
                "org": "Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China"
            },
            {
                "name": "Yoon J.",
                "org": "Department of Chemistry and Nano Science, Ewha Womans University, Seoul, South Korea"
            }
        ],
        "venue": "Chem",
        "year": 2018
    },
    "tL1RnQpC": {
        "id": "tL1RnQpC",
        "title": "A dual-response quinoline-based fluorescent sensor for the detection of Copper (II) and Iron(III) ions in aqueous medium",
        "abstract": "A new and dual-response fluorescent probe (QLBM) based on quinoline and benzimidazole groups has been designed and developed for recognition of copper(II) ion (Cu2+) and iron(III) ion (Fe3+) simultaneously. This sensor displays a favorable selectivity for Cu2+ and Fe3+ ions over a range of other common metal cations in 100% aqueous medium (50 mM Tris buffer, pH 7.2), leading to prominent fluorescence on-off. The detection limits were 1.35 \u00d7 10\u22127 M for Cu2+ and 1.24 \u00d7 10\u22127 M for Fe3+ respectively. This dual-response fluorescent probe for Cu2+ and Fe3+ was distinguished by further reduction of the ascorbic acid. It is reported for the first time to use ascorbic acid to discriminate Cu2+ and Fe3+ by fluorescent probe technology. The recognizing mechanism of QLBM toward Cu2+ and Fe3+ has been investigated in detail by NMR, HR-MS and density functional theory (DFT) calculations. Moreover, further application of the sensor in fluorescence imaging was studied in HeLa cells due to the low cytotoxicity and good photophysical properties, suggesting that QLBM could be used as a fluorescent sensor for tracking Cu2+ and Fe3+ in cells. \u00a9 2016 Elsevier B.V.",
        "keywords": [
            "Aqueous medium",
            "Cell imaging",
            "DFT",
            "Fluorescence sensor",
            "Quinoline"
        ],
        "authors": [
            {
                "name": "Zhang Bibo",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            },
            {
                "name": "Liu Haiyang",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            },
            {
                "name": "Wu Fengxu",
                "org": "College of Chemistry, Central China Normal University, Wuhan, China"
            },
            {
                "name": "Hao Gefei",
                "org": "College of Chemistry, Central China Normal University, Wuhan, China"
            },
            {
                "name": "Chen Yuzong",
                "org": "Shenzhen Technology and Engineering Laboratory for Personalized Cancer Diagnostics and Therapeutics, Shenzhen Kivita Innovative Drug Discovery Institute, Shenzhen, Guangdong, China"
            },
            {
                "name": "Tan Chunyan",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            },
            {
                "name": "Tan Ying",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            },
            {
                "name": "Jiang Yuyang",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            }
        ],
        "venue": "Sensors and Actuators, B: Chemical",
        "year": 2017
    },
    "CSeBsi3T": {
        "id": "CSeBsi3T",
        "title": "Core-shell assay based aptasensor for sensitive and selective thrombin detection using dark-field microscopy",
        "abstract": "In this work, we developed a robust and ultrasensitive bio-sensor based on the target-aptamer recognition strategy and microscopic enumeration of gold nanoparticles (AuNPs) using dark field microscopy (DFM). The aptasensor with a core-shell structure consisting of a magnetic bead (MB), aptamer and AuNPs was fabricated by complementary hybridization of the DNA probe on the AuNPs surface to the aptamer coupled to the MB. Upon addition of the target molecule, the strong interaction between the aptamer and the target molecule, thrombin, results in the release of the AuNPs from the MB. The quantities of thrombin is therefore linearly correlated to the number of the released AuNPs, which can be digitally counted using DFM. To demonstrate the feasible use of the aptasensor for target detection, thrombin was evaluated as the model target. The limit of detection was determined to be 2.54 fM with dynamic range of 6 fM\u2013100 fM. When the concentration of thrombin exceeded 100 fM, the counted number of AuNPs didn't correlate linearly to molecules of thrombin anymore, as the nanoparticles aggregated partly due to high concentration. However, the color of the solution changes to purple and the concentration of free AuNPs can be conveniently quantified by UV\u2013Vis spectroscopy for up to 100 nM. It is noteworthy that our aptasensor is very easy to operate and requires neither complex isolation and amplification processes nor expensive instruments and consumables. Furthermore, this strategy can be easily generalized to other targets by replacing the corresponding aptamers and show great potential for the detection of biomarkers in clinical samples. \u00a9 2018 Elsevier B.V.",
        "keywords": [
            "Aptasensor",
            "AuNPs",
            "DFM",
            "Thrombin"
        ],
        "authors": [
            {
                "name": "Yang Rui",
                "org": "Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Liu Shuwen",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, State Key Laboratory of Chemical Oncogenomics, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Wu Zhenjie",
                "org": "Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China, Department of Physics, Tsinghua University, Beijing, China"
            },
            {
                "name": "Tan Ying",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, State Key Laboratory of Chemical Oncogenomics, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Sun Shuqing",
                "org": "Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China, Department of Physics, Tsinghua University, Beijing, China"
            }
        ],
        "venue": "Talanta",
        "year": 2018
    },
    "Nlrnrv3B": {
        "id": "Nlrnrv3B",
        "title": "Sensitive and selective immunofluorescence assay for CA15-3 detection using fluorescein derivative A10254.",
        "abstract": "The determination of carbohydrate antigen 15-3 (CA15-3), a highly important specific cancer biomarker, in serum is essential for early diagnosis and detection of breast cancer. Herein, a sensitive immunofluorescence assay for CA15-3 detection in serum was developed using the antibody-antigen-antibody sandwich format. A10254, a fluorescein derivative, was used to label the CA15-3 antibody to enhance the assay sensitivity. The obtained fluorescence immunosensor could detect CA15-3 with high sensitivity and favorable specificity. The limits of detection (LOD) were determined to be 0.11 and 0.18 U mL-1 in a linear range of 0.25-14 U mL-1 in a buffer solution and 2% serum system, respectively. Moreover, the strong anti-interference ability and good reproducibility in 2% serum suggest that the IFA has great potential for the diagnosis of breast cancer in clinical practice.",
        "keywords": [
            "CA15-3 detection",
            "Immunofluorescence assay",
            "breast cancer.",
            "sandwich format",
            "sensitivity",
            "specificity"
        ],
        "authors": [
            {
                "name": "Xiaoting Huang",
                "org": "Tsinghua University - Department of Chemistry Beijing, China the Graduate School at Shenzhen, Tsinghua University - State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology Beijing. China."
            },
            {
                "name": "Haiyang Liu",
                "org": "Tsinghua University - Department of Chemistry Beijing, China the Graduate School at Shenzhen, Tsinghua University - State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology Beijing. China."
            },
            {
                "name": "Wei Fang",
                "org": "Tsinghua University - Chemistry Beijing, China the Graduate School at Shenzhen, Tsinghua University - State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology Shenzhen. China."
            },
            {
                "name": "Yan Lin",
                "org": "Department of Pharmacy Nanchang. China."
            },
            {
                "name": "Ying Tan",
                "org": "Tsinghua University - Department of Chemistry Beijing, China the Graduate School at Shenzhen, Tsinghua University - State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology Shenzhen. China."
            }
        ],
        "venue": "Protein and peptide letters",
        "year": 2018
    },
    "WmXhLRJG": {
        "id": "WmXhLRJG",
        "title": "A simple and novel amide ligand based on quinoline derivative used for palladium-catalyzed Suzuki coupling reaction",
        "abstract": "This paper discusses the synthesis of the amide ligand N,N-diisopropyl quinoline-2-carboxamide from quinoline-2-carboxylic acid and diisopropylamine. The prepared ligand was utilized in the palladium catalyzed Suzuki cross-coupling reaction in ethanol-water 1: 1 (v/v). The reaction exhibited high catalytic efficiency with low Pd loading (0.05 mol %) under mild reaction conditions (at 60-90 degrees C under air atmosphere). In this study, the catalyst was successfully used in coupling reactions between various aryl halides with phenylboronic acid to obtain desired products in excellent yields. Spectrometric methods of H-1 NMR, C-13 NMR, and HR-MS were used to characterize this amide ligand, and its binding properties toward the Pd center were also investigated in detail via HR-MS measurements. (C) 2015 Elsevier B.V. All rights reserved.",
        "keywords": [
            "MIYAURA REACTION",
            "ARYL CHLORIDES",
            "AEROBIC CONDITIONS",
            "ARYLBORONIC ACIDS",
            "EFFICIENT LIGAND",
            "TRIAZOLE LIGAND",
            "COMPLEXES",
            "WATER",
            "HECK",
            "CONVENIENT"
        ],
        "authors": [
            {
                "name": "Liu Haiyang",
                "org": ""
            },
            {
                "name": "Li Xiaoshuang",
                "org": ""
            },
            {
                "name": "Liu Feng",
                "org": ""
            },
            {
                "name": "Tan Ying",
                "org": ""
            },
            {
                "name": "Jiang Yuyang",
                "org": ""
            }
        ],
        "venue": "JOURNAL OF ORGANOMETALLIC CHEMISTRY",
        "year": 2015
    },
    "Jme0KTRC": {
        "id": "Jme0KTRC",
        "title": "A novel aptasensor strategy for protein detection based on G-quadruplex and exonuclease III-aided recycling amplification",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Huan Shi",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China"
            },
            {
                "name": "Tian Jin",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China"
            },
            {
                "name": "Jiewen Zhang",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China"
            },
            {
                "name": "Xiaoting Huang",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China"
            },
            {
                "name": "Chunyan Tan",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China"
            },
            {
                "name": "Yuyang Jiang",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China"
            },
            {
                "name": "Ying Tan",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China"
            }
        ],
        "venue": "Chinese Chemical Letters",
        "year": 2019
    },
    "3oYqSCco": {
        "id": "3oYqSCco",
        "title": "A sensitive colorimetric aptasensor based on trivalent peroxidase-mimic DNAzyme and magnetic nanoparticles",
        "abstract": "In this study, a novel colorimetric aptasensor was prepared by coupling trivalent peroxidase-mimic DNAzyme and magnetic nanoparticles for highly sensitive and selective detection of target proteins. A three G-quadruplex (G4) DNA-hemin complex was employed as the trivalent peroxidase-mimic DNAzyme, in which hemin assisted the G4-DNA to fold into a catalytic conformation and act as an enzyme. The design of the aptasensor includes magnetic nanoparticles (MNPs), complementary DNA (cDNA) modified with biotin, and a label-free single strand DNA (ssDNA) including the aptamer and trivalent peroxidase-mimic DNAzyme. The trivalent DNAzyme, which has the highest catalytic activity among multivalent DNAzymes, catalyzed the H2O2-mediated oxidation of ABTS. The colorless ABTS was oxidized to produce a blue-green product that can be clearly distinguished by the naked eye. The aptamer and trivalent peroxidase-mimic DNAzyme promote the specificity and sensitivity of this detection method, which can be generalized for other targets by simply replacing the corresponding aptamers. To demonstrate the feasible use of the aptasensor for target detection, a well-known tumor biomarker MUC1 was evaluated as the model target. The limits of detection were determined to be 5.08 and 5.60 nM in a linear range of 50\u20131000 nM in a buffer solution and 10% serum system, respectively. This colorimetric and label-free aptasensor with excellent sensitivity and strong anti-interference ability has potential application in disease diagnoses, prognosis tracking, and therapeutic evaluation. \u00a9 2018 Elsevier B.V.",
        "keywords": [
            "Aptasensor",
            "Colorimetric detection",
            "MUC1",
            "Magnetic nanoparticles",
            "Trivalent peroxidase-mimic DNAzyme"
        ],
        "authors": [
            {
                "name": "Liu Shuwen",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, State Key Laboratory of Chemical Oncogenomics, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            },
            {
                "name": "Xu Naihan",
                "org": "State Key Laboratory of Chemical Oncogenomics, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            },
            {
                "name": "Tan Chunyan",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, State Key Laboratory of Chemical Oncogenomics, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            },
            {
                "name": "Fang Wei",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, State Key Laboratory of Chemical Oncogenomics, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            },
            {
                "name": "Tan Ying",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, State Key Laboratory of Chemical Oncogenomics, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            },
            {
                "name": "Jiang Yuyang",
                "org": "State Key Laboratory of Chemical Oncogenomics, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China"
            }
        ],
        "venue": "Analytica Chimica Acta",
        "year": 2018
    },
    "beRQjS7S": {
        "id": "beRQjS7S",
        "title": "A fluorescent aptasensor with product-triggered amplification by exonuclease III digestion for highly sensitive ATP detection",
        "abstract": "Here we proposed a conceptually new amplified ATP assay by combination of exonuclease III (Exo III) with an allosteric aptasensor triggered by ATP with graphene oxide (GO) assistance. The assay needs only one single fluorophore-labelled DNA probe, which was designed having the fluorescence labelled nucleotide and enzymatic substrate sequence away from the ATP recognition aptamer sequence to avoid the hindrance of the target recognition and enzymatic cleavage. The signal amplification mechanism is based on the binding ability of the produced dAMP to the ATP aptamer. In every cycle, the ATP can trigger the assay probe to be digested by the Exo III. The digestion product includes 3 dAMPs, which also can trigger the assay probe. The limit of detection as low as 31 nM was achieved, which is very competitive compared to those of other aptasensors with a signal amplification strategy for ATP detection. We envision that this principle could facilitate the design and development of other aptamer-based ATP sensors using different nucleases and find their potential applications in biological and environmental fields in the future. \u00a9 2017 The Royal Society of Chemistry.",
        "keywords": [],
        "authors": [
            {
                "name": "He Shengnan",
                "org": "Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen Guangdong, China, Department of Pharmacology and Proteomics Center, Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II, Guangzhou, China"
            },
            {
                "name": "Qu Long",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, Ministry-Province Jointly Constructed Base, State Key Lab-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen Guangdong, China"
            },
            {
                "name": "Tan Ying",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, Ministry-Province Jointly Constructed Base, State Key Lab-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen Guangdong, China"
            },
            {
                "name": "Liu Feng",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, Ministry-Province Jointly Constructed Base, State Key Lab-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen Guangdong, China"
            },
            {
                "name": "Wang Yu",
                "org": "Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen Guangdong, China"
            },
            {
                "name": "Zhang Wei",
                "org": "Ministry-Province Jointly Constructed Base, State Key Lab-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen Guangdong, China"
            },
            {
                "name": "Cai Zhiming",
                "org": "Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen Guangdong, China"
            },
            {
                "name": "Mou Lisha",
                "org": "Shenzhen Xenotransplantation Medical Engineering Research and Development Center, Institute of Translational Medicine, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen Guangdong, China"
            },
            {
                "name": "Jiang Yuyang",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, Ministry-Province Jointly Constructed Base, State Key Lab-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen Guangdong, China"
            }
        ],
        "venue": "Analytical Methods",
        "year": 2017
    },
    "tKvwqVgd": {
        "id": "tKvwqVgd",
        "title": "Binding of a bcl-2 family inhibitor to bovine serum albumin: fluorescence quenching and molecular docking study.",
        "abstract": "Both fluorescence spectroscopic and molecular docking methods were used to investigate the interaction between bovine serum albumin (BSA) and a known Bcl-xl/Bcl-2 inhibitor HA 14-1. Based on the spectral overlap between the emission of BSA and absorption of HA 14-1, Forster energy transfer was proposed to be the possible quenching mechanism. The Stern-Volmer constants are 2.49 x 10\u2074, 2.04 x 10\u2074 and 0.90 x 10\u2074 M\u207b\u00b9 at 293, 303 and 318 K, respectively, indicating that a static quenching process dominates. Thermodynamic parameters were further obtained. The derived negative \u0394 H (-27.51 kJ mol\u207b\u00b9) and \u0394 S (-11.11 J mol\u207b\u00b9 K\u207b\u00b9) values suggest hydrogen bond interaction and van der Waals force are the main binding force. The docking study was performed on BSA model. According to the docking score and the number of hydrogen bonds, the potential binding site for HA 14-1 is proposed to be the site IIA, also known as drug site 1.",
        "keywords": [
            "STERN-VOLMER PLOTS",
            "SPECTROSCOPIC METHODS",
            "FATTY-ACIDS",
            "ASSOCIATION",
            "PROTEIN",
            "APOPTOSIS",
            "ANILINE",
            "REVEALS",
            "SITES",
            "BSA"
        ],
        "authors": [
            {
                "name": "Rui Zhao",
                "org": ""
            },
            {
                "name": "Yonghua Xie",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Chunyan Tan",
                "org": ""
            },
            {
                "name": "Yuyang Jiang",
                "org": ""
            }
        ],
        "venue": "Protein and peptide letters",
        "year": 2012
    },
    "RpuD7eTp": {
        "id": "RpuD7eTp",
        "title": "A novel near-infrared fluorescent hydrogen sulfide probe for live cell and tissue imaging",
        "abstract": "A dicyanoisophorone-based near-infrared fluorescent probe (NIR-NP) was successfully designed for hydrogen sulfide (H2S) detection. 7-Nitro-1,2,3-benzoxadiazole (NBD) amine, an electron-withdrawing group, was applied to quench the fluorescence of dicyanoisophorone-based fluorescent dyes and could be removed by H2S-specific thiolysis of an NBD amine bond, leading to a significant fluorescence turn-on response. The probe could quantitatively detect H2S with a lower detection limit (0.03 \u03bcM) in vitro and in living cells. The probe with a large Stokes shift (186 nm) showed a high selectivity to H2S in the presence of other biothiols, including glutathione, homocysteine, and cysteine. Moreover, the probe was successfully applied to image endogenous H2S in different tumor cells and in liver tissues. The excellent properties of the probe and its applications in cell and tissue imaging indicated its potential for further exploration and application of H2S in the pathophysiology of cancers and even in the diagnosis of H2S-related diseases.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaoting Huang",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University,Shenzhen 518055,P. R. China"
            },
            {
                "name": "Haiyang Liu",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University,Shenzhen 518060,P. R. China"
            },
            {
                "name": "Jiewen Zhang",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University,Shenzhen 518055,P. R. China"
            },
            {
                "name": "Boren Xiao",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University,Shenzhen 518055,P. R. China"
            },
            {
                "name": "Fengxu Wu",
                "org": "College of Chemistry, Central China Normal University,Wuhan,P. R. China"
            },
            {
                "name": "Yueying Zhang",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University,Shenzhen 518055,P. R. China"
            },
            {
                "name": "Ying Tan",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University,Shenzhen 518055,P. R. China"
            },
            {
                "name": "Yuyang Jiang",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University,Shenzhen 518055,P. R. China"
            },
            {
                "name": "Yuyang Jiang",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University,Shenzhen 518055,P. R. China"
            }
        ],
        "venue": "New Journal of Chemistry",
        "year": 2019
    },
    "GgCWdL3t": {
        "id": "GgCWdL3t",
        "title": "A one-step synthesized acridine-based fluorescent chemosensor for selective detection of copper(II) ions and living cell imaging",
        "abstract": "Herein, the easily approachable N,N\u2032-(acridine-3,6-diyl)dipicolinamide (ACC) prepared by only one step was evaluated as an efficient and selective chemosensor for the selective detection of copper ions (Cu2+). The fluorescence sensing behavior of ACC toward metal cations was investigated in an HEPES buffer aqueous solution. The fluorescence emission was significantly quenched in the presence of Cu2+ cations, whereas other metal cations showed a low interference. The limit of detection was found to be 1.2 \u00d7 10-7 M. The recognizing mechanism of ACC towards Cu2+ has been investigated by 1H NMR, HR-MS analysis, and density functional theory (DFT) calculations. Moreover, this sensor was verified to have low cytotoxicity and good imaging characteristics for Cu2+ in living cells; this suggested that ACC was a potential probe for the detection of Cu2+in vivo. \u00a9 2018 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.",
        "keywords": [],
        "authors": [
            {
                "name": "Dai Qiuzi",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, Ministry-Province Jointly Constructed Base for State Key Lab, Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            },
            {
                "name": "Liu Haiyang",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, Ministry-Province Jointly Constructed Base for State Key Lab, Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China, Key Laboratory of Optoelectronic Devices and Systems, Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, China"
            },
            {
                "name": "Gao Chunmei",
                "org": "Ministry-Province Jointly Constructed Base for State Key Lab, Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China, College of Chemistry and Chemical Engineering, Shenzhen University, Shenzhen, China"
            },
            {
                "name": "Li Wenlu",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, Ministry-Province Jointly Constructed Base for State Key Lab, Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            },
            {
                "name": "Zhu Caizhen",
                "org": "School of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, China"
            },
            {
                "name": "Lin Chengdong",
                "org": "School of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, China"
            },
            {
                "name": "Tan Ying",
                "org": "Ministry-Province Jointly Constructed Base for State Key Lab, Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            },
            {
                "name": "Yuan Zigao",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, Ministry-Province Jointly Constructed Base for State Key Lab, Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            },
            {
                "name": "Jiang Yuyang",
                "org": "Ministry-Province Jointly Constructed Base for State Key Lab, Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, China"
            }
        ],
        "venue": "New Journal of Chemistry",
        "year": 2018
    },
    "QiMfUTQQ": {
        "id": "QiMfUTQQ",
        "title": "Multitarget inhibitors derived from crosstalk mechanism involving VEGFR2.",
        "abstract": "Seven VEGFR small-molecule inhibitors have been approved by the US FDA as anticancer drugs, which confirms the therapeutic value of angiogenesis inhibitors. However, much more evidence indicates that VEGFR inhibition alone is usually not sufficient to block the tumor progress. The potential of some agents targeting VEGFR owes partially to the simultaneous inhibition of additional targets in other signaling pathways. In this review, the crosstalk between VEGFR2 and the additional targets in other signaling pathways, such as EGFR, MET, FGFR, PDGFR, c-Kit, Raf, PI3K and HDAC, and the synergistic effects derived from multitarget activities against these crosstalks are discussed. We also briefly describe the multitarget inhibitors in clinical trials or reported in the literature and patents under the different multitarget categories involving VEGFR2.",
        "keywords": [
            "ENDOTHELIAL GROWTH-FACTOR",
            "RENAL-CELL CARCINOMA",
            "TYROSINE KINASE INHIBITOR",
            "ADVANCED HEPATOCELLULAR-CARCINOMA",
            "PHASE-III TRIAL",
            "MEDULLARY-THYROID CANCER",
            "PANCREATIC NEUROENDOCRINE TUMORS",
            "HISTONE DEACETYLASE INHIBITORS",
            "MUTANT LUNG-CANCER",
            "RANDOMIZED DISCONTINUATION TRIAL"
        ],
        "authors": [
            {
                "name": "Chao Ding",
                "org": ""
            },
            {
                "name": "Cunlong Zhang",
                "org": ""
            },
            {
                "name": "Mingli Zhang",
                "org": ""
            },
            {
                "name": "Yu Zong Chen",
                "org": ""
            },
            {
                "name": "Chunyan Tan",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Yuyang Jiang",
                "org": ""
            }
        ],
        "venue": "Future medicinal chemistry",
        "year": 2014
    },
    "WpLqdlGO": {
        "id": "WpLqdlGO",
        "title": "Continuous and sensitive acid phosphatase assay based on a conjugated polyelectrolyte.",
        "abstract": "We report a novel continuous and sensitive fluorescence turn-on assay for ACPs, which consists of a cationic conjugated polyelectrolyte (PPE4+) and a commonly used phosphatase substrate p-nitrophenyl phosphate (pNPP). The kinetics of the ACP catalyzed hydrolysis of the substrate pNPP was monitored by the fluorescence change of PPE4+ and corresponding kinetic parameters were derived to be consistent with the literature reports. The applications of PPE4+/pNPP-based ACP assay in high-throughput screening of ACP inhibitors and detection of prostatic acid phosphotase (PAP) in vitro were demonstrated.",
        "keywords": [
            "PROTEIN PHOSPHATASE",
            "PROSTATE-CANCER",
            "PURIFICATION",
            "POLYMERS",
            "TARGET"
        ],
        "authors": [
            {
                "name": "Yonghua Xie",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Renxuan Liu",
                "org": ""
            },
            {
                "name": "Rui Zhao",
                "org": ""
            },
            {
                "name": "Chunyan Tan",
                "org": ""
            },
            {
                "name": "Yuyang Jiang",
                "org": ""
            }
        ],
        "venue": "ACS applied materials & interfaces",
        "year": 2012
    },
    "kc8CEhgd": {
        "id": "kc8CEhgd",
        "title": "A simple quinoline-derived fluorescent sensor for the selective and sequential detection of copper(II) and sulfide ions and its application in living-cell imaging",
        "abstract": "A simple amide compound (QLBA), prepared from quinoline-2-carboxylic acid and 2-(1H-benzo[d]imidazol-2-yl)aniline, was synthesized and evaluated as an efficient fluorescence chemosensor for the selective recognition of copper ions (Cu2+). This sensor could detect Cu2+ in CH3OH/HEPPES buffer in a wide pH range (4.0-10.0), with obvious fluorescence quenching. The obtained QLBA-Cu2+ complex could be used as a new cascade sensor for detecting sulfide anions (S2-). The corresponding detection limits were found to be 2.2 x 10(-7) M for Cu2+ and 4.6 x 10(-7) M for S2-. The sensing mechanisms of QLBA toward Cu2+ were systematically investigated in detail by NMR, HR-MS analysis, and density functional theory (DFT) calculations. In addition, this sensor was verified to be of low cytotoxicity and to have good imaging characteristics for the detection of Cu2+ and further for the recognition of S2- in living cells, suggesting that QLBA was a useful tool for tracking Cu2+ and S2- ions in vivo.",
        "keywords": [],
        "authors": [
            {
                "name": "Liu Haiyang",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base, State Key Lab,Shenzhen Key Lab Chem Biol, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Wu Fengxu",
                "org": "Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China"
            },
            {
                "name": "Zhang Bibo",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base, State Key Lab,Shenzhen Key Lab Chem Biol, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Tan Chunyan",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base, State Key Lab,Shenzhen Key Lab Chem Biol, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Chen Yuzong",
                "org": "Shenzhen Kivita Innovat Drug Discovery Inst, Shenzhen Technol & Engn Lab Personalized Canc Dia, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Hao Gefei",
                "org": "Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China"
            },
            {
                "name": "Tan Ying",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base, State Key Lab,Shenzhen Key Lab Chem Biol, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Jiang Yuyang",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base, State Key Lab,Shenzhen Key Lab Chem Biol, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "",
                "org": ""
            }
        ],
        "venue": "RSC ADVANCES",
        "year": 2016
    },
    "PFmWZwVb": {
        "id": "PFmWZwVb",
        "title": "A new strategy involving the use of peptides and graphene oxide for fluorescence turn-on detection of proteins",
        "abstract": "The detection of proteins is of great biological significance as disease biomarkers in early diagnosis, prognosis tracking and therapeutic evaluation. Thus, we developed a simple, sensitive and universal protein-sensing platform based on peptide and graphene oxide (GO). The design consists of a fluorophore (TAMRA, TAM), a peptide containing eight arginines and peptide ligand that could recognize the target protein, and GO used as a quencher. To demonstrate the feasible use of the sensor for target detection, Bcl-xL was evaluated as the model target. The sensor was proved to be sensitive and applied for the detection of the target proteins in buffer, 2% serum and living cells. \u00a9 2018 by the authors. Licensee MDPI, Basel, Switzerland.",
        "keywords": [
            "GO",
            "ariginines",
            "peptide",
            "selectivity",
            "sensitivity"
        ],
        "authors": [
            {
                "name": "Shi Huan",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Zhang Bibo",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Liu Shuwen",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Tan Chunyan",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Tan Ying",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Jiang Yuyang",
                "org": "The State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, The Graduate School at Shenzhen, Tsinghua University, Shenzhen, China, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China"
            }
        ],
        "venue": "Sensors (Switzerland)",
        "year": 2018
    },
    "v2hEg9x4": {
        "id": "v2hEg9x4",
        "title": "Diazobenzene-containing conjugated polymers as dark quenchers.",
        "abstract": "The synthesis and photophysical characterization of new conjugated polymers (CPs) with alternating phenylethynylene and diazobenzene (azo-PPE) units were reported, which showed broadened absorption and no measurable fluorescence. Quenching studies showed that azo-PPEs displayed high efficiency over a wide wavelength range.",
        "keywords": [
            "MOLECULAR BEACONS",
            "PHOTOPHYSICS",
            "DNA",
            "POLYELECTROLYTES",
            "HYDROGENATION",
            "ETHYNYLENE)",
            "CELLS"
        ],
        "authors": [
            {
                "name": "Jiatao Wu",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Yonghua Xie",
                "org": ""
            },
            {
                "name": "Yi Wu",
                "org": ""
            },
            {
                "name": "Rui Zhao",
                "org": ""
            },
            {
                "name": "Yuyang Jiang",
                "org": ""
            },
            {
                "name": "Chunyan Tan",
                "org": ""
            }
        ],
        "venue": "Chemical communications (Cambridge, England)",
        "year": 2013
    },
    "K7tFE5WM": {
        "id": "K7tFE5WM",
        "title": "Conjugated polyelectrolytes with a label-free aptamer for specific protein photoinactivation",
        "abstract": "Chromophore-assisted light inactivation (CALI) is a significant technique to realize knockdown or loss-of-function of target protein molecules in a spatiotemporally regulated manner. Based on the advantages of CALI, we hybridized PPET3-N2, a well-studied cation conjugated polyelectrolyte (CP), with a label-free DNA containing aptamer via electronic and hydrophobic interactions to produce reactive oxygen species (ROS) under light irradiation, which resulted in specific inactivation of the protein of interest, thrombin. The aptamer introduced into the system formed a complex with thrombin, whereby the aptamer decreased the distance between the PPET3-N2/DNA hybrid and thrombin. This proposed strategy efficiently inactivated thrombin with good specificity and provides a novel and universal approach for controlled inactivation of biomolecules. \u00a9 2018 The Royal Society of Chemistry.",
        "keywords": [],
        "authors": [
            {
                "name": "Fang Wei",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Liu Shuwen",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Tan Chunyan",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Li Anqi",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Tan Ying",
                "org": "Department of Chemistry, Tsinghua University, Beijing, China, State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Jiang Yuyang",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, China"
            }
        ],
        "venue": "Analytical Methods",
        "year": 2018
    },
    "er9AijSx": {
        "id": "er9AijSx",
        "title": "Magnetic bead-gold nanoparticle hybrids probe based on optically countable gold nanoparticles with dark-field microscope for T4 polynucleotide kinase activity assay.",
        "abstract": "T4 polynucleotide kinase (T4 PNK) plays an essential role in DNA phosphorylation during the DNA repair process. Therefore, the sensitive, selective and convenient detection of T4 PNK activity is of great significance. In this work, we proposed a sensitive non-amplification strategy for the sensing of T4 PNK activity via dark field microscope (DFM) based on magnetic bead (MB)-gold nanoparticle (AuNP) hybrids probe, MB-dsDNA-AuNP (MDA). In the presence of T4 PNK, the 5'-OH termini of DNA are phosphorylated and cleaved into oligonucleotides by lambda exonuclease (\u03bbexo), resulting in the destruction of the MDA probe and the separation of AuNP from the MB. Through automatic counting of AuNPs from DFM images, T4 PNK activity can be quantitatively measured. This strategy revealed a limit of detection (LOD) as low as 0.0058 U/mL and exhibited a dynamic range from 0.01 to 1 U/mL. The strategy presents an excellent ability to discriminate T4 PNK from the other proteins and enzymes. Notably, this strategy was applied to screen the T4 PNK inhibitors and test the activity in cell lysates, showing great potential for the discovery of new anticancer drugs and other related research field.",
        "keywords": [
            "Dark field microscopy",
            "Gold nanoparticles",
            "Magnetic bead",
            "T4 PNK activity"
        ],
        "authors": [
            {
                "name": "Tian Jin",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, PR China; Department of Chemistry, Tsinghua University, Beijing, 100084, PR China."
            },
            {
                "name": "Jiewen Zhang",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, PR China."
            },
            {
                "name": "Yuanfang Zhao",
                "org": "Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, PR China."
            },
            {
                "name": "Xiaoting Huang",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, PR China; Department of Chemistry, Tsinghua University, Beijing, 100084, PR China."
            },
            {
                "name": "Chunyan Tan",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, PR China; Department of Chemistry, Tsinghua University, Beijing, 100084, PR China."
            },
            {
                "name": "Shuqing Sun",
                "org": "Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, PR China; Department of Biomedical Engineering, Tsinghua University, Beijing, 100084, PR China. Electronic address: sun.shuqing@sz.tsinghua.edu.cn."
            },
            {
                "name": "Ying Tan",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, PR China; Department of Chemistry, Tsinghua University, Beijing, 100084, PR China. Electronic address: tan.ying@sz.tsinghua.edu.cn."
            }
        ],
        "venue": "Biosensors & bioelectronics",
        "year": 2019
    },
    "zopZFcgm": {
        "id": "zopZFcgm",
        "title": "Modulating aggregation-induced emission via a non-conjugated linkage of fluorophores to tetraphenylethenes",
        "abstract": "A fluorophore consisting of two fluorescent moieties could display unusual optical behaviors that are unattainable in a single-fluorophore compound. Herein we reported two \"dual-fluorophore\" dyes: DNS-linked tetraphenylethene demonstrates bright aggregation-induced emission, while NBD-linked tetraphenylethene exhibits aggregation-caused quenching. Our results have important implications for engineering emission behaviors of molecular aggregates for practical applications.",
        "keywords": [],
        "authors": [
            {
                "name": "Han Xie",
                "org": "Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China. yinj@mail.ccnu.edu.cn."
            },
            {
                "name": "Zhang Bibo",
                "org": "Ministry-Province Jointly Constructed Base, State Key Lab-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            },
            {
                "name": "Chen Jianhua",
                "org": "Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China"
            },
            {
                "name": "Liu Sheng Hua",
                "org": "Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China"
            },
            {
                "name": "Tan Chunyan",
                "org": "Ministry-Province Jointly Constructed Base, State Key Lab-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            },
            {
                "name": "Liu Haiyang",
                "org": "Ministry-Province Jointly Constructed Base, State Key Lab-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            },
            {
                "name": "Lang Matthew J.",
                "org": "Singapore-MIT Alliance for Research and Technology (SMART), 1 CREATE Way, Singapore, Singapore, Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, United States"
            },
            {
                "name": "Tan Ying",
                "org": "Ministry-Province Jointly Constructed Base, State Key Lab-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            },
            {
                "name": "Liu Xiaogang",
                "org": "Singapore-MIT Alliance for Research and Technology (SMART), 1 CREATE Way, Singapore, Singapore, Singapore University of Technology and Design, 8 Somapah Road, Singapore, Singapore"
            },
            {
                "name": "Yin Jun",
                "org": "Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China, Ministry-Province Jointly Constructed Base, State Key Lab-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            }
        ],
        "venue": "Journal of materials chemistry. B",
        "year": 2017
    },
    "9UfeqqG0": {
        "id": "9UfeqqG0",
        "title": "Protrusion-localized STAT3 mRNA promotes metastasis of highly metastatic hepatocellular carcinoma cells in vitro",
        "abstract": "Aim: Recent evidence shows that localization of mRNAs and their protein products at cellular protrusions plays a decisive function in the metastasis of cancer cells. The aim of this study was to identify the variety of proteins encoded by protrusion-localized mRNAs and their roles in the metastasis and invasion of liver cancer cells. Methods: Highly metastatic hepatocellular carcinoma cell line HCCLM3 and non-metastatic hepatocellular carcinoma cell line SMMC-7721 were examined. Cell protrusions (Ps) were separated from cell bodies (CB) using a Boyden chamber assay; total mRNA population in CB and Ps fractions was analyzed using high-throughput direct RNA sequencing. The localization of STAT3 mRNA and protein at Ps was confirmed using RT-qPCR, RNA FISH, and immunofluorescence assays. Cell migration capacity and invasiveness of HCCLM3 cells were evaluated using MIT, wound healing migration and in vitro invasion assays. The interaction between Stat3 and growth factor receptors was explored with co-immunoprecipitation assays. Results: In HCCLM3 cells, 793 mRNAs were identified as being localized in the Ps fraction according to a cut-off value (Ps/CB ratio) >1.6. The Ps-localized mRNAs could be divided into 4 functional groups, and were all closely related to the invasive and metastatic properties. STAT3 mRNA accumulated in the Ps of HCCLM3 cells compared with non-metastatic SMMC-7721 cells. Treatment of HCCLM3 cells with siRNAs against STAT3 mRNA drastically decreased the cell migration and invasion. Moreover, Ps-localized Stat3 was found to interact with pseudopod-enriched platelet-derived growth factor receptor tyrosine kinase (PDGFRTK) in a growth factor dependent manner. Conclusion: This study reveals STAT3 mRNA localization at the Ps of metastatic hepatocellular carcinoma HCCLM3 cells by combining application of genome-wide and gene specific description and functional analysis.",
        "keywords": [
            "hepatocellular carcinoma",
            "metastasis",
            "mRNA localization",
            "STAT3",
            "platelet-derived growth factor receptor",
            "HCCLM3 cells",
            "SMMC-7721 cells",
            "Boyden chamber assay"
        ],
        "authors": [
            {
                "name": "Liu Yan-hong",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China; Wenzhou Med Univ, Sch Lab Med & Life Sci, Zhejiang Prov Key Lab Med Genet, Key Lab Lab Med,Minist Educ China, Wenzhou 325035, Peoples R China"
            },
            {
                "name": "Jin Jia-lu",
                "org": "Hebi Polytech, Hebi 458030, Peoples R China"
            },
            {
                "name": "Wang Yu-zhe",
                "org": "Wenzhou Med Univ, Sch Lab Med & Life Sci, Zhejiang Prov Key Lab Med Genet, Key Lab Lab Med,Minist Educ China, Wenzhou 325035, Peoples R China"
            },
            {
                "name": "Tan Ying",
                "org": "Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Zhou Ying-ying",
                "org": "Wenzhou Med Univ, Sch Lab Med & Life Sci, Zhejiang Prov Key Lab Med Genet, Key Lab Lab Med,Minist Educ China, Wenzhou 325035, Peoples R China"
            },
            {
                "name": "Peng Ting",
                "org": "Wenzhou Med Univ, Sch Lab Med & Life Sci, Zhejiang Prov Key Lab Med Genet, Key Lab Lab Med,Minist Educ China, Wenzhou 325035, Peoples R China"
            },
            {
                "name": "Li Feng",
                "org": "Wenzhou Med Univ, Sch Lab Med & Life Sci, Zhejiang Prov Key Lab Med Genet, Key Lab Lab Med,Minist Educ China, Wenzhou 325035, Peoples R China"
            },
            {
                "name": "Liang Wan-dong",
                "org": "Wenzhou Med Univ, Sch Lab Med & Life Sci, Zhejiang Prov Key Lab Med Genet, Key Lab Lab Med,Minist Educ China, Wenzhou 325035, Peoples R China"
            },
            {
                "name": "Chartrand Pascal",
                "org": "Univ Montreal, Dept Biochem & Mol Med, Montreal, PQ H3C 3J7, Canada"
            },
            {
                "name": "Jiang Yu-yang",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base State Key La, Shenzhen 518055, Peoples R China; Tsinghua Univ, Sch Med, Dept Pharmacol & Pharmaceut Sci, Beijing 100084, Peoples R China"
            },
            {
                "name": "Shen Zhi-fa",
                "org": "Shenzhen Kivita Innovat Drug Discovery Inst, Shenzhen Technol & Engn Personalized Canc Diagnos, Shenzhen 518055, Peoples R China; Wenzhou Med Univ, Sch Lab Med & Life Sci, Zhejiang Prov Key Lab Med Genet, Key Lab Lab Med,Minist Educ China, Wenzhou 325035, Peoples R China"
            }
        ],
        "venue": "ACTA PHARMACOLOGICA SINICA",
        "year": 2016
    },
    "MDP7QuRI": {
        "id": "MDP7QuRI",
        "title": "Continuous and Sensitive Acid Phosphatase Assay Based on a Conjugated Polyelectrolyte",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ying tan",
                "org": ""
            },
            {
                "name": "yonghua xie",
                "org": ""
            },
            {
                "name": "yuyang jiang",
                "org": ""
            },
            {
                "name": "chunyan tan",
                "org": ""
            },
            {
                "name": "rui zhao",
                "org": ""
            },
            {
                "name": "renxuan liu",
                "org": ""
            }
        ],
        "venue": "ACS Applied Materials & Interfaces",
        "year": 2012
    },
    "jEIr0Z2C": {
        "id": "jEIr0Z2C",
        "title": "An aptasensor based on the microscopic enumeration of encoding gold nanoparticles for the detection of C-reactive protein",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yuanfang Zhao",
                "org": "Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen, P. R. China"
            },
            {
                "name": "Jingru Zhao",
                "org": "Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen, P. R. China"
            },
            {
                "name": "Tian Jin",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, P. R. China"
            },
            {
                "name": "Shuqing Sun",
                "org": "Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Graduate School at Shenzhen, Tsinghua University, Shenzhen, P. R. China"
            },
            {
                "name": "Wenlan Liu",
                "org": "The Central Laboratory, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen 518035, China"
            },
            {
                "name": "Ying Tan",
                "org": "State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, P. R. China"
            }
        ],
        "venue": "RSC Advances",
        "year": 2019
    },
    "IkySZoHE": {
        "id": "IkySZoHE",
        "title": "Mutation of the conserved GRG motif and decreasing activity of human RNase H2",
        "abstract": "RNase H2 consists of three subunits (H2A, H2B and H2C) and is involved in the hydrolysis of RNA/DNA hybrids. The GRG motif in RNase H2 is highly conserved and recognizes the ribonucleotides misincorporated into dsDNA. The mutant G37S in the GRG motif of human RNase H2A was found to be correlated with Aicardi-Goutisressyndrome (AGS). In this study, 4 mutants (G37S, G37A, R38A and G39A) were prepared and their biochemical properties of secondary structure, activity and binding affinity with substrate were studied in order to explore the function of the GRG motif. The activity assay showed that the mutations resulted in significantly decreased RNase activity. The binding efficiency assay demonstrated that binding affinities between 4 mutants and 1-ribo FAM-labeled substrate were significantly weakened. These results all indicated that the GRG motif contributes directly to substrate binding and is closely related to the enzyme activity.",
        "keywords": [
            "AICARDI-GOUTIERES-SYNDROME",
            "SUBSTRATE-SPECIFICITY",
            "RIBONUCLEASE-H",
            "CRYSTAL-STRUCTURES",
            "COMPLEX",
            "HII",
            "DNA",
            "PEPTIDES",
            "PROTEINS",
            "RESIDUES"
        ],
        "authors": [
            {
                "name": "Li Lin",
                "org": ""
            },
            {
                "name": "Shen Wanxiang",
                "org": ""
            },
            {
                "name": "Zheng Jing",
                "org": ""
            },
            {
                "name": "Lai Raofang",
                "org": ""
            },
            {
                "name": "Tan Chunyan",
                "org": ""
            },
            {
                "name": "Tan Ying",
                "org": ""
            },
            {
                "name": "Jiang Yuyang",
                "org": ""
            }
        ],
        "venue": "OPEN LIFE SCIENCES",
        "year": 2015
    },
    "WjSxLmZH": {
        "id": "WjSxLmZH",
        "title": "NPASS: Natural product activity and species source database for natural product research, discovery and tool development",
        "abstract": "There has been renewed interests in the exploration of natural products (NPs) for drug discovery, and continuous investigations of the therapeutic claims and mechanisms of traditional and herbal medicines. In-silico methods have been employed for facilitating these studies. These studies and the optimization of in-silico algorithms for NP applications can be facilitated by the quantitative activity and species source data of the NPs. A number of databases collectively provide the structural and other information of \u00e2 1/4470 000 NPs, including qualitative activity information for many NPs, but only \u00e2 1/44000 NPs are with the experimental activity values. There is a need for the activity and species source data of more NPs. We therefore developed a new database, NPASS (Natural Product Activity and Species Source) to complement other databases by providing the experimental activity values and species sources of 35 032 NPs from 25 041 species targeting 5863 targets (2946 proteins, 1352 microbial species and 1227 cell-lines). NPASS contains 446 552 quantitative activity records (e.g. IC50, Ki, EC50, GI50 or MIC mainly in units of nM) of 222 092 NP-target pairs and 288 002 NP-species pairs. NPASS, http://bidd2.nus.edu.sg/NPASS/, is freely accessible with its contents searchable by keywords, physicochemical property range, structural similarity, species and target search facilities. \u00a9 2017 The Author(s) .",
        "keywords": [],
        "authors": [
            {
                "name": "Zeng Xian",
                "org": "Breeding Base-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen Kivita Innovative Drug Discovery Institute, Shenzhen 518055, PR China."
            },
            {
                "name": "Zhang Peng",
                "org": "Bioinformatics and Drug Design group, Department of Pharmacy, National University of Singapore, Singapore 117543, Singapore."
            },
            {
                "name": "He Weidong",
                "org": "Bioinformatics and Drug Design group, Department of Pharmacy, National University of Singapore, Singapore 117543, Singapore."
            },
            {
                "name": "Qin Chu",
                "org": "Bioinformatics and Drug Design group, Department of Pharmacy, National University of Singapore, Singapore 117543, Singapore."
            },
            {
                "name": "Chen Shangying",
                "org": "Bioinformatics and Drug Design group, Department of Pharmacy, National University of Singapore, Singapore 117543, Singapore."
            },
            {
                "name": "Tao Lin",
                "org": "Bioinformatics and Drug Design group, Department of Pharmacy, National University of Singapore, Singapore 117543, Singapore."
            },
            {
                "name": "Wang Yali",
                "org": "Bioinformatics and Drug Design group, Department of Pharmacy, National University of Singapore, Singapore 117543, Singapore."
            },
            {
                "name": "Tan Ying",
                "org": "Breeding Base-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen Kivita Innovative Drug Discovery Institute, Shenzhen 518055, PR China."
            },
            {
                "name": "Gao Dan",
                "org": "Breeding Base-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen Kivita Innovative Drug Discovery Institute, Shenzhen 518055, PR China."
            },
            {
                "name": "Wang Bohua",
                "org": "Key Lab of Agricultural Products Processing and Quality Control of Nanchang City, Jiangxi Agricultural University, Nanchang 330045, PR China."
            },
            {
                "name": "Chen Zhe",
                "org": "Zhejiang Key Laboratory of Gastro-intestinal Pathophysiology, Zhejiang Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University, School of Medicine, Hangzhou Normal University, Hangzhou 310006, RP China."
            },
            {
                "name": "Chen Weiping",
                "org": "Key Lab of Agricultural Products Processing and Quality Control of Nanchang City, Jiangxi Agricultural University, Nanchang 330045, PR China."
            },
            {
                "name": "Jiang Yu Yang",
                "org": "Breeding Base-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen Kivita Innovative Drug Discovery Institute, Shenzhen 518055, PR China."
            },
            {
                "name": "Chen Yu Zong",
                "org": "Breeding Base-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen Kivita Innovative Drug Discovery Institute, Shenzhen 518055, PR China."
            },
            {
                "name": "",
                "org": ""
            }
        ],
        "venue": "Nucleic Acids Research",
        "year": 2018
    },
    "0YaW9tJO": {
        "id": "0YaW9tJO",
        "title": "A simple and sensitive aptasensor for colorimetric detection of adenosine triphosphate based on unmodified gold nanoparticles",
        "abstract": "A simple and sensitive colorimetric aptasensor for rapid and facile detection of adenosine triphosphate (ATP) has been demonstrated here based on aptamer-based hairpin probes and unmodified gold nanoparticles (AuNPs). The hairpin probe is constructed by adding another five nucleotides to the 5\u2032-end of an anti-ATP aptamer which can hybridize to nucleotides at the 3\u2032-end of the aptamer, forming a hairpin-shaped structure. In the absence of ATP, the hairpin probes are rigid, and the AuNPs are susceptible to salt-induced aggregation. Conversely, upon binding with target ATP, the hairpin probes undergo conformational changes, forming aptamer-ATP complexes and exposing flexible ends which coat the surface of AuNPs to inhibit their aggregation in the high salt solution. Subsequently, a blue-to-red color change can be recognized by the naked eye. The aptasensor achieved selective responses toward ATP with a detection limit of 0.1 \u03bcM, and exhibited high-quality detection performance in biological samples. In addition, this detection method is simple, rapid and cost-effective, holding great potential for further applications in point-of-care research. \u00a9 2017",
        "keywords": [
            "Aptamer",
            "Biosensor",
            "Colorimetric detection",
            "Gold nanoparticles"
        ],
        "authors": [
            {
                "name": "Mao Yu",
                "org": "Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China, The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Fan Tingting",
                "org": "The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Gysbers Rachel",
                "org": "Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St. W, Hamilton, ON, Canada"
            },
            {
                "name": "Tan Yin",
                "org": "The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Liu Feng",
                "org": "The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            },
            {
                "name": "Lin Shuo",
                "org": "Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China, Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, United States"
            },
            {
                "name": "Jiang Yuyang",
                "org": "The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, China"
            }
        ],
        "venue": "Talanta",
        "year": 2017
    },
    "TYFjaTTZ": {
        "id": "TYFjaTTZ",
        "title": "Database and Bioinformatics Studies of Probiotics",
        "abstract": "Probiotics have been widely explored for health benefits, animal cares, and agricultural applications. Recent advances in microbiome, microbiota, and microbial dark matter research have fueled greater interests in and paved ways for the study of the mechanisms of probiotics and the discovery of new probiotics from uncharacterized microbial sources. A probiotics database named PROBIO was developed to facilitate these efforts and the need for the information on the known probiotics, which provides the comprehensive information about the probiotic functions of 448 marketed, 167 clinical trial/field trial, and 382 research probiotics for use or being studied for use in humans, animals, and plants. The potential applications of the probiotics data are illustrated by several literature-reported investigations, which have used the relevant information for probing the function and mechanism of the probiotics and for discovering new probiotics. PROBIO can be accessed free of charge at http://bidd2.nus.edu.sg/probio/homepage.htm. \u00a9 2017 American Chemical Society.",
        "keywords": [
            "bacteria",
            "lineages",
            "mechanism",
            "microbiota",
            "probiotics"
        ],
        "authors": [
            {
                "name": "Tao Lin",
                "org": "School of Medicine, Hangzhou Normal University, Hangzhou, China"
            },
            {
                "name": "Wang Bohua",
                "org": "College of Life and Environmental Sciences, Collaborative Innovation Center for Efficient and Health Production of Fisheries in Hunan Province, Hunan University of Arts and Science, Changde, Hunan, China, Key Lab of Agricultural Products Processing and Quality Control of Nanchang City, Jiangxi Agricultural University, Nanchang, China"
            },
            {
                "name": "Zhong Yafen",
                "org": "Key Lab of Agricultural Products Processing and Quality Control of Nanchang City, Jiangxi Agricultural University, Nanchang, China"
            },
            {
                "name": "Pow Siok Hoon",
                "org": "Bioinformatics and Drug Design Group, Department of Pharmacy, Center for Computational Science and Engineering, National University of Singapore, Singapore, Singapore"
            },
            {
                "name": "Zeng Xian",
                "org": "Bioinformatics and Drug Design Group, Department of Pharmacy, Center for Computational Science and Engineering, National University of Singapore, Singapore, Singapore"
            },
            {
                "name": "Qin Chu",
                "org": "Bioinformatics and Drug Design Group, Department of Pharmacy, Center for Computational Science and Engineering, National University of Singapore, Singapore, Singapore"
            },
            {
                "name": "Zhang Peng",
                "org": "Bioinformatics and Drug Design Group, Department of Pharmacy, Center for Computational Science and Engineering, National University of Singapore, Singapore, Singapore"
            },
            {
                "name": "Chen Shangying",
                "org": "Bioinformatics and Drug Design Group, Department of Pharmacy, Center for Computational Science and Engineering, National University of Singapore, Singapore, Singapore"
            },
            {
                "name": "He Weidong",
                "org": "Bioinformatics and Drug Design Group, Department of Pharmacy, Center for Computational Science and Engineering, National University of Singapore, Singapore, Singapore"
            },
            {
                "name": "Tan Ying",
                "org": "Key Laboratory of Chemical Biology, Guangdong Province, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            },
            {
                "name": "Liu Hongxia",
                "org": "Key Laboratory of Chemical Biology, Guangdong Province, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            },
            {
                "name": "Jiang Yuyang",
                "org": "Key Laboratory of Chemical Biology, Guangdong Province, Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, China"
            },
            {
                "name": "Chen Weiping",
                "org": "Key Lab of Agricultural Products Processing and Quality Control of Nanchang City, Jiangxi Agricultural University, Nanchang, China"
            },
            {
                "name": "Chen Yu Zong",
                "org": "Bioinformatics and Drug Design Group, Department of Pharmacy, Center for Computational Science and Engineering, National University of Singapore, Singapore, Singapore"
            }
        ],
        "venue": "Journal of Agricultural and Food Chemistry",
        "year": 2017
    },
    "uYlKiaeF": {
        "id": "uYlKiaeF",
        "title": "Label-free fluorescent assays based on aptamer-target recognition.",
        "abstract": "Label-free fluorescent assays were developed based on the competition of intramolecular DNA hybridization and aptamer-target binding. Using small molecule adenosine triphosphate (ATP) and biomacro-molecule thrombin as model targets, our design was proved to be a general method with good sensitivity and high selectivity.",
        "keywords": [
            "SWITCHING SIGNALING APTAMERS",
            "NUCLEIC-ACID APTAMERS",
            "IN-VITRO SELECTION",
            "ELECTROCHEMICAL DETECTION",
            "SENSORS",
            "THROMBIN",
            "LIGANDS",
            "COMPLEX",
            "PROBES",
            "DISPLACEMENT"
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Xin Zhang",
                "org": ""
            },
            {
                "name": "Yonghua Xie",
                "org": ""
            },
            {
                "name": "Rui Zhao",
                "org": ""
            },
            {
                "name": "Chunyan Tan",
                "org": ""
            },
            {
                "name": "Yuyang Jiang",
                "org": ""
            }
        ],
        "venue": "The Analyst",
        "year": 2012
    },
    "KVVBXppR": {
        "id": "KVVBXppR",
        "title": "An efficient quinoline-based fluorescence sensor for zinc(II) and its application in live-cell imaging",
        "abstract": "A novel and efficient quinoline-based fluorescent chemosensor (QLSA) for zinc(II) ion (Zn2+) detection was reported. This sensor was facilely synthesized via a simple linker NH2-NH2 connected quinoline-2-carboxylic acid and salicylaldehyde. This non-fluorescent quinoline derivative can detect Zn2+ with high sensitivity and favorable specificity and lead to significant fluorescence OFF-ON switching. The detection limit for Zn2+ was found to be 2.1 x 10(-8) M. The mechanism of the interaction between the sensor and Zn2+ has been investigated in detail through NMR and HRMS analysis. The sensor exhibited low cytotoxicity and larger Stokes shifts (171 nm) which are important and desired features for a fluorophore in live-cell imaging. Moreover, further application of the sensor in fluorescence imaging was studied in Hela cell by confocal fluorescence microscopy, suggesting that the sensor was proved to be a useful tool for tracking Zn2+ levels in vivo. (C) 2016 Elsevier B.V. All rights reserved.",
        "keywords": [
            "Fluorescence sensor",
            "Quinoline",
            "Zinc ion",
            "Cell imaging",
            "Stokes shift"
        ],
        "authors": [
            {
                "name": "Liu Haiyang",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base State Key La, Shenzhen Key Lab Chem Biol, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Dong Yunsheng",
                "org": "Tsinghua Univ, Grad Sch Shenzhen, Adv Mat Inst, Shenzhen 518055, Peoples R China"
            },
            {
                "name": "Zhang Bibo",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base State Key La, Shenzhen Key Lab Chem Biol, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Liu Feng",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base State Key La, Shenzhen Key Lab Chem Biol, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Tan Chunyan",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base State Key La, Shenzhen Key Lab Chem Biol, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Tan Ying",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base State Key La, Shenzhen Key Lab Chem Biol, Shenzhen 518055, Guangdong, Peoples R China"
            },
            {
                "name": "Jiang Yuyang",
                "org": "Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tsinghua Univ, Grad Sch Shenzhen, Minist Prov Jointly Constructed Base State Key La, Shenzhen Key Lab Chem Biol, Shenzhen 518055, Guangdong, Peoples R China; Tsinghua Univ, Sch Med, Dept Pharmacol & Pharmaceut Sci, Beijing 100084, Peoples R China"
            }
        ],
        "venue": "SENSORS AND ACTUATORS B-CHEMICAL",
        "year": 2016
    },
    "gTJNpUgf": {
        "id": "gTJNpUgf",
        "title": "New Nonlinear Filtering Algorithm Based on SVD",
        "abstract": "A derivative-free Kalman filter method based on the singular value decomposition (SVD) was proposed to improve numerical stability of unscented Kalman filter (UKF) algorithm. This method based on UKF framework used SVD technique to decompose the covariance matrix in the original method. The new method succeeds in avoiding the invalidation caused by errors during computation. It has excellent numerical stability without filtering precision degradation and computation complexity increase. A typical numerical example demonstrates the performance of the method. Simulation results demonstrate the validity of the proposed approach further.",
        "keywords": [
            "singular value decomposition",
            "numerical stability",
            "nonlinear filtering",
            "unscented Kalman filter"
        ],
        "authors": [
            {
                "name": "QU Cong-shan",
                "org": "The Second Artillery Engineering College, Xi\u2019an , China"
            },
            {
                "name": "XU Hua-long",
                "org": "The Second Artillery Engineering College, Xi\u2019an , China"
            },
            {
                "name": "TAN Ying",
                "org": "The Second Artillery Engineering College, Xi\u2019an , China"
            }
        ],
        "venue": "Journal of System Simulation",
        "year": 2009
    },
    "OVe7nUQw": {
        "id": "OVe7nUQw",
        "title": "Design of Missile Servo Mechanism Test System Based on PC/104 Bus",
        "abstract": "The missile servo mechanism test is one of the main topics of this paper.A servo mechanism test system with high reliability,high precision,small size based on PC/104 bus was presented,and hardware and software design of the system was described in detail.The general-purpose test system is featured with its transplantable and extendible test software.",
        "keywords": [
            "test system",
            "servo mechanism",
            "PC/104 bus"
        ],
        "authors": [
            {
                "name": "TAN Ying",
                "org": "The Second Artillery Engineering College,Xi'an ,China"
            },
            {
                "name": "XU Hualong",
                "org": "The Second Artillery Engineering College,Xi'an ,China"
            },
            {
                "name": "QU Congshan",
                "org": "The Second Artillery Engineering College,Xi'an ,China"
            }
        ],
        "venue": "Journal of Projectiles,Rockets,Missiles and Guidance",
        "year": 2008
    },
    "2cVyH2Mv": {
        "id": "2cVyH2Mv",
        "title": "Design of Actuator Test System Based on PC/104 Bus",
        "abstract": "The actuator test system is one of the key devices throughout the whole manufacturing line of missiles.Certain actuator test system with high credibility,high precision,which is used Virtual Instrument(VI) and based on PC/104 bus,has been built up.The main research content in the thesis is the soft-hardware design of the test system.The test system gives all kinds of control signals,measures the angles of the actuator and displays the results automatically,then the automation degree of actuator measuring is highly increased.",
        "keywords": [
            "test system",
            "PC/104 bus",
            "actuator",
            "virtual instrument"
        ],
        "authors": [
            {
                "name": "TAN Ying",
                "org": "The Second Artillery Engineering College,Xi'an ,China"
            },
            {
                "name": "XU Hua-long",
                "org": "The Second Artillery Engineering College,Xi'an ,China"
            },
            {
                "name": "QU Cong-shan",
                "org": "The Second Artillery Engineering College,Xi'an ,China"
            }
        ],
        "venue": "Journal of Projectiles,Rockets,Missiles and Guidance",
        "year": 2007
    },
    "bkDQAulJ": {
        "id": "bkDQAulJ",
        "title": "Design of High-accuracy Signal Source Based on PC/104 Bus",
        "abstract": "Design and development of a miniaturized,portable and intelligent signal source system with high accuracy,which is used virtual instrument and based on PC/104 bus,is presented in this thesis.The design philosophy is based on the mobility need of missile force and the feature of development of modern test instruments.Design of hardware and software of this system is introduced in detail.Test result shows that this signal source system can output different ranges of AC,DC voltage and DC current with required accuracy.",
        "keywords": [
            "PC/104 bus",
            "virtual instrument",
            "high accuracy",
            "signal source"
        ],
        "authors": [
            {
                "name": "TAN Ying",
                "org": "The Second Artillery Engineering College,Xi'an ,China"
            },
            {
                "name": "XU Hua-long",
                "org": "The Second Artillery Engineering College,Xi'an ,China"
            },
            {
                "name": "QU Cong-shan",
                "org": "The Second Artillery Engineering College,Xi'an ,China"
            }
        ],
        "venue": "Journal of Projectiles,Rockets,Missiles and Guidance",
        "year": 2007
    },
    "McXJheTl": {
        "id": "McXJheTl",
        "title": "Trend extraction from laser gyro drift data based on modified empirical mode decomposition",
        "abstract": "To improve the modeling accuracy of laser gyro and hence the precision of inertial navigation system, trend item extraction from laser gyro's drifting data was needed. Considering the nonlinearity and non-stationarity of laser gyro's drifting data, a modified EMD method based on adaptive sine extending to extract the trend item of Gyro's drifts was proposed. The proposed method added sine functions with proper phase, amplitude and frequency to the ends of the signal according to its tendency, so as to restrain end effects and improve the decomposition accuracy of normal EMD. Numerical simulation and practical application results indicated that the proposed method is efficacious with the merits of strong adaptability and high decomposition accuracy.",
        "keywords": [
            "Empirical mode decomposition",
            "Laser gyro",
            "Time series analysis",
            "Trend extraction"
        ],
        "authors": [
            {
                "name": "QU Cong-shan",
                "org": "Second Artillery Engineering College Xi An(Second Artillery Engineering College,The Second Artillery Engineering College,The Second Artillery Engineering Institute,Second Artillery Engineering Institute),Xi An,China"
            },
            {
                "name": "XU Hua-long",
                "org": "Second Artillery Engineering College Xi An(Second Artillery Engineering College,The Second Artillery Engineering College,The Second Artillery Engineering Institute,Second Artillery Engineering Institute),Xi An,China"
            },
            {
                "name": "Ying Tan",
                "org": "Second Artillery Engineering College Xi An(Second Artillery Engineering College,The Second Artillery Engineering College,The Second Artillery Engineering Institute,Second Artillery Engineering Institute),Xi An,China"
            },
            {
                "name": "XIA Ke-han",
                "org": "The Second Artillery Equipment Academy(Second Artillery Equipment Academy,The Second Artillery Equipment Academy),Beijing,China"
            }
        ],
        "venue": "Yuhang Xuebao/Journal of Astronautics",
        "year": 2009
    },
    "SM2wrGcX": {
        "id": "SM2wrGcX",
        "title": "Attitude determination method for near space vehicle based on adaptive sampling filters",
        "abstract": "To improve the accuracy and robustness of attitude estimation in near space vehicle, an online noise covariance adaptive estimation based unscented Kalman filtering(UKF) approach is proposed by taking advantage of the combination of adaptive estimation and nonlinear filtering. The developed approach is based on the limited memory method for the proper computation of the noises covariance. After having deduced the proposed algorithm theoretically in detail, the approach is tested in the INS/Star-sensor integrated attitude determination system. Test results show that the proposed method outperforms the standard UKF with higher accuracy and robustness, and it has high precision of attitude about 10 arcsecond, so it can meet the demand of near space vehicle's attitude determination.",
        "keywords": [
            "Attitude determination",
            "Near space vehicle",
            "Nonlinear filter",
            "Star sensor"
        ],
        "authors": [
            {
                "name": "QU Cong-shan",
                "org": "Second Artillery Engineering College Xi An(Second Artillery Engineering College,The Second Artillery Engineering College,The Second Artillery Engineering Institute,Second Artillery Engineering Institute),Xi An,China"
            },
            {
                "name": "XU Hua-long",
                "org": "Second Artillery Engineering College Xi An(Second Artillery Engineering College,The Second Artillery Engineering College,The Second Artillery Engineering Institute,Second Artillery Engineering Institute),Xi An,China"
            },
            {
                "name": "Ying Tan",
                "org": "Second Artillery Engineering College Xi An(Second Artillery Engineering College,The Second Artillery Engineering College,The Second Artillery Engineering Institute,Second Artillery Engineering Institute),Xi An,China"
            },
            {
                "name": "Min D. Song",
                "org": "Second Artillery Engineering College Xi An(Second Artillery Engineering College,The Second Artillery Engineering College,The Second Artillery Engineering Institute,Second Artillery Engineering Institute),Xi An,China"
            }
        ],
        "venue": "Yuhang Xuebao/Journal of Astronautics",
        "year": 2009
    },
    "uUrV7XMs": {
        "id": "uUrV7XMs",
        "title": "Algorithm for High Precision Horizontal Alignment of Ballistic Missile",
        "abstract": "To improve the shooting accuracy of the ballistic missile,a horizontal alignment algorithm that was suitable for the shake environment was put forward when the horizontal alignment error on precision of fire was considered in this paper.The computation model was given out.The simulation results showed that the horizontal alignment precision of the algorithm was high,which estimation error of angular misalignment was less than 1\u2032 under conditions that the swing was not more than 50\u2032 in 90 seconds,so it was better than the original alignment and was easy to be realized because of its little computation.",
        "keywords": [
            "Shake environment",
            "Horizontal alignment",
            "Estimation error",
            "Ballistic missile",
            "Initial alignment"
        ],
        "authors": [
            {
                "name": "QU Cong-shan",
                "org": "The Second Artillery Engineering College,Xi\u2032an Shaanxi ,China"
            },
            {
                "name": "TAN Ying",
                "org": "The Second Artillery Engineering College,Xi\u2032an Shaanxi ,China"
            },
            {
                "name": "XU Hua-long",
                "org": "The Second Artillery Engineering College,Xi\u2032an Shaanxi ,China"
            }
        ],
        "venue": "Aerospace Shanghai",
        "year": 2009
    },
    "cg8tdDzj": {
        "id": "cg8tdDzj",
        "title": "Random signal de-noising based on empirical mode decomposition for laser gyro",
        "abstract": "The various random noises in laser gyro are the main factors generating errors. In accordance with the special property of laser gyro\u2032 s noise,traditional filtering methods have many shortages to remove the noise. In order to restrain the random floating and improve the applicability precision for laser gyro, an improved de -noising algorithm based on the empirical mode decomposition (EMD) was proposed. The signal between the two adjacent zero crossing points within the intrinsic mode function (IMF) of EMD was defined as the modular cell by the method, which was treated as the basic analyzable object. Categories for the modular cell were judged by dealing with the amplitude of the cell, and then the filtering model was established. Evolutional rules of the amplitude for the modular cell were analyzed when the noisy signal corrupted by fractional Gaussian noise with different Hurst exponent were decomposed by EMD method, and threshold choosing rules used in Gaussian de -noising were also established. A signal de-noising test for laser gyro was performed to demonstrate the performance of the method. Compared with different de-nosing algorithms based on Allan variance method, the experimentalresults demonstrate the validity and superiority of the proposed algorithm.",
        "keywords": [
            "Adaptive filter",
            "Empirical mode decomposition",
            "Laser gyro",
            "Signal de-noising"
        ],
        "authors": [
            {
                "name": "QU Cong-shan",
                "org": " The Second Artillery Engineering College, Xi\u2032an , China"
            },
            {
                "name": "YU Hong",
                "org": " Shenyang Tianxiong Information Technology Developing Ltd., Shenyang , China"
            },
            {
                "name": "XU Hua-long",
                "org": " The Second Artillery Engineering College, Xi\u2032an , China"
            },
            {
                "name": "TAN Ying",
                "org": " The Second Artillery Engineering College, Xi\u2032an , China"
            }
        ],
        "venue": "Infrared and Laser Engineering",
        "year": 2009
    },
    "zQkwGwVe": {
        "id": "zQkwGwVe",
        "title": "A survey of nonlinear Bayesian filtering algorithms",
        "abstract": "The main goal of filtering is to obtain,recursively in time,optimal estimation and prediction of the dynamical systems and error statistics from the sequential observations.Various nonlinear filtering algorithms are reviewed and interpreted in a unified way using the recursive Bayesian estimation.According to different approximation methods,these approximate nonlinear filters can be categorized into three types:analytical approximations,deterministic-sampling based approaches,and stochastic-sampling based filters.Then the principles,methods and characteristics of above nonlinear filters are analyzed and reviewed in detail.Finally,some representative new developments of the nonlinear filtering are described,and further research prospects are introduced.",
        "keywords": [
            "differential filter",
            "nonlinear filtering",
            "particle filter",
            "unscented Kalman filter",
            "recursive Bayesian estimation"
        ],
        "authors": [
            {
                "name": "XU Hua-long",
                "org": "The Second Artillery Engineering College,Xi'an ,China"
            },
            {
                "name": "TAN Ying",
                "org": "The Second Artillery Engineering College,Xi'an ,China"
            }
        ],
        "venue": "Electronics Optics & Control",
        "year": 2008
    },
    "v49Dfp0x": {
        "id": "v49Dfp0x",
        "title": "Research on auto-collimation method and simulation for ballistic missile",
        "abstract": "A two-position auto-collimation method was proposed to shorten preparation time of launch for ballistic missile under a certain collimation precision. Different from traditional two-position locating method, the method doesn't need to know the latitude of launch position and the indexing-angle can be chose freely. The calculation formula of two-position collimation was deduced, main factors which influence the collimation precision were analyzed, a numeric simulation was carried out. Simulation results show that maximum azimuth error of collimation is less than 5\u2032, under conditions of system error of triple standard deviation and random error of 0.0005. The method can satisfy aiming requirement of the missile at the situations of utilizing integrated guidance system, lower initial collimation precision and higher requirement of fast maneuverability.",
        "keywords": [
            "control and navigation for flight vehicle",
            "auto-collimation",
            "ballistic missile",
            "simulation",
            "gyroscope"
        ],
        "authors": [
            {
                "name": "QU Cong-shan",
                "org": "The Second Artillery Engineering College,Xi'an ,Shaanxi,China"
            },
            {
                "name": "XIA Ke-han",
                "org": "The Second Artillery Equipment Academy,Bejing ,China"
            },
            {
                "name": "XU Hua-long",
                "org": "The Second Artillery Engineering College,Xi'an ,Shaanxi,China"
            },
            {
                "name": "TAN Ying",
                "org": "The Second Artillery Engineering College,Xi'an ,Shaanxi,China"
            }
        ],
        "venue": "Binggong Xuebao/Acta Armamentarii",
        "year": 2009
    },
    "fHnXppcS": {
        "id": "fHnXppcS",
        "title": "Arbitrary FIR Filter Synthesis Using a Neural Network",
        "abstract": "We propose a neural network to synthesizean arbitrary FIR filter in a least square sense.The network can evolve to itssteady-states or equilibrium points from any initialstate in the magnitude of the circuit\u2018s time constant.Under the steady-state, the output of the network isjust our designed FIR filter coefficient if a real,symmetric, and positive-definite matrix calculated bythe design specifications is directly used as thesynaptic strength matrix.",
        "keywords": [
            "neural network evolutionary optimization",
            "arbitrary FIR filter synthesis",
            "eigenproblem"
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": "Department of Electronic Engineering and Information Science, University of Science and Technology of China, P.R. China"
            },
            {
                "name": "Zhenya He",
                "org": "Department of Radio Engineering, Southeast University, P.R. China E-mail: ytan@ipc.ustc.edu.cn"
            }
        ],
        "venue": "Neural Processing Letters",
        "year": 1998
    },
    "uTcIfBy6": {
        "id": "uTcIfBy6",
        "title": "A unified framework for synthesis of cosine-modulated filter banks and corresponding wavelets",
        "abstract": "By directly optimizing the impulse response coefficient of filter banks, the synthesis of cosine-modulated FIR filter banks and cosine-modulated wavelets can be carried out in a unified framework. Through proper transformation, the problem is formulated as a quadratic-constrained least-squares (QCLS) minimization problem where all constraint matrices are symmetric and positive definite. Furthermore, we create an analog neural network by the augmented cost of the QCLS problem for designing filter banks and wavelets in real time. It turns out that the analysis and synthesis filters with high stopband attenuation and compactly supported wavelets are easily obtained by this method. Computer simulations illustrates the efficiency and effectiveness of our method.",
        "keywords": [
            "corresponding wavelet",
            "cosine-modulated wavelet",
            "augmented cost",
            "synthesis filter",
            "cosine-modulated fir filter bank",
            "unified framework",
            "constraint matrix",
            "analog neural network",
            "minimization problem",
            "qcls problem",
            "filter bank",
            "cosine-modulated filter bank",
            "computer simulation",
            "neural network",
            "fir filter",
            "impulse response",
            "positive definite",
            "real time"
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": "School of Information Science and Technology, University of Science and Technology of China, Hefei, China"
            }
        ],
        "venue": "ISNN (2)",
        "year": 2005
    },
    "8teBD3IX": {
        "id": "8teBD3IX",
        "title": "A Neural Network Approach for Signal Detection in Digital Communications",
        "abstract": "In this paper, we propose a new approach for signal detection in wireless digital communications based on the neural network with transient chaos and time-varying gain (NNTCTG), and give a concrete model of the signal detector after appropriate transformations and mappings. It is well known that the problem of the maximum likelihood signal detection can be described as a complex optimization problem that has so many local optima that conventional Hopfield-type neural networks fail to solve. By refraining from the serious local optima problem of Hopfield-type neural networks, the NNTCTG makes use of the time-varying parameters of the recurrent neural network to control the evolving behavior of the network so that the network undergoes the transition from chaotic behavior to gradient convergence. It has richer and more flexible dynamics rather than conventional neural networks only with point attractors, so that it can be expected to have much ability to search for globally optimal or near-optimal solutions. After going through a transiently inverse-bifurcation process, the NNTCTG can approach the global optimum or the neighborhood of global optimum of our problem. Simulation experiments have been performed to show the effectiveness and validation of the proposed neural network based method for the signal detection in digital communications.",
        "keywords": [
            "communications signal detection",
            "MLSE",
            "neural networks",
            "transient chaos",
            "real-time optimization"
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": "Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei, 230027, Peoples Republic of China"
            }
        ],
        "venue": "VLSI Signal Processing",
        "year": 2002
    },
    "OpSBkpre": {
        "id": "OpSBkpre",
        "title": "Algorithms of non-self detector by negative selection principle in artificial immune system",
        "abstract": "According to the principles of non-self detection and negative selection in natural immune system, two generating algorithms of detector are proposed in this paper after reviewing current detector generating algorithms used in artificial immune systems. We call them as Bit Mutation Growth Detector Generating Algorithm (BMGDGA) and Arithmetical-compliment Growth Detector Generating Algorithm (AGDGA) based on their operational features. The principle and work procedure of the two detector generating algorithms are elaborated in details in the paper. For evaluation of the proposed algorithms, they are tested and verified by using different datasets, and compared to Exhaustive Detector Generating Algorithm (EDGA). It turns out that the proposed two algorithms are superior to EDGA in detection performance and computational complexities.",
        "keywords": [
            "non-self detector",
            "bit mutation growth detector",
            "artificial immune system",
            "detector generating algorithm",
            "exhaustive detector generating algorithm",
            "current detector generating",
            "negative selection principle",
            "natural immune system",
            "proposed algorithm",
            "generating algorithm",
            "detection performance",
            "arithmetical-compliment growth detector generating",
            "immune system",
            "computational complexity",
            "generic algorithm",
            "negative selection"
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": "School of Information Science and Technology, University of Science and Technology of China, Hefei, P.R. China"
            },
            {
                "name": "Zhenhe Guo",
                "org": "School of Information Science and Technology, University of Science and Technology of China, Hefei, P.R. China"
            }
        ],
        "venue": "ICNC (2)",
        "year": 2005
    },
    "9OhdK67T": {
        "id": "9OhdK67T",
        "title": "An NN-Based Malicious Executables Detection Algorithm Based on Immune Principles",
        "abstract": "\n Detection of unknown malicious executables is one of most important tasks of Computer Immune System (CIS) studies. By using\n non-self detection, anomaly detection based on thickness, diversity of anti-body (Ab) and artificial neural networks, this\n paper proposes an NN-based malicious executables detection algorithm. This algorithm includes three parts, i.e., detector\n generation, anomaly information extraction and classification. At last, a number of experiments illustrate that this algorithm\n has high detection rate with very low the false positive rate.\n \n ",
        "keywords": [
            "information extraction",
            "immune system",
            "anomaly detection",
            "anti body",
            "false positive rate",
            "artificial neural network"
        ],
        "authors": [
            {
                "name": "Zhenhe Guo",
                "org": "Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei, 230027 China"
            },
            {
                "name": "Zhengkai Liu",
                "org": "Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei, 230027 China"
            },
            {
                "name": "Ying Tan",
                "org": "Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei, 230027 China"
            }
        ],
        "venue": "ISNN (2)",
        "year": 2004
    },
    "1xDsmhTe": {
        "id": "1xDsmhTe",
        "title": "Design method for cosine-modulated quadrature mirror filter bank",
        "abstract": "The design problem of cosine-modulated QMF banks satisfying the perfect-reconstruction property has been formulated as a quadratic-constrained least-squares (QCLS) optimization problem whose constrained matrices are symmetric and positive definite. In order to efficiently solve this kind of QCLS optimization problems, a cost function which is a convex function of our desired prototype filter coefficients is constructed. So a global minimum of this problem can be easily obtained. Results of two digital design examples are presented to support the derivatives and analyses.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Xiqi Gao",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Zhenya He",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            }
        ],
        "venue": "Tien Tzu Hsueh Pao/Acta Electronica Sinica",
        "year": 1999
    },
    "WzU5MeIq": {
        "id": "WzU5MeIq",
        "title": "Structural insight into human variegate porphyria disease.",
        "abstract": "Human protoporphyrinogen IX oxidase (hPPO), a mitochondrial inner membrane protein, converts protoporphyrinogen IX to protoporphyrin IX in the heme biosynthetic pathway. Mutations in the hPPO gene cause the inherited human disease variegate porphyria (VP). In this study, we report the crystal structure of hPPO in complex with the coenzyme flavin adenine dinucleotide (FAD) and the inhibitor acifluorfen at a resolution of 1.9 \u212b. The structural and biochemical analyses revealed the molecular details of FAD and acifluorfen binding to hPPO as well as the interactions of the substrate with hPPO. Structural analysis and gel chromatography indicated that hPPO is a monomer rather than a homodimer in vitro. The founder-effect mutation R59W in VP patients is most likely caused by a severe electrostatic hindrance in the hydrophilic binding pocket involving the bulky, hydrophobic indolyl ring of the tryptophan. Forty-seven VP-causing mutations were purified by chromatography and kinetically characterized in vitro. The effect of each mutation was demonstrated in the high-resolution crystal structure.",
        "keywords": [
            "fad-containing enzyme",
            "mitochondrial inner membrane protein",
            "protoporphyrinogen ix oxidase",
            "vp-causing mutations"
        ],
        "authors": [
            {
                "name": "Xiaohong Qin",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Lele Wang",
                "org": ""
            },
            {
                "name": "Zhifang Wang",
                "org": ""
            },
            {
                "name": "Baifan Wang",
                "org": ""
            },
            {
                "name": "Xin Wen",
                "org": ""
            },
            {
                "name": "Guangfu Yang",
                "org": ""
            },
            {
                "name": "Zhen Xi",
                "org": ""
            },
            {
                "name": "Yuequan Shen",
                "org": ""
            }
        ],
        "venue": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology",
        "year": 2011
    },
    "RuqENlBt": {
        "id": "RuqENlBt",
        "title": "Design and synthesis of 1-(benzothiazol-5-yl)-1H-1,2,4-triazol-5-ones as protoporphyrinogen oxidase inhibitors.",
        "abstract": "Protoporphyrinogen oxidase (PPO, E.C. 1.3.3.4) is the action target for several structurally diverse herbicides. A series of novel 4-(difluoromethyl)-1-(6-halo-2-substituted-benzothiazol-5-yl)-3-methyl-1H-1,2,4-triazol-5(4H)-ones 2a-z were designed and synthesized via the ring-closure of two ortho-substituents. The in vitro bioassay results indicated that the 26 newly synthesized compounds exhibited good PPO inhibition effects with K(i) values ranging from 0.06 to 17.79 \u03bcM. Compound 2e, ethyl 2-{[5-(4-(difluoromethyl)-3-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-6-fluorobenzo-thiazol-2-yl]thio}acetate, was the most potent inhibitor with K(i) value of 0.06 \u03bcM against mtPPO, comparable to (K(i)=0.03 \u03bcM) sulfentrazone. Further green house assays showed that compound 2f (K(i)=0.24 \u03bcM, mtPPO), ethyl 2-{[5-(4-(difluoromethyl)-3-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-6-fluorobenzothiazol-2-yl]thio}propanoate, showed the most promising post-emergence herbicidal activity with broad spectrum even at concentrations as low as 37.5 gai/ha. Soybean exhibited tolerance to compound 2f at the dosages of 150 gai/ha, whereas they are susceptible to sulfentrazone even at 75 gai/ha. Thus, compound 2f might be a potential candidate as a new herbicide for soybean fields.",
        "keywords": [
            "molecular design",
            "protoporphyrinogen oxidase",
            "1",
            "benzothiazole",
            "herbicide",
            "2",
            "4-triazol-5-one"
        ],
        "authors": [
            {
                "name": "Yang Zuo",
                "org": ""
            },
            {
                "name": "Sheng-Gang Yang",
                "org": ""
            },
            {
                "name": "Yan-Ping Luo",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Ge-Fei Hao",
                "org": ""
            },
            {
                "name": "Qiong-You Wu",
                "org": ""
            },
            {
                "name": "Zhen Xi",
                "org": ""
            },
            {
                "name": "Guang-Fu Yang",
                "org": ""
            }
        ],
        "venue": "Bioorganic & medicinal chemistry",
        "year": 2013
    },
    "JVRcwHPl": {
        "id": "JVRcwHPl",
        "title": "Site-directed mutagenesis and computational study of the Y366 active site in Bacillus subtilis protoporphyrinogen oxidase.",
        "abstract": "Protoporphyrinogen IX oxidase (PPO), the last common enzyme of heme and chlorophyll biosynthesis, catalyses the oxidation\n of protoporphyrinogen IX to protoporphyrin IX, with FAD as cofactor. Among PPO, Bacillus subtilis PPO (bsPPO) is unique because of its broad substrate specificity and resistance to inhibition by diphenylethers. Identification of\n the activity of bsPPO would help us to understand the catalysis and resistance mechanisms. Based on the modeling and docking studies, we found\n that Y366 site in bsPPO was adjacent to substrate and FAD. In order to evaluate the functional role of this site, three mutants Y366A Y366E and\n Y366H were cloned and kinetically characterized. The efficiency of catalysis for Y366A and Y366H reduced to 10% of the wild-type\n enzyme\u2019s activity, while Y366E just retained 1%. Y366E shows large resistance (K\n i\u00a0=\u00a0153.94\u00a0\u03bcM) to acifluorfen. Molecular docking was carried out to understand the structure and functional relationship of\n PPO. The experimental results from the site-directed mutagenesis are consistent with the computational studies. The residue\n at position 366 is seemed to be responsible for substrate binding and catalysis and involved in herbicide resistance of bsPPO.",
        "keywords": [
            "kinetics",
            "molecular docking",
            "protoporphyrinogen oxidase",
            "site-directed mutagenesis",
            "active site",
            "site directed mutagenesis",
            "enzyme",
            "wild type"
        ],
        "authors": [
            {
                "name": "Lu Sun",
                "org": "State Key Laboratory of Elemento-Organic Chemistry, Department of Chemical Biology,Nankai University,Tianjin,China"
            },
            {
                "name": "Xin Wen",
                "org": "State Key Laboratory of Elemento-Organic Chemistry, Department of Chemical Biology,Nankai University,Tianjin,China"
            },
            {
                "name": "Ying Tan",
                "org": "State Key Laboratory of Elemento-Organic Chemistry, Department of Chemical Biology,Nankai University,Tianjin,China"
            },
            {
                "name": "Heyang Li",
                "org": "State Key Laboratory of Elemento-Organic Chemistry, Department of Chemical Biology,Nankai University,Tianjin,China"
            },
            {
                "name": "Xing Yang",
                "org": "State Key Laboratory of Elemento-Organic Chemistry, Department of Chemical Biology,Nankai University,Tianjin,China"
            },
            {
                "name": "Yuefang Zhao",
                "org": "State Key Laboratory of Elemento-Organic Chemistry, Department of Chemical Biology,Nankai University,Tianjin,China"
            },
            {
                "name": "Baifan Wang",
                "org": "State Key Laboratory of Elemento-Organic Chemistry, Department of Chemical Biology,Nankai University,Tianjin,China"
            },
            {
                "name": "Qiongyao Cao",
                "org": "State Key Laboratory of Elemento-Organic Chemistry, Department of Chemical Biology,Nankai University,Tianjin,China"
            },
            {
                "name": "Congwei Niu",
                "org": "State Key Laboratory of Elemento-Organic Chemistry, Department of Chemical Biology,Nankai University,Tianjin,China"
            },
            {
                "name": "Zhen Xi",
                "org": "State Key Laboratory of Elemento-Organic Chemistry, Department of Chemical Biology,Nankai University,Tianjin,China"
            }
        ],
        "venue": "Amino acids",
        "year": 2009
    },
    "usj9yTWa": {
        "id": "usj9yTWa",
        "title": "Quantitative structural insight into human variegate porphyria disease.",
        "abstract": "Defects in the human protoporphyrinogen oxidase (hPPO) gene, resulting in ~50% decreased activity of hPPO, is responsible for the dominantly inherited disorder variegate porphyria (VP). To understand the molecular mechanism of VP, we employed the site-directed mutagenesis, biochemical assays, structural biology, and molecular dynamics simulation studies to investigate VP-causing hPPO mutants. We report here the crystal structures of R59Q and R59G mutants in complex with acifluorfen at a resolution of 2.6 and 2.8 \u212b. The r.m.s.d. of the C\u03b1 atoms of the active site structure of R59G and R59Q with respect to the wild-type was 0.20 and 0.15 \u212b, respectively. However, these highly similar static crystal structures of mutants with the wild-type could not quantitatively explain the observed large differences in their enzymatic activity. To understand how the hPPO mutations affect their catalytic activities, we combined molecular dynamics simulation and statistical analysis to quantitatively understand the molecular mechanism of VP-causing mutants. We have found that the probability of the privileged conformations of hPPO can be correlated very well with the k(cat)/K(m) of PPO (correlation coefficient, R(2) > 0.9), and the catalytic activity of 44 clinically reported VP-causing mutants can be accurately predicted. These results indicated that the VP-causing mutation affect the catalytic activity of hPPO by affecting the ability of hPPO to sample the privileged conformations. The current work, together with our previous crystal structure study on the wild-type hPPO, provided the quantitative structural insight into human variegate porphyria disease.",
        "keywords": [
            "flavoproteins",
            "protoporphyrinogen oxidase",
            "catalysis"
        ],
        "authors": [
            {
                "name": "Baifan Wang",
                "org": ""
            },
            {
                "name": "Xin Wen",
                "org": ""
            },
            {
                "name": "Xiaohong Qin",
                "org": ""
            },
            {
                "name": "Zhifang Wang",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Yuequan Shen",
                "org": ""
            },
            {
                "name": "Zhen Xi",
                "org": ""
            }
        ],
        "venue": "The Journal of biological chemistry",
        "year": 2013
    },
    "KxtiNpKS": {
        "id": "KxtiNpKS",
        "title": "Computational and experimental insights into the mechanism of substrate recognition and feedback inhibition of protoporphyrinogen oxidase.",
        "abstract": "Protoporphyrinogen IX oxidase (PPO; EC 1.3.3.4) is an essential enzyme catalyzing the last common step in the pathway leading to heme and chlorophyll biosynthesis. Great interest in PPO inhibitors arises from both its significance to agriculture and medicine. However, the discovery of PPO inhibitors with ultrahigh potency and selectivity is hampered due to lack of structural and mechanistic understanding about the substrate recognition, which remains a longstanding question central in porphyrin biology. To understand the mechanism, a novel binding model of protogen (protoporphyrinogen IX, the substrate) was developed through extensive computational simulations. Subsequently, amino acid residues that are critical for protogen binding identified by computational simulations were substituted by mutagenesis. Kinetic analyses of these mutants indicated that these residues were critical for protogen binding. In addition, the calculated free energies of protogen binding with these mutants correlated well with the experimental data, indicating the reasonability of the binding model. On the basis of this novel model, the fundamental mechanism of substrate recognition was investigated by performing potential of mean force (PMF) calculations, which provided an atomic level description of conformational changes and pathway intermediates. The free energy profile revealed a feedback inhibition mechanism of proto (protoporphyrin IX, the product), which was also in agreement with experimental evidence. The novel mechanistic insights obtained from this study present a new starting point for future rational design of more efficient PPO inhibitors based on the product-bound PPO structure.",
        "keywords": [
            "kinetics",
            "fluorescence",
            "protoporphyrinogen oxidase",
            "thermodynamics",
            "hydrogen bonding",
            "biocatalysis",
            "computer simulation"
        ],
        "authors": [
            {
                "name": "Ge-Fei Hao",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Sheng-Gang Yang",
                "org": ""
            },
            {
                "name": "Zhi-Fang Wang",
                "org": ""
            },
            {
                "name": "Chang-Guo Zhan",
                "org": ""
            },
            {
                "name": "Zhen Xi",
                "org": ""
            },
            {
                "name": "Guang-Fu Yang",
                "org": ""
            }
        ],
        "venue": "PloS one",
        "year": 2013
    },
    "5AYiQsUl": {
        "id": "5AYiQsUl",
        "title": "Understanding resistance mechanism of protoporphyrinogen oxidase-inhibiting herbicides: insights from computational mutation scanning and site-directed mutagenesis.",
        "abstract": "The potential of protoporphyrinogen oxidase (PPO) to develop resistance against five PPO-inhibiting herbicides has been studied using computational mutation scanning (CMS) protocol, leading to valuable insights into the resistance mechanisms and structure-resistance relationship of the PPO inhibitors. The calculated shifts in the binding free energies caused by the mutations correlated very well with those derived from the corresponding experimental data obtained from site-directed mutagenesis of PPO, leading to valuable insights into the resistance mechanisms of PPO inhibitors. The calculated entropy change was related to the conformational flexibility of the inhibitor, which demonstrated that inhibitors with appropriate conformational flexibility may inhibit both the wild type and mutants simultaneously. The reasonable correlation between the computational and experimental data further validate that CMS protocol is valuable for predicting resistance associated with amino acid mutations on target proteins.",
        "keywords": [],
        "authors": [
            {
                "name": "Ge-Fei Hao",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Wei-Fang Xu",
                "org": ""
            },
            {
                "name": "Run-Jie Cao",
                "org": ""
            },
            {
                "name": "Zhen Xi",
                "org": ""
            },
            {
                "name": "Guang-Fu Yang",
                "org": ""
            }
        ],
        "venue": "Journal of agricultural and food chemistry",
        "year": 2014
    },
    "Mn6YjiyK": {
        "id": "Mn6YjiyK",
        "title": "A capillary electrophoresis assay for recombinant Bacillus subtilis protoporphyrinogen oxidase.",
        "abstract": "Protoporphyrinogen oxidase (PPO) is a flavin adenine dinucleotide (FAD)-containing enzyme in the tetrapyrrole biosynthetic pathway that leads to the formation of both heme and chlorophylls, which has been identified as one of the most important action targets of commercial herbicides. The literature reports gave different PPO-catalytic kinetic parameters for the substrate protoporphyrinogen IX (K(m) of 0.1 to 10.4 miocroM) with different sources of PPO using fluorescent or HPLC methods. Herein we assayed the enzymatic activity of recombinant Bacillus subtilis PPO by using capillary electrophoresis (CE), a method with high separation efficiency, easy automation, and low sample consumption. The Michaelis constant and maximum reaction velocity were determined as 7.0+/-0.6 miocroM and 0.38+/-0.02 miocromol min(-1)miocrog(-1), respectively. The interaction between PPO and acifluorfen, a commercial PPO-inhibiting herbicide, was measured as the inhibition constant 186.9+/-9.3 miocroM EM, Cyrillic. The relationship between cofactor FAD and PPO activity can also be quantitatively studied by this CE method. The CE method used here should also be a convenient, reliable method for PPO study.",
        "keywords": [
            "capillary electrophoresis",
            "protoporphyrinogen oxidase",
            "herbicide",
            "kinetics",
            "fad",
            "enzyme"
        ],
        "authors": [
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Lu Sun",
                "org": ""
            },
            {
                "name": "Zhen Xi",
                "org": ""
            },
            {
                "name": "Guang-Fu Yang",
                "org": ""
            },
            {
                "name": "Dong-Qing Jiang",
                "org": ""
            },
            {
                "name": "Xiu-Ping Yan",
                "org": ""
            },
            {
                "name": "Xing Yang",
                "org": ""
            },
            {
                "name": "He-Yang Li",
                "org": ""
            }
        ],
        "venue": "Analytical biochemistry",
        "year": 2008
    },
    "FNm5X9gw": {
        "id": "FNm5X9gw",
        "title": "Design and syntheses of novel N -(benzothiazol-5-yl)-4,5,6,7-tetrahydro-1 H -isoindole-1,3(2 H)-dione and N -(benzothiazol-5-yl)isoindoline-1,3-dione as potent protoporphyrinogen oxidase inhibitors",
        "abstract": "Discovery of protoporphyrinogen oxidase (PPO, EC 1.3.3.4) inhibitors has been one of the hottest research areas in the field of herbicide development for many years. As a continuation of our research work on the development of new PPO-inhibiting herbicides, a series of novel N-(benzothiazol-5-yl)-4,5,6,7- tetrahydro-1H-isoindole-1,3(2H)-diones (1a-p) and N-(benzothiazol-5-yl) isoindoline-1,3-diones (2a-h) were designed and synthesized according to the ring-closing strategy of two ortho-substituents. The bioassay results indicated that some newly synthesized compounds exhibited higher PPO inhibition activity than the control of sulfentrazone. Compound 1a, S-(5-(1,3-dioxo-4,5,6,7- tetrahydro-1H-isoindol-2(3H)-yl)-6-fluorobenzothiazol-2-yl) O-methyl carbonothioate, was identified as the most potent inhibitor with ki value of 0.08 \u03bcM, about 9 times higher than that of sulfentrazone (k i = 0.72 \u03bcM). Further green house assay showed that compound 1b, methyl 2-((5-(1,3-dioxo-4,5,6,7-tetrahydro-1H-isoindol-2(3H)-yl)-6- fluorobenzothiazol-2-yl)thio)acetate, exhibited herbicidal activity comparable to that of sulfentrazone even at a concentration of 37.5 g ai/ha. In addition, among six tested crops, wheat exhibited high tolerance to compound 1b even at a dosage of 300 g ai/ha. These results indicated that compound 1b might have the potential to be developed as a new herbicide for weed control of wheat field. \u00a9 2011 American Chemical Society.",
        "keywords": [
            "4",
            "5",
            "6",
            "7-tetrahydro-1H-isoindole-1",
            "3(2H)-dione",
            "benzothiazole",
            "herbicide",
            "isoindoline-1",
            "3-dione",
            "protoporphyrinogen oxidase"
        ],
        "authors": [
            {
                "name": "Li-Li Jiang",
                "org": "Huazhong Normal University(Central China Normal University,Huazhong Normal University),Wuhan,China"
            },
            {
                "name": "Yang Zuo",
                "org": "Huazhong Normal University(Central China Normal University,Huazhong Normal University),Wuhan,China"
            },
            {
                "name": "Zhi-Fang Wang",
                "org": "Huazhong Normal University(Central China Normal University,Huazhong Normal University),Wuhan,China"
            },
            {
                "name": "Yin Tan",
                "org": "Huazhong Normal University(Central China Normal University,Huazhong Normal University),Wuhan,China"
            },
            {
                "name": "Qiong-You Wu",
                "org": "Huazhong Normal University(Central China Normal University,Huazhong Normal University),Wuhan,China"
            },
            {
                "name": "Zhen Xi",
                "org": "Nankai University(Nankai University),Tianjin,China"
            },
            {
                "name": "Guang-Fu Yang",
                "org": "Huazhong Normal University(Central China Normal University,Huazhong Normal University),Wuhan,China"
            }
        ],
        "venue": "Journal of Agricultural and Food Chemistry",
        "year": 2011
    },
    "EEZs21mx": {
        "id": "EEZs21mx",
        "title": "Structural insight into unique properties of protoporphyrinogen oxidase from Bacillus subtilis.",
        "abstract": "Protoporphyrinogen IX oxidase (PPO) converts protoporphyrinogen IX to protoporphyrin IX, playing an important part in the heme/chlorophyll biosynthetic pathway. Bacillus subtilis PPO (bsPPO) is unique among PPO family members in that it is a soluble monomer, is inefficiently inhibited by the herbicide acifluorfen (AF) and has broader substrate specificity than other PPO enzymes. Here, we present the crystal structure of bsPPO bound to AF. Our structure shows that the AF molecule binds to a new site outside the previously identified inhibitor binding pocket. Most importantly, the benzene ring of the 2-nitrobenzoic acid moiety of AF lies parallel to the isoalloxazine ring of FAD at a distance of less than 3.5A, providing a framework for the interaction of FAD with the substrate protoporphyrinogen IX. Furthermore, our structure reveals that the larger substrate binding chamber and predominantly positively charged chamber surface of bsPPO are more favorable for the binding of coproporphyrinogen-III. These crystallographic findings uncover biochemically unique properties of bsPPO, providing important information for further understanding the enzymatic mechanism.",
        "keywords": [
            "bsppo",
            "acifluorfen",
            "protoporphyrinogen ix oxidase",
            "tetrapyrrole biosynthesis",
            "variegate porphyria",
            "enzyme",
            "crystal structure"
        ],
        "authors": [
            {
                "name": "Xiaohong Qin",
                "org": ""
            },
            {
                "name": "Lu Sun",
                "org": ""
            },
            {
                "name": "Xin Wen",
                "org": ""
            },
            {
                "name": "Xue Yang",
                "org": ""
            },
            {
                "name": "Ying Tan",
                "org": ""
            },
            {
                "name": "Hao Jin",
                "org": ""
            },
            {
                "name": "Qiongyao Cao",
                "org": ""
            },
            {
                "name": "Weihong Zhou",
                "org": ""
            },
            {
                "name": "Zhen Xi",
                "org": ""
            },
            {
                "name": "Yuequan Shen",
                "org": ""
            }
        ],
        "venue": "Journal of structural biology",
        "year": 2010
    },
    "D91F1duA": {
        "id": "D91F1duA",
        "title": "Design, syntheses and 3D-QSAR studies of novel N-phenyl pyrrolidin-2-ones and N-phenyl-1H-pyrrol-2-ones as protoporphyrinogen oxidase inhibitors.",
        "abstract": "The characteristics of low application rates, good crop selectivity, low residue and environmental safety exhibited by Protoporphyrinogen oxidase (PPO, EC 1.3.3.4)-inhibiting herbicides have attracted a world-wide research interests. As continuation of our research work on the development of new PPO inhibitors, a series of mono-carbonyl analogues of cyclic imides, N-phenyl pyrrolidin-2-ones and N-phenyl-1H-pyrrol-2-ones, were designed and synthesized based on previously established DFT-QSAR results. The PPO inhibition activities of 29 newly synthesized compounds were tested and a predictive comparative molecular field analysis (CoMFA) model was established with the conventional correlation coefficient r(2)=0.980 and the cross-validated coefficient q(2)=0.518. According to the CoMFA model, the substituent effects on the PPO inhibition activity were explained reasonably. Further greenhouse assay showed that 2-(4-chloro-2-fluoro-5-propoxy-phenyl)-2,3,4,5,6,7-hexahydro-isoindol-1-one (C(6), k(i)=0.095\u03bcM) and 2-(5-allyloxy-4-chloro-2-fluorophenyl)-2,3,4,5,6,7-hexahydro-isoindol-1-one (C(7), k(i)=0.12\u03bcM) displayed excellent post-emergency herbicidal activity at the concentration of 150g.ai/ha against seven tested weeds. Due to their high PPO inhibition effect and broad spectrum herbicidal activity, these two compounds have the potential for further study on crop selectivity and field trial. These results confirmed once again that only one of the carbonyl groups of cyclic imides is essential to the PPO inhibition activity.",
        "keywords": [
            "n-phenyl-1h-pyrrol-2-one",
            "comfa",
            "n-phenyl pyrrolidin-2-one",
            "protoporphyrinogen oxidase",
            "herbicide"
        ],
        "authors": [
            {
                "name": "Li Zhang",
                "org": ""
            },
            {
                "name": "Yin Tan",
                "org": ""
            },
            {
                "name": "Neng-Xue Wang",
                "org": ""
            },
            {
                "name": "Qiong-You Wu",
                "org": ""
            },
            {
                "name": "Zhen Xi",
                "org": ""
            },
            {
                "name": "Guang-Fu Yang",
                "org": ""
            }
        ],
        "venue": "Bioorganic & medicinal chemistry",
        "year": 2010
    },
    "sJOeWZ5D": {
        "id": "sJOeWZ5D",
        "title": "Bioactive conformation analysis of cyclic imides as protoporphyrinogen oxidase inhibitor by combining DFT calculations, QSAR and molecular dynamic simulations.",
        "abstract": "Bioactive conformation of drugs is one of the key points for understanding the ligand-receptor interactions. In the present study, by combining density functional theory-based (DFT-based) conformation analysis with quantitative structure-activity relationship analysis (QSAR), we developed successfully a new approach (DFT/QSAR) to carry out bioactive conformation analyses for a series of 25 cyclic imide derivatives as protoporphyrinogen oxidase (PPO) inhibitors. Further potential energy surface scan, molecular docking and molecular dynamic simulation calculations validated that the DFT/QSAR-derived conformation is indeed very similar to the 'real' bioactive conformation. We believe the DFT/QSAR approach provides a simple alternative for the bioactive conformation of small molecules, especially in the case that the three-dimensional structure of protein is unknown.",
        "keywords": [
            "dft",
            "ppo",
            "bioactive conformation",
            "qsar",
            "molecular dynamic simulations",
            "quantitative structure activity relationship",
            "molecular docking",
            "potential energy surface",
            "density function theory",
            "dynamic simulation"
        ],
        "authors": [
            {
                "name": "Li Zhang",
                "org": ""
            },
            {
                "name": "Ge-Fei Hao",
                "org": ""
            },
            {
                "name": "Yin Tan",
                "org": ""
            },
            {
                "name": "Zhen Xi",
                "org": ""
            },
            {
                "name": "Ming-Zhi Huang",
                "org": ""
            },
            {
                "name": "Guang-Fu Yang",
                "org": ""
            }
        ],
        "venue": "Bioorganic & medicinal chemistry",
        "year": 2009
    },
    "yZMqyH77": {
        "id": "yZMqyH77",
        "title": "Analysis and Comparison of Multiple Beam Lidars for Wind Measurement",
        "abstract": "The multiple beam wind lidar measures the vertical profiles of wind velocity by tracking the particulate structures,or the spatial variations in the particulate concentration(or more precisely,in the scattering intensity).The results depend upon the large-scale particulate structure and the assumption of frozen turbulence.The lidar device is relatively simple and not expensive.In this paper,two methods of the multiple beam lidar for the wind measurement are analyzed and compared.One method uses the correlations of lidar signals from multiple lines of sight.Another method uses the ratio of Fourier transforms of two multibeam lidar signals.The latter enables the measurement of the horizontal wind vector using a relatively fast computational algorithm.",
        "keywords": [
            "lidar",
            "wind measurement",
            "aerosol",
            "multiple beam"
        ],
        "authors": [
            {
                "name": "TAN Ying",
                "org": "Key Laboratory of Geospace Environment and Geodesy,Ministry of Education,School of Electronic Information,Wuhan University,Wuhan ,China;State Observatory for Atmospheric Remote Sensing,Wuhan ,China;Sate Key Laboratory of Space Weather,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "WU Xiaying",
                "org": "Key Laboratory of Geospace Environment and Geodesy,Ministry of Education,School of Electronic Information,Wuhan University,Wuhan ,China;State Observatory for Atmospheric Remote Sensing,Wuhan ,China"
            },
            {
                "name": "DING Ying",
                "org": "Key Laboratory of Geospace Environment and Geodesy,Ministry of Education,School of Electronic Information,Wuhan University,Wuhan ,China;State Observatory for Atmospheric Remote Sensing,Wuhan ,China"
            },
            {
                "name": "YI Fan",
                "org": "Key Laboratory of Geospace Environment and Geodesy,Ministry of Education,School of Electronic Information,Wuhan University,Wuhan ,China;State Observatory for Atmospheric Remote Sensing,Wuhan ,China"
            }
        ],
        "venue": "Science & Technology Review",
        "year": 2011
    },
    "VfVpxFEs": {
        "id": "VfVpxFEs",
        "title": "Optical communication system design of formation flying micro-satellites",
        "abstract": "Because of the advantage of optical communication,it can be adapted for formation flying micro-satellites systems. Based on the character of flying micro-satellites systems,a model is built. The influence on optical communication link owing to satellite vibration is analyzed. Additionally a practical system of formation flying micro-satellites optical communication is designed.",
        "keywords": [
            "fiber array",
            "formation micro-satellites",
            "link",
            "ATP"
        ],
        "authors": [
            {
                "name": "CHEN Jing",
                "org": "School of Electronic Information,Wuhan University,Wuhan ,China"
            },
            {
                "name": "AI Yong",
                "org": "School of Electronic Information,Wuhan University,Wuhan ,China"
            },
            {
                "name": "TAN Ying",
                "org": "School of Electronic Information,Wuhan University,Wuhan ,China"
            },
            {
                "name": "YE De-mao",
                "org": "School of Electronic Information,Wuhan University,Wuhan ,China"
            },
            {
                "name": "CAO Yang",
                "org": "School of Electronic Information,Wuhan University,Wuhan ,China"
            }
        ],
        "venue": "Optical Communication Technology",
        "year": 2007
    },
    "1NfzB0PX": {
        "id": "1NfzB0PX",
        "title": "Beacon tracking system based on DSP technology",
        "abstract": "The establishment of satellite-ground laser link faces three problems nowadays, which are long distance communication, real-time processing and high precision pointing. To solve these problems, a beacon tracking system was presented, which adopted DSP (TMS320DM642) as core processor, combining with CCD, video decoder chip, SDRAM, and peripheral circuits. The design principle of the system was also proposed. According to the variable-speed motion of the satellite, an adaptive rank selection algorithm based on the least mean square(LMS) method was introduced to dynamically predict the simulated satellite movement. The results show that the method can trace target under the complex conditions.",
        "keywords": [
            "Beacon",
            "DSP",
            "Least mean square",
            "Tracking"
        ],
        "authors": [
            {
                "name": "YE De-mao",
                "org": "Wuhan University(Wuhan University),Wuhan,China"
            },
            {
                "name": "Yong Ai",
                "org": "Wuhan University(Wuhan University),Wuhan,China"
            },
            {
                "name": "Yang Cao",
                "org": "Wuhan University(Wuhan University),Wuhan,China"
            },
            {
                "name": "Ying Tan",
                "org": "Wuhan University(Wuhan University),Wuhan,China"
            },
            {
                "name": "Jing Chen",
                "org": "Wuhan University(Wuhan University),Wuhan,China"
            },
            {
                "name": "GUO Jian-zhong",
                "org": "Wuhan University(Wuhan University),Wuhan,China"
            }
        ],
        "venue": "Guangzi Xuebao/Acta Photonica Sinica",
        "year": 2008
    },
    "BLygFxhr": {
        "id": "BLygFxhr",
        "title": "Design of embedded wireless laser communication BER tester based on SOPC",
        "abstract": "This paper introduces a design and implementation of BER tester using for wireless laser communication, which is based on a SOPC design method. When integrating a NiosII embedded processor into FPGA, it could easily achieve some functions such as user-control interface that is used to implement in MCU. And this method replaces the traditional BER tester's FPGA+MCU structure, and greatly improves the BER tester's integration and stability. And also, a CDR(Clock and Data Recovery) circuit is devised, so that it could allow the transmit and receive terminals are apart far away. At the end of this paper, some experiment results are given, which are recorded by the BER Tester in a 16km wireless laser communication experiment in Beijing.",
        "keywords": [
            "BER",
            "wireless laser communication",
            "CDR",
            "SOPC"
        ],
        "authors": [
            {
                "name": "WU Wei-qi",
                "org": "School of Electronic Information Wuhan Unversity, Wuhan ,China"
            },
            {
                "name": "AI Yong",
                "org": "School of Electronic Information Wuhan Unversity, Wuhan ,China"
            },
            {
                "name": "ZUO Tao",
                "org": "School of Electronic Information Wuhan Unversity, Wuhan ,China"
            },
            {
                "name": "TAN Ying",
                "org": "School of Electronic Information Wuhan Unversity, Wuhan ,China"
            }
        ],
        "venue": "Optical Communication Technology",
        "year": 2008
    },
    "eJbxJyhv": {
        "id": "eJbxJyhv",
        "title": "Design of BER tester using for FSO communication",
        "abstract": "This paper introduces a design and implementation of BER tester using for FSO communicationsystem.This BER tester is based on AT89S52 MCU and EP1K30 FPGA.The FPGA is to achieve high-speed,error detection,while the MCU takes charge of controlling logic.And the paper has discussed the pseudo-ran-dom code generator module,error detection module,the synchronization module and the interface of MCUand FPGA.And then,some experiment results are given to prove that the design of BER tester can work stableand reliable.",
        "keywords": [
            "BER test",
            "FSO",
            "pseudo random sequence",
            "FPGA"
        ],
        "authors": [
            {
                "name": "WU Wei-qi",
                "org": "School of Electronic Information Wuhan Unversity,Wuhan ,China"
            },
            {
                "name": "DAI Yong-hong",
                "org": "School of Electronic Information Wuhan Unversity,Wuhan ,China"
            },
            {
                "name": "TAN Ying",
                "org": "School of Electronic Information Wuhan Unversity,Wuhan ,China"
            },
            {
                "name": "AI Yong",
                "org": "School of Electronic Information Wuhan Unversity,Wuhan ,China"
            }
        ],
        "venue": "Optical Communication Technology",
        "year": 2007
    },
    "oNqU2jvd": {
        "id": "oNqU2jvd",
        "title": "Ground simulation experiment of fine tracking for spatial optical communication",
        "abstract": "A simple demonstration system for fine tracking is put forward, and the component is presented in detail. The centroid algorithm is the traditional method for beacon, and it has a systematic error and a random one. So it is obligatory to adopt the pixel subtraction. With the PID-like neural network algorithm, the weights of neural network and the parameters could be adjusted to reduce beacon vibration by the function of self-learning and adaptability in real time. The experimental results show the pixel subtraction improves the precision of centroid algorithm, and the PID-like neural network algorithm is robust. The fine tracking system can track 50 Hz beacon vibration with CCD of 400 Hz, and the range of beacon vibration reduces 25.7%, which is beneficial for the system to apply.",
        "keywords": [
            "Fine tracking",
            "PID-like neural network",
            "Pixel subtraction",
            "Spatial optical communication"
        ],
        "authors": [
            {
                "name": "Yang Cao",
                "org": "Wuhan University(Wuhan University),Wuhan,China"
            },
            {
                "name": "Yong Ai",
                "org": "Wuhan University(Wuhan University),Wuhan,China"
            },
            {
                "name": "Ming Li",
                "org": "Wuhan University(Wuhan University),Wuhan,China"
            },
            {
                "name": "Ying Tan",
                "org": "Wuhan University(Wuhan University),Wuhan,China"
            }
        ],
        "venue": "Guangdianzi Jiguang/Journal of Optoelectronics Laser",
        "year": 2009
    },
    "6eibmVIk": {
        "id": "6eibmVIk",
        "title": "Fading statistics for 16 km horizontal laser link propagation under aperture receiving condition",
        "abstract": "To study statistical properties of irradiance scintillation of long distance horizontal laser link, a 16 km propagation experiment was carried out. The fading statistics obtained from experimental data were compared to theoretical predictions based on the lognormal and gamma-gamma distributions. It is found that the irradiance scintillation analyzed by the gamma-gamma and lognormal distributions provides an upper and lower signal bound, respectively, under a bigger aperture. While under a smaller aperture receiving condition, only gamma-gamma distribution fits the data well. For effects of irradiance saturation and aperture average, the fading threshold of the 16km laser link is only 6~10 dB under a 10-6 probability of fading.",
        "keywords": [
            "Aperture receiving",
            "Horizontal link",
            "Laser propagation",
            "Optical signal fade"
        ],
        "authors": [
            {
                "name": "Jing Chen",
                "org": "Wuhan University(Wuhan University),Wuhan,China"
            },
            {
                "name": "Yong Ai",
                "org": "Wuhan University(Wuhan University),Wuhan,China"
            },
            {
                "name": "YE De-mao",
                "org": "Wuhan University(Wuhan University),Wuhan,China"
            },
            {
                "name": "Ying Tan",
                "org": "Wuhan University(Wuhan University),Wuhan,China"
            }
        ],
        "venue": "Bandaoti Guangdian/Semiconductor Optoelectronics",
        "year": 2008
    },
    "uiPacxmm": {
        "id": "uiPacxmm",
        "title": "Ground simulation experiment of acquisition and tracking with beacon between the spatial movement platform",
        "abstract": "A beacon tracking servo system in spatial optical communication is designed with double DSP(TMS320LF2407A and TMS320DM642),Kalman method is adopted to forecast the target.The design of hardware and software system is described in detail,the scan time of beacon is presented from different experimental conditions,the scan error time of beacon is also analyzed.According to the experimental result,the system has a satisfied performance including high precision,quick scan,small volume,real-time.",
        "keywords": [
            "spatial optical communication",
            "acquisition",
            "Kalman",
            "tracking",
            "beacon"
        ],
        "authors": [
            {
                "name": "CAO Yang",
                "org": "School of Electronic Information,Wuhan University,Wuhan ,China"
            },
            {
                "name": "AI Yong",
                "org": "School of Electronic Information,Wuhan University,Wuhan ,China"
            },
            {
                "name": "YE De-mao",
                "org": "School of Electronic Information,Wuhan University,Wuhan ,China"
            },
            {
                "name": "HU Jun-jie",
                "org": "School of Electronic Information,Wuhan University,Wuhan ,China"
            },
            {
                "name": "TAN ying",
                "org": "School of Electronic Information,Wuhan University,Wuhan ,China"
            }
        ],
        "venue": "Journal of Optoelectronics.Laser",
        "year": 2008
    },
    "30OR0VHy": {
        "id": "30OR0VHy",
        "title": "2.3km 1.25Gb/s free space optical communication experiment",
        "abstract": "We describe a terrestrial free-space 2.3km optical data link operating at 1.25Gb/s. A new portable free-space optical communication system is designed . The aperture diameter of transmitter and receiver is only 40mm and the weight is 3.5kg. The communication wavelength is 1550 nm. Video, Ethernet and audio interface are included in the optical communication system.. The overall design, basic principle of the system, and optical communication experiment are described. The experiments proved that the aperture of free space optical communication system shall be large than the first radius of Fresnel band.",
        "keywords": [
            "space optical communication",
            "atmosphere scintillation",
            "laser atmospheric propagation"
        ],
        "authors": [
            {
                "name": "AI Yong",
                "org": "School of Electronic Information,Wuhan University,Wuhan , China"
            },
            {
                "name": "CHEN Jing",
                "org": "School of Electronic Information,Wuhan University,Wuhan , China"
            },
            {
                "name": "YE De-mao",
                "org": "School of Electronic Information,Wuhan University,Wuhan , China"
            },
            {
                "name": "SUN Hao",
                "org": "School of Electronic Information,Wuhan University,Wuhan , China"
            },
            {
                "name": "YANG Jin-ling",
                "org": "School of Electronic Information,Wuhan University,Wuhan , China"
            },
            {
                "name": "TAN Ying",
                "org": "School of Electronic Information,Wuhan University,Wuhan , China"
            }
        ],
        "venue": "Optical Communication Technology",
        "year": 2007
    },
    "X56CY7MG": {
        "id": "X56CY7MG",
        "title": "Performance analysis of LDPC coded pulse position modulation for deep-space optical communications",
        "abstract": "Performance of binary low-density parity check (LDPC) codes employing Q-ary pulse position modulation (PPM) and an avalanche photodiode (APD) is investigated in a deep space optical communications system in this paper. The performances of LDPC codes with various codeword length and various order of PPM modulation are given, and compared with Reed-Solomon (RS) codes. Simulations show that the performance of LDPC codes decreases rapidly as the order of modulation increases. In addition, the influence of the order of PPM upon the performance of LDPC codes is analyzed.",
        "keywords": [
            "deep space optical communication",
            "coding gain",
            "LDPC codes",
            "PPM",
            "RS codes"
        ],
        "authors": [
            {
                "name": "GUO Jian-zhong",
                "org": "School of Electronic Information, Wuhan University, Wuhan , China"
            },
            {
                "name": "TAN Ying",
                "org": "School of Electronic Information, Wuhan University, Wuhan , China"
            },
            {
                "name": "AI Yong",
                "org": "School of Electronic Information, Wuhan University, Wuhan , China"
            }
        ],
        "venue": "Optical Communication Technology",
        "year": 2007
    },
    "p8xWZlN4": {
        "id": "p8xWZlN4",
        "title": "A Food Chain System with Density-Dependent Birth Rate and impulsive Perturbations",
        "abstract": "",
        "keywords": [
            "biological control",
            "density-dependent birth",
            "extinction",
            "food chain model",
            "impulsive perturbation",
            "permanence",
            "floquet theory",
            "density dependence",
            "food chain"
        ],
        "authors": [
            {
                "name": "Shuwen Zhang",
                "org": ""
            },
            {
                "name": "Fenyan Wang",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Advances in Complex Systems",
        "year": 2006
    },
    "Au6DdJ6h": {
        "id": "Au6DdJ6h",
        "title": "Impulsive state feedback control of the microorganism culture in a turbidostat",
        "abstract": "In this paper, a mathematical model with the impulsive state feedback control is proposed for turbidostat system. The sufficient\n conditions of existence of order-1 and order-2 periodic solutions are obtained by the existence criteria of periodic solution\n of a general planar impulsive autonomous system. It is shown that the system either tends to a stable state or has a periodic\n solution, which depends on the feedback state and the initial concentration of microorganism and substrate. Finally, some\n discussions and numerical simulations are given.",
        "keywords": [
            "Turbidostat",
            "Impulsive state feedback control",
            "Period-1 solution",
            "Period-2 solution"
        ],
        "authors": [
            {
                "name": "Zhong Zhao",
                "org": "Huanghuai University Department of Mathematics 463000 Zhumadian Henan People\u2019s Republic of China"
            },
            {
                "name": "Li Yang",
                "org": "Huanghuai University Department of Mathematics 463000 Zhumadian Henan People\u2019s Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology Department of Applied Mathematics 116024 Dalian People\u2019s Republic of China"
            }
        ],
        "venue": "Journal of Mathematical Chemistry",
        "year": 2010
    },
    "RhmCj4wz": {
        "id": "RhmCj4wz",
        "title": "Periodic Solution of Prey-Predator Model with Beddington-DeAngelis Functional Response and Impulsive State Feedback Control.",
        "abstract": "A prey-predator model with Beddington-DeAngelis functional response and impulsive state feedback control is investigated. We obtain the sufficient conditions of the global asymptotical stability of the system without impulsive effects. By using the geometry theory of semicontinuous dynamic system and the method of successor function, we obtain the system with impulsive effects that has an order one periodic solution, and sufficient conditions for existence and stability of order one periodic solution are also obtained. Finally, numerical simulations are performed to illustrate our main results. \u00a9 2012 Chunjin Wei and Lansun Chen.",
        "keywords": [],
        "authors": [
            {
                "name": "Chunjin Wei",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "J. Applied Mathematics",
        "year": 2012
    },
    "y76jq02E": {
        "id": "y76jq02E",
        "title": "A predator\u2013prey model with disease in the prey and two impulses for integrated pest management",
        "abstract": "In this paper, a predator\u2013prey model with disease in the prey is constructed and investigated for the purpose of integrated pest management. In the first part of the main results, the sufficient condition for the global stability of the susceptible pest-eradication periodic solution is obtained, which means if the release amount of infective prey and predator satisfy the condition, then the pest will be controlled. The sufficient condition for the permanence of the system is also obtained subsequently, which means if the release amount of infective prey and predator satisfy the condition, then the prey and the predator will coexist. At last, we interpret our mathematical results.",
        "keywords": [
            "Predator\u2013prey model",
            "Permanent",
            "Impulsive",
            "Susceptible pest-eradication periodic solution"
        ],
        "authors": [
            {
                "name": "Ruiqing Shi",
                "org": ""
            },
            {
                "name": "Xiaowu Jiang",
                "org": "Department of Mathematics, Xinyang Normal University, Xinyang 464000, Henan, People\u2019s Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian, Liaoning 116024, People\u2019s Republic of China"
            }
        ],
        "venue": "Applied Mathematical Modelling",
        "year": 2009
    },
    "SVYBn8kb": {
        "id": "SVYBn8kb",
        "title": "Dynamical behavior of Volterra model with mutual interference concerning IPM",
        "abstract": "A Volterra model with mutual interference concerning integrated pest management is proposed and analyzed. By using Floquet theorem and small amplitude perturbation method and comparison theorem, we show the existence of a globally asymptotically stable pest-eradication periodic solution. Further, we prove that when the stability of pest-eradication periodic solution is lost, the system is permanent and there exists a locally stable positive periodic solution which arises from the pest-eradication periodic solution by bifurcation theory. When the unique positive periodic solution loses its stability, numerical simulation shows there is a characteristic sequence of bifurcations, leading to a chaotic dynamics. Finally, we compare the validity of integrated pest management (IPM) strategy with classical methods and conclude IPM strategy is more eective than classical methods. Mathematics Subject Classication. 34A37, 92D25.",
        "keywords": [
            "bifurcation",
            "chaos",
            "integrated pest management (ipm)",
            "mutual interference",
            "permanence",
            "numerical simulation",
            "bifurcation theory",
            "integrated pest management"
        ],
        "authors": [
            {
                "name": "Yujuan Zhang",
                "org": "Anshan Normal University(Anshan Normal University,Anshan Normal College),Anshan,China"
            },
            {
                "name": "Bing Liu",
                "org": "Anshan Normal University(Anshan Normal University,Anshan Normal College),Anshan,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            }
        ],
        "venue": "Mathematical Modelling and Numerical Analysis",
        "year": 2004
    },
    "PcC4a9vy": {
        "id": "PcC4a9vy",
        "title": "Analysis of a Holling IV One-Predator Two-Prey System With Impulsive Effect",
        "abstract": "A Holling type IV Lotka-Volterra one-predator two-prey system with impulsive effect on predator at fixed moments is investigated.Conditions for the stability of the trivial peridic solution and the permanence of the system are established via comparison theorem of impulsive differential equation and analytic methods of differential equation theory.",
        "keywords": [
            "Holling type IV",
            "extinction",
            "impulsive effect",
            "permanence",
            "predator-prey system"
        ],
        "authors": [
            {
                "name": "Pang Guoping",
                "org": "Department of Mathematics and Computer Sciences,Yulin Normal University,Yulin ,China;Department of Applied Mathematics,Dalian University of Technology,Dalian ,China"
            },
            {
                "name": "Chen Lansun",
                "org": "Department of Applied Mathematics,Dalian University of Technology,Dalian ,China;Minnan Science and Technology Institute,Fujian Normal University,Nan'an ,China"
            }
        ],
        "venue": "Journal of Nanjing Normal University(Natural Science Edition)",
        "year": 2007
    },
    "SIZ0IfOL": {
        "id": "SIZ0IfOL",
        "title": "Eco-epidemiology model with age structure and prey-dependent consumption for pest management",
        "abstract": "In this paper, a prey-dependent consumption predator\u2013prey (natural enemy-pest) model with age structure for the predators and infectious disease in the prey, is considered. Infectious pests, immature natural enemies and mature natural enemies are released impulsively. By using Floquet\u2019s theorem, small-amplitude perturbation skills and comparison theorem, we obtain both the sufficient conditions for the global asymptotical stability of the susceptible pest-eradication periodic solution and the permanence of the system. The results provide a reliable theoretical tactics for pest management.",
        "keywords": [
            "Global stability",
            "Permanence",
            "Impulsive",
            "Pest management",
            "Eco-epidemiology"
        ],
        "authors": [
            {
                "name": "Chunjin Wei",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, People\u2019s Republic of China"
            }
        ],
        "venue": "Applied Mathematical Modelling",
        "year": 2009
    },
    "yeGKNNWy": {
        "id": "yeGKNNWy",
        "title": "Optimal impulsive harvesting of a single-species with Gompertz Law of growth",
        "abstract": "In this paper we investigate the optimal harvesting problems of a single species with Gompertz law of growth. Based on continuous harvesting models, we propose impulsive harvesting models with constant harvest or proportional harvest. By using the discrete dynamical systems determined by the stroboscopic map, we discuss existence, stability and global attractivity of positive periodic solutions, and obtain the maximum sustainable yield and the corresponding optimal population level. At last, we compare the maximum sustainable yield of impulsive harvest with that of continuous harvest, and point out that proportional harvest is superior to constant harvest. \u00a9 World Scientific Publishing Company.",
        "keywords": [
            "global attractivity",
            "gompertz law",
            "impulsive harvest",
            "maximum sustainable yield"
        ],
        "authors": [
            {
                "name": "Yujuan Zhang",
                "org": "Anshan Normal University(Anshan Normal University,Anshan Normal College),Anshan,China"
            },
            {
                "name": "Zhilong Xiu",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and System Sciences Chinese Academy of Sciences(Chinese Academy of Sciences,Academy of Mathematics and Systems Science),Beijing,China"
            }
        ],
        "venue": "Journal of Biological Systems",
        "year": 2006
    },
    "8SCuPO5K": {
        "id": "8SCuPO5K",
        "title": "On a Periodic Time-Dependent Model of Population Dynamics with Stage Structure and Impulsive Effects",
        "abstract": "",
        "keywords": [
            "population dynamic"
        ],
        "authors": [
            {
                "name": "Kaiyuan Liu",
                "org": "Department of Mathematics|Anshan Normal University"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics|Dalian University of Technology"
            }
        ],
        "venue": "Discrete Dynamics in Nature and Society",
        "year": 2008
    },
    "YJM9wBCX": {
        "id": "YJM9wBCX",
        "title": "Analysis of a Three Species Eco-Epidemiological Model",
        "abstract": "This paper formulates and analyzes a predator\u2013prey model with disease in the prey. Mathematical analyses of the model equations with regard to invariance of nonnegativity, boundedness of solutions, nature of equilibria, permanence, and global stability are analyzed. It is also shown that for some parameter values, the positive equilibrium is asymptotically stable, but for other parameter values, it is unstable and a surrounding periodic solution appears by Hopf bifurcation. A concluding discussion with numerical simulation is then presented.",
        "keywords": [
            "hopf bifurcation",
            "global stability",
            "predator\u2013prey model",
            "permanence",
            "numerical simulation"
        ],
        "authors": [
            {
                "name": "Yanni Xiao",
                "org": "Academy of Mathematics & System Sciences, Academia Sinica, Beijing, 100080, P.R. China"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics & System Sciences, Academia Sinica, Beijing, 100080, P.R. China"
            }
        ],
        "venue": "Journal of Mathematical Analysis and Applications",
        "year": 2001
    },
    "ywfHnTyv": {
        "id": "ywfHnTyv",
        "title": "Modelling and analysis of integrated pest management strategy",
        "abstract": "",
        "keywords": [
            "Economic threshold",
            "IPM strategy",
            "Periodic solution",
            "State-dependent impulsive differential equations"
        ],
        "authors": [
            {
                "name": "Sanyi Tang",
                "org": "Academy of Mathematics and System Sciences Chinese Academy of Sciences(Chinese Academy of Sciences,Academy of Mathematics and Systems Science),Beijing,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and System Sciences Chinese Academy of Sciences(Chinese Academy of Sciences,Academy of Mathematics and Systems Science),Beijing,China"
            }
        ],
        "venue": "Discrete and Continuous Dynamical Systems - Series B",
        "year": 2004
    },
    "4tHNTOiF": {
        "id": "4tHNTOiF",
        "title": "The Dynamics of a Predator-prey Model with Ivlev\u2019s Functional Response Concerning Integrated Pest Management",
        "abstract": "\n Abstract\n \u00a0\u00a0A mathematical model of a predator-prey model with Ivlev\u2019s\n functional response concerning integrated pest management (IPM)\n is proposed and analyzed. We show that there exists a stable\n pest-eradication periodic solution when the impulsive period is\n less than some critical values. Further more, the conditions for\n the permanence of the system are given. By using bifurcation\n theory, we show the existence and stability of a positive\n periodic solution. These results are quite different from those\n of the corresponding system without impulses. Numerical\n simulation shows that the system we consider has more complex\n dynamical behaviors. Finally, it is proved that IPM stragey is\n more effective than the classical one.\n ",
        "keywords": [
            "ipm strategy",
            "ivlev's functional response",
            "extinction",
            "impulsive effect",
            "permanence"
        ],
        "authors": [
            {
                "name": "Bing Liu",
                "org": "Anshan Normal University Department of Mathematics Anshan, Liaoning 114005 China Anshan, Liaoning 114005 China"
            },
            {
                "name": "Ying Zhi",
                "org": "Anshan Normal University Department of Mathematics Anshan, Liaoning 114005 China Anshan, Liaoning 114005 China"
            },
            {
                "name": "Lan-sun Chen",
                "org": "Academy of Mathematics and Systems Science Beijing 100080 China Beijing 100080 China"
            }
        ],
        "venue": "Acta Mathematicae Applicatae Sinica-english Series",
        "year": 2004
    },
    "4jj4Sk9d": {
        "id": "4jj4Sk9d",
        "title": "Persistence and global stability for n-species ratio-dependent predator\u2013prey system with time delays",
        "abstract": "A n -species ratio-dependent predator\u2013prey food-chain model with time delays is investigated. It is shown that the system is permanent under some appropriate conditions, and sufficient conditions are obtained for the global stability of the positive equilibrium of the system.",
        "keywords": [
            "global stability",
            "persistence",
            "delay",
            "food chain"
        ],
        "authors": [
            {
                "name": "Rui Xu",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academia Sinica, Beijing 100080, PR China"
            }
        ],
        "venue": "Journal of Mathematical Analysis and Applications",
        "year": 2002
    },
    "rI3YEX22": {
        "id": "rI3YEX22",
        "title": "Persistence and global stability for a three-species ratio-dependent predator-prey system with time delays in two-patch environments",
        "abstract": "A three-species ratio-dependent predator-prey diffusion model with time delays is investigated. It is shown that the system is uniformly persistent under some appropriate conditions, and sufficient conditions are obtained for the global stability of the positive equilibrium of the system.",
        "keywords": [
            "Diffusion",
            "Global asymptotic stability",
            "Time delay",
            "Uniform persistence"
        ],
        "authors": [
            {
                "name": "Rui Xu",
                "org": "Shijiazhuang Mechanical Engineering College(Mechanical Engineering College,Shijiazhuang Mechanical Engineering College,College of Mechanical Engineering,Shijiazhuang Mech. Eng. College),Shijiazhuang,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            }
        ],
        "venue": "Acta Mathematica Scientia",
        "year": 2002
    },
    "aSqETzIl": {
        "id": "aSqETzIl",
        "title": "Global asymptotic stability of the periodic Lotka-Volterra System with two-predators and one-prey",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "chen lansun",
                "org": ""
            },
            {
                "name": "lu zhonghua",
                "org": ""
            }
        ],
        "venue": "Applied Mathematics-a Journal of Chinese Universities Series B",
        "year": 1995
    },
    "N7Rr5oWt": {
        "id": "N7Rr5oWt",
        "title": "Chaos in three species food chain system with impulsive perturbations",
        "abstract": "In this paper, we investigate three species food chain system with periodic constant impulsive perturbations of mid-level predator. Conditions for extinction of lowest-level prey and top predator are given. By using the Floquet theory of impulsive equation and small amplitude perturbation skills, we consider the local stability of lowest-level prey and top predator eradication periodic solution. Further, influences of the impulsive perturbations on the inherent oscillation are studied numerically, which shows the rich dynamics (for example: period doubling, period halfing, non-unique dynamics) in the positive octant. The dynamics behavior is found to be very sensitive to the parameter values and initial value.",
        "keywords": [
            "oscillations",
            "food chain",
            "floquet theory"
        ],
        "authors": [
            {
                "name": "Shuwen Zhang",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Liaoning, Dalian 116024, P.R. China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2005
    },
    "RaoWbmtI": {
        "id": "RaoWbmtI",
        "title": "The effect of dispersal on population growth with stage-structure",
        "abstract": "Declines in species richness or population are primarily attributed to habitat destruction and fragmentation. Can we avoid the local extinction of species with stage-structure in some patches by building some corridors between the patches and controlling the dispersal rates? A conservation strategy is put forward by introducing and analyzing the asymptotic behavior of some autonomous and time-varying population models. Biological implications of these results are discussed briefly.",
        "keywords": [],
        "authors": [
            {
                "name": "Jingan Cui",
                "org": "Institute of Mathematics, Academia Sinica Beijing 100080, P.R. China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academia Sinica Beijing 100080, P.R. China"
            },
            {
                "name": "Wendi Wang",
                "org": "Institute of Mathematics, Academia Sinica Beijing 100080, P.R. China"
            }
        ],
        "venue": "Computers and Mathematics with Applications",
        "year": 2000
    },
    "YFi1vxkH": {
        "id": "YFi1vxkH",
        "title": "Impulsive perturbations of a predator-prey system with modified Leslie-Gower and Holling type II schemes",
        "abstract": "In this paper, the dynamics of an impulsively controlled predator-prey model with modified Leslie-Gower and Holling type II schemes is analyzed. Choosing pest birth rate r 1 as control parameter, we show that there exists a globally asymptotically stable pest-eradication periodic solution when r 1 is less than some critical value 1 and the system is permanent when r 1 is larger than the critical value 1*. By use of standard techniques of bifurcation theory, we prove that this threshold there are periodic oscillations in pest and predator. Furthermore, some situations which leads to chaotic behavior of the system are investigated by means of numerical simulations. \u00a9 2009 Korean Society for Computational and Applied Mathematics.",
        "keywords": [
            "bifurcation",
            "chaos",
            "extinction",
            "periodic solution",
            "permanence",
            "oscillations",
            "critical value",
            "bifurcation theory",
            "numerical simulation"
        ],
        "authors": [
            {
                "name": "Zhong Zhao",
                "org": "Huanghuai University(Huanghuai University),Zhumadian,China"
            },
            {
                "name": "Li Yang",
                "org": "Huanghuai University(Huanghuai University),Zhumadian,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            }
        ],
        "venue": "Journal of Applied Mathematics and Computing",
        "year": 2011
    },
    "QUTHonij": {
        "id": "QUTHonij",
        "title": "Periodicity induced by state feedback controls and driven by disparate dynamics of a herbivore\u2013plankton model with cannibalism",
        "abstract": "Plankton and herbivore in aquatic ecosystems are often deeply disturbed by human exploitations in impulsive patterns. In this paper, for a herbivore\u2013plankton interaction model with cannibalism, firstly, the complex dynamic behaviors including the number, the existence and stability of internal equilibriums, the limit and homoclinic cycles, Hopf, saddle node, Pitchfork and Bogdanov\u2013Takens bifurcations are investigated roughly. Furthermore, multiple state feedback controls are implemented so that three order-one periodic solutions (OOPSs) and heteroclinic bifurcation driven by disparate dynamics are induced, respectively. By the method of Bendixson theorem and successor function, the existences of OOPSs are proved. Finally, for the corresponding small parameter-perturbed system, B-convergent of OOPS and homoclinic bifurcation are investigated by the variational equation and the rotated vector, respectively.",
        "keywords": [
            "State feedback control",
            " Periodic solution",
            " Bifurcation",
            " Perturbed system",
            " B-convergent",
            " Homoclinic cycle",
            " Rotated vector fields"
        ],
        "authors": [
            {
                "name": "Dandan\u00a0Fang",
                "org": "School of Science,Tianjin Polytechnic University,Tianjin,China"
            },
            {
                "name": "Yongzhen\u00a0Pei",
                "org": "School of Science,Tianjin Polytechnic University,Tianjin,China"
            },
            {
                "name": "Yunfei\u00a0Lv",
                "org": "School of Science,Tianjin Polytechnic University,Tianjin,China"
            },
            {
                "name": "Lansun\u00a0Chen",
                "org": "Academy of Mathematics and System Sciences,Chinese Academy of Sciences,Beijing,China"
            }
        ],
        "venue": "Nonlinear Dynamics",
        "year": 2017
    },
    "dK21LfpZ": {
        "id": "dK21LfpZ",
        "title": "Delayed stage-structured single-species model with disease in infant",
        "abstract": "A delayed stage-structured single-species model with disease in the infant is studied. By the method of eigenvalue for ordinary differential equation, and by the geometric figures, the sufficient and necessary conditions for the existence and stability of the three equilibrium points are got. In the inference, some thresholds for the parameter \u03c4 are found, which control the stability of the equilibrium points. When the parameter \u03c4 has different values, the corresponding stability property of the equilibrium points is obtained, and theoretical result is verified by a simple example. At last, the results from the viewpoint of biology are explained. If the delay is large enough and the maturation period is long enough, then the population will die out. If the delay is small and the maturation period is short, then the population may persist.",
        "keywords": [
            "Delay",
            "Equilibrium point",
            "Stage-structured"
        ],
        "authors": [
            {
                "name": "SHI Rui-qing",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            },
            {
                "name": "CHEN Lan-sun",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            }
        ],
        "venue": "Dalian Ligong Daxue Xuebao/Journal of Dalian University of Technology",
        "year": 2010
    },
    "Oy9Sevzz": {
        "id": "Oy9Sevzz",
        "title": "MODELING OF THE PREVENTION AND CONTROL OF FOREST PEST",
        "abstract": "",
        "keywords": [
            "boundary value problem",
            "forest pests",
            "impulses",
            "logistic equation"
        ],
        "authors": [
            {
                "name": "WEIJIAN XU",
                "org": ""
            },
            {
                "name": "SHIDONG CHEN",
                "org": ""
            },
            {
                "name": "LANSUN CHEN",
                "org": ""
            }
        ],
        "venue": "Journal of Biological Systems",
        "year": 2007
    },
    "nRTzAkmQ": {
        "id": "nRTzAkmQ",
        "title": "The effect of pulsed harvesting policy on the inshore-offshore fishery model with the impulsive diffusion",
        "abstract": "In this paper, we propose the inshore-offshore fishing model with impulsive diffusion and pulsed harvesting at the different fixed time. The existence and globally asymptotical stability of both the trivial periodic solution and the positive periodic solution are obtained. We show that the pulsed harvesting has a strong impact on the persistence of the fish population. By the numerical simulation, we obtain that the best time of fishing is at the end of the period \u03c4. \u00a9 2009 Springer Science+Business Media B.V.",
        "keywords": [
            "Globally asymptotical stability",
            "Impulsive diffusion",
            "Inshore-offshore model",
            "Periodic solution"
        ],
        "authors": [
            {
                "name": "Zhong Zhao",
                "org": "Huanghuai University(Huanghuai University),Zhumadian,China"
            },
            {
                "name": "Xuiquan Zhang",
                "org": "Huanghuai University(Huanghuai University),Zhumadian,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            }
        ],
        "venue": "Nonlinear Dynamics",
        "year": 2011
    },
    "zg3KAvPg": {
        "id": "zg3KAvPg",
        "title": "Impulsive vaccination of an SEIRS model with time delay and varying total population size.",
        "abstract": "Pulse vaccination is an effective and important strategy for the elimination of infectious diseases. A delayed SEIRS epidemic model with pulse vaccination and varying total population size is proposed in this paper. We point out, if R* < 1, the infectious population disappear so the disease dies out, while if R(*) > 1, the infectious population persist. Our results indicate that a long period of pulsing or a small pulse vaccination rate is sufficient condition for the permanence of the model.",
        "keywords": [
            "time delay \u00b7 pulse vaccination \u00b7 seirs epidemic model \u00b7 global attractivity \u00b7 permanence",
            "infectious disease",
            "epidemic model",
            "population size"
        ],
        "authors": [
            {
                "name": "Shujing Gao",
                "org": "Xinjiang University College of Mathematics and Systems Science Urumqi 830046 P.R. China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116024 P.R. China"
            },
            {
                "name": "Zhidong Teng",
                "org": "Xinjiang University College of Mathematics and Systems Science Urumqi 830046 P.R. China"
            }
        ],
        "venue": "Bulletin of mathematical biology",
        "year": 2007
    },
    "SgwLcgYP": {
        "id": "SgwLcgYP",
        "title": "Dynamic complexities of a Holling I predator\u2013prey model concerning periodic biological and chemical control",
        "abstract": "We investigate the dynamic behaviors of a Holling I predator\u2013prey model with impulsive effect concerning biological and chemical control strategy\u2013\u2013periodic releasing natural enemies and spraying pesticide at different fixed time. By using Floquet theorem and small amplitude perturbation method, we prove that there exists an asymptotically stable pest-eradication periodic solution when the impulsive period is less than some critical value. The condition for the permanence of the system is given. It is shown that our impulsive control strategy is more effective than the classical one if we take chemical control efficiently. Further, the effects of impulsive perturbations on the unforced continuous system is studied. We find that the system we considered has more complex dynamic behaviors and is dominated by periodic, quasi-periodic and chaotic solutions. We also find that our impulsive forced system may have different dynamic behaviors with different range of initial values, with which the solutions of the unforced system tend either to the inherent stable limit cycle or to a stable positive equilibrium.",
        "keywords": [
            "limit cycle",
            "critical value",
            "complex dynamics"
        ],
        "authors": [
            {
                "name": "Bing Liu",
                "org": ""
            },
            {
                "name": "Yujuan Zhang",
                "org": "Dalian University of Technology, Dalian 116024, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology, Dalian 116024, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2004
    },
    "JPmVSswQ": {
        "id": "JPmVSswQ",
        "title": "Profitless delays for permanence in a pure-delayed nonautonomous Lotka-Volterra competitive system with infinite delays and discrete delays",
        "abstract": "This paper studies a pure-delayed nonautonomous Lotka-Volterra competitive system with infinite delays and discrete delays. Sufficient conditions are obtained for the permanence of the system. The permanence of the system is dependent of time delays, that is, they are \"profitless\" delays because they have effect on the permanence of the system.",
        "keywords": [
            "time delay",
            "profitless delays",
            "competitive system",
            "volterra equations",
            "discrete delays",
            "paper study",
            "pure-delayed nonautonomous",
            "delays",
            "sufficient condition",
            "pure-delayed nonautonomous lotka-volterra competitive system",
            "profitless delay",
            "infinite delays",
            "infinite delay",
            "time delays",
            "discrete delay"
        ],
        "authors": [
            {
                "name": "Xinzhu Meng",
                "org": "Shandong University of Science and Technology, China"
            },
            {
                "name": "Huidong Cheng",
                "org": "Shandong University of Science and Technology, China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology, China"
            }
        ],
        "venue": "SNPD (1)",
        "year": 2007
    },
    "KM7EqJRs": {
        "id": "KM7EqJRs",
        "title": "Complex dynamics of Holling type II Lotka\u2013Volterra predator\u2013prey system with impulsive perturbations on the predator",
        "abstract": "This paper develops the Holling type II Lotka\u2013Volterra predator\u2013prey system, which may inherently oscillate, by introducing periodic constant impulsive immigration of predator. Condition for the system to be extinct is given and permanence condition is established via the method of comparison involving multiple Liapunov functions. Further influences of the impulsive perturbations on the inherent oscillation are studied numerically, which shows that with the increasing of the amount of the immigration, the system experiences process of quasi-periodic oscillating\u2192cycles\u2192periodic doubling cascade\u2192chaos\u2192periodic halfing cascade\u2192cycles, which is characterized by (1) quasi-periodic oscillating, (2) period doubling, (3) period halfing, (4) non-unique dynamics, meaning that several attractors coexist.",
        "keywords": [
            "oscillations",
            "complex dynamics"
        ],
        "authors": [
            {
                "name": "Xianning Liu",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Academia Sinica, Beijing 100080, China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2003
    },
    "bRUNd8I6": {
        "id": "bRUNd8I6",
        "title": "Impact of impulsive effect on a population dynamical behavior in a polluted environment",
        "abstract": "A mathematical model to study the effect of a toxicant impulsively emitted into the environment from external sources and toxin excreted by some factors on a single biological species, is proposed and analyzed. It is also assumed that the toxicant emission and toxin excretion are used in the same simultaneous periodicity. By using the comparative results of impulsive differential equations and some known results of a single species Logistic model, it is observed that the population is extinct on condition that the impulsive period is lower than some threshold value. When the impulsive period is higher than this critical value, the population is shown to be permanent. It is also proved that the permanent conditions assure that there exists a unique positive periodic solutions which is globally asymptotically stable.",
        "keywords": [
            "Extinction",
            "Globally asymptotically stable",
            "Impulse",
            "Periodic solutions",
            "Permanence",
            "Polluted environment"
        ],
        "authors": [
            {
                "name": "Hong Zhang",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            },
            {
                "name": "MENG Xin-zhu",
                "org": "Shandong University of Science and Technology(Shandong University of Science and Technology,Shandong Univ. of Sci. and Technol.),Qingdao,China"
            },
            {
                "name": "CHEN Lan-sun",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            }
        ],
        "venue": "Dalian Ligong Daxue Xuebao/Journal of Dalian University of Technology",
        "year": 2008
    },
    "7c6BGc8g": {
        "id": "7c6BGc8g",
        "title": "Optimal harvesting and stability for fishing models with stage structure in inshore-offshore areas",
        "abstract": "A fishing model with stage structure in inshore and offshore areas is considered. Steady states of the dynamical system representing\n fishery are derived and their local, as well as global, stability is discussed. The optimal harvest policy is formulated and\n solved as an optimal control problem. A numerical example is given to illustrate the solution procedure.",
        "keywords": [
            "34C25",
            "92D25",
            "34D20",
            "optimal harvest",
            "stage structure",
            "inshore-offshore area",
            "stability"
        ],
        "authors": [
            {
                "name": "Zhonghua Lu",
                "org": "Chinese Academy of Sciences Supercomputing Center of Computer Network Information Center 100080 Beijing China"
            },
            {
                "name": "Xuebin Chi",
                "org": "Chinese Academy of Sciences Supercomputing Center of Computer Network Information Center 100080 Beijing China"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics & System Sciences Institute of Mathematics 100080 Beijing China"
            }
        ],
        "venue": "Applied Mathematics-A Journal of Chinese Universities",
        "year": 2003
    },
    "NNv4tYNT": {
        "id": "NNv4tYNT",
        "title": "The effect of impulsive vaccination on an SIR epidemic model",
        "abstract": "In this paper, an SIR epidemic model is constructed and analyzed. We get the result that if the parameters satisfy the condition @b@a+@c+b, then the disease will be ultimately permanent. Under this condition, we consider how the impulsive vaccination affects the original system. The sufficient condition for the global asymptotical stability of the disease-eradication solution is obtained. We also get that if the impulsive vaccination rate is less than some value, the disease will be permanent, and the disease cannot be controlled. People can select appropriate vaccination rate according to our theoretical result to control diseases.",
        "keywords": [
            "disease-eradication periodic solution",
            "sir model",
            "epidemic",
            "impulsive",
            "satisfiability",
            "epidemic model"
        ],
        "authors": [
            {
                "name": "Ruiqing Shi",
                "org": ""
            },
            {
                "name": "Xiaowu Jiang",
                "org": "Department of Mathematics, Xinyang Normal University, Xinyang 464000, Henan, People\u2019s Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, People\u2019s Republic of China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2009
    },
    "AB53Dzya": {
        "id": "AB53Dzya",
        "title": "Hopf bifurcation of nonlinear incidence rates SIR epidemiological models with stage structure",
        "abstract": "",
        "keywords": [
            "disease-free equilibrium",
            "endemic equilibrium",
            "hopf bifurcation",
            "sir epidemiological model",
            "incidence rate"
        ],
        "authors": [
            {
                "name": "zhonghua lu",
                "org": "institute of mathematics"
            },
            {
                "name": "xianning liu",
                "org": "institute of mathematics"
            },
            {
                "name": "lansun chen",
                "org": "institute of mathematics"
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2001
    },
    "yRQk7FF6": {
        "id": "yRQk7FF6",
        "title": "Analysis of a stage-structured predatorprey system with birth pulse and impulsive harvesting at different moments",
        "abstract": "In this work, we consider a stage-structured predatorprey system with birth pulse and impulsive harvesting at different moments. Firstly, we prove that all solutions of the investigated system are uniformly ultimately bounded. Secondly, the conditions of the globally asymptotically stable prey-extinction boundary periodic solution of the investigated system are obtained. Thirdly, the permanence of the investigated system is also obtained. Finally, numerical analysis is inserted to illustrate the results. Our results provide reliable tactic basis for the practical biological economics management. \u00a9 2011 Elsevier Ltd. All rights reserved.",
        "keywords": [
            "Birth pulse",
            "Extinction",
            "Impulsive harvesting",
            "Permanence",
            "Predatorprey system"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": "Guizhou College of Finance and Economics(Guizhou College of Finance and Economics),Guiyang,China"
            },
            {
                "name": "Shaohong Cai",
                "org": "Guizhou College of Finance and Economics(Guizhou College of Finance and Economics),Guiyang,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and System Sciences Chinese Academy of Sciences(Chinese Academy of Sciences,Academy of Mathematics and Systems Science),Beijing,China"
            }
        ],
        "venue": "Nonlinear Analysis: Real World Applications",
        "year": 2011
    },
    "nZm8SRx9": {
        "id": "nZm8SRx9",
        "title": "Study of Lotka-volterra food chain chemostat with periodically varying dilution rate",
        "abstract": "In this paper, we introduce and study a model of Lotka-volterra chemostat food chain chemostat with periodically varying dilution\n rate, which contains with predator, prey, and substrate. We investigate the subsystem with substrate and prey and study the\n stability of the periodic solutions, which are the boundary periodic solutions of the system. The stability analysis of the\n boundary periodic solution yields an invasion threshold. By use of standard techniques of bifurcation theory, we prove that\n above this threshold there are periodic oscillations in substrate, prey, and predator. Simple cycles may give way to chaos\n in a cascade of period-doubling bifurcations. Furthermore, we numerically simulate a model with sinusoidal dilution rate,\n by comparing bifurcation diagrams with different bifurcation parameters, we can see that the system experiences following\n process: periodic solution \u2192 periodic doubling cascade \u2192 chaos.\n ",
        "keywords": [
            "bifurcation",
            "Lotka-volterra functional response",
            "chemostat",
            "periodic dilution",
            "chaos"
        ],
        "authors": [
            {
                "name": "Guoping Pang",
                "org": "Yulin Normal University Department of Mathematics and Computer Science Yulin, Guangxi 537000 People\u2019s Republic of China"
            },
            {
                "name": "Fengyan Wang",
                "org": "Jimei University College of Science Xiamen, Fujian 361021 People\u2019s Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian Liaoning 116024 People\u2019s Republic of China"
            }
        ],
        "venue": "Journal of Mathematical Chemistry",
        "year": 2008
    },
    "ztgl50Mp": {
        "id": "ztgl50Mp",
        "title": "Extinction and permanence in nonautonomous competitive system with stage structure",
        "abstract": "In this paper, the n -species nonautonomous stage-structured competitive system is constructed and considered. Sufficient conditions for its extinction and permanence are obtained. Results here generalize and unify some previous ones. Moreover, it is concluded that stage structure in this system is one of the important factors that effect the extinction and permanence of species.",
        "keywords": [
            "lotka\u2013volterra",
            "time delays",
            "stage structure",
            "nonautonomous",
            "competitive"
        ],
        "authors": [
            {
                "name": "Shengqiang Liu",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and System Sciences, Academia Sinica, Beijing 100080, PR China"
            },
            {
                "name": "Zhuojun Liu",
                "org": "Academy of Mathematics and System Sciences, Academia Sinica, Beijing 100080, PR China"
            }
        ],
        "venue": "Journal of Mathematical Analysis and Applications",
        "year": 2002
    },
    "irQCHIkG": {
        "id": "irQCHIkG",
        "title": "Studies on the dynamics of a continuous bioprocess with impulsive state feedback control",
        "abstract": "The oxygen demand in a bioreactor should be lower than the dissolved oxygen content. Biomass concentration is one of the most important factors which affect oxygen demand. Moreover, control of the medium substrate concentration is a result of the substrate inhibition phenomenon. Based on the design ideas of a continuous bioprocess which can regulate the biomass concentration, a mathematical model with the extended Monod growth kinetics and impulsive state feedback control is proposed in this paper. Through an analysis of the dynamic properties and a numerical simulation of the continuous bioprocess with impulsive state feedback control, the conditions are obtained for the existence and stability of the system\u2019s positive period-1 solution. It is also pointed out that the positive period-2 solution is non-existent. The results simplify the choosing of suitable operating conditions for continuous bioprocess. It also presents the complete expression of the positive period-1 solution period, which provides the precise feeding time frame for a regularly continuous bioprocess to achieve an equivalent stable output as that of an impulsive bioprocess in the same production environment. The article also presents and discusses aspects of the bioprocess optimization.",
        "keywords": [
            "State impulsive",
            "Feedback control",
            "Nonlinear biomass yield",
            "Periodic solution",
            "Optimization"
        ],
        "authors": [
            {
                "name": "Yuan Tian",
                "org": ""
            },
            {
                "name": "Kaibiao Sun",
                "org": "School of Electronic and Information Engineering, Dalian University of Technology, Dalian 116024, People\u2019s Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "School of Mathematical Science, Dalian University of Technology, Dalian 116024, People\u2019s Republic of China"
            },
            {
                "name": "Andrzej Kasperski",
                "org": "Faculty of Mathematics, Computer Science and Econometrics, Bioinformatics Factory, University of Zielona Gora, Szafrana 4a, 65-516 Zielona Gora, Poland"
            }
        ],
        "venue": "Chemical Engineering Journal",
        "year": 2010
    },
    "ADX2PNmX": {
        "id": "ADX2PNmX",
        "title": "Global qualitative analysis of new Monod type chemostat model with delayed growth response and pulsed input in polluted environment",
        "abstract": "In this paper, we consider a new Monod type chemostat model with time delay and impulsive input concentration of the nutrient\n in a polluted environment. Using the discrete dynamical system determined by the stroboscopic map, we obtain a \u201cmicroorganism-extinction\u201d\n periodic solution. Further, we establish the sufficient conditions for the global attractivity of the microorganism-extinction\n periodic solution. Using new computational techniques for impulsive and delayed differential equation, we prove that the system\n is permanent under appropriate conditions. Our results show that time delay is \u201cprofitless\u201d.",
        "keywords": [
            "chemostat model",
            "extinction",
            "time delay for growth response",
            "impulsive input",
            "permanence",
            "qualitative analysis",
            "delay differential equation"
        ],
        "authors": [
            {
                "name": "Xin-zhu Meng",
                "org": "Shandong University of Science and Technology College of Science Qingdao 266510 Shandong Province P. R. China"
            },
            {
                "name": "Qiu-lan Zhao",
                "org": "Shandong University of Science and Technology College of Science Qingdao 266510 Shandong Province P. R. China"
            },
            {
                "name": "Lan-sun Chen",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116024 Liaoning Province P. R. China"
            }
        ],
        "venue": "Applied Mathematics and Mechanics-english Edition",
        "year": 2008
    },
    "2FsuARhE": {
        "id": "2FsuARhE",
        "title": "Periodic solutions of a discrete time Lotka-Volterra type food-chain model with delays",
        "abstract": "A periodic discrete time three trophic level Lotka-Volterra type food-chain model is investigated. By using Gaines and Mawhin's continuation theorem of coincidence degree theory, sufficient conditions are derived for the existence of positive periodic solutions of the model.",
        "keywords": [
            "food-chain model",
            "sufficient condition",
            "coincidence degree theory",
            "trophic level lotka-volterra type",
            "positive periodic solution",
            "discrete time lotka-volterra type",
            "continuation theorem",
            "periodic solution",
            "periodic discrete time",
            "coincidence degree",
            "discrete time",
            "food chain",
            "trophic level"
        ],
        "authors": [
            {
                "name": "Rui Xu",
                "org": "Department of Mathematics, Institute of Shijiazhuang Mechanical Engineering, 97 Heping West Road, Shijiazhuang 050003, Hebei Province, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Science, Academia Sinica, Beijing, 100080, PR China"
            },
            {
                "name": "Feilong Hao",
                "org": "Department of Mathematics, Institute of Shijiazhuang Mechanical Engineering, 97 Heping West Road, Shijiazhuang 050003, Hebei Province, PR China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2005
    },
    "2OjO9hkB": {
        "id": "2OjO9hkB",
        "title": "Global behaviors of a generalized periodic impulsive Logistic system with nonlinear density dependence",
        "abstract": "",
        "keywords": [
            "global attractor",
            "impulse",
            "logistic system",
            "periodic solution",
            "density dependence"
        ],
        "authors": [
            {
                "name": "xianning liu",
                "org": ""
            },
            {
                "name": "lansun chen",
                "org": "institute of mathematics"
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2005
    },
    "DX1AdunQ": {
        "id": "DX1AdunQ",
        "title": "Optimal harvesting policy for inshore-offshore fishery model with impulsive diffusion*",
        "abstract": "This article studies the inshore-offshore fishery model with impulsive diffusion. The existence and global asymptotic stability of both the trivial periodic solution and the positive periodic solution are obtained. The complexity of this system is also analyzed. Moreover, the optimal harvesting policy are given for the inshore subpopulation, which includes the maximum sustainable yield and the corresponding harvesting effort.",
        "keywords": [
            "periodic solution",
            "inshore-offshore fishery model",
            "impulsive diffusion",
            "optimal harvesting policy",
            "global asymptotic stability"
        ],
        "authors": [
            {
                "name": "Lingzhen Dong",
                "org": "Department of Mathematics, Taiyuan University of Technology, Taiyuan 030024, China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116023, China"
            },
            {
                "name": "Lihua Sun",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116023, China"
            }
        ],
        "venue": "\u6570\u5b66\u7269\u7406\u5b66\u62a5(\u82f1\u6587\u7248)",
        "year": 2007
    },
    "uiYBkROz": {
        "id": "uiYBkROz",
        "title": "Analysis of a viral disease model with saturated contact rate",
        "abstract": "A viral disease model with saturated contact rate is introduced and investigated. The model consists a host species, which is divided into two classes the susceptible and infected, and a virus, which causes a viral disease in the host and as the host induces, the infected releases more virus into the environment. Taking the virus replication rate as the bifurcating parameter, we prove that there exists a threshold value beyond which the endemic equilibrium bifurcates from the free disease one. Further increasing the value, the endemic equilibrium loses its stability, Hopf bifurcation occurs and a periodic solution arises from it. The orbital stability of the periodic orbits is analyzed by applying Poore\u2019s condition. In the last, numerical simulation of the model is employed to explain the mathematical results of this paper.",
        "keywords": [
            "hopf bifurcation",
            "numerical simulation"
        ],
        "authors": [
            {
                "name": "Guoping Pang",
                "org": ""
            },
            {
                "name": "Fengyan Wang",
                "org": "College of Science, Jimei University, Xiamen Fujian 361021, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian Liaoning 116024, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2009
    },
    "14h5V7zc": {
        "id": "14h5V7zc",
        "title": "Integrated pest management models and their dynamical behaviour.",
        "abstract": "Two impulsive models of integrated pest management (IPM) strategies are proposed, one with fixed intervention times and the other with these unfixed. The first model allows natural enemies to survive but under some conditions may lead to extinction of the pest. We use a simple prey-dependent consumption model with fixed impulsive effects and show that there exists a globally stable pest-eradication periodic solution when the impulsive period is less than certain critical values. The effects of pest resistance to pesticides are also studied. The second model is constructed in the light of IPM practice such that when the pest population reaches the economic injury level (EIL), a combination of biological, cultural, and chemical tactics that reduce pests to tolerable levels is invoked. Using analytical methods, we show that there exists an orbitally asymptotically stable periodic solution with a maximum value no larger than the given Economic Threshold (ET). The complete expression for this periodic solution is given and the ET is evaluated for given parameters. We also show that in some cases control costs can be reduced by replacing IPM interventions at unfixed times with periodic interventions. Further, we show that small perturbations of the system do not affect the existence and stability of the periodic solution. Thus, we provide the first demonstration using mathematical models that an IPM strategy is more effective than classical control methods.",
        "keywords": [
            "Periodic Solution",
            "Natural Enemy",
            "Mathematical Biology",
            "Integrate Pest Management",
            "Pest Population"
        ],
        "authors": [
            {
                "name": "Sanyi Tang",
                "org": ""
            },
            {
                "name": "Yanni Xiao",
                "org": "Department of Mathematical Sciences, The University of Liverpool, Liverpool L69 3BX, UK"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and System Sciences, Chinese Academy of Sciences, Beijing 100080, PR China"
            },
            {
                "name": "Robert A Cheke",
                "org": "Natural Resources Institute, University of Greenwich, Central Avenue, Chatham Maritime, Chatham, Kent ME4 4TB, UK"
            }
        ],
        "venue": "Bulletin of mathematical biology",
        "year": 2005
    },
    "tCCqsqCP": {
        "id": "tCCqsqCP",
        "title": "The dynamics of a new SIR epidemic model concerning pulse vaccination strategy",
        "abstract": "A new SIR epidemic model with vertical and horizontal transmission is proposed, and the dynamics of this disease model under constant and pulse vaccination are analyzed. Firstly, global stability of the endemic equilibrium states of the model with constant vaccination is thereby established. Further, we show that there exists a stable \u2018infection-free\u2019 periodic solution when the period of impulsive effect is less than some critical value. The condition for the permanence of the system with pulse vaccination is also given, which implies the periodic bursts of epidemic occurs. Numerical simulation shows system with pulse vaccination has more complex dynamic behavior for positive periodic oscillation, \u2018infection free\u2019 quasi-periodic oscillation than system with constant vaccination. Finally, we compare validity of the strategy of pulse vaccination with no vaccination and constant vaccination, and conclude that pulse vaccination strategy is more effective than no vaccination and continuous vaccination.",
        "keywords": [
            "permanence",
            "vertical transmission",
            "pulse vaccination",
            "periodic solution",
            "oscillations",
            "critical value",
            "numerical simulation",
            "epidemic model",
            "complex dynamics"
        ],
        "authors": [
            {
                "name": "Xinzhu Meng",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Academia Sinica, Beijing 100080, PR China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2008
    },
    "776v09u8": {
        "id": "776v09u8",
        "title": "Chaotic Behavior of a Periodically Forced predator-prey System with Beddington-Deangelis Functional Response and impulsive Perturbations",
        "abstract": "",
        "keywords": [
            "bifurcation",
            "chaos",
            "complexity",
            "impulsive perturbation",
            "periodic forcing",
            "predator-prey system",
            "bifurcation diagram",
            "functional response",
            "complex dynamics"
        ],
        "authors": [
            {
                "name": "Shuwen Zhang",
                "org": ""
            },
            {
                "name": "Dejun Tan",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Advances in Complex Systems",
        "year": 2006
    },
    "Ax52wLfn": {
        "id": "Ax52wLfn",
        "title": "A novel method for analyzing the stability of periodic solution of impulsive state feedback model",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Mingjing Sun",
                "org": ""
            },
            {
                "name": "Yinli Liu",
                "org": ""
            },
            {
                "name": "Sujuan Liu",
                "org": ""
            },
            {
                "name": "Zuoliang Hu",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2016
    },
    "qUfcG7UO": {
        "id": "qUfcG7UO",
        "title": "A Stage Structure Predator-prey Model with Infectious Disease in the Prey",
        "abstract": "A stage structure impulsive delayed predator-prey model with infectious disease in the prey was considered.The sufficient conditions for the global attractivity of susceptible pest-eradication periodic solution were obtained by using corresponding theories and methods of impulsive delayed differential equation.Furthermore,it was obtained that the susceptible pest population can be controlled under the economic injury level E(EIL)if the impulsive period was within an appropriate range,that is,the susceptible pest population and natural enemy population may coexist.Our results provided reliable tactic basis for the practical pest management.",
        "keywords": [
            "pest management",
            "stage-structure",
            "impulsive",
            "time delay",
            "global attractivity"
        ],
        "authors": [
            {
                "name": "Wei Chunjin",
                "org": "School of Science,Jimei University,Xiamen Fujian ;Department of Applied Mathematics,Dalian University of Technology,Dalian Liaoning "
            },
            {
                "name": "Chen Lansun",
                "org": "Department of Applied Mathematics,Dalian University of Technology,Dalian Liaoning "
            }
        ],
        "venue": "Journal of Mathematical Study",
        "year": 2008
    },
    "eDYJx6QG": {
        "id": "eDYJx6QG",
        "title": "An impulsive predator\u2013prey model with disease in the prey for integrated pest management",
        "abstract": "",
        "keywords": [
            "impulsive",
            "permanent",
            "predator-prey model",
            "susceptible pest-eradication periodic solution",
            "integrated pest management",
            "satisfiability"
        ],
        "authors": [
            {
                "name": "Ruiqing Shi",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2010
    },
    "ZWW0flfa": {
        "id": "ZWW0flfa",
        "title": "Existence of positive periodic solution of an impulsive delay Logistic model",
        "abstract": "In this paper, we use the continuation theory for k -set contractions to study the existence of positive periodic solutions of the impulsive delay Logistic model x \u2032 ( t ) = r ( t ) x ( t ) 1 - x ( t - \u03c4 ) K ( t ) , t \u2260 t k , x ( t k + ) - x ( t k ) = b k x ( t k ) , k = 1 , 2 , \u2026 The sufficient conditions of the existence of positive periodic solution are obtained. Keywords Impulsive delay model k -Set contractions Jump condition Existence Periodic solution",
        "keywords": [
            "existence",
            "impulsive delay model",
            "jump condition",
            "k-set contractions",
            "periodic solution",
            "logistic model"
        ],
        "authors": [
            {
                "name": "Shulin Sun",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Liaoning, Dalian 116024, PR China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2007
    },
    "M0ZWU0vS": {
        "id": "M0ZWU0vS",
        "title": "Impulsive perturbations of a predator-prey system with\u00a0modified Leslie-Gower and Holling type II schemes",
        "abstract": "In this paper, the dynamics of an impulsively controlled predator-prey model with modified Leslie-Gower and Holling type II\n schemes is analyzed. Choosing pest birth rate r\n 1 as control parameter, we show that there exists a globally asymptotically stable pest-eradication periodic solution when\n r\n 1 is less than some critical value \n  \n and the system is permanent when r\n 1 is larger than the critical value \n  \n By use of standard techniques of bifurcation theory, we prove that this threshold there are periodic oscillations in pest\n and predator. Furthermore, some situations which leads to chaotic behavior of the system are investigated by means of numerical\n simulations.",
        "keywords": [
            "periodic solution \u00b7 extinction \u00b7 permanence \u00b7 bifurcation \u00b7 chaos"
        ],
        "authors": [
            {
                "name": "Zhong Zhao",
                "org": "Department of Mathematics, Huanghuai University, Zhumadian, 463000 Henan P.R. China"
            },
            {
                "name": "Li Yang",
                "org": "Department of Mathematics, Huanghuai University, Zhumadian, 463000 Henan P.R. China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian, 116024 P.R. China"
            }
        ],
        "venue": "",
        "year": 2011
    },
    "s8VZ6bLi": {
        "id": "s8VZ6bLi",
        "title": "WITHDRAWN: < Qualitative analysis of a variable yield chemostat with impulsive state feedback control>",
        "abstract": "This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy .",
        "keywords": [],
        "authors": [
            {
                "name": "Hongjian Guo",
                "org": "College of Mathematics and Information Science, Xinyang Normal University, Xinyang 464000, P.R. China"
            },
            {
                "name": "Lansun Chen",
                "org": "School of Mathematical Sciences, Dalian University of Technology, Dalian 116024, P.R. China"
            }
        ],
        "venue": "Mathematics and Computers in Simulation",
        "year": 2009
    },
    "w4JbvoqG": {
        "id": "w4JbvoqG",
        "title": "Dynamic Analysis of a Predator-Prey (Pest) Model with Disease in Prey and Involving an Impulsive Control Strategy.",
        "abstract": "The dynamic behaviors of a predator-prey (pest) model with disease in prey and involving an impulsive control strategy to release infected prey at fixed times are investigated for the purpose of integrated pest management. Mathematical theoretical works have been pursuing the investigation of the local asymptotical stability and global attractivity for the semitrivial periodic solution and population persistent, which depicts the threshold expression of some critical parameters for carrying out integrated pest management. Numerical analysis indicates that the impulsive control strategy has a strong effect on the dynamical complexity and population persistent using bifurcation diagrams and power spectra diagrams. These results show that if the release amount of infective prey can satisfy some critical conditions, then all biological populations will coexist. All these results are expected to be of use in the study of the dynamic complexity of ecosystems. \u00a9 2012 Min Zhao et al.",
        "keywords": [],
        "authors": [
            {
                "name": "Min Zhao",
                "org": ""
            },
            {
                "name": "Yanzhen Wang",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "J. Applied Mathematics",
        "year": 2012
    },
    "iJscMT5B": {
        "id": "iJscMT5B",
        "title": "Permanence and Extinction in Logistic and Lotka\u2013Volterra Systems with Diffusion",
        "abstract": "In this paper we consider the effect of diffusion on the permanence and extinction of single and multiple endangered species that live in changing patch environments. Differing from former studies, our discussion includes the important situation in conservation biology in which species live in a weak patchy environment, in the sense that species will become extinct in some of the isolated patches. For the single population model, we show that identical species can persist for some diffusion rates and can also vanish for another set of restrictions on the diffusion rates, although the single endangered species will vanish in some isolated patches without contributions from other patches. Furthermore, we consider the existence, uniqueness, and global stability of the positive periodic solution. For prey\u2013predator systems we can make both the prey and the predator species permanent by choosing the diffusion rates appropriately, even if the prey species has a negative intrinsic growth rate in some patches. Moreover, we introduce an exotic competitive species y into the habitat occupied by the native species x . Competitive permanence and competitive exclusion both are considered. The implications of these results are significant for the conservation of endangered species.",
        "keywords": [
            "periodic solution",
            "diffusion",
            "logistic equation",
            "lotka\u2013volterra system",
            "stability",
            "extinction",
            "permanence",
            "endangered species",
            "native species",
            "differential equation",
            "population model",
            "competitive exclusion",
            "population dynamics",
            "diffusion equation",
            "conservation biology"
        ],
        "authors": [
            {
                "name": "Jingan Cui",
                "org": "Department of Mathematics, Nanjing Normal University, Nanjing, 210097, China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and Systems Sciences, Chinese Academy of Sciences, Beijing, 100080, China"
            }
        ],
        "venue": "Journal of Mathematical Analysis and Applications",
        "year": 2001
    },
    "yq4DGWjF": {
        "id": "yq4DGWjF",
        "title": "Periodic solution of a turbidostat system with impulsive state feedback control",
        "abstract": "A turbidostat is an apparatus used to continuously culturing microorganisms. The concentration of the microorganism in the\n turbidostat can be controlled by the photoelectricity system or other devices. When the concentration of the microorganism\n is lower than a critical level, the dilution rate keeps constant. Once the concentration reaches the critical level, the dilution\n rate can be increased by the control of the photoelectricity system. Based on the design ideas of the turbidostat, a differential\n equation with impulsive state feedback control, which has no explicit solutions, is proposed for the turbidostat system. By\n the existence criteria of periodic solution of a general planar impulsive autonomous system, the conditions for the existence\n of an order one periodic solution of the system are obtained. Furthermore, it is pointed out that the system either tends\n to a stable state or has a periodic solution. Finally, some discussions and numerical simulations are given.",
        "keywords": [
            "Turbidostat",
            "Microorganism",
            "Continuous culture",
            "Impulsive control",
            "Periodic solution"
        ],
        "authors": [
            {
                "name": "Hongjian Guo",
                "org": "Xinyang Normal University Department of Mathematics Xinyang 464000 People\u2019s Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116024 People\u2019s Republic of China"
            }
        ],
        "venue": "Journal of Mathematical Chemistry",
        "year": 2009
    },
    "EFbFLLNE": {
        "id": "EFbFLLNE",
        "title": "AN IMPULSIVE PREDATOR-PREY SYSTEM WITH BEDDINGTON\u2013DEANGELIS FUNCTIONAL RESPONSE AND TIME DELAY",
        "abstract": "",
        "keywords": [
            "beddington-deangelis functional response",
            "impulsive perturbation",
            "maturation delay",
            "predator-prey system",
            "stage structure",
            "functional response"
        ],
        "authors": [
            {
                "name": "HONG ZHANG",
                "org": ""
            },
            {
                "name": "PAUL GEORGESCU",
                "org": ""
            },
            {
                "name": "LANSUN CHEN",
                "org": ""
            }
        ],
        "venue": "International Journal of Biomathematics",
        "year": 2008
    },
    "rHLRFFWf": {
        "id": "rHLRFFWf",
        "title": "Effect of rhizosphere dispersal and impulsive input on the growth of wetland plant.",
        "abstract": "Abstract   Modeling the wetland plant\u2013nutrient interaction is significant for elucidating the complex mechanisms of the nutrient absorption. In this paper, the effect of pollutant dispersal and impulsive input on the growth of wetland plant is presented. By using the theory of impulsive differential equations, we obtain that the wetland plant-eradication periodic solution is globally asymptotically stable if some conditions are satisfied. In addition, the permanent conditions are given by means of the comparison theorem of impulsive differential equations. Finally, numerical simulations are given to justify our results.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhong Zhao",
                "org": "School of Mathematics and Statistics, Huanghuai University, Zhumadian 463000, Henan, PR China"
            },
            {
                "name": "Qiuying Li",
                "org": "School of Mathematics and Statistics, Huanghuai University, Zhumadian 463000, Henan, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100080, PR China"
            }
        ],
        "venue": "Mathematics and Computers in Simulation",
        "year": 2018
    },
    "KzHpJpee": {
        "id": "KzHpJpee",
        "title": "Three kinds of TVS in a SIR epidemic model with saturated infectious force and vertical transmission",
        "abstract": "Three different vaccination and treatment strategies in the SIR epidemic model with saturated infectious force and vertical transmission are analyzed. The dynamics of epidemic models are globally investigated by using Floquet theory and comparison theorem of impulsive differential equation. Thresholds are identified and global stability results are proved. For every treatment and vaccination strategy, the disease-free periodic solution of impulsive system has been obtained and is found to be globally asymptotically stable when the basic reproduction number is less than one, equivalently the cure rate is larger than the threshold value, whereas the disease is persistent when the basic reproduction number is larger than one. These results indicate that a large cure rate will lead to the eradication of a disease.",
        "keywords": [
            "Global stability",
            "Pulse",
            "Persistent",
            "Treatment",
            "Vaccination"
        ],
        "authors": [
            {
                "name": "Shaoying Liu",
                "org": "School of Science, Tianjin Polytechnic University, Tianjin 3001610 China"
            },
            {
                "name": "Yongzhen Pei",
                "org": ""
            },
            {
                "name": "Changguo Li",
                "org": "Department of Basic Science, Institute of Military Traffic, Tianjin 300161, China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, 116023, China"
            }
        ],
        "venue": "Applied Mathematical Modelling",
        "year": 2009
    },
    "BNzRgw2N": {
        "id": "BNzRgw2N",
        "title": "Toxic action and antibiotic in the chemostat: permanence and extinction of a model with functional response",
        "abstract": "A system of periodic coefficients functional differential equations is used to model the single microorganism in the chemostat\n environment with a periodic nutrient and antibiotic input. Furthermore, the total toxic action on the microorganism expressed\n by an integral term is considered in our system. Based on the technique of analysis, we obtain sufficient conditions which\n guarantee the permanence of the system and extinction of the microorganism.\n ",
        "keywords": [
            "extinction",
            "functional differential equation",
            "antibiotic",
            "permanence",
            "toxic action",
            "functional response"
        ],
        "authors": [
            {
                "name": "Hong Zhang",
                "org": "Jiangsu University Department of Mathematics Zhenjiang, Jiangsu 212013 People\u2019s Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116024 People\u2019s Republic of China"
            }
        ],
        "venue": "Journal of Mathematical Chemistry",
        "year": 2008
    },
    "ZGsCUvfJ": {
        "id": "ZGsCUvfJ",
        "title": "A study of predator\u2013prey models with the Beddington\u2013DeAnglis functional response and impulsive effect",
        "abstract": "In this paper, the predator\u2013prey system with the Beddington\u2013DeAngelis functional response is developed, by introducing a proportional periodic impulsive catching or poisoning for the prey populations and a constant periodic releasing for the predator. The Beddington\u2013DeAngelis functional response is similar to the Holling type II functional response but contains an extra term describing mutual interference by predators. This model has the potential to protect predator from extinction, but under some conditions may also lead to extinction of the prey. That is, the system exists a locally stable prey-eradication periodic solution when the impulsive period satisfies an inequality. The condition for permanence is established via the method of comparison involving multiple Liapunov\u0300 functions. Further, by numerical simulation method the influences of the impulsive perturbations and mutual interference by predators on the inherent oscillation are investigated. With the increasing of releasing for the predator, the system appears a series of complex phenomenon, which include (1) period-doubling, (2) chaos attractor, (3) period-halfing. (4) non-unique dynamics (meaning that several attractors coexist).",
        "keywords": [
            "oscillations",
            "numerical simulation",
            "satisfiability",
            "functional response"
        ],
        "authors": [
            {
                "name": "Shuwen Zhang",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Liaoning, Dalian 116024, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2006
    },
    "NM9n5yJX": {
        "id": "NM9n5yJX",
        "title": "Analysis of a predator-prey model with predators impulsively diffusing between two patches",
        "abstract": "",
        "keywords": [
            "Extinction",
            "Impulsive diffusion",
            "Permanence",
            "Predator-prey model"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": "Simulation(Simulation),Guiyang,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and System Sciences Chinese Academy of Sciences(Chinese Academy of Sciences,Academy of Mathematics and Systems Science),Beijing,China"
            }
        ],
        "venue": "Discrete and Continuous Dynamical Systems - Series B",
        "year": 2010
    },
    "DS5oah6q": {
        "id": "DS5oah6q",
        "title": "Periodic solution and almost periodic solution for a nonautonomous Lotka\u2013Volterra dispersal system with infinite delay",
        "abstract": "This paper studies a nonautonomous Lotka\u2013Volterra dispersal systems with infinite time delay which models the diffusion of a single species into n patches by discrete dispersal. Our results show that the system is uniformly persistent under an appropriate condition. The sufficient condition for the global asymptotical stability of the system is also given. By using Mawhin continuation theorem of coincidence degree, we prove that the periodic system has at least one positive periodic solution, further, obtain the uniqueness and globally asymptotical stability for periodic system. By using functional hull theory and directly analyzing the right functional of almost periodic system, we show that the almost periodic system has a unique globally asymptotical stable positive almost periodic solution. We also show that the delays have very important effects on the dynamic behaviors of the system.",
        "keywords": [
            "time delay",
            "asymptotic stability",
            "hull equation",
            "dispersal",
            "periodic solution and almost periodic solution"
        ],
        "authors": [
            {
                "name": "Xinzhu Meng",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Academia Sinica, Beijing 100080, PR China"
            }
        ],
        "venue": "Journal of Mathematical Analysis and Applications",
        "year": 2008
    },
    "5o4kAmjs": {
        "id": "5o4kAmjs",
        "title": "A Stage-Structured SI Eco-Epidemiological Model with Time Delay and Impulsive Controlling.",
        "abstract": "This paper formulates a robust stage-structured SI eco-epidemiological model with periodic constant pulse releasing of infectious\n pests with pathogens. The authors show that the conditions for global attractivity of the \u2018pest-eradication\u2019 periodic solution\n and permanence of the system depend on time delay, hence, the authors call it \u201cprofitless\u201d. Further, the authors present a\n pest management strategy in which the pest population is kept under the economic threshold level (ETL) when the pest population\n is uniformly persistent. By numerical analysis, the authors also show that constant maturation time delay for the susceptible\n pests and pulse releasing of the infectious pests can bring obvious effects on the dynamics of system.",
        "keywords": [
            "permanence",
            "pest management",
            "stage-structured si infectious disease model.",
            "impulsive effects",
            "maturation time delay",
            "numerical analysis",
            "infectious disease"
        ],
        "authors": [
            {
                "name": "Xinzhu Meng",
                "org": "Shandong University of Science and Technology College of Science Qingdao 266510 China"
            },
            {
                "name": "Lansun Chen",
                "org": "Chinese Academy of Sciences Institute of Mathematics, Academy of Mathematics and Systems Science Beijing 100190 China"
            }
        ],
        "venue": "J. Systems Science & Complexity",
        "year": 2008
    },
    "hfcPaBnm": {
        "id": "hfcPaBnm",
        "title": "A pest management SI model with periodic biological and chemical control concern",
        "abstract": "In this work, we consider an SI model for pest management, with concerns about impulsive releases of infective pests and pesticides sprays. We prove that all solutions of (I) S \u2032 ( t ) = rS ( t ) 1 - S ( t ) + \u03b8 I ( t ) K - \u03b2 S ( t ) I 2 ( t ) , t \u2260 n \u03c4 , I \u2032 ( t ) = \u03b2 S ( t ) I 2 ( t ) - wI ( t ) , t \u2260 n \u03c4 , \u0394 S ( t ) = - \u03bc 1 S ( t ) , t = n \u03c4 , \u0394 I ( t ) = - \u03bc 2 I ( t ) + \u03bc , t = n \u03c4 , n = 1 , 2 , \u2026 , are uniformly ultimately bounded and there exists globally asymptotic stability periodic solution of pest-extinction when ln 1 1 - \u03bc 1 > r \u03c4 - r \u03bc \u03b8 ( 1 - exp ( - w \u03c4 ) ) Kw ( 1 - ( 1 - \u03bc 2 ) exp ( - w \u03c4 ) ) - \u03b2 \u03bc 2 ( 1 - exp ( - 2 w \u03c4 ) ) 2 w ( 1 - ( 1 - \u03bc 2 ) exp ( - w \u03c4 ) ) 2 is satisfied, and the condition for permanence of system (I) is also obtained. It is concluded that the approach of combining impulsive infective releasing with impulsive pesticide spraying provides reliable tactic basis for practical pest management. Keywords Impulsive Infective Chemical control Pest- extinction 1 Introduction According to reports of the Food and Agriculture Organization, the warfare between man and pests has sustained for thousands of years. With the development of society and progress of science and technology, human have adopted some advanced and modern weapons, for instance chemical pesticides, biological pesticides, remote sensing and measure, computers, atomic energy etc., where some brilliant achievements have been obtained. However, the warfare is not over, and will continue. A great deal of and a large variety of pesticides were used to control pests. In all, pesticides are useful because they can quickly kill a significant portion of a pest population and sometimes provide the only feasible method for preventing economic loss. However, pesticide pollution is also recognized as a major health hazard to human beings and beneficial insects. Lengthening the period of pesticides spraying may reduce the cost of pest management. In this paper, a good approach is given which combines pesticides efficacy tests with biological research. The use of bacteria, fungi and viruses is potentially one of the most important approaches in pest control. For example, Bacillus thuringiensis , which is available in commercial preparations, is used in the control of a large number of pests [1\u20133,8,9] . An advantage of using insect pathogens is that they are safe to man and are usually safe to beneficial insects. There is a vast amount of literature on the applications of microbial disease to suppress pests [3,4,7,9,10] and many good articles [15\u201325] devote to disease transmission, but there are a few papers on a mathematical model of the dynamical of microbial disease in pest control [5,6,11,31] . In this paper, we will introduce additional infective pests, which are obtained in the laboratory, into a natural SI system with spaying pesticides for pest control. We shall examine the strategy of combining periodic releasing of infective pests with periodic spraying of pesticides in a more flexible manner. 2 Model formulation The basic SI model is (2.1) S \u2032 ( t ) = - \u03b2 S ( t ) I ( t ) , I \u2032 ( t ) = \u03b2 S ( t ) I ( t ) - wI ( t ) , where \u03b2 > 0 is called the transmission coefficient, w > 0 is called the death coefficient of I ( t ), S ( t ) denotes the number of susceptible insects and I ( t ) denotes the number of infective insects. In our models we assume that all newborns are susceptible, and the basic model considered in [12] follows a model of the epidemic under a control variable: (2.2) S \u2032 ( t ) = - \u03b2 S ( t ) I ( t ) , I \u2032 ( t ) = \u03b2 S ( t ) I ( t ) - wI ( t ) + u ( t ) , where u ( t ), which is a control variable, denotes the rate of pests infected in the laboratory, and there are some other conditions for the above system, but we consider that the variable u ( t ) is difficult in practice. And the susceptible pests S ( t ) will not go to extinction with regard to human beings and some mass residing animals, Anderson et al. pointed out that standard incidence is more suitable than bilinear incidence [26\u201328] . Levin et al. have adopted a incidence form like \u03b2S q I p or \u03b2 S q I p N which depends on different infective diseases and environments [29,30] . So we develop (2.2) by introducing a constant periodic releasing of the infective pests and spaying pesticides at a fixed moment, that is, we consider the following impulsive differential equation with a fixed moment: (2.3) S \u2032 ( t ) = rS ( t ) 1 - S ( t ) + \u03b8 I ( t ) K - \u03b2 S ( t ) I 2 ( t ) , t \u2260 n \u03c4 , I \u2032 ( t ) = \u03b2 S ( t ) I 2 ( t ) - wI ( t ) , t \u2260 n \u03c4 , \u0394 S ( t ) = - \u03bc 1 S ( t ) , t = n \u03c4 , \u0394 I ( t ) = - \u03bc 2 I ( t ) + \u03bc , t = n \u03c4 , n = 1 , 2 , \u2026 , where r > 0 is the intrinsic growth rate of pests, K > 0 is the pests capacity of environment, \u0394 I ( t ) = I ( t + ) \u2212 I ( t ), 0 < \u03b8 < 1, \u03bc \u2a7e 0 is the released amount of infective pests at t = n\u03c4 , n \u2208 Z + , 1 > \u03bc 1 \u2a7e 0, 1 > \u03bc 2 \u2a7e 0 respectively, which represents the portion of susceptible and infective pests due to spraying pesticides at t = n\u03c4 , n \u2208 Z + and Z + = {1, 2, \u2026}, \u03c4 is the period of the impulsive effect, that is, we can use a combination of biological and chemical tactics to eradicate pests or keep the pest population below the damage level. 3 Qualitative analysis for model (2.3) The solution of (2.3) , denote by x ( t ) = ( S ( t ), I ( t )) T , is a piecewise continuous function x : R + \u2192 R + 2 , x ( t ) is continuous on ( n\u03c4 , ( n + 1) \u03c4 ], n \u2208 Z + and x ( n \u03c4 + ) = lim t \u2192 n \u03c4 + x ( t ) exists. Obviously the global existence and uniqueness of solutions of (2.3) is guaranteed by the smoothness properties of f , which denote the mapping defined by the right-side of system (2.3) (see [13] ). Before we state the main results, we need to give some lemmas which will be used in the next section. Since ( S \u2032( t ) = 0 whenever S ( t ) = 0, I \u2032( t ) = 0 whenever I ( t ) = 0, t \u2260 n\u03c4 , and I ( n\u03c4 + ) = I ( n\u03c4 ) + \u03bc , \u03bc \u2a7e 0. So we have Lemma\u00a01 Suppose x(t) is a solution of ( 2.3 ) with x(0 + ) \u2a7e 0, then x(t) \u2a7e 0 for t \u2a7e 0, and further x(t) > 0, t \u2a7e 0 for x(0 + ) > 0. Lemma\u00a02 see [13, p. 23, Lemma 2.2] Let the function m \u2208 PC \u2032 [R + , R] satisfies the inequalities (3.1) m \u2032 ( t ) \u2a7d p ( t ) m ( t ) + q ( t ) , t \u2a7e t 0 , t \u2260 t k , k = 1 , 2 , \u2026 , m ( t k + ) \u2a7d d k m ( t k ) ) + b k , t = t k , where p, q \u2208 PC[R + , R] and d k \u2a7e 0, b k are constants, then m ( t ) \u2a7d m ( t 0 ) \u220f t 0 < t k < t d k exp \u222b t 0 t p ( s ) d s + \u2211 t 0 < t k < t \u220f t k < t j < t d j exp \u222b t 0 t p ( s ) d s b k + \u222b t 0 t \u220f s < t k < t d k exp \u222b s t p ( \u03c3 ) d \u03c3 q ( s ) d s , t \u2a7e t 0 . Now, we show that all solutions of (2.3) are uniformly ultimately bounded. Lemma\u00a03 There exists a constant M > 0 such that S(t) \u2a7d M, I(t) \u2a7d M for each solution (S(t), I(t)) of ( 2.3 ) with all t large enough. Proof Define V ( t ) = S ( t ) + I ( t ), then t \u2260 n\u03c4 . We have D + V ( t ) + wV ( t ) = ( r + w ) S ( t ) - rS 2 ( t ) K - r \u03b8 S ( t ) I ( t ) K \u2a7d ( r + w ) S ( t ) - rS 2 ( t ) K \u2a7d M 0 , where M 0 = K ( r + w ) 2 4 r , when t = n\u03c4 , V ( n\u03c4 + ) = (1 \u2212 \u03bc 1 ) S ( n\u03c4 ) + (1 \u2212 \u03bc 2 ) I ( n\u03c4 ) + \u03bc \u2a7d V ( n\u03c4 ) + \u03bc . By Lemma 2 , for t \u2208 ( n\u03c4 , ( n + 1) \u03c4 ], we have V ( t ) \u2a7d V ( 0 ) exp ( - wt ) + \u222b 0 t M 0 exp ( - w ( t - s ) ) d s + \u2211 0 < n \u03c4 < t \u03bc exp ( - w ( t - n \u03c4 ) ) = V ( 0 ) exp ( - wt ) + M 0 w ( 1 - exp ( - wt ) ) + \u03bc exp ( - w ( t - \u03c4 ) ) - exp ( - w ( t - ( n + 1 ) \u03c4 ) ) 1 - exp ( w \u03c4 ) < V ( 0 ) exp ( - wt ) + M 0 w ( 1 - exp ( - wt ) ) + \u03bc exp ( - w ( t - \u03c4 ) ) 1 - exp ( w \u03c4 ) + \u03bc exp ( w \u03c4 ) exp ( w \u03c4 ) - 1 \u2192 M 0 w + \u03bc exp ( w \u03c4 ) exp ( w \u03c4 ) - 1 as t \u2192 \u221e . So V ( t ) is uniformly ultimately bounded. Hence, by the definition of V ( t ), there exists a constant M > 0 such that S ( t ) \u2a7d M , I ( t ) \u2a7d M for t large enough. The proof is complete. \u25a1 If S ( t ) = 0, we have the following subsystem of (2.3) : (3.2) I \u2032 ( t ) = - wI ( t ) , t \u2260 n \u03c4 , I ( n \u03c4 + ) = ( 1 - \u03bc 2 ) I ( n \u03c4 ) + \u03bc , t = n \u03c4 , n = 1 , 2 , \u2026 Obviously I ( t ) \u223c = \u03bc exp ( - w ( t - n \u03c4 ) ) 1 - ( 1 - \u03bc 2 ) exp ( - w \u03c4 ) , t \u2208 ( n \u03c4 , ( n + 1 ) \u03c4 ] , n \u2208 Z + , I ( 0 + ) \u223c = \u03bc 1 - ( 1 - \u03bc 2 ) exp ( - w \u03c4 ) is a positive periodic solution of (3.2) . Since the solution of (3.2) is I ( t ) = ( 1 - \u03bc 2 ) I ( 0 + ) \u223c - \u03bc 1 - ( 1 - \u03bc 2 ) exp ( - wt ) exp ( - wt ) + I ( t ) \u223c , t \u2208 ( n \u03c4 , ( n + 1 ) \u03c4 ] , n \u2208 Z + , so we derive Lemma\u00a04 System ( 3.2 ) has a positive periodic solution I ( t ) \u223c and for every solution I(t) of ( 3.2 ) we have I ( t ) \u2192 I ( t ) \u223c as t \u2192 \u221e . From the above discussion we know that (2.3) has a pest-extinction periodic solution (3.3) ( 0 , I ( t ) \u223c ) = 0 , \u03bc exp ( - w ( t - n \u03c4 ) ) 1 - ( 1 - \u03bc 2 ) exp ( - w \u03c4 ) for n\u03c4 < t \u2a7d ( n + 1) \u03c4 , and I ( n \u03c4 + ) \u223c = I ( 0 + ) \u223c = \u03bc 1 - ( 1 - \u03bc 2 ) exp ( - w \u03c4 ) , n \u2208 Z + . Theorem\u00a01 Let (S(t), I(t)) be any solution of ( 2.3 ) , if (3.4) ln 1 1 - \u03bc 1 > r \u03c4 - r \u03bc \u03b8 ( 1 - exp ( - w \u03c4 ) ) Kw ( 1 - ( 1 - \u03bc 2 ) exp ( - w \u03c4 ) ) - \u03b2 \u03bc 2 ( 1 - exp ( - 2 w \u03c4 ) ) 2 w ( 1 - ( 1 - \u03bc 2 ) exp ( - w \u03c4 ) ) 2 holds, then pest-extinction solution ( 0 , I ( t ) \u223c ) of ( 2.3 ) is globally asymptotically stable. Proof First, we prove the local stability. Defining s ( t ) = S ( t ), i ( t ) = I ( t ) - I ( t ) \u223c , we have the following linearly similar system for (2.3) which concerns one periodic solution ( 0 , I ( t ) \u223c ) : d s ( t ) d t d i ( t ) d t = r - r \u03b8 K I ( t ) \u223c - \u03b2 I ( t ) \u223c 2 0 - \u03b2 I ( t ) \u223c 2 - w s ( t ) i ( t ) . It is easy to obtain the fundamental solution matrix \u03a6 ( t ) = exp \u222b 0 t ( r - r \u03b8 K I ( s ) \u223c - \u03b2 I ( t ) \u223c 2 ) d s 0 \u2217 exp ( - wt ) . There is no need to calculate the exact form of \u2217 as it is not required in the analysis that follows. The linearization of the third and fourth equations of (2.3) is s ( n \u03c4 + ) i ( n \u03c4 + ) = 1 - \u03bc 1 0 0 1 - \u03bc 2 s ( n \u03c4 ) i ( n \u03c4 ) . The stability of the periodic solution ( 0 , I ( t ) \u223c ) is determined by the eigenvalues of M = 1 - \u03bc 1 0 0 1 - \u03bc 2 \u03d5 ( \u03c4 ) , where \u03bb 1 = ( 1 - \u03bc 2 ) exp ( - w \u03c4 ) < 1 , \u03bb 2 = ( 1 - \u03bc 1 ) exp \u222b 0 \u03c4 r - r \u03b8 K I ( s ) \u223c - \u03b2 I ( t ) \u223c 2 d s according to the Floquet theory [14] , if \u2223 \u03bb 2 \u2223 < 1, i.e. ln 1 1 - \u03bc 1 > r \u03c4 - r \u03bc \u03b8 ( 1 - exp ( - w \u03c4 ) ) Kw ( 1 - ( 1 - \u03bc 2 ) exp ( - w \u03c4 ) ) - \u03b2 \u03bc 2 ( 1 - exp ( - 2 w \u03c4 ) ) 2 w ( 1 - ( 1 - \u03bc 2 ) exp ( - w \u03c4 ) ) 2 holds, then ( 0 , I ( t ) \u223c ) is locally stable. In the following, we will prove the global attraction. Choose a \u03b5 > 0 such that \u03c1 = ( 1 - \u03bc 1 ) exp \u222b 0 \u03c4 r - r \u03b8 K ( I ( t ) \u223c - \u03b5 ) - \u03b2 ( I ( t ) \u223c - \u03b5 ) 2 d t < 1 . From the second equation of (2.3) we notice that d I ( t ) d t \u2a7e - wI ( t ) , so we consider the following impulsive differential equation: (3.5) d y ( t ) d t = - wy ( t ) , t \u2260 n \u03c4 , y ( t + ) = ( 1 - \u03bc 2 ) y ( t ) + \u03bc , t = n \u03c4 , y ( 0 + ) = I ( 0 + ) . From Lemma 2 and comparison theorem of impulsive equation (see Theorem 3.1.1 in [13] ), we have I ( t ) \u2a7e y ( t ) and y ( t ) \u2192 I ( t ) \u223c as t \u2192 \u221e. Then (3.6) I ( t ) \u2a7e y ( t ) \u2a7e I ( t ) \u223c - \u03b5 for all t large enough. For convenience we may assume (3.6) holds for all t \u2a7e 0, From (2.3) and (3.6) we get (3.7) d S ( t ) d t \u2a7d rS ( t ) 1 - r \u03b8 K ( I ( t ) \u223c - \u03b5 ) - \u03b2 ( I ( t ) \u223c - \u03b5 ) 2 , t \u2260 n \u03c4 , S ( n \u03c4 + ) = ( 1 - \u03bc 1 ) S ( n \u03c4 ) , t = n \u03c4 , n = 1 , 2 , \u2026 So S ( ( n + 1 ) \u03c4 ) \u2a7d S ( n \u03c4 + ) ( 1 - \u03bc 2 ) exp \u222b n \u03c4 ( n + 1 ) \u03c4 r - r \u03b8 K ( I ( s ) - \u03b5 ) - \u03b2 ( I ( t ) \u223c - \u03b5 ) 2 d s . Hence S ( n\u03c4 ) \u2a7d S (0 + ) \u03c1 n and S ( n\u03c4 ) \u2192 0 as n \u2192 \u221e, therefore S ( t ) \u2192 0 as t \u2192 \u221e. Next we prove that I ( t ) \u2192 I ( t ) \u223c as t \u2192 \u221e, For 0 < \u03b5 \u2a7d w , there must exist a t 0 > 0 such that 0 < S ( t ) < \u03b5 for all t \u2a7e t 0 . Without loss of generality, we may assume that 0 < S ( t ) < \u03b5 for all t \u2a7e 0, then for system (2.3) we have (3.8) - wI ( t ) \u2a7d d I ( t ) d t \u2a7d ( - w + \u03b5 ) I ( t ) then we have z 1 ( t ) \u2a7d I ( t ) \u2a7d z 2 ( t ) and z 1 ( t ) \u2192 I ( t ) \u223c , z 2 ( t ) \u2192 I ( t ) \u223c as t \u2192 \u221e. While z 1 ( t ) and z 2 ( t ) are the solutions of (3.9) d z 1 ( t ) d t = - wz 1 ( t ) , t \u2260 n \u03c4 , z 1 ( t + ) = ( 1 - \u03bc 2 ) z 1 ( t ) + \u03bc , t = n \u03c4 , z 1 ( 0 + ) = I ( 0 + ) and (3.10) d z 2 ( t ) d t = ( - w + \u03b5 ) z 2 ( t ) , t \u2260 n \u03c4 , z 2 ( t + ) = ( 1 - \u03bc 2 ) z 2 ( t ) + \u03bc , t = n \u03c4 , z 2 ( 0 + ) = I ( 0 + ) , respectively, z 2 ( t ) \u223c = \u03bc exp ( ( - w + \u03b5 ) ( t - n \u03c4 ) ) 1 - ( 1 - \u03bc 2 ) exp ( ( - w + \u03b5 ) \u03c4 ) for n\u03c4 < t \u2a7d ( n + 1) \u03c4 . Therefore, for any \u03b5 1 > 0, there exists a t 1 , t > t 1 such that I ( t ) \u223c - \u03b5 1 < I ( t ) < z 2 ( t ) \u223c + \u03b5 1 . Let \u03b5 \u2192 0, so we have I ( t ) \u223c - \u03b5 1 < I ( t ) < I ( t ) \u223c + \u03b5 1 for t large enough, which implies I ( t ) \u2192 I ( t ) \u223c as t \u2192 \u221e. This completes the proof. \u25a1 The next part is the investigation of the permanence of the system (2.3) . Before starting our theorem, we give the following definition. Definition\u00a03.1 System (2.3) is said to be permanent if there are constants m , M > 0 (independent of initial value) and a finite time T 0 such that for all solutions ( S ( t ), I ( t )) with all initial values S (0 + ) > 0, I (0 + ) > 0, m \u2a7d S ( t ) \u2a7d M , m \u2a7d I ( t ) \u2a7d M holds for all t \u2a7e T 0 . Here T 0 may depend on the initial values ( S (0 + ), ( I (0 + )). Theorem\u00a02 Let (S(t), I(t)) be any solution of ( 2.3 ) . If (3.11) ln 1 1 - \u03bc 1 < r \u03c4 - r \u03bc \u03b8 ( 1 - exp ( - w \u03c4 ) ) Kw ( 1 - ( 1 - \u03bc 2 ) exp ( - w \u03c4 ) ) - \u03b2 \u03bc 2 ( 1 - exp ( - 2 w \u03c4 ) ) 2 w ( 1 - ( 1 - \u03bc 2 ) exp ( - w \u03c4 ) ) 2 holds, then the system ( 2.3 ) is permanent. Proof Suppose ( S ( t ), I ( t )) is a solution of (2.3) with S (0) > 0, I (0) > 0. By Lemma 3 , we have proved there exists a constant M > 0 such that S ( t ) \u2a7d M , I ( t ) \u2a7d M for t large enough. We may assume S ( t ) \u2a7d M , I ( t ) \u2a7d M and M > r \u03b2 for t \u2a7e 0. From (3.6) we know I ( t ) > I ( t ) \u223c - \u03b5 2 for all t large enough and \u03b5 2 > 0, so I ( t ) \u2a7e \u03bc exp ( - w \u03c4 ) 1 - exp ( - w \u03c4 ) - \u03b5 2 = m 2 for t large enough. Thus, we only need to find m 1 > 0 such that S ( t ) \u2a7e m 1 for t large enough, we will do it in the following two steps. (1) By condition (3.11) , we can select m 3 > 0, \u03b5 1 > 0 small enough such that m 3 < w \u03b2 , \u03b4 = \u03b2 m 3 M < w , \u03c3 = r \u03c4 - r K m 3 \u03c4 - r \u03b8 K + \u03b2 \u03b5 1 2 \u03c4 - \u03bc w - \u03b4 r \u03b8 K + 2 \u03f5 1 1 - e ( - w + \u03b4 ) \u03c4 1 - ( 1 - \u03bc 2 ) e ( - w + \u03b4 ) \u03c4 + \u03b2 \u03bc 2 ( 1 - e 2 ( - w + \u03b4 ) \u03c4 ) 2 ( - w + \u03b4 ) ( 1 - ( 1 - \u03bc 2 ) e ( - w + \u03b4 ) \u03c4 ) > 0 , we will prove S ( t ) < m 3 cannot hold for t \u2a7e 0. Otherwise, (3.12) d I ( t ) d t \u2a7d ( - w + \u03b4 ) I ( t ) , t \u2260 n \u03c4 , I ( t + ) = ( 1 - \u03bc 2 ) I ( t ) + \u03bc , t = n \u03c4 . By Lemmas 3 and 4 , we have I ( t ) \u2a7d z ( t ) and z ( t ) \u2192 z ( t ) \u00af , t \u2192 \u221e , where z ( t ) is the solution of (3.13) d z ( t ) d t = ( - w + \u03b4 ) z ( t ) , t \u2260 n \u03c4 , z ( t + ) = z ( t ) + \u03bc , t = n \u03c4 , z ( 0 + ) = I ( 0 + ) and z 2 ( t ) \u223c = \u03bc exp ( ( - w + \u03b4 ) ( t - n \u03c4 ) ) 1 - ( 1 - \u03bc 2 ) exp ( ( - w + \u03b4 ) \u03c4 ) , t \u2208 ( n\u03c4 , ( n + 1) \u03c4 ]. Therefore, there exists a T 1 > 0 such that I ( t ) \u2a7d z ( t ) \u2a7d z ( t ) \u00af + \u03b5 1 and (3.14) d S ( t ) d t \u2a7e S ( t ) r - r K m 3 - r \u03b8 K ( z ( t ) \u00af + \u03b5 1 ) - \u03b2 ( z ( t ) \u00af + \u03b5 1 ) 2 , t \u2260 n \u03c4 , S ( t + ) = ( 1 - \u03bc 1 ) S ( t ) , t = n \u03c4 , n = 1 , 2 , \u2026 for t \u2a7e T 1 . Let N 1 \u2208 N and N 1 \u03c4 > T 1 . Integrating (3.14) on ( n\u03c4 , ( n + 1) \u03c4 ), n \u2a7e N 1 , we have S ( ( n + 1 ) \u03c4 ) \u2a7e ( 1 - \u03bc 1 ) S ( n \u03c4 + ) exp \u222b n \u03c4 ( n + 1 ) \u03c4 r - r K m 3 - r \u03b8 K ( z ( t ) \u00af + \u03b5 1 ) - \u03b2 ( z ( t ) \u00af + \u03b5 1 ) 2 d t = ( 1 - \u03bc 1 ) S ( n \u03c4 ) e \u03c3 then S (( N 1 + k ) \u03c4 ) \u2a7e (1 \u2212 \u03bc 1 ) k S ( N 1 \u03c4 + )e k\u03c3 \u2192 \u221e, as k \u2192 \u221e, which is a contradiction to the boundedness of S ( t ). Hence there exists a t 1 > 0 such that S ( t ) \u2a7e m 3 . (2) If S ( t ) \u2a7e m 3 for t \u2a7e t 1 , then our aim is obtained. Hence, we need only to consider those solutions which leave region R = { ( S ( t ) , I ( t ) ) \u2208 R + 2 : S ( t ) < m 3 } and reenter it again. Let t \u2217 = inf t \u2a7e t 1 { S ( t ) < m 3 } , then there are two possible cases for t \u2217 . \u25a1 Case\u00a01 t \u2217 = n\u03c4 , n 1 \u2208 Z + , then S ( t ) \u2a7e m 3 for t \u2208 [ t 1 , t \u2217 ) and S ( t \u2217 ) = m 3 . And (1 \u2212 \u03bc 1 ) m 3 \u2a7d S ( t + ) \u2a7d (1 \u2212 \u03bc 1 ) S ( t ) \u2a7d m 3 . Select n 2 , n 3 \u2208 N , such that n 2 \u03c4 > T 2 = ln \u03b5 1 M + \u03bc - w + \u03b4 , ( 1 - \u03bc 1 ) n 2 e n 3 \u03c3 e n 2 \u03c3 1 \u03c4 > ( 1 - \u03bc 1 ) n 2 e n 3 \u03c3 e ( n 2 + 1 ) \u03c3 1 \u03c4 > 1 , where \u03c3 1 = r - rm 3 K - \u03b8 K r - r \u03b8 K M - \u03b2 M 2 < 0 . Let T = n 1 \u03c4 + n 2 \u03c4 . We claim that there must be a t 2 \u2208 [ t \u2217 , t \u2217 + T ] such that S ( t 2 ) > m 3 . Otherwise, consider (3.13) with z ( t \u2217+ ) = I ( t \u2217+ ). We have z ( t ) = z ( t \u2217 + ) - \u03bc 1 - ( 1 - \u03bc 2 ) e ( - w + \u03b4 ) \u03c4 e ( - w + \u03b4 ) ( t - t \u2217 ) + z ( t ) \u00af , t \u2208 ( n\u03c4 , ( n + 1) \u03c4 ], n 1 \u2a7d n \u2a7d n 1 + n 2 + n 3 , then | z ( t ) - z ( t ) \u00af | < ( \u03bc + M ) e ( - w + \u03b4 ) ( t - ( n 1 + 1 ) \u03c4 ) < \u03b5 1 and I ( t ) \u2a7d z ( t ) \u2a7d z ( t ) \u00af + \u03b5 1 , t \u2217 + n 2 \u03c4 \u2a7d t \u2a7d t \u2217 + T , which implies (3.14) holds for t \u2217 + n 2 \u03c4 \u2a7d t \u2a7d t \u2217 + T . As in step1, we have S ( t \u2217 + T ) \u2a7e S ( ( t \u2217 + n 2 ) \u03c4 ) e n 3 \u03c3 . The first equation of (2.3) gives (3.15) d S ( t ) d t \u2a7e S ( t ) r - r K m 3 - r \u03b8 K M + \u03b2 M 2 = \u03c3 1 S ( t ) , t \u2260 n \u03c4 , S ( t + ) = ( 1 - \u03bc 1 ) S ( t ) , t = n \u03c4 . Integrating (3.15) on [ t \u2217 , t \u2217 + n 2 \u03c4 ], we have S ( t \u2217 + n 2 \u03c4 ) \u2a7e m 3 ( 1 - \u03bc 1 ) n 2 e \u03c3 1 n 2 \u03c4 . Thus we have S ( t \u2217 + T ) \u2a7e m 3 ( 1 - \u03bc 1 ) n 2 e \u03c3 1 n 2 \u03c4 e n 3 \u03c3 > m 3 which is a contradiction. Let t \u00af = inf t \u2a7e t \u2217 { S ( t ) \u2a7e m 3 } , thus S ( t \u00af ) \u2a7e m 3 for t \u2208 [ t \u2217 , t \u00af ] . We have S ( t ) \u2a7e ( 1 - \u03bc 1 ) n 2 + n 3 S ( t \u2217 ) e \u03c3 1 ( t - t \u2217 ) \u2a7e ( 1 - \u03bc 1 ) n 2 + n 3 m 3 e \u03c3 1 ( n 2 + n 3 ) = m 1 for t \u2a7e t \u00af . So we have S ( t ) \u2a7e m 1 . The same arguments can be continued since S ( t \u00af ) \u2a7e m 3 . Hence S ( t ) \u2a7e m 1 for all t \u2a7e t 1 . Case\u00a02 t \u2260 n\u03c4 , n \u2208 Z + , then S ( t ) \u2a7e m 3 for t \u2a7e t 1 \u2032 , and S ( t \u2217 ) = m 3 . Let t \u2217 = inf t \u2a7e t 1 \u2032 { S ( t ) < m 3 } , then S ( t ) \u2a7e m 3 for t \u2208 [ t 1 \u2032 , t \u2217 ) and S ( t \u2217 ) = m 3 . Suppose t \u2217 \u2208 [ n 1 \u2032 \u03c4 , ( n 1 \u2032 + 1 ) \u03c4 ) , n 1 \u2032 \u2208 N . We claim that there must be a t 2 \u2032 \u2208 [ ( n 1 \u2032 + 1 ) \u03c4 , ( n 1 \u2032 + 1 ) \u03c4 + T ] . Consider (3.13) with z ( ( n 1 \u2032 + 1 ) \u03c4 + ) = I ( ( n 1 \u2032 + 1 ) \u03c4 + ) . We have z ( t ) = z ( ( n 1 + 1 ) \u03c4 + ) - \u03bc 1 - ( 1 - \u03bc 2 ) e ( - w + \u03b4 ) \u03c4 e ( - w + \u03b4 ) ( t - ( n 1 \u2032 + 1 ) \u03c4 ) + z ( t ) \u00af , t \u2208 ( n\u03c4 , ( n + 1) \u03c4 ], n 1 \u2032 + 1 \u2a7d n \u2a7d n 1 \u2032 + 1 + n 2 + n 3 , then | z ( t ) - z ( t ) \u00af | < ( \u03bc + M ) e ( - w + \u03b4 ) ( t - ( n 1 \u2032 + 1 ) \u03c4 ) < \u03b5 1 and I ( t ) \u2a7d z ( t ) \u2a7d z ( t ) \u00af + \u03b5 1 , ( n 1 \u2032 + 1 + n 2 ) \u03c4 \u2a7d t \u2a7d ( n 1 \u2032 + 1 + T ) \u03c4 , which implies (3.14) holds for ( n 1 \u2032 + 1 + n 2 ) \u03c4 \u2a7d t \u2a7d ( n 1 \u2032 + 1 ) \u03c4 + T . As in step1, we have S ( ( n 1 \u2032 + 1 + n 2 + n 3 ) \u03c4 ) \u2a7e ( 1 - \u03bc 1 ) n 3 S ( ( n 1 \u2032 + 1 + n 2 ) \u03c4 ) e n 3 \u03c3 . The first equation of (2.3) gives d S ( t ) d t \u2a7e S ( t ) r - r K m 3 - r \u03b8 K + \u03b2 M = \u03c3 1 S ( t ) . Integrating it on [ t \u2217 , ( n 1 \u2032 + 1 + n 2 ) \u03c4 ] , we have S ( ( n 1 \u2032 + 1 + n 2 ) \u03c4 ) \u2a7e ( 1 - \u03bc 1 ) n 2 + 1 m 3 e \u03c3 1 ( n 2 + 1 ) \u03c4 . Then S ( ( n 1 \u2032 + 1 + n 2 + n 3 ) \u03c4 ) \u2a7e m 3 e \u03c3 1 ( n 2 + 1 ) \u03c4 e n 3 \u03c3 > m 3 which is a contradiction. Let t \u00af \u2032 = inf t \u2a7e t \u2217 { S ( t ) \u2a7e m 3 } , thus S ( t \u00af \u2032 ) \u2a7e m 3 for t \u2208 [ t \u2217 , t \u00af ] . We have S ( t ) \u2a7e S ( t \u2217 ) e \u03c3 1 ( t - t \u2217 ) \u2a7e m 3 e \u03c3 1 ( 1 + n 2 + n 3 ) = m 1 for t \u2a7e t \u00af \u2032 . The same arguments can be continued since S ( t \u00af \u2032 ) \u2a7e m 3 . Hence S ( t ) \u2a7e m 1 for all t \u2a7e t 1 , The proof is complete. Remark\u00a03.1 Let f ( \u03c4 ) = r \u03c4 - r \u03bc \u03b8 ( 1 - exp ( - w \u03c4 ) ) Kw ( 1 - ( 1 - \u03bc 2 ) exp ( - w \u03c4 ) ) - \u03b2 \u03bc 2 ( 1 - exp ( - 2 w \u03c4 ) ) 2 w ( 1 - ( 1 - \u03bc 2 ) exp ( - w \u03c4 ) ) 2 - ln 1 1 - \u03bc 1 , we easily know f ( 0 ) = - ln 1 1 - \u03bc 1 < 0 , f ( \u03c4 ) \u2192 \u221e as \u03c4 \u2192 \u221e, and f \u2033 ( \u03c4 ) = r \u03bc \u03bc 2 \u03b8 w 2 ( 1 - ( 1 - \u03bc 2 ) e - w \u03c4 ) ( 1 - ( 1 - \u03bc 2 ) e - w \u03c4 ) 3 + 2 e - 2 w + e - 3 w { 3 ( 1 - \u03bc 2 ) - 2 ( 1 - \u03bc 2 ) 2 e w \u03c4 + ( 1 - \u03bc 2 ) e 2 w } ( 1 - ( 1 - \u03bc 2 ) e - w \u03c4 ) 4 \u03b2 w \u03bc 2 > 0 . So f ( \u03c4 ) = 0 has a unique positive root, denoted by \u03c4 max . From Theorems 1 and 2 we know \u03c4 max is a threshold. If \u03c4 < \u03c4 max , then the pest-extinction solution ( 0 , I ( t ) \u223c ) of system (2.3) is globally asymptotically stable. If \u03c4 > \u03c4 max , then the system (2.3) is permanent. Remark\u00a03.2 If \u03bc = 0, i.e. there are no periodic releasing infective pests. Thus, we can easily obtain that \u03c4 1 = ln 1 1 - \u03bc 1 is the threshold. Obviously, \u03c4 max > \u03c4 1 , i.e. impulsively releasing infective pests may lengthen the period of spraying pesticides and therefore reduce the cost of pests control. 4 Discussion In this paper, according to the fact, an SI model with impulsive transmitting infective pests and spraying pesticides at fixed moment is proposed and investigated, we analyzed the pest-extinction periodic solution of such a system which is global asymptotic stability, and obtained the condition for the permanence of system (2.3) . There are some interesting problems: how to optimize the amount of spraying pesticides? What is the determining time of impulsive releasing infective pests depending on the state of insect pest? How this impulsive releasing infective pest affect the system? In the real world, for the insect pest is with seasonal damages, should impulsive releasing infective be considered on finite interval? We will continue to study these problems in the future. References [1] L.A. Falcon Use of Bacteria for Microbial Control of Insects 1971 Academic Press New York, NY [2] H.D. Burges N.W. Hussey Microbial Control of Insects and Mites 1971 Academic Press New York, NY pp. 67\u201395 [3] L.A. Falcon Problems associated with the use of arthropod viruses in pest control Ann. Rev. Entomol. 21 1976 305 324 [4] F. Fenner F.N. Ratcliffe Myxomatosis 1965 Cambridge University Press pp. 379 [5] R.M. Anderson R.M. May Regulation and stability of host-parasity population interactions, I. Regulatory processes J. Anim. Ecol. 47 1978 219 247 [6] B.S. Goh The potential utility of control theory to pest management Proc. Ecol. Soc. 6 1971 84 89 [7] P.E. Davis K. Myers J.B. Hoy Biological control among vertebrates C.B. Huffaker P.S. Messenger Theory and Practice of Biological Control 1976 Plenum Press New York, NY 501 519 [8] N.T.J. Bailey The Mathematical Theory of Infectious Diseases and its Applications 1975 Griffin London pp. 413 [9] H.D. Burges N.W. Hussey Microbial Control of Insects and Mites 1971 Academic Press New York, NY pp. 861 [10] Y. Tanada Epizootiology of insect diseases P. Debach Biological Control of Insect Pests and Weeds 1964 Chapman and Hall London 548 578 [11] N. Gilbert A.P. Gutierrez B.D. Frazer R.E. Jones Ecological Relationships 1976 W.H. Freeman and Co. San Francisco, CA [12] Bean Sangoh Management and Analysis of Biological Populations 1980 Elsevier Scientific Press Company [13] V. Lakshmikantham D.D. Bainov P. Simeonov Theory of Impulsive Differential Equations 1989 World Scientific Singapore [14] D. Bainov P. Simeonov Impulsive differential equations: periodic solutions and applications Pitman Monographs Surveys Pure Appl. Math. 66 1993 [15] H.J. Barclay Models for pest control using predator release, habitat management and pesticide release in combination J. Appl. Ecol. 19 1982 337 348 [16] J.C. Paneyya A mathematical model of periodically pulse chemotherapy: tumor recurrence and metastasis in a competition environment Bull. Math. Biol. 58 1996 425 447 [17] A. d\u2019Onofrio Stability properties of pulse vaccination strategy in SEIR epidemic model Math. Biol. 179 2002 57 72 [18] J.C. Van Lanteren Integrated pest management in protected crops D. Dent Integrated Pest Management 1995 Chapman and Hall London [19] M.G. Roberts R.R. Kao The dynamics of an infectious disease in a population with birth pulse Math. Biol. 149 2002 23 36 [20] Y.N. Xiao L.S. Chen A ratio-dependent predator\u2013prey model with disease in the prey Appl. Math. Comput. 131 2002 397 414 [21] Y.N. Xiao L.S. Chen An SIS epidemic model with stage structure and a delay Acta Math. Appl. English Ser. 16 2002 607 618 [22] Y.N. Xiao L.S. Chen F.V.D. Bosh Dynamical behavior for stage-structured SIR infectious disease model Nonlinear Anal.: RWA 3 2002 175 190 [23] Y.N. Xiao L.S. Chen On an SIS epidemic model with stage-structure J. Syst. Sci. Complexity 16 2003 275 288 [24] Z.H. Lu S.J. Gang L.S. Chen Analysis of an SI epidemic with nonlinear transmission and stage structure Acta Math. Sci. 4 2003 440 446 [25] H. Hethcote The mathematics of infectious disease SIAM Rev. 42 2002 599 653 [26] R. Anderson R. May Population Biological of Infectious Diseases 1982 Springer Berlin, Heidelberg, New York [27] R. Anderson R. May Infectious Diseases of Human: Dynamics and Control 1991 Oxford University Press [28] M.C.M. De Jong O. Diekmann J.A.P. Heesterbeek How dose transmission depend on population size? D. Mollison Human Infectious Diseases, Epidemic Models 1995 Cambridge University Press Cambridge, UK 84 94 [29] Wei-min S.A. Levin Y. Lwasa Influence of nonlinear incidence rates upon the behavior of SIRS Epidemiological models J. Math. Biol. 25 1987 359 380 [30] Wei-min H.W. Hethcote S.A. Levin Dynamical behavior of epidemiological models with nonlinear incidence rates J. Math. Biol. 23 1986 187 240 [31] K. Wickwire Mathematical models for the control of pests and infectious diseases: a survey Theor. Popul. Biol. 8 1977 182 238",
        "keywords": [
            "chemical control",
            "impulsive",
            "infective",
            "pest- extinction",
            "pest management",
            "satisfiability"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, People\u2019s Republic of China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2006
    },
    "XMirh292": {
        "id": "XMirh292",
        "title": "The periodic solution of a class of epidemic models",
        "abstract": "This paper has completely studied the dynamical properties of a class of epidemiological models, obtained the necessary and sufficient condition for a unique periodic solution which is asymptotically orbitally stable, and the necessary and sufficient conditions for the global asymptotic stability of the positive equilibrium.",
        "keywords": [
            "global asymptotic stability",
            "nonlinear incidence rate",
            "periodic solution",
            "epidemic model",
            "incidence rate"
        ],
        "authors": [
            {
                "name": "Xin-An Zhang",
                "org": "Institute of Mathematics, Academia Sinica Beijing, 100080, P.R. China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academia Sinica Beijing, 100080, P.R. China"
            }
        ],
        "venue": "Computers and Mathematics with Applications",
        "year": 1999
    },
    "5HXZxpNi": {
        "id": "5HXZxpNi",
        "title": "Geometric properties of solution of a cylindrical dynamic system with impulsive state feedback control",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "hongjian guo",
                "org": ""
            },
            {
                "name": "lansun chen",
                "org": ""
            },
            {
                "name": "xinyu song",
                "org": ""
            }
        ],
        "venue": "Nonlinear Analysis: Hybrid Systems",
        "year": 2015
    },
    "iAb2NLow": {
        "id": "iAb2NLow",
        "title": "Pulse vaccination strategy in a delayed sir epidemic model with vertical transmission",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "lansun chen",
                "org": ""
            },
            {
                "name": "dehui xie",
                "org": ""
            },
            {
                "name": "shujing gao",
                "org": ""
            }
        ],
        "venue": "Discrete and Continuous Dynamical Systems-series B",
        "year": 2006
    },
    "0EwPchR3": {
        "id": "0EwPchR3",
        "title": "Dynamical analysis of a biological resource management model with impulsive releasing and harvesting",
        "abstract": "In this study, we consider a biological resource management predator-prey model with impulsive releasing and harvesting at different moments. First, we prove that all solutions of the investigated system are uniformly ultimately bounded. Second, the conditions of the globally asymptotic stability predator-extinction boundary periodic solution are obtained. Third, the permanence condition of the investigated system is also obtained. Finally, the numerical simulation verifies our results. These results provide reliable tactic basis for the biological resource management in practice. \u00a9 2012 Jiao et al.",
        "keywords": [
            "extinction",
            "impulsive harvesting",
            "impulsive releasing",
            "permanence",
            "predator-prey model"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": "Guizhou University(Guizhou University),Guiyang,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and System Sciences Chinese Academy of Sciences(Chinese Academy of Sciences,Academy of Mathematics and Systems Science),Beijing,China"
            },
            {
                "name": "Shaohong Cai",
                "org": "Guizhou University(Guizhou University),Guiyang,China"
            }
        ],
        "venue": "Advances in Difference Equations",
        "year": 2012
    },
    "ZOku64XE": {
        "id": "ZOku64XE",
        "title": "Global asymptotic stability in N-species nonautonomous Lotka-Volterra competitive systems with delays",
        "abstract": "A delayed n-species nonautonomous Lotka-Volterra type competitive system without dominating instantaneous negative feedback is investigated. By means of a suitable Lyapunov functional, sufficient conditions are derived for the global asymptotic stability of the positive solutions of the system. As a corollary, it is shown that the global asymptotic stability of the positive solution is maintained provided that the delayed negative feedbacks dominate other interspecific interaction effects with delays and the delays are sufficiently small.",
        "keywords": [
            "Finite and Infinite delay",
            "Global asymptotic stability",
            "Lyapunov functional",
            "Nonautonomous Lotka-Volterra competitive system"
        ],
        "authors": [
            {
                "name": "Rui Xu",
                "org": "Shijiazhuang Mechanical Engineering College(Mechanical Engineering College,Shijiazhuang Mechanical Engineering College,College of Mechanical Engineering,Shijiazhuang Mech. Eng. College),Shijiazhuang,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "Mark A J Chaplain",
                "org": "University of Dundee(University of Dundee),Dundee,United Kingdom"
            }
        ],
        "venue": "Acta Mathematica Scientia",
        "year": 2003
    },
    "RikOdCpk": {
        "id": "RikOdCpk",
        "title": "The dynamics of a mutual interference age structured predator-prey model with time delay and impulsive perturbations on predators",
        "abstract": "In this paper, we introduce a mutual interference age structured predator-prey (natural enemy-pest) model with constant maturation time delay for the prey, and then propose a pest management strategy by constant periodic releasing for the predator. We show that there exists a global attractive pest-eradication periodic solution when the periodic releasing amount @m\\\"1 and @m\\\"2 are lager than some critical value. Further, to obtain a more effective pest control strategy, we give the conditions (involving the estimate of @m\\\"1 and @m\\\"2) in which the model is uniformly permanent and the pest population is under the economic threshold level. We believe that the results will provide reliable tactic basis for the practical pest management.",
        "keywords": [
            "age structured",
            "impulsive perturbations",
            "permanence",
            "mutual interference",
            "global attractivity",
            "maturation time delay",
            "age structure",
            "critical value",
            "pest management",
            "pest control"
        ],
        "authors": [
            {
                "name": "Guanghu Zhu",
                "org": ""
            },
            {
                "name": "Xinzhu Meng",
                "org": "College of Information Science and Engineering, Shangdong University of Science and Technology, Qingdao 266510, People\u2019s Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and Science, Beijing 100080, People\u2019s Republic of China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2010
    },
    "NAH4AOv5": {
        "id": "NAH4AOv5",
        "title": "Periodic solution of a chemostat model with variable yield and impulsive state feedback control",
        "abstract": "In this paper, a chemostat model with variable yield and impulsive state feedback control is considered. We obtain sufficient conditions of the globally asymptotical stability of the system without impulsive state feedback control. We also obtain that the system with impulsive state feedback control has periodic solution of order one. Sufficient conditions for existence and stability of periodic solution of order one are given. In some cases, it is possible that the system exists periodic solution of order two. Our results show that the control measure is effective and reliable. \u00a9 2011 Elsevier Inc.",
        "keywords": [
            "Chemostat",
            "Globally asymptotical stability",
            "Impulsive effect",
            "Periodic solution",
            "State feedback control"
        ],
        "authors": [
            {
                "name": "Zuxiong Li",
                "org": "Hubei University(Hubei University,Hubei University of Technology),Wuhan,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            },
            {
                "name": "Zhijun Liu",
                "org": "Hubei University(Hubei University,Hubei University of Technology),Wuhan,China"
            }
        ],
        "venue": "Applied Mathematical Modelling",
        "year": 2012
    },
    "DPB8U6Mx": {
        "id": "DPB8U6Mx",
        "title": "Persistence and stability for a two-species ratio-dependent predator-prey system with time delay in a two-patch environment",
        "abstract": "A two-species ratio-dependent predator-prey diffusion model with time delay is investigated. It is shown that the system is permanent under some appropriate conditions, and sufficient conditions are obtained for the local and global stability of the positive equilibrium of the system.",
        "keywords": [
            "global asymptotic stability",
            "time delay",
            "uniform persistence",
            "diffusion"
        ],
        "authors": [
            {
                "name": "Rui Xu",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Computers and Mathematics with Applications",
        "year": 2000
    },
    "by7AIxqb": {
        "id": "by7AIxqb",
        "title": "Bifurcation and chaos in a Monod type food chain chemostat with pulsed input and washout",
        "abstract": "In this paper, we introduce and study a model of a Monod type food chain chemostat with pulsed input and washout. We investigate the subsystem with substrate and prey and study the stability of the periodic solutions, which are the boundary periodic solutions of the system. The stability analysis of the boundary periodic solution yields an invasion threshold. By use of standard techniques of bifurcation theory, we prove that above this threshold there are periodic oscillations in substrate, prey and predator. Simple cycles may give way to chaos in a cascade of period-doubling bifurcations. Furthermore, by comparing bifurcation diagrams with different bifurcation parameters, we can see that the impulsive system shows two kinds of bifurcations, whose are period-doubling and period-halving.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Fengyan Wang",
                "org": ""
            },
            {
                "name": "Chunping Hao",
                "org": "Department of Information and Computer Science, The Second Northwest University for Minorities, Yinchuan Ningxia 750021, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2007
    },
    "NbrXnYkJ": {
        "id": "NbrXnYkJ",
        "title": "The linear and nonlinear diffusion of the competitive Lotka\u2013Volterra model",
        "abstract": "This paper has studied the effects of linear and nonlinear diffusion of the competitive Lotka\u2013Volterra model, and has investigated how the linear and nonlinear diffusions lead from the extinction of one species to the persistence or global asymptotic stability of all species. This research has important implications in the design of nature reserves.",
        "keywords": [
            "extinction",
            "persistence",
            "58f09",
            "92d25",
            "nonlinear diffusion",
            "coexistence",
            "34c05",
            "nature reserve"
        ],
        "authors": [
            {
                "name": "Xin-an Zhang",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academia Sinica, Beijing, 100080, PR China"
            }
        ],
        "venue": "Nonlinear Analysis",
        "year": 2007
    },
    "UXmdn9zD": {
        "id": "UXmdn9zD",
        "title": "PULSE FISHING POLICY FOR A STAGE-STRUCTURED MODEL WITH STATE-DEPENDENT HARVESTING",
        "abstract": "",
        "keywords": [
            "pulse fishing policy",
            "stage-structured",
            "state-dependent harvesting"
        ],
        "authors": [
            {
                "name": "JIANJUN JIAO",
                "org": ""
            },
            {
                "name": "LANSUN CHEN",
                "org": ""
            },
            {
                "name": "WEN LONG",
                "org": ""
            }
        ],
        "venue": "Journal of Biological Systems",
        "year": 2007
    },
    "ipNDjhY9": {
        "id": "ipNDjhY9",
        "title": "Permanence and extinction of periodic predator-prey systems in a patchy environment with delay",
        "abstract": "This paper studies two species predator-prey Lotka-Volterra type dispersal systems with periodic coefficients and infinite delays, in which the prey species can disperse among n-patches, but the predator species is confined to one patch and cannot disperse. Sufficient and necessary conditions of integrable form for the permanence, extinction and the existence of positive periodic solutions are established, respectively. Some well-known results on the nondelayed periodic predator-prey Lotka-Volterra type dispersal systems are improved and extended to the delayed case.",
        "keywords": [
            "permanence",
            "extinction",
            "prey species",
            "92d25",
            "infinite delay",
            "patchy environment",
            "predator\u2013prey",
            "periodic coefficient",
            "periodic solution",
            "integrable form",
            "34k25",
            "periodic predator-prey system",
            "lotka-volterra type dispersal system",
            "positive periodic solution",
            "lotka\u2013volterra system",
            "delay",
            "delayed case",
            "type dispersal system",
            "predator species",
            "nondelayed periodic predator-prey lotka-volterra",
            "dispersion",
            "predator prey"
        ],
        "authors": [
            {
                "name": "Zhidong Teng",
                "org": "Department of Mathematics, Xinjiang University, Urumqi 830046, People's Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Chinese Science Academia, Beijing 100080, People's Republic of China"
            }
        ],
        "venue": "Nonlinear Analysis: Real World Applications",
        "year": 2003
    },
    "nZicHjvM": {
        "id": "nZicHjvM",
        "title": "The Effect of Seasonal harvesting on a Stage-Structured Discrete Model with Birth Pulses",
        "abstract": "",
        "keywords": [
            "Birth pulse",
            "Chaos",
            "Discrete model",
            "Period-doubling bifurcation",
            "Period-halving bifurcation",
            "Seasonal harvesting",
            "Stage structure"
        ],
        "authors": [
            {
                "name": "Shujing Gao",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "I. J. Bifurcation and Chaos",
        "year": 2006
    },
    "kXYvFuGD": {
        "id": "kXYvFuGD",
        "title": "The periodic n-species Gilpin\u2013Ayala competition system with impulsive effect",
        "abstract": "In this paper, a generalized periodic n -species Gilpin\u2013Ayala competition systems with impulsive effect is investigated. The sufficient conditions are derived for the permanence of the system. We discuss the stabilities of trivial solution and bounded periodic solution. By using the method of coincidence degree, a set of sufficient conditions are derived for the existence of at least one strictly positive componentwise periodic solution, the example shows that our criteria are easily verifiable.",
        "keywords": [],
        "authors": [
            {
                "name": "Shuwen Zhang",
                "org": ""
            },
            {
                "name": "Dejun Tan",
                "org": "Institute of Biomathematics, Anshan Normal University, Anshan, Liaoning 114005, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian, Liaoning 116024, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2005
    },
    "AZknzEF1": {
        "id": "AZknzEF1",
        "title": "Dynamical behavior for a stage-structured SIR infectious disease model",
        "abstract": "",
        "keywords": [
            "globally asymptotically stable",
            "sir infectious disease",
            "time delay",
            "stage structure",
            "stage-structured sir infectious disease",
            "dynamical behavior",
            "infectious disease"
        ],
        "authors": [
            {
                "name": "Yanni Xiao",
                "org": "Academy of Mathematics & System Sciences, Academia Sinica, Beijing 100080, People's Republic of China and Department of Statistics, IACR-Rothmasted, Harpenden, Westfordshire, UK"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics & System Sciences, Academia Sinica, Beijing, People's Republic of China"
            },
            {
                "name": "Frank ven den Bosch",
                "org": "Department of Statistics, IACR-Rothmasted, Harpenden, Westfordshire, UK"
            }
        ],
        "venue": "Nonlinear Analysis: Real World Applications",
        "year": 2002
    },
    "MH07m5XA": {
        "id": "MH07m5XA",
        "title": "On positive periodic solutions of a nonautonomous neutral delay n-species competitive system",
        "abstract": "The purpose of this paper is to investigate a general neutral delay n -species competitive nonautonomous system. Different from Gaines and Mawhin\u2019s continuation theorem [R.E. Gaines, J.L. Mawhin, Coincidence Degree and Nonlinear Differential Equations, Springer-Verlag, Berlin, 1977] and abstract continuation theory for k -set contraction [W. Petryshyn, Z. Yu, Existence theorem for periodic solutions of higher order nonlinear periodic boundary value problems, Nonlinear Anal. 6 (1982) 943\u2013969; R.E. Gaines, J.L. Mawhin, Lecture Notes in Mathematics, vol. 586, Springer-Verlag, Berlin, 1977], a new existence theorem is introduced. With the help of the theorem and some techniques, a set of sufficient conditions are derived for the existence of at least one strictly positive (componentwise) periodic solution. As an application, we also examine some special cases which have been studied extensively in the literature. Some known results are improved and generalized.",
        "keywords": [
            "existence theorem",
            "positive periodic solution",
            "34k15",
            "34a12",
            "competition system",
            "neutral delay",
            "34c25",
            "higher order"
        ],
        "authors": [
            {
                "name": "Zhijun Liu",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Academia Sinica, Beijing 100080, PR China"
            }
        ],
        "venue": "Nonlinear Analysis",
        "year": 2008
    },
    "UMaoHRCx": {
        "id": "UMaoHRCx",
        "title": "Extinction and permanence of two-nutrient and two-microorganism chemostat model with pulsed input",
        "abstract": "",
        "keywords": [
            "chemostat model",
            "periodic solution",
            "permanence",
            "stability",
            "competitive exclusion",
            "numerical simulation"
        ],
        "authors": [
            {
                "name": "Tieying Wang",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            },
            {
                "name": "Ping Zhang",
                "org": ""
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2010
    },
    "Fgbl1zEl": {
        "id": "Fgbl1zEl",
        "title": "Periodic solutions and homoclinic bifurcation of a predator-prey system with two types of harvesting",
        "abstract": "In this paper, a predator-prey model with both constant rate harvesting and state dependent impulsive harvesting is analyzed. By using differential equation geometry theory and the method of successor functions, the existence, uniqueness and stability of the order one periodic solution have been studied. Sufficient conditions which guarantee the nonexistence of order k (k\u22652) periodic solution are given. We also present that the system exhibits the phenomenon of homoclinic bifurcation under some parametric conditions. Finally, some numerical simulations and biological explanations are given. \u00a9 2013 Springer Science+Business Media Dordrecht.",
        "keywords": [
            "homoclinic bifurcation",
            "orbitally asymptotically stable",
            "order k periodic solution",
            "predator-prey system",
            "successor function"
        ],
        "authors": [
            {
                "name": "Mingzhan Huang",
                "org": "Xinyang Normal University(Xinyang Normal University),Xinyang,China"
            },
            {
                "name": "Shouzong Liu",
                "org": "Xinyang Normal University(Xinyang Normal University),Xinyang,China"
            },
            {
                "name": "Xinyu Song",
                "org": "Xinyang Normal University(Xinyang Normal University),Xinyang,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and System Sciences Chinese Academy of Sciences(Chinese Academy of Sciences,Academy of Mathematics and Systems Science),Beijing,China"
            }
        ],
        "venue": "Nonlinear Dynamics",
        "year": 2013
    },
    "FReVH78H": {
        "id": "FReVH78H",
        "title": "Dynamic complexities in a periodically pulsed ratio-dependent predator\u2013prey ecosystem modeled on a chemostat",
        "abstract": "This paper contains a three dimensional ratio-dependent predator\u2013prey system modeling for a chemostat with predator, prey and periodically pulsed substrate. Using the discrete dynamical system determined by the stroboscopic map, we obtain an exact periodic solution with positive concentrations of substrate and prey in the absence of the protozoan predator. A stability analysis for this solution yields an invasion threshold (the smallest value of the predator\u2019s predation constant consistent with invasion of the chemostat). Above this threshold, there are periodic oscillations in substrate, prey and predator. Increasing the predator\u2019s predation constant yields a series of period-doubling bifurcations, leading to chaotic dynamics, which implies that the dynamical behaviors of the periodically pulsed ratio-dependent predator\u2013prey ecosystem are very complex, including small-amplitude oscillations, large-amplitude cycles, and chaos. This suggests that limiting substrate pulse, in effect, provides a natural period or cyclicity that allows for a period-doubling route to chaos.",
        "keywords": [
            "three dimensional",
            "stability analysis",
            "ecosystem model",
            "oscillations"
        ],
        "authors": [
            {
                "name": "Jing Hui",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2006
    },
    "LZuKoQEP": {
        "id": "LZuKoQEP",
        "title": "Dynamical analysis of a delayed predator-prey system with birth pulse and impulsive harvesting at different moments",
        "abstract": "We consider a delayed Holling type II predator-prey system with birth pulse and impulsive harvesting on predator population at different moments. Firstly, we prove that all solutions of the investigated system are uniformly ultimately bounded. Secondly, the conditions of the globally attractive prey-extinction boundary periodic solution of the investigated system are obtained. Finally, the permanence of the investigated system is also obtained. Our results provide reliable tactic basis for the practical biological economics management. Copyright \u00a9 2010 Jianjun Jiao and Lansun Chen.",
        "keywords": [
            "Periodic Solution",
            " Global Attraction",
            " Comparison Theorem",
            " Predator Population",
            " Impulsive Differential Equation"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": "Guizhou College of Finance and Economics(Guizhou College of Finance and Economics),Guiyang,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and System Sciences Chinese Academy of Sciences(Chinese Academy of Sciences,Academy of Mathematics and Systems Science),Beijing,China"
            }
        ],
        "venue": "Advances in Difference Equations",
        "year": 2010
    },
    "cIJOXHUz": {
        "id": "cIJOXHUz",
        "title": "PERMANENCE AND COMPLEXITY OF THE ECO-EPIDEMIOLOGICAL MODEL WITH IMPULSIVE PERTURBATION",
        "abstract": "",
        "keywords": [
            "bifurcation diagram",
            "chaotic attractor",
            "complexity",
            "eco-epidemiological model",
            "permanence"
        ],
        "authors": [
            {
                "name": "SHULIN SUN",
                "org": ""
            },
            {
                "name": "LANSUN CHEN",
                "org": ""
            }
        ],
        "venue": "International Journal of Biomathematics",
        "year": 2008
    },
    "RWRjPEjx": {
        "id": "RWRjPEjx",
        "title": "Feasibility of time-limited control of a competition system with impulsive harvest",
        "abstract": "A kind of time-limited control model on a competition system with impulsive harvest, described by impulsive differential equation with the initial and boundary value problem, is presented. The existence of solution of the model, corresponding to the feasibility of the short-term control, is discussed. By the comparison principle, the conditions under which the model has a solution are found by a series of the upper solutions, and the conditions under which the model has no solution are also given by a series of the lower solutions. Finally, the practical meanings of those conditions are explained. As an example, if other parameters are given, the times of the impulsive control is estimated and the theoretical results are verified by numerical simulations.",
        "keywords": [
            "impulsive differential equation",
            "competition system",
            "upper and lower solution",
            "comparison principle",
            "boundary value problem",
            "impulsive control",
            "numerical simulation"
        ],
        "authors": [
            {
                "name": "Hongjian Guo",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, PR China"
            },
            {
                "name": "Xinyu Song",
                "org": "Department of Mathematics, Xinyang Normal University, Xinyang 464000, PR China"
            }
        ],
        "venue": "Nonlinear Analysis: Real World Applications",
        "year": 2010
    },
    "deZTbgN3": {
        "id": "deZTbgN3",
        "title": "Dynamic complexity of microbial pesticide model",
        "abstract": "In this paper, a mathematical model for the entomopathogenic nematode attacking the pest is investigated. This novel theoretical\n framework could result in an objective criterion on how to release the entomopathogenic nematode in order to control the pest\n population under the economic threshold (ET) which indicates the maximally admissible pest densities. Firstly, continuous\n release of the entomopathogenic nematode is taken. By using qualitative analysis method, the sufficient condition of the global\n stability of the positive equilibria and the existence and uniqueness of limit cycle of the system are obtained. Secondly,\n impulsive release of the entomopathogenic nematode is also considered. Using the Floquet\u2019s theorem and small-amplitude perturbation,\n we obtain that the pest-free periodic solution is locally stable if some conditions are satisfied. In a certain limiting case,\n it is shown that a nontrivial periodic solution emerges via a supercritical bifurcation. Finally, our findings are confirmed\n by means of numerical simulations.",
        "keywords": [
            "Microbial pesticide",
            "Entomogenous nematode",
            "Qualitative analysis",
            "Continuous release",
            "Impulsive release"
        ],
        "authors": [
            {
                "name": "Tieying Wang",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116024 People\u2019s Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116024 People\u2019s Republic of China"
            }
        ],
        "venue": "Nonlinear Dynamics",
        "year": 2009
    },
    "pf6piijv": {
        "id": "pf6piijv",
        "title": "Erratum to: The effect of pulsed harvesting policy on the inshore\u2013offshore fishery model with the impulsive diffusion",
        "abstract": "",
        "keywords": [
            "numerical simulation"
        ],
        "authors": [
            {
                "name": "zhong zhao",
                "org": "dalian university of technology"
            },
            {
                "name": "xiuquan zhang",
                "org": "Department of Mathematics,Huanghuai University,Zhumadian,P.R. China"
            },
            {
                "name": "lansun chen",
                "org": "dalian university of technology"
            }
        ],
        "venue": "Nonlinear Dynamics",
        "year": 2010
    },
    "n8lUdG0m": {
        "id": "n8lUdG0m",
        "title": "The study of predator\u2013prey system with defensive ability of prey and impulsive perturbations on the predator",
        "abstract": "Predator\u2013prey system with non-monotonic functional response and impulsive perturbations on the predator is established. By using Floquet theorem and small amplitude perturbation skills, a locally asymptotically stable prey-eradication periodic solution is obtained when the impulsive period is less than the critical value. Otherwise, if the impulsive period is larger than the critical value, the system is permanent. Further, using numerical simulation method the influences of the impulsive perturbations on the inherent oscillation are investigated. With the increasing of the impulsive value, the system displays a series of complex phenomena, which include (1) quasi-periodic oscillating, (2) period-doubling, (3) period-halfing, (4) non-unique dynamics (meaning that several attractors coexist), (5) attractor crisis and (6) chaotic bands with periodic windows.",
        "keywords": [
            "numerical simulation",
            "monotone function",
            "critical value",
            "oscillations"
        ],
        "authors": [
            {
                "name": "Shuwen Zhang",
                "org": ""
            },
            {
                "name": "Lingzhen Dong",
                "org": "Department of Mathematics, Taiyuan University of Technology, Shanxi, Taiyuan 030024, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Liaoning, Dalian 116024, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2005
    },
    "J8P2t0zx": {
        "id": "J8P2t0zx",
        "title": "A Holling II functional response food chain model with impulsive perturbations",
        "abstract": "In this paper, we investigate a three trophic level food chain system with Holling II functional responses and periodic constant impulsive perturbations of top predator. Conditions for extinction of predator as a pest are given. By using the Floquet theory of impulsive equation and small amplitude perturbation skills, we consider the local stability of predator eradication periodic solution. Further, influences of the impulsive perturbation on the inherent oscillation are studied numerically, which shows the rich dynamics (for example: period doubling, period halfing, chaos crisis) in the positive octant. The dynamics behavior is found to be very sensitive to the parameter values and initial value.",
        "keywords": [
            "oscillations",
            "food chain",
            "floquet theory",
            "trophic level",
            "functional response"
        ],
        "authors": [
            {
                "name": "Shuwen Zhang",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Liaoning, Dalian 116024, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2005
    },
    "qLttJJdb": {
        "id": "qLttJJdb",
        "title": "Global asymptotic stability in n-species nonautonomous Lotka--Volterra competitive systems with infinite delays",
        "abstract": "By means of Lyapunov functional, we have succeeded in establishing the global asymptotic stability of the positive solutions of a delayed n-species nonautonomous Lotka-Volterra type competitive system without dominating instantaneous negative feedbacks. As a corollary, we show that the global asymptotic stability of the positive solution is maintained provided that the delayed negative feedbacks dominate other interspecific interaction effects with delays and the mean delays are sufficiently small.",
        "keywords": [],
        "authors": [
            {
                "name": "Rui Xu",
                "org": "Department of Mathematics, Mechanical Engineering College, 97 Heping West Road, Shijiazhuang 050003, People's Republic of China"
            },
            {
                "name": "Mark A. J. Chaplain",
                "org": "Department of Mathematics, University of Dundee, Dundee, UK DD1 4HN"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academia Sinica, Beijing, 100080, People's Republic of China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2002
    },
    "SXcinh9P": {
        "id": "SXcinh9P",
        "title": "Complex dynamic behavior of three-species ecological model with impulse perturbations and seasonal disturbances",
        "abstract": "In this paper, on the basis of the theories and methods of ecology and ordinary differential equations, a three-species ecological model with allochthonous nutrient input, impulse perturbations and seasonal disturbances is studied analytically and numerically. Using mathematical theoretical analysis, we obtain the threshold expression of the release amount, allochthonous nutrient input and seasonal disturbances parameter under the condition of some species extinction and all species persistence, which in turn provide a theoretical basis for the numerical simulation. Numerical analysis indicates that the key factors for long-term dynamical behavior are impulse perturbation and allochthonous nutrient input with seasonal disturbances. Nonetheless, it should be stressed that the allochthonous nutrient input with seasonal disturbances can aggravate periodic oscillations and promote the emergence of chaos. And these results show that impulse perturbations cannot prevent the indirect effect on complex population dynamics caused by allochthonous nutrient input with seasonal disturbances, which further confirm that allochthonous nutrient input with seasonal disturbances can play an important role in population persistence and evolutionary. All these results are expected to be useful in the study of complex dynamics of ecosystems.",
        "keywords": [
            "mathematical theoretical analysis",
            "seasonal disturbances parameter",
            "population persistence",
            "complex population dynamic",
            "seasonal disturbance",
            "complex dynamic behavior",
            "numerical analysis",
            "allochthonous nutrient input",
            "three-species ecological model",
            "complex dynamic",
            "numerical simulation",
            "impulse perturbation",
            "stable",
            "impulse"
        ],
        "authors": [
            {
                "name": "Chuanjun Dai",
                "org": "School of Mathematics and Information Science, Wenzhou University, Wenzhou, Zhejiang, 325027, China"
            },
            {
                "name": "Min Zhao",
                "org": "School of Life and Environmental Science, Wenzhou University, Wenzhou, Zhejiang, 325027, China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academia Sinica, Beijing 100080, China"
            }
        ],
        "venue": "Mathematics and Computers in Simulation",
        "year": 2012
    },
    "0Ksjqp0v": {
        "id": "0Ksjqp0v",
        "title": "State-Dependent Pulse Vaccination and Therapeutic Strategy in an SI Epidemic Model with Nonlinear Incidence Rate.",
        "abstract": "In this paper, the state-dependent pulse vaccination and therapeutic strategy are considered in the control of the disease. A pulse system is built to model this process based on an SI ordinary differential equation model. At first, for the system neglecting the impulse effect, we give the classification of singular points. Then for the pulse system, by using the theory of the semicontinuous dynamic system, the dynamics is analyzed. Our analysis shows that the pulse system exhibits rich dynamics and the system has a unique order-1 homoclinic cycle, and by choosing  as the control parameter, the order-1 homoclinic cycle disappears and bifurcates an orbitally asymptotical stable order-1 periodic solution when  changes. Numerical simulations by maple 18 are carried out to illustrate the theoretical results.",
        "keywords": "",
        "authors": [
            {
                "name": "Kaiyuan Liu",
                "org": "College of Mathematics and Information Science, Anshan Normal University, Anshan 114016, China."
            },
            {
                "name": "Tongqian Zhang",
                "org": "State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology, Shandong University of Science and Technology, Qingdao 266590, China."
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, China."
            }
        ],
        "venue": "Computational and mathematical methods in medicine",
        "year": 2019
    },
    "ThDmcPeu": {
        "id": "ThDmcPeu",
        "title": "Homoclinic bifurcation of a ratio-dependent predator\u2013prey system with impulsive harvesting",
        "abstract": "In this paper, we investigate a ratio-dependent prey\u2013predator model with state-dependent impulsive harvesting where the prey growth rate is subject to a strong Allee effect. The existence of order-1 homoclinic cycle is obtained, and choosing \\(\\alpha \\) as a control parameter, the existence, uniqueness and stability of order-1 periodic solution of the system are discussed by means of the geometry theory of semi-continuous dynamic system. We also investigate that system exhibits the phenomenon of homoclinic bifurcation about parameter \\(\\alpha \\). Moreover, the numerical simulations are provided to show the main results. The used methods are intuitive to prove the existence of order-1 periodic solution and homoclinic bifurcation.",
        "keywords": [
            "Allee effect",
            " Successor function",
            " Order-1 periodic solution",
            " Order-1 homoclinic cycle",
            " Homoclinic bifurcation"
        ],
        "authors": [
            {
                "name": "Chunjin\u00a0Wei",
                "org": "Science College,Jimei University,Xiamen,People\u2019s Republic of China"
            },
            {
                "name": "Junnan\u00a0Liu",
                "org": "Science College,Jimei University,Xiamen,People\u2019s Republic of China"
            },
            {
                "name": "Lansun\u00a0Chen",
                "org": "Academy of Mathematics and System Sciences,Chinese Academy of Sciences,Beijing,People\u2019s Republic of China"
            }
        ],
        "venue": "Nonlinear Dynamics",
        "year": 2017
    },
    "zhmRR17r": {
        "id": "zhmRR17r",
        "title": "Modelling and simulation of a continuous process with feedback control and pulse feeding",
        "abstract": "This paper deals with feedback control of a microorganism continuous culture process with pulse dosage supply of substrate and removal of products. By the analysis of the dynamic properties and numerical simulation of the continuous process, the conditions are obtained for the existence and stability of positive period-1 solution of the system. It is also pointed out that there does not exist positive period-2 solution. The results simplify the choice of suitable operating conditions for continuous culture systems. It also gives the complete expression of the period of the positive period-1 solution, which provides the precise feeding period for a regularly continuous culture system to achieve the same stable output as a continuous culture system with feedback control in the same production environment.",
        "keywords": [
            "state impulsive",
            "continuous culture",
            "feedback control",
            "variable biomass yield",
            "numerical simulation",
            "operant conditioning"
        ],
        "authors": [
            {
                "name": "Yuan Tian",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "School of Mathematical Science, Dalian University of Technology, Dalian 116024, People\u2019s Republic of China"
            },
            {
                "name": "Andrzej Kasperski",
                "org": "Faculty of Mathematics, Computer Science and Econometrics, Bioinformatics Factory, University of Zielona Gora, Szafrana 4a, 65-516 Zielona Gora, Poland"
            }
        ],
        "venue": "Computers & Chemical Engineering",
        "year": 2010
    },
    "EUJxmcXl": {
        "id": "EUJxmcXl",
        "title": "Periodic Solutions of a Delayed Predator-Prey Model with Stage Structure for Prey",
        "abstract": "\n Abstract\n \u00a0\u00a0A periodic predator-prey model with stage structure for prey and time delays due to negative feedback and gestation of predator\n is proposed. By using Gaines and Mawhin\u2019s continuation theorem of coincidence degree theory, sufficient conditions are derived\n for the existence of positive periodic solutions to the proposed model. Numerical simulations are presented to illustrate\n the feasibility of our main result.\n ",
        "keywords": [
            "numerical simulation",
            "negative feedback"
        ],
        "authors": [
            {
                "name": "rui xu",
                "org": "Department of Mathematics,Institute of Shijiazhuang Mechanical Engineering,Shijiazhuang,China"
            },
            {
                "name": "Lan-sun Chen",
                "org": "Academy of Mathematics and Systems Science,CAS,Beijing,China"
            },
            {
                "name": "Fei-long Hao",
                "org": "Department of Mathematics,Institute of Shijiazhuang Mechanical Engineering,Shijiazhuang,China"
            }
        ],
        "venue": "Acta Mathematicae Applicatae Sinica-english Series",
        "year": 2004
    },
    "D1x40Vj2": {
        "id": "D1x40Vj2",
        "title": "Qualitative analysis of impulsive state feedback control to an algae-fish system with bistable property",
        "abstract": "A kind of consumer-resource system is proposed to describe the bidirectional interactions of the algae and the fish in an eutrophic water body. The dynamical properties of the proposed continuous system are given. For the bistable case, an impulsive semidynamical system with state feedback control, which depends on the biomass of the algae, is formulated and investigated to consider the feasibility of state feedback control for the aim of maintaining two species coexisting. The impulsive semidynamical system has three cases corresponding to three kinds of control measures: releasing fish, spraying algaecide, integrated control combining releasing fish and spraying algaecide. The existences of order-1 periodic solutions of three models are discussed by using successor function, respectively. The conditions under which the order-1 periodic solution is stable are given by using the Poincar\u00e9 map and the analogue of Poincar\u00e9 criterion. Mathematical results show that, for every one of three control strategies, there exists a range of control parameter in which the corresponding control is feasible. Finally, those mathematical results are verified by numerical simulations and the practical meanings are given.",
        "keywords": [],
        "authors": [
            {
                "name": "Hongjian Guo",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            },
            {
                "name": "Xinyu Song",
                "org": ""
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2015
    },
    "OyA92Bx4": {
        "id": "OyA92Bx4",
        "title": "Time-limited management strategies of a single-species with Allee effect",
        "abstract": "Two kinds of time-limited management strategies of a single-species with Allee effect, described by the impulsive differential equation with initial and boundary value conditions, are presented according to the initial density of the species. By means of the comparison principle and the methods of upper and lower solutions, boundary value problems of impulsive management models are discussed. According to the initial density of the species, there are two kinds of models: the model with impulsive release and the model with impulsive harvesting. The corresponding sufficient conditions under which the corresponding model has a solution or no solution are obtained. If the models have a solution, the corresponding management strategy can be performed successfully. For the model with impulsive release, if other parameters are given, the population of release can be estimated. For the model with impulsive harvesting, the times of impulsive harvesting can also be estimated. Finally, some discussions and corresponding numerical simulations about the results obtained in this paper are given. Copyright \u00a9 2008 Rocky Mountain Mathematics Consortium.",
        "keywords": [
            "Allee effect",
            "Boundary value problem",
            "Impulsive differential equation",
            "Impulsive effect",
            "Single species"
        ],
        "authors": [
            {
                "name": "Guo Hongjian",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            },
            {
                "name": "Chen Lansun",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            },
            {
                "name": "Song Xinyu",
                "org": "Xinyang Normal University(Xinyang Normal University),Xinyang,China"
            }
        ],
        "venue": "Rocky Mountain Journal of Mathematics",
        "year": 2008
    },
    "qYmSE3TD": {
        "id": "qYmSE3TD",
        "title": "Harvesting policy for a delayed stage-structured Holling II predator\u2013prey model with impulsive stocking prey",
        "abstract": "A predator\u2013prey model with a stage structure for the predator, which improves the assumption that each individual predator has the same ability to capture prey, is proposed by Wang et al. [Wang W, Mulone G, Salemi F, Salone V. Permanence and stability of a stage-structured predator\u2013prey model. J Math Anal Appl 2001;262:499\u2013528]. It is assumed that immature individuals and mature individuals of the predator are divided by a fixed age and that immature predators do not have the ability to attack prey. We do economic management behavior for Wang model [Wang et al., 2001] by continuous harvesting on predator and impulsive stocking on prey. Then, a delayed stage-structured Holling type II predator\u2013prey model with impulsive stocking prey and continuous harvesting predator is established. It is also assumed that the predating products of the predator is only to increase its bearing ability. We obtain the sufficient conditions of the global attractivity of predator-extinction boundary periodic solution and the permanence of the system. Our results show that the behavior of impulsive stocking prey plays an important role for the permanence of the system, and provide tactical basis for the biological resource management. Further, the numerical analysis is also inserted to illuminate the dynamics of the system.",
        "keywords": [
            "numerical analysis",
            "resource manager"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": ""
            },
            {
                "name": "Xinzhu Meng",
                "org": "College of Science, Shandong University of Science and Technology, Qingdao 266510, People\u2019s Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, People\u2019s Republic of China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2009
    },
    "Rg20dnnG": {
        "id": "Rg20dnnG",
        "title": "Dynamical behaviors of a trimolecular response model with\u00a0impulsive input",
        "abstract": "In the paper, we consider a trimolecular response model with impulsive input. Sufficient conditions for globally stable positive\n equilibrium point of the trimolecular response model with constant input are obtained. By impulsive differential theory, we\n obtain conditions for permanence of the trimolecular response model with impulsive input. By numerical analysis, we demonstrate\n complex phenomena such as limit cycles, periodic solutions, and chaos.",
        "keywords": [
            "Biochemical reaction",
            "Impulsive effect",
            "Permanent",
            "Bifurcation"
        ],
        "authors": [
            {
                "name": "Zuxiong Li",
                "org": "School of Mathematical Science, Dalian University of Technology, Dalian, 116024 P.R. China"
            },
            {
                "name": "Lansun Chen",
                "org": "School of Mathematical Science, Dalian University of Technology, Dalian, 116024 P.R. China"
            }
        ],
        "venue": "Nonlinear Dynamics",
        "year": 2010
    },
    "pDQCJoqg": {
        "id": "pDQCJoqg",
        "title": "Bifurcation of a three molecular saturated reaction with impulsive input",
        "abstract": "Although impulsive differential equations have become a widely concerned subject and a lot of models with impulsive effect have been studied in recent years, biochemical reaction models with impulsive input are rarely studied. In this paper, we consider an irreversible three molecular reaction model with impulsive input. By using the Floquet theorem and the method for the small parameter of impulsive differential equations, we obtain sufficient conditions for asymptotical stability and global stability of the given system. The existence of a positive periodic solution is also studied by the bifurcation theory. Further, we also show that our given conditions are right by numerical simulations.",
        "keywords": [
            "asymptotical stability",
            "biochemical reaction",
            "impulsive effect",
            "bifurcation",
            "numerical simulation",
            "bifurcation theory",
            "asymptotic stability"
        ],
        "authors": [
            {
                "name": "Zuxiong Li",
                "org": ""
            },
            {
                "name": "Zhong Zhao",
                "org": "Department of Mathematics, Huanghuai University, Zhumadian 463000, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "School of Mathematical Sciences, Dalian University of Technology, Dalian 116024, PR China"
            }
        ],
        "venue": "Nonlinear Analysis: Real World Applications",
        "year": 2011
    },
    "NmKzCVSN": {
        "id": "NmKzCVSN",
        "title": "Extinction and permanence of chemostat model with pulsed input in a polluted environment\u2606",
        "abstract": "",
        "keywords": [
            "chemostat model",
            "extinction",
            "permanence",
            "stability"
        ],
        "authors": [
            {
                "name": "Zhong Zhao",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            },
            {
                "name": "Xinyu Song",
                "org": ""
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2009
    },
    "uwd9Rg2i": {
        "id": "uwd9Rg2i",
        "title": "Universal modelling and qualitative analysis of an impulsive bioprocess",
        "abstract": "The work proves that in an impulsive bioprocess the stable oscillation period exists for any microorganisms \u2013 i.e. microorganisms of any characteristics of biomass yield and specific growth rate \u2013 pointing out the practical and scientific importance of the presented solution. Moreover, universal stability conditions of the impulsive bioprocess are presented. In order to obtain the universality of the solution, a sigmoid function is introduced for description of the biomass yield changes. Further, the universal mathematical model of the impulsive bioprocess is established, tested and discussed. This work shows among others that the impulsive bioprocess extends functionality of a simple continuous bioprocess providing in an easy way to control biomass concentration. The article also introduces a new objective function and then presents and discusses aspects of the impulsive bioprocess multi-criteria optimization. The analytical results presented in the work are validated by numerical simulations.",
        "keywords": [
            "sigmoid biomass yield",
            "bioprocess stability",
            "multi-criteria optimization",
            "impulsive bioprocess",
            "growth dynamics",
            "numerical simulation",
            "qualitative analysis",
            "objective function",
            "mathematical model",
            "oscillations"
        ],
        "authors": [
            {
                "name": "Kaibiao Sun",
                "org": "School of Control Science and Engineering, Dalian University of Technology, Dalian 116024, People's Republic of China"
            },
            {
                "name": "Yuan Tian",
                "org": "School of Mathematical Science, Dalian University of Technology, Dalian 116024, People's Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "School of Mathematical Science, Dalian University of Technology, Dalian 116024, People's Republic of China"
            },
            {
                "name": "Andrzej Kasperski",
                "org": ""
            }
        ],
        "venue": "Computers & Chemical Engineering",
        "year": 2011
    },
    "v2dOYp2j": {
        "id": "v2dOYp2j",
        "title": "Global Qualitative Analysis for a Ratio-Dependent Predator\u2013Prey Model with Delay",
        "abstract": "A ratio-dependent predator\u2013prey model with time lag for predator is proposed and analyzed. Mathematical analyses of the model equations with regard to boundedness of solutions, nature of equilibria, permanence, and stability are analyzed. We note that for a ratio-dependent system local asymptotic stability of the positive steady state does not even guarantee the so-called persistence of the system and, therefore, does not imply global asymptotic stability. It is found that an orbitally asymptotically stable periodic orbit exists in that model. Some sufficient conditions which guarantee the global stability of positive equilibrium are given.",
        "keywords": [
            "global stability",
            "delay",
            "competitive systems",
            "predator\u2013prey system",
            "qualitative analysis",
            "steady state",
            "asymptotic stability"
        ],
        "authors": [
            {
                "name": "Sanyi Tang",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Academia Sinica, Beijing, 100080, People's Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Academia Sinica, Beijing, 100080, People's Republic of China"
            }
        ],
        "venue": "Journal of Mathematical Analysis and Applications",
        "year": 2002
    },
    "Jfe09yrw": {
        "id": "Jfe09yrw",
        "title": "The geometrical analysis of a predator-prey model with two state impulses.",
        "abstract": "Using successor functions and Poincar\u00e9-Bendixson theorem of impulsive differential equations, the existence of periodical solutions to a predator-prey model with two state impulses is investigated. By stability theorem of periodic solution to impulsive differential equations, the stability conditions of periodic solutions to the system are given. Some simulations are exerted to prove the results.",
        "keywords": [
            "impulsive differential system",
            "periodic solution",
            "state impulse",
            "successor function"
        ],
        "authors": [
            {
                "name": "Lichun Zhao",
                "org": "Anshan Normal University(Anshan Normal University,Anshan Normal College),Anshan,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "Qingling Zhang",
                "org": "Northeastern University China(Northeastern University,Northeastern Univ.),Shenyang,China"
            }
        ],
        "venue": "Mathematical biosciences",
        "year": 2012
    },
    "4Czgu38g": {
        "id": "4Czgu38g",
        "title": "A stage structure pest management model with impulsive state feedback control",
        "abstract": "",
        "keywords": [
            "stability"
        ],
        "authors": [
            {
                "name": "guoping pang",
                "org": ""
            },
            {
                "name": "lansun chen",
                "org": ""
            },
            {
                "name": "weijian xu",
                "org": ""
            },
            {
                "name": "gang fu",
                "org": ""
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2015
    },
    "Vr9QKsOl": {
        "id": "Vr9QKsOl",
        "title": "Extinction and permanence in competitive stage structured system with time-delays",
        "abstract": "",
        "keywords": [
            "permanence",
            "time delays",
            "extinction",
            "stage structure",
            "competitive system",
            "competitive stage"
        ],
        "authors": [
            {
                "name": "Shengqiang Liu",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Academia Sinica, Beijing 100080, People's Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Academia Sinica, Beijing 100080, People's Republic of China"
            },
            {
                "name": "Guilie Luo",
                "org": "Department of Mathematics, Guangxi Normal University, Guilin 541004, People's Republic of China"
            }
        ],
        "venue": "Nonlinear Analysis: Theory, Methods & Applications",
        "year": 2002
    },
    "jFN7mX1o": {
        "id": "jFN7mX1o",
        "title": "Qualitative analysis of\u00a0a\u00a0variable yield turbidostat model with\u00a0impulsive state feedback control",
        "abstract": "A turbidostat is an apparatus with feedback control system used to continuously culturing microorganisms. The dilution rate of the turbidostat can be regulated by the control system when the concentration of microorganism, detected by photoelectricity system or other devices, reaches a preset value. Based on the design ideas of the turbidostat, a differential equation with impulsive state feedback control is proposed for a kind of turbidostat system in this paper. By the existence criteria of periodic solution of a general planar impulsive autonomous system, the conditions for the existence of periodic solution of order one are obtained according to the preset value and the types of the positive equilibrium of the corresponding system without impulsive control. Furthermore, it is pointed out that the system either tends to a stable state or has a periodic solution. Finally, the theoretical results are verified by numerical simulations. \u00a9 2009 Korean Society for Computational and Applied Mathematics.",
        "keywords": [
            "turbidostat \u00b7 microorganism \u00b7 continuous culture \u00b7 impulsive control \u00b7 periodic solution"
        ],
        "authors": [
            {
                "name": "Hongjian Guo",
                "org": "Xinyang Normal University College of Mathematics and Information Science Xinyang 464000 China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116024 China"
            }
        ],
        "venue": "Journal of Applied Mathematics and Computing",
        "year": 2010
    },
    "m9QulTBM": {
        "id": "m9QulTBM",
        "title": "Ultimate behavior of predator-prey system with constant harvesting of the prey impulsively",
        "abstract": "In this paper, we consider the Lotka-Volterra predator-prey system, in which constant quantity of the prey is harvested in\n regular pulses. The ultimate behavior of the solutions starting from different regions is mainly studied. Further, some examples\n are given to illustrate our results.",
        "keywords": [
            "extinc- tion",
            "boundedness.",
            "ultimate behavior",
            ": impulsive harvesting"
        ],
        "authors": [
            {
                "name": "Lingzhen Dong",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116023 Liaoning China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116023 Liaoning China"
            },
            {
                "name": "Lihua Sun",
                "org": ""
            },
            {
                "name": "Jianwen Jia",
                "org": ""
            }
        ],
        "venue": "Journal of Applied Mathematics and Computing",
        "year": 2006
    },
    "2ikjnrNy": {
        "id": "2ikjnrNy",
        "title": "Effects of habitat fragmentation and ecological invasion on population sizes",
        "abstract": "In this paper, we consider the effects of habitat fragmentation and ecological invasion of exotic species on the survival of a native endangered species, respectively. Different from the former studies, we pay attention on the more important situation in conservation biology that species live in a weak patchy environment in the sense that species in some of the isolated patches will become extinct without the contribution from other patches. We establish some fundamental permanence and extinction results on the basic and important nonautonomous diffusive Logistic model. In addition, by using these results, we consider the effect of an introduced species on the survival of a native species through competition. Biological implications of these results are discussed.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Jing'an Cui",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            }
        ],
        "venue": "Computers and Mathematics with Applications",
        "year": 1999
    },
    "VxoUBIVh": {
        "id": "VxoUBIVh",
        "title": "Mathematical modelling to control a pest population by infected pests",
        "abstract": "In this paper, we formulate and investigate the pest control models in accordance with the mathematical theory of epidemiology. We assume that the release of infected pests is continuous and impulsive, respectively. Therefore, our models are the ordinary differential equations and the impulsive differential equations. We study the global stability of the equilibria of the ordinary differential equations. The permanence of the impulsive differential equations is proved. By means of numerical simulation, we obtain the critical values of the control variable under different methods of release of infected pests. Thus, we provide a mathematical evidence in the management of an epidemic controlling a pest.",
        "keywords": [
            "Permanence",
            "Integrated Pest Management",
            "Globally asymptotic stability"
        ],
        "authors": [
            {
                "name": "Shulin Sun",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Liaoning, Dalian 116024, PR China"
            }
        ],
        "venue": "Applied Mathematical Modelling",
        "year": 2009
    },
    "moEZyz9P": {
        "id": "moEZyz9P",
        "title": "Two profitless delays for the SEIRS epidemic disease model with nonlinear incidence and pulse vaccination",
        "abstract": "A new SEIRS epidemic disease model with two profitless delays and nonlinear incidence are proposed, and the dynamic behaviors of the model under pulse vaccination are analyzed. Using the discrete dynamical system determined by the stroboscopic map, we show that there exists a \u2018infection-free\u2019 periodic solutions, further, we show that the \u2018infection-free\u2019 periodic solution is globally attractive when the period of impulsive effect is less than some critical value. Using a new modeling method, we obtain sufficient condition for the permanence of the epidemic model with pulse vaccination. We show that time delays, pulse vaccination and nonlinear incidence can bring different effects on the dynamic behaviors of the model by numerical analysis. Our results also show the delays are \u201cprofitless\u201d. In this paper, the main feature is to introduce two discrete time delays and impulse into SEIRS epidemic model and to give pulse vaccination strategies.",
        "keywords": [
            "global attractivity",
            "time delay",
            "permanence",
            "nonlinear incidence",
            "pulse vaccination",
            "critical value",
            "epidemic model",
            "discrete time",
            "numerical analysis"
        ],
        "authors": [
            {
                "name": "Xinzhu Meng",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Academia Sinica, Beijing 100080, PR China"
            },
            {
                "name": "Huidong Cheng",
                "org": "College of Science, Shandong University of Science and Technology, Qingdao 266510, PR China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2007
    },
    "I7jV0FVF": {
        "id": "I7jV0FVF",
        "title": "A Vertical Transmission DS-I-R Model with Vaccination for Recurrent Event Data",
        "abstract": "In this paper,we devote to investigate a vertical transmission DS-I-R model with vaccination,a threshold is obtained.Further,by using qualitative and stable theory of differential equation,sufficient conditions of local and global stability are derived for the disease free equilibrium and endemic equilibrium.",
        "keywords": [
            "disease free equilibrium",
            "global stability",
            "vaccination",
            "vertical transmission",
            "endemic equilibrium",
            "threshold"
        ],
        "authors": [
            {
                "name": "JIAO JIANJUN",
                "org": "Academy of Mathematics and System Sciences,Chinese Academy of Sciences,Beijing "
            },
            {
                "name": "CAI SHAOHONG",
                "org": "Academy of Mathematics and System Sciences,Chinese Academy of Sciences,Beijing "
            },
            {
                "name": "CHEN LANSUN",
                "org": "Academy of Mathematics and System Sciences,Chinese Academy of Sciences,Beijing "
            }
        ],
        "venue": "Acta Mathematicae Applicatae Sinica",
        "year": 2008
    },
    "F0JTmpVM": {
        "id": "F0JTmpVM",
        "title": "Impulsive selective harvesting in a logistic fishery model with time delay",
        "abstract": "In this work, we consider a logistic fishery model and discuss the selective impulsive harvesting of fish above a certain age or size by incorporating a time delay in the impulsive harvesting term. It is proved that there exists an asymptotically stable positive periodic solution x l1* (t) when the catchability coefficient h is less than some critical value hl*. It is concluded that hl* and xl1* are increasing with respect to l. Simulations shows that the delayed harvesting is advantageous to the sustainability of the population. \u00a9 World Scientific Publishing Company.",
        "keywords": [
            "delay",
            "global stability",
            "impulsive",
            "positive periodic solution",
            "selective harvesting"
        ],
        "authors": [
            {
                "name": "Yongzhen Pei",
                "org": "Tianjin Polytechnic University(Tianjin Polytechnic University),Tianjin,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            },
            {
                "name": "Changguo Li",
                "org": "Military Traffic Institute(Military Traffic Institute,Institute of Military Traffic),Tianjin,China"
            },
            {
                "name": "Chunhua Wang",
                "org": "Tianjin Polytechnic University(Tianjin Polytechnic University),Tianjin,China"
            }
        ],
        "venue": "Journal of Biological Systems",
        "year": 2006
    },
    "Wngt2q4i": {
        "id": "Wngt2q4i",
        "title": "Chaos in periodically forced Holling type IV predator\u2013prey system with impulsive perturbations",
        "abstract": "The effect of periodic forcing and impulsive perturbations on predator\u2013prey model with Holling type IV functional response is investigated. The periodic forcing is affected by assuming a periodic variation in the intrinsic growth rate of the prey. The impulsive perturbations are affected by introducing periodic constant impulsive immigration of predator. The dynamical behavior of the system is simulated and bifurcation diagrams are obtained for different parameters. The results show that periodic forcing and impulsive perturbation can easily give rise to complex dynamics, including (1) quasi-periodic oscillating, (2) period doubling cascade, (3) chaos, (4) period halfing cascade.",
        "keywords": [
            "complex dynamics",
            "functional response",
            "bifurcation diagram"
        ],
        "authors": [
            {
                "name": "Shuwen Zhang",
                "org": ""
            },
            {
                "name": "Dejun Tan",
                "org": "Institute of Biomathematics, Anshan Normal University, Liaoning, Anshan 114005, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Liaoning, Dalian 116024, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2006
    },
    "LEVZrSLq": {
        "id": "LEVZrSLq",
        "title": "Dynamical behaviors of a trimolecular response model with impulsive input",
        "abstract": "In the paper, we consider a trimolecular response model with impulsive input. Sufficient conditions for globally stable positive equilibrium point of the trimolecular response model with constant input are obtained. By impulsive differential theory, we obtain conditions for permanence of the trimolecular response model with impulsive input. By numerical analysis, we demonstrate complex phenomena such as limit cycles, periodic solutions, and chaos. \u00a9 2010 Springer Science+Business Media B.V.",
        "keywords": [
            "bifurcation",
            "biochemical reaction",
            "impulsive effect",
            "permanent",
            "equilibrium point",
            "numerical analysis",
            "limit cycle"
        ],
        "authors": [
            {
                "name": "Zuxiong Li",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            }
        ],
        "venue": "Nonlinear Dynamics",
        "year": 2010
    },
    "tnO4zYYZ": {
        "id": "tnO4zYYZ",
        "title": "IMPULSIVE CONTROL STRATEGIES FOR PEST MANAGEMENT",
        "abstract": "",
        "keywords": [
            "chemical pesticides",
            "epidemics",
            "impulsive control",
            "infective pests",
            "susceptible pests",
            "pest management"
        ],
        "authors": [
            {
                "name": "HONG ZHANG",
                "org": ""
            },
            {
                "name": "LANSUN CHEN",
                "org": ""
            },
            {
                "name": "PAUL GEORGESCU",
                "org": ""
            }
        ],
        "venue": "Journal of Biological Systems",
        "year": 2007
    },
    "kZ8XNQ6e": {
        "id": "kZ8XNQ6e",
        "title": "Positive periodic solution of a general discrete non-autonomous difference system of plankton allelopathy with delays",
        "abstract": "The main purpose of this paper is to investigate a discrete time non-autonomous difference system of plankton allelopathy with delays. By employing continuous theorem proposed by Gains and Mawhin and some new techniques, a set of verifiable sufficient criteria are established for the existence of at least one strictly positive (componentwise) periodic solution, and as an application, we also examine some special case, showing that these conditions are similar to those of continuous differential system. It is also shown that the time delays are harmless for the existence of positive periodic solutions of system.",
        "keywords": [
            "periodic solution",
            "special case",
            "general discrete non-autonomous difference",
            "positive periodic solution",
            "discrete time non-autonomous difference",
            "continuous differential system",
            "main purpose",
            "continuous theorem",
            "plankton allelopathy",
            "time delay",
            "new technique",
            "discrete time",
            "allelopathy"
        ],
        "authors": [
            {
                "name": "Zhijun Liu",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian, Liaoning, PR China and Department of Mathematics, Hubei Institute for Nationalities, Enshi, Hubei, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian, Liaoning, PR China and Institute of Mathematics, Academy of Mathematics and System Sciences, Academia Sinica, Beijing, P ..."
            }
        ],
        "venue": "Journal of Computational and Applied Mathematics",
        "year": 2006
    },
    "K63HnHjt": {
        "id": "K63HnHjt",
        "title": "Global attractivity and Permanence of a Stage-Structured pest Management Si Model with Time Delay and Diseased Pests impulsive Transmission",
        "abstract": "",
        "keywords": [
            "permanence",
            "pest management"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Advances in Complex Systems",
        "year": 2007
    },
    "rYStj2km": {
        "id": "rYStj2km",
        "title": "A Single Species Model with Impulsive Diffusion",
        "abstract": "\n Abstract\n \u00a0\u00a0In most models of population dynamics, diffusion between patches is assumed to be continuous or discrete, but in practice\n many species diffuse only during a single period. In this paper we propose a single species model with impulsive diffusion\n between two patches, which provides a more natural description of population dynamics. By using the discrete dynamical system\n generated by a monotone, concave map for the population, we prove that the map always has a globally stable positive fixed\n point. This means that a single species system with impulsive diffusion always has a globally stable positive periodic solution.\n This result is further substantiated by numerical simulation. Under impulsive diffusion the single species survives in the\n two patches.\n ",
        "keywords": [
            "boundedness",
            "stroboscopic map",
            "global stability",
            "monotone concave map",
            "impulsive diffusion",
            "positive fixed point"
        ],
        "authors": [
            {
                "name": "Jing Hui",
                "org": "East China Normal University Department of Mathematics Shanghai 200062 China Shanghai 200062 China"
            },
            {
                "name": "Lan-sun Chen",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian, 116024 China Dalian, 116024 China"
            }
        ],
        "venue": "Acta Mathematicae Applicatae Sinica-english Series",
        "year": 2005
    },
    "GP2Ook3F": {
        "id": "GP2Ook3F",
        "title": "Nonlinear incidence rate of a pest management SI model with biological and chemical control concern",
        "abstract": "A pest management S-I model with impulsive releases of infective pests and spraying pesticides is proposed and investigated.It was proved that all solutions of the model are uniformly ultimately bounded.The sufficient conditions of globally asymptotic stability periodic solution of pest-extinction and permanence of the model were also obtained.The approach of combining impulsive releasing infective pests with impulsive spraying pesticides provides reliable tactical basis for the practical pest management.",
        "keywords": [
            "infective",
            "pest-extinction",
            "impulsive",
            "chemical control",
            "incidence rate",
            "pest management"
        ],
        "authors": [
            {
                "name": "JIAO Jian-jun",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian , P. R. China"
            },
            {
                "name": "CHEN Lan-sun",
                "org": " School of Mathematics and Statistics, Guizhou College of Finance and Economics, Guiyang , P. R. China"
            }
        ],
        "venue": "Applied Mathematics and Mechanics-english Edition",
        "year": 2007
    },
    "PbFaghYj": {
        "id": "PbFaghYj",
        "title": "Profitless delays for a nonautonomous Lotka\u2013Volterra predator\u2013prey almost periodic system with dispersion",
        "abstract": "This paper studies a nonautonomous Lotka\u2013Volterra almost periodic predator\u2013prey dispersal system with discrete and continuous time delays which consists of two-patches, the prey species can disperse among two-patches, but the predator species is confined to one patch and cannot disperse. By using comparison theorem and delay differential equation basic theory, we prove the system is uniformly persistent under some appropriate conditions. Further, by constructing suitable Lyapunov functional, we show that the system is globally asymptotically stable under some appropriate conditions. By using a new method and almost periodic functional hull theory, we show that the almost periodic system has a unique globally asymptotical stable strictly positive almost periodic solution. The conditions for the permanence, global stability of system and the existence, uniqueness of positive almost periodic solution depend on delays, so, time delays are \u201cprofitless\u201d. Finally, ecological conclusions and a particular case are given. These results are basically an extension of the known results for nonautonomous Lotka\u2013Volterra systems.",
        "keywords": [
            "time delay",
            "hull",
            "globally asymptotic stability",
            "almost periodic solution",
            "dispersion",
            "lyapunov function",
            "almost periodic function",
            "delay differential equation"
        ],
        "authors": [
            {
                "name": "Xinzhu Meng",
                "org": ""
            },
            {
                "name": "Weijian Xu",
                "org": "Department of Mathematics and Computer Science, Yulin Teachers College, Yulin, Guangxi 537000, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Academia Sinica, Beijing 100080, PR China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2007
    },
    "16B2zIbd": {
        "id": "16B2zIbd",
        "title": "Continuous and impulsive harvesting strategies in a stage-structured predator-prey model with time delay",
        "abstract": "In this paper, the continuous and impulsive harvesting policies are considered in a predator-prey system with stage-structure. In the case in which a continuous harvesting is used, it is shown that the mature predator becomes extinct under appropriate conditions. In the case in which an impulsive harvesting is used, using the discrete dynamical system determined by the stroboscopic map, we obtain the mature predator-eradication periodic solution of the system which is globally attractive. The conditions of permanence are established by the method of comparison involving multiple Liapunov functions and auxiliary function. These results indicate that: a short period of pulse harvest is a sufficient condition for the eradication of the population; the impulsive harvest policy is more effective than the continuous one from eradicating predator point of view. Our results offer a more economical and safe strategy in controlling pest in contrast with biological control and chemical control. Furthermore, we give a summary of the dynamic behavior when the impulsive period takes values in different intervals. Finally, numerical results show that the impulsive system we considered has more complex dynamics including quasi-periodic oscillation and chaos.",
        "keywords": [
            "65n06",
            "permanence",
            "impulsive harvesting policy",
            "impulsive system",
            "65n12",
            "biological control",
            "extinction",
            "discrete dynamical system",
            "92d25",
            "continuous harvesting",
            "stage-structured predator-prey model",
            "impulsive harvesting strategy",
            "impulsive harvest policy",
            "chemical control",
            "harvest",
            "time delay",
            "impulsive harvesting",
            "stage-structure",
            "impulsive period",
            "predator-prey system",
            "complex dynamics"
        ],
        "authors": [
            {
                "name": "Yongzhen Pei",
                "org": ""
            },
            {
                "name": "Changguo Li",
                "org": ""
            },
            {
                "name": "Chen Lansun",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116023, China"
            }
        ],
        "venue": "Mathematics and Computers in Simulation",
        "year": 2009
    },
    "XXKs8cpX": {
        "id": "XXKs8cpX",
        "title": "Global asymptotic stability of periodic Lotka-Volterra systems with delays",
        "abstract": "",
        "keywords": [
            "periodic Lotka-Volterra system",
            "Global asymptotic stability",
            "Lyapunov function",
            "Persistence",
            "Delay",
            "Lotka\u2013Volterra system",
            "Positive periodic solution",
            "Competition",
            "global asymptotic stability"
        ],
        "authors": [
            {
                "name": "Zhidong Teng",
                "org": "xinjiang university"
            },
            {
                "name": "Lansun Chen",
                "org": "institute of mathematics"
            }
        ],
        "venue": "Nonlinear Analysis: Theory, Methods & Applications",
        "year": 2001
    },
    "XqqOnGTn": {
        "id": "XqqOnGTn",
        "title": "Research Article Stage-Structured Impulsive SI Model for Pest Management",
        "abstract": "An SI epidemic model with stage structure is investigated. In the model, impulsive bio- logical control is taken, that is, we release infected pests to the field at a fixed time pe- riodically. We get a sufficient condition for the global asymptotical stability of the pest- eradication periodic solution (0,0, \ufffd I(t)), and a condition for the permanence of the sys- tem. At last, a brief discussion shows that our results will be helpful for pest management. Copyright \u00a9 2007 R. Shi and L. Chen. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.",
        "keywords": [
            "pest management",
            "epidemic model"
        ],
        "authors": [
            {
                "name": "Ruiqing Shi",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2007
    },
    "0aSTZAaw": {
        "id": "0aSTZAaw",
        "title": "Dynamic analysis of a pest-epidemic model with impulsive control",
        "abstract": "Based on biological control strategy in pest management, we construct and investigate a pest-epidemic model with impulsive control, i.e., periodic spraying microbial pesticide and releasing infected pests at different fixed moments. By using Floquet theorem and comparison theorem, we prove that the pest-eradication periodic solution is globally asymptotically stable when the impulsive period @t is less than the critical value @t\"m\"a\"x\"@?. Otherwise, the system can be permanent. Moreover, numerical results clearly show with the increase of the impulsive period @t, the system exhibits a wide variety of dynamic behaviors including a sequence of direct and inverse cascade of periodic-doubling, symmetry-breaking pitchfork bifurcation, chaos and non-unique dynamics, which implies that the impulsive effect makes the dynamic behavior of the system more complex.",
        "keywords": [
            "floquet theorem",
            "permanence",
            "pest-epidemic model",
            "asymptotically stable",
            "extinction",
            "dynamic behavior",
            "impulsive control",
            "non-unique dynamic",
            "pest-eradication periodic solution",
            "impulsive effect",
            "dynamic analysis",
            "comparison theorem",
            "chaos",
            "biological control strategy",
            "impulsive period",
            "symmetry breaking",
            "critical value",
            "epidemic model",
            "pest management",
            "biological control"
        ],
        "authors": [
            {
                "name": "Guoping Pang",
                "org": "Department of Mathematics and Computer Science, Yulin Normal University, Yulin Guangxi 537000, PR China and Department of Applied Mathematics, Dalian University of Technology, Dalian Liaoning 1160 ..."
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian Liaoning 116024, PR China"
            }
        ],
        "venue": "Mathematics and Computers in Simulation",
        "year": 2008
    },
    "766OFRUX": {
        "id": "766OFRUX",
        "title": "Nonlinear modelling of a synchronized chemostat with impulsive state feedback control",
        "abstract": "Bioreactor control is an active area of research on continuous microorganism cultivation. Control of the substrate concentration in the bioreactor medium is especially necessary because of the substrate inhibition phenomenon. Moreover in order to maintain the dissolved oxygen content in an appropriate range, the biomass concentration should not exceed a set level. To maintain the biomass concentration in the desired range the universal mathematical model of a continuous bioprocess with impulsive state feedback control is formulated in the article. By discussing the dynamic properties of the model including the existence and stability of the periodic solution, the choice of suitable operating conditions for continuous culture systems can be simplified, offering the possibility of establishing general and more systematic operations and control strategies based on the counteraction of the mechanisms underlying the adverse effects of the bioreactor dynamics. The article also presents and discusses aspects of the bioprocess optimization.",
        "keywords": [
            "state impulsive",
            "impulsive state feedback control",
            "nonlinear biomass yield",
            "continuous microorganism cultivation",
            "appropriate range",
            "continuous culture",
            "feedback control",
            "bioreactor control",
            "continuous culture system",
            "continuous bioprocess",
            "bioprocess optimization",
            "substrate concentration",
            "biomass concentration",
            "optimization",
            "control strategy",
            "nonlinear modelling",
            "dissolved oxygen",
            "adverse effect",
            "operant conditioning",
            "mathematical model"
        ],
        "authors": [
            {
                "name": "Kaibiao Sun",
                "org": "School of Control Science and Engineering, Dalian University of Technology, Dalian 116024, People's Republic of China"
            },
            {
                "name": "Yuan Tian",
                "org": "School of Information Engineering, Dalian University, Dalian 116622, People's Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "School of Mathematical Science, Dalian University of Technology, Dalian 116024, People's Republic of China"
            },
            {
                "name": "Andrzej Kasperski",
                "org": "Faculty of Mathematics, Computer Science and Econometrics, Bioinformatics Factory, University of Zielona Gora, Szafrana 4a, 65-516 Zielona Gora, Poland"
            }
        ],
        "venue": "Mathematical and Computer Modelling",
        "year": 2010
    },
    "HWACLoU9": {
        "id": "HWACLoU9",
        "title": "Staged-structured Lotka\u2013Volterra predator\u2013prey models for pest management",
        "abstract": "In this paper, two predator\u2013prey models with stage structure are constructed and investigated. In the first model, continuous biological control is taken. The existence and local stability of two equilibriums are studied. By the Liapunov stability theorem, we obtain the condition for the global asymptotical stability of the trivial equilibrium (i.e., pest-eradication equilibrium). In the second model, impulsive biological control is taken. By use of the Floquet\u2019s theorem, small-amplitude perturbation method and comparison techniques, we get the condition which guarantees the global asymptotical stability of the pest-eradication periodic solution. The sufficient condition for the permanence of the impulsive system is also obtained.",
        "keywords": [
            "pest-eradication periodic solution",
            "biological control",
            "pest-eradication equilibrium",
            "impulsive",
            "stage structured",
            "pest management"
        ],
        "authors": [
            {
                "name": "Ruiqing Shi",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, People\u2019s Republic of China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2008
    },
    "wFu155Xf": {
        "id": "wFu155Xf",
        "title": "Periodic solution of a turbidostat model with impulsive state feedback control",
        "abstract": "In this paper, a turbidostat model with impulsive state feedback control is considered. We obtain sufficient conditions of\n the global asymptotical stability of the system without impulsive state feedback control. We also obtain that the system with\n impulsive state feedback control may have order one periodic solution, and the sufficient condition for existence and stability\n of order one periodic solution is gotten as well. For some special cases, it is shown that in the system an order two periodic\n solution may exist. Our results show that the control measure is effective and reliable.",
        "keywords": [
            "Turbidostat",
            "Impulsive effect",
            "State feedback control",
            "Globally asymptotical stability",
            "Periodic solution"
        ],
        "authors": [
            {
                "name": "Zuxiong Li",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116024 People\u2019s Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116024 People\u2019s Republic of China"
            }
        ],
        "venue": "Nonlinear Dynamics",
        "year": 2009
    },
    "EaxITaHj": {
        "id": "EaxITaHj",
        "title": "Complex dynamics of a chemostat with variable yield and periodically impulsive perturbation on the substrate",
        "abstract": "In this paper, we consider the dynamic behaviors of a mathematical chemostat model with variable yield and periodically impulsive\n perturbation on the substrate. The microbial growth rate is the Monod function $${\\frac{\\mu S}{a+S}}$$ and the variable yield coefficient \u03b4(S) is quadratic (1\u00a0+\u00a0cS\n 2). Using Floquet theory and small amplitude perturbation method, we establish the condition under which the boundary periodic\n solution is globally asymptotically stable. Moreover, the permanence of the system is discussed in detail. Finally, by means\n of numerical simulation, we demonstrate that with the increasing of the pulsed substrate in the feed the system exhibits the\n complex dynamics.\n ",
        "keywords": [
            "variable yield",
            "chaotic attractor",
            "periodically pulsed substrate",
            "permanence",
            "complex dynamics",
            "numerical simulation",
            "microbial growth",
            "floquet theory"
        ],
        "authors": [
            {
                "name": "Shulin Sun",
                "org": "Shanxi Normal University School of Mathematics and Computer Science Shanxi Linfen 041004 Peoples Republic of china"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology Department of Applied Mathematics Liaoning Dalian 116024 Peoples Republic of china"
            }
        ],
        "venue": "Journal of Mathematical Chemistry",
        "year": 2008
    },
    "8jjUqIQg": {
        "id": "8jjUqIQg",
        "title": "Global dynamics of the periodic logistic system with periodic impulsive perturbations",
        "abstract": "This paper studies the global behaviors of the periodic logistic system with periodic impulsive perturbations. The results of D.D. Bainov and P.S. Simeonov\u00a0(1993) are extended and dynamics different from the corresponding continuous system are found. It is shown that the system may have a unique positive periodic solution which is globally asymptotically stable, or go extinct when the two periods are rational dependent. When they are rational independent, the system has no periodic solutions, however, still has a global attractor or go extinct under some conditions.",
        "keywords": [
            "extinction",
            "logistic system",
            "global asymptotical stability",
            "impulsive perturbation"
        ],
        "authors": [
            {
                "name": "Xianning Liu",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics & System Sciences, Academia Sinica, Beijing, 100080, PR China"
            }
        ],
        "venue": "Journal of Mathematical Analysis and Applications",
        "year": 2004
    },
    "fClkN73o": {
        "id": "fClkN73o",
        "title": "Multiple attractors in stage-structured population models with birth pulses.",
        "abstract": "In most models of population dynamics, increases in population due to birth are assumed to be time-independent, but many species reproduce only during a single period of the year. A single species stage-structured model with density-dependent maturation rate and birth pulse is formulated. Using the discrete dynamical system determined by its Poincar\u00e9 map, we report a detailed study of the various dynamics, including (a) existence and stability of nonnegative equilibria, (b) nonunique dynamics, meaning that several attractors coexist, (c) basins of attraction (defined as the set of the initial conditions leading to a certain type of attractor), (d) supertransients, and (e) chaotic attractors. The occurrence of these complex dynamic behaviour is related to the fact that minor changes in parameter or initial values can strikingly change the dynamic behaviours of system. Further, it is shown that periodic birth pulse, in effect, provides a natural period or cyclicity that allows multiple oscillatory solutions in the continuous dynamical systems.",
        "keywords": [
            "Bifurcation Diagram",
            "Chaotic Attractor",
            "Vital Rate",
            "Impulsive Differential Equation",
            "Discrete Dynamical System"
        ],
        "authors": [
            {
                "name": "Sanyi Tang",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Academia Sinica, Beijing 100080, People's Republic of China"
            }
        ],
        "venue": "Bulletin of mathematical biology",
        "year": 2003
    },
    "fbt4L7jp": {
        "id": "fbt4L7jp",
        "title": "Pest management through continuous and impulsive control strategies.",
        "abstract": "In this paper, we propose two mathematical models concerning continuous and, respectively, impulsive pest control strategies. In the case in which a continuous control is used, it is shown that the model admits a globally asymptotically stable positive equilibrium under appropriate conditions which involve parameter estimations. As a result, the global asymptotic stability of the unique positive equilibrium is used to establish a procedure to maintain the pests at an acceptably low level in the long term. In the case in which an impulsive control is used, it is observed that there exists a globally asymptotically stable susceptible pest-eradication periodic solution on condition that the amount of infective pests released periodically is larger than some critical value. When the amount of infective pests released is less than this critical value, the system is shown to be permanent, which implies that the trivial susceptible pest-eradication solution loses its stability. Further, the existence of a nontrivial periodic solution is also studied by means of numerical simulation. Finally, the efficiency of continuous and impulsive control policies is compared.",
        "keywords": [
            "extinction",
            "permanence",
            "infective pests",
            "continuous control",
            "impulsive control",
            "epidemics",
            "susceptible pests",
            "pest management",
            "critical value",
            "numerical simulation",
            "pest control",
            "mathematical model",
            "parameter estimation"
        ],
        "authors": [
            {
                "name": "Hong Zhang",
                "org": ""
            },
            {
                "name": "Jianjun Jiao",
                "org": "School of Mathematics and Statistics, Guizhou College of Finance and Economics, Guiyang, GuiZhou 550004, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, DaLian, LiaoNing 116024, PR China"
            }
        ],
        "venue": "BioSystems",
        "year": 2007
    },
    "gtr7MqX1": {
        "id": "gtr7MqX1",
        "title": "Permanence, extinction and balancing survival in nonautonomous Lotka--Volterra system with delays",
        "abstract": "In this paper, the periodic n-species Lotka-Volterra competition systems with time delays are considered. The sufficient conditions are derived for the permanence, extinction and balancing survival of the system. Some known results are improved and unified. Further, our results suggest that under some conditions, the introduction and the variance of the time delays will be either harmless or \"useless\". Conjecture about the effect of time delays on some global behaviors of the system is advanced.",
        "keywords": [],
        "authors": [
            {
                "name": "Shengqiang Liu",
                "org": "Institute of Mathematics, Academia Sinica, Beijing 100080, People's Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academia Sinica, Beijing 100080, People's Republic of China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2002
    },
    "egu43PjL": {
        "id": "egu43PjL",
        "title": "Nonlinear analysis of a microbial pesticide model with\u00a0impulsive\u00a0state feedback control",
        "abstract": "In this paper, a new mathematical model for the entomopathogenic nematode attacking pests with impulsive state feedback control is considered. By using the Poincar\u00e9 map, we obtain that the system with impulsive state feedback control has a periodic solution of order one. Sufficient conditions for existence and stability of the order one periodic solution are given. Specifically, the system has a singular order one periodic solution. In some cases, it is possible that the system may also have an order two periodic solution. Our results show that the control measure is effective and reliable. \u00a9 2010 Springer Science+Business Media B.V.",
        "keywords": [
            "Entomopathogenic nematode",
            "Impulsive effect",
            "State feedback control",
            "Poincar\u00e9 map",
            "Singular periodic solution"
        ],
        "authors": [
            {
                "name": "Tieying Wang",
                "org": "School of Mathematical Sciences, Dalian University of Technology, 116024 Dalian, P.R. China"
            },
            {
                "name": "Lansun Chen",
                "org": "School of Mathematical Sciences, Dalian University of Technology, 116024 Dalian, P.R. China"
            }
        ],
        "venue": "Nonlinear Dynamics",
        "year": 2011
    },
    "11ejnzL5": {
        "id": "11ejnzL5",
        "title": "Necessary-sufficient conditions for permanence and extinction in lotka-volterra system with distributed delays",
        "abstract": "In this paper, the necessary and sufficient conditions for permanence and extinction of the autonomous two-species Lotka-Volterra system with distributed delays are given. Some previous results are improved and extended. Moreover, it is shown in our paper that the permanence and extinction of the distributed-delayed system is equivalent to that of its nondelayed system.",
        "keywords": [
            "extinction",
            "permanence"
        ],
        "authors": [
            {
                "name": "Shengqiang Liu",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics Academy of Mathematics and System Sciences Academia Sinica, Beijing, 100080, P.R. China"
            }
        ],
        "venue": "Appl. Math. Lett.",
        "year": 2003
    },
    "OSP5SQhl": {
        "id": "OSP5SQhl",
        "title": "A discrete predator-prey system with age-structure for predator and natural barriers for prey",
        "abstract": "We analyze a two species discrete predator-prey model in which the prey disperses between two patches of a heterogeneous environment with barriers and the mature predator disperses between the patches with no barrier. By using the discrete dynamical system generated by a monotone, concave maps for subcommunity of prey, we obtain the subcommunity of prey exists an equilibrium which attracts all positive solutions, and using the stability trichotomy results on the monotone and continuous operator, we obtain some sufficient conditions for the permanence of species. These results are applied to the models with rational growth functions and exponential growth functions. We also present numerical examples to illustrate the dynamic complexity of systems.",
        "keywords": [
            "age-structure",
            "natural barrier",
            "persistence",
            "subcommunity",
            "age structure",
            "exponential growth"
        ],
        "authors": [
            {
                "name": "Sanyi Tang",
                "org": "Academy of Mathematics and System Sciences Chinese Academy of Sciences(Chinese Academy of Sciences,Academy of Mathematics and Systems Science),Beijing,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and System Sciences Chinese Academy of Sciences(Chinese Academy of Sciences,Academy of Mathematics and Systems Science),Beijing,China"
            }
        ],
        "venue": "Mathematical Modelling and Numerical Analysis",
        "year": 2001
    },
    "3PKQlFgR": {
        "id": "3PKQlFgR",
        "title": "Profitless delays for extinction in nonautonomous Lotka-Volterra system",
        "abstract": "",
        "keywords": [
            "competitive",
            "extinction",
            "lotka-volterra system",
            "periodic",
            "profitless delays"
        ],
        "authors": [
            {
                "name": "shengqiang liu",
                "org": ""
            },
            {
                "name": "lansun chen",
                "org": ""
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2001
    },
    "ig4NHdUk": {
        "id": "ig4NHdUk",
        "title": "Global Attractivity of Nonautonomous Inshore-Offshore Fishing Models with Stage-structure",
        "abstract": "",
        "keywords": [
            "dynamic system",
            "monotone",
            "stability"
        ],
        "authors": [
            {
                "name": "Lu Zhonghua",
                "org": ""
            },
            {
                "name": "Chen Lansun",
                "org": ""
            }
        ],
        "venue": "Applicable Analysis",
        "year": 2002
    },
    "KKWHVK2x": {
        "id": "KKWHVK2x",
        "title": "Bifurcation of nontrivial periodic solutions for a biochemical model with impulsive perturbations",
        "abstract": "In this paper, a biochemical model with the impulsive perturbations is considered. By using the Floquet theorem, we find the boundary-periodic solution is asymptotically stable if the impulsive period is larger than a critical value. On the contrary, it is unstable if the impulsive period is less than the critical value. The problem of finding nontrivial periodic solutions is reduced to showing the existence of the nontrivial fixed points for the associated stroboscopic mapping of time snapshot equal to the common period of input. It is then shown that once a threshold condition is reached, a stable nontrivial periodic solution emerges via a supercritical bifurcation. Furthermore, influences of the impulsive input on the inherent oscillations are studied numerically, which shows the rich dynamics in the positive octant.",
        "keywords": [
            "asymptotical stability",
            "chaos",
            "bifurcation",
            "nontrivial periodic solutions",
            "oscillations",
            "critical value",
            "asymptotic stability",
            "fixed point"
        ],
        "authors": [
            {
                "name": "Zhong Zhao",
                "org": ""
            },
            {
                "name": "Li Yang",
                "org": "Department of Mathematics, Huanghuai University, Zhumadian 463000, Henan, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, PR China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2009
    },
    "GzvNrPZe": {
        "id": "GzvNrPZe",
        "title": "A impulsive infective transmission SI model for pest control",
        "abstract": "",
        "keywords": [
            "epidemics",
            "extinction and permanence",
            "impulsive control",
            "infective pests",
            "susceptible pests",
            "pest control"
        ],
        "authors": [
            {
                "name": "Hong Zhang",
                "org": ""
            },
            {
                "name": "Weijian Xu",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Mathematical Methods in The Applied Sciences",
        "year": 2007
    },
    "EOR8Ur3o": {
        "id": "EOR8Ur3o",
        "title": "Analysis of a SIS epidemic model with stage structure and a delay",
        "abstract": "",
        "keywords": [
            "delay",
            "globally asymptotically stable",
            "sis epidemic model",
            "threshold",
            "difference equation",
            "epidemic model"
        ],
        "authors": [
            {
                "name": "yanni xiao",
                "org": ""
            },
            {
                "name": "lansun chen",
                "org": ""
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2001
    },
    "cQB8f5Iz": {
        "id": "cQB8f5Iz",
        "title": "Periodic solution of a two-species competitive system with toxicant and birth pulse",
        "abstract": "In this paper, we study the existence of positive periodic solution of two-species competitive system with toxicant and birth pulse. A set of easily verifiable sufficient conditions are derived for the existence of at least one positive periodic solution of the above system by using the method of coincidence degree. Numerical simulations are also presented to illustrate the feasibility of our main results.",
        "keywords": [
            "numerical simulation"
        ],
        "authors": [
            {
                "name": "Zhijun Liu",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, 116024 Dalian Liaoning, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2007
    },
    "9zXVwTAY": {
        "id": "9zXVwTAY",
        "title": "On the stable periodic solutions of a delayed two-species model of facultative mutualism",
        "abstract": "Inspired by a delayed single-species population growth model with so-called hereditary effect, we propose a delayed two-species system modelling \u201cfacultative mutualism\u201d in this paper. Easily verifiable sufficient conditions are derived for the existence and globally asymptotic stability of positive periodic solutions of system by employing some analysis techniques and Lyapunov functional. Later, we extend the above results to a more general two-species facultative mutualism system involving multiple delays. Some previous results are extended and improved. Biological interpretations on the main results are also given.",
        "keywords": [
            "lyapunov functional",
            "continuation theorem",
            "delay",
            "globally asymptotic stability",
            "facultative mutualism",
            "periodic solution",
            "lyapunov function",
            "population growth"
        ],
        "authors": [
            {
                "name": "Zhijun Liu",
                "org": ""
            },
            {
                "name": "Ronghua Tan",
                "org": "Department of Mathematics, Hubei Institute for Nationalities, Enshi, Hubei 445000, PR China"
            },
            {
                "name": "Yiping Chen",
                "org": "Department of Mathematics, Hubei Institute for Nationalities, Enshi, Hubei 445000, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian, Liaoning 116024, PR China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2008
    },
    "fFdiTFRc": {
        "id": "fFdiTFRc",
        "title": "Permanence and complexity of a three species food chain with impulsive effect on the top predator",
        "abstract": "In this paper, we investigate a three species food chain with periodic impulsive effect on the top predator. Using the Floquet theory and small amplitude perturbation skills, we show that there exists a globally asymptotically stable mid-level predator-eradication periodic solution when the impulsive period is less than some critical value. Further, we prove that the system is permanent if the impulsive period is larger than some critical value. Finally, numerical simulation shows that with increasing of the impulsive value, the system experiences a complex process of (1) cycles, (2) periodic doubling, (3)periodic halfing and (4) chaotic bands with periodic windows. \u00a9 Freund Publishing House Ltd.",
        "keywords": [
            "chaos",
            "food chain",
            "impulsive effect",
            "permanence"
        ],
        "authors": [
            {
                "name": "Fengyan Wang",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            },
            {
                "name": "Shuwen Zhang",
                "org": "Anshan Normal University(Anshan Normal University,Anshan Normal College),Anshan,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            },
            {
                "name": "LiHua Sun",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            }
        ],
        "venue": "International Journal of Nonlinear Sciences and Numerical Simulation",
        "year": 2005
    },
    "BKsZlT0I": {
        "id": "BKsZlT0I",
        "title": "Dynamical behaviors of a biological management model with impulsive stocking juvenile predators and continuous harvesting adult predators",
        "abstract": "In this work, a biological management model with impulsive stocking juvenile predators and continuous harvesting adult predators is investigated. By the stroboscopic map of the discrete dynamical system, the prey-extinction periodic solution of the investigated system is proved to be globally asymptotically stable. By the theory of impulsive differential equation, the investigated system is also proved to be permanent. Finally, the numerical analysis is inserted to illustrate the results. Our conclusions provide reliable tactical basis for the practical biological management. \u00a9 2010 Korean Society for Computational and Applied Mathematics.",
        "keywords": [
            "continuous harvesting",
            "extinction",
            "impulsive stocking",
            "permanent",
            "predator-prey model",
            "numerical analysis"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": "Guizhou College of Finance and Economics(Guizhou College of Finance and Economics),Guiyang,China"
            },
            {
                "name": "Shaohong Cai",
                "org": "Guizhou College of Finance and Economics(Guizhou College of Finance and Economics),Guiyang,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and System Sciences Chinese Academy of Sciences(Chinese Academy of Sciences,Academy of Mathematics and Systems Science),Beijing,China"
            }
        ],
        "venue": "Journal of Applied Mathematics and Computing",
        "year": 2011
    },
    "BKq1An84": {
        "id": "BKq1An84",
        "title": "Global Stability for a Generalized Predator-Prey System with Time Delay in Two-patch Environments",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Rui Xu",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Applicable Analysis",
        "year": 2003
    },
    "6ksaXwaK": {
        "id": "6ksaXwaK",
        "title": "Dynamic complexity of a two-prey one-predator system with impulsive effect",
        "abstract": "In this paper, we investigate the dynamic complexity of a two-prey one-predator system with impulsive perturbation on predator at fixed moments. With the increase of the predation rate for the super competitor, the system displays complicated phenomena including a sequence of direct and inverse cascade of periodic-doubling, chaos, and symmetry breaking bifurcation. Moreover, we discuss the effect of the period of releasing predator on the dynamical behaviors of the unforced continuous system, and find that periodically releasing predator at fixed moments change the properties of the unforced continuous system. We suggest a highly effective method in pest control. The target pest population can be driven to extinction and the non-target pest (or harmless insect) can be permanent by choosing impulsive period, while classical method cannot emulate.",
        "keywords": [
            "pest control",
            "symmetry breaking"
        ],
        "authors": [
            {
                "name": "Yujuan Zhang",
                "org": ""
            },
            {
                "name": "Zhilong Xiu",
                "org": "Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian, Liaoning 116024, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Academia Sinia, Beijing 100080, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2005
    },
    "ITIH8bAL": {
        "id": "ITIH8bAL",
        "title": "On the impulsive controllability and bifurcation of a predator-pest model of IPM.",
        "abstract": "From a practical point of view, the most efficient strategy for pest control is to combine an array of techniques to control the wide variety of potential pests that may threaten crops in an approach known as integrated pest management (IPM). In this paper, we propose a predator-prey (pest) model of IPM in which pests are impulsively controlled by means of spraying pesticides (the chemical control) and releasing natural predators (the biological control). It is assumed that the biological and chemical control are used with the same periodicity, but not simultaneously. The functional response of the predator is allowed to be predator-dependent, in the form of a Beddington-DeAngelis functional response, rather than to have a perhaps more classical prey-only dependence. The local and global stability of the pest-eradication periodic solution, as well as the permanence of the system, are obtained under integral conditions which are shown to have biological significance. In a certain limiting case, it is shown that a nontrivial periodic solution emerges via a supercritical bifurcation. Finally, our findings are confirmed by means of numerical simulations.",
        "keywords": [
            "beddington\u2013deangelis functional response",
            "pest-eradication periodic solution",
            "permanence",
            "economic threshold",
            "impulsive controls",
            "supercritical bifurcation",
            "beddington-deangelis functional response",
            "stability analysis",
            "fixed point approach",
            "integrated pest management",
            "pest control",
            "biological control",
            "fixed point",
            "functional response",
            "numerical simulation"
        ],
        "authors": [
            {
                "name": "Hong Zhang",
                "org": ""
            },
            {
                "name": "Paul Georgescu",
                "org": "Department of Mathematics, \u201cGh. Asachi\u201d Technical University of Ia\u015fi, Bd. Copou 11, 700506 Ia\u015fi, Romania"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academia Sinica, Beijing 100080, PR China"
            }
        ],
        "venue": "BioSystems",
        "year": 2008
    },
    "cxYptSDT": {
        "id": "cxYptSDT",
        "title": "New Approach to the Nonlinear Analysis of a Chemostat with Impulsive State Feedback Control",
        "abstract": "",
        "keywords": [
            "chemostat optimization",
            "feedback control",
            "growth dynamics",
            "optimization",
            "stability"
        ],
        "authors": [
            {
                "name": "Kaibiao Sun",
                "org": ""
            },
            {
                "name": "Andrzej Kasperski",
                "org": ""
            },
            {
                "name": "Yuan Tian",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "International Journal of Chemical Reactor Engineering",
        "year": 2010
    },
    "Hb5FLmOP": {
        "id": "Hb5FLmOP",
        "title": "Dynamic Complexities in an Epidemic Model with Birth Pulses and Pulse Culling",
        "abstract": "",
        "keywords": [
            "Birth pulse",
            "Chaos",
            "Epidemic model",
            "Period-doubling bifurcation",
            "Period-halving bifurcation",
            "Pulse culling"
        ],
        "authors": [
            {
                "name": "Shujing Gao",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            },
            {
                "name": "Zhidong Teng",
                "org": ""
            },
            {
                "name": "Dehui Xie",
                "org": ""
            }
        ],
        "venue": "I. J. Bifurcation and Chaos",
        "year": 2007
    },
    "DMmmMloK": {
        "id": "DMmmMloK",
        "title": "Persistence and global stability in a delayed predator-prey system with Holling-type functional response",
        "abstract": "A delayed predator-prey system with Holling type III functional response is investigated. It is proved that the system is uniformly persistent under some appropriate conditions. By means of suitable Lyapunov functionals, sufficient conditions are derived for the local and global asymptotic stability of a positive equilibrium of the system. Numerical simulations are presented to illustrate the feasibility of our main results.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Rui Xu",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics|Academia Sinica"
            },
            {
                "name": "M. A. J. Chaplain",
                "org": "Department of Mathematics|University of Dundee"
            }
        ],
        "venue": "Anziam Journal",
        "year": 2004
    },
    "fbU2w0mI": {
        "id": "fbU2w0mI",
        "title": "An Ivlev's functional response predator-prey model with time delay and impulsive perturbations on predators",
        "abstract": "An Ivlev's functional response stage-structured predator-prey model with time delay and impulsive perturbations on predators is proposed and analyzed. By using comparative theorem of impulsive differential equation and delay differential equation basic theory, sufficient conditions which guarantee the global attraction of pest-extinction periodic solution and permanence of the system are obtained. And all solutions of the system are uniformly and ultimately bounded. These results are basically extension of the known results and models, and provide reliable tactic basis for the practical pest management.",
        "keywords": [
            "Global attraction",
            "Impulsive perturbation",
            "Permanence",
            "Stage-structure"
        ],
        "authors": [
            {
                "name": "LIU Kai-yuan",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            },
            {
                "name": "CHEN Lan-sun",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            }
        ],
        "venue": "Dalian Ligong Daxue Xuebao/Journal of Dalian University of Technology",
        "year": 2008
    },
    "2HoGA5IB": {
        "id": "2HoGA5IB",
        "title": "Analysis of the dynamical behavior for enzyme-catalyzed reactions with impulsive input",
        "abstract": "Previous work has concentrated on the nature and validity of this reactions. In the paper, the dynamical behavior of Michaelis\u2013Menten\n type kinetics for enzyme-catalyzed biochemical reactions is studied. Under the practical background, we investigate the effects\n of impulsive substrate-input.\n ",
        "keywords": [
            "enzymatic-reactions",
            "impulsive input",
            "dissipation",
            "34A37"
        ],
        "authors": [
            {
                "name": "Mingjing Sun",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116024 Peoples Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116024 Peoples Republic of China"
            }
        ],
        "venue": "Journal of Mathematical Chemistry",
        "year": 2008
    },
    "LychBXZD": {
        "id": "LychBXZD",
        "title": "Bifurcation and chaos in a Tessiet type food chain chemostat with pulsed input and washout",
        "abstract": "In this paper, we introduce and study a model of a Tessiet type food chain chemostat with pulsed input and washout. We investigate the subsystem with substrate and prey and study the stability of the periodic solutions, which are the boundary periodic solutions of the system. The stability analysis of the boundary periodic solution yields an invasion threshold. By use of standard techniques of bifurcation theory, we prove that above this threshold there are periodic oscillations in substrate, prey and predator. Simple cycles may give way to chaos in a cascade of period-doubling bifurcations. Furthermore, by comparing bifurcation diagrams with different bifurcation parameters, we can see that the impulsive system shows two kinds of bifurcations, whose are period doubling and period halving.",
        "keywords": [
            "bifurcation theory",
            "bifurcation diagram",
            "food chain",
            "stability analysis",
            "oscillations"
        ],
        "authors": [
            {
                "name": "Fengyan Wang",
                "org": ""
            },
            {
                "name": "Chunping Hao",
                "org": "College of Science, Jimei University, Xiamen, Fujian 361021, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2007
    },
    "SP9zFf8g": {
        "id": "SP9zFf8g",
        "title": "A piecewise smooth rangeland grazing model shows that setting recovery period of plant is beneficial to prevent overgrazing",
        "abstract": "Recently, people pay more attention to overgrazing due to its extensive damaging effects on ecological systems. How to solve the remarkable problem is essentially an important topic. In this paper, setting the recovery period of plant population, we simulate the dynamics of rangeland grazing pattern with a mathematical model. Using the corresponding difference system determined by the model, we obtain the critical value of recovery period which is a ratio of the birth rate of grazer population during the grazing period to the sum of it and the death rate of grazer population during the recovery period. If the recovery period is above the critical value, the grazer population will become extinct; if the recovery period is below the critical value, we obtain the explicit expression of the positive periodic solution which is globally stable, i.e. two kinds of population are all persistent. Further, we find the maximum of grazer population's density when the density of grass population is not below a threshold. Our research demonstrates that properly timed grazing plays a key role in protecting grassland environment, or say, the recovery period of plant population is below the critical value; managed grazing is arguably the only natural process by which grassland can be improved on a sustainable basis. Controlled grazing can regenerate grassland, preserve healthy soil and improve livestock production simultaneously. Our results are valuable for rangeland grazing management in practice. \u00a9 World Scientific Publishing Company.",
        "keywords": [
            "overgrazing",
            "rangeland grazing model",
            "recovery period"
        ],
        "authors": [
            {
                "name": "Jing Hui",
                "org": "Guangxi University of Technology(Guangxi University of Technology ^),Liuzhou,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            }
        ],
        "venue": "Journal of Biological Systems",
        "year": 2006
    },
    "gOggBlGv": {
        "id": "gOggBlGv",
        "title": "The dynamics of a prey-dependent consumption model concerning impulsive control strategy",
        "abstract": "A mathematical model for dynamics of a prey-dependent consumption model concerning impulsive control strategy is proposed and analyzed. We show that there exists a globally stable pest-eradication periodic solution when the impulsive period is less than some critical values. Further, the conditions for the permanence of system are given. We show the existence of nontrivial periodic solution if the pest-eradication periodic solution loses its stability. When the unique positive periodic solution lose its stability, numerical simulation shows there is a characteristic sequence of bifurcations, leading to a chaotic dynamics, which implies that the impulsive control model we considered has more complex dynamics including period-doubling bifurcation, symmetry-breaking bifurcation, period-halving bifurcation, quasi-periodic oscillation and chaos.",
        "keywords": [
            "permanence",
            "mathematical model",
            "impulsive control model",
            "prey-dependent consumption model",
            "impulsive effect",
            "pest-eradication periodic solution",
            "stable pest-eradication periodic solution",
            "period-doubling bifurcation",
            "nontrivial periodic solution",
            "impulsive control strategy",
            "chaos",
            "period-halving bifurcation",
            "impulsive period",
            "unique positive periodic solution",
            "biological and chemical control",
            "numerical simulation",
            "critical value",
            "complex dynamics",
            "symmetry breaking"
        ],
        "authors": [
            {
                "name": "Bing Liu",
                "org": "Department of Mathematics, Xinjiang University, Urumqi, Xinjiang 830046, PR China and Department of Mathematics, Anshan Normal University, Anshan, Liaoning 114005, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Beijing 100080, PR China"
            },
            {
                "name": "Yujuan Zhang",
                "org": "Department of Mathematics, Anshan Normal University, Anshan, Liaoning 114005, PR China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2005
    },
    "4cPwlHeA": {
        "id": "4cPwlHeA",
        "title": "Dynamics of a plankton-nutrient chemostat model with hibernation and it described by impulsive switched systems",
        "abstract": "In this paper, we consider a hibernation plankton-nutrient chemostat model with impulsive switched systems describing. Employing the discrete dynamical system determined by the stroboscopic map, we obtain a plankton-extinction periodic solution. Further, it is globally asymptotically stable. The permanent condition of the system (2.1) is also obtained by the theory on impulsive differential equation. Our results reveal that the impulsive diffusion amount plays an important role on the chemostat system.",
        "keywords": [
            "Chemostat model",
            " Hibernation",
            " Impulsive diffusion",
            " Extinction",
            " Permanence",
            " 34A37",
            " 92B05"
        ],
        "authors": [
            {
                "name": "jianjun jiao",
                "org": "School of Mathematics and Statistics, Guizhou Key Laboratory of Economic System Simulation,Guizhou College of Finance and Economics,Guiyang,People\u2019s Republic of China"
            },
            {
                "name": "shaohong cai",
                "org": "School of Mathematics and Statistics, Guizhou Key Laboratory of Economic System Simulation,Guizhou College of Finance and Economics,Guiyang,People\u2019s Republic of China"
            },
            {
                "name": "lansun chen",
                "org": "Institute of Mathematics,Academy of Mathematics and System Sciences,Beijing,People\u2019s Republic of China"
            }
        ],
        "venue": "Journal of Applied Mathematics and Computing",
        "year": 2016
    },
    "LxUGT8ot": {
        "id": "LxUGT8ot",
        "title": "Permanence and the Existence of the Periodic Solution of the Non-Autonomous Two-Species Competitive Model with Stage Structure",
        "abstract": "",
        "keywords": [
            "asymptotic stability",
            "existence of periodic solution",
            "permanence",
            "stage structure"
        ],
        "authors": [
            {
                "name": "Guangzhao Zeng",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            },
            {
                "name": "Lihua Sun",
                "org": ""
            },
            {
                "name": "Ying Liu",
                "org": ""
            }
        ],
        "venue": "Advances in Complex Systems",
        "year": 2004
    },
    "26uXl6MP": {
        "id": "26uXl6MP",
        "title": "Existence and global stability of periodic solution for impulsive predator-prey model with diffusion and distributed delay",
        "abstract": "In this paper, the nonlinear nonautonomous predator-prey model with impulsive effect is considered. By using the method of coincidence degree theorem, a set of easily verifiable sufficient conditions are obtained for the existence of at least one strictly positive periodic solution, and by the means of a suitable Lyapunov function, the uniqueness and global attractivity of positive periodic solution are presented. An example shows the feasibility of our main results. \u00a9 2009 Korean Society for Computational and Applied Mathematics.",
        "keywords": [
            "diffusion",
            "global attractivity",
            "impulse",
            "periodic solution",
            "lyapunov function"
        ],
        "authors": [
            {
                "name": "Zhong Zhao",
                "org": "Huanghuai University(Huanghuai University),Zhumadian,China"
            },
            {
                "name": "Zuxiong Li",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            }
        ],
        "venue": "Journal of Applied Mathematics and Computing",
        "year": 2010
    },
    "9M0kmAi9": {
        "id": "9M0kmAi9",
        "title": "Dynamic complexities of a food chain model with impulsive perturbations and Beddington\u2013DeAngelis functional response",
        "abstract": "In this paper, the dynamic complexities of a three trophic level food chain system with impulsive perturbations and Beddington\u2013DeAngelis functional responses is studied. Conditions for extinction of predator are given. By using the Floquet theory of impulsive equation and small amplitude perturbation skills, we consider the local stability of predator eradication periodic solution. Further, influences of the impulsive perturbation on the inherent oscillation are studied numerically, which shows the rich dynamics in the positive octant.",
        "keywords": [
            "oscillations",
            "food chain",
            "floquet theory",
            "functional response",
            "trophic level"
        ],
        "authors": [
            {
                "name": "Shuwen Zhang",
                "org": ""
            },
            {
                "name": "Dejun Tan",
                "org": "Editorial department of journal, Anshan Normal University, Anshan, Liaoning 114005, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian, Liaoning 116024, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2006
    },
    "WFGQk666": {
        "id": "WFGQk666",
        "title": "The periodic competing Lotka-Volterra model with impulsive effect.",
        "abstract": "In this paper, the dynamic behaviour of a classical periodic Lotka-Volterra competing system with impulsive effect is investigated. By applying the Floquet theory of linear periodic impulsive equations, some conditions are obtained for the linear stability of the trivial and semi-trivial periodic solutions. It is proved that the system can be permanent if all the trivial and semi-trivial periodic solutions are linearly unstable. We use standard bifurcation theory to show the existence of nontrivial periodic solutions which arise near the semi-trivial periodic solution. As an application, a fish harvest problem is considered. We explain how two competing species, one of which in a periodic environment without impulsive effect would be doomed to extinction, can coexist with suitably periodic impulsive harvesting.",
        "keywords": [
            "bifurcation",
            "extinction",
            "coexistence",
            "competing system",
            "impulsive effect"
        ],
        "authors": [
            {
                "name": "Bing Liu",
                "org": "Department of Mathematics, Anshan Normal University, Anshan, Liaoning 114005, People's Republic of China. liubing@amss.ac.cn"
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Mathematical medicine and biology : a journal of the IMA",
        "year": 2004
    },
    "6e0C2NyA": {
        "id": "6e0C2NyA",
        "title": "Pulse vaccination of an SEIR epidemic model with time delay",
        "abstract": "Pulse vaccination is an effective strategy for the elimination of infectious diseases. A delayed epidemic model with pulse vaccination is formulated in this paper. It is proved that the disease-free periodic solution is globally attractive if the vaccination rate is larger than \u03b8 * , and the disease is uniformly persistent if the vaccination rate is less than \u03b8 * . The permanence of the model is investigated analytically. Our results indicate that large vaccination rate or short pulse of vaccination or long latent period is sufficient condition for the extinction of the disease.",
        "keywords": [
            "global attractivity",
            "seir epidemic model",
            "permanence",
            "pulse vaccination",
            "delay",
            "epidemic model",
            "infectious disease"
        ],
        "authors": [
            {
                "name": "Shujing Gao",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            },
            {
                "name": "Zhidong Teng",
                "org": "College of Mathematics and Systems Science, Xinjiang University, Urumqi 830046, PR China"
            }
        ],
        "venue": "Nonlinear Analysis: Real World Applications",
        "year": 2008
    },
    "cxMsVsb5": {
        "id": "cxMsVsb5",
        "title": "Global Stability for a Generalized Predator\ufffdPrey System with Time Delay In Two-patch Environments",
        "abstract": "",
        "keywords": [
            "lyapunov function"
        ],
        "authors": [
            {
                "name": "robert p gilbert",
                "org": ""
            },
            {
                "name": "rui xu",
                "org": ""
            },
            {
                "name": "lansun chen",
                "org": ""
            }
        ],
        "venue": "Applicable Analysis",
        "year": 2003
    },
    "4SaasssX": {
        "id": "4SaasssX",
        "title": "Globally asymptotic stability in two periodic delayed competitive systems",
        "abstract": "Based on two types of well known periodic single-species population growth models with time delay, we propose two corresponding periodic competitive systems with multiple delays. By using some new analysis techniques, we derive the same criteria for the existence and globally asymptotic stability of positive periodic solutions of the above two competitive systems. The easily verifiable criteria show that the existence and globally asymptotic stability of positive periodic solutions of two delayed nonautonomous competitive systems correspond to the existence and global stability of positive equilibrium of corresponding undelayed autonomous system. As an application, some special cases of the above systems are examined and some earlier results are extended and improved. Biological interpretations on the main results are also given.",
        "keywords": [
            "lyapunov functional",
            "continuation theorem",
            "globally asymptotic stability",
            "delayed competitive system",
            "periodic solution",
            "lyapunov function",
            "population growth"
        ],
        "authors": [
            {
                "name": "Zhijun Liu",
                "org": ""
            },
            {
                "name": "Meng Fan",
                "org": "School of Mathematics and Statistics, Northeast Normal University, Changchun, 130024 Jilin, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian, 116024 Liaoning, PR China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2008
    },
    "3ZEzUbKv": {
        "id": "3ZEzUbKv",
        "title": "Mathematical models of restoration and control of a single species with Allee effect",
        "abstract": "According to the initial density of a single species with Allee effect and corresponding management strategy, three kinds of mathematical models are presented to describe the evolutionary process of the species by impulsive differential equations. When the initial density of the species is larger than economic injury level (EIL) (or economical threshold, ET), impulsive harvest control is considered in a finite time to decrease the population of the species. The feasibility of the impulsive harvest control in a finite time is given by the existence of solution of the model with initial and boundary value problem. When the initial density of the species is less than EIL (or ET), the model with state feedback control is formulated according to the state of the species. The existence and stability of periodic solution of the model with state feedback control are discussed. When the initial density of the species is less than the Allee threshold and the species tends to extinction, the model with impulsive release at fixed moments is presented to study the restoration of the species. The conditions for the feasibility of periodic restoration of the species are given. Finally, some discussions are given.",
        "keywords": [
            "Allee effect",
            "Impulsive differential equation",
            "Impulsive effect",
            "Boundary value problem",
            "Single species"
        ],
        "authors": [
            {
                "name": "Hongjian Guo",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, PR China"
            },
            {
                "name": "Xinyu Song",
                "org": "Department of Mathematics and Information Science, Xinyang Normal University, Xinyang 464000, PR China"
            }
        ],
        "venue": "Applied Mathematical Modelling",
        "year": 2010
    },
    "MQNsP8qS": {
        "id": "MQNsP8qS",
        "title": "A Stage-Structured Predator-Prey Model with Time Delays",
        "abstract": "A delayed predator-prey model with stage structure for prey is investigated. By constructing suitable Lyapunov functionals, the authors discuss the global attractivity of nonnegative equilibria. A set of easily verifiable sufficient conditions are derived for the permanence and extinction of the proposed ecological system.",
        "keywords": [
            "Permanence",
            "Time delay",
            "Stage structure",
            "Predator-prey model",
            "Extinction."
        ],
        "authors": [
            {
                "name": "Xu Rui",
                "org": "Institute of Mathematics, Chinese Academy of Sciences, Beijing "
            },
            {
                "name": "Hao Feilong",
                "org": "Institute of Mathematics, Chinese Academy of Sciences, Beijing "
            },
            {
                "name": "Chen Lansun",
                "org": "Institute of Mathematics, Chinese Academy of Sciences, Beijing "
            }
        ],
        "venue": "Acta Mathematica Scientia",
        "year": 2006
    },
    "cQj7PZC8": {
        "id": "cQj7PZC8",
        "title": "Extinction and permanence of a two-prey one-predator system with impulsive effect.",
        "abstract": "In this paper, we investigate a two-prey one-predator system with impulsive effect on the predator of fixed moment. By using Floquet's theorem and small-amplitude perturbation skills, we show that there exists a globally asymptotically stable two-pest eradication periodic solution when the impulsive period is less than some critical value. Further, we prove that the system is permanent if the impulsive period is larger than some critical value, and meanwhile the conditions for the extinction of one of the two prey and permanence of the remaining two species are given. Finally, numerical simulation shows that there exists a stable positive periodic solution with a maximum value no larger than a given level. Therefore, we can use the stability of the positive periodic solution and its period to control insect pests at acceptably low levels.",
        "keywords": [
            "extinction",
            "impulsive effect",
            "permanence",
            "two-prey one-predator system"
        ],
        "authors": [
            {
                "name": "Yujuan Zhang",
                "org": "Applied Mathematics, Dalian University of Technology, Dalian, Liaoning 116024, Peoples' Republic of China. zhangyujuan1968@163.com"
            },
            {
                "name": "Bing Liu",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Mathematical medicine and biology : a journal of the IMA",
        "year": 2003
    },
    "a8r2BNnb": {
        "id": "a8r2BNnb",
        "title": "Qualitative analysis of a korean pine forest model with impulsive thinning measure",
        "abstract": "A korean pine forest model with impulsive thinning measure is presented by using impulsive state feedback system to investigate the periodicity of the regeneration process of the forest. Based on the qualitative properties of the corresponding continuous system, the existences of order-1 periodic solutions are discussed. If the positive equilibrium of the continuous system is globally stable, then the impulsive state feedback system has an order-1 periodic solution and no order- k ( k \u00bf 2 ) periodic solution. The conditions for the orbitally asymptotical stability of order-1 periodic solution are given and discussed by the analogue of the Poincar\u00e9 criterion. For the case that the continuous system has a stable limit cycle, the existence of order-1 periodic solution of the impulsive state feedback system are also discussed, the results show that there are three kinds of order-1 periodic solutions. Finally, the mathematical results are verified by the numerical simulations. Moreover, the numerical results show that the impulsive state feedback system has order k ( k \u00bf 1 ) periodic solutions in the interior of the limit cycle of the continuous system for some parameters.",
        "keywords": [
            "impulsive state feedback system",
            "korean pine forest model",
            "order-k (k \ufffd\ufffd 1) periodic solutions"
        ],
        "authors": [
            {
                "name": "Hongjian Guo",
                "org": ""
            },
            {
                "name": "Xinyu Song",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2014
    },
    "xouqMrDI": {
        "id": "xouqMrDI",
        "title": "Effect of delayed response in growth on the dynamics of a chemostat model with impulsive input",
        "abstract": "In this paper, a chemostat model with delayed response in growth and impulsive perturbations on the substrate is considered. Using the discrete dynamical system determined by the stroboscopic map, we obtain a microorganism-extinction periodic solution, further, the globally attractive condition of the microorganism-extinction periodic solution is obtained. By the use of the theory on delay functional and impulsive differential equation, we also obtain the permanent condition of the investigated system. Our results indicate that the discrete time delay has influence to the dynamics behaviors of the investigated system, and provide tactical basis for the experimenters to control the outcome of the chemostat. Furthermore, numerical analysis is inserted to illuminate the dynamics of the system affected by the discrete time delay.",
        "keywords": [
            "numerical analysis",
            "discrete time"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": ""
            },
            {
                "name": "Xiaosong Yang",
                "org": "School of Mathematics and Statistics, Huazhong University of Science and Technology, Wuhan 430074, People\u2019s Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academia Sinica, Beijing 100080, People\u2019s Republic of China"
            },
            {
                "name": "Shaohong Cai",
                "org": "Guizhou Key Laboratory of Economics System Simulation, Guizhou College of Finance & Economics, Guiyang 550004, People\u2019s Republic of China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2009
    },
    "SURHqZSR": {
        "id": "SURHqZSR",
        "title": "Bifurcation and chaos in a Monod\u2013Haldene type food chain chemostat with pulsed input and washout",
        "abstract": "In this paper, we introduce and study a model of a Monod\u2013Haldene type food chain chemostat with pulsed input and washout. We investigate the subsystem with substrate and prey and study the stability of the periodic solutions, which are the boundary periodic solutions of the system. The stability analysis of the boundary periodic solution yields an invasion threshold. By use of standard techniques of bifurcation theory, we prove that above this threshold there are periodic oscillations in substrate, prey and predator. Simple cycles may give way to chaos in a cascade of period-doubling bifurcations. Furthermore, by comparing bifurcation diagrams with different bifurcation parameters, we can see that the impulsive system shows two kinds of bifurcations, whose are period-doubling and period-halving.",
        "keywords": [
            "food chain",
            "stability analysis",
            "bifurcation diagram",
            "bifurcation theory",
            "oscillations"
        ],
        "authors": [
            {
                "name": "Fengyan Wang",
                "org": ""
            },
            {
                "name": "Chunping Hao",
                "org": "Department of Information and Computer Science, The Second Northwest University for Minorities, Yinchuan Ningxia 750021, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2007
    },
    "wqMbNkuM": {
        "id": "wqMbNkuM",
        "title": "Time-limited pest control of a Lotka\u2013Volterra model with impulsive harvest",
        "abstract": "A kind of time-limited pest control of a Lotka\u2013Volterra model with impulsive harvest, described by the initial and boundary value problem of impulsive differential equation, is presented. The aim of pest control can be achieved if the model has a solution, otherwise the aim cannot be achieved. By the comparison principle, the conditions under which the model has a solution are found by a series of the upper solutions and the conditions under which the model has no solution are also given by a series of the lower solutions. Furthermore, if the other parameters are given, the times of harvesting pest in the given time is estimated. The theoretical results and the numerical simulations show that the density of the natural enemy will decrease when the pest decreases although the control measures to the pest do not directly affect the natural enemy. Finally, some discussions are given.",
        "keywords": [
            "impulsive differential equation",
            "upper and lower solution",
            "lotka\u2013volterra predator\u2013prey model",
            "comparison principle",
            "boundary value problem",
            "impulsive control",
            "numerical simulation",
            "pest control"
        ],
        "authors": [
            {
                "name": "Hongjian Guo",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, PR China"
            }
        ],
        "venue": "Nonlinear Analysis: Real World Applications",
        "year": 2009
    },
    "yp68mGMv": {
        "id": "yp68mGMv",
        "title": "Periodic Solutions of a Discrete Time nonautonomous Two-Species mutualistic System with Delays",
        "abstract": "",
        "keywords": [
            "coincidence degree",
            "discrete mutualisitic system",
            "positive periodic solution",
            "discrete time"
        ],
        "authors": [
            {
                "name": "Zhijun Liu",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Advances in Complex Systems",
        "year": 2006
    },
    "CXuCEIkQ": {
        "id": "CXuCEIkQ",
        "title": "Effects of diffusion on a stage-structured population in a polluted environment",
        "abstract": "A stage-structured model of population with diffusion in a polluted patch environment is proposed. The mature individuals can diffuse between two patches, and the effects of diffusion on population growth in a polluted patch environment are studied. Some sufficient conditions on permanence and extinction of population are obtained. It is also proved that the number of population changes periodically under some conditions.",
        "keywords": [
            "pollution",
            "diffusion",
            "extinction",
            "permanence",
            "stage-structure",
            "patch environment",
            "population change",
            "population growth"
        ],
        "authors": [
            {
                "name": "Lixia Duan",
                "org": "School of Science, Beijing University of Aeronautics and Astronautics, 100083 Beijing, PR China"
            },
            {
                "name": "Qishao Lu",
                "org": ""
            },
            {
                "name": "Zaizhong Yang",
                "org": "Department of Mathematics, Inner Mongolia University, 010021 Hohhot, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Chinese Academy of Sciences, 100080 Beijing, PR China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2004
    },
    "KCmMQk76": {
        "id": "KCmMQk76",
        "title": "Dynamic analysis of lactic acid fermentation in membrane bioreactor.",
        "abstract": "In this paper, a mathematical model for the lactic acid fermentation in membrane bioreactor is investigated. This novel theoretical framework could result in an objective criterion on how to control the substrate concentration in order to keep a sustainable and steady output of lactic acid. Firstly, continuous input substrate is taken. The existence and local stability of two equilibria are studied. According to Poincar\u00e9-Bendixson Theorem, we obtain the conditions for the globally asymptotical stability of the equilibrium. Secondly, impulsive input substrate is also considered. Using Floquet's theorem and small-amplitude perturbation, we obtain the biomass-free periodic solution is locally stable if some conditions are satisfied. In a certain limiting case, it is shown that a nontrivial periodic solution emerges via a supercritical bifurcation. Finally, our findings are confirmed by means of numerical simulations.",
        "keywords": [
            "bifurcation",
            "globally asymptotically stable",
            "periodic solution",
            "qualitative analysis"
        ],
        "authors": [
            {
                "name": "Zhong Zhao",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Journal of theoretical biology",
        "year": 2009
    },
    "oNeu7fwy": {
        "id": "oNeu7fwy",
        "title": "State-feedback Controls of Water Hyacinth Eco-system",
        "abstract": "This paper discusses certain eco-system of water hyacinth with collectively defense based on Logistic growth.First,we gain a qualitative conclusion of systems without impulsive function.Further,for systems with state-feedback controls impulse,by using successor function of differential equation geometry theory,the sufficient conditions for the existence and orbitally asymptotic stability of an order one periodic solution are obtained.Finally,applying numerical analog,we discuss the ecological significance of the system.",
        "keywords": [
            "Existence",
            "Impulse control",
            "State-feedback",
            "Order one periodic solution",
            "Stability"
        ],
        "authors": [
            {
                "name": "FU Jinbo",
                "org": "Minnan Science and Technology Institute,Fujian Normal University,Quanzhou ,China"
            },
            {
                "name": "CHEN Lansun",
                "org": "Minnan Science and Technology Institute,Fujian Normal University,Quanzhou ,China;Academy of Mathematics and Systems Science,Chinese Academy of Sciences,Beijing ,China"
            }
        ],
        "venue": "Mathematica Applicata",
        "year": 2013
    },
    "T2NjcUVT": {
        "id": "T2NjcUVT",
        "title": "The effects of habitat fragmentation and ecological invasion on population sizes",
        "abstract": "In this paper, we consider the effects of habitat fragmentation and ecological invasion of exotic species on the survival of a native endangered species, respectively. Different from the former studies, we pay attention on the more important situation in conservation biology that species live in a weak patchy environment in the sense that species in some of the isolated patches will become extinct without the contribution from other patches. We establish some foundmental permanence and extinction results on the basic and important nonautonomous diffusive Logistic model. In addition, by using these results, we consider the effect of an introduced species on the survival of a native species through competition. Biological implications of these results are discussed.",
        "keywords": [
            "permanence",
            "extinction",
            "diffusion",
            "ecological invasion",
            "habitat fragmentation",
            "native species",
            "exotic species",
            "introduced species",
            "logistic model",
            "population size",
            "endangered species",
            "conservation biology"
        ],
        "authors": [
            {
                "name": "Jingan Cui",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Computers and Mathematics with Applications",
        "year": 1999
    },
    "P1sKOXJV": {
        "id": "P1sKOXJV",
        "title": "Study of a Monod\u2013Haldene type food chain chemostat with pulsed substrate",
        "abstract": "In this paper, we introduce and study a model of a Monod\u2013Haldene type food chain chemostat with pulsed substrate. We investigate\n the subsystem with substrate and prey and study the stability of the periodic solutions, which are the boundary periodic solutions\n of the system. The stability analysis of the boundary periodic solution yields an invasion threshold. By use of standard techniques\n of bifurcation theory, we prove that above this threshold there are periodic oscillations in substrate, prey, and predator.\n Simple cycles may give way to chaos in a cascade of period-doubling bifurcations. Furthermore, by comparing bifurcation diagrams\n with different bifurcation parameters, we can see that the impulsive system shows two kinds of bifurcations, whose are period-doubling\n and period-halfing.\n ",
        "keywords": [
            "bifurcation",
            "Monod-Haldene growth rates",
            "chemostat",
            "invasion",
            "complexity"
        ],
        "authors": [
            {
                "name": "Fengyan Wang",
                "org": "North University for Minorities Department of Information and Computer Science Yinchuan Ningxia 750021 People\u2019s Republic of China"
            },
            {
                "name": "Guoping Pang",
                "org": "Yulin Normal University Department of Mathematics and Computer Science Yulin Guangxi 537000 People\u2019s Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116024 People\u2019s Republic of China"
            }
        ],
        "venue": "Journal of Mathematical Chemistry",
        "year": 2008
    },
    "lwVtasr1": {
        "id": "lwVtasr1",
        "title": "Analysis of an SEIRS Epidemic Model with Time Delays And Pulse Vaccination",
        "abstract": "",
        "keywords": [
            "global attractivity",
            "permanence",
            "pulse vaccination",
            "seirs epidemic model",
            "time delay",
            "epidemic model"
        ],
        "authors": [
            {
                "name": "Shujing Gao",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            },
            {
                "name": "Zhidong Teng",
                "org": ""
            }
        ],
        "venue": "Rocky Mountain Journal of Mathematics",
        "year": 2008
    },
    "5TYhHL9x": {
        "id": "5TYhHL9x",
        "title": "Two profitless delays for an SEIRS epidemic disease model with vertical transmission and pulse vaccination",
        "abstract": "Since the investigation of impulsive delay differential equations is beginning, the literature on delay epidemic models with pulse vaccination is not extensive. In this paper, we propose a new SEIRS epidemic disease model with two profitless delays and vertical transmission, and analyze the dynamics behaviors of the model under pulse vaccination. Using the discrete dynamical system determined by the stroboscopic map, we obtain a \u2018infection-free\u2019 periodic solution, further, show that the \u2018infection-free\u2019 periodic solution is globally attractive when some parameters of the model are under appropriate conditions. Using a new modeling method, we obtain sufficient condition for the permanence of the epidemic model with pulse vaccination. We show that time delays, pulse vaccination and vertical transmission can bring different effects on the dynamics behaviors of the model by numerical analysis. Our results also show the delays are \u201cprofitless\u201d. In this paper, the main feature is to introduce two discrete time delays, vertical transmission and impulse into SEIRS epidemic model and to give pulse vaccination strategies.",
        "keywords": [
            "epidemic model",
            "discrete time",
            "delay differential equation",
            "numerical analysis"
        ],
        "authors": [
            {
                "name": "Xinzhu Meng",
                "org": ""
            },
            {
                "name": "Jianjun Jiao",
                "org": "School of Mathematics and Statistics, Guizhou College of Finance and Economics, Guiyang 550004, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2009
    },
    "FufdG6TU": {
        "id": "FufdG6TU",
        "title": "Dynamic complexities in a single-species discrete population model with stage structure and birth pulses",
        "abstract": "Natural population, whose population numbers are small and generations are non-overlapping, can be modelled by difference equations that describe how the population evolve in discrete time-steps. This paper investigates a recent study on the dynamics complexities in a single-species discrete population model with stage structure and birth pulses. Using the stroboscopic map, we obtain an exact cycle of system, and obtain the threshold conditions for its stability. Above this, there is a characteristic sequence of bifurcations, leading to chaotic dynamics, which implies that this the dynamical behaviors of the single-species discrete model with birth pulses are very complex, including (a) non-unique dynamics, meaning that several attractors and chaos coexist; (b) small-amplitude annual oscillations; (c) large-amplitude multi-annual cycles; (d) chaos. Some interesting results are obtained and they showed that pulsing provides a natural period or cyclicity that allows for a period-doubling route to chaos.",
        "keywords": [
            "oscillations",
            "discrete time",
            "difference equation",
            "annual cycle",
            "natural population",
            "population model"
        ],
        "authors": [
            {
                "name": "Shujing Gao",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2005
    },
    "IIenYVbq": {
        "id": "IIenYVbq",
        "title": "Quasiperiodic Solutions and Chaos in a Periodically Forced Predator-prey Model with Age Structure for predator",
        "abstract": "",
        "keywords": [
            "Age-structure",
            "Chaos",
            "Predator-prey model",
            "Quasiperiodic solutions"
        ],
        "authors": [
            {
                "name": "Sanyi Tang",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "I. J. Bifurcation and Chaos",
        "year": 2003
    },
    "nWoaeO8O": {
        "id": "nWoaeO8O",
        "title": "Global attractivity in a \u201cfood-limited\u201d population model with impulsive effects",
        "abstract": "Sufficient conditions are obtained for the global attractivity of the positive equilibrium of the delay-logistic equation with impulsive effect N \u0307 (t)=r(t)N(t) K\u2212N p (t\u2212\u03c4) K+c(t)N p (t\u2212\u03c4) , N(\u03c4 k + )=N(\u03c4 k ) exp I k ln N(\u03c4 k ) K p , where r ( t ), c ( t ) are continuous functions, p , K , \u03c4 are positive constants, and { \u03c4 k } k =1 \u221e denotes the sequence of impulsive time which assumed to be strictly increasing. Some special cases are also considered. References [1] E.C. Pielou An Introduction to Mathematical Ecology 1969 Wiley New York [2] K. Gopalsamy M.R.S. Kulenovic G. Ladas Environment periodicity and time delays in a \u201cfood-limited\u201d population model J. Math. Anal. Appl. 147 1990 545 555 [3] K. Gopalsamy M.R.S. Kulenovic G. Ladas Time lags in a food-limited populated model Appl. Anal. 31 1988 225 237 [4] E.A. Grove G. Ladas C. Qian Global attractivity in a food-limited population model Dynam. Systems Appl. 2 1993 243 250 [5] Y. Kuang Delay Differential Equations with Applications in Population Dynamics 1993 Academic Press Boston [6] K. Gopalsamy Stability and Oscillations in Delay Differential Equations of Population Dynamics 1992 Kluwer Academic Dordrecht [7] D.D. Bainov P.S. Simeonov Systems with Impulse Effect, Theory and Applications Ellis Horwood Series in Mathematics and Its Applications 1989 Ellis Horwood Chichester [8] V. Lakshmikantham D.D. Bainov P.S. Simeonov Theory of Impulsive Differential Equations World Scientific Series in Modern Mathematics vol. 6 1989 World Scientific Singapore [9] K. Gopalsamy B.G. Zhang On the delay differential equations with impulses J. Math. Anal. Appl. 139 1989 110 122 [10] Y.J. Dong Periodic boundary value problems for functional differential equations with impulses J. Math. Anal. Appl. 210 1997 170 181 [11] J.R. Yan A.M. Zhao Oscillation and stability of linear impulsive delay differential equations J. Math. Anal. Appl. 227 1998 187 194 [12] D.D. Bainov Oscillatory solution of a class of nonlinear impulsive differential equation of first order retarded argument J. Appl. Anal. 4 1998 215 230",
        "keywords": [
            "population model",
            "logistic equation"
        ],
        "authors": [
            {
                "name": "Sanyi Tang",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences Chinese Academy of Sciences, Beijing 100080, PR China"
            }
        ],
        "venue": "Journal of Mathematical Analysis and Applications",
        "year": 2004
    },
    "YzZqH56k": {
        "id": "YzZqH56k",
        "title": "A Class of Cubic Systems with Two Centers or Two Foci",
        "abstract": "In this paper, the necessary and sufficient conditions for a class of cubic differential systems to possess two centers are given. Some conditions for the systems to have two weak foci are also derived by using the computer algebra system Maple.",
        "keywords": [
            "center",
            "focus",
            "kukles system"
        ],
        "authors": [
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academia Sinica, Beijing, 100080, China"
            },
            {
                "name": "Zhengyi Lu",
                "org": "Department of Mathematics, Sichuan University, Chengdu, 610064, China"
            },
            {
                "name": "Dongming Wang",
                "org": "Laboratoire LEIBNIZ, Institut IMAG, 46, avenue F\u00e9lix Viallet, 38031, Grenoble, France"
            }
        ],
        "venue": "Journal of Mathematical Analysis and Applications",
        "year": 2000
    },
    "KozErPth": {
        "id": "KozErPth",
        "title": "Harvesting on a stage-structured single population model with mature individuals in a polluted environment and pulse input of environmental toxin.",
        "abstract": "In the natural world, there are many species whose individual members have a life history that they take them with two distinct stages: immaturity and maturity. In particular, we have in mind mammalian populations and some amphibious animals. We improve the assumption of a single population as a whole. It is assumed that the immature individuals and mature individuals are divided by a fixed period. This paper concentrates on the study of a stage-structured single population model with mature individuals in a polluted environment and pulse input of environmental toxin at fixed moments. Furthermore, the mature individuals are harvested continuously. We show that the population goes extinct if the harvesting rate is beyond a critical threshold. Conditions for the extended permanence of the population are also examined. From the biological point of view, it is easy to protect species by controlling the harvesting amount, impulsive period of the exogenous input of toxin and toxin impulsive input amount, etc. Our results provide reasonable tactics for biological resource management.",
        "keywords": [
            "global attractivity",
            "permanence",
            "stage-structured",
            "single population",
            "resource manager",
            "life history",
            "population model"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": ""
            },
            {
                "name": "Xiaosong Yang",
                "org": "School of Mathematics and Statistics, Guizhou Key Laboratory of Economics System Simulation, Guizhou College of Finance and Economics, Guiyang 550004, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academia Sinica, Beijing 100080, PR China"
            }
        ],
        "venue": "BioSystems",
        "year": 2009
    },
    "D9EEFiT9": {
        "id": "D9EEFiT9",
        "title": "Permanence and global attractivity of stage-structured predator-prey model with continuous harvesting on predator and impulsive stocking on prey",
        "abstract": "We investigate a stage-structured delayed predator-prey model with impulsive stocking on prey and continuous harvesting on\n predator. According to the fact of biological resource management, we improve the assumption of a predator-prey model with\n stage structure for predator population that each individual predator has the same ability to capture prey. It is assumed\n that the immature and mature individuals of the predator population are divided by a fixed age, and immature predator population\n does not have the ability to attach prey. Sufficient conditions are obtained, which guarantee the global attractivity of predator-extinction\n periodic solution and the permanence of the system. Our results show that the behavior of impulsive stocking on prey plays\n an important role for the permanence of the system, and provide tactical basis for the biological resource management. Numerical\n analysis is presented to illuminate the dynamics of the system.",
        "keywords": [
            "impulsive stocking",
            "permanence chinese library classification o175 2000 mathematics subject classification 34a37",
            "continuous harvesting",
            "permanence",
            "92b05",
            "global attrac- tivity",
            "stage-structured",
            "global attractivity"
        ],
        "authors": [
            {
                "name": "Jian-jun Jiao",
                "org": "Guizhou College of Finance and Economics School of Mathematics and Statistics Guiyang 550004 P. R. China"
            },
            {
                "name": "Lan-sun Chen",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116024 P. R. China"
            },
            {
                "name": "Juan J. Nieto",
                "org": "University of Santiago de Compostela Department of Mathematical Analysis, Faculty of Mathematics 15782 Santiago de Compostela Spain"
            },
            {
                "name": "Torres Angela",
                "org": "Radiology and Public Health Faculty of Medicine University of Santiago de Compostela Department of Psychiatry Santiago de Compostela Spain"
            }
        ],
        "venue": "Applied Mathematics and Mechanics-english Edition",
        "year": 2008
    },
    "AIVoMTQw": {
        "id": "AIVoMTQw",
        "title": "PERMANENCE AND GLOBAL STABILITY IN AN IMPULSIVE LOTKA\u2013VOLTERRA N-SPECIES COMPETITIVE SYSTEM WITH BOTH DISCRETE DELAYS AND CONTINUOUS DELAYS",
        "abstract": "",
        "keywords": [
            "globally asymptotical stability",
            "impulsive effects",
            "lotkavolterra system",
            "permanence",
            "time delays"
        ],
        "authors": [
            {
                "name": "XINZHU MENG",
                "org": ""
            },
            {
                "name": "LANSUN CHEN",
                "org": ""
            }
        ],
        "venue": "International Journal of Biomathematics",
        "year": 2008
    },
    "Sx8dyydC": {
        "id": "Sx8dyydC",
        "title": "A new stage structured predator\u2013prey Gomportz model with time delay and impulsive perturbations on the prey",
        "abstract": "In this paper, we formulate a robust prey-dependent consumption predator\u2013prey Gomportz model with periodic harvesting (catching or poisoning ) for the prey and stage structure for the predator with constant maturation time delay (through-stage time delay) and perform a systematic mathematical and ecological study. By use of the discrete dynamical system determined by the stroboscopic map, we obtain a \u2018predator-extinction\u2019 periodic solution. Further, we show it is globally attractive when some parameters of the system are under appropriate conditions. By using the theory on delay functional and impulsive differential equation, we obtain sufficient condition with time delay for the permanence of the system. In this paper, the main feature is that we introduce time delay and pulse into the predator\u2013prey (natural enemy\u2013pest) model with stage structure, exhibit a new modeling method which is applied to investigate delay impulsive differential equations, and give some reasonable suggestions for pest management.",
        "keywords": [
            "permanence",
            "maturation time delay",
            "extinction",
            "predator\u2013prey model with age structure",
            "impulsive effect",
            "age structure",
            "pest management"
        ],
        "authors": [
            {
                "name": "Kaiyuan Liu",
                "org": ""
            },
            {
                "name": "Xinzhu Meng",
                "org": "College of Science, Shandong University of Science and Technology, Qingdao 266510, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, PR China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2008
    },
    "8v6l46vB": {
        "id": "8v6l46vB",
        "title": "Chaos in a food chain chemostat with pulsed input and washout",
        "abstract": "A food-chain chemostat with periodically pulsed input and washout is presented and analyzed. We prove that when the period of pulses is equal to some critical value, there exists a transcritical bifurcation. When the period is more than the critical value, the zooplankton-free periodic solution loses stability, and nutrient, phytoplankton and zooplankton coexist on a periodic solution of period T . If the period is further increase, the system undergoes a series of period-doubling bifurcations leading to chaos. Moreover, the system is also characterized by non-unique dynamic. Finally, we give a brief discussion and find that periodically pulsed input and washout destroys the equilibria of the unforced continuous system and initiates chaos.",
        "keywords": [
            "food chain",
            "critical value"
        ],
        "authors": [
            {
                "name": "Yujuan Zhang",
                "org": ""
            },
            {
                "name": "Zhilong Xiu",
                "org": "Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian, Liaoning 116024, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Academia Sinia, Beijing 100080, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2005
    },
    "4MuCM8qj": {
        "id": "4MuCM8qj",
        "title": "A SIR epidemic model with two different vaccination strategies",
        "abstract": "The dynamic behaviors of a kind of SIR epidemic model with two different vaccination strategies and saturation infectious force are researched.With continuous vaccination,the basic reproduction number R0 is given.By Lassalle\u2032s theorem and Poincare-Bendixon\u2032s trichotomy theorem,the conditions of global asymptotic stability of disease-free equilibrium and endemic equilibrium are obtained.Moreover,with pulse vaccination,the basic reproduction number R is given.By using Floquet theory and comparison theorem of impulsive differential equation,the global asymptotic stability of the disease-free periodic solution and the identical permanence of system are researched.Results indicate that the disease will die out when the basic reproduction number is less than one,whereas the disease is persistent and becomes endemic when the basic reproduction number is more than one.",
        "keywords": [
            "Continuous vaccination",
            "Global stability",
            "Identical permanence",
            "Pulse vaccination",
            "Saturation infectious force"
        ],
        "authors": [
            {
                "name": "Yongzhen Pei",
                "org": "Tianjin Polytechnic University(Tianjin Polytechnic University),Tianjin,China"
            },
            {
                "name": "LI Chang-guo",
                "org": "Department of Basic Science,Institute of Military Traffic,Tianjin ,China"
            },
            {
                "name": "JI Xue-hui",
                "org": "School of Science,Tianjin Polytechnic University,Tianjin ,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            }
        ],
        "venue": "Journal of Dalian University of Technology",
        "year": 2009
    },
    "3TVfBbhe": {
        "id": "3TVfBbhe",
        "title": "Effect of rhizosphere dispersal and impulsive input on the growth of wetland plant.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Zhong Zhao",
                "org": ""
            },
            {
                "name": "Qiuying Li",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Mathematics and Computers in Simulation",
        "year": 2018
    },
    "zvdaItGN": {
        "id": "zvdaItGN",
        "title": "Global attracting behavior of non-autonomous stage-structured population dynamical system with diffusion",
        "abstract": "A non-autonomous single species dispersal model is considered, in which individual member of the population has a life history that goes through two stages, immature and mature. By applying the theory of monotone and concave operators to functional differential equations, we establish conditions under which the system admits a positive periodic solution which attracts all other positive solutions. \u00a9 Springer-Verlag 2003.",
        "keywords": [
            "dispersal",
            "global attractivity",
            "nonautonomous",
            "stage structure",
            "periodic solution"
        ],
        "authors": [
            {
                "name": "Zhong-hua Lu",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "Xue-bin Chi",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "Lan-sun Chen",
                "org": "Academy of Mathematics and System Sciences Chinese Academy of Sciences(Chinese Academy of Sciences,Academy of Mathematics and Systems Science),Beijing,China"
            }
        ],
        "venue": "Acta Mathematicae Applicatae Sinica-english Series",
        "year": 2003
    },
    "5wagVjON": {
        "id": "5wagVjON",
        "title": "Analysis of a Monod\u2013Haldene type food chain chemostat with periodically varying substrate",
        "abstract": "In this paper, we introduce and study a model of a Monod\u2013Haldene type food chain chemostat with periodically varying substrate. We investigate the subsystem with substrate and prey and study the stability of the periodic solutions, which are the boundary periodic solutions of the system. The stability analysis of the boundary periodic solution yields an invasion threshold. By use of standard techniques of bifurcation theory, we prove that above this threshold there are periodic oscillations in substrate, prey and predator. Furthermore, we numerically simulate a model with sinusoidal input, by comparing bifurcation diagrams with different bifurcation parameters, we can see that the periodic system shows two kinds of bifurcations, whose are period-doubling and period-halfing.",
        "keywords": [
            "bifurcation diagram",
            "food chain",
            "stability analysis",
            "numerical simulation",
            "bifurcation theory",
            "oscillations"
        ],
        "authors": [
            {
                "name": "Guoping Pang",
                "org": ""
            },
            {
                "name": "Fengyan Wang",
                "org": "College of Science, Jimei University, Xiamen Fujian 361021, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2008
    },
    "pmlvwaWI": {
        "id": "pmlvwaWI",
        "title": "Erratum to: Nonlinear analysis of a microbial pesticide model with impulsive state feedback control",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Tieying Wang",
                "org": "School of Mathematical Sciences, Dalian University of Technology, 116024 Dalian, P.R. China"
            },
            {
                "name": "Lansun Chen",
                "org": "School of Mathematical Sciences, Dalian University of Technology, 116024 Dalian, P.R. China"
            }
        ],
        "venue": "Nonlinear Dynamics",
        "year": 2011
    },
    "sQFMFb6U": {
        "id": "sQFMFb6U",
        "title": "Analysis of SIRS model with saturated contact rate and pulse vaccination",
        "abstract": "In order to constitute the reasonable immune vaccination strategy and prevent the infectious diseases from arising and spreading effectively, the dynamical behavior of a SIRS model with saturated contact rate and pulse vaccination is investigated. Using Floquet theory and comparison theorem of impulsive differential equation, the existence and globally asymptotically stability of infection-free periodic solution are proven. Using bifurcation theory, the bifurcation parameter for the existence of positive periodic solution is obtained. The result indicates that the disease will die out if \u03b8 > \u03b8* (or \u03c4 < \u03c4*), whereas the system is uniformly persistent if \u03c4 > \u03c40, which means that after some period of time the disease will become endemic.",
        "keywords": [
            "Globally asymptotically stability",
            "Periodic solution",
            "Pulse",
            "SIRS model",
            "Vaccination"
        ],
        "authors": [
            {
                "name": "PANG Guo-ping",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            },
            {
                "name": "TAO Feng-mei",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            },
            {
                "name": "CHEN Lan-sun",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            }
        ],
        "venue": "Dalian Ligong Daxue Xuebao/Journal of Dalian University of Technology",
        "year": 2007
    },
    "v1yFIKha": {
        "id": "v1yFIKha",
        "title": "IMPULSIVE DISPERSAL OF PLANT SEEDS IN SINGLE SPECIES MODEL",
        "abstract": "",
        "keywords": [
            "global stability",
            "impulsive diffusion",
            "persistence",
            "stroboscope map"
        ],
        "authors": [
            {
                "name": "LIMIN WANG",
                "org": ""
            },
            {
                "name": "YUANSHUN TAN",
                "org": ""
            },
            {
                "name": "LANSUN CHEN",
                "org": ""
            }
        ],
        "venue": "Journal of Biological Systems",
        "year": 2007
    },
    "pRz8MYLH": {
        "id": "pRz8MYLH",
        "title": "Original article: Modelling and qualitative analysis of a predator-prey system with state-dependent impulsive effects",
        "abstract": "In this work, according to integrated pest management principles, a class of predator-prey system with state-dependent impulsive effects is put forward. In this model, the control strategies by releasing natural enemies and spraying pesticide at different thresholds are considered. The sufficient conditions for the existence and stability of the semi-trivial periodic solution and the positive order-1 periodic solution are given by the Poincare map and the properties of the Lambert W function. In addition, to verify the feasibility of our main results, the numerical simulations are carried out.",
        "keywords": [
            "semi-trivial periodic solution",
            "state-dependent impulsive effect",
            "natural enemy",
            "qualitative analysis",
            "different threshold",
            "main result",
            "original article",
            "Poincare map",
            "Lambert W function",
            "order-1 periodic solution",
            "integrated pest management principle",
            "numerical simulation",
            "predator-prey system",
            "control strategy"
        ],
        "authors": [
            {
                "name": "Yuan Tian",
                "org": "School of Information Engineering, Dalian University, Dalian 116622, People's Republic of China"
            },
            {
                "name": "Kaibiao Sun",
                "org": "School of Control Science and Engineering, Dalian University of Technology, Dalian 116024, People's Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "School of Mathematical Science, Dalian University of Technology, Dalian 116024, People's Republic of China"
            }
        ],
        "venue": "Mathematics and Computers in Simulation",
        "year": 2011
    },
    "GHQFk1bF": {
        "id": "GHQFk1bF",
        "title": "Qualitative analysis and applications of a kind of state-dependent impulsive differential equations",
        "abstract": "This paper analyzes a certain type of impulsive differential equations (IDEs). Several useful theorems for its periodic solutions and their stabilities are given. The key idea is that a periodically time-dependent IDE can be transformed into the state-dependent IDE. As applications of our theory, the optimization problems in population dynamics are studied. That is, the maximum sustainable yields of single population models with periodically impulsive constant harvesting are discussed. Furthermore, we apply these results to the studies of the order-1 periodic solutions and their stability of a single population model with stage structure in which the mature is impulsively proportionally harvested while the immature is impulsively added with the constant.",
        "keywords": [
            "periodic solution",
            "population dynamic",
            "state-dependent ide",
            "impulsively proportionally",
            "state-dependent impulsive differential equation",
            "impulsive constant harvesting",
            "time-dependent ide",
            "certain type",
            "order-1 periodic solution",
            "impulsive differential equation",
            "qualitative analysis",
            "single population model",
            "optimization problem",
            "population models",
            "population model",
            "dynamic system",
            "asymptotically stable"
        ],
        "authors": [
            {
                "name": "Fengyan Wang",
                "org": "College of Science, Jimei University, Xiamen Fujian 361021, PR China"
            },
            {
                "name": "Guoping Pang",
                "org": "Department of Mathematics and Computer Science, Yulin Normal University, Yulin Guangxi 537000, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, PR China"
            }
        ],
        "venue": "Journal of Computational and Applied Mathematics",
        "year": 2008
    },
    "iOlzHwie": {
        "id": "iOlzHwie",
        "title": "Dynamical analysis of a chemostat model with delayed response in growth and pulse input in polluted environment",
        "abstract": "In this paper, a chemostat model with delayed response in growth and pulse input in polluted environment is considered. Using\n the discrete dynamical system determined by the stroboscopic map, we obtain a microorganism-extinction periodic solution.\n Further, it is globally attractive. The permanent condition of the investigated system is also obtained by the theory on impulsive\n delay differential equation. Our results reveal that the delayed response in growth plays an important role on the outcome\n of the chemostat.",
        "keywords": [
            "Chemostat model",
            "Delayed response in growth",
            "Pulse input in polluted environment",
            "Extinction",
            "Permanence"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": "Guizhou Key Laboratory of Economic System Simulation, Guizhou College of Finance & Economics School of Mathematics and Statistics Guiyang 550004 People\u2019s Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and System Sciences Institute of Mathematics Beijing 100080 People\u2019s Republic of China"
            }
        ],
        "venue": "Journal of Mathematical Chemistry",
        "year": 2009
    },
    "pOzutOAo": {
        "id": "pOzutOAo",
        "title": "The dynamics of an epidemic model for pest control with impulsive effect",
        "abstract": "In pest control, there are only a few papers on mathematical models of the dynamics of microbial diseases. In this paper a model concerning biologically-based impulsive control strategy for pest control is formulated and analyzed. The paper shows that there exists a globally stable susceptible pest eradication periodic solution when the impulsive period is less than some critical value. Further, the conditions for the permanence of the system are given. In addition, there exists a unique positive periodic solution via bifurcation theory, which implies both the susceptible pest and the infective pest populations oscillate with a positive amplitude. In this case, the susceptible pest population is infected to the maximum extent while the infective pest population has little effect on the crops. When the unique positive periodic solution loses its stability, numerical simulation shows there is a characteristic sequence of bifurcations, leading to a chaotic dynamic, which implies that this model has more complex dynamics, including period-doubling bifurcation, chaos and strange attractors.",
        "keywords": [
            "global stability",
            "permanence",
            "existence of positive periodic solution",
            "pest control",
            "oscillations",
            "mathematical model",
            "strange attractor",
            "numerical simulation",
            "complex dynamics",
            "bifurcation theory",
            "critical value",
            "epidemic model"
        ],
        "authors": [
            {
                "name": "Limin Wang",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, 116024 Dalian Liaoning, PR China"
            },
            {
                "name": "Juan J. Nieto",
                "org": "Departamento de Analisis Matematico, Facultad de Matematicas, Universidad de, Santiago de Compostela, 15782 Santiago de Compostela, Spain"
            }
        ],
        "venue": "Nonlinear Analysis: Real World Applications",
        "year": 2010
    },
    "owjSL7s2": {
        "id": "owjSL7s2",
        "title": "Oscillation Criteria for a Class of Second-Order impulsive Delay Difference Equations",
        "abstract": "",
        "keywords": [
            "delay",
            "difference equation",
            "impulsive",
            "oscillation",
            "oscillations",
            "second order"
        ],
        "authors": [
            {
                "name": "Hong Zhang",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Advances in Complex Systems",
        "year": 2006
    },
    "yZg4WXQl": {
        "id": "yZg4WXQl",
        "title": "Global asymptotic stability of the periodic Lotka-Volterra System with two-predators and one-prey",
        "abstract": "The three species Lotka-Volterra periodic model with two predators and one prey is considered. A set of easily verifiable\n sufficient conditions is obtained. Finally, and example is given to illustrate the feasibility of these conditions.",
        "keywords": [
            "Primary 34C27",
            "Secondary 34D05",
            "Periodic",
            "existence",
            "global asymptotic stability"
        ],
        "authors": [
            {
                "name": "Lu Zhonghua",
                "org": "Xi\u2019an Statistic College 710061 Xi\u2019an"
            },
            {
                "name": "Chen Lansun",
                "org": "Academia Sinica Institute of Mathematics 100080 Beijing"
            }
        ],
        "venue": "Applied Mathematics-a Journal of Chinese Universities Series B",
        "year": 1995
    },
    "VTgpderT": {
        "id": "VTgpderT",
        "title": "Stage-Structured Impulsive SI Model for Pest Management",
        "abstract": "",
        "keywords": [
            "pest management"
        ],
        "authors": [
            {
                "name": "Ruiqing Shi",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Discrete Dynamics in Nature and Society",
        "year": 2007
    },
    "ZgGmMgFY": {
        "id": "ZgGmMgFY",
        "title": "Persistence and Global Stability for a Delayed Nonautonomous Predator\u2013Prey System without Dominating Instantaneous Negative Feedback",
        "abstract": "A delayed nonautonomous three-species predator\u2013prey Lotka\u2013Volterra system without dominating instantaneous negative feedback is investigated. It is proved that the system is uniformly persistent under appropriate conditions. By constructing a suitable Lyapunov functional, sufficient conditions are derived for the global stability of the system.",
        "keywords": [
            "lyapunov functional",
            "uniform persistence",
            "global stability",
            "delay",
            "negative feedback",
            "lyapunov function"
        ],
        "authors": [
            {
                "name": "Rui Xu",
                "org": "Department of Mathematics, Mechanical Engineering College, Shijiazhuang, 050003, People's Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academia Sinica, Beijing, 100080, People's Republic of China"
            }
        ],
        "venue": "Journal of Mathematical Analysis and Applications",
        "year": 2001
    },
    "bpOBXEEg": {
        "id": "bpOBXEEg",
        "title": "Global asymptotic stability of a two species competitive system with stage structure and harvesting",
        "abstract": "",
        "keywords": [
            "competitive system",
            "global asymptotic stability",
            "optimal harvesting",
            "stage structure"
        ],
        "authors": [
            {
                "name": "xinvu song",
                "org": ""
            },
            {
                "name": "lansun chen",
                "org": "institute of mathematics"
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2001
    },
    "D4t37I95": {
        "id": "D4t37I95",
        "title": "Dynamical Analysis of a Three-Dimensional predator-prey Model with impulsive Harvesting and Diffusion",
        "abstract": "",
        "keywords": [
            "extinction",
            "Impulsive diffusion",
            "impulsive harvesting",
            "permanence",
            "predator-prey model"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": ""
            },
            {
                "name": "Shaohong Cai",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "I. J. Bifurcation and Chaos",
        "year": 2011
    },
    "9j3pHhPc": {
        "id": "9j3pHhPc",
        "title": "Global attractivity of positive periodic solutions for nonlinear impulsive systems",
        "abstract": "In this paper, the existence, uniqueness and global attractivity of positive periodic solutions for nonlinear impulsive systems are studied. Firstly, existence conditions are established by the method of lower and upper solutions. Then uniqueness and global attractivity are obtained by developing the theories of monotone and concave operators. And lastly, the method and the results are applied to the impulsive n -species cooperative Lotka\u2013Volterra system and a model of a single-species dispersal among n -patches.",
        "keywords": [
            "global attractivity",
            "concave operators",
            "impulse",
            "periodic solutions",
            "cooperative systems"
        ],
        "authors": [
            {
                "name": "Xianning Liu",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Academia Sinica, Beijing, 100080, PR China"
            }
        ],
        "venue": "Nonlinear Analysis",
        "year": 2006
    },
    "A1TXYyIg": {
        "id": "A1TXYyIg",
        "title": "Optimal harvesting and stability for a two-species competitive system with stage structure.",
        "abstract": "In this paper, we consider a stage-structured competitive population model with two life stages, immature and mature, with a mature population of harvesting. We obtain conditions for the existence of a globally asymptotically stable positive equilibrium and a threshold of harvesting for the mature population. The optimal harvesting of the mature population is also considered.",
        "keywords": [
            "stage structure",
            "34c25",
            "optimal harvesting",
            "competitive system",
            "34d20",
            "92d25",
            "equilibrium stability",
            "population model"
        ],
        "authors": [
            {
                "name": "X Song",
                "org": "Institute of Mathematics, Academia Sinica, Beijing 100080, People's Republic of China"
            },
            {
                "name": "L Chen",
                "org": ""
            }
        ],
        "venue": "Mathematical biosciences",
        "year": 2001
    },
    "gAONXsw9": {
        "id": "gAONXsw9",
        "title": "Chemical chaos in enzyme kinetics",
        "abstract": "In this paper, the effect of impulsive perturbation on enzyme kinetics is investigated. The impulsive perturbation is affected\n by introducing periodic constant input. The dynamical behavior of system is simulated and bifurcation diagrams are obtained.\n The results show that impulsive perturbation can easily give rise to complex dynamics, which includes: quasi-periodic oscillation,\n periodic doubling cascade, periodic halving cascade, attractor crisis and chaotic bands with periodic windows.",
        "keywords": [
            "Periodic solution",
            "Quasi-periodic oscillation",
            "Limit cycle",
            "Bifurcation",
            "Chaos"
        ],
        "authors": [
            {
                "name": "Zhong Zhao",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116024 China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116024 China"
            }
        ],
        "venue": "Nonlinear Dynamics",
        "year": 2009
    },
    "IzLfvY3D": {
        "id": "IzLfvY3D",
        "title": "The dynamics of an impulsive delay SI model with variable coefficients",
        "abstract": "An impulsive delayed SI model with variable coefficients and a nonlinear incidence is formulated and analyzed. By introducing three thresholds, we obtain sufficient conditions for eradication and permanence of the disease, respectively. It is shown that the conditions depend on time delay for both the global attractivity of the positive infection-free periodic solution and permanence of the model. Furthermore, our results indicate that the disease will disappear if the ratio of the maximum to minimum of the pulse vaccination rate is lager than some value. The main feature of this paper is that we introduce multi-delays and variable coefficients into the SI model, and exhibit a new method which is applied to investigate this model. Numerical results show that the system we considered has complex dynamics including periodic and quasi-periodic oscillations.",
        "keywords": [
            "Global attractivity",
            "Permanence",
            "Time delay",
            "SI model",
            "Impulse"
        ],
        "authors": [
            {
                "name": "Yongzhen Pei",
                "org": ""
            },
            {
                "name": "Shaoying Liu",
                "org": "School of Science, Tianjin Polytechnic University, Tianjin 300160, China"
            },
            {
                "name": "Changguo Li",
                "org": "Department of Basic Science, Institute of Military Traffic, Tianjin 300161, China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116023, China"
            }
        ],
        "venue": "Applied Mathematical Modelling",
        "year": 2009
    },
    "taotS5Uq": {
        "id": "taotS5Uq",
        "title": "A delay SIR epidemic model with pulse vaccination and incubation times",
        "abstract": "In this paper, a new delay SIR epidemic model with pulse vaccination and incubation times is considered. We obtain an infection-free semi-trivial periodic solution and establish the sufficient conditions for the global attractivity of the semi-trivial periodic solution. By use of new computational techniques for impulsive differential equations with delay, we prove that the system is permanent under appropriate conditions. The results show that time delay, pulse vaccination and nonlinear incidence have significant effects on the dynamics behaviors of the model. Our results are illustrated and corroborated with some numerical experiments.",
        "keywords": [
            "sir epidemic model",
            "time delay",
            "permanence",
            "nonlinear incidence",
            "pulse vaccination",
            "epidemic model"
        ],
        "authors": [
            {
                "name": "Xinzhu Meng",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and System Sciences, Chinese Academy of Sciences, Beijing, 100080, PR China"
            },
            {
                "name": "Bo Wu",
                "org": "College of Science, Shandong University of Science and Technology, Qingdao 266510, PR China"
            }
        ],
        "venue": "Nonlinear Analysis: Real World Applications",
        "year": 2010
    },
    "22g1nRLt": {
        "id": "22g1nRLt",
        "title": "Global Dynamics Behaviors of Viral Infection Model for Pest Management",
        "abstract": "",
        "keywords": [
            "pest management"
        ],
        "authors": [
            {
                "name": "Chunjin Wei",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Discrete Dynamics in Nature and Society",
        "year": 2009
    },
    "gpOOh43V": {
        "id": "gpOOh43V",
        "title": "Dynamical analysis of a five-dimensioned chemostat model with impulsive diffusion and pulse input environmental toxicant",
        "abstract": "In this paper, we consider a five-dimensioned chemostat model with impulsive diffusion and pulse input environmental toxicant. Using the discrete dynamical system determined by the stroboscopic map, we obtain a microorganism-extinction periodic solution. Further, it is globally asymptotically stable. The permanent condition of the investigated system is also analyzed by the theory on impulsive differential equation. Our results reveal that the chemostat environmental changes play an important role on the outcome of the chemostat.",
        "keywords": [
            "environmental change",
            "dynamic analysis"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": ""
            },
            {
                "name": "Kaili Ye",
                "org": "School of Economics and Management, Xinyang Normal University, Xinyang 464000, Henan, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Beijing 100080, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2011
    },
    "K03Hb7zd": {
        "id": "K03Hb7zd",
        "title": "Global stability for a delayed ratio-dependent predator-prey system without dominating instantaneous negative feedbacks",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "rui xu",
                "org": ""
            },
            {
                "name": "m a j chaplain",
                "org": ""
            },
            {
                "name": "lansun chen",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2001
    },
    "PAXRgZUu": {
        "id": "PAXRgZUu",
        "title": "Species extinction and permanence in a prey\u2013predator model with two-type functional responses and impulsive biological control",
        "abstract": "By introducing impulsive biological control strategy, the dynamic behaviors of the two-prey one-predator model with defensive\n ability and Holling type-II functional response are investigated. By using Floquet\u2019s Theorem and the small amplitude perturbation\n method, we prove that there exists an asymptotically stable pest-eradication periodic solution when the impulsive period is\n less than some critical minimum value, and permanence conditions (that is, the impulsive period is greater than some critical\n maximum value) are established via the method of comparison involving multiple Liapunov functions. It is shown that our impulsive\n control strategy is more effective than the classical one. Furthermore, the effect of impulsive perturbations on the unforced\n continuous system is studied. From simulations, we find that the system has more complex dynamic behaviors and is dominated\n by periodic, quasi-periodic, and chaotic solutions.",
        "keywords": [
            "Impulsive biological control",
            "Functional response",
            "Extinction",
            "Permanence",
            "Quasi-periodic solution"
        ],
        "authors": [
            {
                "name": "Yongzhen Pei",
                "org": "Tianjin Polytechnic University School of Science Tianjin 300161 China"
            },
            {
                "name": "Guangzhao Zeng",
                "org": "ShaoGuan University Department of Mathematics ShaoGuan GuangDong 512005 China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116023 China"
            }
        ],
        "venue": "Nonlinear Dynamics",
        "year": 2008
    },
    "X4f59f1e": {
        "id": "X4f59f1e",
        "title": "Comment on \"Existence and stability of periodic solution of a LotkaVolterra predatorprey model with state dependent impulsive effects\" [J. Comput. Appl. Math. 224 (2009) 544555]",
        "abstract": "In this paper, according to integrated pest management principles, a class of LotkaVolterra predatorprey model with state dependent impulsive effects is presented. In this model, the control strategies by releasing natural enemies and spraying pesticide at different thresholds are considered. The sufficient conditions for the existence and stability of the positive order-1 periodic solution are given by the Poincar\u00e9 map and the properties of the LambertW function. \u00a9 2010 Elsevier B.V. All rights reserved.",
        "keywords": [
            "Impulsive differential equations",
            "LotkaVolterra predatorprey system",
            "Periodic solution",
            "State-dependent"
        ],
        "authors": [
            {
                "name": "Yuan Tian",
                "org": "Dalian University(Dalian University),Dalian,China"
            },
            {
                "name": "KaiBiao Sun",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            }
        ],
        "venue": "Journal of Computational and Applied Mathematics",
        "year": 2010
    },
    "J7rGg1nw": {
        "id": "J7rGg1nw",
        "title": "Impulsive State Feedback Control of Cheese Whey Fermentation for Single-Cell Protein Production.",
        "abstract": "The work is the analysis of a mathematical model of cheese whey fermentation for single-cell protein production with impulsive state feedback control. Through the analysis, the sufficient conditions of existence and stability of positive order-1 periodic solution are obtained. It is shown that the system either tends to a stable state or has a periodic solution, which depends on the feedback state, the control parameter of the dilution rate, and the initial concentrate of microorganism and substrate. For some special cases, it is also shown that the system may exist in order-2 periodic solution. Furthermore, our findings are confirmed by means of numerical simulations. \u00a9 2013 Chunjin Wei et al.",
        "keywords": [],
        "authors": [
            {
                "name": "Chunjin Wei",
                "org": ""
            },
            {
                "name": "Shuwen Zhang",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "J. Applied Mathematics",
        "year": 2013
    },
    "DAzP6Upr": {
        "id": "DAzP6Upr",
        "title": "How Do the Spatial Structure and Time Delay Affect the Persistence of A Polluted Species",
        "abstract": "",
        "keywords": [
            "logistic growth",
            "extinction",
            "diffusion"
        ],
        "authors": [
            {
                "name": "Yanni Xiao",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Applicable Analysis",
        "year": 2003
    },
    "AKRMlU6l": {
        "id": "AKRMlU6l",
        "title": "A delayed stage-structured Holling II predator\u2013prey model with mutual interference and impulsive perturbations on predator",
        "abstract": "In this work, we investigate a delayed stage-structured Holling II predator\u2013prey model with mutual interference and impulsive perturbations on predator. Sufficient conditions of the global attractivity of prey-extinction periodic solution and the permanence of the system are obtained. We also prove that all solutions of the system are uniformly ultimately bounded. Our results provide reliable tactical basis for the practical pest management.",
        "keywords": [
            "pest management"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, People\u2019s Republic of China"
            },
            {
                "name": "Shaohong Cai",
                "org": "Guizhou College of Finance and Economics, Guiyang 550004, People\u2019s Republic of China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2009
    },
    "l3JhUl9C": {
        "id": "l3JhUl9C",
        "title": "The dynamical behaviors of a Lotka\u2013Volterra predator\u2013prey model concerning integrated pest management",
        "abstract": "According to the fact integrated pest management, a Lotka\u2013Volterra predator-prey model with impulsive effect at fixed moment is proposed and investigated. We analyze such system from two cases: general case (taking IPM strategy) and special case (only choosing pesticides). In the first case, we show that there exists a globally asymptotically stable pest-eradication periodic solution when the period of impulsive effect is less than some critical value. The condition for the permanence is also given. By using bifurcation theory, we show the existence and stability of positive periodic solution when the pest-eradication lost its stability. In the second case, the system by only choosing chemical pesticides, we give the conditions of existence and stability of predator-free periodic solution. We obtain that the conditions for the permanence or extinction in the system we considered are quite different from the corresponding system without impulse. Finally, we compare validity of the IPM strategy with the classical methods (only biological control or chemical control), and conclude that IPM strategy is more effective than the classical one.",
        "keywords": [
            "permanence",
            "extinction",
            "ipm strategy",
            "lotka\u2013volterra predator\u2013prey model",
            "impulsive effect",
            "bifurcation",
            "critical value",
            "bifurcation theory",
            "integrated pest management",
            "biological control"
        ],
        "authors": [
            {
                "name": "Bing Liu",
                "org": ""
            },
            {
                "name": "Yujuan Zhang",
                "org": "Department of Mathematics, Anshan Normal University, Anshan, Liaoning 114005, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Beijing 100080, PR China"
            }
        ],
        "venue": "Nonlinear Analysis: Real World Applications",
        "year": 2005
    },
    "yP3a9fek": {
        "id": "yP3a9fek",
        "title": "A NEW MATHEMATICAL MODEL FOR OPTIMAL CONTROL STRATEGIES OF INTEGRATED PEST MANAGEMENT",
        "abstract": "",
        "keywords": [
            "biological and mechanical control",
            "economic threshold",
            "impulsive effect",
            "periodic solution",
            "si epidemic model",
            "mathematical model",
            "optimal control",
            "integrated pest management"
        ],
        "authors": [
            {
                "name": "XINZHU MENG",
                "org": ""
            },
            {
                "name": "ZHITAO SONG",
                "org": ""
            },
            {
                "name": "LANSUN CHEN",
                "org": ""
            }
        ],
        "venue": "Journal of Biological Systems",
        "year": 2007
    },
    "RRXfjNPK": {
        "id": "RRXfjNPK",
        "title": "Optimal harvesting policies for periodic Gompertz systems",
        "abstract": "In this paper, we study the periodic Gompertz system with harvesting. First, we analyze the system with continuous harvesting and obtain the maximum annual-sustainable yield, the optimal harvesting effort and the optimal population level for such a system. Then, the harvesting is assumed to occur at fixed moments every year, and we establish the Gompertz system with impulsive perturbation. And we investigate the impulsive harvesting policy to maximize the annual yield and to keep the population sustainable development. At last, the optimal results of the impulsive harvesting system are compared with those of the continuous harvesting system.",
        "keywords": [
            "the optimal harvesting policy",
            "impulsive harvesting",
            "continuous harvesting",
            "sustainable development"
        ],
        "authors": [
            {
                "name": "Lingzhen Dong",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116023, China"
            },
            {
                "name": "Lihua Sun",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116023, China"
            }
        ],
        "venue": "Nonlinear Analysis: Real World Applications",
        "year": 2007
    },
    "I6ydB7CZ": {
        "id": "I6ydB7CZ",
        "title": "Dynamic analysis of a kind of species control model concerning impulsively releasing pathogen and infective predator",
        "abstract": "A kind of species control model concerning impulsive releasing pathogen and infective predator is presented. By using the Floquet theory and comparison theorem of impulsive differential equation, the extinction and permanence of system are discussed and the corresponding conditions are obtained, respectively. Finally, the practical meanings of those conditions are explained and the theoretical results are confirmed by numerical simulations. Besides, with the period of impulsive release varying, the numerical simulations also show that the system displays a series of complex phenomena which include period-doubling cascade, chaos and periodic window, etc.",
        "keywords": [
            "numerical simulation",
            "floquet theory",
            "dynamic analysis"
        ],
        "authors": [
            {
                "name": "Hongjian Guo",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, PR China"
            },
            {
                "name": "Xinyu Song",
                "org": "Department of Mathematics, Xinyang Normal University, Xinyang 464000, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2009
    },
    "2jRI05xs": {
        "id": "2jRI05xs",
        "title": "Permanence and Global Stability for Single-species Model with Three Life Stages and Time Delay",
        "abstract": "In this paper,a single-species model with distributed time delay in which individuals exhibit three life stages is considered.Sufficient conditions are obtained for the permanence of the system.Moreover,by using Lyapunov function,some conditions for global asymptotic stability of the system are investigated.An example satisfying the conditions of the main resuilts is given.",
        "keywords": [
            "Time delay",
            "Global asymptotic stability",
            "Permanence",
            "Stage structure"
        ],
        "authors": [
            {
                "name": "Gao Shujing",
                "org": "Department of Applied Mathematics,Dalian University of Technology,Dalian "
            },
            {
                "name": "Chen Lansun",
                "org": "Department of Applied Mathematics,Dalian University of Technology,Dalian "
            }
        ],
        "venue": "Acta Mathematica Scientia",
        "year": 2006
    },
    "geuskxEw": {
        "id": "geuskxEw",
        "title": "Recent progress on stage-structured population dynamics \u2606",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shengqiang liu",
                "org": ""
            },
            {
                "name": "lansun chen",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2002
    },
    "4xsrkNxA": {
        "id": "4xsrkNxA",
        "title": "Nonlinear incidence rate of a pest management SI model with impulsive control strategy",
        "abstract": "In this work,we consider a pest management SI modelwith concerns about releasing of infective pests and spraying pesticides at different fixed moments. We prove that all solutions the investigated system are uniformly ultimately bounded, and there exists globally asymptotic stable pest-extinction boundary periodic solution when certain condition is satisfied. Furthermore, the permanent condition of the system is also obtained. It is concluded that the approach, which combines releasing infective pestswith spraying pesticides in different fixed moments, provides reliable tactic basis for the practical pest management. Copyright \u00a9 2009 John Wiley & Sons, Ltd.",
        "keywords": [
            "impulsive",
            "infective pests",
            "permanence",
            "pest-extinction",
            "incidence rate",
            "pest management"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": "Guizhou College of Finance and Economics(Guizhou College of Finance and Economics),Guiyang,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            }
        ],
        "venue": "Mathematical Methods in the Applied Sciences",
        "year": 2010
    },
    "z7eBdaYF": {
        "id": "z7eBdaYF",
        "title": "WITHDRAWN: The analysis of two-nutrient and one-microorganism chemostat model with time delay and pulsed input",
        "abstract": "",
        "keywords": [
            "critical value",
            "numerical analysis"
        ],
        "authors": [
            {
                "name": "Zhong Zhao",
                "org": ""
            },
            {
                "name": "Xiuquan Zhang",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2009
    },
    "HDyKXwxI": {
        "id": "HDyKXwxI",
        "title": "ANALYSIS OF PERIODIC PREDATOR-PREY SYSTEM WITH DISPERSAL",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "hua li",
                "org": ""
            },
            {
                "name": "jingan cui",
                "org": ""
            },
            {
                "name": "lansun chen",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2004
    },
    "7Q3Fj97w": {
        "id": "7Q3Fj97w",
        "title": "The effect of seasonal harvesting on a single-species discrete population model with stage structure and birth pulses",
        "abstract": "In this paper, we propose an exploited single-species discrete model with stage structure for the dynamics in a fish population for which births occur in a single pulse once per time period. Using the stroboscopic map, we obtain an exact cycle of the system, and obtain the threshold conditions for its stability. Bifurcation diagrams are constructed with the birth rate as the bifurcation parameter, and these are observed to display complex dynamic behaviors, including chaotic bands with period windows, pitch-fork and tangent bifurcation. This suggests that birth pulse provides a natural period or cyclicity that makes the dynamical behavior more complex. Moreover, we show that the timing of harvesting has a strong impact on the persistence of the fish population, on the volume of mature fish stock and on the maximum annual-sustainable yield. An interesting result is obtained that, after the birth pulse, the earlier culling the mature fish, the larger harvest can tolerate.",
        "keywords": [
            "complex dynamics",
            "seasonality",
            "bifurcation diagram",
            "population model"
        ],
        "authors": [
            {
                "name": "Shujing Gao",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2005
    },
    "OngtXkCl": {
        "id": "OngtXkCl",
        "title": "DYNAMIC BEHAVIORS OF A KIND OF PREDATOR\u2013PREY SYSTEM WITH IVLEV'S AND BEDDINGTON\u2013DEANGELIS' FUNCTIONAL RESPONSE AND IMPULSIVE RELEASE",
        "abstract": "",
        "keywords": [
            "bifurcation",
            "extinction",
            "impulsive effect",
            "permanence",
            "predator - prey system",
            "functional response"
        ],
        "authors": [
            {
                "name": "HONGJIAN GUO",
                "org": ""
            },
            {
                "name": "XINYU SONG",
                "org": ""
            },
            {
                "name": "LANSUN CHEN",
                "org": ""
            }
        ],
        "venue": "Stochastics and Dynamics",
        "year": 2008
    },
    "FrwnxTsF": {
        "id": "FrwnxTsF",
        "title": "Dynamic Complexities in a Lotka-volterra Predator-prey Model Concerning impulsive Control Strategy",
        "abstract": "",
        "keywords": [
            "Bifurcation",
            "Extinction and permanence",
            "Impulsive perturbation",
            "Predator-prey model"
        ],
        "authors": [
            {
                "name": "Bing Liu",
                "org": ""
            },
            {
                "name": "Yujuan Zhang",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "I. J. Bifurcation and Chaos",
        "year": 2005
    },
    "v1lxRroo": {
        "id": "v1lxRroo",
        "title": "GLOBAL ANALYSIS OF AN SEIR EPIDEMIC DISEASE MODEL WITH VERTICAL TRANSMISSION AND PULSE VACCINATION",
        "abstract": "In this paper,an SEIR epidemic disease model with integral delay and vertical transmission is considered,and dynamics behaviors of the model under pulse vaccination are analyzed.The sufficient condition for infection-extinction is obtained.Then,by using the theory on delay functional and impulsive differential equation theory,the sufficient condition of the permanence for the system with time delay is given.Finally,it is shown that time delays and pulse vaccination can bring obvious effects on the dynamics behaviors of the model.",
        "keywords": [
            "integral delays",
            "Vertical transmission",
            "pulse vaccination",
            "permanence",
            "global attractivity"
        ],
        "authors": [
            {
                "name": "LIU Kaiyuan",
                "org": "Department of Applied Mathematics,Dalian University of Technology,Dalian "
            },
            {
                "name": "CHEN Lansun",
                "org": "Department of Applied Mathematics,Dalian University of Technology,Dalian "
            }
        ],
        "venue": "Journal of Systems Science and Mathematical Sciences",
        "year": 2010
    },
    "Yf3qStO2": {
        "id": "Yf3qStO2",
        "title": "THE PERIODIC PREDATOR-PREY LOTKA\u2013VOLTERRA MODEL WITH IMPULSIVE EFFECT",
        "abstract": "",
        "keywords": [
            "persistence",
            "biological control",
            "bifurcation"
        ],
        "authors": [
            {
                "name": "sanyi tang",
                "org": ""
            },
            {
                "name": "lansun chen",
                "org": ""
            }
        ],
        "venue": "Journal of Mechanics in Medicine and Biology",
        "year": 2011
    },
    "e5sGZc0S": {
        "id": "e5sGZc0S",
        "title": "A Single Species Model with Impulsive Diffusion",
        "abstract": "",
        "keywords": [
            "numerical simulation",
            "population dynamic",
            "fixed point"
        ],
        "authors": [
            {
                "name": "jing hui",
                "org": "east china normal university"
            },
            {
                "name": "lansun chen",
                "org": "dalian university of technology"
            }
        ],
        "venue": "Acta Mathematicae Applicatae Sinica",
        "year": 2005
    },
    "lY8s89L5": {
        "id": "lY8s89L5",
        "title": "Asymptotic behaviors of competitive Lotka\u2013Volterra system with stage structure",
        "abstract": "In this paper, a two-species competitive model with stage structure is presented and studied. Results on the global extinction and permanence are given, which generalize the well-known three theorems for the two species competitive system and, moreover, they confirm the negative effect of stage structure on the permanence of populations as well as estimate the degree of such effect. Conclusions in this paper suggest that for a competitive community stage structure is also one of the important reasons that cause permanence and extinction.",
        "keywords": [
            "permanence",
            "time delay",
            "lotka\u2013volterra",
            "extinction",
            "stage structure",
            "competitive"
        ],
        "authors": [
            {
                "name": "Shengqiang Liu",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and System Sciences, Academia Sinica, Beijing, 100080, People's Republic of China"
            },
            {
                "name": "Guilie Luo",
                "org": "Department of Mathematics, Guangxi Normal University, 541004, People's Republic of China"
            },
            {
                "name": "Youlin Jiang",
                "org": "Yulin Teacher's College, Yulin, Guangxi Province, People's Republic of China"
            }
        ],
        "venue": "Journal of Mathematical Analysis and Applications",
        "year": 2002
    },
    "8Q0GDGru": {
        "id": "8Q0GDGru",
        "title": "Global dynamical behaviors for an SIR epidemic model with time delay and pulse vaccination",
        "abstract": "Since the investigation of impulsive delay differential equations are inchoate, the literature on delay epidemic models with pulse vaccination is not extensive. In this paper, we propose a delay SIR epidemic model with impulsive effect and analyze the global dynamics behaviors of the model. Using the discrete dynamical system determined by the stroboscopic map, we show that there exists an 'infection-free' periodic solution in the model. Further, we prove that the 'infection-free' periodic solution is globally attractive when the period of impulsive effect is less than some critical value. The condition for the permanence of population for epidemic model with pulse vaccination is given, which means the epidemic disease to spread around. We conclude that time delay and pulse bring great effects on the dynamics of the model. It illustrated theoretically that we should look carefully after the infectious patients to shorten the convalescence period (or infections period). Lastly, the biologic discussion and strategy for the elimination of infectious diseases are also given. In this paper, the main feature is that we introduce time delay together with pulse into epidemic model, and we investigate their effects on the dynamics of model.",
        "keywords": [
            "global attractivity",
            "horizontal and vertical transmission",
            "permanence",
            "pulse vaccination",
            "time delay"
        ],
        "authors": [
            {
                "name": "Xinzhu Meng",
                "org": "Shandong University of Science and Technology(Shandong University of Science and Technology,Shandong Univ. of Sci. and Technol.),Qingdao,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and System Sciences Chinese Academy of Sciences(Chinese Academy of Sciences,Academy of Mathematics and Systems Science),Beijing,China"
            }
        ],
        "venue": "Taiwanese Journal of Mathematics",
        "year": 2008
    },
    "DvbGyq5P": {
        "id": "DvbGyq5P",
        "title": "A MODEL FOR TWO SPECIES WITH STAGE STRUCTURE AND FEEDBACK CONTROL",
        "abstract": "",
        "keywords": [
            "extinction",
            "functional response",
            "infinite delay",
            "permanence",
            "predator-prey system",
            "stage structure",
            "feedback control"
        ],
        "authors": [
            {
                "name": "HONG ZHANG",
                "org": ""
            },
            {
                "name": "LANSUN CHEN",
                "org": ""
            }
        ],
        "venue": "International Journal of Biomathematics",
        "year": 2008
    },
    "fkAjh85W": {
        "id": "fkAjh85W",
        "title": "The effects of impulsive toxicant input on a population in a polluted environment",
        "abstract": "In this paper, we investigate a single species model in a polluted closed environment with pulse toxicant input at fixed moment. We show that the population is extinct when the impulsive period is less than some critical value, otherwise the population is permanent, and the permanent condition also assure that there exists a unique positive periodic solution which is globally asymptotically stable. By comparing with the continuous system, we show that pulse toxicant input cause a periodic behavior in our system and oscillation of the solution. From the biological point of view, it is easy to protect species by changing impulsive period of the exogenous input of toxicant, and toxicant input amount, etc. Further, the effects of environmental noise on the population are studied by using numerical methods.",
        "keywords": [
            "environmental noise",
            "extinction",
            "globally asymptotic stability",
            "impulsive effect",
            "permanence"
        ],
        "authors": [
            {
                "name": "Bing Liu",
                "org": "Anshan Normal University(Anshan Normal University,Anshan Normal College),Anshan,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and System Sciences Chinese Academy of Sciences(Chinese Academy of Sciences,Academy of Mathematics and Systems Science),Beijing,China"
            },
            {
                "name": "Yujuang Zhang",
                "org": "Anshan Normal University(Anshan Normal University,Anshan Normal College),Anshan,China"
            }
        ],
        "venue": "Journal of Biological Systems",
        "year": 2003
    },
    "hNhW4cKi": {
        "id": "hNhW4cKi",
        "title": "The dynamics of an impulsive delay predator\u2013prey model with variable coefficients",
        "abstract": "In this paper, we formulate a new robust two-species nonautonomous predator\u2013prey model with multi-delays and impulsive effects and perform a systematic mathematical and ecological study. Our results in this paper indicate that under the appropriate linear periodic impulsive perturbations, the system is permanent and has a unique positive globally attractive semi-trivial periodic solution. By using the Brouwer fixed point theorem, we prove that if the periodic system is permanent, then there is at least one positive periodic solution of the system. We show that the conditions for global attractivity of the positive semi-trivial periodic solution and permanence of the population of the model depend on time delay, so, we call it \u201cprofitless\u201d. In this paper, the main feature is that we introduce multi-delays and impulses into the predator\u2013prey model, exhibit a new modeling method which is applied to investigate multi-species impulsive multi-delays differential equations.",
        "keywords": [
            "permanence",
            "delay differential equation",
            "fixed point theorem"
        ],
        "authors": [
            {
                "name": "Xinzhu Meng",
                "org": "Shandong University of Science and Technology(Shandong University of Science and Technology,Shandong Univ. of Sci. and Technol.),Qingdao,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Academia Sinica, Beijing 100080, PR China"
            },
            {
                "name": "Qing-xue Li",
                "org": "Foreign Languages College, Shandong University of Science and Technology, Qingdao 266510, PR China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2008
    },
    "VHpvDk9K": {
        "id": "VHpvDk9K",
        "title": "Nonlinear modelling and qualitative analysis of a real chemostat with pulse feeding",
        "abstract": "The control of substrate concentration in the bioreactor medium should be due to the substrate inhibition phenomenon. Moreover, the oxygen demand in a bioreactor should be lower than the dissolved oxygen content. The biomass concentration is one of the most important factors which affect the oxygen demand. In order to maintain the dissolved oxygen content in an appropriate range, the biomass concentration should not exceed a critical level. Based on the design ideas, a mathematical model of a chemostat with Monod-type kinetics and impulsive state feedback control for microorganisms of any biomass yield is proposed in this paper. By the existence criteria of periodic solution of a general planar impulsive autonomous system, the conditions for the existence of period-1 solution of the system are obtained. The results simplify the choice of suitable operating conditions for continuous culture systems. It also points out that the system is not chaotic according to the analysis on the existence of period-2 solution. The results and numerical simulations show that the chemostat system with state impulsive control tends to a stable state or a period solution. \u00a9 2010 Yuan Tian et al.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "KaiBiao Sun",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            },
            {
                "name": "Yuan Tian",
                "org": "Dalian University(Dalian University),Dalian,China"
            },
            {
                "name": "Andrzej Kasperski",
                "org": "Uniwersytet Zielonog\u00f3rski(University of Zielona G\u00f3ra,University of Zielona Gora),Zielona Gora,Poland"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            }
        ],
        "venue": "Discrete Dynamics in Nature and Society",
        "year": 2010
    },
    "T24eoo5a": {
        "id": "T24eoo5a",
        "title": "Effects of toxicants on a stage-structured population growth model",
        "abstract": "A stage-structured model of population growth in a polluted environment is proposed. The main purpose of this paper is to study the effect of stage structure on population growth in a polluted environment. Some sufficient conditions on permanence and extinction of the population have been obtained, and it is shown that the number of population changes periodically under appropriate assumption.",
        "keywords": [],
        "authors": [
            {
                "name": "Yanni Xiao",
                "org": "Institute of Mathematics, Academia Sinica, Beijing 100080, People's Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academia Sinica, Beijing 100080, People's Republic of China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2001
    },
    "1WKVM5Mn": {
        "id": "1WKVM5Mn",
        "title": "Global dynamics behaviors for a nonautonomous Lotka\u2013Volterra almost periodic dispersal system with delays",
        "abstract": "A nonautonomous Lotka\u2013Volterra dispersal system with continuous delays and discrete delays is considered. By using a comparison theorem and delay differential equation basic theory, we obtain sufficient conditions for the permanence of the population in every patch. By constructing a suitable Lyapunov functional, we prove that the system is globally asymptotically stable under some appropriate conditions. Using almost periodic functional hull theory, we get sufficient conditions for the existence, uniqueness and globally asymptotical stability for an almost periodic solution. This implies that the population in every patch exhibits stable almost periodic fluctuation. Furthermore, the results show that the permanence and global stability of system, and the existence and uniqueness of a positive almost periodic solution, depend on the delay; then we call it \u201cprofitless\u201d.",
        "keywords": [
            "global asymptotic stability",
            "hull",
            "almost periodic solution",
            "diffusion",
            "delays",
            "lyapunov function",
            "delay differential equation",
            "almost periodic function"
        ],
        "authors": [
            {
                "name": "Xinzhu Meng",
                "org": ""
            },
            {
                "name": "Jianjun Jiao",
                "org": "School of Mathematics and Statistics, Guizhou College of Finance and Economics, Guiyang 550004, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Academia Sinica, Beijing 100080, PR China"
            }
        ],
        "venue": "Nonlinear Analysis",
        "year": 2008
    },
    "VwmYwAmZ": {
        "id": "VwmYwAmZ",
        "title": "Some new results for a logistic almost periodic system with infinite delay and discrete delay",
        "abstract": "A nonautonomous logistic almost periodic system with infinite delay and discrete delay is considered. Our result shows that the system is globally asymptotically stable under the condition for the boundedness of the system. By using almost periodic functional Hull theory and new computational techniques, we show that the almost periodic system has a unique globally asymptotically stable strictly positive almost periodic solution under the condition for the boundedness of the system. Some recent results are improved, and an open question is answered.",
        "keywords": [
            "permanence",
            "nonautonomous logistic system",
            "almost periodic solution",
            "infinite delays",
            "global asymptotical stability",
            "almost periodic function"
        ],
        "authors": [
            {
                "name": "Xinzhu Meng",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Academia Sinica, Beijing, 100080, PR China"
            },
            {
                "name": "Xuelei Wang",
                "org": "Information Science and Engineering College, Shandong Agricultural University, Taian 271018, PR China"
            }
        ],
        "venue": "Nonlinear Analysis: Real World Applications",
        "year": 2009
    },
    "tNqV25QU": {
        "id": "tNqV25QU",
        "title": "Dynamics of the genic mutational rate on a population system with birth pulse and impulsive input toxins in polluted environment",
        "abstract": "In this paper, we consider the genic mutation on an impulsive population system in polluted environment. All solutions of the investigated system are proved to be uniformly bounded. Using mathematical analysis methods, the conditions of the globally asymptotically stable population-extinction solution of the investigated system are obtained. The permanent condition of the investigated system is also obtained. Finally, numerical analysis is carried out illustrate our results. Our results provide reliable tactic basis for the practical biological resource management in polluted environment. \u00a9 2012 Korean Society for Computational and Applied Mathematics.",
        "keywords": [
            "birth pulse",
            "extinction",
            "genic mutation",
            "permanence",
            "polluted environment",
            "population system"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": "Guizhou University(Guizhou University),Guiyang,China"
            },
            {
                "name": "Shaohong Cai",
                "org": "Guizhou University(Guizhou University),Guiyang,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and System Sciences Chinese Academy of Sciences(Chinese Academy of Sciences,Academy of Mathematics and Systems Science),Beijing,China"
            }
        ],
        "venue": "Journal of Applied Mathematics and Computing",
        "year": 2012
    },
    "Z6tyJ4el": {
        "id": "Z6tyJ4el",
        "title": "A delayed stage-structured predator\u2013prey model with impulsive stocking on prey and continuous harvesting on predator",
        "abstract": "In this work, we investigate a delayed stage-structured Holling II predator\u2013prey model with impulsive stocking on prey and continuous harvesting on predator. Sufficient conditions of the global attractivity of predator-extinction periodic solution and the permanence of the system are obtained. These results show that the behavior of impulsive stocking on prey plays an important role for the permanence of the system. We also prove that all solutions of the system are uniformly ultimately bounded. Our results provide reliable tactical basis for the biological resource management.",
        "keywords": [
            "global attractivity",
            "permanence",
            "stage-structured",
            "impulsive",
            "resource manager"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": ""
            },
            {
                "name": "Guoping Pang",
                "org": "Department of Mathematics and Computer Sciences, Yulin Normal University, Yulin 537000, People\u2019s Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, People\u2019s Republic of China"
            },
            {
                "name": "Guilie Luo",
                "org": "School of Mathematical Sciences, Guangxi Normal University, Guilin 541004, People\u2019s Republic of China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2008
    },
    "2XHRtaHS": {
        "id": "2XHRtaHS",
        "title": "Nonlinear modelling of chemostat model with time delay and impulsive effect",
        "abstract": "In this paper, a chemostat model with periodically pulsed input and time delay is considered. We show that there exists a\n microorganism-free periodic solution, which is globally attractive when the period of impulsive effect is less than some critical\n value. Further, we give the sufficient conditions for the permanence of the model with time delay and pulsed input. We show\n that time delay, impulsive input can bring different effects on the dynamic behavior of the model by numerical analysis. We\n show that impulsive effect destroys the equilibria of the unforced continuous system and initiates periodic solution. Our\n results can be applied to culture the microorganism.",
        "keywords": [
            "Chemostat model",
            "Time delay",
            "Global attractivity",
            "Permanence"
        ],
        "authors": [
            {
                "name": "Zhong Zhao",
                "org": "Department of Mathematics, Huanghuai University, Zhumadian, 463000 Henan PR China"
            },
            {
                "name": "Xiuquan Zhang",
                "org": "Department of Mathematics, Huanghuai University, Zhumadian, 463000 Henan PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian, 116024 PR China"
            }
        ],
        "venue": "Nonlinear Dynamics",
        "year": 2011
    },
    "SjGys8tm": {
        "id": "SjGys8tm",
        "title": "Dynamic analysis of a Holling I predator-prey system with mutual interference concerning pest control",
        "abstract": "A Holling I predator-prey model with mutual interference concerning pest control is proposed and analyzed. The prey and predator are considered to be a pest and a natural enemy, respectively. The model is forced by the addition of periodic impulsive terms representing predator import (biological control) and pesticide application (chemical control) at different fixed moments. By using Floquet theory and small amplitude perturbations, we show the existence and stability of pest-free periodic solutions. Further, we prove that when the stability of pest-free periodic solutions is lost, the system is permanent by using analytic methods of differential equation theory. Numerical solutions are also given, which show that when stability of pest-free periodic solutions is lost, more exotic behavior can occur, such as quasi-periodic oscillation or chaos. We investigate the effect of impulsive perturbations on the unforced continuous system, and find that the forced system has a different dynamical behavior with a different range of initial values which are inside or outside the unstable limit cycle of the unforced continuous system. Finally, we compare the validity of the combination of biological control and chemical control with classical methods and conclude that the synthetical strategy is more effective than classical methods if we take effective chemical control. \u00a9 World Scientific Publishing Company.",
        "keywords": [
            "bifurcation",
            "mutual interference",
            "permanence",
            "pest control"
        ],
        "authors": [
            {
                "name": "Yujuan Zhang",
                "org": "Anshan Normal University(Anshan Normal University,Anshan Normal College),Anshan,China"
            },
            {
                "name": "Zhilong Xu",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            },
            {
                "name": "Bing Liu",
                "org": "Anshan Normal University(Anshan Normal University,Anshan Normal College),Anshan,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and System Sciences Chinese Academy of Sciences(Chinese Academy of Sciences,Academy of Mathematics and Systems Science),Beijing,China"
            }
        ],
        "venue": "Journal of Biological Systems",
        "year": 2005
    },
    "d4NQBsv0": {
        "id": "d4NQBsv0",
        "title": "Theoretical approach to modelling and analysis of the bioprocess with product inhibition and impulse effect.",
        "abstract": "This work presents the first mathematical model of a bioprocess with product inhibition and impulse effect. To begin with, an exemplary mathematical bioprocess model with product inhibition and impulse effect is formulated. Then, according to the model, the analysis of bioprocess stability is presented. The article expresses the product oscillation period, which provides the precise feeding time frame for the regulator bioprocess to achieve an equivalent stable output as that of a bioprocess with impulse effect in the same production environment. Moreover, in this work, the optimization of the production process with respect to the tunable parameters is investigated, and analytical expressions of their optimal values are provided. Numerical simulations using biological data are presented to illustrate the main results.",
        "keywords": [
            "periodic solution",
            "product inhibition",
            "optimization",
            "stability",
            "bioprocess with impulse effect"
        ],
        "authors": [
            {
                "name": "Yuan Tian",
                "org": "School of Mathematical Science, Dalian University of Technology, Dalian 116024, People\u2019s Republic of China"
            },
            {
                "name": "Andrzej Kasperski",
                "org": ""
            },
            {
                "name": "Kaibiao Sun",
                "org": "School of Control Science and Engineering, Dalian University of Technology, Dalian 116024, People\u2019s Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "School of Mathematical Science, Dalian University of Technology, Dalian 116024, People\u2019s Republic of China"
            }
        ],
        "venue": "BioSystems",
        "year": 2011
    },
    "nfuLdkIA": {
        "id": "nfuLdkIA",
        "title": "Dynamic Complexity of an Ivlev-Type Prey-Predator System with Impulsive State Feedback Control.",
        "abstract": "The dynamic complexities of an Ivlev-type prey-predator system with impulsive state feedback control are studied analytically and numerically. Using the analogue of the Poincar\u00e9 criterion, sufficient conditions for the existence and the stability of semitrivial periodic solutions can be obtained. Furthermore, the bifurcation diagrams and phase diagrams are investigated by means of numerical simulations, which illustrate the feasibility of the main results presented here. \u00a9 2012 Chuanjun Dai et al.",
        "keywords": [],
        "authors": [
            {
                "name": "Chuanjun Dai",
                "org": ""
            },
            {
                "name": "Min Zhao",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "J. Applied Mathematics",
        "year": 2012
    },
    "xKUeviQZ": {
        "id": "xKUeviQZ",
        "title": "Bifurcation and chaos of biochemical reaction model with impulsive perturbations",
        "abstract": "In this paper, a biochemical model with the impulsive perturbations is considered. By using the Floquet theorem for the impulsive equation and small-amplitude perturbation skills, we see that the boundary-periodic solution (x\u0303(t),0) is locally stable if some conditions are satisfied. In a certain limiting case, it is shown that a nontrivial periodic solution emerges via a supercritical bifurcation. By numerical simulation, we can show that the system presents rich dynamics, including periodic solutions, quasi-periodic oscillations, period doubling cascades, periodic halving cascades, symmetry bifurcations, and chaos. \u00a9 2010 Springer Science+Business Media B.V.",
        "keywords": [
            "bifurcation",
            "chaos",
            "nontrivial periodic solutions",
            "stability",
            "strange attractor",
            "numerical simulation",
            "satisfiability"
        ],
        "authors": [
            {
                "name": "Zhong Zhao",
                "org": "Huanghuai University(Huanghuai University),Zhumadian,China"
            },
            {
                "name": "Li Yang",
                "org": "Huanghuai University(Huanghuai University),Zhumadian,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            }
        ],
        "venue": "Nonlinear Dynamics",
        "year": 2011
    },
    "7fVwfYvl": {
        "id": "7fVwfYvl",
        "title": "Impulsive diffusion in single species model",
        "abstract": "In most population models, diffusion between patches is assumed to be continuous or discrete, but in practice many species diffuse only during a single period. In this paper we propose a single species model with impulsive diffusion between two patches, which provides a more natural description of population dynamics. By using the discrete dynamical system generated by a monotone, concave map for the population and a \u03f5 1 \u2212 \u03f5 2 variation we prove that the map always has a globally stable positive fixed point. This means that a single species system with impulsive diffusion always has a globally stable positive periodic solution. This result is further substantiated by numerical simulation.",
        "keywords": [
            "population dynamic",
            "numerical simulation",
            "population model",
            "fixed point"
        ],
        "authors": [
            {
                "name": "Limin Wang",
                "org": ""
            },
            {
                "name": "Zhijun Liu",
                "org": "Department of Mathematics, Hubei Institute for Nationalities, 445000 Enshi Hubei, PR China"
            },
            {
                "name": "Jinghui",
                "org": "Department of Mathematics, East China Normal University, 200062 Shanghai, China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, 116024 Dalian Liaoning, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2007
    },
    "vKNOddP8": {
        "id": "vKNOddP8",
        "title": "Periodic solution of a chemostat model with Monod growth rate and impulsive state feedback control.",
        "abstract": "In this paper, we develop a mathematical model concerning a chemostat with impulsive state feedback control to investigate the periodicity of bioprocess. By the existence criteria of periodic solution of a general planar impulsive autonomous system, the conditions under which the model has a periodic solution of order one are obtained. Furthermore, we estimate the position of the periodic solution of order one and discuss the existence of periodic solution of order two. The theoretical results and numerical simulations indicate that the chemostat system with impulsive state feedback control either tends to a stable state or has a periodic solution, which depends on the feedback state, the control parameter of the dilution rate and the initial concentrations of microorganisms and substrate.",
        "keywords": [
            "continuous culture",
            "microorganism",
            "impulsive control",
            "periodic solution of order one",
            "impulsive autonomous system"
        ],
        "authors": [
            {
                "name": "Hongjian Guo",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Journal of theoretical biology",
        "year": 2009
    },
    "B7cEJeMe": {
        "id": "B7cEJeMe",
        "title": "The Global Dynamic Behavior of the Competition Model of Three Species",
        "abstract": "In this paper, we decompose the dynamic behavior of the competitive Lotka\u2013Volterra (LV) model \u1e8b i = x i (1 \u2212 x i \u2212 \u03b1 i x i + 1 \u2212 \u03b2 i x i + 2 ), x i (0) > 0, \u03b1 i > 0, \u03b2 i > 0, i = 1, 2, 3, with x 4 = x 1 , x 5 = x 2 , into the dynamic behavior of two two-dimensional manifolds, and completely analyse the global asymptotic behavior of the competitive LV model. We obtain the necessary and sufficient conditions for the equilibrium of the competitive LV model to be positive and globally asymptotically stable in Int R 3 + , the necessary and sufficient conditions for the model having a family of limit cycle solutions and a heteroclinic cycle, both of which are the \u03c9-limit set of some other trajectories of the competitive LV model. Keywords extinction dominant local coordinate chart diffeomorphism References REFERENCES 1 R.M. May W.J. Leonard Nonlinear aspects of competition between three species SIAM J. Appl. Math. 29 1975 243 253 2 L.-S. Chen Mathematical Models and Methods in Ecology 1988 Science Press Beijing 3 L.-S. Chen J. Chen Nonlinear Biological Dynamic Systems 1993 Science Press Beijing 4 P. Schuster K. Sigmund R. Wolf On \u03c9-limit for competition between three species SIAM J. Appl. Math. 37 1979 49 54 5 X.-a. Zhang Z.-j. Liang The spatial periodic solution of LV model Chinese Sci. Bull. 40 1995 1934 1937 6 C.-w. Chi S. Hsu L.-h. Wu On the asymmetric May\u2013Leonard model of three competing species SIAM J. Appl. Math. 58 1998 211 226 7 T. Uno K. Odani On a Lotka\u2013Volterra model which can be projected to a sphere Nonlinear Anal. Theory Methods Appl. 30 1997 1405 1410 8 J. Coste J. Peiraud P. Coullet Asymptotic behavior in the dynamics competing species SIAM J. Appl. Math. 36 1979 516 543 9 Y.-q. Ye Theory of Limit Cycles Translations of Mathematical Monographs 66 1986 American Math. Society Providence 10 E.A. Gonzeles Generic properties of polynomial vector fields at infinity Trans. Amer. Math. Soc. 143 1969 201 222 11 X.-a. Zhang Z. Liang The geometric properties of homogeneous polynomial vector fields Z.-q. Deng Z.-j. Liang G. Lu S.-g. Ruan Differential Equations and Control Theory Lecture Notes in Pure and Applied Math. 176 1996 Dekker New York 12 P. Hartman Ordinary Differential Equations 1964 Wiley New York 13 E.A. Coddington N. Levinson Theory of Ordinary Differential Equations 1955 McGraw\u2013Hill New York 14 M.W. Hirsch Systems of differential equations which are competitive and cooperative. I. Limit sets SIAM J. Math. Anal. 13 1982 167 179 15 H. Smith Periodic Orbits of competitive and cooperative systems J. Differential Equations 65 1986 361 373",
        "keywords": [
            "extinction",
            "dominant",
            "local coordinate chart",
            "diffeomorphism",
            "limit cycle",
            "limit set",
            "heteroclinic cycle"
        ],
        "authors": [
            {
                "name": "Xin-an Zhang",
                "org": "Institute of Mathematics, Academia Sinica, Beijing, 100080, People's Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academia Sinica, Beijing, 100080, People's Republic of China"
            }
        ],
        "venue": "Journal of Mathematical Analysis and Applications",
        "year": 2000
    },
    "Vq1b3rMg": {
        "id": "Vq1b3rMg",
        "title": "Erratum to: The effect of pulsed harvesting policy on\u00a0the\u00a0inshore\u2013offshore fishery model with the impulsive diffusion",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Zhong Zhao",
                "org": "Department of Mathematics, Huanghuai University, Zhumadian, Henan 463000, P.R. China"
            },
            {
                "name": "Xiuquan Zhang",
                "org": "Department of Mathematics, Huanghuai University, Zhumadian, Henan 463000, P.R. China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian, 116024 P.R. China"
            }
        ],
        "venue": "Nonlinear Dynamics",
        "year": 2011
    },
    "RlLoOyW7": {
        "id": "RlLoOyW7",
        "title": "Analysis of a delayed epidemic model with pulse vaccination and saturation incidence.",
        "abstract": "Pulse vaccination is an important strategy for the elimination of infectious diseases. An SEIRS epidemic model with time delays and pulse vaccination is formulated in this paper. Using the discrete dynamical system determined by the stroboscopic map, we obtain the exact infection-free periodic solution of the impulsive epidemic system and prove that the infection-free periodic solution is globally attractive if the vaccination rate is larger than theta*. Moreover, we show that the disease is uniformly persistent if the vaccination rate is less than theta*. The permanence of the model is investigated analytically. Our results indicate that a long latent period of the disease is sufficient condition for the extinction of the disease.",
        "keywords": [
            "time delay",
            "permanence",
            "seirs epidemic model",
            "pulse vaccination",
            "global attractivity",
            "infectious disease",
            "epidemic model"
        ],
        "authors": [
            {
                "name": "Shujing Gao",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, PR China"
            },
            {
                "name": "Juan J Nieto",
                "org": "Departamento de An\u00e1lisis Matem\u00e1tico, Facultad de Matem\u00e1ticas, Universidad de Santiago de Compostela 15782, Spain"
            },
            {
                "name": "Angela Torres",
                "org": "Departamento de Psiquiatr\u00eda, Radiolog\u00eda y Salud P\u00fablica, Facultad de Medicina, Universidad de Santiago de Compostela 15782, Spain"
            }
        ],
        "venue": "Vaccine",
        "year": 2006
    },
    "HwfNhlni": {
        "id": "HwfNhlni",
        "title": "Bifurcation of nontrivial periodic solutions for an impulsively controlled pest management model",
        "abstract": "This paper investigates the onset of nontrivial periodic solutions for an integrated pest management model which is subject to pulsed biological and chemical controls. The biological control consists in the periodic release of infective individuals, while the chemical control consists in periodic pesticide spraying. It is assumed that both controls are used with the same periodicity, although not simultaneously. To model the spread of the disease which is propagated through the release of infective individuals, an unspecified force of infection is employed. The problem of finding nontrivial periodic solutions is reduced to showing the existence of nontrivial fixed points for the associated stroboscopic mapping of time snapshot equal to the common period of controls. The latter problem is in turn treated via a projection method. It is then shown that once a threshold condition is reached, a stable nontrivial periodic solution emerges via a supercritical bifurcation.",
        "keywords": [
            "nontrivial periodic solutions bifurcation impulsive controls nonlinear force of infection fixed point argument",
            "nonlinear force of infection",
            "fixed point argument",
            "bifurcation",
            "nontrivial periodic solutions",
            "impulsive controls",
            "projection method",
            "integrated pest management",
            "fixed point",
            "pest management"
        ],
        "authors": [
            {
                "name": "Paul Georgescu",
                "org": ""
            },
            {
                "name": "Hong Zhang",
                "org": "Department of Mathematics, Jiangsu University, ZhenJiang, JiangSu 212013, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Science, Academia Sinica, Beijing 100080, PR China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2008
    },
    "PSkVwJOB": {
        "id": "PSkVwJOB",
        "title": "The stage-structured predator\u2013prey model and optimal harvesting policy",
        "abstract": "In this paper, we establish a mathematical model of two species with stage structure and the relation of predator\u2013prey, to obtain the necessary and sufficient condition for the permanence of two species and the extinction of one species or two species. We also obtain the optimal harvesting policy and the threshold of the harvesting for sustainable development.",
        "keywords": [
            "permanence",
            "extinction",
            "threshold of the harvesting",
            "92d25",
            "34c05",
            "maximum sustainable yield",
            "mathematical model",
            "sustainable development"
        ],
        "authors": [
            {
                "name": "Xin-an Zhang",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academia Sinica, Beijing 100080, People's Republic of China"
            },
            {
                "name": "Avidan U Neumann",
                "org": "Faculty of Life Sciences, Bar-Ilan University, Ranat-Gan 52900, Israel"
            }
        ],
        "venue": "Mathematical Biosciences",
        "year": 2000
    },
    "lgPpMIfi": {
        "id": "lgPpMIfi",
        "title": "Periodic solution of a class of epidemic models",
        "abstract": "This paper has completely studied the dynamical properties of a class of epidemiological models, obtained the necessary and sufficient condition for a unique periodic solution which is asymptotically orbitally stable, and the necessary and sufficient conditions for the global asymptotic stability of the positive equilibrium.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Xinan Zhang",
                "org": "Huazhong Normal University(Central China Normal University,Huazhong Normal University),Wuhan,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            }
        ],
        "venue": "Computers and Mathematics with Applications",
        "year": 1999
    },
    "JhVcbRA0": {
        "id": "JhVcbRA0",
        "title": "Permanence and periodicity of a delayed ratio-dependent predator-prey model with Holling type functional response and stage structure",
        "abstract": "A periodic and delayed ratio-dependent predator-prey system with Holling type III functional response and stage structure for both prey and predator is investigated. It is assumed that immature predator and mature individuals of each species are divided by a fixed age, and immature predator do not have the ability to attack prey. Sufficient conditions are derived for the permanence and existence of positive periodic solution of the model. Numerical simulations are presented to illustrate the feasibility of our main results.",
        "keywords": [
            "delayed ratio-dependent predator-prey model",
            "main result",
            "positive periodic solution",
            "fixed age",
            "delayed ratio-dependent predator-prey system",
            "mature individual",
            "immature predator",
            "numerical simulation",
            "iii functional response",
            "holling type",
            "stage structure",
            "functional response",
            "permanence"
        ],
        "authors": [
            {
                "name": "Zuxiong Li",
                "org": "School of Mathematical Sciences, Dalian University of Technology, Dalian 116024, People's Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "School of Mathematical Sciences, Dalian University of Technology, Dalian 116024, People's Republic of China"
            },
            {
                "name": "Jianmin Huang",
                "org": "College of Computer Science and Information Technology, Guangxi Normal University, Guilin 541004, People's Republic of China"
            }
        ],
        "venue": "J. Computational Applied Mathematics",
        "year": 2009
    },
    "clYLfujI": {
        "id": "clYLfujI",
        "title": "Analysis of an SI epidemic model with nonlinear transmission and stage structure",
        "abstract": "A disease transmission model of SI type with stage structure is formulated. The stability of disease free equilibrium, the existence and uniqueness of an endemic equilibrium, the existence of a global attractor are investigated.",
        "keywords": [
            "Disease free equilibrium",
            "Endemic equilibrium",
            "Global attractor",
            "SI epidemic model",
            "Threshold"
        ],
        "authors": [
            {
                "name": "Lu Zhonghua",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "Gao Shujing",
                "org": "Guangzhou University(Guangzhou University ^),Guangzhou,China"
            },
            {
                "name": "Chen Lansun",
                "org": "Academy of Mathematics and System Sciences Chinese Academy of Sciences(Chinese Academy of Sciences,Academy of Mathematics and Systems Science),Beijing,China"
            }
        ],
        "venue": "Acta Mathematica Scientia",
        "year": 2003
    },
    "IeVRUfan": {
        "id": "IeVRUfan",
        "title": "Harmless delays and global attractivity for nonautonomous predator-prey system with dispersion",
        "abstract": "In this paper, we consider a nonautonomous predator-prey model with dispersion and a finite number of discrete delays. The system consists of two Lotka-Volterra patches and has two species: one can disperse between two patches, but the other is confined to one patch and cannot disperse. Our purpose is to demonstrate that the time delays are harmless for uniform persistence of the solutions of the system. Furthermore, we establish conditions under which the system admits a positive periodic solution which attracts all solutions.",
        "keywords": [
            "global attractivity",
            "harmless delays",
            "dispersion"
        ],
        "authors": [
            {
                "name": "Xinyu Song",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Computers and Mathematics with Applications",
        "year": 2000
    },
    "aD4mx985": {
        "id": "aD4mx985",
        "title": "Analysis of a Delayed Chemostat Model with Impulsive Perturbation on the Polluted Nutrient",
        "abstract": "In this paper,a delayed chemostat model with impulsive input the polluted nutrient is considered.Using the discrete dynamical system determined by the stroboscopic map,we obtain a microorganism-extinction periodic solution.Further,it is globally attractive.The permanent condition of the investigated system is also obtained by the theory of impulsive delay differential equation.Our results reveal that the delayed response in growth plays an important role on the outcome of the chemostat.",
        "keywords": [
            "Permanence",
            "Extinction",
            "Chemostat model",
            "Delayed response in growth",
            "Impulsive perturbation"
        ],
        "authors": [
            {
                "name": "JIAO Jianjun",
                "org": "School of Mathematics and Statistics,Guizhou Key Laboratory of Economic System Simulation,Guizhou College of Finance & Economics,Guiyang ,China"
            },
            {
                "name": "CHEN Lansun",
                "org": "Institute of Mathematics,Academia Sinica,Beijing ,China"
            }
        ],
        "venue": "Mathematica Applicata",
        "year": 2010
    },
    "u0sdWdQW": {
        "id": "u0sdWdQW",
        "title": "Chaotic behavior of a chemostat model with Beddington\u2013DeAngelis functional response and periodically impulsive invasion",
        "abstract": "In the paper, we considered a predator\u2013prey model with Beddington\u2013DeAngelis functional response in periodic pulsed chemostat. We discussed the boundness of system and the stability of prey and predator-eradication periodic solution of system. Further, using numerical simulation method, we show that this impulsive system with periodically pulsed substrate display a series of complex phenomena, which include (1) period-doubling cascade, (2) period-halfing cascade, (3) chaos and (4) periodic window.",
        "keywords": [
            "functional response",
            "numerical simulation"
        ],
        "authors": [
            {
                "name": "Shuwen Zhang",
                "org": ""
            },
            {
                "name": "Dejun Tan",
                "org": "Department of Mathematics, Anshan Normal University, Anshan, Liaoning 114005, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2006
    },
    "rTXQdAzJ": {
        "id": "rTXQdAzJ",
        "title": "Periodic solutions of single-species nonautonomous diffusion models with continuous time delays",
        "abstract": "Single-species nonautonomous diffusion models with periodic coefficients and continuous time delays are investigated in this paper. In particular, we derive sufficient conditions that guarantee the existence of a positive periodic solution which is globally asymptotically stable.",
        "keywords": [
            "diffusion model"
        ],
        "authors": [
            {
                "name": "Jingru Zhang",
                "org": "Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "Chen Lansun",
                "org": "Institute of Mathematics, Academia Sinica Beijing 100080, P.R. China"
            }
        ],
        "venue": "Mathematical and Computer Modelling",
        "year": 1996
    },
    "tm557wEM": {
        "id": "tm557wEM",
        "title": "A ratio-dependent predator-prey model with disease in the prey",
        "abstract": "In this paper, a ratio-dependent predator-prey system with disease in the prey is formulated and analyzed. Mathematical analyses of the model equations with regard to invariance of nonnegativity, boundedness of solutions, nature of equilibria, permanence and global stability are analyzed. Specially, we shall show that ratio-dependent predator-prey models are rich in boundary dynamics, and most importantly, we shall show that a periodic solution can occur whether the system is permanent or not, that is, there are solutions which tend to disease-free equilibrium while bifurcating periodic solution exists.",
        "keywords": [],
        "authors": [
            {
                "name": "Yanni Xiao",
                "org": "Academy of Mathematics and System Sciences, Academia Sinica, Beijing 100080, P.R. China"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and System Sciences, Academia Sinica, Beijing 100080, P.R. China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2002
    },
    "UbEW6jln": {
        "id": "UbEW6jln",
        "title": "Uniform persistence and existence of strictly positive solutions in nonautonomous Lotka-Volterra competitive systems with delays",
        "abstract": "In this paper, we establish some new sufficient conditions for uniform persistence and existence of strictly positive solutions of the general nonautonomous N -species competitive Lotka-Volterra systems with delays. These results are different to those in [1\u20134].",
        "keywords": [
            "nonautonomous lotka-volterra system",
            "strictly positive solution",
            "uniform persistence",
            "delay",
            "competition",
            "liapunov functional"
        ],
        "authors": [
            {
                "name": "Zhidong Teng",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Computers and Mathematics with Applications",
        "year": 1999
    },
    "5PtNyy0q": {
        "id": "5PtNyy0q",
        "title": "TWO DIFFERENT VACCINATION STRATEGIES IN AN SIR EPIDEMIC MODEL WITH SATURATED INFECTIOUS FORCE",
        "abstract": "",
        "keywords": [
            "extinction",
            "impulse",
            "permanence",
            "treatment",
            "vaccination",
            "epidemic model"
        ],
        "authors": [
            {
                "name": "YONGZHEN PEI",
                "org": ""
            },
            {
                "name": "SHAOYING LIU",
                "org": ""
            },
            {
                "name": "LANSUN CHEN",
                "org": ""
            },
            {
                "name": "CHUNHUA WANG",
                "org": ""
            }
        ],
        "venue": "International Journal of Biomathematics",
        "year": 2008
    },
    "5zX7UcH5": {
        "id": "5zX7UcH5",
        "title": "Dynamic analysis of lactic acid fermentation with impulsive input",
        "abstract": "In this paper, a mathematical model for the lactic acid fermentation in membrane bioreactor is investigated. Using the Floquet\u2019s\n theorem and small amplitude perturbation method, we obtain the biomass-free periodic solution is locally stable if some conditions\n are satisfied. The permanent conditions of the system are also given. Furthermore, in a certain limiting case it is shown\n that a nontrivial periodic solution emerges via a supercritical bifurcation. Finally, our findings are confirmed by means\n of numerical simulations.",
        "keywords": [
            "Lactic acid fermentation",
            "Impulsive input",
            "Asymptotically stable",
            "Periodic solution",
            "Permanent",
            "Bifurcation"
        ],
        "authors": [
            {
                "name": "Zhong Zhao",
                "org": "Huanghuai University Department of Mathematics Zhumadian 463000 Henan People\u2019s Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116024 People\u2019s Republic of China"
            }
        ],
        "venue": "Journal of Mathematical Chemistry",
        "year": 2010
    },
    "E3iLpyIe": {
        "id": "E3iLpyIe",
        "title": "Dynamical analysis of a Lotka\u2013Volterra competition system with impulsively linear invasion",
        "abstract": "In this work, we consider a Lotka\u2013Volterra competition system with impulsive linear invasion between two patches. We prove all solutions of the investigated system are uniformly ultimately bounded. Some conditions are obtained to guarantee the population \\(x(t)\\)-extinction periodic solution is linearly stable, this indicates that the alien species invade successfully, and exclude the native species to extinct. The permanent conditions of the investigated system is also obtained, this indicates that the alien species invade successfully, and the alien species coexist with the native species. Numerical analysis are inserted to illustrate our results. By the numerical analysis, we find that there exists a threshold of invading unsuccessfully, which indicates that the alien species invade unsuccessfully, and the native species excludes the alien species to extinct. These results indicate that impulsive linear invasion plays an important role in dynamics of ecosystem. Our results provide reliable tactic basis for the biological resources management.",
        "keywords": [
            "Lotka\u2013Volterra competition system",
            " Impulsively linear invasion",
            " Extinction",
            " Permanence",
            " 34A37",
            " 92B05"
        ],
        "authors": [
            {
                "name": "jianjun jiao",
                "org": "guizhou university of finance and economics"
            },
            {
                "name": "shaohong cai",
                "org": "guizhou university of finance and economics"
            },
            {
                "name": "lansun chen",
                "org": "Institute of Mathematics,Academy of Mathematics and System Sciences,Beijing,People\u2019s Republic of China"
            }
        ],
        "venue": "Journal of Applied Mathematics and Computing",
        "year": 2014
    },
    "kJKZRLSS": {
        "id": "kJKZRLSS",
        "title": "The effect of impulsive spraying pesticide on stage-structured population models with birth pulse",
        "abstract": "In most models of population dynamics, increases in population due to birth are assumed to be time dependent, but many species reproduce only a single period of the year. In this paper, we construct a stage-structured pest model with birth pulse and periodic spraying pesticide at fixed time in each birth period by using impulsive differential equation. Using the discrete dynamical system determined by the stroboscopic map, we obtain an exact periodic solution of systems which are with Ricker function or Beverton-Holt function, and obtain the threshold conditions for their stability. Further, we show that the time of spraying pesticide has a strong impact on the number of the mature pest population. Our results imply that the best time of spraying pesticide is at the end of the season, that is before and near the time of birth. Finally, by numerical simulations we find that the dynamical behaviors of the stage-structured population models with birth pulse and impulsive spraying pesticide are very complex, including period-doubling cascade, period-halving cascade, chaotic bands with periodic windows and \"period-adding\" phenomena. \u00a9 World Scientific Publishing Company.",
        "keywords": [
            "bifurcation",
            "birth pulse",
            "impulsive spraying pesticide",
            "stage structure"
        ],
        "authors": [
            {
                "name": "Bing Liu",
                "org": "Anshan Normal University(Anshan Normal University,Anshan Normal College),Anshan,China"
            },
            {
                "name": "Zhidong Teng",
                "org": "Xinjiang University(Xinjiang University),Urumqi,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and System Sciences Chinese Academy of Sciences(Chinese Academy of Sciences,Academy of Mathematics and Systems Science),Beijing,China"
            }
        ],
        "venue": "Journal of Biological Systems",
        "year": 2005
    },
    "4KXLdLNT": {
        "id": "4KXLdLNT",
        "title": "Periodic solution of neutral Lotka\u2013Volterra system with periodic delays",
        "abstract": "A nonautonomous n -species Lotka\u2013Volterra system with neutral delays is investigated. A set of verifiable sufficient conditions is derived for the existence of at least one strictly positive periodic solution of this Lotka\u2013Volterra system by applying an existence theorem and some analysis techniques, where the assumptions of the existence theorem are different from that of Gaines and Mawhin's continuation theorem [R.E. Gaines, J.L. Mawhin, Coincidence Degree and Nonlinear Differential Equations, Springer-Verlag, Berlin, 1977] and that of abstract continuation theory for k -set contraction [W. Petryshyn, Z. Yu, Existence theorem for periodic solutions of higher order nonlinear periodic boundary value problems, Nonlinear Anal. 6 (1982) 943\u2013969]. Moreover, a problem proposed by Freedman and Wu [H.I. Freedman, J. Wu, Periodic solution of single species models with periodic delay, SIAM J. Math. Anal. 23 (1992) 689\u2013701] is answered.",
        "keywords": [
            "existence theorem",
            "lotka\u2013volterra system",
            "positive periodic solution",
            "neutral delay",
            "higher order",
            "differential equation",
            "mathematical analysis",
            "boundary value problem"
        ],
        "authors": [
            {
                "name": "Zhijun Liu",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, 116024 Dalian Liaoning, PR China"
            }
        ],
        "venue": "Journal of Mathematical Analysis and Applications",
        "year": 2006
    },
    "7Ix736SA": {
        "id": "7Ix736SA",
        "title": "The dynamics of an age structured predator\u2013prey model with disturbing pulse and time delays",
        "abstract": "Many of the existing predator\u2013prey models on stage structured populations are some ordinary differential equations (ODE) or models without a disturbing effect of human behavior. In reality, death of the juvenile during its immature stage and catching or poisoning for the prey or predator occur continuously. From this basic standpoint, we formulate a general and robust prey-dependent consumption predator\u2013prey model with periodic harvesting (catching or poisoning) for the prey and stage structure for the predator with constant maturation time delay (through-stage time delay) and perform a systematic mathematical and ecological study. We show that the conditions for global attractivity of the \u2018predator-extinction\u2019 (\u2018predator-eradication\u2019) periodic solution and permanence of the population of the model depend on time delay, so, we call it \u201cprofitless\u201d. We also show that constant maturation time delay and impulsive catching or poisoning for the prey can bring great effects on the dynamics of system by numerical analysis. In this paper, the main feature is that we introduce time delay and pulse into the predator\u2013prey (natural enemy\u2013pest) model with age structure, exhibit a new modeling method which is applied to investigate impulsive delay differential equations, and give some reasonable suggestions for pest management.",
        "keywords": [
            "global attractivity",
            "permanence",
            "maturation time delay",
            "predator\u2013prey model with age structure",
            "impulsive effect",
            "ordinary differential equation",
            "numerical analysis",
            "human behavior",
            "age structure",
            "pest management",
            "delay differential equation"
        ],
        "authors": [
            {
                "name": "Xinzhu Meng",
                "org": ""
            },
            {
                "name": "Jianjun Jiao",
                "org": "School of Mathematics and Statistics, Guizhou College of Finance and Economics, Guiyang 550004, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, PR China"
            }
        ],
        "venue": "Nonlinear Analysis: Real World Applications",
        "year": 2008
    },
    "g95ZdE2c": {
        "id": "g95ZdE2c",
        "title": "Dynamic analysis of a turbidostat model with the feedback control\u2606",
        "abstract": "",
        "keywords": [
            "impulsive state feedback control",
            "inhibition of the microorganism concentration",
            "order one periodic solution",
            "turbidostat",
            "mathematical model",
            "dynamic analysis",
            "feedback control"
        ],
        "authors": [
            {
                "name": "Zhong Zhao",
                "org": ""
            },
            {
                "name": "Tieying Wang",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2010
    },
    "8h79Qjab": {
        "id": "8h79Qjab",
        "title": "Analysis of Monod-Haldane Chemostat Model With Delayed Growth Response and Impulsive Input",
        "abstract": "A Monod-Haldane chemostat model with delayed growth response and impulsive input concentration of the nutrient was considered.The sufficient conditions for the global attractivity of microorganism-extinction periodic solution were obtained.Furthermore,using corresponding theories and methods of impulsive delayed diferential equation,it was proved that the system was permanent under appropriate conditions.The results showed that time delay was profitless.",
        "keywords": [
            "chemostat model",
            "extinction",
            "time delay for growth response",
            "impulsive input",
            "permanence"
        ],
        "authors": [
            {
                "name": "Wei Chunjin",
                "org": "School of Science,Jimei University,Xiamen ,China;Department of Applied Mathematics,Dalian University of Technology,Dalian ,China"
            },
            {
                "name": "Chen Lansun",
                "org": "Department of Applied Mathematics,Dalian University of Technology,Dalian ,China"
            }
        ],
        "venue": "Journal of Nanjing Normal University(Natural Science Edition)",
        "year": 2008
    },
    "H3Fb4P8f": {
        "id": "H3Fb4P8f",
        "title": "Nonlinear Modelling and Qualitative Analysis of a Real Chemostat with Pulse Feeding",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yuan tian",
                "org": ""
            },
            {
                "name": "kaibiao sun",
                "org": ""
            },
            {
                "name": "andrzej kasperski",
                "org": ""
            },
            {
                "name": "lansun chen",
                "org": ""
            }
        ],
        "venue": "Discrete Dynamics in Nature and Society",
        "year": 2010
    },
    "juyC3Wyv": {
        "id": "juyC3Wyv",
        "title": "Modelling and qualitative analysis of a predator-prey system with state-dependent impulsive effects.",
        "abstract": "In this work, according to integrated pest management principles, a class of predator-prey system with state-dependent impulsive effects is put forward. In this model, the control strategies by releasing natural enemies and spraying pesticide at different thresholds are considered. The sufficient conditions for the existence and stability of the semi-trivial periodic solution and the positive order-1 periodic solution are given by the Poincar\u00e9 map and the properties of the Lambert W function. In addition, to verify the feasibility of our main results, the numerical simulations are carried out. \u00a9 2011 IMACS.",
        "keywords": [
            "impulsive differential equations",
            "periodic solution",
            "predator-prey system",
            "stability",
            "state-dependent",
            "state dependent"
        ],
        "authors": [
            {
                "name": "Yuan Tian",
                "org": ""
            },
            {
                "name": "Kaibiao Sun",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Mathematics and Computers in Simulation",
        "year": 2011
    },
    "lvSTqrxt": {
        "id": "lvSTqrxt",
        "title": "Periodic solutions of an n-species Lotka-Volterra type food-chain model with time delays",
        "abstract": "An n-species periodic Lotka-Volterra type simple food-chain model with time delays is investigated. By using Gaines and Mawhin's continuation theorem of coincidence degree theory and by constructing suitable Lyapunov functionals, sufficient conditions are derived for the existence, uniqueness and global stability of positive periodic solutions of the model. Numerical simulations are presented to illustrate our main results.",
        "keywords": [
            "global stability",
            "coincidence degree theory",
            "sufficient condition",
            "suitable lyapunov functionals",
            "lyapunov functional",
            "n-species lotka-volterra type food-chain",
            "n-species periodic lotka-volterra type",
            "continuation theorem",
            "food chain",
            "periodic solution",
            "main result",
            "positive periodic solution",
            "delay",
            "simple food-chain model",
            "time delay",
            "numerical simulation",
            "lyapunov function"
        ],
        "authors": [
            {
                "name": "Rui Xu",
                "org": "Department of Mathematics, Shijiazhuang Mechanical Engineering College, Shijiazhuang 050003, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and System Science, Academia Sinica, Beijing, 100080, China"
            },
            {
                "name": "Feilong Hao",
                "org": "Department of Mathematics, Shijiazhuang Mechanical Engineering College, Shijiazhuang 050003, PR China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2005
    },
    "ltWWcvqo": {
        "id": "ltWWcvqo",
        "title": "Eco-epidemiology model with Beddington-DeAngelis functional response",
        "abstract": "A predator-prey model with Beddington-DeAngelis functional response for the predator and infectious disease in the prey is studied, which considers impulsive releases of infective pests and natural enemies. The sufficient conditions of globally asymptotic stability of susceptible pest-eradication periodic solution and the permanence of the system are obtained by using Floquet's theorem, small-amplitude perturbation skills and comparison theorem. The results indicate that the susceptible pest will die out if the impulsive release amount of infected pests p>p *, whereas the system is persistent. Therefore, appropriate parameters p, q, T should be chosen for the control of the susceptible pest, which provides a theoretical basis and data basis for the practical pest management.",
        "keywords": [
            "Global stability",
            "Impulsion",
            "Infected individual",
            "Uniform permanence"
        ],
        "authors": [
            {
                "name": "Chunjin Wei",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            },
            {
                "name": "Yuan Tian",
                "org": "Dalian University(Dalian University),Dalian,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            }
        ],
        "venue": "Dalian Ligong Daxue Xuebao/Journal of Dalian University of Technology",
        "year": 2010
    },
    "sMEOASmO": {
        "id": "sMEOASmO",
        "title": "The effect of delays on the permanence for Lotka-Volterra systems",
        "abstract": "In this note, two examples are given to show that delays can make two-species Lotka-Volterra cooperative systems possessing an unbounded solution. This result indicates that unlike the two-species prey-predator or competitive systems, delays in cooperative ones are not harmless in the sense of permanence. These examples also give a negative answer to a recent conjecture for general n -species Lotka-Volterra delay systems proposed in [1, p. 310].",
        "keywords": [
            "unbounded solutions",
            "discrete delay",
            "lotka-volterra systems"
        ],
        "authors": [
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academia Sinica Beijing 100080, P.R. China"
            },
            {
                "name": "Zhengyi Lu",
                "org": "Institute of Mathematics, Academia Sinica Beijing 100080, P.R. China"
            },
            {
                "name": "Wendi Wang",
                "org": ""
            }
        ],
        "venue": "Applied Mathematics Letters",
        "year": 1995
    },
    "RqwgfPlS": {
        "id": "RqwgfPlS",
        "title": "An SEIRS epidemic model with two delays and pulse vaccination.",
        "abstract": "Pulse vaccination is an effective and important strategy to eradicate an infectious disease. The authors investigate an SEIRS\n epidemic model with two delays and pulse vaccination. By using the discrete dynamical system determined by stroboscopic map,\n the authors obtain that the infectious population dies out if R\n \u0394 R\n \u0394 > 1. The results indicate that a short period of pulse vaccination or a large pulse vaccination rate is a sufficient condition\n to eradicate the disease.",
        "keywords": [
            "persistence",
            "delay",
            "pulse vaccination",
            "seirs epidemic model.",
            "global attractivity",
            "infectious disease",
            "epidemic model"
        ],
        "authors": [
            {
                "name": "Jianjun JIAO",
                "org": "Guizhou College of Finance & Economics School of Mathematics and Statistics Guiyang 550004 China"
            },
            {
                "name": "Lansun CHEN",
                "org": "Chinese Academy of Science Institute of Mathematics, Academy of Mathematics and System Science Beijing 100190 China"
            },
            {
                "name": "Shaohong CAI",
                "org": "Guizhou College of Finance & Economics Guiyang 550004 China"
            }
        ],
        "venue": "J. Systems Science & Complexity",
        "year": 2008
    },
    "lEw4vWLi": {
        "id": "lEw4vWLi",
        "title": "Chaos in functional response host\u2013parasitoid ecosystem models",
        "abstract": "Natural populations whose generations are non-overlapping can be modeled by difference equations that describe how the population evolves in discrete time-steps. In the 1970s ecological research detected chaos and other forms of complex dynamics in simple population dynamics models, initiating a new research tradition in ecology. However, the investigations of complex population dynamics have mainly concentrated on single populations and no higher-dimensional ecological systems. In this study, in order to simulate cyclic effects due to changes in parasitoid's behavior, Holling type II and III functional response functions are applied to host\u2013parasitoid models, respectively. For each model, the complexities include (1) chaotic bands with periodic windows, pitchfork and tangent bifurcations, and attractor crises, (2) non-unique dynamics, meaning that several attractors coexist, (3) intermittency, and (4) supertransients.",
        "keywords": [
            "difference equation",
            "complex dynamics",
            "ecosystem model",
            "discrete time",
            "functional response",
            "population dynamic",
            "natural population"
        ],
        "authors": [
            {
                "name": "Sanyi Tang",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academia Sinica, Beijing 100080, People's Republic of China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2002
    },
    "YMNyPhX6": {
        "id": "YMNyPhX6",
        "title": "Analysis of a predator-prey model with Holling II functional response concerning impulsive control strategy",
        "abstract": "According to biological and chemical control strategy for pest control, we investigate the dynamic behavior of a Holling II functional response predator-prey system concerning impulsive control strategy-periodic releasing natural enemies and spraying pesticide at different fixed times. By using Floquet theorem and small amplitude perturbation method, we prove that there exists a stable pest-eradication periodic solution when the impulsive period is less than some critical value. Further, the condition for the permanence of the system is also given. Numerical results show that the system we consider can take on various kinds of periodic fluctuations and several types of attractor coexistence and is dominated by periodic, quasiperiodic and chaotic solutions, which implies that the presence of pulses makes the dynamic behavior more complex. Finally, we conclude that our impulsive control strategy is more effective than the classical one if we take chemical control efficiently.",
        "keywords": [
            "holling ii functional response",
            "stable pest-eradication periodic solution",
            "chemical control strategy",
            "impulsive control strategy-periodic",
            "predator-prey model",
            "pest control",
            "impulsive control strategy",
            "dynamic behavior",
            "periodic fluctuation",
            "impulsive period",
            "predator-prey system",
            "chemical control",
            "fluctuations",
            "attractor",
            "functional response",
            "bifurcation",
            "extinction",
            "pulse",
            "strategy",
            "numerical analysis",
            "dynamics",
            "permanence",
            "critical value",
            "applied mathematics"
        ],
        "authors": [
            {
                "name": "Bing Liu",
                "org": "Department of Mathematics, Anshan Normal University, Anshan, Liaoning, PR China and College of Mathematics and System Sciences, Xinjiang University, Urumqi, Xinjiang, PR China"
            },
            {
                "name": "Zhidong Teng",
                "org": "College of Mathematics and System Sciences, Xinjiang University, Urumqi, Xinjiang, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Beijing, PR China"
            }
        ],
        "venue": "Journal of Computational and Applied Mathematics",
        "year": 2006
    },
    "pmHXUAcw": {
        "id": "pmHXUAcw",
        "title": "Modelling and optimization of a continuous stirred tank reactor with feedback control and pulse feeding",
        "abstract": "Abstract The work is a presentation of the use of a continuous stirred tank reactor with feedback control to maintain the biomass concentration in desired range. Through analysis of the model\u2019s nonlinear dynamics and numerical performance simulations, conditions are obtained for the existence of the system\u2019s positive period-1 solution. The analysis also indicates that the system is not chaotic. Based on the model\u2019s analysis, it is demonstrated that the selection of suitable operating conditions for the continuous stirred tank reactor can be simplified. This offers the possibility of establishing more general and systematic operations and control strategies that are based on the counteraction of the mechanisms which underlie the adverse effects of the bioreactor dynamics. Moreover, in the article the new objective function is introduced and the aspect of advanced optimization of the biomass productivity is presented.",
        "keywords": [
            "growth kinetics",
            "feedback control",
            "periodic solution",
            "continuous stirred tank reactor",
            "biomass yield"
        ],
        "authors": [
            {
                "name": "Kaibiao Sun",
                "org": "School of Electronic and Information Engineering, Dalian University of Technology, Dalian 116024, People\u2019s Republic of China"
            },
            {
                "name": "Andrzej Kasperski",
                "org": ""
            },
            {
                "name": "Yuan Tian",
                "org": "School of Information Engineering, Dalian University, Dalian 116622, People\u2019s Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "School of Mathematical Science, Dalian University of Technology, Dalian 116024, People\u2019s Republic of China"
            }
        ],
        "venue": "Chemical Engineering & Processing: Process Intensification",
        "year": 2011
    },
    "Rz6Ek186": {
        "id": "Rz6Ek186",
        "title": "Pulse vaccination strategy in a delayed SIR epidemic model with vertical transmission",
        "abstract": "Pulse vaccination is an important and effective strategy for the elimination of infectious diseases. In this paper, a delayed SIR epidemic model with pulse vaccination and vertical transmission is proposed. Using the discrete dynamical system determined by the stroboscopic map, we obtain the exact periodic infection-free solution of the impulsive epidemic system and prove that the infection-free periodic solution is globally attractive if R* < 1. Moreover, we obtain that the disease is uniformly persistent if R* > 1. Our results indicate that a large pulse vaccination rate is sufficient condition for the extinction of the disease.",
        "keywords": [
            "Delay",
            "Global attractivity",
            "Permanence",
            "Pulse vaccination",
            "Sir epidemic model",
            "Vertical transmission"
        ],
        "authors": [
            {
                "name": "Shujing Gao",
                "org": "GanNan Normal University(Gannan Normal University),Ganzhou,China"
            },
            {
                "name": "Dehui Xie",
                "org": "GanNan Normal University(Gannan Normal University),Ganzhou,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            }
        ],
        "venue": "Discrete and Continuous Dynamical Systems - Series B",
        "year": 2007
    },
    "jaVWXhpo": {
        "id": "jaVWXhpo",
        "title": "Homoclinic bifurcation of prey-predator model with impulsive state feedback control.",
        "abstract": "",
        "keywords": [
            "successor function",
            "homoclinic bifurcation"
        ],
        "authors": [
            {
                "name": "Chunjin Wei",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2014
    },
    "mhFLHN23": {
        "id": "mhFLHN23",
        "title": "GLOBAL ATTRACTIVITY OF A STAGE-STRUCTURE VARIABLE COEFFICIENTS PREDATOR-PREY SYSTEM WITH TIME DELAY AND IMPULSIVE PERTURBATIONS ON PREDATORS",
        "abstract": "",
        "keywords": [
            "global attractivity",
            "impulsive",
            "prey-extinction",
            "stage-structured",
            "time delay"
        ],
        "authors": [
            {
                "name": "JIANJUN JIAO",
                "org": ""
            },
            {
                "name": "LANSUN CHEN",
                "org": ""
            }
        ],
        "venue": "International Journal of Biomathematics",
        "year": 2008
    },
    "zT3XGqnh": {
        "id": "zT3XGqnh",
        "title": "Stability of Periodic Solution for a Discrete Leslie Predator-prey System",
        "abstract": "The paper discusses a class of discrete Leslie predator-prey system.The authors obtain the persistence of the system,assuming that the coefficients in the system are periodic and the existence of a periodic solution.Under some additional conditions,the periodic solution is globally stable.",
        "keywords": [
            "Persistence",
            "Globally stable",
            "Periodic solution",
            "Leslie predator-prey system"
        ],
        "authors": [
            {
                "name": "Liang Zhiqing",
                "org": "Academy of Mathematics and Systems Science,Chinese Academy of Sciences,Beijing "
            },
            {
                "name": "Chen Lansun",
                "org": "Academy of Mathematics and Systems Science,Chinese Academy of Sciences,Beijing "
            }
        ],
        "venue": "Acta Mathematica Scientia",
        "year": 2006
    },
    "eovdzJz3": {
        "id": "eovdzJz3",
        "title": "Complexity of an Ivlev's predator-prey Model with Pulse",
        "abstract": "",
        "keywords": [
            "complexity",
            "extinction",
            "impulsive effect",
            "permanence",
            "predator-prey system",
            "bifurcation diagram",
            "functional response",
            "numerical simulation"
        ],
        "authors": [
            {
                "name": "Guoping Pang",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Advances in Complex Systems",
        "year": 2007
    },
    "YublVfCZ": {
        "id": "YublVfCZ",
        "title": "Extinction and permanence in delayed stage-structure predator\u2013prey system with impulsive effects",
        "abstract": "Based on the classical stage-structured model and Lotka\u2013Volterra predator\u2013prey model, an impulsive delayed differential equation to model the process of periodically releasing natural enemies at fixed times for pest control is proposed and investigated. We show that the conditions for global attractivity of the \u2018pest-extinction\u2019 (\u2018prey-eradication\u2019) periodic solution and permanence of the population of the model depend on time delay. We also show that constant maturation time delay and impulsive releasing for the predator can bring great effects on the dynamics of system by numerical analysis. As a result, the pest maturation time delay is considered to establish a procedure to maintain the pests at an acceptably low level in the long term. In this paper, the main feature is that we introduce time delay and pulse into the predator\u2013prey (natural enemy-pest) model with age structure, exhibit a new modelling method which is applied to investigate impulsive delay differential equations, and give some reasonable suggestions for pest management.",
        "keywords": [
            "age structure",
            "pest control",
            "numerical analysis",
            "delay differential equation",
            "pest management"
        ],
        "authors": [
            {
                "name": "Guoping Pang",
                "org": ""
            },
            {
                "name": "Fengyan Wang",
                "org": "College of Science, Jimei University, Xiamen, Fujian 361021, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian, Liaoning 116024, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2009
    },
    "0PJ8mUqK": {
        "id": "0PJ8mUqK",
        "title": "Dynamic complexities in a seasonal prevention epidemic model with birth pulses",
        "abstract": "In most of population dynamics, increases in population due to birth are assumed to be time-dependent, but many species reproduce only during a single period of the year. In this paper, we propose an epidemic model with density-dependent birth pulses and seasonal prevention. Using the discrete dynamical system determined by stroboscopic map, we obtain the local or global stability, numerical simulation shows there is a characteristic sequence of bifurcations, leading to chaotic dynamics, which implies that the dynamical behaviors of the epidemic model with birth pulses and seasonal prevention are very complex, including small amplitude oscillations, large-amplitude multi-annual cycles and chaos. This suggests that birth pulse, in effect, provides a natural period or cyclicity that may lead a period-doubling route to chaos.",
        "keywords": [
            "numerical simulation",
            "seasonality",
            "annual cycle",
            "density dependence",
            "oscillations",
            "population dynamic",
            "epidemic model"
        ],
        "authors": [
            {
                "name": "Shujing Gao",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            },
            {
                "name": "Lihua Sun",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, PR China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2005
    },
    "AKsNd8oX": {
        "id": "AKsNd8oX",
        "title": "A stage-structured Holling mass defence predator\u2013prey model with impulsive perturbations on predators",
        "abstract": "In this work, we consider a stage-structured Holling mass defence predator\u2013prey model with time delay and impulsive transmitting on predators. Sufficient conditions which guarantee the global attractivity of pest-extinction periodic solution and permanence of the system are obtained. We also prove that all solutions of the system are uniformly ultimately bounded. Our results provide reliable tactic basis for the practical pest management.",
        "keywords": [
            "global attractivity",
            "permanence",
            "time delay",
            "stage-structured",
            "impulsive",
            "pest-extinction",
            "pest management"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": ""
            },
            {
                "name": "Xinzhu Meng",
                "org": "College of Science, Shandong University of Science and Technology, Qingdao 266510, People\u2019s Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, People\u2019s Republic of China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2007
    },
    "Xm1mMOpv": {
        "id": "Xm1mMOpv",
        "title": "Periodic solutions for a two-species nonautonomous competition system with diffusion and impulses",
        "abstract": "By re-estimating the upper bound of \u222b 0 \u03c9 e u i ( t ) d t ( i = 1, 2), we generalize a result about the existence of a positive periodic solution for a two-species nonautonomous patchy competition system with time delay. Based on that system, we consider the impulsive harvesting and stocking, and establish a two-species nonautonomous competition Lotka\u2013Volterra system with diffusion and impulsive effects. With the continuation theorem of coincidence degree theory, we obtain the existence of a positive periodic solution for such a system. At last, two examples are given to demonstrate our results. 1 Introduction One of the most interesting questions in mathematical biology concerns the existence of positive periodic solutions for population dynamical systems. For the continuous Lotka\u2013Volterra systems, such a problem has been investigated extensively, and many skills and techniques have been developed. The existence of positive periodic solutions for such systems can be obtained by Brouwer fixed point theorem [2] , by standard techniques of bifurcation theory [3] , or by theory of topological degree [1] . In fact, these methods have been widely applied to various L\u2013V systems [4\u20136] . However, in population dynamics, many evolutionary processes experience short-time rapid changes after undergoing relatively long smooth variation. For examples, the harvesting and stocking occur at fixed moments, and some species usually immigrate at the same time every year, etc. If we still thought of the population dynamical systems with these phenomena as continuous systems, it would be unreasonable or incorrect. We should establish systems with impulsive effects. Recently, theories for impulsive differential equations have been introduced into population dynamics [7\u201310,12,13] . To the authors knowledge, the population dynamical systems with diffusion and impulsive effects are seldom discussed. In this paper, we mainly study the following impulsive system: (1.1) x \u02d9 1 ( t ) = x 1 ( t ) ( r 1 ( t ) - a 1 ( t ) x 1 ( t ) - b 1 ( t ) y ( t ) ) + D 1 ( t ) ( x 2 ( t ) - x 1 ( t ) ) , x \u02d9 2 ( t ) = x 2 ( t ) ( r 2 ( t ) - a 2 ( t ) x 2 ( t ) ) + D 2 ( t ) ( x 1 ( t ) - x 2 ( t ) ) , y \u02d9 ( t ) = y ( t ) r 3 ( t ) - a 3 ( t ) x 1 ( t ) - b 3 ( t ) y ( t ) - \u03b2 ( t ) \u222b - \u03c4 0 K ( s ) y ( t + s ) d s , t \u2260 t k , \u0394 x 1 ( t k ) = c k x 1 ( t k ) , \u0394 x 2 ( t k ) = d k x 2 ( t k ) , \u0394 y ( t k ) = e k y ( t k ) , where r i ( t ), a i ( t ) ( i = 1, 2, 3), D i ( t ) ( i = 1, 2), b i ( t ) ( i = 1, 3), \u03b2 ( t ) are all positive periodic continuous functions with period \u03c9 > 0, \u03c4 is a nonnegative constant, K ( s ) is a continuous nonnegative function on [\u2212 \u03c4 , 0] such that \u222b - \u03c4 0 K ( s ) d s = 1 , and there exists a number q > 0 such that c k + q = c k , d k + q = d k , e k + q = e k , t k + q = t k + \u03c9 ( k \u2208 Z + ). From the viewpoint of biology, we assume 1 + c k , 1 + d k , 1 + e k are all positive. System (1.1) shows that species X can diffuse between patch 1 and 2, while species Y is restricted to patch 1, and in patch 1 species X competes with Y for space or food. Furthermore, species X in two patches and species Y are harvested and stocked periodically at fixed moments, which occur when 1 + c k , 1 + d k , 1 + e k are smaller than 1 or larger than 1. These human activities occur frequently and therefore the study of their effects on the population behaviors is of great practical value. This paper is arranged as follows. In the next section, Theorem 2.1 in [1] is generalized by re-estimating the upper bound of \u222b 0 \u03c9 e u i ( t ) d t ( i = 1, 2). And we introduce the continuation theorem of coincidence degree theory, which is used to prove the existence of a positive periodic solution of (1.1) . Moreover, some notations are introduced. In Section 3 , we study the existence of a positive periodic solution of (1.1) . At last, two examples are worked out. 2 Generalization We estimate the upper bound of \u222b 0 \u03c9 e u i ( t ) d t ( i = 1, 2) in a easier way, and Theorem 2.1 in [1] can be generalized. In fact, let v ( t ) = max{ u 1 ( t ), u 2 ( t )}. We know that v ( t ) is a \u03c9 -periodic continuous function and (1) If u 1 ( t ) > u 2 ( t ), or u 1 ( t ) = u 2 ( t ) but u \u02d9 1 ( t ) \u2a7e u \u02d9 2 ( t ) , then v ( t ) = u 1 ( t ) and u \u02d9 1 ( t ) \u2a7d \u03bb [ r 1 ( t ) - a 1 ( t ) e u 1 ( t ) ] \u2a7d \u03bb [ r 1 m - a 1 l e u 1 ( t ) ] . (2) If u 2 ( t ) > u 1 ( t ), or u 2 ( t ) = u 1 ( t ) but u \u02d9 2 ( t ) \u2a7e u \u02d9 1 ( t ) , then v ( t ) = u 2 ( t ) and u \u02d9 2 ( t ) \u2a7d \u03bb [ r 2 ( t ) - a 2 ( t ) e u 2 ( t ) ] \u2a7d \u03bb [ r 2 m - a 2 l e u 2 ( t ) ] . Consequently, (2.1) D + v ( t ) \u2a7d \u03bb [ r - a e v ( t ) ] , where r = max { r 1 m , r 2 m } , a = min { a 1 l , a 2 l } . Integrating (2.1) over [0, \u03c9 ], we have 0 \u2a7d \u03bb [ r \u03c9 - a \u222b 0 \u03c9 e v ( t ) d t ] , which implies that \u222b 0 \u03c9 e v ( t ) d t \u2a7d r \u03c9 a . Further, \u222b 0 \u03c9 e u i ( t ) d t \u2a7d r \u03c9 a ( i = 1 , 2 ) . Thus, we can replace ( H 5 ) of Theorem 2.1 in [1] with ( H 5 \u2032 ) : a r \u00af 3 > a 3 m r , and obtain Theorem\u00a02.1\u2032 If (H 3 ): r i (t) > D i (t) (i = 1, 2), (H 4 ): b 3 l ( r 1 - D 1 \u00af ) > b 1 m r \u00af 3 , and ( H 5 \u2032 ): a r \u00af 3 > a 3 m r , are satisfied, then system ( 1.1 ) in [ 1 ] has at least one \u03c9-periodic solution. In order to obtain the existence of positive \u03c9 -periodic solutions for (1.1) , we shall introduce the continuation theorem of coincidence degree theory [11] . Let X , Y be real Banach spaces, L : Dom L \u2282 X \u2192 Y be a Fredholm mapping of index zero, and P : X \u2192 X , Q : Y \u2192 Y be continuous projectors such that Im P = Ker L , Ker Q = Im L , so that X = Ker L \u2295 Ker P , Y = Im L \u2295 Im Q . Denote by L P the restriction of L to Dom L \u2229 Ker P and by K P : Im L \u2192 Dom L \u2229 Ker P the inverse to L P . Let J : Im Q \u2192 Ker L be an isomorphism of Im Q onto Ker L . Then the continuation theorem can be described as follows. Lemma\u00a02.1 Let \u03a9 \u2282 X be an open bounded set and let N : X \u2192 Y be a continuous operator which is L-compact on \u03a9 \u00af (i.e. QN : \u03a9 \u00af \u2192 Y and K P ( I - Q ) N : \u03a9 \u00af \u2192 Y are compact). Assume that (a) for each \u03bb \u2208 (0, 1), x \u2208 \u2202 \u03a9 \u2229 Dom L, Lx \u2260 \u03bbNx, (b) for each x \u2208 \u2202 \u03a9 \u2229 Dom L, QNx \u2260 0, and (c) deg{ JQN, \u03a9 \u2229 Ker L, 0 } \u2260 0. Then Lx = Nx has at least one solution in \u03a9 \u00af \u2229 Ker L . For convenience, we use the following notations in the rest parts of the paper. (1) PC ( R + , R ) = { \u03c6 ( t )\u2223 \u03c6 : R + \u2192 R , lim s \u2192 t \u03c6 ( s ) = \u03c6 ( t ) if t \u2260 t k , lim t \u2192 t k - \u03c6 ( t ) = \u03c6 ( t k ) , lim t \u2192 t k + \u03c6 ( t ) exists, k \u2208 Z + }, (2) PC \u2032( R + , R ) = { \u03c6 ( t )\u2223 \u03c6 : R + \u2192 R , \u03c6 \u2032( t ) \u2208 PC ( R + , R )}, (3) PC \u03c9 = { \u03c6 \u2208 PC ( R + , R )\u2223 \u03c6 ( t ) = \u03c6 ( t + \u03c9 )}, PC \u03c9 \u2032 = { \u03c6 \u2208 PC \u2032 ( R + , R ) | \u03c6 ( t ) = \u03c6 ( t + \u03c9 ) } , (4) For f \u2208 PC \u03c9 , denote f \u00af = 1 \u03c9 \u222b 0 \u03c9 f ( t ) d t , f l = min t \u2208[0, \u03c9 ] \u2223 f ( t )\u2223, f m = max t \u2208[0, \u03c9 ] \u2223 f ( t )\u2223. 3 Positive \u03c9 -periodic solutions In this section, we demonstrate the existence of a positive \u03c9 -periodic solution for (1.1) . We have Theorem\u00a03.1 If system ( 1.1 ) satisfies (1) r 1 ( t ) + \u2211 k = 1 q ln ( 1 + c k ) > D 1 ( t ) and r 2 ( t ) + \u2211 k = 1 q ln ( 1 + d k ) > D 2 ( t ) , (2) ( ( r 1 - D 1 \u00af ) \u03c9 + \u2211 k = 1 q ln ( 1 + c k ) ) b 3 l > b 1 m ( r \u00af 3 \u03c9 + \u2211 k = 1 q ln ( 1 + e k ) ) , and (3) a ( r \u00af 3 \u03c9 + \u2211 k = 1 q ln ( 1 + e k ) ) > a 3 m ( r \u03c9 + \u2211 k = 1 q ln ( 1 + B k ) ) , where r = max { r 1 m , r 2 m } , B k = max{ c k , d k } , a = min { a 1 l , a 2 l } , then system ( 1.1 ) has at least one positive \u03c9-periodic solution. Proof Let x 1 ( t ) = exp( u 1 ( t )), x 2 ( t ) = exp( u 2 ( t )), y ( t ) = exp( u 3 ( t )). We obtain (3.1) u \u02d9 1 ( t ) = r 1 ( t ) - D 1 ( t ) - a 1 ( t ) e u 1 ( t ) - b 1 ( t ) e u 3 ( t ) + D 1 ( t ) e u 2 ( t ) - u 1 ( t ) , u \u02d9 2 ( t ) = r 2 ( t ) - D 2 ( t ) - a 2 ( t ) e u 2 ( t ) + D 2 ( t ) e u 1 ( t ) - u 2 ( t ) , u \u02d9 3 ( t ) = r 3 ( t ) - a 3 ( t ) e u 1 ( t ) - b 3 ( t ) e u 3 ( t ) - \u03b2 ( t ) \u222b - \u03c4 0 K ( s ) e u 3 ( t + s ) d s , t \u2260 t k , \u0394 u 1 ( t k ) = ln ( 1 + c k ) , \u0394 u 2 ( t k ) = ln ( 1 + d k ) , \u0394 u 3 ( t k ) = ln ( 1 + e k ) . It is obvious that if system (3.1) has an \u03c9 -periodic solution ( u 1 \u2217 ( t ) , u 2 \u2217 ( t ) , u 3 \u2217 ( t ) ) T , then ( e u 1 \u2217 ( t ) , e u 2 \u2217 ( t ) , e u 3 \u2217 ( t ) ) T = ( x 1 \u2217 ( t ) , x 2 \u2217 ( t ) , y \u2217 ( t ) ) T is a positive \u03c9 -periodic solution of system (1.1) . So in the following we discuss the existence of \u03c9 -periodic solutions of system (3.1) . To apply Lemma 2.1 , we denote X = {( u 1 ( t ), u 2 ( t ), u 3 ( t )) T \u2223 u i ( t ) \u2208 PC \u03c9 , i = 1, 2, 3} and denote \u2016 ( u 1 ( t ) , u 2 ( t ) , u 3 ( t ) ) T \u2016 = \u2211 i = 1 3 sup t \u2208 [ 0 , \u03c9 ] | u i ( t ) | . Then ( X , \u2225 \u00b7 \u2225) is a real Banach space. Moreover, let Y = u 1 ( t ) u 2 ( t ) u 3 ( t ) , m 1 n 1 p 1 , \u2026 , m q n q p q u i ( t ) \u2208 PC \u03c9 ( i = 1 , 2 , 3 ) ; ( m k , n k , p k ) T = ( \u0394 U 1 ( t k ) \u0394 U 2 ( t k ) , \u0394 U 3 ( t k ) ) T , a constant vector, k = 1 , 2 , \u2026 , q ; U i ( t ) , a primitive function of u i ( t ) , i = 1 , 2 , 3 . Assume that y = [ y 1 ( t ), y 1 , \u2026 , y q ] \u2208 Y , where y 1 ( t ) = ( u 1 ( t ), u 2 ( t ), u 3 ( t )) T and y k = ( m k , n k , p k ) T ( k = 1, 2, \u2026 , q ), and define \u2016 y \u2016 = \u2211 i = 1 3 sup t \u2208 [ 0 , \u03c9 ] | u i ( t ) | + \u2211 k = 1 q \u2016 y k \u2016 . Then ( Y , \u2225 \u00b7 \u2225) is also a Banach space. Set L : Dom L \u2282 X \u2192 Y , L u 1 ( t ) u 2 ( t ) u 3 ( t ) = u \u02d9 1 ( t ) u \u02d9 2 ( t ) u \u02d9 3 ( t ) , \u0394 u 1 ( t 1 ) \u0394 u 2 ( t 1 ) \u0394 u 3 ( t 1 ) , \u2026 , \u0394 u 1 ( t q ) \u0394 u 2 ( t q ) \u0394 u 3 ( t q ) , where Dom L = { ( u 1 ( t ) , u 2 ( t ) , u 3 ( t ) ) T \u2208 X | u \u02d9 i ( t ) \u2208 PC \u03c9 } = { ( u 1 ( t ) , u 2 ( t ) , u 3 ( t ) ) T \u2208 X | u i ( t ) \u2208 PC \u03c9 \u2032 ( i = 1 , 2 , 3 ) } . At the same time, we denote f 1 ( t ) = r 1 ( t ) - D 1 ( t ) - a 1 ( t ) e u 1 ( t ) - b 1 ( t ) e u 3 ( t ) + D 1 ( t ) e u 2 ( t ) - u 1 ( t ) , f 2 ( t ) = r 2 ( t ) - D 2 ( t ) - a 2 ( t ) e u 2 ( t ) + D 2 ( t ) e u 1 ( t ) - u 2 ( t ) , f 3 ( t ) = r 3 ( t ) - a 3 ( t ) e u 1 ( t ) - b 3 ( t ) e u 3 ( t ) - \u03b2 ( t ) \u222b - \u03c4 0 K ( s ) e u 3 ( t + s ) d s . Then we may define N : X \u2192 Y , N u 1 ( t ) u 2 ( t ) u 3 ( t ) = f 1 ( t ) f 2 ( t ) f 3 ( t ) ln ( 1 + c 1 ) ln ( 1 + d 1 ) ln ( 1 + e 1 ) , \u2026 , ln ( 1 + c q ) ln ( 1 + d q ) ln ( 1 + e q ) , and define two projectors P and Q as P : X \u2192 X , P u 1 u 2 u 3 = 1 \u03c9 \u222b 0 \u03c9 u 1 ( t ) d t \u222b 0 \u03c9 u 2 ( t ) d t \u222b 0 \u03c9 u 3 ( t ) d t . Q : Y \u2192 Y , Q u 1 ( t ) u 2 ( t ) u 3 ( t ) , m 1 n 1 p 1 , \u2026 , m q n q p q = 1 \u03c9 \u222b 0 \u03c9 u 1 ( t ) d t + \u2211 k = 1 q m k \u222b 0 \u03c9 u 2 ( t ) d t + \u2211 k = 1 q n k \u222b 0 \u03c9 u 3 ( t ) d t + \u2211 k = 1 q p k , 0 0 0 , \u2026 , 0 0 0 . Obviously, Ker L = R 3 , and Im L = u 1 ( t ) u 2 ( t ) u 3 ( t ) , m 1 n 1 p 1 , \u2026 , m q n q p q \u222b 0 \u03c9 u 1 ( t ) d t + \u2211 k = 1 q m k = 0 \u222b 0 \u03c9 u 2 ( t ) d t + \u2211 k = 1 q n k = 0 \u222b 0 \u03c9 u 3 ( t ) d t + \u2211 k = 1 q p k = 0 is closed in Y . Noting that Im P = Ker L , Ker Q = Im L and dimKer L = codimIm L = 3, we know that L is a Fredholm mapping of index zero. Moreover, by computation, the inverse K P of L P has the form K P : Im L \u2192 Ker P \u2229 Dom L , K P u 1 ( t ) u 2 ( t ) u 3 ( t ) , m 1 n 1 p 1 , \u2026 , m q n q p q = \u222b 0 t u 1 ( s ) d s + \u2211 t k < t m k - 1 \u03c9 \u222b 0 \u03c9 \u222b 0 t u 1 ( s ) d s d t - \u2211 k = 1 q m k + 1 \u03c9 \u2211 k = 1 q m k t k \u222b 0 t u 2 ( s ) d s + \u2211 t k < t n k - 1 \u03c9 \u222b 0 \u03c9 \u222b 0 t u 2 ( s ) d s d t - \u2211 k = 1 q n k + 1 \u03c9 \u2211 k = 1 q n k t k \u222b 0 t u 3 ( s ) d s + \u2211 t k < t p k - 1 \u03c9 \u222b 0 \u03c9 \u222b 0 t u 3 ( s ) d s d t - \u2211 k = 1 q p k + 1 \u03c9 \u2211 k = 1 q p k t k . Since QN u 1 ( t ) u 2 ( t ) u 3 ( t ) = 1 \u03c9 \u222b 0 \u03c9 f 1 ( t ) d t + \u2211 k = 1 q ln ( 1 + c k ) \u222b 0 \u03c9 f 2 ( t ) d t + \u2211 k = 1 q ln ( 1 + d k ) \u222b 0 \u03c9 f 3 ( t ) d t + \u2211 k = 1 q ln ( 1 + e k ) , 0 0 0 , \u2026 , 0 0 0 , and K p ( I \u2212 Q ) N : X \u2192 X , K p ( I - Q ) N u 1 ( t ) u 2 ( t ) u 3 ( t ) = \u222b 0 t f 1 ( s ) d s + \u2211 t k < t ln ( 1 + c k ) \u222b 0 t f 2 ( s ) d s + \u2211 t k < t ln ( 1 + d k ) \u222b 0 t f 3 ( s ) d s + \u2211 t k < t ln ( 1 + e k ) + 1 2 - t \u03c9 \u222b 0 \u03c9 f 1 ( s ) d s + \u2211 k = 1 q ln ( 1 + c k ) \u222b 0 \u03c9 f 2 ( s ) d s + \u2211 k = 1 q ln ( 1 + d k ) \u222b 0 \u03c9 f 3 ( s ) d s + \u2211 k = 1 q ln ( 1 + e k ) - 1 \u03c9 \u222b 0 \u03c9 \u222b 0 t f 1 ( s ) d s d t - \u2211 k = 1 q ln ( 1 + c k ) + 1 \u03c9 \u2211 k = 1 q ln ( 1 + c k ) t k 1 \u03c9 \u222b 0 \u03c9 \u222b 0 t f 2 ( s ) d s d t - \u2211 k = 1 q ln ( 1 + d k ) + 1 \u03c9 \u2211 k = 1 q ln ( 1 + d k ) t k 1 \u03c9 \u222b 0 \u03c9 \u222b 0 t f 3 ( s ) d s d t - \u2211 k = 1 q ln ( 1 + e k ) + 1 \u03c9 \u2211 k = 1 q ln ( 1 + e k ) t k , by the Lebesque convergence theorem, QN and K P ( I \u2212 Q ) N are continuous. Moreover, from the Arzela\u2013Ascoli theorem, QN ( \u03a9 \u00af ) , K P ( I - Q ) N ( \u03a9 \u00af ) are relatively compact for any open bounded set \u03a9 \u2282 X . Therefore N is L -compact on \u03a9 \u00af . In the following, the operator equation, Lx = \u03bbNx , \u03bb \u2208 (0, 1), is considered, which can be rewritten as: (3.2) u 1 \u02d9 ( t ) = \u03bb [ r 1 ( t ) - D 1 ( t ) - a 1 ( t ) e u 1 ( t ) - b 1 ( t ) e u 3 ( t ) + D 1 ( t ) e u 2 ( t ) - u 1 ( t ) ] , u 2 \u02d9 ( t ) = \u03bb [ r 2 ( t ) - D 2 ( t ) - a 2 ( t ) e u 2 ( t ) + D 2 ( t ) e u 1 ( t ) - u 2 ( t ) ] , u 3 \u02d9 ( t ) = \u03bb [ r 3 ( t ) - a 3 ( t ) e u 1 ( t ) - b 3 ( t ) e u 3 ( t ) - \u03b2 ( t ) \u222b - \u03c4 0 K ( s ) e u 3 ( t + s ) d s ] t \u2260 t k , \u0394 u 1 ( t k ) = \u03bb ln ( 1 + c k ) , \u0394 u 2 ( t k ) = \u03bb ln ( 1 + d k ) , \u0394 u 3 ( t k ) = \u03bb ln ( 1 + e k ) . Suppose ( u 1 ( t ), u 2 ( t ), u 3 ( t )) T \u2208 X is a solution of system (3.2) for some \u03bb \u2208 (0, 1). Integrating (3.2) over [0, \u03c9 ], it can be obtained that - \u2211 k = 1 q ln ( 1 + c k ) = \u222b 0 \u03c9 r 1 ( t ) - D 1 ( t ) - a 1 ( t ) e u 1 ( t ) - b 1 ( t ) e u 3 ( t ) + D 1 ( t ) e u 2 ( t ) - u 1 ( t ) d t , - \u2211 k = 1 q ln ( 1 + d k ) = \u222b 0 \u03c9 r 2 ( t ) - D 2 ( t ) - a 2 ( t ) e u 2 ( t ) + D 2 ( t ) e u 1 ( t ) - u 2 ( t ) d t , - \u2211 k = 1 q ln ( 1 + e k ) = \u222b 0 \u03c9 r 3 ( t ) - a 3 ( t ) e u 1 ( t ) - b 3 ( t ) e u 3 ( t ) - \u03b2 ( t ) \u222b - \u03c4 0 K ( s ) e u 3 ( t + s ) d s d t . Therefore, (3.3) \u222b 0 \u03c9 a 1 ( t ) e u 1 ( t ) d t + \u222b 0 \u03c9 b 1 ( t ) e u 3 ( t ) d t - \u2211 k = 1 q ln ( 1 + c k ) = \u222b 0 \u03c9 ( r 1 ( t ) - D 1 ( t ) ) d t + \u222b 0 \u03c9 D 1 ( t ) e u 2 ( t ) - u 1 ( t ) d t , (3.4) \u222b 0 \u03c9 a 2 ( t ) e u 2 ( t ) d t - \u2211 k = 1 q ln ( 1 + d k ) = \u222b 0 \u03c9 ( r 2 ( t ) - D 2 ( t ) ) d t + \u222b 0 \u03c9 D 2 ( t ) e u 1 ( t ) - u 2 ( t ) d t , (3.5) \u222b 0 \u03c9 b 3 ( t ) e u 3 ( t ) d t + \u222b 0 \u03c9 \u03b2 ( t ) \u222b - \u03c4 0 K ( s ) e u 3 ( t + s ) d s d t + \u222b 0 \u03c9 a 3 ( t ) e u 1 ( t ) d t - \u2211 k = 1 q ln ( 1 + e k ) = \u222b 0 \u03c9 r 3 ( t ) d t . Consequently, \u222b 0 \u03c9 | u \u02d9 1 ( t ) | d t \u2a7d 2 \u222b 0 \u03c9 a 1 ( t ) e u 1 ( t ) d t + \u222b 0 \u03c9 b 1 ( t ) e u 3 ( t ) d t - \u2211 k = 1 q ln ( 1 + c k ) , \u222b 0 \u03c9 | u \u02d9 2 ( t ) | d t \u2a7d 2 \u222b 0 \u03c9 a 2 ( t ) e u 2 ( t ) d t - \u2211 k = 1 q ln ( 1 + d k ) , \u222b 0 \u03c9 | u \u02d9 3 ( t ) | d t \u2a7d 2 \u222b 0 \u03c9 r 3 ( t ) d t + \u2211 k = 1 q ln ( 1 + e k ) = 2 r \u00af 3 \u03c9 + \u2211 k = 1 q ln ( 1 + e k ) = \u0394 d 3 . From Eq. (3.5) , we have \u222b 0 \u03c9 b 3 ( t ) e u 3 ( t ) d t - \u2211 k = 1 q ln ( 1 + e k ) \u2a7d \u222b 0 \u03c9 r 3 ( t ) d t and therefore, (3.6) \u222b 0 \u03c9 e u 3 ( t ) d t \u2a7d r 3 \u00af \u03c9 + \u2211 k = 1 q ln ( 1 + e k ) b 3 l . Let v ( t ) = max{ u 1 ( t ), u 2 ( t )}. Then v ( t ) \u2208 PC \u03c9 . Moreover, (1) If u 1 ( t ) > u 2 ( t ), or u 1 ( t ) = u 2 ( t ) but u \u02d9 1 ( t ) \u2a7e u \u02d9 2 ( t ) , then v ( t ) = u 1 ( t ) and u \u02d9 1 ( t ) \u2a7d \u03bb [ r 1 ( t ) - a 1 ( t ) e u 1 ( t ) ] \u2a7d \u03bb [ r 1 m - a 1 l e u 1 ( t ) ] . (2) If u 2 ( t ) > u 1 ( t ), or u 2 ( t ) = u 1 ( t ) but u \u02d9 2 ( t ) \u2a7e u \u02d9 1 ( t ) , then v ( t ) = u 2 ( t ) and u \u02d9 2 ( t ) \u2a7d \u03bb [ r 2 ( t ) - a 2 ( t ) e u 2 ( t ) ] \u2a7d \u03bb [ r 2 m - a 2 l e u 2 ( t ) ] . Denote r = max { r 1 m , r 2 m } and a = min { a 1 l , a 2 l } . Then (3.7) D + v ( t ) \u2a7d \u03bb [ r - a e v ( t ) ] , \u0394 v ( t k ) \u2a7d \u03bb ln ( 1 + B k ) , where B k = max{ c k , d k } ( k \u2208 Z + ). Integrating (3.7) over [0, \u03c9 ], we have - \u2211 k = 1 q ln ( 1 + B k ) \u2a7d r \u03c9 - a \u222b 0 \u03c9 e v ( t ) d t , which leads to \u222b 0 \u03c9 e v ( t ) d t \u2a7d [ r \u03c9 + \u2211 k = 1 q ln ( 1 + B k ) ] / a . Therefore, (3.8) \u222b 0 \u03c9 e u i ( t ) d t \u2a7d r \u03c9 + \u2211 k = 1 q ln ( 1 + B k ) a ( i = 1 , 2 ) . So, (3.9) \u222b 0 \u03c9 | u \u02d9 1 ( t ) | d t \u2a7d 2 a 1 m r a + b 1 m r 3 \u00af b 3 l \u03c9 + 2 a 1 m \u2211 k = 1 q ln ( 1 + B k ) a + b 1 m \u2211 k = 1 q ln ( 1 + e k ) b 3 l - \u2211 k = 1 q ln ( 1 + c k ) = \u0394 d 1 > 0 , \u222b 0 \u03c9 | u \u02d9 2 ( t ) | d t \u2a7d 2 a 2 m r a \u03c9 + 2 a 2 m \u2211 k = 1 q ln ( 1 + B k ) a - \u2211 k = 1 q ln ( 1 + d k ) = \u0394 d 2 > 0 . From Eq. (3.4) , we know that (3.10) \u222b 0 \u03c9 e u 2 ( t ) d t > ( r 2 - D 2 \u00af ) \u03c9 + \u2211 k = 1 q ln ( 1 + d k ) a 2 m . From Eq. (3.3) , we have \u222b 0 \u03c9 a 1 ( t ) e u 1 ( t ) d t - \u2211 k = 1 q ln ( 1 + c k ) \u2a7e ( r 1 - D 1 \u00af ) \u03c9 - \u222b 0 \u03c9 b 1 ( t ) e u 3 ( t ) d t and consequently (3.11) \u222b 0 \u03c9 e u 1 ( t ) d t \u2a7e ( r 1 - D 1 \u00af ) b 3 l - b 1 m r \u00af 3 a 1 m b 3 l \u03c9 - b 1 m \u2211 k = 1 q ln ( 1 + e k ) - b 3 l \u2211 k = 1 q ln ( 1 + c k ) a 1 m b 3 l > 0 . With equality (3.5) , we know that (3.12) b \u00af 3 + \u03b2 \u00af \u222b - \u03c4 0 K ( s ) d s exp max t \u2208 [ 0 , \u03c9 ] u 3 ( t ) \u2a7e r 3 \u00af \u03c9 - \u222b 0 \u03c9 a 3 ( t ) e u 1 ( t ) d t + \u2211 k = 1 q ln ( 1 + e k ) \u2a7e a r 3 \u00af - a 3 m r a \u03c9 + a \u2211 k = 1 q ln ( 1 + e k ) - a 3 m \u2211 k = 1 q ln ( 1 + B k ) a > 0 . Inequalities (3.6) and (3.8) show that there exist three points \u03c4 i \u2217 ( i = 1 , 2 , 3 ) such that (3.13) u i ( \u03c4 i \u2217 ) \u2a7d ln r \u03c9 + \u2211 k = 1 q ln ( 1 + B k ) a \u03c9 ( i = 1 , 2 ) , (3.14) u 3 ( \u03c4 3 \u2217 ) \u2a7d ln r \u00af 3 \u03c9 + \u2211 k = 1 q ln ( 1 + e k ) b 3 l \u03c9 . Consequently, there are three positive numbers \u03b4 i ( i = 1, 2, 3) such that (3.15) u i ( \u03c4 i \u2217 ) < \u03b4 i ( i = 1 , 2 , 3 ) . Similarly, inequalities (3.10)\u2013(3.12) show that there exist three points \u03be i \u2217 ( i = 1 , 2 , 3 ) and three positive numbers \u03c1 i ( i = 1, 2, 3) such that (3.16) u i ( \u03be i \u2217 ) > - \u03c1 i ( i = 1 , 2 , 3 ) . Since for an arbitrary t \u2208 [0, \u03c9 ], u 1 ( t ) = u 1 ( \u03c4 1 \u2217 ) + \u222b \u03c4 1 \u2217 t u \u02d9 1 ( s ) d s + \u03bb \u2211 \u03c4 1 \u2217 < t k \u2a7d t ln ( 1 + c k ) \u2a7d u 1 ( \u03c4 1 \u2217 ) + \u222b 0 \u03c9 | u \u02d9 1 ( s ) | d s + \u2211 0 < t k \u2a7d \u03c9 | ln ( 1 + c k ) | , u 2 ( t ) = u 2 ( \u03c4 2 \u2217 ) + \u222b \u03c4 2 \u2217 t u \u02d9 2 ( s ) d s + \u03bb \u2211 \u03c4 2 \u2217 < t k \u2a7d t ln ( 1 + d k ) \u2a7d u 2 ( \u03c4 2 \u2217 ) + \u222b 0 \u03c9 | u \u02d9 2 ( s ) | d s + \u2211 0 < t k \u2a7d \u03c9 | ln ( 1 + d k ) | , u 3 ( t ) = u 3 ( \u03c4 3 \u2217 ) + \u222b \u03c4 3 \u2217 t u \u02d9 3 ( s ) d s + \u03bb \u2211 \u03c4 3 \u2217 < t k \u2a7d t ln ( 1 + e k ) \u2a7d u 3 ( \u03c4 3 \u2217 ) + \u222b 0 \u03c9 | u \u02d9 3 ( s ) | d s + \u2211 0 < t k \u2a7d \u03c9 | ln ( 1 + e k ) | , u 1 ( t ) \u2a7e u 1 ( \u03be 1 \u2217 ) - \u222b 0 \u03c9 | u \u02d9 1 ( s ) | d s - \u2211 0 < t k \u2a7d \u03c9 | ln ( 1 + c k ) | , u 2 ( t ) \u2a7e u 2 ( \u03be 2 \u2217 ) - \u222b 0 \u03c9 | u \u02d9 2 ( s ) | d s - \u2211 0 < t k \u2a7d \u03c9 | ln ( 1 + d k ) | , u 3 ( t ) \u2a7e u 3 ( \u03be 3 \u2217 ) - \u222b 0 \u03c9 | u \u02d9 3 ( s ) | d s - \u2211 0 < t k \u2a7d \u03c9 | ln ( 1 + e k ) | and inequalities (3.15) and (3.16) , we have (3.17) - ( \u03c1 i + d i + \u03c3 i ) \u2a7d u i ( t ) \u2a7d \u03b4 i + d i + \u03c3 i ( i = 1 , 2 , 3 ) , where \u03c3 1 = \u2211 0 < t k \u2a7d \u03c9 | ln ( 1 + c k ) | , \u03c3 2 = \u2211 0 < t k \u2a7d \u03c9 | ln ( 1 + d k ) | , \u03c3 3 = \u2211 0 < t k \u2a7d \u03c9 | ln ( 1 + e k ) | . Therefore, | u i ( t ) | \u2a7d max { \u03c1 i + d i + \u03c3 i , \u03b4 i + d i + \u03c3 i } = \u0394 R i ( i = 1 , 2 , 3 ) . Obviously, R i ( i = 1, 2, 3) are independent of \u03bb . Now, we are in the position of proving all conditions of Lemma 2.1 are satisfied. Denote M = R 1 + R 2 + R 3 + R 0 , where R 0 is sufficiently large such that solution ( \u03b1 \u2217 , \u03b2 \u2217 , \u03b3 \u2217 ) T of the system (3.18) r 1 - D 1 \u00af - a \u00af 1 e x - b \u00af 1 e z + D \u00af 1 e y - x = - \u2211 k = 1 q ln ( 1 + c k ) , r 2 - D 2 \u00af - a \u00af 2 e y + D \u00af 2 e x - y = - \u2211 k = 1 q ln ( 1 + d k ) , r 3 \u00af - a \u00af 3 e x - b \u00af 3 + \u03b2 \u00af \u222b - \u03c4 0 K ( s ) d s e z = - \u2211 k = 1 q ln ( 1 + e k ) , satisfies \u2225( \u03b1 \u2217 , \u03b2 \u2217 , \u03b3 \u2217 ) T \u2225 = \u2223 \u03b1 \u2217 \u2223 + \u2223 \u03b2 \u2217 \u2223 + \u2223 \u03b3 \u2217 \u2223 < M , provided that system (3.18) has a solution or a number of solutions. Let \u03a9 = {( u 1 ( t ), u 2 ( t ), u 3 ( t )) T \u2208 X , \u2225( u 1 ( t ), u 2 ( t ), u 3 ( t )) T \u2225 < M }. Then condition (a) of Lemma 2.1 is satisfied. For each ( u 1 , u 2 , u 3 ) T \u2208 \u2202 \u03a9 \u2229 Ker L = \u2202 \u03a9 \u2229 R 3 , we know that ( u 1 ( t ), u 2 ( t ), u 3 ( t )) T is a constant vector in R 3 with \u2211 i = 1 3 | u i | = M . If system (3.18) has a solution or a number of solutions, then QN u 1 ( t ) u 2 ( t ) u 3 ( t ) = r 1 - D 1 \u00af - a \u00af 1 e u 1 - b \u00af 1 e u 3 + D \u00af 1 e u 2 - u 1 + \u2211 k = 1 q ln ( 1 + c k ) r 2 - D 2 \u00af - a \u00af 2 e u 2 + D \u00af 2 e u 1 - u 2 + \u2211 k = 1 q ln ( 1 + d k ) r \u00af 3 - a \u00af 3 e u 1 - b \u00af 3 + \u03b2 \u00af \u222b - \u03c4 0 K ( s ) d s e u 3 + \u2211 k = 1 q ln ( 1 + e k ) , 0 0 0 , \u2026 , 0 0 0 \u2260 0 0 0 , 0 0 0 , \u2026 , 0 0 0 . If system (3.18) does not have any solution, naturally, QN u 1 ( t ) u 2 ( t ) u 3 ( t ) \u2260 0 0 0 , 0 0 0 , \u2026 , 0 0 0 , which shows that condition (b) in Lemma 2.1 is satisfied. Finally, we prove that condition (c) in Lemma 2.1 is satisfied. Define \u03a6 : Dom L \u00d7 [0, 1] \u2192 X , \u03a6 ( u 1 , u 2 , u 3 , \u03bc ) = r 1 - D 1 \u00af - a \u00af 1 e u 1 - b \u00af 1 e u 3 + \u2211 k = 1 q ln ( 1 + c k ) r 2 - D 2 \u00af - a \u00af 2 e u 2 + \u2211 k = 1 q ln ( 1 + d k ) r 3 \u00af - a \u00af 3 e u 1 - b \u00af 3 + \u03b2 \u00af \u222b - \u03c4 0 K ( s ) d s e u 3 + \u2211 k = 1 q ln ( 1 + e k ) + \u03bc D \u00af 1 e u 2 - u 1 D \u00af 2 e u 1 - u 2 0 , where \u03bc \u2208 [0, 1] is a parameter. With the mapping \u03a6 , we have \u03a6 ( u 1 , u 2 , u 3 , \u03bc ) \u2260 0 for ( u 1 , u 2 , u 3 ) T \u2208 \u2202 \u03a9 \u2229 Ker L . Assuming that this is not true, then there exists a constant vector ( u 1 , u 2 , u 3 ) T with \u2211 i = 1 3 | u i | = M satisfying \u03a6 ( u 1 , u 2 , u 3 , \u03bc ) = 0, i.e. r 1 - D 1 \u00af - a \u00af 1 e u 1 - b \u00af 1 e u 3 + \u03bc D \u00af 1 e u 2 - u 1 + \u2211 k = 1 q ln ( 1 + c k ) = 0 , r 2 - D 2 \u00af - a \u00af 2 e u 2 + \u03bc D \u00af 2 e u 1 - u 2 + \u2211 k = 1 q ln ( 1 + d k ) = 0 , r 3 \u00af - a \u00af 3 e u 1 - b \u00af 3 + \u03b2 \u00af \u222b - \u03c4 0 K ( s ) d s e u 3 + \u2211 k = 1 q ln ( 1 + e k ) = 0 . Following the discussion of (3.13)\u2013(3.18) , we know that \u2223 u i \u2223 < max{ \u03b4 i , \u03c1 i }. Therefore \u2211 i = 1 3 | u i | < M , which contradicts \u2211 i = 1 3 | u i | = M . Using the property of topological degree and taking J : Im Q \u2192 Ker L by J 1 \u03c9 \u222b 0 \u03c9 u 1 ( t ) d t + \u2211 k = 1 q m k \u222b 0 \u03c9 u 2 ( t ) d t + \u2211 k = 1 q n k \u222b 0 \u03c9 u 3 ( t ) d t + \u2211 k = 1 q p k , 0 0 0 , \u2026 , 0 0 0 = 1 \u03c9 \u222b 0 \u03c9 u 1 ( t ) d t + \u2211 k = 1 q m k \u222b 0 \u03c9 u 2 ( t ) d t + \u2211 k = 1 q n k \u222b 0 \u03c9 u 3 ( t ) d t + \u2211 k = 1 q p k , we have deg ( JQN ( u 1 , u 2 , u 3 ) T , \u03a9 \u2229 Ker L , ( 0 , 0 , 0 ) T ) = deg ( \u03a6 ( u 1 , u 2 , u 3 , 1 ) , \u03a9 \u2229 Ker L , ( 0 , 0 , 0 ) T ) = deg ( \u03a6 ( u 1 , u 2 , u 3 , 0 ) , \u03a9 \u2229 Ker L , ( 0 , 0 , 0 ) T ) = deg r 1 - D 1 \u00af - a \u00af 1 e u 1 - b \u00af 1 e u 3 + \u2211 k = 1 q ln ( 1 + c k ) , r 2 - D 2 \u00af - a \u00af 2 e u 2 + \u2211 k = 1 q ln ( 1 + d k ) , r \u00af 3 - a \u00af 3 e u 1 - b \u00af 3 + \u03b2 \u00af \u222b - \u03c4 0 K ( s ) d s e u 3 + \u2211 k = 1 q ln ( 1 + e k ) T , \u03a9 \u2229 Ker L , ( 0 , 0 , 0 ) T . By the hypotheses of the theorem, the algebraic system r 1 - D 1 \u00af - a \u00af 1 x 1 - b \u00af 1 y + \u2211 k = 1 q ln ( 1 + c k ) = 0 , r 2 - D 2 \u00af - a \u00af 2 x 2 + \u2211 k = 1 q ln ( 1 + d k ) = 0 , r \u00af 3 - a \u00af 3 x 1 - b \u00af 3 + \u03b2 \u00af \u222b - \u03c4 0 K ( s ) d s y + \u2211 k = 1 q ln ( 1 + e k ) = 0 , has a unique solution ( x 1 \u2217 , x 2 \u2217 , y \u2217 ) T , where x 1 \u2217 = a \u00af 1 r \u00af 3 + \u2211 k = 1 q ln ( 1 + e k ) - a \u00af 3 r 1 - D 1 \u00af + \u2211 k = 1 q ln ( 1 + c k ) a \u00af 1 b \u00af 3 + \u03b2 \u00af \u222b - \u03c4 0 K ( s ) d s - a \u00af 3 b \u00af 1 > 0 , x 2 \u2217 = r 2 - D 2 \u00af + \u2211 k = 1 q ln ( 1 + d k ) a \u00af 2 > 0 , y \u2217 = r 1 - D 1 \u00af + \u2211 k = 1 q ln ( 1 + c k ) b \u00af 3 + \u03b2 \u00af \u222b - \u03c4 0 K ( s ) d s - b \u00af 1 r \u00af 3 + \u2211 k = 1 q ln ( 1 + e k ) a \u00af 1 b \u00af 3 + \u03b2 \u00af \u222b - \u03c4 0 K ( s ) d s - a \u00af 3 b \u00af 1 > 0 . Consequently, we have deg ( JQN ( u 1 , u 2 , u 3 ) T , \u03a9 \u2229 Ker L , ( 0 , 0 , 0 ) T ) = sign a \u00af 3 a \u00af 2 b \u00af 1 - a \u00af 1 a \u00af 2 b \u00af 3 + \u03b2 \u00af \u222b - \u03c4 0 K ( s ) d s x 1 \u2217 x 2 \u2217 y \u2217 = 1 . And the proof is completed. \u25a1 In fact, let c k = d k = e k = 0, then the above system (1.1) is the system (1.1) in [1] , and conditions (1), (2) and (3) of Theorem 3.1 are identical with (H3), (H4) and ( H 5 \u2032 ) of Theorem 2.1\u2032 . Example\u00a01 Consider the system (3.19) x 1 \u02d9 ( t ) = x 1 ( t ) ( 2 + sin t ) - ( 2 + sin t ) x 1 ( t ) - y ( t ) + 5 4 + sin t ( x 2 ( t ) - x 1 ( t ) ) , x 2 \u02d9 ( t ) = x 2 ( t ) ( 2 + cos t ) - ( 2 + sin t ) x 2 ( t ) + 5 4 + cos t ( x 1 ( t ) - x 2 ( t ) ) , y \u02d9 ( t ) = y ( t ) 4 + sin t 2 \u03c0 - 1 2 \u03c0 x 1 ( t ) - ( 2 + sin t ) y ( t ) . It is easily proved that this system satisfies (H3), (H4) and ( H 5 \u2032 ) , and has at least one positive 2\u03c0-periodic solution ( Fig. 1 ). Example\u00a02 For the system (3.20) x 1 \u02d9 ( t ) = x 1 ( t ) ( 2 + sin t ) - ( 2 + sin t ) x 1 ( t ) - y ( t ) + 5 4 + sin t ( x 2 ( t ) - x 1 ( t ) ) , x 2 \u02d9 ( t ) = x 2 ( t ) ( 2 + cos t ) - ( 2 + sin t ) x 2 ( t ) + 5 4 + cos t ( x 1 ( t ) - x 2 ( t ) ) , y \u02d9 ( t ) = y ( t ) 4 + sin t 2 \u03c0 - 1 2 \u03c0 x 1 ( t ) - ( 2 + sin t ) y ( t ) , t \u2260 t k , \u0394 y ( t k ) = 0.05 y ( t k ) , where t k = 2 k \u03c0, k \u2208 Z + . It can be verified that all the conditions of Theorem 3.1 hold, so there exists at least one positive 2\u03c0-periodic solution for this impulsive differential system ( Fig. 2 ). 4 Conclusion In this paper, we study a two-species periodic competition system with diffusion and impulses. In fact, system (1.1) with c k = d k = e k = 0 ( k \u2208 N ) was discussed in paper [1] . Here, we re-estimate the upper bounds of \u222b 0 \u03c9 e u i ( t ) d t ( i = 1, 2) by constructing the special function v ( t ) = max{ u 1 ( t ), u 2 ( t )}, then the conditions of Theorem 2.1 in [1] , which guarantee the existence of a positive periodic solution, are simplified. Further, the impulsive effects are considered besides the diffusion of species X between two patches, and a periodic competition system with diffusion and impulses is established. With the theory of topological degree, the existence of a positive periodic solution for such an impulsive differential system is obtained. Moreover, some examples are given to illustrate our results. How to prove the stability of positive periodic solutions will be our future work. References [1] Z. Zhang Z. Wang Periodic solution for a two-species competition Lotka\u2013Volterra patch system with time delay J Math Anal Appl 265 2002 38 48 [2] X. Song L. Chen Persistence and global stability for nonautonomous predator\u2013prey system with diffusion and time-delay Comput Math Appl 35 6 1998 33 40 [3] J.M. Cushing Periodic time-dependent predator\u2013prey system SIAM J Appl Math 32 1977 82 95 [4] J.M. Cushing Periodic Kolmogrov system SIAM J Math Anal 13 1982 811 827 [5] Y. Li On a periodic neutral delay Lotka\u2013Volterra system Nonlinear Anal 39 6 2000 767 778 [6] X. Song L. Chen Persistence and periodic orbits for two-species predator\u2013prey system with diffusion Can. Appl. Math. Quart. 6 3 1998 [7] J.C. Panetta A mathematical model of periodically pulsed chemotherapy: tumor recurrence and metastasis in a competition environment Bull Math Biol 58 1996 425 447 [8] G. Ballinger X. Liu Permanence of population growth models with impulsive effects Math Comput Modell 26 1997 59 72 [9] M.G. Roberts R.R. Kao The dynamics of an infectious disease in a population with birth pulse Math Biosci 149 1998 23 26 [10] Sanyi Tang Lansun Chen Density-dependent birth rate, birth pulse and their population dynamic consequences J Math Biol 44 2 2002 185 199 [11] R.E. Gains J.L. Mawhin Coincidence degree and nonlinear differential equations 1977 Springer-Verlag Berlin [12] J. Zhen Z. Ma M. Han The existence of periodic solutions of the n -species Lotka\u2013Volterra competition systems with impulsive Chaos, Solitons & Fractals 22 2004 181 188 [13] S. Zhang D. Tan L. Chen The periodic n -species Gilpin\u2013Ayala competition system with impulsive effect Chaos, Solitons & Fractals 26 2005 507 517",
        "keywords": [
            "upper bound"
        ],
        "authors": [
            {
                "name": "Lingzhen Dong",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116023, China"
            },
            {
                "name": "Peilin Shi",
                "org": "Department of Mathematics, Taiyuan University of Technology, Taiyuan 030024, China"
            }
        ],
        "venue": "Chaos, Solitons and Fractals",
        "year": 2007
    },
    "l8XO2yxV": {
        "id": "l8XO2yxV",
        "title": "The study of a ratio-dependent predator\u2013prey model with stage structure in the prey",
        "abstract": "In this paper, a ratio-dependent predator\u2013prey model with stage structure in the prey is constructed and investigated. In\n the first part of this paper, some sufficient conditions for the existence and stability of three equilibriums are obtained.\n In the second part, we consider the effect of impulsive release of predator on the original system. A sufficient condition\n for the global asymptotical stability of the prey-eradication periodic solution is obtained. We also get the condition, under\n which the prey would never be eradicated, i.e., the impulsive system is permanent. At last, we give a brief discussion.",
        "keywords": [
            "Ratio-dependent",
            "Stage structure",
            "Predator\u2013prey",
            "Impulsive",
            "Permanent",
            "Prey-eradication periodic solution"
        ],
        "authors": [
            {
                "name": "Ruiqing Shi",
                "org": "Shanxi Normal University School of Mathematics and Computer Science Linfen 041004 People\u2019s Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116024 People\u2019s Republic of China"
            }
        ],
        "venue": "Nonlinear Dynamics",
        "year": 2009
    },
    "HCjkUlXT": {
        "id": "HCjkUlXT",
        "title": "Dynamic behaviors of Monod type chemostat model with impulsive perturbation on the nutrient concentration",
        "abstract": "In this paper, the dynamic behaviors of a Monod type chemostat model with impulsive perturbation are investigated. Using Floquet\n theory and small amplitude perturbation method, we prove that the microorganism-eradication periodic solution is asymptotically\n stable if the impulsive period satisfies some conditions. Moreover, the permanence of the system is discussed in detail. Finally,\n we verify the main results by numerical simulation.\n ",
        "keywords": [
            "chemostat",
            "impulsive input",
            "extinction",
            "permanence",
            "34K45",
            "34K60",
            "92D25",
            "92D40"
        ],
        "authors": [
            {
                "name": "Shulin Sun",
                "org": "Dalian University of Technology Department of Applied Mathematics Liaoning Dalian 116024 P.R.China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology Department of Applied Mathematics Liaoning Dalian 116024 P.R.China"
            }
        ],
        "venue": "Journal of Mathematical Chemistry",
        "year": 2007
    },
    "bjZOC4Bi": {
        "id": "bjZOC4Bi",
        "title": "Dynamics Analysis for a Three-dimensional Chemostat Model with Impulsive Diffusion",
        "abstract": "In this paper,we consider a three dimensional chemostat model with impulsive diffusion.Using the discrete dynamical system determined by the stroboscopic map,we obtain a microorganism extinction periodic solution.Further,it is globally asymptotically stable.The permanent condition of the investigated system is also analyzed by the theory on impulsive differential equation.Our results reveal that the envionmental changes of the chemostat play important roles on the outcome of the chemostat.",
        "keywords": [
            "Permanence",
            "Extinction",
            "Chemostat model",
            "Impulsive diffusion"
        ],
        "authors": [
            {
                "name": "JIAO Jianjun",
                "org": "1.School of Mathematics and Statistics,Guizhou Key Laboratory of Economic System Simulation,Guizhou College of Finance & Economics,Guiyang ,China"
            },
            {
                "name": "CHEN Lansun",
                "org": "2.Institute of Mathematics,Academia Sinica,Beijing ,China"
            }
        ],
        "venue": "Mathematica Applicata",
        "year": 2011
    },
    "4ITWwdbZ": {
        "id": "4ITWwdbZ",
        "title": "Impulsive vaccination of sir epidemic models with nonlinear incidence rates",
        "abstract": "",
        "keywords": [
            "Bifurcation",
            "Impulsive vaccination",
            "Nonlinear incidence rates",
            "Stability",
            "Threshold"
        ],
        "authors": [
            {
                "name": "Jing Hui",
                "org": "Guangxi University of Technology(Guangxi University of Technology ^),Liuzhou,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and System Sciences Chinese Academy of Sciences(Chinese Academy of Sciences,Academy of Mathematics and Systems Science),Beijing,China"
            }
        ],
        "venue": "Discrete and Continuous Dynamical Systems - Series B",
        "year": 2004
    },
    "gqXnjd7E": {
        "id": "gqXnjd7E",
        "title": "Global dynamics behaviors for new delay SEIR epidemic disease model with vertical transmission and pulse vaccination",
        "abstract": "A robust SEIR epidemic disease model with a profitless delay and vertical transmission is formulated, and the dynamics behaviors of the model under pulse vaccination are analyzed. By use of the discrete dynamical system determined by the stroboscopic map, an 'infection-free' periodic solution is obtained, further, it is shown that the 'infection-free' periodic solution is globally attractive when some parameters of the model are under appropriate conditions. Using the theory on delay functional and impulsive differential equation, the sufficient condition with time delay for the permanence of the system is obtained, and it is proved that time delays, pulse vaccination and vertical transmission can bring obvious effects on the dynamics behaviors of the model. The results indicate that the delay is 'profitless'. \u00a9 2007 Editorial Committee of Appl. Math. Mech.",
        "keywords": [
            "Delays",
            "Global attractivity",
            "Horizontal and vertical transmission",
            "Permanence",
            "Pulse vaccination"
        ],
        "authors": [
            {
                "name": "MENG Xin-zhu",
                "org": "Shandong University of Science and Technology(Shandong University of Science and Technology,Shandong Univ. of Sci. and Technol.),Qingdao,China"
            },
            {
                "name": "CHEN Lan-sun",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            },
            {
                "name": "SONG Zhi-tao",
                "org": "Shandong University of Science and Technology(Shandong University of Science and Technology,Shandong Univ. of Sci. and Technol.),Qingdao,China"
            }
        ],
        "venue": "Applied Mathematics and Mechanics (English Edition)",
        "year": 2007
    },
    "RI4M0fzy": {
        "id": "RI4M0fzy",
        "title": "Extinction and permanence of the predator-prey system with stocking of prey and harvesting of predator impulsively",
        "abstract": "",
        "keywords": [
            "extinction",
            "impulsive perturbation",
            "permanence",
            "predator-prey system"
        ],
        "authors": [
            {
                "name": "Lingzhen Dong",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            },
            {
                "name": "Lihua Sun",
                "org": ""
            }
        ],
        "venue": "Mathematical Methods in The Applied Sciences",
        "year": 2006
    },
    "Piv17dhe": {
        "id": "Piv17dhe",
        "title": "Conditions for Global Attractivity of n-Patches Predator\u2013Prey Dispersion-Delay Models",
        "abstract": "In this paper, a nonautonomous predator\u2013prey dispersion model with functional response and continuous time delay is studied, where all parameters are time dependent. In this system, which consists of n -patches, the prey species can disperse among n -patches, but the predator species is confined to one patch and cannot disperse. It is proved the system is uniformly persistent under any dispersion rate effect. Furthermore, the sufficient conditions are established for global attractivity of a periodic solution of the system.",
        "keywords": [
            "dispersion",
            "persistence",
            "delay",
            "predator\u2013prey system",
            "global attractivity",
            "functional response"
        ],
        "authors": [
            {
                "name": "Xinyu Song",
                "org": "Institute of Mathematics, Academia Sinica, Beijing, 100080, People's Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Journal of Mathematical Analysis and Applications",
        "year": 2001
    },
    "oalra6q6": {
        "id": "oalra6q6",
        "title": "DYNAMICS OF A NONAUTONOMOUS SYSTEM WITH IMPULSIVE OUTPUT",
        "abstract": "",
        "keywords": [
            "impulsive",
            "nonautonomous system",
            "persistence",
            "stability"
        ],
        "authors": [
            {
                "name": "YUANSHUN TAN",
                "org": ""
            },
            {
                "name": "FENGMEI TAO",
                "org": ""
            },
            {
                "name": "LANSUN CHEN",
                "org": ""
            }
        ],
        "venue": "International Journal of Biomathematics",
        "year": 2008
    },
    "4sUJVFRr": {
        "id": "4sUJVFRr",
        "title": "Complex Dynamics of One-prey Multi-predator System with Defensive Ability of prey and impulsive Biological Control on Predators",
        "abstract": "",
        "keywords": [
            "defensive ability",
            "extinction",
            "impulsive biological control",
            "permanence",
            "complex dynamics",
            "critical value",
            "biological control"
        ],
        "authors": [
            {
                "name": "Yongzhen Pei",
                "org": ""
            },
            {
                "name": "Changguo Li",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            },
            {
                "name": "Chunhua Wang",
                "org": ""
            }
        ],
        "venue": "Advances in Complex Systems",
        "year": 2005
    },
    "XAJmFUsp": {
        "id": "XAJmFUsp",
        "title": "Delayed stage-structured predator-prey model with impulsive perturbations on predator and chemical control on prey",
        "abstract": "A delayed stage-structured pest management predator-prey system with impulsive transmitting on predators and chemical on prey concern was considered.Sufficient conditions of the global attractivity of pest-extinction boundary periodic solution and permanence of the system were obtained.It was also proved that all solutions of the system are uniformly ultimately bounded.The results provide reliable tactical basis for the practical pest management.",
        "keywords": [
            "delayed",
            "pestextinction",
            "impulsive",
            "permanence",
            "stage-structured",
            "global attractivity",
            "pest-extinction",
            "O175.2",
            "O175.6",
            "34A37",
            "92B05"
        ],
        "authors": [
            {
                "name": "Jian-jun Jiao",
                "org": "Guizhou College of Finance & Economics School of Mathematics and Statistics Guiyang 550004 P. R. China"
            },
            {
                "name": "Lan-sun Chen",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116024 P. R. China"
            }
        ],
        "venue": "Applied Mathematics and Mechanics-english Edition",
        "year": 2007
    },
    "kA9R20TU": {
        "id": "kA9R20TU",
        "title": "Periodic solution and heteroclinic bifurcation in a predator\u2013prey system with Allee effect and impulsive harvesting",
        "abstract": "In this article, we investigate a prey\u2013 predator model with Allee effect and state-dependent impulsive harvesting. We obtain the sufficient conditions for the existence and uniqueness of order-1 periodic solution of system () by means of the geometry theory of semicontinuous dynamic system and the method of successor function. We also obtain that system () exhibits the phenomenon of heteroclinic bifurcation about parameter . The methods used in this article are novel and prove the existence of order-1 periodic solution and heteroclinic bifurcation.",
        "keywords": [
            "Semicontinuous dynamic system",
            "Successor function",
            "Order-1 periodic solution",
            "Order-1 heteroclinic cycle",
            "Heteroclinic bifurcation"
        ],
        "authors": [
            {
                "name": "chunjin wei",
                "org": "jimei university"
            },
            {
                "name": "lansun chen",
                "org": "chinese academy of sciences"
            }
        ],
        "venue": "Nonlinear Dynamics",
        "year": 2013
    },
    "3aVqFosN": {
        "id": "3aVqFosN",
        "title": "Permanence and Complexity of a Three Species Food Chain with Impulsive Effect on the Top Predator",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "lihua sun",
                "org": ""
            },
            {
                "name": "lansun chen",
                "org": ""
            },
            {
                "name": "shuwen zhang",
                "org": ""
            },
            {
                "name": "fengyan wang",
                "org": ""
            }
        ],
        "venue": "International Journal of Nonlinear Sciences and Numerical Simulation",
        "year": 2005
    },
    "OijkYKsA": {
        "id": "OijkYKsA",
        "title": "Existence of periodic solution of order one of planar impulsive autonomous system",
        "abstract": "Based on the situation that all the recent research about state-dependent impulsive differential equations is focused on systems which have explicit solutions, this paper try to consider those systems with state-dependent impulsion which have not explicit solutions. We get an existence theorem of periodic solution of order one for a general planar autonomous impulsive system, and, by applying it to a special state-dependent impulsive differential equations we get the concrete conditions of existence of one-order periodic solution of that special system.",
        "keywords": [
            "periodic solution",
            "planar impulsive autonomous system",
            "special system",
            "state-dependent impulsion",
            "existence theorem",
            "state-dependent impulsive differential equation",
            "one-order periodic solution",
            "planar autonomous impulsive system",
            "explicit solution",
            "concrete condition",
            "special state-dependent impulsive differential",
            "state dependent"
        ],
        "authors": [
            {
                "name": "Guangzhao Zeng",
                "org": "Department of Mathematics, Shaoguan University, ShaoGuan, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian, PR China"
            },
            {
                "name": "Lihua Sun",
                "org": "Department of Mathematics, Shaoguan University, ShaoGuan, PR China"
            }
        ],
        "venue": "Journal of Computational and Applied Mathematics",
        "year": 2006
    },
    "KKbrNuJF": {
        "id": "KKbrNuJF",
        "title": "Harvesting Control for a Stage-Structured Predator-Prey Model with Ivlev's Functional Response and Impulsive Stocking on Prey",
        "abstract": "",
        "keywords": [
            "functional response"
        ],
        "authors": [
            {
                "name": "Kaiyuan Liu",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Discrete Dynamics in Nature and Society",
        "year": 2007
    },
    "qDngRKMm": {
        "id": "qDngRKMm",
        "title": "Asymptotic behavior of discrete solutions to delayed neural networks with impulses",
        "abstract": "In this paper, we formulate and study a new class of discrete neural networks with time dependent delay and impulses. Sufficient conditions for the asymptotic stability of a unique equilibrium of the networks with Lipschitizian activation functions are established. Also when the impulsive jumps are absent the results reduce to those of non-impulsive networks.",
        "keywords": [
            "sufficient condition",
            "delayed neural network",
            "39a11",
            "impulse",
            "impulsive jump",
            "new class",
            "asymptotic stability",
            "92b20",
            "non-impulsive network",
            "hopfield networks",
            "time dependent delay",
            "asymptotic behavior",
            "34k45",
            "lipschitizian activation function",
            "discrete neural network",
            "unique equilibrium",
            "discrete solution",
            "discrete-time analogues",
            "neural network",
            "activation function",
            "hopfield network",
            "discrete time"
        ],
        "authors": [
            {
                "name": "Hong Zhang",
                "org": "Department of Mathematics, Jiangsu University, ZhenJiang, JiangSu, 212013, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, DaLian, LiaoNing, 116024, PR China"
            }
        ],
        "venue": "Neurocomputing",
        "year": 2008
    },
    "hHsgsLCh": {
        "id": "hHsgsLCh",
        "title": "ON A PERIODIC TIME-DEPENDENT IMPULSIVE SYSTEM OF STRATEGIES FOR CONTROLLING THE APPLE SNAIL IN PADDY FIELDS",
        "abstract": "",
        "keywords": [
            "apple snail",
            "impulsive perturbation",
            "paddy field",
            "permanence",
            "predator-prey system",
            "stage structure"
        ],
        "authors": [
            {
                "name": "HONG ZHANG",
                "org": ""
            },
            {
                "name": "RONGPING ZHU",
                "org": ""
            },
            {
                "name": "LANSUN CHEN",
                "org": ""
            }
        ],
        "venue": "Journal of Biological Systems",
        "year": 2007
    },
    "MPY2fGzD": {
        "id": "MPY2fGzD",
        "title": "Global analysis of a three-dimensional delayed Michaelis-Menten chemostat-type models with pulsed input",
        "abstract": "In this paper, a new three-dimensional Michaelis-Menten type chemostat model with time delay and pulsed input nutrient concentration\n is considered. By means of a fixed point in Poincare map for the discrete dynamical system, we obtain a semi-trivial periodic\n solution, further, we establish the sufficient conditions for the global attractivity of the semi-trivial periodic solution.\n By use of new computational techniques for impulsive and delayed differential equation, we prove that the system is permanent\n under appropriate conditions. Our results show that time delays are \u201cprofitless\u201d. The results are further substantiated by\n numerical simulation.",
        "keywords": [
            "permanence \u00b7 impulsive input \u00b7 michaelis-menten type chemostat model \u00b7 time delay for growth response \u00b7 extinction",
            "global analysis",
            "fixed point",
            "numerical simulation",
            "three dimensional",
            "poincare map",
            "delay differential equation"
        ],
        "authors": [
            {
                "name": "Tieying Wang",
                "org": "School of Mathematical Sciences, Dalian University of Technology, Dalian, 116024 People\u2019s Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "School of Mathematical Sciences, Dalian University of Technology, Dalian, 116024 People\u2019s Republic of China"
            }
        ],
        "venue": "Journal of Applied Mathematics and Computing",
        "year": 2011
    },
    "3pqHlGtr": {
        "id": "3pqHlGtr",
        "title": "Global stability in a periodic delayed predator\u2013prey system",
        "abstract": "In this paper, we establish a periodic delayed predator\u2013prey system according to two types of single-species growth population models with delay. By using some analysis methods, easily verifiable sufficient conditions for the existence and global asymptotic stability of positive periodic solution of the above system are derived. Some previous results are generalized and improved. Biological interpretations on the main results are also given.",
        "keywords": [
            "global asymptotic stability",
            "lyapunov functional",
            "delay predator\u2013prey system",
            "periodic solution",
            "coincidence degree",
            "lyapunov function",
            "population model"
        ],
        "authors": [
            {
                "name": "Zhijun Liu",
                "org": ""
            },
            {
                "name": "Ronghua Tan",
                "org": "Department of Mathematics, Hubei Institute for Nationalities, 445000 Enshi Hubei, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, 116024 Dalian Liaoning, PR China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2007
    },
    "qgDsHHJh": {
        "id": "qgDsHHJh",
        "title": "Global stability of a predator-prey system with stage structure for the predator",
        "abstract": "In this paper, some feasibly sufficient conditions are obtained for the global asymptotic stability of a positive steady state of a predator-prey system with stage structure for the predator by using the theory of competitive systems, compound matrices and stability of periodic orbits, and then the work of Wang [4] is improved. \u00a9 Springer-Verlag 2004.",
        "keywords": [
            "competitive systems",
            "global stability",
            "predator-prey system",
            "stage structure"
        ],
        "authors": [
            {
                "name": "Yan Ni Xiao",
                "org": "University of Liverpool(University of Liverpool),Liverpool,United Kingdom"
            },
            {
                "name": "Lan Sun Chen",
                "org": "Academy of Mathematics and System Sciences Chinese Academy of Sciences(Chinese Academy of Sciences,Academy of Mathematics and Systems Science),Beijing,China"
            }
        ],
        "venue": "Acta Mathematica Sinica, English Series",
        "year": 2004
    },
    "v2VmKedC": {
        "id": "v2VmKedC",
        "title": "Analyses of complexities in a single-species discrete model with stage structure and birth pulses",
        "abstract": "Two single-species discrete models with stage structure are proposed and analyzed. For the model without impulse, sufficient conditions for global asymptotic stability of trivial equilibrium and positive equilibrium are obtained. For the model with time-dependent birth pulses, using the stroboscopic map, the theory on bifurcation and numerical analysis, the existence and stability of the positive equilibrium are obtained. Bifurcation diagrams are constructed with the birth rate as the bifurcation parameter, and they are observed to display complex dynamic behaviors, including chaotic bands, doubling-bifurcation, halving-bifurcation and coexistence of several attractors. It is pointed out that birth pulses provide a natural period or cyclicity that makes the dynamic behaviors more complicated.",
        "keywords": [
            "Birth pulse",
            "Chaos",
            "Discrete model",
            "Stage structure"
        ],
        "authors": [
            {
                "name": "GAO Shu-jing",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            },
            {
                "name": "CHEN Lan-sun",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            }
        ],
        "venue": "Dalian Ligong Daxue Xuebao/Journal of Dalian University of Technology",
        "year": 2006
    },
    "v5Cyyjc6": {
        "id": "v5Cyyjc6",
        "title": "Dynamical analysis of a delayed predator-prey model with impulsive diffusion between two patches",
        "abstract": "In this work, we propose a delayed predator-prey model with impulsively diffusive prey between two patches. Using the stroboscopic map of the discrete dynamical system, we obtain the globally attractive condition of predator-extinction periodic solution of the system. We also obtain the permanent condition of the system by the theory of impulsive delay differential equation. Our results indicate that the discrete time delay has influence to the dynamical behaviors of the system. Finally, the numerical analysis is inserted to illustrate the results.",
        "keywords": [
            "delayed predator-prey model",
            "extinction",
            "discrete dynamical system",
            "impulsive delay differential equation",
            "impulsive diffusion",
            "numerical analysis",
            "dynamical analysis",
            "discrete time delay",
            "predator\u2013prey model",
            "permanent",
            "attractive condition",
            "predator-extinction periodic solution",
            "impulsively diffusive prey",
            "permanent condition",
            "dynamical behavior",
            "dynamic analysis"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": "School of Mathematics and Statistics, Huazhong University of Science and Technology, Wuhan 430074, PR China and Guizhou Key Laboratory of Economic System Simulation, Guizhou College of Finance and ..."
            },
            {
                "name": "Xiaosong Yang",
                "org": "School of Mathematics and Statistics, Huazhong University of Science and Technology, Wuhan 430074, PR China"
            },
            {
                "name": "Shaohong Cai",
                "org": "Guizhou Key Laboratory of Economic System Simulation, Guizhou College of Finance and Economics, Guiyang 550004, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academia Sinica, Beijing 100080, PR China"
            }
        ],
        "venue": "Mathematics and Computers in Simulation",
        "year": 2009
    },
    "5KomvdzZ": {
        "id": "5KomvdzZ",
        "title": "Impulsive control strategy of a pest management SI model with nonlinear incidence rate",
        "abstract": "In this work, we consider a pest management SI model with impulsive release of infective pests and spraying pesticides. We prove that all solutions of the investigated system are uniformly ultimately bounded and the pest-extinction periodic solution is globally asymptotically stable when some condition is satisfied. We also obtain the permanent condition of the system. It is concluded that the approach of combining impulsive release of infective pests with impulsive spraying pesticides provides reliable tactic basis for the practical pest management.",
        "keywords": [
            "Chemical control",
            "Impulsive",
            "Infective pest",
            "Pest-extinction"
        ],
        "authors": [
            {
                "name": "Jian-jun Jiao",
                "org": ""
            },
            {
                "name": "Lan-sun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, People\u2019s Republic of China"
            },
            {
                "name": "Shao-hong Cai",
                "org": "Guizhou College of Finance and Economics, Guiyang 550004, People\u2019s Republic of China"
            }
        ],
        "venue": "Applied Mathematical Modelling",
        "year": 2009
    },
    "R6u9nDzY": {
        "id": "R6u9nDzY",
        "title": "Extinction and Permanence of a General Predator-Prey System with Impulsive Perturbations.",
        "abstract": "A general predator-prey system is studied in a scheme where there is periodic impulsive perturbations. This scheme has the potential to protect the predator from extinction but under some conditions may also serve to lead to extinction of the prey. Conditions for extinction and permanence are obtained via the comparison methods involving monotone theory of impulsive systems and multiple Liapunov functions, which establish explicit bounds on solutions. The existence of a positive periodic solution is also studied by the bifurcation theory. Application is given to a Lotka-Volterra predator-prey system with periodic impulsive immigration of the predator. It is shown that the results are quite different from the corresponding system without impulsive immigration, where extinction of the prey can never be achieved. The prey will be extinct or permanent independent of whether the system without impulsive effect immigration is permanent or not. The model and its results suggest an approach of pest control which proves more effective than the classical one. \u00a9 2012 Xianning Liu and Lansun Chen.",
        "keywords": [],
        "authors": [
            {
                "name": "Xianning Liu",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "J. Applied Mathematics",
        "year": 2012
    },
    "7MqZTvnh": {
        "id": "7MqZTvnh",
        "title": "Global attractivity and permanence of a stage-structured pest management SI model with time delay and diseased pest impulsive transmission",
        "abstract": "In this paper, we consider a stage-structured pest management SI model with time delay and diseased pests impulsive transmission. We obtain the sufficient conditions of the global attractivity of pest-extinction boundary periodic solution and the permanence of the system. We also prove that all solutions of the system are uniformly ultimately bounded. Our results provide a reliable tactic basis for the practice of pest management.",
        "keywords": [
            "global attractivity",
            "impulsive",
            "permanence",
            "pest-extinction",
            "stage-structured",
            "time delay",
            "pest management"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": ""
            },
            {
                "name": "Xinzhu Meng",
                "org": "College of Science, Shandong University of Science and Technology, Qingdao 266510, People\u2019s Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, People\u2019s Republic of China"
            }
        ],
        "venue": "Advances in Complex Systems",
        "year": 2008
    },
    "dBafoS2N": {
        "id": "dBafoS2N",
        "title": "A delayed ratio-dependent predator-prey system with stage-structured and impulsive stocking on predator",
        "abstract": "In this paper, a delayed ratio-dependent Holling-III predator-prey system with stage-structured and impulsive stocking on predator and continuous harvesting on prey is considered. We obtain sufficient conditions of the global attractivity of prey-extinction periodic solution and the permanence of the system. These results show that the behavior of impulsive stocking on predator plays an important role for the permanence of the system. We also prove that all solutions of the system are uniformly ultimately bounded. Our results show that the biological resource management is effective and reliable. \u00a9 2009 Academie Publications.",
        "keywords": [
            "Globally attractivity",
            "Impulsive effect",
            "Permanence",
            "Ratio-dependent",
            "Stage-structured"
        ],
        "authors": [
            {
                "name": "Zuxiong Li",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology(Dalian University of Technology,Dalian Univ. of Technol.),Dalian,China"
            }
        ],
        "venue": "International Journal of Pure and Applied Mathematics",
        "year": 2009
    },
    "hXXQGKAH": {
        "id": "hXXQGKAH",
        "title": "Corrigendum to \u201cExtinction and permanence of one-prey multi-predators of Holling type II function response system with impulsive biological control\u201d",
        "abstract": "",
        "keywords": [
            "functional response",
            "biological control"
        ],
        "authors": [
            {
                "name": "yongzhen pei",
                "org": "dalian university of technology"
            },
            {
                "name": "lansun chen",
                "org": "dalian university of technology"
            },
            {
                "name": "qingrui zhang",
                "org": "qingdao university of science and technology"
            },
            {
                "name": "changguo li",
                "org": ""
            }
        ],
        "venue": "Journal of Theoretical Biology",
        "year": 2006
    },
    "9INTlNlV": {
        "id": "9INTlNlV",
        "title": "Persistence and global stability for two-species nonautonomous competition Lotka-Volterra patch-system with time delay",
        "abstract": "",
        "keywords": [
            "global asymptotic stability",
            "time delay",
            "two-species nonautonomous competition lotka-volterra",
            "uniform persistence",
            "global stability",
            "diffusion"
        ],
        "authors": [
            {
                "name": "Jingru Zhang",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            },
            {
                "name": "Xiu Dong Chen",
                "org": ""
            }
        ],
        "venue": "Nonlinear Analysis: Theory, Methods & Applications - Special issue on theory and methods, series A",
        "year": 1999
    },
    "3qjDt689": {
        "id": "3qjDt689",
        "title": "The genic mutation on dynamics of a predator-prey system with impulsive effect",
        "abstract": "In this work, we consider a genic mutational predator-prey system with birth pulse and impulsive cutting on prey population at different moments. All the solutions of the investigated system are proved to be uniformly ultimately bounded. The conditions of the globally asymptotically stable predator-extinction boundary periodic solution of the investigated system are obtained. The permanent conditions of the investigated system are also obtained. Finally, numerical simulations are inserted to illustrate the results. Our results present that the genic mutational rate plays an important role on the permanence of the investigated system. Our results also provide reliable tactic basis for the practical biological economics management. \u00a9 2012 Springer Science+Business Media B.V.",
        "keywords": [
            "birth pulse",
            "extinction",
            "genic mutation",
            "impulsive cutting",
            "permanence",
            "predator-prey system"
        ],
        "authors": [
            {
                "name": "Jianjun\u00a0Jiao",
                "org": "Guizhou University(Guizhou University),Guiyang,China"
            },
            {
                "name": "Lansun\u00a0Chen",
                "org": "Academy of Mathematics and System Sciences Chinese Academy of Sciences(Chinese Academy of Sciences,Academy of Mathematics and Systems Science),Beijing,China"
            }
        ],
        "venue": "Nonlinear Dynamics",
        "year": 2012
    },
    "ZpVmB0oh": {
        "id": "ZpVmB0oh",
        "title": "Persistence and stability for a two-species ratio-dependent predator-prey system with time delay in a two-patch environment",
        "abstract": "",
        "keywords": [
            "diffusion model",
            "diffusion"
        ],
        "authors": [
            {
                "name": "rui xu",
                "org": ""
            },
            {
                "name": "lansun chen",
                "org": ""
            }
        ],
        "venue": "Computers & Mathematics With Applications",
        "year": 2000
    },
    "KsnCUOSh": {
        "id": "KsnCUOSh",
        "title": "Periodic solution of a chemostat model with Beddington-DeAnglis uptake function and impulsive state feedback control.",
        "abstract": "In this paper, a chemostat model with Beddington-DeAnglis uptake function and impulsive state feedback control is considered. We obtain sufficient conditions of the global asymptotical stability of the system without impulsive state feedback control. We also obtain that the system with impulsive state feedback control has periodic solution of order one. Sufficient conditions for existence and stability of periodic solution of order one are given. In some cases, it is possible that the system exists periodic solution of order two. Our results show that the control measure is effective and reliable.",
        "keywords": [
            "periodic solution",
            "qualitative analysis",
            "feedback control",
            "globally asymptotical stability",
            "impulsive effect"
        ],
        "authors": [
            {
                "name": "Zuxiong Li",
                "org": ""
            },
            {
                "name": "Tieying Wang",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "Journal of theoretical biology",
        "year": 2009
    },
    "IbYOnU6a": {
        "id": "IbYOnU6a",
        "title": "Comment on \ufffdExistence and stability of periodic solution of a Lotka\ufffdVolterra predator\ufffdprey model wit",
        "abstract": "",
        "keywords": [
            "integrated pest management"
        ],
        "authors": [
            {
                "name": "yuan tian",
                "org": ""
            },
            {
                "name": "kaibiao sun",
                "org": ""
            },
            {
                "name": "lansun chen",
                "org": ""
            }
        ],
        "venue": "Fuel and Energy Abstracts",
        "year": 2010
    },
    "ISVzcdi1": {
        "id": "ISVzcdi1",
        "title": "Global attractivity of nonautonomous stage-structured population models with dispersal and harvest",
        "abstract": "The nonautonomous stage-structured single-species dispersal model with harvesting of mature individuals in an N-patch environment is considered, in which the individual members of the population have a life history that takes them through two stages, immature and mature. By using the theory of monotone and concave operators to functional differential equations, we establish conditions under which this population dynamical system admits a positive periodic solution which attracts all positive solutions.",
        "keywords": [
            "individual member",
            "positive periodic solution",
            "life history",
            "concave operator",
            "positive solution",
            "functional differential equation",
            "mature individual",
            "nonautonomous stage-structured population model",
            "dispersal model",
            "population dynamical system",
            "n-patch environment",
            "global attractivity",
            "dispersal",
            "population dynamic",
            "harvest",
            "monotone",
            "population model"
        ],
        "authors": [
            {
                "name": "Zhonghua Lu",
                "org": "Computer Network Information Center, Chinese Academy of Sciences, Beijing 100080, PR China and School of Statistic, Xi'an University of Finance and Economics, Xi'an 710061, PR China"
            },
            {
                "name": "Xuebin Chi",
                "org": "Computer Network Information Center, Chinese Academy of Sciences, Beijing 100080, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology, Dalian 116024, PR China"
            }
        ],
        "venue": "Journal of Computational and Applied Mathematics",
        "year": 2004
    },
    "0x01q2zQ": {
        "id": "0x01q2zQ",
        "title": "Dynamics of a periodic impulsive switched predator-prey system with hibernation and birth pulse",
        "abstract": "By hibernating, animals can reduce their energy requirements by at least ninety percent and survive for many months while slowly catabolizing body lipid reserves. Hibernation constitutes an effective strategy of animals in order to survive cold environments and limited availability of food. In this work, we investigate a periodic impulsive switched predator-prey system with hibernation and birth pulse. We firstly obtain the conditions of the globally asymptotically stable prey-extinction boundary periodic solution of the investigated system. Secondly, we obtain the permanent conditions of the investigated system. Finally, numerical analysis is presented to illustrate the results. Our results provide reliable tactic basis for the practical biological economics management.",
        "keywords": [
            "hibernation",
            " periodic switched systems",
            " birth pulse",
            " prey-extinction",
            " permanence"
        ],
        "authors": [
            {
                "name": "jianjun jiao",
                "org": "guizhou university of finance and economics"
            },
            {
                "name": "shaohong cai",
                "org": "guizhou university of finance and economics"
            },
            {
                "name": "limei li",
                "org": "guizhou university of finance and economics"
            },
            {
                "name": "lansun chen",
                "org": "institute of mathematics"
            }
        ],
        "venue": "Advances in Difference Equations",
        "year": 2015
    },
    "dOljZSaR": {
        "id": "dOljZSaR",
        "title": "Research Article Harvesting Control for a Stage-Structured Predator-Prey Model with Ivlev's Functional Response and Impulsive Stocking on Prey",
        "abstract": "",
        "keywords": [
            "functional response"
        ],
        "authors": [
            {
                "name": "Kaiyuan Liu",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2007
    },
    "Zy40f0Tq": {
        "id": "Zy40f0Tq",
        "title": "Dynamical analysis on a single population model with state-dependent impulsively unilateral diffusion between two patches",
        "abstract": "Coupling with social progress, traffic development and so on, the natural environment is going into patches. There are differences between population in differential patches. The population living in a patchy environment is affected by the space structures. It is important to depict the dynamical behaviors of the population in the present world. In this work, a state-dependent impulsive differential model, which focuses on impulsively unilateral diffusion between two patches, aims for the simulation of the factual population dynamical behaviors. With the approaches of mathematical analysis, we obtain sufficient conditions of the existence and orbitally asymptotic stability of a periodic solution of the investigated system. Finally, the numerical simulations verify our results. \u00a9 2012 Jiao et al.; licensee Springer.",
        "keywords": [
            "patchy environment",
            "single population",
            "state-dependent impulses",
            "unilateral diffusion"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": "Guizhou College of Finance and Economics(Guizhou College of Finance and Economics),Guiyang,China"
            },
            {
                "name": "Lansun Chen",
                "org": "Academy of Mathematics and System Sciences Chinese Academy of Sciences(Chinese Academy of Sciences,Academy of Mathematics and Systems Science),Beijing,China"
            },
            {
                "name": "Shaohong Cai",
                "org": "Guizhou College of Finance and Economics(Guizhou College of Finance and Economics),Guiyang,China"
            }
        ],
        "venue": "Advances in Difference Equations",
        "year": 2012
    },
    "Th9ydcVF": {
        "id": "Th9ydcVF",
        "title": "A periodic predator-prey-chain system with impulsive perturbation",
        "abstract": "A periodic predator-prey-chain system with impulsive effects is considered. By using the global results of Rabinowitz and standard techniques of bifurcation theory, the existence of its trivial, semi-trivial and nontrivial positive periodic solutions is obtained. It is shown that the nontrivial positive periodic solution for such a system may be bifurcated from an unstable semi-trivial periodic solution. Furthermore, the stability of these periodic solutions is studied.",
        "keywords": [
            "bifurcation theory",
            "periodic solution",
            "standard technique",
            "nontrivial positive periodic solution",
            "impulsive perturbation",
            "unstable semi-trivial periodic solution",
            "global result",
            "periodic predator-prey-chain system",
            "impulsive effect",
            "bifurcation"
        ],
        "authors": [
            {
                "name": "Lingzhen Dong",
                "org": "Department of Mathematics, Taiyuan University of Technology, Taiyuan 030024, China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Mathematics, Dalian University of Technology, Dalian 116023, China"
            }
        ],
        "venue": "Journal of Computational and Applied Mathematics",
        "year": 2009
    },
    "UKZ9iJyz": {
        "id": "UKZ9iJyz",
        "title": "Harmless and Profitless Delays in Discrete Competitive Lotka-Volterra Systems",
        "abstract": "",
        "keywords": [
            "difference equation",
            "discrete system",
            "extinction",
            "density dependence",
            "type system",
            "permanence",
            "interspecific competition",
            "population dynamic"
        ],
        "authors": [
            {
                "name": "Shengqiang Liu",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": ""
            },
            {
                "name": "Ravi P. Agarwal",
                "org": ""
            }
        ],
        "venue": "Applicable Analysis",
        "year": 2004
    },
    "gMWmSMkm": {
        "id": "gMWmSMkm",
        "title": "Research Article On a Periodic Time-Dependent Model of Population Dynamics with Stage Structure and Impulsive Effects",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "kaiyuan liu",
                "org": ""
            },
            {
                "name": "lansun chen",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "n9Qd2C9t": {
        "id": "n9Qd2C9t",
        "title": "Dynamics of a stage-structured predator\u2013prey model with prey impulsively diffusing between two patches",
        "abstract": "In this work, we propose a stage-structured predator\u2013prey model, with prey impulsively diffusing between two patches. Using the discrete dynamical system determined by the stroboscopic map, we obtain a predator-extinction periodic solution. Further, the predator-extinction periodic solution is globally attractive. By the theory on the delay and impulsive differential equation, we prove that the investigated system is permanent. Our results indicate that the discrete time delay has influence to the dynamical behaviors of the investigated system.",
        "keywords": [
            "predator\u2013prey model",
            "permanent",
            "impulsive diffusion",
            "predator-extinction",
            "discrete time"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academia Sinica, Beijing 100080, PR China"
            },
            {
                "name": "Shaohong Cai",
                "org": "School of Mathematics and Statistics, Guizhou Key Laboratory of Economics System Simulation, Guizhou College of Finance and Economics, Guiyang 550004, PR China"
            },
            {
                "name": "Limin Wang",
                "org": "Department of Mathematics and Physics, Dalian Jiaotong University, Dalian 116028, PR China"
            }
        ],
        "venue": "Nonlinear Analysis: Real World Applications",
        "year": 2010
    },
    "9CvpsCk9": {
        "id": "9CvpsCk9",
        "title": "Dynamical behaviors of a delayed chemostat model with impulsive diffusion on nutrients",
        "abstract": "In this paper, a chemostat model with delayed response in growth and impulsive diffusion on nutrients is considered. Using\n the discrete dynamical system determined by the stroboscopic map, we obtain a microorganism-extinction periodic solution.\n Further, it is globally attractive. The permanent condition of the investigated system is also obtained by the theory on impulsive\n delay differential equation. Our results reveal that the impulsive diffusion amount plays an important role on the outcome\n of the chemostat. Finally, the numerical analysis is inserted to illustrate the results.",
        "keywords": [
            "chemostat model \u00b7 delayed response in growth \u00b7 impulsive diffusion \u00b7 extinction \u00b7 permanence",
            "delay differential equation",
            "numerical analysis"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": "School of Mathematics and Statistics, Guizhou Key Laboratory of Economic System Simulation, Guizhou College of Finance and Economics, Guiyang, 550004 China"
            },
            {
                "name": "Shaohong Cai",
                "org": "School of Mathematics and Statistics, Guizhou Key Laboratory of Economic System Simulation, Guizhou College of Finance and Economics, Guiyang, 550004 China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Beijing, 100080 China"
            }
        ],
        "venue": "Journal of Applied Mathematics and Computing",
        "year": 2011
    },
    "JbavgeI4": {
        "id": "JbavgeI4",
        "title": "Dynamical behaviors of the brusselator system with impulsive input",
        "abstract": "Responses of dynamic system to pulse perturbations were investigated theoretically and experimentally. The model used in this\n paper has been proved dissipative by impulsive and dynamic theory. Complex phenomena such as limit cycles, periodic solutions,\n and chaos were numerically demonstrated.",
        "keywords": [
            "Brusselator system",
            "Impulse",
            "Dissipative",
            "Chaos"
        ],
        "authors": [
            {
                "name": "Mingjing Sun",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116024 P.R. China"
            },
            {
                "name": "Yuanshun Tan",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116024 P.R. China"
            },
            {
                "name": "Lansun Chen",
                "org": "Dalian University of Technology Department of Applied Mathematics Dalian 116024 P.R. China"
            }
        ],
        "venue": "Journal of Mathematical Chemistry",
        "year": 2008
    },
    "oibjJDFo": {
        "id": "oibjJDFo",
        "title": "Permanence and extinction of a periodic predator-prey delay system with functional response and stage structure for prey.",
        "abstract": "In this paper, we consider a periodic coefficients predator\u2013prey system with functional response and infinite delay, in which the prey has a history that takes them through two stages, immature and mature. Sufficient conditions which guarantee the permanence and extinction of the system are obtained. Finally, we give an example.",
        "keywords": [
            "stage structure",
            "extinction",
            "permanence",
            "predator\u2013prey system",
            "infinite delay",
            "functional response"
        ],
        "authors": [
            {
                "name": "Hong Zhang",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, DaLian, LiaoNing 116024, PR China"
            },
            {
                "name": "Rongping Zhu",
                "org": "Department of Mathematics, Jiangsu University, ZhenJiang, JiangSu 212013, PR China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2007
    },
    "KvUZgDXQ": {
        "id": "KvUZgDXQ",
        "title": "A delayed epidemic model with stage-structure and pulses for pest management strategy",
        "abstract": "From a biological pest management standpoint, epidemic diseases models have become important tools in control of pest populations. This paper deals with an impulsive delay epidemic disease model with stage-structure and a general form of the incidence rate concerning pest control strategy, in which the pest population is subdivided into three subgroups: pest eggs, susceptible pests, infectious pests that do not attack crops. Using the discrete dynamical system determined by the stroboscopic map, we obtain the exact periodic susceptible pest-eradication solution of the system and observe that the susceptible pest-eradication periodic solution is globally attractive, provided that the amount of infective pests released periodically is larger than some critical value. When the amount of infective pests released is less than another critical value, the system is shown to be permanent, which implies that the trivial susceptible pest-eradication solution loses its attractivity. Our results indicate that besides the release amount of infective pests, the incidence rate, time delay and impulsive period can have great effects on the dynamics of our system.",
        "keywords": [
            "permanence",
            "stage structure",
            "delay",
            "impulsive control",
            "attractivity",
            "pest management",
            "incidence rate",
            "epidemic model",
            "pest control",
            "critical value"
        ],
        "authors": [
            {
                "name": "Hong Zhang",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, DaLian, LiaoNing 116024, PR China"
            },
            {
                "name": "Juan J. Nieto",
                "org": "Departamento de An\u00e1lisis Matem\u00e1tico, Facultad de Matem\u00e1ticas, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain"
            }
        ],
        "venue": "Nonlinear Analysis: Real World Applications",
        "year": 2008
    },
    "abtn79Dp": {
        "id": "abtn79Dp",
        "title": "Impulsive vaccination of SEIR epidemic model with time delay and nonlinear incidence rate",
        "abstract": "In this paper, an SEIR epidemic disease model with time delay and nonlinear incidence rate is studied, and the dynamical behavior of the model under pulse vaccination is analyzed. Using the discrete dynamical system determined by the stroboscopic map, we show that there exists an infection-free periodic solution. Further, we show that the infection-free periodic solution is globally attractive when the period of impulsive effect is less than some critical value. Using a new modelling method, we obtain a sufficient condition for the permanence of the epidemic model with pulse vaccination. We show that time delay, pulse vaccination can bring different effects on the dynamic behavior of the model by numerical analysis. Our results also show the time delay is ''profitless''. The main feature of this paper is to introduce time delay and impulse into the SEIR epidemic model and to give pulse vaccination strategies.",
        "keywords": [
            "global attractivity",
            "permanence",
            "discrete dynamical system",
            "nonlinear incidence rate",
            "dynamic behavior",
            "epidemic model",
            "92d25",
            "pulse vaccination",
            "infection-free periodic solution",
            "periodic solution",
            "seir epidemic disease model",
            "seir epidemic model",
            "time delay",
            "impulsive vaccination",
            "pulse vaccination strategy",
            "34c05",
            "dynamical behavior",
            "critical value",
            "numerical analysis",
            "incidence rate"
        ],
        "authors": [
            {
                "name": "Zhong Zhao",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, PR China and Department of Mathematics, Huanghuai Normal University, Zhumadian 463000, Henan, PR China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, PR China"
            },
            {
                "name": "Xinyu Song",
                "org": "Department of Mathematics, Xinyang Normal University, Xinyang 464000, Henan, PR China"
            }
        ],
        "venue": "Mathematics and Computers in Simulation",
        "year": 2008
    },
    "lp2XwdcK": {
        "id": "lp2XwdcK",
        "title": "An impulsive state feedback control model for releasing white-headed langurs in captive to the wild",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weijian xu",
                "org": ""
            },
            {
                "name": "lansun chen",
                "org": ""
            },
            {
                "name": "shidong chen",
                "org": ""
            },
            {
                "name": "guoping pang",
                "org": ""
            }
        ],
        "venue": "Communications in Nonlinear Science and Numerical Simulation",
        "year": 2016
    },
    "B1DNhJeh": {
        "id": "B1DNhJeh",
        "title": "An appropriate pest management SI model with biological and chemical control concern",
        "abstract": "In this work, we consider an SI model for pest management, and concern about releasing infective pests and spraying pesticides at different fixed moments. We prove that all solutions of (*) d S ( t ) d t = rS ( t ) 1 - S ( t ) + \u03b8 I ( t ) K - \u03b2 S ( t ) I ( t ) , t \u2260 ( n + l - 1 ) \u03c4 , t \u2260 n \u03c4 , d I ( t ) d t = \u03b2 S ( t ) I ( t ) - wI ( t ) , t \u2260 ( n + l - 1 ) \u03c4 , t \u2260 n \u03c4 , \u25b5 S ( t ) = - \u03bc 1 S ( t ) , t = ( n + l - 1 ) \u03c4 , \u25b5 I ( t ) = - \u03bc 2 I ( t ) , t = ( n + l - 1 ) \u03c4 , \u25b5 S ( t ) = 0 , t = n \u03c4 , \u25b5 I ( t ) = \u03bc , t = n \u03c4 , 0 < l < 1 , n = 1 , 2 \u2026 , are uniformly ultimately bounded. The conditions of the globally asymptotic stability pest-extinction boundary periodic solution and the permanence of system (*) are also obtained. Our results provide reliable tactic basis for the practical pest management. Keywords Impulsive Infective Chemical control Pest-extinction 1 Introduction According to the reports of Food and Agriculture Organization, the warfare between man and pests has sustained for thousands of years. With the development of society and progress of sciences, man have adopted some advanced and modern weapons, for example, chemical pesticides, biological pesticides, remote sensing and measure, computers, atomic energy etc., and some brilliant achievements have been obtained. However, the warfare is not over, and will continue. A great deal of pesticides were used to control pests. In all, pesticides are useful because they can quickly kill a significant portion of pest population, and sometimes provide the only feasible method for preventing economic loss. While the pesticide pollution is also recognized as a major health hazard to human beings and beneficial insects. Lengthening the period of spraying pesticides may reduce the cost of pest management. In this paper, A good approach is combining pesticides efficacy with biological control research. The use of bacteria, fungi and viruses is potentially one of the most important approaches in pest control, for example, bacillus thuringiensis, which is available in commercial preparations, is used in the control of a large number of pests [1,3,9] . An advantage of using insect pathogens is that they are safe to man and are usually safe to beneficial insects. There is a vast amount of literatures on the applications of microbial disease to suppress pests [2\u20134,7\u201310] . But there are a few papers on mathematical model of the dynamical of microbial disease in pest control [5,6,11,12,15,16,24] . In this paper, we will introduce additional infective pests, which are obtained in laboratory, into a natural SI system with spaying pesticides for pest control. We shall examine the strategy of combining periodic releasing infective pests with periodic spraying pesticides in a more flexible manner, that is, releasing infectious pest and spraying pesticide are at different fixed moments. Impulsive equations are found in almost every domain of applied science and has been studied in many investigation [13,14,17\u201323] , they generally describe phenomena which are subject to steep or instantaneous changes. Based on the SI model, we should combine releasing pesticides with transmitting infective pests. So the effects on susceptible pests and infective pests are considered as a unified whole. In some case, pesticides can be successfully integrated into pest-management strategy with little harm to the infective pests. This may be accomplished using selecting pesticides and timing the application to avoid periods when the infective pesticides would be exposed or placing the pesticides in a location where the transmitting infective pests wouldn\u2019t contact it. So we suggest an impulsive differential equation to model the process of releasing infective pests and spraying pesticides at different fixed moment. 2 Model formulation The basic SI model is: (2.1) d S ( t ) d t = - \u03b2 S ( t ) I ( t ) , d I ( t ) d t = \u03b2 S ( t ) I ( t ) - wI ( t ) , where S ( t ) denotes the number of susceptible insects and I ( t ) denotes the number of infective insects at time t , respectively. \u03b2 > 0 is called the transmission coefficient. w > 0 is called the death coefficient of I ( t ). In the models which are investigated in this paper, we assume that all newborns are susceptible, and the basic model considered in [12] is following epidemic model with a control variable: (2.2) d S ( t ) d t = - \u03b2 S ( t ) I ( t ) , d I ( t ) d t = \u03b2 S ( t ) I ( t ) - wI ( t ) + u ( t ) , where S ( t ) denotes the number of susceptible insects and I ( t ) denotes the number of infective insects at time t , respectively. \u03b2 > 0 is called the transmission coefficient, w > 0 is called the death coefficient of I ( t ). The control variable u ( t ) denotes the rate of pests infected which is brought up in the laboratory, and there are some other conditions for system (2.2) . But we consider that the variable u ( t ) is difficult to control in practice, while the susceptible pests will not go extinction. So we develop (2.2) by introducing releasing the infective pests and spaying pesticides at different fixed moments, that is, we consider the following impulsive differential equation with different fixed moments: (2.3) d S ( t ) d t = rS ( t ) ( 1 - S ( t ) + \u03b8 I ( t ) K ) - \u03b2 S ( t ) I ( t ) , t \u2260 ( n + l - 1 ) \u03c4 , t \u2260 n \u03c4 , d I ( t ) d t = \u03b2 S ( t ) I ( t ) - wI ( t ) , t \u2260 ( n + l - 1 ) \u03c4 , t \u2260 n \u03c4 , \u25b5 S ( t ) = - \u03bc 1 S ( t ) , t = ( n + l - 1 ) \u03c4 , \u25b5 I ( t ) = - \u03bc 2 I ( t ) , t = ( n + l - 1 ) \u03c4 , \u25b5 S ( t ) = 0 , t = n \u03c4 , \u25b5 I ( t ) = \u03bc , t = n \u03c4 , 0 < l < 1 , n = 1 , 2 , \u2026 , where S ( t ) denotes the number of susceptible insects and I ( t ) denotes the number of infective insects at time t , respectively. \u03b2 > 0 is called the transmission coefficient. w > 0 is called the death coefficient of I ( t ). r > 0 is called the intrinsic growth rate of pests. K > 0 is the pests capacity of environment. \u25b5 I ( t ) = I ( t + ) - I ( t ) , 0 < \u03b8 < 1 , 0 < l < 1 . \u03bc \u2a7e 0 is the releasing amount of infective pests at t = n \u03c4 , n \u2208 Z + . 1 > \u03bc 1 \u2a7e 0 , 1 > \u03bc 2 \u2a7e 0 respectively represents the portion of susceptible and infective pests which due to spraying pesticides at t = n \u03c4 , n \u2208 Z + and Z + = { 1 , 2 , \u2026 } . \u03c4 is the period of the impulsive effect. We will prove that system (2.3) has a susceptible pests extinction boundary periodic solution which is globally asymptotically stable. Due to the disease, all the pests will be the infectious, then the infectious will eventually be death, that is, we can use a combination of biological and chemical tactics to eradicates pests. So we call susceptible pests extinction as pest-extinction. In this paper, we always assume that the damages of the infectious pests are far less than that of the susceptible pests. 3 Analyzing model (2.3) Before discussing main results, we will give some definitions, notations and lemmas. Let R + = [ 0 , \u221e ) , R + 2 = { x \u2208 R 2 : x > 0 } . Denote f = ( f 1 , f 2 ) the map defined by the right hand of system (2.3) . Let V : R + \u00d7 R + 2 \u2192 R + , then V is said to belong to class V 0 , if (i) V is continuous in ( ( n - 1 ) \u03c4 , ( n + l - 1 ) \u03c4 ] \u00d7 R + 2 and ( ( n + l - 1 ) \u03c4 , n \u03c4 ] \u00d7 R + 2 , for each x \u2208 R + 2 , n \u2208 Z + , lim ( t , y ) \u2192 ( ( n + l - 1 ) \u03c4 + , x ) V ( t , y ) = V ( ( n + l - 1 ) \u03c4 + , x ) and lim ( t , y ) \u2192 ( n \u03c4 + , x ) V ( t , y ) = V ( n \u03c4 + , x ) exists. (ii) V is locally Lipschitzian in x . Definition\u00a01 V \u2208 V 0 , then for ( t , x ) \u2208 ( ( n - 1 ) \u03c4 , ( n + l - 1 ) \u03c4 ] \u00d7 R + 2 and ( ( n + l - 1 ) \u03c4 , n \u03c4 ] \u00d7 R + 2 , the upper right derivative of V ( t , x ) with respect to the impulsive differential system (2.3) is defined as: D + V ( t , x ) = lim h \u2192 0 sup 1 h [ V ( t + h , x + hf ( t , x ) ) - V ( t , x ) ) ] . The solution of (2.3) , denote by x ( t ) = ( S ( t ) , I ( t ) ) T , is a piecewise continuous function x : R + \u2192 R + 2 , x ( t ) is continuous on ( ( n - 1 ) \u03c4 , ( n + l - 1 ) \u03c4 ] \u00d7 R + 2 and ( ( n + l - 1 ) \u03c4 , n \u03c4 ] \u00d7 R + 2 ( n \u2208 Z + , 0 \u2a7d l \u2a7d 1 ) . Obviously, the global existence and uniqueness of solutions of (2.3) is guaranteed by the smoothness properties of f , which denotes the mapping defined by right-side of system (2.3) (see Lakshmikantham [13] ). Before we have the the main results. we need give some lemmas which will be used in the next. Since ( S \u2032( t ) = 0 whenever S ( t ) = 0, I \u2032( t ) = 0 whenever I ( t ) = 0 , t = ( n + l - 1 ) \u03c4 , S ( ( n + l - 1 ) \u03c4 + ) = ( 1 - \u03bc 1 ) S ( ( n + l - 1 ) \u03c4 ) , I ( ( n + l - 1 ) \u03c4 + ) = ( 1 - \u03bc 2 ) I ( ( n + l - 1 ) \u03c4 ) ( 0 \u2a7d \u03bc 1 \u2a7d 1 , 0 \u2a7d \u03bc 2 \u2a7d 1 ) and t = n\u03c4 , I ( n \u03c4 + ) = I ( n \u03c4 ) + \u03bc , \u03bc \u2a7e 0 , So we easily have Lemma\u00a01 Suppose x(t) is a solution of ( 2.3 ) with x(0 + ) \u2a7e 0, then x(t) \u2a7e 0 for t \u2a7e 0. and further x(t) > 0 t \u2a7e 0 for x(0 + ) > 0. Now, we show that all solutions of ( 2.3 ) are uniformly ultimately bounded. Lemma\u00a02 There exists a constant M > 0 such that S ( t ) \u2a7d M , I ( t ) \u2a7d M for each solution ( S ( t ) , I ( t ) ) of ( 2.3 ) with all t large enough. Proof Define V ( t ) = S ( t ) + I ( t ), then t \u2260 n\u03c4 , we have D + V ( t ) + wV ( t ) = ( r + w ) S ( t ) - rS 2 ( t ) K - r \u03b8 S ( t ) I ( t ) K \u2a7d ( r + w ) S ( t ) - rS 2 ( t ) K \u2a7d M 0 , where M 0 = K ( r + w ) 2 4 r , when t = ( n + l - 1 ) \u03c4 , V ( ( n + l - 1 ) \u03c4 + ) = ( 1 - \u03bc 1 ) S ( ( n + l - 1 ) \u03c4 ) + ( 1 - \u03bc 2 ) I ( ( n + l - 1 ) \u03c4 ) \u2a7d S ( ( n + l - 1 ) \u03c4 ) + I ( ( n + l - 1 ) \u03c4 ) = V ( n \u03c4 ) , t = n \u03c4 , V ( n \u03c4 + ) = S ( n \u03c4 ) + I ( n \u03c4 ) + \u03bc = V ( n \u03c4 ) + \u03bc . From (Lemma 2.2 [13] , page 23), for t \u2208 ( ( n - 1 ) \u03c4 , ( n + l - 1 ) \u03c4 ] and ( ( n + l - 1 ) \u03c4 , n \u03c4 ] , we have V ( t ) \u2a7d V ( 0 + ) e - wt + M 0 w ( 1 - e - w \u03c4 ) + \u03bc e - w ( t - \u03c4 ) 1 - e w \u03c4 + \u03bc e - w \u03c4 e w \u03c4 - 1 \u2192 M 0 w + \u03bc e w \u03c4 e w \u03c4 - 1 , as t \u2192 \u221e . So V ( t ) is uniformly ultimately bounded. Hence, by the definition of V ( t ), there exists a constant M > 0 such that S ( t ) \u2a7d M , I ( t ) \u2a7d M for t large enough. The proof is complete. If S ( t ) = 0, we have the following subsystem of system (2.3): (3.1) d I ( t ) d t = - wI ( t ) , t \u2260 ( n + l - 1 ) \u03c4 , t \u2260 n \u03c4 , I ( n \u03c4 + ) = ( 1 - \u03bc 2 ) I ( n \u03c4 ) , t = ( n + l - 1 ) \u03c4 , n = 1 , 2 , \u2026 , I ( n \u03c4 + ) = I ( n \u03c4 ) + \u03bc , t = n \u03c4 , n = 1 , 2 , \u2026 , I ( 0 + ) = I ( 0 ) > 0 , Obviously (3.2) I ( t ) \u223c = \u03bc e - w ( t - ( n - 1 ) \u03c4 ) 1 - ( 1 - \u03bc 2 ) e - w \u03c4 , t \u2208 ( ( n - 1 ) \u03c4 , ( n + l - 1 ) \u03c4 ] , \u03bc ( 1 - \u03bc 2 ) e - w ( t - ( n - 1 ) \u03c4 ) 1 - ( 1 - \u03bc 2 ) e - w \u03c4 , t \u2208 ( ( n + l - 1 ) \u03c4 , n \u03c4 ] , then, I ( 0 + ) \u223c = I ( n \u03c4 + ) \u223c = \u03bc 1 - ( 1 - \u03bc 2 ) e - w \u03c4 , I ( l \u03c4 + ) \u223c = \u03bc ( 1 - \u03bc 2 ) e - wl \u03c4 1 - ( 1 - \u03bc 2 ) e - w \u03c4 is a positive periodic solution of (3.2) . Since the solution of (3.2) is: (3.3) I ( t ) = ( 1 - \u03bc 2 ) n - 1 I ( 0 + ) - \u03bc 1 - ( 1 - \u03bc 2 ) e - w \u03c4 e - wt + I ( t ) \u223c , t \u2208 ( ( n - 1 ) \u03c4 , ( n + l - 1 ) \u03c4 , ( 1 - \u03bc 2 ) n I ( 0 + ) - \u03bc 1 - ( 1 - \u03bc 2 ) e - w \u03c4 e - wt + I ( t ) \u223c , t \u2208 ( ( n + l - 1 ) \u03c4 , n \u03c4 . So we can easily derive. \u25a1 Lemma\u00a03 System ( 3.2 ) has a positive periodic solution I ( t ) \u223c . For every solution I(t) of system ( 3.2 ) , we have I ( t ) \u2192 I ( t ) \u223c as t \u2192 \u221e . From above discussion, we know that ( 2.3 ) has a pest-extinction periodic solution ( 0 , I ( t ) \u223c ) . Then we have following theorem. Theorem\u00a01 Let ( S ( t ) , I ( t ) ) be any solution of ( 2.3 ) , If ln 1 1 - \u03bc 1 > r \u03c4 - \u03bc w r \u03b8 K + \u03b2 1 - \u03bc 2 e - wl \u03c4 - ( 1 - \u03bc 2 ) e - w \u03c4 1 - ( 1 - \u03bc 2 ) e - w \u03c4 , holds, then pest-extinction periodic solution ( 0 , I ( t ) \u223c ) of ( 2.3 ) is globally asymptotically stable. Proof First, we prove the local stability. Define s ( t ) = S ( t ) , i ( t ) = I ( t ) - I ( t ) \u223c , we have the following linearly similar system of system (2.3): d s ( t ) d t d i ( t ) d t = r - r \u03b8 K + \u03b2 I ( t ) \u223c 0 \u03b2 I ( t ) \u223c - w s ( t ) i ( t ) . It is easy to to obtain the fundamental solution matrix: \u03a6 ( t ) = exp \u222b 0 t r - r \u03b8 K + \u03b2 I ( t ) \u223c d s 0 \u2217 exp ( - wt ) . There is no need to calculate the exact form of (\u2217) as it is not required in the analysis that follows. The linearization of the third and fourth equations of (2.3) is: s ( ( n + l - 1 ) \u03c4 + ) i ( ( n + l - 1 ) \u03c4 + ) = 1 - \u03bc 1 0 0 1 - \u03bc 2 s ( ( n + l - 1 ) \u03c4 ) i ( ( n + l - 1 ) \u03c4 ) . The linearization of the fifth and sixth equations of (2.3) is: s ( n \u03c4 + ) i ( n \u03c4 + ) = 1 0 0 1 s ( n \u03c4 ) i ( n \u03c4 ) . The stability of the periodic solution ( 0 , I ( t ) \u223c ) is determined by the eigenvalues of M = 1 - \u03bc 1 0 0 1 - \u03bc 2 1 0 0 1 \u03d5 ( \u03c4 ) , which are \u03bb 1 = ( 1 - \u03bc 2 ) exp ( - w \u03c4 ) < 1 , \u03bb 2 = ( 1 - \u03bc 1 ) exp \u222b 0 \u03c4 r - r \u03b8 K + \u03b2 I ( t ) \u223c d s . According to the Floquet theory [14] , if \u2223 \u03bb 2 \u2223 < 1, i.e. ln 1 1 - \u03bc 1 > r \u03c4 - \u03bc w r \u03b8 K + \u03b2 1 - \u03bc 2 e - wl \u03c4 - ( 1 - \u03bc 2 ) e - w \u03c4 1 - ( 1 - \u03bc 2 ) e - w \u03c4 , holds, then ( 0 , I ( t ) \u223c ) is locally stable. The following work is to prove the global attraction, choose a \u03b5 > 0 such that \u03c1 = ( 1 - \u03bc 1 ) exp \u222b 0 \u03c4 r - r \u03b8 K + \u03b2 ( I ( t ) \u223c - \u03b5 ) d t < 1 . From the second equation of (2.3) , we notice that d I ( t ) d t \u2a7e - wI ( t ) , so we consider following impulsive differential equation: (3.4) d y ( t ) d t = - wy ( t ) , t \u2260 ( n + l - 1 ) \u03c4 , y ( t + ) = ( 1 - \u03bc 2 ) y ( t ) + \u03bc , t = ( n + l - 1 ) \u03c4 , y ( 0 + ) = I ( 0 + ) . From Lemma 2 and comparison theorem of impulsive equation (see theorem 3.1.1 in [13] ), we have I ( t ) \u2a7e y ( t ) and y ( t ) \u2192 I ( t ) \u223c as t \u2192 \u221e, that is (3.5) I ( t ) \u2a7e y ( t ) \u2a7e I ( t ) \u223c - \u03b5 , for all t large enough, for convenience, we may assume (3.5) hold for all t \u2a7e 0. From (2.3) and (3.6) , we get (3.6) d S ( t ) d t \u2a7d rS ( t ) ( 1 - ( r \u03b8 K + \u03b2 ) ( I ( t ) \u223c - \u03b5 ) ) , t \u2260 ( n + l - 1 ) \u03c4 , S ( n \u03c4 + ) = ( 1 - \u03bc 1 ) S ( n \u03c4 ) , t = ( n + l - 1 ) \u03c4 , n = 1 , 2 , \u2026 , so S ( ( n + l ) \u03c4 ) \u2a7d S ( ( n + l - 1 ) \u03c4 ) ( 1 - \u03bc 1 ) exp \u222b ( n + l - 1 ) \u03c4 ( n + l ) \u03c4 r - r \u03b8 K + \u03b2 ( I ( t ) \u223c - \u03b5 ) d s , hence S ( ( n + l ) \u03c4 ) \u2a7d S ( l \u03c4 + ) \u03c1 n and S ( ( n + l ) \u03c4 ) \u2192 0 as n \u2192 \u221e, therefore S ( t ) \u2192 0 as t \u2192 \u221e. Since 0 < S ( t ) \u2a7d S ( ( n + l - 1 ) \u03c4 ) ( 1 - \u03bc 1 ) e r \u03c4 for ( n + l - 1 ) \u03c4 < t \u2a7d ( n + l ) \u03c4 . Next we prove that I ( t ) \u2192 I ( t ) \u223c as t \u2192 \u221e. For 0 < \u03b5 \u2a7d w \u03b2 , there must exist a t 0 > 0 such that 0 < S ( t ) < \u03b5 for all t \u2a7e t 0 . Without loss of generality, we assume that 0 < S ( t ) < \u03b5 for all t \u2a7e 0, then, for system (2.3) , we have (3.7) - wI ( t ) \u2a7d d I ( t ) d t \u2a7d ( - w + \u03b2 \u03b5 ) I ( t ) , then, we have z 1 ( t ) \u2a7d I ( t ) \u2a7d z 2 ( t ) , and z 1 ( t ) \u2192 I ( t ) \u223c , z 2 ( t ) \u2192 I ( t ) \u223c , as t \u2192 \u221e. While z 1 ( t ) and z 2 ( t ) are the solutions of (3.8) d z 1 ( t ) d t = - wz 1 ( t ) , t \u2260 ( n + l - 1 ) \u03c4 , t \u2260 n \u03c4 , z 1 ( t + ) = ( 1 - \u03bc 2 ) z 1 ( t ) , t = ( n + l - 1 ) \u03c4 , z 1 ( t + ) = z 1 ( t ) + \u03bc , t = n \u03c4 , z 1 ( 0 + ) = I ( 0 + ) , and (3.9) d z 2 ( t ) d t = ( - w + \u03b2 \u03b5 ) z 2 ( t ) , t \u2260 ( n + l - 1 ) \u03c4 , t \u2260 n \u03c4 , z 2 ( t + ) = ( 1 - \u03bc 2 ) z 2 ( t ) , t = ( n + l - 1 ) \u03c4 , z 2 ( t + ) = z 2 ( t ) + \u03bc , t = n \u03c4 , z 2 ( 0 + ) = I ( 0 + ) , respectively, (3.10) z 2 ( t ) \u223c = \u03bc e ( - w + \u03b2 \u03b5 ) ( t - ( n - 1 ) \u03c4 ) 1 - ( 1 - \u03bc 2 ) e ( - w + \u03b2 \u03b5 ) \u03c4 , t \u2208 ( ( n - 1 ) \u03c4 , ( n + l - 1 ) \u03c4 ] , \u03bc ( 1 - \u03bc 2 ) e ( - w + \u03b2 \u03b5 ) ( t - ( n - 1 ) \u03c4 ) 1 - ( 1 - \u03bc 2 ) e ( - w + \u03b2 \u03b5 ) \u03c4 , t \u2208 ( ( n + l - 1 ) \u03c4 , n \u03c4 ] . Therefore, for any \u03b5 1 > 0. there exists a t 1 , t > t 1 such that z 1 ( t ) \u223c - \u03b5 1 < I ( t ) < z 2 ( t ) \u223c + \u03b5 . Let \u03b5 \u2192 0, so we have I ( t ) \u223c - \u03b5 1 < I ( t ) < I ( t ) \u223c + \u03b5 1 , for t large enough, which implies I ( t ) \u2192 I ( t ) \u223c as t \u2192 \u221e. This completes the proof. \u25a1 The next work is to investigate the permanence of system (2.3) . Before starting this work, we should give the following definition. Definition\u00a02 System (2.3) is said to be permanent if there are constants m , M > 0 (independent of initial value) and a finite time T 0 such that for all solutions ( S ( t ), I ( t )) with all initial values S ( 0 + ) > 0 , I ( 0 + ) > 0 , m \u2a7d S ( t ) \u2a7d M , m \u2a7d I ( t ) \u2a7d M holds for all t \u2a7e T 0 . Here T 0 may depend on the initial values ( S ( 0 + ) , ( I ( 0 + ) ) . Theorem\u00a02 Let ( S ( t ) , I ( t ) ) be any solution of ( 2.3 ) , If ln 1 1 - \u03bc 1 < r \u03c4 - \u03bc w r \u03b8 K + \u03b2 1 - \u03bc 2 e - wl \u03c4 - ( 1 - \u03bc 2 ) e - w \u03c4 1 - ( 1 - \u03bc 2 ) e - w \u03c4 , holds, then, system ( 2.3 ) is permanent. Proof Let ( S ( t ) , I ( t ) ) be a solution of (2.3) with S ( 0 ) > 0 , I ( 0 ) > 0 . By Lemma 3 , we have proved there exists a constant M > 0 such that S ( t ) \u2a7d M , I ( t ) \u2a7d M for t large enough. We may assume S ( t ) \u2a7d M , I ( t ) \u2a7d M and M > r \u03b2 for t \u2a7e 0. From (3.6) , we know I ( t ) > I ( t ) \u223c - \u03b5 2 for all t large enough, and \u03b5 2 > 0. So I ( t ) \u2a7e \u03bc ( 1 - \u03bc 2 ) exp ( - w \u03c4 ) 1 - exp ( - w \u03c4 ) - \u03b5 = m 2 for t large enough. Thus, we only need to find m 1 > 0 such that S ( t ) \u2a7e m 1 for t large enough. We will do it in the following two steps. Step 1 . By the condition of Theorem 2 , we can select m 3 > 0, \u03b5 1 > 0 small enough such that 0 < m 3 < w \u03b2 , \u03b4 = \u03b2 m 3 M < w , and \u03c3 = r \u03c4 - r K m 3 \u03c4 - r \u03b8 K + \u03b2 \u03b5 1 \u03c4 \u03bc w - \u03b2 m 3 r \u03b8 K + \u03b2 1 - \u03bc 2 e ( - w + \u03b2 m 3 ) l \u03c4 - ( 1 - \u03bc 2 ) e ( - w + \u03b2 m 3 ) \u03c4 1 - ( 1 - \u03bc 2 ) e ( - w + \u03b2 m 3 ) \u03c4 > 0 . We will prove that S ( t ) < m 3 can not hold for t \u2a7e 0. Otherwise, (3.11) d I ( t ) d t \u2a7d ( - w + \u03b2 m 3 ) I ( t ) , t \u2260 ( n + l - 1 ) \u03c4 , t \u2260 n \u03c4 , I ( t + ) = ( 1 - \u03bc 2 ) I ( t ) , t = ( n + l - 1 ) \u03c4 , I ( t + ) = I ( t ) + \u03bc , t = n \u03c4 . By Lemmas 3 , we have I ( t ) \u2a7d z ( t ) and z ( t ) \u2192 z ( t ) \u00af , t \u2192 \u221e , where z ( t ) is the solution of (3.12) d z ( t ) d t = ( - w + \u03b2 m 3 ) z ( t ) , t \u2260 ( n + l - 1 ) \u03c4 , t \u2260 n \u03c4 , I ( t + ) = ( 1 - \u03bc 2 ) I ( t ) , t = ( n + l - 1 ) \u03c4 , I ( t + ) = I ( t ) + \u03bc , t = n \u03c4 , z ( 0 + ) = I ( 0 + ) , and (3.13) z ( t ) \u00af = \u03bc e ( - w + \u03b2 m 3 ) ( t - ( n - 1 ) \u03c4 ) 1 - ( 1 - \u03bc 2 ) e ( - w + \u03b2 m 3 ) \u03c4 , t \u2208 ( ( n - 1 ) \u03c4 , ( n + l - 1 ) \u03c4 ] , \u03bc ( 1 - \u03bc 2 ) e ( - w + \u03b2 m 3 ) ( t - ( n - 1 ) \u03c4 ) 1 - ( 1 - \u03bc 2 ) e ( - w + \u03b2 m 3 ) \u03c4 , t \u2208 ( ( n + l - 1 ) \u03c4 , n \u03c4 ] . Therefore, there exists a T 1 > 0 such that I ( t ) \u2a7d z ( t ) \u2a7d z ( t ) \u00af + \u03b5 1 , and (3.14) d S ( t ) d t \u2a7e S ( t ) ( r - r K m 3 - r \u03b8 K + \u03b2 ( z ( t ) \u00af + \u03b5 1 ) ) , t \u2260 ( n + l - 1 ) \u03c4 , S ( t + ) = ( 1 - \u03bc 1 ) S ( t ) , t = ( n + l - 1 ) \u03c4 , n = 1 , 2 , \u2026 , for t \u2a7e T 1 . Let N 1 \u2208 N and N 1 \u03c4 > T 1 , integrating (3.14) on ( ( n + l - 1 ) \u03c4 , ( n + l ) \u03c4 ) , n \u2a7e N 1 , we have S ( ( n + l ) \u03c4 ) \u2a7e ( 1 - \u03bc 1 ) S ( ( n + l - 1 ) \u03c4 ) exp \u222b ( n + l - 1 ) \u03c4 ( n + l ) \u03c4 r - r K m 3 - r \u03b8 K + \u03b2 ( z ( t ) \u00af + \u03b5 1 ) d t = ( 1 - \u03bc 1 ) S ( ( n + l - 1 ) \u03c4 ) e \u03c3 , then, S ( ( N 1 + k + l ) \u03c4 ) \u2a7e ( 1 - \u03bc 1 ) k S ( ( N 1 + l ) \u03c4 ) e k \u03c3 \u2192 \u221e , as k \u2192 \u221e, which is a contradiction to the boundedness of S ( t ). Hence there exists a t 1 > 0 such that S ( t ) \u2a7e m 3 . Step 2 . If S ( t ) \u2a7e m 3 for t \u2a7e t 1 , then our aim is obtained. Hence, we only need to consider those solutions which leave region R = { ( S ( t ) , I ( t ) ) \u2208 R + 2 : S ( t ) < m 3 } and reenter it again. Let t \u2217 = inf t \u2a7e t 1 { S ( t ) < m 3 } , there are two possible cases for t \u2217 . Case 1. t \u2217 = ( n + l - 1 ) \u03c4 , n 1 \u2208 Z + , then S ( t ) \u2a7e m 3 for t \u2208 [ t 1 , t \u2217 ) and S ( t \u2217 ) = m 3 , and ( 1 - \u03bc 1 ) m 3 \u2a7d S ( t \u2217 + ) = ( 1 - \u03bc 1 ) S ( t \u2217 ) \u2a7d m 3 . Select n 2 , n 3 \u2208 N , such that ( n 2 - 1 ) \u03c4 > T 2 = ln \u03b5 1 M + \u03bc - w + \u03b2 m 3 , ( 1 - \u03bc 1 ) n 2 e n 3 \u03c3 e n 2 \u03c3 1 \u03c4 > ( 1 - \u03bc 1 ) n 2 e n 3 \u03c3 e ( n 2 + 1 ) \u03c3 1 \u03c4 > 1 , where \u03c3 1 = r - rm 3 K - \u03b8 K r - r \u03b8 K + \u03b2 M < 0 , let T = n 1 \u03c4 + n 2 \u03c4 . We claim that there must be a t 2 \u2208 [ t \u2217 , t \u2217 + T ] such that S ( t 2 ) > m 3 , otherwise, consider (3.13) with z ( t \u2217 + ) = I ( t \u2217 + ) . We have (3.15) z ( t ) = ( 1 - \u03bc 2 ) n - ( n 1 + 1 ) z ( n 1 + ) - \u03bc 1 - ( 1 - \u03bc 2 ) e ( - w + \u03b2 m 3 ) \u03c4 e ( - w + \u03b2 m 3 ) t + z ( t ) \u00af , t \u2208 ( ( n - 1 ) \u03c4 , ( n + l - 1 ) \u03c4 ] , ( 1 - \u03bc 2 ) n - n 1 I ( 0 + ) - \u03bc 1 - ( 1 - \u03bc 2 ) e ( - w + \u03b2 m 3 ) \u03c4 e ( - w + \u03b2 m 3 ) t + z ( t ) \u00af , t \u2208 ( ( n + l - 1 ) \u03c4 , n \u03c4 ] , and n 1 + 1 \u2a7d n \u2a7d n 2 + n 3 , then | z ( t ) - z ( t ) \u00af | < ( \u03bc + M ) e ( - w + \u03b2 m 3 ) ( t - n 1 \u03c4 ) < \u03b5 1 , and I ( t ) \u2a7d z ( t ) \u2a7d z ( t ) \u00af + \u03b5 1 , ( n 1 + n 2 - 1 ) \u03c4 \u2a7d t \u2a7d t \u2217 + T , which implies (3.14) holds for t \u2217 + n 2 \u03c4 \u2a7d t \u2a7d t \u2217 + T . As in step 1 , we have S ( t \u2217 + T ) \u2a7e S ( t \u2217 + n 2 ) \u03c4 ) e n 3 \u03c3 . The first equation of (2.3) gives (3.16) d S ( t ) d t \u2a7e S ( t ) r - r K m 3 - r \u03b8 K + \u03b2 M = \u03c3 1 S ( t ) , t \u2260 ( n + l - 1 ) \u03c4 , S ( t + ) = ( 1 - \u03bc 1 ) S ( t ) , t = ( n + l - 1 ) \u03c4 , Integrating (3.16) on [ t \u2217 , t \u2217 + n 2 \u03c4 ] , we have S ( t \u2217 + n 2 \u03c4 ) \u2a7e m 3 ( 1 - \u03bc 1 ) n 2 e \u03c3 1 n 2 \u03c4 , thus we have S ( t \u2217 + T ) \u2a7e m 3 ( 1 - \u03bc 1 ) n 2 e \u03c3 1 n 2 \u03c4 e n 3 \u03c3 > m 3 , which is a contradiction. Let t \u00af = inf t \u2a7e t \u2217 { S ( t ) \u2a7e m 3 } , thus S ( t \u00af ) \u2a7e m 3 for t \u2208 [ t \u2217 , t \u00af ] , we have S ( t ) \u2a7e ( 1 - \u03bc 1 ) n 2 + n 3 S ( t \u2217 ) e \u03c3 1 ( t - t \u2217 ) \u2a7e ( 1 - \u03bc 1 ) n 2 + n 3 m 3 e \u03c3 1 ( n 2 + n 3 ) = m 1 for t \u2a7e t \u00af . So we have S ( t ) \u2a7e m 1 . The same arguments can be continued since S ( t \u00af ) \u2a7e m 3 . Hence S ( t ) \u2a7e m 1 for all t \u2a7e t \u00af . Case 2. t \u2260 ( n + l - 1 ) \u03c4 , n \u2208 Z + , then S ( t ) \u2a7e m 3 for t \u2208 [ t 1 , t \u2217 ) , and S ( t \u2217 ) = m 3 . Suppose t \u2217 \u2208 ( ( n 1 \u2032 + l - 1 ) \u03c4 , ( n 1 \u2032 + l ) \u03c4 ) , ( t \u2208 Z + ) , then there are two possible cases for t \u2208 ( t \u2217 , ( n 1 \u2032 + l ) \u03c4 ) . Case 2(a). S ( t ) \u2a7d m 3 for all t \u2208 ( t \u2217 , ( n 1 \u2032 ) \u03c4 ) . Similar to case 1., we can prove that there must be a t 2 \u2032 \u2208 [ ( n 1 \u2032 + l ) \u03c4 , ( n 1 \u2032 + l ) \u03c4 + T ] such that S ( t 2 \u2032 ) > m 3 . Here we omit it. Let t \u00af = inf t > t \u2217 { S ( t ) > m 3 } , then S ( t ) \u2a7d m 3 for t \u2208 ( t \u2217 , t \u00af ) and S ( t \u00af ) = m 3 . For t \u2208 ( t \u2217 , t \u00af ) , we have S ( t ) \u2a7e m 3 ( 1 - \u03bc 1 ) n 2 + n 3 e ( n 2 + n 3 + 1 ) \u03c3 1 \u03c4 . Let m 1 = m 3 ( 1 - \u03bc 1 ) n 2 + n 3 e ( n 2 + n 3 + 1 ) \u03c3 1 \u03c4 < m 1 \u2032 , so S ( t ) \u2a7e m 1 for t \u2208 ( t \u2217 , t \u00af ) . For t > t \u00af , the same arguments can be continued since S ( t ) \u2a7e m 1 . Case 2(b). There exists a t \u2208 ( t \u2217 , ( n 1 \u2032 ) \u03c4 ) such that S ( t ) > m 3 . Let t \u02c6 = inf t > t \u2217 { S ( t ) > m 3 } , then S ( t ) \u2a7d m 3 for t \u2208 ( t \u2217 , t \u02c6 ) and S ( t \u02c6 ) = m 3 . For t \u2208 ( t \u2217 , t \u02c6 ) , (3.17) holds true, integrating (3.17) on ( t \u2217 , t \u02c6 ) , we derive S ( t ) \u2a7e S ( t \u2217 ) e \u03c3 1 ( t \u02c6 - t \u2217 ) \u2a7e m 3 e \u03c3 1 \u03c4 > m 1 . Since S ( t \u02c6 ) \u2a7e m 3 for t > t \u02c6 , the same arguments can be continued. Hence S ( t ) \u2a7e m 3 for t \u2a7e t 1 . This completes the proof. \u25a1 Remark\u00a03.1 Let F ( \u03c4 ) = r \u03c4 - \u03bc w r \u03b8 K + \u03b2 1 - \u03bc 2 e - wl \u03c4 - ( 1 - \u03bc 2 ) e - w \u03c4 1 - ( 1 - \u03bc 2 ) e - w \u03c4 - ln 1 1 - \u03bc 1 , we can easily know F ( 0 ) = - ln 1 1 - \u03bc 1 < 0 , F ( \u03c4 ) \u2192 \u221e as \u03c4 \u2192 \u221e, and F \u2033 ( \u03c4 ) > 0 . So F ( \u03c4 ) = 0 has a unique positive root, denoted by \u03c4 max . From Theorem 1 and 2 , we know \u03c4 max is a threshold. If \u03c4 < \u03c4 max , the pest-extinction solution ( 0 , I ( t ) \u223c ) of system (2.3) is globally asymptotically stable. If \u03c4 > \u03c4 max the system (2.3) is permanent. Remark\u00a03.2 If \u03bc = 0, i.e. there are no periodic releasing infective pests. Thus, we can easily obtain that \u03c4 1 = 1 r ln 1 1 - \u03bc 1 is the threshold. Obviously, \u03c4 max > \u03c4 1 , i.e. impulsively releasing infective pests may lengthen the period of spraying pesticides, therefore, reduce cost of pests control. 4 Discussion In this paper, according to the fact, an SI model with transmitting infective pests and spraying pesticides at different fixed moment is proposed and investigated. We analyze that the pest-extinction periodic solution of such system is globally asymptotic stability, and obtained the condition for the permanence of system (2.3) . There are some interesting problems: how to optimalize the amount of spraying pesticides? How to do with the determining time of impulsive releasing infective pests depending on the state of insect pest? How the impulsive releasing infective pest affect the dynamics of the system? In the real world, For the insect pest is with seasonal damages, Should impulsive releasing infective be considered on finite interval? We will continue to study these problems in the future. Acknowledgement This work was supported by National Natural Science Foundation of China (10471117) and the Emphasis Subject Fund of Guizhou College of Finance and Economic. References [1] L.A. Falcon Use of Bacteria for Microbial Control of Insects 1971 Academic Press New York, NY [2] H.D. Burges N.W. Hussey Microbial Control of Insects and Mites 1971 Academic Press New York, NY pp. 67\u201395 [3] L.A. Falcon Problems associated with the use of arthropod viruses in pest control Ann. Rev. Entomol. 21 1976 305 324 [4] F. Fenner F.N. Ratcliffe Myxomatosis 1965 Cambridge University Press 379p [5] R.M. Anderson R.M. May Regulation and stability of host-parasity population interactions, I. Regulartory processes J. Anim. Ecol. 47 1978 219 247 [6] B.S. Goh The potential utility of control theory to pest management Proc. Ecol. Soc. 6 1971 84 89 [7] P.E. Davis K. Myers J.B. Hoy Biological control among vertebrates C.B. Huffaker P.S. 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D\u2019Onofrio Stability properties of pulse vaccination strategy in SEIR epidemic model Math. Biosci. 179 2002 57 72 [22] B. Shulgin L. Stone Z. Agur Pulse vaccination strategy in the SIR epidemic model Bull. Math. Biol. 60 1998 1 26 [23] M.G. Roberts R.R. Kao The dynamics of an infectious disease in a population with birth pulse Math. Biosci. 149 1998 23 36 [24] Jianjun Jiao Lansun Chen A stage-structured Holling mass defence predator-prey model with impulsive perturbations on predators Appl. Math. Comput. 2007 10.1016/j.amc.2006.12.043",
        "keywords": [
            "chemical control",
            "impulsive",
            "infective",
            "pest-extinction",
            "pest management"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": ""
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, People\u2019s Republic of China"
            },
            {
                "name": "Guilie Luo",
                "org": "School of Mathematical Sciences, Guangxi Normal University, Guilin 541004, People\u2019s Republic of China"
            }
        ],
        "venue": "Applied Mathematics and Computation",
        "year": 2008
    },
    "31X6NH0h": {
        "id": "31X6NH0h",
        "title": "Modeling and analysis of a predator-prey model with disease in the prey.",
        "abstract": "A system of retarded functional differential equations is proposed as a predator-prey model with disease in the prey. Mathematical analyses of the model equations with regard to invariance of non-negativity, boundedness of solutions, nature of equilibria, permanence and global stability are analyzed. If the coefficient in conversing prey into predator k=k(0) is constant (independent of delay tau;, gestation period), we show that positive equilibrium is locally asymptotically stable when time delay tau; is suitable small, while a loss of stability by a Hopf bifurcation can occur as the delay increases. If k=k(0)e(-dtau;) (d is the death rate of predator), numerical simulation suggests that time delay has both destabilizing and stabilizing effects, that is, positive equilibrium, if it exists, will become stable again for large time delay. A concluding discussion is then presented.",
        "keywords": [
            "global stability",
            "permanence",
            "predator\u2013prey model",
            "hopf bifurcation",
            "numerical simulation"
        ],
        "authors": [
            {
                "name": "Y Xiao",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Academia Sinica, Beijing 100080, People's Republic of China"
            },
            {
                "name": "L Chen",
                "org": ""
            }
        ],
        "venue": "Mathematical biosciences",
        "year": 2001
    },
    "Lhg1o2gq": {
        "id": "Lhg1o2gq",
        "title": "Asymptotic behavior of solutions of second-order nonlinear impulsive differential equations",
        "abstract": "In this work, the asymptotic behavior of all solutions of second-order nonlinear ordinary differential equations with impulses is investigated. By impulsive differential inequality and Riccati transformation, sufficient conditions of asymptotic behavior of all solutions of second-order nonlinear ordinary differential equations with impulses are obtained. An example is also inserted to illustrate the impulsive effect.",
        "keywords": [
            "asymptotic",
            "second-order",
            "nonlinear",
            "impulsive differential equation",
            "ordinary differential equation",
            "second order"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, People's Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, People's Republic of China"
            },
            {
                "name": "Limei Li",
                "org": ""
            }
        ],
        "venue": "Journal of Mathematical Analysis and Applications",
        "year": 2008
    },
    "w2N5QMmR": {
        "id": "w2N5QMmR",
        "title": "A single stage-structured population model with mature individuals in a polluted environment and pulse input of environmental toxin",
        "abstract": "In this paper, we concentrates on the study of a single stage-structured population model with mature individuals in a polluted environment and pulse input of environmental toxin. A globally attractive condition for the population-extinction boundary periodic solution of the investigated system is obtained. Sufficient criteria on the permanence of the population are derived.",
        "keywords": [
            "permanence",
            "global arrractivity",
            "stage-structured",
            "single population",
            "population model"
        ],
        "authors": [
            {
                "name": "Jianjun Jiao",
                "org": ""
            },
            {
                "name": "Wen Long",
                "org": "College of Information Science and Engineering, Central South University, Changsha 410083, People\u2019s Republic of China"
            },
            {
                "name": "Lansun Chen",
                "org": "Institute of Mathematics, Academy of Mathematics and System Sciences, Beijing 100080, People\u2019s Republic of China"
            }
        ],
        "venue": "Nonlinear Analysis: Real World Applications",
        "year": 2009
    },
    "KqvOQmZ1": {
        "id": "KqvOQmZ1",
        "title": "STAGE-STRUCTURED MODEL OF A SINGLE-SPECIES WITH DENSITY-DEPENDENT BIRTH PULSES",
        "abstract": "A stage-structured mathematical model of a single-species with density-dependent birth pulses is proposed. We abtain exact periodic solutions of the system with birth pulses and thr